-- dump date 20140620_065236 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 198215000001 SEQ_END SEQ_END NC_004741.1 4599354 4599354 DR NC_004741.1; contig end 4599354..4599354 Shigella flexneri 2a str. 2457T NP_835743.1 CDS thrL NC_004741.1 190 255 D residues 1 to 21 of 21 are 100 pct identical to residues 1 to 21 of 21 from Escherichia coli K-12 : B0001; thr operon leader peptide 190..255 Shigella flexneri 2a str. 2457T 1076421 NP_835744.1 CDS thrA NC_004741.1 336 2798 D multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homeserine dehydrogenase I 336..2798 Shigella flexneri 2a str. 2457T 1076422 NP_835745.1 CDS thrB NC_004741.1 2800 3732 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 2800..3732 Shigella flexneri 2a str. 2457T 1076423 NP_835746.1 CDS thrC NC_004741.1 3733 5019 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 3733..5019 Shigella flexneri 2a str. 2457T 1076424 NP_835747.1 CDS S0005 NC_004741.1 5242 5529 D residues 1 to 65 of 95 are 60.00 pct identical to residues 4 to 68 of 98 from Escherichia coli K-12 : B0005; hypothetical protein 5242..5529 Shigella flexneri 2a str. 2457T 1076425 NP_835748.1 CDS yaaA NC_004741.1 5682 6458 R residues 1 to 258 of 258 are 100.00 pct identical to residues 1 to 258 of 258 from Escherichia coli K-12 : B0006; hypothetical protein complement(5682..6458) Shigella flexneri 2a str. 2457T 1076426 NP_835749.1 CDS talB NC_004741.1 8237 9190 D Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase B 8237..9190 Shigella flexneri 2a str. 2457T 1076428 NP_835750.1 CDS mogA NC_004741.1 9305 9892 D forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein 9305..9892 Shigella flexneri 2a str. 2457T 1076431 NP_835751.1 CDS yaaH NC_004741.1 9927 10493 R residues 1 to 188 of 188 are 92.02 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 : B0010; hypothetical protein complement(9927..10493) Shigella flexneri 2a str. 2457T 1077111 NP_835752.1 CDS S0012 NC_004741.1 10642 11355 R residues 1 to 237 of 237 are 82.27 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B0011; hypothetical protein complement(10642..11355) Shigella flexneri 2a str. 2457T 1078121 NP_835754.1 CDS yaaI NC_004741.1 11381 11785 R residues 1 to 134 of 134 are 99.25 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B0013; hypothetical protein complement(11381..11785) Shigella flexneri 2a str. 2457T 1079962 NP_835755.1 CDS dnaK NC_004741.1 12162 14078 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 12162..14078 Shigella flexneri 2a str. 2457T 1080997 NP_835756.1 CDS dnaJ NC_004741.1 14167 15297 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 14167..15297 Shigella flexneri 2a str. 2457T 1080998 NP_835757.1 CDS gef NC_004741.1 15401 15610 R residues 1 to 69 of 69 are 100.00 pct identical to residues 1 to 69 of 69 from Escherichia coli K-12 : B0018; regulated cell killing; membrane toxin complement(15401..15610) Shigella flexneri 2a str. 2457T 1076443 NP_835758.1 CDS nhaA NC_004741.1 16139 17305 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 16139..17305 Shigella flexneri 2a str. 2457T 1078430 NP_835759.1 CDS nhaR NC_004741.1 17371 18270 D Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 17371..18270 Shigella flexneri 2a str. 2457T 1078188 NP_835760.1 CDS S0020 NC_004741.1 18683 19186 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(18683..19186) Shigella flexneri 2a str. 2457T 1077777 NP_835761.1 CDS S0021 NC_004741.1 19105 19380 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(19105..19380) Shigella flexneri 2a str. 2457T 1077582 NP_835762.2 CDS rpsT NC_004741.1 19769 20032 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(19769..20032) Shigella flexneri 2a str. 2457T 1076778 NP_835763.1 CDS S0023 NC_004741.1 20135 20353 D residues 1 to 72 of 72 are 98.61 pct identical to residues 1 to 72 of 72 from Escherichia coli K-12 : B0024; hypothetical protein 20135..20353 Shigella flexneri 2a str. 2457T 1076482 NP_835764.1 CDS ribF NC_004741.1 20361 21302 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 20361..21302 Shigella flexneri 2a str. 2457T 1076481 NP_835765.1 CDS ileS NC_004741.1 21345 24161 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 21345..24161 Shigella flexneri 2a str. 2457T 1076478 NP_835766.1 CDS lspA NC_004741.1 24161 24655 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 24161..24655 Shigella flexneri 2a str. 2457T 1076476 NP_835767.1 CDS slpA NC_004741.1 24742 25191 D residues 1 to 149 of 149 are 100.00 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B0028; FKBX-type 16kD peptidyl-prolyl cis-trans isomerase (a rotamase) 24742..25191 Shigella flexneri 2a str. 2457T 1076475 NP_835768.1 CDS ispH NC_004741.1 25193 26143 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 25193..26143 Shigella flexneri 2a str. 2457T 1076472 NP_835769.1 CDS yaaF NC_004741.1 26209 27123 D catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 26209..27123 Shigella flexneri 2a str. 2457T 1076471 NP_835770.1 CDS dapB NC_004741.1 27290 28111 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 27290..28111 Shigella flexneri 2a str. 2457T 1076470 NP_835771.1 CDS carA NC_004741.1 28567 29715 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 28567..29715 Shigella flexneri 2a str. 2457T 1076468 NP_835772.1 CDS carB NC_004741.1 29733 32954 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 29733..32954 Shigella flexneri 2a str. 2457T 1076467 NP_835773.2 CDS caiF NC_004741.1 33216 33611 D regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 33216..33611 Shigella flexneri 2a str. 2457T 1076466 NP_835774.1 CDS caiE NC_004741.1 33697 34308 R involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE complement(33697..34308) Shigella flexneri 2a str. 2457T 1076465 NP_835775.1 CDS caiD NC_004741.1 34293 35186 R catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase complement(34293..35186) Shigella flexneri 2a str. 2457T 1076464 NP_835776.1 CDS caiC NC_004741.1 35187 36755 R residues 1 to 522 of 522 are 95.59 pct identical to residues 1 to 522 of 522 from Escherichia coli K-12 : B0037; crotonobetaine/carnitine-CoA ligase complement(35187..36755) Shigella flexneri 2a str. 2457T 1076463 NP_835777.1 CDS caiB NC_004741.1 36814 38031 R catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase complement(36814..38031) Shigella flexneri 2a str. 2457T 1076459 NP_835778.1 CDS caiA NC_004741.1 38160 39302 R catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase complement(38160..39302) Shigella flexneri 2a str. 2457T 1076456 NP_835779.1 CDS caiT NC_004741.1 39333 40847 R catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter complement(39333..40847) Shigella flexneri 2a str. 2457T 1076454 NP_835780.2 CDS fixA NC_004741.1 41203 41973 D required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; electron transfer flavoprotein FixA 41203..41973 Shigella flexneri 2a str. 2457T 1076453 NP_835781.1 CDS fixC NC_004741.1 42980 44266 D FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; oxidoreductase FixC 42980..44266 Shigella flexneri 2a str. 2457T 1076449 NP_835782.1 CDS fixX NC_004741.1 44263 44550 D residues 1 to 95 of 95 are 98.94 pct identical to residues 1 to 95 of 95 from Escherichia coli K-12 : B0044; ferredoxin 44263..44550 Shigella flexneri 2a str. 2457T 1076448 NP_835783.1 CDS yaaU NC_004741.1 44609 46003 D residues 1 to 443 of 464 are 97.06 pct identical to residues 1 to 443 of 443 from Escherichia coli K-12 : B0045; transporter 44609..46003 Shigella flexneri 2a str. 2457T 1076446 NP_835784.1 CDS yabF NC_004741.1 46051 46581 D Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 46051..46581 Shigella flexneri 2a str. 2457T 1076445 NP_835785.1 CDS kefC NC_004741.1 46574 48436 D transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 46574..48436 Shigella flexneri 2a str. 2457T 1076444 NP_835786.1 CDS folA NC_004741.1 48627 49106 D catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 48627..49106 Shigella flexneri 2a str. 2457T 1076432 NP_835787.1 CDS apaH NC_004741.1 49184 50026 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(49184..50026) Shigella flexneri 2a str. 2457T 1076433 NP_835788.1 CDS apaG NC_004741.1 50033 50410 R protein associated with Co2+ and Mg2+ efflux; ApaG protein complement(50033..50410) Shigella flexneri 2a str. 2457T 1076885 NP_835789.1 CDS ksgA NC_004741.1 50413 51234 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(50413..51234) Shigella flexneri 2a str. 2457T 1076435 NP_835790.1 CDS pdxA NC_004741.1 51231 52220 R catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase complement(51231..52220) Shigella flexneri 2a str. 2457T 1078040 NP_835791.1 CDS surA NC_004741.1 52220 53506 R Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA complement(52220..53506) Shigella flexneri 2a str. 2457T 1076439 NP_835792.1 CDS imp NC_004741.1 53559 55913 R determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein complement(53559..55913) Shigella flexneri 2a str. 2457T 1076437 NP_835793.1 CDS djlA NC_004741.1 56168 56983 D functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 56168..56983 Shigella flexneri 2a str. 2457T 1076509 NP_835794.1 CDS yabO NC_004741.1 57100 57759 R catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A complement(57100..57759) Shigella flexneri 2a str. 2457T 1076488 NP_835795.1 CDS hepA NC_004741.1 57771 60677 R transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA complement(57771..60677) Shigella flexneri 2a str. 2457T 1076440 NP_835796.1 CDS polB NC_004741.1 60842 63193 R Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II complement(60842..63193) Shigella flexneri 2a str. 2457T 1076441 NP_835797.1 CDS araD NC_004741.1 63268 63963 R catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase complement(63268..63963) Shigella flexneri 2a str. 2457T 1080994 NP_835798.1 CDS araA NC_004741.1 64163 65665 R catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase complement(64163..65665) Shigella flexneri 2a str. 2457T 1079821 NP_835799.1 CDS araB NC_004741.1 65676 67376 R catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase complement(65676..67376) Shigella flexneri 2a str. 2457T 1079740 NP_835800.1 CDS araC NC_004741.1 67715 68593 D positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 67715..68593 Shigella flexneri 2a str. 2457T 1077806 NP_835801.1 CDS yabI NC_004741.1 68679 69443 D residues 1 to 254 of 254 are 99.21 pct identical to residues 1 to 254 of 254 from Escherichia coli K-12 : B0065; hypothetical protein 68679..69443 Shigella flexneri 2a str. 2457T 1076494 NP_835802.1 CDS thiQ NC_004741.1 69557 70255 R with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit complement(69557..70255) Shigella flexneri 2a str. 2457T 1076495 NP_835803.1 CDS thiP NC_004741.1 70239 71849 R permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein complement(70239..71849) Shigella flexneri 2a str. 2457T 1076814 NP_835804.1 CDS tbpA NC_004741.1 71825 72808 R part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit complement(71825..72808) Shigella flexneri 2a str. 2457T 1076496 NP_835805.1 CDS yabN NC_004741.1 72972 74627 R activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR complement(72972..74627) Shigella flexneri 2a str. 2457T 1080991 NP_835806.1 CDS yabM NC_004741.1 74949 76127 D residues 1 to 392 of 392 are 97.95 pct identical to residues 1 to 392 of 392 from Escherichia coli K-12 : B0070; transporter 74949..76127 Shigella flexneri 2a str. 2457T 1076497 NP_835807.1 CDS leuD NC_004741.1 76176 76781 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(76176..76781) Shigella flexneri 2a str. 2457T 1076498 NP_835808.1 CDS leuC NC_004741.1 76792 78192 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(76792..78192) Shigella flexneri 2a str. 2457T 1076499 NP_835809.2 CDS leuB NC_004741.1 78195 79286 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(78195..79286) Shigella flexneri 2a str. 2457T 1079376 NP_835810.1 CDS leuA NC_004741.1 79286 80857 R catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase complement(79286..80857) Shigella flexneri 2a str. 2457T 1076500 NP_835811.1 CDS leuL NC_004741.1 80950 81036 R involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide complement(80950..81036) Shigella flexneri 2a str. 2457T 1076501 NP_835812.2 CDS leuO NC_004741.1 81695 82639 D activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 81695..82639 Shigella flexneri 2a str. 2457T 1076503 NP_835813.2 CDS ilvI NC_004741.1 82957 84681 D catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 82957..84681 Shigella flexneri 2a str. 2457T 1076504 NP_835814.1 CDS ilvH NC_004741.1 84684 85175 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 84684..85175 Shigella flexneri 2a str. 2457T 1076505 NP_835816.1 CDS fruR NC_004741.1 85356 86360 D binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 85356..86360 Shigella flexneri 2a str. 2457T 1076507 NP_835817.1 CDS S0078 NC_004741.1 86483 86758 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 86483..86758 Shigella flexneri 2a str. 2457T 1076508 NP_835818.1 CDS S0079 NC_004741.1 86677 87180 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 86677..87180 Shigella flexneri 2a str. 2457T 1076510 NP_835819.1 CDS yabB NC_004741.1 87739 88197 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 87739..88197 Shigella flexneri 2a str. 2457T 1076511 NP_835820.1 CDS mraW NC_004741.1 88199 89140 D residues 1 to 313 of 313 are 95.20 pct identical to residues 1 to 313 of 313 from Escherichia coli K-12 : B0082; S-adenosyl-methyltransferase MraW 88199..89140 Shigella flexneri 2a str. 2457T 1078667 NP_835821.1 CDS ftsL NC_004741.1 89137 89502 D membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 89137..89502 Shigella flexneri 2a str. 2457T 1076512 NP_835822.1 CDS ftsI NC_004741.1 89518 91284 D residues 1 to 588 of 588 are 96.76 pct identical to residues 1 to 588 of 588 from Escherichia coli K-12 : B0084; involved in septum formation; penicillin-binding protein 3; peptidoglycan synthetase 89518..91284 Shigella flexneri 2a str. 2457T 1076513 NP_835823.1 CDS murE NC_004741.1 91271 92758 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 91271..92758 Shigella flexneri 2a str. 2457T 1076514 NP_835824.1 CDS murF NC_004741.1 92755 94113 D residues 1 to 452 of 452 are 94.91 pct identical to residues 1 to 452 of 452 from Escherichia coli K-12 : B0086; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 92755..94113 Shigella flexneri 2a str. 2457T 1076515 NP_835825.1 CDS mraY NC_004741.1 94107 95189 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 94107..95189 Shigella flexneri 2a str. 2457T 1076516 NP_835826.1 CDS murD NC_004741.1 95192 96508 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 95192..96508 Shigella flexneri 2a str. 2457T 1076517 NP_835827.1 CDS ftsW NC_004741.1 96508 97752 D integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 96508..97752 Shigella flexneri 2a str. 2457T 1076518 NP_835828.1 CDS murG NC_004741.1 97749 98816 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 97749..98816 Shigella flexneri 2a str. 2457T 1076519 NP_835829.1 CDS murC NC_004741.1 98870 100345 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 98870..100345 Shigella flexneri 2a str. 2457T 1078273 NP_835830.1 CDS ddl NC_004741.1 100338 101258 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 100338..101258 Shigella flexneri 2a str. 2457T 1076520 NP_835831.1 CDS ftsQ NC_004741.1 101260 102090 D involved in septum formation; cell division protein FtsQ 101260..102090 Shigella flexneri 2a str. 2457T 1076521 NP_835832.1 CDS ftsA NC_004741.1 102087 103349 D ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 102087..103349 Shigella flexneri 2a str. 2457T 1076522 NP_835833.1 CDS ftsZ NC_004741.1 103410 104561 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 103410..104561 Shigella flexneri 2a str. 2457T 1076523 NP_835834.1 CDS lpxC NC_004741.1 104662 105579 D zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 104662..105579 Shigella flexneri 2a str. 2457T 1076524 NP_835835.2 CDS yacA NC_004741.1 105810 106322 D secM translational pause allows for the initiation of secA translation; SecA regulator SecM 105810..106322 Shigella flexneri 2a str. 2457T 1076525 NP_835836.1 CDS secA NC_004741.1 106384 109089 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 106384..109089 Shigella flexneri 2a str. 2457T 1076526 NP_835837.1 CDS mutT NC_004741.1 109149 109538 D residues 1 to 129 of 129 are 98.44 pct identical to residues 1 to 129 of 129 from Escherichia coli K-12 : B0099; prefers dGTP, causes AT-GC transversions; nucleoside triphosphate pyrophosphohydrolase 109149..109538 Shigella flexneri 2a str. 2457T 1076527 NP_835838.1 CDS S0099 NC_004741.1 109553 109687 R residues 1 to 44 of 44 are 97.72 pct identical to residues 1 to 44 of 44 from Escherichia coli K-12 : B0100; hypothetical protein complement(109553..109687) Shigella flexneri 2a str. 2457T 1076529 NP_835839.1 CDS yacG NC_004741.1 109638 109835 R residues 1 to 65 of 65 are 100.00 pct identical to residues 1 to 65 of 65 from Escherichia coli K-12 : B0101; zinc-binding protein complement(109638..109835) Shigella flexneri 2a str. 2457T 1076530 NP_835840.1 CDS yacF NC_004741.1 109845 110588 R residues 1 to 247 of 247 are 93.52 pct identical to residues 1 to 247 of 247 from Escherichia coli K-12 : B0102; hypothetical protein complement(109845..110588) Shigella flexneri 2a str. 2457T 1076531 NP_835841.1 CDS coaE NC_004741.1 110588 111208 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(110588..111208) Shigella flexneri 2a str. 2457T 1076532 NP_835842.1 CDS guaC NC_004741.1 111433 112476 D catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 111433..112476 Shigella flexneri 2a str. 2457T 1076533 NP_835843.1 CDS S0104 NC_004741.1 112396 112503 R residues 1 to 35 of 35 are 97.14 pct identical to residues 1 to 35 of 35 from Escherichia coli K-12 : B0105; hypothetical protein complement(112396..112503) Shigella flexneri 2a str. 2457T 1076534 NP_835844.1 CDS hofC NC_004741.1 112511 113713 R residues 1 to 400 of 400 are 85.50 pct identical to residues 1 to 400 of 400 from Escherichia coli K-12 : B0106; involved in biogenesis of fimbriae, protein transport, DNA uptake; type IV pilin biogenesis protein complement(112511..113713) Shigella flexneri 2a str. 2457T 1076537 NP_835845.1 CDS ppdD NC_004741.1 114860 115300 R residues 1 to 146 of 146 are 91.09 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 : B0108; major pilin subunit complement(114860..115300) Shigella flexneri 2a str. 2457T 1076540 NP_835846.1 CDS nadC NC_004741.1 115503 116396 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase complement(115503..116396) Shigella flexneri 2a str. 2457T 1076541 NP_835847.1 CDS ampD NC_004741.1 116484 117035 D residues 1 to 183 of 183 are 97.81 pct identical to residues 1 to 183 of 183 from Escherichia coli K-12 : B0110; regulates ampC; N-acetyl-anhydromuranmyl-L-alanine amidase 116484..117035 Shigella flexneri 2a str. 2457T 1076542 NP_835848.1 CDS ampE NC_004741.1 117032 117886 D involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 117032..117886 Shigella flexneri 2a str. 2457T 1076543 NP_835849.1 CDS aroP NC_004741.1 117929 119302 R residues 1 to 457 of 457 are 93.65 pct identical to residues 1 to 457 of 457 from Escherichia coli K-12 : B0112; aromatic amino acid transporter complement(117929..119302) Shigella flexneri 2a str. 2457T 1076544 NP_835850.1 CDS pdhR NC_004741.1 119843 120607 D activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 119843..120607 Shigella flexneri 2a str. 2457T 1076545 NP_835851.1 CDS aceE NC_004741.1 120768 123431 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 120768..123431 Shigella flexneri 2a str. 2457T 1076546 NP_835852.1 CDS aceF NC_004741.1 123446 125326 D E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 123446..125326 Shigella flexneri 2a str. 2457T 1077898 NP_835853.1 CDS lpdA NC_004741.1 125651 127075 D E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 125651..127075 Shigella flexneri 2a str. 2457T 1076547 NP_835854.1 CDS acnB NC_004741.1 129353 131950 D catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 129353..131950 Shigella flexneri 2a str. 2457T 1079612 NP_835855.2 CDS yacL NC_004741.1 132125 132487 D residues 1 to 136 of 136 are 98.52 pct identical to residues 1 to 136 of 136 from Escherichia coli K-12 : B0119; hypothetical protein 132125..132487 Shigella flexneri 2a str. 2457T 1076549 NP_835856.1 CDS speD NC_004741.1 132525 133319 R S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase complement(132525..133319) Shigella flexneri 2a str. 2457T 1080931 NP_835857.1 CDS speE NC_004741.1 133335 134201 R catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase complement(133335..134201) Shigella flexneri 2a str. 2457T 1076550 NP_835858.1 CDS yacC NC_004741.1 134307 134777 R residues 1 to 156 of 156 are 98.71 pct identical to residues 1 to 156 of 156 from Escherichia coli K-12 : B0122; hypothetical protein complement(134307..134777) Shigella flexneri 2a str. 2457T 1076551 NP_835859.1 CDS yacK NC_004741.1 134820 136370 D laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 134820..136370 Shigella flexneri 2a str. 2457T 1076552 NP_835860.1 CDS gcd NC_004741.1 136417 138807 R residues 1 to 796 of 796 are 93.09 pct identical to residues 1 to 796 of 796 from Escherichia coli K-12 : B0124; glucose dehydrogenase complement(136417..138807) Shigella flexneri 2a str. 2457T 1076554 NP_835861.2 CDS hpt NC_004741.1 139013 139549 D Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 139013..139549 Shigella flexneri 2a str. 2457T 1076555 NP_835862.1 CDS yadF NC_004741.1 139590 140252 R catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase complement(139590..140252) Shigella flexneri 2a str. 2457T 1076556 NP_835863.1 CDS yadG NC_004741.1 140361 141287 D residues 1 to 308 of 308 are 99.67 pct identical to residues 1 to 308 of 308 from Escherichia coli K-12 : B0127; ATP-binding component of a transport system 140361..141287 Shigella flexneri 2a str. 2457T 1076558 NP_835864.1 CDS yadH NC_004741.1 141284 142054 D residues 1 to 256 of 256 are 89.06 pct identical to residues 1 to 256 of 256 from Escherichia coli K-12 : B0128; hypothetical protein 141284..142054 Shigella flexneri 2a str. 2457T 1076559 NP_835865.1 CDS yadI NC_004741.1 142159 142599 D residues 1 to 146 of 146 are 98.63 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 : B0129; PTS enzyme II B component 142159..142599 Shigella flexneri 2a str. 2457T 1076560 NP_835866.1 CDS yadE NC_004741.1 142663 143892 D residues 1 to 409 of 409 are 97.79 pct identical to residues 1 to 409 of 409 from Escherichia coli K-12 : B0130; hypothetical protein 142663..143892 Shigella flexneri 2a str. 2457T 1076561 NP_835867.1 CDS panD NC_004741.1 143896 144276 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(143896..144276) Shigella flexneri 2a str. 2457T 1076562 NP_835868.1 CDS yadD NC_004741.1 144550 145452 D residues 1 to 300 of 300 are 92.66 pct identical to residues 1 to 300 of 300 from Escherichia coli K-12 : B0132; hypothetical protein 144550..145452 Shigella flexneri 2a str. 2457T 1077863 NP_835869.1 CDS panC NC_004741.1 145526 146377 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(145526..146377) Shigella flexneri 2a str. 2457T 1076563 NP_835870.1 CDS panB NC_004741.1 146389 147183 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(146389..147183) Shigella flexneri 2a str. 2457T 1076564 NP_835871.1 CDS S0134 NC_004741.1 147677 147952 D residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 147677..147952 Shigella flexneri 2a str. 2457T 1076567 NP_835872.1 CDS S0136 NC_004741.1 147871 148374 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 147871..148374 Shigella flexneri 2a str. 2457T 1076568 NP_835873.1 CDS folK NC_004741.1 148522 149001 R catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase complement(148522..149001) Shigella flexneri 2a str. 2457T 1076569 NP_835874.2 CDS pcnB NC_004741.1 148998 150416 R Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase I complement(148998..150416) Shigella flexneri 2a str. 2457T 1076570 NP_835875.2 CDS yadB NC_004741.1 150455 151351 R this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase complement(150455..151351) Shigella flexneri 2a str. 2457T 1076573 NP_835876.1 CDS dksA NC_004741.1 151418 151873 R residues 1 to 151 of 151 are 90.06 pct identical to residues 1 to 151 of 151 from Escherichia coli K-12 : B0145; DnaK transcriptional regulator DksA complement(151418..151873) Shigella flexneri 2a str. 2457T 1076574 NP_835877.1 CDS sfsA NC_004741.1 152051 152755 R Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A complement(152051..152755) Shigella flexneri 2a str. 2457T 1076575 NP_835878.1 CDS yadP NC_004741.1 152770 153309 R residues 1 to 179 of 179 are 99.44 pct identical to residues 1 to 179 of 179 from Escherichia coli K-12 : B0147; hypothetical protein complement(152770..153309) Shigella flexneri 2a str. 2457T 1076576 NP_835879.1 CDS hrpB NC_004741.1 153329 155803 D similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 153329..155803 Shigella flexneri 2a str. 2457T 1076578 NP_835880.1 CDS mrcB NC_004741.1 155999 158533 D bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 155999..158533 Shigella flexneri 2a str. 2457T 1076579 NP_835881.1 CDS fhuA NC_004741.1 158753 160996 D involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 158753..160996 Shigella flexneri 2a str. 2457T 1076580 NP_835882.1 CDS fhuC NC_004741.1 161047 161844 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 161047..161844 Shigella flexneri 2a str. 2457T 1076581 NP_835883.1 CDS fhuD NC_004741.1 161844 162734 D Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 161844..162734 Shigella flexneri 2a str. 2457T 1076582 NP_835884.1 CDS fhuB NC_004741.1 162731 164713 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 162731..164713 Shigella flexneri 2a str. 2457T 1076583 NP_835885.1 CDS hemL NC_004741.1 164748 166028 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(164748..166028) Shigella flexneri 2a str. 2457T 1076566 NP_835886.1 CDS yadQ NC_004741.1 166253 167674 D Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 166253..167674 Shigella flexneri 2a str. 2457T 1076584 NP_835887.1 CDS yadR NC_004741.1 167756 168100 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 167756..168100 Shigella flexneri 2a str. 2457T 1077758 NP_835888.1 CDS yadS NC_004741.1 168147 168770 R residues 1 to 207 of 207 are 85.99 pct identical to residues 1 to 207 of 207 from Escherichia coli K-12 : B0157; hypothetical protein complement(168147..168770) Shigella flexneri 2a str. 2457T 1076585 NP_835889.1 CDS yadT NC_004741.1 168808 169608 R solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF complement(168808..169608) Shigella flexneri 2a str. 2457T 1076586 NP_835890.1 CDS pfs NC_004741.1 169601 170299 R enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(169601..170299) Shigella flexneri 2a str. 2457T 1076587 NP_835891.1 CDS dgt NC_004741.1 170383 171900 D forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 170383..171900 Shigella flexneri 2a str. 2457T 1076588 NP_835892.1 CDS htrA NC_004741.1 172030 173454 D protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 172030..173454 Shigella flexneri 2a str. 2457T 1076589 NP_835893.1 CDS yaeH NC_004741.1 174854 175240 R residues 1 to 128 of 128 are 100.00 pct identical to residues 1 to 128 of 128 from Escherichia coli K-12 : B0163; hypothetical protein complement(174854..175240) Shigella flexneri 2a str. 2457T 1076591 NP_835894.1 CDS dapD NC_004741.1 175554 176378 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(175554..176378) Shigella flexneri 2a str. 2457T 1076592 NP_835895.1 CDS glnD NC_004741.1 176409 179081 R catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase complement(176409..179081) Shigella flexneri 2a str. 2457T 1076593 NP_835896.1 CDS map NC_004741.1 179143 179937 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(179143..179937) Shigella flexneri 2a str. 2457T 1076594 NP_835897.1 CDS rpsB NC_004741.1 180305 181030 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 180305..181030 Shigella flexneri 2a str. 2457T 1079387 NP_835898.1 CDS tsf NC_004741.1 181288 182139 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 181288..182139 Shigella flexneri 2a str. 2457T 1076595 NP_835899.1 CDS pyrH NC_004741.1 182286 183011 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 182286..183011 Shigella flexneri 2a str. 2457T 1076596 NP_835900.1 CDS frr NC_004741.1 183303 183860 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 183303..183860 Shigella flexneri 2a str. 2457T 1076597 NP_835901.1 CDS yaeM NC_004741.1 183952 185148 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 183952..185148 Shigella flexneri 2a str. 2457T 1076598 NP_835902.1 CDS yaeS NC_004741.1 185334 186095 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 185334..186095 Shigella flexneri 2a str. 2457T 1076661 NP_835903.2 CDS cdsA NC_004741.1 186108 186965 D catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 186108..186965 Shigella flexneri 2a str. 2457T 1076599 NP_835904.1 CDS yaeL NC_004741.1 186977 188329 D catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 186977..188329 Shigella flexneri 2a str. 2457T 1079703 NP_835905.1 CDS yaeT NC_004741.1 188359 190791 D part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 188359..190791 Shigella flexneri 2a str. 2457T 1080985 NP_835906.1 CDS hlpA NC_004741.1 190913 191398 D residues 1 to 161 of 161 are 89.44 pct identical to residues 1 to 161 of 161 from Escherichia coli K-12 : B0178; located in outer membrane or nucleoid; periplasmic chaperone 190913..191398 Shigella flexneri 2a str. 2457T 1076600 NP_835907.1 CDS lpxD NC_004741.1 191402 192427 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 191402..192427 Shigella flexneri 2a str. 2457T 1076601 NP_835908.1 CDS fabZ NC_004741.1 192532 192987 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 192532..192987 Shigella flexneri 2a str. 2457T 1080987 NP_835909.1 CDS lpxA NC_004741.1 192991 193779 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 192991..193779 Shigella flexneri 2a str. 2457T 1080989 NP_835910.1 CDS lpxB NC_004741.1 193779 194927 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 193779..194927 Shigella flexneri 2a str. 2457T 1076602 NP_835911.1 CDS rnhB NC_004741.1 194924 195520 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 194924..195520 Shigella flexneri 2a str. 2457T 1076604 NP_835912.1 CDS dnaE NC_004741.1 195557 199039 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 195557..199039 Shigella flexneri 2a str. 2457T 1076605 NP_835913.1 CDS accA NC_004741.1 199052 200011 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 199052..200011 Shigella flexneri 2a str. 2457T 1076606 NP_835914.1 CDS ldcC NC_004741.1 200110 202251 D residues 1 to 713 of 713 are 99.15 pct identical to residues 1 to 713 of 713 from Escherichia coli K-12 : B0186; lysine decarboxylase 2 200110..202251 Shigella flexneri 2a str. 2457T 1076607 NP_835915.2 CDS yaeR NC_004741.1 202308 202697 D residues 1 to 138 of 138 are 89.13 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 : B0187; hypothetical protein 202308..202697 Shigella flexneri 2a str. 2457T 1079983 NP_835916.1 CDS tilS NC_004741.1 202762 204060 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 202762..204060 Shigella flexneri 2a str. 2457T 1076608 NP_835917.1 CDS yaeO NC_004741.1 204109 204369 R Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator complement(204109..204369) Shigella flexneri 2a str. 2457T 1076609 NP_835918.1 CDS yaeQ NC_004741.1 204722 205267 D residues 1 to 181 of 181 are 100.00 pct identical to residues 1 to 181 of 181 from Escherichia coli K-12 : B0190; hypothetical protein 204722..205267 Shigella flexneri 2a str. 2457T 1076610 NP_835919.1 CDS yaeJ NC_004741.1 205264 205686 D residues 1 to 140 of 140 are 97.14 pct identical to residues 1 to 140 of 140 from Escherichia coli K-12 : B0191; peptidyl-tRNA hydrolase domain protein 205264..205686 Shigella flexneri 2a str. 2457T 1076611 NP_835920.1 CDS cutF NC_004741.1 205700 206410 D residues 1 to 236 of 236 are 98.30 pct identical to residues 1 to 236 of 236 from Escherichia coli K-12 : B0192; lipoprotein involved with copper homeostasis and adhesion 205700..206410 Shigella flexneri 2a str. 2457T 1076612 NP_835921.1 CDS yaeF NC_004741.1 206565 207389 R residues 1 to 274 of 274 are 94.89 pct identical to residues 19 to 292 of 292 from Escherichia coli K-12 : B0193; hypothetical protein complement(206565..207389) Shigella flexneri 2a str. 2457T 1076613 NP_835922.1 CDS proS NC_004741.1 207442 209160 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(207442..209160) Shigella flexneri 2a str. 2457T 1076614 NP_835923.1 CDS yaeB NC_004741.1 209271 209978 R residues 1 to 235 of 235 are 92.76 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B0195; hypothetical protein complement(209271..209978) Shigella flexneri 2a str. 2457T 1076615 NP_835924.1 CDS rcsF NC_004741.1 209975 210379 R residues 1 to 134 of 134 are 85.82 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B0196; involved in colanic acid synthesis; interacts with RcsB; outer membrane lipoprotein complement(209975..210379) Shigella flexneri 2a str. 2457T 1076617 NP_835925.1 CDS metQ NC_004741.1 210497 211312 R residues 1 to 271 of 271 are 94.83 pct identical to residues 1 to 271 of 271 from Escherichia coli K-12 : B0197; DL-methionine transporter substrate-binding subunit complement(210497..211312) Shigella flexneri 2a str. 2457T 1076620 NP_835926.1 CDS yaeE NC_004741.1 211352 212005 R part of the MetNIQ methionine uptake system; DL-methionine transporter permease subunit complement(211352..212005) Shigella flexneri 2a str. 2457T 1076622 NP_835927.1 CDS metN NC_004741.1 211998 213029 R part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit complement(211998..213029) Shigella flexneri 2a str. 2457T 1077808 NP_835928.1 CDS yaeD NC_004741.1 213217 213792 D Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 213217..213792 Shigella flexneri 2a str. 2457T 1076623 NP_835929.1 CDS dkgB NC_004741.1 219551 220354 D catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 219551..220354 Shigella flexneri 2a str. 2457T 1076632 NP_835930.1 CDS S0201 NC_004741.1 220393 221721 R residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf complement(220393..221721) Shigella flexneri 2a str. 2457T 1078798 NP_835931.1 CDS yafC NC_004741.1 221789 222703 R residues 1 to 301 of 304 are 98.67 pct identical to residues 1 to 301 of 304 from Escherichia coli K-12 : B0208; transcriptional regulator LYSR-type complement(221789..222703) Shigella flexneri 2a str. 2457T 1076633 NP_835932.1 CDS yafD NC_004741.1 222944 223744 D residues 1 to 266 of 266 are 100.00 pct identical to residues 1 to 266 of 266 from Escherichia coli K-12 : B0209; hypothetical protein 222944..223744 Shigella flexneri 2a str. 2457T 1076636 NP_835933.1 CDS yafE NC_004741.1 223972 224592 D residues 2 to 206 of 206 are 93.65 pct identical to residues 3 to 207 of 207 from Escherichia coli K-12 : B0210; biotin synthesis protein 223972..224592 Shigella flexneri 2a str. 2457T 1078831 NP_835934.1 CDS mltD NC_004741.1 224640 225986 R catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D complement(224640..225986) Shigella flexneri 2a str. 2457T 1076635 NP_835935.1 CDS gloB NC_004741.1 226058 226813 R catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase complement(226058..226813) Shigella flexneri 2a str. 2457T 1076639 NP_835936.1 CDS yafS NC_004741.1 226844 227569 D residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B0213; hypothetical protein 226844..227569 Shigella flexneri 2a str. 2457T 1076640 NP_835937.1 CDS rnhA NC_004741.1 227566 228033 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H complement(227566..228033) Shigella flexneri 2a str. 2457T 1078814 NP_835938.1 CDS dnaQ NC_004741.1 228098 228829 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 228098..228829 Shigella flexneri 2a str. 2457T 1076650 NP_835939.1 CDS safA NC_004741.1 229169 230215 R residues 1 to 348 of 348 are 68.66 pct identical to residues 1 to 351 of 351 from GenPept : >gb|AAL19222.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein complement(229169..230215) Shigella flexneri 2a str. 2457T 1078803 NP_835940.1 CDS S0212 NC_004741.1 230226 230339 R residues 1 to 37 of 37 are 86.48 pct identical to residues 154 to 190 of 331 from GenPept : >gb|AAL19223.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein complement(230226..230339) Shigella flexneri 2a str. 2457T 1080072 NP_835941.1 CDS safB NC_004741.1 230483 230788 R residues 1 to 100 of 101 are 79.00 pct identical to residues 1 to 100 of 331 from GenPept : >gb|AAL19223.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; periplasmic chaperone of fimbral assembly machinery complement(230483..230788) Shigella flexneri 2a str. 2457T 1076643 NP_835942.1 CDS safC NC_004741.1 230785 232668 R residues 1 to 627 of 627 are 91.54 pct identical to residues 1 to 627 of 627 from GenPept : >gb|AAL19224.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; outer membrane usher protein complement(230785..232668) Shigella flexneri 2a str. 2457T 1076644 NP_835943.1 CDS S0215 NC_004741.1 232684 233178 R residues 1 to 164 of 164 are 78.65 pct identical to residues 1 to 164 of 164 from GenPept : >emb|CAD08723.1| (AL627266) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(232684..233178) Shigella flexneri 2a str. 2457T 1076651 NP_835944.1 CDS sat1 NC_004741.1 233373 234005 R residues 1 to 210 of 210 are 69.99 pct identical to residues 1 to 208 of 274 from GenPept : >gb|AAL19226.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein complement(233373..234005) Shigella flexneri 2a str. 2457T 1076652 NP_835945.1 CDS sat2 NC_004741.1 233992 234369 R residues 6 to 124 of 125 are 56.66 pct identical to residues 180 to 299 of 300 from GenPept : >gb|AAL19227.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein complement(233992..234369) Shigella flexneri 2a str. 2457T 1078828 NP_835946.1 CDS S0219 NC_004741.1 234607 234906 R residues 7 to 99 of 99 are 61.29 pct identical to residues 6 to 97 of 300 from GenPept : >gb|AAL19227.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein complement(234607..234906) Shigella flexneri 2a str. 2457T 1076634 NP_835947.1 CDS S0220 NC_004741.1 234959 235369 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 234959..235369 Shigella flexneri 2a str. 2457T 1076654 NP_835948.1 CDS S0221 NC_004741.1 235327 236232 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 235327..236232 Shigella flexneri 2a str. 2457T 1076656 NP_835949.1 CDS S0223 NC_004741.1 236654 236956 D residues 1 to 100 of 100 are 99.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 236654..236956 Shigella flexneri 2a str. 2457T 1076657 NP_835950.1 CDS S0224 NC_004741.1 236983 237822 D residues 19 to 297 of 297 are 99.28 pct identical to residues 1 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; IS911 orfB 236983..237822 Shigella flexneri 2a str. 2457T 1076660 NP_835952.1 CDS S0229 NC_004741.1 238511 238780 R residues 1 to 89 of 89 are 96.62 pct identical to residues 89 to 177 of 177 from GenPept : >gb|AAC74627.1| (AE000252) lysozyme [Escherichia coli K12]; endolysin R of prophage CP-933V complement(238511..238780) Shigella flexneri 2a str. 2457T 1076663 NP_835953.1 CDS S0230 NC_004741.1 239101 239415 R residues 1 to 99 of 104 are 64.64 pct identical to residues 1 to 93 of 103 from GenPept : >gb|AAC74628.1| (AE000252) orf, hypothetical protein [Escherichia coli K12]; hypothetical protein complement(239101..239415) Shigella flexneri 2a str. 2457T 1078781 NP_835954.1 CDS S0231 NC_004741.1 239420 239635 R residues 1 to 71 of 71 are 97.18 pct identical to residues 1 to 71 of 71 from GenPept : >gb|AAA32349.1| (M65239) S [Bacteriophage 21]; lysis protein S complement(239420..239635) Shigella flexneri 2a str. 2457T 1078780 NP_835955.1 CDS S0232 NC_004741.1 239992 240366 D no significant similarities; hypothetical protein 239992..240366 Shigella flexneri 2a str. 2457T 1076666 NP_835956.1 CDS S0233 NC_004741.1 240390 240797 R residues 7 to 126 of 135 are 29.83 pct identical to residues 203 to 324 of 327 from GenPept : >emb|CAD02863.1| (AL627277) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(240390..240797) Shigella flexneri 2a str. 2457T 1076668 NP_835957.1 CDS S0235 NC_004741.1 240794 241846 R residues 72 to 350 of 350 are 99.64 pct identical to residues 1 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; IS911 orfA complement(240794..241846) Shigella flexneri 2a str. 2457T 1076665 NP_835958.1 CDS S0234 NC_004741.1 240794 241633 R residues 19 to 297 of 297 are 99.64 pct identical to residues 1 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; IS911 orfB complement(240794..241633) Shigella flexneri 2a str. 2457T 1076669 NP_835959.1 CDS S0236 NC_004741.1 242170 242730 D residues 1 to 184 of 186 are 89.67 pct identical to residues 200 to 383 of 499 from GenPept : >gb|AAF75044.1| (AF217253) terminase large subunit [Enterobacteria phage P22]; terminase large subunit 242170..242730 Shigella flexneri 2a str. 2457T 1078818 NP_835960.1 CDS S0237 NC_004741.1 242699 243073 D residues 7 to 99 of 124 are 82.79 pct identical to residues 382 to 474 of 499 from GenPept : >gb|AAF75044.1| (AF217253) terminase large subunit [Enterobacteria phage P22]; terminase large subunit 242699..243073 Shigella flexneri 2a str. 2457T 1076681 NP_835961.1 CDS S0238 NC_004741.1 243074 245239 D residues 1 to 721 of 721 are 72.48 pct identical to residues 1 to 725 of 725 from GenPept : >gb|AAF75045.1| (AF217253) portal protein [Enterobacteria phage P22]; packaging glycoprotein 243074..245239 Shigella flexneri 2a str. 2457T 1076671 NP_835962.1 CDS S0239 NC_004741.1 245253 246164 D residues 1 to 303 of 303 are 79.27 pct identical to residues 1 to 303 of 303 from GenPept : >gb|AAF75046.1| (AF217253) scaffolding protein [Enterobacteria phage P22]; scaffolding protein 245253..246164 Shigella flexneri 2a str. 2457T 1076672 NP_835963.1 CDS S0240 NC_004741.1 246164 247459 D residues 1 to 431 of 431 are 72.62 pct identical to residues 1 to 430 of 430 from GenPept : >gb|AAF75047.1| (AF217253) coat protein [Enterobacteria phage P22]; coat protein 246164..247459 Shigella flexneri 2a str. 2457T 1076673 NP_835964.1 CDS S0241 NC_004741.1 247504 247734 D no significant similarities; hypothetical protein 247504..247734 Shigella flexneri 2a str. 2457T 1078862 NP_835965.1 CDS S0242 NC_004741.1 247712 248212 D residues 1 to 163 of 166 are 60.12 pct identical to residues 1 to 157 of 166 from GenPept : >gb|AAF75049.1| (AF217253) DNA stabilization protein [Enterobacteria phage P22]; DNA stabilization protein 247712..248212 Shigella flexneri 2a str. 2457T 1076695 NP_835966.1 CDS S0243 NC_004741.1 248212 249630 D residues 1 to 472 of 472 are 98.72 pct identical to residues 1 to 472 of 472 from GenPept : >gb|AAK28897.1|AF335538_49 (AF335538) DNA stabilization protein [Bacteriophage HK620]; packaged DNA stabilization protein 248212..249630 Shigella flexneri 2a str. 2457T 1076674 NP_835967.1 CDS S0244 NC_004741.1 249630 250478 D residues 96 to 282 of 282 are 87.16 pct identical to residues 3 to 189 of 189 from GenPept : >gb|AAG57480.1|AE005466_10 (AE005466) Z3617 gene product [Escherichia coli O157:H7 EDL933]; packaged DNA stabilization protein 249630..250478 Shigella flexneri 2a str. 2457T 1080087 NP_835968.1 CDS S0245 NC_004741.1 250478 250933 D residues 1 to 151 of 151 are 98.67 pct identical to residues 1 to 151 of 151 from GenPept : >gb|AAK28899.1|AF335538_51 (AF335538) head assembly protein [Bacteriophage HK620]; head assembly protein 250478..250933 Shigella flexneri 2a str. 2457T 1078779 NP_835969.1 CDS S0246 NC_004741.1 250936 251628 D residues 1 to 230 of 230 are 52.60 pct identical to residues 1 to 230 of 230 from GenPept : >gb|AAK28900.1|AF335538_52 (AF335538) DNA transfer protein [Bacteriophage HK620]; DNA transfer protein 250936..251628 Shigella flexneri 2a str. 2457T 1076675 NP_835970.1 CDS S0247 NC_004741.1 251638 252969 D residues 1 to 216 of 443 are 57.79 pct identical to residues 1 to 215 of 378 from GenPept : >gb|AAG57477.1|AE005466_7 (AE005466) prophage DNA injection protein [Escherichia coli O157:H7 EDL933]; prophage DNA injection protein 251638..252969 Shigella flexneri 2a str. 2457T 1076677 NP_835971.1 CDS S0248 NC_004741.1 252970 254700 D residues 217 to 348 of 576 are 76.35 pct identical to residues 60 to 207 of 722 from GenPept : >gb|AAK28902.1|AF335538_54 (AF335538) DNA transfer protein [Bacteriophage HK620]; DNA transfer protein 252970..254700 Shigella flexneri 2a str. 2457T 1076678 NP_835972.1 CDS S0249 NC_004741.1 254826 255152 D residues 1 to 108 of 108 are 74.07 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72412.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA 254826..255152 Shigella flexneri 2a str. 2457T 1076679 NP_835973.1 CDS S0250 NC_004741.1 255387 256034 D residues 1 to 215 of 215 are 98.13 pct identical to residues 8 to 222 of 222 from GenPept : >gb|AAL72361.1| (AF386526) transposase [Shigella flexneri 2a]; IS629 orfB 255387..256034 Shigella flexneri 2a str. 2457T 1076680 NP_835974.1 CDS psiF NC_004741.1 256085 256423 R residues 1 to 112 of 112 are 83.92 pct identical to residues 1 to 112 of 112 from Escherichia coli K-12 : B0384; hypothetical protein complement(256085..256423) Shigella flexneri 2a str. 2457T 1076683 NP_835975.1 CDS phoA NC_004741.1 256524 258008 R residues 1 to 487 of 487 are 96.71 pct identical to residues 8 to 494 of 494 from Escherichia coli K-12 : B0383; alkaline phosphatase complement(256524..258008) Shigella flexneri 2a str. 2457T 1076684 NP_835976.1 CDS yaiB NC_004741.1 258040 258300 R residues 1 to 86 of 86 are 98.83 pct identical to residues 1 to 86 of 86 from Escherichia coli K-12 : B0382; hypothetical protein complement(258040..258300) Shigella flexneri 2a str. 2457T 1076685 NP_835977.1 CDS ddl NC_004741.1 258763 259857 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 258763..259857 Shigella flexneri 2a str. 2457T 1076687 NP_835978.1 CDS S0255 NC_004741.1 259881 260225 R residues 1 to 114 of 114 are 97.36 pct identical to residues 1 to 114 of 114 from Escherichia coli K-12 : B0380; hypothetical protein complement(259881..260225) Shigella flexneri 2a str. 2457T 1076688 NP_835979.1 CDS S0256 NC_004741.1 260353 260661 D residues 1 to 102 of 102 are 99.01 pct identical to residues 1 to 102 of 102 from Escherichia coli K-12 : B0379; hypothetical protein 260353..260661 Shigella flexneri 2a str. 2457T 1076689 NP_835980.1 CDS yaiW NC_004741.1 260720 261814 R residues 1 to 364 of 364 are 95.05 pct identical to residues 1 to 364 of 364 from Escherichia coli K-12 : B0378; hypothetical protein complement(260720..261814) Shigella flexneri 2a str. 2457T 1076690 NP_835981.1 CDS sbmA NC_004741.1 261827 263047 R in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transporter complement(261827..263047) Shigella flexneri 2a str. 2457T 1076691 NP_835982.1 CDS yaiH NC_004741.1 263399 264556 D this protein has no known enzymatic function; beta-lactam binding protein AmpH 263399..264556 Shigella flexneri 2a str. 2457T 1076692 NP_835983.1 CDS S0262 NC_004741.1 265695 266507 R residues 1 to 270 of 270 are 95.92 pct identical to residues 10 to 279 of 279 from GenPept : >gb|AAG53988.1|AF327445_2 (AF327445) transposase B [Pantoea agglomerans]; ISEhe3 orfB complement(265695..266507) Shigella flexneri 2a str. 2457T 1076696 NP_835984.1 CDS S0263 NC_004741.1 266781 267494 R residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB complement(266781..267494) Shigella flexneri 2a str. 2457T 1077596 NP_835985.1 CDS is600a NC_004741.1 267635 267937 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA complement(267635..267937) Shigella flexneri 2a str. 2457T 1077611 NP_835986.2 CDS yi22_6 NC_004741.1 268714 269619 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(268714..269619) Shigella flexneri 2a str. 2457T 1077812 NP_835987.2 CDS yi21_6 NC_004741.1 269577 269942 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(269577..269942) Shigella flexneri 2a str. 2457T 1076699 NP_835988.1 CDS S0269 NC_004741.1 270487 270756 D residues 1 to 89 of 89 are 80.89 pct identical to residues 1 to 89 of 89 from Escherichia coli K-12 : B0370; hypothetical protein 270487..270756 Shigella flexneri 2a str. 2457T 1076700 NP_835989.1 CDS hemB NC_004741.1 270893 271900 D catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 270893..271900 Shigella flexneri 2a str. 2457T 1076701 NP_835990.1 CDS tauD NC_004741.1 272006 272857 R catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase complement(272006..272857) Shigella flexneri 2a str. 2457T 1076702 NP_835991.1 CDS tauC NC_004741.1 272854 273681 R residues 1 to 275 of 275 are 90.54 pct identical to residues 1 to 275 of 275 from Escherichia coli K-12 : B0367; taurine transporter subunit complement(272854..273681) Shigella flexneri 2a str. 2457T 1077158 NP_835992.1 CDS tauB NC_004741.1 273678 274445 R Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit complement(273678..274445) Shigella flexneri 2a str. 2457T 1076703 NP_835993.1 CDS tauA NC_004741.1 274458 275354 R with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit complement(274458..275354) Shigella flexneri 2a str. 2457T 1076704 NP_835994.1 CDS S0275 NC_004741.1 275912 276415 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(275912..276415) Shigella flexneri 2a str. 2457T 1076705 NP_835995.1 CDS S0276 NC_004741.1 276334 276609 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(276334..276609) Shigella flexneri 2a str. 2457T 1076706 NP_835996.1 CDS ykgH NC_004741.1 276754 277422 D residues 1 to 222 of 222 are 97.29 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 : B0310; hypothetical protein 276754..277422 Shigella flexneri 2a str. 2457T 1076707 NP_835997.1 CDS S0278 NC_004741.1 277498 277710 D residues 1 to 70 of 70 are 72.85 pct identical to residues 1 to 70 of 70 from Escherichia coli K-12 : B0309; hypothetical protein 277498..277710 Shigella flexneri 2a str. 2457T 1076709 NP_835998.2 CDS ykgG NC_004741.1 277665 278360 R residues 1 to 280 of 280 are 94.64 pct identical to residues 3 to 282 of 282 from Escherichia coli K-12 : B0308; transporter complement(277665..278360) Shigella flexneri 2a str. 2457T 1076710 NP_835999.1 CDS ykgF NC_004741.1 278353 279780 R residues 1 to 475 of 475 are 99.36 pct identical to residues 1 to 475 of 475 from Escherichia coli K-12 : B0307; hypothetical protein complement(278353..279780) Shigella flexneri 2a str. 2457T 1076711 NP_836000.1 CDS ykgE NC_004741.1 279791 280510 R residues 1 to 239 of 239 are 98.74 pct identical to residues 1 to 239 of 239 from Escherichia coli K-12 : B0306; dehydrogenase subunit complement(279791..280510) Shigella flexneri 2a str. 2457T 1076712 NP_836001.1 CDS S0282 NC_004741.1 280929 281204 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 280929..281204 Shigella flexneri 2a str. 2457T 1076697 NP_836002.1 CDS S0283 NC_004741.1 281123 281626 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 281123..281626 Shigella flexneri 2a str. 2457T 1076713 NP_836003.1 CDS rhsG NC_004741.1 282704 284917 D residues 1 to 734 of 737 are 80.92 pct identical to residues 1 to 729 of 729 from GenPept : >emb|CAD08749.1| (AL627266) Rhs-family protein [Salmonella enterica subsp. enterica serovar Typhi]; Rhs-family protein 282704..284917 Shigella flexneri 2a str. 2457T 1076714 NP_836004.1 CDS S0285 NC_004741.1 284940 285140 D residues 5 to 64 of 66 are 78.33 pct identical to residues 5 to 64 of 148 from GenPept : >gb|AAL19247.1| (AE008708) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein 284940..285140 Shigella flexneri 2a str. 2457T 1076715 NP_836005.1 CDS S0286 NC_004741.1 285197 285385 D residues 1 to 62 of 62 are 67.74 pct identical to residues 86 to 147 of 148 from GenPept : >gb|AAL19247.1| (AE008708) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein 285197..285385 Shigella flexneri 2a str. 2457T 1076716 NP_836006.1 CDS S0287 NC_004741.1 285407 285814 D residues 1 to 127 of 135 are 68.50 pct identical to residues 1 to 127 of 1354 from GenPept : >emb|CAD08751.1| (AL627266) Rhs-family protein [Salmonella enterica subsp. enterica serovar Typhi]; Rhs-family protein 285407..285814 Shigella flexneri 2a str. 2457T 1076717 NP_836007.1 CDS rhsD NC_004741.1 285811 288099 D residues 1 to 759 of 762 are 69.22 pct identical to residues 137 to 954 of 1364 from GenPept : >gb|AAL19248.1| (AE008708) RHS-family protein [Salmonella typhimurium LT2]; Rhs-family protein 285811..288099 Shigella flexneri 2a str. 2457T 1076718 NP_836008.1 CDS rhs-like NC_004741.1 288096 289085 D residues 1 to 291 of 329 are 78.76 pct identical to residues 961 to 1252 of 1354 from GenPept : >emb|CAD08751.1| (AL627266) Rhs-family protein [Salmonella enterica subsp. enterica serovar Typhi]; Rhs-family protein 288096..289085 Shigella flexneri 2a str. 2457T 1076719 NP_836009.1 CDS yafV NC_004741.1 290134 290904 R residues 1 to 256 of 256 are 98.04 pct identical to residues 1 to 256 of 256 from Escherichia coli K-12 : B0219; hypothetical protein complement(290134..290904) Shigella flexneri 2a str. 2457T 1076720 NP_836010.1 CDS ykfE NC_004741.1 291058 291531 D inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 291058..291531 Shigella flexneri 2a str. 2457T 1076721 NP_836011.2 CDS fadE NC_004741.1 291574 294018 R functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase complement(291574..294018) Shigella flexneri 2a str. 2457T 1076722 NP_836012.1 CDS gmhA NC_004741.1 294258 294836 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 294258..294836 Shigella flexneri 2a str. 2457T 1076723 NP_836013.1 CDS yafJ NC_004741.1 295042 295809 D residues 1 to 255 of 255 are 99.60 pct identical to residues 1 to 255 of 255 from Escherichia coli K-12 : B0223; amidotransferase 295042..295809 Shigella flexneri 2a str. 2457T 1076724 NP_836014.1 CDS yafK NC_004741.1 295780 296520 R residues 1 to 246 of 246 are 99.59 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B0224; hypothetical protein complement(295780..296520) Shigella flexneri 2a str. 2457T 1076725 NP_836015.1 CDS yafL NC_004741.1 296871 297425 D residues 10 to 184 of 184 are 96.57 pct identical to residues 75 to 249 of 249 from Escherichia coli K-12 : B0227; lipoprotein 296871..297425 Shigella flexneri 2a str. 2457T 1076726 NP_836016.1 CDS yafM NC_004741.1 297601 298098 D residues 1 to 164 of 165 are 94.51 pct identical to residues 1 to 164 of 165 from Escherichia coli K-12 : B0228; hypothetical protein 297601..298098 Shigella flexneri 2a str. 2457T 1076728 NP_836017.1 CDS fhiA NC_004741.1 298315 300054 R residues 1 to 579 of 579 are 89.81 pct identical to residues 1 to 579 of 579 from Escherichia coli K-12 : B0229; flagellar biosynthetic protein FlhA complement(298315..300054) Shigella flexneri 2a str. 2457T 1080038 NP_836018.1 CDS mbhA NC_004741.1 299999 300784 D residues 1 to 261 of 261 are 98.46 pct identical to residues 1 to 261 of 261 from Escherichia coli K-12 : B0230; hypothetical protein 299999..300784 Shigella flexneri 2a str. 2457T 1076729 NP_836019.1 CDS dinP NC_004741.1 300855 301910 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 300855..301910 Shigella flexneri 2a str. 2457T 1076730 NP_836020.1 CDS yafN NC_004741.1 301962 302255 D residues 1 to 97 of 97 are 98.96 pct identical to residues 1 to 97 of 97 from Escherichia coli K-12 : B0232; antitoxin of the YafO-YafN toxin-antitoxin system 301962..302255 Shigella flexneri 2a str. 2457T 1076731 NP_836021.1 CDS yafO NC_004741.1 302258 302656 D YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function; toxin YafO 302258..302656 Shigella flexneri 2a str. 2457T 1076732 NP_836022.1 CDS yafP NC_004741.1 302666 303118 D residues 1 to 150 of 150 are 91.33 pct identical to residues 1 to 150 of 150 from Escherichia coli K-12 : B0234; hypothetical protein 302666..303118 Shigella flexneri 2a str. 2457T 1076733 NP_836023.1 CDS S0304 NC_004741.1 303364 304407 D mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 303364..304407 Shigella flexneri 2a str. 2457T 1076734 NP_836024.1 CDS prfH NC_004741.1 304523 304978 D catalyzes the release of newly synthesized polypeptide chains at the stop codons UAA and UGA; peptide chain release factor 2 304523..304978 Shigella flexneri 2a str. 2457T 1076735 NP_836025.1 CDS pepD NC_004741.1 305140 306597 R residues 1 to 485 of 485 are 96.08 pct identical to residues 1 to 485 of 485 from Escherichia coli K-12 : B0237; aminoacyl-histidine dipeptidase complement(305140..306597) Shigella flexneri 2a str. 2457T 1076736 NP_836026.1 CDS gpt NC_004741.1 306859 307317 D catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 306859..307317 Shigella flexneri 2a str. 2457T 1076737 NP_836027.1 CDS frsA NC_004741.1 307409 308653 D forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 307409..308653 Shigella flexneri 2a str. 2457T 1076738 NP_836028.1 CDS crl NC_004741.1 308711 309112 D involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 308711..309112 Shigella flexneri 2a str. 2457T 1076739 NP_836029.1 CDS phoE NC_004741.1 309151 310206 R residues 1 to 351 of 351 are 99.71 pct identical to residues 1 to 351 of 351 from Escherichia coli K-12 : B0241; outer membrane phosphoporin protein E complement(309151..310206) Shigella flexneri 2a str. 2457T 1076740 NP_836030.1 CDS S0311 NC_004741.1 310382 310657 D residues 1 to 91 of 91 are 97.80 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 310382..310657 Shigella flexneri 2a str. 2457T 1076741 NP_836031.1 CDS S0312 NC_004741.1 310576 311079 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 310576..311079 Shigella flexneri 2a str. 2457T 1076742 NP_836032.1 CDS proB NC_004741.1 311270 312373 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 311270..312373 Shigella flexneri 2a str. 2457T 1076743 NP_836033.1 CDS proA NC_004741.1 312385 313638 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 312385..313638 Shigella flexneri 2a str. 2457T 1076744 NP_836034.1 CDS S0316 NC_004741.1 313843 315006 R residues 1 to 387 of 387 are 98.19 pct identical to residues 1 to 387 of 387 from GenPept : >gb|AAB72135.1| (U82619) integrase [Shigella flexneri bacteriophage V]; phage integrase complement(313843..315006) Shigella flexneri 2a str. 2457T 1076746 NP_836035.1 CDS S0317 NC_004741.1 315192 315494 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 315192..315494 Shigella flexneri 2a str. 2457T 1076747 NP_836036.1 CDS S0318 NC_004741.1 315635 316348 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 315635..316348 Shigella flexneri 2a str. 2457T 1076748 NP_836037.1 CDS S0319 NC_004741.1 316401 317051 D residues 1 to 216 of 216 are 90.74 pct identical to residues 1 to 216 of 216 from GenPept : >gb|AAB72130.2| (U82619) unknown [Shigella flexneri bacteriophage V]; hypothetical protein 316401..317051 Shigella flexneri 2a str. 2457T 1076749 NP_836038.1 CDS S4801 NC_004741.1 316960 317421 D residues 1 to 138 of 153 are 95.65 pct identical to residues 1 to 138 of 167 from Genpept : >gb|AAF09028.1| (AF139596) unknown [Shigella flexneri]; phage tail fibre protein 316960..317421 Shigella flexneri 2a str. 2457T 1080981 NP_836039.1 CDS S4802 NC_004741.1 318229 319278 R residues 17 to 137 of 349 are 28.12 pct identical to residues 7 to 129 of 337 from Genpept : >gb|AAK80982.1|AE007801_6 (AE007801) O-actetyl transferase related protein [Clostridium acetobutylicum]; hypothetical protein complement(318229..319278) Shigella flexneri 2a str. 2457T 1076750 NP_836040.1 CDS S4808 NC_004741.1 319729 320919 D residues 1 to 406 of 406 are 62.62 pct identical to residues 4 to 407 of 407 from NRprotein_Feb03 : >ref|NP_085189.1| IS10 orf [Shigella flexneri] gb|AAK18345.1|AF348706_34 IS10 orf [Shigella flexneri] gb|AAL72480.1| hypothetical protein [Shigella flexneri 2a]; hypothetical protein 319729..320919 Shigella flexneri 2a str. 2457T 1076751 NP_836041.1 CDS gtrII NC_004741.1 321309 322769 R residues 1 to 486 of 486 are 81.68 pct identical to residues 1 to 486 of 486 from Genpept : >gb|AAC39273.1| (AF021347) glucosyl tranferase II [bacteriophage SfII]; glucosyl tranferase II complement(321309..322769) Shigella flexneri 2a str. 2457T 1076752 NP_836042.1 CDS gtrBI NC_004741.1 322766 323695 R residues 1 to 309 of 309 are 94.82 pct identical to residues 1 to 309 of 309 from GenPept : >gb|AAC39272.1| (AF021347) bactoprenol glucosyl transferase [bacteriophage SfII]; bactoprenol glucosyl transferase complement(322766..323695) Shigella flexneri 2a str. 2457T 1076753 NP_836043.1 CDS gtrAI NC_004741.1 323692 324054 R residues 1 to 120 of 120 are 89.99 pct identical to residues 1 to 120 of 120 from GenPept : >gb|AAB72134.1| (U82619) flippase [Shigella flexneri bacteriophage V]; flippase complement(323692..324054) Shigella flexneri 2a str. 2457T 1076754 NP_836044.1 CDS S0322 NC_004741.1 324316 324609 R residues 1 to 97 of 97 are 100.00 pct identical to residues 290 to 386 of 386 from GenPept : >gb|AAD10295.1| (U82084) integrase [bacteriophage SfX]; integrase fragment complement(324316..324609) Shigella flexneri 2a str. 2457T 1076755 NP_836045.1 CDS S0323 NC_004741.1 324718 325431 R residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB complement(324718..325431) Shigella flexneri 2a str. 2457T 1076757 NP_836046.1 CDS S0324 NC_004741.1 325572 325874 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA complement(325572..325874) Shigella flexneri 2a str. 2457T 1076758 NP_836047.1 CDS S0325 NC_004741.1 326060 327223 D residues 1 to 387 of 387 are 98.96 pct identical to residues 1 to 387 of 387 from GenPept : >gb|AAB72135.1| (U82619) integrase [Shigella flexneri bacteriophage V]; phage integrase 326060..327223 Shigella flexneri 2a str. 2457T 1076759 NP_836048.1 CDS S4804 NC_004741.1 327572 328744 D residues 39 to 379 of 390 are 28.05 pct identical to residues 15 to 359 of 397 from Genpept : >dbj|BAB50097.1| (AP003001) contains weak similarity to acetyltransferase [Mesorhizobium loti]; hypothetical protein 327572..328744 Shigella flexneri 2a str. 2457T 1076760 NP_836049.1 CDS S0326 NC_004741.1 329548 329988 R residues 1 to 146 of 146 are 99.31 pct identical to residues 127 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB complement(329548..329988) Shigella flexneri 2a str. 2457T 1076761 NP_836050.1 CDS S0327 NC_004741.1 330729 331349 R residues 1 to 206 of 206 are 100.00 pct identical to residues 1 to 206 of 206 from GenPept : >gb|AAD44736.1|AF141323_7 (AF141323) TnpC [Shigella flexneri]; IS629 orfB complement(330729..331349) Shigella flexneri 2a str. 2457T 1076762 NP_836051.1 CDS S0328 NC_004741.1 331711 331929 R residues 1 to 71 of 72 are 84.50 pct identical to residues 1 to 71 of 108 from GenPept : >gb|AAL72456.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629, orfA complement(331711..331929) Shigella flexneri 2a str. 2457T 1077809 NP_836052.1 CDS adrA NC_004741.1 332080 333195 D catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 332080..333195 Shigella flexneri 2a str. 2457T 1076603 NP_836053.1 CDS proC NC_004741.1 333212 334021 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(333212..334021) Shigella flexneri 2a str. 2457T 1076763 NP_836054.2 CDS yaiI NC_004741.1 334141 334599 D residues 1 to 192 of 192 are 93.22 pct identical to residues 1 to 192 of 192 from Escherichia coli K-12 : B0387; hypothetical protein 334141..334599 Shigella flexneri 2a str. 2457T 1076764 NP_836055.1 CDS aroL NC_004741.1 334782 335306 D type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 334782..335306 Shigella flexneri 2a str. 2457T 1076765 NP_836056.1 CDS yaiA NC_004741.1 335356 335547 D residues 1 to 63 of 63 are 100.00 pct identical to residues 1 to 63 of 63 from Escherichia coli K-12 : B0389; hypothetical protein 335356..335547 Shigella flexneri 2a str. 2457T 1076766 NP_836057.1 CDS aroM NC_004741.1 335805 336482 D residues 1 to 225 of 225 are 100.00 pct identical to residues 1 to 225 of 225 from Escherichia coli K-12 : B0390; regulated by aroR; hypothetical protein 335805..336482 Shigella flexneri 2a str. 2457T 1076767 NP_836058.1 CDS yaiE NC_004741.1 336554 336838 D residues 1 to 94 of 94 are 100.00 pct identical to residues 1 to 94 of 94 from Escherichia coli K-12 : B0391; hypothetical protein 336554..336838 Shigella flexneri 2a str. 2457T 1076768 NP_836059.1 CDS S0336 NC_004741.1 337047 337328 D residues 1 to 93 of 93 are 97.84 pct identical to residues 1 to 93 of 93 from Escherichia coli K-12 : B0392; hypothetical protein 337047..337328 Shigella flexneri 2a str. 2457T 1076769 NP_836060.1 CDS S0337 NC_004741.1 337325 337780 D ORF2; residues 1 to 144 of 151 are 99.30 pct identical to residues 1 to 144 of 149 from GenPept : >gb|AAG54739.1|AE005218_4 (AE005218) Z0491 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 337325..337780 Shigella flexneri 2a str. 2457T 1076770 NP_836061.1 CDS rdgC NC_004741.1 337858 338769 R Required for efficient pilin antigenic variation; recombination associated protein complement(337858..338769) Shigella flexneri 2a str. 2457T 1076772 NP_836062.2 CDS yajF NC_004741.1 338894 339787 D catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 338894..339787 Shigella flexneri 2a str. 2457T 1076773 NP_836063.1 CDS araJ NC_004741.1 339945 341126 R member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ complement(339945..341126) Shigella flexneri 2a str. 2457T 1076774 NP_836064.1 CDS sbcC NC_004741.1 341252 344395 R with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease subunit SbcC complement(341252..344395) Shigella flexneri 2a str. 2457T 1076775 NP_836065.1 CDS sbcD NC_004741.1 344392 345594 R with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease subunit SbcD complement(344392..345594) Shigella flexneri 2a str. 2457T 1076776 NP_836066.1 CDS phoB NC_004741.1 345784 346473 D two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 345784..346473 Shigella flexneri 2a str. 2457T 1076777 NP_836067.1 CDS phoR NC_004741.1 346531 347826 D membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 346531..347826 Shigella flexneri 2a str. 2457T 1076779 NP_836068.1 CDS brnQ NC_004741.1 348233 349552 D residues 1 to 439 of 439 are 93.39 pct identical to residues 1 to 439 of 439 from Escherichia coli K-12 : B0401; branched-chain amino acid aminotransferase 348233..349552 Shigella flexneri 2a str. 2457T 1076780 NP_836069.1 CDS proY NC_004741.1 349628 351001 D cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; proline-specific permease 349628..351001 Shigella flexneri 2a str. 2457T 1076781 NP_836070.1 CDS malZ NC_004741.1 351157 352974 D residues 1 to 605 of 605 are 98.84 pct identical to residues 1 to 605 of 605 from Escherichia coli K-12 : B0403; maltodextrin glucosidase 351157..352974 Shigella flexneri 2a str. 2457T 1076782 NP_836071.1 CDS queA NC_004741.1 353645 354715 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 353645..354715 Shigella flexneri 2a str. 2457T 1076784 NP_836072.1 CDS tgt NC_004741.1 354770 355897 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 354770..355897 Shigella flexneri 2a str. 2457T 1076785 NP_836073.1 CDS yajC NC_004741.1 355920 356252 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 355920..356252 Shigella flexneri 2a str. 2457T 1076786 NP_836074.1 CDS secD NC_004741.1 356280 358127 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 356280..358127 Shigella flexneri 2a str. 2457T 1076787 NP_836075.1 CDS secF NC_004741.1 358138 359109 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 358138..359109 Shigella flexneri 2a str. 2457T 1076788 NP_836076.1 CDS yajD NC_004741.1 359238 359585 D residues 1 to 115 of 115 are 100.00 pct identical to residues 1 to 115 of 115 from Escherichia coli K-12 : B0410; hypothetical protein 359238..359585 Shigella flexneri 2a str. 2457T 1076789 NP_836077.1 CDS tsx NC_004741.1 359762 360646 R residues 1 to 294 of 294 are 95.57 pct identical to residues 1 to 294 of 294 from Escherichia coli K-12 : B0411; receptor of phage t6 and colicin K; outer membrane protein Tsx complement(359762..360646) Shigella flexneri 2a str. 2457T 1076790 NP_836078.2 CDS yajI NC_004741.1 360944 361483 R residues 1 to 199 of 199 are 93.96 pct identical to residues 1 to 199 of 199 from Escherichia coli K-12 : B0412; hypothetical protein complement(360944..361483) Shigella flexneri 2a str. 2457T 1076791 NP_836079.1 CDS nrdR NC_004741.1 361634 362083 D residues 1 to 149 of 149 are 99.32 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B0413; transcriptional regulator NrdR 361634..362083 Shigella flexneri 2a str. 2457T 1076792 NP_836080.1 CDS ribD NC_004741.1 362087 363190 D riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 362087..363190 Shigella flexneri 2a str. 2457T 1076793 NP_836081.1 CDS ribH NC_004741.1 363279 363749 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 363279..363749 Shigella flexneri 2a str. 2457T 1076794 NP_836082.1 CDS nusB NC_004741.1 363769 364188 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 363769..364188 Shigella flexneri 2a str. 2457T 1076795 NP_836083.1 CDS thiL NC_004741.1 364266 365243 D catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 364266..365243 Shigella flexneri 2a str. 2457T 1076796 NP_836084.1 CDS pgpA NC_004741.1 365221 365739 D hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 365221..365739 Shigella flexneri 2a str. 2457T 1080979 NP_836085.1 CDS dxs NC_004741.1 366822 368684 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(366822..368684) Shigella flexneri 2a str. 2457T 1080980 NP_836086.1 CDS ispA NC_004741.1 368709 369608 R residues 1 to 299 of 299 are 95.98 pct identical to residues 1 to 299 of 299 from Escherichia coli K-12 : B0421; geranyltranstransferase complement(368709..369608) Shigella flexneri 2a str. 2457T 1076799 NP_836087.1 CDS xseB NC_004741.1 369608 369850 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(369608..369850) Shigella flexneri 2a str. 2457T 1076800 NP_836088.1 CDS yajK NC_004741.1 370056 371504 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 370056..371504 Shigella flexneri 2a str. 2457T 1076801 NP_836089.1 CDS thiJ NC_004741.1 371558 372154 R residues 1 to 198 of 198 are 97.97 pct identical to residues 1 to 198 of 198 from Escherichia coli K-12 : B0424; hypothetical protein complement(371558..372154) Shigella flexneri 2a str. 2457T 1076802 NP_836090.1 CDS apbA NC_004741.1 372111 373022 R ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase complement(372111..373022) Shigella flexneri 2a str. 2457T 1076803 NP_836091.1 CDS yajQ NC_004741.1 373190 373681 D nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 373190..373681 Shigella flexneri 2a str. 2457T 1076804 NP_836092.1 CDS S4809 NC_004741.1 373741 375471 R residues 1 to 575 of 576 are 48.69 pct identical to residues 1 to 575 of 576 from NRprotein_Feb03 : >ref|NP_460955.1| periplasmic protein [Salmonella typhimurium LT2] gb|AAL20914.1| periplasmic protein [Salmonella typhimurium LT2]; hypothetical protein complement(373741..375471) Shigella flexneri 2a str. 2457T 1076805 NP_836093.1 CDS S4810 NC_004741.1 375524 377677 R residues 1 to 713 of 717 are 51.59 pct identical to residues 1 to 717 of 720 from NRprotein_Feb03 : >ref|NP_405544.1| exported protein [Yersinia pestis] ref|NP_669630.1| hypothetical [Yersinia pestis KIM] pir||AF0242 probable exported protein YPO1989 [imported] - Yersinia pestis (strain CO92) emb|CAC90802.1; hypothetical protein complement(375524..377677) Shigella flexneri 2a str. 2457T 1076806 NP_836094.1 CDS S0372 NC_004741.1 377828 378103 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 377828..378103 Shigella flexneri 2a str. 2457T 1076807 NP_836095.1 CDS S4811 NC_004741.1 378231 378524 D residues 7 to 103 of 103 are 100.00 pct identical to residues 71 to 167 of 167 from NRprotein_Feb03 : >ref|NP_085209.1| IS1 transposase [Shigella flexneri] ref|NP_706317.1| IS1 transposase [Shigella flexneri 2a str. 301] ref|NP_707672.1| IS1 transposase [Shigella flexneri 2a str. 301] ref|NP_707862.1| IS1 transposase [Shigella flexneri 2a str. 301] ref|NP_708570.1| IS1 transposase [Shigella flexneri; IS1 orfB 378231..378524 Shigella flexneri 2a str. 2457T 1076808 NP_836096.1 CDS S4812 NC_004741.1 378572 378811 R residues 1 to 79 of 79 are 100.00 pct identical to residues 54 to 132 of 132 from NRprotein_Feb03 : >ref|NP_706318.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN42025.1|AE015069_8 orf, conserved hypothetical protein [Shigella flexneri 2a str. 301]; hypothetical protein complement(378572..378811) Shigella flexneri 2a str. 2457T 1076809 NP_836097.1 CDS S0373 NC_004741.1 379105 379416 R ORF2; residues 15 to 95 of 103 are 35.80 pct identical to residues 10 to 90 of 95 from GenPept : >dbj|BAA84915.1| (AB024946) orf80 [Escherichia coli]; hypothetical protein complement(379105..379416) Shigella flexneri 2a str. 2457T 1076810 NP_836098.1 CDS cyoE NC_004741.1 379600 380487 R converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase complement(379600..380487) Shigella flexneri 2a str. 2457T 1076811 NP_836099.1 CDS cyoD NC_004741.1 380502 380831 R residues 1 to 109 of 109 are 100.00 pct identical to residues 1 to 109 of 109 from Escherichia coli K-12 : B0429; cytochrome o ubiquinol oxidase subunit IV complement(380502..380831) Shigella flexneri 2a str. 2457T 1076812 NP_836100.1 CDS cyoC NC_004741.1 380831 381445 R residues 25 to 204 of 204 are 100.00 pct identical to residues 25 to 204 of 204 from Escherichia coli K-12 : B0430; cytochrome o ubiquinol oxidase subunit III complement(380831..381445) Shigella flexneri 2a str. 2457T 1076815 NP_836101.1 CDS S0379 NC_004741.1 383978 385027 R residues 1 to 349 of 349 are 99.71 pct identical to residues 2 to 350 of 350 from GenPept : >gb|AAK18526.1|AF348706_215 (AF348706) IS orf [Shigella flexneri]; ISSfl3 orfD complement(383978..385027) Shigella flexneri 2a str. 2457T 1076818 NP_836102.2 CDS S0380 NC_004741.1 385243 385431 R residues 1 to 59 of 62 are 88.13 pct identical to residues 273 to 331 of 533 from GenPept : >gb|AAL72376.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; ISSfl3 orfC complement(385243..385431) Shigella flexneri 2a str. 2457T 1076819 NP_836103.1 CDS S0381 NC_004741.1 385428 385562 R residues 1 to 36 of 44 are 100.00 pct identical to residues 1 to 36 of 533 from GenPept : >gb|AAL72472.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; ISSfl3 orfC complement(385428..385562) Shigella flexneri 2a str. 2457T 1076820 NP_836104.1 CDS S0382 NC_004741.1 385582 385929 R residues 1 to 115 of 115 are 100.00 pct identical to residues 1 to 115 of 115 from GenPept : >gb|AAL72465.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfB complement(385582..385929) Shigella flexneri 2a str. 2457T 1076821 NP_836105.1 CDS S0383 NC_004741.1 385926 386423 R residues 1 to 165 of 165 are 98.78 pct identical to residues 60 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA complement(385926..386423) Shigella flexneri 2a str. 2457T 1076822 NP_836106.1 CDS ampG NC_004741.1 386970 388445 R in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter complement(386970..388445) Shigella flexneri 2a str. 2457T 1076823 NP_836107.2 CDS yajG NC_004741.1 388489 389067 R residues 1 to 226 of 226 are 93.80 pct identical to residues 1 to 226 of 226 from Escherichia coli K-12 : B0434; hypothetical protein complement(388489..389067) Shigella flexneri 2a str. 2457T 1076824 NP_836108.2 CDS bolA NC_004741.1 389372 389689 D positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 389372..389689 Shigella flexneri 2a str. 2457T 1076825 NP_836109.1 CDS tig NC_004741.1 390033 391331 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 390033..391331 Shigella flexneri 2a str. 2457T 1076826 NP_836110.1 CDS clpP NC_004741.1 391578 392201 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 391578..392201 Shigella flexneri 2a str. 2457T 1076827 NP_836111.1 CDS clpX NC_004741.1 392327 393601 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 392327..393601 Shigella flexneri 2a str. 2457T 1076828 NP_836112.1 CDS lon NC_004741.1 393789 396143 D residues 1 to 784 of 784 are 97.83 pct identical to residues 1 to 784 of 784 from Escherichia coli K-12 : B0439; DNA-binding ATP-dependent protease La 393789..396143 Shigella flexneri 2a str. 2457T 1076829 NP_836113.1 CDS hupB NC_004741.1 396352 396624 D histone-like DNA-binding protein; transcriptional regulator HU subunit beta 396352..396624 Shigella flexneri 2a str. 2457T 1076830 NP_836114.1 CDS ybaU NC_004741.1 396816 398687 D residues 1 to 623 of 623 are 96.95 pct identical to residues 1 to 623 of 623 from Escherichia coli K-12 : B0441; peptidyl-prolyl cis-trans isomerase (rotamase D) 396816..398687 Shigella flexneri 2a str. 2457T 1076831 NP_836115.1 CDS ybaV NC_004741.1 398838 399209 D residues 1 to 123 of 123 are 85.36 pct identical to residues 1 to 123 of 123 from Escherichia coli K-12 : B0442; hypothetical protein 398838..399209 Shigella flexneri 2a str. 2457T 1076832 NP_836116.1 CDS ybaW NC_004741.1 399303 399701 D residues 1 to 132 of 132 are 89.39 pct identical to residues 1 to 132 of 132 from Escherichia coli K-12 : B0443; hypothetical protein 399303..399701 Shigella flexneri 2a str. 2457T 1076833 NP_836117.1 CDS ybaX NC_004741.1 399753 400448 R YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC complement(399753..400448) Shigella flexneri 2a str. 2457T 1076834 NP_836118.1 CDS cof NC_004741.1 402293 403123 D residues 1 to 276 of 276 are 98.18 pct identical to residues 1 to 276 of 276 from Escherichia coli K-12 : B0446; hypothetical protein 402293..403123 Shigella flexneri 2a str. 2457T 1076837 NP_836119.1 CDS ybaO NC_004741.1 403190 403735 D residues 1 to 181 of 181 are 98.34 pct identical to residues 1 to 181 of 181 from Escherichia coli K-12 : B0447; LRP-like transcriptional regulator 403190..403735 Shigella flexneri 2a str. 2457T 1076838 NP_836120.1 CDS mdlA NC_004741.1 403765 405537 D residues 1 to 590 of 590 are 96.61 pct identical to residues 1 to 590 of 590 from Escherichia coli K-12 : B0448; multidrug transporter membrane\ATP-binding components 403765..405537 Shigella flexneri 2a str. 2457T 1076839 NP_836121.1 CDS mdlB NC_004741.1 405530 407311 D residues 1 to 593 of 593 are 91.73 pct identical to residues 1 to 593 of 593 from Escherichia coli K-12 : B0449; multidrug transporter membrane\ATP-binding components 405530..407311 Shigella flexneri 2a str. 2457T 1076840 NP_836122.1 CDS glnK NC_004741.1 407492 407830 D indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 407492..407830 Shigella flexneri 2a str. 2457T 1076841 NP_836123.1 CDS amtB NC_004741.1 407860 409146 D residues 1 to 428 of 428 are 82.94 pct identical to residues 1 to 428 of 428 from Escherichia coli K-12 : B0451; ammonium transporter 407860..409146 Shigella flexneri 2a str. 2457T 1076842 NP_836124.1 CDS tesB NC_004741.1 409195 410055 R residues 1 to 286 of 286 are 96.15 pct identical to residues 1 to 286 of 286 from Escherichia coli K-12 : B0452; acyl-CoA thioesterase II complement(409195..410055) Shigella flexneri 2a str. 2457T 1080558 NP_836125.1 CDS ybaY NC_004741.1 410273 410845 D residues 1 to 190 of 190 are 75.26 pct identical to residues 1 to 190 of 190 from Escherichia coli K-12 : B0453; involved in glycoprotein/polysaccharide metabolism; hypothetical protein 410273..410845 Shigella flexneri 2a str. 2457T 1076843 NP_836126.1 CDS S0405 NC_004741.1 410956 412284 D residues 1 to 442 of 442 are 99.32 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 410956..412284 Shigella flexneri 2a str. 2457T 1076844 NP_836127.1 CDS ybaZ NC_004741.1 412314 412625 R residues 1 to 103 of 103 are 100.00 pct identical to residues 27 to 129 of 129 from Escherichia coli K-12 : B0454; hypothetical protein complement(412314..412625) Shigella flexneri 2a str. 2457T 1076845 NP_836128.1 CDS ybaA NC_004741.1 413004 413357 D residues 1 to 117 of 117 are 100.00 pct identical to residues 1 to 117 of 117 from Escherichia coli K-12 : B0456; hypothetical protein 413004..413357 Shigella flexneri 2a str. 2457T 1076847 NP_836129.1 CDS ylaB NC_004741.1 413399 414949 R residues 1 to 516 of 516 are 94.37 pct identical to residues 3 to 518 of 518 from Escherichia coli K-12 : B0457; hypothetical protein complement(413399..414949) Shigella flexneri 2a str. 2457T 1076848 NP_836130.1 CDS ylaC NC_004741.1 415113 415583 R residues 1 to 156 of 156 are 100.00 pct identical to residues 14 to 169 of 169 from Escherichia coli K-12 : B0458; hypothetical protein complement(415113..415583) Shigella flexneri 2a str. 2457T 1076849 NP_836131.1 CDS hha NC_004741.1 416422 416640 R with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein complement(416422..416640) Shigella flexneri 2a str. 2457T 1076851 NP_836132.1 CDS ybaJ NC_004741.1 416666 417040 R residues 1 to 124 of 124 are 99.19 pct identical to residues 1 to 124 of 124 from Escherichia coli K-12 : B0461; hypothetical protein complement(416666..417040) Shigella flexneri 2a str. 2457T 1076852 NP_836133.1 CDS acrB NC_004741.1 417586 420735 R residues 1 to 1049 of 1049 are 94.47 pct identical to residues 1 to 1049 of 1049 from Escherichia coli K-12 : B0462; acriflavine resistance protein complement(417586..420735) Shigella flexneri 2a str. 2457T 1076853 NP_836134.1 CDS acrA NC_004741.1 420758 421951 R residues 1 to 397 of 397 are 90.17 pct identical to residues 1 to 397 of 397 from Escherichia coli K-12 : B0463; acriflavin resistance protein AcrA precursor complement(420758..421951) Shigella flexneri 2a str. 2457T 1076854 NP_836135.1 CDS acrR NC_004741.1 422093 422740 D regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 422093..422740 Shigella flexneri 2a str. 2457T 1076855 NP_836136.1 CDS aefA NC_004741.1 422868 426230 D small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 422868..426230 Shigella flexneri 2a str. 2457T 1076856 NP_836137.1 CDS ybaM NC_004741.1 426442 426603 R residues 1 to 53 of 53 are 98.11 pct identical to residues 1 to 53 of 53 from Escherichia coli K-12 : B0466; hypothetical protein complement(426442..426603) Shigella flexneri 2a str. 2457T 1076857 NP_836138.1 CDS priC NC_004741.1 426617 427144 R PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' complement(426617..427144) Shigella flexneri 2a str. 2457T 1076858 NP_836139.1 CDS ybaN NC_004741.1 427214 427591 D residues 1 to 125 of 125 are 86.40 pct identical to residues 1 to 125 of 125 from Escherichia coli K-12 : B0468; hypothetical protein 427214..427591 Shigella flexneri 2a str. 2457T 1076859 NP_836140.1 CDS apt NC_004741.1 427744 428295 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 427744..428295 Shigella flexneri 2a str. 2457T 1076860 NP_836141.1 CDS dnaX NC_004741.1 428424 430349 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 428424..430349 Shigella flexneri 2a str. 2457T 1076861 NP_836142.1 CDS ybaB NC_004741.1 430402 430731 D residues 1 to 109 of 109 are 70.64 pct identical to residues 1 to 109 of 109 from Escherichia coli K-12 : B0471; hypothetical protein 430402..430731 Shigella flexneri 2a str. 2457T 1076862 NP_836143.1 CDS recR NC_004741.1 430731 431336 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 430731..431336 Shigella flexneri 2a str. 2457T 1076863 NP_836144.1 CDS htpG NC_004741.1 431446 433320 D molecular chaperone; heat shock protein 90 431446..433320 Shigella flexneri 2a str. 2457T 1076864 NP_836145.1 CDS adk NC_004741.1 433501 434145 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 433501..434145 Shigella flexneri 2a str. 2457T 1080956 NP_836146.1 CDS hemH NC_004741.1 434277 435239 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 434277..435239 Shigella flexneri 2a str. 2457T 1080922 NP_836147.1 CDS ybaC NC_004741.1 435377 436195 R residues 1 to 272 of 272 are 92.64 pct identical to residues 1 to 272 of 319 from Escherichia coli K-12 : B0476; lipase complement(435377..436195) Shigella flexneri 2a str. 2457T 1076865 NP_836148.1 CDS gsk NC_004741.1 436347 437651 D residues 1 to 434 of 434 are 96.77 pct identical to residues 1 to 434 of 434 from Escherichia coli K-12 : B0477; inosine-guanosine kinase 436347..437651 Shigella flexneri 2a str. 2457T 1076866 NP_836149.1 CDS ybaL NC_004741.1 437784 439460 R YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein complement(437784..439460) Shigella flexneri 2a str. 2457T 1076867 NP_836150.1 CDS fsr NC_004741.1 439698 440918 R residues 1 to 406 of 406 are 77.83 pct identical to residues 1 to 406 of 406 from Escherichia coli K-12 : B0479; fosmidomycin resistance protein complement(439698..440918) Shigella flexneri 2a str. 2457T 1076868 NP_836151.1 CDS ushA NC_004741.1 441136 442788 D catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor 441136..442788 Shigella flexneri 2a str. 2457T 1076869 NP_836152.1 CDS ybaK NC_004741.1 442825 443304 R residues 1 to 159 of 159 are 91.82 pct identical to residues 1 to 159 of 159 from Escherichia coli K-12 : B0481; hypothetical protein complement(442825..443304) Shigella flexneri 2a str. 2457T 1076870 NP_836153.1 CDS ybaP NC_004741.1 443508 444302 R residues 1 to 264 of 264 are 100.00 pct identical to residues 1 to 264 of 264 from Escherichia coli K-12 : B0482; ligase complement(443508..444302) Shigella flexneri 2a str. 2457T 1076872 NP_836154.1 CDS ybaQ NC_004741.1 444386 444781 D residues 1 to 131 of 131 are 97.70 pct identical to residues 1 to 131 of 131 from Escherichia coli K-12 : B0483; hypothetical protein 444386..444781 Shigella flexneri 2a str. 2457T 1076873 NP_836155.1 CDS copA NC_004741.1 444996 447500 R residues 1 to 834 of 834 are 93.64 pct identical to residues 1 to 834 of 834 from Escherichia coli K-12 : B0484; copper exporting ATPase complement(444996..447500) Shigella flexneri 2a str. 2457T 1076874 NP_836156.1 CDS ybaS NC_004741.1 447762 448694 D catalyzes the formation of glutamate from glutamine; glutaminase 447762..448694 Shigella flexneri 2a str. 2457T 1076875 NP_836157.1 CDS ybaT NC_004741.1 448697 449989 D residues 1 to 430 of 430 are 86.51 pct identical to residues 1 to 430 of 430 from Escherichia coli K-12 : B0486; amino acid/amine transport protein 448697..449989 Shigella flexneri 2a str. 2457T 1076876 NP_836158.1 CDS ybbI NC_004741.1 450114 450521 D activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 450114..450521 Shigella flexneri 2a str. 2457T 1076877 NP_836159.1 CDS ybbJ NC_004741.1 450522 450977 R residues 1 to 151 of 151 are 81.45 pct identical to residues 1 to 151 of 151 from Escherichia coli K-12 : B0488; hypothetical protein complement(450522..450977) Shigella flexneri 2a str. 2457T 1076878 NP_836160.1 CDS ybbK NC_004741.1 450977 451894 R residues 1 to 305 of 305 are 95.40 pct identical to residues 1 to 305 of 305 from Escherichia coli K-12 : B0489; protease complement(450977..451894) Shigella flexneri 2a str. 2457T 1076879 NP_836161.1 CDS ybbL NC_004741.1 452040 452717 D residues 1 to 225 of 225 are 98.66 pct identical to residues 1 to 225 of 225 from Escherichia coli K-12 : B0490; ABC transporter ATP-binding protein 452040..452717 Shigella flexneri 2a str. 2457T 1076880 NP_836162.1 CDS ybbM NC_004741.1 452677 453483 D residues 1 to 268 of 268 are 89.55 pct identical to residues 1 to 268 of 268 from Escherichia coli K-12 : B0491; metal resistance protein 452677..453483 Shigella flexneri 2a str. 2457T 1076881 NP_836163.1 CDS ybbN NC_004741.1 453546 454436 R residues 1 to 296 of 296 are 95.60 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 : B0492; thioredoxin-like protein complement(453546..454436) Shigella flexneri 2a str. 2457T 1076882 NP_836164.1 CDS ybbO NC_004741.1 454461 455270 R residues 1 to 269 of 269 are 98.51 pct identical to residues 1 to 269 of 269 from Escherichia coli K-12 : B0493; short chain dehydrogenase complement(454461..455270) Shigella flexneri 2a str. 2457T 1076883 NP_836165.1 CDS ybbA NC_004741.1 455853 456539 D residues 1 to 228 of 228 are 100.00 pct identical to residues 1 to 228 of 228 from Escherichia coli K-12 : B0495; ABC transporter ATP-binding protein 455853..456539 Shigella flexneri 2a str. 2457T 1076886 NP_836166.1 CDS ybbB NC_004741.1 459664 460758 R catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase complement(459664..460758) Shigella flexneri 2a str. 2457T 1076888 NP_836167.1 CDS ybbS NC_004741.1 460827 461753 R activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS complement(460827..461753) Shigella flexneri 2a str. 2457T 1076889 NP_836168.1 CDS ybbT NC_004741.1 461983 462465 D catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 461983..462465 Shigella flexneri 2a str. 2457T 1076890 NP_836169.1 CDS ybbU NC_004741.1 462543 463358 D regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 462543..463358 Shigella flexneri 2a str. 2457T 1076891 NP_836170.1 CDS gcl NC_004741.1 463448 465229 D catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 463448..465229 Shigella flexneri 2a str. 2457T 1076892 NP_836171.1 CDS gip NC_004741.1 465242 465523 D residues 1 to 93 of 93 are 97.84 pct identical to residues 1 to 93 of 258 from Escherichia coli K-12 : B0508; glyoxylate-induced protein 465242..465523 Shigella flexneri 2a str. 2457T 1076893 NP_836172.1 CDS S0455 NC_004741.1 465534 466037 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(465534..466037) Shigella flexneri 2a str. 2457T 1076894 NP_836173.1 CDS S0456 NC_004741.1 465956 466231 R residues 1 to 91 of 91 are 97.80 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(465956..466231) Shigella flexneri 2a str. 2457T 1076895 NP_836174.1 CDS ylbA NC_004741.1 466260 466931 R residues 1 to 217 of 223 are 91.70 pct identical to residues 1 to 217 of 261 from Escherichia coli K-12 : B0515; hypothetical protein complement(466260..466931) Shigella flexneri 2a str. 2457T 1076896 NP_836175.2 CDS ylbB NC_004741.1 466942 468231 R allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase complement(466942..468231) Shigella flexneri 2a str. 2457T 1076897 NP_836176.1 CDS arcC NC_004741.1 468821 469714 D forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate; carbamate kinase 468821..469714 Shigella flexneri 2a str. 2457T 1076899 NP_836177.1 CDS purK NC_004741.1 469852 470919 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(469852..470919) Shigella flexneri 2a str. 2457T 1076900 NP_836178.1 CDS purE NC_004741.1 470916 471425 R Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit complement(470916..471425) Shigella flexneri 2a str. 2457T 1076901 NP_836179.1 CDS ybbF NC_004741.1 471543 472265 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(471543..472265) Shigella flexneri 2a str. 2457T 1076902 NP_836180.1 CDS ppiB NC_004741.1 472268 472762 R residues 1 to 164 of 164 are 99.39 pct identical to residues 1 to 164 of 164 from Escherichia coli K-12 : B0525; peptidyl-prolyl cis-trans isomerase B (rotamase B) complement(472268..472762) Shigella flexneri 2a str. 2457T 1076903 NP_836181.1 CDS cysS NC_004741.1 472936 474321 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 472936..474321 Shigella flexneri 2a str. 2457T 1076904 NP_836182.1 CDS ybcI NC_004741.1 474357 474866 R residues 1 to 149 of 169 are 85.62 pct identical to residues 1 to 153 of 173 from Escherichia coli K-12 : B0527; hypothetical protein complement(474357..474866) Shigella flexneri 2a str. 2457T 1076905 NP_836183.2 CDS ybcJ NC_004741.1 474974 475186 R residues 1 to 77 of 77 are 98.70 pct identical to residues 1 to 77 of 77 from Escherichia coli K-12 : B0528; hypothetical protein complement(474974..475186) Shigella flexneri 2a str. 2457T 1076906 NP_836184.1 CDS folD NC_004741.1 475188 476054 R residues 1 to 288 of 288 are 99.30 pct identical to residues 1 to 288 of 288 from Escherichia coli K-12 : B0529; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(475188..476054) Shigella flexneri 2a str. 2457T 1076907 NP_836185.1 CDS sfmA NC_004741.1 476502 477077 D residues 1 to 191 of 191 are 90.57 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B0530; fimbrial-like protein 476502..477077 Shigella flexneri 2a str. 2457T 1076908 NP_836186.1 CDS sfmC NC_004741.1 477297 477989 D residues 13 to 230 of 230 are 90.82 pct identical to residues 13 to 230 of 230 from Escherichia coli K-12 : B0531; chaperone 477297..477989 Shigella flexneri 2a str. 2457T 1076909 NP_836187.1 CDS S0471 NC_004741.1 478532 479035 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(478532..479035) Shigella flexneri 2a str. 2457T 1076910 NP_836188.1 CDS S0472 NC_004741.1 478954 479229 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(478954..479229) Shigella flexneri 2a str. 2457T 1076911 NP_836189.1 CDS envY NC_004741.1 479858 480619 R residues 1 to 253 of 253 are 92.09 pct identical to residues 1 to 253 of 253 from Escherichia coli K-12 : B0566; involved in thermoregulation of porin biosynthesis; envelope protein complement(479858..480619) Shigella flexneri 2a str. 2457T 1076915 NP_836190.1 CDS ybcH NC_004741.1 480802 481692 R residues 1 to 296 of 296 are 93.24 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 : B0567; hypothetical protein complement(480802..481692) Shigella flexneri 2a str. 2457T 1076916 NP_836191.1 CDS ybcZ NC_004741.1 487035 488477 R residues 1 to 480 of 480 are 88.95 pct identical to residues 1 to 480 of 480 from Escherichia coli K-12 : B0570; sensor kinase CusS complement(487035..488477) Shigella flexneri 2a str. 2457T 1076919 NP_836192.1 CDS ylcA NC_004741.1 488467 489150 R response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR complement(488467..489150) Shigella flexneri 2a str. 2457T 1076921 NP_836193.1 CDS ylcB NC_004741.1 489307 490689 D with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 489307..490689 Shigella flexneri 2a str. 2457T 1076922 NP_836194.1 CDS ylcC NC_004741.1 490713 491045 D residues 1 to 110 of 110 are 99.09 pct identical to residues 1 to 110 of 110 from Escherichia coli K-12 : B0573; periplasmic copper-binding protein 490713..491045 Shigella flexneri 2a str. 2457T 1076923 NP_836195.1 CDS S0484 NC_004741.1 491986 492309 D residues 3 to 104 of 107 are 42.85 pct identical to residues 16 to 120 of 409 from GenPept : >gb|AAF28112.1|AF153317_4 (AF153317) integrase [Shigella dysenteriae]; IntA 491986..492309 Shigella flexneri 2a str. 2457T 1076925 NP_836196.1 CDS S0485 NC_004741.1 492349 492969 R residues 1 to 206 of 206 are 100.00 pct identical to residues 1 to 206 of 206 from GenPept : >gb|AAD44736.1|AF141323_7 (AF141323) TnpC [Shigella flexneri]; partial; IS629 orfB complement(492349..492969) Shigella flexneri 2a str. 2457T 1078534 NP_836197.1 CDS S0486 NC_004741.1 493232 493558 R residues 1 to 108 of 108 are 89.81 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72456.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA complement(493232..493558) Shigella flexneri 2a str. 2457T 1076926 NP_836198.1 CDS S0487 NC_004741.1 494699 495490 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfB protein complement(494699..495490) Shigella flexneri 2a str. 2457T 1076927 NP_836199.1 CDS S0488 NC_004741.1 495562 495972 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(495562..495972) Shigella flexneri 2a str. 2457T 1076928 NP_836200.1 CDS ybdE NC_004741.1 496745 499888 D residues 1 to 1046 of 1047 are 96.36 pct identical to residues 1 to 1046 of 1047 from Escherichia coli K-12 : B0575; inner membrane component for iron transport 496745..499888 Shigella flexneri 2a str. 2457T 1076929 NP_836201.1 CDS pheP NC_004741.1 499989 501365 D residues 1 to 458 of 458 are 89.95 pct identical to residues 1 to 458 of 458 from Escherichia coli K-12 : B0576; phenylalanine transporter 499989..501365 Shigella flexneri 2a str. 2457T 1076930 NP_836202.1 CDS ybdG NC_004741.1 501433 502680 R residues 1 to 415 of 415 are 97.10 pct identical to residues 1 to 415 of 415 from Escherichia coli K-12 : B0577; transporter complement(501433..502680) Shigella flexneri 2a str. 2457T 1076931 NP_836203.1 CDS nfnB NC_004741.1 502788 503441 R catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase complement(502788..503441) Shigella flexneri 2a str. 2457T 1077000 NP_836204.1 CDS ybdF NC_004741.1 503535 503903 R residues 1 to 122 of 122 are 99.18 pct identical to residues 1 to 122 of 122 from Escherichia coli K-12 : B0579; hypothetical protein complement(503535..503903) Shigella flexneri 2a str. 2457T 1076932 NP_836205.1 CDS ybdJ NC_004741.1 503968 504216 R residues 1 to 82 of 82 are 78.04 pct identical to residues 1 to 82 of 82 from Escherichia coli K-12 : B0580; hypothetical protein complement(503968..504216) Shigella flexneri 2a str. 2457T 1076933 NP_836206.1 CDS ybdK NC_004741.1 504282 505400 R ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase complement(504282..505400) Shigella flexneri 2a str. 2457T 1076934 NP_836207.1 CDS IS103 NC_004741.1 505832 506353 D residues 1 to 173 of 173 are 100.00 pct identical to residues 1 to 173 of 173 from GenPept : >gb|AAB18534.1| (U00039) orfA in IS150 [Escherichia coli]; IS103 orf 505832..506353 Shigella flexneri 2a str. 2457T 1077940 NP_836208.1 CDS S0498 NC_004741.1 506350 506781 D residues 1 to 117 of 143 are 99.14 pct identical to residues 1 to 117 of 283 from GenPept : >gb|AAB18535.2| (U00039) orfB in IS150 [Escherichia coli]; IS150 orfB 506350..506781 Shigella flexneri 2a str. 2457T 1076935 NP_836209.1 CDS S0499 NC_004741.1 507298 507450 D residues 1 to 50 of 50 are 95.99 pct identical to residues 34 to 83 of 83 from GenPept : >gb|AAG54916.1|AE005238_2 (AE005238) Z0722 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 507298..507450 Shigella flexneri 2a str. 2457T 1076797 NP_836210.1 CDS S0500 NC_004741.1 507702 507953 D residues 1 to 83 of 83 are 97.59 pct identical to residues 1 to 83 of 83 from GenPept : >gb|AAG54916.1|AE005238_2 (AE005238) Z0722 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 507702..507953 Shigella flexneri 2a str. 2457T 1080978 NP_836211.1 CDS entD NC_004741.1 508075 508704 R residues 1 to 209 of 209 are 87.55 pct identical to residues 1 to 209 of 209 from Escherichia coli K-12 : B0583; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex complement(508075..508704) Shigella flexneri 2a str. 2457T 1076936 NP_836212.1 CDS fepA NC_004741.1 508870 511110 R Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA complement(508870..511110) Shigella flexneri 2a str. 2457T 1076938 NP_836213.1 CDS fes NC_004741.1 511353 512555 D residues 27 to 400 of 400 are 98.12 pct identical to residues 1 to 374 of 374 from Escherichia coli K-12 : B0585; enterobactin/ferric enterobactin esterase 511353..512555 Shigella flexneri 2a str. 2457T 1076939 NP_836214.1 CDS entF NC_004741.1 512773 516618 D with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 512773..516618 Shigella flexneri 2a str. 2457T 1076940 NP_836215.1 CDS S0505 NC_004741.1 516702 516977 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 516702..516977 Shigella flexneri 2a str. 2457T 1080988 NP_836216.1 CDS S0506 NC_004741.1 516896 517399 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 516896..517399 Shigella flexneri 2a str. 2457T 1076572 NP_836217.1 CDS fepC NC_004741.1 518740 519555 R with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein complement(518740..519555) Shigella flexneri 2a str. 2457T 1076943 NP_836218.1 CDS fepG NC_004741.1 519552 520544 R with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease complement(519552..520544) Shigella flexneri 2a str. 2457T 1076944 NP_836219.1 CDS fepD NC_004741.1 520541 521557 R with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein complement(520541..521557) Shigella flexneri 2a str. 2457T 1076945 NP_836220.1 CDS ybdA NC_004741.1 521656 522888 D protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 521656..522888 Shigella flexneri 2a str. 2457T 1076946 NP_836221.1 CDS fepB NC_004741.1 522892 523848 R with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein complement(522892..523848) Shigella flexneri 2a str. 2457T 1076947 NP_836222.1 CDS entE NC_004741.1 525325 526935 D bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 525325..526935 Shigella flexneri 2a str. 2457T 1076948 NP_836223.1 CDS entB NC_004741.1 526949 527806 D residues 1 to 285 of 285 are 99.64 pct identical to residues 1 to 285 of 285 from Escherichia coli K-12 : B0595; 2,3-dihydro-2,3-dihydroxybenzoate synthetase 526949..527806 Shigella flexneri 2a str. 2457T 1076949 NP_836224.1 CDS entA NC_004741.1 527806 528552 D catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 527806..528552 Shigella flexneri 2a str. 2457T 1076950 NP_836225.1 CDS ybdB NC_004741.1 528555 528968 D residues 1 to 137 of 137 are 90.51 pct identical to residues 1 to 137 of 137 from Escherichia coli K-12 : B0597; hypothetical protein 528555..528968 Shigella flexneri 2a str. 2457T 1076951 NP_836226.1 CDS cstA NC_004741.1 529149 531254 D residues 1 to 701 of 701 are 90.58 pct identical to residues 1 to 701 of 701 from Escherichia coli K-12 : B0598; carbon starvation protein 529149..531254 Shigella flexneri 2a str. 2457T 1076952 NP_836227.1 CDS ybdH NC_004741.1 531643 532731 R member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein complement(531643..532731) Shigella flexneri 2a str. 2457T 1076953 NP_836228.1 CDS ybdL NC_004741.1 532840 534000 D catalyzes the transfer of an amino moiety; aminotransferase 532840..534000 Shigella flexneri 2a str. 2457T 1076954 NP_836229.1 CDS S0522 NC_004741.1 534520 535146 R residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB complement(534520..535146) Shigella flexneri 2a str. 2457T 1076956 NP_836230.1 CDS S0523 NC_004741.1 535386 535688 R residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA complement(535386..535688) Shigella flexneri 2a str. 2457T 1076958 NP_836231.1 CDS S0526 NC_004741.1 536938 537216 D residues 1 to 92 of 92 are 92.39 pct identical to residues 3 to 94 of 94 from GenPept : >gb|AAG53987.1|AF327445_1 (AF327445) transposase A [Pantoea agglomerans]; ISEhe3 orfA 536938..537216 Shigella flexneri 2a str. 2457T 1076960 NP_836232.1 CDS S0527 NC_004741.1 537273 538085 D residues 1 to 270 of 270 are 95.92 pct identical to residues 10 to 279 of 279 from GenPept : >gb|AAG53988.1|AF327445_2 (AF327445) transposase B [Pantoea agglomerans]; ISEhe3 orfB 537273..538085 Shigella flexneri 2a str. 2457T 1076961 NP_836233.2 CDS dsbG NC_004741.1 539566 540312 R Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase complement(539566..540312) Shigella flexneri 2a str. 2457T 1076962 NP_836234.1 CDS ahpC NC_004741.1 540684 541247 D with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase subunit C 540684..541247 Shigella flexneri 2a str. 2457T 1076966 NP_836235.1 CDS ahpF NC_004741.1 541462 543057 D residues 1 to 531 of 531 are 95.29 pct identical to residues 1 to 531 of 531 from Escherichia coli K-12 : B0606; involved in detoxification of hydroperoxides; alkyl hydroperoxide reductase, F52a subunit 541462..543057 Shigella flexneri 2a str. 2457T 1078851 NP_836236.1 CDS ybdQ NC_004741.1 543178 543606 R residues 1 to 142 of 142 are 98.59 pct identical to residues 1 to 142 of 142 from Escherichia coli K-12 : B0607; hypothetical protein complement(543178..543606) Shigella flexneri 2a str. 2457T 1076967 NP_836237.1 CDS ybdR NC_004741.1 543827 545065 D residues 1 to 412 of 412 are 98.78 pct identical to residues 1 to 412 of 412 from Escherichia coli K-12 : B0608; oxidoreductase 543827..545065 Shigella flexneri 2a str. 2457T 1076968 NP_836238.1 CDS S0533 NC_004741.1 545146 545607 D residues 1 to 147 of 147 are 100.00 pct identical to residues 7 to 153 of 153 from Escherichia coli K-12 : B0609; hypothetical protein 545146..545607 Shigella flexneri 2a str. 2457T 1076969 NP_836239.1 CDS rnk NC_004741.1 545296 545706 R Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator complement(545296..545706) Shigella flexneri 2a str. 2457T 1076970 NP_836240.1 CDS rna NC_004741.1 545935 546759 R residues 7 to 274 of 274 are 91.79 pct identical to residues 1 to 268 of 268 from Escherichia coli K-12 : B0611; cleaves phosphodiester bond between any two nucleotides; ribonuclease I complement(545935..546759) Shigella flexneri 2a str. 2457T 1076971 NP_836241.1 CDS citG NC_004741.1 548368 549246 R catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase complement(548368..549246) Shigella flexneri 2a str. 2457T 1076973 NP_836242.1 CDS citX NC_004741.1 549283 549771 R 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase complement(549283..549771) Shigella flexneri 2a str. 2457T 1076974 NP_836243.1 CDS citF NC_004741.1 549775 551307 R residues 1 to 510 of 510 are 99.01 pct identical to residues 1 to 510 of 510 from Escherichia coli K-12 : B0615; citrate lyase subunit alpha complement(549775..551307) Shigella flexneri 2a str. 2457T 1078027 NP_836244.1 CDS citE NC_004741.1 551318 552226 R residues 1 to 302 of 302 are 95.36 pct identical to residues 6 to 307 of 307 from Escherichia coli K-12 : B0616; citrate lyase beta chain (acyl lyase subunit) complement(551318..552226) Shigella flexneri 2a str. 2457T 1076975 NP_836245.1 CDS citD NC_004741.1 552223 552519 R acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma complement(552223..552519) Shigella flexneri 2a str. 2457T 1076976 NP_836246.1 CDS citC NC_004741.1 552534 553679 R residues 1 to 381 of 381 are 99.47 pct identical to residues 1 to 381 of 381 from Escherichia coli K-12 : B0618; citrate lyase synthetase (citrate (pro-3S)-lyase ligase complement(552534..553679) Shigella flexneri 2a str. 2457T 1076978 NP_836247.1 CDS S0543 NC_004741.1 554059 554562 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(554059..554562) Shigella flexneri 2a str. 2457T 1076979 NP_836248.1 CDS S0545 NC_004741.1 554481 554756 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(554481..554756) Shigella flexneri 2a str. 2457T 1076980 NP_836249.1 CDS ybhA NC_004741.1 555625 556443 D YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase 555625..556443 Shigella flexneri 2a str. 2457T 1078907 NP_836250.1 CDS modC NC_004741.1 556444 557502 R Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein complement(556444..557502) Shigella flexneri 2a str. 2457T 1076981 NP_836251.1 CDS modB NC_004741.1 557505 558194 R part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease complement(557505..558194) Shigella flexneri 2a str. 2457T 1076982 NP_836252.1 CDS modA NC_004741.1 558194 558967 R with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein complement(558194..558967) Shigella flexneri 2a str. 2457T 1076983 NP_836253.1 CDS S0550 NC_004741.1 559134 559283 R residues 1 to 49 of 49 are 71.42 pct identical to residues 1 to 49 of 49 from Escherichia coli K-12 : B0762; hypothetical protein complement(559134..559283) Shigella flexneri 2a str. 2457T 1076984 NP_836254.1 CDS modE NC_004741.1 559412 560200 D represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 559412..560200 Shigella flexneri 2a str. 2457T 1076985 NP_836255.1 CDS modF NC_004741.1 560268 561740 D contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF 560268..561740 Shigella flexneri 2a str. 2457T 1076986 NP_836256.1 CDS galE NC_004741.1 562001 563017 D residues 1 to 338 of 338 are 99.11 pct identical to residues 1 to 338 of 338 from Escherichia coli K-12 : B0759; UDP-galactose-4-epimerase 562001..563017 Shigella flexneri 2a str. 2457T 1076987 NP_836257.1 CDS galT NC_004741.1 563027 564073 D catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 563027..564073 Shigella flexneri 2a str. 2457T 1076988 NP_836258.1 CDS galK NC_004741.1 564077 565225 D catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 564077..565225 Shigella flexneri 2a str. 2457T 1076989 NP_836259.1 CDS galM NC_004741.1 565219 566259 D catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 565219..566259 Shigella flexneri 2a str. 2457T 1076990 NP_836260.1 CDS gpmA NC_004741.1 566462 567214 D catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 566462..567214 Shigella flexneri 2a str. 2457T 1076992 NP_836261.1 CDS aroG NC_004741.1 567381 568433 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(567381..568433) Shigella flexneri 2a str. 2457T 1076993 NP_836262.1 CDS S0559 NC_004741.1 568749 569129 D residues 1 to 126 of 126 are 65.07 pct identical to residues 1 to 126 of 126 from Escherichia coli K-12 : B0753; homeobox protein 568749..569129 Shigella flexneri 2a str. 2457T 1076994 NP_836263.1 CDS ybgR NC_004741.1 569243 570184 D involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 569243..570184 Shigella flexneri 2a str. 2457T 1079579 NP_836264.1 CDS pnuC NC_004741.1 570181 570900 R residues 1 to 239 of 239 are 100.00 pct identical to residues 1 to 239 of 239 from Escherichia coli K-12 : B0751; required for NMN transport; PnuC protein complement(570181..570900) Shigella flexneri 2a str. 2457T 1076995 NP_836265.1 CDS nadA NC_004741.1 570938 571981 R 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase complement(570938..571981) Shigella flexneri 2a str. 2457T 1076997 NP_836266.1 CDS ybgF NC_004741.1 572965 573756 R periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF complement(572965..573756) Shigella flexneri 2a str. 2457T 1077006 NP_836267.1 CDS pal NC_004741.1 573766 574287 R residues 1 to 173 of 173 are 93.64 pct identical to residues 1 to 173 of 173 from Escherichia coli K-12 : B0741; peptidoglycan-associated outer membrane lipoprotein complement(573766..574287) Shigella flexneri 2a str. 2457T 1077007 NP_836268.1 CDS tolB NC_004741.1 574322 575614 R forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB complement(574322..575614) Shigella flexneri 2a str. 2457T 1076964 NP_836269.1 CDS tolA NC_004741.1 575747 576988 R inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA complement(575747..576988) Shigella flexneri 2a str. 2457T 1077008 NP_836270.1 CDS tolR NC_004741.1 577053 577481 R membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR complement(577053..577481) Shigella flexneri 2a str. 2457T 1077009 NP_836271.1 CDS tolQ NC_004741.1 577485 578177 R membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ complement(577485..578177) Shigella flexneri 2a str. 2457T 1077010 NP_836272.1 CDS ybgC NC_004741.1 578174 578578 R catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase YbgC complement(578174..578578) Shigella flexneri 2a str. 2457T 1077011 NP_836273.1 CDS ybgE NC_004741.1 578728 579021 R residues 1 to 93 of 97 are 100.00 pct identical to residues 1 to 93 of 97 from Escherichia coli K-12 : B0735; hypothetical protein complement(578728..579021) Shigella flexneri 2a str. 2457T 1077012 NP_836274.1 CDS cydB NC_004741.1 579149 580288 R residues 1 to 379 of 379 are 92.61 pct identical to residues 1 to 379 of 379 from Escherichia coli K-12 : B0734; cytochrome d terminal oxidase polypeptide subunit II complement(579149..580288) Shigella flexneri 2a str. 2457T 1080352 NP_836275.1 CDS cydA NC_004741.1 580304 581875 R residues 1 to 523 of 523 are 99.80 pct identical to residues 1 to 523 of 523 from Escherichia coli K-12 : B0733; cytochrome d terminal oxidase, polypeptide subunit I complement(580304..581875) Shigella flexneri 2a str. 2457T 1077013 NP_836276.1 CDS ybgG NC_004741.1 582720 585353 R residues 1 to 877 of 877 are 93.84 pct identical to residues 1 to 877 of 877 from Escherichia coli K-12 : B0732; alpha-mannosidase complement(582720..585353) Shigella flexneri 2a str. 2457T 1077014 NP_836277.1 CDS hrsA NC_004741.1 585371 587347 R involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; 2-O-a-mannosyl-D-glycerate specific PTS transporten components IIABC complement(585371..587347) Shigella flexneri 2a str. 2457T 1077015 NP_836278.1 CDS farR NC_004741.1 587457 588401 D regulates the succiny-lCoA synthetase operon; DNA-binding transcriptional repressor MngR 587457..588401 Shigella flexneri 2a str. 2457T 1077016 NP_836279.1 CDS sucD NC_004741.1 588283 589152 R Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha complement(588283..589152) Shigella flexneri 2a str. 2457T 1079055 NP_836280.1 CDS sucC NC_004741.1 589152 590318 R catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta complement(589152..590318) Shigella flexneri 2a str. 2457T 1077017 NP_836281.1 CDS sucB NC_004741.1 590412 591629 R component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase complement(590412..591629) Shigella flexneri 2a str. 2457T 1077019 NP_836282.1 CDS sucA NC_004741.1 591644 594445 R SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component complement(591644..594445) Shigella flexneri 2a str. 2457T 1077020 NP_836283.1 CDS S0585 NC_004741.1 594427 594687 R residues 1 to 86 of 86 are 100.00 pct identical to residues 1 to 86 of 86 from Escherichia coli K-12 : B0725; hypothetical protein complement(594427..594687) Shigella flexneri 2a str. 2457T 1077021 NP_836284.1 CDS sdhB NC_004741.1 594746 595462 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit complement(594746..595462) Shigella flexneri 2a str. 2457T 1076493 NP_836285.1 CDS sdhA NC_004741.1 595478 597244 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit complement(595478..597244) Shigella flexneri 2a str. 2457T 1079049 NP_836286.1 CDS sdhD NC_004741.1 597244 597591 R residues 1 to 94 of 115 are 100.00 pct identical to residues 1 to 94 of 115 from Escherichia coli K-12 : B0722; succinate dehydrogenase cytochrome b556 small membrane subunit complement(597244..597591) Shigella flexneri 2a str. 2457T 1077022 NP_836287.2 CDS sdhC NC_004741.1 597585 597974 R residues 6 to 134 of 134 are 99.22 pct identical to residues 1 to 129 of 129 from Escherichia coli K-12 : B0721; succinate dehydrogenase cytochrome b556 large membrane subunit complement(597585..597974) Shigella flexneri 2a str. 2457T 1077024 NP_836288.1 CDS gltA NC_004741.1 598683 599966 D type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 598683..599966 Shigella flexneri 2a str. 2457T 1079972 NP_836289.1 CDS ybgD NC_004741.1 600357 600923 D residues 1 to 188 of 188 are 76.06 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 : B0719; fimbrial-like protein 600357..600923 Shigella flexneri 2a str. 2457T 1077025 NP_836290.1 CDS ybgQ NC_004741.1 600974 603433 D residues 1 to 819 of 819 are 93.16 pct identical to residues 1 to 818 of 818 from Escherichia coli K-12 : B0718; outer membrane protein 600974..603433 Shigella flexneri 2a str. 2457T 1077026 NP_836291.1 CDS ybgP NC_004741.1 603448 604179 D residues 1 to 242 of 243 are 87.19 pct identical to residues 1 to 242 of 242 from Escherichia coli K-12 : B0717; chaperone 603448..604179 Shigella flexneri 2a str. 2457T 1077027 NP_836292.1 CDS abrB NC_004741.1 605359 606450 D residues 1 to 363 of 363 are 95.59 pct identical to residues 1 to 363 of 363 from Escherichia coli K-12 : B0715; transporter 605359..606450 Shigella flexneri 2a str. 2457T 1076462 NP_836293.1 CDS nei NC_004741.1 606447 607238 R 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII complement(606447..607238) Shigella flexneri 2a str. 2457T 1077029 NP_836294.1 CDS ybgL NC_004741.1 607274 608008 R residues 1 to 244 of 244 are 92.62 pct identical to residues 1 to 244 of 244 from Escherichia coli K-12 : B0713; LamB/YcsF family protein complement(607274..608008) Shigella flexneri 2a str. 2457T 1076835 NP_836295.1 CDS ybgJ NC_004741.1 608924 609580 R residues 1 to 218 of 218 are 99.08 pct identical to residues 1 to 218 of 218 from Escherichia coli K-12 : B0711; carboxylase complement(608924..609580) Shigella flexneri 2a str. 2457T 1077031 NP_836296.1 CDS ybgI NC_004741.1 609603 610346 R residues 1 to 247 of 247 are 94.73 pct identical to residues 1 to 247 of 247 from Escherichia coli K-12 : B0710; hydrolase-oxidase complement(609603..610346) Shigella flexneri 2a str. 2457T 1077032 NP_836297.1 CDS ybgH NC_004741.1 610617 612098 D residues 1 to 493 of 493 are 97.16 pct identical to residues 1 to 493 of 493 from Escherichia coli K-12 : B0709; transporter 610617..612098 Shigella flexneri 2a str. 2457T 1077033 NP_836298.1 CDS phrB NC_004741.1 612248 613666 R UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase complement(612248..613666) Shigella flexneri 2a str. 2457T 1077023 NP_836299.1 CDS ybgA NC_004741.1 613663 614172 R residues 1 to 169 of 169 are 98.81 pct identical to residues 1 to 169 of 169 from Escherichia coli K-12 : B0707; hypothetical protein complement(613663..614172) Shigella flexneri 2a str. 2457T 1077034 NP_836300.1 CDS S0604 NC_004741.1 614301 614588 D no significant similarities; hypothetical protein 614301..614588 Shigella flexneri 2a str. 2457T 1077035 NP_836301.1 CDS rhsE NC_004741.1 615026 618412 R residues 702 to 1008 of 1128 are 59.29 pct identical to residues 524 to 822 of 843 from GenPept : >emb|CAD08754.1| (AL627266) Rhs-family protein [Salmonella enterica subsp. enterica serovar Typhi]; Rhs-family protein complement(615026..618412) Shigella flexneri 2a str. 2457T 1077036 NP_836302.1 CDS S0606 NC_004741.1 619028 619531 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(619028..619531) Shigella flexneri 2a str. 2457T 1077045 NP_836303.1 CDS S0607 NC_004741.1 619450 619734 R residues 1 to 94 of 94 are 79.78 pct identical to residues 1 to 94 of 94 from GenPept : >gb|AAF70018.1|AF250878_179 (AF250878) IS1 transposase [Salmonella typhi]; IS1 orfA complement(619450..619734) Shigella flexneri 2a str. 2457T 1080996 NP_836304.1 CDS ybfA NC_004741.1 620220 620426 R residues 1 to 68 of 68 are 100.00 pct identical to residues 1 to 68 of 68 from Escherichia coli K-12 : B0699; hypothetical protein complement(620220..620426) Shigella flexneri 2a str. 2457T 1077037 NP_836305.1 CDS kdpA NC_004741.1 620828 622501 D catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 620828..622501 Shigella flexneri 2a str. 2457T 1077038 NP_836306.1 CDS kdpC NC_004741.1 624580 625152 D One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 624580..625152 Shigella flexneri 2a str. 2457T 1077040 NP_836307.1 CDS potE NC_004741.1 631391 632710 D catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 631391..632710 Shigella flexneri 2a str. 2457T 1078494 NP_836308.1 CDS pgm NC_004741.1 632766 634406 R catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase complement(632766..634406) Shigella flexneri 2a str. 2457T 1077044 NP_836309.1 CDS seqA NC_004741.1 634432 634977 R negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA complement(634432..634977) Shigella flexneri 2a str. 2457T 1077046 NP_836310.1 CDS ybfF NC_004741.1 635162 635926 D residues 1 to 254 of 254 are 98.81 pct identical to residues 1 to 254 of 254 from Escherichia coli K-12 : B0686; hypothetical protein 635162..635926 Shigella flexneri 2a str. 2457T 1077047 NP_836311.1 CDS ybfE NC_004741.1 635997 636359 D residues 1 to 120 of 120 are 85.00 pct identical to residues 1 to 120 of 120 from Escherichia coli K-12 : B0685; LexA regulated protein 635997..636359 Shigella flexneri 2a str. 2457T 1077048 NP_836312.1 CDS fldA NC_004741.1 636499 637029 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 636499..637029 Shigella flexneri 2a str. 2457T 1077053 NP_836313.1 CDS fur NC_004741.1 637318 637764 D negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 637318..637764 Shigella flexneri 2a str. 2457T 1077049 NP_836314.1 CDS ybfN NC_004741.1 637848 638174 R residues 1 to 108 of 108 are 98.14 pct identical to residues 1 to 108 of 108 from Escherichia coli K-12 : B0682; hypothetical protein complement(637848..638174) Shigella flexneri 2a str. 2457T 1077050 NP_836315.1 CDS ybfM NC_004741.1 638211 639617 R residues 1 to 468 of 468 are 99.14 pct identical to residues 1 to 468 of 468 from Escherichia coli K-12 : B0681; hypothetical protein complement(638211..639617) Shigella flexneri 2a str. 2457T 1077051 NP_836316.1 CDS glnS NC_004741.1 640196 641860 R catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase complement(640196..641860) Shigella flexneri 2a str. 2457T 1077052 NP_836317.1 CDS nagE NC_004741.1 642063 644009 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; N-acetyl glucosamine specific PTS system components IIABC complement(642063..644009) Shigella flexneri 2a str. 2457T 1077054 NP_836318.1 CDS nagB NC_004741.1 644342 645142 D catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 644342..645142 Shigella flexneri 2a str. 2457T 1077056 NP_836319.1 CDS nagA NC_004741.1 645202 646350 D catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 645202..646350 Shigella flexneri 2a str. 2457T 1077057 NP_836320.1 CDS nagC NC_004741.1 646359 647579 D residues 1 to 406 of 406 are 100.00 pct identical to residues 1 to 406 of 406 from Escherichia coli K-12 : B0676; transcriptional repressor of nag (N-acetylglucosamine) operon 646359..647579 Shigella flexneri 2a str. 2457T 1077058 NP_836321.1 CDS asnB NC_004741.1 648776 650440 D functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 648776..650440 Shigella flexneri 2a str. 2457T 1077060 NP_836322.1 CDS ubiF NC_004741.1 651676 652851 R catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase complement(651676..652851) Shigella flexneri 2a str. 2457T 1077070 NP_836323.1 CDS yleA NC_004741.1 652997 654421 D residues 1 to 474 of 474 are 99.78 pct identical to residues 1 to 474 of 474 from Escherichia coli K-12 : B0661; hypothetical protein 652997..654421 Shigella flexneri 2a str. 2457T 1077071 NP_836324.1 CDS ybeZ NC_004741.1 654535 655614 D residues 1 to 336 of 359 are 100.00 pct identical to residues 1 to 336 of 359 from Escherichia coli K-12 : B0660; ATP-binding protein in pho regulon 654535..655614 Shigella flexneri 2a str. 2457T 1077072 NP_836325.1 CDS ybeY NC_004741.1 655611 656078 D residues 1 to 155 of 155 are 88.38 pct identical to residues 1 to 155 of 155 from Escherichia coli K-12 : B0659; metalloprotease 655611..656078 Shigella flexneri 2a str. 2457T 1077074 NP_836326.1 CDS ybeX NC_004741.1 656168 657046 D residues 1 to 292 of 292 are 95.54 pct identical to residues 1 to 292 of 292 from Escherichia coli K-12 : B0658; transporter 656168..657046 Shigella flexneri 2a str. 2457T 1077075 NP_836327.1 CDS lnt NC_004741.1 657071 658609 D Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 657071..658609 Shigella flexneri 2a str. 2457T 1077076 NP_836328.1 CDS ybeJ NC_004741.1 659005 659913 D residues 1 to 302 of 302 are 89.73 pct identical to residues 1 to 302 of 302 from Escherichia coli K-12 : B0655; glutamate and aspartate transporter subunit 659005..659913 Shigella flexneri 2a str. 2457T 1079280 NP_836329.1 CDS gltJ NC_004741.1 660083 660823 D residues 1 to 246 of 246 are 99.18 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B0654; glutamate/aspartate transport system permease 660083..660823 Shigella flexneri 2a str. 2457T 1077077 NP_836330.1 CDS gltK NC_004741.1 660823 661497 D residues 1 to 224 of 224 are 99.55 pct identical to residues 1 to 224 of 224 from Escherichia coli K-12 : B0653; glutamate/aspartate transport system permease 660823..661497 Shigella flexneri 2a str. 2457T 1077078 NP_836331.1 CDS gltL NC_004741.1 661497 662222 D residues 1 to 241 of 241 are 94.60 pct identical to residues 1 to 241 of 241 from Escherichia coli K-12 : B0652; ATP-binding protein of glutamate/aspartate transport system 661497..662222 Shigella flexneri 2a str. 2457T 1077079 NP_836332.1 CDS rihA NC_004741.1 662340 663275 D Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 662340..663275 Shigella flexneri 2a str. 2457T 1077080 NP_836333.1 CDS ybeV NC_004741.1 665089 666540 R residues 1 to 483 of 483 are 92.13 pct identical to residues 1 to 483 of 483 from Escherichia coli K-12 : B0649; hypothetical protein complement(665089..666540) Shigella flexneri 2a str. 2457T 1077084 NP_836334.1 CDS ybeU NC_004741.1 666537 667244 R residues 1 to 235 of 235 are 96.59 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B0648; tRNA ligase complement(666537..667244) Shigella flexneri 2a str. 2457T 1077085 NP_836335.1 CDS ybeT NC_004741.1 667346 667900 D residues 1 to 184 of 184 are 97.28 pct identical to residues 1 to 184 of 184 from Escherichia coli K-12 : B0647; hypothetical protein 667346..667900 Shigella flexneri 2a str. 2457T 1077086 NP_836336.1 CDS ybeS NC_004741.1 667910 669337 R residues 1 to 475 of 475 are 93.68 pct identical to residues 1 to 475 of 475 from Escherichia coli K-12 : B0646; involved in polynucleotide modification; enzyme complement(667910..669337) Shigella flexneri 2a str. 2457T 1077088 NP_836337.1 CDS ybeR NC_004741.1 669334 670041 R residues 1 to 235 of 235 are 93.19 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B0645; hypothetical protein complement(669334..670041) Shigella flexneri 2a str. 2457T 1077089 NP_836338.1 CDS ybeQ NC_004741.1 670199 671182 D residues 1 to 327 of 327 are 96.63 pct identical to residues 1 to 327 of 327 from Escherichia coli K-12 : B0644; hypothetical protein 670199..671182 Shigella flexneri 2a str. 2457T 1077090 NP_836339.1 CDS ybeL NC_004741.1 671252 671734 R residues 1 to 160 of 160 are 97.50 pct identical to residues 1 to 160 of 160 from Escherichia coli K-12 : B0643; hypothetical protein complement(671252..671734) Shigella flexneri 2a str. 2457T 1077091 NP_836340.1 CDS leuS NC_004741.1 671969 674551 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 671969..674551 Shigella flexneri 2a str. 2457T 1080411 NP_836341.1 CDS rlpB NC_004741.1 674566 675147 D rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 674566..675147 Shigella flexneri 2a str. 2457T 1077092 NP_836342.1 CDS holA NC_004741.1 675147 676178 D required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 675147..676178 Shigella flexneri 2a str. 2457T 1077093 NP_836343.1 CDS nadD NC_004741.1 676180 676821 D transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 676180..676821 Shigella flexneri 2a str. 2457T 1077094 NP_836344.1 CDS phpB NC_004741.1 676845 677456 D residues 1 to 203 of 203 are 96.55 pct identical to residues 1 to 203 of 203 from Escherichia coli K-12 : B0638; alpha-ribazole phosphatase 676845..677456 Shigella flexneri 2a str. 2457T 1077087 NP_836345.1 CDS ybeB NC_004741.1 677824 678033 D residues 1 to 69 of 69 are 100.00 pct identical to residues 1 to 69 of 69 from Escherichia coli K-12 : B0637; hypothetical protein 677824..678033 Shigella flexneri 2a str. 2457T 1077073 NP_836346.1 CDS ybeA NC_004741.1 678037 678504 D SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 678037..678504 Shigella flexneri 2a str. 2457T 1077097 NP_836347.1 CDS mrdA NC_004741.1 678535 680436 D residues 1 to 633 of 633 are 99.68 pct identical to residues 1 to 633 of 633 from Escherichia coli K-12 : B0635; involved in cell elongation, ephase; penicillin-binding protein 2 678535..680436 Shigella flexneri 2a str. 2457T 1077098 NP_836348.1 CDS mrdB NC_004741.1 680439 681551 D residues 1 to 370 of 370 are 80.81 pct identical to residues 1 to 370 of 370 from Escherichia coli K-12 : B0634; sensitiveto radiation and drugs; cell wall shape-determining protein 680439..681551 Shigella flexneri 2a str. 2457T 1077099 NP_836349.1 CDS rlpA NC_004741.1 681562 682650 D residues 1 to 362 of 362 are 90.60 pct identical to residues 1 to 362 of 362 from Escherichia coli K-12 : B0633; rare lipoprotein A 681562..682650 Shigella flexneri 2a str. 2457T 1080410 NP_836350.1 CDS dacA NC_004741.1 682789 684000 D penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase 682789..684000 Shigella flexneri 2a str. 2457T 1077100 NP_836351.1 CDS ybeD NC_004741.1 684111 684374 D residues 1 to 87 of 87 are 100.00 pct identical to residues 1 to 87 of 87 from Escherichia coli K-12 : B0631; hypothetical protein 684111..684374 Shigella flexneri 2a str. 2457T 1078112 NP_836352.2 CDS lipB NC_004741.1 684475 685116 D lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse; lipoate-protein ligase B; transfers lipoate to apolipoproteins; involved in lipoate metabolism; lipoyltransferase 684475..685116 Shigella flexneri 2a str. 2457T 1077101 NP_836353.1 CDS ybeF NC_004741.1 685528 686328 D residues 1 to 266 of 266 are 98.87 pct identical to residues 1 to 266 of 266 from Escherichia coli K-12 : B0629; DNA-binding transcriptional regulator 685528..686328 Shigella flexneri 2a str. 2457T 1077102 NP_836354.1 CDS lipA NC_004741.1 686537 687502 D catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 686537..687502 Shigella flexneri 2a str. 2457T 1077103 NP_836355.1 CDS tatE NC_004741.1 687603 687806 R TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase E complement(687603..687806) Shigella flexneri 2a str. 2457T 1077104 NP_836356.1 CDS ybeM NC_004741.1 687935 688498 R residues 1 to 187 of 187 are 94.11 pct identical to residues 1 to 187 of 187 from Escherichia coli K-12 : B0626; amidase complement(687935..688498) Shigella flexneri 2a str. 2457T 1077105 NP_836357.1 CDS ccrB NC_004741.1 688816 689199 D may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 688816..689199 Shigella flexneri 2a str. 2457T 1077107 NP_836358.1 CDS cspE NC_004741.1 689253 689462 R member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE complement(689253..689462) Shigella flexneri 2a str. 2457T 1078238 NP_836359.1 CDS pagP NC_004741.1 689637 690197 R catalyzes the transfer of palmitate to lipid A; palmitoyl transferase complement(689637..690197) Shigella flexneri 2a str. 2457T 1077108 NP_836360.1 CDS dcuC NC_004741.1 690786 692171 D responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 690786..692171 Shigella flexneri 2a str. 2457T 1077109 NP_836361.1 CDS S0684 NC_004741.1 692891 693400 R residues 20 to 169 of 169 are 35.08 pct identical to residues 4 to 174 of 174 from GenPept : >gb|AAF01132.1|AF083977_53 (AF083977) c-repressor [Enterobacteria phage Mu]; repressor protein complement(692891..693400) Shigella flexneri 2a str. 2457T 1077113 NP_836362.1 CDS S0685 NC_004741.1 693963 695417 D residues 1 to 484 of 484 are 96.90 pct identical to residues 62 to 545 of 663 from GenPept : >gb|AAF01083.1|AF083977_2 (AF083977) A [Enterobacteria phage Mu]; phage transposase 693963..695417 Shigella flexneri 2a str. 2457T 1077114 NP_836363.1 CDS S0686 NC_004741.1 695479 695781 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 695479..695781 Shigella flexneri 2a str. 2457T 1077115 NP_836364.1 CDS S0687 NC_004741.1 695922 696635 D residues 1 to 237 of 237 are 99.57 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72454.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 695922..696635 Shigella flexneri 2a str. 2457T 1080944 NP_836365.1 CDS S0688 NC_004741.1 696632 696877 R residues 1 to 50 of 81 are 68.62 pct identical to residues 1 to 51 of 122 from GenPept : >emb|CAD05577.1| (AL627272) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(696632..696877) Shigella flexneri 2a str. 2457T 1080945 NP_836366.1 CDS S0689 NC_004741.1 696919 697860 R residues 1 to 313 of 313 are 97.76 pct identical to residues 1 to 313 of 313 from GenPept : >emb|CAD05445.1| (AL627268) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein complement(696919..697860) Shigella flexneri 2a str. 2457T 1077116 NP_836367.1 CDS S0690 NC_004741.1 697872 697973 R residues 1 to 33 of 33 are 100.00 pct identical to residues 136 to 168 of 168 from GenPept : >emb|CAD05444.1| (AL627268) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(697872..697973) Shigella flexneri 2a str. 2457T 1077117 NP_836368.1 CDS S0691 NC_004741.1 698005 698361 R residues 1 to 116 of 118 are 100.00 pct identical to residues 1 to 116 of 168 from GenPept : >emb|CAD05444.1| (AL627268) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein complement(698005..698361) Shigella flexneri 2a str. 2457T 1077118 NP_836369.1 CDS S0692 NC_004741.1 698365 699585 R residues 1 to 406 of 406 are 89.90 pct identical to residues 1 to 406 of 406 from GenPept : >emb|CAD05443.1| (AL627268) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein complement(698365..699585) Shigella flexneri 2a str. 2457T 1077119 NP_836370.1 CDS S0693 NC_004741.1 699589 700047 R residues 2 to 141 of 152 are 86.42 pct identical to residues 29 to 168 of 176 from GenPept : >emb|CAD05581.1| (AL627272) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein complement(699589..700047) Shigella flexneri 2a str. 2457T 1077120 NP_836371.1 CDS S0694 NC_004741.1 700223 701689 R residues 1 to 488 of 488 are 96.72 pct identical to residues 1 to 488 of 488 from GenPept : >emb|CAD05582.1| (AL627272) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein complement(700223..701689) Shigella flexneri 2a str. 2457T 1077121 NP_836372.1 CDS S0695 NC_004741.1 701689 701922 R residues 1 to 77 of 77 are 81.81 pct identical to residues 391 to 467 of 467 from GenPept : >emb|CAD05583.1| (AL627272) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(701689..701922) Shigella flexneri 2a str. 2457T 1077122 NP_836373.1 CDS S0696 NC_004741.1 701910 702449 R residues 10 to 167 of 179 are 96.20 pct identical to residues 222 to 379 of 467 from GenPept : >emb|CAD05583.1| (AL627272) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein complement(701910..702449) Shigella flexneri 2a str. 2457T 1077123 NP_836374.2 CDS S0697 NC_004741.1 702434 703339 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(702434..703339) Shigella flexneri 2a str. 2457T 1077124 NP_836375.2 CDS S0698 NC_004741.1 703297 703662 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(703297..703662) Shigella flexneri 2a str. 2457T 1077125 NP_836376.1 CDS S0699 NC_004741.1 703738 704361 R residues 2 to 203 of 207 are 99.50 pct identical to residues 22 to 223 of 467 from GenPept : >emb|CAD05583.1| (AL627272) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein complement(703738..704361) Shigella flexneri 2a str. 2457T 1077126 NP_836377.1 CDS S0700 NC_004741.1 704372 705136 R residues 1 to 249 of 254 are 97.18 pct identical to residues 1 to 249 of 249 from GenPept : >emb|CAD05584.1| (AL627272) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein complement(704372..705136) Shigella flexneri 2a str. 2457T 1077129 NP_836378.1 CDS S0701 NC_004741.1 705206 705832 R residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB complement(705206..705832) Shigella flexneri 2a str. 2457T 1077128 NP_836379.1 CDS S0702 NC_004741.1 705829 706029 R partial; IS911 orfB complement(705829..706029) Shigella flexneri 2a str. 2457T 1077127 NP_836380.1 CDS S0703 NC_004741.1 706072 706374 R residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA complement(706072..706374) Shigella flexneri 2a str. 2457T 1077130 NP_836381.1 CDS S0704 NC_004741.1 706519 706692 D residues 1 to 55 of 57 are 90.90 pct identical to residues 100 to 154 of 155 from GenPept : >gb|AAG55117.1|AE005256_8 (AE005256) endopeptidase Rz of prophage CP-933K [Escherichia coli O157:H7 EDL933]; partial; hypothetical protein 706519..706692 Shigella flexneri 2a str. 2457T 1077131 NP_836382.1 CDS S0705 NC_004741.1 707502 707804 D residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 707502..707804 Shigella flexneri 2a str. 2457T 1077587 NP_836383.1 CDS S0706 NC_004741.1 707847 708047 D partial; IS911 orfB 707847..708047 Shigella flexneri 2a str. 2457T 1077132 NP_836384.1 CDS S0707 NC_004741.1 708044 708202 D residues 1 to 43 of 52 are 97.67 pct identical to residues 72 to 114 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB 708044..708202 Shigella flexneri 2a str. 2457T 1077083 NP_836385.1 CDS S0708 NC_004741.1 708293 708667 D residues 1 to 124 of 124 are 100.00 pct identical to residues 156 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB 708293..708667 Shigella flexneri 2a str. 2457T 1077133 NP_836386.1 CDS S0709 NC_004741.1 708696 709118 D residues 1 to 140 of 140 are 88.57 pct identical to residues 49 to 188 of 188 from GenPept : >gb|AAG56172.1|AE005347_4 (AE005347) unknown protein encoded within prophage CP-933O [Escherichia coli O157:H7 EDL933]; bacteriophage protein 708696..709118 Shigella flexneri 2a str. 2457T 1077134 NP_836387.1 CDS ybcR NC_004741.1 710297 710389 D residues 1 to 30 of 30 are 89.99 pct identical to residues 1 to 30 of 71 from GenPept : >gb|AAA32349.1| (M65239) S [Bacteriophage 21]; hypothetical protein 710297..710389 Shigella flexneri 2a str. 2457T 1077139 NP_836388.1 CDS S0715 NC_004741.1 710430 711116 R residues 1 to 228 of 228 are 87.34 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB complement(710430..711116) Shigella flexneri 2a str. 2457T 1077140 NP_836389.1 CDS S0716 NC_004741.1 711257 711559 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA complement(711257..711559) Shigella flexneri 2a str. 2457T 1077141 NP_836390.1 CDS S0718 NC_004741.1 711835 713694 D residues 368 to 567 of 619 are 29.32 pct identical to residues 690 to 895 of 916 from GenPept : >gb|AAF10830.1|AE001973_3 (AE001973) SNF2/Rad54 helicase-related protein [Deinococcus radiodurans]; bacteriophage protein 711835..713694 Shigella flexneri 2a str. 2457T 1077142 NP_836391.1 CDS S0719 NC_004741.1 713669 714295 R residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB complement(713669..714295) Shigella flexneri 2a str. 2457T 1077143 NP_836392.1 CDS S0720 NC_004741.1 714292 714492 R partial; IS911 orfB complement(714292..714492) Shigella flexneri 2a str. 2457T 1077144 NP_836393.1 CDS S0721 NC_004741.1 714535 714837 R residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA complement(714535..714837) Shigella flexneri 2a str. 2457T 1078460 NP_836394.1 CDS S0722 NC_004741.1 714930 715808 D residues 41 to 292 of 292 are 95.63 pct identical to residues 1 to 252 of 252 from GenPept : >emb|CAC83536.1| (AJ298298) replication protein DnaC [Bacteriophage P27]; replication protein DnaC 714930..715808 Shigella flexneri 2a str. 2457T 1077145 NP_836395.1 CDS S0723 NC_004741.1 715805 717196 D residues 1 to 463 of 463 are 90.49 pct identical to residues 1 to 463 of 463 from GenPept : >emb|CAC83537.1| (AJ298298) helicase [Bacteriophage P27]; helicase 715805..717196 Shigella flexneri 2a str. 2457T 1077146 NP_836396.1 CDS S0724 NC_004741.1 717193 717450 D residues 6 to 85 of 85 are 93.75 pct identical to residues 1 to 80 of 80 from GenPept : >emb|CAC83538.1| (AJ298298) hypothetical protein [Bacteriophage P27]; bacteriophage protein 717193..717450 Shigella flexneri 2a str. 2457T 1077147 NP_836397.1 CDS S0725 NC_004741.1 717545 717745 D residues 1 to 66 of 66 are 63.63 pct identical to residues 1 to 64 of 64 from GenPept : >gb|AAD04654.1| (AF034975) nin orf-59 [Bacteriophage H-19B]; homologous to ninH gene; bacteriophage protein 717545..717745 Shigella flexneri 2a str. 2457T 1077148 NP_836398.1 CDS ybcQ NC_004741.1 717738 718118 D residues 1 to 124 of 126 are 77.41 pct identical to residues 1 to 124 of 144 from GenPept : >gb|AAD04655.1| (AF034975) Q protein [Bacteriophage H-19B]; Q protein 717738..718118 Shigella flexneri 2a str. 2457T 1077149 NP_836399.1 CDS S0731 NC_004741.1 718921 719136 D residues 1 to 71 of 71 are 74.64 pct identical to residues 1 to 71 of 71 from GenPept : >gb|AAA32349.1| (M65239) S [Bacteriophage 21]; S protein 718921..719136 Shigella flexneri 2a str. 2457T 1080348 NP_836400.1 CDS S0732 NC_004741.1 719140 719769 D no significant similarities; hypothetical protein 719140..719769 Shigella flexneri 2a str. 2457T 1077154 NP_836401.1 CDS S0733 NC_004741.1 719835 720368 D residues 1 to 177 of 177 are 83.61 pct identical to residues 1 to 177 of 177 from GenPept : >gb|AAG55897.1|AE005323_13 (AE005323) endolysin of prophage CP-933N [Escherichia coli O157:H7 EDL933]; endolysin R of prophage CP-933V 719835..720368 Shigella flexneri 2a str. 2457T 1077155 NP_836402.1 CDS S0734 NC_004741.1 720365 720769 D residues 1 to 134 of 134 are 96.26 pct identical to residues 1 to 134 of 155 from GenPept : >gb|AAK28885.1|AF335538_37 (AF335538) endopeptidase [Bacteriophage HK620]; endopeptidase 720365..720769 Shigella flexneri 2a str. 2457T 1077156 NP_836403.1 CDS S0735 NC_004741.1 720831 721133 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 720831..721133 Shigella flexneri 2a str. 2457T 1077157 NP_836404.1 CDS S0736 NC_004741.1 721274 721987 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 721274..721987 Shigella flexneri 2a str. 2457T 1077159 NP_836405.1 CDS S0737 NC_004741.1 722310 724220 D residues 1 to 625 of 636 are 91.20 pct identical to residues 13 to 636 of 654 from GenPept : >gb|AAG56410.1|AE005368_16 (AE005368) DNA packaging protein of prophage CP-933R; terminase large subunit [Escherichia coli O157:H7 EDL933]; DNA packaging protein of prophage CP-933R; terminase large subunit 722310..724220 Shigella flexneri 2a str. 2457T 1077160 NP_836406.1 CDS S0738 NC_004741.1 724221 724424 D residues 1 to 67 of 67 are 79.41 pct identical to residues 1 to 68 of 68 from GenPept : >gb|AAA32341.1| (M81255) head completion protein gp3 [Bacteriophage 21]; head completion protein gp3 724221..724424 Shigella flexneri 2a str. 2457T 1077161 NP_836407.1 CDS S0739 NC_004741.1 724421 725476 D residues 1 to 331 of 351 are 94.25 pct identical to residues 1 to 331 of 530 from GenPept : >gb|AAA32342.1| (M81255) head-tail preconnector gp5 [Bacteriophage 21]; head-tail preconnector gp5 724421..725476 Shigella flexneri 2a str. 2457T 1077162 NP_836408.1 CDS S0740 NC_004741.1 725391 726014 D residues 2 to 193 of 207 are 93.75 pct identical to residues 325 to 516 of 530 from GenPept : >gb|AAA32342.1| (M81255) head-tail preconnector gp5 [Bacteriophage 21]; head-tail preconnector gp5 725391..726014 Shigella flexneri 2a str. 2457T 1077702 NP_836409.1 CDS S0741 NC_004741.1 726004 727509 D residues 1 to 501 of 501 are 88.62 pct identical to residues 1 to 501 of 501 from GenPept : >gb|AAA32343.1| (M81255) head-tail preconnector gp5 [Bacteriophage 21]; head-tail preconnector gp5 726004..727509 Shigella flexneri 2a str. 2457T 1077163 NP_836410.1 CDS S0742 NC_004741.1 727546 727893 D residues 1 to 115 of 115 are 93.04 pct identical to residues 1 to 115 of 115 from GenPept : >gb|AAA32345.1| (M81255) capsid protein small subunit [Bacteriophage 21]; capsid protein small subunit 727546..727893 Shigella flexneri 2a str. 2457T 1077164 NP_836411.1 CDS S0743 NC_004741.1 727951 728979 D residues 1 to 342 of 342 are 90.35 pct identical to residues 1 to 342 of 342 from GenPept : >gb|AAA32346.1| (M81255) major capsid protein [Bacteriophage 21]; major capsid protein 727951..728979 Shigella flexneri 2a str. 2457T 1077165 NP_836412.1 CDS S0744 NC_004741.1 729031 729417 D residues 3 to 128 of 128 are 37.40 pct identical to residues 2 to 132 of 132 from GenPept : >gb|AAA96541.1| (J02459) Fi (DNA packaging;117) [bacteriophage lambda]; DNA-packaging protein 729031..729417 Shigella flexneri 2a str. 2457T 1077166 NP_836413.1 CDS S0745 NC_004741.1 729429 729806 D residues 1 to 117 of 125 are 57.26 pct identical to residues 1 to 117 of 117 from GenPept : >gb|AAA96542.1| (J02459) Fii (head-tail joining;117) [bacteriophage lambda]; tail attachment protein 729429..729806 Shigella flexneri 2a str. 2457T 1077167 NP_836414.1 CDS S0746 NC_004741.1 729793 730377 D residues 1 to 194 of 194 are 84.53 pct identical to residues 1 to 192 of 192 from GenPept : >gb|AAG55126.1|AE005257_5 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail component of prophage CP-933K 729793..730377 Shigella flexneri 2a str. 2457T 1077168 NP_836415.1 CDS S0747 NC_004741.1 730374 730775 D residues 1 to 133 of 133 are 96.99 pct identical to residues 1 to 133 of 133 from GenPept : >gb|AAG55127.1|AE005257_6 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail component of prophage CP-933K 730374..730775 Shigella flexneri 2a str. 2457T 1077169 NP_836416.1 CDS S0748 NC_004741.1 730786 731526 D residues 1 to 245 of 246 are 82.85 pct identical to residues 3 to 247 of 249 from GenPept : >gb|AAG55128.1|AE005257_7 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail component of prophage CP-933K 730786..731526 Shigella flexneri 2a str. 2457T 1077170 NP_836417.1 CDS S0749 NC_004741.1 731585 731971 D residues 1 to 128 of 128 are 92.18 pct identical to residues 5 to 132 of 132 from GenPept : >gb|AAG55129.1|AE005257_8 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail component of prophage CP-933K 731585..731971 Shigella flexneri 2a str. 2457T 1077171 NP_836418.1 CDS S0750 NC_004741.1 732034 732309 D residues 1 to 91 of 91 are 98.90 pct identical to residues 15 to 105 of 105 from GenPept : >gb|AAG55130.1|AE005257_9 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail component of prophage CP-933K 732034..732309 Shigella flexneri 2a str. 2457T 1077172 NP_836419.1 CDS S0751 NC_004741.1 732281 735322 D residues 1 to 1013 of 1013 are 78.64 pct identical to residues 1 to 1021 of 1021 from GenPept : >dbj|BAB34260.1| (AP002553) tail length tape measure protein precursor [Escherichia coli O157:H7]; tail length tape measure protein precursor 732281..735322 Shigella flexneri 2a str. 2457T 1077173 NP_836420.1 CDS S0752 NC_004741.1 735322 735651 D residues 1 to 108 of 109 are 97.22 pct identical to residues 1 to 108 of 109 from GenPept : >dbj|BAB34261.1| (AP002553) minor tail protein [Escherichia coli O157:H7]; minor tail protein 735322..735651 Shigella flexneri 2a str. 2457T 1080995 NP_836421.1 CDS S0753 NC_004741.1 735651 736349 D residues 1 to 232 of 232 are 90.51 pct identical to residues 1 to 232 of 232 from GenPept : >dbj|BAB35068.1| (AP002555) minor tail protein [Escherichia coli O157:H7]; minor tail protein 735651..736349 Shigella flexneri 2a str. 2457T 1077174 NP_836422.1 CDS S0754 NC_004741.1 736498 737097 D residues 1 to 199 of 199 are 96.98 pct identical to residues 26 to 224 of 224 from GenPept : >gb|AAG55134.1|AE005257_13 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail assembly protein 736498..737097 Shigella flexneri 2a str. 2457T 1080350 NP_836423.1 CDS S0755 NC_004741.1 737094 737636 D residues 1 to 180 of 180 are 85.71 pct identical to residues 34 to 215 of 215 from GenPept : >gb|AAG55135.1|AE005257_14 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail component 737094..737636 Shigella flexneri 2a str. 2457T 1077175 NP_836424.1 CDS S0756 NC_004741.1 737697 741176 D residues 1 to 1159 of 1159 are 85.13 pct identical to residues 1 to 1132 of 1132 from GenPept : >dbj|BAB35071.1| (AP002555) host specificity protein [Escherichia coli O157:H7]; host specificity protein 737697..741176 Shigella flexneri 2a str. 2457T 1077176 NP_836425.1 CDS S0757 NC_004741.1 741244 741843 D residues 1 to 199 of 199 are 93.46 pct identical to residues 1 to 199 of 199 from GenPept : >dbj|BAB35072.1| (AP002555) membrane protein precursor [Escherichia coli O157:H7]; membrane protein precursor 741244..741843 Shigella flexneri 2a str. 2457T 1077177 NP_836426.1 CDS S0758 NC_004741.1 741907 742968 D residues 1 to 291 of 353 are 39.11 pct identical to residues 1 to 294 of 490 from GenPept : >emb|CAC83574.1| (AJ298298) tail fiber protein [Bacteriophage P27]; tail component encoded by cryptic prophage CP-933M 741907..742968 Shigella flexneri 2a str. 2457T 1077178 NP_836427.1 CDS S0759 NC_004741.1 743269 743892 D residues 21 to 207 of 207 are 68.44 pct identical to residues 2 to 188 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; tail component of prophage CP-933K 743269..743892 Shigella flexneri 2a str. 2457T 1077179 NP_836428.1 CDS S0763 NC_004741.1 745944 746123 D no significant similarities; hypothetical protein 745944..746123 Shigella flexneri 2a str. 2457T 1077181 NP_836429.1 CDS ybhB NC_004741.1 746417 746893 R YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein complement(746417..746893) Shigella flexneri 2a str. 2457T 1077182 NP_836430.1 CDS bioA NC_004741.1 746952 748241 R catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase complement(746952..748241) Shigella flexneri 2a str. 2457T 1077235 NP_836431.1 CDS bioB NC_004741.1 748328 749368 D residues 1 to 346 of 346 are 99.42 pct identical to residues 1 to 346 of 346 from Escherichia coli K-12 : B0775; biotin synthase 748328..749368 Shigella flexneri 2a str. 2457T 1077183 NP_836432.1 CDS bioF NC_004741.1 749365 750519 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 749365..750519 Shigella flexneri 2a str. 2457T 1077184 NP_836433.1 CDS bioC NC_004741.1 750506 751261 D methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 750506..751261 Shigella flexneri 2a str. 2457T 1077185 NP_836434.1 CDS bioD NC_004741.1 751254 751931 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 751254..751931 Shigella flexneri 2a str. 2457T 1077187 NP_836435.1 CDS uvrB NC_004741.1 752510 754531 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 752510..754531 Shigella flexneri 2a str. 2457T 1077188 NP_836436.1 CDS ybhK NC_004741.1 754723 755631 R residues 1 to 302 of 302 are 91.39 pct identical to residues 1 to 302 of 302 from Escherichia coli K-12 : B0780; structural protein complement(754723..755631) Shigella flexneri 2a str. 2457T 1080351 NP_836437.1 CDS moaA NC_004741.1 756028 757017 D together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 756028..757017 Shigella flexneri 2a str. 2457T 1077189 NP_836438.1 CDS moaB NC_004741.1 757039 757551 D residues 1 to 170 of 170 are 99.41 pct identical to residues 1 to 170 of 170 from Escherichia coli K-12 : B0782; molybdopterin biosynthesis protein B 757039..757551 Shigella flexneri 2a str. 2457T 1077190 NP_836439.1 CDS moaC NC_004741.1 757554 758039 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein C 757554..758039 Shigella flexneri 2a str. 2457T 1077192 NP_836440.1 CDS moaD NC_004741.1 758032 758277 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 758032..758277 Shigella flexneri 2a str. 2457T 1077193 NP_836441.1 CDS moaE NC_004741.1 758279 758731 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase large subunit 758279..758731 Shigella flexneri 2a str. 2457T 1077194 NP_836442.1 CDS ybhL NC_004741.1 758868 759572 D residues 1 to 234 of 234 are 93.16 pct identical to residues 1 to 234 of 234 from Escherichia coli K-12 : B0786; hypothetical protein 758868..759572 Shigella flexneri 2a str. 2457T 1077195 NP_836443.1 CDS ybhM NC_004741.1 759777 760490 D residues 1 to 237 of 237 are 80.16 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B0787; hypothetical protein 759777..760490 Shigella flexneri 2a str. 2457T 1077196 NP_836444.1 CDS ybhN NC_004741.1 760526 761482 R residues 1 to 318 of 318 are 78.30 pct identical to residues 1 to 318 of 318 from Escherichia coli K-12 : B0788; hypothetical protein complement(760526..761482) Shigella flexneri 2a str. 2457T 1077197 NP_836445.1 CDS ybhO NC_004741.1 761482 762723 R residues 1 to 413 of 413 are 91.76 pct identical to residues 1 to 413 of 413 from Escherichia coli K-12 : B0789; cardiolipin synthase 2 complement(761482..762723) Shigella flexneri 2a str. 2457T 1077198 NP_836446.1 CDS ybhP NC_004741.1 762720 763481 R residues 1 to 253 of 253 are 100.00 pct identical to residues 1 to 253 of 253 from Escherichia coli K-12 : B0790; hypothetical protein complement(762720..763481) Shigella flexneri 2a str. 2457T 1077199 NP_836447.1 CDS ybhQ NC_004741.1 763614 764024 D residues 1 to 136 of 136 are 83.08 pct identical to residues 1 to 136 of 136 from Escherichia coli K-12 : B0791; hypothetical protein 763614..764024 Shigella flexneri 2a str. 2457T 1077201 NP_836448.1 CDS ybhR NC_004741.1 763986 765092 R residues 1 to 368 of 368 are 96.73 pct identical to residues 1 to 368 of 368 from Escherichia coli K-12 : B0792; hypothetical protein complement(763986..765092) Shigella flexneri 2a str. 2457T 1077202 NP_836449.1 CDS ybhS NC_004741.1 765103 766236 R residues 1 to 377 of 377 are 92.83 pct identical to residues 1 to 377 of 377 from Escherichia coli K-12 : B0793; hypothetical protein complement(765103..766236) Shigella flexneri 2a str. 2457T 1077191 NP_836450.1 CDS ybhF NC_004741.1 766229 767980 R residues 1 to 583 of 583 are 99.82 pct identical to residues 1 to 583 of 583 from Escherichia coli K-12 : B0794; ATP-binding component of a transport system complement(766229..767980) Shigella flexneri 2a str. 2457T 1077203 NP_836451.1 CDS S0786 NC_004741.1 767958 768956 R residues 1 to 332 of 332 are 82.53 pct identical to residues 1 to 332 of 332 from Escherichia coli K-12 : B0795; hypothetical protein complement(767958..768956) Shigella flexneri 2a str. 2457T 1077204 NP_836452.1 CDS ybiH NC_004741.1 768956 769639 R residues 1 to 227 of 227 are 88.98 pct identical to residues 1 to 227 of 227 from Escherichia coli K-12 : B0796; DNA-binding transcriptional regulator complement(768956..769639) Shigella flexneri 2a str. 2457T 1077205 NP_836453.1 CDS rhlE NC_004741.1 769856 771076 D this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 769856..771076 Shigella flexneri 2a str. 2457T 1077206 NP_836454.1 CDS ybiA NC_004741.1 771250 771732 R residues 1 to 160 of 160 are 96.87 pct identical to residues 1 to 160 of 160 from Escherichia coli K-12 : B0798; hypothetical protein complement(771250..771732) Shigella flexneri 2a str. 2457T 1077207 NP_836455.1 CDS dinG NC_004741.1 771852 774002 D helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 771852..774002 Shigella flexneri 2a str. 2457T 1077208 NP_836456.1 CDS ybiB NC_004741.1 774030 774992 D residues 1 to 320 of 320 are 98.43 pct identical to residues 1 to 320 of 320 from Escherichia coli K-12 : B0800; glycosyl transferase family protein 774030..774992 Shigella flexneri 2a str. 2457T 1077209 NP_836457.1 CDS ybiC NC_004741.1 775133 776218 D residues 1 to 361 of 361 are 98.89 pct identical to residues 1 to 361 of 361 from Escherichia coli K-12 : B0801; hypothetical protein 775133..776218 Shigella flexneri 2a str. 2457T 1077210 NP_836458.1 CDS ybiJ NC_004741.1 776447 776707 R residues 1 to 86 of 86 are 84.88 pct identical to residues 1 to 86 of 86 from Escherichia coli K-12 : B0802; hypothetical protein complement(776447..776707) Shigella flexneri 2a str. 2457T 1077211 NP_836459.1 CDS ybiI NC_004741.1 776972 777238 R residues 1 to 88 of 88 are 96.59 pct identical to residues 1 to 88 of 88 from Escherichia coli K-12 : B0803; hypothetical protein complement(776972..777238) Shigella flexneri 2a str. 2457T 1077212 NP_836460.2 CDS ybiX NC_004741.1 777312 777989 R residues 1 to 237 of 237 are 93.24 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B0804; hydroxylase complement(777312..777989) Shigella flexneri 2a str. 2457T 1077213 NP_836461.1 CDS S0797 NC_004741.1 780105 781433 D residues 1 to 442 of 442 are 99.54 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 780105..781433 Shigella flexneri 2a str. 2457T 1077214 NP_836462.1 CDS ybiM NC_004741.1 782016 782420 R residues 1 to 134 of 134 are 98.50 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B0806; hypothetical protein complement(782016..782420) Shigella flexneri 2a str. 2457T 1077215 NP_836463.1 CDS ybiN NC_004741.1 782471 783478 D residues 2 to 336 of 336 are 90.74 pct identical to residues 1 to 335 of 335 from Escherichia coli K-12 : B0807; SAM-dependent methyltransferase 782471..783478 Shigella flexneri 2a str. 2457T 1077216 NP_836464.1 CDS glnQ NC_004741.1 785960 786682 R similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein complement(785960..786682) Shigella flexneri 2a str. 2457T 1077218 NP_836465.1 CDS glnP NC_004741.1 786679 787338 R similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease complement(786679..787338) Shigella flexneri 2a str. 2457T 1077219 NP_836466.1 CDS glnH NC_004741.1 787477 788223 R similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein complement(787477..788223) Shigella flexneri 2a str. 2457T 1077220 NP_836467.1 CDS dps NC_004741.1 788627 789130 R binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps complement(788627..789130) Shigella flexneri 2a str. 2457T 1077186 NP_836468.1 CDS ybiF NC_004741.1 789429 790316 R residues 1 to 295 of 295 are 91.52 pct identical to residues 1 to 295 of 295 from Escherichia coli K-12 : B0813; threonine and homoserine efflux system complement(789429..790316) Shigella flexneri 2a str. 2457T 1077200 NP_836469.1 CDS ompX NC_004741.1 790669 791184 D OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 790669..791184 Shigella flexneri 2a str. 2457T 1077222 NP_836470.1 CDS ybiP NC_004741.1 791232 792815 R residues 1 to 527 of 527 are 97.72 pct identical to residues 1 to 527 of 527 from Escherichia coli K-12 : B0815; enzyme complement(791232..792815) Shigella flexneri 2a str. 2457T 1077223 NP_836471.1 CDS S0810 NC_004741.1 793401 793868 D Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 793401..793868 Shigella flexneri 2a str. 2457T 1077225 NP_836472.1 CDS ybiR NC_004741.1 793865 794983 D residues 1 to 371 of 372 are 87.60 pct identical to residues 1 to 371 of 372 from Escherichia coli K-12 : B0818; hypothetical protein 793865..794983 Shigella flexneri 2a str. 2457T 1077227 NP_836473.1 CDS ybiS NC_004741.1 795042 795962 R residues 1 to 306 of 306 are 99.67 pct identical to residues 1 to 306 of 306 from Escherichia coli K-12 : B0819; hypothetical protein complement(795042..795962) Shigella flexneri 2a str. 2457T 1077228 NP_836474.1 CDS ybiT NC_004741.1 796181 797773 D residues 1 to 530 of 530 are 99.81 pct identical to residues 1 to 530 of 530 from Escherichia coli K-12 : B0820; ATP-binding component of a transport system 796181..797773 Shigella flexneri 2a str. 2457T 1077243 NP_836475.1 CDS ybiU NC_004741.1 798014 799279 R residues 1 to 421 of 421 are 99.04 pct identical to residues 1 to 421 of 421 from Escherichia coli K-12 : B0821; hypothetical protein complement(798014..799279) Shigella flexneri 2a str. 2457T 1077229 NP_836476.1 CDS S0815 NC_004741.1 799431 800246 R residues 1 to 271 of 271 are 99.63 pct identical to residues 1 to 271 of 271 from Escherichia coli K-12 : B0822; hypothetical protein complement(799431..800246) Shigella flexneri 2a str. 2457T 1077230 NP_836477.1 CDS ybiW NC_004741.1 800392 802824 R residues 1 to 810 of 810 are 93.20 pct identical to residues 1 to 810 of 810 from Escherichia coli K-12 : B0823; formate acetyltransferase complement(800392..802824) Shigella flexneri 2a str. 2457T 1077231 NP_836478.1 CDS ybiY NC_004741.1 802830 803756 R residues 1 to 308 of 308 are 94.48 pct identical to residues 1 to 308 of 308 from Escherichia coli K-12 : B0824; pyruvate formate-lyase 2 activating enzyme complement(802830..803756) Shigella flexneri 2a str. 2457T 1077232 NP_836479.2 CDS mipB NC_004741.1 803860 804522 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 803860..804522 Shigella flexneri 2a str. 2457T 1077233 NP_836480.1 CDS moeB NC_004741.1 804701 805450 R ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB complement(804701..805450) Shigella flexneri 2a str. 2457T 1077234 NP_836481.1 CDS moeA NC_004741.1 805450 806685 R is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA complement(805450..806685) Shigella flexneri 2a str. 2457T 1077236 NP_836482.1 CDS ybiK NC_004741.1 806889 807854 D residues 1 to 321 of 321 are 95.95 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B0828; L-asparaginase 806889..807854 Shigella flexneri 2a str. 2457T 1077237 NP_836483.1 CDS S0822 NC_004741.1 807874 809712 D with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 807874..809712 Shigella flexneri 2a str. 2457T 1077238 NP_836484.1 CDS S0823 NC_004741.1 809732 811270 D residues 1 to 512 of 512 are 99.41 pct identical to residues 1 to 512 of 512 from Escherichia coli K-12 : B0830; transporter 809732..811270 Shigella flexneri 2a str. 2457T 1077239 NP_836485.1 CDS S0824 NC_004741.1 811288 812208 D residues 1 to 306 of 306 are 87.58 pct identical to residues 1 to 306 of 306 from Escherichia coli K-12 : B0831; transport system permease 811288..812208 Shigella flexneri 2a str. 2457T 1077240 NP_836486.1 CDS S0825 NC_004741.1 812211 813122 D residues 1 to 303 of 303 are 95.04 pct identical to residues 1 to 303 of 303 from Escherichia coli K-12 : B0832; transport system permease 812211..813122 Shigella flexneri 2a str. 2457T 1077241 NP_836487.1 CDS S0827 NC_004741.1 815650 816978 D residues 1 to 442 of 442 are 99.32 pct identical to residues 1 to 442 of 442 from Escherichia coli K-12 : B0834; hypothetical protein 815650..816978 Shigella flexneri 2a str. 2457T 1077244 NP_836488.1 CDS yliG NC_004741.1 817025 818350 R residues 1 to 441 of 441 are 96.82 pct identical to residues 1 to 441 of 441 from Escherichia coli K-12 : B0835; hypothetical protein complement(817025..818350) Shigella flexneri 2a str. 2457T 1077246 NP_836489.1 CDS bssR NC_004741.1 818563 818946 D BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 818563..818946 Shigella flexneri 2a str. 2457T 1077005 NP_836490.1 CDS yliJ NC_004741.1 820168 820800 R residues 1 to 210 of 210 are 89.99 pct identical to residues 1 to 210 of 210 from Escherichia coli K-12 : B0838; transferase complement(820168..820800) Shigella flexneri 2a str. 2457T 1077248 NP_836491.1 CDS S0833 NC_004741.1 822062 822364 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 822062..822364 Shigella flexneri 2a str. 2457T 1077250 NP_836492.1 CDS S0834 NC_004741.1 822505 823218 D residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 822505..823218 Shigella flexneri 2a str. 2457T 1077251 NP_836493.1 CDS deoR NC_004741.1 823555 824313 R residues 1 to 252 of 252 are 94.84 pct identical to residues 1 to 252 of 252 from Escherichia coli K-12 : B0840; DNA-binding transcriptional repressor DeoR complement(823555..824313) Shigella flexneri 2a str. 2457T 1077252 NP_836494.1 CDS ybjG NC_004741.1 824371 824967 R residues 1 to 198 of 198 are 91.41 pct identical to residues 1 to 198 of 198 from Escherichia coli K-12 : B0841; undecaprenyl pyrophosphate phosphatase complement(824371..824967) Shigella flexneri 2a str. 2457T 1077253 NP_836495.1 CDS cmr NC_004741.1 825252 826478 D residues 1 to 408 of 408 are 95.12 pct identical to residues 1 to 410 of 410 from Escherichia coli K-12 : B0842; proton motive force efflux pump; chloramphenicol resistance pump Cmr 825252..826478 Shigella flexneri 2a str. 2457T 1077254 NP_836496.1 CDS ybjH NC_004741.1 826519 826803 R residues 1 to 94 of 94 are 57.44 pct identical to residues 1 to 94 of 94 from Escherichia coli K-12 : B0843; hypothetical protein complement(826519..826803) Shigella flexneri 2a str. 2457T 1077255 NP_836497.1 CDS S0840 NC_004741.1 826889 827677 R residues 1 to 262 of 262 are 98.85 pct identical to residues 1 to 262 of 262 from Escherichia coli K-12 : B0844; hypothetical protein complement(826889..827677) Shigella flexneri 2a str. 2457T 1077257 NP_836498.1 CDS S0841 NC_004741.1 827704 828912 R residues 1 to 402 of 402 are 85.82 pct identical to residues 1 to 402 of 402 from Escherichia coli K-12 : B0845; DEOR-type transcriptional regulator complement(827704..828912) Shigella flexneri 2a str. 2457T 1077258 NP_836499.1 CDS S0842 NC_004741.1 828996 829532 D residues 1 to 178 of 178 are 99.43 pct identical to residues 1 to 178 of 178 from Escherichia coli K-12 : B0846; DEOR-type transcriptional regulator 828996..829532 Shigella flexneri 2a str. 2457T 1077888 NP_836500.1 CDS S0843 NC_004741.1 829707 831392 R residues 1 to 561 of 561 are 93.76 pct identical to residues 1 to 561 of 561 from Escherichia coli K-12 : B0847; hypothetical protein complement(829707..831392) Shigella flexneri 2a str. 2457T 1077259 NP_836501.1 CDS ybjM NC_004741.1 831662 832039 D residues 1 to 125 of 125 are 100.00 pct identical to residues 1 to 125 of 125 from Escherichia coli K-12 : B0848; hypothetical protein 831662..832039 Shigella flexneri 2a str. 2457T 1077626 NP_836502.1 CDS grxA NC_004741.1 832069 832326 R functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin complement(832069..832326) Shigella flexneri 2a str. 2457T 1077260 NP_836503.1 CDS ybjC NC_004741.1 832486 832773 D YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 832486..832773 Shigella flexneri 2a str. 2457T 1077261 NP_836504.1 CDS mdaA NC_004741.1 832757 833479 D NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 832757..833479 Shigella flexneri 2a str. 2457T 1077262 NP_836505.1 CDS rimK NC_004741.1 833540 834442 D responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 833540..834442 Shigella flexneri 2a str. 2457T 1077263 NP_836506.1 CDS ybjN NC_004741.1 834530 835006 D residues 1 to 158 of 158 are 100.00 pct identical to residues 1 to 158 of 158 from Escherichia coli K-12 : B0853; sensory transduction regulator 834530..835006 Shigella flexneri 2a str. 2457T 1077264 NP_836507.1 CDS potF NC_004741.1 835358 836470 D residues 1 to 370 of 370 are 99.72 pct identical to residues 1 to 370 of 370 from Escherichia coli K-12 : B0854; putrescine transporter subunit: periplasmic-binding component of ABC superfamily 835358..836470 Shigella flexneri 2a str. 2457T 1077265 NP_836508.2 CDS potG NC_004741.1 836565 837698 D part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding subunit 836565..837698 Shigella flexneri 2a str. 2457T 1077266 NP_836509.1 CDS potH NC_004741.1 837708 838661 D residues 1 to 317 of 317 are 89.90 pct identical to residues 1 to 317 of 317 from Escherichia coli K-12 : B0856; putrescine transporter subunit: membrane component of ABC superfamily 837708..838661 Shigella flexneri 2a str. 2457T 1077267 NP_836510.1 CDS potI NC_004741.1 838658 839503 D residues 1 to 281 of 281 are 86.47 pct identical to residues 1 to 281 of 281 from Escherichia coli K-12 : B0857; putrescine transporter subunit: membrane component of ABC superfamily 838658..839503 Shigella flexneri 2a str. 2457T 1077268 NP_836511.1 CDS ybjO NC_004741.1 839563 840051 D residues 1 to 162 of 162 are 91.35 pct identical to residues 1 to 162 of 162 from Escherichia coli K-12 : B0858; hypothetical protein 839563..840051 Shigella flexneri 2a str. 2457T 1077269 NP_836512.1 CDS rumB NC_004741.1 840092 841219 D RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 840092..841219 Shigella flexneri 2a str. 2457T 1080932 NP_836513.1 CDS artJ NC_004741.1 841394 842125 R residues 1 to 243 of 243 are 92.18 pct identical to residues 1 to 243 of 243 from Escherichia coli K-12 : B0860; arginine 3rd transport system periplasmic binding protein complement(841394..842125) Shigella flexneri 2a str. 2457T 1077270 NP_836514.1 CDS artM NC_004741.1 842417 843085 R with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM complement(842417..843085) Shigella flexneri 2a str. 2457T 1077271 NP_836515.1 CDS artQ NC_004741.1 843085 843801 R with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ complement(843085..843801) Shigella flexneri 2a str. 2457T 1077272 NP_836516.1 CDS artI NC_004741.1 843808 844539 R residues 1 to 243 of 243 are 99.17 pct identical to residues 1 to 243 of 243 from Escherichia coli K-12 : B0863; arginine 3rd transport system periplasmic binding protein complement(843808..844539) Shigella flexneri 2a str. 2457T 1077273 NP_836517.1 CDS artP NC_004741.1 844557 845285 R With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit complement(844557..845285) Shigella flexneri 2a str. 2457T 1077274 NP_836518.1 CDS ybjP NC_004741.1 845503 846018 R induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; lipoprotein complement(845503..846018) Shigella flexneri 2a str. 2457T 1077275 NP_836519.1 CDS S4813 NC_004741.1 846032 846214 R residues 1 to 61 of 61 are 100.00 pct identical to residues 1 to 61 of 61 from NP_286635.1, Z1096 gene product Escherichia coli O157:H7 EDL933; hypothetical protein complement(846032..846214) Shigella flexneri 2a str. 2457T 1077276 NP_836520.1 CDS S4814 NC_004741.1 846667 848436 D residues 1 to 402 of 589 are 94.52 pct identical to residues 12 to 412 of 413 from NP_286636.1 Z1097 gene product Escherichia coli O157:H7 EDL933, NP_308976.1 hypothetical protein Escherichia coli O157:H7; E90747 hypothetical protein ECs0949 Escherichia coli (strain O157:H7, substrain RIMD 0509952), B85598 hypothetical protein Z1097; hypothetical protein 846667..848436 Shigella flexneri 2a str. 2457T 1077277 NP_836521.1 CDS S0862 NC_004741.1 848646 848969 D residues 1 to 107 of 107 are 99.06 pct identical to residues 1 to 107 of 107 from Escherichia coli K-12 : B0866; hypothetical protein 848646..848969 Shigella flexneri 2a str. 2457T 1077278 NP_836522.1 CDS S0863 NC_004741.1 848966 849796 D residues 1 to 276 of 276 are 94.92 pct identical to residues 1 to 276 of 276 from Escherichia coli K-12 : B0867; regulator 848966..849796 Shigella flexneri 2a str. 2457T 1077279 NP_836523.1 CDS S0864 NC_004741.1 849793 850842 R residues 1 to 349 of 349 are 98.56 pct identical to residues 1 to 349 of 349 from Escherichia coli K-12 : B0868; nucleotide di-P-sugar epimerase or dehydratase complement(849793..850842) Shigella flexneri 2a str. 2457T 1077280 NP_836524.1 CDS ybjT NC_004741.1 850905 852335 R residues 1 to 476 of 476 are 96.00 pct identical to residues 11 to 486 of 486 from Escherichia coli K-12 : B0869; dTDP-glucose enzyme complement(850905..852335) Shigella flexneri 2a str. 2457T 1077281 NP_836525.1 CDS ybjU NC_004741.1 852346 853347 R low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase complement(852346..853347) Shigella flexneri 2a str. 2457T 1077282 NP_836526.1 CDS poxB NC_004741.1 853384 855102 R catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase complement(853384..855102) Shigella flexneri 2a str. 2457T 1077283 NP_836527.1 CDS S0868 NC_004741.1 855235 856203 R residues 1 to 322 of 322 are 94.40 pct identical to residues 1 to 322 of 322 from Escherichia coli K-12 : B0872; HCP oxidoreductase, NADH-dependent complement(855235..856203) Shigella flexneri 2a str. 2457T 1077284 NP_836528.2 CDS ybjW NC_004741.1 856215 857867 R catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase complement(856215..857867) Shigella flexneri 2a str. 2457T 1077285 NP_836529.1 CDS ybjE NC_004741.1 858011 858958 R residues 1 to 315 of 315 are 87.61 pct identical to residues 1 to 315 of 315 from Escherichia coli K-12 : B0874; surface protein complement(858011..858958) Shigella flexneri 2a str. 2457T 1077286 NP_836530.2 CDS S0871 NC_004741.1 859034 859939 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(859034..859939) Shigella flexneri 2a str. 2457T 1077287 NP_836531.2 CDS S0872 NC_004741.1 859897 860262 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(859897..860262) Shigella flexneri 2a str. 2457T 1077288 NP_836532.1 CDS aqpZ NC_004741.1 860703 861398 R porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z complement(860703..861398) Shigella flexneri 2a str. 2457T 1077289 NP_836533.1 CDS S0874 NC_004741.1 861450 861953 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(861450..861953) Shigella flexneri 2a str. 2457T 1077290 NP_836534.1 CDS S0875 NC_004741.1 861872 862147 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(861872..862147) Shigella flexneri 2a str. 2457T 1077291 NP_836535.1 CDS ybjD NC_004741.1 862599 864257 D residues 1 to 552 of 552 are 97.10 pct identical to residues 1 to 552 of 552 from Escherichia coli K-12 : B0876; hypothetical protein 862599..864257 Shigella flexneri 2a str. 2457T 1077292 NP_836536.1 CDS ybjX NC_004741.1 864254 865246 R residues 1 to 330 of 330 are 95.75 pct identical to residues 1 to 330 of 330 from Escherichia coli K-12 : B0877; enzyme complement(864254..865246) Shigella flexneri 2a str. 2457T 1080446 NP_836537.1 CDS S0878 NC_004741.1 865361 866476 D confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 865361..866476 Shigella flexneri 2a str. 2457T 1077293 NP_836538.1 CDS ybjZ NC_004741.1 866473 868419 D with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 866473..868419 Shigella flexneri 2a str. 2457T 1077294 NP_836539.1 CDS cspD NC_004741.1 868492 868716 R inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD complement(868492..868716) Shigella flexneri 2a str. 2457T 1077295 NP_836540.1 CDS clpS NC_004741.1 869039 869359 D involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 869039..869359 Shigella flexneri 2a str. 2457T 1077296 NP_836541.1 CDS clpA NC_004741.1 869390 871666 D ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 869390..871666 Shigella flexneri 2a str. 2457T 1077297 NP_836542.1 CDS infA NC_004741.1 872410 872628 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(872410..872628) Shigella flexneri 2a str. 2457T 1077299 NP_836543.1 CDS aat NC_004741.1 872913 873617 R leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase complement(872913..873617) Shigella flexneri 2a str. 2457T 1077300 NP_836544.1 CDS cydC NC_004741.1 873659 875380 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component complement(873659..875380) Shigella flexneri 2a str. 2457T 1080456 NP_836545.1 CDS cydD NC_004741.1 875381 877147 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component complement(875381..877147) Shigella flexneri 2a str. 2457T 1077301 NP_836546.1 CDS trxB NC_004741.1 877270 878235 R catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase complement(877270..878235) Shigella flexneri 2a str. 2457T 1077302 NP_836547.1 CDS lrp NC_004741.1 878779 879273 D mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 878779..879273 Shigella flexneri 2a str. 2457T 1077303 NP_836548.1 CDS ftsK NC_004741.1 879408 883436 D DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 879408..883436 Shigella flexneri 2a str. 2457T 1077304 NP_836549.1 CDS lolA NC_004741.1 883588 884202 D participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 883588..884202 Shigella flexneri 2a str. 2457T 1077306 NP_836550.1 CDS ycaJ NC_004741.1 884213 885556 D residues 1 to 447 of 447 are 99.55 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 : B0892; recombination factor protein RarA 884213..885556 Shigella flexneri 2a str. 2457T 1077307 NP_836551.1 CDS serS NC_004741.1 885647 886939 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 885647..886939 Shigella flexneri 2a str. 2457T 1077308 NP_836552.1 CDS dmsA NC_004741.1 887266 889623 D residues 1 to 785 of 785 are 98.47 pct identical to residues 1 to 785 of 785 from Escherichia coli K-12 : B0894; anaerobic dimethyl sulfoxide reductase subunit A 887266..889623 Shigella flexneri 2a str. 2457T 1076457 NP_836553.1 CDS dmsB NC_004741.1 889634 890251 D residues 1 to 205 of 205 are 100.00 pct identical to residues 1 to 205 of 205 from Escherichia coli K-12 : B0895; anaerobic dimethyl sulfoxide reductase subunit B 889634..890251 Shigella flexneri 2a str. 2457T 1077309 NP_836554.1 CDS dmsC NC_004741.1 890253 891044 D residues 1 to 263 of 263 are 85.01 pct identical to residues 1 to 287 of 287 from Escherichia coli K-12 : B0896; anaerobic dimethyl sulfoxide reductase subunit C 890253..891044 Shigella flexneri 2a str. 2457T 1077310 NP_836555.1 CDS ycaC NC_004741.1 891080 891706 R residues 1 to 208 of 208 are 98.55 pct identical to residues 1 to 208 of 208 from Escherichia coli K-12 : B0897; hypothetical protein complement(891080..891706) Shigella flexneri 2a str. 2457T 1077311 NP_836556.1 CDS ycaD NC_004741.1 892021 893169 D residues 1 to 382 of 382 are 90.31 pct identical to residues 1 to 382 of 382 from Escherichia coli K-12 : B0898; MFS family transporter protein 892021..893169 Shigella flexneri 2a str. 2457T 1076630 NP_836557.1 CDS S0899 NC_004741.1 893482 894156 D residues 1 to 224 of 224 are 99.10 pct identical to residues 1 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 893482..894156 Shigella flexneri 2a str. 2457T 1077312 NP_836558.1 CDS S0900 NC_004741.1 894153 894503 D residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAK18528.1|AF348706_217 (AF348706) IS orf [Shigella flexneri]; partial; ISSfl3 orfB 894153..894503 Shigella flexneri 2a str. 2457T 1077313 NP_836559.1 CDS S0901 NC_004741.1 894500 896101 D residues 1 to 533 of 533 are 97.37 pct identical to residues 1 to 533 of 533 from GenPept : >gb|AAL72376.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfC,D 894500..896101 Shigella flexneri 2a str. 2457T 1077314 NP_836560.1 CDS S0905 NC_004741.1 897507 897809 R residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA complement(897507..897809) Shigella flexneri 2a str. 2457T 1077315 NP_836561.1 CDS S0906 NC_004741.1 897790 897996 R residues 1 to 38 of 68 are 100.00 pct identical to residues 41 to 78 of 172 from GenPept : >gb|AAG56426.1|AE005369_15 (AE005369) unknown protein encoded within prophage CP-933R [Escherichia coli O157:H7 EDL933]; bacteriophage protein complement(897790..897996) Shigella flexneri 2a str. 2457T 1077372 NP_836562.1 CDS S0907 NC_004741.1 897993 898283 R residues 1 to 96 of 96 are 96.87 pct identical to residues 1 to 96 of 96 from GenPept : >emb|CAD05594.1| (AL627272) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein complement(897993..898283) Shigella flexneri 2a str. 2457T 1077316 NP_836563.1 CDS S0908 NC_004741.1 898283 898414 R residues 1 to 43 of 43 are 97.67 pct identical to residues 157 to 199 of 199 from GenPept : >emb|CAD05595.1| (AL627272) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(898283..898414) Shigella flexneri 2a str. 2457T 1077317 NP_836564.1 CDS S0909 NC_004741.1 898581 898883 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 898581..898883 Shigella flexneri 2a str. 2457T 1077318 NP_836565.1 CDS S0910 NC_004741.1 899024 899737 D residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 899024..899737 Shigella flexneri 2a str. 2457T 1077319 NP_836566.1 CDS S0911 NC_004741.1 899777 900148 R residues 1 to 123 of 123 are 97.56 pct identical to residues 1 to 123 of 199 from GenPept : >gb|AAG56427.1|AE005369_16 (AE005369) unknown protein encoded within prophage CP-933R [Escherichia coli O157:H7 EDL933]; hypothetical protein complement(899777..900148) Shigella flexneri 2a str. 2457T 1077320 NP_836567.1 CDS S0912 NC_004741.1 900724 900822 R residues 1 to 32 of 32 are 93.75 pct identical to residues 39 to 70 of 70 from GenPept : >emb|CAD05598.1| (AL627272) host cell-killing modulation protein [Salmonella enterica subsp. enterica serovar Typhi]; host cell-killing modulation protein complement(900724..900822) Shigella flexneri 2a str. 2457T 1077321 NP_836568.1 CDS S0913 NC_004741.1 901106 901672 R residues 1 to 183 of 188 are 81.42 pct identical to residues 33 to 215 of 236 from GenPept : >gb|AAF85072.1|AE004039_7 (AE004039) conserved hypothetical protein [Xylella fastidiosa 9a5c]; hypothetical protein complement(901106..901672) Shigella flexneri 2a str. 2457T 1077322 NP_836569.1 CDS S0914 NC_004741.1 902354 902776 R residues 1 to 140 of 140 are 69.99 pct identical to residues 1 to 140 of 140 from GenPept : >gb|AAG56435.1|AE005370_8 (AE005370) unknown protein encoded within prophage CP-933R [Escherichia coli O157:H7 EDL933]; bacteriophage protein complement(902354..902776) Shigella flexneri 2a str. 2457T 1077323 NP_836570.1 CDS S0917 NC_004741.1 903683 904321 R residues 1 to 201 of 212 are 97.01 pct identical to residues 1 to 201 of 262 from GenPept : >emb|CAD05607.1| (AL627272) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein complement(903683..904321) Shigella flexneri 2a str. 2457T 1077325 NP_836571.1 CDS S0918 NC_004741.1 904399 904821 R residues 1 to 127 of 140 are 88.97 pct identical to residues 1 to 127 of 140 from GenPept : >emb|CAD05608.1| (AL627272) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein complement(904399..904821) Shigella flexneri 2a str. 2457T 1077326 NP_836572.1 CDS S0919 NC_004741.1 904805 905032 R residues 1 to 73 of 75 are 90.41 pct identical to residues 1 to 73 of 75 from GenPept : >gb|AAG56121.1|AE005343_11 (AE005343) regulator of cell division encoded by prophage CP-933O [Escherichia coli O157:H7 EDL933]; DNA-binding transcriptional regulator DicC complement(904805..905032) Shigella flexneri 2a str. 2457T 1077327 NP_836573.1 CDS S0920 NC_004741.1 905720 905875 D residues 1 to 51 of 51 are 92.15 pct identical to residues 1 to 51 of 51 from GenPept : >emb|CAD05611.1| (AL627272) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 905720..905875 Shigella flexneri 2a str. 2457T 1080797 NP_836574.1 CDS S0921 NC_004741.1 905877 906080 D residues 1 to 67 of 67 are 97.01 pct identical to residues 1 to 67 of 67 from GenPept : >emb|CAD05612.1| (AL627272) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 905877..906080 Shigella flexneri 2a str. 2457T 1080953 NP_836575.2 CDS S0922 NC_004741.1 906322 907227 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(906322..907227) Shigella flexneri 2a str. 2457T 1077328 NP_836576.2 CDS S0923 NC_004741.1 907185 907550 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(907185..907550) Shigella flexneri 2a str. 2457T 1080078 NP_836577.1 CDS S0924 NC_004741.1 908098 908637 D residues 1 to 179 of 179 are 85.47 pct identical to residues 1 to 179 of 179 from GenPept : >emb|CAA80648.1| (Z23101) Sequence similarity to P4 ORF199 suggests ORF179 expression [Shigella flexneri]; bacteriophage protein 908098..908637 Shigella flexneri 2a str. 2457T 1077329 NP_836578.1 CDS S0925 NC_004741.1 908598 908945 D no significant similarities; hypothetical protein 908598..908945 Shigella flexneri 2a str. 2457T 1077330 NP_836579.1 CDS S0927 NC_004741.1 909459 909761 D residues 1 to 100 of 100 are 99.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 909459..909761 Shigella flexneri 2a str. 2457T 1077331 NP_836580.1 CDS S0928 NC_004741.1 909902 910615 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 909902..910615 Shigella flexneri 2a str. 2457T 1077332 NP_836581.1 CDS S0929 NC_004741.1 910640 911284 R residues 1 to 182 of 214 are 59.89 pct identical to residues 1 to 178 of 866 from GenPept : >gb|AAG56447.1|AE005371_3 (AE005371) exodeoxyribonuclease VIII of prophage CP-933R [Escherichia coli O157:H7 EDL933]; exodeoxyribonuclease VIII of prophage CP-933R complement(910640..911284) Shigella flexneri 2a str. 2457T 1077333 NP_836582.1 CDS S0930 NC_004741.1 911628 912068 R residues 1 to 146 of 146 are 100.00 pct identical to residues 1 to 146 of 146 from GenPept : >gb|AAL72524.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS600 orfB complement(911628..912068) Shigella flexneri 2a str. 2457T 1077334 NP_836583.1 CDS S0931 NC_004741.1 912483 912785 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA complement(912483..912785) Shigella flexneri 2a str. 2457T 1077335 NP_836584.1 CDS S0932 NC_004741.1 912851 913468 D residues 19 to 205 of 205 are 71.12 pct identical to residues 2 to 188 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein 912851..913468 Shigella flexneri 2a str. 2457T 1077336 NP_836585.1 CDS ipaH_2 NC_004741.1 913648 915474 R residues 1 to 608 of 608 are 63.71 pct identical to residues 1 to 565 of 565 from NRprotein_Feb03 : >ref|NP_085238.1| invasion plasmid antigen [Shigella flexneri] emb|CAC05787.1| IpaH7.8, member of the IpaH family, secreted by the Mxi-Spa secretion machinery, function unknown [Shigella flexneri]; invasion plasmid antigen complement(913648..915474) Shigella flexneri 2a str. 2457T 1077585 NP_836586.1 CDS ybhE NC_004741.1 916356 917351 D catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 916356..917351 Shigella flexneri 2a str. 2457T 1079910 NP_836587.1 CDS ybhH NC_004741.1 918634 919581 D residues 1 to 315 of 315 are 99.68 pct identical to residues 36 to 350 of 350 from Escherichia coli K-12 : B0769; hypothetical protein 918634..919581 Shigella flexneri 2a str. 2457T 1077338 NP_836588.1 CDS ybhI NC_004741.1 919720 921090 D residues 1 to 456 of 456 are 97.36 pct identical to residues 22 to 477 of 477 from Escherichia coli K-12 : B0770; membrane pump protein 919720..921090 Shigella flexneri 2a str. 2457T 1077339 NP_836589.1 CDS ybhJ NC_004741.1 921273 923453 D residues 1 to 726 of 726 are 96.41 pct identical to residues 9 to 761 of 761 from Escherichia coli K-12 : B0771; enzyme 921273..923453 Shigella flexneri 2a str. 2457T 1077341 NP_836590.1 CDS ybhC NC_004741.1 923594 924877 R outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; pectinesterase complement(923594..924877) Shigella flexneri 2a str. 2457T 1077342 NP_836591.1 CDS S0941 NC_004741.1 925012 925782 R residues 1 to 256 of 256 are 100.00 pct identical to residues 32 to 287 of 287 from GenPept : >gb|AAG55102.1|AE005255_3 (AE005255) integrase encoded by prophage CP-933K; [Escherichia coli O157:H7 EDL933]; integrase encoded by prophage CP-933K; partial complement(925012..925782) Shigella flexneri 2a str. 2457T 1077343 NP_836592.1 CDS S0942 NC_004741.1 925994 926707 R residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB complement(925994..926707) Shigella flexneri 2a str. 2457T 1077344 NP_836593.1 CDS S0943 NC_004741.1 926848 927150 R residues 1 to 100 of 100 are 99.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA complement(926848..927150) Shigella flexneri 2a str. 2457T 1077345 NP_836594.1 CDS S0944 NC_004741.1 927343 927771 D residues 1 to 101 of 142 are 78.21 pct identical to residues 1 to 101 of 165 from GenPept : >gb|AAG55116.1|AE005256_7 (AE005256) lysozyme protein R of prophage CP-933K [Escherichia coli O157:H7 EDL933]; lysozyme protein R of prophage CP-933K 927343..927771 Shigella flexneri 2a str. 2457T 1077346 NP_836595.1 CDS S0945 NC_004741.1 927896 928393 D residues 1 to 165 of 165 are 98.18 pct identical to residues 60 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 927896..928393 Shigella flexneri 2a str. 2457T 1077347 NP_836596.1 CDS S0946 NC_004741.1 928390 928740 D residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAK18528.1|AF348706_217 (AF348706) IS orf [Shigella flexneri]; ISSfl3 orfB 928390..928740 Shigella flexneri 2a str. 2457T 1077348 NP_836597.1 CDS S0947 NC_004741.1 928737 929279 D residues 1 to 165 of 180 are 92.12 pct identical to residues 1 to 165 of 533 from GenPept : >gb|AAL72472.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfC 928737..929279 Shigella flexneri 2a str. 2457T 1077349 NP_836598.1 CDS S0948 NC_004741.1 929285 929611 D residues 1 to 108 of 108 are 71.29 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAF09023.1| (AF139596) unknown [Shigella flexneri]; IS629 orfA 929285..929611 Shigella flexneri 2a str. 2457T 1077350 NP_836599.1 CDS S0949 NC_004741.1 929611 930498 D residues 1 to 295 of 295 are 98.64 pct identical to residues 2 to 296 of 296 from GenPept : >gb|AAL67398.1|AF447814_66 (AF447814) transposase [Escherichia coli]; IS629 orfB 929611..930498 Shigella flexneri 2a str. 2457T 1077351 NP_836600.1 CDS S0950 NC_004741.1 930482 930670 D residues 21 to 62 of 62 are 100.00 pct identical to residues 492 to 533 of 533 from GenPept : >gb|AAL72472.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; hypothetical protein 930482..930670 Shigella flexneri 2a str. 2457T 1077352 NP_836601.1 CDS S0952 NC_004741.1 931204 931479 D residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 931204..931479 Shigella flexneri 2a str. 2457T 1077355 NP_836602.1 CDS S0953 NC_004741.1 931398 931901 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 931398..931901 Shigella flexneri 2a str. 2457T 1077356 NP_836603.1 CDS S0956 NC_004741.1 933145 933447 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 933145..933447 Shigella flexneri 2a str. 2457T 1077359 NP_836604.1 CDS S0957 NC_004741.1 933588 934301 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 933588..934301 Shigella flexneri 2a str. 2457T 1077360 NP_836605.1 CDS S0958 NC_004741.1 934544 935047 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(934544..935047) Shigella flexneri 2a str. 2457T 1077361 NP_836606.1 CDS S0959 NC_004741.1 935162 935875 R residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB complement(935162..935875) Shigella flexneri 2a str. 2457T 1077362 NP_836607.1 CDS S0960 NC_004741.1 936016 936318 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA complement(936016..936318) Shigella flexneri 2a str. 2457T 1077364 NP_836608.1 CDS pflA NC_004741.1 936727 937467 R activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 complement(936727..937467) Shigella flexneri 2a str. 2457T 1077365 NP_836609.1 CDS pflB NC_004741.1 937659 939941 R residues 1 to 760 of 760 are 96.31 pct identical to residues 1 to 760 of 760 from Escherichia coli K-12 : B0903; formate acetyltransferase 1 complement(937659..939941) Shigella flexneri 2a str. 2457T 1077366 NP_836610.1 CDS focA NC_004741.1 939996 940853 R residues 1 to 285 of 285 are 95.08 pct identical to residues 1 to 285 of 285 from Escherichia coli K-12 : B0904; formate transporter complement(939996..940853) Shigella flexneri 2a str. 2457T 1077367 NP_836611.1 CDS ycaO NC_004741.1 941259 943019 R residues 1 to 586 of 586 are 96.75 pct identical to residues 4 to 589 of 589 from Escherichia coli K-12 : B0905; hypothetical protein complement(941259..943019) Shigella flexneri 2a str. 2457T 1077368 NP_836612.1 CDS serC NC_004741.1 943974 945062 D catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 943974..945062 Shigella flexneri 2a str. 2457T 1077371 NP_836613.1 CDS aroA NC_004741.1 945133 946416 D catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 945133..946416 Shigella flexneri 2a str. 2457T 1077373 NP_836614.1 CDS yi41 NC_004741.1 946560 947888 D residues 1 to 442 of 442 are 99.54 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 946560..947888 Shigella flexneri 2a str. 2457T 1077374 NP_836615.1 CDS ycaL NC_004741.1 948024 948788 D residues 1 to 254 of 254 are 93.70 pct identical to residues 9 to 262 of 262 from Escherichia coli K-12 : B0909; heat shock protein 948024..948788 Shigella flexneri 2a str. 2457T 1077376 NP_836616.1 CDS cmk NC_004741.1 948961 949644 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 948961..949644 Shigella flexneri 2a str. 2457T 1077363 NP_836617.1 CDS rpsA NC_004741.1 949755 951428 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 949755..951428 Shigella flexneri 2a str. 2457T 1077377 NP_836618.1 CDS ihfB NC_004741.1 951588 951872 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 951588..951872 Shigella flexneri 2a str. 2457T 1077378 NP_836619.1 CDS msbA NC_004741.1 954375 956123 D involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 954375..956123 Shigella flexneri 2a str. 2457T 1077381 NP_836620.1 CDS lpxK NC_004741.1 956120 957106 D transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 956120..957106 Shigella flexneri 2a str. 2457T 1077382 NP_836621.1 CDS ycaQ NC_004741.1 957143 958375 D residues 1 to 410 of 410 are 95.12 pct identical to residues 1 to 410 of 410 from Escherichia coli K-12 : B0916; hypothetical protein 957143..958375 Shigella flexneri 2a str. 2457T 1077383 NP_836622.1 CDS ycaR NC_004741.1 958427 958609 D residues 1 to 60 of 60 are 100.00 pct identical to residues 1 to 60 of 60 from Escherichia coli K-12 : B0917; hypothetical protein 958427..958609 Shigella flexneri 2a str. 2457T 1077384 NP_836623.1 CDS kdsB NC_004741.1 958606 959352 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 958606..959352 Shigella flexneri 2a str. 2457T 1077385 NP_836624.1 CDS S0979 NC_004741.1 959506 960399 D residues 1 to 297 of 297 are 100.00 pct identical to residues 1 to 297 of 297 from Escherichia coli K-12 : B0919; hypothetical protein 959506..960399 Shigella flexneri 2a str. 2457T 1077386 NP_836625.1 CDS ycbC NC_004741.1 960376 961155 R residues 1 to 259 of 259 are 89.18 pct identical to residues 1 to 259 of 259 from Escherichia coli K-12 : B0920; hypothetical protein complement(960376..961155) Shigella flexneri 2a str. 2457T 1080993 NP_836626.1 CDS smtA NC_004741.1 961291 962076 D involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 961291..962076 Shigella flexneri 2a str. 2457T 1077387 NP_836627.1 CDS mukF NC_004741.1 962073 963395 D acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 962073..963395 Shigella flexneri 2a str. 2457T 1077389 NP_836628.1 CDS mukE NC_004741.1 963403 964080 D acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 963403..964080 Shigella flexneri 2a str. 2457T 1077390 NP_836629.1 CDS mukB NC_004741.1 964080 968540 D SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 964080..968540 Shigella flexneri 2a str. 2457T 1077391 NP_836630.1 CDS S0985 NC_004741.1 968703 970031 D residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 968703..970031 Shigella flexneri 2a str. 2457T 1077393 NP_836631.1 CDS ycbB NC_004741.1 970239 972086 D residues 1 to 615 of 615 are 96.58 pct identical to residues 1 to 615 of 615 from Escherichia coli K-12 : B0925; hypothetical protein 970239..972086 Shigella flexneri 2a str. 2457T 1077394 NP_836632.1 CDS ycbK NC_004741.1 972267 972815 D residues 1 to 182 of 182 are 93.40 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 : B0926; hypothetical protein 972267..972815 Shigella flexneri 2a str. 2457T 1077395 NP_836633.1 CDS ycbL NC_004741.1 972842 973489 D residues 1 to 215 of 215 are 99.53 pct identical to residues 1 to 215 of 215 from Escherichia coli K-12 : B0927; hypothetical protein 972842..973489 Shigella flexneri 2a str. 2457T 1077396 NP_836634.1 CDS aspC NC_004741.1 973712 974902 R catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase complement(973712..974902) Shigella flexneri 2a str. 2457T 1077370 NP_836635.1 CDS ompF NC_004741.1 975087 976175 R outer membrane porin F; 1a; Ia; b; outer membrane protein F complement(975087..976175) Shigella flexneri 2a str. 2457T 1077397 NP_836636.1 CDS asnC NC_004741.1 976776 978176 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(976776..978176) Shigella flexneri 2a str. 2457T 1077398 NP_836637.1 CDS pncB NC_004741.1 978345 979547 R catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(978345..979547) Shigella flexneri 2a str. 2457T 1077392 NP_836638.1 CDS pepN NC_004741.1 979813 982428 D residues 1 to 871 of 871 are 95.63 pct identical to residues 1 to 870 of 870 from Escherichia coli K-12 : B0932; aminopeptidase N 979813..982428 Shigella flexneri 2a str. 2457T 1077399 NP_836639.1 CDS ssuB NC_004741.1 982635 983402 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit complement(982635..983402) Shigella flexneri 2a str. 2457T 1077400 NP_836640.2 CDS S0996 NC_004741.1 984027 984932 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(984027..984932) Shigella flexneri 2a str. 2457T 1077403 NP_836641.2 CDS S0997 NC_004741.1 984890 985255 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(984890..985255) Shigella flexneri 2a str. 2457T 1077404 NP_836642.1 CDS ycbN NC_004741.1 985538 986683 R catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase complement(985538..986683) Shigella flexneri 2a str. 2457T 1077423 NP_836643.2 CDS ycbO NC_004741.1 986680 987639 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit complement(986680..987639) Shigella flexneri 2a str. 2457T 1077405 NP_836644.1 CDS ycbP NC_004741.1 987632 988207 R residues 1 to 191 of 191 are 92.67 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B0937; NAD(P)H-dependent FMN reductase complement(987632..988207) Shigella flexneri 2a str. 2457T 1077406 NP_836645.1 CDS S1002 NC_004741.1 988345 989040 D residues 78 to 231 of 231 are 82.46 pct identical to residues 16 to 167 of 167 from GenPept : >gb|AAK18538.1|AF348706_227 (AF348706) IS1 orfB [Shigella flexneri]; partial; IS1 orfB, A 988345..989040 Shigella flexneri 2a str. 2457T 1077407 NP_836646.1 CDS S1004 NC_004741.1 989411 989914 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(989411..989914) Shigella flexneri 2a str. 2457T 1077409 NP_836647.1 CDS S1005 NC_004741.1 989833 990108 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(989833..990108) Shigella flexneri 2a str. 2457T 1077410 NP_836648.1 CDS ycbS NC_004741.1 990248 992848 D residues 1 to 866 of 866 are 94.91 pct identical to residues 1 to 866 of 866 from Escherichia coli K-12 : B0940; outer membrane protein 990248..992848 Shigella flexneri 2a str. 2457T 1080983 NP_836649.1 CDS S1007 NC_004741.1 992839 993822 D residues 1 to 325 of 327 are 89.84 pct identical to residues 1 to 325 of 356 from Escherichia coli K-12 : B0941; fimbrial protein 992839..993822 Shigella flexneri 2a str. 2457T 1077411 NP_836650.1 CDS S1008 NC_004741.1 993920 994462 D residues 1 to 180 of 180 are 92.22 pct identical to residues 1 to 180 of 180 from Escherichia coli K-12 : B0942; fimbrial-like protein 993920..994462 Shigella flexneri 2a str. 2457T 1077412 NP_836651.1 CDS S1009 NC_004741.1 994422 994985 D residues 1 to 187 of 187 are 90.90 pct identical to residues 1 to 187 of 187 from Escherichia coli K-12 : B0943; fimbrial-like protein 994422..994985 Shigella flexneri 2a str. 2457T 1077413 NP_836652.1 CDS ycbF NC_004741.1 994951 995688 D residues 1 to 245 of 245 are 82.85 pct identical to residues 1 to 245 of 245 from Escherichia coli K-12 : B0944; putativi pili assembly chaperone 994951..995688 Shigella flexneri 2a str. 2457T 1077414 NP_836653.1 CDS pyrD NC_004741.1 995800 996810 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 995800..996810 Shigella flexneri 2a str. 2457T 1077415 NP_836654.1 CDS ycbW NC_004741.1 996948 997526 D residues 1 to 192 of 192 are 99.47 pct identical to residues 1 to 192 of 192 from Escherichia coli K-12 : B0946; hypothetical protein 996948..997526 Shigella flexneri 2a str. 2457T 1077416 NP_836655.1 CDS S1013 NC_004741.1 997523 998632 R residues 1 to 369 of 369 are 95.66 pct identical to residues 1 to 369 of 369 from Escherichia coli K-12 : B0947; hypothetical protein complement(997523..998632) Shigella flexneri 2a str. 2457T 1077419 NP_836656.1 CDS rlmL NC_004741.1 998876 1000984 D catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 998876..1000984 Shigella flexneri 2a str. 2457T 1077420 NP_836657.1 CDS uup NC_004741.1 1000996 1002903 D Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1000996..1002903 Shigella flexneri 2a str. 2457T 1077561 NP_836658.1 CDS pqiA NC_004741.1 1003033 1004286 D residues 1 to 417 of 417 are 96.40 pct identical to residues 1 to 417 of 417 from Escherichia coli K-12 : B0950; paraquat-inducible protein A 1003033..1004286 Shigella flexneri 2a str. 2457T 1077422 NP_836659.1 CDS pqiB NC_004741.1 1004291 1005931 D residues 1 to 546 of 546 are 97.43 pct identical to residues 1 to 546 of 546 from Escherichia coli K-12 : B0951; paraquat-inducible protein B 1004291..1005931 Shigella flexneri 2a str. 2457T 1077516 NP_836660.1 CDS ymbA NC_004741.1 1005928 1006491 D residues 6 to 187 of 187 are 99.45 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 : B0952; hypothetical protein 1005928..1006491 Shigella flexneri 2a str. 2457T 1077424 NP_836661.1 CDS rmf NC_004741.1 1006747 1006914 D residues 1 to 55 of 55 are 98.18 pct identical to residues 1 to 55 of 55 from Escherichia coli K-12 : B0953; ribosome modulation factor 1006747..1006914 Shigella flexneri 2a str. 2457T 1077425 NP_836662.1 CDS fabA NC_004741.1 1006984 1007502 R catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase complement(1006984..1007502) Shigella flexneri 2a str. 2457T 1077245 NP_836663.1 CDS S1021 NC_004741.1 1007571 1009331 R residues 1 to 586 of 586 are 97.44 pct identical to residues 1 to 586 of 586 from Escherichia coli K-12 : B0955; ATP-dependent protease complement(1007571..1009331) Shigella flexneri 2a str. 2457T 1077426 NP_836664.1 CDS ycbG NC_004741.1 1009516 1009968 D residues 1 to 150 of 150 are 100.00 pct identical to residues 1 to 150 of 150 from Escherichia coli K-12 : B0956; hypothetical protein 1009516..1009968 Shigella flexneri 2a str. 2457T 1077427 NP_836665.1 CDS ompA NC_004741.1 1010044 1011090 R OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A complement(1010044..1011090) Shigella flexneri 2a str. 2457T 1077401 NP_836666.1 CDS sulA NC_004741.1 1011446 1011955 R residues 1 to 169 of 169 are 79.88 pct identical to residues 1 to 169 of 169 from Escherichia coli K-12 : B0958; suppressor of lon; SOS cell division inhibitor complement(1011446..1011955) Shigella flexneri 2a str. 2457T 1077428 NP_836667.1 CDS S1025 NC_004741.1 1012174 1012599 D residues 1 to 137 of 141 are 100.00 pct identical to residues 1 to 137 of 209 from Escherichia coli K-12 : B0959; hypothetical protein 1012174..1012599 Shigella flexneri 2a str. 2457T 1077353 NP_836668.2 CDS S1026 NC_004741.1 1012675 1013040 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1012675..1013040 Shigella flexneri 2a str. 2457T 1080912 NP_836669.1 CDS S1027 NC_004741.1 1013019 1013651 D residues 1 to 195 of 195 are 98.97 pct identical to residues 23 to 217 of 301 from GenPept : >gb|AAL72414.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS2 orfB 1013019..1013651 Shigella flexneri 2a str. 2457T 1077429 NP_836670.1 CDS S1028 NC_004741.1 1013611 1015776 R residues 1 to 710 of 721 are 92.39 pct identical to residues 1 to 710 of 720 from Escherichia coli K-12 : B0960; hypothetical protein complement(1013611..1015776) Shigella flexneri 2a str. 2457T 1077430 NP_836671.1 CDS yccF NC_004741.1 1015786 1016232 R residues 1 to 148 of 148 are 91.89 pct identical to residues 1 to 148 of 148 from Escherichia coli K-12 : B0961; hypothetical protein complement(1015786..1016232) Shigella flexneri 2a str. 2457T 1077431 NP_836672.1 CDS helD NC_004741.1 1016355 1018409 D catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1016355..1018409 Shigella flexneri 2a str. 2457T 1077432 NP_836673.2 CDS mgsA NC_004741.1 1018441 1018899 R catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase complement(1018441..1018899) Shigella flexneri 2a str. 2457T 1077433 NP_836674.1 CDS S1032 NC_004741.1 1018995 1019657 R residues 1 to 220 of 220 are 100.00 pct identical to residues 1 to 220 of 220 from Escherichia coli K-12 : B0964; hypothetical protein complement(1018995..1019657) Shigella flexneri 2a str. 2457T 1077434 NP_836675.1 CDS S1033 NC_004741.1 1019776 1020243 D residues 1 to 155 of 155 are 99.35 pct identical to residues 10 to 164 of 164 from Escherichia coli K-12 : B0965; hypothetical protein 1019776..1020243 Shigella flexneri 2a str. 2457T 1077435 NP_836676.1 CDS yccV NC_004741.1 1020288 1020656 R residues 1 to 122 of 122 are 100.00 pct identical to residues 1 to 122 of 122 from Escherichia coli K-12 : B0966; hypothetical protein complement(1020288..1020656) Shigella flexneri 2a str. 2457T 1077436 NP_836677.1 CDS S1035 NC_004741.1 1020663 1021766 R residues 1 to 367 of 367 are 97.00 pct identical to residues 1 to 367 of 367 from Escherichia coli K-12 : B0967; oxidoreductase complement(1020663..1021766) Shigella flexneri 2a str. 2457T 1077437 NP_836678.1 CDS S1036 NC_004741.1 1021948 1022226 D residues 1 to 92 of 92 are 97.82 pct identical to residues 1 to 92 of 92 from Escherichia coli K-12 : B0968; hypothetical protein 1021948..1022226 Shigella flexneri 2a str. 2457T 1077438 NP_836679.2 CDS yccK NC_004741.1 1022223 1022552 R transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE complement(1022223..1022552) Shigella flexneri 2a str. 2457T 1077439 NP_836680.1 CDS yccA NC_004741.1 1022643 1023302 R residues 1 to 219 of 219 are 99.54 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B0970; hypothetical protein complement(1022643..1023302) Shigella flexneri 2a str. 2457T 1077440 NP_836681.1 CDS hyaA NC_004741.1 1024022 1025140 D residues 1 to 372 of 372 are 91.12 pct identical to residues 1 to 372 of 372 from Escherichia coli K-12 : B0972; hydrogenase-1 small subunit 1024022..1025140 Shigella flexneri 2a str. 2457T 1077442 NP_836682.1 CDS hyaB NC_004741.1 1025137 1026930 D involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1025137..1026930 Shigella flexneri 2a str. 2457T 1077443 NP_836683.1 CDS hyaC NC_004741.1 1026949 1027656 D residues 1 to 235 of 235 are 99.57 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B0974; hydrogenase 1 b-type cytochrome subunit 1026949..1027656 Shigella flexneri 2a str. 2457T 1077444 NP_836684.1 CDS hyaD NC_004741.1 1027653 1028240 D HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1027653..1028240 Shigella flexneri 2a str. 2457T 1077445 NP_836685.1 CDS hyaE NC_004741.1 1028237 1028635 D involved in processing hydrogenases HyaA and HyaB; hydrogenase-1 operon protein HyaE 1028237..1028635 Shigella flexneri 2a str. 2457T 1077446 NP_836686.1 CDS hyaF NC_004741.1 1028632 1029489 D residues 1 to 285 of 285 are 95.08 pct identical to residues 1 to 285 of 285 from Escherichia coli K-12 : B0977; hydrogenase-1 operon protein hyaF 1028632..1029489 Shigella flexneri 2a str. 2457T 1077447 NP_836687.1 CDS appC NC_004741.1 1029623 1031167 D residues 1 to 514 of 514 are 96.69 pct identical to residues 1 to 514 of 514 from Escherichia coli K-12 : B0978; third cytochrome oxidase, subunit I 1029623..1031167 Shigella flexneri 2a str. 2457T 1077448 NP_836688.1 CDS appB NC_004741.1 1031179 1032315 D residues 1 to 378 of 378 are 91.00 pct identical to residues 1 to 378 of 378 from Escherichia coli K-12 : B0979; third cytochrome oxidase, subunit II 1031179..1032315 Shigella flexneri 2a str. 2457T 1077449 NP_836689.1 CDS appA NC_004741.1 1032499 1033797 D residues 18 to 432 of 432 are 95.18 pct identical to residues 18 to 432 of 432 from Escherichia coli K-12 : B0980; phosphoanhydride phosphorylase 1032499..1033797 Shigella flexneri 2a str. 2457T 1077450 NP_836690.2 CDS etp NC_004741.1 1036098 1036544 R Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase complement(1036098..1036544) Shigella flexneri 2a str. 2457T 1077452 NP_836691.1 CDS yccZ NC_004741.1 1036532 1037671 R residues 1 to 379 of 379 are 100.00 pct identical to residues 1 to 379 of 379 from Escherichia coli K-12 : B0983; involved in exopolysaccharide production; exopolysaccharide export protein complement(1036532..1037671) Shigella flexneri 2a str. 2457T 1077453 NP_836692.1 CDS ymcA NC_004741.1 1037717 1039813 R residues 1 to 698 of 698 are 98.85 pct identical to residues 1 to 698 of 698 from Escherichia coli K-12 : B0984; hypothetical protein complement(1037717..1039813) Shigella flexneri 2a str. 2457T 1077454 NP_836693.1 CDS ymcB NC_004741.1 1039813 1040559 R residues 1 to 248 of 248 are 99.59 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 : B0985; hypothetical protein complement(1039813..1040559) Shigella flexneri 2a str. 2457T 1077455 NP_836694.1 CDS ymcC NC_004741.1 1040556 1041200 R residues 1 to 214 of 214 are 89.71 pct identical to residues 1 to 214 of 214 from Escherichia coli K-12 : B0986; regulator complement(1040556..1041200) Shigella flexneri 2a str. 2457T 1077456 NP_836695.1 CDS ymcD NC_004741.1 1041307 1041630 R residues 1 to 107 of 107 are 28.97 pct identical to residues 1 to 107 of 107 from Escherichia coli K-12 : B0987; hypothetical protein complement(1041307..1041630) Shigella flexneri 2a str. 2457T 1077457 NP_836696.1 CDS cspH NC_004741.1 1042054 1042266 R residues 1 to 70 of 70 are 100.00 pct identical to residues 1 to 70 of 70 from Escherichia coli K-12 : B0989; cold shock-like protein complement(1042054..1042266) Shigella flexneri 2a str. 2457T 1077458 NP_836697.1 CDS S1058 NC_004741.1 1042621 1042896 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1042621..1042896 Shigella flexneri 2a str. 2457T 1077459 NP_836698.1 CDS S1059 NC_004741.1 1042815 1043318 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1042815..1043318 Shigella flexneri 2a str. 2457T 1077460 NP_836699.1 CDS cspG NC_004741.1 1043340 1043540 D residues 2 to 71 of 71 are 97.14 pct identical to residues 1 to 70 of 70 from Escherichia coli K-12 : B0990; cold shock protein CspG 1043340..1043540 Shigella flexneri 2a str. 2457T 1077461 NP_836700.1 CDS ymcE NC_004741.1 1043714 1043944 D residues 1 to 76 of 76 are 96.05 pct identical to residues 1 to 76 of 76 from Escherichia coli K-12 : B0991; cold shock gene 1043714..1043944 Shigella flexneri 2a str. 2457T 1077462 NP_836701.1 CDS yccM NC_004741.1 1044156 1045229 R residues 1 to 357 of 357 are 95.23 pct identical to residues 1 to 357 of 357 from Escherichia coli K-12 : B0992; hypothetical protein complement(1044156..1045229) Shigella flexneri 2a str. 2457T 1077463 NP_836702.1 CDS torT NC_004741.1 1048125 1049153 D periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1048125..1049153 Shigella flexneri 2a str. 2457T 1077465 NP_836703.1 CDS torR NC_004741.1 1049126 1049818 R response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR complement(1049126..1049818) Shigella flexneri 2a str. 2457T 1077466 NP_836704.1 CDS torC NC_004741.1 1049905 1051077 D residues 1 to 390 of 390 are 94.87 pct identical to residues 1 to 390 of 390 from Escherichia coli K-12 : B0996; trimethylamine N-oxide reductase, cytochrome c-type subunit 1049905..1051077 Shigella flexneri 2a str. 2457T 1077467 NP_836705.1 CDS S1069 NC_004741.1 1053820 1054323 R residues 1 to 167 of 167 are 89.22 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(1053820..1054323) Shigella flexneri 2a str. 2457T 1077470 NP_836706.1 CDS S1070 NC_004741.1 1054242 1054517 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1054242..1054517) Shigella flexneri 2a str. 2457T 1078500 NP_836707.1 CDS yccD NC_004741.1 1055083 1055388 R with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM complement(1055083..1055388) Shigella flexneri 2a str. 2457T 1077471 NP_836708.1 CDS cbpA NC_004741.1 1055388 1056308 R functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA complement(1055388..1056308) Shigella flexneri 2a str. 2457T 1077472 NP_836709.1 CDS yccE NC_004741.1 1056569 1057825 D residues 1 to 417 of 418 are 88.00 pct identical to residues 1 to 417 of 418 from Escherichia coli K-12 : B1001; hypothetical protein 1056569..1057825 Shigella flexneri 2a str. 2457T 1077473 NP_836710.1 CDS agp NC_004741.1 1058118 1059359 D residues 1 to 413 of 413 are 98.54 pct identical to residues 1 to 413 of 413 from Escherichia coli K-12 : B1002; glucose-1-phosphatase/inositol phosphatase 1058118..1059359 Shigella flexneri 2a str. 2457T 1077474 NP_836711.1 CDS yccJ NC_004741.1 1059397 1059624 R residues 1 to 75 of 75 are 100.00 pct identical to residues 1 to 75 of 75 from Escherichia coli K-12 : B1003; hypothetical protein complement(1059397..1059624) Shigella flexneri 2a str. 2457T 1076625 NP_836712.1 CDS wrbA NC_004741.1 1059645 1060241 R stationary phase that binds TrpR repressor; TrpR binding protein WrbA complement(1059645..1060241) Shigella flexneri 2a str. 2457T 1077475 NP_836713.1 CDS ycdF NC_004741.1 1060451 1060681 D residues 1 to 76 of 76 are 61.84 pct identical to residues 1 to 76 of 76 from Escherichia coli K-12 : B1005; hypothetical protein 1060451..1060681 Shigella flexneri 2a str. 2457T 1077476 NP_836714.1 CDS ycdG NC_004741.1 1060803 1062197 R residues 1 to 464 of 464 are 92.24 pct identical to residues 1 to 464 of 464 from Escherichia coli K-12 : B1006; transporter complement(1060803..1062197) Shigella flexneri 2a str. 2457T 1077477 NP_836715.1 CDS S1080 NC_004741.1 1062152 1062610 R residues 1 to 152 of 152 are 99.34 pct identical to residues 1 to 152 of 152 from Escherichia coli K-12 : B1007; hypothetical protein complement(1062152..1062610) Shigella flexneri 2a str. 2457T 1077478 NP_836716.1 CDS S1081 NC_004741.1 1062657 1063247 R residues 1 to 196 of 196 are 97.44 pct identical to residues 1 to 196 of 196 from Escherichia coli K-12 : B1008; hypothetical protein complement(1062657..1063247) Shigella flexneri 2a str. 2457T 1077479 NP_836717.1 CDS S1082 NC_004741.1 1063257 1064057 R residues 1 to 266 of 266 are 83.83 pct identical to residues 1 to 266 of 266 from Escherichia coli K-12 : B1009; acetyltransferase complement(1063257..1064057) Shigella flexneri 2a str. 2457T 1077480 NP_836718.1 CDS S1083 NC_004741.1 1064065 1064451 R residues 1 to 128 of 128 are 99.21 pct identical to residues 1 to 128 of 128 from Escherichia coli K-12 : B1010; hypothetical protein complement(1064065..1064451) Shigella flexneri 2a str. 2457T 1077481 NP_836719.1 CDS S1084 NC_004741.1 1064463 1065197 R residues 1 to 244 of 244 are 97.95 pct identical to residues 1 to 244 of 244 from Escherichia coli K-12 : B1011; synthetase complement(1064463..1065197) Shigella flexneri 2a str. 2457T 1077482 NP_836720.1 CDS S1085 NC_004741.1 1065155 1066303 R residues 1 to 382 of 382 are 95.54 pct identical to residues 1 to 382 of 382 from Escherichia coli K-12 : B1012; hypothetical protein complement(1065155..1066303) Shigella flexneri 2a str. 2457T 1077483 NP_836721.1 CDS ycdC NC_004741.1 1066534 1067172 D residues 1 to 212 of 212 are 91.50 pct identical to residues 1 to 212 of 212 from Escherichia coli K-12 : B1013; tet operon regulator 1066534..1067172 Shigella flexneri 2a str. 2457T 1077484 NP_836722.1 CDS S1087 NC_004741.1 1067466 1068653 R residues 1 to 388 of 395 are 97.16 pct identical to residues 1 to 388 of 406 from GenPept : >gb|AAK85176.1| (AF294823) transposase [Shigella sonnei]; IS91 complement(1067466..1068653) Shigella flexneri 2a str. 2457T 1077485 NP_836723.1 CDS S1088 NC_004741.1 1068670 1069017 R residues 1 to 115 of 115 are 89.56 pct identical to residues 1 to 115 of 121 from GenPept : >emb|CAC14584.1| (X17114) ORF 121 [Escherichia coli]; IS91 complement(1068670..1069017) Shigella flexneri 2a str. 2457T 1077486 NP_836724.1 CDS S1089 NC_004741.1 1069073 1069780 D residues 12 to 235 of 235 are 91.96 pct identical to residues 20 to 243 of 243 from Escherichia coli K-12 : B1017; cytochrome 1069073..1069780 Shigella flexneri 2a str. 2457T 1077487 NP_836725.1 CDS ycdO NC_004741.1 1069838 1070965 D residues 1 to 375 of 375 are 95.46 pct identical to residues 1 to 375 of 375 from Escherichia coli K-12 : B1018; hypothetical protein 1069838..1070965 Shigella flexneri 2a str. 2457T 1077488 NP_836726.1 CDS ycdB NC_004741.1 1070971 1072236 D residues 1 to 421 of 421 are 97.87 pct identical to residues 1 to 423 of 423 from Escherichia coli K-12 : B1019; hypothetical protein 1070971..1072236 Shigella flexneri 2a str. 2457T 1077489 NP_836727.1 CDS S1093 NC_004741.1 1073741 1074607 R residues 1 to 288 of 288 are 100.00 pct identical to residues 1 to 288 of 288 from GenPept : >gb|AAL57519.1|AF453441_3 (AF453441) transposase 1 [Escherichia coli]; IS3 orfB complement(1073741..1074607) Shigella flexneri 2a str. 2457T 1077491 NP_836728.1 CDS S1094 NC_004741.1 1074604 1074903 R residues 1 to 99 of 99 are 100.00 pct identical to residues 1 to 99 of 99 from GenPept : >gb|AAL57580.1|AF453442_9 (AF453442) transposase 2 [Escherichia coli]; IS3 orfA complement(1074604..1074903) Shigella flexneri 2a str. 2457T 1077492 NP_836729.1 CDS ycdU NC_004741.1 1075495 1076481 D residues 1 to 328 of 328 are 94.20 pct identical to residues 1 to 328 of 328 from Escherichia coli K-12 : B1029; hypothetical protein 1075495..1076481 Shigella flexneri 2a str. 2457T 1077494 NP_836730.1 CDS ycdX NC_004741.1 1077989 1078726 D residues 1 to 245 of 245 are 87.34 pct identical to residues 1 to 245 of 245 from Escherichia coli K-12 : B1034; hydrolase 1077989..1078726 Shigella flexneri 2a str. 2457T 1077499 NP_836731.1 CDS ycdY NC_004741.1 1078750 1079304 D residues 1 to 184 of 184 are 99.45 pct identical to residues 1 to 184 of 184 from Escherichia coli K-12 : B1035; oxidoreductase component 1078750..1079304 Shigella flexneri 2a str. 2457T 1077500 NP_836732.1 CDS ycdZ NC_004741.1 1079376 1079897 D residues 1 to 173 of 173 are 99.42 pct identical to residues 7 to 179 of 179 from Escherichia coli K-12 : B1036; hypothetical protein 1079376..1079897 Shigella flexneri 2a str. 2457T 1077501 NP_836733.1 CDS csgF NC_004741.1 1080763 1081179 R nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF complement(1080763..1081179) Shigella flexneri 2a str. 2457T 1077503 NP_836734.1 CDS csgE NC_004741.1 1081204 1081593 R chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE complement(1081204..1081593) Shigella flexneri 2a str. 2457T 1077504 NP_836735.1 CDS csgD NC_004741.1 1081598 1082248 R activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD complement(1081598..1082248) Shigella flexneri 2a str. 2457T 1077505 NP_836736.1 CDS csgB NC_004741.1 1083002 1083457 D CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1083002..1083457 Shigella flexneri 2a str. 2457T 1077506 NP_836737.1 CDS S1110 NC_004741.1 1083671 1083973 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 1083671..1083973 Shigella flexneri 2a str. 2457T 1077508 NP_836738.1 CDS S1111 NC_004741.1 1084114 1084752 D residues 1 to 181 of 212 are 88.39 pct identical to residues 36 to 216 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 ORF2 1084114..1084752 Shigella flexneri 2a str. 2457T 1077509 NP_836739.1 CDS csgC NC_004741.1 1085157 1085489 D involved in autoagglutination of curliated cells; not involved in production of curli fibers; autoagglutination protein 1085157..1085489 Shigella flexneri 2a str. 2457T 1077510 NP_836740.1 CDS S1114 NC_004741.1 1085610 1085921 D residues 1 to 103 of 103 are 98.05 pct identical to residues 1 to 103 of 103 from Escherichia coli K-12 : B1044; hypothetical protein 1085610..1085921 Shigella flexneri 2a str. 2457T 1077511 NP_836741.1 CDS S1115 NC_004741.1 1086016 1086549 D residues 1 to 177 of 177 are 99.43 pct identical to residues 1 to 177 of 177 from Escherichia coli K-12 : B1045; hypothetical protein 1086016..1086549 Shigella flexneri 2a str. 2457T 1077512 NP_836742.1 CDS ymdC NC_004741.1 1086491 1087972 D residues 1 to 493 of 493 are 99.79 pct identical to residues 1 to 493 of 493 from Escherichia coli K-12 : B1046; synthase 1086491..1087972 Shigella flexneri 2a str. 2457T 1077513 NP_836743.1 CDS mdoC NC_004741.1 1087980 1089137 R required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein complement(1087980..1089137) Shigella flexneri 2a str. 2457T 1077514 NP_836744.1 CDS mdoG NC_004741.1 1089531 1091066 D involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1089531..1091066 Shigella flexneri 2a str. 2457T 1077515 NP_836745.1 CDS mdoH NC_004741.1 1091059 1093602 D necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1091059..1093602 Shigella flexneri 2a str. 2457T 1077517 NP_836746.1 CDS S1120 NC_004741.1 1094152 1095207 R residues 1 to 351 of 351 are 98.00 pct identical to residues 1 to 351 of 406 from GenPept : >gb|AAK85176.1| (AF294823) transposase [Shigella sonnei]; IS91 orf complement(1094152..1095207) Shigella flexneri 2a str. 2457T 1077518 NP_836747.1 CDS S4816 NC_004741.1 1095207 1095629 R residues 1 to 140 of 140 are 100.00 pct identical to residues 1 to 140 of 140 from NRprotein_Feb03 : >ref|NP_706937.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301] ref|NP_706962.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301] ref|NP_707627.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN42644.1|AE015130_3 orf, conserved hypo; hypothetical protein complement(1095207..1095629) Shigella flexneri 2a str. 2457T 1077519 NP_836748.1 CDS S4815 NC_004741.1 1095591 1096931 D residues 22 to 289 of 446 are 25.09 pct identical to residues 246 to 502 of 1525 from NRprotein_Feb03 : >ref|NP_395347.1| membrane protein [Yersinia pestis] pir||T14961 hypothetical protein Y1044 - Yersinia pestis plasmid pMT1 gb|AAC13170.1| protein HI1514 homolog [Yersinia pestis] gb|AAC82704.1| unknown [Yersinia pestis] emb|CAB55193.1| membrane protein [Yersinia pestis]; hypothetical protein 1095591..1096931 Shigella flexneri 2a str. 2457T 1076637 NP_836749.1 CDS S4817 NC_004741.1 1096928 1097200 D no significant similarities; hypothetical protein 1096928..1097200 Shigella flexneri 2a str. 2457T 1077520 NP_836750.1 CDS S1123 NC_004741.1 1097304 1097924 R residues 1 to 206 of 206 are 99.51 pct identical to residues 1 to 206 of 206 from GenPept : >gb|AAD44736.1|AF141323_7 (AF141323) TnpC [Shigella flexneri]; partial; IS629 orfB complement(1097304..1097924) Shigella flexneri 2a str. 2457T 1077521 NP_836751.1 CDS S1124 NC_004741.1 1098187 1098513 R residues 1 to 108 of 108 are 89.81 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72456.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA complement(1098187..1098513) Shigella flexneri 2a str. 2457T 1077522 NP_836752.1 CDS S1126 NC_004741.1 1098945 1099247 D residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 1098945..1099247 Shigella flexneri 2a str. 2457T 1077523 NP_836753.1 CDS S1127 NC_004741.1 1099436 1100113 D residues 1 to 225 of 225 are 100.00 pct identical to residues 55 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; IS911 orfB 1099436..1100113 Shigella flexneri 2a str. 2457T 1077524 NP_836754.1 CDS S1128 NC_004741.1 1100131 1100553 R no significant similarities; hypothetical protein complement(1100131..1100553) Shigella flexneri 2a str. 2457T 1077525 NP_836755.2 CDS S1129 NC_004741.1 1100686 1101051 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1100686..1101051 Shigella flexneri 2a str. 2457T 1077526 NP_836756.2 CDS S1130 NC_004741.1 1101009 1101914 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1101009..1101914 Shigella flexneri 2a str. 2457T 1077527 NP_836757.1 CDS S1131 NC_004741.1 1102310 1102636 D residues 1 to 108 of 108 are 89.81 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72456.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA 1102310..1102636 Shigella flexneri 2a str. 2457T 1077528 NP_836758.1 CDS S1132 NC_004741.1 1102872 1103519 D residues 1 to 215 of 215 are 99.06 pct identical to residues 1 to 215 of 215 from GenPept : >gb|AAK18507.1|AF348706_196 (AF348706) IS629 orf [Shigella flexneri]; partial; IS629 orfB 1102872..1103519 Shigella flexneri 2a str. 2457T 1077529 NP_836759.1 CDS S1133 NC_004741.1 1103807 1104109 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 1103807..1104109 Shigella flexneri 2a str. 2457T 1077530 NP_836760.1 CDS S1134 NC_004741.1 1104250 1104729 D residues 1 to 144 of 159 are 85.41 pct identical to residues 36 to 179 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS600 orfB 1104250..1104729 Shigella flexneri 2a str. 2457T 1077531 NP_836761.1 CDS S1135 NC_004741.1 1104738 1104962 D residues 1 to 74 of 74 are 98.64 pct identical to residues 73 to 146 of 146 from GenPept : >gb|AAL72524.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS600 orfB 1104738..1104962 Shigella flexneri 2a str. 2457T 1077532 NP_836762.1 CDS S1136 NC_004741.1 1104987 1105919 R residues 1 to 306 of 310 are 43.31 pct identical to residues 1 to 310 of 508 from GenPept : >gb|AAG55968.1|AE005329_12 (AE005329) unknown protein encoded by prophage CP-933X [Escherichia coli O157:H7 EDL933]; hypothetical protein complement(1104987..1105919) Shigella flexneri 2a str. 2457T 1077533 NP_836763.1 CDS htrB NC_004741.1 1106312 1107232 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(1106312..1107232) Shigella flexneri 2a str. 2457T 1077535 NP_836764.1 CDS yceA NC_004741.1 1107457 1108509 D residues 1 to 350 of 350 are 99.71 pct identical to residues 1 to 350 of 350 from Escherichia coli K-12 : B1055; hypothetical protein 1107457..1108509 Shigella flexneri 2a str. 2457T 1077536 NP_836765.1 CDS yceI NC_004741.1 1108551 1109126 R residues 1 to 191 of 191 are 92.67 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B1056; hypothetical protein complement(1108551..1109126) Shigella flexneri 2a str. 2457T 1077537 NP_836766.1 CDS S1141 NC_004741.1 1109130 1109696 R residues 1 to 188 of 188 are 83.51 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 : B1057; cytochrome complement(1109130..1109696) Shigella flexneri 2a str. 2457T 1077538 NP_836767.1 CDS yceO NC_004741.1 1109957 1110070 R residues 1 to 37 of 37 are 100.00 pct identical to residues 10 to 46 of 46 from Escherichia coli K-12 : B1058; hypothetical protein complement(1109957..1110070) Shigella flexneri 2a str. 2457T 1077539 NP_836768.1 CDS solA NC_004741.1 1110118 1111236 R catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase complement(1110118..1111236) Shigella flexneri 2a str. 2457T 1077540 NP_836769.2 CDS bssS NC_004741.1 1111351 1111605 R BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS complement(1111351..1111605) Shigella flexneri 2a str. 2457T 1077541 NP_836770.1 CDS dinI NC_004741.1 1111895 1112140 R residues 1 to 81 of 81 are 100.00 pct identical to residues 1 to 81 of 81 from Escherichia coli K-12 : B1061; DNA damage-inducible protein I complement(1111895..1112140) Shigella flexneri 2a str. 2457T 1077542 NP_836771.1 CDS pyrC NC_004741.1 1112214 1113260 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1112214..1113260) Shigella flexneri 2a str. 2457T 1077543 NP_836772.1 CDS yceB NC_004741.1 1113366 1113926 R residues 1 to 186 of 186 are 100.00 pct identical to residues 1 to 186 of 186 from Escherichia coli K-12 : B1063; hypothetical protein complement(1113366..1113926) Shigella flexneri 2a str. 2457T 1077544 NP_836773.1 CDS grxB NC_004741.1 1114060 1114707 R cofactor involved in the reduction of disulfides; glutaredoxin complement(1114060..1114707) Shigella flexneri 2a str. 2457T 1077545 NP_836774.1 CDS yceL NC_004741.1 1114771 1115979 R Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH complement(1114771..1115979) Shigella flexneri 2a str. 2457T 1077546 NP_836775.1 CDS rimJ NC_004741.1 1116215 1116799 D residues 1 to 194 of 194 are 100.00 pct identical to residues 1 to 194 of 194 from Escherichia coli K-12 : B1066; required for acetylation of N-terminal alanine of 30S ribosomal subunit protein S5; ribosomal-protein-S5-alanine N-acetyltransferase 1116215..1116799 Shigella flexneri 2a str. 2457T 1077547 NP_836776.1 CDS yceH NC_004741.1 1116810 1117457 D residues 1 to 215 of 215 are 98.13 pct identical to residues 1 to 215 of 215 from Escherichia coli K-12 : B1067; hypothetical protein 1116810..1117457 Shigella flexneri 2a str. 2457T 1077548 NP_836777.1 CDS mviM NC_004741.1 1117459 1118292 D residues 1 to 277 of 277 are 94.58 pct identical to residues 1 to 277 of 307 from Escherichia coli K-12 : B1068; virulence factor 1117459..1118292 Shigella flexneri 2a str. 2457T 1077549 NP_836778.1 CDS mviN NC_004741.1 1118492 1120027 D residues 1 to 511 of 511 are 86.88 pct identical to residues 1 to 511 of 511 from Escherichia coli K-12 : B1069; virulence factor 1118492..1120027 Shigella flexneri 2a str. 2457T 1077577 NP_836779.1 CDS flgN NC_004741.1 1120067 1120483 R residues 1 to 138 of 138 are 97.82 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 : B1070; flagella synthesis protein FlgN complement(1120067..1120483) Shigella flexneri 2a str. 2457T 1077550 NP_836780.1 CDS flgM NC_004741.1 1120488 1120781 R regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM complement(1120488..1120781) Shigella flexneri 2a str. 2457T 1077551 NP_836781.1 CDS flgA NC_004741.1 1120857 1121516 R required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA complement(1120857..1121516) Shigella flexneri 2a str. 2457T 1077552 NP_836782.1 CDS flgB NC_004741.1 1121671 1122087 D with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal body rod protein FlgB 1121671..1122087 Shigella flexneri 2a str. 2457T 1077609 NP_836783.1 CDS flgD NC_004741.1 1122506 1123201 D acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1122506..1123201 Shigella flexneri 2a str. 2457T 1077554 NP_836784.1 CDS flgE NC_004741.1 1123226 1124434 D the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1123226..1124434 Shigella flexneri 2a str. 2457T 1077555 NP_836785.1 CDS flgG NC_004741.1 1125343 1126125 D makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1125343..1126125 Shigella flexneri 2a str. 2457T 1077557 NP_836786.1 CDS flgH NC_004741.1 1126178 1126876 D part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1126178..1126876 Shigella flexneri 2a str. 2457T 1077558 NP_836787.1 CDS flgI NC_004741.1 1126888 1127985 D part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 1126888..1127985 Shigella flexneri 2a str. 2457T 1077559 NP_836788.1 CDS flgJ NC_004741.1 1127985 1128926 D Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1127985..1128926 Shigella flexneri 2a str. 2457T 1077560 NP_836789.2 CDS rne NC_004741.1 1131785 1134976 R bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E complement(1131785..1134976) Shigella flexneri 2a str. 2457T 1077565 NP_836790.1 CDS S1169 NC_004741.1 1135057 1135431 D residues 1 to 124 of 124 are 87.09 pct identical to residues 1 to 124 of 124 from Escherichia coli K-12 : B1085; hypothetical protein 1135057..1135431 Shigella flexneri 2a str. 2457T 1077566 NP_836791.1 CDS yceC NC_004741.1 1135549 1136508 D catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1135549..1136508 Shigella flexneri 2a str. 2457T 1077567 NP_836792.2 CDS maf NC_004741.1 1136620 1137204 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(1136620..1137204) Shigella flexneri 2a str. 2457T 1077568 NP_836793.1 CDS yceD NC_004741.1 1137403 1137924 D residues 1 to 173 of 173 are 90.17 pct identical to residues 1 to 173 of 173 from Escherichia coli K-12 : B1088; hypothetical protein 1137403..1137924 Shigella flexneri 2a str. 2457T 1077591 NP_836794.1 CDS rpmF NC_004741.1 1137976 1138149 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1137976..1138149 Shigella flexneri 2a str. 2457T 1077571 NP_836795.2 CDS plsX NC_004741.1 1138230 1139300 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1138230..1139300 Shigella flexneri 2a str. 2457T 1080370 NP_836796.1 CDS fabH NC_004741.1 1139368 1140321 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1139368..1140321 Shigella flexneri 2a str. 2457T 1077576 NP_836797.1 CDS fabD NC_004741.1 1140337 1141266 D residues 1 to 309 of 309 are 93.20 pct identical to residues 1 to 309 of 309 from Escherichia coli K-12 : B1092; acyl carrier protein S-malonyltransferase 1140337..1141266 Shigella flexneri 2a str. 2457T 1080752 NP_836798.1 CDS fabG NC_004741.1 1141279 1142013 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1141279..1142013 Shigella flexneri 2a str. 2457T 1077578 NP_836799.1 CDS acpP NC_004741.1 1142224 1142460 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1142224..1142460 Shigella flexneri 2a str. 2457T 1077579 NP_836800.1 CDS fabF NC_004741.1 1142547 1143788 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 1142547..1143788 Shigella flexneri 2a str. 2457T 1078139 NP_836801.1 CDS pabC NC_004741.1 1143908 1144717 D catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1143908..1144717 Shigella flexneri 2a str. 2457T 1077580 NP_836802.1 CDS yceG NC_004741.1 1144720 1145742 D residues 24 to 340 of 340 are 99.05 pct identical to residues 24 to 340 of 340 from Escherichia coli K-12 : B1097; hypothetical protein 1144720..1145742 Shigella flexneri 2a str. 2457T 1077581 NP_836803.1 CDS tmk NC_004741.1 1145732 1146373 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1145732..1146373 Shigella flexneri 2a str. 2457T 1077583 NP_836804.1 CDS holB NC_004741.1 1146370 1147374 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1146370..1147374 Shigella flexneri 2a str. 2457T 1077375 NP_836805.1 CDS ycfH NC_004741.1 1147385 1148182 D residues 1 to 265 of 265 are 93.58 pct identical to residues 1 to 265 of 265 from Escherichia coli K-12 : B1100; metallodependent hydrolase 1147385..1148182 Shigella flexneri 2a str. 2457T 1077584 NP_836806.1 CDS ptsG NC_004741.1 1148477 1149910 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; glucose-specific PTS system IIBC components 1148477..1149910 Shigella flexneri 2a str. 2457T 1080692 NP_836807.1 CDS ycfF NC_004741.1 1152494 1152853 D residues 1 to 119 of 119 are 100.00 pct identical to residues 1 to 119 of 119 from Escherichia coli K-12 : B1103; purine nucleoside phosphoramidase 1152494..1152853 Shigella flexneri 2a str. 2457T 1077589 NP_836808.1 CDS ycfL NC_004741.1 1152856 1153233 D residues 1 to 125 of 125 are 90.39 pct identical to residues 1 to 125 of 125 from Escherichia coli K-12 : B1104; hypothetical protein 1152856..1153233 Shigella flexneri 2a str. 2457T 1078458 NP_836809.1 CDS ycfM NC_004741.1 1153248 1153889 D residues 1 to 213 of 213 are 82.62 pct identical to residues 1 to 213 of 213 from Escherichia coli K-12 : B1105; hypothetical protein 1153248..1153889 Shigella flexneri 2a str. 2457T 1077590 NP_836810.1 CDS thiK NC_004741.1 1153870 1154694 D catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1153870..1154694 Shigella flexneri 2a str. 2457T 1077594 NP_836811.1 CDS ycfO NC_004741.1 1154705 1155730 D hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1154705..1155730 Shigella flexneri 2a str. 2457T 1077595 NP_836812.1 CDS ycfP NC_004741.1 1155753 1156295 D residues 1 to 180 of 180 are 100.00 pct identical to residues 20 to 199 of 199 from Escherichia coli K-12 : B1108; hypothetical protein 1155753..1156295 Shigella flexneri 2a str. 2457T 1077610 NP_836813.1 CDS ndh NC_004741.1 1156703 1158007 D residues 1 to 434 of 434 are 96.54 pct identical to residues 1 to 434 of 434 from Escherichia coli K-12 : B1109; respiratory NADH dehydrogenase 1156703..1158007 Shigella flexneri 2a str. 2457T 1077597 NP_836814.1 CDS ycfJ NC_004741.1 1158234 1158773 D residues 1 to 179 of 179 are 89.94 pct identical to residues 1 to 179 of 179 from Escherichia coli K-12 : B1110; hypothetical protein 1158234..1158773 Shigella flexneri 2a str. 2457T 1077599 NP_836815.1 CDS ycfQ NC_004741.1 1158835 1159545 R residues 1 to 236 of 236 are 99.57 pct identical to residues 1 to 236 of 236 from Escherichia coli K-12 : B1111; hypothetical protein complement(1158835..1159545) Shigella flexneri 2a str. 2457T 1076963 NP_836816.1 CDS ycfR NC_004741.1 1159752 1159964 D residues 1 to 70 of 70 are 98.57 pct identical to residues 16 to 85 of 85 from Escherichia coli K-12 : B1112; hypothetical protein 1159752..1159964 Shigella flexneri 2a str. 2457T 1077600 NP_836817.1 CDS ycfS NC_004741.1 1160047 1161009 R residues 1 to 320 of 320 are 93.12 pct identical to residues 1 to 320 of 320 from Escherichia coli K-12 : B1113; hypothetical protein complement(1160047..1161009) Shigella flexneri 2a str. 2457T 1080746 NP_836818.1 CDS mfd NC_004741.1 1161152 1164598 R residues 1 to 1148 of 1148 are 98.25 pct identical to residues 1 to 1148 of 1148 from Escherichia coli K-12 : B1114; mutation frequency decline; transcription-repair coupling factor complement(1161152..1164598) Shigella flexneri 2a str. 2457T 1077601 NP_836819.1 CDS ycfT NC_004741.1 1164726 1165799 R residues 1 to 357 of 357 are 90.75 pct identical to residues 1 to 357 of 357 from Escherichia coli K-12 : B1115; hypothetical protein complement(1164726..1165799) Shigella flexneri 2a str. 2457T 1077604 NP_836820.1 CDS ycfU NC_004741.1 1166061 1167260 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1166061..1167260 Shigella flexneri 2a str. 2457T 1077603 NP_836821.1 CDS lolD NC_004741.1 1167253 1167954 D outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1167253..1167954 Shigella flexneri 2a str. 2457T 1077592 NP_836822.1 CDS ycfW NC_004741.1 1167954 1169198 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1167954..1169198 Shigella flexneri 2a str. 2457T 1077606 NP_836823.1 CDS ycfX NC_004741.1 1169227 1170138 D catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1169227..1170138 Shigella flexneri 2a str. 2457T 1076442 NP_836824.1 CDS cobB NC_004741.1 1170154 1170975 D Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1170154..1170975 Shigella flexneri 2a str. 2457T 1077607 NP_836825.1 CDS potD NC_004741.1 1171131 1172177 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter substrate-binding protein complement(1171131..1172177) Shigella flexneri 2a str. 2457T 1080984 NP_836826.1 CDS potC NC_004741.1 1172174 1172968 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter complement(1172174..1172968) Shigella flexneri 2a str. 2457T 1077608 NP_836827.2 CDS potB NC_004741.1 1172965 1173822 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter complement(1172965..1173822) Shigella flexneri 2a str. 2457T 1077602 NP_836828.1 CDS potA NC_004741.1 1173806 1174942 R functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase complement(1173806..1174942) Shigella flexneri 2a str. 2457T 1077612 NP_836829.1 CDS pepT NC_004741.1 1175192 1176418 D catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1175192..1176418 Shigella flexneri 2a str. 2457T 1077613 NP_836830.1 CDS ycfD NC_004741.1 1176467 1177597 R residues 1 to 376 of 376 are 95.21 pct identical to residues 1 to 376 of 376 from Escherichia coli K-12 : B1128; hypothetical protein complement(1176467..1177597) Shigella flexneri 2a str. 2457T 1077598 NP_836831.1 CDS S1211 NC_004741.1 1177837 1179066 D residues 1 to 409 of 409 are 100.00 pct identical to residues 8 to 416 of 416 from GenPept : >gb|AAG55933.1|AE005327_3 (AE005327) integrase of prophage CP-933C [Escherichia coli O157:H7 EDL933]; integrase of prophage CP-933C 1177837..1179066 Shigella flexneri 2a str. 2457T 1077614 NP_836832.1 CDS S1212 NC_004741.1 1180340 1180642 D residues 35 to 99 of 100 are 95.38 pct identical to residues 1 to 65 of 65 from GenPept : >dbj|BAB35000.1| (AP002555) Icd-like protein [Escherichia coli O157:H7]; hypothetical protein 1180340..1180642 Shigella flexneri 2a str. 2457T 1078340 NP_836833.1 CDS S1214 NC_004741.1 1181307 1181606 D residues 1 to 99 of 99 are 87.87 pct identical to residues 1 to 99 of 99 from GenPept : >dbj|BAB35004.1| (AP002555) hypothetical protein [Escherichia coli O157:H7]; hypothetical protein 1181307..1181606 Shigella flexneri 2a str. 2457T 1077615 NP_836834.1 CDS S1215 NC_004741.1 1181603 1183351 D residues 142 to 559 of 582 are 49.28 pct identical to residues 309 to 725 of 763 from GenPept : >emb|CAC89726.1| (AJ414145) primase [Yersinia pestis]; bacteriophage P4 DNA primase 1181603..1183351 Shigella flexneri 2a str. 2457T 1077616 NP_836835.1 CDS S1216 NC_004741.1 1183718 1183918 D residues 1 to 66 of 66 are 71.21 pct identical to residues 18 to 83 of 83 from GenPept : >gb|AAG55941.1|AE005327_11 (AE005327) unknown protein encoded by prophage CP-933C [Escherichia coli O157:H7 EDL933]; hypothetical protein 1183718..1183918 Shigella flexneri 2a str. 2457T 1077617 NP_836836.1 CDS S1217 NC_004741.1 1183915 1184220 D no significant similarities; hypothetical protein 1183915..1184220 Shigella flexneri 2a str. 2457T 1077618 NP_836837.1 CDS S1218 NC_004741.1 1184230 1184391 D no significant similarities; hypothetical protein 1184230..1184391 Shigella flexneri 2a str. 2457T 1077619 NP_836838.1 CDS S1219 NC_004741.1 1184533 1184757 D residues 1 to 74 of 74 are 94.59 pct identical to residues 27 to 100 of 100 from GenPept : >gb|AAG55943.1|AE005328_1 (AE005328) unknown protein encoded by prophage CP-933C [Escherichia coli O157:H7 EDL933]; hypothetical protein 1184533..1184757 Shigella flexneri 2a str. 2457T 1077620 NP_836839.1 CDS S1222 NC_004741.1 1186255 1186827 D residues 1 to 190 of 190 are 97.89 pct identical to residues 1 to 190 of 190 from GenPept : >gb|AAG55945.1|AE005328_3 (AE005328) head maturation protease of prophage CP-933C [Escherichia coli O157:H7 EDL933]; head maturation protease of prophage CP-933C 1186255..1186827 Shigella flexneri 2a str. 2457T 1077622 NP_836840.1 CDS S1223 NC_004741.1 1186865 1187992 D residues 1 to 375 of 375 are 97.60 pct identical to residues 13 to 387 of 403 from GenPept : >dbj|BAB35015.1| (AP002555) head portal protein [Escherichia coli O157:H7]; head portal protein 1186865..1187992 Shigella flexneri 2a str. 2457T 1077623 NP_836841.1 CDS S1224 NC_004741.1 1188037 1188375 D residues 1 to 112 of 112 are 96.42 pct identical to residues 1 to 112 of 112 from GenPept : >dbj|BAB35016.1| (AP002555) head-tail adaptor [Escherichia coli O157:H7]; head-tail adaptor 1188037..1188375 Shigella flexneri 2a str. 2457T 1077624 NP_836842.1 CDS S1225 NC_004741.1 1188372 1188668 D residues 1 to 98 of 98 are 96.93 pct identical to residues 1 to 98 of 98 from GenPept : >gb|AAG55948.1|AE005328_6 (AE005328) unknown protein encoded by prophage CP-933C [Escherichia coli O157:H7 EDL933]; hypothetical protein 1188372..1188668 Shigella flexneri 2a str. 2457T 1077956 NP_836843.1 CDS S1226 NC_004741.1 1188896 1189108 D residues 1 to 70 of 70 are 71.42 pct identical to residues 60 to 129 of 129 from GenPept : >gb|AAG55949.1|AE005328_7 (AE005328) holin protein of prophage CP-933C [Escherichia coli O157:H7 EDL933]; holin protein of prophage CP-933C 1188896..1189108 Shigella flexneri 2a str. 2457T 1077627 NP_836844.1 CDS S1227 NC_004741.1 1189345 1189656 D residues 1 to 91 of 103 are 98.90 pct identical to residues 16 to 106 of 118 from GenPept : >gb|AAG55950.1|AE005328_8 (AE005328) unknown protein encoded by prophage CP-933C [Escherichia coli O157:H7 EDL933]; hypothetical protein 1189345..1189656 Shigella flexneri 2a str. 2457T 1077628 NP_836845.1 CDS S1228 NC_004741.1 1189823 1191301 D residues 1 to 492 of 492 are 91.46 pct identical to residues 18 to 509 of 509 from GenPept : >gb|AAG55951.1|AE005328_9 (AE005328) terminase of prophage CP-933C [Escherichia coli O157:H7 EDL933]; terminase of prophage CP-933C 1189823..1191301 Shigella flexneri 2a str. 2457T 1077226 NP_836846.1 CDS S1229 NC_004741.1 1191315 1191596 D residues 1 to 93 of 93 are 93.54 pct identical to residues 1 to 93 of 93 from GenPept : >gb|AAG55952.1|AE005328_10 (AE005328) unknown protein encoded by prophage CP-933C [Escherichia coli O157:H7 EDL933]; hypothetical protein 1191315..1191596 Shigella flexneri 2a str. 2457T 1077629 NP_836847.1 CDS phoQ NC_004741.1 1192393 1193853 R residues 1 to 486 of 486 are 93.00 pct identical to residues 1 to 486 of 486 from Escherichia coli K-12 : B1129; sensor protein PhoQ complement(1192393..1193853) Shigella flexneri 2a str. 2457T 1080919 NP_836848.1 CDS phoP NC_004741.1 1193853 1194524 R response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP complement(1193853..1194524) Shigella flexneri 2a str. 2457T 1077630 NP_836849.1 CDS purB NC_004741.1 1194693 1196063 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(1194693..1196063) Shigella flexneri 2a str. 2457T 1077636 NP_836850.1 CDS ycfC NC_004741.1 1196067 1196708 R HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein complement(1196067..1196708) Shigella flexneri 2a str. 2457T 1077631 NP_836851.2 CDS mnmA NC_004741.1 1196744 1197850 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(1196744..1197850) Shigella flexneri 2a str. 2457T 1077645 NP_836852.1 CDS S1236 NC_004741.1 1197904 1198365 R residues 1 to 153 of 153 are 100.00 pct identical to residues 1 to 153 of 153 from Escherichia coli K-12 : B1134; phosphohydrolase complement(1197904..1198365) Shigella flexneri 2a str. 2457T 1077632 NP_836853.1 CDS ymfC NC_004741.1 1198375 1198998 R catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E complement(1198375..1198998) Shigella flexneri 2a str. 2457T 1077658 NP_836854.1 CDS icdA NC_004741.1 1199200 1200450 D Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1199200..1200450 Shigella flexneri 2a str. 2457T 1077633 NP_836855.1 CDS S1239 NC_004741.1 1200557 1201060 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS1 orfB complement(1200557..1201060) Shigella flexneri 2a str. 2457T 1079276 NP_836856.1 CDS S1240 NC_004741.1 1200979 1201254 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1200979..1201254) Shigella flexneri 2a str. 2457T 1077637 NP_836857.1 CDS S1241 NC_004741.1 1201348 1202871 D residues 1 to 507 of 507 are 98.61 pct identical to residues 1 to 507 of 507 from NRprotein_Feb2003 : >sp|P75995|YCGG_ECOLI Hypothetical protein ycgG; hypothetical protein 1201348..1202871 Shigella flexneri 2a str. 2457T 1079348 NP_836858.1 CDS S1242 NC_004741.1 1203948 1206269 D residues 431 to 749 of 773 are 96.86 pct identical to residues 5 to 323 of 338 from NRprotein_Feb2003 : >ref|NP_415688.1| part of ATP-binding component of a transport system [Escherichia coli K12] pir||G64862 hypothetical protein b1170 - Escherichia coli (strain K-12) gb|AAC74254.1| part of ATP-binding component of a transport system [Escherichia coli K12]; hypothetical protein 1203948..1206269 Shigella flexneri 2a str. 2457T 1077638 NP_836859.1 CDS S1244 NC_004741.1 1206326 1206661 R residues 1 to 111 of 111 are 100.00 pct identical to residues 1 to 111 of 111 from Escherichia coli K-12 : B1171; hypothetical protein complement(1206326..1206661) Shigella flexneri 2a str. 2457T 1080946 NP_836860.1 CDS S1245 NC_004741.1 1206665 1206949 R residues 1 to 94 of 94 are 35.10 pct identical to residues 1 to 94 of 94 from Escherichia coli K-12 : B1172; hypothetical protein complement(1206665..1206949) Shigella flexneri 2a str. 2457T 1077639 NP_836861.1 CDS S1246 NC_004741.1 1207717 1207929 D residues 1 to 70 of 70 are 94.28 pct identical to residues 1 to 70 of 70 from Escherichia coli K-12 : B1173; hypothetical protein 1207717..1207929 Shigella flexneri 2a str. 2457T 1080909 NP_836862.1 CDS minE NC_004741.1 1208301 1208567 R works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE complement(1208301..1208567) Shigella flexneri 2a str. 2457T 1077640 NP_836863.1 CDS minD NC_004741.1 1208571 1209383 R ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD complement(1208571..1209383) Shigella flexneri 2a str. 2457T 1077641 NP_836864.1 CDS minC NC_004741.1 1209407 1210102 R blocks the formation of polar Z-ring septums; septum formation inhibitor complement(1209407..1210102) Shigella flexneri 2a str. 2457T 1077642 NP_836865.2 CDS S1251 NC_004741.1 1210825 1211730 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(1210825..1211730) Shigella flexneri 2a str. 2457T 1077644 NP_836866.1 CDS S1253 NC_004741.1 1212776 1213075 D residues 1 to 99 of 99 are 100.00 pct identical to residues 1 to 99 of 99 from GenPept : >gb|AAL57580.1|AF453442_9 (AF453442) transposase 2 [Escherichia coli]; IS3 orfA 1212776..1213075 Shigella flexneri 2a str. 2457T 1077647 NP_836867.1 CDS S1254 NC_004741.1 1213072 1213926 D residues 1 to 284 of 284 are 100.00 pct identical to residues 1 to 284 of 288 from GenPept : >gb|AAL57581.1|AF453442_10 (AF453442) transposase 1 [Escherichia coli]; IS3 orfB 1213072..1213926 Shigella flexneri 2a str. 2457T 1077646 NP_836868.1 CDS ycgL NC_004741.1 1214284 1214610 D residues 1 to 108 of 108 are 98.14 pct identical to residues 1 to 108 of 108 from Escherichia coli K-12 : B1179; hypothetical protein 1214284..1214610 Shigella flexneri 2a str. 2457T 1077648 NP_836869.1 CDS S1257 NC_004741.1 1214682 1215341 D residues 1 to 219 of 219 are 99.08 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B1180; hypothetical protein 1214682..1215341 Shigella flexneri 2a str. 2457T 1077418 NP_836870.2 CDS ycgN NC_004741.1 1215433 1215879 D residues 1 to 153 of 153 are 100.00 pct identical to residues 6 to 158 of 158 from Escherichia coli K-12 : B1181; hypothetical protein 1215433..1215879 Shigella flexneri 2a str. 2457T 1077650 NP_836871.1 CDS umuD NC_004741.1 1217359 1217778 D binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1217359..1217778 Shigella flexneri 2a str. 2457T 1077651 NP_836872.1 CDS umuC NC_004741.1 1217778 1219046 D binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1217778..1219046 Shigella flexneri 2a str. 2457T 1080938 NP_836873.1 CDS dsbB NC_004741.1 1219092 1219622 R disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B complement(1219092..1219622) Shigella flexneri 2a str. 2457T 1077653 NP_836874.1 CDS nhaB NC_004741.1 1219768 1221309 R involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter complement(1219768..1221309) Shigella flexneri 2a str. 2457T 1079461 NP_836875.1 CDS fadR NC_004741.1 1221530 1222249 D Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1221530..1222249 Shigella flexneri 2a str. 2457T 1077654 NP_836876.1 CDS ycgB NC_004741.1 1222301 1223833 R residues 1 to 510 of 510 are 99.60 pct identical to residues 1 to 510 of 510 from Escherichia coli K-12 : B1188; SpoVR family protein complement(1222301..1223833) Shigella flexneri 2a str. 2457T 1077656 NP_836877.1 CDS dadA NC_004741.1 1224163 1225461 D catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1224163..1225461 Shigella flexneri 2a str. 2457T 1076627 NP_836878.1 CDS dadX NC_004741.1 1225471 1226541 D catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1225471..1226541 Shigella flexneri 2a str. 2457T 1076629 NP_836879.1 CDS ipaH_3 NC_004741.1 1227396 1228004 R residues 116 to 190 of 202 are 42.66 pct identical to residues 42 to 114 of 565 from GenPept : >gb|AAL72346.1| (AF386526) IpaH7.8 [Shigella flexneri 2a]; invasion plasmid antigen fragment complement(1227396..1228004) Shigella flexneri 2a str. 2457T 1077657 NP_836880.2 CDS S1269 NC_004741.1 1228731 1230467 R the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter complement(1228731..1230467) Shigella flexneri 2a str. 2457T 1077669 NP_836881.1 CDS ldcA NC_004741.1 1230562 1231476 R catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A complement(1230562..1231476) Shigella flexneri 2a str. 2457T 1077659 NP_836882.1 CDS mltE NC_004741.1 1231462 1232187 D residues 1 to 241 of 241 are 99.58 pct identical to residues 1 to 241 of 241 from Escherichia coli K-12 : B1193; murein transglycosylase E 1231462..1232187 Shigella flexneri 2a str. 2457T 1080910 NP_836883.1 CDS ycgR NC_004741.1 1232189 1232923 R residues 1 to 244 of 244 are 99.18 pct identical to residues 1 to 244 of 244 from Escherichia coli K-12 : B1194; hypothetical protein complement(1232189..1232923) Shigella flexneri 2a str. 2457T 1077660 NP_836884.1 CDS ymgE NC_004741.1 1233124 1233378 D residues 1 to 84 of 84 are 80.95 pct identical to residues 1 to 84 of 84 from Escherichia coli K-12 : B1195; hypothetical protein 1233124..1233378 Shigella flexneri 2a str. 2457T 1077696 NP_836885.1 CDS modD NC_004741.1 1235408 1236262 R involved in molybdenum transport; molybdenum transport protein ModD complement(1235408..1236262) Shigella flexneri 2a str. 2457T 1077649 NP_836886.1 CDS S1277 NC_004741.1 1236262 1237071 R residues 1 to 269 of 269 are 94.79 pct identical to residues 1 to 269 of 270 from GenPept : >gb|AAC61711.1| (AF081283) Orf2 [Escherichia coli]; hypothetical protein complement(1236262..1237071) Shigella flexneri 2a str. 2457T 1077663 NP_836887.1 CDS S1278 NC_004741.1 1237081 1237839 R residues 1 to 251 of 252 are 98.40 pct identical to residues 1 to 251 of 252 from GenPept : >gb|AAG56052.1|AE005337_2 (AE005337) iron compound ABC transporter ATP-binding protein [Escherichia coli O157:H7 EDL933]; ferric enterobactin transport ATP-binding protein complement(1237081..1237839) Shigella flexneri 2a str. 2457T 1079462 NP_836888.1 CDS S1279 NC_004741.1 1237836 1238816 R residues 1 to 314 of 326 are 87.89 pct identical to residues 1 to 314 of 326 from GenPept : >gb|AAG56053.1|AE005337_3 (AE005337) iron compound ABC transporter permease [Escherichia coli O157:H7 EDL933]; iron compound ABC transporter permease complement(1237836..1238816) Shigella flexneri 2a str. 2457T 1077664 NP_836889.1 CDS S1280 NC_004741.1 1238816 1239838 R residues 1 to 340 of 340 are 87.05 pct identical to residues 1 to 340 of 340 from GenPept : >gb|AAG56054.1|AE005337_4 (AE005337) Z1966 gene product [Escherichia coli O157:H7 EDL933]; ABC transporter ATP-binding protein complement(1238816..1239838) Shigella flexneri 2a str. 2457T 1077718 NP_836890.1 CDS S1281 NC_004741.1 1240551 1241054 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(1240551..1241054) Shigella flexneri 2a str. 2457T 1078216 NP_836891.1 CDS S1282 NC_004741.1 1240973 1241248 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1240973..1241248) Shigella flexneri 2a str. 2457T 1077665 NP_836892.1 CDS treA NC_004741.1 1242200 1243897 R periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase complement(1242200..1243897) Shigella flexneri 2a str. 2457T 1077671 NP_836893.1 CDS ycgC NC_004741.1 1244217 1245635 R phosphotransferaese subunit; phosphorylates dihydroxyacetone; dihydroxyacetone kinase subunit M complement(1244217..1245635) Shigella flexneri 2a str. 2457T 1079261 NP_836894.1 CDS S1286 NC_004741.1 1245646 1246278 R with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase ADP-binding subunit complement(1245646..1246278) Shigella flexneri 2a str. 2457T 1077672 NP_836895.1 CDS S1287 NC_004741.1 1246289 1247389 R with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK complement(1246289..1247389) Shigella flexneri 2a str. 2457T 1078397 NP_836896.1 CDS S1288 NC_004741.1 1247578 1249506 D Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1247578..1249506 Shigella flexneri 2a str. 2457T 1077673 NP_836897.1 CDS S1289 NC_004741.1 1249606 1252473 R residues 1 to 955 of 955 are 88.58 pct identical to residues 1 to 955 of 955 from Escherichia coli K-12 : B1202; adhesion and penetration protein complement(1249606..1252473) Shigella flexneri 2a str. 2457T 1077662 NP_836898.1 CDS ychF NC_004741.1 1253317 1254408 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(1253317..1254408) Shigella flexneri 2a str. 2457T 1077675 NP_836899.1 CDS pth NC_004741.1 1254525 1255109 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(1254525..1255109) Shigella flexneri 2a str. 2457T 1077683 NP_836900.1 CDS ychH NC_004741.1 1255387 1255665 D YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1255387..1255665 Shigella flexneri 2a str. 2457T 1077670 NP_836901.1 CDS ychM NC_004741.1 1255720 1257372 R role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM complement(1255720..1257372) Shigella flexneri 2a str. 2457T 1077676 NP_836902.1 CDS prsA NC_004741.1 1257524 1258471 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1257524..1258471) Shigella flexneri 2a str. 2457T 1077605 NP_836903.1 CDS ipk NC_004741.1 1258622 1259473 R An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(1258622..1259473) Shigella flexneri 2a str. 2457T 1077678 NP_836904.1 CDS lolB NC_004741.1 1259473 1260096 R Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB complement(1259473..1260096) Shigella flexneri 2a str. 2457T 1076727 NP_836905.1 CDS hemA NC_004741.1 1260310 1261566 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1260310..1261566 Shigella flexneri 2a str. 2457T 1077679 NP_836906.1 CDS prfA NC_004741.1 1261608 1262690 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1261608..1262690 Shigella flexneri 2a str. 2457T 1079483 NP_836907.1 CDS hemK NC_004741.1 1262690 1263523 D HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1262690..1263523 Shigella flexneri 2a str. 2457T 1077680 NP_836908.1 CDS S1300 NC_004741.1 1263520 1263912 D residues 1 to 130 of 130 are 99.23 pct identical to residues 1 to 130 of 130 from Escherichia coli K-12 : B1213; transcriptional regulator 1263520..1263912 Shigella flexneri 2a str. 2457T 1077708 NP_836909.1 CDS ychA NC_004741.1 1263916 1264725 D residues 1 to 269 of 269 are 92.93 pct identical to residues 1 to 269 of 269 from Escherichia coli K-12 : B1214; transcriptional regulator 1263916..1264725 Shigella flexneri 2a str. 2457T 1077681 NP_836910.1 CDS kdsA NC_004741.1 1264761 1265615 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1264761..1265615 Shigella flexneri 2a str. 2457T 1077667 NP_836911.1 CDS chaA NC_004741.1 1266276 1267376 R residues 1 to 366 of 366 are 77.86 pct identical to residues 1 to 366 of 366 from Escherichia coli K-12 : B1216; calcium/sodium:proton antiporter complement(1266276..1267376) Shigella flexneri 2a str. 2457T 1077684 NP_836912.1 CDS chaB NC_004741.1 1267646 1267876 D in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1267646..1267876 Shigella flexneri 2a str. 2457T 1080391 NP_836913.1 CDS chaC NC_004741.1 1268013 1268729 D residues 1 to 238 of 238 are 94.53 pct identical to residues 1 to 238 of 238 from Escherichia coli K-12 : B1218; cation transport regulator 1268013..1268729 Shigella flexneri 2a str. 2457T 1078215 NP_836914.1 CDS ychN NC_004741.1 1268773 1269126 R residues 1 to 117 of 117 are 100.00 pct identical to residues 1 to 117 of 117 from Escherichia coli K-12 : B1219; hypothetical protein complement(1268773..1269126) Shigella flexneri 2a str. 2457T 1077685 NP_836915.1 CDS ychP NC_004741.1 1269452 1270705 D residues 1 to 417 of 417 are 95.68 pct identical to residues 1 to 417 of 417 from Escherichia coli K-12 : B1220; hypothetical protein 1269452..1270705 Shigella flexneri 2a str. 2457T 1077677 NP_836916.1 CDS narL NC_004741.1 1270706 1271356 R two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL complement(1270706..1271356) Shigella flexneri 2a str. 2457T 1077686 NP_836917.1 CDS narX NC_004741.1 1271349 1273145 R residues 1 to 598 of 598 are 98.32 pct identical to residues 1 to 598 of 598 from Escherichia coli K-12 : B1222; nitrate/nitrite sensor protein NarX complement(1271349..1273145) Shigella flexneri 2a str. 2457T 1077689 NP_836918.1 CDS narK NC_004741.1 1273484 1274875 D residues 1 to 463 of 463 are 80.99 pct identical to residues 1 to 463 of 463 from Escherichia coli K-12 : B1223; nitrate transport protein nark 1273484..1274875 Shigella flexneri 2a str. 2457T 1077701 NP_836919.1 CDS narG NC_004741.1 1275268 1279011 D residues 1 to 1247 of 1247 are 99.83 pct identical to residues 1 to 1247 of 1247 from Escherichia coli K-12 : B1224; nitrate reductase 1 alpha subunit 1275268..1279011 Shigella flexneri 2a str. 2457T 1077690 NP_836920.1 CDS narH NC_004741.1 1279008 1280546 D residues 1 to 512 of 512 are 100.00 pct identical to residues 1 to 512 of 512 from Escherichia coli K-12 : B1225; nitrate reductase 1, beta subunit 1279008..1280546 Shigella flexneri 2a str. 2457T 1077691 NP_836921.1 CDS narJ NC_004741.1 1280543 1281253 D residues 1 to 236 of 236 are 97.88 pct identical to residues 1 to 236 of 236 from Escherichia coli K-12 : B1226; nitrate reductase 1, delta subunit 1280543..1281253 Shigella flexneri 2a str. 2457T 1076618 NP_836922.1 CDS narI NC_004741.1 1281253 1281930 D residues 1 to 225 of 225 are 93.77 pct identical to residues 1 to 225 of 225 from Escherichia coli K-12 : B1227; nitrate reductase 1, cytochrome b(NR), gamma subunit 1281253..1281930 Shigella flexneri 2a str. 2457T 1077693 NP_836923.1 CDS purU NC_004741.1 1282714 1283556 R produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase complement(1282714..1283556) Shigella flexneri 2a str. 2457T 1079475 NP_836924.2 CDS ychJ NC_004741.1 1283606 1284064 R residues 1 to 104 of 119 are 99.03 pct identical to residues 34 to 137 of 152 from Escherichia coli K-12 : B1233; hypothetical protein complement(1283606..1284064) Shigella flexneri 2a str. 2457T 1077695 NP_836925.1 CDS ychK NC_004741.1 1284177 1285082 D residues 1 to 301 of 301 are 96.01 pct identical to residues 14 to 314 of 314 from Escherichia coli K-12 : B1234; hypothetical protein 1284177..1285082 Shigella flexneri 2a str. 2457T 1077687 NP_836926.1 CDS hnr NC_004741.1 1285174 1286187 D residues 1 to 337 of 337 are 92.28 pct identical to residues 1 to 337 of 337 from Escherichia coli K-12 : B1235; response regulator of RpoS 1285174..1286187 Shigella flexneri 2a str. 2457T 1077698 NP_836927.1 CDS galU NC_004741.1 1286389 1287297 D together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalU 1286389..1287297 Shigella flexneri 2a str. 2457T 1077674 NP_836928.1 CDS hns NC_004741.1 1287441 1287854 R residues 1 to 137 of 137 are 72.99 pct identical to residues 1 to 137 of 137 from Escherichia coli K-12 : B1237; global DNA-binding transcriptional dual regulator H-NS complement(1287441..1287854) Shigella flexneri 2a str. 2457T 1077699 NP_836929.1 CDS tdk NC_004741.1 1288459 1289076 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1288459..1289076 Shigella flexneri 2a str. 2457T 1077655 NP_836930.1 CDS S1325 NC_004741.1 1289362 1290690 R residues 1 to 442 of 442 are 99.32 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf complement(1289362..1290690) Shigella flexneri 2a str. 2457T 1077736 NP_836931.1 CDS adhE NC_004741.1 1290816 1293491 R residues 1 to 872 of 891 are 91.74 pct identical to residues 1 to 872 of 891 from Escherichia coli K-12 : B1241; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1290816..1293491) Shigella flexneri 2a str. 2457T 1077703 NP_836932.1 CDS ychE NC_004741.1 1293968 1294615 D residues 1 to 215 of 215 are 99.53 pct identical to residues 1 to 215 of 215 from Escherichia coli K-12 : B1242; hypothetical protein 1293968..1294615 Shigella flexneri 2a str. 2457T 1077995 NP_836933.1 CDS S1328 NC_004741.1 1294982 1295485 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(1294982..1295485) Shigella flexneri 2a str. 2457T 1077704 NP_836934.1 CDS S1329 NC_004741.1 1295404 1295679 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1295404..1295679) Shigella flexneri 2a str. 2457T 1077705 NP_836935.1 CDS oppA NC_004741.1 1296130 1297761 D residues 1 to 543 of 543 are 95.76 pct identical to residues 1 to 543 of 543 from Escherichia coli K-12 : B1243; periplasmic oligopeptide binding protein 1296130..1297761 Shigella flexneri 2a str. 2457T 1077724 NP_836936.1 CDS oppB NC_004741.1 1297847 1298767 D residues 1 to 306 of 306 are 100.00 pct identical to residues 1 to 306 of 306 from Escherichia coli K-12 : B1244; oligopeptide transporter permease 1297847..1298767 Shigella flexneri 2a str. 2457T 1077706 NP_836937.1 CDS oppC NC_004741.1 1298782 1299690 D residues 1 to 302 of 302 are 81.45 pct identical to residues 1 to 302 of 302 from Escherichia coli K-12 : B1245; oligopeptide transport permease 1298782..1299690 Shigella flexneri 2a str. 2457T 1080986 NP_836938.1 CDS oppD NC_004741.1 1299702 1300715 D residues 1 to 337 of 337 are 99.10 pct identical to residues 1 to 337 of 337 from Escherichia coli K-12 : B1246; oligopeptide transporter ATP-binding component 1299702..1300715 Shigella flexneri 2a str. 2457T 1077707 NP_836939.1 CDS oppF NC_004741.1 1300712 1301716 D residues 1 to 334 of 334 are 97.90 pct identical to residues 1 to 334 of 334 from Escherichia coli K-12 : B1247; ATP-binding protein of oligopeptide ABC transport system 1300712..1301716 Shigella flexneri 2a str. 2457T 1077697 NP_836940.2 CDS S1335 NC_004741.1 1301769 1302098 R highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein complement(1301769..1302098) Shigella flexneri 2a str. 2457T 1077710 NP_836941.1 CDS cls NC_004741.1 1302133 1303593 R catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase complement(1302133..1303593) Shigella flexneri 2a str. 2457T 1077634 NP_836942.1 CDS kch NC_004741.1 1303964 1305217 R residues 1 to 417 of 417 are 95.44 pct identical to residues 1 to 417 of 417 from Escherichia coli K-12 : B1250; voltage-gated potassium channel complement(1303964..1305217) Shigella flexneri 2a str. 2457T 1077711 NP_836943.1 CDS S1338 NC_004741.1 1305580 1305882 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 1305580..1305882 Shigella flexneri 2a str. 2457T 1077712 NP_836944.1 CDS S1339 NC_004741.1 1306023 1306709 D residues 1 to 228 of 228 are 86.49 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 1306023..1306709 Shigella flexneri 2a str. 2457T 1077700 NP_836945.2 CDS yciI NC_004741.1 1306757 1307053 R unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein complement(1306757..1307053) Shigella flexneri 2a str. 2457T 1077720 NP_836946.1 CDS tonB NC_004741.1 1307268 1307996 D membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transporter 1307268..1307996 Shigella flexneri 2a str. 2457T 1077715 NP_836947.1 CDS yciA NC_004741.1 1308036 1308434 R YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase complement(1308036..1308434) Shigella flexneri 2a str. 2457T 1080851 NP_836948.1 CDS yciB NC_004741.1 1308539 1309078 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(1308539..1309078) Shigella flexneri 2a str. 2457T 1077719 NP_836949.1 CDS yciC NC_004741.1 1309108 1309851 R residues 1 to 247 of 247 are 80.97 pct identical to residues 1 to 247 of 247 from Escherichia coli K-12 : B1255; hypothetical protein complement(1309108..1309851) Shigella flexneri 2a str. 2457T 1077713 NP_836950.1 CDS yciD NC_004741.1 1310208 1310846 D receptor for colicin S4; outer membrane protein W 1310208..1310846 Shigella flexneri 2a str. 2457T 1077721 NP_836951.1 CDS yciE NC_004741.1 1310906 1311412 R residues 1 to 168 of 168 are 97.02 pct identical to residues 1 to 168 of 168 from Escherichia coli K-12 : B1257; hypothetical protein complement(1310906..1311412) Shigella flexneri 2a str. 2457T 1077722 NP_836952.1 CDS yciF NC_004741.1 1311458 1311958 R residues 1 to 166 of 166 are 81.92 pct identical to residues 1 to 166 of 166 from Escherichia coli K-12 : B1258; structural protein complement(1311458..1311958) Shigella flexneri 2a str. 2457T 1077652 NP_836953.1 CDS yciG NC_004741.1 1312044 1312280 R residues 1 to 62 of 78 are 98.38 pct identical to residues 1 to 62 of 78 from Escherichia coli K-12 : B1259; hypothetical protein complement(1312044..1312280) Shigella flexneri 2a str. 2457T 1077723 NP_836954.1 CDS trpA NC_004741.1 1312603 1313409 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1312603..1313409) Shigella flexneri 2a str. 2457T 1080872 NP_836955.1 CDS trpB NC_004741.1 1313409 1314602 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1313409..1314602) Shigella flexneri 2a str. 2457T 1077725 NP_836956.1 CDS trpC NC_004741.1 1314614 1315975 R monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase complement(1314614..1315975) Shigella flexneri 2a str. 2457T 1077749 NP_836957.1 CDS trpD NC_004741.1 1315976 1317571 R bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase complement(1315976..1317571) Shigella flexneri 2a str. 2457T 1077728 NP_836958.1 CDS trpE NC_004741.1 1317571 1319133 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1317571..1319133) Shigella flexneri 2a str. 2457T 1077739 NP_836960.1 CDS yciV NC_004741.1 1319407 1320288 D residues 1 to 293 of 293 are 94.53 pct identical to residues 1 to 293 of 293 from Escherichia coli K-12 : B1266; enzyme 1319407..1320288 Shigella flexneri 2a str. 2457T 1077732 NP_836961.1 CDS yciO NC_004741.1 1320249 1320905 D residues 1 to 218 of 218 are 100.00 pct identical to residues 1 to 218 of 218 from Escherichia coli K-12 : B1267; hypothetical protein 1320249..1320905 Shigella flexneri 2a str. 2457T 1077734 NP_836962.1 CDS yciL NC_004741.1 1321006 1321878 D catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1321006..1321878 Shigella flexneri 2a str. 2457T 1077733 NP_836963.1 CDS btuR NC_004741.1 1321918 1322508 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(1321918..1322508) Shigella flexneri 2a str. 2457T 1077716 NP_836964.1 CDS yciK NC_004741.1 1322505 1323263 R residues 1 to 252 of 252 are 99.20 pct identical to residues 1 to 252 of 252 from Escherichia coli K-12 : B1271; short chain dehydrogenase complement(1322505..1323263) Shigella flexneri 2a str. 2457T 1077737 NP_836965.1 CDS sohB NC_004741.1 1323483 1324532 D SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1323483..1324532 Shigella flexneri 2a str. 2457T 1077726 NP_836966.1 CDS yciN NC_004741.1 1324568 1324819 R residues 1 to 83 of 83 are 100.00 pct identical to residues 1 to 83 of 83 from Escherichia coli K-12 : B1273; hypothetical protein complement(1324568..1324819) Shigella flexneri 2a str. 2457T 1077740 NP_836967.1 CDS topA NC_004741.1 1325199 1327796 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1325199..1327796 Shigella flexneri 2a str. 2457T 1077741 NP_836968.1 CDS cysB NC_004741.1 1328006 1328980 D LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1328006..1328980 Shigella flexneri 2a str. 2457T 1077747 NP_836969.1 CDS acnA NC_004741.1 1329982 1332657 D Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1329982..1332657 Shigella flexneri 2a str. 2457T 1077742 NP_836970.1 CDS ribA NC_004741.1 1332721 1333311 R catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II complement(1332721..1333311) Shigella flexneri 2a str. 2457T 1077746 NP_836971.1 CDS pgpB NC_004741.1 1333481 1334245 D residues 1 to 254 of 254 are 94.09 pct identical to residues 1 to 254 of 254 from Escherichia coli K-12 : B1278; membrane bound; phosphatidylglycerophosphatase B 1333481..1334245 Shigella flexneri 2a str. 2457T 1077744 NP_836972.1 CDS yciS NC_004741.1 1334394 1334702 D residues 1 to 102 of 102 are 87.25 pct identical to residues 1 to 102 of 102 from Escherichia coli K-12 : B1279; hypothetical protein 1334394..1334702 Shigella flexneri 2a str. 2457T 1077717 NP_836973.1 CDS yciM NC_004741.1 1334709 1335878 D residues 10 to 389 of 389 are 99.73 pct identical to residues 10 to 389 of 389 from Escherichia coli K-12 : B1280; tetratricopeptide repeat protein 1334709..1335878 Shigella flexneri 2a str. 2457T 1077745 NP_836974.1 CDS pyrF NC_004741.1 1336071 1336808 D OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1336071..1336808 Shigella flexneri 2a str. 2457T 1079523 NP_836975.1 CDS yciH NC_004741.1 1336805 1337134 D involved in start site selection during the initiation of translation; translation initiation factor Sui1 1336805..1337134 Shigella flexneri 2a str. 2457T 1077748 NP_836976.1 CDS osmB NC_004741.1 1337260 1337478 R residues 1 to 72 of 72 are 54.16 pct identical to residues 1 to 72 of 72 from Escherichia coli K-12 : B1283; lipoprotein complement(1337260..1337478) Shigella flexneri 2a str. 2457T 1077727 NP_836977.1 CDS S1371 NC_004741.1 1337747 1338496 R residues 1 to 249 of 249 are 99.59 pct identical to residues 1 to 249 of 249 from Escherichia coli K-12 : B1284; DEOR-type transcriptional regulator complement(1337747..1338496) Shigella flexneri 2a str. 2457T 1077751 NP_836978.1 CDS rnb NC_004741.1 1341116 1343050 R Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II complement(1341116..1343050) Shigella flexneri 2a str. 2457T 1077752 NP_836979.1 CDS yciW NC_004741.1 1343118 1344245 R residues 1 to 375 of 375 are 93.06 pct identical to residues 27 to 401 of 401 from Escherichia coli K-12 : B1287; oxidoreductase complement(1343118..1344245) Shigella flexneri 2a str. 2457T 1077731 NP_836980.1 CDS fabI NC_004741.1 1344389 1345177 R Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase complement(1344389..1345177) Shigella flexneri 2a str. 2457T 1077753 NP_836981.1 CDS ycjD NC_004741.1 1345545 1345898 R residues 1 to 117 of 117 are 95.72 pct identical to residues 1 to 117 of 117 from Escherichia coli K-12 : B1289; hypothetical protein complement(1345545..1345898) Shigella flexneri 2a str. 2457T 1077895 NP_836982.1 CDS sapF NC_004741.1 1345966 1346772 R residues 1 to 268 of 268 are 100.00 pct identical to residues 1 to 268 of 268 from Escherichia coli K-12 : B1290; ATP-binding protein of peptide transport system complement(1345966..1346772) Shigella flexneri 2a str. 2457T 1077755 NP_836983.1 CDS sapD NC_004741.1 1346774 1347766 R residues 1 to 330 of 330 are 100.00 pct identical to residues 1 to 330 of 330 from Escherichia coli K-12 : B1291; ATP-binding protein of peptide transport system complement(1346774..1347766) Shigella flexneri 2a str. 2457T 1077757 NP_836984.1 CDS sapC NC_004741.1 1347766 1348656 R residues 1 to 296 of 296 are 94.59 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 : B1292; peptide transport permease complement(1347766..1348656) Shigella flexneri 2a str. 2457T 1077743 NP_836985.1 CDS sapB NC_004741.1 1348643 1349608 R residues 23 to 321 of 321 are 93.31 pct identical to residues 23 to 321 of 321 from Escherichia coli K-12 : B1293; peptide transport permease complement(1348643..1349608) Shigella flexneri 2a str. 2457T 1080636 NP_836986.1 CDS sapA NC_004741.1 1349605 1351248 R residues 1 to 547 of 547 are 95.24 pct identical to residues 1 to 547 of 547 from Escherichia coli K-12 : B1294; peptide transport periplasmic protein complement(1349605..1351248) Shigella flexneri 2a str. 2457T 1077759 NP_836987.1 CDS ycjJ NC_004741.1 1351939 1353324 R residues 1 to 461 of 461 are 99.78 pct identical to residues 19 to 479 of 479 from Escherichia coli K-12 : B1296; amino acid/amine transport protein complement(1351939..1353324) Shigella flexneri 2a str. 2457T 1077762 NP_836988.1 CDS S1384 NC_004741.1 1353627 1355045 R residues 1 to 472 of 472 are 99.36 pct identical to residues 27 to 498 of 498 from Escherichia coli K-12 : B1297; glutamine synthetase complement(1353627..1355045) Shigella flexneri 2a str. 2457T 1077761 NP_836989.1 CDS puuD NC_004741.1 1355245 1356021 D catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1355245..1356021 Shigella flexneri 2a str. 2457T 1077782 NP_836990.1 CDS ycjC NC_004741.1 1356048 1356605 D regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1356048..1356605 Shigella flexneri 2a str. 2457T 1077763 NP_836991.1 CDS aldH NC_004741.1 1356755 1358242 D catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1356755..1358242 Shigella flexneri 2a str. 2457T 1077750 NP_836992.1 CDS ordL NC_004741.1 1358244 1359524 D residues 1 to 426 of 426 are 96.00 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 : B1301; oxidoreductase 1358244..1359524 Shigella flexneri 2a str. 2457T 1077764 NP_836993.1 CDS goaG NC_004741.1 1359562 1360827 D putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate transaminase 1359562..1360827 Shigella flexneri 2a str. 2457T 1079511 NP_836994.2 CDS pspF NC_004741.1 1360947 1361924 R transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator complement(1360947..1361924) Shigella flexneri 2a str. 2457T 1077765 NP_836995.1 CDS pspA NC_004741.1 1362091 1362759 D involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1362091..1362759 Shigella flexneri 2a str. 2457T 1080731 NP_836996.1 CDS pspB NC_004741.1 1362813 1363037 D acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1362813..1363037 Shigella flexneri 2a str. 2457T 1077768 NP_836997.1 CDS pspC NC_004741.1 1363037 1363396 D with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1363037..1363396 Shigella flexneri 2a str. 2457T 1077771 NP_836998.1 CDS pspD NC_004741.1 1363405 1363626 D residues 1 to 73 of 73 are 98.63 pct identical to residues 1 to 73 of 73 from Escherichia coli K-12 : B1307; peripheral inner membrane phage-shock protein 1363405..1363626 Shigella flexneri 2a str. 2457T 1077770 NP_836999.1 CDS pspE NC_004741.1 1363669 1364016 D rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1363669..1364016 Shigella flexneri 2a str. 2457T 1078545 NP_837000.1 CDS S1397 NC_004741.1 1365387 1365662 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1365387..1365662 Shigella flexneri 2a str. 2457T 1077775 NP_837001.1 CDS S1398 NC_004741.1 1365581 1366084 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1365581..1366084 Shigella flexneri 2a str. 2457T 1078548 NP_837002.1 CDS ycjO NC_004741.1 1368001 1368882 D residues 1 to 293 of 293 are 88.73 pct identical to residues 1 to 293 of 293 from Escherichia coli K-12 : B1311; binding-protein dependent transport protein 1368001..1368882 Shigella flexneri 2a str. 2457T 1077779 NP_837003.1 CDS ycjP NC_004741.1 1368869 1369711 D residues 1 to 280 of 280 are 94.64 pct identical to residues 1 to 280 of 280 from Escherichia coli K-12 : B1312; transport system permease 1368869..1369711 Shigella flexneri 2a str. 2457T 1077780 NP_837004.1 CDS ycjQ NC_004741.1 1369742 1370794 D residues 1 to 350 of 350 are 96.28 pct identical to residues 1 to 350 of 350 from Escherichia coli K-12 : B1313; oxidoreductase 1369742..1370794 Shigella flexneri 2a str. 2457T 1077776 NP_837005.1 CDS ycjS NC_004741.1 1371597 1372652 D residues 1 to 351 of 351 are 95.15 pct identical to residues 1 to 351 of 351 from Escherichia coli K-12 : B1315; dehydrogenase 1371597..1372652 Shigella flexneri 2a str. 2457T 1077082 NP_837006.1 CDS ycjT NC_004741.1 1372649 1374916 D residues 1 to 755 of 755 are 96.55 pct identical to residues 1 to 755 of 755 from Escherichia coli K-12 : B1316; hypothetical protein 1372649..1374916 Shigella flexneri 2a str. 2457T 1077785 NP_837007.1 CDS ycjU NC_004741.1 1374913 1375572 D residues 1 to 219 of 219 are 97.26 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B1317; beta-phosphoglucomutase 1374913..1375572 Shigella flexneri 2a str. 2457T 1078550 NP_837008.1 CDS ycjV NC_004741.1 1375586 1376554 D residues 1 to 322 of 322 are 95.34 pct identical to residues 1 to 322 of 322 from Escherichia coli K-12 : B1318; ATP-binding component of a transport system 1375586..1376554 Shigella flexneri 2a str. 2457T 1077786 NP_837009.1 CDS ycjW NC_004741.1 1377723 1378721 R residues 1 to 332 of 332 are 95.48 pct identical to residues 1 to 332 of 332 from Escherichia coli K-12 : B1320; LACI-type transcriptional regulator complement(1377723..1378721) Shigella flexneri 2a str. 2457T 1080748 NP_837010.1 CDS ycjX NC_004741.1 1378877 1380274 D residues 1 to 465 of 465 are 98.06 pct identical to residues 1 to 465 of 465 from Escherichia coli K-12 : B1321; enzyme 1378877..1380274 Shigella flexneri 2a str. 2457T 1077788 NP_837011.1 CDS ycjF NC_004741.1 1380271 1381332 D residues 1 to 353 of 353 are 90.65 pct identical to residues 1 to 353 of 353 from Escherichia coli K-12 : B1322; hypothetical protein 1380271..1381332 Shigella flexneri 2a str. 2457T 1078749 NP_837012.1 CDS tyrR NC_004741.1 1381480 1383021 D regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1381480..1383021 Shigella flexneri 2a str. 2457T 1077789 NP_837013.1 CDS tpx NC_004741.1 1383065 1383571 R antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase complement(1383065..1383571) Shigella flexneri 2a str. 2457T 1077790 NP_837014.1 CDS ycjG NC_004741.1 1383690 1384655 D residues 1 to 321 of 321 are 92.21 pct identical to residues 15 to 335 of 335 from Escherichia coli K-12 : B1325; muconate cycloisomerase I 1383690..1384655 Shigella flexneri 2a str. 2457T 1077791 NP_837015.1 CDS ycjI NC_004741.1 1384630 1385358 R residues 1 to 242 of 242 are 98.76 pct identical to residues 21 to 262 of 262 from Escherichia coli K-12 : B1326; murein peptide amidase A complement(1384630..1385358) Shigella flexneri 2a str. 2457T 1077792 NP_837016.1 CDS S1416 NC_004741.1 1385649 1386287 R residues 1 to 212 of 212 are 99.05 pct identical to residues 5 to 216 of 216 from GenPept : >gb|AAG56475.1|AE005373_9 (AE005373) Z2446 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein complement(1385649..1386287) Shigella flexneri 2a str. 2457T 1077793 NP_837017.1 CDS S1418 NC_004741.1 1387115 1388200 D residues 1 to 348 of 361 are 89.65 pct identical to residues 1 to 348 of 398 from GenPept : >gb|AAL72392.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl4 orf 1387115..1388200 Shigella flexneri 2a str. 2457T 1080439 NP_837018.1 CDS ycjZ NC_004741.1 1389744 1390226 D residues 1 to 145 of 160 are 85.51 pct identical to residues 1 to 145 of 299 from Escherichia coli K-12 : B1328; LYSR-type transcriptional regulator 1389744..1390226 Shigella flexneri 2a str. 2457T 1077795 NP_837019.1 CDS S1422 NC_004741.1 1390223 1390936 R residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB complement(1390223..1390936) Shigella flexneri 2a str. 2457T 1077796 NP_837020.1 CDS S1423 NC_004741.1 1391077 1391379 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA complement(1391077..1391379) Shigella flexneri 2a str. 2457T 1077798 NP_837021.1 CDS S1424 NC_004741.1 1392226 1393860 D residues 1 to 544 of 544 are 99.63 pct identical to residues 1 to 544 of 544 from Escherichia coli K-12 : B1329; transport periplasmic protein 1392226..1393860 Shigella flexneri 2a str. 2457T 1079542 NP_837022.1 CDS S1425 NC_004741.1 1393911 1394942 R residues 1 to 343 of 343 are 92.41 pct identical to residues 1 to 343 of 343 from Escherichia coli K-12 : B1330; hypothetical protein complement(1393911..1394942) Shigella flexneri 2a str. 2457T 1077799 NP_837023.1 CDS S1426 NC_004741.1 1395070 1395372 D residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 1395070..1395372 Shigella flexneri 2a str. 2457T 1077800 NP_837024.1 CDS S1427 NC_004741.1 1395618 1396190 R residues 1 to 183 of 190 are 99.45 pct identical to residues 206 to 388 of 406 from GenPept : >gb|AAK85176.1| (AF294823) transposase [Shigella sonnei]; IS91 orf complement(1395618..1396190) Shigella flexneri 2a str. 2457T 1080952 NP_837025.1 CDS S1428 NC_004741.1 1396190 1396804 R residues 1 to 199 of 204 are 98.49 pct identical to residues 1 to 199 of 426 from GenPept : >emb|CAA34970.1| (X17114) transposase IS91 [Escherichia coli]; IS91 orf complement(1396190..1396804) Shigella flexneri 2a str. 2457T 1077802 NP_837026.1 CDS S1429 NC_004741.1 1396804 1397169 R residues 1 to 121 of 121 are 90.08 pct identical to residues 1 to 121 of 121 from GenPept : >gb|AAK85177.1| (AF294823) InsA [Shigella sonnei]; IS91 orf complement(1396804..1397169) Shigella flexneri 2a str. 2457T 1077966 NP_837027.1 CDS S1431 NC_004741.1 1397440 1397841 D residues 1 to 124 of 133 are 100.00 pct identical to residues 72 to 195 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; IS911 orfB 1397440..1397841 Shigella flexneri 2a str. 2457T 1077803 NP_837028.1 CDS ydaA NC_004741.1 1398562 1399512 R with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE complement(1398562..1399512) Shigella flexneri 2a str. 2457T 1077805 NP_837029.1 CDS fnr NC_004741.1 1399664 1400416 R Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator complement(1399664..1400416) Shigella flexneri 2a str. 2457T 1077807 NP_837030.1 CDS ogt NC_004741.1 1400611 1401126 R residues 1 to 171 of 171 are 91.81 pct identical to residues 1 to 171 of 171 from Escherichia coli K-12 : B1335; O-6-alkylguanine-DNA:cysteine-protein methyltransferase complement(1400611..1401126) Shigella flexneri 2a str. 2457T 1076535 NP_837031.1 CDS S1430 NC_004741.1 1401670 1402056 R no significant similarities; hypothetical protein complement(1401670..1402056) Shigella flexneri 2a str. 2457T 1078064 NP_837032.1 CDS S1439 NC_004741.1 1402582 1403229 D residues 4 to 213 of 215 are 30.80 pct identical to residues 26 to 234 of 365 from GenPept : >emb|CAC49806.1| (AL603647) protein secretion protein, HlyD family, similar to E. coli EmrK [Sinorhizobium meliloti]; secretion protein 1402582..1403229 Shigella flexneri 2a str. 2457T 1077811 NP_837033.1 CDS S1440 NC_004741.1 1403393 1403659 R residues 1 to 88 of 88 are 100.00 pct identical to residues 1 to 88 of 88 from GenPept : >gb|AAL72506.1| (AF386526) transposase-like protein [Shigella flexneri 2a]; IS1294 transposase complement(1403393..1403659) Shigella flexneri 2a str. 2457T 1077813 NP_837034.1 CDS S1441 NC_004741.1 1403767 1404591 R residues 1 to 274 of 274 are 99.27 pct identical to residues 1 to 274 of 399 from GenPept : >gb|AAL72439.1| (AF386526) transposase [Shigella flexneri 2a]; IS1294 transposase complement(1403767..1404591) Shigella flexneri 2a str. 2457T 1077878 NP_837035.1 CDS S1443 NC_004741.1 1404902 1405297 D residues 2 to 129 of 131 are 56.25 pct identical to residues 236 to 363 of 367 from GenPept : >dbj|BAB49683.1| (AP003000) probable secretion protein [Mesorhizobium loti]; secretion protein 1404902..1405297 Shigella flexneri 2a str. 2457T 1077814 NP_837036.1 CDS zntB NC_004741.1 1409073 1410056 D residues 1 to 327 of 327 are 93.27 pct identical to residues 1 to 327 of 327 from Escherichia coli K-12 : B1342; zinc transporter 1409073..1410056 Shigella flexneri 2a str. 2457T 1077816 NP_837037.1 CDS dbpA NC_004741.1 1410534 1411901 D exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1410534..1411901 Shigella flexneri 2a str. 2457T 1077817 NP_837038.1 CDS ydaO NC_004741.1 1412030 1412965 R TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase complement(1412030..1412965) Shigella flexneri 2a str. 2457T 1077818 NP_837039.1 CDS ynaF NC_004741.1 1413141 1413647 R residues 1 to 168 of 168 are 99.40 pct identical to residues 1 to 168 of 168 from Escherichia coli K-12 : B1376; filament protein complement(1413141..1413647) Shigella flexneri 2a str. 2457T 1077819 NP_837040.1 CDS ydbK NC_004741.1 1415212 1418736 R residues 1 to 1174 of 1174 are 99.14 pct identical to residues 1 to 1174 of 1174 from Escherichia coli K-12 : B1378; oxidoreductase, Fe-S subunit complement(1415212..1418736) Shigella flexneri 2a str. 2457T 1077822 NP_837041.1 CDS S1453 NC_004741.1 1419409 1419912 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(1419409..1419912) Shigella flexneri 2a str. 2457T 1077824 NP_837042.1 CDS S1454 NC_004741.1 1419831 1420106 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1419831..1420106) Shigella flexneri 2a str. 2457T 1077826 NP_837043.1 CDS ydbL NC_004741.1 1420558 1420887 R residues 1 to 109 of 109 are 97.24 pct identical to residues 2 to 110 of 110 from Escherichia coli K-12 : B1383; hypothetical protein complement(1420558..1420887) Shigella flexneri 2a str. 2457T 1077827 NP_837044.1 CDS ynbE NC_004741.1 1420892 1421077 R residues 1 to 61 of 61 are 100.00 pct identical to residues 1 to 61 of 61 from Escherichia coli K-12 : B1382; hypothetical protein complement(1420892..1421077) Shigella flexneri 2a str. 2457T 1077828 NP_837045.1 CDS ydbH NC_004741.1 1421074 1423713 R residues 29 to 879 of 879 are 96.94 pct identical to residues 29 to 879 of 879 from Escherichia coli K-12 : B1381; hypothetical protein complement(1421074..1423713) Shigella flexneri 2a str. 2457T 1077831 NP_837046.1 CDS ldhA NC_004741.1 1423921 1424910 D Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthes; D-lactate dehydrogenase 1423921..1424910 Shigella flexneri 2a str. 2457T 1077832 NP_837047.1 CDS S1461 NC_004741.1 1425347 1425850 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(1425347..1425850) Shigella flexneri 2a str. 2457T 1077834 NP_837048.1 CDS S1462 NC_004741.1 1425769 1426044 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1425769..1426044) Shigella flexneri 2a str. 2457T 1077835 NP_837049.1 CDS ydbD NC_004741.1 1426639 1428273 D residues 1 to 544 of 544 are 98.16 pct identical to residues 227 to 770 of 770 from Escherichia coli K-12 : B1407; hypothetical protein 1426639..1428273 Shigella flexneri 2a str. 2457T 1077836 NP_837050.1 CDS S1464 NC_004741.1 1428444 1429049 D residues 1 to 200 of 201 are 82.99 pct identical to residues 3 to 202 of 203 from Escherichia coli K-12 : B1408; hypothetical protein 1428444..1429049 Shigella flexneri 2a str. 2457T 1077837 NP_837051.1 CDS S1465 NC_004741.1 1429201 1429944 D residues 1 to 264 of 264 are 79.92 pct identical to residues 35 to 298 of 298 from Escherichia coli K-12 : B1409; phosphatidate cytidylyltransferase 1429201..1429944 Shigella flexneri 2a str. 2457T 1077838 NP_837052.1 CDS S1466 NC_004741.1 1429960 1431717 D residues 1 to 585 of 585 are 96.92 pct identical to residues 1 to 585 of 585 from Escherichia coli K-12 : B1410; hypothetical protein 1429960..1431717 Shigella flexneri 2a str. 2457T 1077839 NP_837053.1 CDS S1468 NC_004741.1 1432419 1433132 R residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAB86997.1| (U97492) hypothetical 31 KD protein [Shigella flexneri]; IS600 orfB complement(1432419..1433132) Shigella flexneri 2a str. 2457T 1077841 NP_837054.1 CDS S1469 NC_004741.1 1433273 1433575 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA complement(1433273..1433575) Shigella flexneri 2a str. 2457T 1077842 NP_837055.1 CDS acpD NC_004741.1 1434338 1434943 R FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase complement(1434338..1434943) Shigella flexneri 2a str. 2457T 1077844 NP_837056.1 CDS hrpA NC_004741.1 1435201 1439046 D involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1435201..1439046 Shigella flexneri 2a str. 2457T 1080893 NP_837057.1 CDS S1473 NC_004741.1 1439247 1439960 R residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB complement(1439247..1439960) Shigella flexneri 2a str. 2457T 1077845 NP_837058.1 CDS aldA NC_004741.1 1441195 1442634 D NAD-linked; aldehyde dehydrogenase A 1441195..1442634 Shigella flexneri 2a str. 2457T 1077848 NP_837059.2 CDS cybB NC_004741.1 1443865 1444395 D B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1443865..1444395 Shigella flexneri 2a str. 2457T 1077866 NP_837060.1 CDS ydcA NC_004741.1 1444640 1444813 D residues 1 to 57 of 57 are 100.00 pct identical to residues 1 to 57 of 57 from Escherichia coli K-12 : B1419; hypothetical protein 1444640..1444813 Shigella flexneri 2a str. 2457T 1077850 NP_837061.1 CDS S1482 NC_004741.1 1445135 1445986 R residues 1 to 283 of 283 are 98.93 pct identical to residues 1 to 283 of 283 from GenPept : >gb|AAC76582.1| (AE000433) IS150 transposase [Escherichia coli K12]; partial; IS103 orf complement(1445135..1445986) Shigella flexneri 2a str. 2457T 1077801 NP_837062.1 CDS S1483 NC_004741.1 1445983 1446504 R residues 1 to 173 of 173 are 100.00 pct identical to residues 1 to 173 of 173 from GenPept : >gb|AAB18534.1| (U00039) orfA in IS150 [Escherichia coli]; partial; IS103 orf complement(1445983..1446504) Shigella flexneri 2a str. 2457T 1077858 NP_837063.1 CDS trg NC_004741.1 1446880 1448520 D residues 1 to 546 of 546 are 87.72 pct identical to residues 1 to 546 of 546 from Escherichia coli K-12 : B1421; methyl-accepting chemotaxis protein III, ribose sensor receptor 1446880..1448520 Shigella flexneri 2a str. 2457T 1077859 NP_837064.1 CDS S1486 NC_004741.1 1448558 1449622 R residues 1 to 354 of 354 are 99.15 pct identical to residues 1 to 354 of 354 from Escherichia coli K-12 : B1422; LYSR-type transcriptional regulator complement(1448558..1449622) Shigella flexneri 2a str. 2457T 1077862 NP_837065.1 CDS S1487 NC_004741.1 1449698 1451041 D residues 1 to 447 of 447 are 96.86 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 : B1423; hypothetical protein 1449698..1451041 Shigella flexneri 2a str. 2457T 1077855 NP_837066.1 CDS mdoD NC_004741.1 1451266 1452921 D involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1451266..1452921 Shigella flexneri 2a str. 2457T 1077864 NP_837067.1 CDS S1489 NC_004741.1 1452842 1453045 R residues 1 to 67 of 67 are 98.50 pct identical to residues 1 to 67 of 67 from Escherichia coli K-12 : B1425; hypothetical protein complement(1452842..1453045) Shigella flexneri 2a str. 2457T 1077847 NP_837068.1 CDS ydcH NC_004741.1 1453118 1453285 D residues 1 to 55 of 55 are 100.00 pct identical to residues 1 to 55 of 55 from Escherichia coli K-12 : B1426; hypothetical protein 1453118..1453285 Shigella flexneri 2a str. 2457T 1077865 NP_837069.1 CDS rimL NC_004741.1 1453348 1453884 D residues 1 to 178 of 178 are 98.31 pct identical to residues 1 to 178 of 179 from Escherichia coli K-12 : B1427; involved in acetylation of N-terminal serine of 30S ribosomal subunit protein L7; ribosomal-protein-L7/L12-serine acetyltransferase 1453348..1453884 Shigella flexneri 2a str. 2457T 1077880 NP_837070.1 CDS S1492 NC_004741.1 1453879 1454859 R residues 1 to 326 of 326 are 98.46 pct identical to residues 1 to 326 of 326 from Escherichia coli K-12 : B1428; hypothetical protein complement(1453879..1454859) Shigella flexneri 2a str. 2457T 1077867 NP_837071.1 CDS tehA NC_004741.1 1454983 1455975 D residues 1 to 330 of 330 are 94.24 pct identical to residues 1 to 330 of 330 from Escherichia coli K-12 : B1429; potassium-tellurite ethidium and proflavin transporter 1454983..1455975 Shigella flexneri 2a str. 2457T 1077868 NP_837072.1 CDS tehB NC_004741.1 1455972 1456565 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 1455972..1456565 Shigella flexneri 2a str. 2457T 1077871 NP_837073.1 CDS S1495 NC_004741.1 1456868 1457524 D residues 1 to 218 of 218 are 91.44 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 : B1431; hypothetical protein 1456868..1457524 Shigella flexneri 2a str. 2457T 1077887 NP_837074.1 CDS S1497 NC_004741.1 1459137 1460324 R residues 1 to 388 of 395 are 97.93 pct identical to residues 1 to 388 of 426 from GenPept : >emb|CAA34970.1| (X17114) transposase IS91 [Escherichia coli]; partial; IS91 orf complement(1459137..1460324) Shigella flexneri 2a str. 2457T 1079918 NP_837075.1 CDS S1498 NC_004741.1 1460353 1460679 D residues 1 to 67 of 108 are 98.50 pct identical to residues 1 to 67 of 79 from GenPept : >gb|AAC70084.1| (AF074613) unknown [Escherichia coli O157:H7]; partial; IS91 orf 1460353..1460679 Shigella flexneri 2a str. 2457T 1077873 NP_837076.1 CDS S1499 NC_004741.1 1461247 1461522 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1461247..1461522 Shigella flexneri 2a str. 2457T 1077874 NP_837077.1 CDS S1500 NC_004741.1 1461441 1461944 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1461441..1461944 Shigella flexneri 2a str. 2457T 1076486 NP_837078.1 CDS S1502 NC_004741.1 1462735 1463037 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 1462735..1463037 Shigella flexneri 2a str. 2457T 1077921 NP_837079.1 CDS S1503 NC_004741.1 1463178 1463891 D residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 1463178..1463891 Shigella flexneri 2a str. 2457T 1077876 NP_837080.1 CDS S1504 NC_004741.1 1464148 1464423 R residues 1 to 91 of 91 are 96.70 pct identical to residues 1 to 91 of 91 from Escherichia coli K-12 : B1837; hypothetical protein complement(1464148..1464423) Shigella flexneri 2a str. 2457T 1077877 NP_837081.1 CDS S1505 NC_004741.1 1464444 1464680 R residues 1 to 78 of 78 are 100.00 pct identical to residues 6 to 83 of 83 from Escherichia coli K-12 : B1836; hypothetical protein complement(1464444..1464680) Shigella flexneri 2a str. 2457T 1079524 NP_837082.1 CDS S1508 NC_004741.1 1468906 1470189 R residues 1 to 427 of 427 are 95.55 pct identical to residues 1 to 427 of 427 from Escherichia coli K-12 : B1833; hypothetical protein complement(1468906..1470189) Shigella flexneri 2a str. 2457T 1077881 NP_837083.1 CDS S1509 NC_004741.1 1470319 1470816 D residues 1 to 165 of 165 are 98.18 pct identical to residues 19 to 183 of 183 from Escherichia coli K-12 : B1832; hypothetical protein 1470319..1470816 Shigella flexneri 2a str. 2457T 1080914 NP_837084.1 CDS yebJ NC_004741.1 1471492 1471611 D residues 1 to 39 of 39 are 100.00 pct identical to residues 1 to 39 of 39 from Escherichia coli K-12 : B1831; hypothetical protein 1471492..1471611 Shigella flexneri 2a str. 2457T 1077883 NP_837085.2 CDS prc NC_004741.1 1471631 1473679 D Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1471631..1473679 Shigella flexneri 2a str. 2457T 1077894 NP_837086.1 CDS htpX NC_004741.1 1473874 1474752 D metalloprotease; heat shock protein HtpX 1473874..1474752 Shigella flexneri 2a str. 2457T 1077884 NP_837087.1 CDS S1513 NC_004741.1 1474798 1476282 R residues 1 to 494 of 494 are 94.12 pct identical to residues 1 to 494 of 494 from Escherichia coli K-12 : B1828; transporter complement(1474798..1476282) Shigella flexneri 2a str. 2457T 1077885 NP_837088.1 CDS S1514 NC_004741.1 1476348 1477139 D residues 1 to 263 of 263 are 99.23 pct identical to residues 1 to 263 of 263 from Escherichia coli K-12 : B1827; regulator 1476348..1477139 Shigella flexneri 2a str. 2457T 1077870 NP_837089.1 CDS S1515 NC_004741.1 1477680 1477823 D residues 1 to 47 of 47 are 72.34 pct identical to residues 1 to 47 of 47 from Escherichia coli K-12 : B1826; hypothetical protein 1477680..1477823 Shigella flexneri 2a str. 2457T 1077886 NP_837090.1 CDS S1516 NC_004741.1 1477898 1478185 D residues 1 to 95 of 95 are 82.10 pct identical to residues 1 to 95 of 95 from Escherichia coli K-12 : B1825; hypothetical protein 1477898..1478185 Shigella flexneri 2a str. 2457T 1078656 NP_837091.1 CDS S1517 NC_004741.1 1478855 1478998 D residues 1 to 47 of 47 are 100.00 pct identical to residues 1 to 47 of 47 from Escherichia coli K-12 : B1824; hypothetical protein 1478855..1478998 Shigella flexneri 2a str. 2457T 1077890 NP_837092.1 CDS cspC NC_004741.1 1479011 1479220 D residues 1 to 69 of 69 are 100.00 pct identical to residues 1 to 69 of 69 from Escherichia coli K-12 : B1823; cold shock-like protein CspC 1479011..1479220 Shigella flexneri 2a str. 2457T 1077891 NP_837093.1 CDS rrmA NC_004741.1 1479386 1480195 D methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase A 1479386..1480195 Shigella flexneri 2a str. 2457T 1076871 NP_837094.1 CDS S1520 NC_004741.1 1480192 1480812 R membrane protein YebN; hypothetical protein complement(1480192..1480812) Shigella flexneri 2a str. 2457T 1077892 NP_837095.1 CDS S1521 NC_004741.1 1481221 1481724 R residues 1 to 167 of 167 are 89.22 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(1481221..1481724) Shigella flexneri 2a str. 2457T 1077893 NP_837096.1 CDS S1522 NC_004741.1 1481643 1481918 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1481643..1481918) Shigella flexneri 2a str. 2457T 1077889 NP_837097.1 CDS S1523 NC_004741.1 1481947 1482423 R residues 1 to 150 of 158 are 90.66 pct identical to residues 1 to 150 of 152 from Escherichia coli K-12 : B1820; hypothetical protein complement(1481947..1482423) Shigella flexneri 2a str. 2457T 1077896 NP_837098.1 CDS manZ NC_004741.1 1482478 1483338 R hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; mannose-specific PTS system protein IID complement(1482478..1483338) Shigella flexneri 2a str. 2457T 1077853 NP_837099.1 CDS manY NC_004741.1 1483342 1484142 R residues 1 to 266 of 266 are 94.36 pct identical to residues 1 to 266 of 266 from Escherichia coli K-12 : B1818; mannose-specific; PTS enzyme IIC complement(1483342..1484142) Shigella flexneri 2a str. 2457T 1077897 NP_837100.1 CDS manX NC_004741.1 1484205 1485176 R residues 1 to 323 of 323 are 91.02 pct identical to residues 1 to 323 of 323 from Escherichia coli K-12 : B1817; mannose-specific; PTS enzyme IIAB complement(1484205..1485176) Shigella flexneri 2a str. 2457T 1077900 NP_837101.1 CDS yoaE NC_004741.1 1485639 1487189 D residues 1 to 516 of 516 are 91.69 pct identical to residues 1 to 518 of 518 from Escherichia coli K-12 : B1816; transporter 1485639..1487189 Shigella flexneri 2a str. 2457T 1077901 NP_837102.1 CDS S1528 NC_004741.1 1487193 1488791 R residues 1 to 532 of 532 are 96.05 pct identical to residues 11 to 542 of 542 from Escherichia coli K-12 : B1815; hypothetical protein complement(1487193..1488791) Shigella flexneri 2a str. 2457T 1077925 NP_837103.1 CDS sdaA NC_004741.1 1488922 1490286 R residues 1 to 454 of 454 are 97.35 pct identical to residues 1 to 454 of 454 from Escherichia coli K-12 : B1814; L-serine deaminase complement(1488922..1490286) Shigella flexneri 2a str. 2457T 1077902 NP_837104.1 CDS yeaB NC_004741.1 1490470 1491048 R residues 1 to 192 of 192 are 92.18 pct identical to residues 1 to 192 of 192 from Escherichia coli K-12 : B1813; hypothetical protein complement(1490470..1491048) Shigella flexneri 2a str. 2457T 1077903 NP_837105.1 CDS pabB NC_004741.1 1491052 1492413 R catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; para-aminobenzoate synthase component I complement(1491052..1492413) Shigella flexneri 2a str. 2457T 1078761 NP_837106.1 CDS S1532 NC_004741.1 1492487 1492666 D residues 1 to 59 of 59 are 96.61 pct identical to residues 1 to 59 of 59 from Escherichia coli K-12 : B1811; hypothetical protein 1492487..1492666 Shigella flexneri 2a str. 2457T 1077907 NP_837107.1 CDS S1533 NC_004741.1 1492786 1493145 R residues 1 to 119 of 119 are 100.00 pct identical to residues 1 to 119 of 119 from Escherichia coli K-12 : B1810; hypothetical protein complement(1492786..1493145) Shigella flexneri 2a str. 2457T 1076957 NP_837108.1 CDS S1534 NC_004741.1 1493507 1493899 R residues 1 to 130 of 130 are 100.00 pct identical to residues 1 to 130 of 130 from Escherichia coli K-12 : B1809; hypothetical protein complement(1493507..1493899) Shigella flexneri 2a str. 2457T 1077908 NP_837109.1 CDS S1535 NC_004741.1 1493983 1495893 D residues 1 to 636 of 636 are 99.68 pct identical to residues 1 to 636 of 636 from Escherichia coli K-12 : B1808; enzyme 1493983..1495893 Shigella flexneri 2a str. 2457T 1077909 NP_837110.1 CDS yeaZ NC_004741.1 1495951 1496646 D residues 1 to 231 of 231 are 92.64 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 : B1807; hypothetical protein 1495951..1496646 Shigella flexneri 2a str. 2457T 1077979 NP_837111.1 CDS S1537 NC_004741.1 1496686 1497267 D residues 1 to 193 of 193 are 87.56 pct identical to residues 1 to 193 of 193 from Escherichia coli K-12 : B1806; outer membrane protein 1496686..1497267 Shigella flexneri 2a str. 2457T 1077910 NP_837112.1 CDS fadD NC_004741.1 1497407 1499158 D Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1497407..1499158 Shigella flexneri 2a str. 2457T 1077911 NP_837113.1 CDS rnd NC_004741.1 1499240 1500355 D residues 1 to 371 of 371 are 95.68 pct identical to residues 5 to 375 of 375 from Escherichia coli K-12 : B1804; processes tRNA precursor; ribonuclease D 1499240..1500355 Shigella flexneri 2a str. 2457T 1077692 NP_837114.1 CDS yeaX NC_004741.1 1500409 1501374 R residues 1 to 321 of 321 are 98.13 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B1803; diogenase beta subunit complement(1500409..1501374) Shigella flexneri 2a str. 2457T 1077913 NP_837115.1 CDS S1542 NC_004741.1 1502389 1502955 R residues 80 to 188 of 188 are 48.62 pct identical to residues 68 to 174 of 174 from GenPept : >gb|AAF01132.1|AF083977_53 (AF083977) c-repressor [Enterobacteria phage Mu]; repressor protein complement(1502389..1502955) Shigella flexneri 2a str. 2457T 1077934 NP_837116.1 CDS S1543 NC_004741.1 1503322 1503624 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 1503322..1503624 Shigella flexneri 2a str. 2457T 1077915 NP_837117.1 CDS S1544 NC_004741.1 1503765 1504478 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 1503765..1504478 Shigella flexneri 2a str. 2457T 1077905 NP_837118.1 CDS yeaP NC_004741.1 1505400 1506425 R residues 1 to 341 of 341 are 98.82 pct identical to residues 44 to 384 of 384 from Escherichia coli K-12 : B1794; hypothetical protein complement(1505400..1506425) Shigella flexneri 2a str. 2457T 1077918 NP_837119.1 CDS yoaF NC_004741.1 1506608 1506862 D residues 1 to 84 of 84 are 100.00 pct identical to residues 1 to 84 of 84 from Escherichia coli K-12 : B1793; hypothetical protein 1506608..1506862 Shigella flexneri 2a str. 2457T 1080908 NP_837120.1 CDS yeaO NC_004741.1 1506884 1507252 R residues 1 to 122 of 122 are 96.72 pct identical to residues 1 to 122 of 122 from Escherichia coli K-12 : B1792; hypothetical protein complement(1506884..1507252) Shigella flexneri 2a str. 2457T 1077919 NP_837121.1 CDS yeaN NC_004741.1 1507405 1508466 R residues 1 to 326 of 353 are 89.26 pct identical to residues 1 to 326 of 393 from Escherichia coli K-12 : B1791; amino acid/amine transport protein complement(1507405..1508466) Shigella flexneri 2a str. 2457T 1077854 NP_837122.1 CDS yeaL NC_004741.1 1509337 1509783 R residues 1 to 148 of 148 are 74.32 pct identical to residues 1 to 148 of 148 from Escherichia coli K-12 : B1789; hypothetical protein complement(1509337..1509783) Shigella flexneri 2a str. 2457T 1077857 NP_837123.1 CDS S1551 NC_004741.1 1509905 1510057 D residues 1 to 50 of 50 are 80.00 pct identical to residues 1 to 50 of 50 from Escherichia coli K-12 : B1788; hypothetical protein 1509905..1510057 Shigella flexneri 2a str. 2457T 1077923 NP_837124.1 CDS yeaK NC_004741.1 1510058 1510561 R residues 1 to 167 of 167 are 88.62 pct identical to residues 1 to 167 of 167 from Escherichia coli K-12 : B1787; hypothetical protein complement(1510058..1510561) Shigella flexneri 2a str. 2457T 1080727 NP_837125.1 CDS S1554 NC_004741.1 1512189 1512902 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 1512189..1512902 Shigella flexneri 2a str. 2457T 1077825 NP_837126.1 CDS yeaG NC_004741.1 1512927 1514306 R residues 1 to 455 of 459 are 99.56 pct identical to residues 1 to 455 of 644 from Escherichia coli K-12 : B1783; hypothetical protein complement(1512927..1514306) Shigella flexneri 2a str. 2457T 1077924 NP_837127.1 CDS yeaF NC_004741.1 1514742 1515488 D residues 1 to 248 of 248 are 100.00 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 : B1782; hypothetical protein 1514742..1515488 Shigella flexneri 2a str. 2457T 1080449 NP_837128.1 CDS S1557 NC_004741.1 1515578 1516339 D residues 1 to 253 of 253 are 83.09 pct identical to residues 1 to 284 of 284 from Escherichia coli K-12 : B1781; aldehyde reductase 1515578..1516339 Shigella flexneri 2a str. 2457T 1077926 NP_837129.1 CDS yeaD NC_004741.1 1516390 1517274 R residues 1 to 294 of 294 are 99.31 pct identical to residues 8 to 301 of 301 from Escherichia coli K-12 : B1780; hypothetical protein complement(1516390..1517274) Shigella flexneri 2a str. 2457T 1077927 NP_837130.1 CDS gapA NC_004741.1 1517358 1518353 R catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase complement(1517358..1518353) Shigella flexneri 2a str. 2457T 1077928 NP_837131.1 CDS yeaA NC_004741.1 1518695 1519108 D this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1518695..1519108 Shigella flexneri 2a str. 2457T 1080943 NP_837132.1 CDS S1561 NC_004741.1 1519150 1519422 D residues 1 to 90 of 90 are 97.77 pct identical to residues 16 to 105 of 105 from Escherichia coli K-12 : B1777; hypothetical protein 1519150..1519422 Shigella flexneri 2a str. 2457T 1077930 NP_837133.1 CDS S1562 NC_004741.1 1519792 1520868 D residues 1 to 358 of 358 are 99.16 pct identical to residues 1 to 358 of 358 from Escherichia coli K-12 : B1776; oxidoreductase 1519792..1520868 Shigella flexneri 2a str. 2457T 1077952 NP_837134.1 CDS S1563 NC_004741.1 1520895 1522274 D residues 1 to 459 of 459 are 90.63 pct identical to residues 1 to 459 of 459 from Escherichia coli K-12 : B1775; transporter 1520895..1522274 Shigella flexneri 2a str. 2457T 1077933 NP_837135.1 CDS S1565 NC_004741.1 1523357 1524193 D residues 1 to 278 of 278 are 98.20 pct identical to residues 1 to 278 of 278 from Escherichia coli K-12 : B1773; aldolase 1523357..1524193 Shigella flexneri 2a str. 2457T 1077935 NP_837136.1 CDS S1566 NC_004741.1 1524198 1525145 D residues 1 to 315 of 315 are 98.73 pct identical to residues 8 to 322 of 322 from Escherichia coli K-12 : B1772; kinase 1524198..1525145 Shigella flexneri 2a str. 2457T 1077943 NP_837137.1 CDS S1567 NC_004741.1 1525200 1526135 D residues 1 to 311 of 311 are 99.03 pct identical to residues 16 to 326 of 326 from Escherichia coli K-12 : B1771; hypothetical protein 1525200..1526135 Shigella flexneri 2a str. 2457T 1077936 NP_837138.1 CDS S1568 NC_004741.1 1526272 1527030 D residues 1 to 252 of 252 are 98.41 pct identical to residues 1 to 252 of 252 from Escherichia coli K-12 : B1770; DEOR-type transcriptional regulator 1526272..1527030 Shigella flexneri 2a str. 2457T 1077937 NP_837139.1 CDS ydjE NC_004741.1 1527148 1528506 D residues 1 to 452 of 452 are 95.79 pct identical to residues 1 to 452 of 452 from Escherichia coli K-12 : B1769; transporter 1527148..1528506 Shigella flexneri 2a str. 2457T 1078013 NP_837140.2 CDS ydjB NC_004741.1 1528599 1529240 R catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase complement(1528599..1529240) Shigella flexneri 2a str. 2457T 1077939 NP_837141.1 CDS ansA NC_004741.1 1529251 1530267 R converts asparagine to aspartate and ammonia; asparaginase complement(1529251..1530267) Shigella flexneri 2a str. 2457T 1077946 NP_837142.1 CDS sppA NC_004741.1 1530434 1532290 R SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 complement(1530434..1532290) Shigella flexneri 2a str. 2457T 1078030 NP_837143.1 CDS ydjA NC_004741.1 1532451 1533002 D residues 1 to 183 of 183 are 92.34 pct identical to residues 1 to 183 of 183 from Escherichia coli K-12 : B1765; hypothetical protein 1532451..1533002 Shigella flexneri 2a str. 2457T 1077947 NP_837144.1 CDS selD NC_004741.1 1533119 1534162 D catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1533119..1534162 Shigella flexneri 2a str. 2457T 1080913 NP_837145.1 CDS topB NC_004741.1 1534167 1536128 D decatenates replicating daughter chromosomes; DNA topoisomerase III 1534167..1536128 Shigella flexneri 2a str. 2457T 1077948 NP_837146.2 CDS S1578 NC_004741.1 1538704 1539069 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1538704..1539069 Shigella flexneri 2a str. 2457T 1077950 NP_837147.2 CDS S1579 NC_004741.1 1539027 1539932 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1539027..1539932 Shigella flexneri 2a str. 2457T 1077951 NP_837148.1 CDS S1580 NC_004741.1 1540327 1540599 D residues 1 to 90 of 90 are 98.88 pct identical to residues 1 to 90 of 90 from Escherichia coli K-12 : B1760; hypothetical protein 1540327..1540599 Shigella flexneri 2a str. 2457T 1078021 NP_837149.1 CDS S1581 NC_004741.1 1540565 1540972 R residues 1 to 120 of 135 are 96.66 pct identical to residues 1 to 120 of 135 from Escherichia coli K-12 : B1759; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase complement(1540565..1540972) Shigella flexneri 2a str. 2457T 1077954 NP_837150.1 CDS S1582 NC_004741.1 1541059 1541679 D residues 1 to 206 of 206 are 88.83 pct identical to residues 3 to 208 of 208 from Escherichia coli K-12 : B1758; cytochrome oxidase 1541059..1541679 Shigella flexneri 2a str. 2457T 1077843 NP_837151.1 CDS S1584 NC_004741.1 1543062 1543715 R residues 1 to 217 of 217 are 93.08 pct identical to residues 1 to 217 of 217 from Escherichia coli K-12 : B1756; ATP-binding component of a transport system complement(1543062..1543715) Shigella flexneri 2a str. 2457T 1080918 NP_837152.1 CDS S1588 NC_004741.1 1546096 1547424 D residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 1546096..1547424 Shigella flexneri 2a str. 2457T 1077960 NP_837153.1 CDS ynjA NC_004741.1 1547774 1548322 R residues 1 to 182 of 182 are 92.30 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 : B1753; hypothetical protein complement(1547774..1548322) Shigella flexneri 2a str. 2457T 1077992 NP_837154.1 CDS ydjZ NC_004741.1 1548322 1549026 R residues 1 to 233 of 234 are 91.41 pct identical to residues 2 to 234 of 235 from Escherichia coli K-12 : B1752; hypothetical protein complement(1548322..1549026) Shigella flexneri 2a str. 2457T 1077961 NP_837155.1 CDS ydjY NC_004741.1 1549044 1549883 R residues 1 to 279 of 279 are 92.47 pct identical to residues 1 to 279 of 279 from Escherichia coli K-12 : B1751; hypothetical protein complement(1549044..1549883) Shigella flexneri 2a str. 2457T 1077984 NP_837156.1 CDS ydjX NC_004741.1 1549726 1550436 R residues 1 to 236 of 236 are 91.10 pct identical to residues 17 to 252 of 252 from Escherichia coli K-12 : B1750; hypothetical protein complement(1549726..1550436) Shigella flexneri 2a str. 2457T 1077962 NP_837157.1 CDS xthA NC_004741.1 1550603 1551409 R removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III complement(1550603..1551409) Shigella flexneri 2a str. 2457T 1077965 NP_837158.1 CDS S1596 NC_004741.1 1553075 1554106 D residues 1 to 343 of 343 are 99.70 pct identical to residues 2 to 344 of 344 from Escherichia coli K-12 : B1747; arginine succinyltransferase 1553075..1554106 Shigella flexneri 2a str. 2457T 1077968 NP_837159.1 CDS astD NC_004741.1 1554103 1555581 D a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 1554103..1555581 Shigella flexneri 2a str. 2457T 1077920 NP_837160.1 CDS ydjS NC_004741.1 1556904 1557872 D catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1556904..1557872 Shigella flexneri 2a str. 2457T 1077994 NP_837161.1 CDS spy NC_004741.1 1558202 1558687 D periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein 1558202..1558687 Shigella flexneri 2a str. 2457T 1077971 NP_837162.1 CDS S1601 NC_004741.1 1558890 1559465 D residues 1 to 191 of 191 are 98.42 pct identical to residues 22 to 212 of 212 from Escherichia coli K-12 : B1742; hypothetical protein 1558890..1559465 Shigella flexneri 2a str. 2457T 1077972 NP_837163.1 CDS S1602 NC_004741.1 1559425 1560312 R 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease complement(1559425..1560312) Shigella flexneri 2a str. 2457T 1077970 NP_837164.1 CDS nadE NC_004741.1 1560542 1561369 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1560542..1561369) Shigella flexneri 2a str. 2457T 1077973 NP_837165.1 CDS osmE NC_004741.1 1561571 1561909 D osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1561571..1561909 Shigella flexneri 2a str. 2457T 1079640 NP_837166.1 CDS celA NC_004741.1 1562208 1562528 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; N,N'-diacetylchitobiose-specific PTS system transporter subunit IIB 1562208..1562528 Shigella flexneri 2a str. 2457T 1077975 NP_837167.1 CDS celC NC_004741.1 1564020 1564370 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; N,N'-diacetylchitobiose-specific PTS system transporter subunit IIA 1564020..1564370 Shigella flexneri 2a str. 2457T 1077978 NP_837168.1 CDS S1609 NC_004741.1 1565070 1565573 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(1565070..1565573) Shigella flexneri 2a str. 2457T 1077941 NP_837169.1 CDS S1610 NC_004741.1 1565492 1565767 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1565492..1565767) Shigella flexneri 2a str. 2457T 1077980 NP_837170.1 CDS celF NC_004741.1 1566102 1567454 D residues 1 to 450 of 450 are 98.44 pct identical to residues 1 to 450 of 450 from Escherichia coli K-12 : B1734; cryptic phospho-beta-glucosidase; cryptic 1566102..1567454 Shigella flexneri 2a str. 2457T 1079635 NP_837171.1 CDS ydjC NC_004741.1 1567467 1568225 D residues 1 to 252 of 252 are 92.85 pct identical to residues 1 to 249 of 249 from Escherichia coli K-12 : B1733; hypothetical protein 1567467..1568225 Shigella flexneri 2a str. 2457T 1077981 NP_837172.1 CDS katE NC_004741.1 1568272 1570533 R Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II complement(1568272..1570533) Shigella flexneri 2a str. 2457T 1077829 NP_837173.1 CDS S1614 NC_004741.1 1570716 1570979 D residues 1 to 87 of 87 are 100.00 pct identical to residues 1 to 87 of 87 from Escherichia coli K-12 : B1731; cell division modulator 1570716..1570979 Shigella flexneri 2a str. 2457T 1077982 NP_837174.1 CDS S1616 NC_004741.1 1572008 1572511 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(1572008..1572511) Shigella flexneri 2a str. 2457T 1078001 NP_837175.1 CDS S1617 NC_004741.1 1572430 1572705 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1572430..1572705) Shigella flexneri 2a str. 2457T 1077983 NP_837176.1 CDS S1619 NC_004741.1 1574375 1574965 R residues 1 to 196 of 196 are 100.00 pct identical to residues 5 to 200 of 200 from Escherichia coli K-12 : B1728; hypothetical protein complement(1574375..1574965) Shigella flexneri 2a str. 2457T 1077985 NP_837177.1 CDS yniC NC_004741.1 1575128 1575796 R YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase complement(1575128..1575796) Shigella flexneri 2a str. 2457T 1077421 NP_837178.1 CDS S1621 NC_004741.1 1575943 1576479 D residues 1 to 178 of 178 are 98.87 pct identical to residues 1 to 178 of 178 from Escherichia coli K-12 : B1726; hypothetical protein 1575943..1576479 Shigella flexneri 2a str. 2457T 1077986 NP_837179.1 CDS S1622 NC_004741.1 1576520 1577380 R residues 1 to 286 of 286 are 99.30 pct identical to residues 1 to 286 of 286 from Escherichia coli K-12 : B1725; hypothetical protein complement(1576520..1577380) Shigella flexneri 2a str. 2457T 1080917 NP_837180.1 CDS S1623 NC_004741.1 1577486 1577776 R residues 1 to 96 of 96 are 98.95 pct identical to residues 1 to 96 of 96 from Escherichia coli K-12 : B1724; hypothetical protein complement(1577486..1577776) Shigella flexneri 2a str. 2457T 1077987 NP_837181.1 CDS pfkB NC_004741.1 1577877 1578806 R residues 1 to 309 of 309 are 99.35 pct identical to residues 1 to 309 of 309 from Escherichia coli K-12 : B1723; suppressor of pfkA; 6-phosphofructokinase complement(1577877..1578806) Shigella flexneri 2a str. 2457T 1077958 NP_837182.1 CDS S1625 NC_004741.1 1579126 1579851 D residues 1 to 241 of 241 are 99.58 pct identical to residues 12 to 252 of 252 from Escherichia coli K-12 : B1722; hypothetical protein 1579126..1579851 Shigella flexneri 2a str. 2457T 1077989 NP_837183.1 CDS S1627 NC_004741.1 1581158 1581661 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(1581158..1581661) Shigella flexneri 2a str. 2457T 1080915 NP_837184.1 CDS S1628 NC_004741.1 1581580 1581855 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1581580..1581855) Shigella flexneri 2a str. 2457T 1077993 NP_837185.1 CDS thrS NC_004741.1 1582814 1584742 D catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1582814..1584742 Shigella flexneri 2a str. 2457T 1077996 NP_837186.1 CDS infC NC_004741.1 1584854 1585288 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1584854..1585288 Shigella flexneri 2a str. 2457T 1077906 NP_837187.1 CDS rpmI NC_004741.1 1585385 1585582 D residues 1 to 65 of 65 are 70.76 pct identical to residues 1 to 65 of 65 from Escherichia coli K-12 : B1717; 50S ribosomal protein L35 1585385..1585582 Shigella flexneri 2a str. 2457T 1077997 NP_837188.1 CDS rplT NC_004741.1 1585635 1585991 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1585635..1585991 Shigella flexneri 2a str. 2457T 1077945 NP_837190.1 CDS pheS NC_004741.1 1586441 1587424 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1586441..1587424 Shigella flexneri 2a str. 2457T 1077999 NP_837191.1 CDS pheT NC_004741.1 1587439 1589826 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1587439..1589826 Shigella flexneri 2a str. 2457T 1079642 NP_837192.1 CDS ihfA NC_004741.1 1589831 1590130 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1589831..1590130 Shigella flexneri 2a str. 2457T 1078000 NP_837193.1 CDS btuC NC_004741.1 1590231 1591211 D with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1590231..1591211 Shigella flexneri 2a str. 2457T 1077953 NP_837194.1 CDS btuE NC_004741.1 1591274 1591825 D similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase 1591274..1591825 Shigella flexneri 2a str. 2457T 1078002 NP_837195.1 CDS btuD NC_004741.1 1591825 1592574 D ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1591825..1592574 Shigella flexneri 2a str. 2457T 1078045 NP_837196.1 CDS nlpC NC_004741.1 1592652 1593116 D residues 1 to 154 of 154 are 98.70 pct identical to residues 1 to 154 of 154 from Escherichia coli K-12 : B1708; lipoprotein 1592652..1593116 Shigella flexneri 2a str. 2457T 1078003 NP_837197.1 CDS S1641 NC_004741.1 1593363 1594076 D residues 1 to 237 of 237 are 97.04 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B1707; hypothetical protein 1593363..1594076 Shigella flexneri 2a str. 2457T 1077944 NP_837198.1 CDS S1642 NC_004741.1 1594140 1595576 D residues 1 to 478 of 478 are 97.69 pct identical to residues 1 to 478 of 478 from Escherichia coli K-12 : B1706; hypothetical protein 1594140..1595576 Shigella flexneri 2a str. 2457T 1078004 NP_837199.1 CDS ydiE NC_004741.1 1595580 1595771 R residues 1 to 63 of 63 are 98.41 pct identical to residues 1 to 63 of 63 from Escherichia coli K-12 : B1705; hypothetical protein complement(1595580..1595771) Shigella flexneri 2a str. 2457T 1078047 NP_837200.1 CDS aroH NC_004741.1 1595903 1596949 R tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1595903..1596949) Shigella flexneri 2a str. 2457T 1079648 NP_837201.1 CDS ydiA NC_004741.1 1597106 1597939 R residues 1 to 277 of 277 are 95.66 pct identical to residues 1 to 277 of 277 from Escherichia coli K-12 : B1703; hypothetical protein complement(1597106..1597939) Shigella flexneri 2a str. 2457T 1078005 NP_837202.1 CDS ppsA NC_004741.1 1598272 1600650 D catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1598272..1600650 Shigella flexneri 2a str. 2457T 1078033 NP_837203.1 CDS ydiD NC_004741.1 1600707 1602407 R acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase complement(1600707..1602407) Shigella flexneri 2a str. 2457T 1078007 NP_837204.1 CDS ydiT NC_004741.1 1602410 1602703 R residues 1 to 97 of 97 are 95.87 pct identical to residues 1 to 97 of 97 from Escherichia coli K-12 : B1700; hypothetical protein complement(1602410..1602703) Shigella flexneri 2a str. 2457T 1078009 NP_837205.1 CDS ydiS NC_004741.1 1602700 1603989 R residues 1 to 429 of 429 are 91.60 pct identical to residues 1 to 429 of 429 from Escherichia coli K-12 : B1699; hypothetical protein complement(1602700..1603989) Shigella flexneri 2a str. 2457T 1080916 NP_837206.1 CDS ydiR NC_004741.1 1604045 1604983 R May play a role in a redox process; electron transfer flavoprotein subunit YdiR complement(1604045..1604983) Shigella flexneri 2a str. 2457T 1078010 NP_837207.1 CDS ydiQ NC_004741.1 1605003 1605767 R YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; electron transfer flavoprotein YdiQ complement(1605003..1605767) Shigella flexneri 2a str. 2457T 1078011 NP_837208.1 CDS S1652 NC_004741.1 1606086 1606586 D residues 1 to 160 of 166 are 99.37 pct identical to residues 1 to 160 of 303 from Escherichia coli K-12 : B1696; ARAC-type regulatory protein 1606086..1606586 Shigella flexneri 2a str. 2457T 1078048 NP_837209.1 CDS S1653 NC_004741.1 1607022 1607315 D residues 1 to 97 of 97 are 81.44 pct identical to residues 35 to 131 of 131 from GenPept : >gb|AAL72404.1| (AF386526) transposase [Shigella flexneri 2a]; partial; IS1 1607022..1607315 Shigella flexneri 2a str. 2457T 1078014 NP_837210.1 CDS S1654 NC_004741.1 1607878 1608639 R regulates the cellular response to acid resistance; transcriptional regulator YdeO complement(1607878..1608639) Shigella flexneri 2a str. 2457T 1077977 NP_837211.1 CDS S1655 NC_004741.1 1608707 1608910 R residues 1 to 64 of 67 are 79.68 pct identical to residues 1 to 64 of 65 from Escherichia coli K-12 : B1500; hypothetical protein complement(1608707..1608910) Shigella flexneri 2a str. 2457T 1078015 NP_837212.1 CDS S1656 NC_004741.1 1609158 1611437 R in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; oxidoreductase complement(1609158..1611437) Shigella flexneri 2a str. 2457T 1077899 NP_837213.1 CDS S1658 NC_004741.1 1612576 1612851 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1612576..1612851 Shigella flexneri 2a str. 2457T 1078017 NP_837214.1 CDS S1659 NC_004741.1 1612770 1613273 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1612770..1613273 Shigella flexneri 2a str. 2457T 1080949 NP_837215.1 CDS S1660 NC_004741.1 1613481 1614194 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 1613481..1614194 Shigella flexneri 2a str. 2457T 1078194 NP_837216.1 CDS S1661 NC_004741.1 1614219 1614398 R residues 1 to 59 of 59 are 67.79 pct identical to residues 1 to 59 of 71 from GenPept : >emb|CAC12891.1| (AJ279086) S protein [Shigella sonnei bacteriophage 7888]; lysis protein S of prophage CP-933V complement(1614219..1614398) Shigella flexneri 2a str. 2457T 1078019 NP_837217.1 CDS S4818 NC_004741.1 1614706 1614909 R residues 1 to 67 of 67 are 99.00 pct identical to residues 1 to 66 of 66 from NRprotein_Feb03 : >ref|NP_753340.1| Hypothetical protein [Escherichia coli CFT073] gb|AAN79900.1|AE016759_174 Hypothetical protein [Escherichia coli CFT073]; hypothetical protein complement(1614706..1614909) Shigella flexneri 2a str. 2457T 1078020 NP_837218.1 CDS rus NC_004741.1 1617635 1617991 R residues 5 to 113 of 118 are 40.36 pct identical to residues 6 to 114 of 120 from Escherichia coli K-12 : B0550; endodeoxyribonuclease RUS (Holliday junction resolvase) complement(1617635..1617991) Shigella flexneri 2a str. 2457T 1078022 NP_837219.1 CDS rem NC_004741.1 1619400 1619648 R residues 1 to 82 of 82 are 93.90 pct identical to residues 2 to 83 of 83 from Escherichia coli K-12 : B1561; hypothetical protein complement(1619400..1619648) Shigella flexneri 2a str. 2457T 1080999 NP_837220.1 CDS relF NC_004741.1 1619869 1620024 R residues 1 to 51 of 51 are 100.00 pct identical to residues 1 to 51 of 51 from Escherichia coli K-12 : B1562; prophage maintenance protein complement(1619869..1620024) Shigella flexneri 2a str. 2457T 1078024 NP_837221.1 CDS relE NC_004741.1 1620096 1620383 R residues 1 to 95 of 95 are 100.00 pct identical to residues 1 to 95 of 95 from Escherichia coli K-12 : B1563; hypothetical protein complement(1620096..1620383) Shigella flexneri 2a str. 2457T 1078018 NP_837222.1 CDS relB NC_004741.1 1620383 1620622 R Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor; bifunctional antitoxin/transcriptional repressor RelB complement(1620383..1620622) Shigella flexneri 2a str. 2457T 1078025 NP_837223.1 CDS b4285 NC_004741.1 1620682 1621308 R residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB complement(1620682..1621308) Shigella flexneri 2a str. 2457T 1078028 NP_837224.1 CDS S1673 NC_004741.1 1621548 1621850 R residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA complement(1621548..1621850) Shigella flexneri 2a str. 2457T 1078032 NP_837225.1 CDS S1675 NC_004741.1 1622201 1622914 R residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB complement(1622201..1622914) Shigella flexneri 2a str. 2457T 1078034 NP_837226.1 CDS S1676 NC_004741.1 1623055 1623357 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA complement(1623055..1623357) Shigella flexneri 2a str. 2457T 1078055 NP_837227.1 CDS ydfI NC_004741.1 1624527 1625987 D residues 1 to 486 of 486 are 98.35 pct identical to residues 1 to 486 of 486 from Escherichia coli K-12 : B1542; oxidoreductase 1624527..1625987 Shigella flexneri 2a str. 2457T 1078068 NP_837228.1 CDS S1679 NC_004741.1 1626023 1626226 R residues 1 to 67 of 67 are 100.00 pct identical to residues 1 to 67 of 67 from Escherichia coli K-12 : B1541; hypothetical protein complement(1626023..1626226) Shigella flexneri 2a str. 2457T 1078049 NP_837229.1 CDS ydfH NC_004741.1 1626404 1627090 R residues 1 to 228 of 228 are 100.00 pct identical to residues 1 to 228 of 228 from Escherichia coli K-12 : B1540; hypothetical protein complement(1626404..1627090) Shigella flexneri 2a str. 2457T 1078036 NP_837230.1 CDS ydfG NC_004741.1 1627179 1627925 R NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase complement(1627179..1627925) Shigella flexneri 2a str. 2457T 1076528 NP_837231.1 CDS dcp NC_004741.1 1628062 1630107 D residues 1 to 681 of 681 are 94.71 pct identical to residues 1 to 681 of 681 from Escherichia coli K-12 : B1538; dipeptidyl carboxypeptidase II 1628062..1630107 Shigella flexneri 2a str. 2457T 1078037 NP_837232.1 CDS ydeJ NC_004741.1 1630152 1630670 R residues 1 to 154 of 172 are 86.36 pct identical to residues 1 to 154 of 172 from Escherichia coli K-12 : B1537; competence damage-inducible protein A complement(1630152..1630670) Shigella flexneri 2a str. 2457T 1078012 NP_837233.1 CDS ydeI NC_004741.1 1630946 1631179 D residues 1 to 75 of 77 are 97.33 pct identical to residues 1 to 75 of 130 from Escherichia coli K-12 : B1536; hypothetical protein 1630946..1631179 Shigella flexneri 2a str. 2457T 1078041 NP_837234.1 CDS S1685 NC_004741.1 1631236 1631538 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 1631236..1631538 Shigella flexneri 2a str. 2457T 1080479 NP_837235.1 CDS S1686 NC_004741.1 1631679 1632392 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 1631679..1632392 Shigella flexneri 2a str. 2457T 1078042 NP_837236.1 CDS ydeF NC_004741.1 1632862 1633980 R residues 2 to 372 of 372 are 95.41 pct identical to residues 25 to 395 of 395 from Escherichia coli K-12 : B1534; transporter complement(1632862..1633980) Shigella flexneri 2a str. 2457T 1078043 NP_837237.2 CDS ydeD NC_004741.1 1634244 1635143 D residues 1 to 266 of 266 are 98.87 pct identical to residues 1 to 266 of 266 from Escherichia coli K-12 : B1533; O-acetylserine/cysteine export protein 1634244..1635143 Shigella flexneri 2a str. 2457T 1078044 NP_837238.1 CDS marB NC_004741.1 1635174 1635392 R residues 1 to 72 of 72 are 62.50 pct identical to residues 1 to 72 of 72 from Escherichia coli K-12 : B1532; hypothetical protein complement(1635174..1635392) Shigella flexneri 2a str. 2457T 1078635 NP_837239.1 CDS marA NC_004741.1 1635424 1635807 R transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA complement(1635424..1635807) Shigella flexneri 2a str. 2457T 1078046 NP_837240.2 CDS marR NC_004741.1 1635827 1636261 R Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR complement(1635827..1636261) Shigella flexneri 2a str. 2457T 1077964 NP_837241.1 CDS ydeB NC_004741.1 1636473 1637138 D protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1636473..1637138 Shigella flexneri 2a str. 2457T 1078050 NP_837242.1 CDS ydeA NC_004741.1 1637163 1638353 R residues 1 to 396 of 396 are 87.12 pct identical to residues 1 to 396 of 396 from Escherichia coli K-12 : B1528; sugar efflux transporter complement(1637163..1638353) Shigella flexneri 2a str. 2457T 1078244 NP_837243.1 CDS S1694 NC_004741.1 1638503 1639618 R residues 1 to 371 of 371 are 96.76 pct identical to residues 1 to 371 of 371 from Escherichia coli K-12 : B1527; hypothetical protein complement(1638503..1639618) Shigella flexneri 2a str. 2457T 1078052 NP_837244.1 CDS yneH NC_004741.1 1640697 1641623 D catalyzes the formation of glutamate from glutamine; glutaminase 1640697..1641623 Shigella flexneri 2a str. 2457T 1078061 NP_837245.1 CDS S1697 NC_004741.1 1641623 1641967 D residues 1 to 114 of 114 are 85.96 pct identical to residues 1 to 114 of 119 from Escherichia coli K-12 : B1523; hypothetical protein 1641623..1641967 Shigella flexneri 2a str. 2457T 1078057 NP_837246.1 CDS S1698 NC_004741.1 1642592 1643539 D residues 11 to 325 of 325 are 92.69 pct identical to residues 1 to 315 of 315 from Escherichia coli K-12 : B1522; hypothetical protein 1642592..1643539 Shigella flexneri 2a str. 2457T 1076937 NP_837247.1 CDS uxaB NC_004741.1 1643766 1645217 D catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1643766..1645217 Shigella flexneri 2a str. 2457T 1078058 NP_837248.1 CDS S1701 NC_004741.1 1647060 1648025 D residues 1 to 321 of 321 are 99.68 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B1520; hypothetical protein 1647060..1648025 Shigella flexneri 2a str. 2457T 1078745 NP_837249.1 CDS S1702 NC_004741.1 1648029 1648787 R catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase complement(1648029..1648787) Shigella flexneri 2a str. 2457T 1078059 NP_837250.1 CDS S1703 NC_004741.1 1648827 1649117 R residues 1 to 96 of 96 are 98.95 pct identical to residues 1 to 96 of 96 from Escherichia coli K-12 : B1518; autoinducer-2 (AI-2) modifying protein LsrG complement(1648827..1649117) Shigella flexneri 2a str. 2457T 1078060 NP_837251.1 CDS S1704 NC_004741.1 1649141 1649923 R residues 1 to 260 of 260 are 98.46 pct identical to residues 32 to 291 of 291 from Escherichia coli K-12 : B1517; part of yneB; aldolase complement(1649141..1649923) Shigella flexneri 2a str. 2457T 1078175 NP_837252.2 CDS S1705 NC_004741.1 1649936 1650841 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(1649936..1650841) Shigella flexneri 2a str. 2457T 1080940 NP_837253.2 CDS S1706 NC_004741.1 1650799 1651164 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(1650799..1651164) Shigella flexneri 2a str. 2457T 1078062 NP_837254.1 CDS ydeW NC_004741.1 1652321 1653274 R residues 1 to 317 of 317 are 89.90 pct identical to residues 1 to 317 of 317 from Escherichia coli K-12 : B1512; sorC family transcriptional regulator complement(1652321..1653274) Shigella flexneri 2a str. 2457T 1078072 NP_837255.1 CDS S1709 NC_004741.1 1653523 1655058 D residues 1 to 511 of 511 are 98.43 pct identical to residues 1 to 511 of 511 from Escherichia coli K-12 : B1513; ATP-binding component of a transport system 1653523..1655058 Shigella flexneri 2a str. 2457T 1078065 NP_837256.1 CDS ydeY NC_004741.1 1655052 1656080 D residues 1 to 342 of 342 are 83.62 pct identical to residues 1 to 342 of 342 from Escherichia coli K-12 : B1514; transport system permease 1655052..1656080 Shigella flexneri 2a str. 2457T 1078066 NP_837257.1 CDS ydeZ NC_004741.1 1656080 1657072 D residues 1 to 330 of 330 are 76.36 pct identical to residues 1 to 330 of 330 from Escherichia coli K-12 : B1515; transport system permease 1656080..1657072 Shigella flexneri 2a str. 2457T 1079017 NP_837258.2 CDS S1714 NC_004741.1 1658322 1658687 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1658322..1658687 Shigella flexneri 2a str. 2457T 1078649 NP_837259.2 CDS S1715 NC_004741.1 1658645 1659550 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1658645..1659550 Shigella flexneri 2a str. 2457T 1078070 NP_837260.1 CDS S1716 NC_004741.1 1659600 1660412 R residues 1 to 270 of 270 are 95.92 pct identical to residues 10 to 279 of 279 from GenPept : >gb|AAG53988.1|AF327445_2 (AF327445) transposase B [Pantoea agglomerans]; ISEhe3 orfB complement(1659600..1660412) Shigella flexneri 2a str. 2457T 1078071 NP_837261.1 CDS S1717 NC_004741.1 1660469 1660747 R residues 1 to 92 of 92 are 92.39 pct identical to residues 3 to 94 of 94 from GenPept : >gb|AAG53987.1|AF327445_1 (AF327445) transposase A [Pantoea agglomerans]; ISEhe3 orfA complement(1660469..1660747) Shigella flexneri 2a str. 2457T 1080569 NP_837262.1 CDS rspA NC_004741.1 1660824 1662038 R residues 1 to 403 of 404 are 99.75 pct identical to residues 1 to 403 of 404 from Escherichia coli K-12 : B1581; starvation sensing protein complement(1660824..1662038) Shigella flexneri 2a str. 2457T 1078073 NP_837263.1 CDS S1719 NC_004741.1 1662244 1662570 R residues 1 to 108 of 108 are 99.07 pct identical to residues 1 to 108 of 108 from Escherichia coli K-12 : B1582; hypothetical protein complement(1662244..1662570) Shigella flexneri 2a str. 2457T 1078267 NP_837264.1 CDS S1720 NC_004741.1 1662705 1663046 D residues 1 to 113 of 113 are 89.38 pct identical to residues 1 to 113 of 113 from Escherichia coli K-12 : B1583; hypothetical protein 1662705..1663046 Shigella flexneri 2a str. 2457T 1078075 NP_837265.2 CDS ynfC NC_004741.1 1663644 1664354 R residues 1 to 248 of 248 are 100.00 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 : B1585; hypothetical protein complement(1663644..1664354) Shigella flexneri 2a str. 2457T 1078076 NP_837266.1 CDS S1723 NC_004741.1 1664462 1664767 D residues 1 to 101 of 101 are 83.16 pct identical to residues 15 to 115 of 115 from Escherichia coli K-12 : B1586; hypothetical protein 1664462..1664767 Shigella flexneri 2a str. 2457T 1078077 NP_837267.1 CDS S1727 NC_004741.1 1667110 1668099 R residues 3 to 327 of 329 are 91.69 pct identical to residues 2 to 326 of 327 from GenPept : >emb|CAD02863.1| (AL627277) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(1667110..1668099) Shigella flexneri 2a str. 2457T 1078947 NP_837268.1 CDS S1728 NC_004741.1 1668186 1668677 R residues 1 to 163 of 163 are 84.66 pct identical to residues 1 to 163 of 163 from GenPept : >emb|CAD02864.1| (AL627277) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(1668186..1668677) Shigella flexneri 2a str. 2457T 1078518 NP_837269.1 CDS S1730 NC_004741.1 1668998 1669498 R no significant similarities; hypothetical protein complement(1668998..1669498) Shigella flexneri 2a str. 2457T 1078082 NP_837270.1 CDS S1731 NC_004741.1 1669488 1670003 R no significant similarities; hypothetical protein complement(1669488..1670003) Shigella flexneri 2a str. 2457T 1078661 NP_837271.1 CDS S1732 NC_004741.1 1670434 1670802 R no significant similarities; hypothetical protein complement(1670434..1670802) Shigella flexneri 2a str. 2457T 1078083 NP_837272.1 CDS S1736 NC_004741.1 1671771 1672397 R residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB complement(1671771..1672397) Shigella flexneri 2a str. 2457T 1079394 NP_837273.1 CDS S1738 NC_004741.1 1672637 1672939 R residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA complement(1672637..1672939) Shigella flexneri 2a str. 2457T 1078084 NP_837274.1 CDS S1739 NC_004741.1 1673009 1673797 R residues 4 to 193 of 262 are 27.77 pct identical to residues 57 to 243 of 548 from GenPept : >emb|CAD02867.1| (AL627277) possible integrase [Salmonella enterica subsp. enterica serovar Typhi]; integrase complement(1673009..1673797) Shigella flexneri 2a str. 2457T 1079680 NP_837275.1 CDS S1742 NC_004741.1 1677248 1677865 D residues 1 to 205 of 205 are 99.51 pct identical to residues 1 to 205 of 205 from Escherichia coli K-12 : B1589; oxidoreductase, Fe-S subunit 1677248..1677865 Shigella flexneri 2a str. 2457T 1078086 NP_837276.1 CDS S1743 NC_004741.1 1677867 1678721 D residues 1 to 284 of 284 are 90.49 pct identical to residues 1 to 284 of 284 from Escherichia coli K-12 : B1590; DMSO reductase anchor subunit 1677867..1678721 Shigella flexneri 2a str. 2457T 1078091 NP_837277.1 CDS S1744 NC_004741.1 1678764 1679378 D binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1678764..1679378 Shigella flexneri 2a str. 2457T 1078074 NP_837278.2 CDS S1745 NC_004741.1 1679573 1680829 D residues 1 to 438 of 438 are 81.05 pct identical to residues 1 to 438 of 438 from Escherichia coli K-12 : B1592; voltage-gated ClC-type chloride channel ClcB 1679573..1680829 Shigella flexneri 2a str. 2457T 1078087 NP_837279.1 CDS bioD NC_004741.1 1680782 1681477 R DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase complement(1680782..1681477) Shigella flexneri 2a str. 2457T 1077932 NP_837280.1 CDS mlc NC_004741.1 1681602 1682822 R residues 1 to 406 of 406 are 99.26 pct identical to residues 1 to 406 of 406 from Escherichia coli K-12 : B1594; NAGC-like transcriptional regulator complement(1681602..1682822) Shigella flexneri 2a str. 2457T 1078093 NP_837281.1 CDS ynfL NC_004741.1 1682957 1683868 R residues 1 to 303 of 303 are 94.71 pct identical to residues 1 to 297 of 297 from Escherichia coli K-12 : B1595; LYSR-type transcriptional regulator complement(1682957..1683868) Shigella flexneri 2a str. 2457T 1077942 NP_837282.2 CDS asr NC_004741.1 1685652 1685960 D required for growth and survival under moderately acid conditions; acid shock protein precursor 1685652..1685960 Shigella flexneri 2a str. 2457T 1076487 NP_837283.1 CDS S1751 NC_004741.1 1686236 1687057 D residues 1 to 273 of 273 are 99.26 pct identical to residues 1 to 273 of 273 from Escherichia coli K-12 : B1598; hypothetical protein 1686236..1687057 Shigella flexneri 2a str. 2457T 1078095 NP_837284.1 CDS S1752 NC_004741.1 1687096 1687425 R with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI complement(1687096..1687425) Shigella flexneri 2a str. 2457T 1078134 NP_837285.1 CDS S1753 NC_004741.1 1687412 1687777 R with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ complement(1687412..1687777) Shigella flexneri 2a str. 2457T 1078097 NP_837286.1 CDS tqsA NC_004741.1 1688188 1689222 D transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transporter 1688188..1689222 Shigella flexneri 2a str. 2457T 1077069 NP_837287.1 CDS pntB NC_004741.1 1689247 1690635 R catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase complement(1689247..1690635) Shigella flexneri 2a str. 2457T 1078098 NP_837288.1 CDS pntA NC_004741.1 1690646 1692193 R forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha complement(1690646..1692193) Shigella flexneri 2a str. 2457T 1078099 NP_837289.1 CDS S1757 NC_004741.1 1692702 1693646 D residues 1 to 314 of 314 are 88.53 pct identical to residues 1 to 314 of 314 from Escherichia coli K-12 : B1604; hypothetical protein 1692702..1693646 Shigella flexneri 2a str. 2457T 1078132 NP_837290.1 CDS S1758 NC_004741.1 1693832 1695214 D residues 1 to 460 of 460 are 95.86 pct identical to residues 1 to 460 of 460 from Escherichia coli K-12 : B1605; arginine/ornithine antiporter 1693832..1695214 Shigella flexneri 2a str. 2457T 1078100 NP_837291.1 CDS ydgB NC_004741.1 1695251 1695973 D residues 1 to 240 of 240 are 92.50 pct identical to residues 1 to 240 of 240 from Escherichia coli K-12 : B1606; short chain dehydrogenase 1695251..1695973 Shigella flexneri 2a str. 2457T 1078448 NP_837292.1 CDS ydgC NC_004741.1 1695970 1696305 R residues 23 to 111 of 111 are 100.00 pct identical to residues 23 to 111 of 111 from Escherichia coli K-12 : B1607; hypothetical protein complement(1695970..1696305) Shigella flexneri 2a str. 2457T 1078101 NP_837293.1 CDS rstA NC_004741.1 1696434 1697177 D response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1696434..1697177 Shigella flexneri 2a str. 2457T 1077974 NP_837294.1 CDS S1762 NC_004741.1 1697675 1698721 D residues 1 to 345 of 348 are 70.43 pct identical to residues 100 to 444 of 448 from GenPept : >emb|CAD01997.1| (AL627271) transporter [Salmonella enterica subsp. enterica serovar Typhi]; transporter 1697675..1698721 Shigella flexneri 2a str. 2457T 1078102 NP_837295.1 CDS rstB NC_004741.1 1698900 1700201 D residues 1 to 433 of 433 are 95.61 pct identical to residues 1 to 433 of 433 from Escherichia coli K-12 : B1609; sensor protein RstB 1698900..1700201 Shigella flexneri 2a str. 2457T 1078026 NP_837296.1 CDS tus NC_004741.1 1700277 1701206 D binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1700277..1701206 Shigella flexneri 2a str. 2457T 1079681 NP_837297.1 CDS fumC NC_004741.1 1701203 1702606 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(1701203..1702606) Shigella flexneri 2a str. 2457T 1078103 NP_837298.1 CDS fumA NC_004741.1 1702749 1704395 R residues 1 to 548 of 548 are 99.63 pct identical to residues 1 to 548 of 548 from Escherichia coli K-12 : B1612; fumarase A, fumarate hydratase class I; aerobic isozyme complement(1702749..1704395) Shigella flexneri 2a str. 2457T 1078104 NP_837299.1 CDS manA NC_004741.1 1704594 1705769 D residues 1 to 391 of 391 are 99.48 pct identical to residues 1 to 391 of 391 from Escherichia coli K-12 : B1613; mannose-6-phosphate isomerase 1704594..1705769 Shigella flexneri 2a str. 2457T 1078039 NP_837300.1 CDS ydgA NC_004741.1 1705870 1707345 D residues 1 to 487 of 491 are 93.83 pct identical to residues 1 to 487 of 502 from Escherichia coli K-12 : B1614; hypothetical protein 1705870..1707345 Shigella flexneri 2a str. 2457T 1078106 NP_837301.2 CDS uidC NC_004741.1 1707605 1708870 R residues 1 to 415 of 415 are 98.55 pct identical to residues 3 to 417 of 417 from Escherichia coli K-12 : B1615; outer membrane porin protein complement(1707605..1708870) Shigella flexneri 2a str. 2457T 1078107 NP_837302.1 CDS uidA NC_004741.1 1709940 1711643 R residues 1 to 566 of 567 are 99.46 pct identical to residues 1 to 566 of 603 from Escherichia coli K-12 : B1617; beta-D-glucuronidase complement(1709940..1711643) Shigella flexneri 2a str. 2457T 1078109 NP_837303.1 CDS uidR NC_004741.1 1712031 1712621 R residues 1 to 196 of 196 are 100.00 pct identical to residues 1 to 196 of 196 from Escherichia coli K-12 : B1618; repressor for uid operon complement(1712031..1712621) Shigella flexneri 2a str. 2457T 1078111 NP_837304.1 CDS S1774 NC_004741.1 1713026 1713529 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(1713026..1713529) Shigella flexneri 2a str. 2457T 1078116 NP_837305.1 CDS S1775 NC_004741.1 1713448 1713723 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1713448..1713723) Shigella flexneri 2a str. 2457T 1078533 NP_837306.1 CDS malI NC_004741.1 1714506 1715534 R regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI complement(1714506..1715534) Shigella flexneri 2a str. 2457T 1078117 NP_837307.1 CDS malX NC_004741.1 1715709 1717301 D phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional maltose and glucose-specific PTS system components IICB 1715709..1717301 Shigella flexneri 2a str. 2457T 1080903 NP_837308.1 CDS malY NC_004741.1 1717311 1718483 D residues 1 to 390 of 390 are 98.71 pct identical to residues 1 to 390 of 390 from Escherichia coli K-12 : B1622; cystathionine beta-lyase; maltose regulon modulator 1717311..1718483 Shigella flexneri 2a str. 2457T 1078118 NP_837309.1 CDS add NC_004741.1 1718587 1719588 D catalyzes the formation of inosine from adenosine; adenosine deaminase 1718587..1719588 Shigella flexneri 2a str. 2457T 1078119 NP_837310.2 CDS S1781 NC_004741.1 1719624 1720664 R residues 1 to 359 of 359 are 94.42 pct identical to residues 1 to 359 of 359 from Escherichia coli K-12 : B1624; oxidoreductase complement(1719624..1720664) Shigella flexneri 2a str. 2457T 1078198 NP_837311.1 CDS S1782 NC_004741.1 1721305 1721520 D YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1721305..1721520 Shigella flexneri 2a str. 2457T 1078120 NP_837312.1 CDS S1783 NC_004741.1 1721606 1722046 D residues 1 to 146 of 146 are 79.45 pct identical to residues 9 to 154 of 154 from Escherichia coli K-12 : B1626; hypothetical protein 1721606..1722046 Shigella flexneri 2a str. 2457T 1078122 NP_837313.1 CDS S1784 NC_004741.1 1722123 1722704 D residues 1 to 193 of 193 are 92.22 pct identical to residues 1 to 193 of 193 from Escherichia coli K-12 : B1627; Na(+)-translocating NADH-quinone reductase subunit E 1722123..1722704 Shigella flexneri 2a str. 2457T 1078123 NP_837314.1 CDS S1785 NC_004741.1 1722704 1723282 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1722704..1723282 Shigella flexneri 2a str. 2457T 1078124 NP_837315.1 CDS S1786 NC_004741.1 1723275 1725497 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1723275..1725497 Shigella flexneri 2a str. 2457T 1079775 NP_837316.1 CDS rnfD NC_004741.1 1725498 1726556 D RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1725498..1726556 Shigella flexneri 2a str. 2457T 1078125 NP_837317.1 CDS S1788 NC_004741.1 1726560 1727180 D part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1726560..1727180 Shigella flexneri 2a str. 2457T 1079417 NP_837318.1 CDS ydgQ NC_004741.1 1727184 1727879 D in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 1727184..1727879 Shigella flexneri 2a str. 2457T 1078126 NP_837319.1 CDS nth NC_004741.1 1727879 1728514 D DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1727879..1728514 Shigella flexneri 2a str. 2457T 1078128 NP_837320.1 CDS tppB NC_004741.1 1729125 1730627 D mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 1729125..1730627 Shigella flexneri 2a str. 2457T 1078129 NP_837321.1 CDS gst NC_004741.1 1730733 1731338 D residues 1 to 201 of 201 are 93.03 pct identical to residues 1 to 201 of 201 from Escherichia coli K-12 : B1635; glutathionine S-transferase 1730733..1731338 Shigella flexneri 2a str. 2457T 1080553 NP_837322.1 CDS pdxY NC_004741.1 1731382 1732245 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase complement(1731382..1732245) Shigella flexneri 2a str. 2457T 1078130 NP_837323.1 CDS tyrS NC_004741.1 1732304 1733578 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(1732304..1733578) Shigella flexneri 2a str. 2457T 1078131 NP_837324.1 CDS pdxH NC_004741.1 1733707 1734363 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(1733707..1734363) Shigella flexneri 2a str. 2457T 1078135 NP_837325.1 CDS ydhA NC_004741.1 1734422 1734670 R residues 1 to 82 of 82 are 96.34 pct identical to residues 1 to 82 of 82 from Escherichia coli K-12 : B1639; hypothetical protein complement(1734422..1734670) Shigella flexneri 2a str. 2457T 1078137 NP_837326.2 CDS S1797 NC_004741.1 1734692 1735597 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(1734692..1735597) Shigella flexneri 2a str. 2457T 1078140 NP_837327.2 CDS S1798 NC_004741.1 1735555 1735920 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(1735555..1735920) Shigella flexneri 2a str. 2457T 1078141 NP_837328.1 CDS anmK NC_004741.1 1736185 1737294 R catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase complement(1736185..1737294) Shigella flexneri 2a str. 2457T 1078133 NP_837329.1 CDS slyB NC_004741.1 1737568 1738035 D residues 1 to 155 of 155 are 65.16 pct identical to residues 1 to 155 of 155 from Escherichia coli K-12 : B1641; outer membrane protein 1737568..1738035 Shigella flexneri 2a str. 2457T 1078143 NP_837330.2 CDS slyA NC_004741.1 1738082 1738516 R Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA complement(1738082..1738516) Shigella flexneri 2a str. 2457T 1077305 NP_837331.1 CDS S1802 NC_004741.1 1738717 1738953 D residues 1 to 78 of 78 are 84.61 pct identical to residues 1 to 78 of 78 from Escherichia coli K-12 : B1643; hypothetical protein 1738717..1738953 Shigella flexneri 2a str. 2457T 1078144 NP_837332.1 CDS S1803 NC_004741.1 1738947 1739813 D residues 1 to 288 of 288 are 97.56 pct identical to residues 12 to 299 of 299 from Escherichia coli K-12 : B1644; hypothetical protein 1738947..1739813 Shigella flexneri 2a str. 2457T 1079324 NP_837333.1 CDS sodC NC_004741.1 1741826 1742362 R SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase complement(1741826..1742362) Shigella flexneri 2a str. 2457T 1079362 NP_837334.1 CDS S1806 NC_004741.1 1742428 1743324 R residues 1 to 298 of 298 are 93.95 pct identical to residues 1 to 298 of 298 from Escherichia coli K-12 : B1647; hypothetical protein complement(1742428..1743324) Shigella flexneri 2a str. 2457T 1078146 NP_837335.1 CDS S1808 NC_004741.1 1743373 1743750 R residues 1 to 125 of 125 are 100.00 pct identical to residues 1 to 125 of 125 from Escherichia coli K-12 : B1648; hypothetical protein complement(1743373..1743750) Shigella flexneri 2a str. 2457T 1078180 NP_837336.1 CDS S1807 NC_004741.1 1743715 1744314 D residues 1 to 199 of 199 are 99.49 pct identical to residues 1 to 199 of 199 from Escherichia coli K-12 : B1649; hypothetical protein 1743715..1744314 Shigella flexneri 2a str. 2457T 1078148 NP_837337.1 CDS nemA NC_004741.1 1744351 1745448 D FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1744351..1745448 Shigella flexneri 2a str. 2457T 1078459 NP_837338.1 CDS gloA NC_004741.1 1745529 1745936 D Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1745529..1745936 Shigella flexneri 2a str. 2457T 1078150 NP_837339.1 CDS rnt NC_004741.1 1746039 1746686 D Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1746039..1746686 Shigella flexneri 2a str. 2457T 1078069 NP_837340.1 CDS S1813 NC_004741.1 1751281 1752429 R residues 1 to 382 of 382 are 96.85 pct identical to residues 21 to 402 of 402 from Escherichia coli K-12 : B1432; virulence protein complement(1751281..1752429) Shigella flexneri 2a str. 2457T 1078527 NP_837341.1 CDS ydhD NC_004741.1 1753036 1753383 R residues 1 to 115 of 115 are 100.00 pct identical to residues 1 to 115 of 115 from Escherichia coli K-12 : B1654; hypothetical protein complement(1753036..1753383) Shigella flexneri 2a str. 2457T 1078152 NP_837342.1 CDS ydhO NC_004741.1 1753718 1754545 D residues 1 to 275 of 275 are 79.63 pct identical to residues 1 to 271 of 271 from Escherichia coli K-12 : B1655; lipoprotein 1753718..1754545 Shigella flexneri 2a str. 2457T 1078154 NP_837343.1 CDS sodB NC_004741.1 1754673 1755254 D SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1754673..1755254 Shigella flexneri 2a str. 2457T 1079354 NP_837344.1 CDS S1817 NC_004741.1 1755400 1756569 R residues 1 to 389 of 389 are 86.63 pct identical to residues 1 to 389 of 389 from Escherichia coli K-12 : B1657; transporter complement(1755400..1756569) Shigella flexneri 2a str. 2457T 1078155 NP_837345.1 CDS purR NC_004741.1 1757123 1758148 D binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1757123..1758148 Shigella flexneri 2a str. 2457T 1078157 NP_837346.1 CDS ydhB NC_004741.1 1758145 1759077 R residues 1 to 310 of 310 are 99.35 pct identical to residues 1 to 310 of 310 from Escherichia coli K-12 : B1659; DNA-binding transcriptional regulator complement(1758145..1759077) Shigella flexneri 2a str. 2457T 1079785 NP_837347.1 CDS ydhC NC_004741.1 1759190 1760401 D uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1759190..1760401 Shigella flexneri 2a str. 2457T 1078158 NP_837348.1 CDS cfa NC_004741.1 1760692 1761840 D catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane-fatty-acyl-phospholipid synthase 1760692..1761840 Shigella flexneri 2a str. 2457T 1080927 NP_837349.1 CDS ribE NC_004741.1 1761880 1762521 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(1761880..1762521) Shigella flexneri 2a str. 2457T 1078160 NP_837350.1 CDS ydhE NC_004741.1 1762736 1764109 D NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1762736..1764109 Shigella flexneri 2a str. 2457T 1079330 NP_837351.1 CDS S1824 NC_004741.1 1764150 1765406 R residues 1 to 418 of 418 are 98.56 pct identical to residues 1 to 418 of 418 from Escherichia coli K-12 : B1664; hypothetical protein complement(1764150..1765406) Shigella flexneri 2a str. 2457T 1078161 NP_837352.1 CDS S1827 NC_004741.1 1765979 1766284 D residues 1 to 101 of 101 are 100.00 pct identical to residues 1 to 101 of 101 from Escherichia coli K-12 : B1667; hypothetical protein 1765979..1766284 Shigella flexneri 2a str. 2457T 1078163 NP_837353.1 CDS S1829 NC_004741.1 1767844 1768656 R residues 1 to 270 of 270 are 92.96 pct identical to residues 1 to 270 of 270 from Escherichia coli K-12 : B1669; hypothetical protein complement(1767844..1768656) Shigella flexneri 2a str. 2457T 1078164 NP_837354.1 CDS ydhU NC_004741.1 1768660 1769445 R residues 1 to 261 of 261 are 80.45 pct identical to residues 1 to 261 of 261 from Escherichia coli K-12 : B1670; hypothetical protein complement(1768660..1769445) Shigella flexneri 2a str. 2457T 1078165 NP_837355.1 CDS S1831 NC_004741.1 1769442 1770161 R residues 1 to 239 of 239 are 98.74 pct identical to residues 1 to 239 of 239 from Escherichia coli K-12 : B1671; oxidoreductase, Fe-S subunit complement(1769442..1770161) Shigella flexneri 2a str. 2457T 1078166 NP_837356.1 CDS S1832 NC_004741.1 1770174 1770812 R residues 1 to 212 of 212 are 87.26 pct identical to residues 4 to 215 of 215 from Escherichia coli K-12 : B1672; hypothetical protein complement(1770174..1770812) Shigella flexneri 2a str. 2457T 1078172 NP_837357.1 CDS S1834 NC_004741.1 1772947 1773573 R residues 1 to 208 of 208 are 91.82 pct identical to residues 1 to 208 of 208 from Escherichia coli K-12 : B1674; hypothetical protein complement(1772947..1773573) Shigella flexneri 2a str. 2457T 1078173 NP_837358.1 CDS S1835 NC_004741.1 1774029 1774238 R residues 1 to 69 of 69 are 100.00 pct identical to residues 1 to 69 of 69 from Escherichia coli K-12 : B1675; hypothetical protein complement(1774029..1774238) Shigella flexneri 2a str. 2457T 1078168 NP_837359.1 CDS S1836 NC_004741.1 1774325 1774600 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1774325..1774600 Shigella flexneri 2a str. 2457T 1078169 NP_837360.1 CDS S1837 NC_004741.1 1774519 1775022 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1774519..1775022 Shigella flexneri 2a str. 2457T 1077564 NP_837361.1 CDS pykF NC_004741.1 1775571 1776983 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1775571..1776983 Shigella flexneri 2a str. 2457T 1078170 NP_837362.1 CDS lpp NC_004741.1 1777294 1777530 D residues 1 to 78 of 78 are 100.00 pct identical to residues 1 to 78 of 78 from Escherichia coli K-12 : B1677; murein lipoprotein 1777294..1777530 Shigella flexneri 2a str. 2457T 1079288 NP_837363.1 CDS ynhG NC_004741.1 1777593 1778597 R residues 1 to 334 of 334 are 99.70 pct identical to residues 1 to 334 of 334 from Escherichia coli K-12 : B1678; hypothetical protein complement(1777593..1778597) Shigella flexneri 2a str. 2457T 1078171 NP_837364.1 CDS ynhA NC_004741.1 1778746 1779162 R Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE complement(1778746..1779162) Shigella flexneri 2a str. 2457T 1077573 NP_837365.1 CDS S1842 NC_004741.1 1779175 1780395 R catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase complement(1779175..1780395) Shigella flexneri 2a str. 2457T 1078174 NP_837366.1 CDS ynhC NC_004741.1 1780392 1781663 R with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD complement(1780392..1781663) Shigella flexneri 2a str. 2457T 1078176 NP_837367.1 CDS sufC NC_004741.1 1781638 1782384 R part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase complement(1781638..1782384) Shigella flexneri 2a str. 2457T 1078186 NP_837368.1 CDS ynhE NC_004741.1 1782394 1783881 R with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB complement(1782394..1783881) Shigella flexneri 2a str. 2457T 1078177 NP_837369.1 CDS sufA NC_004741.1 1783890 1784258 R functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein complement(1783890..1784258) Shigella flexneri 2a str. 2457T 1078178 NP_837370.1 CDS S1847 NC_004741.1 1784806 1785075 R residues 1 to 89 of 89 are 100.00 pct identical to residues 1 to 89 of 89 from Escherichia coli K-12 : B1685; hypothetical protein complement(1784806..1785075) Shigella flexneri 2a str. 2457T 1078179 NP_837371.1 CDS S1848 NC_004741.1 1785094 1785504 R residues 1 to 136 of 136 are 99.26 pct identical to residues 1 to 136 of 136 from Escherichia coli K-12 : B1686; hypothetical protein complement(1785094..1785504) Shigella flexneri 2a str. 2457T 1078181 NP_837372.1 CDS ydiJ NC_004741.1 1785501 1788557 R residues 1 to 1018 of 1018 are 97.54 pct identical to residues 1 to 1018 of 1018 from Escherichia coli K-12 : B1687; oxidase complement(1785501..1788557) Shigella flexneri 2a str. 2457T 1078426 NP_837373.1 CDS S1850 NC_004741.1 1788946 1790058 D YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; inner membrane protein 1788946..1790058 Shigella flexneri 2a str. 2457T 1078184 NP_837374.1 CDS S1851 NC_004741.1 1790487 1790843 D residues 1 to 118 of 118 are 98.30 pct identical to residues 10 to 127 of 127 from Escherichia coli K-12 : B1689; hypothetical protein 1790487..1790843 Shigella flexneri 2a str. 2457T 1078183 NP_837375.1 CDS S1852 NC_004741.1 1791003 1792148 D residues 1 to 381 of 381 are 98.43 pct identical to residues 21 to 404 of 404 from Escherichia coli K-12 : B1690; transport system permease 1791003..1792148 Shigella flexneri 2a str. 2457T 1079788 NP_837376.1 CDS S1853 NC_004741.1 1792442 1793602 D residues 1 to 386 of 386 are 91.19 pct identical to residues 38 to 423 of 423 from Escherichia coli K-12 : B1691; amino acid/amine transport protein 1792442..1793602 Shigella flexneri 2a str. 2457T 1078185 NP_837377.1 CDS aroE NC_004741.1 1793614 1794480 D YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1793614..1794480 Shigella flexneri 2a str. 2457T 1079284 NP_837378.1 CDS aroD NC_004741.1 1794511 1795269 D catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1794511..1795269 Shigella flexneri 2a str. 2457T 1078189 NP_837379.1 CDS S1857 NC_004741.1 1795351 1795854 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(1795351..1795854) Shigella flexneri 2a str. 2457T 1078190 NP_837380.1 CDS S1856 NC_004741.1 1795773 1796048 R residues 49 to 88 of 88 are 97.50 pct identical to residues 1 to 40 of 100 from GenPept : >gb|AAL72519.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS1 orfA complement(1795773..1796048) Shigella flexneri 2a str. 2457T 1078191 NP_837381.1 CDS S1859 NC_004741.1 1797701 1798858 D residues 1 to 385 of 385 are 99.22 pct identical to residues 6 to 390 of 390 from Escherichia coli K-12 : B1497; enzyme 1797701..1798858 Shigella flexneri 2a str. 2457T 1078263 NP_837382.1 CDS yddB NC_004741.1 1800872 1803232 D residues 1 to 786 of 786 are 97.97 pct identical to residues 1 to 790 of 790 from Escherichia coli K-12 : B1495; hypothetical protein 1800872..1803232 Shigella flexneri 2a str. 2457T 1078195 NP_837383.1 CDS S1862 NC_004741.1 1803502 1804005 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(1803502..1804005) Shigella flexneri 2a str. 2457T 1078090 NP_837384.1 CDS S1863 NC_004741.1 1803924 1804199 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1803924..1804199) Shigella flexneri 2a str. 2457T 1078197 NP_837385.1 CDS S1865 NC_004741.1 1806810 1807085 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1806810..1807085 Shigella flexneri 2a str. 2457T 1080531 NP_837386.1 CDS S1866 NC_004741.1 1807004 1807507 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1807004..1807507 Shigella flexneri 2a str. 2457T 1078663 NP_837387.1 CDS gadB NC_004741.1 1807985 1809385 D residues 1 to 466 of 466 are 100.00 pct identical to residues 1 to 466 of 466 from Escherichia coli K-12 : B1493; glutamate decarboxylase 1807985..1809385 Shigella flexneri 2a str. 2457T 1078199 NP_837388.1 CDS xasA NC_004741.1 1809541 1811076 D residues 1 to 511 of 511 are 87.27 pct identical to residues 1 to 511 of 511 from Escherichia coli K-12 : B1492; acid sensitivity protein, transporter 1809541..1811076 Shigella flexneri 2a str. 2457T 1078202 NP_837389.1 CDS S1869 NC_004741.1 1811207 1812526 D residues 1 to 439 of 439 are 100.00 pct identical to residues 1 to 439 of 439 from Escherichia coli K-12 : B1491; hypothetical protein 1811207..1812526 Shigella flexneri 2a str. 2457T 1079979 NP_837390.1 CDS S1873 NC_004741.1 1815194 1816090 D residues 1 to 298 of 298 are 90.26 pct identical to residues 1 to 298 of 298 from Escherichia coli K-12 : B1485; ATP-dependent peptide transporter membrane subunit 1815194..1816090 Shigella flexneri 2a str. 2457T 1078205 NP_837391.1 CDS S1874 NC_004741.1 1816087 1817073 D residues 1 to 328 of 328 are 97.86 pct identical to residues 1 to 328 of 328 from Escherichia coli K-12 : B1484; ATP-binding component of a transport system 1816087..1817073 Shigella flexneri 2a str. 2457T 1080933 NP_837392.1 CDS osmC NC_004741.1 1818048 1818479 R residues 1 to 143 of 143 are 100.00 pct identical to residues 1 to 143 of 143 from Escherichia coli K-12 : B1482; osmotically inducible protein complement(1818048..1818479) Shigella flexneri 2a str. 2457T 1078207 NP_837393.1 CDS S1877 NC_004741.1 1818652 1819155 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(1818652..1819155) Shigella flexneri 2a str. 2457T 1078209 NP_837394.1 CDS S1878 NC_004741.1 1819074 1819349 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1819074..1819349) Shigella flexneri 2a str. 2457T 1078114 NP_837395.1 CDS sfcA NC_004741.1 1819537 1821234 D malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1819537..1821234 Shigella flexneri 2a str. 2457T 1078212 NP_837396.1 CDS adhP NC_004741.1 1821368 1822378 D similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 1821368..1822378 Shigella flexneri 2a str. 2457T 1078211 NP_837397.1 CDS yddM NC_004741.1 1822446 1822808 D residues 1 to 120 of 120 are 89.99 pct identical to residues 1 to 120 of 120 from Escherichia coli K-12 : B1477; hypothetical protein 1822446..1822808 Shigella flexneri 2a str. 2457T 1078217 NP_837398.1 CDS fdnI NC_004741.1 1823036 1823689 R nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma complement(1823036..1823689) Shigella flexneri 2a str. 2457T 1078218 NP_837399.1 CDS fdnH NC_004741.1 1823682 1824566 R residues 1 to 283 of 294 are 100.00 pct identical to residues 1 to 283 of 294 from Escherichia coli K-12 : B1475; formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit complement(1823682..1824566) Shigella flexneri 2a str. 2457T 1078136 NP_837400.1 CDS fdnG NC_004741.1 1824579 1827626 R residues 1 to 1015 of 1015 are 99.21 pct identical to residues 1 to 1015 of 1015 from Escherichia coli K-12 : B1474; selenocysteine; formate dehydrogenase-N, nitrate-inducible, alpha subunit complement(1824579..1827626) Shigella flexneri 2a str. 2457T 1078219 NP_837401.1 CDS yddG NC_004741.1 1827858 1828739 D residues 1 to 293 of 293 are 90.78 pct identical to residues 1 to 293 of 293 from Escherichia coli K-12 : B1473; hypothetical protein 1827858..1828739 Shigella flexneri 2a str. 2457T 1078220 NP_837402.1 CDS S1887 NC_004741.1 1828994 1830094 D residues 1 to 93 of 364 are 100.00 pct identical to residues 1 to 93 of 96 from Escherichia coli K-12 : B1472; outer membrane porin protein 1828994..1830094 Shigella flexneri 2a str. 2457T 1078088 NP_837403.1 CDS S1888 NC_004741.1 1830853 1831842 D residues 1 to 317 of 329 are 92.42 pct identical to residues 1 to 317 of 318 from Escherichia coli K-12 : B1471; glycoprotein 1830853..1831842 Shigella flexneri 2a str. 2457T 1078222 NP_837404.1 CDS S1890 NC_004741.1 1832130 1832405 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1832130..1832405 Shigella flexneri 2a str. 2457T 1078223 NP_837405.1 CDS S1891 NC_004741.1 1832324 1832827 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1832324..1832827 Shigella flexneri 2a str. 2457T 1080505 NP_837406.1 CDS narU NC_004741.1 1833285 1834673 D residues 1 to 462 of 462 are 90.90 pct identical to residues 1 to 462 of 462 from Escherichia coli K-12 : B1469; nitrite extrusion protein 2 1833285..1834673 Shigella flexneri 2a str. 2457T 1078224 NP_837407.1 CDS S1896 NC_004741.1 1839823 1841043 D residues 1 to 406 of 406 are 98.02 pct identical to residues 1 to 406 of 406 from GenPept : >gb|AAK85176.1| (AF294823) transposase [Shigella sonnei]; partial; IS91 orf 1839823..1841043 Shigella flexneri 2a str. 2457T 1078226 NP_837408.1 CDS S1897 NC_004741.1 1841282 1842004 R residues 1 to 240 of 240 are 90.83 pct identical to residues 1 to 240 of 240 from Escherichia coli K-12 : B1450; DNA-binding transcriptional regulator complement(1841282..1842004) Shigella flexneri 2a str. 2457T 1078227 NP_837409.1 CDS yncB NC_004741.1 1842145 1843275 R residues 1 to 376 of 376 are 98.93 pct identical to residues 1 to 376 of 376 from Escherichia coli K-12 : B1449; oxidoreductase complement(1842145..1843275) Shigella flexneri 2a str. 2457T 1077096 NP_837410.2 CDS S1899 NC_004741.1 1843312 1844217 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(1843312..1844217) Shigella flexneri 2a str. 2457T 1078228 NP_837411.2 CDS S1900 NC_004741.1 1844175 1844540 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(1844175..1844540) Shigella flexneri 2a str. 2457T 1078230 NP_837412.1 CDS S1901 NC_004741.1 1844699 1845217 D residues 1 to 172 of 172 are 91.27 pct identical to residues 1 to 172 of 172 from Escherichia coli K-12 : B1448; resistance protein 1844699..1845217 Shigella flexneri 2a str. 2457T 1078232 NP_837413.1 CDS S1902 NC_004741.1 1845214 1845663 D residues 1 to 149 of 149 are 98.65 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B1447; hypothetical protein 1845214..1845663 Shigella flexneri 2a str. 2457T 1080576 NP_837414.1 CDS S1903 NC_004741.1 1845664 1845897 R residues 1 to 77 of 77 are 100.00 pct identical to residues 1 to 77 of 77 from Escherichia coli K-12 : B1446; hypothetical protein complement(1845664..1845897) Shigella flexneri 2a str. 2457T 1078233 NP_837415.1 CDS S1904 NC_004741.1 1845983 1846231 R residues 1 to 82 of 82 are 96.34 pct identical to residues 1 to 82 of 82 from Escherichia coli K-12 : B1445; hypothetical protein complement(1845983..1846231) Shigella flexneri 2a str. 2457T 1078235 NP_837416.1 CDS S1905 NC_004741.1 1847867 1849291 R catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase complement(1847867..1849291) Shigella flexneri 2a str. 2457T 1078236 NP_837417.1 CDS S1906 NC_004741.1 1849313 1850107 R residues 1 to 264 of 264 are 74.24 pct identical to residues 1 to 264 of 264 from Escherichia coli K-12 : B1443; transport system permease complement(1849313..1850107) Shigella flexneri 2a str. 2457T 1078239 NP_837418.1 CDS S1908 NC_004741.1 1850946 1851560 D residues 1 to 199 of 204 are 98.49 pct identical to residues 1 to 199 of 406 from GenPept : >gb|AAK85176.1| (AF294823) transposase [Shigella sonnei]; partial; IS1294 transposase 1850946..1851560 Shigella flexneri 2a str. 2457T 1078242 NP_837419.1 CDS S1909 NC_004741.1 1851560 1852006 D residues 1 to 148 of 148 are 83.33 pct identical to residues 19 to 168 of 168 from GenPept : >dbj|BAA84868.1| (AB024946) orf33 [Escherichia coli]; IS1294 transposase 1851560..1852006 Shigella flexneri 2a str. 2457T 1078676 NP_837420.1 CDS S1910 NC_004741.1 1852484 1852690 R residues 1 to 68 of 68 are 100.00 pct identical to residues 30 to 97 of 97 from GenPept : >gb|AAL72510.1| (AF386526) transposase tnpC-like protein [Shigella flexneri 2a]; partial; IS629 orfB complement(1852484..1852690) Shigella flexneri 2a str. 2457T 1078038 NP_837421.1 CDS S1911 NC_004741.1 1852746 1853105 R residues 1 to 119 of 119 are 100.00 pct identical to residues 17 to 135 of 135 from GenPept : >gb|AAL72509.1| (AF386526) transposase-like protein [Shigella flexneri 2a]; partial; IS629 orfB complement(1852746..1853105) Shigella flexneri 2a str. 2457T 1078245 NP_837422.1 CDS S1912 NC_004741.1 1853368 1853694 R residues 1 to 108 of 108 are 70.37 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72412.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA complement(1853368..1853694) Shigella flexneri 2a str. 2457T 1078246 NP_837423.1 CDS S1915 NC_004741.1 1856431 1856772 R residues 1 to 113 of 113 are 86.72 pct identical to residues 1 to 113 of 113 from Escherichia coli K-12 : B1839; hypothetical protein complement(1856431..1856772) Shigella flexneri 2a str. 2457T 1078247 NP_837424.1 CDS S1917 NC_004741.1 1857661 1858035 R residues 1 to 124 of 124 are 89.51 pct identical to residues 1 to 124 of 124 from Escherichia coli K-12 : B1841; hypothetical protein complement(1857661..1858035) Shigella flexneri 2a str. 2457T 1079924 NP_837425.1 CDS holE NC_004741.1 1858174 1858404 D residues 1 to 76 of 76 are 100.00 pct identical to residues 1 to 76 of 76 from Escherichia coli K-12 : B1842; DNA polymerase III subunit theta 1858174..1858404 Shigella flexneri 2a str. 2457T 1078156 NP_837426.1 CDS S1919 NC_004741.1 1858737 1859162 D residues 1 to 141 of 141 are 99.29 pct identical to residues 78 to 218 of 218 from Escherichia coli K-12 : B1843; hypothetical protein 1858737..1859162 Shigella flexneri 2a str. 2457T 1078252 NP_837427.1 CDS S1920 NC_004741.1 1859186 1859848 D 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1859186..1859848 Shigella flexneri 2a str. 2457T 1078253 NP_837428.1 CDS ptrB NC_004741.1 1859845 1861905 R PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 complement(1859845..1861905) Shigella flexneri 2a str. 2457T 1078255 NP_837429.1 CDS yebE NC_004741.1 1862115 1862774 R residues 1 to 219 of 219 are 72.60 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B1846; hypothetical protein complement(1862115..1862774) Shigella flexneri 2a str. 2457T 1076941 NP_837430.1 CDS yebF NC_004741.1 1863101 1863457 R secreted protein; unknown function; hypothetical protein complement(1863101..1863457) Shigella flexneri 2a str. 2457T 1078256 NP_837431.1 CDS purT NC_004741.1 1863948 1865126 D non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 1863948..1865126 Shigella flexneri 2a str. 2457T 1078096 NP_837432.1 CDS eda NC_004741.1 1865182 1865823 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(1865182..1865823) Shigella flexneri 2a str. 2457T 1078259 NP_837433.1 CDS edd NC_004741.1 1865860 1867671 R catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase complement(1865860..1867671) Shigella flexneri 2a str. 2457T 1078258 NP_837434.1 CDS zwf NC_004741.1 1867906 1869381 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(1867906..1869381) Shigella flexneri 2a str. 2457T 1078260 NP_837435.1 CDS yebK NC_004741.1 1869719 1870540 D Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 1869719..1870540 Shigella flexneri 2a str. 2457T 1080143 NP_837436.1 CDS pykA NC_004741.1 1870718 1872160 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1870718..1872160 Shigella flexneri 2a str. 2457T 1078261 NP_837437.1 CDS msbB NC_004741.1 1872291 1873262 R Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase complement(1872291..1873262) Shigella flexneri 2a str. 2457T 1078262 NP_837438.1 CDS yebA NC_004741.1 1873382 1874704 R residues 22 to 440 of 440 are 100.00 pct identical to residues 1 to 419 of 419 from Escherichia coli K-12 : B1856; hypothetical protein complement(1873382..1874704) Shigella flexneri 2a str. 2457T 1079644 NP_837439.2 CDS znuA NC_004741.1 1874720 1875652 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component complement(1874720..1875652) Shigella flexneri 2a str. 2457T 1078264 NP_837440.1 CDS znuC NC_004741.1 1875731 1876486 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 1875731..1876486 Shigella flexneri 2a str. 2457T 1078265 NP_837441.1 CDS znuB NC_004741.1 1876483 1877268 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component 1876483..1877268 Shigella flexneri 2a str. 2457T 1078266 NP_837442.1 CDS ruvB NC_004741.1 1877415 1878425 R promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(1877415..1878425) Shigella flexneri 2a str. 2457T 1078268 NP_837443.1 CDS ruvA NC_004741.1 1878434 1879045 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(1878434..1879045) Shigella flexneri 2a str. 2457T 1077912 NP_837444.1 CDS ruvC NC_004741.1 1879923 1880444 R endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(1879923..1880444) Shigella flexneri 2a str. 2457T 1078270 NP_837445.1 CDS yebC NC_004741.1 1880479 1881219 R residues 1 to 246 of 246 are 100.00 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B1864; hypothetical protein complement(1880479..1881219) Shigella flexneri 2a str. 2457T 1078271 NP_837446.1 CDS ntpA NC_004741.1 1881248 1881730 R converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase complement(1881248..1881730) Shigella flexneri 2a str. 2457T 1078272 NP_837447.1 CDS aspS NC_004741.1 1881818 1883590 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(1881818..1883590) Shigella flexneri 2a str. 2457T 1078274 NP_837448.1 CDS S1944 NC_004741.1 1884346 1885542 D residues 1 to 398 of 398 are 91.45 pct identical to residues 1 to 398 of 398 from GenPept : >gb|AAL72391.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl4 orf 1884346..1885542 Shigella flexneri 2a str. 2457T 1078276 NP_837449.1 CDS S1946 NC_004741.1 1886271 1886519 D residues 1 to 82 of 82 are 96.34 pct identical to residues 1 to 82 of 82 from GenPept : >gb|AAG57731.1|AE005491_11 (AE005491) Z3916 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 1886271..1886519 Shigella flexneri 2a str. 2457T 1078278 NP_837450.1 CDS ipaH_4 NC_004741.1 1887119 1888870 D residues 1 to 583 of 583 are 99.82 pct identical to residues 1 to 583 of 583 from NRprotein_Feb03 : >ref|NP_707728.1| IpaH9.8 [Shigella flexneri 2a str. 301] gb|AAN43435.1|AE015207_3 IpaH9.8 [Shigella flexneri 2a str. 301]; invasion plasmid antigen 1887119..1888870 Shigella flexneri 2a str. 2457T 1078279 NP_837451.1 CDS S1948 NC_004741.1 1888871 1889050 R no significant similarities; hypothetical protein complement(1888871..1889050) Shigella flexneri 2a str. 2457T 1080555 NP_837452.1 CDS S1949 NC_004741.1 1889050 1889673 R residues 21 to 207 of 207 are 68.44 pct identical to residues 2 to 188 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein complement(1889050..1889673) Shigella flexneri 2a str. 2457T 1078280 NP_837453.1 CDS S1950 NC_004741.1 1891397 1891939 D residues 1 to 180 of 180 are 70.55 pct identical to residues 1 to 179 of 179 from GenPept : >emb|CAA80648.1| (Z23101) Sequence similarity to P4 ORF199 suggests ORF179 expression [Shigella flexneri]; hypothetical protein 1891397..1891939 Shigella flexneri 2a str. 2457T 1078281 NP_837454.1 CDS S1952 NC_004741.1 1892281 1892691 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1892281..1892691 Shigella flexneri 2a str. 2457T 1078282 NP_837455.2 CDS S1953 NC_004741.1 1892649 1893554 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1892649..1893554 Shigella flexneri 2a str. 2457T 1078283 NP_837456.1 CDS S1954 NC_004741.1 1894097 1894372 D Rac prophage hypothetical protein; hypothetical protein 1894097..1894372 Shigella flexneri 2a str. 2457T 1079737 NP_837457.1 CDS S1955 NC_004741.1 1894472 1895896 D residues 1 to 474 of 474 are 96.20 pct identical to residues 1 to 474 of 1042 from GenPept : >emb|CAD05617.1| (AL627272) exodeoxyribonuclease VIII [Salmonella enterica subsp. enterica serovar Typhi]; exodeoxyribonuclease VIII 1894472..1895896 Shigella flexneri 2a str. 2457T 1078284 NP_837458.1 CDS S1957 NC_004741.1 1897139 1897459 D residues 10 to 105 of 106 are 83.33 pct identical to residues 2 to 97 of 98 from GenPept : >dbj|BAB87956.1| (AP004402) Gam protein [Stx2 converting bacteriophage I]; host-nuclease inhibitor protein Gam 1897139..1897459 Shigella flexneri 2a str. 2457T 1078287 NP_837459.1 CDS S1958 NC_004741.1 1897519 1898562 D residues 1 to 181 of 347 are 28.27 pct identical to residues 15 to 188 of 340 from GenPept : >gb|AAK94416.1|AF396866_81 (AF396866) p81 [Bacteriophage Mx8]; bacteriophage protein 1897519..1898562 Shigella flexneri 2a str. 2457T 1078288 NP_837460.1 CDS S1959 NC_004741.1 1898637 1898963 D residues 1 to 108 of 108 are 74.07 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAF09023.1| (AF139596) unknown [Shigella flexneri]; IS629 orfA 1898637..1898963 Shigella flexneri 2a str. 2457T 1078290 NP_837461.1 CDS S1960 NC_004741.1 1899199 1899846 D residues 1 to 215 of 215 are 99.06 pct identical to residues 8 to 222 of 222 from GenPept : >gb|AAL72361.1| (AF386526) transposase [Shigella flexneri 2a]; partial; IS629 orfB 1899199..1899846 Shigella flexneri 2a str. 2457T 1078291 NP_837462.1 CDS S1961 NC_004741.1 1900250 1900753 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(1900250..1900753) Shigella flexneri 2a str. 2457T 1078292 NP_837463.1 CDS S1962 NC_004741.1 1900672 1900947 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1900672..1900947) Shigella flexneri 2a str. 2457T 1078293 NP_837464.1 CDS S1963 NC_004741.1 1901037 1901642 D residues 1 to 201 of 201 are 97.51 pct identical to residues 211 to 411 of 411 from GenPept : >gb|AAG56452.1|AE005371_8 (AE005371) integrase for prophage CP-933R [Escherichia coli O157:H7 EDL933]; integrase for prophage CP-933R 1901037..1901642 Shigella flexneri 2a str. 2457T 1078294 NP_837465.1 CDS sitA NC_004741.1 1902098 1902988 D residues 16 to 296 of 296 are 79.35 pct identical to residues 24 to 304 of 305 from GenPept : >gb|AAL21741.1| (AE008830) Salmonella iron transporter: fur regulated [Salmonella typhimurium LT2]; Iron transport protein 1902098..1902988 Shigella flexneri 2a str. 2457T 1078295 NP_837466.1 CDS sitB NC_004741.1 1902988 1903815 D residues 2 to 266 of 275 are 77.73 pct identical to residues 1 to 265 of 273 from GenPept : >emb|CAD05969.1| (AL627276) Iron transport protein, ATP-binding component [Salmonella enterica subsp. enterica serovar Typhi]; Iron transport protein, ATP-binding component 1902988..1903815 Shigella flexneri 2a str. 2457T 1078296 NP_837467.1 CDS sitC NC_004741.1 1903812 1904669 D residues 1 to 277 of 285 are 75.45 pct identical to residues 1 to 277 of 286 from GenPept : >gb|AAL21743.1| (AE008830) Salmonella iron transporter: fur regulated [Salmonella typhimurium LT2]; Iron transport protein 1903812..1904669 Shigella flexneri 2a str. 2457T 1078297 NP_837468.1 CDS sitD NC_004741.1 1904666 1905523 D residues 2 to 263 of 285 are 64.50 pct identical to residues 3 to 264 of 282 from GenPept : >emb|CAD05971.1| (AL627276) Iron transport protein, inner membrane component [Salmonella enterica subsp. enterica serovar Typhi]; Iron transport protein, inner membrane component 1904666..1905523 Shigella flexneri 2a str. 2457T 1078298 NP_837469.1 CDS S1968 NC_004741.1 1905724 1906287 R residues 1 to 187 of 187 are 70.05 pct identical to residues 2 to 188 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein complement(1905724..1906287) Shigella flexneri 2a str. 2457T 1078299 NP_837470.1 CDS S1969 NC_004741.1 1906298 1907566 R residues 1 to 420 of 422 are 37.55 pct identical to residues 1 to 488 of 490 from GenPept : >emb|CAC83574.1| (AJ298298) tail fiber protein [Bacteriophage P27]; tail fiber protein complement(1906298..1907566) Shigella flexneri 2a str. 2457T 1078300 NP_837471.1 CDS S1970 NC_004741.1 1907590 1908078 R residues 9 to 162 of 162 are 75.97 pct identical to residues 29 to 182 of 182 from GenPept : >emb|CAC83573.1| (AJ298298) tail fiber assembly protein [Bacteriophage P27]; tail fiber assembly protein complement(1907590..1908078) Shigella flexneri 2a str. 2457T 1078301 NP_837472.1 CDS S1971 NC_004741.1 1908138 1908341 R residues 5 to 67 of 67 are 58.73 pct identical to residues 497 to 558 of 558 from GenPept : >dbj|BAA00552.1| (D00660) Bcv gene product [Shigella boydii]; hypothetical protein complement(1908138..1908341) Shigella flexneri 2a str. 2457T 1078302 NP_837473.1 CDS S1972 NC_004741.1 1908558 1909271 R residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB complement(1908558..1909271) Shigella flexneri 2a str. 2457T 1078303 NP_837474.1 CDS S1973 NC_004741.1 1909479 1909688 R residues 1 to 69 of 69 are 100.00 pct identical to residues 99 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS1 orfB complement(1909479..1909688) Shigella flexneri 2a str. 2457T 1080732 NP_837475.1 CDS S1975 NC_004741.1 1909901 1910176 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(1909901..1910176) Shigella flexneri 2a str. 2457T 1078304 NP_837476.1 CDS S1978 NC_004741.1 1910765 1911391 R residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB complement(1910765..1911391) Shigella flexneri 2a str. 2457T 1078305 NP_837477.1 CDS S1980 NC_004741.1 1911631 1911933 R residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA complement(1911631..1911933) Shigella flexneri 2a str. 2457T 1078307 NP_837478.1 CDS S1981 NC_004741.1 1912634 1914238 R residues 15 to 534 of 534 are 74.24 pct identical to residues 7 to 531 of 548 from GenPept : >emb|CAD02867.1| (AL627277) possible integrase [Salmonella enterica subsp. enterica serovar Typhi]; integrase complement(1912634..1914238) Shigella flexneri 2a str. 2457T 1078308 NP_837479.1 CDS S1986 NC_004741.1 1914839 1915528 R residues 1 to 229 of 229 are 91.70 pct identical to residues 1 to 229 of 229 from GenPept : >gb|AAK16973.1|AE006460_11 (AE006460) Q antiterminator encoded by prophage CP-933P [Escherichia coli O157:H7 EDL933]; Q antiterminator encoded by prophage CP-933P complement(1914839..1915528) Shigella flexneri 2a str. 2457T 1078313 NP_837480.1 CDS S1987 NC_004741.1 1915525 1915884 R residues 1 to 119 of 119 are 92.43 pct identical to residues 1 to 119 of 119 from GenPept : >gb|AAK16974.1|AE006460_12 (AE006460) endonuclease encoded by cryptic prophage CP-933P [Escherichia coli O157:H7 EDL933]; crossover junction endodeoxyribonuclease complement(1915525..1915884) Shigella flexneri 2a str. 2457T 1078314 NP_837481.1 CDS S1989 NC_004741.1 1916531 1917244 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 1916531..1917244 Shigella flexneri 2a str. 2457T 1078315 NP_837482.1 CDS S1990 NC_004741.1 1917742 1918569 D residues 1 to 275 of 275 are 89.81 pct identical to residues 1 to 275 of 275 from GenPept : >emb|CAC83523.1| (AJ298298) serine protease [Bacteriophage P27]; serine protease 1917742..1918569 Shigella flexneri 2a str. 2457T 1078187 NP_837483.1 CDS S1991 NC_004741.1 1918613 1919362 D residues 114 to 246 of 249 are 69.92 pct identical to residues 102 to 234 of 235 from GenPept : >emb|CAC83532.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein 1918613..1919362 Shigella flexneri 2a str. 2457T 1078316 NP_837484.1 CDS S1992 NC_004741.1 1919359 1919928 D no significant similarities; hypothetical protein 1919359..1919928 Shigella flexneri 2a str. 2457T 1078317 NP_837485.1 CDS S1994 NC_004741.1 1920052 1920294 D residues 1 to 80 of 80 are 85.00 pct identical to residues 1 to 80 of 80 from GenPept : >dbj|BAB36434.1| (AP002560) hypothetical protein [Escherichia coli O157:H7]; hypothetical protein 1920052..1920294 Shigella flexneri 2a str. 2457T 1078318 NP_837486.1 CDS S1995 NC_004741.1 1920298 1920444 D residues 1 to 44 of 48 are 77.27 pct identical to residues 1 to 44 of 44 from GenPept : >gb|AAG57257.1|AE005444_7 (AE005444) unknown protein encoded within prophage CP-933V [Escherichia coli O157:H7 EDL933]; bacteriophage protein 1920298..1920444 Shigella flexneri 2a str. 2457T 1078254 NP_837487.1 CDS S1998 NC_004741.1 1921491 1921793 R residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA complement(1921491..1921793) Shigella flexneri 2a str. 2457T 1078319 NP_837488.1 CDS yecN NC_004741.1 1922426 1922821 D residues 15 to 131 of 131 are 99.14 pct identical to residues 25 to 141 of 141 from Escherichia coli K-12 : B1869; hypothetical protein 1922426..1922821 Shigella flexneri 2a str. 2457T 1079302 NP_837489.1 CDS yecO NC_004741.1 1922862 1923605 D residues 1 to 247 of 247 are 99.59 pct identical to residues 1 to 247 of 247 from Escherichia coli K-12 : B1870; hypothetical protein 1922862..1923605 Shigella flexneri 2a str. 2457T 1078321 NP_837490.1 CDS yecP NC_004741.1 1923602 1924573 D residues 1 to 323 of 323 are 98.14 pct identical to residues 1 to 323 of 323 from Escherichia coli K-12 : B1871; enzyme 1923602..1924573 Shigella flexneri 2a str. 2457T 1078322 NP_837491.1 CDS bisZ NC_004741.1 1924738 1927167 R residues 1 to 809 of 809 are 96.04 pct identical to residues 7 to 815 of 815 from Escherichia coli K-12 : B1872; biotin sulfoxide reductase complement(1924738..1927167) Shigella flexneri 2a str. 2457T 1078324 NP_837492.1 CDS yecK NC_004741.1 1927192 1928292 R residues 1 to 366 of 366 are 92.07 pct identical to residues 1 to 366 of 366 from Escherichia coli K-12 : B1873; cytochrome C-type protein complement(1927192..1928292) Shigella flexneri 2a str. 2457T 1078325 NP_837493.1 CDS cutC NC_004741.1 1928680 1929120 R residues 1 to 146 of 146 are 100.00 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 : B1874; copper homeostasis protein complement(1928680..1929120) Shigella flexneri 2a str. 2457T 1078326 NP_837494.1 CDS yecM NC_004741.1 1929440 1930006 R residues 1 to 188 of 188 are 97.34 pct identical to residues 3 to 190 of 190 from Escherichia coli K-12 : B1875; hypothetical protein complement(1929440..1930006) Shigella flexneri 2a str. 2457T 1078327 NP_837495.1 CDS argS NC_004741.1 1930222 1931955 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1930222..1931955 Shigella flexneri 2a str. 2457T 1078328 NP_837496.1 CDS S2009 NC_004741.1 1932840 1933274 R residues 16 to 144 of 144 are 99.22 pct identical to residues 94 to 222 of 222 from GenPept : >gb|AAL72362.1| (AF386526) transposase [Shigella flexneri 2a]; partial; IS629 orfB complement(1932840..1933274) Shigella flexneri 2a str. 2457T 1078330 NP_837497.1 CDS S2011 NC_004741.1 1933709 1934035 R residues 1 to 108 of 108 are 80.55 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72409.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA complement(1933709..1934035) Shigella flexneri 2a str. 2457T 1078331 NP_837498.1 CDS flhE NC_004741.1 1934087 1934425 R residues 1 to 112 of 112 are 98.21 pct identical to residues 1 to 112 of 130 from Escherichia coli K-12 : B1878; flagellar protein complement(1934087..1934425) Shigella flexneri 2a str. 2457T 1078332 NP_837499.1 CDS flhB NC_004741.1 1936449 1937642 R membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB complement(1936449..1937642) Shigella flexneri 2a str. 2457T 1078334 NP_837500.1 CDS S2015 NC_004741.1 1937878 1938336 D residues 1 to 128 of 152 are 40.90 pct identical to residues 1 to 122 of 465 from GenPept : >emb|CAD00870.1| (AL591984) similar to dGTP triphosphohydrolase [Listeria monocytogenes]; hypothetical protein 1937878..1938336 Shigella flexneri 2a str. 2457T 1078335 NP_837501.1 CDS S2018 NC_004741.1 1939126 1939428 R residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA complement(1939126..1939428) Shigella flexneri 2a str. 2457T 1078336 NP_837502.1 CDS S2019 NC_004741.1 1939569 1939964 D hypothetical protein 1939569..1939964 Shigella flexneri 2a str. 2457T 1078337 NP_837503.1 CDS S2020 NC_004741.1 1940459 1941172 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 1940459..1941172 Shigella flexneri 2a str. 2457T 1078339 NP_837504.1 CDS cheZ NC_004741.1 1941677 1942321 R cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ complement(1941677..1942321) Shigella flexneri 2a str. 2457T 1078341 NP_837505.1 CDS cheY NC_004741.1 1942332 1942721 R chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY complement(1942332..1942721) Shigella flexneri 2a str. 2457T 1078342 NP_837506.1 CDS cheB NC_004741.1 1942736 1943785 R regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase complement(1942736..1943785) Shigella flexneri 2a str. 2457T 1078343 NP_837507.1 CDS cheR NC_004741.1 1943788 1944648 R methylates the MCP; chemotaxis methyltransferase CheR complement(1943788..1944648) Shigella flexneri 2a str. 2457T 1078344 NP_837508.1 CDS tap NC_004741.1 1944667 1946268 R mediates taxis toward dipeptides; methyl-accepting protein IV complement(1944667..1946268) Shigella flexneri 2a str. 2457T 1078345 NP_837509.1 CDS tar NC_004741.1 1946314 1947975 R residues 1 to 553 of 553 are 83.18 pct identical to residues 1 to 553 of 553 from Escherichia coli K-12 : B1886; methyl-accepting chemotaxis protein II, aspartate sensor receptor complement(1946314..1947975) Shigella flexneri 2a str. 2457T 1078346 NP_837510.1 CDS cheW NC_004741.1 1948120 1948623 R residues 1 to 167 of 167 are 91.01 pct identical to residues 1 to 167 of 167 from Escherichia coli K-12 : B1887; purine-binding chemotaxis protein complement(1948120..1948623) Shigella flexneri 2a str. 2457T 1078347 NP_837511.1 CDS cheA NC_004741.1 1948644 1950608 R chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA complement(1948644..1950608) Shigella flexneri 2a str. 2457T 1078348 NP_837512.1 CDS motB NC_004741.1 1950613 1951539 R with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB complement(1950613..1951539) Shigella flexneri 2a str. 2457T 1078576 NP_837513.1 CDS motA NC_004741.1 1951536 1952423 R With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA complement(1951536..1952423) Shigella flexneri 2a str. 2457T 1078349 NP_837514.1 CDS flhC NC_004741.1 1952550 1953128 R With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC complement(1952550..1953128) Shigella flexneri 2a str. 2457T 1078350 NP_837515.1 CDS S2033 NC_004741.1 1953391 1953666 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1953391..1953666 Shigella flexneri 2a str. 2457T 1078352 NP_837516.1 CDS S2034 NC_004741.1 1953585 1954088 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1953585..1954088 Shigella flexneri 2a str. 2457T 1078353 NP_837517.1 CDS otsB NC_004741.1 1954526 1955326 R biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase complement(1954526..1955326) Shigella flexneri 2a str. 2457T 1078355 NP_837518.1 CDS araH NC_004741.1 1955493 1956482 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease complement(1955493..1956482) Shigella flexneri 2a str. 2457T 1078356 NP_837519.1 CDS araG NC_004741.1 1956494 1958008 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein complement(1956494..1958008) Shigella flexneri 2a str. 2457T 1078357 NP_837520.1 CDS yecI NC_004741.1 1959864 1960367 D residues 1 to 167 of 167 are 100.00 pct identical to residues 1 to 167 of 167 from Escherichia coli K-12 : B1902; ferritin-like protein 1959864..1960367 Shigella flexneri 2a str. 2457T 1078359 NP_837522.1 CDS S2043 NC_004741.1 1961162 1961485 D residues 1 to 107 of 107 are 88.78 pct identical to residues 1 to 107 of 107 from Escherichia coli K-12 : B1904; hypothetical protein 1961162..1961485 Shigella flexneri 2a str. 2457T 1078361 NP_837523.1 CDS ftn NC_004741.1 1961656 1962153 D cytoplasmic iron storage protein; ferritin 1961656..1962153 Shigella flexneri 2a str. 2457T 1078362 NP_837524.1 CDS yecH NC_004741.1 1962190 1962429 R residues 1 to 79 of 79 are 96.20 pct identical to residues 1 to 79 of 79 from Escherichia coli K-12 : B1906; hypothetical protein complement(1962190..1962429) Shigella flexneri 2a str. 2457T 1078363 NP_837525.1 CDS tyrP NC_004741.1 1962619 1963830 D residues 1 to 403 of 403 are 83.62 pct identical to residues 1 to 403 of 403 from Escherichia coli K-12 : B1907; tyrosine-specific transport protein 1962619..1963830 Shigella flexneri 2a str. 2457T 1078364 NP_837526.1 CDS yecA NC_004741.1 1963892 1964557 R residues 1 to 221 of 221 are 100.00 pct identical to residues 1 to 221 of 221 from Escherichia coli K-12 : B1908; hypothetical protein complement(1963892..1964557) Shigella flexneri 2a str. 2457T 1078365 NP_837527.1 CDS pgsA NC_004741.1 1965207 1965755 R residues 1 to 182 of 182 are 99.45 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 : B1912; phosphatidylglycerophosphate synthetase complement(1965207..1965755) Shigella flexneri 2a str. 2457T 1078369 NP_837528.2 CDS uvrC NC_004741.1 1965812 1967644 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C complement(1965812..1967644) Shigella flexneri 2a str. 2457T 1078370 NP_837529.1 CDS uvrY NC_004741.1 1967641 1968297 R in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator complement(1967641..1968297) Shigella flexneri 2a str. 2457T 1078371 NP_837530.1 CDS yecF NC_004741.1 1968756 1968980 D residues 1 to 74 of 74 are 100.00 pct identical to residues 1 to 74 of 74 from Escherichia coli K-12 : B1915; hypothetical protein 1968756..1968980 Shigella flexneri 2a str. 2457T 1078372 NP_837531.1 CDS sdiA NC_004741.1 1969007 1969633 R residues 1 to 207 of 208 are 96.13 pct identical to residues 1 to 207 of 240 from Escherichia coli K-12 : B1916; transcriptional regulator of ftsQAZ gene cluster complement(1969007..1969633) Shigella flexneri 2a str. 2457T 1078373 NP_837532.1 CDS yecC NC_004741.1 1969863 1970615 R residues 1 to 250 of 250 are 89.60 pct identical to residues 1 to 250 of 250 from Escherichia coli K-12 : B1917; amino-acid ABC transporter ATP-binding protein YecC complement(1969863..1970615) Shigella flexneri 2a str. 2457T 1078405 NP_837533.1 CDS yecS NC_004741.1 1970612 1971280 R residues 1 to 222 of 222 are 85.58 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 : B1918; transport system permease (former yecC) complement(1970612..1971280) Shigella flexneri 2a str. 2457T 1078374 NP_837534.2 CDS yedO NC_004741.1 1971295 1972281 R catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase complement(1971295..1972281) Shigella flexneri 2a str. 2457T 1078375 NP_837535.1 CDS fliZ NC_004741.1 1973275 1973862 R expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ complement(1973275..1973862) Shigella flexneri 2a str. 2457T 1078376 NP_837536.1 CDS fliC NC_004741.1 1974756 1976408 R structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin complement(1974756..1976408) Shigella flexneri 2a str. 2457T 1078378 NP_837537.1 CDS fliD NC_004741.1 1976674 1978080 D involved in flagellin assembly; flagellar capping protein 1976674..1978080 Shigella flexneri 2a str. 2457T 1078379 NP_837538.1 CDS fliS NC_004741.1 1978105 1978515 D flagellin specific chaperone; flagellar protein FliS 1978105..1978515 Shigella flexneri 2a str. 2457T 1078392 NP_837539.1 CDS fliT NC_004741.1 1978515 1978880 D binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 1978515..1978880 Shigella flexneri 2a str. 2457T 1078380 NP_837540.1 CDS amyA NC_004741.1 1978958 1980445 D converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 1978958..1980445 Shigella flexneri 2a str. 2457T 1077340 NP_837541.1 CDS yedD NC_004741.1 1980479 1980892 R residues 16 to 137 of 137 are 99.18 pct identical to residues 16 to 137 of 137 from Escherichia coli K-12 : B1928; hypothetical protein complement(1980479..1980892) Shigella flexneri 2a str. 2457T 1078381 NP_837542.1 CDS yedE NC_004741.1 1981079 1982284 D residues 1 to 401 of 401 are 86.78 pct identical to residues 1 to 401 of 401 from Escherichia coli K-12 : B1929; inner membrane protein 1981079..1982284 Shigella flexneri 2a str. 2457T 1076455 NP_837543.1 CDS yedF NC_004741.1 1982281 1982514 D residues 1 to 77 of 77 are 100.00 pct identical to residues 1 to 77 of 77 from Escherichia coli K-12 : B1930; hypothetical protein 1982281..1982514 Shigella flexneri 2a str. 2457T 1078382 NP_837544.1 CDS S2072 NC_004741.1 1983331 1984137 R residues 1 to 268 of 268 are 97.76 pct identical to residues 135 to 402 of 402 from GenPept : >gb|AAG57523.1|AE005470_10 (AE005470) virulence protein [Escherichia coli O157:H7 EDL933]; virulence protein complement(1983331..1984137) Shigella flexneri 2a str. 2457T 1078383 NP_837545.1 CDS nmpC NC_004741.1 1985546 1986628 D residues 1 to 360 of 360 are 84.65 pct identical to residues 1 to 365 of 365 from GenPept : >gb|AAA32301.1| (J02580) outer membrane porin protein [Bacteriophage PA-2]; outer membrane porin protein C precurser 1985546..1986628 Shigella flexneri 2a str. 2457T 1078384 NP_837546.1 CDS S4819 NC_004741.1 1987178 1987915 R residues 1 to 245 of 245 are 100.00 pct identical to residues 1 to 245 of 245 from NRprotein_Feb03 : >ref|NP_707820.1| ARAC-type regulatory protein [Shigella flexneri 2a str. 301] gb|AAN43527.1|AE015216_2 ARAC-type regulatory protein [Shigella flexneri 2a str. 301]; regulator complement(1987178..1987915) Shigella flexneri 2a str. 2457T 1076461 NP_837547.1 CDS ybcL NC_004741.1 1987925 1988476 R DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown; kinase inhibitor complement(1987925..1988476) Shigella flexneri 2a str. 2457T 1078386 NP_837548.1 CDS emrE NC_004741.1 1988645 1988977 R member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein complement(1988645..1988977) Shigella flexneri 2a str. 2457T 1078419 NP_837549.1 CDS fliE NC_004741.1 1989322 1989636 R forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE complement(1989322..1989636) Shigella flexneri 2a str. 2457T 1078390 NP_837550.1 CDS fliG NC_004741.1 1991502 1992497 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 1991502..1992497 Shigella flexneri 2a str. 2457T 1078393 NP_837551.1 CDS fliH NC_004741.1 1992490 1993176 D binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 1992490..1993176 Shigella flexneri 2a str. 2457T 1079810 NP_837552.1 CDS fliI NC_004741.1 1993176 1994549 D involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 1993176..1994549 Shigella flexneri 2a str. 2457T 1078394 NP_837553.1 CDS fliK NC_004741.1 1994909 1996036 D residues 1 to 375 of 375 are 93.86 pct identical to residues 1 to 375 of 375 from Escherichia coli K-12 : B1943; flagellar hook-length control protein 1994909..1996036 Shigella flexneri 2a str. 2457T 1079013 NP_837554.1 CDS fliL NC_004741.1 1996141 1996605 D interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 1996141..1996605 Shigella flexneri 2a str. 2457T 1078398 NP_837555.1 CDS fliM NC_004741.1 1996610 1997614 D with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 1996610..1997614 Shigella flexneri 2a str. 2457T 1076460 NP_837556.1 CDS fliN NC_004741.1 1997611 1998024 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 1997611..1998024 Shigella flexneri 2a str. 2457T 1078399 NP_837557.2 CDS fliO NC_004741.1 1998027 1998392 D with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 1998027..1998392 Shigella flexneri 2a str. 2457T 1078400 NP_837558.1 CDS fliQ NC_004741.1 1999167 1999436 D with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 1999167..1999436 Shigella flexneri 2a str. 2457T 1078402 NP_837559.1 CDS fliR NC_004741.1 1999445 2000230 D FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 1999445..2000230 Shigella flexneri 2a str. 2457T 1078403 NP_837560.1 CDS rcsA NC_004741.1 2000515 2001138 D residues 1 to 207 of 207 are 99.51 pct identical to residues 1 to 207 of 207 from Escherichia coli K-12 : B1951; positive regulator for ctr capsule biosynthesis, positive transcription factor 2000515..2001138 Shigella flexneri 2a str. 2457T 1076708 NP_837561.1 CDS dsrB NC_004741.1 2001182 2001370 R residues 1 to 62 of 62 are 98.38 pct identical to residues 1 to 62 of 62 from Escherichia coli K-12 : B1952; hypothetical protein complement(2001182..2001370) Shigella flexneri 2a str. 2457T 1078404 NP_837562.1 CDS S2092 NC_004741.1 2001533 2001760 D residues 1 to 75 of 75 are 98.66 pct identical to residues 6 to 80 of 80 from Escherichia coli K-12 : B1953; hypothetical protein 2001533..2001760 Shigella flexneri 2a str. 2457T 1078406 NP_837563.1 CDS S2096 NC_004741.1 2004735 2004917 R residues 1 to 60 of 60 are 98.33 pct identical to residues 1 to 60 of 60 from Escherichia coli K-12 : B1957; hypothetical protein complement(2004735..2004917) Shigella flexneri 2a str. 2457T 1078413 NP_837564.1 CDS yedI NC_004741.1 2004996 2005913 R residues 23 to 305 of 305 are 87.98 pct identical to residues 23 to 305 of 305 from Escherichia coli K-12 : B1958; hypothetical protein complement(2004996..2005913) Shigella flexneri 2a str. 2457T 1079036 NP_837565.1 CDS yedA NC_004741.1 2006086 2007006 D residues 1 to 306 of 306 are 83.33 pct identical to residues 1 to 306 of 306 from Escherichia coli K-12 : B1959; hypothetical protein 2006086..2007006 Shigella flexneri 2a str. 2457T 1078414 NP_837566.1 CDS vsr NC_004741.1 2006995 2007465 R residues 1 to 156 of 156 are 98.07 pct identical to residues 1 to 156 of 156 from Escherichia coli K-12 : B1960; DNA mismatch endonuclease, patch repair protein complement(2006995..2007465) Shigella flexneri 2a str. 2457T 1078415 NP_837567.1 CDS dcm NC_004741.1 2007446 2008864 R residues 1 to 472 of 472 are 99.15 pct identical to residues 1 to 472 of 472 from Escherichia coli K-12 : B1961; DNA cytosine methylase complement(2007446..2008864) Shigella flexneri 2a str. 2457T 1080935 NP_837568.1 CDS S2103 NC_004741.1 2009769 2010581 R residues 1 to 270 of 270 are 95.55 pct identical to residues 10 to 279 of 279 from GenPept : >gb|AAG53988.1|AF327445_2 (AF327445) transposase B [Pantoea agglomerans]; ISEhe3 orfB complement(2009769..2010581) Shigella flexneri 2a str. 2457T 1078418 NP_837569.1 CDS S2104 NC_004741.1 2010638 2010916 R residues 1 to 92 of 92 are 92.39 pct identical to residues 3 to 94 of 94 from GenPept : >gb|AAG53987.1|AF327445_1 (AF327445) transposase A [Pantoea agglomerans]; ISEhe3 orfA complement(2010638..2010916) Shigella flexneri 2a str. 2457T 1078417 NP_837570.1 CDS S2105 NC_004741.1 2010943 2011830 D residues 31 to 267 of 295 are 59.18 pct identical to residues 53 to 296 of 351 from GenPept : >emb|CAA23605.1| (V00316) phoE protein [Escherichia coli]; outer membrane pore protein 2010943..2011830 Shigella flexneri 2a str. 2457T 1078420 NP_837571.2 CDS S2106 NC_004741.1 2011755 2012660 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(2011755..2012660) Shigella flexneri 2a str. 2457T 1078421 NP_837572.2 CDS S2107 NC_004741.1 2012618 2012983 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(2012618..2012983) Shigella flexneri 2a str. 2457T 1078422 NP_837573.1 CDS S2108 NC_004741.1 2013047 2013256 D residues 2 to 69 of 69 are 61.76 pct identical to residues 298 to 359 of 359 from GenPept : >emb|CAA09665.1| (AJ011501) OmpK35 porin [Klebsiella pneumoniae]; outer membrane protein 2013047..2013256 Shigella flexneri 2a str. 2457T 1078423 NP_837574.1 CDS S2109 NC_004741.1 2013884 2014159 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2013884..2014159 Shigella flexneri 2a str. 2457T 1078424 NP_837575.1 CDS S2110 NC_004741.1 2014078 2014581 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2014078..2014581 Shigella flexneri 2a str. 2457T 1078433 NP_837576.1 CDS yedU NC_004741.1 2014627 2015499 D Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2014627..2015499 Shigella flexneri 2a str. 2457T 1078425 NP_837577.1 CDS yedV NC_004741.1 2015585 2016943 R residues 1 to 452 of 452 are 93.14 pct identical to residues 1 to 452 of 452 from Escherichia coli K-12 : B1968; 2-component sensor protein complement(2015585..2016943) Shigella flexneri 2a str. 2457T 1078407 NP_837578.1 CDS yedW NC_004741.1 2016943 2017614 R induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW complement(2016943..2017614) Shigella flexneri 2a str. 2457T 1078427 NP_837579.1 CDS S2114 NC_004741.1 2017747 2018160 D residues 1 to 137 of 137 are 99.27 pct identical to residues 1 to 137 of 137 from Escherichia coli K-12 : B1970; hypothetical protein 2017747..2018160 Shigella flexneri 2a str. 2457T 1076469 NP_837580.1 CDS S2116 NC_004741.1 2019274 2019909 D in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2019274..2019909 Shigella flexneri 2a str. 2457T 1078429 NP_837581.1 CDS S2117 NC_004741.1 2020167 2020817 D residues 2 to 205 of 217 are 92.64 pct identical to residues 1 to 204 of 216 from Escherichia coli K-12 : B1973; hypothetical protein 2020167..2020817 Shigella flexneri 2a str. 2457T 1078431 NP_837582.1 CDS S2118 NC_004741.1 2021895 2022164 R residues 1 to 77 of 89 are 92.20 pct identical to residues 1 to 77 of 82 from GenPept : >gb|AAG56015.1|AE005334_2 (AE005334) unknown protein encoded by prophage CP-933X [Escherichia coli O157:H7 EDL933]; bacteriophage protein complement(2021895..2022164) Shigella flexneri 2a str. 2457T 1078432 NP_837583.1 CDS ipaH_5 NC_004741.1 2023205 2024848 D residues 1 to 547 of 547 are 72.48 pct identical to residues 1 to 565 of 565 from NRprotein_Feb03 : >ref|NP_085238.1| invasion plasmid antigen [Shigella flexneri] emb|CAC05787.1| IpaH7.8, member of the IpaH family, secreted by the Mxi-Spa secretion machinery, function unknown [Shigella flexneri]; invasion plasmid antigen 2023205..2024848 Shigella flexneri 2a str. 2457T 1078434 NP_837584.1 CDS S2121 NC_004741.1 2025028 2025405 R residues 1 to 125 of 125 are 68.80 pct identical to residues 64 to 188 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein complement(2025028..2025405) Shigella flexneri 2a str. 2457T 1078435 NP_837585.1 CDS S2122 NC_004741.1 2026462 2026737 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2026462..2026737 Shigella flexneri 2a str. 2457T 1078437 NP_837586.1 CDS S2123 NC_004741.1 2026656 2027159 D residues 1 to 97 of 97 are 82.47 pct identical to residues 71 to 167 of 167 from GenPept : >gb|AAK18549.1|AF348706_238 (AF348706) iso-IS1 orfB [Shigella flexneri]; IS1 orfB 2026656..2027159 Shigella flexneri 2a str. 2457T 1078438 NP_837587.1 CDS S2124 NC_004741.1 2027802 2029751 R residues 1 to 649 of 649 are 85.20 pct identical to residues 1 to 649 of 649 from GenPept : >emb|CAC83565.1| (AJ298298) tail protein [Bacteriophage P27]; tail protein complement(2027802..2029751) Shigella flexneri 2a str. 2457T 1078439 NP_837588.1 CDS S2126 NC_004741.1 2029836 2030171 R residues 3 to 111 of 111 are 97.24 pct identical to residues 1 to 109 of 109 from GenPept : >emb|CAC83564.1| (AJ298298) hypothetical protein [Bacteriophage P27]; bacteriophage protein complement(2029836..2030171) Shigella flexneri 2a str. 2457T 1078440 NP_837589.1 CDS S2127 NC_004741.1 2030171 2030527 R residues 1 to 118 of 118 are 98.30 pct identical to residues 1 to 118 of 118 from GenPept : >emb|CAC83563.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein complement(2030171..2030527) Shigella flexneri 2a str. 2457T 1078441 NP_837590.1 CDS S2128 NC_004741.1 2030527 2032023 R residues 1 to 498 of 498 are 91.16 pct identical to residues 1 to 498 of 498 from GenPept : >emb|CAC83562.1| (AJ298298) sheath protein [Bacteriophage P27]; sheath protein complement(2030527..2032023) Shigella flexneri 2a str. 2457T 1078442 NP_837591.1 CDS S2129 NC_004741.1 2032191 2032445 R residues 1 to 83 of 84 are 98.79 pct identical to residues 104 to 186 of 187 from GenPept : >emb|CAC83561.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein complement(2032191..2032445) Shigella flexneri 2a str. 2457T 1078443 NP_837592.1 CDS S2130 NC_004741.1 2032575 2033288 R residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB complement(2032575..2033288) Shigella flexneri 2a str. 2457T 1078445 NP_837593.1 CDS S2131 NC_004741.1 2033429 2033731 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA complement(2033429..2033731) Shigella flexneri 2a str. 2457T 1078446 NP_837594.1 CDS S2133 NC_004741.1 2034606 2034956 R residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAK18528.1|AF348706_217 (AF348706) IS orf [Shigella flexneri]; partial; ISSfl3 orfB complement(2034606..2034956) Shigella flexneri 2a str. 2457T 1078447 NP_837595.1 CDS S2134 NC_004741.1 2034953 2035450 R residues 1 to 165 of 165 are 99.39 pct identical to residues 60 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA complement(2034953..2035450) Shigella flexneri 2a str. 2457T 1078449 NP_837596.1 CDS S2139 NC_004741.1 2036742 2037425 R residues 1 to 227 of 227 are 92.95 pct identical to residues 1 to 227 of 229 from GenPept : >gb|AAK16973.1|AE006460_11 (AE006460) Q antiterminator encoded by prophage CP-933P [Escherichia coli O157:H7 EDL933]; Q antiterminator of prophage complement(2036742..2037425) Shigella flexneri 2a str. 2457T 1076436 NP_837597.1 CDS S2140 NC_004741.1 2037422 2037787 R residues 4 to 121 of 121 are 96.61 pct identical to residues 2 to 119 of 119 from GenPept : >gb|AAK16974.1|AE006460_12 (AE006460) endonuclease encoded by cryptic prophage CP-933P [Escherichia coli O157:H7 EDL933]; crossover junction endodeoxyribonuclease complement(2037422..2037787) Shigella flexneri 2a str. 2457T 1078451 NP_837598.1 CDS S2142 NC_004741.1 2037788 2038774 R residues 1 to 324 of 328 are 79.32 pct identical to residues 25 to 347 of 348 from GenPept : >dbj|BAB35199.1| (AP002556) hypothetical protein [Escherichia coli O157:H7]; hypothetical protein complement(2037788..2038774) Shigella flexneri 2a str. 2457T 1078452 NP_837599.1 CDS S2141 NC_004741.1 2038773 2039252 D residues 53 to 159 of 159 are 96.26 pct identical to residues 1 to 107 of 107 from GenPept : >gb|AAG57026.1|AE005422_1 (AE005422) unknown protein encoded within prophage CP-933U [Escherichia coli O157:H7 EDL933]; hypothetical protein 2038773..2039252 Shigella flexneri 2a str. 2457T 1079750 NP_837600.1 CDS S2143 NC_004741.1 2039294 2039506 R residues 1 to 70 of 70 are 81.42 pct identical to residues 1 to 70 of 70 from GenPept : >gb|AAK16976.1|AE006461_1 (AE006461) cell killing protein encoded within cryptic prophage CP-933P [Escherichia coli O157:H7 EDL933]; cell killing protein of prophage complement(2039294..2039506) Shigella flexneri 2a str. 2457T 1078453 NP_837601.1 CDS S2144 NC_004741.1 2040101 2040436 R residues 4 to 93 of 111 are 37.25 pct identical to residues 28 to 122 of 151 from GenPept : >dbj|BAB12619.1| (AP002527) ycgB [Escherichia coli]; hypothetical protein complement(2040101..2040436) Shigella flexneri 2a str. 2457T 1078454 NP_837602.1 CDS S2145 NC_004741.1 2040562 2040684 D residues 1 to 40 of 40 are 85.00 pct identical to residues 28 to 67 of 67 from GenPept : >dbj|BAB36195.1| (AP002559) hypothetical protein [Escherichia coli O157:H7]; hypothetical protein 2040562..2040684 Shigella flexneri 2a str. 2457T 1080982 NP_837603.1 CDS S2146 NC_004741.1 2040864 2041709 D residues 1 to 281 of 281 are 93.23 pct identical to residues 60 to 340 of 340 from GenPept : >gb|AAG57039.1|AE005423_1 (AE005423) integrase for prophage CP-933U [Escherichia coli O157:H7 EDL933]; integrase for prophage CP-933U 2040864..2041709 Shigella flexneri 2a str. 2457T 1078455 NP_837604.1 CDS S2148 NC_004741.1 2041906 2042742 D residues 1 to 278 of 278 are 98.92 pct identical to residues 1 to 278 of 278 from Escherichia coli K-12 : B1976; hypothetical protein 2041906..2042742 Shigella flexneri 2a str. 2457T 1078468 NP_837605.1 CDS S2152 NC_004741.1 2043593 2044342 D residues 1 to 249 of 249 are 95.18 pct identical to residues 56 to 304 of 304 from GenPept : >emb|CAB59975.1| (AJ245585) integrase [Escherichia coli]; integrase 2043593..2044342 Shigella flexneri 2a str. 2457T 1079040 NP_837606.1 CDS S2155 NC_004741.1 2045315 2045545 R residues 1 to 76 of 76 are 98.68 pct identical to residues 37 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS911 orfA complement(2045315..2045545) Shigella flexneri 2a str. 2457T 1078240 NP_837607.1 CDS S2157 NC_004741.1 2046243 2046545 D residues 1 to 100 of 100 are 99.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAK18566.1|AF348706_255 (AF348706) IS600 orfA [Shigella flexneri]; IS600 orfA 2046243..2046545 Shigella flexneri 2a str. 2457T 1078462 NP_837608.1 CDS S2158 NC_004741.1 2046686 2047399 D residues 1 to 237 of 237 are 99.57 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72454.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 2046686..2047399 Shigella flexneri 2a str. 2457T 1078463 NP_837609.1 CDS amn NC_004741.1 2047751 2049205 D Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2047751..2049205 Shigella flexneri 2a str. 2457T 1078465 NP_837610.1 CDS S2161 NC_004741.1 2049548 2050264 D residues 1 to 238 of 238 are 99.57 pct identical to residues 1 to 238 of 238 from Escherichia coli K-12 : B1983; hypothetical protein 2049548..2050264 Shigella flexneri 2a str. 2457T 1078466 NP_837611.1 CDS cbl NC_004741.1 2052641 2053591 R LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl complement(2052641..2053591) Shigella flexneri 2a str. 2457T 1078471 NP_837612.1 CDS nac NC_004741.1 2053693 2054610 R Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator complement(2053693..2054610) Shigella flexneri 2a str. 2457T 1078472 NP_837613.1 CDS erfK NC_004741.1 2055069 2056004 R residues 2 to 311 of 311 are 97.41 pct identical to residues 1 to 310 of 310 from Escherichia coli K-12 : B1990; hypothetical protein complement(2055069..2056004) Shigella flexneri 2a str. 2457T 1078474 NP_837614.1 CDS cobT NC_004741.1 2056066 2057145 R catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase complement(2056066..2057145) Shigella flexneri 2a str. 2457T 1078475 NP_837615.1 CDS cobS NC_004741.1 2057157 2057900 R catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase complement(2057157..2057900) Shigella flexneri 2a str. 2457T 1078504 NP_837616.1 CDS S2172 NC_004741.1 2058418 2059131 R residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB complement(2058418..2059131) Shigella flexneri 2a str. 2457T 1078502 NP_837617.1 CDS S2173 NC_004741.1 2059272 2059574 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA complement(2059272..2059574) Shigella flexneri 2a str. 2457T 1078478 NP_837618.1 CDS is629a NC_004741.1 2059817 2060143 D residues 1 to 108 of 108 are 89.81 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72412.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA 2059817..2060143 Shigella flexneri 2a str. 2457T 1078483 NP_837619.1 CDS is629b NC_004741.1 2060379 2061026 D residues 1 to 215 of 215 are 99.06 pct identical to residues 8 to 222 of 222 from GenPept : >gb|AAL72361.1| (AF386526) transposase [Shigella flexneri 2a]; IS629 orfB 2060379..2061026 Shigella flexneri 2a str. 2457T 1078484 NP_837620.1 CDS yeeX NC_004741.1 2061887 2062282 R residues 1 to 131 of 131 are 100.00 pct identical to residues 1 to 131 of 131 from Escherichia coli K-12 : B2007; hypothetical protein complement(2061887..2062282) Shigella flexneri 2a str. 2457T 1078480 NP_837621.1 CDS S2179 NC_004741.1 2062757 2063431 D residues 1 to 224 of 224 are 100.00 pct identical to residues 1 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 2062757..2063431 Shigella flexneri 2a str. 2457T 1078486 NP_837622.1 CDS S2180 NC_004741.1 2063428 2063640 D residues 1 to 57 of 70 are 100.00 pct identical to residues 1 to 57 of 115 from GenPept : >gb|AAL72465.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfB 2063428..2063640 Shigella flexneri 2a str. 2457T 1076977 NP_837623.1 CDS S2181 NC_004741.1 2063643 2064161 R residues 1 to 172 of 172 are 98.83 pct identical to residues 35 to 206 of 206 from GenPept : >gb|AAD44736.1|AF141323_7 (AF141323) TnpC [Shigella flexneri]; IS629 orfA complement(2063643..2064161) Shigella flexneri 2a str. 2457T 1078487 NP_837624.1 CDS S2182 NC_004741.1 2064173 2064526 R residues 1 to 117 of 117 are 100.00 pct identical to residues 1 to 117 of 117 from GenPept : >gb|AAK18555.1|AF348706_244 (AF348706) IS629 orf [Shigella flexneri]; IS629 orfB complement(2064173..2064526) Shigella flexneri 2a str. 2457T 1078507 NP_837625.1 CDS S2184 NC_004741.1 2065084 2066685 D residues 1 to 533 of 533 are 97.37 pct identical to residues 1 to 533 of 533 from GenPept : >gb|AAL72472.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfC 2065084..2066685 Shigella flexneri 2a str. 2457T 1079406 NP_837626.1 CDS S2185 NC_004741.1 2066754 2067068 D residues 13 to 95 of 104 are 34.88 pct identical to residues 325 to 410 of 416 from GenPept : >gb|AAL09885.1| (AY048727) integrase [CRIM helper plasmid pAH129]; hypothetical protein 2066754..2067068 Shigella flexneri 2a str. 2457T 1078488 NP_837627.1 CDS S2187 NC_004741.1 2067528 2067776 R residues 1 to 82 of 82 are 97.56 pct identical to residues 452 to 533 of 533 from GenPept : >gb|AAL72472.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; ISSfl3 orfD complement(2067528..2067776) Shigella flexneri 2a str. 2457T 1078490 NP_837628.1 CDS S2189 NC_004741.1 2068553 2069125 R residues 1 to 190 of 190 are 93.15 pct identical to residues 1 to 190 of 190 from GenPept : >gb|AAK18527.1|AF348706_216 (AF348706) IS orf [Shigella flexneri]; ISSfl3 orfC complement(2068553..2069125) Shigella flexneri 2a str. 2457T 1078811 NP_837629.1 CDS S2190 NC_004741.1 2069122 2069472 R residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAL72462.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfB complement(2069122..2069472) Shigella flexneri 2a str. 2457T 1078491 NP_837630.1 CDS S2191 NC_004741.1 2069469 2069966 R residues 1 to 165 of 165 are 99.39 pct identical to residues 60 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA complement(2069469..2069966) Shigella flexneri 2a str. 2457T 1079728 NP_837631.1 CDS sbcB NC_004741.1 2071243 2072667 D Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2071243..2072667 Shigella flexneri 2a str. 2457T 1078492 NP_837632.1 CDS yeeD NC_004741.1 2072710 2072937 R residues 1 to 75 of 75 are 97.33 pct identical to residues 1 to 75 of 75 from Escherichia coli K-12 : B2012; hypothetical protein complement(2072710..2072937) Shigella flexneri 2a str. 2457T 1078408 NP_837633.1 CDS yeeE NC_004741.1 2072951 2074009 R residues 1 to 352 of 352 are 93.18 pct identical to residues 1 to 352 of 352 from Escherichia coli K-12 : B2013; transport system permease complement(2072951..2074009) Shigella flexneri 2a str. 2457T 1078493 NP_837634.1 CDS yeeF NC_004741.1 2074188 2075546 R residues 1 to 452 of 452 are 89.82 pct identical to residues 3 to 454 of 454 from Escherichia coli K-12 : B2014; amino acid/amine transport protein complement(2074188..2075546) Shigella flexneri 2a str. 2457T 1077380 NP_837635.1 CDS yeeY NC_004741.1 2075759 2076742 R residues 1 to 309 of 327 are 99.35 pct identical to residues 8 to 316 of 316 from Escherichia coli K-12 : B2015; LYSR-type transcriptional regulator complement(2075759..2076742) Shigella flexneri 2a str. 2457T 1078495 NP_837636.1 CDS S2198 NC_004741.1 2076788 2077612 R residues 1 to 274 of 274 are 94.52 pct identical to residues 1 to 274 of 274 from Escherichia coli K-12 : B2016; enzyme of sugar metabolism complement(2076788..2077612) Shigella flexneri 2a str. 2457T 1078496 NP_837637.1 CDS S2199 NC_004741.1 2077971 2078264 R residues 1 to 97 of 97 are 82.47 pct identical to residues 71 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS1 orfB complement(2077971..2078264) Shigella flexneri 2a str. 2457T 1078497 NP_837638.1 CDS S2200 NC_004741.1 2078392 2078667 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(2078392..2078667) Shigella flexneri 2a str. 2457T 1078498 NP_837639.1 CDS yefM NC_004741.1 2078701 2078973 R Antitoxin that counteracts the effect of the YoeB toxin; antitoxin YefM complement(2078701..2078973) Shigella flexneri 2a str. 2457T 1078481 NP_837640.1 CDS hisG NC_004741.1 2079443 2080342 D long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2079443..2080342 Shigella flexneri 2a str. 2457T 1078501 NP_837641.1 CDS hisD NC_004741.1 2080348 2081652 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2080348..2081652 Shigella flexneri 2a str. 2457T 1078511 NP_837642.1 CDS hisC NC_004741.1 2081649 2082719 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2081649..2082719 Shigella flexneri 2a str. 2457T 1078503 NP_837643.1 CDS hisB NC_004741.1 2082719 2083786 D catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2082719..2083786 Shigella flexneri 2a str. 2457T 1078505 NP_837644.1 CDS hisH NC_004741.1 2083786 2084376 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2083786..2084376 Shigella flexneri 2a str. 2457T 1078489 NP_837645.1 CDS hisA NC_004741.1 2084376 2085113 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2084376..2085113 Shigella flexneri 2a str. 2457T 1078508 NP_837646.1 CDS hisF NC_004741.1 2085095 2085871 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2085095..2085871 Shigella flexneri 2a str. 2457T 1076502 NP_837647.1 CDS hisI NC_004741.1 2085865 2086476 D catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP 2085865..2086476 Shigella flexneri 2a str. 2457T 1078510 NP_837648.1 CDS wzzB NC_004741.1 2086662 2087675 R residues 1 to 337 of 337 are 82.24 pct identical to residues 1 to 338 of 338 from Escherichia coli K-12 : B2027; regulator of length of O-antigen component of lipopolysaccharide chains complement(2086662..2087675) Shigella flexneri 2a str. 2457T 1077593 NP_837649.1 CDS gnd NC_004741.1 2089155 2090561 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(2089155..2090561) Shigella flexneri 2a str. 2457T 1078514 NP_837650.1 CDS S2213 NC_004741.1 2090670 2091029 R residues 1 to 119 of 119 are 100.00 pct identical to residues 1 to 119 of 119 from GenPept : >emb|CAA50780.1| (X71970) ORG12x8 [Shigella flexneri]; hypothetical protein complement(2090670..2091029) Shigella flexneri 2a str. 2457T 1078515 NP_837651.1 CDS S2214 NC_004741.1 2091026 2091577 R residues 1 to 183 of 183 are 100.00 pct identical to residues 1 to 183 of 183 from GenPept : >emb|CAA50779.1| (X71970) ORG12x3 [Shigella flexneri]; hypothetical protein complement(2091026..2091577) Shigella flexneri 2a str. 2457T 1078516 NP_837652.1 CDS S2215 NC_004741.1 2091678 2092277 R residues 1 to 199 of 199 are 88.94 pct identical to residues 1 to 199 of 199 from GenPept : >emb|CAA50778.1| (X71970) ORF11x6 [Shigella flexneri]; hypothetical protein complement(2091678..2092277) Shigella flexneri 2a str. 2457T 1078517 NP_837653.1 CDS S2216 NC_004741.1 2092448 2092939 R residues 1 to 163 of 163 are 100.00 pct identical to residues 1 to 163 of 163 from GenPept : >emb|CAA50777.1| (X71970) ORF10x9 [Shigella flexneri]; hypothetical protein complement(2092448..2092939) Shigella flexneri 2a str. 2457T 1078519 NP_837654.1 CDS rfbJ NC_004741.1 2092997 2093386 R residues 1 to 70 of 129 are 100.00 pct identical to residues 1 to 70 of 76 from GenPept : >emb|CAA50776.1| (X71970) rfbJ [Shigella flexneri]; glycosyl transferase complement(2092997..2093386) Shigella flexneri 2a str. 2457T 1078512 NP_837655.1 CDS rfbI NC_004741.1 2093449 2093823 R residues 1 to 124 of 124 are 89.51 pct identical to residues 1 to 124 of 124 from GenPept : >emb|CAA50775.1| (X71970) rfbI [Shigella flexneri]; glycosyl translocase complement(2093449..2093823) Shigella flexneri 2a str. 2457T 1078520 NP_837656.1 CDS rfc NC_004741.1 2093827 2094975 R residues 1 to 382 of 382 are 76.43 pct identical to residues 1 to 382 of 382 from GenPept : >emb|CAA50774.1| (X71970) rfc [Shigella flexneri]; O-antigen polymerase complement(2093827..2094975) Shigella flexneri 2a str. 2457T 1078521 NP_837657.1 CDS rfbG NC_004741.1 2094995 2095864 R residues 1 to 289 of 289 are 100.00 pct identical to residues 1 to 289 of 289 from GenPept : >emb|CAA50773.1| (X71970) rfbG [Shigella flexneri]; dTDP-rhamnosyl transferase complement(2094995..2095864) Shigella flexneri 2a str. 2457T 1078499 NP_837658.1 CDS rfbF NC_004741.1 2095893 2096783 R residues 1 to 296 of 296 are 100.00 pct identical to residues 1 to 296 of 296 from GenPept : >emb|CAA50772.1| (X71970) rfbF [Shigella flexneri]; dTDP-rhamnosyl transferase complement(2095893..2096783) Shigella flexneri 2a str. 2457T 1078523 NP_837659.1 CDS rfbE NC_004741.1 2096813 2098069 R residues 1 to 418 of 418 are 99.52 pct identical to residues 1 to 418 of 418 from GenPept : >emb|CAA50771.1| (X71970) rfbE [Shigella flexneri]; polysaccharide biosynthesis protein complement(2096813..2098069) Shigella flexneri 2a str. 2457T 1078524 NP_837660.1 CDS rfbC NC_004741.1 2098085 2098630 R residues 1 to 181 of 181 are 97.95 pct identical to residues 1 to 181 of 181 from GenPept : >emb|CAA50770.1| (X71970) rfbD [Shigella flexneri]; This protein is named RfbC in SW|P37780|, RfbD in >emb|CAA50770.1|; dTDP-6-deoxy-L-mannose-dehydrogenase complement(2098085..2098630) Shigella flexneri 2a str. 2457T 1078525 NP_837661.1 CDS rfbA NC_004741.1 2098634 2099512 R residues 1 to 290 of 292 are 93.79 pct identical to residues 1 to 290 of 293 from Escherichia coli K-12 : B2039; glucose-1-phosphate thymidylyltransferase complement(2098634..2099512) Shigella flexneri 2a str. 2457T 1078526 NP_837662.1 CDS rfbD NC_004741.1 2099571 2100470 R with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose; dTDP-4-dehydrorhamnose reductase complement(2099571..2100470) Shigella flexneri 2a str. 2457T 1078509 NP_837663.1 CDS rfbB NC_004741.1 2100470 2101555 R NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose; dTDP-glucose 4,6 dehydratase complement(2100470..2101555) Shigella flexneri 2a str. 2457T 1078528 NP_837664.1 CDS galF NC_004741.1 2101928 2102821 R together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalF complement(2101928..2102821) Shigella flexneri 2a str. 2457T 1078506 NP_837665.1 CDS wcaM NC_004741.1 2102996 2104390 R WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; colanic acid biosynthesis protein complement(2102996..2104390) Shigella flexneri 2a str. 2457T 1078529 NP_837666.1 CDS wcaL NC_004741.1 2104401 2105621 R residues 1 to 406 of 406 are 97.29 pct identical to residues 1 to 406 of 406 from Escherichia coli K-12 : B2044; colanic acid biosynthesis glycosyl transferase complement(2104401..2105621) Shigella flexneri 2a str. 2457T 1077666 NP_837667.1 CDS wcaK NC_004741.1 2105618 2106898 R residues 1 to 426 of 426 are 98.12 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 : B2045; pyruvyl transferase complement(2105618..2106898) Shigella flexneri 2a str. 2457T 1078531 NP_837668.1 CDS wzxC NC_004741.1 2107078 2108556 R residues 1 to 492 of 492 are 98.57 pct identical to residues 1 to 492 of 492 from Escherichia coli K-12 : B2046; colanic acid exporter complement(2107078..2108556) Shigella flexneri 2a str. 2457T 1078532 NP_837669.1 CDS wcaJ NC_004741.1 2108558 2109952 R WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; UDP-glucose lipid carrier transferase complement(2108558..2109952) Shigella flexneri 2a str. 2457T 1078535 NP_837670.1 CDS cpsG NC_004741.1 2110007 2111377 R residues 1 to 456 of 456 are 99.12 pct identical to residues 1 to 456 of 456 from Escherichia coli K-12 : B2048; phosphomannomutase complement(2110007..2111377) Shigella flexneri 2a str. 2457T 1078536 NP_837671.1 CDS cpsB NC_004741.1 2111570 2113006 R residues 1 to 478 of 478 are 91.84 pct identical to residues 1 to 478 of 478 from Escherichia coli K-12 : B2049; mannose-1-phosphate guanyltransferase complement(2111570..2113006) Shigella flexneri 2a str. 2457T 1078231 NP_837672.1 CDS wcaI NC_004741.1 2113009 2114232 R residues 1 to 407 of 407 are 95.57 pct identical to residues 1 to 407 of 407 from Escherichia coli K-12 : B2050; glycosyl transferase complement(2113009..2114232) Shigella flexneri 2a str. 2457T 1078537 NP_837673.1 CDS wcaH NC_004741.1 2114229 2114708 R residues 1 to 159 of 159 are 96.85 pct identical to residues 2 to 160 of 160 from Escherichia coli K-12 : B2051; GDP-mannose mannosyl hydrolase complement(2114229..2114708) Shigella flexneri 2a str. 2457T 1078538 NP_837674.1 CDS wcaG NC_004741.1 2114708 2115676 R residues 1 to 321 of 322 are 98.44 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B2052; nucleotide di-P-sugar epimerase or dehydratase complement(2114708..2115676) Shigella flexneri 2a str. 2457T 1076485 NP_837675.1 CDS gmd NC_004741.1 2115679 2116800 R residues 1 to 373 of 373 are 100.00 pct identical to residues 1 to 373 of 373 from Escherichia coli K-12 : B2053; GDP-D-mannose dehydratase complement(2115679..2116800) Shigella flexneri 2a str. 2457T 1078539 NP_837676.1 CDS wcaF NC_004741.1 2116826 2117374 R acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); colanic acid biosynthesis acetyltransferase WcaF complement(2116826..2117374) Shigella flexneri 2a str. 2457T 1078540 NP_837677.1 CDS S2242 NC_004741.1 2117570 2117845 D residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2117570..2117845 Shigella flexneri 2a str. 2457T 1078542 NP_837678.1 CDS S2243 NC_004741.1 2117764 2118267 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 2117764..2118267 Shigella flexneri 2a str. 2457T 1078543 NP_837679.1 CDS wcaB NC_004741.1 2120292 2120780 R acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; colanic acid biosynthesis acetyltransferase WcaB complement(2120292..2120780) Shigella flexneri 2a str. 2457T 1078547 NP_837680.2 CDS S2248 NC_004741.1 2121715 2123877 R Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase complement(2121715..2123877) Shigella flexneri 2a str. 2457T 1078551 NP_837681.1 CDS wzb NC_004741.1 2123880 2124323 R Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase complement(2123880..2124323) Shigella flexneri 2a str. 2457T 1078552 NP_837682.1 CDS wza NC_004741.1 2124329 2125468 R residues 13 to 379 of 379 are 99.72 pct identical to residues 13 to 379 of 379 from Escherichia coli K-12 : B2062; polysaccharide export protein complement(2124329..2125468) Shigella flexneri 2a str. 2457T 1078553 NP_837683.1 CDS yegH NC_004741.1 2126127 2127710 D residues 1 to 527 of 527 are 95.82 pct identical to residues 23 to 549 of 549 from Escherichia coli K-12 : B2063; transporter 2126127..2127710 Shigella flexneri 2a str. 2457T 1078554 NP_837684.1 CDS asmA NC_004741.1 2128159 2130012 R YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; assembly protein complement(2128159..2130012) Shigella flexneri 2a str. 2457T 1078555 NP_837685.1 CDS dcd NC_004741.1 2130034 2130615 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(2130034..2130615) Shigella flexneri 2a str. 2457T 1078006 NP_837686.1 CDS udk NC_004741.1 2130707 2131348 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(2130707..2131348) Shigella flexneri 2a str. 2457T 1078556 NP_837687.1 CDS S2256 NC_004741.1 2132110 2133306 R residues 1 to 398 of 398 are 91.20 pct identical to residues 1 to 398 of 398 from GenPept : >gb|AAL72392.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl4 orf complement(2132110..2133306) Shigella flexneri 2a str. 2457T 1078557 NP_837688.1 CDS alkA NC_004741.1 2136535 2137383 R inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyladenine DNA glycosylase complement(2136535..2137383) Shigella flexneri 2a str. 2457T 1079358 NP_837689.1 CDS S2261 NC_004741.1 2140818 2141579 R residues 1 to 251 of 253 are 90.43 pct identical to residues 1 to 251 of 253 from Escherichia coli K-12 : B2072; hypothetical protein complement(2140818..2141579) Shigella flexneri 2a str. 2457T 1078560 NP_837690.1 CDS S2262 NC_004741.1 2141576 2142235 R residues 1 to 219 of 219 are 90.41 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B2073; hypothetical protein complement(2141576..2142235) Shigella flexneri 2a str. 2457T 1078561 NP_837691.1 CDS issfl4 NC_004741.1 2142669 2143865 D residues 1 to 398 of 398 are 87.43 pct identical to residues 1 to 398 of 398 from GenPept : >gb|AAL72391.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl4 orf 2142669..2143865 Shigella flexneri 2a str. 2457T 1078562 NP_837692.1 CDS yegO NC_004741.1 2148042 2151107 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2148042..2151107 Shigella flexneri 2a str. 2457T 1078565 NP_837693.1 CDS yegB NC_004741.1 2151108 2152523 D residues 1 to 471 of 471 are 85.56 pct identical to residues 1 to 471 of 471 from Escherichia coli K-12 : B2077; multidrug efflux system protein MdtE 2151108..2152523 Shigella flexneri 2a str. 2457T 1078566 NP_837694.1 CDS baeS NC_004741.1 2152520 2153923 D residues 1 to 467 of 467 are 95.07 pct identical to residues 1 to 467 of 467 from Escherichia coli K-12 : B2078; signal transduction histidine-protein kinase BaeS 2152520..2153923 Shigella flexneri 2a str. 2457T 1078567 NP_837695.1 CDS baeR NC_004741.1 2153920 2154642 D response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2153920..2154642 Shigella flexneri 2a str. 2457T 1078568 NP_837696.1 CDS S2270 NC_004741.1 2154794 2155165 D residues 1 to 123 of 123 are 98.37 pct identical to residues 1 to 123 of 123 from Escherichia coli K-12 : B2080; hypothetical protein 2154794..2155165 Shigella flexneri 2a str. 2457T 1078569 NP_837697.1 CDS yegQ NC_004741.1 2155312 2156673 D residues 1 to 453 of 453 are 96.46 pct identical to residues 1 to 453 of 453 from Escherichia coli K-12 : B2081; hypothetical protein 2155312..2156673 Shigella flexneri 2a str. 2457T 1078570 NP_837698.1 CDS S2273 NC_004741.1 2157015 2157392 R residues 1 to 125 of 125 are 87.19 pct identical to residues 1 to 125 of 125 from Escherichia coli K-12 : B2085; hypothetical protein complement(2157015..2157392) Shigella flexneri 2a str. 2457T 1078572 NP_837699.1 CDS S2274 NC_004741.1 2157738 2158637 D cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2157738..2158637 Shigella flexneri 2a str. 2457T 1078573 NP_837700.1 CDS gatR NC_004741.1 2158719 2159498 R residues 1 to 259 of 259 are 99.22 pct identical to residues 1 to 259 of 259 from NRprotein_Feb03 : >ref|NP_416591.1| Galactitol utilization operon repressor [Escherichia coli K12] sp|P36930|GATR_ECOLI Galactitol utilization operon repressor; galactitol utilization operon repressor complement(2158719..2159498) Shigella flexneri 2a str. 2457T 1078575 NP_837701.1 CDS gatD NC_004741.1 2159598 2160638 R Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase complement(2159598..2160638) Shigella flexneri 2a str. 2457T 1078577 NP_837702.1 CDS S2278 NC_004741.1 2160671 2161174 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(2160671..2161174) Shigella flexneri 2a str. 2457T 1078578 NP_837703.1 CDS S2279 NC_004741.1 2161093 2161368 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(2161093..2161368) Shigella flexneri 2a str. 2457T 1078579 NP_837704.1 CDS gatC NC_004741.1 2161463 2162818 R residues 1 to 451 of 451 are 91.35 pct identical to residues 1 to 451 of 451 from Escherichia coli K-12 : B2092; PTS system galactitol-specific enzyme IIC complement(2161463..2162818) Shigella flexneri 2a str. 2457T 1079651 NP_837705.1 CDS gatB NC_004741.1 2162822 2163106 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; galactitol-specific PTS system component IIB complement(2162822..2163106) Shigella flexneri 2a str. 2457T 1078580 NP_837706.1 CDS gatA NC_004741.1 2163137 2163589 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; galactitol-specific PTS system component IIA complement(2163137..2163589) Shigella flexneri 2a str. 2457T 1078581 NP_837707.1 CDS gatZ NC_004741.1 2163599 2164861 R residues 1 to 420 of 420 are 98.57 pct identical to residues 1 to 420 of 420 from Escherichia coli K-12 : B2095; tagatose 6-phosphate kinase 1 complement(2163599..2164861) Shigella flexneri 2a str. 2457T 1078582 NP_837708.1 CDS gatY NC_004741.1 2164890 2165744 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase complement(2164890..2165744) Shigella flexneri 2a str. 2457T 1078583 NP_837709.1 CDS S2285 NC_004741.1 2166052 2167104 R catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase complement(2166052..2167104) Shigella flexneri 2a str. 2457T 1078584 NP_837710.1 CDS S2287 NC_004741.1 2168144 2169109 D residues 1 to 321 of 321 are 88.16 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B2100; kinase 2168144..2169109 Shigella flexneri 2a str. 2457T 1078586 NP_837711.1 CDS yegW NC_004741.1 2169083 2169829 R residues 1 to 248 of 248 are 100.00 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 : B2101; transcriptional regulator complement(2169083..2169829) Shigella flexneri 2a str. 2457T 1077931 NP_837712.1 CDS yegX NC_004741.1 2169877 2170698 R residues 1 to 270 of 273 are 94.44 pct identical to residues 4 to 273 of 275 from Escherichia coli K-12 : B2102; hypothetical protein complement(2169877..2170698) Shigella flexneri 2a str. 2457T 1078587 NP_837713.1 CDS thiD NC_004741.1 2170763 2171563 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(2170763..2171563) Shigella flexneri 2a str. 2457T 1078588 NP_837714.1 CDS thiM NC_004741.1 2171560 2172348 R catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase complement(2171560..2172348) Shigella flexneri 2a str. 2457T 1078589 NP_837715.1 CDS yohL NC_004741.1 2172571 2172843 R residues 1 to 90 of 90 are 100.00 pct identical to residues 1 to 90 of 90 from Escherichia coli K-12 : B2105; hypothetical protein complement(2172571..2172843) Shigella flexneri 2a str. 2457T 1078590 NP_837716.1 CDS yehB NC_004741.1 2175483 2177963 R residues 1 to 826 of 826 are 97.94 pct identical to residues 1 to 826 of 826 from Escherichia coli K-12 : B2109; outer membrane protein complement(2175483..2177963) Shigella flexneri 2a str. 2457T 1078594 NP_837717.1 CDS yehD NC_004741.1 2178734 2179258 R residues 1 to 174 of 174 are 85.00 pct identical to residues 1 to 180 of 180 from Escherichia coli K-12 : B2111; fimbrial-like protein complement(2178734..2179258) Shigella flexneri 2a str. 2457T 1078596 NP_837718.1 CDS S2299 NC_004741.1 2179534 2180037 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(2179534..2180037) Shigella flexneri 2a str. 2457T 1078597 NP_837719.1 CDS S2300 NC_004741.1 2179956 2180231 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(2179956..2180231) Shigella flexneri 2a str. 2457T 1078598 NP_837720.1 CDS yehE NC_004741.1 2180328 2180609 R residues 1 to 93 of 93 are 94.62 pct identical to residues 1 to 93 of 93 from Escherichia coli K-12 : B2112; hypothetical protein complement(2180328..2180609) Shigella flexneri 2a str. 2457T 1078599 NP_837721.1 CDS mrp NC_004741.1 2180871 2181980 R residues 1 to 369 of 369 are 96.47 pct identical to residues 11 to 379 of 379 from Escherichia coli K-12 : B2113; ATPase complement(2180871..2181980) Shigella flexneri 2a str. 2457T 1078600 NP_837722.1 CDS metG NC_004741.1 2182112 2184145 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2182112..2184145 Shigella flexneri 2a str. 2457T 1078601 NP_837723.1 CDS yehL NC_004741.1 2194722 2195876 D residues 1 to 384 of 384 are 98.95 pct identical to residues 1 to 384 of 384 from Escherichia coli K-12 : B2119; hypothetical protein 2194722..2195876 Shigella flexneri 2a str. 2457T 1078608 NP_837724.1 CDS yehM NC_004741.1 2195887 2198166 D residues 1 to 759 of 759 are 89.32 pct identical to residues 1 to 759 of 759 from Escherichia coli K-12 : B2120; hypothetical protein 2195887..2198166 Shigella flexneri 2a str. 2457T 1078609 NP_837725.1 CDS yehP NC_004741.1 2198159 2199295 D residues 1 to 378 of 378 are 98.94 pct identical to residues 1 to 378 of 378 from Escherichia coli K-12 : B2121; hypothetical protein 2198159..2199295 Shigella flexneri 2a str. 2457T 1078611 NP_837726.1 CDS yehQ NC_004741.1 2199292 2201295 D residues 1 to 615 of 667 are 87.64 pct identical to residues 9 to 622 of 622 from Escherichia coli K-12 : B2122; hypothetical protein 2199292..2201295 Shigella flexneri 2a str. 2457T 1078612 NP_837727.1 CDS S2317 NC_004741.1 2201408 2201911 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(2201408..2201911) Shigella flexneri 2a str. 2457T 1078613 NP_837728.1 CDS S2318 NC_004741.1 2201830 2202105 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(2201830..2202105) Shigella flexneri 2a str. 2457T 1078614 NP_837729.1 CDS yehR NC_004741.1 2202196 2202657 D residues 1 to 153 of 153 are 89.54 pct identical to residues 5 to 157 of 157 from Escherichia coli K-12 : B2123; hypothetical protein 2202196..2202657 Shigella flexneri 2a str. 2457T 1078615 NP_837730.1 CDS S2321 NC_004741.1 2202878 2203381 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(2202878..2203381) Shigella flexneri 2a str. 2457T 1078617 NP_837731.1 CDS S2322 NC_004741.1 2203300 2203575 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(2203300..2203575) Shigella flexneri 2a str. 2457T 1078618 NP_837732.1 CDS yehT NC_004741.1 2203991 2204710 R unknown function; when overproduced it confers drug-resistance; two-component response-regulatory protein YehT complement(2203991..2204710) Shigella flexneri 2a str. 2457T 1078619 NP_837733.1 CDS yehU NC_004741.1 2204707 2206392 R residues 1 to 561 of 561 are 95.90 pct identical to residues 1 to 561 of 561 from Escherichia coli K-12 : B2126; 2-component sensor protein complement(2204707..2206392) Shigella flexneri 2a str. 2457T 1078620 NP_837734.1 CDS S2328 NC_004741.1 2208343 2208591 D residues 1 to 82 of 82 are 96.34 pct identical to residues 1 to 82 of 82 from GenPept : >gb|AAG57731.1|AE005491_11 (AE005491) Z3916 gene product [Escherichia coli O157:H7 EDL933]; DNA-damage-inducible protein 2208343..2208591 Shigella flexneri 2a str. 2457T 1078621 NP_837735.1 CDS S2329 NC_004741.1 2208707 2208976 R residues 1 to 77 of 89 are 92.20 pct identical to residues 1 to 77 of 82 from GenPept : >gb|AAG56015.1|AE005334_2 (AE005334) unknown protein encoded by prophage CP-933X [Escherichia coli O157:H7 EDL933]; hypothetical protein complement(2208707..2208976) Shigella flexneri 2a str. 2457T 1080928 NP_837736.1 CDS S2331 NC_004741.1 2211660 2212205 R residues 5 to 146 of 181 are 60.56 pct identical to residues 24 to 165 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein complement(2211660..2212205) Shigella flexneri 2a str. 2457T 1078623 NP_837737.1 CDS S2332 NC_004741.1 2212250 2213584 R residues 1 to 435 of 444 are 39.22 pct identical to residues 35 to 488 of 490 from GenPept : >emb|CAC83574.1| (AJ298298) tail fiber protein [Bacteriophage P27]; phage tail fiber protein complement(2212250..2213584) Shigella flexneri 2a str. 2457T 1078624 NP_837738.1 CDS S2333 NC_004741.1 2213709 2214197 R residues 9 to 162 of 162 are 75.97 pct identical to residues 29 to 182 of 182 from GenPept : >emb|CAC83573.1| (AJ298298) tail fiber assembly protein [Bacteriophage P27]; phage tail fiber assembly protein complement(2213709..2214197) Shigella flexneri 2a str. 2457T 1078625 NP_837739.1 CDS S2334 NC_004741.1 2214257 2214367 R residues 3 to 36 of 36 are 76.47 pct identical to residues 525 to 558 of 558 from GenPept : >dbj|BAA00552.1| (D00660) Bcv gene product [Shigella boydii]; phage tail fiber protein complement(2214257..2214367) Shigella flexneri 2a str. 2457T 1078626 NP_837740.1 CDS S2335 NC_004741.1 2214712 2214987 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2214712..2214987 Shigella flexneri 2a str. 2457T 1078627 NP_837741.1 CDS S2336 NC_004741.1 2214906 2215409 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 B 2214906..2215409 Shigella flexneri 2a str. 2457T 1078628 NP_837742.1 CDS S2337 NC_004741.1 2216108 2216434 D residues 1 to 108 of 108 are 89.81 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72412.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA 2216108..2216434 Shigella flexneri 2a str. 2457T 1078629 NP_837743.1 CDS S2338 NC_004741.1 2216670 2217317 D residues 1 to 215 of 215 are 98.13 pct identical to residues 8 to 222 of 222 from GenPept : >gb|AAL72361.1| (AF386526) transposase [Shigella flexneri 2a]; partial; IS629 orfB 2216670..2217317 Shigella flexneri 2a str. 2457T 1078630 NP_837744.1 CDS S2340 NC_004741.1 2217368 2217682 R no significant similarities; hypothetical protein complement(2217368..2217682) Shigella flexneri 2a str. 2457T 1078632 NP_837745.1 CDS S2341 NC_004741.1 2217875 2217982 D residues 1 to 35 of 35 are 88.57 pct identical to residues 1 to 35 of 35 from GenPept : >gb|AAL21065.1| (AE008796) inner membrane protein [Salmonella typhimurium LT2]; hypothetical protein 2217875..2217982 Shigella flexneri 2a str. 2457T 1078633 NP_837746.1 CDS yehW NC_004741.1 2217963 2218694 R residues 1 to 243 of 243 are 88.47 pct identical to residues 1 to 243 of 243 from Escherichia coli K-12 : B2128; transport system permease complement(2217963..2218694) Shigella flexneri 2a str. 2457T 1078634 NP_837747.1 CDS yehX NC_004741.1 2218699 2219625 R residues 1 to 308 of 308 are 94.48 pct identical to residues 1 to 308 of 308 from Escherichia coli K-12 : B2129; ATP-binding component of a transport system complement(2218699..2219625) Shigella flexneri 2a str. 2457T 1078636 NP_837748.1 CDS yehY NC_004741.1 2219618 2220775 R residues 1 to 385 of 385 are 77.66 pct identical to residues 1 to 385 of 385 from Escherichia coli K-12 : B2130; transport system permease complement(2219618..2220775) Shigella flexneri 2a str. 2457T 1078637 NP_837749.1 CDS yehZ NC_004741.1 2220782 2221699 R residues 1 to 305 of 305 are 97.70 pct identical to residues 1 to 305 of 305 from Escherichia coli K-12 : B2131; transport system permease complement(2220782..2221699) Shigella flexneri 2a str. 2457T 1078214 NP_837750.1 CDS bglX NC_004741.1 2221951 2224248 R residues 1 to 765 of 765 are 99.21 pct identical to residues 1 to 765 of 765 from Escherichia coli K-12 : B2132; periplasmic; beta-D-glucoside glucohydrolase complement(2221951..2224248) Shigella flexneri 2a str. 2457T 1078639 NP_837751.1 CDS dld NC_004741.1 2224444 2226159 D component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2224444..2226159 Shigella flexneri 2a str. 2457T 1080942 NP_837752.2 CDS pbpG NC_004741.1 2226197 2227138 R specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase complement(2226197..2227138) Shigella flexneri 2a str. 2457T 1078640 NP_837753.1 CDS yohC NC_004741.1 2227303 2227890 R residues 1 to 195 of 195 are 92.30 pct identical to residues 9 to 203 of 203 from Escherichia coli K-12 : B2135; hypothetical protein complement(2227303..2227890) Shigella flexneri 2a str. 2457T 1078641 NP_837754.1 CDS yohD NC_004741.1 2228024 2228638 D residues 1 to 204 of 204 are 84.31 pct identical to residues 1 to 204 of 204 from Escherichia coli K-12 : B2136; hypothetical protein 2228024..2228638 Shigella flexneri 2a str. 2457T 1078642 NP_837755.1 CDS yohI NC_004741.1 2231683 2232630 R residues 1 to 315 of 315 are 99.36 pct identical to residues 1 to 315 of 315 from Escherichia coli K-12 : B2140; tRNA-dihydrouridine synthase C complement(2231683..2232630) Shigella flexneri 2a str. 2457T 1076447 NP_837756.1 CDS yohJ NC_004741.1 2232869 2233267 D residues 1 to 132 of 132 are 81.81 pct identical to residues 1 to 132 of 132 from Escherichia coli K-12 : B2141; hypothetical protein 2232869..2233267 Shigella flexneri 2a str. 2457T 1078646 NP_837757.1 CDS yohK NC_004741.1 2233264 2233959 D residues 1 to 231 of 231 are 93.50 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 : B2142; hypothetical protein 2233264..2233959 Shigella flexneri 2a str. 2457T 1078647 NP_837758.1 CDS cdd NC_004741.1 2234089 2234973 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2234089..2234973 Shigella flexneri 2a str. 2457T 1078648 NP_837759.1 CDS sanA NC_004741.1 2235123 2235842 D residues 1 to 239 of 239 are 92.46 pct identical to residues 1 to 239 of 239 from Escherichia coli K-12 : B2144; hypothetical protein 2235123..2235842 Shigella flexneri 2a str. 2457T 1078650 NP_837760.1 CDS S2359 NC_004741.1 2235845 2236084 D residues 1 to 79 of 79 are 86.07 pct identical to residues 1 to 79 of 79 from Escherichia coli K-12 : B2145; hypothetical protein 2235845..2236084 Shigella flexneri 2a str. 2457T 1078651 NP_837761.1 CDS S2360 NC_004741.1 2236278 2237516 D function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 2236278..2237516 Shigella flexneri 2a str. 2457T 1076429 NP_837762.1 CDS mglC NC_004741.1 2238759 2239769 R ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component complement(2238759..2239769) Shigella flexneri 2a str. 2457T 1078653 NP_837763.1 CDS mglA NC_004741.1 2239785 2241305 R with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein complement(2239785..2241305) Shigella flexneri 2a str. 2457T 1078654 NP_837764.1 CDS mglB NC_004741.1 2241366 2242364 R residues 1 to 332 of 332 are 95.48 pct identical to residues 1 to 332 of 332 from Escherichia coli K-12 : B2150; galactose-binding transport protein; receptor for galactose taxis complement(2241366..2242364) Shigella flexneri 2a str. 2457T 1078655 NP_837765.1 CDS galS NC_004741.1 2242644 2243684 R negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS complement(2242644..2243684) Shigella flexneri 2a str. 2457T 1078657 NP_837766.1 CDS yeiB NC_004741.1 2243826 2244902 R residues 1 to 358 of 358 are 79.74 pct identical to residues 1 to 385 of 385 from Escherichia coli K-12 : B2152; hypothetical protein complement(2243826..2244902) Shigella flexneri 2a str. 2457T 1078658 NP_837767.1 CDS folE NC_004741.1 2244919 2245587 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(2244919..2245587) Shigella flexneri 2a str. 2457T 1078659 NP_837768.1 CDS lysP NC_004741.1 2248995 2250464 R residues 1 to 489 of 489 are 96.93 pct identical to residues 1 to 489 of 489 from Escherichia coli K-12 : B2156; lysine transporter complement(2248995..2250464) Shigella flexneri 2a str. 2457T 1077856 NP_837769.1 CDS yeiE NC_004741.1 2250670 2251551 R residues 1 to 293 of 293 are 93.85 pct identical to residues 1 to 293 of 293 from Escherichia coli K-12 : B2157; DNA-binding transcriptional regulator complement(2250670..2251551) Shigella flexneri 2a str. 2457T 1078664 NP_837770.1 CDS yeiH NC_004741.1 2251650 2252699 D residues 1 to 349 of 349 are 84.81 pct identical to residues 1 to 349 of 349 from Escherichia coli K-12 : B2158; hypothetical protein 2251650..2252699 Shigella flexneri 2a str. 2457T 1078665 NP_837771.1 CDS nfo NC_004741.1 2252773 2253630 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2252773..2253630 Shigella flexneri 2a str. 2457T 1078666 NP_837772.1 CDS yeiI NC_004741.1 2253633 2254721 D residues 1 to 362 of 362 are 97.79 pct identical to residues 1 to 362 of 362 from Escherichia coli K-12 : B2160; hypothetical protein 2253633..2254721 Shigella flexneri 2a str. 2457T 1078668 NP_837773.1 CDS yeiJ NC_004741.1 2254777 2256027 R residues 1 to 416 of 416 are 95.67 pct identical to residues 1 to 416 of 416 from Escherichia coli K-12 : B2161; transport system permease complement(2254777..2256027) Shigella flexneri 2a str. 2457T 1078669 NP_837774.1 CDS rihB NC_004741.1 2256127 2257068 R Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 complement(2256127..2257068) Shigella flexneri 2a str. 2457T 1078670 NP_837775.1 CDS yeiL NC_004741.1 2257238 2257816 D activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2257238..2257816 Shigella flexneri 2a str. 2457T 1078671 NP_837776.1 CDS yeiM NC_004741.1 2257964 2259214 R residues 1 to 416 of 416 are 93.99 pct identical to residues 1 to 416 of 416 from Escherichia coli K-12 : B2164; transport system permease complement(2257964..2259214) Shigella flexneri 2a str. 2457T 1078674 NP_837777.1 CDS yeiN NC_004741.1 2259308 2260246 R residues 1 to 312 of 312 are 97.75 pct identical to residues 1 to 312 of 312 from Escherichia coli K-12 : B2165; hypothetical protein complement(2259308..2260246) Shigella flexneri 2a str. 2457T 1079023 NP_837778.1 CDS yeiC NC_004741.1 2260234 2261175 R residues 1 to 313 of 313 are 98.72 pct identical to residues 1 to 313 of 313 from Escherichia coli K-12 : B2166; hypothetical protein complement(2260234..2261175) Shigella flexneri 2a str. 2457T 1078675 NP_837779.1 CDS fruA NC_004741.1 2261599 2263290 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; fructose-specific PTS system IIBC component complement(2261599..2263290) Shigella flexneri 2a str. 2457T 1078677 NP_837780.1 CDS fruK NC_004741.1 2263307 2264245 R converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase complement(2263307..2264245) Shigella flexneri 2a str. 2457T 1078679 NP_837781.1 CDS fruB NC_004741.1 2264245 2265375 R phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional fructose-specific PTS IIA/HPr protein complement(2264245..2265375) Shigella flexneri 2a str. 2457T 1078203 NP_837782.1 CDS yeiO NC_004741.1 2265743 2266921 D residues 1 to 388 of 392 are 94.32 pct identical to residues 1 to 388 of 393 from Escherichia coli K-12 : B2170; transport 2265743..2266921 Shigella flexneri 2a str. 2457T 1078680 NP_837783.1 CDS S2385 NC_004741.1 2266915 2267418 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(2266915..2267418) Shigella flexneri 2a str. 2457T 1079469 NP_837784.1 CDS S2386 NC_004741.1 2267337 2267612 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(2267337..2267612) Shigella flexneri 2a str. 2457T 1078681 NP_837785.2 CDS yeiP NC_004741.1 2268106 2268678 D Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2268106..2268678 Shigella flexneri 2a str. 2457T 1079297 NP_837786.1 CDS yeiQ NC_004741.1 2268901 2270367 D residues 1 to 488 of 488 are 97.95 pct identical to residues 1 to 488 of 488 from Escherichia coli K-12 : B2172; oxidoreductase 2268901..2270367 Shigella flexneri 2a str. 2457T 1078243 NP_837787.1 CDS yeiR NC_004741.1 2270485 2271471 D residues 1 to 328 of 328 are 96.03 pct identical to residues 1 to 328 of 328 from Escherichia coli K-12 : B2173; hypothetical protein 2270485..2271471 Shigella flexneri 2a str. 2457T 1078683 NP_837788.1 CDS S2390 NC_004741.1 2271510 2272223 D residues 1 to 237 of 237 are 98.73 pct identical to residues 13 to 249 of 249 from Escherichia coli K-12 : B2174; hypothetical protein 2271510..2272223 Shigella flexneri 2a str. 2457T 1076536 NP_837789.1 CDS spr NC_004741.1 2272635 2273201 D by similarity, Spr seems to have peptidase activity; involved in thermoresistance; outer membrane lipoprotein 2272635..2273201 Shigella flexneri 2a str. 2457T 1078684 NP_837790.1 CDS rtn NC_004741.1 2273382 2274938 D residues 1 to 518 of 518 are 99.03 pct identical to residues 1 to 518 of 518 from Escherichia coli K-12 : B2176; hypothetical protein 2273382..2274938 Shigella flexneri 2a str. 2457T 1078479 NP_837791.1 CDS yejA NC_004741.1 2275020 2276834 D residues 1 to 604 of 604 are 98.17 pct identical to residues 3 to 606 of 606 from Escherichia coli K-12 : B2177; hypothetical protein 2275020..2276834 Shigella flexneri 2a str. 2457T 1078685 NP_837792.1 CDS yejB NC_004741.1 2276835 2277929 D residues 1 to 364 of 364 are 95.32 pct identical to residues 1 to 364 of 364 from Escherichia coli K-12 : B2178; transport system permease 2276835..2277929 Shigella flexneri 2a str. 2457T 1079658 NP_837793.1 CDS yejE NC_004741.1 2277929 2278954 D residues 1 to 341 of 341 are 93.84 pct identical to residues 1 to 341 of 341 from Escherichia coli K-12 : B2179; transport system permease 2277929..2278954 Shigella flexneri 2a str. 2457T 1078687 NP_837794.1 CDS yejF NC_004741.1 2278956 2280545 D residues 1 to 529 of 529 are 98.86 pct identical to residues 1 to 529 of 529 from Escherichia coli K-12 : B2180; ATP-binding component of a transport system 2278956..2280545 Shigella flexneri 2a str. 2457T 1078686 NP_837795.1 CDS yejG NC_004741.1 2280549 2280893 R residues 1 to 114 of 114 are 100.00 pct identical to residues 1 to 114 of 114 from Escherichia coli K-12 : B2181; hypothetical protein complement(2280549..2280893) Shigella flexneri 2a str. 2457T 1078213 NP_837796.1 CDS bcr NC_004741.1 2281226 2282416 R Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system complement(2281226..2282416) Shigella flexneri 2a str. 2457T 1078690 NP_837797.1 CDS rsuA NC_004741.1 2282444 2283139 R catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A complement(2282444..2283139) Shigella flexneri 2a str. 2457T 1078689 NP_837798.1 CDS yejH NC_004741.1 2283289 2285049 D residues 1 to 586 of 586 are 96.58 pct identical to residues 1 to 586 of 586 from Escherichia coli K-12 : B2184; ATP-dependent helicase 2283289..2285049 Shigella flexneri 2a str. 2457T 1078688 NP_837799.1 CDS rplY NC_004741.1 2285174 2285458 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2285174..2285458 Shigella flexneri 2a str. 2457T 1078692 NP_837800.1 CDS yejK NC_004741.1 2285597 2286604 R residues 1 to 335 of 335 are 92.83 pct identical to residues 1 to 335 of 335 from Escherichia coli K-12 : B2186; nucleoid-associated protein NdpA complement(2285597..2286604) Shigella flexneri 2a str. 2457T 1078691 NP_837801.1 CDS yejL NC_004741.1 2286786 2287013 D residues 1 to 75 of 75 are 97.33 pct identical to residues 1 to 75 of 75 from Escherichia coli K-12 : B2187; hypothetical protein 2286786..2287013 Shigella flexneri 2a str. 2457T 1078693 NP_837802.1 CDS yejM NC_004741.1 2287033 2288793 D residues 1 to 586 of 586 are 93.85 pct identical to residues 1 to 586 of 586 from Escherichia coli K-12 : B2188; sulfatase 2287033..2288793 Shigella flexneri 2a str. 2457T 1078695 NP_837803.1 CDS yejO NC_004741.1 2289047 2291557 R residues 1 to 836 of 836 are 95.09 pct identical to residues 1 to 836 of 836 from Escherichia coli K-12 : B2190; ATP-binding component of a transport system complement(2289047..2291557) Shigella flexneri 2a str. 2457T 1078694 NP_837804.1 CDS narP NC_004741.1 2291958 2292605 D nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2291958..2292605 Shigella flexneri 2a str. 2457T 1078698 NP_837805.1 CDS ccmH NC_004741.1 2292816 2293868 R residues 1 to 350 of 350 are 95.42 pct identical to residues 1 to 350 of 350 from Escherichia coli K-12 : B2194; subunit of heme lyase complement(2292816..2293868) Shigella flexneri 2a str. 2457T 1078699 NP_837806.1 CDS dsbE NC_004741.1 2293865 2294422 R residues 1 to 185 of 185 are 79.45 pct identical to residues 1 to 185 of 185 from Escherichia coli K-12 : B2195; disulfide oxidoreductase complement(2293865..2294422) Shigella flexneri 2a str. 2457T 1078697 NP_837807.1 CDS ccmF NC_004741.1 2294419 2296362 R residues 1 to 647 of 647 are 90.41 pct identical to residues 1 to 647 of 647 from Escherichia coli K-12 : B2196; cytochrome c-type biogenesis protein complement(2294419..2296362) Shigella flexneri 2a str. 2457T 1078702 NP_837808.1 CDS ccmE NC_004741.1 2296359 2296838 R CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE complement(2296359..2296838) Shigella flexneri 2a str. 2457T 1078701 NP_837809.1 CDS ccmD NC_004741.1 2296835 2297044 R residues 1 to 50 of 69 are 63.99 pct identical to residues 1 to 50 of 69 from Escherichia coli K-12 : B2198; heme exporter protein C complement(2296835..2297044) Shigella flexneri 2a str. 2457T 1078700 NP_837810.1 CDS ccmC NC_004741.1 2297041 2297778 R residues 1 to 245 of 245 are 100.00 pct identical to residues 1 to 245 of 245 from Escherichia coli K-12 : B2199; heme exporter protein C complement(2297041..2297778) Shigella flexneri 2a str. 2457T 1078703 NP_837811.1 CDS ccmB NC_004741.1 2297820 2298482 R residues 1 to 220 of 220 are 65.45 pct identical to residues 1 to 220 of 220 from Escherichia coli K-12 : B2200; heme exporter protein B, cytochrome c-type biogenesis protein complement(2297820..2298482) Shigella flexneri 2a str. 2457T 1078704 NP_837812.1 CDS ccmA NC_004741.1 2298479 2299102 R ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA complement(2298479..2299102) Shigella flexneri 2a str. 2457T 1078706 NP_837813.1 CDS napC NC_004741.1 2299115 2299717 R with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC complement(2299115..2299717) Shigella flexneri 2a str. 2457T 1078708 NP_837814.1 CDS napB NC_004741.1 2299727 2300176 R small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit complement(2299727..2300176) Shigella flexneri 2a str. 2457T 1078707 NP_837815.1 CDS napH NC_004741.1 2300173 2301036 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component complement(2300173..2301036) Shigella flexneri 2a str. 2457T 1078705 NP_837816.1 CDS napG NC_004741.1 2301023 2301718 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component complement(2301023..2301718) Shigella flexneri 2a str. 2457T 1078711 NP_837817.1 CDS napA NC_004741.1 2301725 2304211 R periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit complement(2301725..2304211) Shigella flexneri 2a str. 2457T 1078710 NP_837818.1 CDS napD NC_004741.1 2304208 2304471 R residues 1 to 87 of 87 are 100.00 pct identical to residues 1 to 87 of 87 from Escherichia coli K-12 : B2207; assembly protein for periplasmic nitrate reductase complement(2304208..2304471) Shigella flexneri 2a str. 2457T 1078709 NP_837819.1 CDS napF NC_004741.1 2304461 2304955 R Predicted role in electron transfer to the periplasmic nitrate reductase NapA.; ferredoxin-type protein complement(2304461..2304955) Shigella flexneri 2a str. 2457T 1078713 NP_837820.1 CDS eco NC_004741.1 2305363 2305851 D residues 1 to 162 of 162 are 90.12 pct identical to residues 1 to 162 of 162 from Escherichia coli K-12 : B2209; ecotin 2305363..2305851 Shigella flexneri 2a str. 2457T 1078714 NP_837821.1 CDS yojI NC_004741.1 2307815 2309458 R efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding component complement(2307815..2309458) Shigella flexneri 2a str. 2457T 1078718 NP_837822.1 CDS alkB NC_004741.1 2309534 2310184 R residues 1 to 216 of 216 are 98.61 pct identical to residues 1 to 216 of 216 from Escherichia coli K-12 : B2212; alkylated DNA repair protein complement(2309534..2310184) Shigella flexneri 2a str. 2457T 1078717 NP_837823.1 CDS ada NC_004741.1 2310184 2311248 R residues 1 to 354 of 354 are 92.37 pct identical to residues 1 to 354 of 354 from Escherichia coli K-12 : B2213; O6-methylguanine-DNA methyltransferase; transcription activator/repressor complement(2310184..2311248) Shigella flexneri 2a str. 2457T 1078716 NP_837824.1 CDS yojL NC_004741.1 2311322 2312377 R catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE complement(2311322..2312377) Shigella flexneri 2a str. 2457T 1078715 NP_837825.1 CDS ompC NC_004741.1 2312489 2313610 R allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C complement(2312489..2313610) Shigella flexneri 2a str. 2457T 1078720 NP_837826.1 CDS yojN NC_004741.1 2314348 2317020 D residues 1 to 890 of 890 are 92.47 pct identical to residues 1 to 890 of 890 from Escherichia coli K-12 : B2216; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2314348..2317020 Shigella flexneri 2a str. 2457T 1078722 NP_837827.1 CDS rcsB NC_004741.1 2317037 2317687 D two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2317037..2317687 Shigella flexneri 2a str. 2457T 1078723 NP_837828.1 CDS rcsC NC_004741.1 2317887 2320736 R residues 17 to 949 of 949 are 94.31 pct identical to residues 1 to 933 of 933 from Escherichia coli K-12 : B2218; hybrid sensory kinase in two-component regulatory system with RcsB and YojN complement(2317887..2320736) Shigella flexneri 2a str. 2457T 1078721 NP_837829.1 CDS S2434 NC_004741.1 2321011 2321787 R residues 1 to 258 of 258 are 94.18 pct identical to residues 1 to 258 of 258 from Escherichia coli K-12 : B2225; hypothetical protein complement(2321011..2321787) Shigella flexneri 2a str. 2457T 1078726 NP_837830.1 CDS S2435 NC_004741.1 2321792 2323441 R residues 1 to 549 of 549 are 97.08 pct identical to residues 1 to 549 of 549 from Escherichia coli K-12 : B2226; hypothetical protein complement(2321792..2323441) Shigella flexneri 2a str. 2457T 1078725 NP_837831.1 CDS S2436 NC_004741.1 2323442 2323957 R residues 12 to 171 of 171 are 99.37 pct identical to residues 2 to 161 of 161 from Escherichia coli K-12 : B2227; hypothetical protein complement(2323442..2323957) Shigella flexneri 2a str. 2457T 1078724 NP_837832.1 CDS S2438 NC_004741.1 2325716 2326342 R residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB complement(2325716..2326342) Shigella flexneri 2a str. 2457T 1078728 NP_837833.1 CDS S2440 NC_004741.1 2326582 2326884 R residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA complement(2326582..2326884) Shigella flexneri 2a str. 2457T 1078731 NP_837834.1 CDS S2442 NC_004741.1 2329233 2329856 R residues 1 to 207 of 207 are 98.55 pct identical to residues 10 to 216 of 216 from Escherichia coli K-12 : B2229; hypothetical protein complement(2329233..2329856) Shigella flexneri 2a str. 2457T 1078732 NP_837835.1 CDS gyrA NC_004741.1 2331690 2334317 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(2331690..2334317) Shigella flexneri 2a str. 2457T 1078730 NP_837836.1 CDS ubiG NC_004741.1 2334464 2335186 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2334464..2335186 Shigella flexneri 2a str. 2457T 1078729 NP_837837.1 CDS S2447 NC_004741.1 2338932 2339342 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2338932..2339342 Shigella flexneri 2a str. 2457T 1078736 NP_837838.2 CDS S2448 NC_004741.1 2339300 2340205 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2339300..2340205 Shigella flexneri 2a str. 2457T 1078738 NP_837839.1 CDS nrdA NC_004741.1 2341076 2343361 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2341076..2343361 Shigella flexneri 2a str. 2457T 1078737 NP_837840.2 CDS nrdB NC_004741.1 2343595 2344725 D B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2343595..2344725 Shigella flexneri 2a str. 2457T 1078739 NP_837841.1 CDS yfaE NC_004741.1 2344725 2344979 D plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin 2344725..2344979 Shigella flexneri 2a str. 2457T 1078742 NP_837842.1 CDS inaA NC_004741.1 2345033 2345683 R residues 1 to 216 of 216 are 98.61 pct identical to residues 1 to 216 of 216 from Escherichia coli K-12 : B2237; hypothetical protein complement(2345033..2345683) Shigella flexneri 2a str. 2457T 1078741 NP_837843.1 CDS yfaH NC_004741.1 2345898 2346104 D residues 1 to 68 of 68 are 97.05 pct identical to residues 1 to 68 of 68 from Escherichia coli K-12 : B2238; hypothetical protein 2345898..2346104 Shigella flexneri 2a str. 2457T 1078740 NP_837844.1 CDS glpQ NC_004741.1 2346146 2347222 R hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase complement(2346146..2347222) Shigella flexneri 2a str. 2457T 1078746 NP_837845.1 CDS glpT NC_004741.1 2347227 2348585 R catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter complement(2347227..2348585) Shigella flexneri 2a str. 2457T 1080930 NP_837846.1 CDS glpA NC_004741.1 2348858 2350486 D anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2348858..2350486 Shigella flexneri 2a str. 2457T 1078747 NP_837847.1 CDS glpB NC_004741.1 2350476 2351735 D sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2350476..2351735 Shigella flexneri 2a str. 2457T 1078744 NP_837848.1 CDS glpC NC_004741.1 2351732 2352922 D anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2351732..2352922 Shigella flexneri 2a str. 2457T 1078743 NP_837849.1 CDS yfaD NC_004741.1 2353115 2354065 D residues 1 to 311 of 316 are 90.03 pct identical to residues 1 to 295 of 299 from Escherichia coli K-12 : B2244; hypothetical protein 2353115..2354065 Shigella flexneri 2a str. 2457T 1078751 NP_837850.1 CDS S2460 NC_004741.1 2354106 2354576 R residues 4 to 156 of 156 are 77.77 pct identical to residues 115 to 267 of 267 from Escherichia coli K-12 : B2245; hypothetical protein complement(2354106..2354576) Shigella flexneri 2a str. 2457T 1078750 NP_837851.1 CDS S2461 NC_004741.1 2354631 2355833 R residues 1 to 400 of 400 are 96.24 pct identical to residues 1 to 400 of 400 from Escherichia coli K-12 : B2249; competence damage-inducible protein A complement(2354631..2355833) Shigella flexneri 2a str. 2457T 1078748 NP_837852.1 CDS S2462 NC_004741.1 2355920 2356462 R residues 1 to 180 of 180 are 87.77 pct identical to residues 8 to 187 of 187 from Escherichia coli K-12 : B2250; hypothetical protein complement(2355920..2356462) Shigella flexneri 2a str. 2457T 1078754 NP_837853.1 CDS yfaO NC_004741.1 2356804 2357166 D residues 1 to 120 of 120 are 80.00 pct identical to residues 22 to 141 of 141 from Escherichia coli K-12 : B2251; hypothetical protein 2356804..2357166 Shigella flexneri 2a str. 2457T 1078753 NP_837854.1 CDS ais NC_004741.1 2357205 2357783 R residues 1 to 192 of 192 are 90.62 pct identical to residues 9 to 200 of 200 from Escherichia coli K-12 : B2252; protein induced by aluminum complement(2357205..2357783) Shigella flexneri 2a str. 2457T 1078752 NP_837855.2 CDS S2465 NC_004741.1 2358115 2359254 D catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2358115..2359254 Shigella flexneri 2a str. 2457T 1078758 NP_837856.1 CDS S2466 NC_004741.1 2359258 2360226 D catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2359258..2360226 Shigella flexneri 2a str. 2457T 1078757 NP_837857.1 CDS ybfG NC_004741.1 2360657 2362207 D residues 1 to 516 of 516 are 98.83 pct identical to residues 145 to 660 of 660 from Escherichia coli K-12 : B2255; hypothetical protein 2360657..2362207 Shigella flexneri 2a str. 2457T 1078755 NP_837858.1 CDS S2468 NC_004741.1 2362204 2363094 D residues 1 to 296 of 296 are 95.27 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 : B2256; hypothetical protein 2362204..2363094 Shigella flexneri 2a str. 2457T 1078760 NP_837859.1 CDS arnT NC_004741.1 2363094 2364746 D catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2363094..2364746 Shigella flexneri 2a str. 2457T 1078763 NP_837860.1 CDS S2567 NC_004741.1 2364743 2365078 D residues 1 to 477 of 477 are 99.16 pct identical to residues 1 to 477 of 477 from GenPept : >gb|AAC33123.1| (AF084030) sucrose hydrolase [Escherichia coli]; sucrose-6 phosphate hydrolase 2364743..2365078 Shigella flexneri 2a str. 2457T 1078762 NP_837861.2 CDS S2471 NC_004741.1 2365078 2365464 D residues 1 to 222 of 222 are 86.03 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 : B2258; hypothetical protein 2365078..2365464 Shigella flexneri 2a str. 2457T 1078759 NP_837862.1 CDS menE NC_004741.1 2365835 2367190 R residues 1 to 451 of 451 are 92.90 pct identical to residues 1 to 451 of 451 from Escherichia coli K-12 : B2260; O-succinylbenzoic acid--CoA ligase complement(2365835..2367190) Shigella flexneri 2a str. 2457T 1078765 NP_837863.1 CDS menC NC_004741.1 2367187 2368149 R catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase complement(2367187..2368149) Shigella flexneri 2a str. 2457T 1078764 NP_837864.1 CDS menB NC_004741.1 2368149 2369006 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(2368149..2369006) Shigella flexneri 2a str. 2457T 1078768 NP_837865.1 CDS yfbB NC_004741.1 2369021 2369779 R catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB complement(2369021..2369779) Shigella flexneri 2a str. 2457T 1078767 NP_837866.1 CDS menD NC_004741.1 2369776 2371446 R SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase complement(2369776..2371446) Shigella flexneri 2a str. 2457T 1078771 NP_837867.2 CDS menF NC_004741.1 2371535 2372830 R synthesizes isochorismate acid from chorismate; menaquinone-specific isochorismate synthase complement(2371535..2372830) Shigella flexneri 2a str. 2457T 1076991 NP_837868.1 CDS elaB NC_004741.1 2372909 2373214 R residues 1 to 84 of 101 are 77.38 pct identical to residues 1 to 84 of 101 from Escherichia coli K-12 : B2266; hypothetical protein complement(2372909..2373214) Shigella flexneri 2a str. 2457T 1078770 NP_837869.1 CDS elaA NC_004741.1 2373269 2373730 R residues 1 to 153 of 153 are 100.00 pct identical to residues 1 to 153 of 153 from Escherichia coli K-12 : B2267; hypothetical protein complement(2373269..2373730) Shigella flexneri 2a str. 2457T 1078772 NP_837870.2 CDS elaC NC_004741.1 2373795 2374712 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2373795..2374712 Shigella flexneri 2a str. 2457T 1078773 NP_837871.1 CDS S2482 NC_004741.1 2375148 2375423 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2375148..2375423 Shigella flexneri 2a str. 2457T 1078774 NP_837872.1 CDS S2483 NC_004741.1 2375342 2375845 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2375342..2375845 Shigella flexneri 2a str. 2457T 1078735 NP_837873.2 CDS nuoN NC_004741.1 2377618 2379075 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N complement(2377618..2379075) Shigella flexneri 2a str. 2457T 1078775 NP_837874.1 CDS nuoM NC_004741.1 2379082 2380611 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M complement(2379082..2380611) Shigella flexneri 2a str. 2457T 1078777 NP_837875.1 CDS nuoL NC_004741.1 2380775 2382616 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L complement(2380775..2382616) Shigella flexneri 2a str. 2457T 1078778 NP_837876.1 CDS nuoK NC_004741.1 2382613 2382915 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K complement(2382613..2382915) Shigella flexneri 2a str. 2457T 1078782 NP_837877.1 CDS nuoJ NC_004741.1 2382912 2383466 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J complement(2382912..2383466) Shigella flexneri 2a str. 2457T 1078784 NP_837878.1 CDS nuoI NC_004741.1 2383478 2384020 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(2383478..2384020) Shigella flexneri 2a str. 2457T 1078785 NP_837879.1 CDS nuoH NC_004741.1 2384035 2385012 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(2384035..2385012) Shigella flexneri 2a str. 2457T 1076667 NP_837880.1 CDS nuoG NC_004741.1 2385009 2387735 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(2385009..2387735) Shigella flexneri 2a str. 2457T 1078783 NP_837881.1 CDS nuoF NC_004741.1 2387788 2389125 R shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F complement(2387788..2389125) Shigella flexneri 2a str. 2457T 1078787 NP_837882.1 CDS nuoE NC_004741.1 2389122 2389622 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(2389122..2389622) Shigella flexneri 2a str. 2457T 1078788 NP_837883.1 CDS nuoC NC_004741.1 2389625 2391427 R NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D complement(2389625..2391427) Shigella flexneri 2a str. 2457T 1076920 NP_837884.1 CDS nuoB NC_004741.1 2391521 2392183 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(2391521..2392183) Shigella flexneri 2a str. 2457T 1078089 NP_837885.1 CDS nuoA NC_004741.1 2392199 2392642 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A complement(2392199..2392642) Shigella flexneri 2a str. 2457T 1078789 NP_837886.1 CDS lrhA NC_004741.1 2393273 2394211 R residues 1 to 312 of 312 are 91.98 pct identical to residues 1 to 312 of 312 from Escherichia coli K-12 : B2289; LysR family NADH dehydrogenase transcriptional regulator complement(2393273..2394211) Shigella flexneri 2a str. 2457T 1078790 NP_837887.1 CDS S2501 NC_004741.1 2395130 2396347 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 2395130..2396347 Shigella flexneri 2a str. 2457T 1080077 NP_837888.1 CDS S2502 NC_004741.1 2396431 2397030 D residues 1 to 199 of 199 are 98.99 pct identical to residues 1 to 199 of 199 from Escherichia coli K-12 : B2291; hypothetical protein 2396431..2397030 Shigella flexneri 2a str. 2457T 1078786 NP_837889.1 CDS yfbS NC_004741.1 2397089 2398921 R residues 1 to 610 of 610 are 90.49 pct identical to residues 1 to 610 of 610 from Escherichia coli K-12 : B2292; transporter complement(2397089..2398921) Shigella flexneri 2a str. 2457T 1076659 NP_837890.1 CDS yfbT NC_004741.1 2399008 2399658 R residues 1 to 216 of 216 are 93.05 pct identical to residues 7 to 222 of 222 from Escherichia coli K-12 : B2293; phosphatase complement(2399008..2399658) Shigella flexneri 2a str. 2457T 1078791 NP_837891.1 CDS S2505 NC_004741.1 2399669 2400163 R residues 1 to 164 of 164 are 98.78 pct identical to residues 7 to 170 of 170 from Escherichia coli K-12 : B2294; hypothetical protein complement(2399669..2400163) Shigella flexneri 2a str. 2457T 1078793 NP_837892.1 CDS S2506 NC_004741.1 2400246 2400701 R residues 1 to 151 of 151 are 99.33 pct identical to residues 1 to 151 of 151 from Escherichia coli K-12 : B2295; hypothetical protein complement(2400246..2400701) Shigella flexneri 2a str. 2457T 1078794 NP_837893.1 CDS ackA NC_004741.1 2401039 2402241 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2401039..2402241 Shigella flexneri 2a str. 2457T 1078795 NP_837894.1 CDS pta NC_004741.1 2402316 2404460 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2402316..2404460 Shigella flexneri 2a str. 2457T 1078796 NP_837895.2 CDS yfcC NC_004741.1 2404650 2406170 D residues 1 to 513 of 513 are 99.80 pct identical to residues 1 to 513 of 513 from Escherichia coli K-12 : B2298; hypothetical protein 2404650..2406170 Shigella flexneri 2a str. 2457T 1078797 NP_837896.1 CDS S2510 NC_004741.1 2406203 2406745 R residues 1 to 180 of 180 are 91.11 pct identical to residues 1 to 180 of 180 from Escherichia coli K-12 : B2299; regulator complement(2406203..2406745) Shigella flexneri 2a str. 2457T 1076638 NP_837897.1 CDS yfcE NC_004741.1 2406803 2407354 R residues 1 to 183 of 183 are 97.81 pct identical to residues 2 to 184 of 184 from Escherichia coli K-12 : B2300; phosphodiesterase complement(2406803..2407354) Shigella flexneri 2a str. 2457T 1078792 NP_837898.1 CDS yfcF NC_004741.1 2407410 2408054 R residues 1 to 214 of 214 are 99.53 pct identical to residues 1 to 214 of 214 from Escherichia coli K-12 : B2301; hypothetical protein complement(2407410..2408054) Shigella flexneri 2a str. 2457T 1078800 NP_837899.1 CDS yfcG NC_004741.1 2408190 2408837 D residues 1 to 215 of 215 are 99.06 pct identical to residues 1 to 215 of 215 from Escherichia coli K-12 : B2302; glutathione S-transferase 2408190..2408837 Shigella flexneri 2a str. 2457T 1078801 NP_837900.1 CDS folX NC_004741.1 2408894 2409256 D catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2408894..2409256 Shigella flexneri 2a str. 2457T 1076649 NP_837901.1 CDS S2515 NC_004741.1 2409277 2410170 D residues 1 to 297 of 297 are 99.32 pct identical to residues 1 to 297 of 297 from Escherichia coli K-12 : B2304; sugar nucleotide epimerase 2409277..2410170 Shigella flexneri 2a str. 2457T 1078799 NP_837902.1 CDS yfcI NC_004741.1 2410218 2411108 R residues 1 to 296 of 296 are 98.64 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 : B2305; hypothetical protein complement(2410218..2411108) Shigella flexneri 2a str. 2457T 1078802 NP_837903.1 CDS hisP NC_004741.1 2411305 2412078 R residues 1 to 257 of 257 are 95.71 pct identical to residues 1 to 257 of 257 from Escherichia coli K-12 : B2306; histidine/lysine/arginine/ornithine transporter subunit complement(2411305..2412078) Shigella flexneri 2a str. 2457T 1078805 NP_837904.1 CDS hisM NC_004741.1 2412086 2412802 R residues 1 to 238 of 238 are 87.81 pct identical to residues 1 to 238 of 238 from Escherichia coli K-12 : B2307; histidine transport, membrane protein M complement(2412086..2412802) Shigella flexneri 2a str. 2457T 1076645 NP_837905.1 CDS hisQ NC_004741.1 2412799 2413485 R residues 1 to 228 of 228 are 89.47 pct identical to residues 1 to 228 of 228 from Escherichia coli K-12 : B2308; histidine transport system permease complement(2412799..2413485) Shigella flexneri 2a str. 2457T 1078804 NP_837906.1 CDS hisJ NC_004741.1 2413575 2414357 R residues 1 to 260 of 260 are 91.92 pct identical to residues 1 to 260 of 260 from Escherichia coli K-12 : B2309; histidine-binding periplasmic protein of high-affinity histidine transport system complement(2413575..2414357) Shigella flexneri 2a str. 2457T 1078806 NP_837907.1 CDS argT NC_004741.1 2414578 2415360 R residues 1 to 260 of 260 are 91.15 pct identical to residues 1 to 260 of 260 from Escherichia coli K-12 : B2310; lysine-, arginine-, ornithine-binding periplasmic protein complement(2414578..2415360) Shigella flexneri 2a str. 2457T 1078807 NP_837908.1 CDS ubiX NC_004741.1 2415626 2416195 R catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(2415626..2416195) Shigella flexneri 2a str. 2457T 1078672 NP_837909.1 CDS purF NC_004741.1 2416290 2417807 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(2416290..2417807) Shigella flexneri 2a str. 2457T 1078808 NP_837910.1 CDS cvpA NC_004741.1 2417844 2418332 R membrane protein required for colicin V production; colicin V production protein complement(2417844..2418332) Shigella flexneri 2a str. 2457T 1076655 NP_837911.2 CDS dedD NC_004741.1 2418591 2419253 R residues 1 to 211 of 211 are 67.77 pct identical to residues 1 to 211 of 211 from Escherichia coli K-12 : B2314; hypothetical protein complement(2418591..2419253) Shigella flexneri 2a str. 2457T 1078812 NP_837912.1 CDS folC NC_004741.1 2419243 2420511 R residues 1 to 422 of 422 are 92.89 pct identical to residues 1 to 422 of 422 from Escherichia coli K-12 : B2315; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase complement(2419243..2420511) Shigella flexneri 2a str. 2457T 1078813 NP_837913.1 CDS accD NC_004741.1 2420581 2421495 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(2420581..2421495) Shigella flexneri 2a str. 2457T 1078815 NP_837914.1 CDS dedA NC_004741.1 2421651 2422310 R residues 1 to 210 of 219 are 90.95 pct identical to residues 1 to 210 of 219 from Escherichia coli K-12 : B2317; hypothetical protein complement(2421651..2422310) Shigella flexneri 2a str. 2457T 1076642 NP_837915.1 CDS truA NC_004741.1 2422393 2423205 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(2422393..2423205) Shigella flexneri 2a str. 2457T 1078809 NP_837916.1 CDS usg NC_004741.1 2423205 2424218 R residues 1 to 337 of 337 are 87.53 pct identical to residues 1 to 337 of 337 from Escherichia coli K-12 : B2319; semialdehyde dehydrogenase complement(2423205..2424218) Shigella flexneri 2a str. 2457T 1076658 NP_837917.1 CDS pdxB NC_004741.1 2424284 2425420 R catalyzes the formation of 3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate from erythronate-4-phosphate; erythronate-4-phosphate dehydrogenase complement(2424284..2425420) Shigella flexneri 2a str. 2457T 1078816 NP_837918.1 CDS flk NC_004741.1 2425519 2426514 D in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2425519..2426514 Shigella flexneri 2a str. 2457T 1078817 NP_837919.1 CDS S2533 NC_004741.1 2426511 2427689 R residues 1 to 392 of 392 are 83.16 pct identical to residues 1 to 392 of 392 from Escherichia coli K-12 : B2322; hypothetical protein complement(2426511..2427689) Shigella flexneri 2a str. 2457T 1076682 NP_837920.1 CDS fabB NC_004741.1 2427944 2429185 R FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase complement(2427944..2429185) Shigella flexneri 2a str. 2457T 1078820 NP_837921.2 CDS mnmC NC_004741.1 2429344 2431350 D catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2429344..2431350 Shigella flexneri 2a str. 2457T 1078821 NP_837922.1 CDS S2536 NC_004741.1 2431471 2431749 R residues 1 to 91 of 92 are 100.00 pct identical to residues 1 to 91 of 92 from Escherichia coli K-12 : B2325; hypothetical protein complement(2431471..2431749) Shigella flexneri 2a str. 2457T 1078819 NP_837923.1 CDS S2537 NC_004741.1 2431783 2432331 R residues 1 to 182 of 182 are 98.90 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 : B2326; transporting ATPase complement(2431783..2432331) Shigella flexneri 2a str. 2457T 1078823 NP_837924.1 CDS yfcA NC_004741.1 2432331 2433140 R residues 1 to 269 of 269 are 95.53 pct identical to residues 1 to 269 of 269 from Escherichia coli K-12 : B2327; hypothetical protein complement(2432331..2433140) Shigella flexneri 2a str. 2457T 1078822 NP_837925.1 CDS mepA NC_004741.1 2433140 2433964 R D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase complement(2433140..2433964) Shigella flexneri 2a str. 2457T 1076664 NP_837926.1 CDS aroC NC_004741.1 2433968 2435053 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(2433968..2435053) Shigella flexneri 2a str. 2457T 1078824 NP_837927.1 CDS yfcB NC_004741.1 2435088 2436353 R involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(2435088..2436353) Shigella flexneri 2a str. 2457T 1078825 NP_837928.1 CDS S2541 NC_004741.1 2436186 2436737 D residues 1 to 183 of 183 are 100.00 pct identical to residues 1 to 183 of 183 from Escherichia coli K-12 : B2331; hypothetical protein 2436186..2436737 Shigella flexneri 2a str. 2457T 1078826 NP_837929.1 CDS S2550 NC_004741.1 2442723 2443286 R residues 1 to 187 of 187 are 83.95 pct identical to residues 1 to 187 of 187 from Escherichia coli K-12 : B2339; fimbrial-like protein complement(2442723..2443286) Shigella flexneri 2a str. 2457T 1078834 NP_837930.1 CDS S2551 NC_004741.1 2443555 2444058 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(2443555..2444058) Shigella flexneri 2a str. 2457T 1078835 NP_837931.1 CDS S2552 NC_004741.1 2443977 2444252 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(2443977..2444252) Shigella flexneri 2a str. 2457T 1078836 NP_837932.1 CDS S2553 NC_004741.1 2444747 2445232 R residues 1 to 161 of 161 are 99.37 pct identical to residues 1 to 161 of 161 from Escherichia coli K-12 : B2340; phosphohistidine phosphatase complement(2444747..2445232) Shigella flexneri 2a str. 2457T 1078832 NP_837933.1 CDS fadJ NC_004741.1 2445435 2447579 R multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha complement(2445435..2447579) Shigella flexneri 2a str. 2457T 1076648 NP_837934.1 CDS fadI NC_004741.1 2447579 2448889 R FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase complement(2447579..2448889) Shigella flexneri 2a str. 2457T 1078837 NP_837935.1 CDS S2556 NC_004741.1 2449069 2449377 R residues 1 to 102 of 102 are 86.27 pct identical to residues 1 to 102 of 102 from Escherichia coli K-12 : B2343; hypothetical protein complement(2449069..2449377) Shigella flexneri 2a str. 2457T 1078838 NP_837936.1 CDS fadL NC_004741.1 2449725 2451065 D residues 1 to 446 of 446 are 99.55 pct identical to residues 3 to 448 of 448 from Escherichia coli K-12 : B2344; sensitivity to phage t2; long-chain fatty acid outer membrane transporter 2449725..2451065 Shigella flexneri 2a str. 2457T 1078839 NP_837937.1 CDS S2558 NC_004741.1 2451431 2452489 D residues 1 to 352 of 352 are 88.92 pct identical to residues 1 to 352 of 352 from Escherichia coli K-12 : B2345; hypothetical protein 2451431..2452489 Shigella flexneri 2a str. 2457T 1078840 NP_837938.1 CDS vacJ NC_004741.1 2452671 2453426 R residues 1 to 251 of 251 are 99.20 pct identical to residues 1 to 251 of 251 from Escherichia coli K-12 : B2346; lipoprotein precursor complement(2452671..2453426) Shigella flexneri 2a str. 2457T 1078841 NP_837939.1 CDS yfdC NC_004741.1 2453831 2454652 D residues 1 to 273 of 273 are 87.17 pct identical to residues 38 to 310 of 310 from Escherichia coli K-12 : B2347; transporter 2453831..2454652 Shigella flexneri 2a str. 2457T 1078842 NP_837940.1 CDS S2565 NC_004741.1 2456297 2456599 R residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA complement(2456297..2456599) Shigella flexneri 2a str. 2457T 1078844 NP_837941.1 CDS S2566 NC_004741.1 2456580 2457185 R residues 1 to 191 of 201 are 90.76 pct identical to residues 7 to 201 of 439 from GenPept : >gb|AAK18553.1|AF348706_242 (AF348706) IS4 orf [Shigella flexneri]; partial; IS4 orf complement(2456580..2457185) Shigella flexneri 2a str. 2457T 1078845 NP_837942.1 CDS S2470 NC_004741.1 2457501 2458934 D residues 1 to 111 of 111 are 79.27 pct identical to residues 1 to 111 of 111 from GenPept : >gb|AAG57389.1|AE005458_6 (AE005458) Z3516 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 2457501..2458934 Shigella flexneri 2a str. 2457T 1078846 NP_837943.1 CDS S2568 NC_004741.1 2458942 2460000 R residues 22 to 352 of 352 are 96.37 pct identical to residues 1 to 331 of 331 from GenPept : >emb|CAA57220.1| (X81461) sucrose specific repressor [Escherichia coli]; sucrose specific repressor complement(2458942..2460000) Shigella flexneri 2a str. 2457T 1078338 NP_837944.1 CDS dsdA NC_004741.1 2460404 2461732 D catalyzes the formation of pyruvate from serine; D-serine dehydratase 2460404..2461732 Shigella flexneri 2a str. 2457T 1078849 NP_837945.1 CDS emrY NC_004741.1 2461840 2463378 R residues 1 to 512 of 512 are 89.25 pct identical to residues 1 to 512 of 512 from Escherichia coli K-12 : B2367; multidrug resistance protein Y complement(2461840..2463378) Shigella flexneri 2a str. 2457T 1078852 NP_837946.1 CDS emrK NC_004741.1 2463378 2464541 R residues 1 to 387 of 387 are 94.83 pct identical to residues 1 to 387 of 387 from Escherichia coli K-12 : B2368; multidrug resistance protein K complement(2463378..2464541) Shigella flexneri 2a str. 2457T 1078853 NP_837947.1 CDS evgA NC_004741.1 2464957 2465571 D response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2464957..2465571 Shigella flexneri 2a str. 2457T 1078854 NP_837948.1 CDS evgS NC_004741.1 2465576 2469169 D residues 1 to 1197 of 1197 are 94.23 pct identical to residues 1 to 1197 of 1197 from Escherichia coli K-12 : B2370; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2465576..2469169 Shigella flexneri 2a str. 2457T 1080966 NP_837949.2 CDS yfdE NC_004741.1 2469225 2470409 R residues 1 to 381 of 381 are 98.42 pct identical to residues 14 to 394 of 394 from Escherichia coli K-12 : B2371; hypothetical protein complement(2469225..2470409) Shigella flexneri 2a str. 2457T 1080924 NP_837950.1 CDS S2577 NC_004741.1 2471457 2473151 R catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase complement(2471457..2473151) Shigella flexneri 2a str. 2457T 1076616 NP_837951.1 CDS S2578 NC_004741.1 2473205 2474455 R catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase complement(2473205..2474455) Shigella flexneri 2a str. 2457T 1078850 NP_837952.1 CDS S2579 NC_004741.1 2474968 2475591 R residues 1 to 207 of 207 are 90.99 pct identical to residues 1 to 211 of 211 from Escherichia coli K-12 : B2375; hypothetical protein complement(2474968..2475591) Shigella flexneri 2a str. 2457T 1078857 NP_837953.1 CDS S2580 NC_004741.1 2475888 2476163 D residues 17 to 91 of 91 are 92.00 pct identical to residues 17 to 91 of 91 from Escherichia coli K-12 : B2376; hypothetical protein 2475888..2476163 Shigella flexneri 2a str. 2457T 1076631 NP_837954.1 CDS S2581 NC_004741.1 2476240 2476482 R residues 1 to 80 of 80 are 98.75 pct identical to residues 1 to 80 of 80 from Escherichia coli K-12 : B2377; hypothetical protein complement(2476240..2476482) Shigella flexneri 2a str. 2457T 1078856 NP_837955.2 CDS ddg NC_004741.1 2476835 2477755 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2476835..2477755 Shigella flexneri 2a str. 2457T 1076653 NP_837956.1 CDS S2583 NC_004741.1 2478246 2479484 R residues 1 to 412 of 412 are 99.27 pct identical to residues 1 to 412 of 412 from Escherichia coli K-12 : B2379; aminotransferase complement(2478246..2479484) Shigella flexneri 2a str. 2457T 1078858 NP_837957.1 CDS S2585 NC_004741.1 2481362 2482096 D residues 1 to 244 of 244 are 93.03 pct identical to residues 1 to 244 of 244 from Escherichia coli K-12 : B2381; 2-component transcriptional regulator 2481362..2482096 Shigella flexneri 2a str. 2457T 1078860 NP_837958.1 CDS S2586 NC_004741.1 2482109 2482681 D residues 1 to 190 of 190 are 97.89 pct identical to residues 1 to 190 of 285 from Escherichia coli K-12 : B2382; ARAC-type regulatory protein 2482109..2482681 Shigella flexneri 2a str. 2457T 1078861 NP_837959.1 CDS S2588 NC_004741.1 2482969 2485464 R residues 1 to 831 of 831 are 95.54 pct identical to residues 1 to 831 of 831 from Escherichia coli K-12 : B2383; PTS system enzyme IIA component, enzyme I complement(2482969..2485464) Shigella flexneri 2a str. 2457T 1078863 NP_837960.1 CDS S2589 NC_004741.1 2485489 2486526 R metalloprotein; exoaminopeptidase complement(2485489..2486526) Shigella flexneri 2a str. 2457T 1078865 NP_837961.1 CDS S2591 NC_004741.1 2487624 2488871 R residues 1 to 415 of 415 are 93.25 pct identical to residues 1 to 415 of 415 from Escherichia coli K-12 : B2386; transporter complement(2487624..2488871) Shigella flexneri 2a str. 2457T 1079790 NP_837962.1 CDS S2592 NC_004741.1 2488893 2489219 R residues 1 to 108 of 108 are 88.88 pct identical to residues 1 to 108 of 108 from Escherichia coli K-12 : B2387; PTS system enzyme IIB component complement(2488893..2489219) Shigella flexneri 2a str. 2457T 1078866 NP_837963.1 CDS glk NC_004741.1 2489438 2490403 R catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase complement(2489438..2490403) Shigella flexneri 2a str. 2457T 1078864 NP_837964.1 CDS S2594 NC_004741.1 2490607 2491863 D residues 1 to 418 of 418 are 77.27 pct identical to residues 1 to 418 of 418 from Escherichia coli K-12 : B2389; hypothetical protein 2490607..2491863 Shigella flexneri 2a str. 2457T 1076686 NP_837965.1 CDS S2595 NC_004741.1 2491978 2492304 D residues 1 to 91 of 108 are 81.31 pct identical to residues 1 to 91 of 108 from Escherichia coli K-12 : B2390; hypothetical protein 2491978..2492304 Shigella flexneri 2a str. 2457T 1078867 NP_837967.1 CDS mntH NC_004741.1 2492445 2493683 R residues 1 to 412 of 412 are 99.75 pct identical to residues 1 to 412 of 412 from Escherichia coli K-12 : B2392; manganese transport protein MntH complement(2492445..2493683) Shigella flexneri 2a str. 2457T 1078869 NP_837968.1 CDS nupC NC_004741.1 2494019 2495221 D residues 1 to 400 of 400 are 90.49 pct identical to residues 1 to 400 of 400 from Escherichia coli K-12 : B2393; permease of transport system for 3 nucleosides 2494019..2495221 Shigella flexneri 2a str. 2457T 1078870 NP_837970.1 CDS yfeC NC_004741.1 2498017 2498361 D residues 1 to 114 of 114 are 100.00 pct identical to residues 6 to 119 of 119 from Escherichia coli K-12 : B2398; hypothetical protein 2498017..2498361 Shigella flexneri 2a str. 2457T 1078875 NP_837971.1 CDS yfeD NC_004741.1 2498384 2498755 D residues 1 to 123 of 123 are 99.18 pct identical to residues 8 to 130 of 130 from Escherichia coli K-12 : B2399; hypothetical protein 2498384..2498755 Shigella flexneri 2a str. 2457T 1078876 NP_837972.1 CDS gltX NC_004741.1 2498807 2500222 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(2498807..2500222) Shigella flexneri 2a str. 2457T 1078877 NP_837973.1 CDS flxA NC_004741.1 2501032 2501373 D residues 16 to 88 of 88 are 41.89 pct identical to residues 14 to of 84 from Escherichia coli K-12 : B1566; hypothetical protein 2501032..2501373 Shigella flexneri 2a str. 2457T 1078881 NP_837974.1 CDS yfeR NC_004741.1 2501364 2502290 R residues 1 to 308 of 308 are 88.96 pct identical to residues 1 to 308 of 308 from Escherichia coli K-12 : B2409; LYSR-type transcriptional regulator complement(2501364..2502290) Shigella flexneri 2a str. 2457T 1078882 NP_837975.1 CDS yfeH NC_004741.1 2502380 2503378 D residues 1 to 332 of 332 are 96.08 pct identical to residues 1 to 332 of 332 from Escherichia coli K-12 : B2410; cytochrome oxidase 2502380..2503378 Shigella flexneri 2a str. 2457T 1078883 NP_837976.1 CDS ligA NC_004741.1 2503595 2505610 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(2503595..2505610) Shigella flexneri 2a str. 2457T 1078884 NP_837977.1 CDS zipA NC_004741.1 2505681 2506664 R interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA complement(2505681..2506664) Shigella flexneri 2a str. 2457T 1078885 NP_837978.1 CDS cysZ NC_004741.1 2506897 2507658 D role in sulfur assimilation; sulfate transport protein CysZ 2506897..2507658 Shigella flexneri 2a str. 2457T 1078886 NP_837979.1 CDS cysK NC_004741.1 2507843 2508814 D CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2507843..2508814 Shigella flexneri 2a str. 2457T 1078887 NP_837980.1 CDS ptsH NC_004741.1 2509198 2509455 D residues 1 to 85 of 85 are 100.00 pct identical to residues 1 to 85 of 85 from Escherichia coli K-12 : B2415; phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr) 2509198..2509455 Shigella flexneri 2a str. 2457T 1078888 NP_837981.1 CDS ptsI NC_004741.1 2509500 2511227 D Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2509500..2511227 Shigella flexneri 2a str. 2457T 1078889 NP_837982.1 CDS crr NC_004741.1 2511268 2511777 D functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; glucose-specific PTS system component 2511268..2511777 Shigella flexneri 2a str. 2457T 1078890 NP_837983.1 CDS pdxK NC_004741.1 2511819 2512670 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase complement(2511819..2512670) Shigella flexneri 2a str. 2457T 1078891 NP_837984.1 CDS yfeK NC_004741.1 2512775 2513149 D residues 1 to 124 of 124 are 96.77 pct identical to residues 1 to 124 of 124 from Escherichia coli K-12 : B2419; hypothetical protein 2512775..2513149 Shigella flexneri 2a str. 2457T 1078892 NP_837985.1 CDS cysM NC_004741.1 2514109 2515020 R catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B complement(2514109..2515020) Shigella flexneri 2a str. 2457T 1078894 NP_837986.1 CDS cysA NC_004741.1 2515154 2516251 R residues 1 to 365 of 365 are 99.17 pct identical to residues 1 to 365 of 365 from Escherichia coli K-12 : B2422; sulfate/thiosulfate transporter subunit complement(2515154..2516251) Shigella flexneri 2a str. 2457T 1078895 NP_837987.1 CDS cysW NC_004741.1 2516241 2516690 R residues 1 to 149 of 149 are 88.59 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B2423; sulfate transport system permease W protein complement(2516241..2516690) Shigella flexneri 2a str. 2457T 1078896 NP_837988.1 CDS cysU NC_004741.1 2517116 2517949 R residues 1 to 277 of 277 are 83.03 pct identical to residues 1 to 277 of 277 from Escherichia coli K-12 : B2424; sulfate/thiosulfate transporter subunit complement(2517116..2517949) Shigella flexneri 2a str. 2457T 1078897 NP_837989.1 CDS cysP NC_004741.1 2517949 2518965 R residues 21 to 337 of 338 are 94.95 pct identical to residues 21 to 337 of 338 from Escherichia coli K-12 : B2425; thiosulfate transporter subunit complement(2517949..2518965) Shigella flexneri 2a str. 2457T 1078898 NP_837990.1 CDS ucpA NC_004741.1 2519269 2520060 R residues 1 to 263 of 263 are 98.85 pct identical to residues 23 to 285 of 285 from Escherichia coli K-12 : B2426; short chain dehydrogenase complement(2519269..2520060) Shigella flexneri 2a str. 2457T 1078899 NP_837991.1 CDS yfeT NC_004741.1 2520247 2521047 R residues 1 to 264 of 266 are 96.96 pct identical to residues 1 to 264 of 285 from Escherichia coli K-12 : B2427; hypothetical protein complement(2520247..2521047) Shigella flexneri 2a str. 2457T 1078900 NP_837992.1 CDS murQ NC_004741.1 2521211 2522107 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2521211..2522107 Shigella flexneri 2a str. 2457T 1078901 NP_837993.1 CDS murP NC_004741.1 2522111 2523535 D belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; N-acetylmuramic acid phosphotransfer permease 2522111..2523535 Shigella flexneri 2a str. 2457T 1078902 NP_837994.1 CDS S2632 NC_004741.1 2523715 2524614 R residues 1 to 299 of 299 are 99.33 pct identical to residues 10 to 308 of 308 from Escherichia coli K-12 : B2431; hypothetical protein complement(2523715..2524614) Shigella flexneri 2a str. 2457T 1078904 NP_837995.1 CDS S2633 NC_004741.1 2524710 2525285 R residues 1 to 191 of 191 are 99.47 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B2432; hypothetical protein complement(2524710..2525285) Shigella flexneri 2a str. 2457T 1078905 NP_837996.1 CDS S2634 NC_004741.1 2525346 2525795 R residues 1 to 149 of 149 are 79.19 pct identical to residues 3 to 151 of 151 from Escherichia coli K-12 : B2433; hypothetical protein complement(2525346..2525795) Shigella flexneri 2a str. 2457T 1078906 NP_837997.1 CDS S2635 NC_004741.1 2525782 2526207 R residues 1 to 141 of 141 are 99.29 pct identical to residues 38 to 178 of 178 from Escherichia coli K-12 : B2434; acetyltransferase complement(2525782..2526207) Shigella flexneri 2a str. 2457T 1078908 NP_837998.1 CDS amiA NC_004741.1 2526421 2527290 D residues 1 to 289 of 289 are 95.15 pct identical to residues 1 to 289 of 289 from Escherichia coli K-12 : B2435; N-acetylmuramoyl-l-alanine amidase I 2526421..2527290 Shigella flexneri 2a str. 2457T 1078909 NP_837999.1 CDS yfeG NC_004741.1 2528200 2528760 R residues 1 to 186 of 186 are 97.84 pct identical to residues 165 to 350 of 350 from Escherichia coli K-12 : B2437; ARAC-type regulatory protein complement(2528200..2528760) Shigella flexneri 2a str. 2457T 1078911 NP_838000.1 CDS S2639 NC_004741.1 2529298 2529798 R residues 1 to 166 of 166 are 80.72 pct identical to residues 3 to 168 of 168 from Escherichia coli K-12 : B2438; hypothetical protein complement(2529298..2529798) Shigella flexneri 2a str. 2457T 1078912 NP_838001.1 CDS S2641 NC_004741.1 2529811 2530470 R residues 1 to 219 of 219 are 97.71 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B2439; hypothetical protein complement(2529811..2530470) Shigella flexneri 2a str. 2457T 1078913 NP_838002.1 CDS S2642 NC_004741.1 2531823 2532224 D no significant similarities; hypothetical protein 2531823..2532224 Shigella flexneri 2a str. 2457T 1078914 NP_838003.1 CDS S2643 NC_004741.1 2533162 2533557 D no significant similarities; hypothetical protein 2533162..2533557 Shigella flexneri 2a str. 2457T 1078915 NP_838004.1 CDS S2644 NC_004741.1 2533575 2533838 D no significant similarities; hypothetical protein 2533575..2533838 Shigella flexneri 2a str. 2457T 1078916 NP_838005.1 CDS S2645 NC_004741.1 2533861 2534403 D no significant similarities; hypothetical protein 2533861..2534403 Shigella flexneri 2a str. 2457T 1078917 NP_838006.1 CDS S2646 NC_004741.1 2534500 2534829 D residues 44 to 105 of 109 are 36.76 pct identical to residues 14 to 81 of 81 from NRprotein_Feb2003 : >ref|NP_416939.1| orf, hypothetical protein [Escherichia coli K12] sp|P76544|YFFM_ECOLI Hypothetical protein yffM pir||C65019 hypothetical protein b2444 - Escherichia coli (strain K-12) gb|AAC75497.1| orf, hypothetical protein [Escherichia coli K12]; hypothetical protein 2534500..2534829 Shigella flexneri 2a str. 2457T 1078918 NP_838007.1 CDS S2647 NC_004741.1 2534868 2535074 D no significant similarities; hypothetical protein 2534868..2535074 Shigella flexneri 2a str. 2457T 1078919 NP_838008.1 CDS S2648 NC_004741.1 2535659 2535871 D residues 1 to 70 of 70 are 100.00 pct identical to residues 92 to 161 of 161 from GenPept : >dbj|BAA84896.1| (AB024946) orf61 [Escherichia coli]; hypothetical protein 2535659..2535871 Shigella flexneri 2a str. 2457T 1078920 NP_838009.1 CDS S2649 NC_004741.1 2536123 2537583 D residues 1 to 486 of 486 are 87.86 pct identical to residues 1 to 486 of 486 from GenPept : >dbj|BAA84897.1| (AB024946) orf62 [Escherichia coli]; amino acid antiporter 2536123..2537583 Shigella flexneri 2a str. 2457T 1078921 NP_838010.1 CDS S2650 NC_004741.1 2538545 2538940 R residues 1 to 131 of 131 are 97.70 pct identical to residues 1 to 131 of 131 from GenPept : >dbj|BAA84899.1| (AB024946) InsB [Escherichia coli]; iso-IS1 ORF2 complement(2538545..2538940) Shigella flexneri 2a str. 2457T 1078922 NP_838011.1 CDS S2651 NC_004741.1 2538967 2539239 R residues 1 to 90 of 90 are 96.66 pct identical to residues 1 to 90 of 90 from GenPept : >dbj|BAA84900.1| (AB024946) InsA [Escherichia coli]; IS1N orfA complement(2538967..2539239) Shigella flexneri 2a str. 2457T 1078923 NP_838012.1 CDS S2654 NC_004741.1 2541106 2541585 R residues 1 to 159 of 159 are 98.11 pct identical to residues 1 to 159 of 159 from Escherichia coli K-12 : B2461; hypothetical protein complement(2541106..2541585) Shigella flexneri 2a str. 2457T 1078926 NP_838013.1 CDS S2655 NC_004741.1 2541598 2542005 R residues 1 to 131 of 131 are 100.00 pct identical to residues 5 to 135 of 135 from Escherichia coli K-12 : B2462; hypothetical protein complement(2541598..2542005) Shigella flexneri 2a str. 2457T 1077682 NP_838014.1 CDS S2656 NC_004741.1 2542226 2544505 R NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme complement(2542226..2544505) Shigella flexneri 2a str. 2457T 1078927 NP_838015.1 CDS talA NC_004741.1 2544794 2545744 D Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase A 2544794..2545744 Shigella flexneri 2a str. 2457T 1078928 NP_838016.1 CDS tktB NC_004741.1 2545764 2547767 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2545764..2547767 Shigella flexneri 2a str. 2457T 1078929 NP_838017.1 CDS S2659 NC_004741.1 2547870 2548913 R residues 1 to 347 of 347 are 98.84 pct identical to residues 1 to 347 of 347 from Escherichia coli K-12 : B2466; hypothetical protein complement(2547870..2548913) Shigella flexneri 2a str. 2457T 1078930 NP_838018.1 CDS yffH NC_004741.1 2549039 2549614 R residues 1 to 191 of 191 are 97.90 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B2467; hypothetical protein complement(2549039..2549614) Shigella flexneri 2a str. 2457T 1078931 NP_838019.1 CDS yffG NC_004741.1 2549682 2551661 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit complement(2549682..2551661) Shigella flexneri 2a str. 2457T 1078932 NP_838020.1 CDS acrD NC_004741.1 2553786 2556899 D residues 1 to 1037 of 1037 are 97.01 pct identical to residues 1 to 1037 of 1037 from Escherichia coli K-12 : B2470; acriflavine resistance, integral membrane protein, possible efflux pump; aminoglycoside/multidrug efflux system 2553786..2556899 Shigella flexneri 2a str. 2457T 1078934 NP_838021.1 CDS yffB NC_004741.1 2557438 2557794 D residues 1 to 118 of 118 are 98.30 pct identical to residues 1 to 118 of 118 from Escherichia coli K-12 : B2471; hypothetical protein 2557438..2557794 Shigella flexneri 2a str. 2457T 1078935 NP_838022.1 CDS dapE NC_004741.1 2557798 2558925 D dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2557798..2558925 Shigella flexneri 2a str. 2457T 1078936 NP_838023.1 CDS ypfH NC_004741.1 2559263 2559961 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH complement(2559263..2559961) Shigella flexneri 2a str. 2457T 1078937 NP_838024.1 CDS ypfI NC_004741.1 2560035 2562050 R residues 1 to 671 of 671 are 88.07 pct identical to residues 1 to 671 of 671 from Escherichia coli K-12 : B2474; hypothetical protein complement(2560035..2562050) Shigella flexneri 2a str. 2457T 1078938 NP_838025.1 CDS S2668 NC_004741.1 2562065 2562928 R residues 1 to 287 of 287 are 89.89 pct identical to residues 1 to 287 of 287 from Escherichia coli K-12 : B2475; hypothetical protein complement(2562065..2562928) Shigella flexneri 2a str. 2457T 1078939 NP_838026.1 CDS purC NC_004741.1 2563096 2563809 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(2563096..2563809) Shigella flexneri 2a str. 2457T 1078940 NP_838027.1 CDS nlpB NC_004741.1 2564022 2565056 R residues 1 to 344 of 344 are 84.88 pct identical to residues 2 to 345 of 345 from Escherichia coli K-12 : B2477; lipoprotein complement(2564022..2565056) Shigella flexneri 2a str. 2457T 1078941 NP_838028.1 CDS dapA NC_004741.1 2565073 2565951 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(2565073..2565951) Shigella flexneri 2a str. 2457T 1078942 NP_838029.1 CDS bcp NC_004741.1 2566669 2567139 D bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2566669..2567139 Shigella flexneri 2a str. 2457T 1078944 NP_838030.1 CDS hyfA NC_004741.1 2567392 2568009 D residues 1 to 204 of 205 are 98.03 pct identical to residues 14 to 217 of 218 from Escherichia coli K-12 : B2481; hydrogenase 4 Fe-S subunit 2567392..2568009 Shigella flexneri 2a str. 2457T 1078945 NP_838031.1 CDS hyfC NC_004741.1 2570037 2570984 D residues 1 to 315 of 315 are 80.31 pct identical to residues 8 to 322 of 322 from Escherichia coli K-12 : B2483; hydrogenase 4 membrane subunit 2570037..2570984 Shigella flexneri 2a str. 2457T 1078948 NP_838032.1 CDS hyfD NC_004741.1 2571001 2572440 D residues 1 to 479 of 479 are 89.35 pct identical to residues 1 to 479 of 479 from Escherichia coli K-12 : B2484; hydrogenase 4 subunit D 2571001..2572440 Shigella flexneri 2a str. 2457T 1078949 NP_838033.1 CDS hyfE NC_004741.1 2572452 2573102 D interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2572452..2573102 Shigella flexneri 2a str. 2457T 1078950 NP_838034.1 CDS hyfF NC_004741.1 2573107 2574693 D Catalyzes the transfer of electrons from NADH to ubiquinone; hydrogenase 4 subunit F 2573107..2574693 Shigella flexneri 2a str. 2457T 1078951 NP_838035.1 CDS hyfH NC_004741.1 2576407 2576952 D probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2576407..2576952 Shigella flexneri 2a str. 2457T 1078953 NP_838036.1 CDS hyfI NC_004741.1 2576949 2577707 D residues 1 to 252 of 252 are 95.23 pct identical to residues 1 to 252 of 252 from Escherichia coli K-12 : B2489; hydrogenase 4 Fe-S subunit 2576949..2577707 Shigella flexneri 2a str. 2457T 1078954 NP_838037.1 CDS S2683 NC_004741.1 2577637 2578113 D residues 1 to 158 of 158 are 99.36 pct identical to residues 1 to 158 of 158 from Escherichia coli K-12 : B2490; protein processing element 2577637..2578113 Shigella flexneri 2a str. 2457T 1078955 NP_838038.1 CDS perM NC_004741.1 2581143 2582204 R residues 1 to 353 of 353 are 77.62 pct identical to residues 1 to 353 of 353 from Escherichia coli K-12 : B2493; permease complement(2581143..2582204) Shigella flexneri 2a str. 2457T 1078957 NP_838039.1 CDS S2687 NC_004741.1 2582417 2583880 D residues 1 to 487 of 487 are 94.86 pct identical to residues 1 to 487 of 487 from Escherichia coli K-12 : B2494; hypothetical protein 2582417..2583880 Shigella flexneri 2a str. 2457T 1078959 NP_838040.1 CDS S2688 NC_004741.1 2583901 2584260 D residues 1 to 119 of 119 are 98.31 pct identical to residues 1 to 119 of 119 from Escherichia coli K-12 : B2495; oxidoreductase 2583901..2584260 Shigella flexneri 2a str. 2457T 1078960 NP_838041.1 CDS S2689 NC_004741.1 2584393 2585139 R controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor complement(2584393..2585139) Shigella flexneri 2a str. 2457T 1078961 NP_838042.1 CDS uraA NC_004741.1 2585189 2586478 R residues 1 to 429 of 429 are 96.27 pct identical to residues 1 to 429 of 429 from Escherichia coli K-12 : B2497; uracil transporter complement(2585189..2586478) Shigella flexneri 2a str. 2457T 1078962 NP_838043.1 CDS upp NC_004741.1 2586564 2587190 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(2586564..2587190) Shigella flexneri 2a str. 2457T 1078963 NP_838044.1 CDS purM NC_004741.1 2587499 2588551 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2587499..2588551 Shigella flexneri 2a str. 2457T 1078964 NP_838045.1 CDS purN NC_004741.1 2588551 2589189 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2588551..2589189 Shigella flexneri 2a str. 2457T 1078965 NP_838046.1 CDS ppk NC_004741.1 2589361 2591427 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2589361..2591427 Shigella flexneri 2a str. 2457T 1078966 NP_838047.1 CDS ppx NC_004741.1 2591432 2592973 D residues 1 to 513 of 513 are 97.66 pct identical to residues 1 to 513 of 513 from Escherichia coli K-12 : B2502; exopolyphosphatase 2591432..2592973 Shigella flexneri 2a str. 2457T 1078967 NP_838048.1 CDS S2697 NC_004741.1 2594187 2594489 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 2594187..2594489 Shigella flexneri 2a str. 2457T 1078969 NP_838049.1 CDS S2698 NC_004741.1 2594630 2595343 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 2594630..2595343 Shigella flexneri 2a str. 2457T 1078970 NP_838050.1 CDS S2700 NC_004741.1 2596873 2597064 D residues 1 to 63 of 63 are 100.00 pct identical to residues 1 to 63 of 63 from Escherichia coli K-12 : B2504; hypothetical protein 2596873..2597064 Shigella flexneri 2a str. 2457T 1078971 NP_838051.1 CDS S2701 NC_004741.1 2597375 2597893 D residues 1 to 172 of 172 are 76.16 pct identical to residues 1 to 172 of 172 from Escherichia coli K-12 : B2505; outer membrane lipoprotein 2597375..2597893 Shigella flexneri 2a str. 2457T 1078972 NP_838052.1 CDS S2702 NC_004741.1 2597909 2598448 D residues 1 to 179 of 179 are 84.91 pct identical to residues 1 to 179 of 179 from Escherichia coli K-12 : B2506; hypothetical protein 2597909..2598448 Shigella flexneri 2a str. 2457T 1078973 NP_838053.1 CDS S2703 NC_004741.1 2598850 2599665 D residues 1 to 271 of 271 are 94.09 pct identical to residues 1 to 271 of 271 from GenPept : >gb|AAK64592.1| (AY034138) dihydropteroate synthase [Vibrio cholerae]; dihydropteroate synthase 2598850..2599665 Shigella flexneri 2a str. 2457T 1078974 NP_838054.1 CDS S2704 NC_004741.1 2599752 2600054 D residues 14 to 100 of 100 are 100.00 pct identical to residues 28 to 114 of 114 from GenPept : >dbj|BAB79612.1| (AB076707) orf7 [Salmonella enterica subsp. enterica serovar Choleraesuis]; phosphoglucosamine mutase 2599752..2600054 Shigella flexneri 2a str. 2457T 1078975 NP_838055.1 CDS S2705 NC_004741.1 2600230 2601723 R residues 1 to 497 of 497 are 100.00 pct identical to residues 1 to 497 of 497 from GenPept : >gb|AAK64580.1| (AY034138) transposase [Vibrio cholerae]; transposase complement(2600230..2601723) Shigella flexneri 2a str. 2457T 1078976 NP_838056.1 CDS S2706 NC_004741.1 2601934 2602158 R residues 3 to 69 of 74 are 56.52 pct identical to residues 2 to 70 of 71 from GenPept : >gb|AAD21670.1| (AF133830) hypothetical protein [Shuttle vector pME6030]; hypothetical protein complement(2601934..2602158) Shigella flexneri 2a str. 2457T 1078977 NP_838057.1 CDS parA NC_004741.1 2602155 2602892 R residues 12 to 216 of 245 are 67.31 pct identical to residues 15 to 219 of 219 from GenPept : >gb|AAA26414.1| (M59825) parA [Plasmid RP4]; resolvase complement(2602155..2602892) Shigella flexneri 2a str. 2457T 1078978 NP_838058.1 CDS S2708 NC_004741.1 2603040 2603372 D residues 16 to 97 of 110 are 53.57 pct identical to residues 8 to 91 of 109 from GenPept : >gb|AAK23484.1| (AE005825) transcriptional regulator, ArsR family [Caulobacter crescentus CB15]; transcriptional regulator 2603040..2603372 Shigella flexneri 2a str. 2457T 1078979 NP_838059.1 CDS S2709 NC_004741.1 2603369 2604136 D residues 13 to 250 of 255 are 66.39 pct identical to residues 5 to 243 of 244 from GenPept : >gb|AAK23485.1| (AE005825) arsenical resistance protein ArsH, [Caulobacter crescentus CB15]; arsenical resistance protein 2603369..2604136 Shigella flexneri 2a str. 2457T 1078980 NP_838060.1 CDS S2710 NC_004741.1 2604133 2604639 D residues 1 to 165 of 168 are 54.54 pct identical to residues 1 to 165 of 169 from GenPept : >dbj|BAB50737.1| (AP003003) arsenate reductase [Mesorhizobium loti]; arsenate reductase 2604133..2604639 Shigella flexneri 2a str. 2457T 1078981 NP_838061.1 CDS S2711 NC_004741.1 2604636 2605703 D residues 17 to 353 of 355 are 65.68 pct identical to residues 1 to 338 of 352 from GenPept : >gb|AAL42497.1| (AE009108) sodium bile acid symporter family protein [Agrobacterium tumefaciens str. C58 (U. Washington)]; sodium bile acid symporter family protein 2604636..2605703 Shigella flexneri 2a str. 2457T 1078982 NP_838062.1 CDS S2715 NC_004741.1 2606599 2607087 R no significant similarities; hypothetical protein complement(2606599..2607087) Shigella flexneri 2a str. 2457T 1078983 NP_838063.1 CDS trbL NC_004741.1 2607237 2608043 R residues 8 to 267 of 268 are 42.69 pct identical to residues 3 to 252 of 528 from GenPept : >gb|AAA26438.1| (M93696) trbL [Plasmid RP4]; mating pair formation protein complement(2607237..2608043) Shigella flexneri 2a str. 2457T 1078984 NP_838064.1 CDS trbJ NC_004741.1 2608282 2609061 R residues 28 to 259 of 259 are 52.58 pct identical to residues 26 to 257 of 257 from GenPept : >emb|CAD24376.1| (AJ431260) TrbJ protein [uncultured bacterium]; conjugal transfer protein TrbJ complement(2608282..2609061) Shigella flexneri 2a str. 2457T 1078985 NP_838065.1 CDS S2719 NC_004741.1 2609202 2609390 R residues 1 to 61 of 62 are 54.41 pct identical to residues 3 to 70 of 86 from GenPept : >gb|AAF84399.1|AE003987_3 (AE003987) plasmid stabilization protein [Xylella fastidiosa 9a5c]; stabilization protein complement(2609202..2609390) Shigella flexneri 2a str. 2457T 1078986 NP_838066.1 CDS repC NC_004741.1 2610423 2611304 R residues 6 to 293 of 293 are 61.35 pct identical to residues 13 to 299 of 299 from GenPept : >gb|AAA27382.1| (M73777) replication protein C [Plasmid pTF-FC2]; replication protein C complement(2610423..2611304) Shigella flexneri 2a str. 2457T 1078987 NP_838067.1 CDS S2721 NC_004741.1 2611291 2612118 R residues 3 to 275 of 275 are 81.68 pct identical to residues 7 to 279 of 279 from GenPept : >emb|CAC20104.1| (Y19120) replication protein A [Dichelobacter nodosus]; DNA helicase complement(2611291..2612118) Shigella flexneri 2a str. 2457T 1078988 NP_838068.1 CDS S2722 NC_004741.1 2612123 2612344 R no significant similarities; hypothetical protein complement(2612123..2612344) Shigella flexneri 2a str. 2457T 1078989 NP_838069.1 CDS S2723 NC_004741.1 2612492 2613694 R residues 1 to 396 of 400 are 57.43 pct identical to residues 3 to 399 of 420 from GenPept : >dbj|BAB53138.1| (AP003010) CP4-like integrase [Mesorhizobium loti]; integrase complement(2612492..2613694) Shigella flexneri 2a str. 2457T 1078990 NP_838070.1 CDS guaA NC_004741.1 2613999 2615576 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(2613999..2615576) Shigella flexneri 2a str. 2457T 1078991 NP_838071.1 CDS guaB NC_004741.1 2615645 2617111 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2615645..2617111) Shigella flexneri 2a str. 2457T 1078993 NP_838072.1 CDS xseA NC_004741.1 2617273 2618643 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2617273..2618643 Shigella flexneri 2a str. 2457T 1078994 NP_838073.1 CDS S2728 NC_004741.1 2618640 2618891 R residues 1 to 83 of 83 are 97.59 pct identical to residues 1 to 83 of 83 from Escherichia coli K-12 : B2510; hypothetical protein complement(2618640..2618891) Shigella flexneri 2a str. 2457T 1078995 NP_838074.1 CDS engA NC_004741.1 2618925 2620397 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(2618925..2620397) Shigella flexneri 2a str. 2457T 1078996 NP_838075.1 CDS S2730 NC_004741.1 2620515 2621693 R with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL complement(2620515..2621693) Shigella flexneri 2a str. 2457T 1078997 NP_838076.1 CDS S2731 NC_004741.1 2621704 2622324 R residues 1 to 206 of 206 are 91.74 pct identical to residues 1 to 206 of 206 from Escherichia coli K-12 : B2513; hypothetical protein complement(2621704..2622324) Shigella flexneri 2a str. 2457T 1078998 NP_838077.1 CDS hisS NC_004741.1 2622342 2623616 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2622342..2623616) Shigella flexneri 2a str. 2457T 1078999 NP_838078.1 CDS ispG NC_004741.1 2623719 2624846 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(2623719..2624846) Shigella flexneri 2a str. 2457T 1079000 NP_838079.1 CDS yfgA NC_004741.1 2624873 2625886 R residues 1 to 337 of 337 are 80.71 pct identical to residues 1 to 337 of 337 from Escherichia coli K-12 : B2516; hypothetical protein complement(2624873..2625886) Shigella flexneri 2a str. 2457T 1079001 NP_838080.1 CDS yfgB NC_004741.1 2626171 2627325 R residues 1 to 384 of 384 are 99.47 pct identical to residues 1 to 384 of 384 from Escherichia coli K-12 : B2517; hypothetical protein complement(2626171..2627325) Shigella flexneri 2a str. 2457T 1079002 NP_838081.1 CDS ndk NC_004741.1 2627475 2627906 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(2627475..2627906) Shigella flexneri 2a str. 2457T 1079003 NP_838082.1 CDS S2738 NC_004741.1 2630171 2631367 R residues 1 to 398 of 398 are 90.95 pct identical to residues 1 to 398 of 398 from GenPept : >gb|AAK18438.1|AF348706_127 (AF348706) transposase for IS110 [Shigella flexneri]; ISSfl4 orf complement(2630171..2631367) Shigella flexneri 2a str. 2457T 1079005 NP_838083.1 CDS sseB NC_004741.1 2632898 2633674 R enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB complement(2632898..2633674) Shigella flexneri 2a str. 2457T 1079007 NP_838084.1 CDS pepB NC_004741.1 2633816 2635099 R catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B complement(2633816..2635099) Shigella flexneri 2a str. 2457T 1079008 NP_838085.1 CDS yfhJ NC_004741.1 2635158 2635358 R residues 1 to 66 of 66 are 100.00 pct identical to residues 1 to 66 of 66 from Escherichia coli K-12 : B2524; hypothetical protein complement(2635158..2635358) Shigella flexneri 2a str. 2457T 1079010 NP_838086.1 CDS fdx NC_004741.1 2635370 2635705 R residues 1 to 111 of 111 are 100.00 pct identical to residues 1 to 111 of 111 from Escherichia coli K-12 : B2525; [2FE-2S] ferredoxin, electron carrer protein complement(2635370..2635705) Shigella flexneri 2a str. 2457T 1078311 NP_838087.1 CDS hscA NC_004741.1 2635707 2637557 R involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(2635707..2637557) Shigella flexneri 2a str. 2457T 1079011 NP_838088.1 CDS hscB NC_004741.1 2637574 2638089 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(2637574..2638089) Shigella flexneri 2a str. 2457T 1080070 NP_838089.1 CDS iscA NC_004741.1 2638185 2638508 R forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein complement(2638185..2638508) Shigella flexneri 2a str. 2457T 1079012 NP_838090.1 CDS S2748 NC_004741.1 2638525 2638911 R residues 1 to 128 of 128 are 100.00 pct identical to residues 1 to 128 of 128 from Escherichia coli K-12 : B2529; scaffold protein complement(2638525..2638911) Shigella flexneri 2a str. 2457T 1079014 NP_838091.1 CDS yfhO NC_004741.1 2638939 2640153 R catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase complement(2638939..2640153) Shigella flexneri 2a str. 2457T 1079015 NP_838092.1 CDS S2750 NC_004741.1 2640265 2640753 R regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR complement(2640265..2640753) Shigella flexneri 2a str. 2457T 1079016 NP_838093.1 CDS S2751 NC_004741.1 2641023 2641763 R residues 1 to 246 of 246 are 100.00 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B2532; ATP synthase subunit beta complement(2641023..2641763) Shigella flexneri 2a str. 2457T 1079018 NP_838094.1 CDS suhB NC_004741.1 2641882 2642685 D residues 1 to 266 of 267 are 99.62 pct identical to residues 1 to 266 of 267 from Escherichia coli K-12 : B2533; inositol monophosphatase 2641882..2642685 Shigella flexneri 2a str. 2457T 1080455 NP_838095.1 CDS S2753 NC_004741.1 2642830 2643684 D residues 1 to 284 of 284 are 98.59 pct identical to residues 10 to 293 of 293 from Escherichia coli K-12 : B2534; enzyme 2642830..2643684 Shigella flexneri 2a str. 2457T 1079019 NP_838096.1 CDS csiE NC_004741.1 2643875 2645155 D residues 1 to 426 of 426 are 96.47 pct identical to residues 8 to 433 of 433 from Escherichia coli K-12 : B2535; stationary phase inducible protein CsiE 2643875..2645155 Shigella flexneri 2a str. 2457T 1079020 NP_838097.1 CDS hcaT NC_004741.1 2645147 2646286 R transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter complement(2645147..2646286) Shigella flexneri 2a str. 2457T 1078286 NP_838098.1 CDS hcaR NC_004741.1 2646446 2647336 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR complement(2646446..2647336) Shigella flexneri 2a str. 2457T 1079021 NP_838099.1 CDS hcaA1 NC_004741.1 2647472 2648833 D residues 1 to 453 of 453 are 99.55 pct identical to residues 1 to 453 of 453 from Escherichia coli K-12 : B2538; large terminal subunit of phenylpropionate dioxygenase 2647472..2648833 Shigella flexneri 2a str. 2457T 1078029 NP_838100.1 CDS hcaA2 NC_004741.1 2648830 2649348 D residues 1 to 172 of 172 are 99.41 pct identical to residues 1 to 172 of 172 from Escherichia coli K-12 : B2539; 3-phenylpropionate dioxygenase subunit beta 2648830..2649348 Shigella flexneri 2a str. 2457T 1079025 NP_838101.1 CDS hcaC NC_004741.1 2649348 2649668 D residues 1 to 106 of 106 are 100.00 pct identical to residues 1 to 106 of 106 from Escherichia coli K-12 : B2540; 3-phenylpropionate dioxygenase ferredoxin subunit 2649348..2649668 Shigella flexneri 2a str. 2457T 1079026 NP_838102.1 CDS hcaB NC_004741.1 2649665 2650477 D Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2649665..2650477 Shigella flexneri 2a str. 2457T 1079027 NP_838103.1 CDS yphA NC_004741.1 2651734 2652228 D residues 1 to 164 of 164 are 89.63 pct identical to residues 1 to 164 of 164 from Escherichia coli K-12 : B2543; hypothetical protein 2651734..2652228 Shigella flexneri 2a str. 2457T 1079028 NP_838104.1 CDS yphB NC_004741.1 2652276 2653148 R residues 1 to 290 of 290 are 99.31 pct identical to residues 1 to 290 of 290 from Escherichia coli K-12 : B2544; hypothetical protein complement(2652276..2653148) Shigella flexneri 2a str. 2457T 1079029 NP_838105.1 CDS yphC NC_004741.1 2653160 2654254 R residues 1 to 364 of 364 are 94.23 pct identical to residues 1 to 364 of 364 from Escherichia coli K-12 : B2545; oxidoreductase complement(2653160..2654254) Shigella flexneri 2a str. 2457T 1078221 NP_838106.1 CDS yphD NC_004741.1 2654287 2655285 R residues 1 to 332 of 332 are 75.30 pct identical to residues 1 to 332 of 332 from Escherichia coli K-12 : B2546; transport system permease complement(2654287..2655285) Shigella flexneri 2a str. 2457T 1079031 NP_838107.1 CDS yphE NC_004741.1 2655310 2656821 R residues 1 to 503 of 503 are 99.00 pct identical to residues 1 to 503 of 503 from Escherichia coli K-12 : B2547; ATP-binding component of a transport system complement(2655310..2656821) Shigella flexneri 2a str. 2457T 1079032 NP_838108.1 CDS yphH NC_004741.1 2661322 2662515 D residues 1 to 397 of 397 are 98.48 pct identical to residues 3 to 399 of 399 from Escherichia coli K-12 : B2550; NAGC-like transcriptional regulator 2661322..2662515 Shigella flexneri 2a str. 2457T 1079034 NP_838109.1 CDS glyA NC_004741.1 2662713 2663966 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(2662713..2663966) Shigella flexneri 2a str. 2457T 1079037 NP_838110.1 CDS hmpA NC_004741.1 2664293 2665483 D flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2664293..2665483 Shigella flexneri 2a str. 2457T 1079038 NP_838111.1 CDS glnB NC_004741.1 2665528 2665866 R indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 complement(2665528..2665866) Shigella flexneri 2a str. 2457T 1079039 NP_838112.1 CDS yfhA NC_004741.1 2665927 2667261 R residues 1 to 444 of 444 are 95.49 pct identical to residues 1 to 444 of 444 from Escherichia coli K-12 : B2554; 2-component transcriptional regulator complement(2665927..2667261) Shigella flexneri 2a str. 2457T 1076483 NP_838113.1 CDS yfhG NC_004741.1 2667251 2667964 R residues 1 to 237 of 237 are 84.38 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B2555; hypothetical protein complement(2667251..2667964) Shigella flexneri 2a str. 2457T 1079041 NP_838114.1 CDS yfhK NC_004741.1 2668129 2669619 R residues 1 to 488 of 488 are 87.90 pct identical to residues 9 to 496 of 496 from Escherichia coli K-12 : B2556; 2-component sensor protein complement(2668129..2669619) Shigella flexneri 2a str. 2457T 1079042 NP_838115.1 CDS purL NC_004741.1 2670114 2674001 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(2670114..2674001) Shigella flexneri 2a str. 2457T 1079043 NP_838116.1 CDS yfhD NC_004741.1 2674398 2675816 D YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 2674398..2675816 Shigella flexneri 2a str. 2457T 1079044 NP_838117.1 CDS yfhC NC_004741.1 2675813 2676349 R residues 1 to 178 of 178 are 100.00 pct identical to residues 1 to 178 of 178 from Escherichia coli K-12 : B2559; tRNA-specific adenosine deaminase complement(2675813..2676349) Shigella flexneri 2a str. 2457T 1079045 NP_838118.2 CDS yfhB NC_004741.1 2676374 2677009 R residues 1 to 190 of 190 are 89.47 pct identical to residues 1 to 190 of 190 from Escherichia coli K-12 : B2560; hypothetical protein complement(2676374..2677009) Shigella flexneri 2a str. 2457T 1079046 NP_838119.2 CDS yfhH NC_004741.1 2677218 2678066 D residues 1 to 306 of 306 are 95.75 pct identical to residues 1 to 306 of 306 from Escherichia coli K-12 : B2561; DNA-binding transcriptional regulator 2677218..2678066 Shigella flexneri 2a str. 2457T 1079048 NP_838120.1 CDS S2781 NC_004741.1 2678519 2678959 R residues 1 to 146 of 146 are 89.72 pct identical to residues 1 to 146 of 184 from GenPept : >gb|AAC74242.1| (AE000214) inversion of adjacent DNA; at locus of e14 element [Escherichia coli K12]; DNA-invertase complement(2678519..2678959) Shigella flexneri 2a str. 2457T 1079050 NP_838121.1 CDS ipaH_7 NC_004741.1 2679457 2681283 D residues 1 to 608 of 608 are 63.54 pct identical to residues 1 to 565 of 565 from NRprotein_Feb03 : >ref|NP_085238.1| invasion plasmid antigen [Shigella flexneri] emb|CAC05787.1| IpaH7.8, member of the IpaH family, secreted by the Mxi-Spa secretion machinery, function unknown [Shigella flexneri]; invasion plasmid antigen 2679457..2681283 Shigella flexneri 2a str. 2457T 1079051 NP_838122.1 CDS S2783 NC_004741.1 2681284 2681829 R residues 5 to 146 of 181 are 60.56 pct identical to residues 24 to 165 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein complement(2681284..2681829) Shigella flexneri 2a str. 2457T 1079052 NP_838123.1 CDS S2784 NC_004741.1 2681874 2683163 R residues 1 to 420 of 429 are 36.74 pct identical to residues 1 to 488 of 490 from GenPept : >emb|CAC83574.1| (AJ298298) tail fiber protein [Bacteriophage P27]; tail fiber protein complement(2681874..2683163) Shigella flexneri 2a str. 2457T 1079053 NP_838124.1 CDS S2785 NC_004741.1 2683187 2683675 R residues 9 to 162 of 162 are 75.97 pct identical to residues 29 to 182 of 182 from GenPept : >emb|CAC83573.1| (AJ298298) tail fiber assembly protein [Bacteriophage P27]; tail fiber assembly protein complement(2683187..2683675) Shigella flexneri 2a str. 2457T 1079054 NP_838125.1 CDS S2786 NC_004741.1 2683735 2683845 R residues 3 to 36 of 36 are 76.47 pct identical to residues 525 to 558 of 558 from GenPept : >dbj|BAA00552.1| (D00660) Bcv gene product [Shigella boydii]; tail fiber protein complement(2683735..2683845) Shigella flexneri 2a str. 2457T 1079056 NP_838126.2 CDS S2787 NC_004741.1 2684317 2684682 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2684317..2684682 Shigella flexneri 2a str. 2457T 1079057 NP_838127.2 CDS S2788 NC_004741.1 2684640 2685545 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2684640..2685545 Shigella flexneri 2a str. 2457T 1079938 NP_838128.1 CDS S2789 NC_004741.1 2685470 2686456 R residues 145 to 301 of 328 are 80.89 pct identical to residues 86 to 242 of 332 from GenPept : >emb|CAC83572.1| (AJ298298) tail fiber protein [Bacteriophage P27]; tail fiber protein complement(2685470..2686456) Shigella flexneri 2a str. 2457T 1079058 NP_838129.1 CDS S2790 NC_004741.1 2686443 2687048 R no significant similarities; hypothetical protein complement(2686443..2687048) Shigella flexneri 2a str. 2457T 1079059 NP_838130.1 CDS S2791 NC_004741.1 2687050 2687517 R no significant similarities; bacteriophage protein complement(2687050..2687517) Shigella flexneri 2a str. 2457T 1079060 NP_838131.1 CDS S2793 NC_004741.1 2687812 2688114 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 2687812..2688114 Shigella flexneri 2a str. 2457T 1079061 NP_838132.1 CDS S2794 NC_004741.1 2688255 2688968 D residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 2688255..2688968 Shigella flexneri 2a str. 2457T 1079062 NP_838133.1 CDS S2795 NC_004741.1 2689009 2689665 R no significant similarities; hypothetical protein complement(2689009..2689665) Shigella flexneri 2a str. 2457T 1079063 NP_838134.1 CDS S2796 NC_004741.1 2689707 2690108 R no significant similarities; hypothetical protein complement(2689707..2690108) Shigella flexneri 2a str. 2457T 1079064 NP_838135.1 CDS yfhL NC_004741.1 2690323 2690583 D residues 1 to 86 of 86 are 97.67 pct identical to residues 1 to 86 of 86 from Escherichia coli K-12 : B2562; hypothetical protein 2690323..2690583 Shigella flexneri 2a str. 2457T 1079937 NP_838136.1 CDS acpS NC_004741.1 2691277 2691657 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(2691277..2691657) Shigella flexneri 2a str. 2457T 1079065 NP_838137.1 CDS pdxJ NC_004741.1 2691657 2692388 R involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase complement(2691657..2692388) Shigella flexneri 2a str. 2457T 1079066 NP_838138.1 CDS recO NC_004741.1 2692400 2693128 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(2692400..2693128) Shigella flexneri 2a str. 2457T 1079067 NP_838139.1 CDS era NC_004741.1 2693140 2694045 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(2693140..2694045) Shigella flexneri 2a str. 2457T 1079068 NP_838140.1 CDS rnc NC_004741.1 2694042 2694722 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(2694042..2694722) Shigella flexneri 2a str. 2457T 1080503 NP_838141.1 CDS lepB NC_004741.1 2694994 2695968 R catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I complement(2694994..2695968) Shigella flexneri 2a str. 2457T 1079069 NP_838142.1 CDS lepA NC_004741.1 2695984 2697783 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(2695984..2697783) Shigella flexneri 2a str. 2457T 1079070 NP_838143.1 CDS rseC NC_004741.1 2697981 2698460 R involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC complement(2697981..2698460) Shigella flexneri 2a str. 2457T 1079071 NP_838144.1 CDS rseB NC_004741.1 2698457 2699413 R periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE complement(2698457..2699413) Shigella flexneri 2a str. 2457T 1079072 NP_838145.1 CDS rseA NC_004741.1 2699413 2700063 R residues 1 to 216 of 216 are 87.50 pct identical to residues 1 to 216 of 216 from Escherichia coli K-12 : B2572; anti-RNA polymerase sigma factor SigE complement(2699413..2700063) Shigella flexneri 2a str. 2457T 1078127 NP_838146.1 CDS rpoE NC_004741.1 2700096 2700671 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(2700096..2700671) Shigella flexneri 2a str. 2457T 1079073 NP_838147.1 CDS yfiC NC_004741.1 2702686 2703543 R residues 1 to 285 of 285 are 89.82 pct identical to residues 1 to 285 of 285 from Escherichia coli K-12 : B2575; enzyme complement(2702686..2703543) Shigella flexneri 2a str. 2457T 1079075 NP_838148.1 CDS srmB NC_004741.1 2703555 2704889 D facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2703555..2704889 Shigella flexneri 2a str. 2457T 1079076 NP_838149.1 CDS yfiE NC_004741.1 2704924 2705850 R residues 1 to 306 of 308 are 97.05 pct identical to residues 1 to 306 of 308 from Escherichia coli K-12 : B2577; LYSR-type transcriptional regulator complement(2704924..2705850) Shigella flexneri 2a str. 2457T 1079077 NP_838150.1 CDS yfiK NC_004741.1 2705908 2706495 D residues 1 to 195 of 195 are 99.48 pct identical to residues 1 to 195 of 195 from Escherichia coli K-12 : B2578; neutral amino-acid efflux protein 2705908..2706495 Shigella flexneri 2a str. 2457T 1078810 NP_838151.1 CDS yfiD NC_004741.1 2706551 2706934 R stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA complement(2706551..2706934) Shigella flexneri 2a str. 2457T 1079078 NP_838152.1 CDS ung NC_004741.1 2707239 2707928 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2707239..2707928 Shigella flexneri 2a str. 2457T 1079079 NP_838153.1 CDS yfiF NC_004741.1 2707976 2709013 R residues 1 to 345 of 345 are 92.75 pct identical to residues 1 to 345 of 345 from Escherichia coli K-12 : B2581; methyltransferase complement(2707976..2709013) Shigella flexneri 2a str. 2457T 1079080 NP_838154.1 CDS trxC NC_004741.1 2709220 2709639 D residues 1 to 139 of 139 are 93.52 pct identical to residues 1 to 139 of 139 from Escherichia coli K-12 : B2582; thioredoxin 2 2709220..2709639 Shigella flexneri 2a str. 2457T 1079081 NP_838155.1 CDS yfiP NC_004741.1 2709684 2710406 D residues 1 to 240 of 240 are 99.16 pct identical to residues 1 to 240 of 240 from Escherichia coli K-12 : B2583; hypothetical protein 2709684..2710406 Shigella flexneri 2a str. 2457T 1079082 NP_838156.1 CDS yfiQ NC_004741.1 2710438 2713098 D residues 1 to 886 of 886 are 95.59 pct identical to residues 1 to 886 of 886 from Escherichia coli K-12 : B2584; hypothetical protein 2710438..2713098 Shigella flexneri 2a str. 2457T 1079083 NP_838157.1 CDS pssA NC_004741.1 2713212 2714567 D catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2713212..2714567 Shigella flexneri 2a str. 2457T 1079084 NP_838158.1 CDS yfiM NC_004741.1 2714664 2714936 D residues 1 to 90 of 90 are 97.77 pct identical to residues 1 to 90 of 90 from Escherichia coli K-12 : B2586; hypothetical protein 2714664..2714936 Shigella flexneri 2a str. 2457T 1079085 NP_838159.1 CDS kgtP NC_004741.1 2714933 2716231 R residues 1 to 432 of 432 are 92.36 pct identical to residues 1 to 432 of 432 from Escherichia coli K-12 : B2587; alpha-ketoglutarate transporter complement(2714933..2716231) Shigella flexneri 2a str. 2457T 1079086 NP_838160.1 CDS S2827 NC_004741.1 2722081 2723409 D residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 2722081..2723409 Shigella flexneri 2a str. 2457T 1079091 NP_838161.1 CDS S2828 NC_004741.1 2723460 2724197 R with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO complement(2723460..2724197) Shigella flexneri 2a str. 2457T 1079092 NP_838162.1 CDS rluD NC_004741.1 2724332 2725312 D responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 2724332..2725312 Shigella flexneri 2a str. 2457T 1079093 NP_838163.1 CDS yfiH NC_004741.1 2725309 2726040 D residues 1 to 243 of 243 are 98.35 pct identical to residues 1 to 243 of 243 from Escherichia coli K-12 : B2593; hypothetical protein 2725309..2726040 Shigella flexneri 2a str. 2457T 1079094 NP_838164.1 CDS clpB NC_004741.1 2726170 2728743 D residues 1 to 857 of 857 are 95.44 pct identical to residues 1 to 857 of 857 from Escherichia coli K-12 : B2592; protein disaggregation chaperone 2726170..2728743 Shigella flexneri 2a str. 2457T 1079095 NP_838165.1 CDS S2832 NC_004741.1 2728780 2729790 R residues 1 to 336 of 336 are 99.40 pct identical to residues 113 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; partial; IS4 orf complement(2728780..2729790) Shigella flexneri 2a str. 2457T 1079096 NP_838166.1 CDS S2833 NC_004741.1 2729727 2730107 R residues 1 to 126 of 126 are 100.00 pct identical to residues 7 to 132 of 132 from GenPept : >gb|AAL72522.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS4 orf complement(2729727..2730107) Shigella flexneri 2a str. 2457T 1079097 NP_838167.1 CDS S2834 NC_004741.1 2730198 2730404 D residues 1 to 68 of 68 are 94.11 pct identical to residues 1 to 68 of 68 from Escherichia coli K-12 : B2596; hypothetical protein 2730198..2730404 Shigella flexneri 2a str. 2457T 1079098 NP_838168.1 CDS yfiA NC_004741.1 2730439 2730780 D associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2730439..2730780 Shigella flexneri 2a str. 2457T 1079099 NP_838170.1 CDS pheA NC_004741.1 2731030 2732190 D catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2731030..2732190 Shigella flexneri 2a str. 2457T 1079101 NP_838171.1 CDS tyrA NC_004741.1 2732233 2733354 R catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase complement(2732233..2733354) Shigella flexneri 2a str. 2457T 1079102 NP_838172.1 CDS aroF NC_004741.1 2733365 2734435 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(2733365..2734435) Shigella flexneri 2a str. 2457T 1079103 NP_838173.1 CDS yfiL NC_004741.1 2734645 2735010 D residues 1 to 121 of 121 are 99.17 pct identical to residues 14 to 134 of 134 from Escherichia coli K-12 : B2602; hypothetical protein 2734645..2735010 Shigella flexneri 2a str. 2457T 1079104 NP_838174.1 CDS S2840 NC_004741.1 2735160 2735678 D residues 1 to 172 of 172 are 94.18 pct identical to residues 1 to 172 of 172 from Escherichia coli K-12 : B2603; hypothetical protein 2735160..2735678 Shigella flexneri 2a str. 2457T 1079105 NP_838175.1 CDS yfiB NC_004741.1 2736909 2737391 D residues 1 to 160 of 160 are 98.75 pct identical to residues 1 to 160 of 160 from Escherichia coli K-12 : B2605; outer membrane lipoprotein 2736909..2737391 Shigella flexneri 2a str. 2457T 1079107 NP_838176.1 CDS rplS NC_004741.1 2737468 2737815 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(2737468..2737815) Shigella flexneri 2a str. 2457T 1079108 NP_838177.1 CDS trmD NC_004741.1 2737857 2738624 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(2737857..2738624) Shigella flexneri 2a str. 2457T 1079109 NP_838178.1 CDS rimM NC_004741.1 2738655 2739203 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(2738655..2739203) Shigella flexneri 2a str. 2457T 1079110 NP_838179.1 CDS rpsP NC_004741.1 2739222 2739470 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(2739222..2739470) Shigella flexneri 2a str. 2457T 1079111 NP_838180.1 CDS ffh NC_004741.1 2739607 2740968 R with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein complement(2739607..2740968) Shigella flexneri 2a str. 2457T 1079112 NP_838181.1 CDS S2848 NC_004741.1 2741060 2741926 D residues 1 to 288 of 288 are 79.16 pct identical to residues 1 to 288 of 288 from Escherichia coli K-12 : B2611; hypothetical protein 2741060..2741926 Shigella flexneri 2a str. 2457T 1079113 NP_838182.1 CDS yfjD NC_004741.1 2742550 2743233 D residues 1 to 227 of 227 are 99.55 pct identical to residues 1 to 227 of 227 from Escherichia coli K-12 : B2613; transporter 2742550..2743233 Shigella flexneri 2a str. 2457T 1079115 NP_838183.1 CDS grpE NC_004741.1 2743288 2743881 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(2743288..2743881) Shigella flexneri 2a str. 2457T 1079116 NP_838184.1 CDS ppnK NC_004741.1 2744004 2744882 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2744004..2744882 Shigella flexneri 2a str. 2457T 1079117 NP_838185.1 CDS recN NC_004741.1 2744968 2746629 D residues 1 to 553 of 553 are 95.47 pct identical to residues 1 to 553 of 553 from Escherichia coli K-12 : B2616; recombination and repair protein 2744968..2746629 Shigella flexneri 2a str. 2457T 1079118 NP_838186.1 CDS smpA NC_004741.1 2746967 2747119 D residues 1 to 50 of 50 are 100.00 pct identical to residues 1 to 50 of 50 from Escherichia coli K-12 : B2617; small membrane protein A 2746967..2747119 Shigella flexneri 2a str. 2457T 1079119 NP_838187.1 CDS S2855 NC_004741.1 2747181 2747471 R residues 3 to 96 of 96 are 100.00 pct identical to residues 9 to 102 of 102 from Escherichia coli K-12 : B2618; hypothetical protein complement(2747181..2747471) Shigella flexneri 2a str. 2457T 1079120 NP_838188.1 CDS S2856 NC_004741.1 2747461 2747898 R residues 1 to 145 of 145 are 100.00 pct identical to residues 14 to 158 of 158 from Escherichia coli K-12 : B2619; hypothetical protein complement(2747461..2747898) Shigella flexneri 2a str. 2457T 1079121 NP_838189.1 CDS smpB NC_004741.1 2748069 2748551 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2748069..2748551 Shigella flexneri 2a str. 2457T 1079122 NP_838190.1 CDS S2859 NC_004741.1 2749333 2750574 D CP4-57 prophage; integrase; integrase 2749333..2750574 Shigella flexneri 2a str. 2457T 1079124 NP_838191.1 CDS S2860 NC_004741.1 2750774 2751073 D residues 1 to 90 of 99 are 98.88 pct identical to residues 1 to 90 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2750774..2751073 Shigella flexneri 2a str. 2457T 1079125 NP_838192.1 CDS S2861 NC_004741.1 2751589 2751888 D residues 1 to 99 of 99 are 100.00 pct identical to residues 1 to 99 of 99 from GenPept : >gb|AAL57580.1|AF453442_9 (AF453442) transposase 2 [Escherichia coli]; IS3 orfA 2751589..2751888 Shigella flexneri 2a str. 2457T 1079126 NP_838193.1 CDS S2862 NC_004741.1 2751885 2752313 D residues 1 to 133 of 142 are 94.73 pct identical to residues 1 to 133 of 288 from GenPept : >gb|AAL57581.1|AF453442_10 (AF453442) transposase 1 [Escherichia coli]; partial; IS3 orfB 2751885..2752313 Shigella flexneri 2a str. 2457T 1079127 NP_838194.1 CDS S2863 NC_004741.1 2752333 2752440 D residues 1 to 22 of 36 are 100 pct identical to residues 167 to 188 of 305 from GenPept : >gb|CAB37974.1|X02311 (AF453442) hypothetical protein of IS3 [Escherichia coli]; partial; IS3 orfB 2752333..2752440 Shigella flexneri 2a str. 2457T 1079128 NP_838196.1 CDS S2870 NC_004741.1 2755617 2755889 D residues 1 to 90 of 90 are 96.66 pct identical to residues 1 to 90 of 90 from Escherichia coli K-12 : B2658; hypothetical protein 2755617..2755889 Shigella flexneri 2a str. 2457T 1079135 NP_838197.2 CDS S2871 NC_004741.1 2756225 2757157 D in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2756225..2757157 Shigella flexneri 2a str. 2457T 1079136 NP_838198.1 CDS ygaF NC_004741.1 2757111 2758445 D catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 2757111..2758445 Shigella flexneri 2a str. 2457T 1079137 NP_838199.1 CDS gabT NC_004741.1 2760083 2761210 D catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2760083..2761210 Shigella flexneri 2a str. 2457T 1079139 NP_838200.1 CDS gabP NC_004741.1 2761448 2762848 D residues 1 to 466 of 466 are 99.35 pct identical to residues 1 to 466 of 466 from Escherichia coli K-12 : B2663; gamma-aminobutyrate transporter 2761448..2762848 Shigella flexneri 2a str. 2457T 1079140 NP_838201.1 CDS ygaE NC_004741.1 2762869 2763531 D regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2762869..2763531 Shigella flexneri 2a str. 2457T 1079141 NP_838202.1 CDS ygaU NC_004741.1 2763532 2763981 R residues 1 to 149 of 149 are 99.32 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B2665; LysM domain/BON superfamily protein complement(2763532..2763981) Shigella flexneri 2a str. 2457T 1079142 NP_838203.1 CDS S2878 NC_004741.1 2764065 2764223 R residues 1 to 52 of 52 are 98.07 pct identical to residues 1 to 52 of 52 from Escherichia coli K-12 : B2666; hypothetical protein complement(2764065..2764223) Shigella flexneri 2a str. 2457T 1079143 NP_838204.2 CDS S2879 NC_004741.1 2764324 2765229 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(2764324..2765229) Shigella flexneri 2a str. 2457T 1079144 NP_838205.2 CDS S2880 NC_004741.1 2765187 2765552 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(2765187..2765552) Shigella flexneri 2a str. 2457T 1079145 NP_838206.1 CDS S2881 NC_004741.1 2765742 2766041 D residues 1 to 99 of 99 are 97.97 pct identical to residues 1 to 99 of 99 from Escherichia coli K-12 : B2667; hypothetical protein 2765742..2766041 Shigella flexneri 2a str. 2457T 1079146 NP_838207.1 CDS ygaP NC_004741.1 2766051 2766575 D residues 1 to 174 of 174 are 97.70 pct identical to residues 1 to 174 of 174 from Escherichia coli K-12 : B2668; hypothetical protein 2766051..2766575 Shigella flexneri 2a str. 2457T 1079147 NP_838208.1 CDS stpA NC_004741.1 2766622 2767026 R residues 1 to 134 of 134 are 86.56 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B2669; DNA binding protein, nucleoid-associated complement(2766622..2767026) Shigella flexneri 2a str. 2457T 1079148 NP_838209.1 CDS S2884 NC_004741.1 2767694 2768143 D residues 1 to 149 of 149 are 100.00 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B2670; hypothetical protein 2767694..2768143 Shigella flexneri 2a str. 2457T 1079149 NP_838210.1 CDS ygaC NC_004741.1 2768180 2768524 R residues 1 to 114 of 114 are 100.00 pct identical to residues 1 to 114 of 114 from Escherichia coli K-12 : B2671; hypothetical protein complement(2768180..2768524) Shigella flexneri 2a str. 2457T 1079150 NP_838211.1 CDS nrdH NC_004741.1 2769253 2769498 D residues 1 to 81 of 81 are 100.00 pct identical to residues 1 to 81 of 81 from Escherichia coli K-12 : B2673; hydrogen donor; glutaredoxin-like protein 2769253..2769498 Shigella flexneri 2a str. 2457T 1079152 NP_838212.1 CDS nrdI NC_004741.1 2769495 2769905 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2769495..2769905 Shigella flexneri 2a str. 2457T 1079153 NP_838213.1 CDS nrdE NC_004741.1 2769917 2772022 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2769917..2772022 Shigella flexneri 2a str. 2457T 1079154 NP_838214.1 CDS nrdF NC_004741.1 2772032 2772991 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2772032..2772991 Shigella flexneri 2a str. 2457T 1079155 NP_838215.1 CDS proV NC_004741.1 2773346 2774548 D with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 2773346..2774548 Shigella flexneri 2a str. 2457T 1079156 NP_838216.1 CDS proW NC_004741.1 2774541 2775605 D with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2774541..2775605 Shigella flexneri 2a str. 2457T 1079157 NP_838217.1 CDS proX NC_004741.1 2775663 2776655 D with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 2775663..2776655 Shigella flexneri 2a str. 2457T 1079158 NP_838218.1 CDS S2894 NC_004741.1 2776847 2777806 D residues 1 to 87 of 310 are 100.00 pct identical to residues 1 to 87 of 88 from Escherichia coli K-12 : B2680; hypothetical protein 2776847..2777806 Shigella flexneri 2a str. 2457T 1079160 NP_838219.1 CDS S2896 NC_004741.1 2778150 2778887 D residues 1 to 245 of 245 are 93.46 pct identical to residues 1 to 245 of 245 from Escherichia coli K-12 : B2682; hypothetical protein 2778150..2778887 Shigella flexneri 2a str. 2457T 1079161 NP_838220.1 CDS ygaH NC_004741.1 2778877 2779212 D residues 1 to 111 of 111 are 90.09 pct identical to residues 1 to 111 of 111 from Escherichia coli K-12 : B2683; hypothetical protein 2778877..2779212 Shigella flexneri 2a str. 2457T 1079162 NP_838221.1 CDS emrR NC_004741.1 2779303 2779833 D DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2779303..2779833 Shigella flexneri 2a str. 2457T 1079163 NP_838222.1 CDS emrB NC_004741.1 2781149 2782687 D residues 1 to 512 of 512 are 91.99 pct identical to residues 1 to 512 of 512 from Escherichia coli K-12 : B2686; multidrug resistant protein emrB 2781149..2782687 Shigella flexneri 2a str. 2457T 1079165 NP_838223.1 CDS ygaG NC_004741.1 2782751 2783266 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(2782751..2783266) Shigella flexneri 2a str. 2457T 1079166 NP_838224.1 CDS gshA NC_004741.1 2783416 2784972 R involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase complement(2783416..2784972) Shigella flexneri 2a str. 2457T 1079167 NP_838225.1 CDS S2903 NC_004741.1 2785045 2785473 R residues 22 to 142 of 142 are 100.00 pct identical to residues 22 to 142 of 142 from Escherichia coli K-12 : B2689; hypothetical protein complement(2785045..2785473) Shigella flexneri 2a str. 2457T 1079168 NP_838226.1 CDS yqaB NC_004741.1 2785470 2786036 R YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase complement(2785470..2786036) Shigella flexneri 2a str. 2457T 1079169 NP_838227.1 CDS csrA NC_004741.1 2787095 2787280 R affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator complement(2787095..2787280) Shigella flexneri 2a str. 2457T 1079175 NP_838228.1 CDS alaS NC_004741.1 2787515 2790145 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(2787515..2790145) Shigella flexneri 2a str. 2457T 1079176 NP_838229.1 CDS recX NC_004741.1 2790273 2790773 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(2790273..2790773) Shigella flexneri 2a str. 2457T 1079177 NP_838230.1 CDS recA NC_004741.1 2791016 2792077 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(2791016..2792077) Shigella flexneri 2a str. 2457T 1079178 NP_838231.1 CDS ygaD NC_004741.1 2792157 2792654 R residues 1 to 165 of 165 are 100.00 pct identical to residues 1 to 165 of 165 from Escherichia coli K-12 : B2700; competence damage-inducible protein A complement(2792157..2792654) Shigella flexneri 2a str. 2457T 1079179 NP_838232.1 CDS mltB NC_004741.1 2792799 2793884 R membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B complement(2792799..2793884) Shigella flexneri 2a str. 2457T 1079180 NP_838233.1 CDS srlE NC_004741.1 2794700 2795659 D residues 1 to 319 of 319 are 92.47 pct identical to residues 1 to 319 of 319 from Escherichia coli K-12 : B2703; PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components 2794700..2795659 Shigella flexneri 2a str. 2457T 1079182 NP_838234.1 CDS srlB NC_004741.1 2795670 2796041 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; glucitol/sorbitol-specific PTS system component IIA 2795670..2796041 Shigella flexneri 2a str. 2457T 1079183 NP_838235.1 CDS srlD NC_004741.1 2796045 2796824 D catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2796045..2796824 Shigella flexneri 2a str. 2457T 1079184 NP_838236.1 CDS gutM NC_004741.1 2796929 2797288 D regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2796929..2797288 Shigella flexneri 2a str. 2457T 1079185 NP_838237.1 CDS srlR NC_004741.1 2797355 2798128 D regulates genes involved in glucitol utilization; DNA-bindng transcriptional repressor SrlR 2797355..2798128 Shigella flexneri 2a str. 2457T 1079186 NP_838238.2 CDS gutQ NC_004741.1 2798121 2799086 D catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 2798121..2799086 Shigella flexneri 2a str. 2457T 1079187 NP_838239.2 CDS ygaA NC_004741.1 2799083 2800597 R Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcriptional regulator complement(2799083..2800597) Shigella flexneri 2a str. 2457T 1079188 NP_838240.1 CDS S2924 NC_004741.1 2800784 2802223 D detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 2800784..2802223 Shigella flexneri 2a str. 2457T 1079189 NP_838241.1 CDS ygbD NC_004741.1 2802220 2803353 D catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 2802220..2803353 Shigella flexneri 2a str. 2457T 1079190 NP_838242.1 CDS hypF NC_004741.1 2803481 2805733 R residues 1 to 750 of 750 are 89.73 pct identical to residues 1 to 750 of 750 from Escherichia coli K-12 : B2712; transcriptional regulatory protein complement(2803481..2805733) Shigella flexneri 2a str. 2457T 1079191 NP_838243.1 CDS hydN NC_004741.1 2805886 2806413 R involved in electron transport from formate to hydrogen; electron transport protein HydN complement(2805886..2806413) Shigella flexneri 2a str. 2457T 1079192 NP_838244.1 CDS ascG NC_004741.1 2806562 2807572 R residues 1 to 336 of 336 are 97.91 pct identical to residues 2 to 337 of 337 from Escherichia coli K-12 : B2714; ascBF operon repressor complement(2806562..2807572) Shigella flexneri 2a str. 2457T 1079193 NP_838245.1 CDS hycF NC_004741.1 2807586 2807705 R residues 1 to 38 of 39 are 62.79 pct identical to residues 1 to 43 of 180 from Escherichia coli K-12 : B2720; iron-sulfur protein of hydrogenase 3 (part of FHL complex) complement(2807586..2807705) Shigella flexneri 2a str. 2457T 1079194 NP_838246.1 CDS hycE NC_004741.1 2807715 2809424 R residues 1 to 569 of 569 are 96.83 pct identical to residues 1 to 569 of 569 from Escherichia coli K-12 : B2721; large subunit of hydrogenase 3 (part of FHL complex) complement(2807715..2809424) Shigella flexneri 2a str. 2457T 1079195 NP_838247.1 CDS hycD NC_004741.1 2809442 2810365 R residues 1 to 291 of 307 are 91.40 pct identical to residues 1 to 291 of 307 from Escherichia coli K-12 : B2722; membrane-spanning protein of hydrogenase 3 (part of FHL complex) complement(2809442..2810365) Shigella flexneri 2a str. 2457T 1079196 NP_838248.1 CDS hycC NC_004741.1 2810368 2812161 R catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 complement(2810368..2812161) Shigella flexneri 2a str. 2457T 1079197 NP_838249.1 CDS hycB NC_004741.1 2812198 2812809 R residues 1 to 203 of 203 are 91.62 pct identical to residues 1 to 203 of 203 from Escherichia coli K-12 : B2724; small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) complement(2812198..2812809) Shigella flexneri 2a str. 2457T 1079198 NP_838250.1 CDS hycA NC_004741.1 2812934 2813395 R regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA complement(2812934..2813395) Shigella flexneri 2a str. 2457T 1079199 NP_838251.1 CDS hypA NC_004741.1 2813595 2813957 D plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 2813595..2813957 Shigella flexneri 2a str. 2457T 1079200 NP_838252.1 CDS hypB NC_004741.1 2813961 2814833 D GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 2813961..2814833 Shigella flexneri 2a str. 2457T 1079201 NP_838253.1 CDS hypC NC_004741.1 2814824 2815096 D HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 2814824..2815096 Shigella flexneri 2a str. 2457T 1079202 NP_838254.1 CDS hypD NC_004741.1 2815096 2816217 D residues 1 to 373 of 373 are 99.73 pct identical to residues 1 to 373 of 373 from Escherichia coli K-12 : B2729; pleiotrophic effects on 3 hydrogenase isozymes; hydrogenase isoenzyme HypD 2815096..2816217 Shigella flexneri 2a str. 2457T 1079203 NP_838255.1 CDS hypE NC_004741.1 2816256 2817224 D residues 1 to 322 of 322 are 98.44 pct identical to residues 1 to 322 of 322 from Escherichia coli K-12 : B2730; has structural role in maturation of all 3 hydrogenases; hypE product 2816256..2817224 Shigella flexneri 2a str. 2457T 1079204 NP_838256.1 CDS fhlA NC_004741.1 2817298 2819376 D residues 1 to 692 of 692 are 96.67 pct identical to residues 1 to 692 of 692 from Escherichia coli K-12 : B2731; formate hydrogen-lyase transcriptional activator for fdhF, hyc and hyp operons 2817298..2819376 Shigella flexneri 2a str. 2457T 1079205 NP_838257.1 CDS ygbA NC_004741.1 2819413 2819766 R residues 1 to 117 of 117 are 99.14 pct identical to residues 1 to 117 of 117 from Escherichia coli K-12 : B2732; hypothetical protein complement(2819413..2819766) Shigella flexneri 2a str. 2457T 1079206 NP_838258.1 CDS S2942 NC_004741.1 2819829 2820332 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(2819829..2820332) Shigella flexneri 2a str. 2457T 1079207 NP_838259.1 CDS S2943 NC_004741.1 2820251 2820526 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(2820251..2820526) Shigella flexneri 2a str. 2457T 1079208 NP_838260.1 CDS mutS NC_004741.1 2820830 2823391 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2820830..2823391 Shigella flexneri 2a str. 2457T 1079209 NP_838261.1 CDS ygbI NC_004741.1 2824200 2824997 R residues 1 to 265 of 265 are 98.11 pct identical to residues 1 to 265 of 265 from Escherichia coli K-12 : B2735; DEOR-type transcriptional regulator complement(2824200..2824997) Shigella flexneri 2a str. 2457T 1079211 NP_838262.1 CDS S2949 NC_004741.1 2826353 2826655 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 2826353..2826655 Shigella flexneri 2a str. 2457T 1079214 NP_838263.1 CDS S2950 NC_004741.1 2826796 2827509 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAB86997.1| (U97492) hypothetical 31 KD protein [Shigella flexneri]; IS600 orfB 2826796..2827509 Shigella flexneri 2a str. 2457T 1079215 NP_838264.1 CDS S2951 NC_004741.1 2827837 2829933 R residues 4 to 698 of 698 are 75.10 pct identical to residues 2 to 696 of 696 from GenPept : >dbj|BAB38368.1| (AP002567) phage transposase [Escherichia coli O157:H7]; phage transposase complement(2827837..2829933) Shigella flexneri 2a str. 2457T 1079216 NP_838265.1 CDS S2952 NC_004741.1 2829935 2830186 R residues 1 to 83 of 83 are 54.21 pct identical to residues 1 to 82 of 82 from GenPept : >dbj|BAB38367.1| (AP002567) DNA-binding protein [Escherichia coli O157:H7]; DNA-binding protein complement(2829935..2830186) Shigella flexneri 2a str. 2457T 1079217 NP_838266.1 CDS S2953 NC_004741.1 2830351 2830914 D residues 11 to 184 of 187 are 42.69 pct identical to residues 2 to 175 of 176 from GenPept : >dbj|BAB38366.1| (AP002567) regulatory protein [Escherichia coli O157:H7]; regulatory protein 2830351..2830914 Shigella flexneri 2a str. 2457T 1079218 NP_838267.1 CDS yclC NC_004741.1 2831184 2832134 R residues 1 to 316 of 316 are 97.15 pct identical to residues 1 to 316 of 475 from GenPept : >gb|AAG57845.1|AE005501_14 (AE005501) orf; hypothetical protein [Escherichia coli O157:H7 EDL933]; 4-hydroxybenzoate decarboxylase complement(2831184..2832134) Shigella flexneri 2a str. 2457T 1079219 NP_838268.1 CDS padI NC_004741.1 2832134 2832727 R residues 1 to 197 of 197 are 100.00 pct identical to residues 1 to 197 of 197 from GenPept : >gb|AAG14986.1|AF242210_5 (AF242210) phenylacrylic acid decarboxylase-like protein [Escherichia coli]; phenylacrylic acid decarboxylase-like protein complement(2832134..2832727) Shigella flexneri 2a str. 2457T 1079220 NP_838269.1 CDS S2956 NC_004741.1 2832874 2833281 D residues 1 to 135 of 135 are 97.03 pct identical to residues 1 to 135 of 135 from GenPept : >gb|AAG14991.1|AF242211_3 (AF242211) transcriptional regulator protein [Escherichia coli]; transcriptional regulator 2832874..2833281 Shigella flexneri 2a str. 2457T 1079221 NP_838270.1 CDS nlpD NC_004741.1 2834455 2835594 R outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD complement(2834455..2835594) Shigella flexneri 2a str. 2457T 1079223 NP_838271.1 CDS pcm NC_004741.1 2835734 2836360 R catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase complement(2835734..2836360) Shigella flexneri 2a str. 2457T 1079224 NP_838272.1 CDS surE NC_004741.1 2836354 2837115 R catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE complement(2836354..2837115) Shigella flexneri 2a str. 2457T 1079225 NP_838273.1 CDS truD NC_004741.1 2837096 2838145 R catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D complement(2837096..2838145) Shigella flexneri 2a str. 2457T 1079226 NP_838274.1 CDS ispF NC_004741.1 2838142 2838621 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(2838142..2838621) Shigella flexneri 2a str. 2457T 1079227 NP_838275.1 CDS ispD NC_004741.1 2838621 2839331 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(2838621..2839331) Shigella flexneri 2a str. 2457T 1079228 NP_838276.1 CDS ftsB NC_004741.1 2839350 2839661 R forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB complement(2839350..2839661) Shigella flexneri 2a str. 2457T 1079229 NP_838277.1 CDS ygbE NC_004741.1 2839855 2840178 R residues 1 to 107 of 107 are 99.06 pct identical to residues 1 to 107 of 107 from Escherichia coli K-12 : B2749; hypothetical protein complement(2839855..2840178) Shigella flexneri 2a str. 2457T 1079230 NP_838278.1 CDS cysC NC_004741.1 2840228 2840833 R converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase complement(2840228..2840833) Shigella flexneri 2a str. 2457T 1079231 NP_838279.1 CDS cysN NC_004741.1 2840833 2842260 R may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 complement(2840833..2842260) Shigella flexneri 2a str. 2457T 1079232 NP_838280.1 CDS cysD NC_004741.1 2842262 2843170 R with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 complement(2842262..2843170) Shigella flexneri 2a str. 2457T 1079233 NP_838281.1 CDS iap NC_004741.1 2843422 2844459 D catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase isozyme conversion aminopeptidase 2843422..2844459 Shigella flexneri 2a str. 2457T 1079234 NP_838282.1 CDS cysH NC_004741.1 2846306 2847040 R catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase complement(2846306..2847040) Shigella flexneri 2a str. 2457T 1079236 NP_838283.1 CDS cysI NC_004741.1 2847114 2848826 R hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta complement(2847114..2848826) Shigella flexneri 2a str. 2457T 1079237 NP_838284.1 CDS cysJ NC_004741.1 2848826 2850625 R catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha complement(2848826..2850625) Shigella flexneri 2a str. 2457T 1079238 NP_838285.1 CDS ygcM NC_004741.1 2850944 2851306 D residues 1 to 120 of 120 are 100.00 pct identical to residues 2 to 121 of 121 from Escherichia coli K-12 : B2765; 6-pyruvoyl tetrahydrobiopterin synthase 2850944..2851306 Shigella flexneri 2a str. 2457T 1079239 NP_838286.1 CDS ygcN NC_004741.1 2851354 2852655 D residues 1 to 433 of 433 are 89.37 pct identical to residues 1 to 433 of 433 from Escherichia coli K-12 : B2766; hypothetical protein 2851354..2852655 Shigella flexneri 2a str. 2457T 1079240 NP_838287.1 CDS ygcO NC_004741.1 2852610 2852906 D residues 1 to 98 of 98 are 92.85 pct identical to residues 1 to 98 of 98 from Escherichia coli K-12 : B2767; hypothetical protein 2852610..2852906 Shigella flexneri 2a str. 2457T 1079241 NP_838288.1 CDS ygcQ NC_004741.1 2853646 2854539 R residues 1 to 297 of 297 are 97.30 pct identical to residues 1 to 297 of 297 from Escherichia coli K-12 : B2769; flavoprotein complement(2853646..2854539) Shigella flexneri 2a str. 2457T 1079243 NP_838289.1 CDS ygcR NC_004741.1 2854503 2855282 R residues 1 to 259 of 259 are 93.05 pct identical to residues 3 to 261 of 261 from Escherichia coli K-12 : B2770; transporter complement(2854503..2855282) Shigella flexneri 2a str. 2457T 1079244 NP_838290.1 CDS ygcS NC_004741.1 2855260 2856669 R residues 1 to 469 of 469 are 74.84 pct identical to residues 1 to 469 of 469 from Escherichia coli K-12 : B2771; transporter complement(2855260..2856669) Shigella flexneri 2a str. 2457T 1079245 NP_838291.1 CDS S2981 NC_004741.1 2856691 2857485 R residues 1 to 264 of 264 are 99.24 pct identical to residues 1 to 264 of 264 from Escherichia coli K-12 : B2772; hypothetical protein complement(2856691..2857485) Shigella flexneri 2a str. 2457T 1079246 NP_838292.1 CDS S2982 NC_004741.1 2857600 2857875 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2857600..2857875 Shigella flexneri 2a str. 2457T 1079247 NP_838293.1 CDS S2983 NC_004741.1 2857794 2858297 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2857794..2858297 Shigella flexneri 2a str. 2457T 1079248 NP_838294.1 CDS ygcF NC_004741.1 2858336 2859007 R residues 1 to 223 of 223 are 93.27 pct identical to residues 1 to 223 of 223 from Escherichia coli K-12 : B2777; hypothetical protein complement(2858336..2859007) Shigella flexneri 2a str. 2457T 1079249 NP_838295.1 CDS S2985 NC_004741.1 2859401 2859676 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2859401..2859676 Shigella flexneri 2a str. 2457T 1079250 NP_838296.1 CDS S2986 NC_004741.1 2859595 2860098 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 2859595..2860098 Shigella flexneri 2a str. 2457T 1079251 NP_838297.1 CDS eno NC_004741.1 2860969 2862267 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(2860969..2862267) Shigella flexneri 2a str. 2457T 1079253 NP_838298.1 CDS pyrG NC_004741.1 2862355 2863992 R CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(2862355..2863992) Shigella flexneri 2a str. 2457T 1079254 NP_838299.1 CDS mazG NC_004741.1 2864220 2865011 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase complement(2864220..2865011) Shigella flexneri 2a str. 2457T 1079255 NP_838300.1 CDS relA NC_004741.1 2865107 2867341 R (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase complement(2865107..2867341) Shigella flexneri 2a str. 2457T 1079256 NP_838301.1 CDS rumA NC_004741.1 2867389 2868690 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(2867389..2868690) Shigella flexneri 2a str. 2457T 1079257 NP_838302.1 CDS barA NC_004741.1 2868747 2871503 D part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 2868747..2871503 Shigella flexneri 2a str. 2457T 1079258 NP_838303.1 CDS ygcX NC_004741.1 2871735 2873075 R residues 1 to 446 of 446 are 99.77 pct identical to residues 1 to 446 of 446 from Escherichia coli K-12 : B2787; glucarate dehydratase complement(2871735..2873075) Shigella flexneri 2a str. 2457T 1079259 NP_838304.1 CDS ygcY NC_004741.1 2873096 2874436 R residues 1 to 446 of 446 are 94.61 pct identical to residues 1 to 446 of 446 from Escherichia coli K-12 : B2788; glucarate dehydratase complement(2873096..2874436) Shigella flexneri 2a str. 2457T 1079260 NP_838305.1 CDS S2996 NC_004741.1 2874438 2875790 R residues 1 to 450 of 450 are 99.33 pct identical to residues 1 to 450 of 450 from Escherichia coli K-12 : B2789; transporter complement(2874438..2875790) Shigella flexneri 2a str. 2457T 1079262 NP_838306.1 CDS S2997 NC_004741.1 2876224 2876673 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(2876224..2876673) Shigella flexneri 2a str. 2457T 1079263 NP_838307.1 CDS yqcB NC_004741.1 2876691 2877473 R catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C complement(2876691..2877473) Shigella flexneri 2a str. 2457T 1079264 NP_838308.1 CDS S2999 NC_004741.1 2877473 2877802 R residues 1 to 109 of 109 are 85.32 pct identical to residues 1 to 109 of 109 from Escherichia coli K-12 : B2792; hypothetical protein complement(2877473..2877802) Shigella flexneri 2a str. 2457T 1079265 NP_838309.1 CDS syd NC_004741.1 2878424 2878969 R SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd complement(2878424..2878969) Shigella flexneri 2a str. 2457T 1079267 NP_838310.1 CDS queF NC_004741.1 2879037 2879885 D catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 2879037..2879885 Shigella flexneri 2a str. 2457T 1079268 NP_838311.1 CDS ygdH NC_004741.1 2879997 2881361 D residues 1 to 454 of 454 are 100.00 pct identical to residues 1 to 454 of 454 from Escherichia coli K-12 : B2795; hypothetical protein 2879997..2881361 Shigella flexneri 2a str. 2457T 1079269 NP_838312.1 CDS S3004 NC_004741.1 2881463 2882797 D residues 1 to 437 of 444 are 99.77 pct identical to residues 7 to 443 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 2881463..2882797 Shigella flexneri 2a str. 2457T 1079270 NP_838313.1 CDS sdaC NC_004741.1 2883357 2884646 D residues 1 to 429 of 429 are 96.27 pct identical to residues 1 to 429 of 429 from Escherichia coli K-12 : B2796; serine transporter 2883357..2884646 Shigella flexneri 2a str. 2457T 1079271 NP_838314.1 CDS sdaB NC_004741.1 2884704 2886071 D residues 1 to 455 of 455 are 90.76 pct identical to residues 1 to 455 of 455 from Escherichia coli K-12 : B2797; L-serine dehydratase (deaminase), L-SD2 2884704..2886071 Shigella flexneri 2a str. 2457T 1079272 NP_838315.1 CDS xni NC_004741.1 2886092 2886937 D has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 2886092..2886937 Shigella flexneri 2a str. 2457T 1079970 NP_838316.1 CDS fucO NC_004741.1 2886990 2888138 R residues 1 to 382 of 382 are 99.47 pct identical to residues 2 to 383 of 383 from Escherichia coli K-12 : B2799; L-1,2-propanediol oxidoreductase complement(2886990..2888138) Shigella flexneri 2a str. 2457T 1079273 NP_838317.1 CDS fucA NC_004741.1 2888166 2888813 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(2888166..2888813) Shigella flexneri 2a str. 2457T 1079274 NP_838318.1 CDS fucP NC_004741.1 2889360 2890676 D residues 1 to 438 of 438 are 89.49 pct identical to residues 1 to 438 of 438 from Escherichia coli K-12 : B2801; L-fucose transporter 2889360..2890676 Shigella flexneri 2a str. 2457T 1079275 NP_838319.1 CDS fucI NC_004741.1 2890709 2892484 D catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2890709..2892484 Shigella flexneri 2a str. 2457T 1079277 NP_838320.1 CDS fucU NC_004741.1 2894014 2894436 D residues 1 to 140 of 140 are 99.28 pct identical to residues 1 to 140 of 140 from Escherichia coli K-12 : B2804; protein of fucose operon 2894014..2894436 Shigella flexneri 2a str. 2457T 1078544 NP_838321.1 CDS fucR NC_004741.1 2894494 2895225 D regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 2894494..2895225 Shigella flexneri 2a str. 2457T 1079279 NP_838322.1 CDS ygdE NC_004741.1 2895269 2896369 R residues 1 to 366 of 366 are 99.72 pct identical to residues 1 to 366 of 366 from Escherichia coli K-12 : B2806; RNA 2'-O-ribose methyltransferase complement(2895269..2896369) Shigella flexneri 2a str. 2457T 1079281 NP_838323.1 CDS ygdD NC_004741.1 2896362 2896757 R residues 1 to 131 of 131 are 100.00 pct identical to residues 1 to 131 of 131 from Escherichia coli K-12 : B2807; hypothetical protein complement(2896362..2896757) Shigella flexneri 2a str. 2457T 1079282 NP_838324.1 CDS gcvA NC_004741.1 2896776 2897693 R Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA complement(2896776..2897693) Shigella flexneri 2a str. 2457T 1079283 NP_838325.1 CDS S3018 NC_004741.1 2898044 2898274 R residues 1 to 76 of 76 are 97.36 pct identical to residues 1 to 76 of 76 from Escherichia coli K-12 : B2809; hypothetical protein complement(2898044..2898274) Shigella flexneri 2a str. 2457T 1079285 NP_838326.1 CDS S3019 NC_004741.1 2898463 2899668 D residues 1 to 401 of 401 are 98.75 pct identical to residues 1 to 401 of 401 from Escherichia coli K-12 : B2810; cysteine sulfinate desulfinase 2898463..2899668 Shigella flexneri 2a str. 2457T 1079286 NP_838327.1 CDS ygdK NC_004741.1 2899668 2900111 D residues 1 to 147 of 147 are 98.63 pct identical to residues 1 to 147 of 147 from Escherichia coli K-12 : B2811; hypothetical protein 2899668..2900111 Shigella flexneri 2a str. 2457T 1079287 NP_838328.1 CDS ygdL NC_004741.1 2900162 2900968 R residues 1 to 268 of 268 are 99.62 pct identical to residues 1 to 268 of 268 from Escherichia coli K-12 : B2812; enzyme complement(2900162..2900968) Shigella flexneri 2a str. 2457T 1079289 NP_838329.1 CDS mltA NC_004741.1 2901206 2902303 R membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A complement(2901206..2902303) Shigella flexneri 2a str. 2457T 1079291 NP_838330.1 CDS S3025 NC_004741.1 2902773 2904116 R residues 1 to 447 of 447 are 92.61 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 : B2817; amidase complement(2902773..2904116) Shigella flexneri 2a str. 2457T 1079293 NP_838331.1 CDS argA NC_004741.1 2904258 2905589 D catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 2904258..2905589 Shigella flexneri 2a str. 2457T 1079294 NP_838332.1 CDS recD NC_004741.1 2905651 2907477 R helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha complement(2905651..2907477) Shigella flexneri 2a str. 2457T 1079295 NP_838333.1 CDS recB NC_004741.1 2907477 2911019 R helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta complement(2907477..2911019) Shigella flexneri 2a str. 2457T 1079296 NP_838334.1 CDS ptr NC_004741.1 2911012 2913900 R residues 1 to 962 of 962 are 99.68 pct identical to residues 1 to 962 of 962 from Escherichia coli K-12 : B2821; protease III complement(2911012..2913900) Shigella flexneri 2a str. 2457T 1079298 NP_838335.1 CDS recC NC_004741.1 2914076 2917444 R catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma complement(2914076..2917444) Shigella flexneri 2a str. 2457T 1079299 NP_838336.1 CDS ppdC NC_004741.1 2917457 2917807 R residues 1 to 116 of 116 are 81.03 pct identical to residues 1 to 107 of 107 from Escherichia coli K-12 : B2823; hypothetical protein complement(2917457..2917807) Shigella flexneri 2a str. 2457T 1079300 NP_838337.2 CDS ygdB NC_004741.1 2917792 2918199 R residues 16 to 121 of 121 are 96.22 pct identical to residues 16 to 121 of 121 from Escherichia coli K-12 : B2824; hypothetical protein complement(2917792..2918199) Shigella flexneri 2a str. 2457T 1079301 NP_838338.1 CDS ppdB NC_004741.1 2918196 2918759 R residues 1 to 187 of 187 are 98.39 pct identical to residues 1 to 187 of 187 from Escherichia coli K-12 : B2825; hypothetical protein complement(2918196..2918759) Shigella flexneri 2a str. 2457T 1079303 NP_838339.1 CDS thyA NC_004741.1 2919404 2920198 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(2919404..2920198) Shigella flexneri 2a str. 2457T 1079305 NP_838340.1 CDS lgt NC_004741.1 2920205 2921080 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(2920205..2921080) Shigella flexneri 2a str. 2457T 1079306 NP_838341.1 CDS ptsP NC_004741.1 2921231 2923477 R member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain complement(2921231..2923477) Shigella flexneri 2a str. 2457T 1079307 NP_838342.1 CDS ygdP NC_004741.1 2923490 2924020 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(2923490..2924020) Shigella flexneri 2a str. 2457T 1079308 NP_838343.1 CDS mutH NC_004741.1 2924705 2925394 D MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 2924705..2925394 Shigella flexneri 2a str. 2457T 1078444 NP_838344.1 CDS S3040 NC_004741.1 2925463 2926176 D residues 1 to 237 of 237 are 76.37 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B2832; transporter 2925463..2926176 Shigella flexneri 2a str. 2457T 1079309 NP_838345.1 CDS S3041 NC_004741.1 2926314 2926532 D residues 1 to 72 of 72 are 100.00 pct identical to residues 1 to 72 of 72 from Escherichia coli K-12 : B2833; hypothetical protein 2926314..2926532 Shigella flexneri 2a str. 2457T 1078237 NP_838346.1 CDS tas NC_004741.1 2926640 2927680 D complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo-keto reductase 2926640..2927680 Shigella flexneri 2a str. 2457T 1079759 NP_838347.1 CDS ygeD NC_004741.1 2927713 2928903 R residues 1 to 396 of 396 are 84.63 pct identical to residues 1 to 397 of 397 from Escherichia coli K-12 : B2835; lysophospholipid transporter LplT complement(2927713..2928903) Shigella flexneri 2a str. 2457T 1079310 NP_838348.1 CDS aas NC_004741.1 2928896 2931055 R Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase complement(2928896..2931055) Shigella flexneri 2a str. 2457T 1079311 NP_838349.1 CDS galR NC_004741.1 2931641 2932672 D controls transcription of galETKM; DNA-binding transcriptional regulator GalR 2931641..2932672 Shigella flexneri 2a str. 2457T 1079312 NP_838350.1 CDS lysA NC_004741.1 2932679 2933941 R catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase complement(2932679..2933941) Shigella flexneri 2a str. 2457T 1079313 NP_838351.1 CDS lysR NC_004741.1 2934063 2934998 D activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 2934063..2934998 Shigella flexneri 2a str. 2457T 1079314 NP_838352.1 CDS ygeA NC_004741.1 2934985 2935677 R residues 1 to 230 of 230 are 99.13 pct identical to residues 1 to 230 of 230 from Escherichia coli K-12 : B2840; racemase complement(2934985..2935677) Shigella flexneri 2a str. 2457T 1079315 NP_838353.1 CDS araE NC_004741.1 2935806 2937224 R residues 1 to 472 of 472 are 94.06 pct identical to residues 1 to 472 of 472 from Escherichia coli K-12 : B2841; low-affinity L-arabinose transport system proton symport protein complement(2935806..2937224) Shigella flexneri 2a str. 2457T 1080182 NP_838354.1 CDS kduD NC_004741.1 2937539 2938300 R catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase complement(2937539..2938300) Shigella flexneri 2a str. 2457T 1079520 NP_838355.1 CDS kduI NC_004741.1 2938330 2939166 R 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase complement(2938330..2939166) Shigella flexneri 2a str. 2457T 1079316 NP_838356.1 CDS yqeF NC_004741.1 2939453 2940634 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase complement(2939453..2940634) Shigella flexneri 2a str. 2457T 1079318 NP_838357.1 CDS S3053 NC_004741.1 2941000 2942118 D residues 1 to 372 of 372 are 99.19 pct identical to residues 38 to 409 of 409 from Escherichia coli K-12 : B2845; transporter protein 2941000..2942118 Shigella flexneri 2a str. 2457T 1078306 NP_838358.1 CDS S3055 NC_004741.1 2942753 2943052 D residues 1 to 99 of 99 are 100.00 pct identical to residues 1 to 99 of 99 from GenPept : >gb|AAL57580.1|AF453442_9 (AF453442) transposase 2 [Escherichia coli]; IS3 orfA 2942753..2943052 Shigella flexneri 2a str. 2457T 1079319 NP_838359.1 CDS S3056 NC_004741.1 2943049 2943915 D residues 1 to 288 of 288 are 99.30 pct identical to residues 1 to 288 of 288 from GenPept : >gb|AAL57519.1|AF453441_3 (AF453441) transposase 1 [Escherichia coli]; IS3 orfB 2943049..2943915 Shigella flexneri 2a str. 2457T 1079321 NP_838360.1 CDS S3059 NC_004741.1 2945154 2946143 R residues 5 to 326 of 329 are 92.54 pct identical to residues 4 to 325 of 327 from GenPept : >emb|CAD02863.1| (AL627277) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(2945154..2946143) Shigella flexneri 2a str. 2457T 1079325 NP_838361.1 CDS S3060 NC_004741.1 2946227 2946718 R residues 1 to 163 of 163 are 79.75 pct identical to residues 1 to 163 of 163 from GenPept : >emb|CAD02864.1| (AL627277) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(2946227..2946718) Shigella flexneri 2a str. 2457T 1077055 NP_838362.1 CDS S3062 NC_004741.1 2947016 2947762 R residues 17 to 116 of 248 are 40.77 pct identical to residues 19 to 116 of 280 from GenPept : >emb|CAD09973.1| (AL513384) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(2947016..2947762) Shigella flexneri 2a str. 2457T 1079326 NP_838363.1 CDS S3063 NC_004741.1 2948881 2949213 R no significant similarities; hypothetical protein complement(2948881..2949213) Shigella flexneri 2a str. 2457T 1079327 NP_838364.1 CDS S3064 NC_004741.1 2949332 2950942 R residues 1 to 511 of 536 are 96.67 pct identical to residues 1 to 511 of 548 from GenPept : >emb|CAD02867.1| (AL627277) possible integrase [Salmonella enterica subsp. enterica serovar Typhi]; integrase complement(2949332..2950942) Shigella flexneri 2a str. 2457T 1079328 NP_838365.1 CDS S3067 NC_004741.1 2951229 2952008 R residues 2 to 260 of 260 are 89.18 pct identical to residues 1 to 259 of 259 from Escherichia coli K-12 : B2865; lipoprotein complement(2951229..2952008) Shigella flexneri 2a str. 2457T 1079329 NP_838366.1 CDS S3068 NC_004741.1 2952399 2954696 D molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 2952399..2954696 Shigella flexneri 2a str. 2457T 1079331 NP_838367.1 CDS ygeT NC_004741.1 2954707 2955585 D FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 2954707..2955585 Shigella flexneri 2a str. 2457T 1079320 NP_838368.1 CDS S3070 NC_004741.1 2955582 2956061 D iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 2955582..2956061 Shigella flexneri 2a str. 2457T 1079332 NP_838369.1 CDS S3071 NC_004741.1 2956174 2956449 D residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2956174..2956449 Shigella flexneri 2a str. 2457T 1079333 NP_838370.1 CDS S3072 NC_004741.1 2956368 2956871 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2956368..2956871 Shigella flexneri 2a str. 2457T 1079334 NP_838371.1 CDS ygfU NC_004741.1 2957303 2958820 D residues 1 to 505 of 505 are 99.00 pct identical to residues 1 to 505 of 505 from Escherichia coli K-12 : B2888; permease 2957303..2958820 Shigella flexneri 2a str. 2457T 1080977 NP_838372.1 CDS S3074 NC_004741.1 2959070 2959618 D catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 2959070..2959618 Shigella flexneri 2a str. 2457T 1079336 NP_838373.1 CDS lysS NC_004741.1 2959661 2961178 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(2959661..2961178) Shigella flexneri 2a str. 2457T 1079763 NP_838374.1 CDS prfB NC_004741.1 2961188 2962286 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(join(2961188..2962210,2962212..2962286)) Shigella flexneri 2a str. 2457T 1079337 NP_838375.1 CDS recJ NC_004741.1 2962377 2964110 R 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ complement(2962377..2964110) Shigella flexneri 2a str. 2457T 1079338 NP_838376.1 CDS dsbC NC_004741.1 2964116 2964826 R DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC complement(2964116..2964826) Shigella flexneri 2a str. 2457T 1079339 NP_838377.1 CDS xerD NC_004741.1 2964851 2965747 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(2964851..2965747) Shigella flexneri 2a str. 2457T 1076571 NP_838378.1 CDS fldB NC_004741.1 2965859 2966380 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 2965859..2966380 Shigella flexneri 2a str. 2457T 1079340 NP_838379.1 CDS S3081 NC_004741.1 2966420 2966827 R residues 1 to 135 of 135 are 99.25 pct identical to residues 1 to 135 of 135 from Escherichia coli K-12 : B2896; hypothetical protein complement(2966420..2966827) Shigella flexneri 2a str. 2457T 1079341 NP_838380.1 CDS ygfY NC_004741.1 2966808 2967074 R residues 1 to 88 of 88 are 100.00 pct identical to residues 1 to 88 of 88 from Escherichia coli K-12 : B2897; hypothetical protein complement(2966808..2967074) Shigella flexneri 2a str. 2457T 1079342 NP_838381.1 CDS ygfZ NC_004741.1 2967317 2968297 D physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 2967317..2968297 Shigella flexneri 2a str. 2457T 1079343 NP_838382.1 CDS S3084 NC_004741.1 2968493 2969152 R residues 1 to 219 of 219 are 92.69 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B2899; oxidoreductase complement(2968493..2969152) Shigella flexneri 2a str. 2457T 1079344 NP_838383.1 CDS bglA NC_004741.1 2969671 2971104 D residues 1 to 477 of 477 are 95.59 pct identical to residues 3 to 479 of 479 from Escherichia coli K-12 : B2901; 6-phospho-beta-glucosidase 2969671..2971104 Shigella flexneri 2a str. 2457T 1076479 NP_838384.1 CDS ygfF NC_004741.1 2971161 2971904 R residues 1 to 247 of 247 are 99.19 pct identical to residues 1 to 247 of 247 from Escherichia coli K-12 : B2902; hypothetical protein complement(2971161..2971904) Shigella flexneri 2a str. 2457T 1079346 NP_838385.1 CDS gcvP NC_004741.1 2972171 2975044 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase complement(2972171..2975044) Shigella flexneri 2a str. 2457T 1079347 NP_838386.1 CDS gcvH NC_004741.1 2975163 2975552 R part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H complement(2975163..2975552) Shigella flexneri 2a str. 2457T 1079349 NP_838387.1 CDS gcvT NC_004741.1 2975576 2976670 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(2975576..2976670) Shigella flexneri 2a str. 2457T 1079350 NP_838388.1 CDS visC NC_004741.1 2977118 2978320 R residues 1 to 400 of 400 are 97.50 pct identical to residues 1 to 400 of 400 from Escherichia coli K-12 : B2906; hypothetical protein complement(2977118..2978320) Shigella flexneri 2a str. 2457T 1079351 NP_838389.1 CDS ubiH NC_004741.1 2978343 2979521 R Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase complement(2978343..2979521) Shigella flexneri 2a str. 2457T 1079352 NP_838390.1 CDS pepP NC_004741.1 2979518 2980843 R exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II complement(2979518..2980843) Shigella flexneri 2a str. 2457T 1079353 NP_838391.1 CDS ygfB NC_004741.1 2980869 2981447 R the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein complement(2980869..2981447) Shigella flexneri 2a str. 2457T 1079355 NP_838392.1 CDS ygfE NC_004741.1 2981615 2981944 D residues 1 to 109 of 109 are 100.00 pct identical to residues 1 to 109 of 109 from Escherichia coli K-12 : B2910; Z-ring-associated protein 2981615..2981944 Shigella flexneri 2a str. 2457T 1079356 NP_838393.1 CDS ygfA NC_004741.1 2982244 2982792 D ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 2982244..2982792 Shigella flexneri 2a str. 2457T 1079357 NP_838394.1 CDS serA NC_004741.1 2983573 2984805 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(2983573..2984805) Shigella flexneri 2a str. 2457T 1079696 NP_838395.1 CDS rpiA NC_004741.1 2985061 2985720 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(2985061..2985720) Shigella flexneri 2a str. 2457T 1079359 NP_838396.1 CDS iciA NC_004741.1 2986103 2986996 D specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 2986103..2986996 Shigella flexneri 2a str. 2457T 1079361 NP_838397.1 CDS sbm NC_004741.1 2987200 2989344 D MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 2987200..2989344 Shigella flexneri 2a str. 2457T 1079363 NP_838398.1 CDS ygfD NC_004741.1 2989337 2990332 D functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 2989337..2990332 Shigella flexneri 2a str. 2457T 1079365 NP_838399.2 CDS ygfG NC_004741.1 2990343 2991128 D catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 2990343..2991128 Shigella flexneri 2a str. 2457T 1079366 NP_838400.1 CDS ygfI NC_004741.1 2992572 2993522 R residues 1 to 285 of 316 are 94.38 pct identical to residues 6 to 290 of 303 from Escherichia coli K-12 : B2921; LYSR-type transcriptional regulator complement(2992572..2993522) Shigella flexneri 2a str. 2457T 1079367 NP_838401.1 CDS yggE NC_004741.1 2993689 2994429 R residues 1 to 246 of 246 are 94.71 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B2922; hypothetical protein complement(2993689..2994429) Shigella flexneri 2a str. 2457T 1079368 NP_838402.1 CDS yggA NC_004741.1 2994522 2995157 R Involved in the export of arginine; arginine exporter protein complement(2994522..2995157) Shigella flexneri 2a str. 2457T 1079369 NP_838403.1 CDS yggB NC_004741.1 2995296 2996156 R participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS complement(2995296..2996156) Shigella flexneri 2a str. 2457T 1079370 NP_838404.1 CDS fba NC_004741.1 2996347 2997426 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(2996347..2997426) Shigella flexneri 2a str. 2457T 1079371 NP_838405.1 CDS pgk NC_004741.1 2997641 2998804 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(2997641..2998804) Shigella flexneri 2a str. 2457T 1079372 NP_838406.1 CDS epd NC_004741.1 2998854 2999873 R NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase complement(2998854..2999873) Shigella flexneri 2a str. 2457T 1079373 NP_838407.1 CDS S3113 NC_004741.1 3000407 3000676 D residues 1 to 89 of 89 are 98.87 pct identical to residues 55 to 143 of 143 from GenPept : >gb|AAG58054.1|AE005523_3 (AE005523) orf; hypothetical protein [Escherichia coli O157:H7 EDL933]; DNA-binding protein 3000407..3000676 Shigella flexneri 2a str. 2457T 1079374 NP_838408.1 CDS S3114 NC_004741.1 3000699 3001277 D residues 1 to 192 of 192 are 81.25 pct identical to residues 1 to 192 of 192 from GenPept : >gb|AAG58055.1|AE005523_4 (AE005523) orf; hypothetical protein [Escherichia coli O157:H7 EDL933]; inner membrane protein 3000699..3001277 Shigella flexneri 2a str. 2457T 1079375 NP_838409.1 CDS S3115 NC_004741.1 3001278 3001586 D residues 1 to 102 of 102 are 83.33 pct identical to residues 1 to 102 of 235 from GenPept : >gb|AAG58056.1|AE005523_5 (AE005523) orf; hypothetical protein [Escherichia coli O157:H7 EDL933]; lipoprotein 3001278..3001586 Shigella flexneri 2a str. 2457T 1079377 NP_838410.1 CDS S3116 NC_004741.1 3001587 3001985 D residues 1 to 132 of 132 are 99.24 pct identical to residues 104 to 235 of 235 from GenPept : >gb|AAG58056.1|AE005523_5 (AE005523) orf; hypothetical protein [Escherichia coli O157:H7 EDL933]; lipoprotein 3001587..3001985 Shigella flexneri 2a str. 2457T 1079378 NP_838411.1 CDS S3117 NC_004741.1 3001973 3002650 D residues 1 to 225 of 225 are 91.55 pct identical to residues 1 to 225 of 225 from GenPept : >gb|AAG58057.1|AE005523_6 (AE005523) ATP-binding protein of ABC transport system [Escherichia coli O157:H7 EDL933]; ATP-binding protein of ABC transport system 3001973..3002650 Shigella flexneri 2a str. 2457T 1079379 NP_838412.1 CDS S3118 NC_004741.1 3002644 3003321 D residues 1 to 225 of 225 are 90.22 pct identical to residues 1 to 225 of 225 from GenPept : >dbj|BAB37226.1| (AP002563) ABC-transporter ATP-binding subunit [Escherichia coli O157:H7]; ATP-binding protein of ABC transport system 3002644..3003321 Shigella flexneri 2a str. 2457T 1079380 NP_838413.1 CDS yggD NC_004741.1 3004003 3004512 R residues 1 to 151 of 169 are 96.68 pct identical to residues 1 to 151 of 169 from Escherichia coli K-12 : B2929; DNA-binding transcriptional regulator complement(3004003..3004512) Shigella flexneri 2a str. 2457T 1079382 NP_838414.1 CDS yggF NC_004741.1 3004534 3005499 R residues 1 to 321 of 321 are 99.37 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B2930; fructose-1,6-bisphosphatase II-like protein complement(3004534..3005499) Shigella flexneri 2a str. 2457T 1079383 NP_838415.1 CDS S3122 NC_004741.1 3005496 3006485 R residues 1 to 329 of 329 are 98.78 pct identical to residues 1 to 329 of 329 from Escherichia coli K-12 : B2931; oxidoreductase complement(3005496..3006485) Shigella flexneri 2a str. 2457T 1079384 NP_838416.1 CDS S3124 NC_004741.1 3006739 3007242 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(3006739..3007242) Shigella flexneri 2a str. 2457T 1079386 NP_838417.1 CDS S3125 NC_004741.1 3007161 3007436 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3007161..3007436) Shigella flexneri 2a str. 2457T 1079388 NP_838418.1 CDS S3126 NC_004741.1 3007927 3008835 D residues 32 to 302 of 302 are 48.89 pct identical to residues 32 to 303 of 308 from GenPept : >emb|CAC90171.1| (AJ414147) SPFH domain protein [Yersinia pestis]; serine protease 3007927..3008835 Shigella flexneri 2a str. 2457T 1079389 NP_838419.1 CDS tktA NC_004741.1 3008881 3010872 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(3008881..3010872) Shigella flexneri 2a str. 2457T 1079392 NP_838420.1 CDS yggG NC_004741.1 3011024 3011908 D residues 1 to 294 of 294 are 92.85 pct identical to residues 1 to 294 of 294 from Escherichia coli K-12 : B2936; hypothetical protein 3011024..3011908 Shigella flexneri 2a str. 2457T 1079393 NP_838421.1 CDS speB NC_004741.1 3012114 3013034 R catalyzes the formation of putrescine from agmatine; agmatinase complement(3012114..3013034) Shigella flexneri 2a str. 2457T 1077797 NP_838422.1 CDS S3130 NC_004741.1 3013170 3013544 R residues 1 to 124 of 124 are 97.58 pct identical to residues 120 to 243 of 243 from GenPept : >gb|AAG58068.1|AE005524_4 (AE005524) Z4282 gene product [Escherichia coli O157:H7 EDL933]; lipoprotein complement(3013170..3013544) Shigella flexneri 2a str. 2457T 1079395 NP_838423.1 CDS S3131 NC_004741.1 3013570 3014073 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(3013570..3014073) Shigella flexneri 2a str. 2457T 1079397 NP_838424.1 CDS S3132 NC_004741.1 3013992 3014267 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3013992..3014267) Shigella flexneri 2a str. 2457T 1079398 NP_838425.1 CDS speA NC_004741.1 3014414 3016390 R catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase complement(3014414..3016390) Shigella flexneri 2a str. 2457T 1079399 NP_838426.1 CDS yqgB NC_004741.1 3016399 3016545 R residues 1 to 48 of 48 are 93.75 pct identical to residues 1 to 48 of 48 from Escherichia coli K-12 : B2939; hypothetical protein complement(3016399..3016545) Shigella flexneri 2a str. 2457T 1079400 NP_838427.1 CDS yqgC NC_004741.1 3016666 3016881 D residues 1 to 71 of 71 are 77.46 pct identical to residues 1 to 71 of 71 from Escherichia coli K-12 : B2940; hypothetical protein 3016666..3016881 Shigella flexneri 2a str. 2457T 1076489 NP_838428.1 CDS yqgD NC_004741.1 3016878 3017129 R residues 1 to 83 of 83 are 98.79 pct identical to residues 1 to 83 of 83 from Escherichia coli K-12 : B2941; hypothetical protein complement(3016878..3017129) Shigella flexneri 2a str. 2457T 1079401 NP_838429.1 CDS metK NC_004741.1 3017185 3018339 D methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3017185..3018339 Shigella flexneri 2a str. 2457T 1079402 NP_838430.1 CDS galP NC_004741.1 3018815 3020170 D residues 1 to 451 of 451 are 97.11 pct identical to residues 14 to 464 of 464 from Escherichia coli K-12 : B2943; major facilitator superfamily galactose-proton symporter 3018815..3020170 Shigella flexneri 2a str. 2457T 1078092 NP_838431.1 CDS sprT NC_004741.1 3020247 3020744 D residues 1 to 165 of 165 are 98.78 pct identical to residues 1 to 165 of 165 from Escherichia coli K-12 : B2944; hypothetical protein 3020247..3020744 Shigella flexneri 2a str. 2457T 1079403 NP_838432.1 CDS endA NC_004741.1 3020839 3021546 D residues 1 to 235 of 235 are 94.04 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B2945; DNA-specific endonuclease I 3020839..3021546 Shigella flexneri 2a str. 2457T 1079405 NP_838433.1 CDS yggJ NC_004741.1 3021626 3022357 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3021626..3022357 Shigella flexneri 2a str. 2457T 1079407 NP_838434.1 CDS gshB NC_004741.1 3022370 3023320 D The second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3022370..3023320 Shigella flexneri 2a str. 2457T 1079408 NP_838435.2 CDS yqgE NC_004741.1 3023429 3023992 D residues 1 to 211 of 211 are 100.00 pct identical to residues 1 to 211 of 211 from Escherichia coli K-12 : B2948; hypothetical protein 3023429..3023992 Shigella flexneri 2a str. 2457T 1079409 NP_838436.1 CDS yqgF NC_004741.1 3023992 3024408 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3023992..3024408 Shigella flexneri 2a str. 2457T 1079435 NP_838437.1 CDS yggR NC_004741.1 3024584 3025609 R residues 1 to 341 of 341 are 98.24 pct identical to residues 1 to 341 of 341 from Escherichia coli K-12 : B2950; transporter complement(3024584..3025609) Shigella flexneri 2a str. 2457T 1079411 NP_838438.1 CDS yggS NC_004741.1 3025582 3026286 D residues 1 to 234 of 234 are 93.16 pct identical to residues 1 to 234 of 234 from Escherichia coli K-12 : B2951; hypothetical protein 3025582..3026286 Shigella flexneri 2a str. 2457T 1079412 NP_838439.1 CDS yggT NC_004741.1 3026304 3026870 D residues 1 to 188 of 188 are 83.51 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 : B2952; resistance protein 3026304..3026870 Shigella flexneri 2a str. 2457T 1079413 NP_838440.2 CDS yggU NC_004741.1 3026867 3027157 D residues 1 to 100 of 100 are 85.00 pct identical to residues 1 to 100 of 100 from Escherichia coli K-12 : B2953; hypothetical protein 3026867..3027157 Shigella flexneri 2a str. 2457T 1079414 NP_838441.1 CDS yggV NC_004741.1 3027165 3027758 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 3027165..3027758 Shigella flexneri 2a str. 2457T 1079415 NP_838442.1 CDS yggW NC_004741.1 3027751 3028887 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3027751..3028887 Shigella flexneri 2a str. 2457T 1079416 NP_838443.1 CDS S3151 NC_004741.1 3029201 3029554 D residues 1 to 114 of 117 are 80.70 pct identical to residues 1 to 114 of 216 from NRprotein_Feb03 : >gb|AAF06334.1|AF193593_1 C4-dicarboxylate periplasmic binding protein precursor DctP [Klebsiella pneumoniae]; hypothetical protein 3029201..3029554 Shigella flexneri 2a str. 2457T 1079418 NP_838444.1 CDS S3152 NC_004741.1 3029571 3030164 D residues 1 to 191 of 197 are 52.60 pct identical to residues 116 to 307 of 312 from NRprotein_Feb03 : >ref|NP_762983.1| TRAP-type C4-dicarboxylate transport system, periplasmic component [Vibrio vulnificus CMCP6] gb|AAO07973.1|AE016811_214 TRAP-type C4-dicarboxylate transport system, periplasmic component [Vibrio vulnificus CMCP6]; hypothetical protein 3029571..3030164 Shigella flexneri 2a str. 2457T 1079419 NP_838445.1 CDS S3153 NC_004741.1 3030209 3030712 D residues 36 to 166 of 167 are 23.13 pct identical to residues 27 to 157 of 157 from Escherichia coli K-12 : B3577; hypothetical protein 3030209..3030712 Shigella flexneri 2a str. 2457T 1079420 NP_838446.1 CDS S3154 NC_004741.1 3031144 3031419 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3031144..3031419) Shigella flexneri 2a str. 2457T 1079421 NP_838447.1 CDS S3155 NC_004741.1 3031476 3032777 D residues 5 to 393 of 433 are 33.07 pct identical to residues 1 to 384 of 424 from Escherichia coli K-12 : B3578; hypothetical protein 3031476..3032777 Shigella flexneri 2a str. 2457T 1079422 NP_838448.1 CDS yggM NC_004741.1 3032878 3033840 R residues 1 to 320 of 320 are 99.37 pct identical to residues 1 to 320 of 335 from Escherichia coli K-12 : B2956; alpha helix chain complement(3032878..3033840) Shigella flexneri 2a str. 2457T 1078051 NP_838449.1 CDS ansB NC_004741.1 3033957 3035003 R catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II complement(3033957..3035003) Shigella flexneri 2a str. 2457T 1079423 NP_838450.1 CDS yggN NC_004741.1 3035179 3035895 R residues 1 to 238 of 238 are 99.57 pct identical to residues 2 to 239 of 239 from Escherichia coli K-12 : B2958; hypothetical protein complement(3035179..3035895) Shigella flexneri 2a str. 2457T 1079424 NP_838451.2 CDS yggL NC_004741.1 3036082 3036408 R residues 1 to 118 of 118 are 98.30 pct identical to residues 1 to 118 of 118 from Escherichia coli K-12 : B2959; hypothetical protein complement(3036082..3036408) Shigella flexneri 2a str. 2457T 1079425 NP_838452.1 CDS trmB NC_004741.1 3036408 3037127 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(3036408..3037127) Shigella flexneri 2a str. 2457T 1077756 NP_838453.1 CDS mutY NC_004741.1 3037288 3038340 D residues 1 to 350 of 350 are 98.85 pct identical to residues 1 to 350 of 350 from Escherichia coli K-12 : B2961; involved in G.C -->T.A transversions; adenine DNA glycosylase 3037288..3038340 Shigella flexneri 2a str. 2457T 1079426 NP_838454.1 CDS yggX NC_004741.1 3038368 3038643 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from Escherichia coli K-12 : B2962; hypothetical protein 3038368..3038643 Shigella flexneri 2a str. 2457T 1079427 NP_838455.1 CDS mltC NC_004741.1 3038705 3039787 D Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3038705..3039787 Shigella flexneri 2a str. 2457T 1079428 NP_838456.1 CDS nupG NC_004741.1 3039941 3041245 D residues 1 to 434 of 434 are 100.00 pct identical to residues 1 to 434 of 434 from Escherichia coli K-12 : B2964; permease for nucleosides 3039941..3041245 Shigella flexneri 2a str. 2457T 1079429 NP_838457.1 CDS speC NC_004741.1 3041294 3043489 R residues 1 to 731 of 731 are 96.03 pct identical to residues 1 to 731 of 731 from Escherichia coli K-12 : B2965; ornithine decarboxylase complement(3041294..3043489) Shigella flexneri 2a str. 2457T 1079430 NP_838458.1 CDS yqgA NC_004741.1 3043827 3044534 D residues 1 to 235 of 235 are 76.59 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B2966; transporter 3043827..3044534 Shigella flexneri 2a str. 2457T 1079431 NP_838459.1 CDS S4822 NC_004741.1 3044913 3046175 D residues 1 to 420 of 420 are 97.72 pct identical to residues 1 to 420 of 420 from NRprotein_Feb03 : >ref|NP_757064.1| Prophage P4 integrase [Escherichia coli CFT073] gb|AAN83638.1|AE016771_149 Prophage P4 integrase [Escherichia coli CFT073]; P4-type integrase 3044913..3046175 Shigella flexneri 2a str. 2457T 1079433 NP_838460.1 CDS S3169 NC_004741.1 3046628 3050143 D residues 1 to 1171 of 1171 are 92.99 pct identical to residues 1 to 1171 of 1171 from GenPept : >gb|AAL23307.1| (AE008910) superfamily I DNA helicases [Salmonella typhimurium LT2]; superfamily I DNA helicase 3046628..3050143 Shigella flexneri 2a str. 2457T 1079434 NP_838461.1 CDS S4823 NC_004741.1 3051492 3052253 D residues 1 to 253 of 253 are 75.88 pct identical to residues 148 to 400 of 400 from NRprotein_Feb03 : >dbj|BAA77991.1| traF [Plasmid R64] dbj|BAB91674.1| 99 pct identical to gp:AB021078_83[TraF of plasmid ColIb-P9] [Salmonella typhimurium]; hypothetical protein 3051492..3052253 Shigella flexneri 2a str. 2457T 1079390 NP_838462.1 CDS sigA NC_004741.1 3052614 3056471 D residues 1 to 1285 of 1285 are 100.00 pct identical to residues 1 to 1285 of 1285 from NRprotein_Feb03 : >ref|NP_708742.1| exported serine protease SigA [Shigella flexneri 2a str. 301] gb|AAF67320.1|AF200692_1 exported serine protease SigA [Shigella flexneri 2a] gb|AAN44449.1|AE015310_3 exported serine protease SigA [Shigella flexneri 2a str. 301]; serine protease 3052614..3056471 Shigella flexneri 2a str. 2457T 1079436 NP_838463.1 CDS S3177 NC_004741.1 3059545 3059763 D residues 1 to 72 of 72 are 97.22 pct identical to residues 331 to 402 of 402 from GenPept : >gb|AAG18473.1|AF143819_2 (AF143819) transposase-like protein; TnpA [Escherichia coli]; hypothetical protein 3059545..3059763 Shigella flexneri 2a str. 2457T 1079437 NP_838464.1 CDS pic NC_004741.1 3059914 3063126 R residues 1 to 1070 of 1070 are 96.16 pct identical to residues 304 to 1373 of 1373 from GenPept : >gb|AAK00464.1| (AF200692) Pic [Shigella flexneri 2a]; serine protease precurser complement(3059914..3063126) Shigella flexneri 2a str. 2457T 1079438 NP_838465.1 CDS S3180 NC_004741.1 3064760 3065593 R residues 1 to 277 of 277 are 100.00 pct identical to residues 226 to 502 of 502 from GenPept : >dbj|BAA84894.1| (AB024946) orf59 [Escherichia coli]; reverse transcriptase-like protein complement(3064760..3065593) Shigella flexneri 2a str. 2457T 1079439 NP_838466.1 CDS S3181 NC_004741.1 3065587 3066267 R residues 1 to 208 of 226 are 95.19 pct identical to residues 1 to 208 of 376 from GenPept : >gb|AAC73361.1| (AE000133) orf, hypothetical protein [Escherichia coli K12]; reverse transcriptase-like protein complement(3065587..3066267) Shigella flexneri 2a str. 2457T 1079440 NP_838467.1 CDS S3184 NC_004741.1 3067353 3067679 R residues 1 to 108 of 108 are 74.07 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL67399.1|AF447814_67 (AF447814) TnpE-like protein [Escherichia coli]; IS629 orfA complement(3067353..3067679) Shigella flexneri 2a str. 2457T 1079441 NP_838468.1 CDS S3185 NC_004741.1 3067962 3068387 R residues 15 to 119 of 141 are 37.27 pct identical to residues 44 to 153 of 173 from GenPept : >gb|AAL08463.1|AF326777_38 (AF326777) unknown [Shigella flexneri 2a]; hypothetical protein complement(3067962..3068387) Shigella flexneri 2a str. 2457T 1079442 NP_838469.1 CDS S3186 NC_004741.1 3068384 3068767 R residues 1 to 127 of 127 are 100.00 pct identical to residues 1 to 127 of 127 from GenPept : >gb|AAK00467.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein complement(3068384..3068767) Shigella flexneri 2a str. 2457T 1079443 NP_838470.1 CDS S3187 NC_004741.1 3069140 3069739 R residues 80 to 199 of 199 are 100.00 pct identical to residues 1 to 120 of 120 from GenPept : >gb|AAK00468.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein complement(3069140..3069739) Shigella flexneri 2a str. 2457T 1079444 NP_838471.2 CDS S3188 NC_004741.1 3070456 3070821 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3070456..3070821 Shigella flexneri 2a str. 2457T 1079445 NP_838472.2 CDS S3189 NC_004741.1 3070779 3071684 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3070779..3071684 Shigella flexneri 2a str. 2457T 1079446 NP_838473.1 CDS S3190 NC_004741.1 3073538 3073744 D residues 1 to 68 of 68 are 89.70 pct identical to residues 25 to 92 of 92 from GenPept : >gb|AAL08466.1| (AF326777) unknown [Shigella flexneri 2a]; hypothetical protein 3073538..3073744 Shigella flexneri 2a str. 2457T 1079447 NP_838474.1 CDS S3191 NC_004741.1 3073830 3074402 D residues 19 to 190 of 190 are 92.44 pct identical to residues 1 to 172 of 172 from GenPept : >gb|AAK00471.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein 3073830..3074402 Shigella flexneri 2a str. 2457T 1079448 NP_838475.1 CDS S4825 NC_004741.1 3074404 3074688 R no significant similarities; hypothetical protein complement(3074404..3074688) Shigella flexneri 2a str. 2457T 1079449 NP_838476.1 CDS S4826 NC_004741.1 3075971 3076990 D residues 1 to 339 of 339 are 100.00 pct identical to residues 1 to 339 of 339 from NRprotein_Feb03 : >ref|NP_708763.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN44470.1|AE015312_3 orf, conserved hypothetical protein [Shigella flexneri 2a str. 301]; hypothetical protein 3075971..3076990 Shigella flexneri 2a str. 2457T 1079450 NP_838477.1 CDS sap NC_004741.1 3077100 3077972 D residues 1 to 290 of 290 are 99.65 pct identical to residues 1 to 290 of 290 from GenPept : >gb|AAK00473.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein 3077100..3077972 Shigella flexneri 2a str. 2457T 1079451 NP_838478.1 CDS S3194 NC_004741.1 3078306 3079199 D residues 1 to 293 of 297 are 64.16 pct identical to residues 53 to 344 of 1091 from Escherichia coli K-12 : B2000; similar to adhesin; outer membrane fluffing protein 3078306..3079199 Shigella flexneri 2a str. 2457T 1079452 NP_838479.1 CDS S3195 NC_004741.1 3079305 3081425 D residues 1 to 706 of 706 are 92.77 pct identical to residues 386 to 1091 of 1091 from Escherichia coli K-12 : B2000; similar to adhesin; outer membrane fluffing protein 3079305..3081425 Shigella flexneri 2a str. 2457T 1079668 NP_838480.1 CDS S3196 NC_004741.1 3081546 3084062 D residues 1 to 507 of 838 are 85.99 pct identical to residues 3 to 509 of 512 from Escherichia coli K-12 : B2001; hypothetical protein 3081546..3084062 Shigella flexneri 2a str. 2457T 1076492 NP_838481.1 CDS S3197 NC_004741.1 3084138 3084593 D residues 9 to 151 of 151 are 99.30 pct identical to residues 1 to 143 of 143 from GenPept : >gb|AAK00476.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein 3084138..3084593 Shigella flexneri 2a str. 2457T 1079453 NP_838482.1 CDS S3199 NC_004741.1 3085004 3085822 D residues 1 to 272 of 272 are 89.37 pct identical to residues 1 to 273 of 273 from GenPept : >dbj|BAB36224.1| (AP002559) hypothetical protein [Escherichia coli O157:H7]; hypothetical protein 3085004..3085822 Shigella flexneri 2a str. 2457T 1079454 NP_838483.1 CDS S3200 NC_004741.1 3086164 3086637 D residues 1 to 157 of 157 are 99.36 pct identical to residues 115 to 271 of 271 from GenPept : >gb|AAK00478.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein 3086164..3086637 Shigella flexneri 2a str. 2457T 1079455 NP_838484.1 CDS yeeS NC_004741.1 3086638 3087129 D residues 16 to 163 of 163 are 85.81 pct identical to residues 1 to 148 of 148 from Escherichia coli K-12 : B2002; RADC family DNA repair protein 3086638..3087129 Shigella flexneri 2a str. 2457T 1079456 NP_838485.1 CDS yeeT NC_004741.1 3087216 3087437 D residues 1 to 73 of 73 are 93.15 pct identical to residues 1 to 73 of 73 from Escherichia coli K-12 : B2003; hypothetical protein 3087216..3087437 Shigella flexneri 2a str. 2457T 1079457 NP_838486.1 CDS yeeU NC_004741.1 3087517 3087894 D residues 1 to 107 of 125 are 94.39 pct identical to residues 1 to 107 of 122 from Escherichia coli K-12 : B2004; structural protein 3087517..3087894 Shigella flexneri 2a str. 2457T 1079458 NP_838487.1 CDS yeeV NC_004741.1 3087941 3088318 D residues 1 to 124 of 125 are 85.48 pct identical to residues 1 to 124 of 124 from Escherichia coli K-12 : B2005; hypothetical protein 3087941..3088318 Shigella flexneri 2a str. 2457T 1079459 NP_838488.1 CDS yeeW NC_004741.1 3088315 3088803 D residues 5 to 52 of 162 are 79.16 pct identical to residues 2 to 49 of 64 from Escherichia coli K-12 : B2006; hypothetical protein 3088315..3088803 Shigella flexneri 2a str. 2457T 1079460 NP_838489.1 CDS S3207 NC_004741.1 3089105 3089947 D residues 1 to 280 of 280 are 100.00 pct identical to residues 1 to 280 of 280 from GenPept : >gb|AAK00485.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein 3089105..3089947 Shigella flexneri 2a str. 2457T 1079463 NP_838490.1 CDS S3209 NC_004741.1 3091372 3091671 D residues 1 to 99 of 99 are 100.00 pct identical to residues 1 to 99 of 99 from GenPept : >gb|AAL57580.1|AF453442_9 (AF453442) transposase 2 [Escherichia coli]; IS3 orfA 3091372..3091671 Shigella flexneri 2a str. 2457T 1079464 NP_838491.1 CDS S3210 NC_004741.1 3091668 3092534 D residues 1 to 288 of 288 are 99.30 pct identical to residues 1 to 288 of 288 from GenPept : >gb|AAL57519.1|AF453441_3 (AF453441) transposase 1 [Escherichia coli]; IS3 orfB 3091668..3092534 Shigella flexneri 2a str. 2457T 1079465 NP_838492.1 CDS S3211 NC_004741.1 3093171 3093410 R no significant similarities; hypothetical protein complement(3093171..3093410) Shigella flexneri 2a str. 2457T 1079466 NP_838493.1 CDS S3212 NC_004741.1 3093545 3094150 R no significant similarities; hypothetical protein complement(3093545..3094150) Shigella flexneri 2a str. 2457T 1079467 NP_838494.1 CDS S3213 NC_004741.1 3094265 3094768 R residues 3 to 97 of 97 are 83.15 pct identical to residues 73 to 167 of 167 from GenPept : >gb|AAK18549.1|AF348706_238 (AF348706) iso-IS1 orfB [Shigella flexneri]; IS1 orfB complement(3094265..3094768) Shigella flexneri 2a str. 2457T 1076474 NP_838495.1 CDS S3214 NC_004741.1 3094687 3094962 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3094687..3094962) Shigella flexneri 2a str. 2457T 1079468 NP_838496.1 CDS yghK NC_004741.1 3096365 3097951 R residues 1 to 528 of 528 are 79.82 pct identical to residues 1 to 560 of 560 from Escherichia coli K-12 : B2975; permease complement(3096365..3097951) Shigella flexneri 2a str. 2457T 1079470 NP_838497.1 CDS glcB NC_004741.1 3098306 3100477 R catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G complement(3098306..3100477) Shigella flexneri 2a str. 2457T 1079471 NP_838498.1 CDS glcG NC_004741.1 3100499 3100903 R residues 1 to 118 of 134 are 100.00 pct identical to residues 1 to 118 of 134 from Escherichia coli K-12 : B2977; hypothetical protein complement(3100499..3100903) Shigella flexneri 2a str. 2457T 1079472 NP_838499.1 CDS glcC NC_004741.1 3104940 3105710 D residues 1 to 252 of 256 are 98.41 pct identical to residues 1 to 252 of 254 from Escherichia coli K-12 : B2980; DNA-binding transcriptional regulator GlcC 3104940..3105710 Shigella flexneri 2a str. 2457T 1079476 NP_838500.1 CDS S3222 NC_004741.1 3107379 3109067 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3107379..3109067 Shigella flexneri 2a str. 2457T 1079478 NP_838501.1 CDS S3223 NC_004741.1 3109082 3109978 D residues 1 to 281 of 298 are 32.74 pct identical to residues 11 to 288 of 317 from GenPept : >gb|AAK23148.1| (AE005794) conserved hypothetical protein [Caulobacter crescentus CB15]; hypothetical protein 3109082..3109978 Shigella flexneri 2a str. 2457T 1080726 NP_838502.1 CDS S3224 NC_004741.1 3110011 3110259 D no significant similarities; hypothetical protein 3110011..3110259 Shigella flexneri 2a str. 2457T 1079479 NP_838503.1 CDS S3225 NC_004741.1 3110259 3110609 D residues 1 to 109 of 116 are 41.28 pct identical to residues 1 to 109 of 404 from GenPept : >gb|AAK23146.1| (AE005794) aminotransferase, class II [Caulobacter crescentus CB15]; partial; class II aminotransferase 3110259..3110609 Shigella flexneri 2a str. 2457T 1079486 NP_838504.1 CDS S3226 NC_004741.1 3110642 3111430 D residues 2 to 260 of 262 are 51.53 pct identical to residues 130 to 389 of 404 from GenPept : >gb|AAK23146.1| (AE005794) aminotransferase, class II [Caulobacter crescentus CB15]; partial; class II aminotransferase 3110642..3111430 Shigella flexneri 2a str. 2457T 1079480 NP_838505.1 CDS S3227 NC_004741.1 3111466 3112545 R residues 3 to 352 of 359 are 28.61 pct identical to residues 4 to 354 of 358 from GenPept : >emb|CAC92669.1| (AJ414157) membrane protein [Yersinia pestis]; hypothetical protein complement(3111466..3112545) Shigella flexneri 2a str. 2457T 1079482 NP_838506.1 CDS S3228 NC_004741.1 3112542 3113612 R residues 34 to 342 of 356 are 28.66 pct identical to residues 33 to 350 of 372 from GenPept : >gb|AAG07215.1|AE004800_4 (AE004800) conserved hypothetical protein [Pseudomonas aeruginosa]; hypothetical protein complement(3112542..3113612) Shigella flexneri 2a str. 2457T 1079484 NP_838507.1 CDS S3229 NC_004741.1 3113643 3114203 R residues 20 to 184 of 186 are 56.36 pct identical to residues 20 to 183 of 184 from GenPept : >gb|AAL01384.1|AF407017_1 (AF407017) periplasmic protein [Escherichia coli]; hypothetical protein complement(3113643..3114203) Shigella flexneri 2a str. 2457T 1076473 NP_838508.1 CDS S3230 NC_004741.1 3114215 3115039 R no significant similarities; hypothetical protein complement(3114215..3115039) Shigella flexneri 2a str. 2457T 1079485 NP_838509.1 CDS yghQ NC_004741.1 3115039 3116388 R residues 45 to 355 of 449 are 92.92 pct identical to residues 15 to 325 of 325 from Escherichia coli K-12 : B2983; hypothetical protein complement(3115039..3116388) Shigella flexneri 2a str. 2457T 1078248 NP_838510.1 CDS yghR NC_004741.1 3116434 3117192 R residues 1 to 252 of 252 are 92.85 pct identical to residues 1 to 252 of 252 from Escherichia coli K-12 : B2984; hypothetical protein complement(3116434..3117192) Shigella flexneri 2a str. 2457T 1079487 NP_838511.1 CDS yghS NC_004741.1 3117224 3117937 R residues 1 to 237 of 237 are 97.46 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B2985; hypothetical protein complement(3117224..3117937) Shigella flexneri 2a str. 2457T 1079549 NP_838512.1 CDS yghT NC_004741.1 3118111 3118803 D residues 1 to 230 of 230 are 99.56 pct identical to residues 1 to 230 of 230 from Escherichia coli K-12 : B2986; hypothetical protein 3118111..3118803 Shigella flexneri 2a str. 2457T 1079488 NP_838513.1 CDS pitB NC_004741.1 3118852 3120351 R residues 1 to 499 of 499 are 89.17 pct identical to residues 1 to 499 of 499 from Escherichia coli K-12 : B2987; low-affinity phosphate transport protein complement(3118852..3120351) Shigella flexneri 2a str. 2457T 1079489 NP_838514.1 CDS gsp NC_004741.1 3120643 3122502 R catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase complement(3120643..3122502) Shigella flexneri 2a str. 2457T 1079490 NP_838515.1 CDS S3237 NC_004741.1 3122659 3123573 D YghU; B2989; one of eight glutathione transferase proteins from E. coli; glutathione S-transferase 3122659..3123573 Shigella flexneri 2a str. 2457T 1079491 NP_838516.1 CDS hybG NC_004741.1 3123696 3123944 R residues 1 to 82 of 82 are 100.00 pct identical to residues 1 to 82 of 82 from Escherichia coli K-12 : B2990; may effect maturation of large subunit of hydrogenase-2; hydrogenase 2 accessory protein HypG complement(3123696..3123944) Shigella flexneri 2a str. 2457T 1079492 NP_838517.1 CDS hypA NC_004741.1 3124078 3124419 R plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF complement(3124078..3124419) Shigella flexneri 2a str. 2457T 1079493 NP_838518.1 CDS hybE NC_004741.1 3124412 3124900 R residues 1 to 162 of 162 are 91.97 pct identical to residues 1 to 162 of 162 from Escherichia coli K-12 : B2992; hydrogenase 2-specific chaperone complement(3124412..3124900) Shigella flexneri 2a str. 2457T 1079494 NP_838519.1 CDS hybD NC_004741.1 3124893 3125387 R protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase complement(3124893..3125387) Shigella flexneri 2a str. 2457T 1079495 NP_838520.1 CDS hybC NC_004741.1 3125387 3127090 R involved in hydrogen uptake; hydrogenase 2 large subunit complement(3125387..3127090) Shigella flexneri 2a str. 2457T 1079496 NP_838521.1 CDS hybB NC_004741.1 3127087 3128265 R HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit complement(3127087..3128265) Shigella flexneri 2a str. 2457T 1079497 NP_838522.1 CDS hybA NC_004741.1 3128255 3129241 R Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA complement(3128255..3129241) Shigella flexneri 2a str. 2457T 1079498 NP_838523.1 CDS S3245 NC_004741.1 3129244 3130362 R involved in hydrogen uptake; hydrogenase 2 small subunit complement(3129244..3130362) Shigella flexneri 2a str. 2457T 1079503 NP_838524.1 CDS S3246 NC_004741.1 3130551 3130838 R residues 1 to 95 of 95 are 100.00 pct identical to residues 1 to 95 of 95 from Escherichia coli K-12 : B2998; hypothetical protein complement(3130551..3130838) Shigella flexneri 2a str. 2457T 1079499 NP_838525.1 CDS S3247 NC_004741.1 3130957 3131367 R residues 1 to 136 of 136 are 98.52 pct identical to residues 1 to 136 of 136 from Escherichia coli K-12 : B2999; hypothetical protein complement(3130957..3131367) Shigella flexneri 2a str. 2457T 1079500 NP_838526.1 CDS S3249 NC_004741.1 3132001 3133041 D residues 1 to 346 of 346 are 99.42 pct identical to residues 1 to 346 of 346 from Escherichia coli K-12 : B3001; aldo-keto reductase 3132001..3133041 Shigella flexneri 2a str. 2457T 1079502 NP_838527.1 CDS yqhA NC_004741.1 3133081 3133575 R residues 1 to 164 of 164 are 92.07 pct identical to residues 1 to 164 of 164 from Escherichia coli K-12 : B3002; hypothetical protein complement(3133081..3133575) Shigella flexneri 2a str. 2457T 1079504 NP_838528.1 CDS yghA NC_004741.1 3133766 3134650 D residues 1 to 294 of 294 are 93.87 pct identical to residues 1 to 294 of 294 from Escherichia coli K-12 : B3003; oxidoreductase 3133766..3134650 Shigella flexneri 2a str. 2457T 1079505 NP_838529.1 CDS S3252 NC_004741.1 3134826 3135071 D residues 1 to 81 of 81 are 100.00 pct identical to residues 1 to 81 of 81 from Escherichia coli K-12 : B3004; hypothetical protein 3134826..3135071 Shigella flexneri 2a str. 2457T 1079506 NP_838530.1 CDS exbD NC_004741.1 3134922 3135347 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD complement(3134922..3135347) Shigella flexneri 2a str. 2457T 1079507 NP_838531.1 CDS exbB NC_004741.1 3135354 3136088 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB complement(3135354..3136088) Shigella flexneri 2a str. 2457T 1080948 NP_838532.1 CDS S3255 NC_004741.1 3136081 3136236 R residues 1 to 51 of 51 are 100.00 pct identical to residues 1 to 51 of 51 from Escherichia coli K-12 : B3007; hypothetical protein complement(3136081..3136236) Shigella flexneri 2a str. 2457T 1079508 NP_838533.1 CDS metC NC_004741.1 3136340 3137527 D catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3136340..3137527 Shigella flexneri 2a str. 2457T 1079509 NP_838534.1 CDS yghB NC_004741.1 3137667 3138326 D residues 1 to 219 of 219 are 84.01 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B3009; hypothetical protein 3137667..3138326 Shigella flexneri 2a str. 2457T 1079510 NP_838535.1 CDS yqhC NC_004741.1 3138366 3139493 R residues 1 to 375 of 375 are 99.73 pct identical to residues 1 to 375 of 375 from Escherichia coli K-12 : B3010; ARAC-type regulatory protein complement(3138366..3139493) Shigella flexneri 2a str. 2457T 1079512 NP_838536.1 CDS yqhD NC_004741.1 3139459 3140622 D residues 1 to 387 of 387 are 99.48 pct identical to residues 1 to 387 of 387 from Escherichia coli K-12 : B3011; oxidoreductase 3139459..3140622 Shigella flexneri 2a str. 2457T 1079513 NP_838537.2 CDS dkgA NC_004741.1 3140727 3141554 D methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3140727..3141554 Shigella flexneri 2a str. 2457T 1077738 NP_838538.1 CDS yqhG NC_004741.1 3141754 3142680 D residues 1 to 308 of 308 are 95.46 pct identical to residues 1 to 309 of 309 from Escherichia coli K-12 : B3013; hypothetical protein 3141754..3142680 Shigella flexneri 2a str. 2457T 1077754 NP_838539.1 CDS yqhH NC_004741.1 3142731 3142988 D residues 1 to 85 of 85 are 100.00 pct identical to residues 1 to 85 of 85 from Escherichia coli K-12 : B3014; outer membrane lipoprotein 3142731..3142988 Shigella flexneri 2a str. 2457T 1079514 NP_838540.1 CDS S3263 NC_004741.1 3143031 3144272 R residues 1 to 413 of 413 are 99.51 pct identical to residues 1 to 413 of 413 from Escherichia coli K-12 : B3015; hypothetical protein complement(3143031..3144272) Shigella flexneri 2a str. 2457T 1079515 NP_838541.1 CDS sufI NC_004741.1 3145361 3146773 R residues 1 to 470 of 470 are 92.34 pct identical to residues 1 to 470 of 470 from Escherichia coli K-12 : B3017; repressor protein for FtsI complement(3145361..3146773) Shigella flexneri 2a str. 2457T 1079517 NP_838542.1 CDS plsC NC_004741.1 3146848 3147585 R residues 1 to 245 of 245 are 94.69 pct identical to residues 1 to 245 of 245 from Escherichia coli K-12 : B3018; 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(3146848..3147585) Shigella flexneri 2a str. 2457T 1079518 NP_838543.1 CDS parC NC_004741.1 3147819 3150077 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A complement(3147819..3150077) Shigella flexneri 2a str. 2457T 1076484 NP_838544.1 CDS S3268 NC_004741.1 3150623 3151105 R residues 1 to 160 of 160 are 97.50 pct identical to residues 1 to 160 of 160 from Escherichia coli K-12 : B3023; hypothetical protein complement(3150623..3151105) Shigella flexneri 2a str. 2457T 1079521 NP_838545.1 CDS ygiW NC_004741.1 3151158 3151550 R residues 1 to 130 of 130 are 99.23 pct identical to residues 1 to 130 of 130 from Escherichia coli K-12 : B3024; hypothetical protein complement(3151158..3151550) Shigella flexneri 2a str. 2457T 1077781 NP_838546.1 CDS ygiX NC_004741.1 3151702 3152361 D response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3151702..3152361 Shigella flexneri 2a str. 2457T 1077766 NP_838547.1 CDS ygiY NC_004741.1 3152358 3153632 D residues 1 to 424 of 424 are 89.08 pct identical to residues 1 to 449 of 449 from Escherichia coli K-12 : B3026; sensor protein QseC 3152358..3153632 Shigella flexneri 2a str. 2457T 1079522 NP_838548.1 CDS S3272 NC_004741.1 3153678 3154010 R residues 1 to 110 of 110 are 86.36 pct identical to residues 1 to 110 of 110 from Escherichia coli K-12 : B3027; hypothetical protein complement(3153678..3154010) Shigella flexneri 2a str. 2457T 1079525 NP_838549.1 CDS mdaB NC_004741.1 3154329 3154910 D residues 1 to 193 of 193 are 98.44 pct identical to residues 1 to 193 of 193 from Escherichia coli K-12 : B3028; modulator of drug activity B 3154329..3154910 Shigella flexneri 2a str. 2457T 1079526 NP_838550.1 CDS ygiN NC_004741.1 3154941 3155255 D residues 1 to 104 of 104 are 100.00 pct identical to residues 1 to 104 of 104 from Escherichia coli K-12 : B3029; hypothetical protein 3154941..3155255 Shigella flexneri 2a str. 2457T 1079527 NP_838551.1 CDS parE NC_004741.1 3155303 3157195 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B complement(3155303..3157195) Shigella flexneri 2a str. 2457T 1079528 NP_838552.1 CDS yqiA NC_004741.1 3157224 3157805 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA complement(3157224..3157805) Shigella flexneri 2a str. 2457T 1079529 NP_838553.1 CDS icc NC_004741.1 3157805 3158632 R residues 1 to 275 of 275 are 95.99 pct identical to residues 1 to 275 of 275 from Escherichia coli K-12 : B3032; cyclic 3',5'-adenosine monophosphate phosphodiesterase complement(3157805..3158632) Shigella flexneri 2a str. 2457T 1077772 NP_838554.1 CDS yqiB NC_004741.1 3158657 3159079 R residues 1 to 140 of 140 are 100.00 pct identical to residues 1 to 140 of 140 from Escherichia coli K-12 : B3033; hypothetical protein complement(3158657..3159079) Shigella flexneri 2a str. 2457T 1079530 NP_838555.1 CDS nudF NC_004741.1 3159080 3159709 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase NudF complement(3159080..3159709) Shigella flexneri 2a str. 2457T 1080971 NP_838556.1 CDS tolC NC_004741.1 3159914 3161395 D trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3159914..3161395 Shigella flexneri 2a str. 2457T 1080970 NP_838557.1 CDS ygiA NC_004741.1 3161395 3161655 D residues 1 to 86 of 86 are 100.00 pct identical to residues 1 to 86 of 86 from Escherichia coli K-12 : B3036; hypothetical protein 3161395..3161655 Shigella flexneri 2a str. 2457T 1080969 NP_838558.2 CDS ygiB NC_004741.1 3161543 3162214 D residues 1 to 234 of 234 are 92.30 pct identical to residues 1 to 234 of 234 from Escherichia coli K-12 : B3037; hypothetical protein 3161543..3162214 Shigella flexneri 2a str. 2457T 1079531 NP_838559.1 CDS ygiC NC_004741.1 3162220 3163380 D residues 1 to 386 of 386 are 99.74 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 : B3038; synthetase/amidase 3162220..3163380 Shigella flexneri 2a str. 2457T 1079532 NP_838560.1 CDS ygiD NC_004741.1 3163418 3164233 R seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein complement(3163418..3164233) Shigella flexneri 2a str. 2457T 1079533 NP_838561.1 CDS ygiE NC_004741.1 3164349 3165122 D residues 1 to 257 of 257 are 88.71 pct identical to residues 1 to 257 of 257 from Escherichia coli K-12 : B3040; zinc transporter ZupT 3164349..3165122 Shigella flexneri 2a str. 2457T 1077767 NP_838562.1 CDS ribB NC_004741.1 3165611 3166264 R DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(3165611..3166264) Shigella flexneri 2a str. 2457T 1079534 NP_838563.1 CDS S3287 NC_004741.1 3166578 3166928 D residues 1 to 116 of 116 are 99.13 pct identical to residues 1 to 116 of 116 from Escherichia coli K-12 : B3042; hypothetical protein 3166578..3166928 Shigella flexneri 2a str. 2457T 1079535 NP_838564.2 CDS S3288 NC_004741.1 3167184 3167549 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3167184..3167549 Shigella flexneri 2a str. 2457T 1079536 NP_838565.2 CDS S3289 NC_004741.1 3167507 3168358 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfB protein 3167507..3168358 Shigella flexneri 2a str. 2457T 1079537 NP_838566.1 CDS S3290 NC_004741.1 3168409 3168684 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3168409..3168684 Shigella flexneri 2a str. 2457T 1080975 NP_838567.1 CDS S3291 NC_004741.1 3168603 3169106 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3168603..3169106 Shigella flexneri 2a str. 2457T 1079538 NP_838568.1 CDS S3292 NC_004741.1 3169116 3169391 D residues 1 to 91 of 91 are 97.80 pct identical to residues 358 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 3169116..3169391 Shigella flexneri 2a str. 2457T 1079539 NP_838569.1 CDS glgS NC_004741.1 3169778 3169978 R Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS complement(3169778..3169978) Shigella flexneri 2a str. 2457T 1077783 NP_838570.1 CDS S3295 NC_004741.1 3170300 3170599 D residues 1 to 85 of 99 are 100.00 pct identical to residues 1 to 85 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3170300..3170599 Shigella flexneri 2a str. 2457T 1078323 NP_838571.1 CDS S3298 NC_004741.1 3173108 3174541 R catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(3173108..3174541) Shigella flexneri 2a str. 2457T 1079582 NP_838572.1 CDS glnE NC_004741.1 3174589 3177429 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(3174589..3177429) Shigella flexneri 2a str. 2457T 1079543 NP_838573.1 CDS ygiF NC_004741.1 3177452 3178753 R residues 1 to 433 of 433 are 93.53 pct identical to residues 1 to 433 of 433 from Escherichia coli K-12 : B3054; hypothetical protein complement(3177452..3178753) Shigella flexneri 2a str. 2457T 1079544 NP_838574.1 CDS ygiM NC_004741.1 3178995 3179615 D residues 1 to 206 of 206 are 87.37 pct identical to residues 1 to 206 of 206 from Escherichia coli K-12 : B3055; signal transduction protein 3178995..3179615 Shigella flexneri 2a str. 2457T 1079545 NP_838575.1 CDS cca NC_004741.1 3179679 3180917 D catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3179679..3180917 Shigella flexneri 2a str. 2457T 1078289 NP_838576.1 CDS uppP NC_004741.1 3181079 3181900 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase complement(3181079..3181900) Shigella flexneri 2a str. 2457T 1079546 NP_838577.1 CDS folB NC_004741.1 3181991 3182359 R catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase complement(3181991..3182359) Shigella flexneri 2a str. 2457T 1076577 NP_838578.1 CDS ygiH NC_004741.1 3182464 3183081 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 3182464..3183081 Shigella flexneri 2a str. 2457T 1079547 NP_838579.1 CDS ygiP NC_004741.1 3183024 3184025 R activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR complement(3183024..3184025) Shigella flexneri 2a str. 2457T 1078105 NP_838580.1 CDS ttdA NC_004741.1 3184235 3185044 D Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3184235..3185044 Shigella flexneri 2a str. 2457T 1079550 NP_838581.1 CDS ttdB NC_004741.1 3185072 3185677 D Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3185072..3185677 Shigella flexneri 2a str. 2457T 1079551 NP_838582.1 CDS ygjE NC_004741.1 3185725 3187188 D residues 1 to 487 of 487 are 82.95 pct identical to residues 1 to 487 of 487 from Escherichia coli K-12 : B3063; hypothetical protein 3185725..3187188 Shigella flexneri 2a str. 2457T 1079552 NP_838583.1 CDS ygjD NC_004741.1 3187231 3188244 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease complement(3187231..3188244) Shigella flexneri 2a str. 2457T 1079554 NP_838584.1 CDS rpsU NC_004741.1 3188482 3188697 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3188482..3188697 Shigella flexneri 2a str. 2457T 1079555 NP_838585.1 CDS dnaG NC_004741.1 3188808 3190553 D synthesizes RNA primers at the replication forks; DNA primase 3188808..3190553 Shigella flexneri 2a str. 2457T 1079556 NP_838586.1 CDS rpoD NC_004741.1 3190748 3192574 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3190748..3192574 Shigella flexneri 2a str. 2457T 1079047 NP_838587.1 CDS S3314 NC_004741.1 3192746 3194074 D residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 3192746..3194074 Shigella flexneri 2a str. 2457T 1079638 NP_838588.1 CDS yqjI NC_004741.1 3195888 3196511 D residues 1 to 207 of 207 are 83.09 pct identical to residues 1 to 207 of 207 from Escherichia coli K-12 : B3071; hypothetical protein 3195888..3196511 Shigella flexneri 2a str. 2457T 1079560 NP_838589.2 CDS ygjG NC_004741.1 3198576 3199982 D catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3198576..3199982 Shigella flexneri 2a str. 2457T 1077735 NP_838590.1 CDS ebgR NC_004741.1 3200573 3201556 D residues 1 to 327 of 327 are 99.38 pct identical to residues 1 to 327 of 327 from Escherichia coli K-12 : B3075; DNA-binding transcriptional repressor EbgR 3200573..3201556 Shigella flexneri 2a str. 2457T 1079563 NP_838591.1 CDS ebgA NC_004741.1 3201739 3204825 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3201739..3204825 Shigella flexneri 2a str. 2457T 1079564 NP_838592.1 CDS ebgC NC_004741.1 3204822 3205271 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3204822..3205271 Shigella flexneri 2a str. 2457T 1079565 NP_838593.1 CDS ygjI NC_004741.1 3205334 3206767 D residues 1 to 477 of 477 are 92.03 pct identical to residues 1 to 477 of 477 from Escherichia coli K-12 : B3078; oxidoreductase 3205334..3206767 Shigella flexneri 2a str. 2457T 1079566 NP_838594.1 CDS ygjK NC_004741.1 3207989 3210340 D residues 1 to 783 of 783 are 95.65 pct identical to residues 1 to 783 of 783 from Escherichia coli K-12 : B3080; glycosyl hydrolase 3207989..3210340 Shigella flexneri 2a str. 2457T 1079567 NP_838595.1 CDS ygjL NC_004741.1 3210566 3212584 D residues 1 to 672 of 672 are 95.23 pct identical to residues 1 to 672 of 672 from Escherichia coli K-12 : B3081; NADPH dehydrogenase 3210566..3212584 Shigella flexneri 2a str. 2457T 1079568 NP_838596.1 CDS ygjM NC_004741.1 3212629 3213045 R residues 1 to 138 of 138 are 90.57 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 : B3082; hypothetical protein complement(3212629..3213045) Shigella flexneri 2a str. 2457T 1077095 NP_838597.1 CDS ygjN NC_004741.1 3213042 3213356 R residues 1 to 104 of 104 are 100.00 pct identical to residues 1 to 104 of 104 from Escherichia coli K-12 : B3083; hypothetical protein complement(3213042..3213356) Shigella flexneri 2a str. 2457T 1079569 NP_838598.1 CDS ygjO NC_004741.1 3213641 3214777 R residues 1 to 378 of 378 are 95.76 pct identical to residues 11 to 388 of 388 from Escherichia coli K-12 : B3084; enzyme complement(3213641..3214777) Shigella flexneri 2a str. 2457T 1078756 NP_838599.1 CDS ygjP NC_004741.1 3214826 3215365 D residues 1 to 179 of 179 are 98.32 pct identical to residues 1 to 179 of 179 from Escherichia coli K-12 : B3085; hypothetical protein 3214826..3215365 Shigella flexneri 2a str. 2457T 1079570 NP_838600.1 CDS ygjQ NC_004741.1 3215442 3216134 D residues 1 to 230 of 230 are 97.82 pct identical to residues 1 to 230 of 230 from Escherichia coli K-12 : B3086; hypothetical protein 3215442..3216134 Shigella flexneri 2a str. 2457T 1079571 NP_838601.1 CDS ygjR NC_004741.1 3216195 3217211 D residues 1 to 334 of 338 are 98.80 pct identical to residues 1 to 334 of 334 from Escherichia coli K-12 : B3087; hypothetical protein 3216195..3217211 Shigella flexneri 2a str. 2457T 1079572 NP_838602.1 CDS ygjT NC_004741.1 3217482 3218447 D residues 1 to 320 of 321 are 97.52 pct identical to residues 1 to 320 of 321 from Escherichia coli K-12 : B3088; transporter 3217482..3218447 Shigella flexneri 2a str. 2457T 1079573 NP_838603.1 CDS ygjU NC_004741.1 3219032 3220276 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3219032..3220276 Shigella flexneri 2a str. 2457T 1079574 NP_838604.1 CDS ygjV NC_004741.1 3220281 3220832 R residues 1 to 183 of 183 are 98.36 pct identical to residues 1 to 183 of 183 from Escherichia coli K-12 : B3090; hypothetical protein complement(3220281..3220832) Shigella flexneri 2a str. 2457T 1079575 NP_838605.1 CDS uxaA NC_004741.1 3220915 3222402 R residues 1 to 495 of 495 are 96.76 pct identical to residues 1 to 495 of 495 from Escherichia coli K-12 : B3091; altronate hydrolase complement(3220915..3222402) Shigella flexneri 2a str. 2457T 1079576 NP_838606.1 CDS uxaC NC_004741.1 3222417 3223829 R catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase complement(3222417..3223829) Shigella flexneri 2a str. 2457T 1079577 NP_838607.1 CDS exuT NC_004741.1 3224314 3225612 D residues 1 to 432 of 432 are 89.58 pct identical to residues 41 to 472 of 472 from Escherichia coli K-12 : B3093; transport protein of hexuronates 3224314..3225612 Shigella flexneri 2a str. 2457T 1079578 NP_838608.1 CDS S3341 NC_004741.1 3225700 3226332 R residues 1 to 200 of 210 are 33.81 pct identical to residues 161 to 350 of 359 from GenPept : >emb|CAD08773.1| (AL627266) fimbrail protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(3225700..3226332) Shigella flexneri 2a str. 2457T 1079580 NP_838609.1 CDS S3342 NC_004741.1 3226785 3228776 R residues 1 to 645 of 663 are 31.39 pct identical to residues 237 to 878 of 895 from GenPept : >emb|CAD08772.1| (AL627266) outer membrane fimbrial user protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(3226785..3228776) Shigella flexneri 2a str. 2457T 1079581 NP_838610.1 CDS S3343 NC_004741.1 3228942 3229217 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3228942..3229217 Shigella flexneri 2a str. 2457T 1079583 NP_838611.1 CDS S3344 NC_004741.1 3229136 3229639 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3229136..3229639 Shigella flexneri 2a str. 2457T 1079584 NP_838612.1 CDS exuR NC_004741.1 3229747 3230523 D regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3229747..3230523 Shigella flexneri 2a str. 2457T 1079595 NP_838613.1 CDS yqjA NC_004741.1 3230868 3231530 D residues 15 to 220 of 220 are 100.00 pct identical to residues 15 to 220 of 220 from Escherichia coli K-12 : B3095; hypothetical protein 3230868..3231530 Shigella flexneri 2a str. 2457T 1079585 NP_838614.1 CDS yqjB NC_004741.1 3231549 3231917 D residues 1 to 122 of 122 are 85.24 pct identical to residues 6 to 127 of 127 from Escherichia coli K-12 : B3096; hypothetical protein 3231549..3231917 Shigella flexneri 2a str. 2457T 1079586 NP_838615.1 CDS yqjD NC_004741.1 3232456 3232761 D residues 1 to 82 of 101 are 78.04 pct identical to residues 1 to 82 of 101 from Escherichia coli K-12 : B3098; hypothetical protein 3232456..3232761 Shigella flexneri 2a str. 2457T 1079588 NP_838616.1 CDS yqjE NC_004741.1 3232764 3233168 D residues 1 to 134 of 134 are 67.16 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B3099; hypothetical protein 3232764..3233168 Shigella flexneri 2a str. 2457T 1079589 NP_838617.1 CDS S3351 NC_004741.1 3233158 3233457 D residues 1 to 99 of 99 are 95.95 pct identical to residues 1 to 99 of 99 from Escherichia coli K-12 : B3100; hypothetical protein 3233158..3233457 Shigella flexneri 2a str. 2457T 1079590 NP_838618.1 CDS yqjG NC_004741.1 3234009 3234995 D residues 1 to 328 of 328 are 95.42 pct identical to residues 1 to 328 of 328 from Escherichia coli K-12 : B3102; transferase 3234009..3234995 Shigella flexneri 2a str. 2457T 1079592 NP_838619.1 CDS yhaH NC_004741.1 3235288 3235656 D residues 1 to 120 of 122 are 99.16 pct identical to residues 1 to 120 of 121 from Escherichia coli K-12 : B3103; cytochrome 3235288..3235656 Shigella flexneri 2a str. 2457T 1079593 NP_838620.1 CDS yhaJ NC_004741.1 3235863 3236759 R residues 1 to 298 of 298 are 99.66 pct identical to residues 1 to 298 of 298 from Escherichia coli K-12 : B3105; LYSR-type transcriptional regulator complement(3235863..3236759) Shigella flexneri 2a str. 2457T 1079594 NP_838621.1 CDS yhaK NC_004741.1 3236864 3237565 D residues 1 to 233 of 233 are 99.14 pct identical to residues 1 to 233 of 233 from Escherichia coli K-12 : B3106; hypothetical protein 3236864..3237565 Shigella flexneri 2a str. 2457T 1079629 NP_838622.1 CDS yhaL NC_004741.1 3237588 3237752 D residues 1 to 54 of 54 are 94.44 pct identical to residues 3 to 56 of 56 from Escherichia coli K-12 : B3107; hypothetical protein 3237588..3237752 Shigella flexneri 2a str. 2457T 1079596 NP_838623.1 CDS yhaM NC_004741.1 3237964 3238530 R residues 1 to 188 of 188 are 92.02 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 : B3108; hypothetical protein complement(3237964..3238530) Shigella flexneri 2a str. 2457T 1079597 NP_838624.1 CDS yhaN NC_004741.1 3238466 3239275 R residues 1 to 184 of 269 are 73.36 pct identical to residues 1 to 184 of 187 from Escherichia coli K-12 : B3109; hypothetical protein complement(3238466..3239275) Shigella flexneri 2a str. 2457T 1079598 NP_838625.1 CDS yhaO NC_004741.1 3239303 3240634 R residues 21 to 443 of 443 are 96.69 pct identical to residues 3 to 425 of 425 from Escherichia coli K-12 : B3110; transport system permease complement(3239303..3240634) Shigella flexneri 2a str. 2457T 1079599 NP_838626.1 CDS S3363 NC_004741.1 3240909 3242273 R residues 1 to 453 of 454 are 71.74 pct identical to residues 1 to 453 of 454 from Escherichia coli K-12 : B1814; L-serine deaminase complement(3240909..3242273) Shigella flexneri 2a str. 2457T 1079600 NP_838627.1 CDS yhaR NC_004741.1 3242345 3242734 R residues 1 to 129 of 129 are 100.00 pct identical to residues 22 to 150 of 150 from Escherichia coli K-12 : B3113; hypothetical protein complement(3242345..3242734) Shigella flexneri 2a str. 2457T 1079601 NP_838628.1 CDS tdcE NC_004741.1 3242748 3245042 R residues 1 to 741 of 764 are 97.97 pct identical to residues 1 to 741 of 746 from Escherichia coli K-12 : B3114; formate acetyltransferase 3 complement(3242748..3245042) Shigella flexneri 2a str. 2457T 1079602 NP_838629.2 CDS tdcD NC_004741.1 3245076 3246296 R catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase complement(3245076..3246296) Shigella flexneri 2a str. 2457T 1079603 NP_838630.1 CDS tdcC NC_004741.1 3246310 3247641 R involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC complement(3246310..3247641) Shigella flexneri 2a str. 2457T 1079604 NP_838631.1 CDS tdcB NC_004741.1 3247663 3248652 R catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase complement(3247663..3248652) Shigella flexneri 2a str. 2457T 1079605 NP_838632.1 CDS tdcA NC_004741.1 3248751 3249689 R regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA complement(3248751..3249689) Shigella flexneri 2a str. 2457T 1079606 NP_838633.1 CDS tdcR NC_004741.1 3249879 3250223 D participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3249879..3250223 Shigella flexneri 2a str. 2457T 1079607 NP_838634.1 CDS S3374 NC_004741.1 3252275 3252439 D residues 1 to 54 of 54 are 96.29 pct identical to residues 1 to 54 of 54 from Escherichia coli K-12 : B3122; hypothetical protein 3252275..3252439 Shigella flexneri 2a str. 2457T 1079610 NP_838635.2 CDS yhaD NC_004741.1 3253237 3254382 R residues 1 to 408 of 408 are 94.60 pct identical to residues 1 to 408 of 408 from Escherichia coli K-12 : B3124; glycerate kinase complement(3253237..3254382) Shigella flexneri 2a str. 2457T 1079613 NP_838636.2 CDS garR NC_004741.1 3254479 3255369 R catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase complement(3254479..3255369) Shigella flexneri 2a str. 2457T 1079614 NP_838637.1 CDS yhaU NC_004741.1 3256185 3257519 R residues 1 to 444 of 444 are 95.94 pct identical to residues 1 to 444 of 444 from Escherichia coli K-12 : B3127; transporter complement(3256185..3257519) Shigella flexneri 2a str. 2457T 1079616 NP_838638.1 CDS yhaG NC_004741.1 3257894 3259465 D residues 1 to 523 of 523 are 94.26 pct identical to residues 1 to 523 of 523 from Escherichia coli K-12 : B3128; hydrolase 3257894..3259465 Shigella flexneri 2a str. 2457T 1079617 NP_838639.1 CDS agaR NC_004741.1 3259517 3260341 R transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR complement(3259517..3260341) Shigella flexneri 2a str. 2457T 1079618 NP_838640.1 CDS agaZ NC_004741.1 3260590 3261870 D residues 1 to 426 of 426 are 99.29 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 : B3132; tagatose 6-phosphate kinase 2 3260590..3261870 Shigella flexneri 2a str. 2457T 1079619 NP_838641.1 CDS agaV NC_004741.1 3261857 3262366 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; N-acetylgalactosamine-specific PTS system transporter subunit IIB 3261857..3262366 Shigella flexneri 2a str. 2457T 1079620 NP_838642.1 CDS agaW NC_004741.1 3262377 3263156 D residues 1 to 125 of 259 are 65.60 pct identical to residues 1 to 125 of 133 from Escherichia coli K-12 : B3134; PTS transport; N-acetylgalactosameine-specific IIC component 2 3262377..3263156 Shigella flexneri 2a str. 2457T 1079621 NP_838643.1 CDS agaE NC_004741.1 3263146 3263955 D residues 1 to 269 of 269 are 99.25 pct identical to residues 1 to 269 of 292 from GenPept : >gb|AAG58265.1|AE005542_7 (AE005542) phosphotransferase system enzyme subunit [Escherichia coli O157:H7 EDL933]; PTS transport; transport enzyme subunit 3263146..3263955 Shigella flexneri 2a str. 2457T 1079622 NP_838644.1 CDS agaF NC_004741.1 3264042 3264476 D residues 1 to 144 of 144 are 98.61 pct identical to residues 1 to 144 of 144 from GenPept : >gb|AAG58266.1|AE005542_8 (AE005542) phosphotransferase system enzyme subunit [Escherichia coli O157:H7 EDL933]; PTS transport; transport enzyme subunit 3264042..3264476 Shigella flexneri 2a str. 2457T 1079623 NP_838645.1 CDS agaA NC_004741.1 3264473 3264916 D residues 1 to 139 of 147 are 96.40 pct identical to residues 8 to 146 of 384 from GenPept : >gb|AAF81087.1|AF228498_7 (AF228498) AgaA [Escherichia coli]; N-acetylglucosamine-6-phosphate deacetylase 3264473..3264916 Shigella flexneri 2a str. 2457T 1079624 NP_838646.1 CDS S3388 NC_004741.1 3264945 3265220 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3264945..3265220 Shigella flexneri 2a str. 2457T 1079625 NP_838647.1 CDS S3389 NC_004741.1 3265139 3265642 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 3265139..3265642 Shigella flexneri 2a str. 2457T 1079626 NP_838648.1 CDS agaC NC_004741.1 3265897 3266700 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; N-acetylgalactosamine-specific PTS system transporter subunit IIC 3265897..3266700 Shigella flexneri 2a str. 2457T 1079627 NP_838649.1 CDS agaD NC_004741.1 3266690 3267481 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; N-acetylgalactosamine-specific PTS system transporter subunit IID 3266690..3267481 Shigella flexneri 2a str. 2457T 1079630 NP_838650.1 CDS agaI NC_004741.1 3267482 3268237 D residues 1 to 251 of 251 are 93.62 pct identical to residues 1 to 251 of 251 from Escherichia coli K-12 : B3141; galactosamine-6-phosphate isomerase 3267482..3268237 Shigella flexneri 2a str. 2457T 1079631 NP_838651.1 CDS S3394 NC_004741.1 3268746 3269249 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 ORF2 complement(3268746..3269249) Shigella flexneri 2a str. 2457T 1079632 NP_838652.1 CDS S3395 NC_004741.1 3269168 3269443 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3269168..3269443) Shigella flexneri 2a str. 2457T 1079633 NP_838653.1 CDS yraI NC_004741.1 3270079 3270774 D residues 1 to 231 of 231 are 99.13 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 : B3143; chaperone 3270079..3270774 Shigella flexneri 2a str. 2457T 1079634 NP_838654.1 CDS S3399 NC_004741.1 3272539 3272961 R residues 1 to 140 of 140 are 98.57 pct identical to residues 162 to 301 of 301 from GenPept : >gb|AAD10297.1| (U82084) unknown [bacteriophage SfX]; partial; IS2 orfB complement(3272539..3272961) Shigella flexneri 2a str. 2457T 1079636 NP_838655.2 CDS S3401 NC_004741.1 3273400 3273765 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(3273400..3273765) Shigella flexneri 2a str. 2457T 1078008 NP_838656.1 CDS yraK NC_004741.1 3274664 3275755 D residues 1 to 363 of 363 are 95.31 pct identical to residues 1 to 363 of 363 from Escherichia coli K-12 : B3145; fimbrial protein 3274664..3275755 Shigella flexneri 2a str. 2457T 1079637 NP_838657.1 CDS yraL NC_004741.1 3275798 3276658 R residues 1 to 286 of 286 are 91.95 pct identical to residues 1 to 286 of 286 from Escherichia coli K-12 : B3146; hypothetical protein complement(3275798..3276658) Shigella flexneri 2a str. 2457T 1079639 NP_838658.1 CDS yraM NC_004741.1 3276723 3278759 D residues 1 to 678 of 678 are 88.93 pct identical to residues 1 to 678 of 678 from Escherichia coli K-12 : B3147; glycosylase 3276723..3278759 Shigella flexneri 2a str. 2457T 1079641 NP_838659.1 CDS yraN NC_004741.1 3278717 3279112 D residues 1 to 131 of 131 are 98.47 pct identical to residues 1 to 131 of 131 from Escherichia coli K-12 : B3148; hypothetical protein 3278717..3279112 Shigella flexneri 2a str. 2457T 1079643 NP_838660.1 CDS yraO NC_004741.1 3279132 3279722 D Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3279132..3279722 Shigella flexneri 2a str. 2457T 1077991 NP_838661.1 CDS yraP NC_004741.1 3279732 3280307 D residues 1 to 191 of 191 are 90.57 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B3150; hypothetical protein 3279732..3280307 Shigella flexneri 2a str. 2457T 1079645 NP_838662.1 CDS yraQ NC_004741.1 3280421 3281461 R residues 1 to 346 of 346 are 93.64 pct identical to residues 1 to 346 of 346 from Escherichia coli K-12 : B3151; hypothetical protein complement(3280421..3281461) Shigella flexneri 2a str. 2457T 1079646 NP_838663.1 CDS yraR NC_004741.1 3281534 3282214 R residues 1 to 226 of 226 are 98.67 pct identical to residues 1 to 226 of 226 from Escherichia coli K-12 : B3152; hypothetical protein complement(3281534..3282214) Shigella flexneri 2a str. 2457T 1079647 NP_838664.1 CDS yhbO NC_004741.1 3282255 3282815 D residues 1 to 186 of 186 are 98.92 pct identical to residues 1 to 186 of 186 from Escherichia coli K-12 : B3153; hypothetical protein 3282255..3282815 Shigella flexneri 2a str. 2457T 1079649 NP_838665.1 CDS yhbP NC_004741.1 3282795 3283238 R residues 1 to 147 of 147 are 100.00 pct identical to residues 1 to 147 of 147 from Escherichia coli K-12 : B3154; hypothetical protein complement(3282795..3283238) Shigella flexneri 2a str. 2457T 1079650 NP_838666.1 CDS yhbQ NC_004741.1 3283289 3283591 D residues 1 to 100 of 100 are 99.00 pct identical to residues 1 to 100 of 100 from Escherichia coli K-12 : B3155; GIY-YIG nuclease superfamily protein 3283289..3283591 Shigella flexneri 2a str. 2457T 1078053 NP_838667.1 CDS yhbS NC_004741.1 3283578 3284081 R residues 1 to 167 of 167 are 99.40 pct identical to residues 1 to 167 of 167 from Escherichia coli K-12 : B3156; hypothetical protein complement(3283578..3284081) Shigella flexneri 2a str. 2457T 1079652 NP_838668.1 CDS yhbT NC_004741.1 3284075 3284599 R residues 1 to 174 of 174 are 98.85 pct identical to residues 1 to 174 of 174 from Escherichia coli K-12 : B3157; hypothetical protein complement(3284075..3284599) Shigella flexneri 2a str. 2457T 1079653 NP_838669.1 CDS yhbU NC_004741.1 3284808 3285803 D residues 1 to 331 of 331 are 94.25 pct identical to residues 1 to 331 of 331 from Escherichia coli K-12 : B3158; collagenase 3284808..3285803 Shigella flexneri 2a str. 2457T 1078610 NP_838670.1 CDS yhbV NC_004741.1 3285812 3286690 D residues 1 to 292 of 292 are 98.63 pct identical to residues 7 to 298 of 298 from Escherichia coli K-12 : B3159; hypothetical protein 3285812..3286690 Shigella flexneri 2a str. 2457T 1079654 NP_838671.1 CDS yhbW NC_004741.1 3286771 3287778 D residues 1 to 335 of 335 are 99.40 pct identical to residues 1 to 335 of 335 from Escherichia coli K-12 : B3160; hypothetical protein 3286771..3287778 Shigella flexneri 2a str. 2457T 1079902 NP_838672.1 CDS mtr NC_004741.1 3287896 3289140 R tryptophan transporter of high affinity; tryptophan permease complement(3287896..3289140) Shigella flexneri 2a str. 2457T 1079656 NP_838673.2 CDS deaD NC_004741.1 3289294 3291183 R participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD complement(3289294..3291183) Shigella flexneri 2a str. 2457T 1078673 NP_838674.1 CDS yhbM NC_004741.1 3291363 3292247 R lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI complement(3291363..3292247) Shigella flexneri 2a str. 2457T 1079657 NP_838675.1 CDS pnp NC_004741.1 3292356 3294560 R residues 1 to 713 of 734 are 93.54 pct identical to residues 1 to 713 of 734 from Escherichia coli K-12 : B3164; cytidylate kinase activity; polynucleotide phosphorylase/polyadenylase complement(3292356..3294560) Shigella flexneri 2a str. 2457T 1079659 NP_838676.1 CDS rpsO NC_004741.1 3294738 3295007 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(3294738..3295007) Shigella flexneri 2a str. 2457T 1079660 NP_838677.1 CDS truB NC_004741.1 3295156 3296100 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(3295156..3296100) Shigella flexneri 2a str. 2457T 1079661 NP_838678.1 CDS rbfA NC_004741.1 3296100 3296501 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(3296100..3296501) Shigella flexneri 2a str. 2457T 1079662 NP_838679.1 CDS infB NC_004741.1 3296665 3299313 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(3296665..3299313) Shigella flexneri 2a str. 2457T 1079663 NP_838680.1 CDS nusA NC_004741.1 3299338 3300825 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(3299338..3300825) Shigella flexneri 2a str. 2457T 1078149 NP_838681.2 CDS yhbC NC_004741.1 3300853 3301305 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(3300853..3301305) Shigella flexneri 2a str. 2457T 1079664 NP_838682.1 CDS argG NC_004741.1 3301936 3303279 D catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3301936..3303279 Shigella flexneri 2a str. 2457T 1079667 NP_838683.1 CDS yhbX NC_004741.1 3303287 3303769 R residues 1 to 160 of 160 are 99.37 pct identical to residues 388 to 547 of 547 from Escherichia coli K-12 : B3173; alkaline phosphatase I complement(3303287..3303769) Shigella flexneri 2a str. 2457T 1078079 NP_838684.1 CDS secG NC_004741.1 3305473 3305805 R residues 1 to 110 of 110 are 99.09 pct identical to residues 1 to 110 of 110 from Escherichia coli K-12 : B3175; preprotein translocase subunit SecG complement(3305473..3305805) Shigella flexneri 2a str. 2457T 1077635 NP_838685.1 CDS glmM NC_004741.1 3306033 3307370 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(3306033..3307370) Shigella flexneri 2a str. 2457T 1079670 NP_838686.2 CDS folP NC_004741.1 3307363 3308211 R catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase complement(3307363..3308211) Shigella flexneri 2a str. 2457T 1079671 NP_838687.1 CDS hflB NC_004741.1 3308301 3310235 R inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease complement(3308301..3310235) Shigella flexneri 2a str. 2457T 1079672 NP_838688.1 CDS rrmJ NC_004741.1 3310335 3310964 R Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J complement(3310335..3310964) Shigella flexneri 2a str. 2457T 1079673 NP_838689.1 CDS yhbY NC_004741.1 3311090 3311383 D RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3311090..3311383 Shigella flexneri 2a str. 2457T 1079674 NP_838690.1 CDS greA NC_004741.1 3311539 3312015 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(3311539..3312015) Shigella flexneri 2a str. 2457T 1079675 NP_838691.1 CDS dacB NC_004741.1 3312263 3313696 D penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 3312263..3313696 Shigella flexneri 2a str. 2457T 1079676 NP_838692.1 CDS obgE NC_004741.1 3313882 3315054 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(3313882..3315054) Shigella flexneri 2a str. 2457T 1079677 NP_838693.1 CDS yhbE NC_004741.1 3315070 3316035 R residues 1 to 321 of 321 are 95.01 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B3184; hypothetical protein complement(3315070..3316035) Shigella flexneri 2a str. 2457T 1079678 NP_838694.1 CDS rpmA NC_004741.1 3316162 3316419 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(3316162..3316419) Shigella flexneri 2a str. 2457T 1079396 NP_838695.1 CDS rplU NC_004741.1 3316440 3316751 R residues 1 to 103 of 103 are 100.00 pct identical to residues 1 to 103 of 103 from Escherichia coli K-12 : B3186; 50S ribosomal protein L21 complement(3316440..3316751) Shigella flexneri 2a str. 2457T 1079679 NP_838696.1 CDS ispB NC_004741.1 3317009 3317980 D residues 1 to 323 of 323 are 96.59 pct identical to residues 1 to 323 of 323 from Escherichia coli K-12 : B3187; octaprenyl diphosphate synthase 3317009..3317980 Shigella flexneri 2a str. 2457T 1079548 NP_838697.1 CDS nlp NC_004741.1 3318207 3318485 D activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3318207..3318485 Shigella flexneri 2a str. 2457T 1079682 NP_838698.1 CDS murA NC_004741.1 3318533 3319792 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(3318533..3319792) Shigella flexneri 2a str. 2457T 1079742 NP_838699.1 CDS yrbA NC_004741.1 3319847 3320116 R residues 1 to 89 of 89 are 100.00 pct identical to residues 1 to 89 of 89 from Escherichia coli K-12 : B3190; hypothetical protein complement(3319847..3320116) Shigella flexneri 2a str. 2457T 1079683 NP_838700.1 CDS yrbB NC_004741.1 3320261 3320650 R residues 1 to 129 of 129 are 92.24 pct identical to residues 1 to 129 of 129 from Escherichia coli K-12 : B3191; hypothetical protein complement(3320261..3320650) Shigella flexneri 2a str. 2457T 1079685 NP_838701.1 CDS yrbC NC_004741.1 3320554 3321189 R residues 1 to 211 of 211 are 100.00 pct identical to residues 1 to 211 of 211 from Escherichia coli K-12 : B3192; hypothetical protein complement(3320554..3321189) Shigella flexneri 2a str. 2457T 1079404 NP_838702.1 CDS vpsC NC_004741.1 3321208 3321759 R residues 1 to 183 of 183 are 90.71 pct identical to residues 1 to 183 of 183 from Escherichia coli K-12 : B3193; cytoplasmic membrane protein complement(3321208..3321759) Shigella flexneri 2a str. 2457T 1079686 NP_838703.1 CDS vpsB NC_004741.1 3321764 3322546 R residues 1 to 260 of 260 are 100.00 pct identical to residues 1 to 260 of 260 from Escherichia coli K-12 : B3194; integral membrane protein complement(3321764..3322546) Shigella flexneri 2a str. 2457T 1076490 NP_838704.1 CDS vpsA NC_004741.1 3322554 3323363 R ATP-binding subunit of a ABC toluene efflux transporter; ABC transporter ATP-binding protein complement(3322554..3323363) Shigella flexneri 2a str. 2457T 1079688 NP_838705.1 CDS yrbG NC_004741.1 3323573 3324538 D YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 3323573..3324538 Shigella flexneri 2a str. 2457T 1078234 NP_838706.1 CDS yrbH NC_004741.1 3324552 3325538 D residues 1 to 328 of 328 are 96.34 pct identical to residues 1 to 328 of 328 from Escherichia coli K-12 : B3197; D-arabinose 5-phosphate isomerase 3324552..3325538 Shigella flexneri 2a str. 2457T 1079689 NP_838707.1 CDS yrbI NC_004741.1 3325559 3326125 D forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3325559..3326125 Shigella flexneri 2a str. 2457T 1079690 NP_838708.1 CDS yrbK NC_004741.1 3326122 3326697 D residues 1 to 191 of 191 are 100.00 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B3199; hypothetical protein 3326122..3326697 Shigella flexneri 2a str. 2457T 1079691 NP_838709.1 CDS yhbN NC_004741.1 3326666 3327223 D LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3326666..3327223 Shigella flexneri 2a str. 2457T 1079692 NP_838710.1 CDS yhbG NC_004741.1 3327230 3327955 D residues 1 to 241 of 241 are 96.68 pct identical to residues 1 to 241 of 241 from Escherichia coli K-12 : B3201; ABC transporter ATP-binding protein 3327230..3327955 Shigella flexneri 2a str. 2457T 1079693 NP_838711.1 CDS rpoN NC_004741.1 3328003 3329436 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3328003..3329436 Shigella flexneri 2a str. 2457T 1080356 NP_838712.1 CDS yhbH NC_004741.1 3329459 3329746 D YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 3329459..3329746 Shigella flexneri 2a str. 2457T 1077882 NP_838713.1 CDS ptsN NC_004741.1 3329864 3330355 D residues 1 to 163 of 163 are 100.00 pct identical to residues 1 to 163 of 163 from Escherichia coli K-12 : B3204; regulates N metabolism; PTS IIA-like nitrogen-regulatory protein PtsN 3329864..3330355 Shigella flexneri 2a str. 2457T 1079694 NP_838714.1 CDS yhbJ NC_004741.1 3330401 3331255 D residues 1 to 284 of 284 are 95.77 pct identical to residues 1 to 284 of 284 from Escherichia coli K-12 : B3205; hypothetical protein 3330401..3331255 Shigella flexneri 2a str. 2457T 1079364 NP_838715.1 CDS ptsO NC_004741.1 3331252 3331524 D residues 1 to 90 of 90 are 100.00 pct identical to residues 1 to 90 of 90 from Escherichia coli K-12 : B3206; HPr-like, nitrogen related, exchangesphosphate with Enzymei, Hpr; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3331252..3331524 Shigella flexneri 2a str. 2457T 1079695 NP_838716.1 CDS yrbL NC_004741.1 3331737 3332369 D residues 1 to 210 of 210 are 93.33 pct identical to residues 1 to 210 of 210 from Escherichia coli K-12 : B3207; hypothetical protein 3331737..3332369 Shigella flexneri 2a str. 2457T 1079697 NP_838717.1 CDS yhbL NC_004741.1 3333090 3333743 R residues 1 to 217 of 217 are 94.47 pct identical to residues 4 to 220 of 220 from Escherichia coli K-12 : B3209; isoprenoid biosynthesis protein with amidotransferase-like domain complement(3333090..3333743) Shigella flexneri 2a str. 2457T 1079698 NP_838718.1 CDS arcB NC_004741.1 3333973 3336309 R sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB complement(3333973..3336309) Shigella flexneri 2a str. 2457T 1078081 NP_838719.1 CDS yhcC NC_004741.1 3336405 3337334 R residues 1 to 309 of 309 are 99.67 pct identical to residues 1 to 309 of 309 from Escherichia coli K-12 : B3211; hypothetical protein complement(3336405..3337334) Shigella flexneri 2a str. 2457T 1079699 NP_838720.2 CDS gltB NC_004741.1 3337916 3342469 D catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase 3337916..3342469 Shigella flexneri 2a str. 2457T 1078530 NP_838721.1 CDS gltD NC_004741.1 3342482 3343900 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase 3342482..3343900 Shigella flexneri 2a str. 2457T 1079700 NP_838722.1 CDS S3473 NC_004741.1 3345046 3346116 D residues 1 to 257 of 356 are 86.04 pct identical to residues 36 to 293 of 307 from GenPept : >gb|AAF28144.1|AF153317_45 (AF153317) InsB [Shigella dysenteriae]; IS600 orf 3345046..3346116 Shigella flexneri 2a str. 2457T 1079702 NP_838723.1 CDS yhcH NC_004741.1 3346192 3346656 R residues 1 to 154 of 154 are 90.25 pct identical to residues 1 to 154 of 154 from Escherichia coli K-12 : B3221; hypothetical protein complement(3346192..3346656) Shigella flexneri 2a str. 2457T 1079704 NP_838724.2 CDS yhcI NC_004741.1 3346653 3347528 R catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase complement(3346653..3347528) Shigella flexneri 2a str. 2457T 1079665 NP_838725.1 CDS yhcJ NC_004741.1 3347525 3348214 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(3347525..3348214) Shigella flexneri 2a str. 2457T 1079706 NP_838726.2 CDS nanT NC_004741.1 3348262 3349752 R residues 1 to 506 of 506 are 89.72 pct identical to residues 1 to 506 of 506 from Escherichia coli K-12 : B3224; sialic acid transporter complement(3348262..3349752) Shigella flexneri 2a str. 2457T 1076756 NP_838727.1 CDS nanA NC_004741.1 3349862 3350755 R catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase complement(3349862..3350755) Shigella flexneri 2a str. 2457T 1079707 NP_838728.1 CDS yhcK NC_004741.1 3350877 3351659 R Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR complement(3350877..3351659) Shigella flexneri 2a str. 2457T 1079708 NP_838729.1 CDS S3480 NC_004741.1 3352106 3352381 D residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3352106..3352381 Shigella flexneri 2a str. 2457T 1079709 NP_838730.1 CDS S3481 NC_004741.1 3352300 3352803 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3352300..3352803 Shigella flexneri 2a str. 2457T 1078992 NP_838731.1 CDS yhcL NC_004741.1 3352824 3354191 D YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; cryptic C4-dicarboxylate transporter DcuD 3352824..3354191 Shigella flexneri 2a str. 2457T 1079710 NP_838732.1 CDS sspB NC_004741.1 3354234 3354731 R residues 1 to 133 of 165 are 100.00 pct identical to residues 1 to 133 of 165 from Escherichia coli K-12 : B3228; ClpXP protease specificity-enhancing factor complement(3354234..3354731) Shigella flexneri 2a str. 2457T 1079711 NP_838733.1 CDS sspA NC_004741.1 3354737 3355375 R transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A complement(3354737..3355375) Shigella flexneri 2a str. 2457T 1079712 NP_838734.1 CDS rpsI NC_004741.1 3355770 3356162 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(3355770..3356162) Shigella flexneri 2a str. 2457T 1079713 NP_838735.1 CDS rplM NC_004741.1 3356178 3356606 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(3356178..3356606) Shigella flexneri 2a str. 2457T 1079714 NP_838736.1 CDS yhcM NC_004741.1 3356825 3357952 R residues 1 to 375 of 375 are 98.66 pct identical to residues 1 to 375 of 375 from Escherichia coli K-12 : B3232; hypothetical protein complement(3356825..3357952) Shigella flexneri 2a str. 2457T 1079715 NP_838737.1 CDS yhcB NC_004741.1 3358146 3358544 D residues 1 to 132 of 132 are 78.03 pct identical to residues 3 to 134 of 134 from Escherichia coli K-12 : B3233; cytochrome d ubiquinol oxidase subunit III 3358146..3358544 Shigella flexneri 2a str. 2457T 1079716 NP_838738.1 CDS degS NC_004741.1 3360135 3361202 D residues 1 to 355 of 355 are 89.85 pct identical to residues 1 to 355 of 355 from Escherichia coli K-12 : B3235; serine endoprotease 3360135..3361202 Shigella flexneri 2a str. 2457T 1079718 NP_838739.1 CDS mdh NC_004741.1 3361264 3362202 R oxidizes malate to oxaloacetate; malate dehydrogenase complement(3361264..3362202) Shigella flexneri 2a str. 2457T 1079719 NP_838740.1 CDS argR NC_004741.1 3362637 3363107 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 3362637..3363107 Shigella flexneri 2a str. 2457T 1079720 NP_838741.1 CDS yhcN NC_004741.1 3363421 3363735 D residues 1 to 104 of 104 are 83.65 pct identical to residues 1 to 104 of 104 from Escherichia coli K-12 : B3238; hypothetical protein 3363421..3363735 Shigella flexneri 2a str. 2457T 1079721 NP_838742.1 CDS yhcO NC_004741.1 3363791 3364063 R residues 1 to 90 of 90 are 98.88 pct identical to residues 1 to 90 of 90 from Escherichia coli K-12 : B3239; hypothetical protein complement(3363791..3364063) Shigella flexneri 2a str. 2457T 1079722 NP_838743.1 CDS yhcP NC_004741.1 3364155 3366122 R with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB complement(3364155..3366122) Shigella flexneri 2a str. 2457T 1077875 NP_838744.1 CDS yhcQ NC_004741.1 3366128 3367060 R with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA complement(3366128..3367060) Shigella flexneri 2a str. 2457T 1079723 NP_838745.2 CDS yhcR NC_004741.1 3367068 3367271 R membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein complement(3367068..3367271) Shigella flexneri 2a str. 2457T 1079724 NP_838746.1 CDS yhcS NC_004741.1 3367472 3368383 D residues 1 to 303 of 303 are 99.66 pct identical to residues 7 to 309 of 309 from Escherichia coli K-12 : B3243; DNA-binding transcriptional regulator 3367472..3368383 Shigella flexneri 2a str. 2457T 1079725 NP_838747.1 CDS tldD NC_004741.1 3368511 3369956 R responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD complement(3368511..3369956) Shigella flexneri 2a str. 2457T 1079726 NP_838748.1 CDS yhdP NC_004741.1 3370112 3373072 R residues 1 to 986 of 986 are 99.49 pct identical to residues 1 to 986 of 986 from Escherichia coli K-12 : B3245; hypothetical protein complement(3370112..3373072) Shigella flexneri 2a str. 2457T 1079727 NP_838749.1 CDS cafA NC_004741.1 3373980 3375449 R involved in the processing of the 5'end of 16S rRNA; ribonuclease G complement(3373980..3375449) Shigella flexneri 2a str. 2457T 1079730 NP_838750.1 CDS maf NC_004741.1 3375439 3376032 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(3375439..3376032) Shigella flexneri 2a str. 2457T 1079731 NP_838751.1 CDS mreD NC_004741.1 3376041 3376529 R part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD complement(3376041..3376529) Shigella flexneri 2a str. 2457T 1079732 NP_838752.1 CDS mreC NC_004741.1 3376736 3377632 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(3376736..3377632) Shigella flexneri 2a str. 2457T 1078482 NP_838753.2 CDS mreB NC_004741.1 3377698 3378741 R functions in MreBCD complex in some organisms; rod shape-determining protein MreB complement(3377698..3378741) Shigella flexneri 2a str. 2457T 1079734 NP_838754.1 CDS yhdA NC_004741.1 3379046 3380986 R regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD complement(3379046..3380986) Shigella flexneri 2a str. 2457T 1079735 NP_838755.1 CDS yhdH NC_004741.1 3381138 3382112 D residues 1 to 324 of 324 are 90.74 pct identical to residues 1 to 324 of 324 from Escherichia coli K-12 : B3253; dehydrogenase 3381138..3382112 Shigella flexneri 2a str. 2457T 1079736 NP_838756.1 CDS S3509 NC_004741.1 3382170 3382271 R residues 1 to 33 of 33 are 100.00 pct identical to residues 1 to 33 of 33 from Escherichia coli K-12 : B3254; hypothetical protein complement(3382170..3382271) Shigella flexneri 2a str. 2457T 1079738 NP_838757.1 CDS accB NC_004741.1 3383090 3383560 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3383090..3383560 Shigella flexneri 2a str. 2457T 1080905 NP_838758.1 CDS accC NC_004741.1 3383571 3384920 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3383571..3384920 Shigella flexneri 2a str. 2457T 1080972 NP_838759.1 CDS yhdT NC_004741.1 3385029 3385271 D residues 1 to 80 of 80 are 97.50 pct identical to residues 1 to 80 of 80 from Escherichia coli K-12 : B3257; hypothetical protein 3385029..3385271 Shigella flexneri 2a str. 2457T 1079741 NP_838760.1 CDS panF NC_004741.1 3385261 3386712 D mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3385261..3386712 Shigella flexneri 2a str. 2457T 1078464 NP_838761.1 CDS prmA NC_004741.1 3386724 3387605 D methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 3386724..3387605 Shigella flexneri 2a str. 2457T 1079743 NP_838762.1 CDS yhdG NC_004741.1 3388057 3388899 D residues 1 to 280 of 280 are 99.64 pct identical to residues 42 to 321 of 321 from Escherichia coli K-12 : B3260; dehydrogenase 3388057..3388899 Shigella flexneri 2a str. 2457T 1079744 NP_838763.1 CDS fis NC_004741.1 3388925 3389221 D Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3388925..3389221 Shigella flexneri 2a str. 2457T 1079745 NP_838764.1 CDS yhdJ NC_004741.1 3389307 3390191 D residues 1 to 294 of 294 are 97.95 pct identical to residues 3 to 296 of 296 from Escherichia coli K-12 : B3262; methyltransferase 3389307..3390191 Shigella flexneri 2a str. 2457T 1079687 NP_838765.1 CDS S3519 NC_004741.1 3390469 3390972 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(3390469..3390972) Shigella flexneri 2a str. 2457T 1079747 NP_838766.1 CDS S3520 NC_004741.1 3390891 3391166 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3390891..3391166) Shigella flexneri 2a str. 2457T 1079748 NP_838767.1 CDS yhdW NC_004741.1 3391510 3392427 D residues 1 to 305 of 305 are 99.01 pct identical to residues 1 to 305 of 305 from Escherichia coli K-12 : B3268; periplasmic binding transport protein 3391510..3392427 Shigella flexneri 2a str. 2457T 1079739 NP_838768.1 CDS S3523 NC_004741.1 3393056 3393559 R residues 1 to 97 of 97 are 82.47 pct identical to residues 71 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS1 orfB complement(3393056..3393559) Shigella flexneri 2a str. 2457T 1077904 NP_838769.1 CDS S3524 NC_004741.1 3393478 3393753 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3393478..3393753) Shigella flexneri 2a str. 2457T 1079751 NP_838770.1 CDS yhdY NC_004741.1 3394451 3395554 D residues 1 to 367 of 367 are 98.91 pct identical to residues 2 to 368 of 368 from Escherichia coli K-12 : B3270; transport system permease 3394451..3395554 Shigella flexneri 2a str. 2457T 1079752 NP_838771.1 CDS yhdZ NC_004741.1 3395562 3396320 D residues 1 to 252 of 252 are 98.41 pct identical to residues 1 to 252 of 252 from Escherichia coli K-12 : B3271; ATP-binding component of a transport system 3395562..3396320 Shigella flexneri 2a str. 2457T 1076480 NP_838772.1 CDS yrdA NC_004741.1 3401985 3402755 D residues 1 to 256 of 256 are 100.00 pct identical to residues 1 to 256 of 256 from Escherichia coli K-12 : B3279; transferase 3401985..3402755 Shigella flexneri 2a str. 2457T 1079758 NP_838773.1 CDS yrdB NC_004741.1 3402731 3402988 R residues 1 to 85 of 85 are 100.00 pct identical to residues 1 to 85 of 85 from Escherichia coli K-12 : B3280; hypothetical protein complement(3402731..3402988) Shigella flexneri 2a str. 2457T 1079760 NP_838774.1 CDS aroE NC_004741.1 3402985 3403803 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(3402985..3403803) Shigella flexneri 2a str. 2457T 1079761 NP_838775.1 CDS yrdC NC_004741.1 3403808 3404380 R RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor complement(3403808..3404380) Shigella flexneri 2a str. 2457T 1079762 NP_838776.1 CDS yrdD NC_004741.1 3404385 3404903 R residues 1 to 162 of 162 are 95.06 pct identical to residues 8 to 169 of 169 from Escherichia coli K-12 : B3283; DNA topoisomerase complement(3404385..3404903) Shigella flexneri 2a str. 2457T 1079764 NP_838777.1 CDS smg NC_004741.1 3404956 3405414 R residues 1 to 152 of 152 are 100.00 pct identical to residues 6 to 157 of 157 from Escherichia coli K-12 : B3284; hypothetical protein complement(3404956..3405414) Shigella flexneri 2a str. 2457T 1079765 NP_838778.1 CDS smf NC_004741.1 3405401 3406525 R residues 1 to 374 of 374 are 97.59 pct identical to residues 1 to 374 of 374 from NRprotein_Feb2003 : >ref|NP_289847.1| smf gene product [Escherichia coli O157:H7 EDL933] pir||C85993 hypothetical protein smf [imported] - Escherichia coli (strain O157:H7, substrain EDL933) gb|AAG58407.1|AE005555_7 smf gene product [Escherichia coli O157:H7 EDL933]; DNA protecting protein DprA complement(3405401..3406525) Shigella flexneri 2a str. 2457T 1079766 NP_838779.1 CDS def NC_004741.1 3406690 3407199 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3406690..3407199 Shigella flexneri 2a str. 2457T 1079767 NP_838780.1 CDS fmt NC_004741.1 3407214 3408161 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3407214..3408161 Shigella flexneri 2a str. 2457T 1079768 NP_838781.1 CDS sun NC_004741.1 3408207 3409496 D catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase B 3408207..3409496 Shigella flexneri 2a str. 2457T 1078522 NP_838782.1 CDS trkA NC_004741.1 3409518 3410894 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3409518..3410894 Shigella flexneri 2a str. 2457T 1079769 NP_838783.1 CDS S3547 NC_004741.1 3411075 3411749 D residues 1 to 224 of 224 are 99.55 pct identical to residues 1 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 3411075..3411749 Shigella flexneri 2a str. 2457T 1079770 NP_838784.1 CDS S3548 NC_004741.1 3411746 3412096 D residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAK18528.1|AF348706_217 (AF348706) IS orf [Shigella flexneri]; ISSfl3 orfB 3411746..3412096 Shigella flexneri 2a str. 2457T 1079771 NP_838785.1 CDS S3549 NC_004741.1 3412093 3413694 D residues 1 to 533 of 533 are 96.99 pct identical to residues 1 to 533 of 533 from GenPept : >gb|AAL72376.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfC 3412093..3413694 Shigella flexneri 2a str. 2457T 1079772 NP_838786.1 CDS lysC NC_004741.1 3413860 3415209 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III complement(3413860..3415209) Shigella flexneri 2a str. 2457T 1079773 NP_838787.1 CDS pgi NC_004741.1 3415734 3417383 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 3415734..3417383 Shigella flexneri 2a str. 2457T 1079774 NP_838788.1 CDS yjbE NC_004741.1 3417846 3418088 D residues 1 to 80 of 80 are 98.75 pct identical to residues 1 to 80 of 80 from Escherichia coli K-12 : B4026; hypothetical protein 3417846..3418088 Shigella flexneri 2a str. 2457T 1076477 NP_838789.1 CDS yjbF NC_004741.1 3418172 3418840 D residues 1 to 222 of 222 are 93.69 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 : B4027; hypothetical protein 3418172..3418840 Shigella flexneri 2a str. 2457T 1079776 NP_838790.1 CDS yjbG NC_004741.1 3418837 3419574 D residues 1 to 245 of 245 are 90.20 pct identical to residues 1 to 245 of 245 from Escherichia coli K-12 : B4028; hypothetical protein 3418837..3419574 Shigella flexneri 2a str. 2457T 1079410 NP_838791.1 CDS yjbH NC_004741.1 3419574 3421670 D residues 1 to 698 of 698 are 99.57 pct identical to residues 1 to 698 of 698 from Escherichia coli K-12 : B4029; hypothetical protein 3419574..3421670 Shigella flexneri 2a str. 2457T 1079777 NP_838792.1 CDS yjbA NC_004741.1 3422265 3422675 D residues 1 to 136 of 136 are 84.55 pct identical to residues 1 to 136 of 136 from Escherichia coli K-12 : B4030; phosphate-starvation-inducible protein PsiE 3422265..3422675 Shigella flexneri 2a str. 2457T 1080961 NP_838793.1 CDS xylE NC_004741.1 3422719 3424194 R xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE complement(3422719..3424194) Shigella flexneri 2a str. 2457T 1080770 NP_838794.1 CDS malG NC_004741.1 3424565 3425455 R with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease complement(3424565..3425455) Shigella flexneri 2a str. 2457T 1079778 NP_838795.1 CDS malF NC_004741.1 3425470 3427014 R with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein complement(3425470..3427014) Shigella flexneri 2a str. 2457T 1079779 NP_838796.1 CDS malE NC_004741.1 3427168 3428358 R functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein complement(3427168..3428358) Shigella flexneri 2a str. 2457T 1079799 NP_838797.1 CDS malK NC_004741.1 3428723 3429838 D with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 3428723..3429838 Shigella flexneri 2a str. 2457T 1079780 NP_838798.1 CDS lamB NC_004741.1 3429913 3431250 D porin involved in the transport of maltose and maltodextrins; maltoporin 3429913..3431250 Shigella flexneri 2a str. 2457T 1079781 NP_838799.1 CDS malM NC_004741.1 3431402 3432322 D residues 1 to 306 of 306 are 80.71 pct identical to residues 1 to 306 of 306 from Escherichia coli K-12 : B4037; maltose regulon periplasmic protein 3431402..3432322 Shigella flexneri 2a str. 2457T 1079782 NP_838800.1 CDS ubiC NC_004741.1 3434354 3434851 D catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 3434354..3434851 Shigella flexneri 2a str. 2457T 1079290 NP_838801.1 CDS ubiA NC_004741.1 3434864 3435736 D catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 3434864..3435736 Shigella flexneri 2a str. 2457T 1079784 NP_838802.2 CDS plsB NC_004741.1 3435891 3438314 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(3435891..3438314) Shigella flexneri 2a str. 2457T 1079786 NP_838803.1 CDS dgkA NC_004741.1 3438485 3438853 D residues 1 to 122 of 122 are 90.16 pct identical to residues 1 to 122 of 122 from Escherichia coli K-12 : B4042; diacylglycerol kinase 3438485..3438853 Shigella flexneri 2a str. 2457T 1079787 NP_838804.1 CDS lexA NC_004741.1 3438963 3439571 D Represses a number of genes involved in the response to DNA damage; LexA repressor 3438963..3439571 Shigella flexneri 2a str. 2457T 1079789 NP_838805.2 CDS dinF NC_004741.1 3439644 3440969 D residues 1 to 459 of 459 are 83.22 pct identical to residues 1 to 459 of 459 from Escherichia coli K-12 : B4044; DNA-damage-inducible SOS response protein 3439644..3440969 Shigella flexneri 2a str. 2457T 1079791 NP_838806.1 CDS yjbJ NC_004741.1 3441085 3441294 D unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 3441085..3441294 Shigella flexneri 2a str. 2457T 1079792 NP_838807.2 CDS yjbK NC_004741.1 3441336 3441851 R Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor complement(3441336..3441851) Shigella flexneri 2a str. 2457T 1079794 NP_838808.1 CDS yjbM NC_004741.1 3442447 3443154 D residues 1 to 235 of 235 are 90.63 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B4048; hypothetical protein 3442447..3443154 Shigella flexneri 2a str. 2457T 1079795 NP_838809.1 CDS yjbN NC_004741.1 3443535 3444554 D residues 1 to 339 of 339 are 95.87 pct identical to residues 7 to 345 of 345 from Escherichia coli K-12 : B4049; tRNA-dihydrouridine synthase A 3443535..3444554 Shigella flexneri 2a str. 2457T 1079796 NP_838810.2 CDS pspG NC_004741.1 3444688 3444930 D coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 3444688..3444930 Shigella flexneri 2a str. 2457T 1077388 NP_838811.1 CDS qor NC_004741.1 3445096 3446079 R residues 1 to 327 of 327 are 94.49 pct identical to residues 1 to 327 of 327 from Escherichia coli K-12 : B4051; quinone oxidoreductase, NADPH-dependent complement(3445096..3446079) Shigella flexneri 2a str. 2457T 1079797 NP_838812.1 CDS dnaB NC_004741.1 3446162 3447577 D unwinds double stranded DNA; replicative DNA helicase 3446162..3447577 Shigella flexneri 2a str. 2457T 1079798 NP_838813.1 CDS alr NC_004741.1 3447630 3448709 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 3447630..3448709 Shigella flexneri 2a str. 2457T 1079800 NP_838814.1 CDS tyrB NC_004741.1 3448962 3450155 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 3448962..3450155 Shigella flexneri 2a str. 2457T 1079801 NP_838815.1 CDS aphA NC_004741.1 3451264 3451977 D Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 3451264..3451977 Shigella flexneri 2a str. 2457T 1079802 NP_838816.1 CDS yjbQ NC_004741.1 3452088 3452504 D residues 1 to 138 of 138 are 99.27 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 : B4056; hypothetical protein 3452088..3452504 Shigella flexneri 2a str. 2457T 1079804 NP_838817.1 CDS yjbR NC_004741.1 3452508 3452864 D residues 1 to 118 of 118 are 99.15 pct identical to residues 1 to 118 of 118 from Escherichia coli K-12 : B4057; hypothetical protein 3452508..3452864 Shigella flexneri 2a str. 2457T 1080937 NP_838818.1 CDS uvrA NC_004741.1 3452899 3455721 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(3452899..3455721) Shigella flexneri 2a str. 2457T 1079805 NP_838819.1 CDS ssb NC_004741.1 3455975 3456511 D binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 3455975..3456511 Shigella flexneri 2a str. 2457T 1079806 NP_838820.1 CDS S3585 NC_004741.1 3456619 3457122 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(3456619..3457122) Shigella flexneri 2a str. 2457T 1078153 NP_838821.1 CDS S3586 NC_004741.1 3457041 3457316 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3457041..3457316) Shigella flexneri 2a str. 2457T 1079807 NP_838822.1 CDS yjcB NC_004741.1 3457386 3457736 R residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from Escherichia coli K-12 : B4060; hypothetical protein complement(3457386..3457736) Shigella flexneri 2a str. 2457T 1079808 NP_838823.1 CDS soxS NC_004741.1 3459676 3459999 R regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS complement(3459676..3459999) Shigella flexneri 2a str. 2457T 1076458 NP_838824.1 CDS soxR NC_004741.1 3460085 3460549 D residues 1 to 154 of 154 are 100.00 pct identical to residues 1 to 154 of 154 from Escherichia coli K-12 : B4063; redox-sensing activator of soxS 3460085..3460549 Shigella flexneri 2a str. 2457T 1079812 NP_838825.1 CDS yjcD NC_004741.1 3461255 3462604 D residues 1 to 449 of 449 are 86.63 pct identical to residues 1 to 449 of 449 from Escherichia coli K-12 : B4064; hypothetical protein 3461255..3462604 Shigella flexneri 2a str. 2457T 1079813 NP_838826.1 CDS yjcE NC_004741.1 3462755 3464404 D residues 1 to 527 of 549 are 85.95 pct identical to residues 1 to 527 of 549 from Escherichia coli K-12 : B4065; hypothetical protein 3462755..3464404 Shigella flexneri 2a str. 2457T 1079814 NP_838827.1 CDS yjcF NC_004741.1 3464558 3465850 R residues 1 to 430 of 430 are 85.81 pct identical to residues 1 to 430 of 430 from Escherichia coli K-12 : B4066; hypothetical protein complement(3464558..3465850) Shigella flexneri 2a str. 2457T 1079815 NP_838828.1 CDS actP NC_004741.1 3466028 3467677 R member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease complement(3466028..3467677) Shigella flexneri 2a str. 2457T 1078958 NP_838829.1 CDS yjcH NC_004741.1 3467674 3467988 R residues 1 to 104 of 104 are 89.42 pct identical to residues 1 to 104 of 104 from Escherichia coli K-12 : B4068; hypothetical protein complement(3467674..3467988) Shigella flexneri 2a str. 2457T 1080963 NP_838830.1 CDS nrfA NC_004741.1 3470539 3471975 D catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 3470539..3471975 Shigella flexneri 2a str. 2457T 1079817 NP_838831.1 CDS nrfB NC_004741.1 3472020 3472586 D part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 3472020..3472586 Shigella flexneri 2a str. 2457T 1079818 NP_838832.1 CDS nrfC NC_004741.1 3472583 3473254 D residues 1 to 223 of 223 are 100.00 pct identical to residues 1 to 223 of 223 from Escherichia coli K-12 : B4072; Fe-S centers; formate-dependent nitrite reductase 3472583..3473254 Shigella flexneri 2a str. 2457T 1079819 NP_838833.1 CDS nrfD NC_004741.1 3473251 3474207 D residues 1 to 318 of 318 are 86.16 pct identical to residues 1 to 318 of 318 from Escherichia coli K-12 : B4073; formate-dependent nitrate reductase, transmembrane protein 3473251..3474207 Shigella flexneri 2a str. 2457T 1078385 NP_838834.1 CDS nrfE NC_004741.1 3474287 3475945 D with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 3474287..3475945 Shigella flexneri 2a str. 2457T 1079820 NP_838835.1 CDS nrfF NC_004741.1 3475938 3476321 D residues 1 to 102 of 127 are 86.27 pct identical to residues 1 to 102 of 127 from Escherichia coli K-12 : B4075; formate-dependent nitrite reductase complex subunit NrfF 3475938..3476321 Shigella flexneri 2a str. 2457T 1079822 NP_838836.1 CDS nrfG NC_004741.1 3476318 3476914 D residues 1 to 198 of 198 are 98.48 pct identical to residues 1 to 198 of 198 from Escherichia coli K-12 : B4076; formate-dependent nitrite reductase complex subunit NrfG 3476318..3476914 Shigella flexneri 2a str. 2457T 1079823 NP_838837.1 CDS gltP NC_004741.1 3477256 3478569 D carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 3477256..3478569 Shigella flexneri 2a str. 2457T 1079824 NP_838838.1 CDS yjcO NC_004741.1 3478647 3479315 R residues 1 to 222 of 222 are 100.00 pct identical to residues 8 to 229 of 229 from Escherichia coli K-12 : B4078; hypothetical protein complement(3478647..3479315) Shigella flexneri 2a str. 2457T 1079825 NP_838839.1 CDS yjcP NC_004741.1 3481775 3483241 R part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; outer membrane efflux protein MdtP complement(3481775..3483241) Shigella flexneri 2a str. 2457T 1079826 NP_838840.2 CDS yjcQ NC_004741.1 3483238 3485280 R possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO complement(3483238..3485280) Shigella flexneri 2a str. 2457T 1079827 NP_838841.1 CDS yjcR NC_004741.1 3485280 3486311 R with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN complement(3485280..3486311) Shigella flexneri 2a str. 2457T 1079828 NP_838842.1 CDS S3609 NC_004741.1 3486478 3486753 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3486478..3486753 Shigella flexneri 2a str. 2457T 1079829 NP_838843.1 CDS S3610 NC_004741.1 3486672 3487175 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 3486672..3487175 Shigella flexneri 2a str. 2457T 1079830 NP_838844.1 CDS phnE NC_004741.1 3487169 3487393 R residues 1 to 68 of 74 are 98.52 pct identical to residues 1 to 68 of 206 from Escherichia coli K-12 : B4104; membrane channel protein component of phosphonate transporter complement(3487169..3487393) Shigella flexneri 2a str. 2457T 1079831 NP_838845.1 CDS phnD NC_004741.1 3487448 3488464 R residues 1 to 338 of 338 are 98.52 pct identical to residues 1 to 338 of 338 from Escherichia coli K-12 : B4105; periplasmic binding protein component of phosphonate transporter complement(3487448..3488464) Shigella flexneri 2a str. 2457T 1079832 NP_838846.1 CDS phnC NC_004741.1 3488489 3489277 R residues 1 to 262 of 262 are 98.09 pct identical to residues 1 to 262 of 262 from Escherichia coli K-12 : B4106; phosphonate/organophosphate ester transporter subunit complement(3488489..3489277) Shigella flexneri 2a str. 2457T 1079833 NP_838847.1 CDS phnB NC_004741.1 3489410 3489853 R residues 1 to 147 of 147 are 99.31 pct identical to residues 1 to 147 of 147 from Escherichia coli K-12 : B4107; hypothetical protein complement(3489410..3489853) Shigella flexneri 2a str. 2457T 1079834 NP_838848.1 CDS phnA NC_004741.1 3490011 3490346 R residues 1 to 111 of 111 are 100.00 pct identical to residues 1 to 111 of 111 from Escherichia coli K-12 : B4108; hypothetical protein complement(3490011..3490346) Shigella flexneri 2a str. 2457T 1079835 NP_838849.1 CDS yjdA NC_004741.1 3490749 3492977 D residues 1 to 742 of 742 are 95.28 pct identical to residues 1 to 742 of 742 from Escherichia coli K-12 : B4109; hypothetical protein 3490749..3492977 Shigella flexneri 2a str. 2457T 1079836 NP_838850.1 CDS yjcZ NC_004741.1 3493007 3493852 D residues 1 to 281 of 281 are 97.15 pct identical to residues 1 to 281 of 281 from Escherichia coli K-12 : B4110; hypothetical protein 3493007..3493852 Shigella flexneri 2a str. 2457T 1079837 NP_838851.1 CDS proP NC_004741.1 3494116 3495618 D residues 1 to 500 of 500 are 97.00 pct identical to residues 1 to 500 of 500 from Escherichia coli K-12 : B4111; proline/glycine betaine transporter 3494116..3495618 Shigella flexneri 2a str. 2457T 1079838 NP_838852.1 CDS basS NC_004741.1 3495795 3496895 R residues 4 to 366 of 366 are 99.17 pct identical to residues 1 to 363 of 363 from Escherichia coli K-12 : B4112; sensor protein BasS/PmrB complement(3495795..3496895) Shigella flexneri 2a str. 2457T 1079839 NP_838853.1 CDS basR NC_004741.1 3496896 3497564 R response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR complement(3496896..3497564) Shigella flexneri 2a str. 2457T 1079840 NP_838854.1 CDS yjdB NC_004741.1 3497561 3499234 R with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein complement(3497561..3499234) Shigella flexneri 2a str. 2457T 1079841 NP_838855.1 CDS yjdE NC_004741.1 3499308 3500645 R residues 1 to 445 of 445 are 92.35 pct identical to residues 1 to 445 of 445 from Escherichia coli K-12 : B4115; arginine:agmatin antiporter complement(3499308..3500645) Shigella flexneri 2a str. 2457T 1079842 NP_838856.1 CDS adiY NC_004741.1 3500782 3501543 R residues 1 to 253 of 253 are 93.28 pct identical to residues 1 to 253 of 253 from Escherichia coli K-12 : B4116; ARAC-type regulatory protein complement(3500782..3501543) Shigella flexneri 2a str. 2457T 1079843 NP_838857.1 CDS adiA NC_004741.1 3501868 3504135 R residues 1 to 755 of 755 are 99.47 pct identical to residues 2 to 756 of 756 from Escherichia coli K-12 : B4117; biodegradative arginine decarboxylase complement(3501868..3504135) Shigella flexneri 2a str. 2457T 1079844 NP_838858.1 CDS melR NC_004741.1 3504334 3505242 R residues 1 to 302 of 302 are 99.66 pct identical to residues 1 to 302 of 302 from Escherichia coli K-12 : B4118; DNA-binding transcriptional regulator MelR complement(3504334..3505242) Shigella flexneri 2a str. 2457T 1079845 NP_838859.1 CDS melA NC_004741.1 3505525 3506880 D residues 1 to 451 of 451 are 98.89 pct identical to residues 1 to 451 of 451 from Escherichia coli K-12 : B4119; alpha-galactosidase 3505525..3506880 Shigella flexneri 2a str. 2457T 1079846 NP_838860.1 CDS melB NC_004741.1 3506995 3508404 D residues 1 to 469 of 469 are 96.37 pct identical to residues 1 to 469 of 469 from Escherichia coli K-12 : B4120; melibiose:sodium symporter 3506995..3508404 Shigella flexneri 2a str. 2457T 1079847 NP_838861.1 CDS yjdF NC_004741.1 3508543 3509172 R residues 1 to 209 of 209 are 83.25 pct identical to residues 1 to 209 of 209 from Escherichia coli K-12 : B4121; hypothetical protein complement(3508543..3509172) Shigella flexneri 2a str. 2457T 1079848 NP_838862.1 CDS fumB NC_004741.1 3509295 3510941 R residues 1 to 548 of 548 are 96.35 pct identical to residues 1 to 548 of 548 from Escherichia coli K-12 : B4122; anaerobic isozyme; fumarase B, fumarate hydratase class I complement(3509295..3510941) Shigella flexneri 2a str. 2457T 1079849 NP_838863.1 CDS dcuB NC_004741.1 3511019 3512359 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter complement(3511019..3512359) Shigella flexneri 2a str. 2457T 1079850 NP_838864.1 CDS yjdG NC_004741.1 3512930 3513649 R response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR complement(3512930..3513649) Shigella flexneri 2a str. 2457T 1079851 NP_838865.1 CDS yjdH NC_004741.1 3513646 3515277 R C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS complement(3513646..3515277) Shigella flexneri 2a str. 2457T 1079852 NP_838866.2 CDS S3633 NC_004741.1 3515692 3516057 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3515692..3516057 Shigella flexneri 2a str. 2457T 1079853 NP_838867.2 CDS S3634 NC_004741.1 3516015 3516920 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3516015..3516920 Shigella flexneri 2a str. 2457T 1079854 NP_838868.1 CDS yjbC NC_004741.1 3517246 3518118 R catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F complement(3517246..3518118) Shigella flexneri 2a str. 2457T 1079855 NP_838869.1 CDS sorC NC_004741.1 3518466 3519413 D residues 1 to 315 of 315 are 98.73 pct identical to residues 8 to 322 of 322 from GenPept : >gb|AAG59220.1|AE005634_10 (AE005634) transcriptional regulator of sorbose uptake and utilization genes [Escherichia coli O157:H7 EDL933]; sor-operon regulator 3518466..3519413 Shigella flexneri 2a str. 2457T 1079856 NP_838870.1 CDS sorD NC_004741.1 3519483 3520289 D Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase 3519483..3520289 Shigella flexneri 2a str. 2457T 1079857 NP_838871.1 CDS sorF NC_004741.1 3520299 3520706 D residues 1 to 135 of 135 are 97.03 pct identical to residues 1 to 135 of 135 from GenPept : >gb|AAG59218.1|AE005634_8 (AE005634) sorbose PTS component [Escherichia coli O157:H7 EDL933]; sorbose-permease PTS system IIA component 3520299..3520706 Shigella flexneri 2a str. 2457T 1079858 NP_838872.1 CDS sorB NC_004741.1 3520706 3521200 D residues 1 to 164 of 164 are 99.39 pct identical to residues 1 to 164 of 164 from GenPept : >gb|AAG59217.1|AE005634_7 (AE005634) sorbose PTS component [Escherichia coli O157:H7 EDL933]; sorbose-permease PTS system IIB component 3520706..3521200 Shigella flexneri 2a str. 2457T 1079859 NP_838873.1 CDS sorA NC_004741.1 3521323 3522063 D residues 1 to 246 of 246 are 86.99 pct identical to residues 20 to 265 of 265 from GenPept : >gb|AAG59216.1|AE005634_6 (AE005634) sorbose PTS component [Escherichia coli O157:H7 EDL933]; sorbose-permease PTS system IIC component 3521323..3522063 Shigella flexneri 2a str. 2457T 1079860 NP_838874.1 CDS sorM NC_004741.1 3522074 3522862 D residues 1 to 262 of 262 are 82.48 pct identical to residues 1 to 274 of 274 from GenPept : >gb|AAG59215.1|AE005634_5 (AE005634) sorbose PTS component [Escherichia coli O157:H7 EDL933]; sorbose-permease PTS system IID component 3522074..3522862 Shigella flexneri 2a str. 2457T 1079861 NP_838875.1 CDS sorE NC_004741.1 3522914 3524143 D residues 1 to 409 of 409 are 95.11 pct identical to residues 5 to 413 of 413 from GenPept : >gb|AAG59214.1|AE005634_4 (AE005634) L-sorbose-1-P-reductase [Escherichia coli O157:H7 EDL933]; L-sorbose-1-P-reductase 3522914..3524143 Shigella flexneri 2a str. 2457T 1079862 NP_838876.1 CDS pepE NC_004741.1 3524525 3525214 D alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 3524525..3525214 Shigella flexneri 2a str. 2457T 1079863 NP_838877.1 CDS yjbB NC_004741.1 3525305 3526936 R residues 16 to 543 of 543 are 87.50 pct identical to residues 16 to 543 of 543 from Escherichia coli K-12 : B4020; alpha helix protein complement(3525305..3526936) Shigella flexneri 2a str. 2457T 1079864 NP_838878.1 CDS metH NC_004741.1 3527156 3530839 R one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase complement(3527156..3530839) Shigella flexneri 2a str. 2457T 1079865 NP_838879.2 CDS iclR NC_004741.1 3531039 3531863 D regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; IclR family transcriptional regulator 3531039..3531863 Shigella flexneri 2a str. 2457T 1079866 NP_838880.1 CDS aceA NC_004741.1 3536254 3537558 R Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; isocitrate lyase complement(3536254..3537558) Shigella flexneri 2a str. 2457T 1079869 NP_838881.1 CDS metA NC_004741.1 3539458 3540387 R catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase complement(3539458..3540387) Shigella flexneri 2a str. 2457T 1079871 NP_838882.1 CDS yjaB NC_004741.1 3540544 3540987 D residues 1 to 146 of 147 are 96.57 pct identical to residues 1 to 146 of 147 from Escherichia coli K-12 : B4012; hypothetical protein 3540544..3540987 Shigella flexneri 2a str. 2457T 1079872 NP_838883.1 CDS purH NC_004741.1 3546727 3548316 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 3546727..3548316 Shigella flexneri 2a str. 2457T 1079877 NP_838884.1 CDS purD NC_004741.1 3548328 3549617 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 3548328..3549617 Shigella flexneri 2a str. 2457T 1079878 NP_838885.1 CDS hydG NC_004741.1 3549614 3550939 R DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR complement(3549614..3550939) Shigella flexneri 2a str. 2457T 1079879 NP_838886.1 CDS hydH NC_004741.1 3550936 3552312 R residues 1 to 458 of 458 are 74.40 pct identical to residues 1 to 465 of 465 from Escherichia coli K-12 : B4003; sensor protein ZraS complement(3550936..3552312) Shigella flexneri 2a str. 2457T 1079880 NP_838887.2 CDS zraP NC_004741.1 3552550 3552975 D residues 1 to 166 of 188 are 91.56 pct identical to residues 1 to 166 of 188 from Escherichia coli K-12 : B4002; zinc resistance protein 3552550..3552975 Shigella flexneri 2a str. 2457T 1079881 NP_838888.1 CDS yjaH NC_004741.1 3552977 3553672 R residues 1 to 231 of 231 are 94.37 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 : B4001; hypothetical protein complement(3552977..3553672) Shigella flexneri 2a str. 2457T 1079882 NP_838889.1 CDS hupA NC_004741.1 3553685 3553957 R histone-like DNA-binding protein; transcriptional regulator HU subunit alpha complement(3553685..3553957) Shigella flexneri 2a str. 2457T 1079883 NP_838890.1 CDS yjaG NC_004741.1 3554144 3554734 R residues 1 to 196 of 196 are 98.97 pct identical to residues 1 to 196 of 196 from Escherichia coli K-12 : B3999; hypothetical protein complement(3554144..3554734) Shigella flexneri 2a str. 2457T 1079884 NP_838891.1 CDS nfi NC_004741.1 3554777 3555448 R Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V complement(3554777..3555448) Shigella flexneri 2a str. 2457T 1079885 NP_838892.1 CDS hemE NC_004741.1 3555605 3556669 R catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase complement(3555605..3556669) Shigella flexneri 2a str. 2457T 1079886 NP_838893.1 CDS nudC NC_004741.1 3556709 3557482 R can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase complement(3556709..3557482) Shigella flexneri 2a str. 2457T 1079887 NP_838894.1 CDS yjaE NC_004741.1 3557577 3558053 D binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 3557577..3558053 Shigella flexneri 2a str. 2457T 1079888 NP_838895.1 CDS thiC NC_004741.1 3558287 3560182 D required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 3558287..3560182 Shigella flexneri 2a str. 2457T 1079889 NP_838896.1 CDS thiE NC_004741.1 3560182 3560817 D catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 3560182..3560817 Shigella flexneri 2a str. 2457T 1079890 NP_838897.1 CDS thiF NC_004741.1 3560810 3561565 D catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate; thiamine biosynthesis protein ThiF 3560810..3561565 Shigella flexneri 2a str. 2457T 1079891 NP_838898.2 CDS thiG NC_004741.1 3561751 3562521 D functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 3561751..3562521 Shigella flexneri 2a str. 2457T 1079892 NP_838899.1 CDS thiH NC_004741.1 3562518 3563651 D in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 3562518..3563651 Shigella flexneri 2a str. 2457T 1079893 NP_838900.1 CDS rpoC NC_004741.1 3563893 3568116 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(3563893..3568116) Shigella flexneri 2a str. 2457T 1079894 NP_838901.1 CDS rpoB NC_004741.1 3568193 3572221 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(3568193..3572221) Shigella flexneri 2a str. 2457T 1079895 NP_838902.1 CDS rplL NC_004741.1 3572541 3572906 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(3572541..3572906) Shigella flexneri 2a str. 2457T 1079896 NP_838903.1 CDS rplJ NC_004741.1 3572973 3573470 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(3572973..3573470) Shigella flexneri 2a str. 2457T 1079897 NP_838904.1 CDS rplA NC_004741.1 3573883 3574587 R in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 complement(3573883..3574587) Shigella flexneri 2a str. 2457T 1079898 NP_838905.1 CDS rplK NC_004741.1 3574591 3575019 R binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 complement(3574591..3575019) Shigella flexneri 2a str. 2457T 1079899 NP_838906.1 CDS nusG NC_004741.1 3575178 3575723 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(3575178..3575723) Shigella flexneri 2a str. 2457T 1079733 NP_838907.1 CDS secE NC_004741.1 3575725 3576108 R forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(3575725..3576108) Shigella flexneri 2a str. 2457T 1080964 NP_838908.1 CDS tuf NC_004741.1 3576338 3577522 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(3576338..3577522) Shigella flexneri 2a str. 2457T 1079900 NP_838909.1 CDS S3687 NC_004741.1 3578098 3578253 D residues 1 to 51 of 51 are 98.03 pct identical to residues 1 to 51 of 51 from Escherichia coli K-12 : B3975; hypothetical protein 3578098..3578253 Shigella flexneri 2a str. 2457T 1079022 NP_838910.1 CDS coaA NC_004741.1 3578464 3579390 D catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 3578464..3579390 Shigella flexneri 2a str. 2457T 1079904 NP_838911.1 CDS birA NC_004741.1 3579419 3580384 R catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase complement(3579419..3580384) Shigella flexneri 2a str. 2457T 1079905 NP_838912.1 CDS murB NC_004741.1 3580381 3581409 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(3580381..3581409) Shigella flexneri 2a str. 2457T 1079906 NP_838913.2 CDS murI NC_004741.1 3586922 3587779 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(3586922..3587779) Shigella flexneri 2a str. 2457T 1079914 NP_838914.1 CDS btuB NC_004741.1 3587724 3589568 R involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter complement(3587724..3589568) Shigella flexneri 2a str. 2457T 1080549 NP_838915.1 CDS trmA NC_004741.1 3589937 3591037 D catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 3589937..3591037 Shigella flexneri 2a str. 2457T 1080805 NP_838916.1 CDS yijD NC_004741.1 3591077 3591436 R residues 1 to 119 of 119 are 99.15 pct identical to residues 1 to 119 of 119 from Escherichia coli K-12 : B3964; hypothetical protein complement(3591077..3591436) Shigella flexneri 2a str. 2457T 1079915 NP_838917.1 CDS yijC NC_004741.1 3591436 3592140 R negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR complement(3591436..3592140) Shigella flexneri 2a str. 2457T 1079913 NP_838918.2 CDS udhA NC_004741.1 3592407 3593807 D catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 3592407..3593807 Shigella flexneri 2a str. 2457T 1079916 NP_838919.1 CDS oxyR NC_004741.1 3593790 3594707 R Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR complement(3593790..3594707) Shigella flexneri 2a str. 2457T 1079917 NP_838920.1 CDS S3704 NC_004741.1 3595902 3596405 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS1 orfB complement(3595902..3596405) Shigella flexneri 2a str. 2457T 1076452 NP_838921.1 CDS S3705 NC_004741.1 3596324 3596599 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3596324..3596599) Shigella flexneri 2a str. 2457T 1079920 NP_838922.1 CDS S3707 NC_004741.1 3597087 3598301 R residues 1 to 404 of 404 are 90.59 pct identical to residues 1 to 404 of 404 from Escherichia coli K-12 : B1581; sensor protein complement(3597087..3598301) Shigella flexneri 2a str. 2457T 1079921 NP_838923.1 CDS S3708 NC_004741.1 3598709 3600037 R residues 1 to 442 of 442 are 99.54 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf complement(3598709..3600037) Shigella flexneri 2a str. 2457T 1077001 NP_838924.1 CDS argH NC_004741.1 3600239 3601612 R catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase complement(3600239..3601612) Shigella flexneri 2a str. 2457T 1079922 NP_838925.1 CDS argB NC_004741.1 3601673 3602446 R catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase complement(3601673..3602446) Shigella flexneri 2a str. 2457T 1079923 NP_838926.1 CDS argC NC_004741.1 3602457 3603461 R catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase complement(3602457..3603461) Shigella flexneri 2a str. 2457T 1079925 NP_838927.1 CDS argE NC_004741.1 3603615 3604766 D catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 3603615..3604766 Shigella flexneri 2a str. 2457T 1079926 NP_838928.1 CDS ppc NC_004741.1 3605118 3607769 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 3605118..3607769 Shigella flexneri 2a str. 2457T 1079927 NP_838929.1 CDS yijP NC_004741.1 3607952 3609685 D residues 1 to 577 of 577 are 94.80 pct identical to residues 1 to 577 of 577 from Escherichia coli K-12 : B3955; hypothetical protein 3607952..3609685 Shigella flexneri 2a str. 2457T 1079928 NP_838930.1 CDS yijO NC_004741.1 3609834 3610685 D residues 1 to 283 of 283 are 98.58 pct identical to residues 1 to 283 of 283 from Escherichia coli K-12 : B3954; ARAC-type regulatory protein 3609834..3610685 Shigella flexneri 2a str. 2457T 1079929 NP_838931.1 CDS frwD NC_004741.1 3610672 3611013 R FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; fructose-like phosphotransferase EIIB subunit 3 complement(3610672..3611013) Shigella flexneri 2a str. 2457T 1079930 NP_838932.1 CDS pflC NC_004741.1 3611015 3611893 R residues 1 to 292 of 292 are 94.86 pct identical to residues 1 to 292 of 292 from Escherichia coli K-12 : B3952; pyruvate formate lyase II activase complement(3611015..3611893) Shigella flexneri 2a str. 2457T 1079931 NP_838933.1 CDS pflD NC_004741.1 3611859 3614156 R involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 complement(3611859..3614156) Shigella flexneri 2a str. 2457T 1079982 NP_838934.1 CDS frwB NC_004741.1 3614207 3614527 R FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; fructose-like phosphotransferase EIIB subunit 2 complement(3614207..3614527) Shigella flexneri 2a str. 2457T 1079932 NP_838935.1 CDS frwC NC_004741.1 3614542 3615621 R FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; fructose-like permease EIIC subunit 2 complement(3614542..3615621) Shigella flexneri 2a str. 2457T 1079933 NP_838936.1 CDS katG NC_004741.1 3622125 3624305 R residues 1 to 726 of 726 are 96.28 pct identical to residues 1 to 726 of 726 from Escherichia coli K-12 : B3942; catalase; hydroperoxidase HPI(I) complement(3622125..3624305) Shigella flexneri 2a str. 2457T 1079940 NP_838937.1 CDS metF NC_004741.1 3624634 3625524 R MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase complement(3624634..3625524) Shigella flexneri 2a str. 2457T 1079941 NP_838938.1 CDS metL NC_004741.1 3625873 3628305 R multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II complement(3625873..3628305) Shigella flexneri 2a str. 2457T 1079942 NP_838939.1 CDS metB NC_004741.1 3628308 3629468 R catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase complement(3628308..3629468) Shigella flexneri 2a str. 2457T 1079943 NP_838940.1 CDS metJ NC_004741.1 3629745 3630062 D when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 3629745..3630062 Shigella flexneri 2a str. 2457T 1079944 NP_838941.1 CDS yiiX NC_004741.1 3630246 3630854 D member of the NlpC/P60 superfamily of peptidases; peptidoglycan peptidase 3630246..3630854 Shigella flexneri 2a str. 2457T 1079945 NP_838942.1 CDS rpmE NC_004741.1 3630915 3631127 R RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(3630915..3631127) Shigella flexneri 2a str. 2457T 1079946 NP_838943.1 CDS priA NC_004741.1 3631330 3633528 D binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 3631330..3633528 Shigella flexneri 2a str. 2457T 1079391 NP_838944.1 CDS cytR NC_004741.1 3633684 3634709 D negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 3633684..3634709 Shigella flexneri 2a str. 2457T 1080973 NP_838945.1 CDS ftsN NC_004741.1 3634801 3635760 D residues 1 to 319 of 319 are 76.48 pct identical to residues 1 to 319 of 319 from Escherichia coli K-12 : B3933; essential cell division protein FtsN 3634801..3635760 Shigella flexneri 2a str. 2457T 1079947 NP_838946.1 CDS hslV NC_004741.1 3635853 3636383 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 3635853..3636383 Shigella flexneri 2a str. 2457T 1079949 NP_838947.1 CDS hslU NC_004741.1 3636393 3637724 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 3636393..3637724 Shigella flexneri 2a str. 2457T 1079950 NP_838948.1 CDS menA NC_004741.1 3637791 3638717 D catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 3637791..3638717 Shigella flexneri 2a str. 2457T 1079951 NP_838949.1 CDS menG NC_004741.1 3638810 3639295 D regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 3638810..3639295 Shigella flexneri 2a str. 2457T 1078436 NP_838950.1 CDS yiiU NC_004741.1 3639380 3639625 R residues 1 to 81 of 81 are 100.00 pct identical to residues 1 to 81 of 81 from Escherichia coli K-12 : B3928; hypothetical protein complement(3639380..3639625) Shigella flexneri 2a str. 2457T 1079952 NP_838951.1 CDS glpF NC_004741.1 3640051 3640695 D residues 1 to 214 of 214 are 91.12 pct identical to residues 1 to 214 of 281 from Escherichia coli K-12 : B3927; glycerol diffusion facilitator protein 3640051..3640695 Shigella flexneri 2a str. 2457T 1079953 NP_838952.1 CDS glpK NC_004741.1 3640919 3642427 D Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 3640919..3642427 Shigella flexneri 2a str. 2457T 1079954 NP_838953.1 CDS glpX NC_004741.1 3642657 3643667 D type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 3642657..3643667 Shigella flexneri 2a str. 2457T 1079955 NP_838954.1 CDS fpr NC_004741.1 3643764 3644510 D residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 : B3924; ferredoxin-NADP reductase 3643764..3644510 Shigella flexneri 2a str. 2457T 1079956 NP_838955.1 CDS yiiT NC_004741.1 3644515 3644943 R with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD complement(3644515..3644943) Shigella flexneri 2a str. 2457T 1079957 NP_838956.1 CDS yiiS NC_004741.1 3644970 3645269 R residues 1 to 99 of 99 are 85.85 pct identical to residues 1 to 99 of 99 from Escherichia coli K-12 : B3922; hypothetical protein complement(3644970..3645269) Shigella flexneri 2a str. 2457T 1079958 NP_838957.1 CDS yiiQ NC_004741.1 3646022 3646621 D residues 1 to 199 of 199 are 95.97 pct identical to residues 1 to 199 of 199 from Escherichia coli K-12 : B3920; hypothetical protein 3646022..3646621 Shigella flexneri 2a str. 2457T 1079960 NP_838958.1 CDS tpiA NC_004741.1 3646729 3647496 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 3646729..3647496 Shigella flexneri 2a str. 2457T 1079961 NP_838959.1 CDS cdh NC_004741.1 3647551 3648306 R residues 1 to 251 of 251 are 90.83 pct identical to residues 1 to 251 of 251 from Escherichia coli K-12 : B3918; CDP-diacylglycerol pyrophosphatase complement(3647551..3648306) Shigella flexneri 2a str. 2457T 1079963 NP_838960.1 CDS sbp NC_004741.1 3648413 3649402 R residues 1 to 329 of 329 are 96.65 pct identical to residues 1 to 329 of 329 from Escherichia coli K-12 : B3917; sulfate transporter subunit complement(3648413..3649402) Shigella flexneri 2a str. 2457T 1079964 NP_838961.1 CDS pfkA NC_004741.1 3649722 3650666 R catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase complement(3649722..3650666) Shigella flexneri 2a str. 2457T 1079965 NP_838962.1 CDS fieF NC_004741.1 3650865 3651767 R member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F complement(3650865..3651767) Shigella flexneri 2a str. 2457T 1079966 NP_838963.2 CDS cpxP NC_004741.1 3651915 3652415 R repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP complement(3651915..3652415) Shigella flexneri 2a str. 2457T 1079967 NP_838964.1 CDS cpxR NC_004741.1 3652565 3653263 D response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 3652565..3653263 Shigella flexneri 2a str. 2457T 1079969 NP_838965.1 CDS cpxA NC_004741.1 3653260 3654633 D part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 3653260..3654633 Shigella flexneri 2a str. 2457T 1079971 NP_838966.1 CDS yiiM NC_004741.1 3654739 3655413 R residues 1 to 224 of 224 are 92.85 pct identical to residues 11 to 234 of 234 from Escherichia coli K-12 : B3910; hypothetical protein complement(3654739..3655413) Shigella flexneri 2a str. 2457T 1079973 NP_838967.2 CDS S3760 NC_004741.1 3655640 3656005 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3655640..3656005 Shigella flexneri 2a str. 2457T 1079974 NP_838968.2 CDS S3761 NC_004741.1 3655963 3656868 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3655963..3656868 Shigella flexneri 2a str. 2457T 1079975 NP_838969.1 CDS kdgT NC_004741.1 3656898 3657881 R transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease complement(3656898..3657881) Shigella flexneri 2a str. 2457T 1079976 NP_838970.1 CDS sodA NC_004741.1 3658141 3658761 R SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase complement(3658141..3658761) Shigella flexneri 2a str. 2457T 1079977 NP_838971.1 CDS rhaR NC_004741.1 3660077 3661015 R activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR complement(3660077..3661015) Shigella flexneri 2a str. 2457T 1079980 NP_838972.1 CDS rhaS NC_004741.1 3660999 3661835 R activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS complement(3660999..3661835) Shigella flexneri 2a str. 2457T 1079981 NP_838973.1 CDS rhaB NC_004741.1 3662123 3663592 D catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 3662123..3663592 Shigella flexneri 2a str. 2457T 1079984 NP_838974.1 CDS rhaA NC_004741.1 3663589 3664848 D catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 3663589..3664848 Shigella flexneri 2a str. 2457T 1079985 NP_838975.1 CDS rhaD NC_004741.1 3665273 3665914 D residues 1 to 213 of 213 are 99.06 pct identical to residues 62 to 274 of 274 from Escherichia coli K-12 : B3902; rhamnulose-1-phosphate aldolase 3665273..3665914 Shigella flexneri 2a str. 2457T 1079986 NP_838976.1 CDS yiiL NC_004741.1 3665924 3666238 D residues 1 to 104 of 104 are 99.03 pct identical to residues 1 to 104 of 104 from Escherichia coli K-12 : B3901; hypothetical protein 3665924..3666238 Shigella flexneri 2a str. 2457T 1079987 NP_838977.1 CDS frvA NC_004741.1 3666539 3666985 D with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; fructose-like phosphotransferase system subunit EIIA 3666539..3666985 Shigella flexneri 2a str. 2457T 1079988 NP_838978.1 CDS frvB NC_004741.1 3666996 3668447 D residues 1 to 483 of 483 are 94.20 pct identical to residues 3 to 485 of 485 from Escherichia coli K-12 : B3899; PTS transporter components IIBC 3666996..3668447 Shigella flexneri 2a str. 2457T 1079989 NP_838979.1 CDS frvX NC_004741.1 3668437 3669507 D with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; fructose-specific phosphotransferase system protein FrvX 3668437..3669507 Shigella flexneri 2a str. 2457T 1079990 NP_838980.1 CDS frvR NC_004741.1 3669507 3670157 D residues 1 to 210 of 216 are 95.23 pct identical to residues 1 to 210 of 582 from Escherichia coli K-12 : B3897; frv operon regulatory protein 3669507..3670157 Shigella flexneri 2a str. 2457T 1079991 NP_838981.1 CDS S3775 NC_004741.1 3670191 3670466 D residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3670191..3670466 Shigella flexneri 2a str. 2457T 1079992 NP_838982.1 CDS S3776 NC_004741.1 3670385 3670888 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18549.1|AF348706_238 (AF348706) iso-IS1 orfB [Shigella flexneri]; IS1 orfB 3670385..3670888 Shigella flexneri 2a str. 2457T 1079993 NP_838983.1 CDS fdhD NC_004741.1 3670960 3671793 R involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein complement(3670960..3671793) Shigella flexneri 2a str. 2457T 1080955 NP_838984.1 CDS fdoG NC_004741.1 3671987 3675037 D residues 1 to 1016 of 1016 are 99.61 pct identical to residues 1 to 1016 of 1016 from Escherichia coli K-12 : B3894; selenocysteine; formate dehydrogenase-O, major subunit 3671987..3675037 Shigella flexneri 2a str. 2457T 1080965 NP_838985.1 CDS fdoH NC_004741.1 3675050 3675952 D residues 1 to 284 of 300 are 96.12 pct identical to residues 1 to 284 of 300 from Escherichia coli K-12 : B3893; formate dehydrogenase-O, iron-sulfur subunit 3675050..3675952 Shigella flexneri 2a str. 2457T 1079994 NP_838986.1 CDS fdoI NC_004741.1 3675949 3676584 D cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 3675949..3676584 Shigella flexneri 2a str. 2457T 1079995 NP_838987.1 CDS fdhE NC_004741.1 3676581 3677510 D required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 3676581..3677510 Shigella flexneri 2a str. 2457T 1080020 NP_838988.1 CDS yiiF NC_004741.1 3677840 3678082 R residues 1 to 80 of 80 are 100.00 pct identical to residues 1 to 80 of 80 from Escherichia coli K-12 : B3890; hypothetical protein complement(3677840..3678082) Shigella flexneri 2a str. 2457T 1079996 NP_838989.1 CDS yiiE NC_004741.1 3678300 3678545 R residues 1 to 81 of 81 are 98.76 pct identical to residues 1 to 81 of 81 from Escherichia coli K-12 : B3889; hypothetical protein complement(3678300..3678545) Shigella flexneri 2a str. 2457T 1079997 NP_838990.1 CDS S4827 NC_004741.1 3679197 3680342 R residues 78 to 381 of 381 are 94.73 pct identical to residues 1 to 304 of 304 from NRprotein_Feb03 : >ref|NP_290516.1| Z5429 gene product [Escherichia coli O157:H7 EDL933] ref|NP_312840.1| hypothetical protein [Escherichia coli O157:H7] pir||D86077 hypothetical protein Z5429 [imported] - Escherichia coli (strain O157:H7, substrain EDL933) pir||E91230 hypothetical protein ECs4813 [imported] - Escher; hypothetical protein complement(3679197..3680342) Shigella flexneri 2a str. 2457T 1079998 NP_838991.1 CDS S4828 NC_004741.1 3680500 3680751 R residues 1 to 75 of 83 are 97.33 pct identical to residues 121 to 195 of 330 from NRprotein_Feb03 : >ref|NP_290515.1| Z5428 gene product [Escherichia coli O157:H7 EDL933] pir||C86077 hypothetical protein Z5428 [imported] - Escherichia coli (strain O157:H7, substrain EDL933) gb|AAG59079.1|AE005620_1 Z5428 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein complement(3680500..3680751) Shigella flexneri 2a str. 2457T 1079999 NP_838992.1 CDS S3784 NC_004741.1 3680897 3681172 D residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3680897..3681172 Shigella flexneri 2a str. 2457T 1080000 NP_838993.1 CDS S3785 NC_004741.1 3681091 3681594 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3681091..3681594 Shigella flexneri 2a str. 2457T 1080001 NP_838994.1 CDS yiiD NC_004741.1 3682136 3683125 R residues 1 to 329 of 329 are 99.08 pct identical to residues 1 to 329 of 329 from Escherichia coli K-12 : B3888; acetyltransferase complement(3682136..3683125) Shigella flexneri 2a str. 2457T 1080936 NP_838995.1 CDS yihZ NC_004741.1 3683122 3683559 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(3683122..3683559) Shigella flexneri 2a str. 2457T 1080002 NP_838996.1 CDS rbn NC_004741.1 3683556 3684428 R RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN complement(3683556..3684428) Shigella flexneri 2a str. 2457T 1080003 NP_838997.1 CDS yihX NC_004741.1 3684422 3685021 R residues 1 to 199 of 199 are 100.00 pct identical to residues 8 to 206 of 206 from Escherichia coli K-12 : B3885; phosphatase complement(3684422..3685021) Shigella flexneri 2a str. 2457T 1080004 NP_838998.1 CDS yihW NC_004741.1 3685120 3685905 R residues 1 to 261 of 261 are 99.61 pct identical to residues 9 to 269 of 269 from Escherichia coli K-12 : B3884; DEOR-type transcriptional regulator complement(3685120..3685905) Shigella flexneri 2a str. 2457T 1080005 NP_838999.1 CDS yihV NC_004741.1 3685939 3686835 R residues 1 to 298 of 298 are 89.93 pct identical to residues 3 to 300 of 300 from Escherichia coli K-12 : B3883; kinase complement(3685939..3686835) Shigella flexneri 2a str. 2457T 1080006 NP_839000.1 CDS yihU NC_004741.1 3687003 3687899 D residues 1 to 298 of 298 are 90.60 pct identical to residues 1 to 298 of 298 from Escherichia coli K-12 : B3882; dehydrogenase 3687003..3687899 Shigella flexneri 2a str. 2457T 1080007 NP_839001.1 CDS yihT NC_004741.1 3687923 3688801 D residues 1 to 292 of 292 are 94.17 pct identical to residues 1 to 292 of 292 from Escherichia coli K-12 : B3881; aldolase 3687923..3688801 Shigella flexneri 2a str. 2457T 1080008 NP_839002.1 CDS yihS NC_004741.1 3688818 3690059 D residues 1 to 413 of 413 are 99.51 pct identical to residues 6 to 418 of 418 from Escherichia coli K-12 : B3880; hypothetical protein 3688818..3690059 Shigella flexneri 2a str. 2457T 1080009 NP_839003.1 CDS yihR NC_004741.1 3690197 3691099 D residues 1 to 300 of 300 are 98.66 pct identical to residues 9 to 308 of 308 from Escherichia coli K-12 : B3879; aldose-1-epimerase 3690197..3691099 Shigella flexneri 2a str. 2457T 1080010 NP_839004.1 CDS yihQ NC_004741.1 3691298 3693334 D residues 1 to 678 of 678 are 97.49 pct identical to residues 1 to 678 of 678 from Escherichia coli K-12 : B3878; alpha-glucosidase 3691298..3693334 Shigella flexneri 2a str. 2457T 1080011 NP_839005.1 CDS yihO NC_004741.1 3694797 3696200 D residues 1 to 462 of 467 are 98.70 pct identical to residues 3 to 464 of 487 from Escherichia coli K-12 : B3876; permease 3694797..3696200 Shigella flexneri 2a str. 2457T 1080013 NP_839006.1 CDS S3800 NC_004741.1 3696613 3697116 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(3696613..3697116) Shigella flexneri 2a str. 2457T 1080015 NP_839007.1 CDS S3801 NC_004741.1 3697035 3697310 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3697035..3697310) Shigella flexneri 2a str. 2457T 1080016 NP_839008.1 CDS yihN NC_004741.1 3697339 3698397 R residues 1 to 344 of 352 are 95.93 pct identical to residues 1 to 344 of 421 from Escherichia coli K-12 : B3874; resistance protein complement(3697339..3698397) Shigella flexneri 2a str. 2457T 1080017 NP_839009.1 CDS yihM NC_004741.1 3698499 3699479 R residues 1 to 326 of 326 are 99.07 pct identical to residues 1 to 326 of 326 from Escherichia coli K-12 : B3873; hypothetical protein complement(3698499..3699479) Shigella flexneri 2a str. 2457T 1080018 NP_839010.1 CDS yihL NC_004741.1 3699487 3700197 R residues 1 to 236 of 236 are 100.00 pct identical to residues 1 to 236 of 236 from Escherichia coli K-12 : B3872; transcriptional regulator complement(3699487..3700197) Shigella flexneri 2a str. 2457T 1080019 NP_839011.1 CDS yihK NC_004741.1 3700414 3702237 R residues 1 to 591 of 607 are 94.92 pct identical to residues 1 to 591 of 591 from Escherichia coli K-12 : B3871; GTP-binding protein complement(3700414..3702237) Shigella flexneri 2a str. 2457T 1080929 NP_839012.1 CDS glnA NC_004741.1 3702610 3704019 D forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 3702610..3704019 Shigella flexneri 2a str. 2457T 1080021 NP_839013.1 CDS glnL NC_004741.1 3704192 3705241 D sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 3704192..3705241 Shigella flexneri 2a str. 2457T 1080022 NP_839014.1 CDS glnG NC_004741.1 3705253 3706662 D response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 3705253..3706662 Shigella flexneri 2a str. 2457T 1080023 NP_839015.1 CDS hemN NC_004741.1 3707113 3708486 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(3707113..3708486) Shigella flexneri 2a str. 2457T 1080024 NP_839016.1 CDS yihI NC_004741.1 3708675 3709184 R residues 1 to 169 of 169 are 78.69 pct identical to residues 1 to 169 of 169 from Escherichia coli K-12 : B3866; hypothetical protein complement(3708675..3709184) Shigella flexneri 2a str. 2457T 1080025 NP_839017.2 CDS engB NC_004741.1 3709766 3710398 D binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 3709766..3710398 Shigella flexneri 2a str. 2457T 1080026 NP_839018.1 CDS polA NC_004741.1 3710780 3713566 R has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I complement(3710780..3713566) Shigella flexneri 2a str. 2457T 1080028 NP_839019.1 CDS yihG NC_004741.1 3713930 3714862 D residues 1 to 310 of 310 are 91.93 pct identical to residues 1 to 310 of 310 from Escherichia coli K-12 : B3862; acyltransferase 3713930..3714862 Shigella flexneri 2a str. 2457T 1080029 NP_839020.1 CDS yihF NC_004741.1 3714903 3716375 R residues 1 to 490 of 490 are 97.14 pct identical to residues 1 to 490 of 490 from Escherichia coli K-12 : B3861; hypothetical protein complement(3714903..3716375) Shigella flexneri 2a str. 2457T 1080030 NP_839021.1 CDS dsbA NC_004741.1 3716488 3717114 R residues 1 to 208 of 208 are 99.51 pct identical to residues 1 to 208 of 208 from Escherichia coli K-12 : B3860; essential for cytochrome c synthesis and formate-dependent reduction; periplasmic protein disulfide isomerase I complement(3716488..3717114) Shigella flexneri 2a str. 2457T 1080031 NP_839022.1 CDS yihE NC_004741.1 3717131 3718117 R catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase complement(3717131..3718117) Shigella flexneri 2a str. 2457T 1080032 NP_839023.1 CDS yihD NC_004741.1 3718194 3718463 R residues 1 to 89 of 89 are 98.87 pct identical to residues 1 to 89 of 89 from Escherichia coli K-12 : B3858; hypothetical protein complement(3718194..3718463) Shigella flexneri 2a str. 2457T 1080033 NP_839024.1 CDS mobA NC_004741.1 3718533 3719117 D Links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A 3718533..3719117 Shigella flexneri 2a str. 2457T 1080034 NP_839025.1 CDS mobB NC_004741.1 3719099 3719626 D residues 6 to 175 of 175 are 98.82 pct identical to residues 1 to 170 of 170 from Escherichia coli K-12 : B3856; molybdopterin-guanine dinucleotide biosynthesis protein B 3719099..3719626 Shigella flexneri 2a str. 2457T 1080035 NP_839026.1 CDS hemG NC_004741.1 3725208 3725753 R catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase complement(3725208..3725753) Shigella flexneri 2a str. 2457T 1080042 NP_839027.1 CDS trkH NC_004741.1 3725765 3727216 R residues 1 to 417 of 483 are 93.28 pct identical to residues 1 to 417 of 432 from Escherichia coli K-12 : B3849; requires trkE; potassium transporter complement(3725765..3727216) Shigella flexneri 2a str. 2457T 1080043 NP_839028.1 CDS yigZ NC_004741.1 3727255 3727869 R residues 1 to 204 of 204 are 94.60 pct identical to residues 2 to 205 of 205 from Escherichia coli K-12 : B3848; hypothetical protein complement(3727255..3727869) Shigella flexneri 2a str. 2457T 1080044 NP_839029.1 CDS pepQ NC_004741.1 3727869 3729200 R catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase complement(3727869..3729200) Shigella flexneri 2a str. 2457T 1080045 NP_839030.1 CDS fadB NC_004741.1 3729390 3731579 D includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 3729390..3731579 Shigella flexneri 2a str. 2457T 1080046 NP_839031.1 CDS fadA NC_004741.1 3731589 3732752 D FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 3731589..3732752 Shigella flexneri 2a str. 2457T 1080047 NP_839032.1 CDS fre NC_004741.1 3732944 3733645 R NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase complement(3732944..3733645) Shigella flexneri 2a str. 2457T 1080048 NP_839033.1 CDS yigC NC_004741.1 3733691 3735184 R catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(3733691..3735184) Shigella flexneri 2a str. 2457T 1080049 NP_839034.1 CDS rfaH NC_004741.1 3735351 3735839 D residues 1 to 162 of 162 are 98.76 pct identical to residues 1 to 162 of 162 from Escherichia coli K-12 : B3842; affects biosynthesis of lipopolysaccharide core, F pilin, and hemolysin; transcriptional activator RfaH 3735351..3735839 Shigella flexneri 2a str. 2457T 1080050 NP_839035.1 CDS yigW NC_004741.1 3735836 3736618 R magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD complement(3735836..3736618) Shigella flexneri 2a str. 2457T 1080051 NP_839036.1 CDS yigU NC_004741.1 3736660 3737436 R with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC complement(3736660..3737436) Shigella flexneri 2a str. 2457T 1080052 NP_839037.1 CDS S3838 NC_004741.1 3737439 3737954 R mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase complement(3737439..3737954) Shigella flexneri 2a str. 2457T 1080053 NP_839038.1 CDS tatA NC_004741.1 3737958 3738269 R TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase A complement(3737958..3738269) Shigella flexneri 2a str. 2457T 1080055 NP_839039.1 CDS ubiB NC_004741.1 3738306 3739946 R an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB complement(3738306..3739946) Shigella flexneri 2a str. 2457T 1080056 NP_839040.1 CDS yigP NC_004741.1 3739943 3740548 R residues 1 to 201 of 201 are 100.00 pct identical to residues 1 to 201 of 201 from Escherichia coli K-12 : B3834; hypothetical protein complement(3739943..3740548) Shigella flexneri 2a str. 2457T 1080057 NP_839041.1 CDS ubiE NC_004741.1 3740562 3741317 R Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase complement(3740562..3741317) Shigella flexneri 2a str. 2457T 1080058 NP_839042.1 CDS yigN NC_004741.1 3741412 3742824 R YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC complement(3741412..3742824) Shigella flexneri 2a str. 2457T 1080059 NP_839043.1 CDS udp NC_004741.1 3742980 3743741 R catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase complement(3742980..3743741) Shigella flexneri 2a str. 2457T 1080060 NP_839044.1 CDS S3847 NC_004741.1 3744111 3744419 R no significant similarities; hypothetical protein complement(3744111..3744419) Shigella flexneri 2a str. 2457T 1080062 NP_839045.1 CDS metE NC_004741.1 3744856 3747117 R catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase complement(3744856..3747117) Shigella flexneri 2a str. 2457T 1080063 NP_839046.1 CDS metR NC_004741.1 3747353 3748306 D residues 1 to 317 of 317 are 94.95 pct identical to residues 1 to 317 of 317 from Escherichia coli K-12 : B3828; regulator for metE and metH 3747353..3748306 Shigella flexneri 2a str. 2457T 1080064 NP_839047.1 CDS yigM NC_004741.1 3748194 3749093 R residues 1 to 299 of 299 are 94.64 pct identical to residues 1 to 299 of 299 from Escherichia coli K-12 : B3827; hypothetical protein complement(3748194..3749093) Shigella flexneri 2a str. 2457T 1080065 NP_839048.1 CDS yigL NC_004741.1 3749169 3749969 R purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase complement(3749169..3749969) Shigella flexneri 2a str. 2457T 1080066 NP_839049.1 CDS pldB NC_004741.1 3749977 3750999 R lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 complement(3749977..3750999) Shigella flexneri 2a str. 2457T 1080067 NP_839050.1 CDS yigK NC_004741.1 3751314 3751730 D residues 1 to 138 of 138 are 87.68 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 : B3824; hypothetical protein 3751314..3751730 Shigella flexneri 2a str. 2457T 1080068 NP_839051.1 CDS yigJ NC_004741.1 3751792 3752160 R residues 1 to 122 of 122 are 90.16 pct identical to residues 1 to 122 of 122 from Escherichia coli K-12 : B3823; hypothetical protein complement(3751792..3752160) Shigella flexneri 2a str. 2457T 1080069 NP_839052.1 CDS recQ NC_004741.1 3752476 3754311 R functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ complement(3752476..3754311) Shigella flexneri 2a str. 2457T 1080071 NP_839053.1 CDS pldA NC_004741.1 3754438 3755307 R catalyzes the hydrolysis of phosphatidylcholine; phospholipase A complement(3754438..3755307) Shigella flexneri 2a str. 2457T 1080073 NP_839054.2 CDS yigI NC_004741.1 3755472 3755939 D residues 1 to 161 of 161 are 100.00 pct identical to residues 1 to 161 of 161 from Escherichia coli K-12 : B3820; hypothetical protein 3755472..3755939 Shigella flexneri 2a str. 2457T 1080074 NP_839055.1 CDS rarD NC_004741.1 3755991 3756881 D residues 4 to 296 of 296 are 92.49 pct identical to residues 8 to 300 of 300 from Escherichia coli K-12 : B3819; hypothetical protein 3755991..3756881 Shigella flexneri 2a str. 2457T 1080076 NP_839056.1 CDS yigG NC_004741.1 3756940 3757356 D residues 1 to 138 of 138 are 82.60 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 : B3818; hypothetical protein 3756940..3757356 Shigella flexneri 2a str. 2457T 1080079 NP_839057.1 CDS yigF NC_004741.1 3757370 3757750 D residues 1 to 126 of 126 are 99.20 pct identical to residues 1 to 126 of 126 from Escherichia coli K-12 : B3817; hypothetical protein 3757370..3757750 Shigella flexneri 2a str. 2457T 1080080 NP_839058.1 CDS corA NC_004741.1 3757791 3758741 R responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA complement(3757791..3758741) Shigella flexneri 2a str. 2457T 1078848 NP_839059.1 CDS yigE NC_004741.1 3759111 3759449 D residues 1 to 112 of 112 are 98.21 pct identical to residues 1 to 112 of 161 from Escherichia coli K-12 : B3815; hypothetical protein 3759111..3759449 Shigella flexneri 2a str. 2457T 1076670 NP_839060.1 CDS S3863 NC_004741.1 3759460 3760788 R residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf complement(3759460..3760788) Shigella flexneri 2a str. 2457T 1080082 NP_839061.1 CDS S3864 NC_004741.1 3761014 3761313 D residues 1 to 99 of 99 are 97.97 pct identical to residues 1 to 99 of 99 from Escherichia coli K-12 : B3814; hypothetical protein 3761014..3761313 Shigella flexneri 2a str. 2457T 1080083 NP_839062.1 CDS uvrD NC_004741.1 3761460 3763622 R unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II complement(3761460..3763622) Shigella flexneri 2a str. 2457T 1076646 NP_839063.1 CDS yigB NC_004741.1 3763706 3764422 R YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase complement(3763706..3764422) Shigella flexneri 2a str. 2457T 1080084 NP_839064.1 CDS xerC NC_004741.1 3764422 3765318 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC complement(3764422..3765318) Shigella flexneri 2a str. 2457T 1080085 NP_839065.1 CDS yigA NC_004741.1 3765315 3766022 R residues 1 to 235 of 235 are 95.74 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B3810; hypothetical protein complement(3765315..3766022) Shigella flexneri 2a str. 2457T 1080086 NP_839066.2 CDS dapF NC_004741.1 3766019 3766843 R involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase complement(3766019..3766843) Shigella flexneri 2a str. 2457T 1080088 NP_839067.1 CDS yifL NC_004741.1 3766880 3767083 R residues 1 to 67 of 67 are 100.00 pct identical to residues 1 to 67 of 67 from GenPept : >gb|AAG59001.1|AE005612_4 (AE005612) Z5325 gene product [Escherichia coli O157:H7 EDL933]; outer membrane lipoprotein complement(3766880..3767083) Shigella flexneri 2a str. 2457T 1080089 NP_839068.1 CDS S3871 NC_004741.1 3767386 3768423 D residues 1 to 342 of 345 are 69.59 pct identical to residues 39 to 380 of 669 from GenPept : >emb|CAD09375.1| (AL627279) possible exported protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 3767386..3768423 Shigella flexneri 2a str. 2457T 1080090 NP_839069.1 CDS S3874 NC_004741.1 3769659 3770162 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS1 orfB complement(3769659..3770162) Shigella flexneri 2a str. 2457T 1080092 NP_839070.1 CDS S3875 NC_004741.1 3770081 3770356 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3770081..3770356) Shigella flexneri 2a str. 2457T 1080093 NP_839071.1 CDS cyaY NC_004741.1 3770885 3771205 D defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 3770885..3771205 Shigella flexneri 2a str. 2457T 1080095 NP_839072.1 CDS cyaA NC_004741.1 3771245 3773791 R catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase complement(3771245..3773791) Shigella flexneri 2a str. 2457T 1080096 NP_839073.1 CDS hemC NC_004741.1 3774178 3775119 D transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 3774178..3775119 Shigella flexneri 2a str. 2457T 1080097 NP_839074.1 CDS hemD NC_004741.1 3775116 3775856 D catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 3775116..3775856 Shigella flexneri 2a str. 2457T 1080098 NP_839075.1 CDS hemX NC_004741.1 3775878 3777077 D residues 1 to 367 of 399 are 88.01 pct identical to residues 1 to 367 of 393 from Escherichia coli K-12 : B3803; uroporphyrinogen III C-methyltransferase 3775878..3777077 Shigella flexneri 2a str. 2457T 1080099 NP_839076.1 CDS hemY NC_004741.1 3777080 3778276 D residues 19 to 398 of 398 are 92.63 pct identical to residues 19 to 398 of 398 from Escherichia coli K-12 : B3802; involved in late step of protohemeiX synthesis; protoheme IX biogenesis protein 3777080..3778276 Shigella flexneri 2a str. 2457T 1080100 NP_839077.2 CDS S3883 NC_004741.1 3779138 3779503 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3779138..3779503 Shigella flexneri 2a str. 2457T 1080101 NP_839078.2 CDS S3884 NC_004741.1 3779461 3780366 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3779461..3780366 Shigella flexneri 2a str. 2457T 1080102 NP_839079.1 CDS aslB NC_004741.1 3780536 3781771 R residues 1 to 411 of 411 are 96.10 pct identical to residues 1 to 411 of 411 from Escherichia coli K-12 : B3800; arylsulfatase regulator complement(3780536..3781771) Shigella flexneri 2a str. 2457T 1080103 NP_839080.1 CDS yifK NC_004741.1 3782457 3783842 R uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transporter complement(3782457..3783842) Shigella flexneri 2a str. 2457T 1080109 NP_839081.1 CDS wecG NC_004741.1 3784033 3784773 R residues 1 to 246 of 246 are 99.18 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B3794; required for synthesis of enterobacterial common antigen (ECA); UDP-N-acetyl-D-mannosaminuronic acid transferase complement(3784033..3784773) Shigella flexneri 2a str. 2457T 1080110 NP_839082.1 CDS wecF NC_004741.1 3784776 3786128 R enterobacterial common antigen polymerase; common antigen polymerase complement(3784776..3786128) Shigella flexneri 2a str. 2457T 1080111 NP_839083.1 CDS yifM NC_004741.1 3786125 3787204 R catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase complement(3786125..3787204) Shigella flexneri 2a str. 2457T 1080112 NP_839084.1 CDS wzxE NC_004741.1 3787201 3788451 R residues 1 to 416 of 416 are 91.34 pct identical to residues 1 to 416 of 416 from Escherichia coli K-12 : B3792; cytochrome complement(3787201..3788451) Shigella flexneri 2a str. 2457T 1080113 NP_839085.1 CDS wecE NC_004741.1 3788453 3789583 R catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase complement(3788453..3789583) Shigella flexneri 2a str. 2457T 1080114 NP_839086.1 CDS wecD NC_004741.1 3789588 3790133 R residues 1 to 181 of 181 are 81.76 pct identical to residues 1 to 181 of 181 from Escherichia coli K-12 : B3790; TDP-fucosamine acetyltransferase complement(3789588..3790133) Shigella flexneri 2a str. 2457T 1080115 NP_839087.1 CDS rffH NC_004741.1 3790240 3791121 R residues 1 to 293 of 293 are 100.00 pct identical to residues 1 to 293 of 293 from Escherichia coli K-12 : B3789; glucose-1-phosphate thymidylyltransferase complement(3790240..3791121) Shigella flexneri 2a str. 2457T 1080116 NP_839088.1 CDS rffG NC_004741.1 3791140 3792207 R residues 1 to 355 of 355 are 94.08 pct identical to residues 1 to 355 of 355 from Escherichia coli K-12 : B3788; dTDP-glucose 4,6-dehydratase complement(3791140..3792207) Shigella flexneri 2a str. 2457T 1080117 NP_839089.1 CDS wecC NC_004741.1 3792207 3793469 R catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase complement(3792207..3793469) Shigella flexneri 2a str. 2457T 1080118 NP_839090.1 CDS wecB NC_004741.1 3793466 3794638 R residues 1 to 390 of 390 are 96.15 pct identical to residues 1 to 389 of 389 from Escherichia coli K-12 : B3786; required for synthesis of enterobacterial common antigen (ECA); UDP-N-acetyl glucosamine-2-epimerase complement(3793466..3794638) Shigella flexneri 2a str. 2457T 1080119 NP_839091.1 CDS wzzE NC_004741.1 3794652 3795698 R Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE complement(3794652..3795698) Shigella flexneri 2a str. 2457T 1080120 NP_839092.1 CDS rfe NC_004741.1 3795710 3796813 R residues 1 to 367 of 367 are 88.82 pct identical to residues 1 to 367 of 367 from Escherichia coli K-12 : B3784; required for synthesis of enterobacterial common antigen (ECA); UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase complement(3795710..3796813) Shigella flexneri 2a str. 2457T 1080962 NP_839093.1 CDS rho NC_004741.1 3797053 3798312 R An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho complement(3797053..3798312) Shigella flexneri 2a str. 2457T 1076538 NP_839094.1 CDS rhoL NC_004741.1 3798397 3798498 R residues 1 to 33 of 33 are 100.00 pct identical to residues 1 to 33 of 33 from Escherichia coli K-12 : B3782; rho operon leader peptide complement(3798397..3798498) Shigella flexneri 2a str. 2457T 1080121 NP_839095.1 CDS trxA NC_004741.1 3798639 3799022 R residues 1 to 127 of 127 are 100.00 pct identical to residues 1 to 127 of 127 from Escherichia coli K-12 : B3781; thioredoxin complement(3798639..3799022) Shigella flexneri 2a str. 2457T 1080923 NP_839096.1 CDS rhlB NC_004741.1 3799099 3800364 D enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 3799099..3800364 Shigella flexneri 2a str. 2457T 1080968 NP_839097.1 CDS gppA NC_004741.1 3800498 3801982 D catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 3800498..3801982 Shigella flexneri 2a str. 2457T 1080122 NP_839098.1 CDS rep NC_004741.1 3802029 3804050 R single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep complement(3802029..3804050) Shigella flexneri 2a str. 2457T 1080106 NP_839099.1 CDS ppiC NC_004741.1 3804137 3804418 D residues 1 to 93 of 93 are 98.92 pct identical to residues 1 to 93 of 93 from Escherichia coli K-12 : B3775; peptidyl-prolyl cis-trans isomerase C (rotamase C) 3804137..3804418 Shigella flexneri 2a str. 2457T 1080123 NP_839100.1 CDS ilvC NC_004741.1 3804464 3805939 R catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase complement(3804464..3805939) Shigella flexneri 2a str. 2457T 1080124 NP_839101.1 CDS ilvY NC_004741.1 3806089 3806979 D participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 3806089..3806979 Shigella flexneri 2a str. 2457T 1080125 NP_839102.1 CDS ilvA NC_004741.1 3806976 3808520 R threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase complement(3806976..3808520) Shigella flexneri 2a str. 2457T 1080126 NP_839103.1 CDS ilvD NC_004741.1 3808523 3810373 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(3808523..3810373) Shigella flexneri 2a str. 2457T 1080127 NP_839104.1 CDS ilvE NC_004741.1 3810438 3811367 R catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase complement(3810438..3811367) Shigella flexneri 2a str. 2457T 1080128 NP_839105.1 CDS ilvM NC_004741.1 3811387 3811647 R residues 1 to 86 of 86 are 100.00 pct identical to residues 2 to 87 of 87 from Escherichia coli K-12 : B3769; valine insensitive; acetolactate synthase 2 regulatory subunit complement(3811387..3811647) Shigella flexneri 2a str. 2457T 1080129 NP_839106.1 CDS ilvG NC_004741.1 3811647 3813293 R catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit complement(3811647..3813293) Shigella flexneri 2a str. 2457T 1080130 NP_839107.1 CDS ilvL NC_004741.1 3813432 3813530 R residues 1 to 32 of 32 are 56.25 pct identical to residues 1 to 32 of 32 from Escherichia coli K-12 : B3766; ilvG operon leader peptide complement(3813432..3813530) Shigella flexneri 2a str. 2457T 1080131 NP_839108.1 CDS yifE NC_004741.1 3815386 3815724 R residues 1 to 112 of 112 are 100.00 pct identical to residues 1 to 112 of 112 from Escherichia coli K-12 : B3764; hypothetical protein complement(3815386..3815724) Shigella flexneri 2a str. 2457T 1080133 NP_839109.1 CDS yifA NC_004741.1 3815843 3816682 D Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 3815843..3816682 Shigella flexneri 2a str. 2457T 1080134 NP_839110.1 CDS yieP NC_004741.1 3822630 3823178 D residues 1 to 182 of 182 are 98.90 pct identical to residues 1 to 181 of 181 from Escherichia coli K-12 : B3755; hypothetical protein 3822630..3823178 Shigella flexneri 2a str. 2457T 1080142 NP_839111.1 CDS yieO NC_004741.1 3823225 3824628 D residues 1 to 467 of 467 are 92.07 pct identical to residues 9 to 475 of 475 from Escherichia coli K-12 : B3754; transporter 3823225..3824628 Shigella flexneri 2a str. 2457T 1080144 NP_839112.1 CDS rbsR NC_004741.1 3824594 3825577 R DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR complement(3824594..3825577) Shigella flexneri 2a str. 2457T 1080145 NP_839113.1 CDS rbsK NC_004741.1 3825590 3826534 R catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase complement(3825590..3826534) Shigella flexneri 2a str. 2457T 1080146 NP_839114.1 CDS rbsC NC_004741.1 3827560 3828525 R functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease complement(3827560..3828525) Shigella flexneri 2a str. 2457T 1080148 NP_839115.1 CDS S3936 NC_004741.1 3829707 3830210 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(3829707..3830210) Shigella flexneri 2a str. 2457T 1080149 NP_839116.1 CDS S3937 NC_004741.1 3830129 3830404 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3830129..3830404) Shigella flexneri 2a str. 2457T 1080150 NP_839117.1 CDS rbsD NC_004741.1 3830819 3831238 R cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase complement(3830819..3831238) Shigella flexneri 2a str. 2457T 1080152 NP_839118.1 CDS trkD NC_004741.1 3831405 3833273 R Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup complement(3831405..3833273) Shigella flexneri 2a str. 2457T 1080153 NP_839119.1 CDS S3941 NC_004741.1 3833431 3834759 R residues 1 to 442 of 442 are 100.00 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf complement(3833431..3834759) Shigella flexneri 2a str. 2457T 1080154 NP_839120.2 CDS yieN NC_004741.1 3834933 3836429 D interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 3834933..3836429 Shigella flexneri 2a str. 2457T 1080155 NP_839121.2 CDS yieM NC_004741.1 3836423 3837874 D contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 3836423..3837874 Shigella flexneri 2a str. 2457T 1080156 NP_839122.1 CDS asnA NC_004741.1 3837879 3838871 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(3837879..3838871) Shigella flexneri 2a str. 2457T 1080157 NP_839123.1 CDS asnC NC_004741.1 3839023 3839481 D transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 3839023..3839481 Shigella flexneri 2a str. 2457T 1080158 NP_839124.1 CDS mioC NC_004741.1 3839571 3840014 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 3839571..3840014 Shigella flexneri 2a str. 2457T 1080159 NP_839125.1 CDS gidA NC_004741.1 3840393 3842282 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 3840393..3842282 Shigella flexneri 2a str. 2457T 1080161 NP_839126.1 CDS gidB NC_004741.1 3842346 3842969 D glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 3842346..3842969 Shigella flexneri 2a str. 2457T 1080162 NP_839127.2 CDS atpI NC_004741.1 3843586 3843966 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 3843586..3843966 Shigella flexneri 2a str. 2457T 1080163 NP_839128.1 CDS atpB NC_004741.1 3843975 3844790 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 3843975..3844790 Shigella flexneri 2a str. 2457T 1080164 NP_839129.1 CDS atpE NC_004741.1 3844837 3845076 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 3844837..3845076 Shigella flexneri 2a str. 2457T 1080165 NP_839130.1 CDS atpF NC_004741.1 3845138 3845608 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 3845138..3845608 Shigella flexneri 2a str. 2457T 1080166 NP_839131.1 CDS atpH NC_004741.1 3845623 3846156 D Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 3845623..3846156 Shigella flexneri 2a str. 2457T 1080167 NP_839132.1 CDS atpA NC_004741.1 3846169 3847710 D produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 3846169..3847710 Shigella flexneri 2a str. 2457T 1080168 NP_839133.1 CDS atpG NC_004741.1 3847761 3848624 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 3847761..3848624 Shigella flexneri 2a str. 2457T 1080169 NP_839134.1 CDS atpD NC_004741.1 3848651 3850033 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 3848651..3850033 Shigella flexneri 2a str. 2457T 1080170 NP_839135.1 CDS atpC NC_004741.1 3850060 3850473 D part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 3850060..3850473 Shigella flexneri 2a str. 2457T 1080171 NP_839136.1 CDS glmU NC_004741.1 3850824 3852194 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 3850824..3852194 Shigella flexneri 2a str. 2457T 1080172 NP_839137.1 CDS glmS NC_004741.1 3852356 3854185 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 3852356..3854185 Shigella flexneri 2a str. 2457T 1080173 NP_839138.1 CDS S3960 NC_004741.1 3854306 3855634 D residues 1 to 442 of 442 are 99.32 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 3854306..3855634 Shigella flexneri 2a str. 2457T 1080174 NP_839139.1 CDS lpfA NC_004741.1 3855926 3856498 D residues 1 to 190 of 190 are 92.10 pct identical to residues 1 to 190 of 190 from GenPept : >gb|AAL18161.1| (AY057066) LpfA [Escherichia coli]; major fimbrial subunit 3855926..3856498 Shigella flexneri 2a str. 2457T 1080175 NP_839140.2 CDS S3963 NC_004741.1 3857264 3858169 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(3857264..3858169) Shigella flexneri 2a str. 2457T 1080176 NP_839141.2 CDS S3964 NC_004741.1 3858127 3858492 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(3858127..3858492) Shigella flexneri 2a str. 2457T 1080177 NP_839142.1 CDS S3965 NC_004741.1 3860121 3860627 D residues 1 to 168 of 168 are 99.40 pct identical to residues 747 to 914 of 1295 from GenPept : >gb|AAG30168.1|AF289092_1 (AF289092) secreted autotransporter toxin [Escherichia coli]; partial; secreted autotransporter toxin 3860121..3860627 Shigella flexneri 2a str. 2457T 1080178 NP_839143.1 CDS S3966 NC_004741.1 3860668 3861381 R residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB complement(3860668..3861381) Shigella flexneri 2a str. 2457T 1080179 NP_839144.1 CDS S3967 NC_004741.1 3861522 3861824 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA complement(3861522..3861824) Shigella flexneri 2a str. 2457T 1080959 NP_839145.1 CDS S3968 NC_004741.1 3862079 3862372 D residues 1 to 97 of 97 are 87.62 pct identical to residues 24 to 120 of 120 from GenPept : >gb|AAG58857.1|AE005598_1 (AE005598) Z5148 gene product [Escherichia coli O157:H7 EDL933]; transporter 3862079..3862372 Shigella flexneri 2a str. 2457T 1080957 NP_839146.2 CDS nepI NC_004741.1 3862413 3863603 R experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter complement(3862413..3863603) Shigella flexneri 2a str. 2457T 1080180 NP_839147.1 CDS yicN NC_004741.1 3863814 3864293 R residues 1 to 159 of 159 are 98.74 pct identical to residues 1 to 159 of 159 from Escherichia coli K-12 : B3663; hypothetical protein complement(3863814..3864293) Shigella flexneri 2a str. 2457T 1080181 NP_839148.1 CDS yicO NC_004741.1 3864319 3865731 R residues 1 to 450 of 470 are 96.44 pct identical to residues 1 to 450 of 470 from Escherichia coli K-12 : B3664; hypothetical protein complement(3864319..3865731) Shigella flexneri 2a str. 2457T 1080183 NP_839149.1 CDS yicP NC_004741.1 3865828 3867594 D catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 3865828..3867594 Shigella flexneri 2a str. 2457T 1080184 NP_839150.1 CDS uhpT NC_004741.1 3867640 3869031 R cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter complement(3867640..3869031) Shigella flexneri 2a str. 2457T 1080185 NP_839151.1 CDS uhpC NC_004741.1 3869169 3870488 R membrane protein regulates uhpT expression; regulatory protein UhpC complement(3869169..3870488) Shigella flexneri 2a str. 2457T 1080186 NP_839152.1 CDS uhpB NC_004741.1 3870498 3872000 R Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB complement(3870498..3872000) Shigella flexneri 2a str. 2457T 1080187 NP_839153.1 CDS uhpA NC_004741.1 3872000 3872590 R response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA complement(3872000..3872590) Shigella flexneri 2a str. 2457T 1080188 NP_839154.1 CDS ilvN NC_004741.1 3872665 3872955 R with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit complement(3872665..3872955) Shigella flexneri 2a str. 2457T 1080190 NP_839155.1 CDS ilvB NC_004741.1 3872959 3874647 R catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase catalytic subunit complement(3872959..3874647) Shigella flexneri 2a str. 2457T 1080191 NP_839156.1 CDS ivbL NC_004741.1 3874753 3874851 R residues 1 to 32 of 32 are 65.62 pct identical to residues 1 to 32 of 32 from Escherichia coli K-12 : B3672; ilvB operon leader peptide complement(3874753..3874851) Shigella flexneri 2a str. 2457T 1080192 NP_839157.1 CDS emrD NC_004741.1 3875818 3876969 D multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 3875818..3876969 Shigella flexneri 2a str. 2457T 1080193 NP_839158.1 CDS yidF NC_004741.1 3876977 3877474 R residues 1 to 165 of 165 are 99.39 pct identical to residues 1 to 165 of 165 from Escherichia coli K-12 : B3674; transcriptional regulator complement(3876977..3877474) Shigella flexneri 2a str. 2457T 1080194 NP_839159.1 CDS yidG NC_004741.1 3877471 3877833 R residues 1 to 120 of 120 are 86.66 pct identical to residues 1 to 120 of 120 from Escherichia coli K-12 : B3675; hypothetical protein complement(3877471..3877833) Shigella flexneri 2a str. 2457T 1080195 NP_839160.1 CDS yidH NC_004741.1 3877823 3878170 R residues 1 to 91 of 115 are 84.61 pct identical to residues 1 to 91 of 115 from Escherichia coli K-12 : B3676; hypothetical protein complement(3877823..3878170) Shigella flexneri 2a str. 2457T 1080196 NP_839161.1 CDS yidI NC_004741.1 3878279 3878692 D residues 1 to 137 of 137 are 70.46 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B3677; hypothetical protein 3878279..3878692 Shigella flexneri 2a str. 2457T 1080197 NP_839162.1 CDS yidK NC_004741.1 3880216 3881931 R uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; symporter YidK complement(3880216..3881931) Shigella flexneri 2a str. 2457T 1080199 NP_839163.1 CDS yidL NC_004741.1 3882098 3882991 D residues 1 to 297 of 297 are 90.23 pct identical to residues 11 to 307 of 307 from Escherichia coli K-12 : B3680; ARAC-type regulatory protein 3882098..3882991 Shigella flexneri 2a str. 2457T 1080200 NP_839164.1 CDS glvB NC_004741.1 3883802 3884287 R residues 1 to 161 of 161 are 100.00 pct identical to residues 1 to 161 of 161 from Escherichia coli K-12 : B3682; arbutin specific enzyme IIB component of PTS complement(3883802..3884287) Shigella flexneri 2a str. 2457T 1080202 NP_839165.1 CDS yidP NC_004741.1 3885713 3886387 D residues 1 to 224 of 224 are 99.55 pct identical to residues 1 to 224 of 238 from Escherichia coli K-12 : B3684; transcriptional regulator 3885713..3886387 Shigella flexneri 2a str. 2457T 1080204 NP_839166.1 CDS yidE NC_004741.1 3886426 3888087 R residues 1 to 553 of 553 are 88.24 pct identical to residues 9 to 561 of 561 from Escherichia coli K-12 : B3685; hypothetical protein complement(3886426..3888087) Shigella flexneri 2a str. 2457T 1080205 NP_839167.1 CDS ibpB NC_004741.1 3888283 3888711 R 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB complement(3888283..3888711) Shigella flexneri 2a str. 2457T 1080206 NP_839168.1 CDS ibpA NC_004741.1 3888823 3889236 R with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA complement(3888823..3889236) Shigella flexneri 2a str. 2457T 1076450 NP_839169.2 CDS yidQ NC_004741.1 3889541 3889873 D residues 1 to 135 of 135 are 100.00 pct identical to residues 1 to 135 of 135 from Escherichia coli K-12 : B3688; hypothetical protein 3889541..3889873 Shigella flexneri 2a str. 2457T 1080207 NP_839170.1 CDS yidR NC_004741.1 3889875 3891149 R residues 1 to 424 of 424 are 94.10 pct identical to residues 1 to 416 of 416 from Escherichia coli K-12 : B3689; hypothetical protein complement(3889875..3891149) Shigella flexneri 2a str. 2457T 1080208 NP_839171.1 CDS yidS NC_004741.1 3891214 3892314 D FAD/NAD(P)-binding domain; oxidoreductase 3891214..3892314 Shigella flexneri 2a str. 2457T 1078769 NP_839172.1 CDS dgoT NC_004741.1 3892275 3893612 R residues 1 to 445 of 445 are 97.07 pct identical to residues 1 to 445 of 445 from Escherichia coli K-12 : B3691; D-galactonate transport protein complement(3892275..3893612) Shigella flexneri 2a str. 2457T 1076998 NP_839173.1 CDS dgoK NC_004741.1 3895433 3896311 R residues 1 to 292 of 292 are 97.94 pct identical to residues 1 to 292 of 292 from Escherichia coli K-12 : B3693; 2-oxo-3-deoxygalactonate kinase complement(3895433..3896311) Shigella flexneri 2a str. 2457T 1080210 NP_839174.1 CDS yidW NC_004741.1 3896308 3896997 R residues 17 to 229 of 229 are 25.76 pct identical to residues 22 to 235 of 257 from Escherichia coli K-12 : B4324; regulator protein for dgo operon complement(3896308..3896997) Shigella flexneri 2a str. 2457T 1080211 NP_839176.1 CDS yidA NC_004741.1 3897977 3898789 R YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase complement(3897977..3898789) Shigella flexneri 2a str. 2457T 1080213 NP_839177.1 CDS yidB NC_004741.1 3898903 3899301 R residues 1 to 132 of 132 are 98.48 pct identical to residues 4 to 135 of 135 from Escherichia coli K-12 : B3698; hypothetical protein complement(3898903..3899301) Shigella flexneri 2a str. 2457T 1080214 NP_839178.1 CDS gyrB NC_004741.1 3899541 3901955 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(3899541..3901955) Shigella flexneri 2a str. 2457T 1080215 NP_839179.1 CDS recF NC_004741.1 3901984 3903057 R Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F complement(3901984..3903057) Shigella flexneri 2a str. 2457T 1080216 NP_839180.1 CDS dnaN NC_004741.1 3903057 3904157 R binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta complement(3903057..3904157) Shigella flexneri 2a str. 2457T 1080217 NP_839181.1 CDS dnaA NC_004741.1 3904162 3905565 R binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein complement(3904162..3905565) Shigella flexneri 2a str. 2457T 1080218 NP_839182.1 CDS rpmH NC_004741.1 3906172 3906312 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 3906172..3906312 Shigella flexneri 2a str. 2457T 1080219 NP_839183.1 CDS rnpA NC_004741.1 3906329 3906688 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 3906329..3906688 Shigella flexneri 2a str. 2457T 1080220 NP_839184.1 CDS yidC NC_004741.1 3906912 3908558 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 3906912..3908558 Shigella flexneri 2a str. 2457T 1080221 NP_839185.1 CDS trmE NC_004741.1 3908664 3910028 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 3908664..3910028 Shigella flexneri 2a str. 2457T 1080222 NP_839186.1 CDS S4014 NC_004741.1 3910242 3910745 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(3910242..3910745) Shigella flexneri 2a str. 2457T 1080223 NP_839187.1 CDS S4015 NC_004741.1 3910664 3910939 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3910664..3910939) Shigella flexneri 2a str. 2457T 1080224 NP_839188.1 CDS tnaL NC_004741.1 3911046 3911120 D residues 1 to 24 of 24 are 95.83 pct identical to residues 1 to 24 of 24 from Escherichia coli K-12 : B3707; tryptophanase leader peptide 3911046..3911120 Shigella flexneri 2a str. 2457T 1080225 NP_839189.1 CDS tnaA NC_004741.1 3911341 3912756 D tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 3911341..3912756 Shigella flexneri 2a str. 2457T 1080226 NP_839190.1 CDS tnaB NC_004741.1 3912847 3914094 D tryptophan transporter of low affinity; tryptophan permease TnaB 3912847..3914094 Shigella flexneri 2a str. 2457T 1080227 NP_839191.1 CDS yidY NC_004741.1 3914226 3915401 D Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 3914226..3915401 Shigella flexneri 2a str. 2457T 1080228 NP_839192.1 CDS S4021 NC_004741.1 3916068 3916781 R residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB complement(3916068..3916781) Shigella flexneri 2a str. 2457T 1080230 NP_839193.1 CDS S4022 NC_004741.1 3916922 3917224 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA complement(3916922..3917224) Shigella flexneri 2a str. 2457T 1080231 NP_839194.1 CDS yieE NC_004741.1 3917759 3918508 D residues 1 to 249 of 249 are 98.79 pct identical to residues 5 to 253 of 253 from Escherichia coli K-12 : B3712; hypothetical protein 3917759..3918508 Shigella flexneri 2a str. 2457T 1080232 NP_839195.1 CDS yieF NC_004741.1 3918530 3919096 D residues 1 to 188 of 188 are 100.00 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 : B3713; hypothetical protein 3918530..3919096 Shigella flexneri 2a str. 2457T 1080233 NP_839196.1 CDS yieG NC_004741.1 3919150 3920487 R residues 1 to 445 of 445 are 90.11 pct identical to residues 1 to 445 of 445 from Escherichia coli K-12 : B3714; membrane / transport protein complement(3919150..3920487) Shigella flexneri 2a str. 2457T 1080234 NP_839197.1 CDS yieH NC_004741.1 3920652 3921308 D YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 3920652..3921308 Shigella flexneri 2a str. 2457T 1080235 NP_839198.1 CDS yieI NC_004741.1 3921375 3921848 D might be involved in hypersensitivity to nitrofurzone; inner membrane protein 3921375..3921848 Shigella flexneri 2a str. 2457T 1080236 NP_839199.1 CDS S4029 NC_004741.1 3922016 3922690 D residues 1 to 224 of 224 are 99.55 pct identical to residues 1 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 3922016..3922690 Shigella flexneri 2a str. 2457T 1080237 NP_839200.1 CDS S4030 NC_004741.1 3922687 3923037 D residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAK18528.1|AF348706_217 (AF348706) IS orf [Shigella flexneri]; partial; ISSfl3 orfB 3922687..3923037 Shigella flexneri 2a str. 2457T 1080238 NP_839201.1 CDS S4031 NC_004741.1 3923034 3924635 D residues 1 to 533 of 533 are 96.99 pct identical to residues 1 to 533 of 533 from GenPept : >gb|AAL72376.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfC 3923034..3924635 Shigella flexneri 2a str. 2457T 1080239 NP_839202.1 CDS yieK NC_004741.1 3925288 3926010 R residues 24 to 232 of 240 are 93.30 pct identical to residues 1 to 209 of 213 from Escherichia coli K-12 : B3718; 6-phosphogluconolactonase complement(3925288..3926010) Shigella flexneri 2a str. 2457T 1080241 NP_839203.1 CDS yieL NC_004741.1 3926012 3927187 R residues 1 to 386 of 391 are 93.00 pct identical to residues 12 to 397 of 400 from Escherichia coli K-12 : B3719; xylanase complement(3926012..3927187) Shigella flexneri 2a str. 2457T 1080242 NP_839204.1 CDS yieC NC_004741.1 3927214 3928791 R residues 1 to 525 of 525 are 96.57 pct identical to residues 14 to 538 of 538 from Escherichia coli K-12 : B3720; receptor protein complement(3927214..3928791) Shigella flexneri 2a str. 2457T 1080243 NP_839205.1 CDS S4036 NC_004741.1 3929306 3929809 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(3929306..3929809) Shigella flexneri 2a str. 2457T 1080244 NP_839206.1 CDS S4037 NC_004741.1 3929728 3930003 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(3929728..3930003) Shigella flexneri 2a str. 2457T 1080245 NP_839207.1 CDS bglB NC_004741.1 3930037 3931086 R residues 1 to 348 of 349 are 97.41 pct identical to residues 1 to 348 of 470 from Escherichia coli K-12 : B3721; phospho-beta-glucosidase B cryptic complement(3930037..3931086) Shigella flexneri 2a str. 2457T 1080246 NP_839208.1 CDS bglF NC_004741.1 3931105 3932982 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; beta-glucoside-specific PTS system components IIABC complement(3931105..3932982) Shigella flexneri 2a str. 2457T 1080247 NP_839209.1 CDS bglG NC_004741.1 3933116 3933937 R positive regulator of the beta-glucoside operon; transcriptional antiterminator; transcriptional antiterminator BglG complement(3933116..3933937) Shigella flexneri 2a str. 2457T 1080248 NP_839210.1 CDS phoU NC_004741.1 3934224 3934949 R regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU complement(3934224..3934949) Shigella flexneri 2a str. 2457T 1080249 NP_839211.1 CDS pstB NC_004741.1 3934964 3935737 R residues 1 to 257 of 257 are 95.33 pct identical to residues 1 to 257 of 257 from Escherichia coli K-12 : B3725; phosphate transporter subunit complement(3934964..3935737) Shigella flexneri 2a str. 2457T 1080250 NP_839212.1 CDS pstA NC_004741.1 3935829 3936719 R Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA complement(3935829..3936719) Shigella flexneri 2a str. 2457T 1080251 NP_839213.1 CDS pstC NC_004741.1 3936767 3937678 R part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC complement(3936767..3937678) Shigella flexneri 2a str. 2457T 1080252 NP_839214.1 CDS pstS NC_004741.1 3937765 3938805 R residues 1 to 346 of 346 are 97.10 pct identical to residues 1 to 346 of 346 from Escherichia coli K-12 : B3728; phosphate ABC transporter substrate-binding protein complement(3937765..3938805) Shigella flexneri 2a str. 2457T 1080253 NP_839215.1 CDS S4046 NC_004741.1 3940059 3940334 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3940059..3940334 Shigella flexneri 2a str. 2457T 1080254 NP_839216.1 CDS lpfC NC_004741.1 3940913 3943435 R residues 1 to 840 of 840 are 99.40 pct identical to residues 1 to 840 of 840 from GenPept : >gb|AAL18163.1| (AY057066) LpfC [Escherichia coli]; long polar fimbriae complement(3940913..3943435) Shigella flexneri 2a str. 2457T 1080255 NP_839217.2 CDS S4049 NC_004741.1 3943581 3943946 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3943581..3943946 Shigella flexneri 2a str. 2457T 1080256 NP_839218.2 CDS S4050 NC_004741.1 3943904 3944809 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3943904..3944809 Shigella flexneri 2a str. 2457T 1080257 NP_839219.1 CDS iutA NC_004741.1 3946459 3948654 R residues 1 to 731 of 731 are 97.40 pct identical to residues 2 to 732 of 732 from GenPept : >gb|AAD44750.1|AF141323_21 (AF141323) IutA [Shigella flexneri]; ferric siderophore receptor complement(3946459..3948654) Shigella flexneri 2a str. 2457T 1080258 NP_839220.1 CDS iucD NC_004741.1 3948660 3949997 R residues 1 to 445 of 445 are 100.00 pct identical to residues 1 to 445 of 445 from GenPept : >gb|AAD44749.1|AF141323_20 (AF141323) IucD [Shigella flexneri]; lysine:N6-hydroxylase complement(3948660..3949997) Shigella flexneri 2a str. 2457T 1080259 NP_839221.1 CDS iucC NC_004741.1 3949994 3951736 R residues 1 to 580 of 580 are 99.48 pct identical to residues 1 to 580 of 580 from GenPept : >gb|AAK71633.1|AF335540_5 (AF335540) IucC [Shigella boydii]; siderophore biosynthesis protein complement(3949994..3951736) Shigella flexneri 2a str. 2457T 1080260 NP_839222.1 CDS iucB NC_004741.1 3951736 3952683 R residues 1 to 315 of 315 are 100.00 pct identical to residues 1 to 315 of 315 from GenPept : >gb|AAK71632.1|AF335540_4 (AF335540) IucB [Shigella boydii]; siderophore biosynthesis protein complement(3951736..3952683) Shigella flexneri 2a str. 2457T 1080261 NP_839223.1 CDS iucA NC_004741.1 3952684 3954465 R residues 1 to 593 of 593 are 100.00 pct identical to residues 1 to 593 of 593 from GenPept : >gb|AAD44746.1|AF141323_17 (AF141323) IucA [Shigella flexneri]; siderophore biosynthesis protein complement(3952684..3954465) Shigella flexneri 2a str. 2457T 1080262 NP_839224.1 CDS imm NC_004741.1 3954544 3955737 D residues 1 to 397 of 397 are 93.19 pct identical to residues 1 to 397 of 397 from GenPept : >gb|AAD44744.1|AF141323_15 (AF141323) ShiF [Shigella flexneri]; membrane transport protein 3954544..3955737 Shigella flexneri 2a str. 2457T 1080263 NP_839225.1 CDS shiE NC_004741.1 3955687 3956658 R residues 1 to 323 of 323 are 99.68 pct identical to residues 1 to 323 of 323 from NRprotein_Feb03 : >ref|NP_709452.1| orf, partial conserved hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN45159.1|AE015379_1 orf, partial conserved hypothetical protein [Shigella flexneri 2a str. 301]; hypothetical protein complement(3955687..3956658) Shigella flexneri 2a str. 2457T 1080264 NP_839226.1 CDS S4058 NC_004741.1 3956539 3956814 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3956539..3956814 Shigella flexneri 2a str. 2457T 1080265 NP_839227.1 CDS S4059 NC_004741.1 3956733 3957236 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 3956733..3957236 Shigella flexneri 2a str. 2457T 1080266 NP_839228.1 CDS shiD NC_004741.1 3957757 3958155 R residues 1 to 132 of 132 are 100.00 pct identical to residues 1 to 132 of 132 from NRprotein_Feb03 : >ref|NP_709450.1| colicin V immunity protein shiD [imported] [Shigella flexneri 2a str. 301] pir||T44474 colicin V immunity protein shiD [imported] - Shigella flexneri gb|AAD44741.1|AF141323_12 ShiD [Shigella flexneri] gb|AAD54668.1|AF097520_7 novel colicin immunity protein [Shigella flexneri] gb|AA; colV-immunity protein complement(3957757..3958155) Shigella flexneri 2a str. 2457T 1080267 NP_839229.2 CDS S4060 NC_004741.1 3959474 3959839 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3959474..3959839 Shigella flexneri 2a str. 2457T 1080268 NP_839230.2 CDS S4061 NC_004741.1 3959797 3960702 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3959797..3960702 Shigella flexneri 2a str. 2457T 1080269 NP_839231.1 CDS S4062 NC_004741.1 3961705 3962031 D residues 1 to 108 of 108 are 74.07 pct identical to residues 1 to 108 of 108 from GenPept : >emb|CAA35935.1| (X51586) unknown peptide (AA 1-108) [Shigella sonnei]; IS629 orfA 3961705..3962031 Shigella flexneri 2a str. 2457T 1080270 NP_839232.1 CDS S4063 NC_004741.1 3962267 3962914 D residues 1 to 215 of 215 are 99.53 pct identical to residues 8 to 222 of 222 from GenPept : >gb|AAL72361.1| (AF386526) transposase [Shigella flexneri 2a]; IS629 orfB 3962267..3962914 Shigella flexneri 2a str. 2457T 1080271 NP_839233.1 CDS shiC NC_004741.1 3962995 3963513 R residues 1 to 172 of 172 are 100.00 pct identical to residues 1 to 172 of 172 from NRprotein_Feb03 : >pir||T44468 hypothetical protein shiC [imported] - Shigella flexneri gb|AAD44735.1|AF141323_6 ShiC [Shigella flexneri] gb|AAD54667.1|AF097520_5 unknown [Shigella flexneri]; hypothetical protein complement(3962995..3963513) Shigella flexneri 2a str. 2457T 1080272 NP_839234.1 CDS S4064 NC_004741.1 3963698 3963997 D residues 1 to 99 of 99 are 74.74 pct identical to residues 4 to 102 of 102 from GenPept : >gb|AAK18485.1|AF348706_174 (AF348706) orf, hypothetical [Shigella flexneri]; IS3 orfA 3963698..3963997 Shigella flexneri 2a str. 2457T 1080273 NP_839235.1 CDS S4832 NC_004741.1 3963994 3964386 D residues 1 to 130 of 130 are 100.00 pct identical to residues 1 to 130 of 130 from NRprotein_Feb03 : >ref|NP_709441.1| transposase tnpB [imported] [Shigella flexneri 2a str. 301] pir||T44467 transposase tnpB [imported] - Shigella flexneri gb|AAD44734.1|AF141323_5 TnpB [Shigella flexneri] gb|AAN45148.1|AE015378_3 transposase tnpB [imported] [Shigella flexneri 2a str. 301]; IS3 orfB 3963994..3964386 Shigella flexneri 2a str. 2457T 1080274 NP_839236.1 CDS shiB NC_004741.1 3964845 3965306 R residues 1 to 153 of 153 are 99.34 pct identical to residues 1 to 153 of 153 from NRprotein_Feb03 : >pir||T44465 hypothetical protein shiB [imported] - Shigella flexneri gb|AAD44732.1|AF141323_3 ShiB [Shigella flexneri]; hypothetical protein complement(3964845..3965306) Shigella flexneri 2a str. 2457T 1080275 NP_839237.1 CDS shiA NC_004741.1 3965821 3966864 R residues 1 to 347 of 347 are 100.00 pct identical to residues 1 to 347 of 347 from NRprotein_Feb03 : >ref|NP_709438.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301] pir||T44464 hypothetical protein shiA [imported] - Shigella flexneri gb|AAD44731.1|AF141323_2 ShiA [Shigella flexneri] gb|AAN45145.1|AE015377_5 orf, conserved hypothetical protein [Shigella flexneri 2a str. 301]; hypothetical protein complement(3965821..3966864) Shigella flexneri 2a str. 2457T 1080276 NP_839238.1 CDS S4835 NC_004741.1 3967276 3968487 R residues 1 to 403 of 403 are 100.00 pct identical to residues 1 to 403 of 403 from NRprotein_Feb03 : >ref|NP_709437.1| Sai integrase [Shigella flexneri 2a str. 301] gb|AAD54663.1|AF097520_1 Sai integrase [Shigella flexneri] gb|AAN45144.1|AE015377_4 Sai integrase [Shigella flexneri 2a str. 301]; integrase complement(3967276..3968487) Shigella flexneri 2a str. 2457T 1080277 NP_839239.1 CDS yicI NC_004741.1 3970539 3972857 D catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase 3970539..3972857 Shigella flexneri 2a str. 2457T 1080280 NP_839240.1 CDS yicH NC_004741.1 3972910 3974619 R residues 24 to 569 of 569 are 99.08 pct identical to residues 24 to 569 of 569 from Escherichia coli K-12 : B3655; hypothetical protein complement(3972910..3974619) Shigella flexneri 2a str. 2457T 1080281 NP_839241.1 CDS yicE NC_004741.1 3974740 3976131 R residues 1 to 463 of 463 are 96.97 pct identical to residues 1 to 463 of 463 from Escherichia coli K-12 : B3654; transporter complement(3974740..3976131) Shigella flexneri 2a str. 2457T 1080282 NP_839242.1 CDS gltS NC_004741.1 3976411 3977616 D residues 1 to 401 of 401 are 82.54 pct identical to residues 1 to 401 of 401 from Escherichia coli K-12 : B3653; glutamate transport protein 3976411..3977616 Shigella flexneri 2a str. 2457T 1080283 NP_839243.1 CDS recG NC_004741.1 3977650 3979731 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(3977650..3979731) Shigella flexneri 2a str. 2457T 1080284 NP_839244.1 CDS spoU NC_004741.1 3979737 3980426 R specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase complement(3979737..3980426) Shigella flexneri 2a str. 2457T 1080285 NP_839245.1 CDS spoT NC_004741.1 3980433 3982541 R residues 1 to 702 of 702 are 98.14 pct identical to residues 1 to 702 of 702 from Escherichia coli K-12 : B3650; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase complement(3980433..3982541) Shigella flexneri 2a str. 2457T 1080286 NP_839246.1 CDS rpoZ NC_004741.1 3982560 3982835 R promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(3982560..3982835) Shigella flexneri 2a str. 2457T 1080287 NP_839247.1 CDS gmk NC_004741.1 3982890 3983513 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(3982890..3983513) Shigella flexneri 2a str. 2457T 1080288 NP_839248.1 CDS ligB NC_004741.1 3983771 3985453 D this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 3983771..3985453 Shigella flexneri 2a str. 2457T 1080289 NP_839249.1 CDS yicG NC_004741.1 3985450 3986121 R residues 1 to 223 of 223 are 73.54 pct identical to residues 1 to 223 of 223 from Escherichia coli K-12 : B3646; hypothetical protein complement(3985450..3986121) Shigella flexneri 2a str. 2457T 1080290 NP_839250.1 CDS dinD NC_004741.1 3986358 3987182 R residues 1 to 274 of 274 are 97.81 pct identical to residues 5 to 278 of 278 from Escherichia coli K-12 : B3645; DNA-damage-inducible protein D complement(3986358..3987182) Shigella flexneri 2a str. 2457T 1080291 NP_839251.1 CDS yicC NC_004741.1 3987403 3988266 R residues 1 to 287 of 287 are 94.42 pct identical to residues 1 to 287 of 287 from Escherichia coli K-12 : B3644; hypothetical protein complement(3987403..3988266) Shigella flexneri 2a str. 2457T 1080292 NP_839252.1 CDS rph NC_004741.1 3988393 3989109 D RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 3988393..3989109 Shigella flexneri 2a str. 2457T 1080293 NP_839253.1 CDS pyrE NC_004741.1 3989175 3989816 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 3989175..3989816 Shigella flexneri 2a str. 2457T 1080294 NP_839254.2 CDS slmA NC_004741.1 3989853 3990449 R FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein complement(3989853..3990449) Shigella flexneri 2a str. 2457T 1080295 NP_839255.1 CDS dut NC_004741.1 3990556 3991014 R catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase complement(3990556..3991014) Shigella flexneri 2a str. 2457T 1080296 NP_839256.2 CDS dfp NC_004741.1 3990992 3992212 R catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase complement(3990992..3992212) Shigella flexneri 2a str. 2457T 1080297 NP_839257.2 CDS radC NC_004741.1 3992378 3993052 D Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 3992378..3993052 Shigella flexneri 2a str. 2457T 1080298 NP_839258.1 CDS rpmB NC_004741.1 3993269 3993505 D required for 70S ribosome assembly; 50S ribosomal protein L28 3993269..3993505 Shigella flexneri 2a str. 2457T 1080299 NP_839259.1 CDS rpmG NC_004741.1 3993526 3993693 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 3993526..3993693 Shigella flexneri 2a str. 2457T 1080300 NP_839260.1 CDS mutM NC_004741.1 3993791 3994600 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 3993791..3994600 Shigella flexneri 2a str. 2457T 1080301 NP_839261.1 CDS coaD NC_004741.1 3994639 3995118 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(3994639..3995118) Shigella flexneri 2a str. 2457T 1080302 NP_839262.1 CDS kdtA NC_004741.1 3995126 3996403 R catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase complement(3995126..3996403) Shigella flexneri 2a str. 2457T 1080303 NP_839263.1 CDS S4097 NC_004741.1 3996537 3996812 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3996537..3996812 Shigella flexneri 2a str. 2457T 1080304 NP_839264.1 CDS S4098 NC_004741.1 3996731 3997234 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 3996731..3997234 Shigella flexneri 2a str. 2457T 1080305 NP_839265.1 CDS waaQ NC_004741.1 3997592 3998650 D residues 1 to 352 of 352 are 96.59 pct identical to residues 1 to 352 of 352 from GenPept : >gb|AAG58776.1|AE005590_11 (AE005590) LPS biosynthesis enzyme [Escherichia coli O157:H7 EDL933]; lipopolysaccharide core biosynthesis protein 3997592..3998650 Shigella flexneri 2a str. 2457T 1080306 NP_839266.1 CDS waaG NC_004741.1 3998647 3999771 D residues 1 to 374 of 374 are 99.46 pct identical to residues 1 to 374 of 374 from GenPept : >gb|AAC69678.1| (AF019746) UDP-glucose:(heptosyl) LPS alpha1,3-glucosyltransferase WaaG [Escherichia coli]; LPS alpha1,3-glucosyltransferase 3998647..3999771 Shigella flexneri 2a str. 2457T 1080307 NP_839267.1 CDS waaP NC_004741.1 3999755 4000561 D residues 1 to 268 of 268 are 93.65 pct identical to residues 1 to 268 of 268 from GenPept : >gb|AAG58774.1|AE005590_9 (AE005590) LPS biosynthesis enzyme [Escherichia coli O157:H7 EDL933]; lipopolysaccharide core biosynthesis protein 3999755..4000561 Shigella flexneri 2a str. 2457T 1080308 NP_839268.1 CDS waaL NC_004741.1 4000604 4001611 D residues 1 to 335 of 335 are 99.70 pct identical to residues 1 to 335 of 335 from GenPept : >gb|AAG58773.1|AE005590_8 (AE005590) LPS biosynthesis enzyme [Escherichia coli O157:H7 EDL933]; UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase 4000604..4001611 Shigella flexneri 2a str. 2457T 1080309 NP_839269.1 CDS waaY NC_004741.1 4001637 4002344 D residues 1 to 235 of 235 are 93.19 pct identical to residues 1 to 235 of 235 from GenPept : >gb|AAC69664.1| (AF019745) WaaY [Escherichia coli]; lipopolysaccharide core biosynthesis protein 4001637..4002344 Shigella flexneri 2a str. 2457T 1080310 NP_839270.1 CDS waaJ NC_004741.1 4002369 4003382 D residues 1 to 337 of 337 are 94.06 pct identical to residues 1 to 337 of 337 from GenPept : >gb|AAG58771.1|AE005590_6 (AE005590) LPS biosynthesis enzyme [Escherichia coli O157:H7 EDL933]; UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase 4002369..4003382 Shigella flexneri 2a str. 2457T 1080311 NP_839271.1 CDS waaD NC_004741.1 4003391 4004533 D residues 1 to 380 of 380 are 96.31 pct identical to residues 1 to 380 of 380 from GenPept : >gb|AAG58770.1|AE005590_5 (AE005590) LPS biosynthesis enzyme [Escherichia coli O157:H7 EDL933]; lipopolysaccharide 1,2-N- acetylglucosaminetransferase 4003391..4004533 Shigella flexneri 2a str. 2457T 1080312 NP_839272.1 CDS waaI NC_004741.1 4004569 4005777 R residues 1 to 402 of 402 are 93.28 pct identical to residues 1 to 402 of 402 from GenPept : >gb|AAG58769.1|AE005590_4 (AE005590) LPS biosynthesis enzyme [Escherichia coli O157:H7 EDL933]; lipid A-core, surface polymer ligase complement(4004569..4005777) Shigella flexneri 2a str. 2457T 1080189 NP_839273.1 CDS rfaC NC_004741.1 4005774 4006736 R residues 1 to 307 of 320 are 94.13 pct identical to residues 11 to 317 of 319 from Escherichia coli K-12 : B3621; involved in lipopolysaccharide core biosynthesis; ADP-heptose--LPS heptosyltransferase complement(4005774..4006736) Shigella flexneri 2a str. 2457T 1080313 NP_839274.1 CDS rfaF NC_004741.1 4006770 4007816 R catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose--LPS heptosyltransferase complement(4006770..4007816) Shigella flexneri 2a str. 2457T 1080314 NP_839275.1 CDS rfaD NC_004741.1 4007826 4008758 R catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase complement(4007826..4008758) Shigella flexneri 2a str. 2457T 1080315 NP_839276.1 CDS kbl NC_004741.1 4010194 4011390 D catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 4010194..4011390 Shigella flexneri 2a str. 2457T 1080316 NP_839277.1 CDS tdh NC_004741.1 4011400 4012425 D converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 4011400..4012425 Shigella flexneri 2a str. 2457T 1080317 NP_839278.1 CDS S4112 NC_004741.1 4012655 4012930 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4012655..4012930 Shigella flexneri 2a str. 2457T 1080939 NP_839279.1 CDS S4113 NC_004741.1 4012849 4013352 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4012849..4013352 Shigella flexneri 2a str. 2457T 1079655 NP_839280.1 CDS yibD NC_004741.1 4013434 4013574 D residues 1 to 46 of 46 are 100.00 pct identical to residues 299 to 344 of 344 from Escherichia coli K-12 : B3615; regulator 4013434..4013574 Shigella flexneri 2a str. 2457T 1080318 NP_839281.1 CDS yibQ NC_004741.1 4013561 4014394 R residues 1 to 277 of 277 are 99.63 pct identical to residues 1 to 277 of 277 from Escherichia coli K-12 : B3614; hypothetical protein complement(4013561..4014394) Shigella flexneri 2a str. 2457T 1080319 NP_839282.2 CDS yibP NC_004741.1 4014524 4015807 R residues 1 to 419 of 419 are 92.84 pct identical to residues 9 to 427 of 427 from Escherichia coli K-12 : B3613; hypothetical protein complement(4014524..4015807) Shigella flexneri 2a str. 2457T 1080320 NP_839283.1 CDS yibO NC_004741.1 4015817 4017361 R catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase complement(4015817..4017361) Shigella flexneri 2a str. 2457T 1080321 NP_839284.1 CDS yibN NC_004741.1 4017606 4018037 D residues 1 to 143 of 143 are 99.30 pct identical to residues 1 to 143 of 143 from Escherichia coli K-12 : B3611; hypothetical protein 4017606..4018037 Shigella flexneri 2a str. 2457T 1080322 NP_839285.1 CDS grxC NC_004741.1 4018179 4018430 D residues 1 to 83 of 83 are 98.79 pct identical to residues 1 to 83 of 83 from Escherichia coli K-12 : B3610; glutaredoxin 3 4018179..4018430 Shigella flexneri 2a str. 2457T 1080323 NP_839286.1 CDS secB NC_004741.1 4018493 4018960 D molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 4018493..4018960 Shigella flexneri 2a str. 2457T 1080324 NP_839287.1 CDS gpsA NC_004741.1 4018960 4019979 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 4018960..4019979 Shigella flexneri 2a str. 2457T 1080325 NP_839288.1 CDS cysE NC_004741.1 4020059 4020880 D catalyzes the O-acetylation of serine; serine acetyltransferase 4020059..4020880 Shigella flexneri 2a str. 2457T 1080326 NP_839289.1 CDS yibK NC_004741.1 4020933 4021406 R member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK complement(4020933..4021406) Shigella flexneri 2a str. 2457T 1080327 NP_839290.1 CDS lldD NC_004741.1 4021602 4022792 R flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase complement(4021602..4022792) Shigella flexneri 2a str. 2457T 1078229 NP_839291.1 CDS lldR NC_004741.1 4022789 4023565 R represses the lctPRD operon; DNA-binding transcriptional repressor LldR complement(4022789..4023565) Shigella flexneri 2a str. 2457T 1080328 NP_839292.1 CDS lldP NC_004741.1 4023565 4025220 R residues 1 to 551 of 551 are 84.93 pct identical to residues 1 to 551 of 551 from Escherichia coli K-12 : B3603; L-lactate permease complement(4023565..4025220) Shigella flexneri 2a str. 2457T 1080329 NP_839293.1 CDS S4130 NC_004741.1 4031481 4031756 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4031481..4031756 Shigella flexneri 2a str. 2457T 1080331 NP_839294.1 CDS S4131 NC_004741.1 4031675 4032178 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4031675..4032178 Shigella flexneri 2a str. 2457T 1080332 NP_839295.1 CDS yibL NC_004741.1 4032297 4032659 R residues 1 to 120 of 120 are 85.83 pct identical to residues 1 to 120 of 120 from Escherichia coli K-12 : B3602; hypothetical protein complement(4032297..4032659) Shigella flexneri 2a str. 2457T 1080333 NP_839296.1 CDS mtlR NC_004741.1 4033164 4033751 R Acts as a repressor of the mtlAD operon; mannitol repressor protein complement(4033164..4033751) Shigella flexneri 2a str. 2457T 1080334 NP_839297.1 CDS mtlD NC_004741.1 4033751 4034899 R residues 1 to 382 of 382 are 98.95 pct identical to residues 1 to 382 of 382 from Escherichia coli K-12 : B3600; mannitol-1-phosphate 5-dehydrogenase complement(4033751..4034899) Shigella flexneri 2a str. 2457T 1080335 NP_839298.1 CDS mtlA NC_004741.1 4034994 4036907 R residues 1 to 637 of 637 are 90.42 pct identical to residues 1 to 637 of 637 from Escherichia coli K-12 : B3599; PTS system, mannitol-specific enzyme IIABC components complement(4034994..4036907) Shigella flexneri 2a str. 2457T 1080336 NP_839299.1 CDS yibI NC_004741.1 4037444 4037806 D residues 1 to 120 of 120 are 99.16 pct identical to residues 1 to 120 of 120 from Escherichia coli K-12 : B3598; hypothetical protein 4037444..4037806 Shigella flexneri 2a str. 2457T 1080337 NP_839300.1 CDS yibH NC_004741.1 4037809 4038894 D residues 24 to 361 of 361 are 100.00 pct identical to residues 41 to 378 of 378 from Escherichia coli K-12 : B3597; hypothetical protein 4037809..4038894 Shigella flexneri 2a str. 2457T 1080338 NP_839301.1 CDS yibF NC_004741.1 4038965 4039573 D residues 1 to 202 of 202 are 99.50 pct identical to residues 1 to 202 of 202 from Escherichia coli K-12 : B3592; glutathione S-transferase 4038965..4039573 Shigella flexneri 2a str. 2457T 1080339 NP_839302.1 CDS selA NC_004741.1 4039671 4041062 D catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 4039671..4041062 Shigella flexneri 2a str. 2457T 1080340 NP_839303.1 CDS selB NC_004741.1 4041059 4042903 D residues 1 to 614 of 614 are 98.37 pct identical to residues 1 to 614 of 614 from Escherichia coli K-12 : B3590; selenocysteinyl-tRNA-specific translation factor 4041059..4042903 Shigella flexneri 2a str. 2457T 1080341 NP_839304.1 CDS yiaY NC_004741.1 4043093 4044244 D residues 1 to 381 of 383 are 96.06 pct identical to residues 1 to 381 of 382 from Escherichia coli K-12 : B3589; alcohol dehydrogenase 4043093..4044244 Shigella flexneri 2a str. 2457T 1080342 NP_839305.1 CDS aldB NC_004741.1 4044319 4045947 D residues 1 to 542 of 542 are 96.30 pct identical to residues 1 to 542 of 542 from Escherichia coli K-12 : B3588; aldehyde dehydrogenase B (lactaldehyde dehydrogenase) 4044319..4045947 Shigella flexneri 2a str. 2457T 1080343 NP_839306.1 CDS S4143 NC_004741.1 4046643 4047146 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(4046643..4047146) Shigella flexneri 2a str. 2457T 1080344 NP_839307.1 CDS S4144 NC_004741.1 4047065 4047340 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(4047065..4047340) Shigella flexneri 2a str. 2457T 1080345 NP_839308.1 CDS S4145 NC_004741.1 4047374 4048666 R residues 27 to 390 of 430 are 83.51 pct identical to residues 27 to 390 of 424 from Escherichia coli K-12 : B3578; hypothetical protein complement(4047374..4048666) Shigella flexneri 2a str. 2457T 1080346 NP_839309.1 CDS S4147 NC_004741.1 4049001 4049504 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(4049001..4049504) Shigella flexneri 2a str. 2457T 1079322 NP_839310.1 CDS S4148 NC_004741.1 4049423 4049698 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAA96691.1| (M37616) insA gene product [Insertion sequence IS1]; IS1 orfA complement(4049423..4049698) Shigella flexneri 2a str. 2457T 1080347 NP_839311.1 CDS yiaK NC_004741.1 4049913 4050911 R NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase complement(4049913..4050911) Shigella flexneri 2a str. 2457T 1080353 NP_839312.1 CDS yiaJ NC_004741.1 4051111 4051959 D residues 1 to 282 of 282 are 99.64 pct identical to residues 1 to 282 of 282 from Escherichia coli K-12 : B3574; regulator 4051111..4051959 Shigella flexneri 2a str. 2457T 1080355 NP_839313.1 CDS yiaI NC_004741.1 4052061 4052534 D residues 1 to 157 of 157 are 97.45 pct identical to residues 1 to 157 of 157 from Escherichia coli K-12 : B3573; hypothetical protein 4052061..4052534 Shigella flexneri 2a str. 2457T 1080357 NP_839314.1 CDS avtA NC_004741.1 4052685 4053938 R transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase complement(4052685..4053938) Shigella flexneri 2a str. 2457T 1080358 NP_839315.1 CDS malS NC_004741.1 4054116 4056146 R periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase precursor complement(4054116..4056146) Shigella flexneri 2a str. 2457T 1080359 NP_839316.1 CDS bax NC_004741.1 4056466 4057290 D residues 1 to 274 of 274 are 99.27 pct identical to residues 1 to 274 of 274 from Escherichia coli K-12 : B3570; hypothetical protein 4056466..4057290 Shigella flexneri 2a str. 2457T 1080360 NP_839317.1 CDS xylH NC_004741.1 4058654 4059835 R residues 1 to 393 of 393 are 81.67 pct identical to residues 1 to 393 of 393 from Escherichia coli K-12 : B3568; xylose transporter membrane component complement(4058654..4059835) Shigella flexneri 2a str. 2457T 1080362 NP_839318.1 CDS xylG NC_004741.1 4059813 4061354 R with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit complement(4059813..4061354) Shigella flexneri 2a str. 2457T 1080363 NP_839319.1 CDS xylF NC_004741.1 4061432 4062424 R periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF complement(4061432..4062424) Shigella flexneri 2a str. 2457T 1080364 NP_839320.1 CDS xylB NC_004741.1 4064184 4065638 D residues 1 to 484 of 484 are 89.46 pct identical to residues 1 to 484 of 484 from Escherichia coli K-12 : B3564; xylulokinase 4064184..4065638 Shigella flexneri 2a str. 2457T 1080366 NP_839321.1 CDS yiaB NC_004741.1 4065807 4066148 D residues 1 to 112 of 113 are 98.21 pct identical to residues 5 to 116 of 117 from Escherichia coli K-12 : B3563; hypothetical protein 4065807..4066148 Shigella flexneri 2a str. 2457T 1080367 NP_839322.1 CDS yiaA NC_004741.1 4066194 4066631 D residues 1 to 145 of 145 are 100.00 pct identical to residues 2 to 146 of 146 from Escherichia coli K-12 : B3562; hypothetical protein 4066194..4066631 Shigella flexneri 2a str. 2457T 1080368 NP_839323.1 CDS yiaH NC_004741.1 4066673 4067668 R residues 1 to 331 of 331 are 92.14 pct identical to residues 1 to 331 of 331 from Escherichia coli K-12 : B3561; hypothetical protein complement(4066673..4067668) Shigella flexneri 2a str. 2457T 1080369 NP_839324.1 CDS glyQ NC_004741.1 4068237 4069148 D glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 4068237..4069148 Shigella flexneri 2a str. 2457T 1080371 NP_839325.1 CDS glyS NC_004741.1 4069158 4071227 D glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 4069158..4071227 Shigella flexneri 2a str. 2457T 1080372 NP_839326.1 CDS S4167 NC_004741.1 4071285 4071788 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(4071285..4071788) Shigella flexneri 2a str. 2457T 1080373 NP_839327.1 CDS S4168 NC_004741.1 4071707 4071982 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(4071707..4071982) Shigella flexneri 2a str. 2457T 1080374 NP_839328.1 CDS S4169 NC_004741.1 4072203 4072499 D hypothetical protein 4072203..4072499 Shigella flexneri 2a str. 2457T 1080375 NP_839329.1 CDS yhiW NC_004741.1 4076000 4076728 R residues 1 to 242 of 242 are 100.00 pct identical to residues 1 to 242 of 242 from Escherichia coli K-12 : B3515; ARAC-type regulatory protein complement(4076000..4076728) Shigella flexneri 2a str. 2457T 1080377 NP_839330.1 CDS yhiX NC_004741.1 4077096 4077920 R regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX complement(4077096..4077920) Shigella flexneri 2a str. 2457T 1080378 NP_839331.1 CDS gadA NC_004741.1 4078290 4079690 R residues 1 to 466 of 466 are 99.78 pct identical to residues 1 to 466 of 466 from Escherichia coli K-12 : B3517; glutamate decarboxylase complement(4078290..4079690) Shigella flexneri 2a str. 2457T 1080379 NP_839332.1 CDS yhjA NC_004741.1 4079901 4081298 R residues 1 to 465 of 465 are 99.56 pct identical to residues 1 to 465 of 465 from Escherichia coli K-12 : B3518; cytochrome C peroxidase complement(4079901..4081298) Shigella flexneri 2a str. 2457T 1080380 NP_839333.1 CDS S4175 NC_004741.1 4081357 4081860 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(4081357..4081860) Shigella flexneri 2a str. 2457T 1080381 NP_839334.1 CDS S4177 NC_004741.1 4081779 4082054 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(4081779..4082054) Shigella flexneri 2a str. 2457T 1080382 NP_839335.1 CDS S4178 NC_004741.1 4082600 4083451 D residues 1 to 283 of 283 are 99.64 pct identical to residues 1 to 283 of 283 from Escherichia coli K-12 : B3558; IS150 transposase 4082600..4083451 Shigella flexneri 2a str. 2457T 1080383 NP_839336.1 CDS cspA NC_004741.1 4083892 4084104 R residues 1 to 70 of 70 are 100.00 pct identical to residues 1 to 70 of 70 from Escherichia coli K-12 : B3556; major cold shock protein complement(4083892..4084104) Shigella flexneri 2a str. 2457T 1080384 NP_839337.1 CDS yiaG NC_004741.1 4084550 4084675 R residues 1 to 41 of 41 are 100.00 pct identical to residues 1 to 41 of 96 from Escherichia coli K-12 : B3555; hypothetical protein complement(4084550..4084675) Shigella flexneri 2a str. 2457T 1080385 NP_839338.1 CDS yiaF NC_004741.1 4084989 4085819 D residues 1 to 276 of 276 are 94.56 pct identical to residues 1 to 276 of 276 from Escherichia coli K-12 : B3554; hypothetical protein 4084989..4085819 Shigella flexneri 2a str. 2457T 1080386 NP_839339.1 CDS yiaE NC_004741.1 4085869 4086843 R Involved in the metabolism of aromatic amino acids; 2-hydroxyacid dehydrogenase complement(4085869..4086843) Shigella flexneri 2a str. 2457T 1080387 NP_839340.2 CDS yiaD NC_004741.1 4086947 4087597 R residues 1 to 208 of 208 are 88.94 pct identical to residues 12 to 219 of 219 from Escherichia coli K-12 : B3552; outer membrane lipoprotein complement(4086947..4087597) Shigella flexneri 2a str. 2457T 1080388 NP_839341.1 CDS bisC NC_004741.1 4087814 4090093 D residues 21 to 759 of 759 are 98.78 pct identical to residues 1 to 739 of 739 from Escherichia coli K-12 : B3551; biotin sulfoxide reductase 4087814..4090093 Shigella flexneri 2a str. 2457T 1080389 NP_839342.1 CDS yiaC NC_004741.1 4090062 4090502 R residues 1 to 146 of 146 are 97.94 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 : B3550; hypothetical protein complement(4090062..4090502) Shigella flexneri 2a str. 2457T 1080390 NP_839343.1 CDS tag NC_004741.1 4090499 4091062 R constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyladenine DNA glycosylase complement(4090499..4091062) Shigella flexneri 2a str. 2457T 1080392 NP_839344.1 CDS yhjY NC_004741.1 4091220 4091918 D residues 1 to 232 of 232 are 99.13 pct identical to residues 3 to 234 of 234 from Escherichia coli K-12 : B3548; lipase 4091220..4091918 Shigella flexneri 2a str. 2457T 1080393 NP_839345.1 CDS yhjX NC_004741.1 4092147 4093355 D residues 1 to 402 of 402 are 82.08 pct identical to residues 1 to 402 of 402 from Escherichia coli K-12 : B3547; resistance protein 4092147..4093355 Shigella flexneri 2a str. 2457T 1080394 NP_839346.2 CDS yhjW NC_004741.1 4093679 4095370 D catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 4093679..4095370 Shigella flexneri 2a str. 2457T 1080395 NP_839347.1 CDS dppA NC_004741.1 4096282 4097889 D residues 1 to 535 of 535 are 97.19 pct identical to residues 1 to 535 of 535 from Escherichia coli K-12 : B3544; dipeptide transport protein 4096282..4097889 Shigella flexneri 2a str. 2457T 1080397 NP_839348.1 CDS dppB NC_004741.1 4098197 4099216 D transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 4098197..4099216 Shigella flexneri 2a str. 2457T 1080398 NP_839349.1 CDS dppC NC_004741.1 4099226 4100128 D residues 1 to 300 of 300 are 89.99 pct identical to residues 1 to 300 of 300 from Escherichia coli K-12 : B3542; dipeptide transporter 4099226..4100128 Shigella flexneri 2a str. 2457T 1080399 NP_839350.1 CDS dppD NC_004741.1 4100139 4101122 D DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 4100139..4101122 Shigella flexneri 2a str. 2457T 1080400 NP_839351.1 CDS dppF NC_004741.1 4101119 4102123 D Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 4101119..4102123 Shigella flexneri 2a str. 2457T 1080401 NP_839352.1 CDS yhjV NC_004741.1 4102153 4103424 R residues 1 to 404 of 423 are 96.03 pct identical to residues 1 to 404 of 423 from Escherichia coli K-12 : B3539; transporter protein complement(4102153..4103424) Shigella flexneri 2a str. 2457T 1080402 NP_839353.1 CDS yhjU NC_004741.1 4104577 4106256 R residues 1 to 559 of 559 are 93.73 pct identical to residues 1 to 559 of 559 from Escherichia coli K-12 : B3538; hypothetical protein complement(4104577..4106256) Shigella flexneri 2a str. 2457T 1080403 NP_839354.1 CDS yhjT NC_004741.1 4106253 4106444 R residues 2 to 63 of 63 are 85.48 pct identical to residues 1 to 62 of 62 from Escherichia coli K-12 : B3537; hypothetical protein complement(4106253..4106444) Shigella flexneri 2a str. 2457T 1080404 NP_839355.1 CDS yhjS NC_004741.1 4106441 4108012 R residues 1 to 523 of 523 are 99.80 pct identical to residues 1 to 523 of 523 from Escherichia coli K-12 : B3536; protease complement(4106441..4108012) Shigella flexneri 2a str. 2457T 1080405 NP_839356.1 CDS yhjR NC_004741.1 4108285 4108473 D residues 1 to 62 of 62 are 100.00 pct identical to residues 1 to 62 of 62 from Escherichia coli K-12 : B3535; hypothetical protein 4108285..4108473 Shigella flexneri 2a str. 2457T 1080406 NP_839357.1 CDS yhjQ NC_004741.1 4108485 4109237 D residues 24 to 250 of 250 are 99.55 pct identical to residues 16 to 242 of 242 from Escherichia coli K-12 : B3534; cell division protein 4108485..4109237 Shigella flexneri 2a str. 2457T 1080407 NP_839358.1 CDS yhjN NC_004741.1 4111892 4114201 D binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 4111892..4114201 Shigella flexneri 2a str. 2457T 1080409 NP_839359.1 CDS yhjM NC_004741.1 4114208 4115314 D catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 4114208..4115314 Shigella flexneri 2a str. 2457T 1080412 NP_839360.2 CDS yhjK NC_004741.1 4117740 4119695 D HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli; phosphodiesterase 4117740..4119695 Shigella flexneri 2a str. 2457T 1080416 NP_839361.1 CDS dctA NC_004741.1 4119885 4121171 D involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 4119885..4121171 Shigella flexneri 2a str. 2457T 1080417 NP_839362.1 CDS yhjJ NC_004741.1 4121392 4122888 D residues 1 to 498 of 498 are 94.57 pct identical to residues 1 to 498 of 498 from Escherichia coli K-12 : B3527; hypothetical protein 4121392..4122888 Shigella flexneri 2a str. 2457T 1080418 NP_839363.1 CDS kdgK NC_004741.1 4122984 4124132 R residues 1 to 382 of 382 are 96.07 pct identical to residues 1 to 382 of 382 from Escherichia coli K-12 : B3526; ketodeoxygluconokinase complement(4122984..4124132) Shigella flexneri 2a str. 2457T 1080419 NP_839364.1 CDS yhjH NC_004741.1 4124145 4124912 D in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein 4124145..4124912 Shigella flexneri 2a str. 2457T 1080420 NP_839365.1 CDS yhjG NC_004741.1 4124982 4127042 D residues 1 to 686 of 686 are 88.48 pct identical to residues 6 to 691 of 691 from Escherichia coli K-12 : B3524; hypothetical protein 4124982..4127042 Shigella flexneri 2a str. 2457T 1080421 NP_839366.1 CDS yhjE NC_004741.1 4127224 4128546 R residues 1 to 440 of 440 are 86.59 pct identical to residues 1 to 440 of 440 from Escherichia coli K-12 : B3523; transporter complement(4127224..4128546) Shigella flexneri 2a str. 2457T 1080422 NP_839367.1 CDS yhjD NC_004741.1 4128957 4129970 R residues 1 to 337 of 337 are 99.10 pct identical to residues 1 to 337 of 337 from Escherichia coli K-12 : B3522; hypothetical protein complement(4128957..4129970) Shigella flexneri 2a str. 2457T 1080423 NP_839368.1 CDS yhjC NC_004741.1 4130019 4130990 R residues 1 to 323 of 323 are 98.14 pct identical to residues 1 to 323 of 323 from Escherichia coli K-12 : B3521; transcriptional regulator LYSR-type complement(4130019..4130990) Shigella flexneri 2a str. 2457T 1080424 NP_839369.1 CDS yhjB NC_004741.1 4131438 4132040 D residues 1 to 200 of 200 are 99.00 pct identical to residues 1 to 200 of 200 from Escherichia coli K-12 : B3520; regulator 4131438..4132040 Shigella flexneri 2a str. 2457T 1080425 NP_839370.1 CDS S4216 NC_004741.1 4132056 4133384 R residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf complement(4132056..4133384) Shigella flexneri 2a str. 2457T 1080426 NP_839371.1 CDS treF NC_004741.1 4133529 4135178 R cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase complement(4133529..4135178) Shigella flexneri 2a str. 2457T 1080413 NP_839372.1 CDS S4218 NC_004741.1 4135449 4135724 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4135449..4135724 Shigella flexneri 2a str. 2457T 1080427 NP_839373.1 CDS S4219 NC_004741.1 4135643 4136146 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4135643..4136146 Shigella flexneri 2a str. 2457T 1080428 NP_839374.1 CDS yhiE NC_004741.1 4137898 4138425 R residues 1 to 175 of 175 are 100.00 pct identical to residues 1 to 175 of 175 from Escherichia coli K-12 : B3512; hypothetical protein complement(4137898..4138425) Shigella flexneri 2a str. 2457T 1077417 NP_839375.1 CDS hdeD NC_004741.1 4139224 4139796 R residues 1 to 190 of 190 are 85.78 pct identical to residues 1 to 190 of 190 from Escherichia coli K-12 : B3511; acid-resistance membrane protein complement(4139224..4139796) Shigella flexneri 2a str. 2457T 1080430 NP_839376.1 CDS hdeA NC_004741.1 4140051 4140383 D inactive form; acid-resistance protein 4140051..4140383 Shigella flexneri 2a str. 2457T 1080431 NP_839377.1 CDS hdeB NC_004741.1 4140487 4140825 D residues 1 to 112 of 112 are 100.00 pct identical to residues 1 to 112 of 112 from Escherichia coli K-12 : B3509; acid-resistance protein 4140487..4140825 Shigella flexneri 2a str. 2457T 1080432 NP_839378.1 CDS yhiF NC_004741.1 4141577 4142107 R residues 1 to 176 of 176 are 98.86 pct identical to residues 1 to 176 of 176 from Escherichia coli K-12 : B3507; hypothetical protein complement(4141577..4142107) Shigella flexneri 2a str. 2457T 1080433 NP_839379.1 CDS slp NC_004741.1 4142263 4142862 R residues 1 to 199 of 199 are 91.95 pct identical to residues 1 to 199 of 199 from Escherichia coli K-12 : B3506; outer membrane protein induced after carbon starvation complement(4142263..4142862) Shigella flexneri 2a str. 2457T 1080434 NP_839380.1 CDS S4229 NC_004741.1 4144880 4145836 R residues 51 to 317 of 318 are 35.18 pct identical to residues 20 to 274 of 274 from GenPept : >emb|CAB73548.1| (AL139079) membrane protein [Campylobacter jejuni]; hypothetical protein complement(4144880..4145836) Shigella flexneri 2a str. 2457T 1080436 NP_839381.1 CDS S4230 NC_004741.1 4145867 4146370 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(4145867..4146370) Shigella flexneri 2a str. 2457T 1080437 NP_839382.1 CDS S4231 NC_004741.1 4146289 4146564 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(4146289..4146564) Shigella flexneri 2a str. 2457T 1080438 NP_839383.1 CDS arsR NC_004741.1 4146620 4146964 D regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 4146620..4146964 Shigella flexneri 2a str. 2457T 1080440 NP_839384.1 CDS arsB NC_004741.1 4147018 4148307 D residues 1 to 429 of 429 are 89.51 pct identical to residues 8 to 436 of 436 from Escherichia coli K-12 : B3502; arsenical pump membrane protein 4147018..4148307 Shigella flexneri 2a str. 2457T 1080441 NP_839385.1 CDS arsC NC_004741.1 4148320 4148745 D residues 1 to 141 of 141 are 100.00 pct identical to residues 1 to 141 of 141 from Escherichia coli K-12 : B3503; arsenate reductase 4148320..4148745 Shigella flexneri 2a str. 2457T 1080442 NP_839386.1 CDS S4235 NC_004741.1 4148901 4149176 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfB 4148901..4149176 Shigella flexneri 2a str. 2457T 1080443 NP_839387.1 CDS S4236 NC_004741.1 4149095 4149598 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 4149095..4149598 Shigella flexneri 2a str. 2457T 1080444 NP_839388.1 CDS gor NC_004741.1 4150511 4151863 R catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase complement(4150511..4151863) Shigella flexneri 2a str. 2457T 1080445 NP_839389.1 CDS yhiR NC_004741.1 4151935 4152777 R residues 1 to 280 of 280 are 98.57 pct identical to residues 1 to 280 of 280 from Escherichia coli K-12 : B3499; hypothetical protein complement(4151935..4152777) Shigella flexneri 2a str. 2457T 1080447 NP_839390.1 CDS prlC NC_004741.1 4152980 4155022 D residues 1 to 680 of 680 are 96.02 pct identical to residues 1 to 680 of 680 from Escherichia coli K-12 : B3498; oligopeptidase A 4152980..4155022 Shigella flexneri 2a str. 2457T 1080414 NP_839391.1 CDS yhiQ NC_004741.1 4155030 4155782 D predicted SAM-dependent methyltransferase; methyltransferase 4155030..4155782 Shigella flexneri 2a str. 2457T 1080448 NP_839392.1 CDS uspA NC_004741.1 4157618 4158052 R residues 1 to 144 of 144 are 100.00 pct identical to residues 1 to 144 of 144 from Escherichia coli K-12 : B3495; broad regulatory function; universal stress protein complement(4157618..4158052) Shigella flexneri 2a str. 2457T 1080451 NP_839393.1 CDS yhiO NC_004741.1 4158446 4158781 D ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 4158446..4158781 Shigella flexneri 2a str. 2457T 1080452 NP_839394.1 CDS pitA NC_004741.1 4158852 4160351 R residues 26 to 499 of 499 are 96.41 pct identical to residues 26 to 499 of 499 from Escherichia coli K-12 : B3493; low-affinity phosphate transport protein complement(4158852..4160351) Shigella flexneri 2a str. 2457T 1080453 NP_839395.1 CDS yhiN NC_004741.1 4160583 4161782 D residues 1 to 394 of 399 are 94.41 pct identical to residues 1 to 394 of 400 from Escherichia coli K-12 : B3492; hypothetical protein 4160583..4161782 Shigella flexneri 2a str. 2457T 1078409 NP_839396.1 CDS S4246 NC_004741.1 4162311 4162586 D residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4162311..4162586 Shigella flexneri 2a str. 2457T 1080454 NP_839397.1 CDS S4247 NC_004741.1 4162505 4163008 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 4162505..4163008 Shigella flexneri 2a str. 2457T 1080457 NP_839398.1 CDS S4248 NC_004741.1 4163019 4163318 R residues 1 to 98 of 99 are 100.00 pct identical to residues 1 to 98 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA complement(4163019..4163318) Shigella flexneri 2a str. 2457T 1080458 NP_839399.1 CDS S4249 NC_004741.1 4163583 4164608 D residues 1 to 334 of 341 are 22.65 pct identical to residues 229 to 570 of 597 from GenPept : >gb|AAF93566.1| (AE004127) hypothetical protein [Vibrio cholerae]; hypothetical protein 4163583..4164608 Shigella flexneri 2a str. 2457T 1080459 NP_839400.1 CDS S4250 NC_004741.1 4166011 4166571 D residues 1 to 177 of 186 are 47.54 pct identical to residues 59 to 239 of 241 from GenPept : >gb|AAD26595.1| (AF012835) chaperone protein AafD [Escherichia coli]; chaperone 4166011..4166571 Shigella flexneri 2a str. 2457T 1080461 NP_839401.1 CDS S4254 NC_004741.1 4166615 4167694 D residues 20 to 356 of 359 are 41.78 pct identical to residues 29 to 375 of 856 from NRprotein_Feb2003 : >gb|AAD27810.1|AF114828_2 aggregative adherence fimbria II usher protein AafC [Escherichia coli]; similar to several fimbrial proteins; fimbrial protein remnant 4166615..4167694 Shigella flexneri 2a str. 2457T 1078396 NP_839402.2 CDS S4252 NC_004741.1 4167949 4168854 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(4167949..4168854) Shigella flexneri 2a str. 2457T 1080462 NP_839403.2 CDS S4253 NC_004741.1 4168812 4169177 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(4168812..4169177) Shigella flexneri 2a str. 2457T 1076438 NP_839404.1 CDS S4255 NC_004741.1 4170556 4171068 D no significant similarities; hypothetical protein 4170556..4171068 Shigella flexneri 2a str. 2457T 1080463 NP_839405.1 CDS S4836 NC_004741.1 4171175 4171936 R residues 1 to 253 of 253 are 100.00 pct identical to residues 1 to 253 of 253 from NRprotein_Feb03 : >ref|NP_709260.1| orf, hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN44967.1|AE015359_3 orf, hypothetical protein [Shigella flexneri 2a str. 301]; similar to response regulators; hypothetical protein complement(4171175..4171936) Shigella flexneri 2a str. 2457T 1080464 NP_839406.1 CDS S4837 NC_004741.1 4172182 4172946 D residues 1 to 254 of 254 are 100.00 pct identical to residues 1 to 254 of 254 from NRprotein_Feb03 : >ref|NP_709259.1| orf, partial conserved hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN44966.1|AE015359_2 orf, partial conserved hypothetical protein [Shigella flexneri 2a str. 301]; hypothetical protein 4172182..4172946 Shigella flexneri 2a str. 2457T 1080465 NP_839407.1 CDS S4838 NC_004741.1 4172900 4173415 D residues 1 to 171 of 171 are 100.00 pct identical to residues 1 to 171 of 171 from NRprotein_Feb03 : >ref|NP_709258.1| orf, hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN44965.1|AE015359_1 orf, hypothetical protein [Shigella flexneri 2a str. 301]; hypothetical protein 4172900..4173415 Shigella flexneri 2a str. 2457T 1080466 NP_839408.1 CDS yhiJ NC_004741.1 4176769 4178391 D residues 1 to 540 of 540 are 97.22 pct identical to residues 1 to 540 of 540 from Escherichia coli K-12 : B3488; hypothetical protein 4176769..4178391 Shigella flexneri 2a str. 2457T 1080470 NP_839409.1 CDS yhiI NC_004741.1 4178757 4179824 D residues 1 to 355 of 355 are 80.00 pct identical to residues 1 to 355 of 355 from Escherichia coli K-12 : B3487; hypothetical protein 4178757..4179824 Shigella flexneri 2a str. 2457T 1080471 NP_839410.1 CDS yhiH NC_004741.1 4179821 4182556 D residues 18 to 911 of 911 are 94.63 pct identical to residues 1 to 894 of 894 from Escherichia coli K-12 : B3486; ATP-binding component of a transport system 4179821..4182556 Shigella flexneri 2a str. 2457T 1080472 NP_839411.1 CDS yhhJ NC_004741.1 4182556 4183680 D residues 1 to 374 of 374 are 88.77 pct identical to residues 2 to 375 of 375 from Escherichia coli K-12 : B3485; transporter 4182556..4183680 Shigella flexneri 2a str. 2457T 1080473 NP_839412.1 CDS S4263 NC_004741.1 4184011 4184370 D residues 1 to 119 of 119 are 99.15 pct identical to residues 1 to 119 of 119 from GenPept : >gb|AAG58616.1|AE005572_14 (AE005572) Z4882 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 4184011..4184370 Shigella flexneri 2a str. 2457T 1080474 NP_839413.1 CDS yhhG NC_004741.1 4184490 4184891 R Inhibits transcription at high concentrations of nickel; nickel responsive regulator complement(4184490..4184891) Shigella flexneri 2a str. 2457T 1080475 NP_839414.1 CDS nikE NC_004741.1 4184897 4185703 R with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE complement(4184897..4185703) Shigella flexneri 2a str. 2457T 1080476 NP_839415.1 CDS nikD NC_004741.1 4185700 4186464 R with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD complement(4185700..4186464) Shigella flexneri 2a str. 2457T 1080477 NP_839416.1 CDS nikC NC_004741.1 4186464 4187297 R with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC complement(4186464..4187297) Shigella flexneri 2a str. 2457T 1080478 NP_839417.1 CDS nikB NC_004741.1 4187294 4188238 R with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB complement(4187294..4188238) Shigella flexneri 2a str. 2457T 1079684 NP_839418.1 CDS nikA NC_004741.1 4188238 4189812 R residues 1 to 524 of 524 are 99.42 pct identical to residues 1 to 524 of 524 from Escherichia coli K-12 : B3476; periplasmic binding protein for nickel complement(4188238..4189812) Shigella flexneri 2a str. 2457T 1080480 NP_839419.1 CDS yhhU NC_004741.1 4189923 4190510 R residues 1 to 195 of 195 are 98.46 pct identical to residues 1 to 195 of 195 from Escherichia coli K-12 : B3475; holo-(acyl carrier protein) synthase 2 complement(4189923..4190510) Shigella flexneri 2a str. 2457T 1080481 NP_839420.1 CDS yhhT NC_004741.1 4190565 4191614 R residues 1 to 349 of 349 are 95.98 pct identical to residues 28 to 376 of 376 from Escherichia coli K-12 : B3474; hypothetical protein complement(4190565..4191614) Shigella flexneri 2a str. 2457T 1077976 NP_839421.2 CDS yhhS NC_004741.1 4191748 4192965 D residues 30 to 387 of 419 are 37.70 pct identical to residues 14 to 371 of 392 from Escherichia coli K-12 : B2322; major facilitator superfamily transporter 4191748..4192965 Shigella flexneri 2a str. 2457T 1080482 NP_839422.2 CDS S4273 NC_004741.1 4192969 4193526 R residues 1 to 203 of 203 are 100.00 pct identical to residues 1 to 203 of 203 from Escherichia coli K-12 : B3472; hypothetical protein complement(4192969..4193526) Shigella flexneri 2a str. 2457T 1080483 NP_839423.1 CDS yhhQ NC_004741.1 4193599 4194264 R residues 1 to 221 of 221 are 99.54 pct identical to residues 1 to 221 of 221 from Escherichia coli K-12 : B3471; hypothetical protein complement(4193599..4194264) Shigella flexneri 2a str. 2457T 1080484 NP_839424.1 CDS yhhP NC_004741.1 4194485 4194730 D TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 4194485..4194730 Shigella flexneri 2a str. 2457T 1078182 NP_839425.1 CDS zntA NC_004741.1 4194832 4197030 R P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase complement(4194832..4197030) Shigella flexneri 2a str. 2457T 1080485 NP_839426.1 CDS yhhN NC_004741.1 4197104 4197730 R residues 1 to 208 of 208 are 88.46 pct identical to residues 1 to 208 of 208 from Escherichia coli K-12 : B3468; enzyme complement(4197104..4197730) Shigella flexneri 2a str. 2457T 1080486 NP_839427.1 CDS yhhM NC_004741.1 4197871 4198230 D residues 1 to 119 of 119 are 89.07 pct identical to residues 1 to 119 of 119 from Escherichia coli K-12 : B3467; receptor 4197871..4198230 Shigella flexneri 2a str. 2457T 1080487 NP_839428.1 CDS yhhL NC_004741.1 4198233 4198502 R residues 1 to 89 of 89 are 98.87 pct identical to residues 1 to 89 of 89 from Escherichia coli K-12 : B3466; hypothetical protein complement(4198233..4198502) Shigella flexneri 2a str. 2457T 1080488 NP_839429.1 CDS rsmD NC_004741.1 4198492 4199088 R catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase complement(4198492..4199088) Shigella flexneri 2a str. 2457T 1077575 NP_839430.1 CDS ftsY NC_004741.1 4199238 4200734 D signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 4199238..4200734 Shigella flexneri 2a str. 2457T 1080489 NP_839431.1 CDS ftsE NC_004741.1 4200737 4201405 D ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 4200737..4201405 Shigella flexneri 2a str. 2457T 1080490 NP_839432.1 CDS ftsX NC_004741.1 4201398 4202456 D ABC transporter membrane protein; cell division protein FtsX 4201398..4202456 Shigella flexneri 2a str. 2457T 1080491 NP_839433.1 CDS rpoH NC_004741.1 4202701 4203555 D binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 4202701..4203555 Shigella flexneri 2a str. 2457T 1080492 NP_839434.1 CDS livJ NC_004741.1 4203769 4204929 D residues 1 to 386 of 386 are 97.15 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 : B3460; high-affinity amino acid transport protein, periplasmic binding protein 4203769..4204929 Shigella flexneri 2a str. 2457T 1080493 NP_839435.1 CDS yhhK NC_004741.1 4205128 4205511 R residues 1 to 126 of 127 are 89.68 pct identical to residues 1 to 126 of 127 from Escherichia coli K-12 : B3459; hypothetical protein complement(4205128..4205511) Shigella flexneri 2a str. 2457T 1078285 NP_839436.1 CDS livK NC_004741.1 4205935 4207044 D residues 1 to 369 of 369 are 99.72 pct identical to residues 1 to 369 of 369 from Escherichia coli K-12 : B3458; high-affinity leucine-specific transport protein, periplasmic binding protein 4205935..4207044 Shigella flexneri 2a str. 2457T 1080494 NP_839437.1 CDS livH NC_004741.1 4207092 4208018 D LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid ABC transporter permease 4207092..4208018 Shigella flexneri 2a str. 2457T 1076553 NP_839438.1 CDS livM NC_004741.1 4208015 4209292 D Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit 4208015..4209292 Shigella flexneri 2a str. 2457T 1080495 NP_839439.1 CDS livG NC_004741.1 4209289 4210056 D Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 4209289..4210056 Shigella flexneri 2a str. 2457T 1080496 NP_839440.1 CDS livF NC_004741.1 4210058 4210771 D with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 4210058..4210771 Shigella flexneri 2a str. 2457T 1080497 NP_839441.1 CDS ugpB NC_004741.1 4211168 4212484 D with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein 4211168..4212484 Shigella flexneri 2a str. 2457T 1080498 NP_839442.1 CDS ugpA NC_004741.1 4212582 4213469 D with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 4212582..4213469 Shigella flexneri 2a str. 2457T 1080499 NP_839443.1 CDS ugpE NC_004741.1 4213466 4214311 D with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 4213466..4214311 Shigella flexneri 2a str. 2457T 1080500 NP_839444.1 CDS ugpQ NC_004741.1 4215300 4216043 D hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; glycerophosphodiester phosphodiesterase 4215300..4216043 Shigella flexneri 2a str. 2457T 1080502 NP_839445.1 CDS yhhA NC_004741.1 4216030 4216470 R residues 1 to 146 of 146 are 71.23 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 : B3448; hypothetical protein complement(4216030..4216470) Shigella flexneri 2a str. 2457T 1080504 NP_839446.1 CDS ggt NC_004741.1 4216590 4218332 D periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 4216590..4218332 Shigella flexneri 2a str. 2457T 1080506 NP_839447.1 CDS yhhY NC_004741.1 4218391 4218879 R YhhY; regulated by the fur regulator; unknown function; acetyltransferase YhhY complement(4218391..4218879) Shigella flexneri 2a str. 2457T 1080507 NP_839448.1 CDS yhhX NC_004741.1 4219212 4220249 D residues 1 to 344 of 345 are 99.70 pct identical to residues 1 to 344 of 345 from Escherichia coli K-12 : B3440; dehydrogenase 4219212..4220249 Shigella flexneri 2a str. 2457T 1080508 NP_839449.1 CDS yhhW NC_004741.1 4220372 4221067 D residues 1 to 231 of 231 are 99.56 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 : B3439; hypothetical protein 4220372..4221067 Shigella flexneri 2a str. 2457T 1080509 NP_839450.1 CDS gntR NC_004741.1 4221348 4222286 D residues 1 to 285 of 312 are 97.54 pct identical to residues 20 to 304 of 313 from Escherichia coli K-12 : B3438; regulator of gluconate (gnt) operon 4221348..4222286 Shigella flexneri 2a str. 2457T 1080510 NP_839451.2 CDS gntK NC_004741.1 4222425 4222952 D thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 4222425..4222952 Shigella flexneri 2a str. 2457T 1078250 NP_839452.1 CDS gntU NC_004741.1 4223019 4224296 D residues 1 to 425 of 425 are 99.52 pct identical to residues 22 to 446 of 446 from NRprotein_Feb2003 : >ref|NP_289984.1| low-affinity gluconate permease [Escherichia coli O157:H7 EDL933] ref|NP_417893.1| H+/gluconate symporter [Escherichia coli K12] sp|P46858|GNTU_ECOLI Low-affinity gluconate transporter (Gluconate permease)[Escherichia coli]; low affinity gluconate transporter 4223019..4224296 Shigella flexneri 2a str. 2457T 1080511 NP_839453.1 CDS yhgN NC_004741.1 4224353 4224946 R YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase complement(4224353..4224946) Shigella flexneri 2a str. 2457T 1080512 NP_839454.1 CDS asd NC_004741.1 4225138 4226241 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 4225138..4226241 Shigella flexneri 2a str. 2457T 1080513 NP_839455.1 CDS glgB NC_004741.1 4226514 4228700 D catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 4226514..4228700 Shigella flexneri 2a str. 2457T 1080514 NP_839456.1 CDS glgX NC_004741.1 4228697 4230670 D catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme 4228697..4230670 Shigella flexneri 2a str. 2457T 1080515 NP_839457.1 CDS glgC NC_004741.1 4230688 4231983 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 4230688..4231983 Shigella flexneri 2a str. 2457T 1080516 NP_839458.1 CDS glgA NC_004741.1 4231983 4233416 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 4231983..4233416 Shigella flexneri 2a str. 2457T 1080517 NP_839459.1 CDS glgP NC_004741.1 4233435 4235882 D residues 1 to 815 of 815 are 97.30 pct identical to residues 1 to 815 of 815 from Escherichia coli K-12 : B3428; glycogen phosphorylase 4233435..4235882 Shigella flexneri 2a str. 2457T 1080518 NP_839460.1 CDS S4313 NC_004741.1 4236000 4236866 D residues 1 to 284 of 288 are 98.94 pct identical to residues 7 to 290 of 439 from GenPept : >gb|AAK18553.1|AF348706_242 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 4236000..4236866 Shigella flexneri 2a str. 2457T 1080519 NP_839461.1 CDS S4314 NC_004741.1 4236872 4237327 D residues 1 to 151 of 151 are 99.33 pct identical to residues 298 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 4236872..4237327 Shigella flexneri 2a str. 2457T 1080520 NP_839462.1 CDS glpD NC_004741.1 4237934 4239412 R in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase complement(4237934..4239412) Shigella flexneri 2a str. 2457T 1080522 NP_839463.1 CDS glpE NC_004741.1 4239630 4239956 D belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 4239630..4239956 Shigella flexneri 2a str. 2457T 1080921 NP_839464.1 CDS glpG NC_004741.1 4240007 4240831 D protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 4240007..4240831 Shigella flexneri 2a str. 2457T 1080967 NP_839465.1 CDS glpR NC_004741.1 4240848 4241606 D represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 4240848..4241606 Shigella flexneri 2a str. 2457T 1080523 NP_839466.1 CDS rtcR NC_004741.1 4241588 4243186 R residues 1 to 532 of 532 are 98.68 pct identical to residues 1 to 532 of 532 from Escherichia coli K-12 : B3422; 2-component regulator complement(4241588..4243186) Shigella flexneri 2a str. 2457T 1080524 NP_839467.1 CDS rtcB NC_004741.1 4243367 4244593 D residues 1 to 408 of 408 are 98.28 pct identical to residues 1 to 408 of 408 from Escherichia coli K-12 : B3421; hypothetical protein 4243367..4244593 Shigella flexneri 2a str. 2457T 1080525 NP_839468.1 CDS yhgJ NC_004741.1 4245008 4245613 D catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 4245008..4245613 Shigella flexneri 2a str. 2457T 1080527 NP_839469.1 CDS malP NC_004741.1 4248973 4251366 D residues 1 to 797 of 797 are 94.47 pct identical to residues 1 to 797 of 797 from Escherichia coli K-12 : B3417; maltodextrin phosphorylase 4248973..4251366 Shigella flexneri 2a str. 2457T 1080529 NP_839470.1 CDS malQ NC_004741.1 4251376 4253460 D amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 4251376..4253460 Shigella flexneri 2a str. 2457T 1080530 NP_839471.1 CDS gntT NC_004741.1 4253505 4254821 R residues 17 to 438 of 438 are 88.38 pct identical to residues 17 to 437 of 437 from Escherichia coli K-12 : B3415; high-affinity transport permease for gluconate complement(4253505..4254821) Shigella flexneri 2a str. 2457T 1080532 NP_839472.1 CDS yhgI NC_004741.1 4255182 4255757 R cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein complement(4255182..4255757) Shigella flexneri 2a str. 2457T 1080533 NP_839473.2 CDS yhgH NC_004741.1 4255816 4256499 R involved in high-affinity gluconate transport; gluconate periplasmic binding protein complement(4255816..4256499) Shigella flexneri 2a str. 2457T 1080534 NP_839474.1 CDS bioH NC_004741.1 4256537 4257325 D Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 4256537..4257325 Shigella flexneri 2a str. 2457T 1080535 NP_839475.2 CDS S4331 NC_004741.1 4258051 4258956 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(4258051..4258956) Shigella flexneri 2a str. 2457T 1080536 NP_839476.2 CDS S4332 NC_004741.1 4258914 4259279 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(4258914..4259279) Shigella flexneri 2a str. 2457T 1080537 NP_839477.1 CDS yhgA NC_004741.1 4259355 4260242 R residues 1 to 281 of 295 are 99.28 pct identical to residues 1 to 281 of 292 from Escherichia coli K-12 : B3411; hypothetical protein complement(4259355..4260242) Shigella flexneri 2a str. 2457T 1080538 NP_839478.1 CDS yhgG NC_004741.1 4260445 4260681 R residues 1 to 78 of 78 are 98.71 pct identical to residues 1 to 78 of 78 from Escherichia coli K-12 : B3410; hypothetical protein complement(4260445..4260681) Shigella flexneri 2a str. 2457T 1080539 NP_839479.1 CDS feoB NC_004741.1 4260681 4263002 R cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B complement(4260681..4263002) Shigella flexneri 2a str. 2457T 1080540 NP_839480.1 CDS feoA NC_004741.1 4263019 4263246 R residues 1 to 75 of 75 are 98.66 pct identical to residues 1 to 75 of 75 from Escherichia coli K-12 : B3408; ferrous iron transport protein A complement(4263019..4263246) Shigella flexneri 2a str. 2457T 1080541 NP_839481.1 CDS yhgF NC_004741.1 4263684 4265906 R residues 1 to 740 of 740 are 97.56 pct identical to residues 1 to 740 of 740 from Escherichia coli K-12 : B3407; hypothetical protein complement(4263684..4265906) Shigella flexneri 2a str. 2457T 1080542 NP_839482.2 CDS greB NC_004741.1 4266102 4266578 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB complement(4266102..4266578) Shigella flexneri 2a str. 2457T 1080543 NP_839483.1 CDS ompR NC_004741.1 4266806 4267525 D part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 4266806..4267525 Shigella flexneri 2a str. 2457T 1080544 NP_839484.1 CDS envZ NC_004741.1 4267522 4268874 D membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 4267522..4268874 Shigella flexneri 2a str. 2457T 1080545 NP_839485.1 CDS pckA NC_004741.1 4268950 4270572 R PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase complement(4268950..4270572) Shigella flexneri 2a str. 2457T 1080546 NP_839486.1 CDS yhgE NC_004741.1 4270951 4272702 D residues 1 to 583 of 583 are 79.24 pct identical to residues 1 to 574 of 574 from Escherichia coli K-12 : B3402; transporter 4270951..4272702 Shigella flexneri 2a str. 2457T 1080547 NP_839487.1 CDS hslO NC_004741.1 4272846 4273715 R becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin complement(4272846..4273715) Shigella flexneri 2a str. 2457T 1080548 NP_839488.1 CDS yrfH NC_004741.1 4273740 4274141 R residues 1 to 133 of 133 are 87.96 pct identical to residues 1 to 133 of 133 from Escherichia coli K-12 : B3400; ribosome-associated heat shock protein Hsp15 complement(4273740..4274141) Shigella flexneri 2a str. 2457T 1080550 NP_839489.1 CDS yrfG NC_004741.1 4274152 4274865 R residues 1 to 237 of 237 are 100.00 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B3399; phosphatase complement(4274152..4274865) Shigella flexneri 2a str. 2457T 1080551 NP_839490.1 CDS yrfF NC_004741.1 4274885 4277020 R residues 1 to 711 of 711 are 93.81 pct identical to residues 1 to 711 of 711 from Escherichia coli K-12 : B3398; dehydrogenase complement(4274885..4277020) Shigella flexneri 2a str. 2457T 1080552 NP_839491.1 CDS nudE NC_004741.1 4277340 4277900 D ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 4277340..4277900 Shigella flexneri 2a str. 2457T 1079335 NP_839492.3 CDS mrcA NC_004741.1 4278065 4280617 R bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase complement(4278065..4280617) Shigella flexneri 2a str. 2457T 1080554 NP_839493.1 CDS yrfD NC_004741.1 4280710 4281516 D residues 1 to 268 of 268 are 93.28 pct identical to residues 1 to 268 of 268 from Escherichia coli K-12 : B3395; hypothetical protein 4280710..4281516 Shigella flexneri 2a str. 2457T 1080556 NP_839494.1 CDS yrfC NC_004741.1 4281516 4282055 D residues 1 to 179 of 179 are 80.44 pct identical to residues 1 to 179 of 179 from Escherichia coli K-12 : B3394; hypothetical protein 4281516..4282055 Shigella flexneri 2a str. 2457T 1080557 NP_839495.1 CDS yrfB NC_004741.1 4282039 4282479 D residues 1 to 146 of 146 are 97.94 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 : B3393; hypothetical protein 4282039..4282479 Shigella flexneri 2a str. 2457T 1080559 NP_839496.1 CDS hofQ NC_004741.1 4282787 4284025 D outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ 4282787..4284025 Shigella flexneri 2a str. 2457T 1080561 NP_839497.2 CDS aroK NC_004741.1 4284426 4284947 D type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 4284426..4284947 Shigella flexneri 2a str. 2457T 1080562 NP_839498.1 CDS aroB NC_004741.1 4285004 4286092 D catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 4285004..4286092 Shigella flexneri 2a str. 2457T 1079948 NP_839499.1 CDS damX NC_004741.1 4286184 4287476 D residues 1 to 430 of 430 are 61.39 pct identical to residues 1 to 428 of 428 from Escherichia coli K-12 : B3388; interferes with cell division; hypothetical protein 4286184..4287476 Shigella flexneri 2a str. 2457T 1080563 NP_839500.1 CDS dam NC_004741.1 4287583 4288419 D residues 1 to 278 of 278 are 99.64 pct identical to residues 1 to 278 of 278 from Escherichia coli K-12 : B3387; DNA adenine methylase 4287583..4288419 Shigella flexneri 2a str. 2457T 1076430 NP_839501.1 CDS rpe NC_004741.1 4288437 4289114 D catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 4288437..4289114 Shigella flexneri 2a str. 2457T 1080564 NP_839502.1 CDS gph NC_004741.1 4289107 4289865 D catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 4289107..4289865 Shigella flexneri 2a str. 2457T 1080565 NP_839503.1 CDS trpS NC_004741.1 4289858 4290862 D catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 4289858..4290862 Shigella flexneri 2a str. 2457T 1080566 NP_839504.1 CDS yhfZ NC_004741.1 4291351 4292037 D residues 1 to 228 of 228 are 96.49 pct identical to residues 1 to 228 of 228 from Escherichia coli K-12 : B3383; hypothetical protein 4291351..4292037 Shigella flexneri 2a str. 2457T 1080567 NP_839505.1 CDS yhfY NC_004741.1 4292012 4292416 D residues 1 to 134 of 134 are 96.26 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B3382; hypothetical protein 4292012..4292416 Shigella flexneri 2a str. 2457T 1080568 NP_839506.1 CDS yhfX NC_004741.1 4292500 4293663 D residues 1 to 387 of 387 are 91.47 pct identical to residues 1 to 387 of 387 from Escherichia coli K-12 : B3381; hypothetical protein 4292500..4293663 Shigella flexneri 2a str. 2457T 1080570 NP_839507.1 CDS yhfW NC_004741.1 4293664 4294890 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; mutase 4293664..4294890 Shigella flexneri 2a str. 2457T 1080571 NP_839508.1 CDS yhfV NC_004741.1 4294887 4295765 D phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); hydrolase 4294887..4295765 Shigella flexneri 2a str. 2457T 1080572 NP_839509.1 CDS yhfU NC_004741.1 4295737 4296129 D residues 1 to 130 of 130 are 100.00 pct identical to residues 1 to 130 of 130 from Escherichia coli K-12 : B3378; hypothetical protein 4295737..4296129 Shigella flexneri 2a str. 2457T 1080573 NP_839510.1 CDS yhfT NC_004741.1 4296141 4297445 D residues 1 to 434 of 434 are 93.08 pct identical to residues 1 to 434 of 434 from Escherichia coli K-12 : B3377; transport system permease 4296141..4297445 Shigella flexneri 2a str. 2457T 1080574 NP_839511.1 CDS yhfS NC_004741.1 4297457 4298542 D residues 1 to 361 of 361 are 86.70 pct identical to residues 1 to 361 of 361 from Escherichia coli K-12 : B3376; hypothetical protein 4297457..4298542 Shigella flexneri 2a str. 2457T 1080575 NP_839512.1 CDS yhfR NC_004741.1 4298702 4299499 R may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR complement(4298702..4299499) Shigella flexneri 2a str. 2457T 1080577 NP_839513.1 CDS yhfQ NC_004741.1 4299533 4300318 R residues 1 to 261 of 261 are 99.23 pct identical to residues 1 to 261 of 261 from Escherichia coli K-12 : B3374; fructoselysine 6-kinase complement(4299533..4300318) Shigella flexneri 2a str. 2457T 1080578 NP_839514.1 CDS yhfP NC_004741.1 4300315 4301145 R YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase complement(4300315..4301145) Shigella flexneri 2a str. 2457T 1080579 NP_839515.2 CDS frlB NC_004741.1 4301195 4302238 R catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase complement(4301195..4302238) Shigella flexneri 2a str. 2457T 1080581 NP_839516.1 CDS yhfL NC_004741.1 4303870 4304037 R residues 1 to 55 of 55 are 70.90 pct identical to residues 1 to 55 of 55 from Escherichia coli K-12 : B3369; hypothetical protein complement(4303870..4304037) Shigella flexneri 2a str. 2457T 1080583 NP_839517.1 CDS cysG NC_004741.1 4304284 4305657 R multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase complement(4304284..4305657) Shigella flexneri 2a str. 2457T 1080584 NP_839518.1 CDS nirC NC_004741.1 4305676 4306230 R residues 1 to 184 of 184 are 100.00 pct identical to residues 1 to 184 of 184 from Escherichia coli K-12 : B3367; nitrite reductase, NirC protein complement(4305676..4306230) Shigella flexneri 2a str. 2457T 1080585 NP_839519.1 CDS nirD NC_004741.1 4306608 4306934 R involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit complement(4306608..4306934) Shigella flexneri 2a str. 2457T 1080586 NP_839520.1 CDS nirB NC_004741.1 4306931 4309474 R residues 1 to 847 of 847 are 97.87 pct identical to residues 1 to 847 of 847 from Escherichia coli K-12 : B3365; nitrite reductase (NAD(P)H) subunit complement(4306931..4309474) Shigella flexneri 2a str. 2457T 1080587 NP_839521.1 CDS yhfC NC_004741.1 4309736 4310917 R residues 1 to 393 of 393 are 98.72 pct identical to residues 1 to 393 of 393 from Escherichia coli K-12 : B3364; hypothetical protein complement(4309736..4310917) Shigella flexneri 2a str. 2457T 1080588 NP_839522.1 CDS ppiA NC_004741.1 4311188 4311769 D residues 29 to 193 of 193 are 100.00 pct identical to residues 26 to 190 of 190 from Escherichia coli K-12 : B3363; peptidyl-prolyl cis-trans isomerase A (rotamase A) 4311188..4311769 Shigella flexneri 2a str. 2457T 1080589 NP_839523.1 CDS yhfG NC_004741.1 4311874 4312041 D residues 1 to 36 of 55 are 100.00 pct identical to residues 1 to 36 of 55 from Escherichia coli K-12 : B3362; hypothetical protein 4311874..4312041 Shigella flexneri 2a str. 2457T 1080590 NP_839524.1 CDS fic NC_004741.1 4312031 4312633 D residues 1 to 200 of 200 are 92.50 pct identical to residues 1 to 200 of 200 from Escherichia coli K-12 : B3361; recognized by rpoS, affects cell division; cell filamentation protein Fic 4312031..4312633 Shigella flexneri 2a str. 2457T 1080591 NP_839525.1 CDS pabA NC_004741.1 4312665 4313228 D aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 4312665..4313228 Shigella flexneri 2a str. 2457T 1080592 NP_839526.1 CDS argD NC_004741.1 4313314 4314534 D DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein 4313314..4314534 Shigella flexneri 2a str. 2457T 1080593 NP_839527.1 CDS yhfK NC_004741.1 4314601 4316691 R residues 1 to 696 of 696 are 94.68 pct identical to residues 1 to 696 of 696 from Escherichia coli K-12 : B3358; hypothetical protein complement(4314601..4316691) Shigella flexneri 2a str. 2457T 1080594 NP_839528.1 CDS crp NC_004741.1 4316742 4317374 R complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein complement(4316742..4317374) Shigella flexneri 2a str. 2457T 1080595 NP_839529.1 CDS yhfA NC_004741.1 4317676 4318080 D residues 1 to 134 of 134 are 100.00 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B3356; hypothetical protein 4317676..4318080 Shigella flexneri 2a str. 2457T 1080596 NP_839530.1 CDS prkB NC_004741.1 4318135 4319004 R residues 1 to 289 of 289 are 95.84 pct identical to residues 1 to 289 of 289 from Escherichia coli K-12 : B3355; phosphoribulokinase complement(4318135..4319004) Shigella flexneri 2a str. 2457T 1080597 NP_839531.1 CDS yheU NC_004741.1 4319058 4319276 R residues 1 to 72 of 72 are 100.00 pct identical to residues 1 to 72 of 72 from Escherichia coli K-12 : B3354; hypothetical protein complement(4319058..4319276) Shigella flexneri 2a str. 2457T 1080598 NP_839532.1 CDS yheT NC_004741.1 4319270 4320292 R residues 1 to 340 of 340 are 93.23 pct identical to residues 1 to 340 of 340 from Escherichia coli K-12 : B3353; hydrolase complement(4319270..4320292) Shigella flexneri 2a str. 2457T 1080599 NP_839533.1 CDS yheS NC_004741.1 4320292 4322205 R residues 1 to 620 of 637 are 99.67 pct identical to residues 1 to 620 of 637 from Escherichia coli K-12 : B3352; ABC transporter ATP-binding protein complement(4320292..4322205) Shigella flexneri 2a str. 2457T 1080600 NP_839534.1 CDS yheR NC_004741.1 4322336 4322887 D required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 4322336..4322887 Shigella flexneri 2a str. 2457T 1080601 NP_839535.1 CDS kefB NC_004741.1 4322963 4324624 D involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB 4322963..4324624 Shigella flexneri 2a str. 2457T 1080602 NP_839536.1 CDS slyD NC_004741.1 4324929 4325519 D rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 4324929..4325519 Shigella flexneri 2a str. 2457T 1080603 NP_839537.1 CDS slyX NC_004741.1 4325568 4325786 R residues 1 to 72 of 72 are 77.77 pct identical to residues 1 to 72 of 72 from Escherichia coli K-12 : B3348; hypothetical protein complement(4325568..4325786) Shigella flexneri 2a str. 2457T 1080604 NP_839538.1 CDS fkpA NC_004741.1 4326007 4326819 D rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 4326007..4326819 Shigella flexneri 2a str. 2457T 1080605 NP_839539.1 CDS yheO NC_004741.1 4326986 4327708 D residues 1 to 240 of 240 are 100.00 pct identical to residues 5 to 244 of 244 from Escherichia coli K-12 : B3346; hypothetical protein 4326986..4327708 Shigella flexneri 2a str. 2457T 1080606 NP_839540.1 CDS yheN NC_004741.1 4327708 4328094 D in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 4327708..4328094 Shigella flexneri 2a str. 2457T 1080607 NP_839541.1 CDS yheM NC_004741.1 4328094 4328453 D in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 4328094..4328453 Shigella flexneri 2a str. 2457T 1080608 NP_839542.1 CDS yheL NC_004741.1 4328461 4328748 D in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 4328461..4328748 Shigella flexneri 2a str. 2457T 1080791 NP_839543.1 CDS rpsL NC_004741.1 4328874 4329248 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 4328874..4329248 Shigella flexneri 2a str. 2457T 1080974 NP_839544.1 CDS rpsG NC_004741.1 4329345 4329815 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 4329345..4329815 Shigella flexneri 2a str. 2457T 1080609 NP_839545.1 CDS fusA NC_004741.1 4330060 4332027 D Promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome; elongation factor EF-2 4330060..4332027 Shigella flexneri 2a str. 2457T 1080610 NP_839546.1 CDS tuf NC_004741.1 4332098 4333282 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4332098..4333282 Shigella flexneri 2a str. 2457T 1080611 NP_839547.1 CDS yheA NC_004741.1 4333465 4333659 D residues 1 to 64 of 64 are 87.50 pct identical to residues 1 to 64 of 64 from Escherichia coli K-12 : B3337; bacterioferritin-associated ferredoxin 4333465..4333659 Shigella flexneri 2a str. 2457T 1080612 NP_839548.1 CDS bfr NC_004741.1 4333732 4334208 D iron storage protein; bacterioferritin 4333732..4334208 Shigella flexneri 2a str. 2457T 1080613 NP_839549.1 CDS rpsJ NC_004741.1 4335051 4335362 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 4335051..4335362 Shigella flexneri 2a str. 2457T 1080615 NP_839550.1 CDS rplC NC_004741.1 4335395 4336024 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 4335395..4336024 Shigella flexneri 2a str. 2457T 1080616 NP_839551.1 CDS rplD NC_004741.1 4336035 4336640 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 4336035..4336640 Shigella flexneri 2a str. 2457T 1080617 NP_839552.1 CDS rplW NC_004741.1 4336637 4336939 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 4336637..4336939 Shigella flexneri 2a str. 2457T 1080618 NP_839553.1 CDS rplB NC_004741.1 4336957 4337778 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 4336957..4337778 Shigella flexneri 2a str. 2457T 1080619 NP_839554.1 CDS rpsS NC_004741.1 4337795 4338073 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 4337795..4338073 Shigella flexneri 2a str. 2457T 1080620 NP_839555.1 CDS rplV NC_004741.1 4338088 4338420 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 4338088..4338420 Shigella flexneri 2a str. 2457T 1080621 NP_839556.1 CDS rpsC NC_004741.1 4338438 4339139 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 4338438..4339139 Shigella flexneri 2a str. 2457T 1080622 NP_839557.1 CDS rplP NC_004741.1 4339152 4339562 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 4339152..4339562 Shigella flexneri 2a str. 2457T 1080623 NP_839558.1 CDS rpmC NC_004741.1 4339562 4339753 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 4339562..4339753 Shigella flexneri 2a str. 2457T 1080624 NP_839559.1 CDS rpsQ NC_004741.1 4339753 4340007 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 4339753..4340007 Shigella flexneri 2a str. 2457T 1080625 NP_839560.1 CDS rplN NC_004741.1 4340172 4340543 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 4340172..4340543 Shigella flexneri 2a str. 2457T 1080626 NP_839561.1 CDS rplX NC_004741.1 4340554 4340868 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 4340554..4340868 Shigella flexneri 2a str. 2457T 1080627 NP_839562.1 CDS rplE NC_004741.1 4340883 4341422 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 4340883..4341422 Shigella flexneri 2a str. 2457T 1080628 NP_839563.1 CDS rpsN NC_004741.1 4341437 4341742 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 4341437..4341742 Shigella flexneri 2a str. 2457T 1080629 NP_839564.1 CDS rpsH NC_004741.1 4341776 4342168 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 4341776..4342168 Shigella flexneri 2a str. 2457T 1080630 NP_839565.1 CDS rplF NC_004741.1 4342181 4342714 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 4342181..4342714 Shigella flexneri 2a str. 2457T 1080631 NP_839566.1 CDS rplR NC_004741.1 4342724 4343077 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 4342724..4343077 Shigella flexneri 2a str. 2457T 1080632 NP_839567.1 CDS rpsE NC_004741.1 4343092 4343595 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 4343092..4343595 Shigella flexneri 2a str. 2457T 1080633 NP_839568.1 CDS rpmD NC_004741.1 4343599 4343778 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 4343599..4343778 Shigella flexneri 2a str. 2457T 1080634 NP_839569.1 CDS rplO NC_004741.1 4343782 4344216 D late assembly protein; 50S ribosomal protein L15 4343782..4344216 Shigella flexneri 2a str. 2457T 1080635 NP_839570.1 CDS secY NC_004741.1 4344224 4345555 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 4344224..4345555 Shigella flexneri 2a str. 2457T 1080637 NP_839571.1 CDS rpmJ NC_004741.1 4345587 4345703 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 4345587..4345703 Shigella flexneri 2a str. 2457T 1080638 NP_839572.1 CDS rpsM NC_004741.1 4345850 4346206 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 4345850..4346206 Shigella flexneri 2a str. 2457T 1080639 NP_839573.1 CDS rpsK NC_004741.1 4346223 4346612 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 4346223..4346612 Shigella flexneri 2a str. 2457T 1080640 NP_839574.2 CDS rpsD NC_004741.1 4346646 4347266 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 4346646..4347266 Shigella flexneri 2a str. 2457T 1080641 NP_839575.1 CDS rpoA NC_004741.1 4347292 4348281 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 4347292..4348281 Shigella flexneri 2a str. 2457T 1080642 NP_839576.1 CDS rplQ NC_004741.1 4348322 4348705 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 4348322..4348705 Shigella flexneri 2a str. 2457T 1080643 NP_839577.1 CDS S4437 NC_004741.1 4348875 4349549 D residues 1 to 224 of 224 are 100.00 pct identical to residues 1 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 4348875..4349549 Shigella flexneri 2a str. 2457T 1080644 NP_839578.1 CDS S4438 NC_004741.1 4349546 4349896 D residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAK18528.1|AF348706_217 (AF348706) IS orf [Shigella flexneri]; ISSfl3 orfB 4349546..4349896 Shigella flexneri 2a str. 2457T 1080645 NP_839579.1 CDS S4439 NC_004741.1 4349893 4350465 D residues 1 to 190 of 190 are 93.15 pct identical to residues 1 to 190 of 190 from GenPept : >gb|AAK18527.1|AF348706_216 (AF348706) IS orf [Shigella flexneri]; ISSfl3 orfC 4349893..4350465 Shigella flexneri 2a str. 2457T 1080646 NP_839580.1 CDS S4440 NC_004741.1 4350527 4351489 D residues 1 to 320 of 320 are 99.68 pct identical to residues 214 to 533 of 533 from GenPept : >gb|AAL72472.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfD 4350527..4351489 Shigella flexneri 2a str. 2457T 1080647 NP_839581.2 CDS S4441 NC_004741.1 4351813 4352178 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 4351813..4352178 Shigella flexneri 2a str. 2457T 1080648 NP_839582.2 CDS S4442 NC_004741.1 4352136 4353041 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4352136..4353041 Shigella flexneri 2a str. 2457T 1080649 NP_839583.2 CDS yjiI NC_004741.1 4353240 4353824 R in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown; RNA 2'-phosphotransferase-like protein complement(4353240..4353824) Shigella flexneri 2a str. 2457T 1080650 NP_839584.1 CDS yjiH NC_004741.1 4354062 4354757 D residues 1 to 231 of 231 are 99.13 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 : B4330; hypothetical protein 4354062..4354757 Shigella flexneri 2a str. 2457T 1080651 NP_839585.1 CDS yjiG NC_004741.1 4354754 4355215 D residues 1 to 153 of 153 are 99.34 pct identical to residues 1 to 153 of 153 from Escherichia coli K-12 : B4329; hypothetical protein 4354754..4355215 Shigella flexneri 2a str. 2457T 1080652 NP_839586.1 CDS iadA NC_004741.1 4355228 4356400 D residues 1 to 390 of 390 are 99.23 pct identical to residues 1 to 390 of 390 from Escherichia coli K-12 : B4328; isoaspartyl dipeptidase 4355228..4356400 Shigella flexneri 2a str. 2457T 1080653 NP_839587.1 CDS yjiE NC_004741.1 4356465 4357376 D residues 1 to 303 of 303 are 94.71 pct identical to residues 1 to 303 of 303 from Escherichia coli K-12 : B4327; DNA-binding transcriptional regulator 4356465..4357376 Shigella flexneri 2a str. 2457T 1080654 NP_839588.1 CDS yjiD NC_004741.1 4357369 4357770 R residues 1 to 133 of 133 are 99.24 pct identical to residues 1 to 133 of 133 from Escherichia coli K-12 : B4326; hypothetical protein complement(4357369..4357770) Shigella flexneri 2a str. 2457T 1080655 NP_839589.1 CDS S4449 NC_004741.1 4358047 4358550 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS1 orfB complement(4358047..4358550) Shigella flexneri 2a str. 2457T 1080656 NP_839590.1 CDS S4450 NC_004741.1 4358469 4358744 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(4358469..4358744) Shigella flexneri 2a str. 2457T 1080657 NP_839591.1 CDS uxuR NC_004741.1 4360182 4360955 R regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR complement(4360182..4360955) Shigella flexneri 2a str. 2457T 1080659 NP_839592.1 CDS uxuB NC_004741.1 4361170 4362630 R residues 1 to 486 of 486 are 98.76 pct identical to residues 1 to 486 of 486 from Escherichia coli K-12 : B4323; D-mannonate oxidoreductase complement(4361170..4362630) Shigella flexneri 2a str. 2457T 1080660 NP_839593.1 CDS uxuA NC_004741.1 4362711 4363895 R catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase complement(4362711..4363895) Shigella flexneri 2a str. 2457T 1080661 NP_839594.1 CDS gntP NC_004741.1 4364235 4365578 D residues 1 to 447 of 447 are 91.49 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 : B4321; fructuronate transporter 4364235..4365578 Shigella flexneri 2a str. 2457T 1080662 NP_839595.1 CDS fimH NC_004741.1 4365829 4366731 R residues 1 to 300 of 300 are 99.66 pct identical to residues 1 to 300 of 300 from Escherichia coli K-12 : B4320; minor fimbrial subunit, D-mannose specific adhesin complement(4365829..4366731) Shigella flexneri 2a str. 2457T 1080663 NP_839596.1 CDS fimG NC_004741.1 4366751 4367254 R residues 1 to 167 of 167 are 99.40 pct identical to residues 1 to 167 of 167 from Escherichia coli K-12 : B4319; minor fimbrial subunit, precursor polypeptide complement(4366751..4367254) Shigella flexneri 2a str. 2457T 1080664 NP_839597.1 CDS fimF NC_004741.1 4367267 4367797 R residues 1 to 176 of 176 are 97.72 pct identical to residues 1 to 176 of 176 from Escherichia coli K-12 : B4318; minor fimbrial subunit, precursor polypeptide complement(4367267..4367797) Shigella flexneri 2a str. 2457T 1080665 NP_839598.1 CDS S4460 NC_004741.1 4369871 4370374 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(4369871..4370374) Shigella flexneri 2a str. 2457T 1080667 NP_839599.1 CDS S4461 NC_004741.1 4370293 4370568 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(4370293..4370568) Shigella flexneri 2a str. 2457T 1080668 NP_839600.1 CDS fimC NC_004741.1 4371286 4372011 R residues 1 to 241 of 241 are 99.17 pct identical to residues 1 to 241 of 241 from Escherichia coli K-12 : B4316; required for type 1 fimbriae; periplasmic chaperone complement(4371286..4372011) Shigella flexneri 2a str. 2457T 1080669 NP_839601.1 CDS fimI NC_004741.1 4372048 4372686 R residues 1 to 212 of 212 are 98.11 pct identical to residues 4 to 215 of 215 from Escherichia coli K-12 : B4315; fimbrial protein complement(4372048..4372686) Shigella flexneri 2a str. 2457T 1080670 NP_839602.1 CDS fimA NC_004741.1 4372652 4373200 R residues 1 to 182 of 182 are 84.06 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 : B4314; major type 1 subunit fimbrin (pilin) complement(4372652..4373200) Shigella flexneri 2a str. 2457T 1080671 NP_839603.1 CDS fimE NC_004741.1 4373681 4374277 R inversion of on/off regulator of fimA; tyrosine recombinase complement(4373681..4374277) Shigella flexneri 2a str. 2457T 1080672 NP_839604.1 CDS fimB NC_004741.1 4374872 4375357 R residues 1 to 160 of 199 are 97.50 pct identical to residues 1 to 160 of 200 from Escherichia coli K-12 : B4312; involved in phase variation; recombinase; regulator for fimA complement(4374872..4375357) Shigella flexneri 2a str. 2457T 1080673 NP_839605.1 CDS yjhA NC_004741.1 4376979 4377527 D residues 1 to 182 of 182 are 100.00 pct identical to residues 60 to 241 of 241 from Escherichia coli K-12 : B4311; hypothetical protein 4376979..4377527 Shigella flexneri 2a str. 2457T 1080674 NP_839606.1 CDS yjhT NC_004741.1 4377439 4378653 D residues 1 to 404 of 404 are 98.76 pct identical to residues 1 to 404 of 404 from Escherichia coli K-12 : B4310; hypothetical protein 4377439..4378653 Shigella flexneri 2a str. 2457T 1080675 NP_839607.1 CDS yjhS NC_004741.1 4378940 4379698 D residues 1 to 252 of 252 are 99.60 pct identical to residues 75 to 326 of 326 from Escherichia coli K-12 : B4309; hypothetical protein 4378940..4379698 Shigella flexneri 2a str. 2457T 1080676 NP_839608.1 CDS S4471 NC_004741.1 4380167 4380670 R residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(4380167..4380670) Shigella flexneri 2a str. 2457T 1080677 NP_839609.1 CDS S4472 NC_004741.1 4380589 4380864 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(4380589..4380864) Shigella flexneri 2a str. 2457T 1080678 NP_839610.1 CDS S4473 NC_004741.1 4380959 4381654 D residues 1 to 231 of 231 are 81.46 pct identical to residues 30 to 261 of 261 from GenPept : >gb|AAL22652.1| (AE008876) regulatory protein, deoR family [Salmonella typhimurium LT2]; DeoR family transcriptional regulator 4380959..4381654 Shigella flexneri 2a str. 2457T 1080679 NP_839611.1 CDS S4474 NC_004741.1 4381755 4381871 R residues 4 to 38 of 38 are 88.57 pct identical to residues 29 to 63 of 96 from GenPept : >emb|CAC50649.1| (AX188968) unnamed protein product [Escherichia coli]; hypothetical protein complement(4381755..4381871) Shigella flexneri 2a str. 2457T 1080680 NP_839612.1 CDS S4475 NC_004741.1 4382130 4382408 D residues 1 to 92 of 92 are 92.39 pct identical to residues 3 to 94 of 94 from GenPept : >gb|AAG53987.1|AF327445_1 (AF327445) transposase A [Pantoea agglomerans]; ISEhe3a orf 4382130..4382408 Shigella flexneri 2a str. 2457T 1080681 NP_839613.1 CDS S4476 NC_004741.1 4382477 4382779 D residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 4382477..4382779 Shigella flexneri 2a str. 2457T 1080682 NP_839614.1 CDS S4477 NC_004741.1 4382920 4383633 D residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 4382920..4383633 Shigella flexneri 2a str. 2457T 1080683 NP_839615.1 CDS S4479 NC_004741.1 4384901 4385176 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4384901..4385176 Shigella flexneri 2a str. 2457T 1080685 NP_839616.1 CDS S4480 NC_004741.1 4385095 4385598 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4385095..4385598 Shigella flexneri 2a str. 2457T 1080686 NP_839617.1 CDS S4481 NC_004741.1 4385791 4386093 D residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 4385791..4386093 Shigella flexneri 2a str. 2457T 1080687 NP_839618.1 CDS S4483 NC_004741.1 4386333 4386959 D residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; IS911 orfB 4386333..4386959 Shigella flexneri 2a str. 2457T 1080688 NP_839619.1 CDS S4839 NC_004741.1 4386934 4388145 R residues 1 to 403 of 403 are 91.58 pct identical to residues 1 to 404 of 431 from NRprotein_Feb03 : >ref|NP_668085.1| prophage P4 integrase [Yersinia pestis KIM] gb|AAM84336.1|AE013677_1 prophage P4 integrase [Yersinia pestis KIM]; P4-type integrase complement(4386934..4388145) Shigella flexneri 2a str. 2457T 1080689 NP_839620.1 CDS yjgB NC_004741.1 4388582 4389643 D residues 1 to 353 of 353 are 94.05 pct identical to residues 1 to 353 of 353 from Escherichia coli K-12 : B4269; oxidoreductase 4388582..4389643 Shigella flexneri 2a str. 2457T 1080691 NP_839621.1 CDS yjgR NC_004741.1 4389772 4391286 D residues 1 to 500 of 504 are 94.59 pct identical to residues 1 to 500 of 500 from Escherichia coli K-12 : B4263; hypothetical protein 4389772..4391286 Shigella flexneri 2a str. 2457T 1080693 NP_839622.1 CDS yjgQ NC_004741.1 4391394 4392476 R residues 1 to 360 of 360 are 91.66 pct identical to residues 2 to 361 of 361 from Escherichia coli K-12 : B4262; hypothetical protein complement(4391394..4392476) Shigella flexneri 2a str. 2457T 1080694 NP_839623.1 CDS yjgP NC_004741.1 4392476 4393576 R residues 1 to 366 of 366 are 86.88 pct identical to residues 1 to 366 of 366 from Escherichia coli K-12 : B4261; hypothetical protein complement(4392476..4393576) Shigella flexneri 2a str. 2457T 1077860 NP_839624.1 CDS pepA NC_004741.1 4393843 4395354 D catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 4393843..4395354 Shigella flexneri 2a str. 2457T 1080695 NP_839625.1 CDS holC NC_004741.1 4395488 4395931 D binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 4395488..4395931 Shigella flexneri 2a str. 2457T 1080696 NP_839626.1 CDS valS NC_004741.1 4395931 4398786 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4395931..4398786 Shigella flexneri 2a str. 2457T 1080697 NP_839627.1 CDS yjgN NC_004741.1 4398840 4400036 R residues 1 to 389 of 389 are 87.91 pct identical to residues 5 to 393 of 393 from Escherichia coli K-12 : B4257; hypothetical protein complement(4398840..4400036) Shigella flexneri 2a str. 2457T 1080698 NP_839628.1 CDS yjgD NC_004741.1 4400775 4401191 R residues 1 to 119 of 138 are 84.03 pct identical to residues 1 to 119 of 138 from Escherichia coli K-12 : B4255; hypothetical protein complement(4400775..4401191) Shigella flexneri 2a str. 2457T 1080700 NP_839629.1 CDS argI NC_004741.1 4401353 4402366 D catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I 4401353..4402366 Shigella flexneri 2a str. 2457T 1080701 NP_839630.1 CDS S4497 NC_004741.1 4402438 4402713 D residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4402438..4402713 Shigella flexneri 2a str. 2457T 1080702 NP_839631.1 CDS S4498 NC_004741.1 4402632 4403135 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4402632..4403135 Shigella flexneri 2a str. 2457T 1080703 NP_839632.1 CDS yjgK NC_004741.1 4403997 4404449 R residues 1 to 150 of 150 are 100.00 pct identical to residues 4 to 153 of 153 from Escherichia coli K-12 : B4252; hypothetical protein complement(4403997..4404449) Shigella flexneri 2a str. 2457T 1080705 NP_839633.1 CDS yjgJ NC_004741.1 4404594 4404848 R residues 1 to 84 of 84 are 94.04 pct identical to residues 1 to 84 of 84 from Escherichia coli K-12 : B4251; hypothetical protein complement(4404594..4404848) Shigella flexneri 2a str. 2457T 1080706 NP_839634.1 CDS S4502 NC_004741.1 4404920 4405075 R residues 3 to 51 of 51 are 93.87 pct identical to residues 6 to 54 of 54 from Escherichia coli K-12 : B4250; hypothetical protein complement(4404920..4405075) Shigella flexneri 2a str. 2457T 1080707 NP_839635.1 CDS yjgI NC_004741.1 4405258 4405971 D residues 1 to 237 of 237 are 93.24 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B4249; oxidoreductase 4405258..4405971 Shigella flexneri 2a str. 2457T 1080708 NP_839636.1 CDS yjgH NC_004741.1 4406103 4406498 D residues 1 to 130 of 131 are 98.46 pct identical to residues 1 to 130 of 131 from Escherichia coli K-12 : B4248; hypothetical protein 4406103..4406498 Shigella flexneri 2a str. 2457T 1080709 NP_839637.1 CDS yjgG NC_004741.1 4406467 4406799 R residues 1 to 110 of 110 are 87.27 pct identical to residues 1 to 110 of 110 from Escherichia coli K-12 : B4247; hypothetical protein complement(4406467..4406799) Shigella flexneri 2a str. 2457T 1080710 NP_839638.1 CDS pyrL NC_004741.1 4406779 4406913 D residues 1 to 44 of 44 are 97.72 pct identical to residues 1 to 44 of 44 from Escherichia coli K-12 : B4246; pyrBI operon leader peptide 4406779..4406913 Shigella flexneri 2a str. 2457T 1080711 NP_839639.1 CDS pyrB NC_004741.1 4406917 4407852 D catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 4406917..4407852 Shigella flexneri 2a str. 2457T 1080712 NP_839640.1 CDS pyrI NC_004741.1 4407865 4408326 D involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase regulatory subunit 4407865..4408326 Shigella flexneri 2a str. 2457T 1080713 NP_839641.1 CDS yjgF NC_004741.1 4408360 4408785 D residues 1 to 141 of 141 are 100.00 pct identical to residues 1 to 141 of 141 from Escherichia coli K-12 : B4243; hypothetical protein 4408360..4408785 Shigella flexneri 2a str. 2457T 1080714 NP_839642.1 CDS mgtA NC_004741.1 4408991 4411687 R P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA complement(4408991..4411687) Shigella flexneri 2a str. 2457T 1080715 NP_839643.1 CDS treR NC_004741.1 4412066 4413013 D regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 4412066..4413013 Shigella flexneri 2a str. 2457T 1080716 NP_839644.1 CDS treB NC_004741.1 4413135 4414553 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; trehalose(maltose)-specific PTS system components IIBC 4413135..4414553 Shigella flexneri 2a str. 2457T 1080717 NP_839645.1 CDS treC NC_004741.1 4414603 4416258 D residues 1 to 551 of 551 are 99.45 pct identical to residues 1 to 551 of 551 from Escherichia coli K-12 : B4239; trehalose-6-phosphate hydrolase 4414603..4416258 Shigella flexneri 2a str. 2457T 1080718 NP_839646.1 CDS nrdD NC_004741.1 4416652 4418790 D Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 4416652..4418790 Shigella flexneri 2a str. 2457T 1080719 NP_839647.1 CDS nrdG NC_004741.1 4418948 4419412 D activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 4418948..4419412 Shigella flexneri 2a str. 2457T 1080720 NP_839648.1 CDS pmbA NC_004741.1 4420022 4421374 R protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA complement(4420022..4421374) Shigella flexneri 2a str. 2457T 1080722 NP_839649.1 CDS yjgA NC_004741.1 4421468 4422019 D residues 1 to 183 of 183 are 93.44 pct identical to residues 1 to 183 of 183 from Escherichia coli K-12 : B4234; hypothetical protein 4421468..4422019 Shigella flexneri 2a str. 2457T 1080723 NP_839650.1 CDS yjfG NC_004741.1 4422102 4423475 R residues 1 to 457 of 457 are 99.78 pct identical to residues 1 to 457 of 457 from Escherichia coli K-12 : B4233; ligase complement(4422102..4423475) Shigella flexneri 2a str. 2457T 1080724 NP_839651.1 CDS fbp NC_004741.1 4423651 4424649 D catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 4423651..4424649 Shigella flexneri 2a str. 2457T 1080725 NP_839652.1 CDS S4521 NC_004741.1 4424687 4426015 R residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf complement(4424687..4426015) Shigella flexneri 2a str. 2457T 1080728 NP_839653.1 CDS ytfT NC_004741.1 4427102 4428127 R residues 1 to 341 of 341 are 71.84 pct identical to residues 1 to 341 of 341 from Escherichia coli K-12 : B4230; transport system permease complement(4427102..4428127) Shigella flexneri 2a str. 2457T 1080730 NP_839654.1 CDS ytfR NC_004741.1 4428138 4429640 R residues 1 to 381 of 500 are 95.80 pct identical to residues 1 to 381 of 417 from Escherichia coli K-12 : B4228; ATP-binding component of a transport system complement(4428138..4429640) Shigella flexneri 2a str. 2457T 1080733 NP_839655.1 CDS ppa NC_004741.1 4431046 4431576 D catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 4431046..4431576 Shigella flexneri 2a str. 2457T 1080735 NP_839656.1 CDS yjfA NC_004741.1 4431952 4432215 D residues 1 to 87 of 87 are 96.55 pct identical to residues 3 to 89 of 89 from Escherichia coli K-12 : B4223; hypothetical protein 4431952..4432215 Shigella flexneri 2a str. 2457T 1080736 NP_839657.1 CDS ytfP NC_004741.1 4431956 4432297 R residues 1 to 113 of 113 are 100.00 pct identical to residues 1 to 113 of 113 from Escherichia coli K-12 : B4222; hypothetical protein complement(4431956..4432297) Shigella flexneri 2a str. 2457T 1080737 NP_839658.1 CDS ytfN NC_004741.1 4432300 4436079 R residues 1 to 1259 of 1259 are 94.91 pct identical to residues 1 to 1259 of 1259 from Escherichia coli K-12 : B4221; hypothetical protein complement(4432300..4436079) Shigella flexneri 2a str. 2457T 1080738 NP_839659.1 CDS ytfM NC_004741.1 4436076 4437809 R residues 1 to 577 of 577 are 96.88 pct identical to residues 1 to 577 of 577 from Escherichia coli K-12 : B4220; hypothetical protein complement(4436076..4437809) Shigella flexneri 2a str. 2457T 1080739 NP_839660.1 CDS msrA NC_004741.1 4438015 4438653 D this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 4438015..4438653 Shigella flexneri 2a str. 2457T 1080740 NP_839661.1 CDS ytfL NC_004741.1 4438976 4440319 D residues 1 to 447 of 447 are 97.09 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 : B4218; transporter 4438976..4440319 Shigella flexneri 2a str. 2457T 1080741 NP_839662.1 CDS ytfK NC_004741.1 4440381 4440626 R residues 1 to 81 of 81 are 98.37 pct identical to residues 1 to 81 of 81 from Escherichia coli K-12 : B4217; hypothetical protein complement(4440381..4440626) Shigella flexneri 2a str. 2457T 1080742 NP_839663.1 CDS ytfJ NC_004741.1 4440912 4441466 D residues 1 to 184 of 184 are 98.36 pct identical to residues 1 to 184 of 184 from Escherichia coli K-12 : B4216; hypothetical protein 4440912..4441466 Shigella flexneri 2a str. 2457T 1077112 NP_839664.1 CDS cysQ NC_004741.1 4442679 4443419 R catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase complement(4442679..4443419) Shigella flexneri 2a str. 2457T 1080744 NP_839665.1 CDS cpdB NC_004741.1 4443609 4445552 D periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein 4443609..4445552 Shigella flexneri 2a str. 2457T 1080745 NP_839666.1 CDS ytfH NC_004741.1 4445678 4446148 R residues 1 to 156 of 156 are 100.00 pct identical to residues 1 to 156 of 156 from Escherichia coli K-12 : B4212; hypothetical protein complement(4445678..4446148) Shigella flexneri 2a str. 2457T 1080749 NP_839667.1 CDS ytfG NC_004741.1 4446147 4447007 D residues 1 to 286 of 286 are 93.70 pct identical to residues 1 to 286 of 286 from Escherichia coli K-12 : B4211; oxidoreductase 4446147..4447007 Shigella flexneri 2a str. 2457T 1077990 NP_839668.1 CDS ytfF NC_004741.1 4447116 4448081 D residues 1 to 321 of 321 are 95.01 pct identical to residues 4 to 324 of 324 from Escherichia coli K-12 : B4210; transmembrane subunit 4447116..4448081 Shigella flexneri 2a str. 2457T 1080750 NP_839669.1 CDS ytfE NC_004741.1 4448189 4448851 D Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 4448189..4448851 Shigella flexneri 2a str. 2457T 1080751 NP_839670.1 CDS cycA NC_004741.1 4448896 4450308 R involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease complement(4448896..4450308) Shigella flexneri 2a str. 2457T 1080753 NP_839671.1 CDS ytfB NC_004741.1 4451419 4452000 D residues 1 to 193 of 193 are 68.75 pct identical to residues 1 to 224 of 224 from Escherichia coli K-12 : B4206; hypothetical protein 4451419..4452000 Shigella flexneri 2a str. 2457T 1080754 NP_839672.1 CDS ytfA NC_004741.1 4451984 4452310 R residues 1 to 108 of 108 are 98.14 pct identical to residues 1 to 108 of 108 from Escherichia coli K-12 : B4205; hypothetical protein complement(4451984..4452310) Shigella flexneri 2a str. 2457T 1079030 NP_839673.1 CDS fabG NC_004741.1 4452843 4453634 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 4452843..4453634 Shigella flexneri 2a str. 2457T 1080755 NP_839674.1 CDS S4548 NC_004741.1 4453644 4454528 D residues 1 to 294 of 294 are 99.65 pct identical to residues 1 to 294 of 294 from GenPept : >gb|AAL50626.1|AF417476_3 (AF417476) unknown [Shigella flexneri]; hypothetical protein 4453644..4454528 Shigella flexneri 2a str. 2457T 1077714 NP_839675.1 CDS S4549 NC_004741.1 4454463 4454966 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB complement(4454463..4454966) Shigella flexneri 2a str. 2457T 1080756 NP_839676.1 CDS S4550 NC_004741.1 4454885 4455160 R residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(4454885..4455160) Shigella flexneri 2a str. 2457T 1080757 NP_839677.1 CDS S4551 NC_004741.1 4455218 4456036 D residues 1 to 272 of 272 are 91.54 pct identical to residues 1 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 4455218..4456036 Shigella flexneri 2a str. 2457T 1080758 NP_839678.1 CDS S4552 NC_004741.1 4456077 4457129 R residues 1 to 350 of 350 are 94.85 pct identical to residues 1 to 350 of 444 from Escherichia coli K-12 : B4132; transport of lysine/cadaverine complement(4456077..4457129) Shigella flexneri 2a str. 2457T 1080759 NP_839679.1 CDS S4553 NC_004741.1 4457304 4457579 D residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4457304..4457579 Shigella flexneri 2a str. 2457T 1080760 NP_839680.1 CDS S4554 NC_004741.1 4457498 4458001 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4457498..4458001 Shigella flexneri 2a str. 2457T 1080761 NP_839681.1 CDS yjdC NC_004741.1 4458546 4459121 R residues 1 to 191 of 191 are 99.47 pct identical to residues 9 to 199 of 199 from Escherichia coli K-12 : B4135; transcriptional regulator complement(4458546..4459121) Shigella flexneri 2a str. 2457T 1080763 NP_839682.1 CDS dipZ NC_004741.1 4459158 4460855 R two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein precursor complement(4459158..4460855) Shigella flexneri 2a str. 2457T 1080764 NP_839683.1 CDS cutA NC_004741.1 4460831 4461169 R copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA complement(4460831..4461169) Shigella flexneri 2a str. 2457T 1080765 NP_839684.1 CDS dcuA NC_004741.1 4461285 4462586 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(4461285..4462586) Shigella flexneri 2a str. 2457T 1080766 NP_839685.1 CDS aspA NC_004741.1 4462704 4464185 R catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(4462704..4464185) Shigella flexneri 2a str. 2457T 1080767 NP_839686.2 CDS fxsA NC_004741.1 4464477 4464953 D F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA 4464477..4464953 Shigella flexneri 2a str. 2457T 1080768 NP_839687.1 CDS yjeH NC_004741.1 4464969 4466225 R uncharacterized member of the APC superfamily of amino acid transporters; unknown function; inner membrane protein YjeH complement(4464969..4466225) Shigella flexneri 2a str. 2457T 1080769 NP_839688.1 CDS groES NC_004741.1 4466501 4466794 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4466501..4466794 Shigella flexneri 2a str. 2457T 1080771 NP_839689.1 CDS groEL NC_004741.1 4466838 4468484 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 4466838..4468484 Shigella flexneri 2a str. 2457T 1080772 NP_839690.1 CDS yjeI NC_004741.1 4468589 4468975 D residues 1 to 128 of 128 are 100.00 pct identical to residues 1 to 128 of 128 from Escherichia coli K-12 : B4144; hypothetical protein 4468589..4468975 Shigella flexneri 2a str. 2457T 1080773 NP_839691.1 CDS yjeJ NC_004741.1 4469178 4470047 R residues 1 to 289 of 289 are 99.65 pct identical to residues 1 to 289 of 289 from Escherichia coli K-12 : B4145; hypothetical protein complement(4469178..4470047) Shigella flexneri 2a str. 2457T 1080774 NP_839692.1 CDS S4567 NC_004741.1 4470233 4470508 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4470233..4470508 Shigella flexneri 2a str. 2457T 1080775 NP_839693.1 CDS S4568 NC_004741.1 4470427 4470930 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4470427..4470930 Shigella flexneri 2a str. 2457T 1080776 NP_839694.1 CDS yjeK NC_004741.1 4471209 4472237 R residues 1 to 342 of 342 are 98.24 pct identical to residues 1 to 342 of 342 from Escherichia coli K-12 : B4146; hypothetical protein complement(4471209..4472237) Shigella flexneri 2a str. 2457T 1080777 NP_839695.1 CDS efp NC_004741.1 4472279 4472845 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4472279..4472845 Shigella flexneri 2a str. 2457T 1080778 NP_839696.1 CDS sugE NC_004741.1 4473305 4473772 D residues 1 to 155 of 155 are 87.09 pct identical to residues 1 to 155 of 155 from Escherichia coli K-12 : B4148; may be a chaperone; suppresser of groEL 4473305..4473772 Shigella flexneri 2a str. 2457T 1080779 NP_839697.1 CDS blc NC_004741.1 4473769 4474302 R lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc complement(4473769..4474302) Shigella flexneri 2a str. 2457T 1077869 NP_839698.1 CDS ampC NC_004741.1 4474391 4475524 R residues 1 to 377 of 377 are 98.14 pct identical to residues 1 to 377 of 377 from Escherichia coli K-12 : B4150; involved in penicillin resistance; beta-lactamase complement(4474391..4475524) Shigella flexneri 2a str. 2457T 1080780 NP_839699.1 CDS frdD NC_004741.1 4475587 4475946 R in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D complement(4475587..4475946) Shigella flexneri 2a str. 2457T 1080781 NP_839700.1 CDS frdC NC_004741.1 4475957 4476352 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C complement(4475957..4476352) Shigella flexneri 2a str. 2457T 1080782 NP_839701.1 CDS frdB NC_004741.1 4476363 4477097 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit complement(4476363..4477097) Shigella flexneri 2a str. 2457T 1080783 NP_839702.1 CDS frdA NC_004741.1 4477090 4478898 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit complement(4477090..4478898) Shigella flexneri 2a str. 2457T 1080784 NP_839703.1 CDS yjeA NC_004741.1 4479223 4480200 D lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4479223..4480200 Shigella flexneri 2a str. 2457T 1080785 NP_839704.1 CDS S4579 NC_004741.1 4480989 4481264 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(4480989..4481264) Shigella flexneri 2a str. 2457T 1080786 NP_839705.1 CDS yjeP NC_004741.1 4482805 4486116 R residues 1 to 1103 of 1103 are 95.39 pct identical to residues 1 to 1107 of 1107 from Escherichia coli K-12 : B4159; hypothetical protein complement(4482805..4486116) Shigella flexneri 2a str. 2457T 1080788 NP_839706.1 CDS psd NC_004741.1 4486138 4487106 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(4486138..4487106) Shigella flexneri 2a str. 2457T 1080976 NP_839707.2 CDS yjeQ NC_004741.1 4487203 4488255 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(4487203..4488255) Shigella flexneri 2a str. 2457T 1080789 NP_839708.2 CDS yjeR NC_004741.1 4488350 4488895 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4488350..4488895 Shigella flexneri 2a str. 2457T 1080906 NP_839709.1 CDS yjeS NC_004741.1 4489906 4491045 R residues 1 to 379 of 379 are 99.47 pct identical to residues 1 to 379 of 379 from Escherichia coli K-12 : B4166; hypothetical protein complement(4489906..4491045) Shigella flexneri 2a str. 2457T 1080795 NP_839710.1 CDS yjeF NC_004741.1 4491044 4492591 D residues 1 to 515 of 515 are 92.42 pct identical to residues 1 to 515 of 515 from Escherichia coli K-12 : B4167; hypothetical protein 4491044..4492591 Shigella flexneri 2a str. 2457T 1077769 NP_839711.1 CDS yjeE NC_004741.1 4492563 4493024 D possibly involved in cell wall synthesis; ATPase 4492563..4493024 Shigella flexneri 2a str. 2457T 1080796 NP_839712.1 CDS amiB NC_004741.1 4493043 4494380 D residues 1 to 445 of 445 are 93.48 pct identical to residues 1 to 445 of 445 from Escherichia coli K-12 : B4169; N-acetylmuramoyl-l-alanine amidase II 4493043..4494380 Shigella flexneri 2a str. 2457T 1080911 NP_839713.1 CDS mutL NC_004741.1 4494390 4496237 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4494390..4496237 Shigella flexneri 2a str. 2457T 1080798 NP_839714.1 CDS miaA NC_004741.1 4496230 4497180 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4496230..4497180 Shigella flexneri 2a str. 2457T 1079793 NP_839715.1 CDS hfq NC_004741.1 4497266 4497574 D Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4497266..4497574 Shigella flexneri 2a str. 2457T 1080960 NP_839716.1 CDS hflX NC_004741.1 4497650 4498930 D involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 4497650..4498930 Shigella flexneri 2a str. 2457T 1080799 NP_839717.1 CDS hflK NC_004741.1 4499016 4500275 D with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4499016..4500275 Shigella flexneri 2a str. 2457T 1080800 NP_839718.1 CDS hflC NC_004741.1 4500278 4501282 D with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4500278..4501282 Shigella flexneri 2a str. 2457T 1080801 NP_839719.1 CDS yjeT NC_004741.1 4501364 4501561 D residues 1 to 65 of 65 are 63.07 pct identical to residues 1 to 65 of 65 from Escherichia coli K-12 : B4176; hypothetical protein 4501364..4501561 Shigella flexneri 2a str. 2457T 1078110 NP_839720.1 CDS purA NC_004741.1 4501665 4502963 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4501665..4502963 Shigella flexneri 2a str. 2457T 1080802 NP_839721.1 CDS yjeB NC_004741.1 4503168 4503593 D negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4503168..4503593 Shigella flexneri 2a str. 2457T 1080926 NP_839722.2 CDS vacB NC_004741.1 4503632 4506073 D 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4503632..4506073 Shigella flexneri 2a str. 2457T 1080803 NP_839723.1 CDS yjfH NC_004741.1 4506253 4506984 D Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4506253..4506984 Shigella flexneri 2a str. 2457T 1080804 NP_839724.1 CDS S4604 NC_004741.1 4507085 4507360 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4507085..4507360 Shigella flexneri 2a str. 2457T 1080806 NP_839725.1 CDS S4605 NC_004741.1 4507279 4507782 D residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4507279..4507782 Shigella flexneri 2a str. 2457T 1080807 NP_839726.1 CDS yjfM NC_004741.1 4508048 4508686 D residues 1 to 212 of 212 are 74.05 pct identical to residues 1 to 212 of 212 from Escherichia coli K-12 : B4185; hypothetical protein 4508048..4508686 Shigella flexneri 2a str. 2457T 1080809 NP_839727.1 CDS yjfC NC_004741.1 4508689 4509852 D residues 1 to 387 of 387 are 94.83 pct identical to residues 1 to 387 of 387 from Escherichia coli K-12 : B4186; synthetase/amidase 4508689..4509852 Shigella flexneri 2a str. 2457T 1080810 NP_839728.1 CDS S4610 NC_004741.1 4511235 4511738 R residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB complement(4511235..4511738) Shigella flexneri 2a str. 2457T 1080812 NP_839729.1 CDS S4611 NC_004741.1 4511657 4511932 R residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA complement(4511657..4511932) Shigella flexneri 2a str. 2457T 1080792 NP_839730.1 CDS yjfN NC_004741.1 4512455 4512757 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from Escherichia coli K-12 : B4188; hypothetical protein complement(4512455..4512757) Shigella flexneri 2a str. 2457T 1080813 NP_839731.2 CDS yjfO NC_004741.1 4512879 4513208 R residues 1 to 142 of 142 are 87.32 pct identical to residues 1 to 142 of 142 from Escherichia coli K-12 : B4189; hypothetical protein complement(4512879..4513208) Shigella flexneri 2a str. 2457T 1080814 NP_839732.1 CDS yjfP NC_004741.1 4513390 4514139 D YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4513390..4514139 Shigella flexneri 2a str. 2457T 1080815 NP_839733.1 CDS yjfQ NC_004741.1 4514136 4514891 R negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR complement(4514136..4514891) Shigella flexneri 2a str. 2457T 1080816 NP_839734.1 CDS yjfR NC_004741.1 4514999 4516069 R residues 1 to 356 of 356 are 96.34 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 : B4192; L-ascorbate 6-phosphate lactonase complement(4514999..4516069) Shigella flexneri 2a str. 2457T 1080817 NP_839735.2 CDS ulaA NC_004741.1 4516418 4517815 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; ascorbate-specific PTS system enzyme IIC 4516418..4517815 Shigella flexneri 2a str. 2457T 1080818 NP_839736.1 CDS sgaB NC_004741.1 4517831 4518136 D residues 1 to 101 of 101 are 99.00 pct identical to residues 1 to 101 of 101 from Escherichia coli K-12 : B4194; L-ascorbate-specific enzyme IIB component of PTS 4517831..4518136 Shigella flexneri 2a str. 2457T 1080819 NP_839737.1 CDS ptxA NC_004741.1 4518146 4518610 D residues 1 to 154 of 154 are 95.45 pct identical to residues 1 to 154 of 154 from Escherichia coli K-12 : B4195; L-ascorbate-specific enzyme IIA component of PTS 4518146..4518610 Shigella flexneri 2a str. 2457T 1080820 NP_839738.1 CDS ulaD NC_004741.1 4518624 4519274 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4518624..4519274 Shigella flexneri 2a str. 2457T 1080821 NP_839739.1 CDS sgaU NC_004741.1 4519284 4520138 D UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4519284..4520138 Shigella flexneri 2a str. 2457T 1080822 NP_839740.1 CDS sgaE NC_004741.1 4520138 4520824 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4520138..4520824 Shigella flexneri 2a str. 2457T 1080823 NP_839741.1 CDS yjfY NC_004741.1 4520953 4521228 R residues 1 to 91 of 91 are 89.01 pct identical to residues 1 to 91 of 91 from Escherichia coli K-12 : B4199; hypothetical protein complement(4520953..4521228) Shigella flexneri 2a str. 2457T 1080824 NP_839742.1 CDS rpsF NC_004741.1 4521555 4521950 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4521555..4521950 Shigella flexneri 2a str. 2457T 1080825 NP_839743.1 CDS priB NC_004741.1 4521957 4522271 D binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4521957..4522271 Shigella flexneri 2a str. 2457T 1080826 NP_839744.1 CDS rpsR NC_004741.1 4522276 4522503 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4522276..4522503 Shigella flexneri 2a str. 2457T 1077861 NP_839745.1 CDS rplI NC_004741.1 4522545 4522994 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4522545..4522994 Shigella flexneri 2a str. 2457T 1080827 NP_839746.1 CDS S4629 NC_004741.1 4523692 4523970 D residues 1 to 92 of 92 are 92.39 pct identical to residues 3 to 94 of 94 from GenPept : >gb|AAG53987.1|AF327445_1 (AF327445) transposase A [Pantoea agglomerans]; ISEhe3 orfA 4523692..4523970 Shigella flexneri 2a str. 2457T 1080828 NP_839747.1 CDS S4630 NC_004741.1 4524027 4524608 D residues 1 to 193 of 193 are 95.85 pct identical to residues 10 to 202 of 279 from GenPept : >gb|AAG53988.1|AF327445_2 (AF327445) transposase B [Pantoea agglomerans]; ISEhe3 orfB 4524027..4524608 Shigella flexneri 2a str. 2457T 1080829 NP_839748.1 CDS S4631 NC_004741.1 4524649 4525362 R residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB complement(4524649..4525362) Shigella flexneri 2a str. 2457T 1080830 NP_839749.1 CDS S4632 NC_004741.1 4525503 4525805 R residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA complement(4525503..4525805) Shigella flexneri 2a str. 2457T 1080831 NP_839750.1 CDS S4633 NC_004741.1 4525870 4526190 D residues 1 to 106 of 106 are 98.11 pct identical to residues 282 to 387 of 387 from GenPept : >gb|AAG59527.1|AE005665_9 (AE005665) orf; conserved hypothetical protein [Escherichia coli O157:H7 EDL933]; hypothetical protein 4525870..4526190 Shigella flexneri 2a str. 2457T 1080832 NP_839751.1 CDS S4635 NC_004741.1 4526799 4528454 R residues 1 to 551 of 551 are 51.70 pct identical to residues 1 to 584 of 584 from GenPept : >gb|AAG59529.1|AE005666_1 (AE005666) restriction modification enzyme S subunit [Escherichia coli O157:H7 EDL933]; hypothetical protein complement(4526799..4528454) Shigella flexneri 2a str. 2457T 1080834 NP_839752.1 CDS S4638 NC_004741.1 4532719 4532994 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4532719..4532994 Shigella flexneri 2a str. 2457T 1080837 NP_839753.1 CDS S4639 NC_004741.1 4532913 4533416 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4532913..4533416 Shigella flexneri 2a str. 2457T 1080838 NP_839754.1 CDS yjiA NC_004741.1 4534262 4535116 R residues 1 to 284 of 284 are 93.66 pct identical to residues 1 to 284 of 284 from Escherichia coli K-12 : B4352; GTP-binding protein YjiA complement(4534262..4535116) Shigella flexneri 2a str. 2457T 1080839 NP_839755.1 CDS yjiX NC_004741.1 4535229 4535432 R residues 1 to 67 of 67 are 100.00 pct identical to residues 1 to 67 of 67 from Escherichia coli K-12 : B4353; hypothetical protein complement(4535229..4535432) Shigella flexneri 2a str. 2457T 1080840 NP_839756.1 CDS yjiY NC_004741.1 4535482 4537647 R residues 1 to 721 of 721 are 87.65 pct identical to residues 1 to 721 of 721 from Escherichia coli K-12 : B4354; carbon starvation protein complement(4535482..4537647) Shigella flexneri 2a str. 2457T 1080841 NP_839757.1 CDS hpaC NC_004741.1 4538025 4538537 R residues 1 to 170 of 170 are 99.41 pct identical to residues 1 to 170 of 170 from GenPept : >emb|CAA86049.2| (Z37980) component C of the 4HPA-hydroxylase [Escherichia coli]; component C of the 4HPA-hydroxylase complement(4538025..4538537) Shigella flexneri 2a str. 2457T 1080842 NP_839758.1 CDS S4646 NC_004741.1 4540366 4541133 R residues 2 to 243 of 255 are 83.47 pct identical to residues 53 to 294 of 312 from GenPept : >emb|CAD08235.1| (AL627269) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein complement(4540366..4541133) Shigella flexneri 2a str. 2457T 1080844 NP_839759.1 CDS hpaA NC_004741.1 4541304 4542194 R residues 13 to 296 of 296 are 59.85 pct identical to residues 8 to 291 of 298 from GenPept : >gb|AAL20040.1| (AE008748) 4-hydroxyphenylacetate catabolism [Salmonella typhimurium LT2]; 4-hydroxyphenylacetate 3-monooxygenase operon regulatory protein complement(4541304..4542194) Shigella flexneri 2a str. 2457T 1080845 NP_839760.1 CDS hpaX NC_004741.1 4542204 4543559 R residues 17 to 434 of 451 are 66.58 pct identical to residues 25 to 446 of 455 from GenPept : >emb|CAC90586.1| (AJ414150) 4-hydroxyphenylacetate permease [Yersinia pestis]; 4-hydroxyphenylacetate permease complement(4542204..4543559) Shigella flexneri 2a str. 2457T 1079519 NP_839761.1 CDS hpaI NC_004741.1 4543581 4544384 R residues 1 to 251 of 267 are 94.02 pct identical to residues 1 to 251 of 262 from GenPept : >emb|CAA86045.1| (Z37980) hypothetical 2,4-dihydroxy-hepta-2-ene-1,7-dioate aldolase [Escherichia coli]; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase complement(4543581..4544384) Shigella flexneri 2a str. 2457T 1080846 NP_839762.1 CDS hpaH NC_004741.1 4544395 4545198 R residues 1 to 267 of 267 are 98.87 pct identical to residues 1 to 267 of 267 from GenPept : >emb|CAA86044.1| (Z37980) 2-oxo-hept-3-ene-1,7-dioate hydratase [Escherichia coli]; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase complement(4544395..4545198) Shigella flexneri 2a str. 2457T 1080847 NP_839763.1 CDS hpaF NC_004741.1 4545266 4545646 R residues 1 to 126 of 126 are 88.09 pct identical to residues 1 to 126 of 126 from GenPept : >emb|CAD08230.1| (AL627269) 5-carboxymethyl-2-hydroxymuconate delta-isomerase [Salmonella enterica subsp. enterica serovar Typhi]; 5-carboxymethyl-2-hydroxymuconate delta-isomerase complement(4545266..4545646) Shigella flexneri 2a str. 2457T 1080848 NP_839764.1 CDS hpaD NC_004741.1 4545656 4546507 R residues 1 to 283 of 283 are 99.64 pct identical to residues 1 to 283 of 283 from GenPept : >emb|CAA86042.1| (Z37980) homoprotocatechuate dyoxygenase [Escherichia coli]; homoprotocatechuate dyoxygenase complement(4545656..4546507) Shigella flexneri 2a str. 2457T 1080849 NP_839765.1 CDS hpaE NC_004741.1 4546509 4547975 R residues 1 to 488 of 488 are 99.18 pct identical to residues 1 to 488 of 488 from GenPept : >emb|CAA86041.1| (Z37980) 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase [Escherichia coli]; 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase complement(4546509..4547975) Shigella flexneri 2a str. 2457T 1080850 NP_839766.1 CDS hpaG NC_004741.1 4547972 4549261 R residues 1 to 429 of 429 are 95.80 pct identical to residues 1 to 429 of 429 from GenPept : >emb|CAA86040.1| (Z37980) 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxilase/isomer [Escherichia coli]; 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxilase/isomerase complement(4547972..4549261) Shigella flexneri 2a str. 2457T 1080852 NP_839767.1 CDS hpcR NC_004741.1 4549533 4549979 D residues 1 to 148 of 148 are 100.00 pct identical to residues 1 to 148 of 148 from GenPept : >emb|CAA86039.1| (Z37980) regulator of the meta operon of 3,4dhpa metabolic pathway [Escherichia coli]; regulator of the 4HPA-hydroxylase operon 4549533..4549979 Shigella flexneri 2a str. 2457T 1080853 NP_839768.1 CDS tsr NC_004741.1 4550098 4551762 D residues 1 to 554 of 554 are 88.08 pct identical to residues 1 to 551 of 551 from Escherichia coli K-12 : B4355; methyl-accepting chemotaxis protein I, serine sensor receptor 4550098..4551762 Shigella flexneri 2a str. 2457T 1080854 NP_839769.1 CDS yjiZ NC_004741.1 4551811 4553172 R residues 1 to 453 of 453 are 98.89 pct identical to residues 1 to 453 of 453 from Escherichia coli K-12 : B4356; joins former yjiZ and yjjL; transporter complement(4551811..4553172) Shigella flexneri 2a str. 2457T 1080855 NP_839770.1 CDS yjjM NC_004741.1 4553387 4554193 R residues 1 to 268 of 268 are 98.50 pct identical to residues 1 to 268 of 268 from Escherichia coli K-12 : B4357; hypothetical protein complement(4553387..4554193) Shigella flexneri 2a str. 2457T 1080856 NP_839771.2 CDS mdoB NC_004741.1 4555600 4557891 R catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I complement(4555600..4557891) Shigella flexneri 2a str. 2457T 1080858 NP_839772.1 CDS yjjA NC_004741.1 4558145 4558642 R residues 1 to 165 of 165 are 91.51 pct identical to residues 1 to 165 of 165 from Escherichia coli K-12 : B4360; hypothetical protein complement(4558145..4558642) Shigella flexneri 2a str. 2457T 1080859 NP_839773.1 CDS dnaC NC_004741.1 4558688 4559425 R acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC complement(4558688..4559425) Shigella flexneri 2a str. 2457T 1080860 NP_839774.1 CDS dnaT NC_004741.1 4559428 4559967 R This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI complement(4559428..4559967) Shigella flexneri 2a str. 2457T 1080861 NP_839775.2 CDS yjjB NC_004741.1 4560074 4560547 R residues 1 to 108 of 108 are 99.07 pct identical to residues 1 to 108 of 108 from Escherichia coli K-12 : B4363; hypothetical protein complement(4560074..4560547) Shigella flexneri 2a str. 2457T 1080862 NP_839776.1 CDS S4666 NC_004741.1 4561932 4562207 D residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4561932..4562207 Shigella flexneri 2a str. 2457T 1077773 NP_839777.1 CDS S4667 NC_004741.1 4562126 4562629 D residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 4562126..4562629 Shigella flexneri 2a str. 2457T 1080864 NP_839778.2 CDS bglJ NC_004741.1 4563227 4563850 D regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 4563227..4563850 Shigella flexneri 2a str. 2457T 1080866 NP_839779.1 CDS fhuF NC_004741.1 4563888 4564676 R residues 1 to 262 of 262 are 97.32 pct identical to residues 1 to 262 of 262 from Escherichia coli K-12 : B4367; ferric iron reductase involved in ferric hydroximate transport complement(4563888..4564676) Shigella flexneri 2a str. 2457T 1080867 NP_839780.1 CDS rsmC NC_004741.1 4565691 4566722 R 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase complement(4565691..4566722) Shigella flexneri 2a str. 2457T 1080871 NP_839781.1 CDS holD NC_004741.1 4566825 4567238 D with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 4566825..4567238 Shigella flexneri 2a str. 2457T 1080873 NP_839782.1 CDS rimI NC_004741.1 4567207 4567653 D alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 4567207..4567653 Shigella flexneri 2a str. 2457T 1080874 NP_839783.1 CDS yjjG NC_004741.1 4567668 4568345 D manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 4567668..4568345 Shigella flexneri 2a str. 2457T 1080875 NP_839784.1 CDS prfC NC_004741.1 4568436 4570025 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 4568436..4570025 Shigella flexneri 2a str. 2457T 1080876 NP_839785.1 CDS osmY NC_004741.1 4570418 4571023 D residues 1 to 201 of 201 are 99.50 pct identical to residues 1 to 201 of 201 from Escherichia coli K-12 : B4376; periplasmic protein 4570418..4571023 Shigella flexneri 2a str. 2457T 1080877 NP_839786.1 CDS yjjU NC_004741.1 4571423 4572496 D residues 1 to 357 of 357 are 99.71 pct identical to residues 1 to 357 of 357 from Escherichia coli K-12 : B4377; hypothetical protein 4571423..4572496 Shigella flexneri 2a str. 2457T 1080878 NP_839787.1 CDS yjjV NC_004741.1 4572637 4573275 D residues 1 to 210 of 212 are 95.71 pct identical to residues 1 to 210 of 211 from Escherichia coli K-12 : B4378; hypothetical protein 4572637..4573275 Shigella flexneri 2a str. 2457T 1080879 NP_839788.1 CDS yjjW NC_004741.1 4573489 4574352 R residues 1 to 287 of 287 are 99.30 pct identical to residues 1 to 287 of 287 from Escherichia coli K-12 : B4379; activating enzyme complement(4573489..4574352) Shigella flexneri 2a str. 2457T 1080880 NP_839789.1 CDS yjjI NC_004741.1 4574324 4575865 R residues 1 to 513 of 513 are 99.22 pct identical to residues 1 to 516 of 516 from Escherichia coli K-12 : B4380; hypothetical protein complement(4574324..4575865) Shigella flexneri 2a str. 2457T 1080881 NP_839790.1 CDS deoC NC_004741.1 4576123 4576902 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 4576123..4576902 Shigella flexneri 2a str. 2457T 1080882 NP_839791.1 CDS deoA NC_004741.1 4577029 4578351 D Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 4577029..4578351 Shigella flexneri 2a str. 2457T 1080883 NP_839792.1 CDS deoB NC_004741.1 4578404 4579627 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 4578404..4579627 Shigella flexneri 2a str. 2457T 1080884 NP_839793.1 CDS deoD NC_004741.1 4579684 4580403 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 4579684..4580403 Shigella flexneri 2a str. 2457T 1080885 NP_839794.1 CDS S4688 NC_004741.1 4580564 4580827 R residues 1 to 87 of 87 are 100.00 pct identical to residues 1 to 87 of 87 from GenPept : >gb|AAG59566.1|AE005669_10 (AE005669) Z5987 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein complement(4580564..4580827) Shigella flexneri 2a str. 2457T 1080886 NP_839795.1 CDS smp NC_004741.1 4581902 4582546 R residues 1 to 200 of 214 are 95.49 pct identical to residues 1 to 200 of 214 from Escherichia coli K-12 : B4387; hypothetical protein complement(4581902..4582546) Shigella flexneri 2a str. 2457T 1080888 NP_839796.1 CDS serB NC_004741.1 4582652 4583620 D catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 4582652..4583620 Shigella flexneri 2a str. 2457T 1080889 NP_839797.1 CDS sms NC_004741.1 4583669 4585051 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4583669..4585051 Shigella flexneri 2a str. 2457T 1080890 NP_839798.2 CDS nadR NC_004741.1 4585072 4586304 D catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 4585072..4586304 Shigella flexneri 2a str. 2457T 1080891 NP_839799.1 CDS yjjK NC_004741.1 4586612 4588279 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein complement(4586612..4588279) Shigella flexneri 2a str. 2457T 1077709 NP_839800.2 CDS slt NC_004741.1 4588490 4590427 D catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 4588490..4590427 Shigella flexneri 2a str. 2457T 1080892 NP_839801.1 CDS trpR NC_004741.1 4590517 4590843 D When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 4590517..4590843 Shigella flexneri 2a str. 2457T 1080894 NP_839802.1 CDS gpmB NC_004741.1 4591500 4592147 D catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 4591500..4592147 Shigella flexneri 2a str. 2457T 1078078 NP_839803.1 CDS rob NC_004741.1 4592144 4593013 R residues 1 to 289 of 289 are 100.00 pct identical to residues 1 to 289 of 289 from Escherichia coli K-12 : B4396; right origin-binding protein complement(4592144..4593013) Shigella flexneri 2a str. 2457T 1080895 NP_839804.1 CDS creA NC_004741.1 4593224 4593697 D residues 1 to 157 of 157 are 100.00 pct identical to residues 1 to 157 of 157 from Escherichia coli K-12 : B4397; hypothetical protein 4593224..4593697 Shigella flexneri 2a str. 2457T 1080925 NP_839805.1 CDS creB NC_004741.1 4593710 4594399 D response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 4593710..4594399 Shigella flexneri 2a str. 2457T 1080896 NP_839806.1 CDS creC NC_004741.1 4594399 4595823 D part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 4594399..4595823 Shigella flexneri 2a str. 2457T 1080897 NP_839807.1 CDS creD NC_004741.1 4595881 4597233 D residues 1 to 450 of 450 are 94.88 pct identical to residues 1 to 450 of 450 from Escherichia coli K-12 : B4400; tolerance to colicin E2; hypothetical protein 4595881..4597233 Shigella flexneri 2a str. 2457T 1080898 NP_839808.1 CDS arcA NC_004741.1 4597292 4598008 R residues 1 to 238 of 238 are 100.00 pct identical to residues 1 to 238 of 238 from Escherichia coli K-12 : B4401; two-component response regulator complement(4597292..4598008) Shigella flexneri 2a str. 2457T 1080899 NP_839809.1 CDS yjjY NC_004741.1 4598104 4598244 D residues 1 to 46 of 46 are 100.00 pct identical to residues 1 to 46 of 46 from Escherichia coli K-12 : B4402; hypothetical protein 4598104..4598244 Shigella flexneri 2a str. 2457T 1080900 NP_839810.1 CDS lasT NC_004741.1 4598644 4599330 D member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 4598644..4599330 Shigella flexneri 2a str. 2457T 1080901 S0195 tRNA ileV NC_004741.1 215765 215841 D tRNA-Ile 215765..215841 Shigella flexneri 2a str. 2457T 1076626 S0196 tRNA alaV NC_004741.1 215884 215959 D tRNA-Ala 215884..215959 Shigella flexneri 2a str. 2457T 1076619 S0199 tRNA aspU NC_004741.1 219312 219388 D tRNA-Asp 219312..219388 Shigella flexneri 2a str. 2457T 1077574 S0210 tRNA aspV NC_004741.1 228962 229038 D tRNA-Asp 228962..229038 Shigella flexneri 2a str. 2457T 1076641 S0315 tRNA thrW NC_004741.1 313753 313828 D tRNA-Thr 313753..313828 Shigella flexneri 2a str. 2457T 1076745 S0474 tRNA argU NC_004741.1 479736 479812 D tRNA-Arg 479736..479812 Shigella flexneri 2a str. 2457T 1076914 S0563 tRNA lysY NC_004741.1 572230 572305 R tRNA-Lys complement(572230..572305) Shigella flexneri 2a str. 2457T 1076999 S0564 tRNA valZ NC_004741.1 572309 572384 R tRNA-Val complement(572309..572384) Shigella flexneri 2a str. 2457T 1077002 S0565 tRNA lysW NC_004741.1 572436 572511 R tRNA-Lys complement(572436..572511) Shigella flexneri 2a str. 2457T 1077003 S0566 tRNA valT NC_004741.1 572514 572589 R tRNA-Val complement(572514..572589) Shigella flexneri 2a str. 2457T 1080354 S0567 tRNA lysT NC_004741.1 572725 572800 R tRNA-Lys complement(572725..572800) Shigella flexneri 2a str. 2457T 1077004 S0631 tRNA metT NC_004741.1 650819 650895 D tRNA-Met 650819..650895 Shigella flexneri 2a str. 2457T 1077061 S0632 tRNA leuW NC_004741.1 650904 650988 D tRNA-Leu 650904..650988 Shigella flexneri 2a str. 2457T 1077062 S0634 tRNA glnU NC_004741.1 651012 651086 D tRNA-Gln 651012..651086 Shigella flexneri 2a str. 2457T 1077063 S0636 tRNA glnW NC_004741.1 651121 651195 D tRNA-Gln 651121..651195 Shigella flexneri 2a str. 2457T 1077064 S0637 tRNA metU NC_004741.1 651211 651287 D tRNA-Met 651211..651287 Shigella flexneri 2a str. 2457T 1077065 S0639 tRNA glnV NC_004741.1 651336 651410 D tRNA-Gln 651336..651410 Shigella flexneri 2a str. 2457T 1077067 S0640 tRNA glnX NC_004741.1 651448 651522 D tRNA-Gln 651448..651522 Shigella flexneri 2a str. 2457T 1077068 S0710 tRNA S0710 NC_004741.1 709308 709384 D tRNA-Ile 709308..709384 Shigella flexneri 2a str. 2457T 1077135 S0711 tRNA S0711 NC_004741.1 709386 709462 D tRNA-Arg 709386..709462 Shigella flexneri 2a str. 2457T 1077136 S0712 tRNA S0712 NC_004741.1 709465 709539 D tRNA-Thr 709465..709539 Shigella flexneri 2a str. 2457T 1077137 S0713 tRNA S0713 NC_004741.1 709543 709617 D tRNA-Gly 709543..709617 Shigella flexneri 2a str. 2457T 1077138 S0727 tRNA S0727 NC_004741.1 718318 718394 D tRNA-Ile 718318..718394 Shigella flexneri 2a str. 2457T 1077150 S0728 tRNA S0728 NC_004741.1 718396 718472 D tRNA-Arg 718396..718472 Shigella flexneri 2a str. 2457T 1077151 S0729 tRNA S0729 NC_004741.1 718475 718550 D tRNA-Thr 718475..718550 Shigella flexneri 2a str. 2457T 1077152 S0730 tRNA S0730 NC_004741.1 718554 718628 D tRNA-Gly 718554..718628 Shigella flexneri 2a str. 2457T 1077153 S0883 tRNA serW NC_004741.1 872069 872156 R tRNA-Ser complement(872069..872156) Shigella flexneri 2a str. 2457T 1077298 S1039 tRNA serT NC_004741.1 1023509 1023596 R tRNA-Ser complement(1023509..1023596) Shigella flexneri 2a str. 2457T 1077441 S1099 tRNA serX NC_004741.1 1076674 1076761 R tRNA-Ser complement(1076674..1076761) Shigella flexneri 2a str. 2457T 1077497 S1317 tRNA tyrT NC_004741.1 1282470 1282554 R tRNA-Tyr complement(1282470..1282554) Shigella flexneri 2a str. 2457T 1077688 S1662 tRNA S1662 NC_004741.1 1616401 1616477 R tRNA-Arg complement(1616401..1616477) Shigella flexneri 2a str. 2457T 1078054 S1663 tRNA S1663 NC_004741.1 1616579 1616654 R tRNA-Ile complement(1616579..1616654) Shigella flexneri 2a str. 2457T 1078196 S1825 tRNA valV NC_004741.1 1765714 1765790 D tRNA-Val 1765714..1765790 Shigella flexneri 2a str. 2457T 1078159 S1826 tRNA valW NC_004741.1 1765795 1765871 D tRNA-Val 1765795..1765871 Shigella flexneri 2a str. 2457T 1078162 S1982 tRNA S1982 NC_004741.1 1914353 1914427 R tRNA-Gly complement(1914353..1914427) Shigella flexneri 2a str. 2457T 1078309 S1983 tRNA S1983 NC_004741.1 1914431 1914506 R tRNA-Thr complement(1914431..1914506) Shigella flexneri 2a str. 2457T 1078310 S1984 tRNA S1984 NC_004741.1 1914509 1914585 R tRNA-Arg complement(1914509..1914585) Shigella flexneri 2a str. 2457T 1078312 S1985 tRNA S1985 NC_004741.1 1914587 1914662 R tRNA-Ile complement(1914587..1914662) Shigella flexneri 2a str. 2457T 1078113 S2048 tRNA leuZ NC_004741.1 1964753 1964839 R tRNA-Leu complement(1964753..1964839) Shigella flexneri 2a str. 2457T 1078366 S2049 tRNA cysT NC_004741.1 1964852 1964925 R tRNA-Cys complement(1964852..1964925) Shigella flexneri 2a str. 2457T 1078367 S2050 tRNA glyW NC_004741.1 1964980 1965055 R tRNA-Gly complement(1964980..1965055) Shigella flexneri 2a str. 2457T 1078368 S2137a tRNA S2137a NC_004741.1 2036237 2036308 R tRNA-Gly complement(2036237..2036308) Shigella flexneri 2a str. 2457T 6372719 S2137 tRNA S2137 NC_004741.1 2036312 2036387 R tRNA-Thr complement(2036312..2036387) Shigella flexneri 2a str. 2457T 1076771 S2138 tRNA S2138 NC_004741.1 2036468 2036543 R tRNA-Ile complement(2036468..2036543) Shigella flexneri 2a str. 2457T 1079024 S2147 tRNA S2147 NC_004741.1 2041762 2041851 R tRNA-Ser complement(2041762..2041851) Shigella flexneri 2a str. 2457T 1078456 S2149 tRNA S2149 NC_004741.1 2042843 2042918 D tRNA-Asn 2042843..2042918 Shigella flexneri 2a str. 2457T 1078457 S2162 tRNA asnW NC_004741.1 2050720 2050795 R tRNA-Asn complement(2050720..2050795) Shigella flexneri 2a str. 2457T 1078467 S2164 tRNA asnU NC_004741.1 2052528 2052603 D tRNA-Asn 2052528..2052603 Shigella flexneri 2a str. 2457T 1078470 S2167 tRNA asnV NC_004741.1 2054938 2055013 D tRNA-Asn 2054938..2055013 Shigella flexneri 2a str. 2457T 1078473 S2405 tRNA proL NC_004741.1 2288868 2288944 D tRNA-Pro 2288868..2288944 Shigella flexneri 2a str. 2457T 1078696 S2561 tRNA argW NC_004741.1 2454726 2454800 D tRNA-Arg 2454726..2454800 Shigella flexneri 2a str. 2457T 1078843 S2601 tRNA alaX NC_004741.1 2497591 2497666 R tRNA-Ala complement(2497591..2497666) Shigella flexneri 2a str. 2457T 1078873 S2602 tRNA alaW NC_004741.1 2497706 2497781 R tRNA-Ala complement(2497706..2497781) Shigella flexneri 2a str. 2457T 1078874 S2606 tRNA valX NC_004741.1 2500481 2500556 D tRNA-Val 2500481..2500556 Shigella flexneri 2a str. 2457T 1078878 S2607 tRNA valY NC_004741.1 2500601 2500676 D tRNA-Val 2500601..2500676 Shigella flexneri 2a str. 2457T 1078879 S2608 tRNA lysV NC_004741.1 2500681 2500756 D tRNA-Lys 2500681..2500756 Shigella flexneri 2a str. 2457T 1078880 S2825 tRNA gltW NC_004741.1 2719865 2719940 R tRNA-Glu complement(2719865..2719940) Shigella flexneri 2a str. 2457T 1079089 S2864 tRNA ileY NC_004741.1 2753003 2753078 R tRNA-Ile complement(2753003..2753078) Shigella flexneri 2a str. 2457T 1079129 S2905 tRNA argQ NC_004741.1 2786184 2786260 R tRNA-Arg complement(2786184..2786260) Shigella flexneri 2a str. 2457T 1079170 S2906 tRNA argZ NC_004741.1 2786325 2786401 R tRNA-Arg complement(2786325..2786401) Shigella flexneri 2a str. 2457T 1079171 S2907 tRNA argY NC_004741.1 2786466 2786542 R tRNA-Arg complement(2786466..2786542) Shigella flexneri 2a str. 2457T 1079172 S2908 tRNA argV NC_004741.1 2786607 2786683 R tRNA-Arg complement(2786607..2786683) Shigella flexneri 2a str. 2457T 1079173 S2909 tRNA serV NC_004741.1 2786687 2786779 R tRNA-Ser complement(2786687..2786779) Shigella flexneri 2a str. 2457T 1079174 S3023 tRNA metZ NC_004741.1 2902512 2902588 D tRNA-Met 2902512..2902588 Shigella flexneri 2a str. 2457T 1077625 S3024 tRNA metW NC_004741.1 2902622 2902698 D tRNA-Met 2902622..2902698 Shigella flexneri 2a str. 2457T 1079292 S3066 tRNA glyU NC_004741.1 2951077 2951150 R tRNA-Gly complement(2951077..2951150) Shigella flexneri 2a str. 2457T 1078678 S3167 tRNA pheV NC_004741.1 3044640 3044715 D tRNA-Phe 3044640..3044715 Shigella flexneri 2a str. 2457T 1079432 S3316 tRNA ileX NC_004741.1 3194737 3194812 D tRNA-Ile 3194737..3194812 Shigella flexneri 2a str. 2457T 1079558 S3429 tRNA metY NC_004741.1 3301512 3301588 R tRNA-Met complement(3301512..3301588) Shigella flexneri 2a str. 2457T 1079666 S3432 tRNA leuU NC_004741.1 3305372 3305458 R tRNA-Leu complement(3305372..3305458) Shigella flexneri 2a str. 2457T 1079669 S3529 tRNA thrV NC_004741.1 3396538 3396613 R tRNA-Thr complement(3396538..3396613) Shigella flexneri 2a str. 2457T 1079754 S3532 tRNA alaU NC_004741.1 3399926 3400001 R tRNA-Ala complement(3399926..3400001) Shigella flexneri 2a str. 2457T 1079756 S3533 tRNA ileU NC_004741.1 3400044 3400120 R tRNA-Ile complement(3400044..3400120) Shigella flexneri 2a str. 2457T 1078200 S3655 tRNA gltV NC_004741.1 3544410 3544485 R tRNA-Glu complement(3544410..3544485) Shigella flexneri 2a str. 2457T 1079875 S3683 tRNA thrT NC_004741.1 3577637 3577712 R tRNA-Thr complement(3577637..3577712) Shigella flexneri 2a str. 2457T 1080790 S3684 tRNA glyT NC_004741.1 3577719 3577793 R tRNA-Gly complement(3577719..3577793) Shigella flexneri 2a str. 2457T 1079901 S3685 tRNA tyrU NC_004741.1 3577910 3577994 R tRNA-Tyr complement(3577910..3577994) Shigella flexneri 2a str. 2457T 1080920 S3686 tRNA thrU NC_004741.1 3578003 3578078 R tRNA-Thr complement(3578003..3578078) Shigella flexneri 2a str. 2457T 1079903 S3693 tRNA gltT NC_004741.1 3584846 3584921 R tRNA-Glu complement(3584846..3584921) Shigella flexneri 2a str. 2457T 1079911 S3823 tRNA alaT NC_004741.1 3723026 3723101 R tRNA-Ala complement(3723026..3723101) Shigella flexneri 2a str. 2457T 1080039 S3824 tRNA ileT NC_004741.1 3723144 3723220 R tRNA-Ile complement(3723144..3723220) Shigella flexneri 2a str. 2457T 1080040 S3886 tRNA proM NC_004741.1 3781918 3781994 R tRNA-Pro complement(3781918..3781994) Shigella flexneri 2a str. 2457T 1080104 S3887 tRNA leuT NC_004741.1 3782037 3782123 R tRNA-Leu complement(3782037..3782123) Shigella flexneri 2a str. 2457T 1080105 S3888 tRNA hisR NC_004741.1 3782144 3782219 R tRNA-His complement(3782144..3782219) Shigella flexneri 2a str. 2457T 1080107 S3889 tRNA argX NC_004741.1 3782278 3782354 R tRNA-Arg complement(3782278..3782354) Shigella flexneri 2a str. 2457T 1080108 S3923 tRNA trpT NC_004741.1 3816778 3816853 R tRNA-Trp complement(3816778..3816853) Shigella flexneri 2a str. 2457T 1080136 S3924 tRNA aspT NC_004741.1 3816862 3816938 R tRNA-Asp complement(3816862..3816938) Shigella flexneri 2a str. 2457T 1080137 S3927 tRNA gltU NC_004741.1 3820301 3820376 R tRNA-Glu complement(3820301..3820376) Shigella flexneri 2a str. 2457T 1080140 S4071 tRNA selC NC_004741.1 3968763 3968853 R tRNA-Sec complement(3968763..3968853) Shigella flexneri 2a str. 2457T 1080278 S4190 tRNA proK NC_004741.1 4095462 4095538 D tRNA-Pro 4095462..4095538 Shigella flexneri 2a str. 2457T 1080396 S4485 tRNA leuX NC_004741.1 4388344 4388428 R tRNA-Leu complement(4388344..4388428) Shigella flexneri 2a str. 2457T 1080690 S4555 tRNA pheU NC_004741.1 4458364 4458439 R tRNA-Phe complement(4458364..4458439) Shigella flexneri 2a str. 2457T 1080762 S4585 tRNA glyV NC_004741.1 4489107 4489182 D tRNA-Gly 4489107..4489182 Shigella flexneri 2a str. 2457T 1080954 S4586 tRNA glyX NC_004741.1 4489340 4489415 D tRNA-Gly 4489340..4489415 Shigella flexneri 2a str. 2457T 1080947 S4587 tRNA glyY NC_004741.1 4489451 4489526 D tRNA-Gly 4489451..4489526 Shigella flexneri 2a str. 2457T 1080793 S4588 tRNA S4588 NC_004741.1 4489562 4489637 D tRNA-Gly 4489562..4489637 Shigella flexneri 2a str. 2457T 1080794 S4671 tRNA leuV NC_004741.1 4565093 4565179 R tRNA-Leu complement(4565093..4565179) Shigella flexneri 2a str. 2457T 1080868 S4672 tRNA leuP NC_004741.1 4565214 4565300 R tRNA-Leu complement(4565214..4565300) Shigella flexneri 2a str. 2457T 1080869 S4673 tRNA leuQ NC_004741.1 4565329 4565415 R tRNA-Leu complement(4565329..4565415) Shigella flexneri 2a str. 2457T 1080870 S0194 rRNA rrsH NC_004741.1 214156 215696 D 16S ribosomal RNA 214156..215696 Shigella flexneri 2a str. 2457T 1076624 S0197 rRNA rrlH NC_004741.1 216143 219046 D 23S ribosomal RNA 216143..219046 Shigella flexneri 2a str. 2457T 1077820 S0198 rRNA rrfH NC_004741.1 219141 219259 D 5S ribosomal RNA 219141..219259 Shigella flexneri 2a str. 2457T 1076628 S2823 rRNA rrfG NC_004741.1 2716555 2716673 R 5S ribosomal RNA complement(2716555..2716673) Shigella flexneri 2a str. 2457T 1079087 S2824 rRNA rrlG NC_004741.1 2716768 2719671 R 23S ribosomal RNA complement(2716768..2719671) Shigella flexneri 2a str. 2457T 1079088 S2826 rRNA rrsG NC_004741.1 2720026 2721566 R 16S ribosomal RNA complement(2720026..2721566) Shigella flexneri 2a str. 2457T 1079090 S3528 rRNA rrfF NC_004741.1 3396385 3396497 R 5S ribosomal RNA complement(3396385..3396497) Shigella flexneri 2a str. 2457T 1079753 S3530 rRNA rrfD NC_004741.1 3396626 3396744 R 5S ribosomal RNA complement(3396626..3396744) Shigella flexneri 2a str. 2457T 1079755 S3531 rRNA rrlD NC_004741.1 3396839 3399742 R 23S ribosomal RNA complement(3396839..3399742) Shigella flexneri 2a str. 2457T 1080904 S3534 rRNA rrsD NC_004741.1 3400189 3401730 R 16S ribosomal RNA complement(3400189..3401730) Shigella flexneri 2a str. 2457T 1079757 S3653 rRNA rrfE NC_004741.1 3541100 3541218 R 5S ribosomal RNA complement(3541100..3541218) Shigella flexneri 2a str. 2457T 1079873 S3654 rRNA rrlE NC_004741.1 3541313 3544216 R 23S ribosomal RNA complement(3541313..3544216) Shigella flexneri 2a str. 2457T 1079874 S3656 rRNA rrsE NC_004741.1 3544571 3546112 R 16S ribosomal RNA complement(3544571..3546112) Shigella flexneri 2a str. 2457T 1079876 S3691 rRNA rrfB NC_004741.1 3581536 3581654 R 5S ribosomal RNA complement(3581536..3581654) Shigella flexneri 2a str. 2457T 1079908 S3692 rRNA rrlB NC_004741.1 3581749 3584652 R 23S ribosomal RNA complement(3581749..3584652) Shigella flexneri 2a str. 2457T 1079909 S3694 rRNA rrsB NC_004741.1 3585007 3586548 R 16S ribosomal RNA complement(3585007..3586548) Shigella flexneri 2a str. 2457T 1079912 S3821 rRNA rrfA NC_004741.1 3719726 3719844 R 5S ribosomal RNA complement(3719726..3719844) Shigella flexneri 2a str. 2457T 1080036 S3822 rRNA rrlA NC_004741.1 3719939 3722842 R 23S ribosomal RNA complement(3719939..3722842) Shigella flexneri 2a str. 2457T 1080037 S3825 rRNA rrsA NC_004741.1 3723289 3724830 R 16S ribosomal RNA complement(3723289..3724830) Shigella flexneri 2a str. 2457T 1080041 S3925 rRNA rrfC NC_004741.1 3816991 3817109 R 5S ribosomal RNA complement(3816991..3817109) Shigella flexneri 2a str. 2457T 1080138 S3926 rRNA rrlC NC_004741.1 3817204 3820107 R 23S ribosomal RNA complement(3817204..3820107) Shigella flexneri 2a str. 2457T 1080139 S3928 rRNA rrsC NC_004741.1 3820462 3822003 R 16S ribosomal RNA complement(3820462..3822003) Shigella flexneri 2a str. 2457T 1080141