-- dump date 20140620_065240 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_835743.1 30061572 1076421 190..255 1 NC_004741.1 residues 1 to 21 of 21 are 100 pct identical to residues 1 to 21 of 21 from Escherichia coli K-12 : B0001; thr operon leader peptide 255 thrL 1076421 thrL Shigella flexneri 2a str. 2457T thr operon leader peptide NP_835743.1 190 D 198215 CDS NP_835744.1 30061573 1076422 336..2798 1 NC_004741.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homeserine dehydrogenase I 2798 thrA 1076422 thrA Shigella flexneri 2a str. 2457T bifunctional aspartokinase I/homeserine dehydrogenase I NP_835744.1 336 D 198215 CDS NP_835745.1 30061574 1076423 2800..3732 1 NC_004741.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3732 thrB 1076423 thrB Shigella flexneri 2a str. 2457T homoserine kinase NP_835745.1 2800 D 198215 CDS NP_835746.1 30061575 1076424 3733..5019 1 NC_004741.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5019 thrC 1076424 thrC Shigella flexneri 2a str. 2457T threonine synthase NP_835746.1 3733 D 198215 CDS NP_835747.1 30061576 1076425 5242..5529 1 NC_004741.1 residues 1 to 65 of 95 are 60.00 pct identical to residues 4 to 68 of 98 from Escherichia coli K-12 : B0005; hypothetical protein 5529 1076425 S0005 Shigella flexneri 2a str. 2457T hypothetical protein NP_835747.1 5242 D 198215 CDS NP_835748.1 30061577 1076426 complement(5682..6458) 1 NC_004741.1 residues 1 to 258 of 258 are 100.00 pct identical to residues 1 to 258 of 258 from Escherichia coli K-12 : B0006; hypothetical protein 6458 yaaA 1076426 yaaA Shigella flexneri 2a str. 2457T hypothetical protein NP_835748.1 5682 R 198215 CDS NP_835749.1 30061578 1076428 8237..9190 1 NC_004741.1 Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase B 9190 talB 1076428 talB Shigella flexneri 2a str. 2457T transaldolase B NP_835749.1 8237 D 198215 CDS NP_835750.1 30061579 1076431 9305..9892 1 NC_004741.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein 9892 mogA 1076431 mogA Shigella flexneri 2a str. 2457T molybdenum cofactor biosynthesis protein NP_835750.1 9305 D 198215 CDS NP_835751.1 30061580 1077111 complement(9927..10493) 1 NC_004741.1 residues 1 to 188 of 188 are 92.02 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 : B0010; hypothetical protein 10493 yaaH 1077111 yaaH Shigella flexneri 2a str. 2457T hypothetical protein NP_835751.1 9927 R 198215 CDS NP_835752.1 30061581 1078121 complement(10642..11355) 1 NC_004741.1 residues 1 to 237 of 237 are 82.27 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B0011; hypothetical protein 11355 1078121 S0012 Shigella flexneri 2a str. 2457T hypothetical protein NP_835752.1 10642 R 198215 CDS NP_835754.1 30061583 1079962 complement(11381..11785) 1 NC_004741.1 residues 1 to 134 of 134 are 99.25 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B0013; hypothetical protein 11785 yaaI 1079962 yaaI Shigella flexneri 2a str. 2457T hypothetical protein NP_835754.1 11381 R 198215 CDS NP_835755.1 30061584 1080997 12162..14078 1 NC_004741.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 14078 dnaK 1080997 dnaK Shigella flexneri 2a str. 2457T molecular chaperone DnaK NP_835755.1 12162 D 198215 CDS NP_835756.1 30061585 1080998 14167..15297 1 NC_004741.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 15297 dnaJ 1080998 dnaJ Shigella flexneri 2a str. 2457T chaperone protein DnaJ NP_835756.1 14167 D 198215 CDS NP_835757.1 30061586 1076443 complement(15401..15610) 1 NC_004741.1 residues 1 to 69 of 69 are 100.00 pct identical to residues 1 to 69 of 69 from Escherichia coli K-12 : B0018; regulated cell killing; membrane toxin 15610 gef 1076443 gef Shigella flexneri 2a str. 2457T membrane toxin NP_835757.1 15401 R 198215 CDS NP_835758.1 30061587 1078430 16139..17305 1 NC_004741.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 17305 nhaA 1078430 nhaA Shigella flexneri 2a str. 2457T pH-dependent sodium/proton antiporter NP_835758.1 16139 D 198215 CDS NP_835759.1 30061588 1078188 17371..18270 1 NC_004741.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 18270 nhaR 1078188 nhaR Shigella flexneri 2a str. 2457T transcriptional activator NhaR NP_835759.1 17371 D 198215 CDS NP_835760.1 30061589 1077777 complement(18683..19186) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 19186 1077777 S0020 Shigella flexneri 2a str. 2457T IS1 orfB NP_835760.1 18683 R 198215 CDS NP_835761.1 30061590 1077582 complement(19105..19380) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 19380 1077582 S0021 Shigella flexneri 2a str. 2457T IS1 orfA NP_835761.1 19105 R 198215 CDS NP_835762.2 161486555 1076778 complement(19769..20032) 1 NC_004741.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 20032 rpsT 1076778 rpsT Shigella flexneri 2a str. 2457T 30S ribosomal protein S20 NP_835762.2 19769 R 198215 CDS NP_835763.1 30061592 1076482 20135..20353 1 NC_004741.1 residues 1 to 72 of 72 are 98.61 pct identical to residues 1 to 72 of 72 from Escherichia coli K-12 : B0024; hypothetical protein 20353 1076482 S0023 Shigella flexneri 2a str. 2457T hypothetical protein NP_835763.1 20135 D 198215 CDS NP_835764.1 30061593 1076481 20361..21302 1 NC_004741.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 21302 ribF 1076481 ribF Shigella flexneri 2a str. 2457T bifunctional riboflavin kinase/FMN adenylyltransferase NP_835764.1 20361 D 198215 CDS NP_835765.1 30061594 1076478 21345..24161 1 NC_004741.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 24161 ileS 1076478 ileS Shigella flexneri 2a str. 2457T isoleucyl-tRNA synthetase NP_835765.1 21345 D 198215 CDS NP_835766.1 30061595 1076476 24161..24655 1 NC_004741.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 24655 lspA 1076476 lspA Shigella flexneri 2a str. 2457T lipoprotein signal peptidase NP_835766.1 24161 D 198215 CDS NP_835767.1 30061596 1076475 24742..25191 1 NC_004741.1 residues 1 to 149 of 149 are 100.00 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B0028; FKBX-type 16kD peptidyl-prolyl cis-trans isomerase (a rotamase) 25191 slpA 1076475 slpA Shigella flexneri 2a str. 2457T FKBX-type 16kD peptidyl-prolyl cis-trans isomerase (a rotamase) NP_835767.1 24742 D 198215 CDS NP_835768.1 30061597 1076472 25193..26143 1 NC_004741.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 26143 ispH 1076472 ispH Shigella flexneri 2a str. 2457T 4-hydroxy-3-methylbut-2-enyl diphosphate reductase NP_835768.1 25193 D 198215 CDS NP_835769.1 30061598 1076471 26209..27123 1 NC_004741.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 27123 yaaF 1076471 yaaF Shigella flexneri 2a str. 2457T ribonucleoside hydrolase RihC NP_835769.1 26209 D 198215 CDS NP_835770.1 30061599 1076470 27290..28111 1 NC_004741.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 28111 dapB 1076470 dapB Shigella flexneri 2a str. 2457T dihydrodipicolinate reductase NP_835770.1 27290 D 198215 CDS NP_835771.1 30061600 1076468 28567..29715 1 NC_004741.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 29715 carA 1076468 carA Shigella flexneri 2a str. 2457T carbamoyl phosphate synthase small subunit NP_835771.1 28567 D 198215 CDS NP_835772.1 30061601 1076467 29733..32954 1 NC_004741.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 32954 carB 1076467 carB Shigella flexneri 2a str. 2457T carbamoyl phosphate synthase large subunit NP_835772.1 29733 D 198215 CDS NP_835773.2 161486554 1076466 33216..33611 1 NC_004741.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 33611 caiF 1076466 caiF Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator CaiF NP_835773.2 33216 D 198215 CDS NP_835774.1 30061603 1076465 complement(33697..34308) 1 NC_004741.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 34308 caiE 1076465 caiE Shigella flexneri 2a str. 2457T carnitine operon protein CaiE NP_835774.1 33697 R 198215 CDS NP_835775.1 30061604 1076464 complement(34293..35186) 1 NC_004741.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 35186 caiD 1076464 caiD Shigella flexneri 2a str. 2457T carnitinyl-CoA dehydratase NP_835775.1 34293 R 198215 CDS NP_835776.1 30061605 1076463 complement(35187..36755) 1 NC_004741.1 residues 1 to 522 of 522 are 95.59 pct identical to residues 1 to 522 of 522 from Escherichia coli K-12 : B0037; crotonobetaine/carnitine-CoA ligase 36755 caiC 1076463 caiC Shigella flexneri 2a str. 2457T crotonobetaine/carnitine-CoA ligase NP_835776.1 35187 R 198215 CDS NP_835777.1 30061606 1076459 complement(36814..38031) 1 NC_004741.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase 38031 caiB 1076459 caiB Shigella flexneri 2a str. 2457T crotonobetainyl-CoA:carnitine CoA-transferase NP_835777.1 36814 R 198215 CDS NP_835778.1 30061607 1076456 complement(38160..39302) 1 NC_004741.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 39302 caiA 1076456 caiA Shigella flexneri 2a str. 2457T crotonobetainyl-CoA dehydrogenase NP_835778.1 38160 R 198215 CDS NP_835779.1 30061608 1076454 complement(39333..40847) 1 NC_004741.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 40847 caiT 1076454 caiT Shigella flexneri 2a str. 2457T L-carnitine/gamma-butyrobetaine antiporter NP_835779.1 39333 R 198215 CDS NP_835780.2 161486553 1076453 41203..41973 1 NC_004741.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; electron transfer flavoprotein FixA 41973 fixA 1076453 fixA Shigella flexneri 2a str. 2457T electron transfer flavoprotein FixA NP_835780.2 41203 D 198215 CDS NP_835781.1 30061610 1076449 42980..44266 1 NC_004741.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; oxidoreductase FixC 44266 fixC 1076449 fixC Shigella flexneri 2a str. 2457T oxidoreductase FixC NP_835781.1 42980 D 198215 CDS NP_835782.1 30061611 1076448 44263..44550 1 NC_004741.1 residues 1 to 95 of 95 are 98.94 pct identical to residues 1 to 95 of 95 from Escherichia coli K-12 : B0044; ferredoxin 44550 fixX 1076448 fixX Shigella flexneri 2a str. 2457T ferredoxin NP_835782.1 44263 D 198215 CDS NP_835783.1 30061612 1076446 44609..46003 1 NC_004741.1 residues 1 to 443 of 464 are 97.06 pct identical to residues 1 to 443 of 443 from Escherichia coli K-12 : B0045; transporter 46003 yaaU 1076446 yaaU Shigella flexneri 2a str. 2457T transporter NP_835783.1 44609 D 198215 CDS NP_835784.1 30061613 1076445 46051..46581 1 NC_004741.1 Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 46581 yabF 1076445 yabF Shigella flexneri 2a str. 2457T glutathione-regulated potassium-efflux system ancillary protein KefF NP_835784.1 46051 D 198215 CDS NP_835785.1 30061614 1076444 46574..48436 1 NC_004741.1 transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 48436 kefC 1076444 kefC Shigella flexneri 2a str. 2457T glutathione-regulated potassium-efflux system protein KefC NP_835785.1 46574 D 198215 CDS NP_835786.1 30061615 1076432 48627..49106 1 NC_004741.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 49106 folA 1076432 folA Shigella flexneri 2a str. 2457T dihydrofolate reductase NP_835786.1 48627 D 198215 CDS NP_835787.1 30061616 1076433 complement(49184..50026) 1 NC_004741.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 50026 apaH 1076433 apaH Shigella flexneri 2a str. 2457T diadenosine tetraphosphatase NP_835787.1 49184 R 198215 CDS NP_835788.1 30061617 1076885 complement(50033..50410) 1 NC_004741.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 50410 apaG 1076885 apaG Shigella flexneri 2a str. 2457T ApaG protein NP_835788.1 50033 R 198215 CDS NP_835789.1 30061618 1076435 complement(50413..51234) 1 NC_004741.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 51234 ksgA 1076435 ksgA Shigella flexneri 2a str. 2457T dimethyladenosine transferase NP_835789.1 50413 R 198215 CDS NP_835790.1 30061619 1078040 complement(51231..52220) 1 NC_004741.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 52220 pdxA 1078040 pdxA Shigella flexneri 2a str. 2457T 4-hydroxythreonine-4-phosphate dehydrogenase NP_835790.1 51231 R 198215 CDS NP_835791.1 30061620 1076439 complement(52220..53506) 1 NC_004741.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA 53506 surA 1076439 surA Shigella flexneri 2a str. 2457T peptidyl-prolyl cis-trans isomerase SurA NP_835791.1 52220 R 198215 CDS NP_835792.1 30061621 1076437 complement(53559..55913) 1 NC_004741.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 55913 imp 1076437 imp Shigella flexneri 2a str. 2457T organic solvent tolerance protein NP_835792.1 53559 R 198215 CDS NP_835793.1 30061622 1076509 56168..56983 1 NC_004741.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 56983 djlA 1076509 djlA Shigella flexneri 2a str. 2457T Dna-J like membrane chaperone protein NP_835793.1 56168 D 198215 CDS NP_835794.1 30061623 1076488 complement(57100..57759) 1 NC_004741.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 57759 yabO 1076488 yabO Shigella flexneri 2a str. 2457T 23S rRNA/tRNA pseudouridine synthase A NP_835794.1 57100 R 198215 CDS NP_835795.1 30061624 1076440 complement(57771..60677) 1 NC_004741.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 60677 hepA 1076440 hepA Shigella flexneri 2a str. 2457T ATP-dependent helicase HepA NP_835795.1 57771 R 198215 CDS NP_835796.1 30061625 1076441 complement(60842..63193) 1 NC_004741.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II 63193 polB 1076441 polB Shigella flexneri 2a str. 2457T DNA polymerase II NP_835796.1 60842 R 198215 CDS NP_835797.1 30061626 1080994 complement(63268..63963) 1 NC_004741.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 63963 araD 1080994 araD Shigella flexneri 2a str. 2457T L-ribulose-5-phosphate 4-epimerase NP_835797.1 63268 R 198215 CDS NP_835798.1 30061627 1079821 complement(64163..65665) 1 NC_004741.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 65665 araA 1079821 araA Shigella flexneri 2a str. 2457T L-arabinose isomerase NP_835798.1 64163 R 198215 CDS NP_835799.1 30061628 1079740 complement(65676..67376) 1 NC_004741.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 67376 araB 1079740 araB Shigella flexneri 2a str. 2457T ribulokinase NP_835799.1 65676 R 198215 CDS NP_835800.1 30061629 1077806 67715..68593 1 NC_004741.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 68593 araC 1077806 araC Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator AraC NP_835800.1 67715 D 198215 CDS NP_835801.1 30061630 1076494 68679..69443 1 NC_004741.1 residues 1 to 254 of 254 are 99.21 pct identical to residues 1 to 254 of 254 from Escherichia coli K-12 : B0065; hypothetical protein 69443 yabI 1076494 yabI Shigella flexneri 2a str. 2457T hypothetical protein NP_835801.1 68679 D 198215 CDS NP_835802.1 30061631 1076495 complement(69557..70255) 1 NC_004741.1 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit 70255 thiQ 1076495 thiQ Shigella flexneri 2a str. 2457T thiamine transporter ATP-binding subunit NP_835802.1 69557 R 198215 CDS NP_835803.1 30061632 1076814 complement(70239..71849) 1 NC_004741.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 71849 thiP 1076814 thiP Shigella flexneri 2a str. 2457T thiamine transporter membrane protein NP_835803.1 70239 R 198215 CDS NP_835804.1 30061633 1076496 complement(71825..72808) 1 NC_004741.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 72808 tbpA 1076496 tbpA Shigella flexneri 2a str. 2457T thiamine transporter substrate binding subunit NP_835804.1 71825 R 198215 CDS NP_835805.1 30061634 1080991 complement(72972..74627) 1 NC_004741.1 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 74627 yabN 1080991 yabN Shigella flexneri 2a str. 2457T transcriptional regulator SgrR NP_835805.1 72972 R 198215 CDS NP_835806.1 30061635 1076497 74949..76127 1 NC_004741.1 residues 1 to 392 of 392 are 97.95 pct identical to residues 1 to 392 of 392 from Escherichia coli K-12 : B0070; transporter 76127 yabM 1076497 yabM Shigella flexneri 2a str. 2457T transporter NP_835806.1 74949 D 198215 CDS NP_835807.1 30061636 1076498 complement(76176..76781) 1 NC_004741.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 76781 leuD 1076498 leuD Shigella flexneri 2a str. 2457T isopropylmalate isomerase small subunit NP_835807.1 76176 R 198215 CDS NP_835808.1 30061637 1076499 complement(76792..78192) 1 NC_004741.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 78192 leuC 1076499 leuC Shigella flexneri 2a str. 2457T isopropylmalate isomerase large subunit NP_835808.1 76792 R 198215 CDS NP_835809.2 161486552 1079376 complement(78195..79286) 1 NC_004741.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 79286 leuB 1079376 leuB Shigella flexneri 2a str. 2457T 3-isopropylmalate dehydrogenase NP_835809.2 78195 R 198215 CDS NP_835810.1 30061639 1076500 complement(79286..80857) 1 NC_004741.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 80857 leuA 1076500 leuA Shigella flexneri 2a str. 2457T 2-isopropylmalate synthase NP_835810.1 79286 R 198215 CDS NP_835811.1 30061640 1076501 complement(80950..81036) 1 NC_004741.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide 81036 leuL 1076501 leuL Shigella flexneri 2a str. 2457T leu operon leader peptide NP_835811.1 80950 R 198215 CDS NP_835812.2 161486551 1076503 81695..82639 1 NC_004741.1 activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 82639 leuO 1076503 leuO Shigella flexneri 2a str. 2457T leucine transcriptional activator NP_835812.2 81695 D 198215 CDS NP_835813.2 161486550 1076504 82957..84681 1 NC_004741.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 84681 ilvI 1076504 ilvI Shigella flexneri 2a str. 2457T acetolactate synthase 3 catalytic subunit NP_835813.2 82957 D 198215 CDS NP_835814.1 30061643 1076505 84684..85175 1 NC_004741.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 85175 ilvH 1076505 ilvH Shigella flexneri 2a str. 2457T acetolactate synthase 3 regulatory subunit NP_835814.1 84684 D 198215 CDS NP_835816.1 30061645 1076507 85356..86360 1 NC_004741.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 86360 fruR 1076507 fruR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator FruR NP_835816.1 85356 D 198215 CDS NP_835817.1 30061646 1076508 86483..86758 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 86758 1076508 S0078 Shigella flexneri 2a str. 2457T IS1 orfA NP_835817.1 86483 D 198215 CDS NP_835818.1 30061647 1076510 86677..87180 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 87180 1076510 S0079 Shigella flexneri 2a str. 2457T IS1 orfB NP_835818.1 86677 D 198215 CDS NP_835819.1 30061648 1076511 87739..88197 1 NC_004741.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 88197 yabB 1076511 yabB Shigella flexneri 2a str. 2457T cell division protein MraZ NP_835819.1 87739 D 198215 CDS NP_835820.1 30061649 1078667 88199..89140 1 NC_004741.1 residues 1 to 313 of 313 are 95.20 pct identical to residues 1 to 313 of 313 from Escherichia coli K-12 : B0082; S-adenosyl-methyltransferase MraW 89140 mraW 1078667 mraW Shigella flexneri 2a str. 2457T S-adenosyl-methyltransferase MraW NP_835820.1 88199 D 198215 CDS NP_835821.1 30061650 1076512 89137..89502 1 NC_004741.1 membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 89502 ftsL 1076512 ftsL Shigella flexneri 2a str. 2457T cell division protein FtsL NP_835821.1 89137 D 198215 CDS NP_835822.1 30061651 1076513 89518..91284 1 NC_004741.1 residues 1 to 588 of 588 are 96.76 pct identical to residues 1 to 588 of 588 from Escherichia coli K-12 : B0084; involved in septum formation; penicillin-binding protein 3; peptidoglycan synthetase 91284 ftsI 1076513 ftsI Shigella flexneri 2a str. 2457T penicillin-binding protein 3; peptidoglycan synthetase NP_835822.1 89518 D 198215 CDS NP_835823.1 30061652 1076514 91271..92758 1 NC_004741.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 92758 murE 1076514 murE Shigella flexneri 2a str. 2457T UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase NP_835823.1 91271 D 198215 CDS NP_835824.1 30061653 1076515 92755..94113 1 NC_004741.1 residues 1 to 452 of 452 are 94.91 pct identical to residues 1 to 452 of 452 from Escherichia coli K-12 : B0086; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 94113 murF 1076515 murF Shigella flexneri 2a str. 2457T UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase NP_835824.1 92755 D 198215 CDS NP_835825.1 30061654 1076516 94107..95189 1 NC_004741.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 95189 mraY 1076516 mraY Shigella flexneri 2a str. 2457T phospho-N-acetylmuramoyl-pentapeptide- transferase NP_835825.1 94107 D 198215 CDS NP_835826.1 30061655 1076517 95192..96508 1 NC_004741.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 96508 murD 1076517 murD Shigella flexneri 2a str. 2457T UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase NP_835826.1 95192 D 198215 CDS NP_835827.1 30061656 1076518 96508..97752 1 NC_004741.1 integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 97752 ftsW 1076518 ftsW Shigella flexneri 2a str. 2457T cell division protein FtsW NP_835827.1 96508 D 198215 CDS NP_835828.1 30061657 1076519 97749..98816 1 NC_004741.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 98816 murG 1076519 murG Shigella flexneri 2a str. 2457T undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase NP_835828.1 97749 D 198215 CDS NP_835829.1 30061658 1078273 98870..100345 1 NC_004741.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 100345 murC 1078273 murC Shigella flexneri 2a str. 2457T UDP-N-acetylmuramate--L-alanine ligase NP_835829.1 98870 D 198215 CDS NP_835830.1 30061659 1076520 100338..101258 1 NC_004741.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 101258 ddl 1076520 ddl Shigella flexneri 2a str. 2457T D-alanine--D-alanine ligase NP_835830.1 100338 D 198215 CDS NP_835831.1 30061660 1076521 101260..102090 1 NC_004741.1 involved in septum formation; cell division protein FtsQ 102090 ftsQ 1076521 ftsQ Shigella flexneri 2a str. 2457T cell division protein FtsQ NP_835831.1 101260 D 198215 CDS NP_835832.1 30061661 1076522 102087..103349 1 NC_004741.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 103349 ftsA 1076522 ftsA Shigella flexneri 2a str. 2457T cell division protein FtsA NP_835832.1 102087 D 198215 CDS NP_835833.1 30061662 1076523 103410..104561 1 NC_004741.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 104561 ftsZ 1076523 ftsZ Shigella flexneri 2a str. 2457T cell division protein FtsZ NP_835833.1 103410 D 198215 CDS NP_835834.1 30061663 1076524 104662..105579 1 NC_004741.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 105579 lpxC 1076524 lpxC Shigella flexneri 2a str. 2457T UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase NP_835834.1 104662 D 198215 CDS NP_835835.2 161486549 1076525 105810..106322 1 NC_004741.1 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 106322 yacA 1076525 yacA Shigella flexneri 2a str. 2457T SecA regulator SecM NP_835835.2 105810 D 198215 CDS NP_835836.1 30061665 1076526 106384..109089 1 NC_004741.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 109089 secA 1076526 secA Shigella flexneri 2a str. 2457T preprotein translocase subunit SecA NP_835836.1 106384 D 198215 CDS NP_835837.1 30061666 1076527 109149..109538 1 NC_004741.1 residues 1 to 129 of 129 are 98.44 pct identical to residues 1 to 129 of 129 from Escherichia coli K-12 : B0099; prefers dGTP, causes AT-GC transversions; nucleoside triphosphate pyrophosphohydrolase 109538 mutT 1076527 mutT Shigella flexneri 2a str. 2457T nucleoside triphosphate pyrophosphohydrolase NP_835837.1 109149 D 198215 CDS NP_835838.1 30061667 1076529 complement(109553..109687) 1 NC_004741.1 residues 1 to 44 of 44 are 97.72 pct identical to residues 1 to 44 of 44 from Escherichia coli K-12 : B0100; hypothetical protein 109687 1076529 S0099 Shigella flexneri 2a str. 2457T hypothetical protein NP_835838.1 109553 R 198215 CDS NP_835839.1 30061668 1076530 complement(109638..109835) 1 NC_004741.1 residues 1 to 65 of 65 are 100.00 pct identical to residues 1 to 65 of 65 from Escherichia coli K-12 : B0101; zinc-binding protein 109835 yacG 1076530 yacG Shigella flexneri 2a str. 2457T zinc-binding protein NP_835839.1 109638 R 198215 CDS NP_835840.1 30061669 1076531 complement(109845..110588) 1 NC_004741.1 residues 1 to 247 of 247 are 93.52 pct identical to residues 1 to 247 of 247 from Escherichia coli K-12 : B0102; hypothetical protein 110588 yacF 1076531 yacF Shigella flexneri 2a str. 2457T hypothetical protein NP_835840.1 109845 R 198215 CDS NP_835841.1 30061670 1076532 complement(110588..111208) 1 NC_004741.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 111208 coaE 1076532 coaE Shigella flexneri 2a str. 2457T dephospho-CoA kinase NP_835841.1 110588 R 198215 CDS NP_835842.1 30061671 1076533 111433..112476 1 NC_004741.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 112476 guaC 1076533 guaC Shigella flexneri 2a str. 2457T guanosine 5'-monophosphate oxidoreductase NP_835842.1 111433 D 198215 CDS NP_835843.1 30061672 1076534 complement(112396..112503) 1 NC_004741.1 residues 1 to 35 of 35 are 97.14 pct identical to residues 1 to 35 of 35 from Escherichia coli K-12 : B0105; hypothetical protein 112503 1076534 S0104 Shigella flexneri 2a str. 2457T hypothetical protein NP_835843.1 112396 R 198215 CDS NP_835844.1 30061673 1076537 complement(112511..113713) 1 NC_004741.1 residues 1 to 400 of 400 are 85.50 pct identical to residues 1 to 400 of 400 from Escherichia coli K-12 : B0106; involved in biogenesis of fimbriae, protein transport, DNA uptake; type IV pilin biogenesis protein 113713 hofC 1076537 hofC Shigella flexneri 2a str. 2457T type IV pilin biogenesis protein NP_835844.1 112511 R 198215 CDS NP_835845.1 30061674 1076540 complement(114860..115300) 1 NC_004741.1 residues 1 to 146 of 146 are 91.09 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 : B0108; major pilin subunit 115300 ppdD 1076540 ppdD Shigella flexneri 2a str. 2457T major pilin subunit NP_835845.1 114860 R 198215 CDS NP_835846.1 30061675 1076541 complement(115503..116396) 1 NC_004741.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase 116396 nadC 1076541 nadC Shigella flexneri 2a str. 2457T quinolinate phosphoribosyltransferase NP_835846.1 115503 R 198215 CDS NP_835847.1 30061676 1076542 116484..117035 1 NC_004741.1 residues 1 to 183 of 183 are 97.81 pct identical to residues 1 to 183 of 183 from Escherichia coli K-12 : B0110; regulates ampC; N-acetyl-anhydromuranmyl-L-alanine amidase 117035 ampD 1076542 ampD Shigella flexneri 2a str. 2457T N-acetyl-anhydromuranmyl-L-alanine amidase NP_835847.1 116484 D 198215 CDS NP_835848.1 30061677 1076543 117032..117886 1 NC_004741.1 involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 117886 ampE 1076543 ampE Shigella flexneri 2a str. 2457T regulatory protein AmpE NP_835848.1 117032 D 198215 CDS NP_835849.1 30061678 1076544 complement(117929..119302) 1 NC_004741.1 residues 1 to 457 of 457 are 93.65 pct identical to residues 1 to 457 of 457 from Escherichia coli K-12 : B0112; aromatic amino acid transporter 119302 aroP 1076544 aroP Shigella flexneri 2a str. 2457T aromatic amino acid transporter NP_835849.1 117929 R 198215 CDS NP_835850.1 30061679 1076545 119843..120607 1 NC_004741.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 120607 pdhR 1076545 pdhR Shigella flexneri 2a str. 2457T transcriptional regulator PdhR NP_835850.1 119843 D 198215 CDS NP_835851.1 30061680 1076546 120768..123431 1 NC_004741.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 123431 aceE 1076546 aceE Shigella flexneri 2a str. 2457T pyruvate dehydrogenase subunit E1 NP_835851.1 120768 D 198215 CDS NP_835852.1 30061681 1077898 123446..125326 1 NC_004741.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 125326 aceF 1077898 aceF Shigella flexneri 2a str. 2457T dihydrolipoamide acetyltransferase NP_835852.1 123446 D 198215 CDS NP_835853.1 30061682 1076547 125651..127075 1 NC_004741.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 127075 lpdA 1076547 lpdA Shigella flexneri 2a str. 2457T dihydrolipoamide dehydrogenase NP_835853.1 125651 D 198215 CDS NP_835854.1 30061683 1079612 129353..131950 1 NC_004741.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 131950 acnB 1079612 acnB Shigella flexneri 2a str. 2457T bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase NP_835854.1 129353 D 198215 CDS NP_835855.2 161486548 1076549 132125..132487 1 NC_004741.1 residues 1 to 136 of 136 are 98.52 pct identical to residues 1 to 136 of 136 from Escherichia coli K-12 : B0119; hypothetical protein 132487 yacL 1076549 yacL Shigella flexneri 2a str. 2457T hypothetical protein NP_835855.2 132125 D 198215 CDS NP_835856.1 30061685 1080931 complement(132525..133319) 1 NC_004741.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 133319 speD 1080931 speD Shigella flexneri 2a str. 2457T S-adenosylmethionine decarboxylase NP_835856.1 132525 R 198215 CDS NP_835857.1 30061686 1076550 complement(133335..134201) 1 NC_004741.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 134201 speE 1076550 speE Shigella flexneri 2a str. 2457T spermidine synthase NP_835857.1 133335 R 198215 CDS NP_835858.1 30061687 1076551 complement(134307..134777) 1 NC_004741.1 residues 1 to 156 of 156 are 98.71 pct identical to residues 1 to 156 of 156 from Escherichia coli K-12 : B0122; hypothetical protein 134777 yacC 1076551 yacC Shigella flexneri 2a str. 2457T hypothetical protein NP_835858.1 134307 R 198215 CDS NP_835859.1 30061688 1076552 134820..136370 1 NC_004741.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 136370 yacK 1076552 yacK Shigella flexneri 2a str. 2457T multicopper oxidase NP_835859.1 134820 D 198215 CDS NP_835860.1 30061689 1076554 complement(136417..138807) 1 NC_004741.1 residues 1 to 796 of 796 are 93.09 pct identical to residues 1 to 796 of 796 from Escherichia coli K-12 : B0124; glucose dehydrogenase 138807 gcd 1076554 gcd Shigella flexneri 2a str. 2457T glucose dehydrogenase NP_835860.1 136417 R 198215 CDS NP_835861.2 161486547 1076555 139013..139549 1 NC_004741.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 139549 hpt 1076555 hpt Shigella flexneri 2a str. 2457T hypoxanthine-guanine phosphoribosyltransferase NP_835861.2 139013 D 198215 CDS NP_835862.1 30061691 1076556 complement(139590..140252) 1 NC_004741.1 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 140252 yadF 1076556 yadF Shigella flexneri 2a str. 2457T carbonic anhydrase NP_835862.1 139590 R 198215 CDS NP_835863.1 30061692 1076558 140361..141287 1 NC_004741.1 residues 1 to 308 of 308 are 99.67 pct identical to residues 1 to 308 of 308 from Escherichia coli K-12 : B0127; ATP-binding component of a transport system 141287 yadG 1076558 yadG Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_835863.1 140361 D 198215 CDS NP_835864.1 30061693 1076559 141284..142054 1 NC_004741.1 residues 1 to 256 of 256 are 89.06 pct identical to residues 1 to 256 of 256 from Escherichia coli K-12 : B0128; hypothetical protein 142054 yadH 1076559 yadH Shigella flexneri 2a str. 2457T hypothetical protein NP_835864.1 141284 D 198215 CDS NP_835865.1 30061694 1076560 142159..142599 1 NC_004741.1 residues 1 to 146 of 146 are 98.63 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 : B0129; PTS enzyme II B component 142599 yadI 1076560 yadI Shigella flexneri 2a str. 2457T PTS enzyme II B component NP_835865.1 142159 D 198215 CDS NP_835866.1 30061695 1076561 142663..143892 1 NC_004741.1 residues 1 to 409 of 409 are 97.79 pct identical to residues 1 to 409 of 409 from Escherichia coli K-12 : B0130; hypothetical protein 143892 yadE 1076561 yadE Shigella flexneri 2a str. 2457T hypothetical protein NP_835866.1 142663 D 198215 CDS NP_835867.1 30061696 1076562 complement(143896..144276) 1 NC_004741.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 144276 panD 1076562 panD Shigella flexneri 2a str. 2457T aspartate alpha-decarboxylase NP_835867.1 143896 R 198215 CDS NP_835868.1 30061697 1077863 144550..145452 1 NC_004741.1 residues 1 to 300 of 300 are 92.66 pct identical to residues 1 to 300 of 300 from Escherichia coli K-12 : B0132; hypothetical protein 145452 yadD 1077863 yadD Shigella flexneri 2a str. 2457T hypothetical protein NP_835868.1 144550 D 198215 CDS NP_835869.1 30061698 1076563 complement(145526..146377) 1 NC_004741.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 146377 panC 1076563 panC Shigella flexneri 2a str. 2457T pantoate--beta-alanine ligase NP_835869.1 145526 R 198215 CDS NP_835870.1 30061699 1076564 complement(146389..147183) 1 NC_004741.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 147183 panB 1076564 panB Shigella flexneri 2a str. 2457T 3-methyl-2-oxobutanoate hydroxymethyltransferase NP_835870.1 146389 R 198215 CDS NP_835871.1 30061700 1076567 147677..147952 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 147952 1076567 S0134 Shigella flexneri 2a str. 2457T IS1 orfA NP_835871.1 147677 D 198215 CDS NP_835872.1 30061701 1076568 147871..148374 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 148374 1076568 S0136 Shigella flexneri 2a str. 2457T IS1 orfB NP_835872.1 147871 D 198215 CDS NP_835873.1 30061702 1076569 complement(148522..149001) 1 NC_004741.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 149001 folK 1076569 folK Shigella flexneri 2a str. 2457T 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase NP_835873.1 148522 R 198215 CDS NP_835874.2 161486546 1076570 complement(148998..150416) 1 NC_004741.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase I 150416 pcnB 1076570 pcnB Shigella flexneri 2a str. 2457T poly(A) polymerase I NP_835874.2 148998 R 198215 CDS NP_835875.2 161486545 1076573 complement(150455..151351) 1 NC_004741.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 151351 yadB 1076573 yadB Shigella flexneri 2a str. 2457T glutamyl-Q tRNA(Asp) synthetase NP_835875.2 150455 R 198215 CDS NP_835876.1 30061705 1076574 complement(151418..151873) 1 NC_004741.1 residues 1 to 151 of 151 are 90.06 pct identical to residues 1 to 151 of 151 from Escherichia coli K-12 : B0145; DnaK transcriptional regulator DksA 151873 dksA 1076574 dksA Shigella flexneri 2a str. 2457T DnaK transcriptional regulator DksA NP_835876.1 151418 R 198215 CDS NP_835877.1 30061706 1076575 complement(152051..152755) 1 NC_004741.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 152755 sfsA 1076575 sfsA Shigella flexneri 2a str. 2457T sugar fermentation stimulation protein A NP_835877.1 152051 R 198215 CDS NP_835878.1 30061707 1076576 complement(152770..153309) 1 NC_004741.1 residues 1 to 179 of 179 are 99.44 pct identical to residues 1 to 179 of 179 from Escherichia coli K-12 : B0147; hypothetical protein 153309 yadP 1076576 yadP Shigella flexneri 2a str. 2457T hypothetical protein NP_835878.1 152770 R 198215 CDS NP_835879.1 30061708 1076578 153329..155803 1 NC_004741.1 similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 155803 hrpB 1076578 hrpB Shigella flexneri 2a str. 2457T ATP-dependent RNA helicase HrpB NP_835879.1 153329 D 198215 CDS NP_835880.1 30061709 1076579 155999..158533 1 NC_004741.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 158533 mrcB 1076579 mrcB Shigella flexneri 2a str. 2457T penicillin-binding protein 1b NP_835880.1 155999 D 198215 CDS NP_835881.1 30061710 1076580 158753..160996 1 NC_004741.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 160996 fhuA 1076580 fhuA Shigella flexneri 2a str. 2457T ferrichrome outer membrane transporter NP_835881.1 158753 D 198215 CDS NP_835882.1 30061711 1076581 161047..161844 1 NC_004741.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 161844 fhuC 1076581 fhuC Shigella flexneri 2a str. 2457T iron-hydroxamate transporter ATP-binding subunit NP_835882.1 161047 D 198215 CDS NP_835883.1 30061712 1076582 161844..162734 1 NC_004741.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 162734 fhuD 1076582 fhuD Shigella flexneri 2a str. 2457T iron-hydroxamate transporter substrate-binding subunit NP_835883.1 161844 D 198215 CDS NP_835884.1 30061713 1076583 162731..164713 1 NC_004741.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 164713 fhuB 1076583 fhuB Shigella flexneri 2a str. 2457T iron-hydroxamate transporter permease subunit NP_835884.1 162731 D 198215 CDS NP_835885.1 30061714 1076566 complement(164748..166028) 1 NC_004741.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 166028 hemL 1076566 hemL Shigella flexneri 2a str. 2457T glutamate-1-semialdehyde aminotransferase NP_835885.1 164748 R 198215 CDS NP_835886.1 30061715 1076584 166253..167674 1 NC_004741.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 167674 yadQ 1076584 yadQ Shigella flexneri 2a str. 2457T chloride channel protein NP_835886.1 166253 D 198215 CDS NP_835887.1 30061716 1077758 167756..168100 1 NC_004741.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 168100 yadR 1077758 yadR Shigella flexneri 2a str. 2457T iron-sulfur cluster insertion protein ErpA NP_835887.1 167756 D 198215 CDS NP_835888.1 30061717 1076585 complement(168147..168770) 1 NC_004741.1 residues 1 to 207 of 207 are 85.99 pct identical to residues 1 to 207 of 207 from Escherichia coli K-12 : B0157; hypothetical protein 168770 yadS 1076585 yadS Shigella flexneri 2a str. 2457T hypothetical protein NP_835888.1 168147 R 198215 CDS NP_835889.1 30061718 1076586 complement(168808..169608) 1 NC_004741.1 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 169608 yadT 1076586 yadT Shigella flexneri 2a str. 2457T vitamin B12-transporter protein BtuF NP_835889.1 168808 R 198215 CDS NP_835890.1 30061719 1076587 complement(169601..170299) 1 NC_004741.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 170299 pfs 1076587 pfs Shigella flexneri 2a str. 2457T 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase NP_835890.1 169601 R 198215 CDS NP_835891.1 30061720 1076588 170383..171900 1 NC_004741.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 171900 dgt 1076588 dgt Shigella flexneri 2a str. 2457T deoxyguanosinetriphosphate triphosphohydrolase NP_835891.1 170383 D 198215 CDS NP_835892.1 30061721 1076589 172030..173454 1 NC_004741.1 protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 173454 htrA 1076589 htrA Shigella flexneri 2a str. 2457T serine endoprotease NP_835892.1 172030 D 198215 CDS NP_835893.1 30061722 1076591 complement(174854..175240) 1 NC_004741.1 residues 1 to 128 of 128 are 100.00 pct identical to residues 1 to 128 of 128 from Escherichia coli K-12 : B0163; hypothetical protein 175240 yaeH 1076591 yaeH Shigella flexneri 2a str. 2457T hypothetical protein NP_835893.1 174854 R 198215 CDS NP_835894.1 30061723 1076592 complement(175554..176378) 1 NC_004741.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 176378 dapD 1076592 dapD Shigella flexneri 2a str. 2457T 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase NP_835894.1 175554 R 198215 CDS NP_835895.1 30061724 1076593 complement(176409..179081) 1 NC_004741.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 179081 glnD 1076593 glnD Shigella flexneri 2a str. 2457T PII uridylyl-transferase NP_835895.1 176409 R 198215 CDS NP_835896.1 30061725 1076594 complement(179143..179937) 1 NC_004741.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 179937 map 1076594 map Shigella flexneri 2a str. 2457T methionine aminopeptidase NP_835896.1 179143 R 198215 CDS NP_835897.1 30061726 1079387 180305..181030 1 NC_004741.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 181030 rpsB 1079387 rpsB Shigella flexneri 2a str. 2457T 30S ribosomal protein S2 NP_835897.1 180305 D 198215 CDS NP_835898.1 30061727 1076595 181288..182139 1 NC_004741.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 182139 tsf 1076595 tsf Shigella flexneri 2a str. 2457T elongation factor Ts NP_835898.1 181288 D 198215 CDS NP_835899.1 30061728 1076596 182286..183011 1 NC_004741.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 183011 pyrH 1076596 pyrH Shigella flexneri 2a str. 2457T uridylate kinase NP_835899.1 182286 D 198215 CDS NP_835900.1 30061729 1076597 183303..183860 1 NC_004741.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 183860 frr 1076597 frr Shigella flexneri 2a str. 2457T ribosome recycling factor NP_835900.1 183303 D 198215 CDS NP_835901.1 30061730 1076598 183952..185148 1 NC_004741.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 185148 yaeM 1076598 yaeM Shigella flexneri 2a str. 2457T 1-deoxy-D-xylulose 5-phosphate reductoisomerase NP_835901.1 183952 D 198215 CDS NP_835902.1 30061731 1076661 185334..186095 1 NC_004741.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 186095 yaeS 1076661 yaeS Shigella flexneri 2a str. 2457T undecaprenyl pyrophosphate synthase NP_835902.1 185334 D 198215 CDS NP_835903.2 161486544 1076599 186108..186965 1 NC_004741.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 186965 cdsA 1076599 cdsA Shigella flexneri 2a str. 2457T CDP-diglyceride synthase NP_835903.2 186108 D 198215 CDS NP_835904.1 30061733 1079703 186977..188329 1 NC_004741.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 188329 yaeL 1079703 yaeL Shigella flexneri 2a str. 2457T zinc metallopeptidase RseP NP_835904.1 186977 D 198215 CDS NP_835905.1 30061734 1080985 188359..190791 1 NC_004741.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 190791 yaeT 1080985 yaeT Shigella flexneri 2a str. 2457T outer membrane protein assembly factor YaeT NP_835905.1 188359 D 198215 CDS NP_835906.1 30061735 1076600 190913..191398 1 NC_004741.1 residues 1 to 161 of 161 are 89.44 pct identical to residues 1 to 161 of 161 from Escherichia coli K-12 : B0178; located in outer membrane or nucleoid; periplasmic chaperone 191398 hlpA 1076600 hlpA Shigella flexneri 2a str. 2457T periplasmic chaperone NP_835906.1 190913 D 198215 CDS NP_835907.1 30061736 1076601 191402..192427 1 NC_004741.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 192427 lpxD 1076601 lpxD Shigella flexneri 2a str. 2457T UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase NP_835907.1 191402 D 198215 CDS NP_835908.1 30061737 1080987 192532..192987 1 NC_004741.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 192987 fabZ 1080987 fabZ Shigella flexneri 2a str. 2457T (3R)-hydroxymyristoyl-ACP dehydratase NP_835908.1 192532 D 198215 CDS NP_835909.1 30061738 1080989 192991..193779 1 NC_004741.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 193779 lpxA 1080989 lpxA Shigella flexneri 2a str. 2457T UDP-N-acetylglucosamine acyltransferase NP_835909.1 192991 D 198215 CDS NP_835910.1 30061739 1076602 193779..194927 1 NC_004741.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 194927 lpxB 1076602 lpxB Shigella flexneri 2a str. 2457T lipid-A-disaccharide synthase NP_835910.1 193779 D 198215 CDS NP_835911.1 30061740 1076604 194924..195520 1 NC_004741.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 195520 rnhB 1076604 rnhB Shigella flexneri 2a str. 2457T ribonuclease HII NP_835911.1 194924 D 198215 CDS NP_835912.1 30061741 1076605 195557..199039 1 NC_004741.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 199039 dnaE 1076605 dnaE Shigella flexneri 2a str. 2457T DNA polymerase III subunit alpha NP_835912.1 195557 D 198215 CDS NP_835913.1 30061742 1076606 199052..200011 1 NC_004741.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 200011 accA 1076606 accA Shigella flexneri 2a str. 2457T acetyl-CoA carboxylase carboxyltransferase subunit alpha NP_835913.1 199052 D 198215 CDS NP_835914.1 30061743 1076607 200110..202251 1 NC_004741.1 residues 1 to 713 of 713 are 99.15 pct identical to residues 1 to 713 of 713 from Escherichia coli K-12 : B0186; lysine decarboxylase 2 202251 ldcC 1076607 ldcC Shigella flexneri 2a str. 2457T lysine decarboxylase 2 NP_835914.1 200110 D 198215 CDS NP_835915.2 161486543 1079983 202308..202697 1 NC_004741.1 residues 1 to 138 of 138 are 89.13 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 : B0187; hypothetical protein 202697 yaeR 1079983 yaeR Shigella flexneri 2a str. 2457T hypothetical protein NP_835915.2 202308 D 198215 CDS NP_835916.1 30061745 1076608 202762..204060 1 NC_004741.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 204060 tilS 1076608 tilS Shigella flexneri 2a str. 2457T tRNA(Ile)-lysidine synthetase NP_835916.1 202762 D 198215 CDS NP_835917.1 30061746 1076609 complement(204109..204369) 1 NC_004741.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 204369 yaeO 1076609 yaeO Shigella flexneri 2a str. 2457T Rho-binding antiterminator NP_835917.1 204109 R 198215 CDS NP_835918.1 30061747 1076610 204722..205267 1 NC_004741.1 residues 1 to 181 of 181 are 100.00 pct identical to residues 1 to 181 of 181 from Escherichia coli K-12 : B0190; hypothetical protein 205267 yaeQ 1076610 yaeQ Shigella flexneri 2a str. 2457T hypothetical protein NP_835918.1 204722 D 198215 CDS NP_835919.1 30061748 1076611 205264..205686 1 NC_004741.1 residues 1 to 140 of 140 are 97.14 pct identical to residues 1 to 140 of 140 from Escherichia coli K-12 : B0191; peptidyl-tRNA hydrolase domain protein 205686 yaeJ 1076611 yaeJ Shigella flexneri 2a str. 2457T peptidyl-tRNA hydrolase domain protein NP_835919.1 205264 D 198215 CDS NP_835920.1 30061749 1076612 205700..206410 1 NC_004741.1 residues 1 to 236 of 236 are 98.30 pct identical to residues 1 to 236 of 236 from Escherichia coli K-12 : B0192; lipoprotein involved with copper homeostasis and adhesion 206410 cutF 1076612 cutF Shigella flexneri 2a str. 2457T lipoprotein involved with copper homeostasis and adhesion NP_835920.1 205700 D 198215 CDS NP_835921.1 30061750 1076613 complement(206565..207389) 1 NC_004741.1 residues 1 to 274 of 274 are 94.89 pct identical to residues 19 to 292 of 292 from Escherichia coli K-12 : B0193; hypothetical protein 207389 yaeF 1076613 yaeF Shigella flexneri 2a str. 2457T hypothetical protein NP_835921.1 206565 R 198215 CDS NP_835922.1 30061751 1076614 complement(207442..209160) 1 NC_004741.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 209160 proS 1076614 proS Shigella flexneri 2a str. 2457T prolyl-tRNA synthetase NP_835922.1 207442 R 198215 CDS NP_835923.1 30061752 1076615 complement(209271..209978) 1 NC_004741.1 residues 1 to 235 of 235 are 92.76 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B0195; hypothetical protein 209978 yaeB 1076615 yaeB Shigella flexneri 2a str. 2457T hypothetical protein NP_835923.1 209271 R 198215 CDS NP_835924.1 30061753 1076617 complement(209975..210379) 1 NC_004741.1 residues 1 to 134 of 134 are 85.82 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B0196; involved in colanic acid synthesis; interacts with RcsB; outer membrane lipoprotein 210379 rcsF 1076617 rcsF Shigella flexneri 2a str. 2457T outer membrane lipoprotein NP_835924.1 209975 R 198215 CDS NP_835925.1 30061754 1076620 complement(210497..211312) 1 NC_004741.1 residues 1 to 271 of 271 are 94.83 pct identical to residues 1 to 271 of 271 from Escherichia coli K-12 : B0197; DL-methionine transporter substrate-binding subunit 211312 metQ 1076620 metQ Shigella flexneri 2a str. 2457T DL-methionine transporter substrate-binding subunit NP_835925.1 210497 R 198215 CDS NP_835926.1 30061755 1076622 complement(211352..212005) 1 NC_004741.1 part of the MetNIQ methionine uptake system; DL-methionine transporter permease subunit 212005 yaeE 1076622 yaeE Shigella flexneri 2a str. 2457T DL-methionine transporter permease subunit NP_835926.1 211352 R 198215 CDS NP_835927.1 30061756 1077808 complement(211998..213029) 1 NC_004741.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 213029 metN 1077808 metN Shigella flexneri 2a str. 2457T DL-methionine transporter ATP-binding subunit NP_835927.1 211998 R 198215 CDS NP_835928.1 30061757 1076623 213217..213792 1 NC_004741.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 213792 yaeD 1076623 yaeD Shigella flexneri 2a str. 2457T D,D-heptose 1,7-bisphosphate phosphatase NP_835928.1 213217 D 198215 CDS NP_835929.1 30061758 1076632 219551..220354 1 NC_004741.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 220354 dkgB 1076632 dkgB Shigella flexneri 2a str. 2457T 2,5-diketo-D-gluconate reductase B NP_835929.1 219551 D 198215 CDS NP_835930.1 30061759 1078798 complement(220393..221721) 1 NC_004741.1 residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 221721 1078798 S0201 Shigella flexneri 2a str. 2457T IS4 orf NP_835930.1 220393 R 198215 CDS NP_835931.1 30061760 1076633 complement(221789..222703) 1 NC_004741.1 residues 1 to 301 of 304 are 98.67 pct identical to residues 1 to 301 of 304 from Escherichia coli K-12 : B0208; transcriptional regulator LYSR-type 222703 yafC 1076633 yafC Shigella flexneri 2a str. 2457T transcriptional regulator LYSR-type NP_835931.1 221789 R 198215 CDS NP_835932.1 30061761 1076636 222944..223744 1 NC_004741.1 residues 1 to 266 of 266 are 100.00 pct identical to residues 1 to 266 of 266 from Escherichia coli K-12 : B0209; hypothetical protein 223744 yafD 1076636 yafD Shigella flexneri 2a str. 2457T hypothetical protein NP_835932.1 222944 D 198215 CDS NP_835933.1 30061762 1078831 223972..224592 1 NC_004741.1 residues 2 to 206 of 206 are 93.65 pct identical to residues 3 to 207 of 207 from Escherichia coli K-12 : B0210; biotin synthesis protein 224592 yafE 1078831 yafE Shigella flexneri 2a str. 2457T biotin synthesis protein NP_835933.1 223972 D 198215 CDS NP_835934.1 30061763 1076635 complement(224640..225986) 1 NC_004741.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 225986 mltD 1076635 mltD Shigella flexneri 2a str. 2457T membrane-bound lytic murein transglycosylase D NP_835934.1 224640 R 198215 CDS NP_835935.1 30061764 1076639 complement(226058..226813) 1 NC_004741.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 226813 gloB 1076639 gloB Shigella flexneri 2a str. 2457T hydroxyacylglutathione hydrolase NP_835935.1 226058 R 198215 CDS NP_835936.1 30061765 1076640 226844..227569 1 NC_004741.1 residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B0213; hypothetical protein 227569 yafS 1076640 yafS Shigella flexneri 2a str. 2457T hypothetical protein NP_835936.1 226844 D 198215 CDS NP_835937.1 30061766 1078814 complement(227566..228033) 1 NC_004741.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 228033 rnhA 1078814 rnhA Shigella flexneri 2a str. 2457T ribonuclease H NP_835937.1 227566 R 198215 CDS NP_835938.1 30061767 1076650 228098..228829 1 NC_004741.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 228829 dnaQ 1076650 dnaQ Shigella flexneri 2a str. 2457T DNA polymerase III subunit epsilon NP_835938.1 228098 D 198215 CDS NP_835939.1 30061768 1078803 complement(229169..230215) 1 NC_004741.1 residues 1 to 348 of 348 are 68.66 pct identical to residues 1 to 351 of 351 from GenPept : >gb|AAL19222.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein 230215 safA 1078803 safA Shigella flexneri 2a str. 2457T hypothetical protein NP_835939.1 229169 R 198215 CDS NP_835940.1 30061769 1080072 complement(230226..230339) 1 NC_004741.1 residues 1 to 37 of 37 are 86.48 pct identical to residues 154 to 190 of 331 from GenPept : >gb|AAL19223.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein 230339 1080072 S0212 Shigella flexneri 2a str. 2457T hypothetical protein NP_835940.1 230226 R 198215 CDS NP_835941.1 30061770 1076643 complement(230483..230788) 1 NC_004741.1 residues 1 to 100 of 101 are 79.00 pct identical to residues 1 to 100 of 331 from GenPept : >gb|AAL19223.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; periplasmic chaperone of fimbral assembly machinery 230788 safB 1076643 safB Shigella flexneri 2a str. 2457T periplasmic chaperone of fimbral assembly machinery NP_835941.1 230483 R 198215 CDS NP_835942.1 30061771 1076644 complement(230785..232668) 1 NC_004741.1 residues 1 to 627 of 627 are 91.54 pct identical to residues 1 to 627 of 627 from GenPept : >gb|AAL19224.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; outer membrane usher protein 232668 safC 1076644 safC Shigella flexneri 2a str. 2457T outer membrane usher protein NP_835942.1 230785 R 198215 CDS NP_835943.1 30061772 1076651 complement(232684..233178) 1 NC_004741.1 residues 1 to 164 of 164 are 78.65 pct identical to residues 1 to 164 of 164 from GenPept : >emb|CAD08723.1| (AL627266) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 233178 1076651 S0215 Shigella flexneri 2a str. 2457T hypothetical protein NP_835943.1 232684 R 198215 CDS NP_835944.1 30061773 1076652 complement(233373..234005) 1 NC_004741.1 residues 1 to 210 of 210 are 69.99 pct identical to residues 1 to 208 of 274 from GenPept : >gb|AAL19226.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein 234005 sat1 1076652 sat1 Shigella flexneri 2a str. 2457T hypothetical protein NP_835944.1 233373 R 198215 CDS NP_835945.1 30061774 1078828 complement(233992..234369) 1 NC_004741.1 residues 6 to 124 of 125 are 56.66 pct identical to residues 180 to 299 of 300 from GenPept : >gb|AAL19227.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein 234369 sat2 1078828 sat2 Shigella flexneri 2a str. 2457T hypothetical protein NP_835945.1 233992 R 198215 CDS NP_835946.1 30061775 1076634 complement(234607..234906) 1 NC_004741.1 residues 7 to 99 of 99 are 61.29 pct identical to residues 6 to 97 of 300 from GenPept : >gb|AAL19227.1| (AE008707) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein 234906 1076634 S0219 Shigella flexneri 2a str. 2457T hypothetical protein NP_835946.1 234607 R 198215 CDS NP_835947.1 30061776 1076654 234959..235369 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 235369 1076654 S0220 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_835947.1 234959 D 198215 CDS NP_835948.1 30061777 1076656 235327..236232 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 236232 1076656 S0221 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_835948.1 235327 D 198215 CDS NP_835949.1 30061778 1076657 236654..236956 1 NC_004741.1 residues 1 to 100 of 100 are 99.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 236956 1076657 S0223 Shigella flexneri 2a str. 2457T IS911 orfA NP_835949.1 236654 D 198215 CDS NP_835950.1 30061779 1076660 236983..237822 1 NC_004741.1 residues 19 to 297 of 297 are 99.28 pct identical to residues 1 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; IS911 orfB 237822 1076660 S0224 Shigella flexneri 2a str. 2457T IS911 orfB NP_835950.1 236983 D 198215 CDS NP_835952.1 30061781 1076663 complement(238511..238780) 1 NC_004741.1 residues 1 to 89 of 89 are 96.62 pct identical to residues 89 to 177 of 177 from GenPept : >gb|AAC74627.1| (AE000252) lysozyme [Escherichia coli K12]; endolysin R of prophage CP-933V 238780 1076663 S0229 Shigella flexneri 2a str. 2457T endolysin R of prophage CP-933V NP_835952.1 238511 R 198215 CDS NP_835953.1 30061782 1078781 complement(239101..239415) 1 NC_004741.1 residues 1 to 99 of 104 are 64.64 pct identical to residues 1 to 93 of 103 from GenPept : >gb|AAC74628.1| (AE000252) orf, hypothetical protein [Escherichia coli K12]; hypothetical protein 239415 1078781 S0230 Shigella flexneri 2a str. 2457T hypothetical protein NP_835953.1 239101 R 198215 CDS NP_835954.1 30061783 1078780 complement(239420..239635) 1 NC_004741.1 residues 1 to 71 of 71 are 97.18 pct identical to residues 1 to 71 of 71 from GenPept : >gb|AAA32349.1| (M65239) S [Bacteriophage 21]; lysis protein S 239635 1078780 S0231 Shigella flexneri 2a str. 2457T lysis protein S NP_835954.1 239420 R 198215 CDS NP_835955.1 30061784 1076666 239992..240366 1 NC_004741.1 no significant similarities; hypothetical protein 240366 1076666 S0232 Shigella flexneri 2a str. 2457T hypothetical protein NP_835955.1 239992 D 198215 CDS NP_835956.1 30061785 1076668 complement(240390..240797) 1 NC_004741.1 residues 7 to 126 of 135 are 29.83 pct identical to residues 203 to 324 of 327 from GenPept : >emb|CAD02863.1| (AL627277) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 240797 1076668 S0233 Shigella flexneri 2a str. 2457T hypothetical protein NP_835956.1 240390 R 198215 CDS NP_835957.1 30061786 1076665 complement(240794..241846) 1 NC_004741.1 residues 72 to 350 of 350 are 99.64 pct identical to residues 1 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; IS911 orfA 241846 1076665 S0235 Shigella flexneri 2a str. 2457T IS911 orfA NP_835957.1 240794 R 198215 CDS NP_835958.1 30061787 1076669 complement(240794..241633) 1 NC_004741.1 residues 19 to 297 of 297 are 99.64 pct identical to residues 1 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; IS911 orfB 241633 1076669 S0234 Shigella flexneri 2a str. 2457T IS911 orfB NP_835958.1 240794 R 198215 CDS NP_835959.1 30061788 1078818 242170..242730 1 NC_004741.1 residues 1 to 184 of 186 are 89.67 pct identical to residues 200 to 383 of 499 from GenPept : >gb|AAF75044.1| (AF217253) terminase large subunit [Enterobacteria phage P22]; terminase large subunit 242730 1078818 S0236 Shigella flexneri 2a str. 2457T terminase large subunit NP_835959.1 242170 D 198215 CDS NP_835960.1 30061789 1076681 242699..243073 1 NC_004741.1 residues 7 to 99 of 124 are 82.79 pct identical to residues 382 to 474 of 499 from GenPept : >gb|AAF75044.1| (AF217253) terminase large subunit [Enterobacteria phage P22]; terminase large subunit 243073 1076681 S0237 Shigella flexneri 2a str. 2457T terminase large subunit NP_835960.1 242699 D 198215 CDS NP_835961.1 30061790 1076671 243074..245239 1 NC_004741.1 residues 1 to 721 of 721 are 72.48 pct identical to residues 1 to 725 of 725 from GenPept : >gb|AAF75045.1| (AF217253) portal protein [Enterobacteria phage P22]; packaging glycoprotein 245239 1076671 S0238 Shigella flexneri 2a str. 2457T packaging glycoprotein NP_835961.1 243074 D 198215 CDS NP_835962.1 30061791 1076672 245253..246164 1 NC_004741.1 residues 1 to 303 of 303 are 79.27 pct identical to residues 1 to 303 of 303 from GenPept : >gb|AAF75046.1| (AF217253) scaffolding protein [Enterobacteria phage P22]; scaffolding protein 246164 1076672 S0239 Shigella flexneri 2a str. 2457T scaffolding protein NP_835962.1 245253 D 198215 CDS NP_835963.1 30061792 1076673 246164..247459 1 NC_004741.1 residues 1 to 431 of 431 are 72.62 pct identical to residues 1 to 430 of 430 from GenPept : >gb|AAF75047.1| (AF217253) coat protein [Enterobacteria phage P22]; coat protein 247459 1076673 S0240 Shigella flexneri 2a str. 2457T coat protein NP_835963.1 246164 D 198215 CDS NP_835964.1 30061793 1078862 247504..247734 1 NC_004741.1 no significant similarities; hypothetical protein 247734 1078862 S0241 Shigella flexneri 2a str. 2457T hypothetical protein NP_835964.1 247504 D 198215 CDS NP_835965.1 30061794 1076695 247712..248212 1 NC_004741.1 residues 1 to 163 of 166 are 60.12 pct identical to residues 1 to 157 of 166 from GenPept : >gb|AAF75049.1| (AF217253) DNA stabilization protein [Enterobacteria phage P22]; DNA stabilization protein 248212 1076695 S0242 Shigella flexneri 2a str. 2457T DNA stabilization protein NP_835965.1 247712 D 198215 CDS NP_835966.1 30061795 1076674 248212..249630 1 NC_004741.1 residues 1 to 472 of 472 are 98.72 pct identical to residues 1 to 472 of 472 from GenPept : >gb|AAK28897.1|AF335538_49 (AF335538) DNA stabilization protein [Bacteriophage HK620]; packaged DNA stabilization protein 249630 1076674 S0243 Shigella flexneri 2a str. 2457T packaged DNA stabilization protein NP_835966.1 248212 D 198215 CDS NP_835967.1 30061796 1080087 249630..250478 1 NC_004741.1 residues 96 to 282 of 282 are 87.16 pct identical to residues 3 to 189 of 189 from GenPept : >gb|AAG57480.1|AE005466_10 (AE005466) Z3617 gene product [Escherichia coli O157:H7 EDL933]; packaged DNA stabilization protein 250478 1080087 S0244 Shigella flexneri 2a str. 2457T packaged DNA stabilization protein NP_835967.1 249630 D 198215 CDS NP_835968.1 30061797 1078779 250478..250933 1 NC_004741.1 residues 1 to 151 of 151 are 98.67 pct identical to residues 1 to 151 of 151 from GenPept : >gb|AAK28899.1|AF335538_51 (AF335538) head assembly protein [Bacteriophage HK620]; head assembly protein 250933 1078779 S0245 Shigella flexneri 2a str. 2457T head assembly protein NP_835968.1 250478 D 198215 CDS NP_835969.1 30061798 1076675 250936..251628 1 NC_004741.1 residues 1 to 230 of 230 are 52.60 pct identical to residues 1 to 230 of 230 from GenPept : >gb|AAK28900.1|AF335538_52 (AF335538) DNA transfer protein [Bacteriophage HK620]; DNA transfer protein 251628 1076675 S0246 Shigella flexneri 2a str. 2457T DNA transfer protein NP_835969.1 250936 D 198215 CDS NP_835970.1 30061799 1076677 251638..252969 1 NC_004741.1 residues 1 to 216 of 443 are 57.79 pct identical to residues 1 to 215 of 378 from GenPept : >gb|AAG57477.1|AE005466_7 (AE005466) prophage DNA injection protein [Escherichia coli O157:H7 EDL933]; prophage DNA injection protein 252969 1076677 S0247 Shigella flexneri 2a str. 2457T prophage DNA injection protein NP_835970.1 251638 D 198215 CDS NP_835971.1 30061800 1076678 252970..254700 1 NC_004741.1 residues 217 to 348 of 576 are 76.35 pct identical to residues 60 to 207 of 722 from GenPept : >gb|AAK28902.1|AF335538_54 (AF335538) DNA transfer protein [Bacteriophage HK620]; DNA transfer protein 254700 1076678 S0248 Shigella flexneri 2a str. 2457T DNA transfer protein NP_835971.1 252970 D 198215 CDS NP_835972.1 30061801 1076679 254826..255152 1 NC_004741.1 residues 1 to 108 of 108 are 74.07 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72412.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA 255152 1076679 S0249 Shigella flexneri 2a str. 2457T IS629 orfA NP_835972.1 254826 D 198215 CDS NP_835973.1 30061802 1076680 255387..256034 1 NC_004741.1 residues 1 to 215 of 215 are 98.13 pct identical to residues 8 to 222 of 222 from GenPept : >gb|AAL72361.1| (AF386526) transposase [Shigella flexneri 2a]; IS629 orfB 256034 1076680 S0250 Shigella flexneri 2a str. 2457T IS629 orfB NP_835973.1 255387 D 198215 CDS NP_835974.1 30061803 1076683 complement(256085..256423) 1 NC_004741.1 residues 1 to 112 of 112 are 83.92 pct identical to residues 1 to 112 of 112 from Escherichia coli K-12 : B0384; hypothetical protein 256423 psiF 1076683 psiF Shigella flexneri 2a str. 2457T hypothetical protein NP_835974.1 256085 R 198215 CDS NP_835975.1 30061804 1076684 complement(256524..258008) 1 NC_004741.1 residues 1 to 487 of 487 are 96.71 pct identical to residues 8 to 494 of 494 from Escherichia coli K-12 : B0383; alkaline phosphatase 258008 phoA 1076684 phoA Shigella flexneri 2a str. 2457T alkaline phosphatase NP_835975.1 256524 R 198215 CDS NP_835976.1 30061805 1076685 complement(258040..258300) 1 NC_004741.1 residues 1 to 86 of 86 are 98.83 pct identical to residues 1 to 86 of 86 from Escherichia coli K-12 : B0382; hypothetical protein 258300 yaiB 1076685 yaiB Shigella flexneri 2a str. 2457T hypothetical protein NP_835976.1 258040 R 198215 CDS NP_835977.1 30061806 1076687 258763..259857 1 NC_004741.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 259857 ddl 1076687 ddl Shigella flexneri 2a str. 2457T D-alanyl-alanine synthetase A NP_835977.1 258763 D 198215 CDS NP_835978.1 30061807 1076688 complement(259881..260225) 1 NC_004741.1 residues 1 to 114 of 114 are 97.36 pct identical to residues 1 to 114 of 114 from Escherichia coli K-12 : B0380; hypothetical protein 260225 1076688 S0255 Shigella flexneri 2a str. 2457T hypothetical protein NP_835978.1 259881 R 198215 CDS NP_835979.1 30061808 1076689 260353..260661 1 NC_004741.1 residues 1 to 102 of 102 are 99.01 pct identical to residues 1 to 102 of 102 from Escherichia coli K-12 : B0379; hypothetical protein 260661 1076689 S0256 Shigella flexneri 2a str. 2457T hypothetical protein NP_835979.1 260353 D 198215 CDS NP_835980.1 30061809 1076690 complement(260720..261814) 1 NC_004741.1 residues 1 to 364 of 364 are 95.05 pct identical to residues 1 to 364 of 364 from Escherichia coli K-12 : B0378; hypothetical protein 261814 yaiW 1076690 yaiW Shigella flexneri 2a str. 2457T hypothetical protein NP_835980.1 260720 R 198215 CDS NP_835981.1 30061810 1076691 complement(261827..263047) 1 NC_004741.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transporter 263047 sbmA 1076691 sbmA Shigella flexneri 2a str. 2457T transporter NP_835981.1 261827 R 198215 CDS NP_835982.1 30061811 1076692 263399..264556 1 NC_004741.1 this protein has no known enzymatic function; beta-lactam binding protein AmpH 264556 yaiH 1076692 yaiH Shigella flexneri 2a str. 2457T beta-lactam binding protein AmpH NP_835982.1 263399 D 198215 CDS NP_835983.1 30061812 1076696 complement(265695..266507) 1 NC_004741.1 residues 1 to 270 of 270 are 95.92 pct identical to residues 10 to 279 of 279 from GenPept : >gb|AAG53988.1|AF327445_2 (AF327445) transposase B [Pantoea agglomerans]; ISEhe3 orfB 266507 1076696 S0262 Shigella flexneri 2a str. 2457T ISEhe3 orfB NP_835983.1 265695 R 198215 CDS NP_835984.1 30061813 1077596 complement(266781..267494) 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 267494 1077596 S0263 Shigella flexneri 2a str. 2457T IS600 orfB NP_835984.1 266781 R 198215 CDS NP_835985.1 30061814 1077611 complement(267635..267937) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 267937 is600a 1077611 is600a Shigella flexneri 2a str. 2457T IS600 orfA NP_835985.1 267635 R 198215 CDS NP_835986.2 161486542 1077812 complement(268714..269619) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 269619 yi22_6 1077812 yi22_6 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_835986.2 268714 R 198215 CDS NP_835987.2 161486541 1076699 complement(269577..269942) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 269942 yi21_6 1076699 yi21_6 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_835987.2 269577 R 198215 CDS NP_835988.1 30061817 1076700 270487..270756 1 NC_004741.1 residues 1 to 89 of 89 are 80.89 pct identical to residues 1 to 89 of 89 from Escherichia coli K-12 : B0370; hypothetical protein 270756 1076700 S0269 Shigella flexneri 2a str. 2457T hypothetical protein NP_835988.1 270487 D 198215 CDS NP_835989.1 30061818 1076701 270893..271900 1 NC_004741.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 271900 hemB 1076701 hemB Shigella flexneri 2a str. 2457T delta-aminolevulinic acid dehydratase NP_835989.1 270893 D 198215 CDS NP_835990.1 30061819 1076702 complement(272006..272857) 1 NC_004741.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 272857 tauD 1076702 tauD Shigella flexneri 2a str. 2457T taurine dioxygenase NP_835990.1 272006 R 198215 CDS NP_835991.1 30061820 1077158 complement(272854..273681) 1 NC_004741.1 residues 1 to 275 of 275 are 90.54 pct identical to residues 1 to 275 of 275 from Escherichia coli K-12 : B0367; taurine transporter subunit 273681 tauC 1077158 tauC Shigella flexneri 2a str. 2457T taurine transporter subunit NP_835991.1 272854 R 198215 CDS NP_835992.1 30061821 1076703 complement(273678..274445) 1 NC_004741.1 Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 274445 tauB 1076703 tauB Shigella flexneri 2a str. 2457T taurine transporter ATP-binding subunit NP_835992.1 273678 R 198215 CDS NP_835993.1 30061822 1076704 complement(274458..275354) 1 NC_004741.1 with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 275354 tauA 1076704 tauA Shigella flexneri 2a str. 2457T taurine transporter substrate binding subunit NP_835993.1 274458 R 198215 CDS NP_835994.1 30061823 1076705 complement(275912..276415) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 276415 1076705 S0275 Shigella flexneri 2a str. 2457T IS1 orfB NP_835994.1 275912 R 198215 CDS NP_835995.1 30061824 1076706 complement(276334..276609) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 276609 1076706 S0276 Shigella flexneri 2a str. 2457T IS1 orfA NP_835995.1 276334 R 198215 CDS NP_835996.1 30061825 1076707 276754..277422 1 NC_004741.1 residues 1 to 222 of 222 are 97.29 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 : B0310; hypothetical protein 277422 ykgH 1076707 ykgH Shigella flexneri 2a str. 2457T hypothetical protein NP_835996.1 276754 D 198215 CDS NP_835997.1 30061826 1076709 277498..277710 1 NC_004741.1 residues 1 to 70 of 70 are 72.85 pct identical to residues 1 to 70 of 70 from Escherichia coli K-12 : B0309; hypothetical protein 277710 1076709 S0278 Shigella flexneri 2a str. 2457T hypothetical protein NP_835997.1 277498 D 198215 CDS NP_835998.2 161486540 1076710 complement(277665..278360) 1 NC_004741.1 residues 1 to 280 of 280 are 94.64 pct identical to residues 3 to 282 of 282 from Escherichia coli K-12 : B0308; transporter 278360 ykgG 1076710 ykgG Shigella flexneri 2a str. 2457T transporter NP_835998.2 277665 R 198215 CDS NP_835999.1 30061828 1076711 complement(278353..279780) 1 NC_004741.1 residues 1 to 475 of 475 are 99.36 pct identical to residues 1 to 475 of 475 from Escherichia coli K-12 : B0307; hypothetical protein 279780 ykgF 1076711 ykgF Shigella flexneri 2a str. 2457T hypothetical protein NP_835999.1 278353 R 198215 CDS NP_836000.1 30061829 1076712 complement(279791..280510) 1 NC_004741.1 residues 1 to 239 of 239 are 98.74 pct identical to residues 1 to 239 of 239 from Escherichia coli K-12 : B0306; dehydrogenase subunit 280510 ykgE 1076712 ykgE Shigella flexneri 2a str. 2457T dehydrogenase subunit NP_836000.1 279791 R 198215 CDS NP_836001.1 30061830 1076697 280929..281204 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 281204 1076697 S0282 Shigella flexneri 2a str. 2457T IS1 orfA NP_836001.1 280929 D 198215 CDS NP_836002.1 30061831 1076713 281123..281626 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 281626 1076713 S0283 Shigella flexneri 2a str. 2457T IS1 orfB NP_836002.1 281123 D 198215 CDS NP_836003.1 30061832 1076714 282704..284917 1 NC_004741.1 residues 1 to 734 of 737 are 80.92 pct identical to residues 1 to 729 of 729 from GenPept : >emb|CAD08749.1| (AL627266) Rhs-family protein [Salmonella enterica subsp. enterica serovar Typhi]; Rhs-family protein 284917 rhsG 1076714 rhsG Shigella flexneri 2a str. 2457T Rhs-family protein NP_836003.1 282704 D 198215 CDS NP_836004.1 30061833 1076715 284940..285140 1 NC_004741.1 residues 5 to 64 of 66 are 78.33 pct identical to residues 5 to 64 of 148 from GenPept : >gb|AAL19247.1| (AE008708) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein 285140 1076715 S0285 Shigella flexneri 2a str. 2457T hypothetical protein NP_836004.1 284940 D 198215 CDS NP_836005.1 30061834 1076716 285197..285385 1 NC_004741.1 residues 1 to 62 of 62 are 67.74 pct identical to residues 86 to 147 of 148 from GenPept : >gb|AAL19247.1| (AE008708) cytoplasmic protein [Salmonella typhimurium LT2]; hypothetical protein 285385 1076716 S0286 Shigella flexneri 2a str. 2457T hypothetical protein NP_836005.1 285197 D 198215 CDS NP_836006.1 30061835 1076717 285407..285814 1 NC_004741.1 residues 1 to 127 of 135 are 68.50 pct identical to residues 1 to 127 of 1354 from GenPept : >emb|CAD08751.1| (AL627266) Rhs-family protein [Salmonella enterica subsp. enterica serovar Typhi]; Rhs-family protein 285814 1076717 S0287 Shigella flexneri 2a str. 2457T Rhs-family protein NP_836006.1 285407 D 198215 CDS NP_836007.1 30061836 1076718 285811..288099 1 NC_004741.1 residues 1 to 759 of 762 are 69.22 pct identical to residues 137 to 954 of 1364 from GenPept : >gb|AAL19248.1| (AE008708) RHS-family protein [Salmonella typhimurium LT2]; Rhs-family protein 288099 rhsD 1076718 rhsD Shigella flexneri 2a str. 2457T Rhs-family protein NP_836007.1 285811 D 198215 CDS NP_836008.1 30061837 1076719 288096..289085 1 NC_004741.1 residues 1 to 291 of 329 are 78.76 pct identical to residues 961 to 1252 of 1354 from GenPept : >emb|CAD08751.1| (AL627266) Rhs-family protein [Salmonella enterica subsp. enterica serovar Typhi]; Rhs-family protein 289085 rhs-like 1076719 rhs-like Shigella flexneri 2a str. 2457T Rhs-family protein NP_836008.1 288096 D 198215 CDS NP_836009.1 30061838 1076720 complement(290134..290904) 1 NC_004741.1 residues 1 to 256 of 256 are 98.04 pct identical to residues 1 to 256 of 256 from Escherichia coli K-12 : B0219; hypothetical protein 290904 yafV 1076720 yafV Shigella flexneri 2a str. 2457T hypothetical protein NP_836009.1 290134 R 198215 CDS NP_836010.1 30061839 1076721 291058..291531 1 NC_004741.1 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 291531 ykfE 1076721 ykfE Shigella flexneri 2a str. 2457T C-lysozyme inhibitor NP_836010.1 291058 D 198215 CDS NP_836011.2 161486539 1076722 complement(291574..294018) 1 NC_004741.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 294018 fadE 1076722 fadE Shigella flexneri 2a str. 2457T acyl-CoA dehydrogenase NP_836011.2 291574 R 198215 CDS NP_836012.1 30061841 1076723 294258..294836 1 NC_004741.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 294836 gmhA 1076723 gmhA Shigella flexneri 2a str. 2457T phosphoheptose isomerase NP_836012.1 294258 D 198215 CDS NP_836013.1 30061842 1076724 295042..295809 1 NC_004741.1 residues 1 to 255 of 255 are 99.60 pct identical to residues 1 to 255 of 255 from Escherichia coli K-12 : B0223; amidotransferase 295809 yafJ 1076724 yafJ Shigella flexneri 2a str. 2457T amidotransferase NP_836013.1 295042 D 198215 CDS NP_836014.1 30061843 1076725 complement(295780..296520) 1 NC_004741.1 residues 1 to 246 of 246 are 99.59 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B0224; hypothetical protein 296520 yafK 1076725 yafK Shigella flexneri 2a str. 2457T hypothetical protein NP_836014.1 295780 R 198215 CDS NP_836015.1 30061844 1076726 296871..297425 1 NC_004741.1 residues 10 to 184 of 184 are 96.57 pct identical to residues 75 to 249 of 249 from Escherichia coli K-12 : B0227; lipoprotein 297425 yafL 1076726 yafL Shigella flexneri 2a str. 2457T lipoprotein NP_836015.1 296871 D 198215 CDS NP_836016.1 30061845 1076728 297601..298098 1 NC_004741.1 residues 1 to 164 of 165 are 94.51 pct identical to residues 1 to 164 of 165 from Escherichia coli K-12 : B0228; hypothetical protein 298098 yafM 1076728 yafM Shigella flexneri 2a str. 2457T hypothetical protein NP_836016.1 297601 D 198215 CDS NP_836017.1 30061846 1080038 complement(298315..300054) 1 NC_004741.1 residues 1 to 579 of 579 are 89.81 pct identical to residues 1 to 579 of 579 from Escherichia coli K-12 : B0229; flagellar biosynthetic protein FlhA 300054 fhiA 1080038 fhiA Shigella flexneri 2a str. 2457T flagellar biosynthetic protein FlhA NP_836017.1 298315 R 198215 CDS NP_836018.1 30061847 1076729 299999..300784 1 NC_004741.1 residues 1 to 261 of 261 are 98.46 pct identical to residues 1 to 261 of 261 from Escherichia coli K-12 : B0230; hypothetical protein 300784 mbhA 1076729 mbhA Shigella flexneri 2a str. 2457T hypothetical protein NP_836018.1 299999 D 198215 CDS NP_836019.1 30061848 1076730 300855..301910 1 NC_004741.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 301910 dinP 1076730 dinP Shigella flexneri 2a str. 2457T DNA polymerase IV NP_836019.1 300855 D 198215 CDS NP_836020.1 30061849 1076731 301962..302255 1 NC_004741.1 residues 1 to 97 of 97 are 98.96 pct identical to residues 1 to 97 of 97 from Escherichia coli K-12 : B0232; antitoxin of the YafO-YafN toxin-antitoxin system 302255 yafN 1076731 yafN Shigella flexneri 2a str. 2457T antitoxin of the YafO-YafN toxin-antitoxin system NP_836020.1 301962 D 198215 CDS NP_836021.1 30061850 1076732 302258..302656 1 NC_004741.1 YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function; toxin YafO 302656 yafO 1076732 yafO Shigella flexneri 2a str. 2457T toxin YafO NP_836021.1 302258 D 198215 CDS NP_836022.1 30061851 1076733 302666..303118 1 NC_004741.1 residues 1 to 150 of 150 are 91.33 pct identical to residues 1 to 150 of 150 from Escherichia coli K-12 : B0234; hypothetical protein 303118 yafP 1076733 yafP Shigella flexneri 2a str. 2457T hypothetical protein NP_836022.1 302666 D 198215 CDS NP_836023.1 30061852 1076734 303364..304407 1 NC_004741.1 mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 304407 1076734 S0304 Shigella flexneri 2a str. 2457T hypothetical protein NP_836023.1 303364 D 198215 CDS NP_836024.1 30061853 1076735 304523..304978 1 NC_004741.1 catalyzes the release of newly synthesized polypeptide chains at the stop codons UAA and UGA; peptide chain release factor 2 304978 prfH 1076735 prfH Shigella flexneri 2a str. 2457T peptide chain release factor 2 NP_836024.1 304523 D 198215 CDS NP_836025.1 30061854 1076736 complement(305140..306597) 1 NC_004741.1 residues 1 to 485 of 485 are 96.08 pct identical to residues 1 to 485 of 485 from Escherichia coli K-12 : B0237; aminoacyl-histidine dipeptidase 306597 pepD 1076736 pepD Shigella flexneri 2a str. 2457T aminoacyl-histidine dipeptidase NP_836025.1 305140 R 198215 CDS NP_836026.1 30061855 1076737 306859..307317 1 NC_004741.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 307317 gpt 1076737 gpt Shigella flexneri 2a str. 2457T xanthine-guanine phosphoribosyltransferase NP_836026.1 306859 D 198215 CDS NP_836027.1 30061856 1076738 307409..308653 1 NC_004741.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 308653 frsA 1076738 frsA Shigella flexneri 2a str. 2457T fermentation/respiration switch protein NP_836027.1 307409 D 198215 CDS NP_836028.1 30061857 1076739 308711..309112 1 NC_004741.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 309112 crl 1076739 crl Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator Crl NP_836028.1 308711 D 198215 CDS NP_836029.1 30061858 1076740 complement(309151..310206) 1 NC_004741.1 residues 1 to 351 of 351 are 99.71 pct identical to residues 1 to 351 of 351 from Escherichia coli K-12 : B0241; outer membrane phosphoporin protein E 310206 phoE 1076740 phoE Shigella flexneri 2a str. 2457T outer membrane phosphoporin protein E NP_836029.1 309151 R 198215 CDS NP_836030.1 30061859 1076741 310382..310657 1 NC_004741.1 residues 1 to 91 of 91 are 97.80 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 310657 1076741 S0311 Shigella flexneri 2a str. 2457T IS1 orfA NP_836030.1 310382 D 198215 CDS NP_836031.1 30061860 1076742 310576..311079 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 311079 1076742 S0312 Shigella flexneri 2a str. 2457T IS1 orfB NP_836031.1 310576 D 198215 CDS NP_836032.1 30061861 1076743 311270..312373 1 NC_004741.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 312373 proB 1076743 proB Shigella flexneri 2a str. 2457T gamma-glutamyl kinase NP_836032.1 311270 D 198215 CDS NP_836033.1 30061862 1076744 312385..313638 1 NC_004741.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 313638 proA 1076744 proA Shigella flexneri 2a str. 2457T gamma-glutamyl phosphate reductase NP_836033.1 312385 D 198215 CDS NP_836034.1 30061863 1076746 complement(313843..315006) 1 NC_004741.1 residues 1 to 387 of 387 are 98.19 pct identical to residues 1 to 387 of 387 from GenPept : >gb|AAB72135.1| (U82619) integrase [Shigella flexneri bacteriophage V]; phage integrase 315006 1076746 S0316 Shigella flexneri 2a str. 2457T phage integrase NP_836034.1 313843 R 198215 CDS NP_836035.1 30061864 1076747 315192..315494 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 315494 1076747 S0317 Shigella flexneri 2a str. 2457T IS600 orfA NP_836035.1 315192 D 198215 CDS NP_836036.1 30061865 1076748 315635..316348 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 316348 1076748 S0318 Shigella flexneri 2a str. 2457T IS600 orfB NP_836036.1 315635 D 198215 CDS NP_836037.1 30061866 1076749 316401..317051 1 NC_004741.1 residues 1 to 216 of 216 are 90.74 pct identical to residues 1 to 216 of 216 from GenPept : >gb|AAB72130.2| (U82619) unknown [Shigella flexneri bacteriophage V]; hypothetical protein 317051 1076749 S0319 Shigella flexneri 2a str. 2457T hypothetical protein NP_836037.1 316401 D 198215 CDS NP_836038.1 30061867 1080981 316960..317421 1 NC_004741.1 residues 1 to 138 of 153 are 95.65 pct identical to residues 1 to 138 of 167 from Genpept : >gb|AAF09028.1| (AF139596) unknown [Shigella flexneri]; phage tail fibre protein 317421 1080981 S4801 Shigella flexneri 2a str. 2457T phage tail fibre protein NP_836038.1 316960 D 198215 CDS NP_836039.1 30061868 1076750 complement(318229..319278) 1 NC_004741.1 residues 17 to 137 of 349 are 28.12 pct identical to residues 7 to 129 of 337 from Genpept : >gb|AAK80982.1|AE007801_6 (AE007801) O-actetyl transferase related protein [Clostridium acetobutylicum]; hypothetical protein 319278 1076750 S4802 Shigella flexneri 2a str. 2457T hypothetical protein NP_836039.1 318229 R 198215 CDS NP_836040.1 30061869 1076751 319729..320919 1 NC_004741.1 residues 1 to 406 of 406 are 62.62 pct identical to residues 4 to 407 of 407 from NRprotein_Feb03 : >ref|NP_085189.1| IS10 orf [Shigella flexneri] gb|AAK18345.1|AF348706_34 IS10 orf [Shigella flexneri] gb|AAL72480.1| hypothetical protein [Shigella flexneri 2a]; hypothetical protein 320919 1076751 S4808 Shigella flexneri 2a str. 2457T hypothetical protein NP_836040.1 319729 D 198215 CDS NP_836041.1 30061870 1076752 complement(321309..322769) 1 NC_004741.1 residues 1 to 486 of 486 are 81.68 pct identical to residues 1 to 486 of 486 from Genpept : >gb|AAC39273.1| (AF021347) glucosyl tranferase II [bacteriophage SfII]; glucosyl tranferase II 322769 gtrII 1076752 gtrII Shigella flexneri 2a str. 2457T glucosyl tranferase II NP_836041.1 321309 R 198215 CDS NP_836042.1 30061871 1076753 complement(322766..323695) 1 NC_004741.1 residues 1 to 309 of 309 are 94.82 pct identical to residues 1 to 309 of 309 from GenPept : >gb|AAC39272.1| (AF021347) bactoprenol glucosyl transferase [bacteriophage SfII]; bactoprenol glucosyl transferase 323695 gtrBI 1076753 gtrBI Shigella flexneri 2a str. 2457T bactoprenol glucosyl transferase NP_836042.1 322766 R 198215 CDS NP_836043.1 30061872 1076754 complement(323692..324054) 1 NC_004741.1 residues 1 to 120 of 120 are 89.99 pct identical to residues 1 to 120 of 120 from GenPept : >gb|AAB72134.1| (U82619) flippase [Shigella flexneri bacteriophage V]; flippase 324054 gtrAI 1076754 gtrAI Shigella flexneri 2a str. 2457T flippase NP_836043.1 323692 R 198215 CDS NP_836044.1 30061873 1076755 complement(324316..324609) 1 NC_004741.1 residues 1 to 97 of 97 are 100.00 pct identical to residues 290 to 386 of 386 from GenPept : >gb|AAD10295.1| (U82084) integrase [bacteriophage SfX]; integrase fragment 324609 1076755 S0322 Shigella flexneri 2a str. 2457T integrase fragment NP_836044.1 324316 R 198215 CDS NP_836045.1 30061874 1076757 complement(324718..325431) 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 325431 1076757 S0323 Shigella flexneri 2a str. 2457T IS600 orfB NP_836045.1 324718 R 198215 CDS NP_836046.1 30061875 1076758 complement(325572..325874) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 325874 1076758 S0324 Shigella flexneri 2a str. 2457T IS600 orfA NP_836046.1 325572 R 198215 CDS NP_836047.1 30061876 1076759 326060..327223 1 NC_004741.1 residues 1 to 387 of 387 are 98.96 pct identical to residues 1 to 387 of 387 from GenPept : >gb|AAB72135.1| (U82619) integrase [Shigella flexneri bacteriophage V]; phage integrase 327223 1076759 S0325 Shigella flexneri 2a str. 2457T phage integrase NP_836047.1 326060 D 198215 CDS NP_836048.1 30061877 1076760 327572..328744 1 NC_004741.1 residues 39 to 379 of 390 are 28.05 pct identical to residues 15 to 359 of 397 from Genpept : >dbj|BAB50097.1| (AP003001) contains weak similarity to acetyltransferase [Mesorhizobium loti]; hypothetical protein 328744 1076760 S4804 Shigella flexneri 2a str. 2457T hypothetical protein NP_836048.1 327572 D 198215 CDS NP_836049.1 30061878 1076761 complement(329548..329988) 1 NC_004741.1 residues 1 to 146 of 146 are 99.31 pct identical to residues 127 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 329988 1076761 S0326 Shigella flexneri 2a str. 2457T IS600 orfB NP_836049.1 329548 R 198215 CDS NP_836050.1 30061879 1076762 complement(330729..331349) 1 NC_004741.1 residues 1 to 206 of 206 are 100.00 pct identical to residues 1 to 206 of 206 from GenPept : >gb|AAD44736.1|AF141323_7 (AF141323) TnpC [Shigella flexneri]; IS629 orfB 331349 1076762 S0327 Shigella flexneri 2a str. 2457T IS629 orfB NP_836050.1 330729 R 198215 CDS NP_836051.1 30061880 1077809 complement(331711..331929) 1 NC_004741.1 residues 1 to 71 of 72 are 84.50 pct identical to residues 1 to 71 of 108 from GenPept : >gb|AAL72456.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629, orfA 331929 1077809 S0328 Shigella flexneri 2a str. 2457T IS629, orfA NP_836051.1 331711 R 198215 CDS NP_836052.1 30061881 1076603 332080..333195 1 NC_004741.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 333195 adrA 1076603 adrA Shigella flexneri 2a str. 2457T diguanylate cyclase AdrA NP_836052.1 332080 D 198215 CDS NP_836053.1 30061882 1076763 complement(333212..334021) 1 NC_004741.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 334021 proC 1076763 proC Shigella flexneri 2a str. 2457T pyrroline-5-carboxylate reductase NP_836053.1 333212 R 198215 CDS NP_836054.2 161486538 1076764 334141..334599 1 NC_004741.1 residues 1 to 192 of 192 are 93.22 pct identical to residues 1 to 192 of 192 from Escherichia coli K-12 : B0387; hypothetical protein 334599 yaiI 1076764 yaiI Shigella flexneri 2a str. 2457T hypothetical protein NP_836054.2 334141 D 198215 CDS NP_836055.1 30061884 1076765 334782..335306 1 NC_004741.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 335306 aroL 1076765 aroL Shigella flexneri 2a str. 2457T shikimate kinase NP_836055.1 334782 D 198215 CDS NP_836056.1 30061885 1076766 335356..335547 1 NC_004741.1 residues 1 to 63 of 63 are 100.00 pct identical to residues 1 to 63 of 63 from Escherichia coli K-12 : B0389; hypothetical protein 335547 yaiA 1076766 yaiA Shigella flexneri 2a str. 2457T hypothetical protein NP_836056.1 335356 D 198215 CDS NP_836057.1 30061886 1076767 335805..336482 1 NC_004741.1 residues 1 to 225 of 225 are 100.00 pct identical to residues 1 to 225 of 225 from Escherichia coli K-12 : B0390; regulated by aroR; hypothetical protein 336482 aroM 1076767 aroM Shigella flexneri 2a str. 2457T hypothetical protein NP_836057.1 335805 D 198215 CDS NP_836058.1 30061887 1076768 336554..336838 1 NC_004741.1 residues 1 to 94 of 94 are 100.00 pct identical to residues 1 to 94 of 94 from Escherichia coli K-12 : B0391; hypothetical protein 336838 yaiE 1076768 yaiE Shigella flexneri 2a str. 2457T hypothetical protein NP_836058.1 336554 D 198215 CDS NP_836059.1 30061888 1076769 337047..337328 1 NC_004741.1 residues 1 to 93 of 93 are 97.84 pct identical to residues 1 to 93 of 93 from Escherichia coli K-12 : B0392; hypothetical protein 337328 1076769 S0336 Shigella flexneri 2a str. 2457T hypothetical protein NP_836059.1 337047 D 198215 CDS NP_836060.1 30061889 1076770 337325..337780 1 NC_004741.1 ORF2; residues 1 to 144 of 151 are 99.30 pct identical to residues 1 to 144 of 149 from GenPept : >gb|AAG54739.1|AE005218_4 (AE005218) Z0491 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 337780 1076770 S0337 Shigella flexneri 2a str. 2457T hypothetical protein NP_836060.1 337325 D 198215 CDS NP_836061.1 30061890 1076772 complement(337858..338769) 1 NC_004741.1 Required for efficient pilin antigenic variation; recombination associated protein 338769 rdgC 1076772 rdgC Shigella flexneri 2a str. 2457T recombination associated protein NP_836061.1 337858 R 198215 CDS NP_836062.2 161486537 1076773 338894..339787 1 NC_004741.1 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 339787 yajF 1076773 yajF Shigella flexneri 2a str. 2457T fructokinase NP_836062.2 338894 D 198215 CDS NP_836063.1 30061892 1076774 complement(339945..341126) 1 NC_004741.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 341126 araJ 1076774 araJ Shigella flexneri 2a str. 2457T MFS transport protein AraJ NP_836063.1 339945 R 198215 CDS NP_836064.1 30061893 1076775 complement(341252..344395) 1 NC_004741.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease subunit SbcC 344395 sbcC 1076775 sbcC Shigella flexneri 2a str. 2457T exonuclease subunit SbcC NP_836064.1 341252 R 198215 CDS NP_836065.1 30061894 1076776 complement(344392..345594) 1 NC_004741.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease subunit SbcD 345594 sbcD 1076776 sbcD Shigella flexneri 2a str. 2457T exonuclease subunit SbcD NP_836065.1 344392 R 198215 CDS NP_836066.1 30061895 1076777 345784..346473 1 NC_004741.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 346473 phoB 1076777 phoB Shigella flexneri 2a str. 2457T transcriptional regulator PhoB NP_836066.1 345784 D 198215 CDS NP_836067.1 30061896 1076779 346531..347826 1 NC_004741.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 347826 phoR 1076779 phoR Shigella flexneri 2a str. 2457T phosphate regulon sensor protein NP_836067.1 346531 D 198215 CDS NP_836068.1 30061897 1076780 348233..349552 1 NC_004741.1 residues 1 to 439 of 439 are 93.39 pct identical to residues 1 to 439 of 439 from Escherichia coli K-12 : B0401; branched-chain amino acid aminotransferase 349552 brnQ 1076780 brnQ Shigella flexneri 2a str. 2457T branched-chain amino acid aminotransferase NP_836068.1 348233 D 198215 CDS NP_836069.1 30061898 1076781 349628..351001 1 NC_004741.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; proline-specific permease 351001 proY 1076781 proY Shigella flexneri 2a str. 2457T proline-specific permease NP_836069.1 349628 D 198215 CDS NP_836070.1 30061899 1076782 351157..352974 1 NC_004741.1 residues 1 to 605 of 605 are 98.84 pct identical to residues 1 to 605 of 605 from Escherichia coli K-12 : B0403; maltodextrin glucosidase 352974 malZ 1076782 malZ Shigella flexneri 2a str. 2457T maltodextrin glucosidase NP_836070.1 351157 D 198215 CDS NP_836071.1 30061900 1076784 353645..354715 1 NC_004741.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 354715 queA 1076784 queA Shigella flexneri 2a str. 2457T S-adenosylmethionine:tRNA ribosyltransferase-isomerase NP_836071.1 353645 D 198215 CDS NP_836072.1 30061901 1076785 354770..355897 1 NC_004741.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 355897 tgt 1076785 tgt Shigella flexneri 2a str. 2457T queuine tRNA-ribosyltransferase NP_836072.1 354770 D 198215 CDS NP_836073.1 30061902 1076786 355920..356252 1 NC_004741.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 356252 yajC 1076786 yajC Shigella flexneri 2a str. 2457T preprotein translocase subunit YajC NP_836073.1 355920 D 198215 CDS NP_836074.1 30061903 1076787 356280..358127 1 NC_004741.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 358127 secD 1076787 secD Shigella flexneri 2a str. 2457T preprotein translocase subunit SecD NP_836074.1 356280 D 198215 CDS NP_836075.1 30061904 1076788 358138..359109 1 NC_004741.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 359109 secF 1076788 secF Shigella flexneri 2a str. 2457T preprotein translocase subunit SecF NP_836075.1 358138 D 198215 CDS NP_836076.1 30061905 1076789 359238..359585 1 NC_004741.1 residues 1 to 115 of 115 are 100.00 pct identical to residues 1 to 115 of 115 from Escherichia coli K-12 : B0410; hypothetical protein 359585 yajD 1076789 yajD Shigella flexneri 2a str. 2457T hypothetical protein NP_836076.1 359238 D 198215 CDS NP_836077.1 30061906 1076790 complement(359762..360646) 1 NC_004741.1 residues 1 to 294 of 294 are 95.57 pct identical to residues 1 to 294 of 294 from Escherichia coli K-12 : B0411; receptor of phage t6 and colicin K; outer membrane protein Tsx 360646 tsx 1076790 tsx Shigella flexneri 2a str. 2457T outer membrane protein Tsx NP_836077.1 359762 R 198215 CDS NP_836078.2 161486536 1076791 complement(360944..361483) 1 NC_004741.1 residues 1 to 199 of 199 are 93.96 pct identical to residues 1 to 199 of 199 from Escherichia coli K-12 : B0412; hypothetical protein 361483 yajI 1076791 yajI Shigella flexneri 2a str. 2457T hypothetical protein NP_836078.2 360944 R 198215 CDS NP_836079.1 30061908 1076792 361634..362083 1 NC_004741.1 residues 1 to 149 of 149 are 99.32 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B0413; transcriptional regulator NrdR 362083 nrdR 1076792 nrdR Shigella flexneri 2a str. 2457T transcriptional regulator NrdR NP_836079.1 361634 D 198215 CDS NP_836080.1 30061909 1076793 362087..363190 1 NC_004741.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 363190 ribD 1076793 ribD Shigella flexneri 2a str. 2457T bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase NP_836080.1 362087 D 198215 CDS NP_836081.1 30061910 1076794 363279..363749 1 NC_004741.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 363749 ribH 1076794 ribH Shigella flexneri 2a str. 2457T 6,7-dimethyl-8-ribityllumazine synthase NP_836081.1 363279 D 198215 CDS NP_836082.1 30061911 1076795 363769..364188 1 NC_004741.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 364188 nusB 1076795 nusB Shigella flexneri 2a str. 2457T transcription antitermination protein NusB NP_836082.1 363769 D 198215 CDS NP_836083.1 30061912 1076796 364266..365243 1 NC_004741.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 365243 thiL 1076796 thiL Shigella flexneri 2a str. 2457T thiamine monophosphate kinase NP_836083.1 364266 D 198215 CDS NP_836084.1 30061913 1080979 365221..365739 1 NC_004741.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 365739 pgpA 1080979 pgpA Shigella flexneri 2a str. 2457T phosphatidylglycerophosphatase A NP_836084.1 365221 D 198215 CDS NP_836085.1 30061914 1080980 complement(366822..368684) 1 NC_004741.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 368684 dxs 1080980 dxs Shigella flexneri 2a str. 2457T 1-deoxy-D-xylulose-5-phosphate synthase NP_836085.1 366822 R 198215 CDS NP_836086.1 30061915 1076799 complement(368709..369608) 1 NC_004741.1 residues 1 to 299 of 299 are 95.98 pct identical to residues 1 to 299 of 299 from Escherichia coli K-12 : B0421; geranyltranstransferase 369608 ispA 1076799 ispA Shigella flexneri 2a str. 2457T geranyltranstransferase NP_836086.1 368709 R 198215 CDS NP_836087.1 30061916 1076800 complement(369608..369850) 1 NC_004741.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 369850 xseB 1076800 xseB Shigella flexneri 2a str. 2457T exodeoxyribonuclease VII small subunit NP_836087.1 369608 R 198215 CDS NP_836088.1 30061917 1076801 370056..371504 1 NC_004741.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 371504 yajK 1076801 yajK Shigella flexneri 2a str. 2457T thiamine biosynthesis protein ThiI NP_836088.1 370056 D 198215 CDS NP_836089.1 30061918 1076802 complement(371558..372154) 1 NC_004741.1 residues 1 to 198 of 198 are 97.97 pct identical to residues 1 to 198 of 198 from Escherichia coli K-12 : B0424; hypothetical protein 372154 thiJ 1076802 thiJ Shigella flexneri 2a str. 2457T hypothetical protein NP_836089.1 371558 R 198215 CDS NP_836090.1 30061919 1076803 complement(372111..373022) 1 NC_004741.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 373022 apbA 1076803 apbA Shigella flexneri 2a str. 2457T 2-dehydropantoate 2-reductase NP_836090.1 372111 R 198215 CDS NP_836091.1 30061920 1076804 373190..373681 1 NC_004741.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 373681 yajQ 1076804 yajQ Shigella flexneri 2a str. 2457T nucleotide-binding protein NP_836091.1 373190 D 198215 CDS NP_836092.1 30061921 1076805 complement(373741..375471) 1 NC_004741.1 residues 1 to 575 of 576 are 48.69 pct identical to residues 1 to 575 of 576 from NRprotein_Feb03 : >ref|NP_460955.1| periplasmic protein [Salmonella typhimurium LT2] gb|AAL20914.1| periplasmic protein [Salmonella typhimurium LT2]; hypothetical protein 375471 1076805 S4809 Shigella flexneri 2a str. 2457T hypothetical protein NP_836092.1 373741 R 198215 CDS NP_836093.1 30061922 1076806 complement(375524..377677) 1 NC_004741.1 residues 1 to 713 of 717 are 51.59 pct identical to residues 1 to 717 of 720 from NRprotein_Feb03 : >ref|NP_405544.1| exported protein [Yersinia pestis] ref|NP_669630.1| hypothetical [Yersinia pestis KIM] pir||AF0242 probable exported protein YPO1989 [imported] - Yersinia pestis (strain CO92) emb|CAC90802.1; hypothetical protein 377677 1076806 S4810 Shigella flexneri 2a str. 2457T hypothetical protein NP_836093.1 375524 R 198215 CDS NP_836094.1 30061923 1076807 377828..378103 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 378103 1076807 S0372 Shigella flexneri 2a str. 2457T IS1 orfA NP_836094.1 377828 D 198215 CDS NP_836095.1 30061924 1076808 378231..378524 1 NC_004741.1 residues 7 to 103 of 103 are 100.00 pct identical to residues 71 to 167 of 167 from NRprotein_Feb03 : >ref|NP_085209.1| IS1 transposase [Shigella flexneri] ref|NP_706317.1| IS1 transposase [Shigella flexneri 2a str. 301] ref|NP_707672.1| IS1 transposase [Shigella flexneri 2a str. 301] ref|NP_707862.1| IS1 transposase [Shigella flexneri 2a str. 301] ref|NP_708570.1| IS1 transposase [Shigella flexneri; IS1 orfB 378524 1076808 S4811 Shigella flexneri 2a str. 2457T IS1 orfB NP_836095.1 378231 D 198215 CDS NP_836096.1 30061925 1076809 complement(378572..378811) 1 NC_004741.1 residues 1 to 79 of 79 are 100.00 pct identical to residues 54 to 132 of 132 from NRprotein_Feb03 : >ref|NP_706318.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN42025.1|AE015069_8 orf, conserved hypothetical protein [Shigella flexneri 2a str. 301]; hypothetical protein 378811 1076809 S4812 Shigella flexneri 2a str. 2457T hypothetical protein NP_836096.1 378572 R 198215 CDS NP_836097.1 30061926 1076810 complement(379105..379416) 1 NC_004741.1 ORF2; residues 15 to 95 of 103 are 35.80 pct identical to residues 10 to 90 of 95 from GenPept : >dbj|BAA84915.1| (AB024946) orf80 [Escherichia coli]; hypothetical protein 379416 1076810 S0373 Shigella flexneri 2a str. 2457T hypothetical protein NP_836097.1 379105 R 198215 CDS NP_836098.1 30061927 1076811 complement(379600..380487) 1 NC_004741.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 380487 cyoE 1076811 cyoE Shigella flexneri 2a str. 2457T protoheme IX farnesyltransferase NP_836098.1 379600 R 198215 CDS NP_836099.1 30061928 1076812 complement(380502..380831) 1 NC_004741.1 residues 1 to 109 of 109 are 100.00 pct identical to residues 1 to 109 of 109 from Escherichia coli K-12 : B0429; cytochrome o ubiquinol oxidase subunit IV 380831 cyoD 1076812 cyoD Shigella flexneri 2a str. 2457T cytochrome o ubiquinol oxidase subunit IV NP_836099.1 380502 R 198215 CDS NP_836100.1 30061929 1076815 complement(380831..381445) 1 NC_004741.1 residues 25 to 204 of 204 are 100.00 pct identical to residues 25 to 204 of 204 from Escherichia coli K-12 : B0430; cytochrome o ubiquinol oxidase subunit III 381445 cyoC 1076815 cyoC Shigella flexneri 2a str. 2457T cytochrome o ubiquinol oxidase subunit III NP_836100.1 380831 R 198215 CDS NP_836101.1 30061930 1076818 complement(383978..385027) 1 NC_004741.1 residues 1 to 349 of 349 are 99.71 pct identical to residues 2 to 350 of 350 from GenPept : >gb|AAK18526.1|AF348706_215 (AF348706) IS orf [Shigella flexneri]; ISSfl3 orfD 385027 1076818 S0379 Shigella flexneri 2a str. 2457T ISSfl3 orfD NP_836101.1 383978 R 198215 CDS NP_836102.2 146133915 1076819 complement(385243..385431) 1 NC_004741.1 residues 1 to 59 of 62 are 88.13 pct identical to residues 273 to 331 of 533 from GenPept : >gb|AAL72376.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; ISSfl3 orfC 385431 1076819 S0380 Shigella flexneri 2a str. 2457T ISSfl3 orfC NP_836102.2 385243 R 198215 CDS NP_836103.1 30061932 1076820 complement(385428..385562) 1 NC_004741.1 residues 1 to 36 of 44 are 100.00 pct identical to residues 1 to 36 of 533 from GenPept : >gb|AAL72472.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; ISSfl3 orfC 385562 1076820 S0381 Shigella flexneri 2a str. 2457T ISSfl3 orfC NP_836103.1 385428 R 198215 CDS NP_836104.1 30061933 1076821 complement(385582..385929) 1 NC_004741.1 residues 1 to 115 of 115 are 100.00 pct identical to residues 1 to 115 of 115 from GenPept : >gb|AAL72465.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfB 385929 1076821 S0382 Shigella flexneri 2a str. 2457T ISSfl3 orfB NP_836104.1 385582 R 198215 CDS NP_836105.1 30061934 1076822 complement(385926..386423) 1 NC_004741.1 residues 1 to 165 of 165 are 98.78 pct identical to residues 60 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 386423 1076822 S0383 Shigella flexneri 2a str. 2457T ISSfl3 orfA NP_836105.1 385926 R 198215 CDS NP_836106.1 30061935 1076823 complement(386970..388445) 1 NC_004741.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 388445 ampG 1076823 ampG Shigella flexneri 2a str. 2457T muropeptide transporter NP_836106.1 386970 R 198215 CDS NP_836107.2 161486535 1076824 complement(388489..389067) 1 NC_004741.1 residues 1 to 226 of 226 are 93.80 pct identical to residues 1 to 226 of 226 from Escherichia coli K-12 : B0434; hypothetical protein 389067 yajG 1076824 yajG Shigella flexneri 2a str. 2457T hypothetical protein NP_836107.2 388489 R 198215 CDS NP_836108.2 161486534 1076825 389372..389689 1 NC_004741.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 389689 bolA 1076825 bolA Shigella flexneri 2a str. 2457T transcriptional regulator BolA NP_836108.2 389372 D 198215 CDS NP_836109.1 30061938 1076826 390033..391331 1 NC_004741.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 391331 tig 1076826 tig Shigella flexneri 2a str. 2457T trigger factor NP_836109.1 390033 D 198215 CDS NP_836110.1 30061939 1076827 391578..392201 1 NC_004741.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 392201 clpP 1076827 clpP Shigella flexneri 2a str. 2457T ATP-dependent Clp protease proteolytic subunit NP_836110.1 391578 D 198215 CDS NP_836111.1 30061940 1076828 392327..393601 1 NC_004741.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 393601 clpX 1076828 clpX Shigella flexneri 2a str. 2457T ATP-dependent protease ATP-binding subunit ClpX NP_836111.1 392327 D 198215 CDS NP_836112.1 30061941 1076829 393789..396143 1 NC_004741.1 residues 1 to 784 of 784 are 97.83 pct identical to residues 1 to 784 of 784 from Escherichia coli K-12 : B0439; DNA-binding ATP-dependent protease La 396143 lon 1076829 lon Shigella flexneri 2a str. 2457T DNA-binding ATP-dependent protease La NP_836112.1 393789 D 198215 CDS NP_836113.1 30061942 1076830 396352..396624 1 NC_004741.1 histone-like DNA-binding protein; transcriptional regulator HU subunit beta 396624 hupB 1076830 hupB Shigella flexneri 2a str. 2457T transcriptional regulator HU subunit beta NP_836113.1 396352 D 198215 CDS NP_836114.1 30061943 1076831 396816..398687 1 NC_004741.1 residues 1 to 623 of 623 are 96.95 pct identical to residues 1 to 623 of 623 from Escherichia coli K-12 : B0441; peptidyl-prolyl cis-trans isomerase (rotamase D) 398687 ybaU 1076831 ybaU Shigella flexneri 2a str. 2457T peptidyl-prolyl cis-trans isomerase (rotamase D) NP_836114.1 396816 D 198215 CDS NP_836115.1 30061944 1076832 398838..399209 1 NC_004741.1 residues 1 to 123 of 123 are 85.36 pct identical to residues 1 to 123 of 123 from Escherichia coli K-12 : B0442; hypothetical protein 399209 ybaV 1076832 ybaV Shigella flexneri 2a str. 2457T hypothetical protein NP_836115.1 398838 D 198215 CDS NP_836116.1 30061945 1076833 399303..399701 1 NC_004741.1 residues 1 to 132 of 132 are 89.39 pct identical to residues 1 to 132 of 132 from Escherichia coli K-12 : B0443; hypothetical protein 399701 ybaW 1076833 ybaW Shigella flexneri 2a str. 2457T hypothetical protein NP_836116.1 399303 D 198215 CDS NP_836117.1 30061946 1076834 complement(399753..400448) 1 NC_004741.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 400448 ybaX 1076834 ybaX Shigella flexneri 2a str. 2457T queuosine biosynthesis protein QueC NP_836117.1 399753 R 198215 CDS NP_836118.1 30061947 1076837 402293..403123 1 NC_004741.1 residues 1 to 276 of 276 are 98.18 pct identical to residues 1 to 276 of 276 from Escherichia coli K-12 : B0446; hypothetical protein 403123 cof 1076837 cof Shigella flexneri 2a str. 2457T hypothetical protein NP_836118.1 402293 D 198215 CDS NP_836119.1 30061948 1076838 403190..403735 1 NC_004741.1 residues 1 to 181 of 181 are 98.34 pct identical to residues 1 to 181 of 181 from Escherichia coli K-12 : B0447; LRP-like transcriptional regulator 403735 ybaO 1076838 ybaO Shigella flexneri 2a str. 2457T LRP-like transcriptional regulator NP_836119.1 403190 D 198215 CDS NP_836120.1 30061949 1076839 403765..405537 1 NC_004741.1 residues 1 to 590 of 590 are 96.61 pct identical to residues 1 to 590 of 590 from Escherichia coli K-12 : B0448; multidrug transporter membrane\ATP-binding components 405537 mdlA 1076839 mdlA Shigella flexneri 2a str. 2457T multidrug transporter membrane\ATP-binding components NP_836120.1 403765 D 198215 CDS NP_836121.1 30061950 1076840 405530..407311 1 NC_004741.1 residues 1 to 593 of 593 are 91.73 pct identical to residues 1 to 593 of 593 from Escherichia coli K-12 : B0449; multidrug transporter membrane\ATP-binding components 407311 mdlB 1076840 mdlB Shigella flexneri 2a str. 2457T multidrug transporter membrane\ATP-binding components NP_836121.1 405530 D 198215 CDS NP_836122.1 30061951 1076841 407492..407830 1 NC_004741.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 407830 glnK 1076841 glnK Shigella flexneri 2a str. 2457T nitrogen regulatory protein P-II 2 NP_836122.1 407492 D 198215 CDS NP_836123.1 30061952 1076842 407860..409146 1 NC_004741.1 residues 1 to 428 of 428 are 82.94 pct identical to residues 1 to 428 of 428 from Escherichia coli K-12 : B0451; ammonium transporter 409146 amtB 1076842 amtB Shigella flexneri 2a str. 2457T ammonium transporter NP_836123.1 407860 D 198215 CDS NP_836124.1 30061953 1080558 complement(409195..410055) 1 NC_004741.1 residues 1 to 286 of 286 are 96.15 pct identical to residues 1 to 286 of 286 from Escherichia coli K-12 : B0452; acyl-CoA thioesterase II 410055 tesB 1080558 tesB Shigella flexneri 2a str. 2457T acyl-CoA thioesterase II NP_836124.1 409195 R 198215 CDS NP_836125.1 30061954 1076843 410273..410845 1 NC_004741.1 residues 1 to 190 of 190 are 75.26 pct identical to residues 1 to 190 of 190 from Escherichia coli K-12 : B0453; involved in glycoprotein/polysaccharide metabolism; hypothetical protein 410845 ybaY 1076843 ybaY Shigella flexneri 2a str. 2457T hypothetical protein NP_836125.1 410273 D 198215 CDS NP_836126.1 30061955 1076844 410956..412284 1 NC_004741.1 residues 1 to 442 of 442 are 99.32 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 412284 1076844 S0405 Shigella flexneri 2a str. 2457T IS4 orf NP_836126.1 410956 D 198215 CDS NP_836127.1 30061956 1076845 complement(412314..412625) 1 NC_004741.1 residues 1 to 103 of 103 are 100.00 pct identical to residues 27 to 129 of 129 from Escherichia coli K-12 : B0454; hypothetical protein 412625 ybaZ 1076845 ybaZ Shigella flexneri 2a str. 2457T hypothetical protein NP_836127.1 412314 R 198215 CDS NP_836128.1 30061957 1076847 413004..413357 1 NC_004741.1 residues 1 to 117 of 117 are 100.00 pct identical to residues 1 to 117 of 117 from Escherichia coli K-12 : B0456; hypothetical protein 413357 ybaA 1076847 ybaA Shigella flexneri 2a str. 2457T hypothetical protein NP_836128.1 413004 D 198215 CDS NP_836129.1 30061958 1076848 complement(413399..414949) 1 NC_004741.1 residues 1 to 516 of 516 are 94.37 pct identical to residues 3 to 518 of 518 from Escherichia coli K-12 : B0457; hypothetical protein 414949 ylaB 1076848 ylaB Shigella flexneri 2a str. 2457T hypothetical protein NP_836129.1 413399 R 198215 CDS NP_836130.1 30061959 1076849 complement(415113..415583) 1 NC_004741.1 residues 1 to 156 of 156 are 100.00 pct identical to residues 14 to 169 of 169 from Escherichia coli K-12 : B0458; hypothetical protein 415583 ylaC 1076849 ylaC Shigella flexneri 2a str. 2457T hypothetical protein NP_836130.1 415113 R 198215 CDS NP_836131.1 30061960 1076851 complement(416422..416640) 1 NC_004741.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 416640 hha 1076851 hha Shigella flexneri 2a str. 2457T hemolysin expression-modulating protein NP_836131.1 416422 R 198215 CDS NP_836132.1 30061961 1076852 complement(416666..417040) 1 NC_004741.1 residues 1 to 124 of 124 are 99.19 pct identical to residues 1 to 124 of 124 from Escherichia coli K-12 : B0461; hypothetical protein 417040 ybaJ 1076852 ybaJ Shigella flexneri 2a str. 2457T hypothetical protein NP_836132.1 416666 R 198215 CDS NP_836133.1 30061962 1076853 complement(417586..420735) 1 NC_004741.1 residues 1 to 1049 of 1049 are 94.47 pct identical to residues 1 to 1049 of 1049 from Escherichia coli K-12 : B0462; acriflavine resistance protein 420735 acrB 1076853 acrB Shigella flexneri 2a str. 2457T acriflavine resistance protein NP_836133.1 417586 R 198215 CDS NP_836134.1 30061963 1076854 complement(420758..421951) 1 NC_004741.1 residues 1 to 397 of 397 are 90.17 pct identical to residues 1 to 397 of 397 from Escherichia coli K-12 : B0463; acriflavin resistance protein AcrA precursor 421951 acrA 1076854 acrA Shigella flexneri 2a str. 2457T acriflavin resistance protein AcrA precursor NP_836134.1 420758 R 198215 CDS NP_836135.1 30061964 1076855 422093..422740 1 NC_004741.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 422740 acrR 1076855 acrR Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor AcrR NP_836135.1 422093 D 198215 CDS NP_836136.1 30061965 1076856 422868..426230 1 NC_004741.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 426230 aefA 1076856 aefA Shigella flexneri 2a str. 2457T potassium efflux protein KefA NP_836136.1 422868 D 198215 CDS NP_836137.1 30061966 1076857 complement(426442..426603) 1 NC_004741.1 residues 1 to 53 of 53 are 98.11 pct identical to residues 1 to 53 of 53 from Escherichia coli K-12 : B0466; hypothetical protein 426603 ybaM 1076857 ybaM Shigella flexneri 2a str. 2457T hypothetical protein NP_836137.1 426442 R 198215 CDS NP_836138.1 30061967 1076858 complement(426617..427144) 1 NC_004741.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 427144 priC 1076858 priC Shigella flexneri 2a str. 2457T primosomal replication protein N'' NP_836138.1 426617 R 198215 CDS NP_836139.1 30061968 1076859 427214..427591 1 NC_004741.1 residues 1 to 125 of 125 are 86.40 pct identical to residues 1 to 125 of 125 from Escherichia coli K-12 : B0468; hypothetical protein 427591 ybaN 1076859 ybaN Shigella flexneri 2a str. 2457T hypothetical protein NP_836139.1 427214 D 198215 CDS NP_836140.1 30061969 1076860 427744..428295 1 NC_004741.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 428295 apt 1076860 apt Shigella flexneri 2a str. 2457T adenine phosphoribosyltransferase NP_836140.1 427744 D 198215 CDS NP_836141.1 30061970 1076861 428424..430349 1 NC_004741.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 430349 dnaX 1076861 dnaX Shigella flexneri 2a str. 2457T DNA polymerase III subunits gamma and tau NP_836141.1 428424 D 198215 CDS NP_836142.1 30061971 1076862 430402..430731 1 NC_004741.1 residues 1 to 109 of 109 are 70.64 pct identical to residues 1 to 109 of 109 from Escherichia coli K-12 : B0471; hypothetical protein 430731 ybaB 1076862 ybaB Shigella flexneri 2a str. 2457T hypothetical protein NP_836142.1 430402 D 198215 CDS NP_836143.1 30061972 1076863 430731..431336 1 NC_004741.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 431336 recR 1076863 recR Shigella flexneri 2a str. 2457T recombination protein RecR NP_836143.1 430731 D 198215 CDS NP_836144.1 30061973 1076864 431446..433320 1 NC_004741.1 molecular chaperone; heat shock protein 90 433320 htpG 1076864 htpG Shigella flexneri 2a str. 2457T heat shock protein 90 NP_836144.1 431446 D 198215 CDS NP_836145.1 30061974 1080956 433501..434145 1 NC_004741.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 434145 adk 1080956 adk Shigella flexneri 2a str. 2457T adenylate kinase NP_836145.1 433501 D 198215 CDS NP_836146.1 30061975 1080922 434277..435239 1 NC_004741.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 435239 hemH 1080922 hemH Shigella flexneri 2a str. 2457T ferrochelatase NP_836146.1 434277 D 198215 CDS NP_836147.1 30061976 1076865 complement(435377..436195) 1 NC_004741.1 residues 1 to 272 of 272 are 92.64 pct identical to residues 1 to 272 of 319 from Escherichia coli K-12 : B0476; lipase 436195 ybaC 1076865 ybaC Shigella flexneri 2a str. 2457T lipase NP_836147.1 435377 R 198215 CDS NP_836148.1 30061977 1076866 436347..437651 1 NC_004741.1 residues 1 to 434 of 434 are 96.77 pct identical to residues 1 to 434 of 434 from Escherichia coli K-12 : B0477; inosine-guanosine kinase 437651 gsk 1076866 gsk Shigella flexneri 2a str. 2457T inosine-guanosine kinase NP_836148.1 436347 D 198215 CDS NP_836149.1 30061978 1076867 complement(437784..439460) 1 NC_004741.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein 439460 ybaL 1076867 ybaL Shigella flexneri 2a str. 2457T cation:proton antiport protein NP_836149.1 437784 R 198215 CDS NP_836150.1 30061979 1076868 complement(439698..440918) 1 NC_004741.1 residues 1 to 406 of 406 are 77.83 pct identical to residues 1 to 406 of 406 from Escherichia coli K-12 : B0479; fosmidomycin resistance protein 440918 fsr 1076868 fsr Shigella flexneri 2a str. 2457T fosmidomycin resistance protein NP_836150.1 439698 R 198215 CDS NP_836151.1 30061980 1076869 441136..442788 1 NC_004741.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor 442788 ushA 1076869 ushA Shigella flexneri 2a str. 2457T bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor NP_836151.1 441136 D 198215 CDS NP_836152.1 30061981 1076870 complement(442825..443304) 1 NC_004741.1 residues 1 to 159 of 159 are 91.82 pct identical to residues 1 to 159 of 159 from Escherichia coli K-12 : B0481; hypothetical protein 443304 ybaK 1076870 ybaK Shigella flexneri 2a str. 2457T hypothetical protein NP_836152.1 442825 R 198215 CDS NP_836153.1 30061982 1076872 complement(443508..444302) 1 NC_004741.1 residues 1 to 264 of 264 are 100.00 pct identical to residues 1 to 264 of 264 from Escherichia coli K-12 : B0482; ligase 444302 ybaP 1076872 ybaP Shigella flexneri 2a str. 2457T ligase NP_836153.1 443508 R 198215 CDS NP_836154.1 30061983 1076873 444386..444781 1 NC_004741.1 residues 1 to 131 of 131 are 97.70 pct identical to residues 1 to 131 of 131 from Escherichia coli K-12 : B0483; hypothetical protein 444781 ybaQ 1076873 ybaQ Shigella flexneri 2a str. 2457T hypothetical protein NP_836154.1 444386 D 198215 CDS NP_836155.1 30061984 1076874 complement(444996..447500) 1 NC_004741.1 residues 1 to 834 of 834 are 93.64 pct identical to residues 1 to 834 of 834 from Escherichia coli K-12 : B0484; copper exporting ATPase 447500 copA 1076874 copA Shigella flexneri 2a str. 2457T copper exporting ATPase NP_836155.1 444996 R 198215 CDS NP_836156.1 30061985 1076875 447762..448694 1 NC_004741.1 catalyzes the formation of glutamate from glutamine; glutaminase 448694 ybaS 1076875 ybaS Shigella flexneri 2a str. 2457T glutaminase NP_836156.1 447762 D 198215 CDS NP_836157.1 30061986 1076876 448697..449989 1 NC_004741.1 residues 1 to 430 of 430 are 86.51 pct identical to residues 1 to 430 of 430 from Escherichia coli K-12 : B0486; amino acid/amine transport protein 449989 ybaT 1076876 ybaT Shigella flexneri 2a str. 2457T amino acid/amine transport protein NP_836157.1 448697 D 198215 CDS NP_836158.1 30061987 1076877 450114..450521 1 NC_004741.1 activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 450521 ybbI 1076877 ybbI Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator CueR NP_836158.1 450114 D 198215 CDS NP_836159.1 30061988 1076878 complement(450522..450977) 1 NC_004741.1 residues 1 to 151 of 151 are 81.45 pct identical to residues 1 to 151 of 151 from Escherichia coli K-12 : B0488; hypothetical protein 450977 ybbJ 1076878 ybbJ Shigella flexneri 2a str. 2457T hypothetical protein NP_836159.1 450522 R 198215 CDS NP_836160.1 30061989 1076879 complement(450977..451894) 1 NC_004741.1 residues 1 to 305 of 305 are 95.40 pct identical to residues 1 to 305 of 305 from Escherichia coli K-12 : B0489; protease 451894 ybbK 1076879 ybbK Shigella flexneri 2a str. 2457T protease NP_836160.1 450977 R 198215 CDS NP_836161.1 30061990 1076880 452040..452717 1 NC_004741.1 residues 1 to 225 of 225 are 98.66 pct identical to residues 1 to 225 of 225 from Escherichia coli K-12 : B0490; ABC transporter ATP-binding protein 452717 ybbL 1076880 ybbL Shigella flexneri 2a str. 2457T ABC transporter ATP-binding protein NP_836161.1 452040 D 198215 CDS NP_836162.1 30061991 1076881 452677..453483 1 NC_004741.1 residues 1 to 268 of 268 are 89.55 pct identical to residues 1 to 268 of 268 from Escherichia coli K-12 : B0491; metal resistance protein 453483 ybbM 1076881 ybbM Shigella flexneri 2a str. 2457T metal resistance protein NP_836162.1 452677 D 198215 CDS NP_836163.1 30061992 1076882 complement(453546..454436) 1 NC_004741.1 residues 1 to 296 of 296 are 95.60 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 : B0492; thioredoxin-like protein 454436 ybbN 1076882 ybbN Shigella flexneri 2a str. 2457T thioredoxin-like protein NP_836163.1 453546 R 198215 CDS NP_836164.1 30061993 1076883 complement(454461..455270) 1 NC_004741.1 residues 1 to 269 of 269 are 98.51 pct identical to residues 1 to 269 of 269 from Escherichia coli K-12 : B0493; short chain dehydrogenase 455270 ybbO 1076883 ybbO Shigella flexneri 2a str. 2457T short chain dehydrogenase NP_836164.1 454461 R 198215 CDS NP_836165.1 30061994 1076886 455853..456539 1 NC_004741.1 residues 1 to 228 of 228 are 100.00 pct identical to residues 1 to 228 of 228 from Escherichia coli K-12 : B0495; ABC transporter ATP-binding protein 456539 ybbA 1076886 ybbA Shigella flexneri 2a str. 2457T ABC transporter ATP-binding protein NP_836165.1 455853 D 198215 CDS NP_836166.1 30061995 1076888 complement(459664..460758) 1 NC_004741.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 460758 ybbB 1076888 ybbB Shigella flexneri 2a str. 2457T tRNA 2-selenouridine synthase NP_836166.1 459664 R 198215 CDS NP_836167.1 30061996 1076889 complement(460827..461753) 1 NC_004741.1 activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS 461753 ybbS 1076889 ybbS Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator AllS NP_836167.1 460827 R 198215 CDS NP_836168.1 30061997 1076890 461983..462465 1 NC_004741.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 462465 ybbT 1076890 ybbT Shigella flexneri 2a str. 2457T ureidoglycolate hydrolase NP_836168.1 461983 D 198215 CDS NP_836169.1 30061998 1076891 462543..463358 1 NC_004741.1 regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 463358 ybbU 1076891 ybbU Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor AllR NP_836169.1 462543 D 198215 CDS NP_836170.1 30061999 1076892 463448..465229 1 NC_004741.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 465229 gcl 1076892 gcl Shigella flexneri 2a str. 2457T glyoxylate carboligase NP_836170.1 463448 D 198215 CDS NP_836171.1 30062000 1076893 465242..465523 1 NC_004741.1 residues 1 to 93 of 93 are 97.84 pct identical to residues 1 to 93 of 258 from Escherichia coli K-12 : B0508; glyoxylate-induced protein 465523 gip 1076893 gip Shigella flexneri 2a str. 2457T glyoxylate-induced protein NP_836171.1 465242 D 198215 CDS NP_836172.1 30062001 1076894 complement(465534..466037) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 466037 1076894 S0455 Shigella flexneri 2a str. 2457T IS1 orfB NP_836172.1 465534 R 198215 CDS NP_836173.1 30062002 1076895 complement(465956..466231) 1 NC_004741.1 residues 1 to 91 of 91 are 97.80 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 466231 1076895 S0456 Shigella flexneri 2a str. 2457T IS1 orfA NP_836173.1 465956 R 198215 CDS NP_836174.1 30062003 1076896 complement(466260..466931) 1 NC_004741.1 residues 1 to 217 of 223 are 91.70 pct identical to residues 1 to 217 of 261 from Escherichia coli K-12 : B0515; hypothetical protein 466931 ylbA 1076896 ylbA Shigella flexneri 2a str. 2457T hypothetical protein NP_836174.1 466260 R 198215 CDS NP_836175.2 229089135 1076897 complement(466942..468231) 1 NC_004741.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 468231 ylbB 1076897 ylbB Shigella flexneri 2a str. 2457T allantoate amidohydrolase NP_836175.2 466942 R 198215 CDS NP_836176.1 30062005 1076899 468821..469714 1 NC_004741.1 forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate; carbamate kinase 469714 arcC 1076899 arcC Shigella flexneri 2a str. 2457T carbamate kinase NP_836176.1 468821 D 198215 CDS NP_836177.1 30062006 1076900 complement(469852..470919) 1 NC_004741.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 470919 purK 1076900 purK Shigella flexneri 2a str. 2457T phosphoribosylaminoimidazole carboxylase ATPase subunit NP_836177.1 469852 R 198215 CDS NP_836178.1 30062007 1076901 complement(470916..471425) 1 NC_004741.1 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit 471425 purE 1076901 purE Shigella flexneri 2a str. 2457T phosphoribosylaminoimidazole carboxylase catalytic subunit NP_836178.1 470916 R 198215 CDS NP_836179.1 30062008 1076902 complement(471543..472265) 1 NC_004741.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 472265 ybbF 1076902 ybbF Shigella flexneri 2a str. 2457T UDP-2,3-diacylglucosamine hydrolase NP_836179.1 471543 R 198215 CDS NP_836180.1 30062009 1076903 complement(472268..472762) 1 NC_004741.1 residues 1 to 164 of 164 are 99.39 pct identical to residues 1 to 164 of 164 from Escherichia coli K-12 : B0525; peptidyl-prolyl cis-trans isomerase B (rotamase B) 472762 ppiB 1076903 ppiB Shigella flexneri 2a str. 2457T peptidyl-prolyl cis-trans isomerase B (rotamase B) NP_836180.1 472268 R 198215 CDS NP_836181.1 30062010 1076904 472936..474321 1 NC_004741.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 474321 cysS 1076904 cysS Shigella flexneri 2a str. 2457T cysteinyl-tRNA synthetase NP_836181.1 472936 D 198215 CDS NP_836182.1 30062011 1076905 complement(474357..474866) 1 NC_004741.1 residues 1 to 149 of 169 are 85.62 pct identical to residues 1 to 153 of 173 from Escherichia coli K-12 : B0527; hypothetical protein 474866 ybcI 1076905 ybcI Shigella flexneri 2a str. 2457T hypothetical protein NP_836182.1 474357 R 198215 CDS NP_836183.2 161486533 1076906 complement(474974..475186) 1 NC_004741.1 residues 1 to 77 of 77 are 98.70 pct identical to residues 1 to 77 of 77 from Escherichia coli K-12 : B0528; hypothetical protein 475186 ybcJ 1076906 ybcJ Shigella flexneri 2a str. 2457T hypothetical protein NP_836183.2 474974 R 198215 CDS NP_836184.1 30062013 1076907 complement(475188..476054) 1 NC_004741.1 residues 1 to 288 of 288 are 99.30 pct identical to residues 1 to 288 of 288 from Escherichia coli K-12 : B0529; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 476054 folD 1076907 folD Shigella flexneri 2a str. 2457T bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase NP_836184.1 475188 R 198215 CDS NP_836185.1 30062014 1076908 476502..477077 1 NC_004741.1 residues 1 to 191 of 191 are 90.57 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B0530; fimbrial-like protein 477077 sfmA 1076908 sfmA Shigella flexneri 2a str. 2457T fimbrial-like protein NP_836185.1 476502 D 198215 CDS NP_836186.1 30062015 1076909 477297..477989 1 NC_004741.1 residues 13 to 230 of 230 are 90.82 pct identical to residues 13 to 230 of 230 from Escherichia coli K-12 : B0531; chaperone 477989 sfmC 1076909 sfmC Shigella flexneri 2a str. 2457T chaperone NP_836186.1 477297 D 198215 CDS NP_836187.1 30062016 1076910 complement(478532..479035) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 479035 1076910 S0471 Shigella flexneri 2a str. 2457T IS1 orfB NP_836187.1 478532 R 198215 CDS NP_836188.1 30062017 1076911 complement(478954..479229) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 479229 1076911 S0472 Shigella flexneri 2a str. 2457T IS1 orfA NP_836188.1 478954 R 198215 CDS NP_836189.1 30062018 1076915 complement(479858..480619) 1 NC_004741.1 residues 1 to 253 of 253 are 92.09 pct identical to residues 1 to 253 of 253 from Escherichia coli K-12 : B0566; involved in thermoregulation of porin biosynthesis; envelope protein 480619 envY 1076915 envY Shigella flexneri 2a str. 2457T envelope protein NP_836189.1 479858 R 198215 CDS NP_836190.1 30062019 1076916 complement(480802..481692) 1 NC_004741.1 residues 1 to 296 of 296 are 93.24 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 : B0567; hypothetical protein 481692 ybcH 1076916 ybcH Shigella flexneri 2a str. 2457T hypothetical protein NP_836190.1 480802 R 198215 CDS NP_836191.1 30062020 1076919 complement(487035..488477) 1 NC_004741.1 residues 1 to 480 of 480 are 88.95 pct identical to residues 1 to 480 of 480 from Escherichia coli K-12 : B0570; sensor kinase CusS 488477 ybcZ 1076919 ybcZ Shigella flexneri 2a str. 2457T sensor kinase CusS NP_836191.1 487035 R 198215 CDS NP_836192.1 30062021 1076921 complement(488467..489150) 1 NC_004741.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 489150 ylcA 1076921 ylcA Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator CusR NP_836192.1 488467 R 198215 CDS NP_836193.1 30062022 1076922 489307..490689 1 NC_004741.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 490689 ylcB 1076922 ylcB Shigella flexneri 2a str. 2457T copper/silver efflux system outer membrane protein CusC NP_836193.1 489307 D 198215 CDS NP_836194.1 30062023 1076923 490713..491045 1 NC_004741.1 residues 1 to 110 of 110 are 99.09 pct identical to residues 1 to 110 of 110 from Escherichia coli K-12 : B0573; periplasmic copper-binding protein 491045 ylcC 1076923 ylcC Shigella flexneri 2a str. 2457T periplasmic copper-binding protein NP_836194.1 490713 D 198215 CDS NP_836195.1 30062024 1076925 491986..492309 1 NC_004741.1 residues 3 to 104 of 107 are 42.85 pct identical to residues 16 to 120 of 409 from GenPept : >gb|AAF28112.1|AF153317_4 (AF153317) integrase [Shigella dysenteriae]; IntA 492309 1076925 S0484 Shigella flexneri 2a str. 2457T IntA NP_836195.1 491986 D 198215 CDS NP_836196.1 30062025 1078534 complement(492349..492969) 1 NC_004741.1 residues 1 to 206 of 206 are 100.00 pct identical to residues 1 to 206 of 206 from GenPept : >gb|AAD44736.1|AF141323_7 (AF141323) TnpC [Shigella flexneri]; partial; IS629 orfB 492969 1078534 S0485 Shigella flexneri 2a str. 2457T IS629 orfB NP_836196.1 492349 R 198215 CDS NP_836197.1 30062026 1076926 complement(493232..493558) 1 NC_004741.1 residues 1 to 108 of 108 are 89.81 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72456.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA 493558 1076926 S0486 Shigella flexneri 2a str. 2457T IS629 orfA NP_836197.1 493232 R 198215 CDS NP_836198.1 30062027 1076927 complement(494699..495490) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfB protein 495490 1076927 S0487 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfB protein NP_836198.1 494699 R 198215 CDS NP_836199.1 30062028 1076928 complement(495562..495972) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 495972 1076928 S0488 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_836199.1 495562 R 198215 CDS NP_836200.1 30062029 1076929 496745..499888 1 NC_004741.1 residues 1 to 1046 of 1047 are 96.36 pct identical to residues 1 to 1046 of 1047 from Escherichia coli K-12 : B0575; inner membrane component for iron transport 499888 ybdE 1076929 ybdE Shigella flexneri 2a str. 2457T inner membrane component for iron transport NP_836200.1 496745 D 198215 CDS NP_836201.1 30062030 1076930 499989..501365 1 NC_004741.1 residues 1 to 458 of 458 are 89.95 pct identical to residues 1 to 458 of 458 from Escherichia coli K-12 : B0576; phenylalanine transporter 501365 pheP 1076930 pheP Shigella flexneri 2a str. 2457T phenylalanine transporter NP_836201.1 499989 D 198215 CDS NP_836202.1 30062031 1076931 complement(501433..502680) 1 NC_004741.1 residues 1 to 415 of 415 are 97.10 pct identical to residues 1 to 415 of 415 from Escherichia coli K-12 : B0577; transporter 502680 ybdG 1076931 ybdG Shigella flexneri 2a str. 2457T transporter NP_836202.1 501433 R 198215 CDS NP_836203.1 30062032 1077000 complement(502788..503441) 1 NC_004741.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 503441 nfnB 1077000 nfnB Shigella flexneri 2a str. 2457T dihydropteridine reductase NP_836203.1 502788 R 198215 CDS NP_836204.1 30062033 1076932 complement(503535..503903) 1 NC_004741.1 residues 1 to 122 of 122 are 99.18 pct identical to residues 1 to 122 of 122 from Escherichia coli K-12 : B0579; hypothetical protein 503903 ybdF 1076932 ybdF Shigella flexneri 2a str. 2457T hypothetical protein NP_836204.1 503535 R 198215 CDS NP_836205.1 30062034 1076933 complement(503968..504216) 1 NC_004741.1 residues 1 to 82 of 82 are 78.04 pct identical to residues 1 to 82 of 82 from Escherichia coli K-12 : B0580; hypothetical protein 504216 ybdJ 1076933 ybdJ Shigella flexneri 2a str. 2457T hypothetical protein NP_836205.1 503968 R 198215 CDS NP_836206.1 30062035 1076934 complement(504282..505400) 1 NC_004741.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 505400 ybdK 1076934 ybdK Shigella flexneri 2a str. 2457T carboxylate-amine ligase NP_836206.1 504282 R 198215 CDS NP_836207.1 30062036 1077940 505832..506353 1 NC_004741.1 residues 1 to 173 of 173 are 100.00 pct identical to residues 1 to 173 of 173 from GenPept : >gb|AAB18534.1| (U00039) orfA in IS150 [Escherichia coli]; IS103 orf 506353 IS103 1077940 IS103 Shigella flexneri 2a str. 2457T IS103 orf NP_836207.1 505832 D 198215 CDS NP_836208.1 30062037 1076935 506350..506781 1 NC_004741.1 residues 1 to 117 of 143 are 99.14 pct identical to residues 1 to 117 of 283 from GenPept : >gb|AAB18535.2| (U00039) orfB in IS150 [Escherichia coli]; IS150 orfB 506781 1076935 S0498 Shigella flexneri 2a str. 2457T IS150 orfB NP_836208.1 506350 D 198215 CDS NP_836209.1 30062038 1076797 507298..507450 1 NC_004741.1 residues 1 to 50 of 50 are 95.99 pct identical to residues 34 to 83 of 83 from GenPept : >gb|AAG54916.1|AE005238_2 (AE005238) Z0722 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 507450 1076797 S0499 Shigella flexneri 2a str. 2457T hypothetical protein NP_836209.1 507298 D 198215 CDS NP_836210.1 30062039 1080978 507702..507953 1 NC_004741.1 residues 1 to 83 of 83 are 97.59 pct identical to residues 1 to 83 of 83 from GenPept : >gb|AAG54916.1|AE005238_2 (AE005238) Z0722 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 507953 1080978 S0500 Shigella flexneri 2a str. 2457T hypothetical protein NP_836210.1 507702 D 198215 CDS NP_836211.1 30062040 1076936 complement(508075..508704) 1 NC_004741.1 residues 1 to 209 of 209 are 87.55 pct identical to residues 1 to 209 of 209 from Escherichia coli K-12 : B0583; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex 508704 entD 1076936 entD Shigella flexneri 2a str. 2457T phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex NP_836211.1 508075 R 198215 CDS NP_836212.1 30062041 1076938 complement(508870..511110) 1 NC_004741.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 511110 fepA 1076938 fepA Shigella flexneri 2a str. 2457T outer membrane receptor FepA NP_836212.1 508870 R 198215 CDS NP_836213.1 30062042 1076939 511353..512555 1 NC_004741.1 residues 27 to 400 of 400 are 98.12 pct identical to residues 1 to 374 of 374 from Escherichia coli K-12 : B0585; enterobactin/ferric enterobactin esterase 512555 fes 1076939 fes Shigella flexneri 2a str. 2457T enterobactin/ferric enterobactin esterase NP_836213.1 511353 D 198215 CDS NP_836214.1 30062043 1076940 512773..516618 1 NC_004741.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 516618 entF 1076940 entF Shigella flexneri 2a str. 2457T enterobactin synthase subunit F NP_836214.1 512773 D 198215 CDS NP_836215.1 30062044 1080988 516702..516977 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 516977 1080988 S0505 Shigella flexneri 2a str. 2457T IS1 orfA NP_836215.1 516702 D 198215 CDS NP_836216.1 30062045 1076572 516896..517399 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 517399 1076572 S0506 Shigella flexneri 2a str. 2457T IS1 orfB NP_836216.1 516896 D 198215 CDS NP_836217.1 30062046 1076943 complement(518740..519555) 1 NC_004741.1 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein 519555 fepC 1076943 fepC Shigella flexneri 2a str. 2457T iron-enterobactin transporter ATP-binding protein NP_836217.1 518740 R 198215 CDS NP_836218.1 30062047 1076944 complement(519552..520544) 1 NC_004741.1 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease 520544 fepG 1076944 fepG Shigella flexneri 2a str. 2457T iron-enterobactin transporter permease NP_836218.1 519552 R 198215 CDS NP_836219.1 30062048 1076945 complement(520541..521557) 1 NC_004741.1 with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein 521557 fepD 1076945 fepD Shigella flexneri 2a str. 2457T iron-enterobactin transporter membrane protein NP_836219.1 520541 R 198215 CDS NP_836220.1 30062049 1076946 521656..522888 1 NC_004741.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 522888 ybdA 1076946 ybdA Shigella flexneri 2a str. 2457T enterobactin exporter EntS NP_836220.1 521656 D 198215 CDS NP_836221.1 30062050 1076947 complement(522892..523848) 1 NC_004741.1 with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein 523848 fepB 1076947 fepB Shigella flexneri 2a str. 2457T iron-enterobactin transporter periplasmic binding protein NP_836221.1 522892 R 198215 CDS NP_836222.1 30062051 1076948 525325..526935 1 NC_004741.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 526935 entE 1076948 entE Shigella flexneri 2a str. 2457T enterobactin synthase subunit E NP_836222.1 525325 D 198215 CDS NP_836223.1 30062052 1076949 526949..527806 1 NC_004741.1 residues 1 to 285 of 285 are 99.64 pct identical to residues 1 to 285 of 285 from Escherichia coli K-12 : B0595; 2,3-dihydro-2,3-dihydroxybenzoate synthetase 527806 entB 1076949 entB Shigella flexneri 2a str. 2457T 2,3-dihydro-2,3-dihydroxybenzoate synthetase NP_836223.1 526949 D 198215 CDS NP_836224.1 30062053 1076950 527806..528552 1 NC_004741.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 528552 entA 1076950 entA Shigella flexneri 2a str. 2457T 2,3-dihydroxybenzoate-2,3-dehydrogenase NP_836224.1 527806 D 198215 CDS NP_836225.1 30062054 1076951 528555..528968 1 NC_004741.1 residues 1 to 137 of 137 are 90.51 pct identical to residues 1 to 137 of 137 from Escherichia coli K-12 : B0597; hypothetical protein 528968 ybdB 1076951 ybdB Shigella flexneri 2a str. 2457T hypothetical protein NP_836225.1 528555 D 198215 CDS NP_836226.1 30062055 1076952 529149..531254 1 NC_004741.1 residues 1 to 701 of 701 are 90.58 pct identical to residues 1 to 701 of 701 from Escherichia coli K-12 : B0598; carbon starvation protein 531254 cstA 1076952 cstA Shigella flexneri 2a str. 2457T carbon starvation protein NP_836226.1 529149 D 198215 CDS NP_836227.1 30062056 1076953 complement(531643..532731) 1 NC_004741.1 member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein 532731 ybdH 1076953 ybdH Shigella flexneri 2a str. 2457T hypothetical protein NP_836227.1 531643 R 198215 CDS NP_836228.1 30062057 1076954 532840..534000 1 NC_004741.1 catalyzes the transfer of an amino moiety; aminotransferase 534000 ybdL 1076954 ybdL Shigella flexneri 2a str. 2457T aminotransferase NP_836228.1 532840 D 198215 CDS NP_836229.1 30062058 1076956 complement(534520..535146) 1 NC_004741.1 residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB 535146 1076956 S0522 Shigella flexneri 2a str. 2457T IS911 orfB NP_836229.1 534520 R 198215 CDS NP_836230.1 30062059 1076958 complement(535386..535688) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 535688 1076958 S0523 Shigella flexneri 2a str. 2457T IS911 orfA NP_836230.1 535386 R 198215 CDS NP_836231.1 30062060 1076960 536938..537216 1 NC_004741.1 residues 1 to 92 of 92 are 92.39 pct identical to residues 3 to 94 of 94 from GenPept : >gb|AAG53987.1|AF327445_1 (AF327445) transposase A [Pantoea agglomerans]; ISEhe3 orfA 537216 1076960 S0526 Shigella flexneri 2a str. 2457T ISEhe3 orfA NP_836231.1 536938 D 198215 CDS NP_836232.1 30062061 1076961 537273..538085 1 NC_004741.1 residues 1 to 270 of 270 are 95.92 pct identical to residues 10 to 279 of 279 from GenPept : >gb|AAG53988.1|AF327445_2 (AF327445) transposase B [Pantoea agglomerans]; ISEhe3 orfB 538085 1076961 S0527 Shigella flexneri 2a str. 2457T ISEhe3 orfB NP_836232.1 537273 D 198215 CDS NP_836233.2 161486532 1076962 complement(539566..540312) 1 NC_004741.1 Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase 540312 dsbG 1076962 dsbG Shigella flexneri 2a str. 2457T disulfide isomerase/thiol-disulfide oxidase NP_836233.2 539566 R 198215 CDS NP_836234.1 30062063 1076966 540684..541247 1 NC_004741.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase subunit C 541247 ahpC 1076966 ahpC Shigella flexneri 2a str. 2457T alkyl hydroperoxide reductase subunit C NP_836234.1 540684 D 198215 CDS NP_836235.1 30062064 1078851 541462..543057 1 NC_004741.1 residues 1 to 531 of 531 are 95.29 pct identical to residues 1 to 531 of 531 from Escherichia coli K-12 : B0606; involved in detoxification of hydroperoxides; alkyl hydroperoxide reductase, F52a subunit 543057 ahpF 1078851 ahpF Shigella flexneri 2a str. 2457T alkyl hydroperoxide reductase, F52a subunit NP_836235.1 541462 D 198215 CDS NP_836236.1 30062065 1076967 complement(543178..543606) 1 NC_004741.1 residues 1 to 142 of 142 are 98.59 pct identical to residues 1 to 142 of 142 from Escherichia coli K-12 : B0607; hypothetical protein 543606 ybdQ 1076967 ybdQ Shigella flexneri 2a str. 2457T hypothetical protein NP_836236.1 543178 R 198215 CDS NP_836237.1 30062066 1076968 543827..545065 1 NC_004741.1 residues 1 to 412 of 412 are 98.78 pct identical to residues 1 to 412 of 412 from Escherichia coli K-12 : B0608; oxidoreductase 545065 ybdR 1076968 ybdR Shigella flexneri 2a str. 2457T oxidoreductase NP_836237.1 543827 D 198215 CDS NP_836238.1 30062067 1076969 545146..545607 1 NC_004741.1 residues 1 to 147 of 147 are 100.00 pct identical to residues 7 to 153 of 153 from Escherichia coli K-12 : B0609; hypothetical protein 545607 1076969 S0533 Shigella flexneri 2a str. 2457T hypothetical protein NP_836238.1 545146 D 198215 CDS NP_836239.1 30062068 1076970 complement(545296..545706) 1 NC_004741.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 545706 rnk 1076970 rnk Shigella flexneri 2a str. 2457T nucleoside diphosphate kinase regulator NP_836239.1 545296 R 198215 CDS NP_836240.1 30062069 1076971 complement(545935..546759) 1 NC_004741.1 residues 7 to 274 of 274 are 91.79 pct identical to residues 1 to 268 of 268 from Escherichia coli K-12 : B0611; cleaves phosphodiester bond between any two nucleotides; ribonuclease I 546759 rna 1076971 rna Shigella flexneri 2a str. 2457T ribonuclease I NP_836240.1 545935 R 198215 CDS NP_836241.1 30062070 1076973 complement(548368..549246) 1 NC_004741.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase 549246 citG 1076973 citG Shigella flexneri 2a str. 2457T triphosphoribosyl-dephospho-CoA synthase NP_836241.1 548368 R 198215 CDS NP_836242.1 30062071 1076974 complement(549283..549771) 1 NC_004741.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase 549771 citX 1076974 citX Shigella flexneri 2a str. 2457T 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase NP_836242.1 549283 R 198215 CDS NP_836243.1 30062072 1078027 complement(549775..551307) 1 NC_004741.1 residues 1 to 510 of 510 are 99.01 pct identical to residues 1 to 510 of 510 from Escherichia coli K-12 : B0615; citrate lyase subunit alpha 551307 citF 1078027 citF Shigella flexneri 2a str. 2457T citrate lyase subunit alpha NP_836243.1 549775 R 198215 CDS NP_836244.1 30062073 1076975 complement(551318..552226) 1 NC_004741.1 residues 1 to 302 of 302 are 95.36 pct identical to residues 6 to 307 of 307 from Escherichia coli K-12 : B0616; citrate lyase beta chain (acyl lyase subunit) 552226 citE 1076975 citE Shigella flexneri 2a str. 2457T citrate lyase beta chain (acyl lyase subunit) NP_836244.1 551318 R 198215 CDS NP_836245.1 30062074 1076976 complement(552223..552519) 1 NC_004741.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 552519 citD 1076976 citD Shigella flexneri 2a str. 2457T citrate lyase subunit gamma NP_836245.1 552223 R 198215 CDS NP_836246.1 30062075 1076978 complement(552534..553679) 1 NC_004741.1 residues 1 to 381 of 381 are 99.47 pct identical to residues 1 to 381 of 381 from Escherichia coli K-12 : B0618; citrate lyase synthetase (citrate (pro-3S)-lyase ligase 553679 citC 1076978 citC Shigella flexneri 2a str. 2457T citrate lyase synthetase (citrate (pro-3S)-lyase ligase NP_836246.1 552534 R 198215 CDS NP_836247.1 30062076 1076979 complement(554059..554562) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 554562 1076979 S0543 Shigella flexneri 2a str. 2457T IS1 orfB NP_836247.1 554059 R 198215 CDS NP_836248.1 30062077 1076980 complement(554481..554756) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 554756 1076980 S0545 Shigella flexneri 2a str. 2457T IS1 orfA NP_836248.1 554481 R 198215 CDS NP_836249.1 30062078 1078907 555625..556443 1 NC_004741.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase 556443 ybhA 1078907 ybhA Shigella flexneri 2a str. 2457T phosphotransferase NP_836249.1 555625 D 198215 CDS NP_836250.1 30062079 1076981 complement(556444..557502) 1 NC_004741.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 557502 modC 1076981 modC Shigella flexneri 2a str. 2457T molybdate transporter ATP-binding protein NP_836250.1 556444 R 198215 CDS NP_836251.1 30062080 1076982 complement(557505..558194) 1 NC_004741.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 558194 modB 1076982 modB Shigella flexneri 2a str. 2457T molybdate ABC transporter permease NP_836251.1 557505 R 198215 CDS NP_836252.1 30062081 1076983 complement(558194..558967) 1 NC_004741.1 with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 558967 modA 1076983 modA Shigella flexneri 2a str. 2457T molybdate transporter periplasmic protein NP_836252.1 558194 R 198215 CDS NP_836253.1 30062082 1076984 complement(559134..559283) 1 NC_004741.1 residues 1 to 49 of 49 are 71.42 pct identical to residues 1 to 49 of 49 from Escherichia coli K-12 : B0762; hypothetical protein 559283 1076984 S0550 Shigella flexneri 2a str. 2457T hypothetical protein NP_836253.1 559134 R 198215 CDS NP_836254.1 30062083 1076985 559412..560200 1 NC_004741.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 560200 modE 1076985 modE Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator ModE NP_836254.1 559412 D 198215 CDS NP_836255.1 30062084 1076986 560268..561740 1 NC_004741.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF 561740 modF 1076986 modF Shigella flexneri 2a str. 2457T molybdenum transport ATP-binding protein ModF NP_836255.1 560268 D 198215 CDS NP_836256.1 30062085 1076987 562001..563017 1 NC_004741.1 residues 1 to 338 of 338 are 99.11 pct identical to residues 1 to 338 of 338 from Escherichia coli K-12 : B0759; UDP-galactose-4-epimerase 563017 galE 1076987 galE Shigella flexneri 2a str. 2457T UDP-galactose-4-epimerase NP_836256.1 562001 D 198215 CDS NP_836257.1 30062086 1076988 563027..564073 1 NC_004741.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 564073 galT 1076988 galT Shigella flexneri 2a str. 2457T galactose-1-phosphate uridylyltransferase NP_836257.1 563027 D 198215 CDS NP_836258.1 30062087 1076989 564077..565225 1 NC_004741.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 565225 galK 1076989 galK Shigella flexneri 2a str. 2457T galactokinase NP_836258.1 564077 D 198215 CDS NP_836259.1 30062088 1076990 565219..566259 1 NC_004741.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 566259 galM 1076990 galM Shigella flexneri 2a str. 2457T aldose 1-epimerase NP_836259.1 565219 D 198215 CDS NP_836260.1 30062089 1076992 566462..567214 1 NC_004741.1 catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 567214 gpmA 1076992 gpmA Shigella flexneri 2a str. 2457T phosphoglyceromutase NP_836260.1 566462 D 198215 CDS NP_836261.1 30062090 1076993 complement(567381..568433) 1 NC_004741.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 568433 aroG 1076993 aroG Shigella flexneri 2a str. 2457T phospho-2-dehydro-3-deoxyheptonate aldolase NP_836261.1 567381 R 198215 CDS NP_836262.1 30062091 1076994 568749..569129 1 NC_004741.1 residues 1 to 126 of 126 are 65.07 pct identical to residues 1 to 126 of 126 from Escherichia coli K-12 : B0753; homeobox protein 569129 1076994 S0559 Shigella flexneri 2a str. 2457T homeobox protein NP_836262.1 568749 D 198215 CDS NP_836263.1 30062092 1079579 569243..570184 1 NC_004741.1 involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 570184 ybgR 1079579 ybgR Shigella flexneri 2a str. 2457T zinc transporter ZitB NP_836263.1 569243 D 198215 CDS NP_836264.1 30062093 1076995 complement(570181..570900) 1 NC_004741.1 residues 1 to 239 of 239 are 100.00 pct identical to residues 1 to 239 of 239 from Escherichia coli K-12 : B0751; required for NMN transport; PnuC protein 570900 pnuC 1076995 pnuC Shigella flexneri 2a str. 2457T PnuC protein NP_836264.1 570181 R 198215 CDS NP_836265.1 30062094 1076997 complement(570938..571981) 1 NC_004741.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 571981 nadA 1076997 nadA Shigella flexneri 2a str. 2457T quinolinate synthetase NP_836265.1 570938 R 198215 CDS NP_836266.1 30062095 1077006 complement(572965..573756) 1 NC_004741.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 573756 ybgF 1077006 ybgF Shigella flexneri 2a str. 2457T tol-pal system protein YbgF NP_836266.1 572965 R 198215 CDS NP_836267.1 30062096 1077007 complement(573766..574287) 1 NC_004741.1 residues 1 to 173 of 173 are 93.64 pct identical to residues 1 to 173 of 173 from Escherichia coli K-12 : B0741; peptidoglycan-associated outer membrane lipoprotein 574287 pal 1077007 pal Shigella flexneri 2a str. 2457T peptidoglycan-associated outer membrane lipoprotein NP_836267.1 573766 R 198215 CDS NP_836268.1 30062097 1076964 complement(574322..575614) 1 NC_004741.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 575614 tolB 1076964 tolB Shigella flexneri 2a str. 2457T translocation protein TolB NP_836268.1 574322 R 198215 CDS NP_836269.1 30062098 1077008 complement(575747..576988) 1 NC_004741.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 576988 tolA 1077008 tolA Shigella flexneri 2a str. 2457T cell envelope integrity inner membrane protein TolA NP_836269.1 575747 R 198215 CDS NP_836270.1 30062099 1077009 complement(577053..577481) 1 NC_004741.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 577481 tolR 1077009 tolR Shigella flexneri 2a str. 2457T colicin uptake protein TolR NP_836270.1 577053 R 198215 CDS NP_836271.1 30062100 1077010 complement(577485..578177) 1 NC_004741.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 578177 tolQ 1077010 tolQ Shigella flexneri 2a str. 2457T colicin uptake protein TolQ NP_836271.1 577485 R 198215 CDS NP_836272.1 30062101 1077011 complement(578174..578578) 1 NC_004741.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase YbgC 578578 ybgC 1077011 ybgC Shigella flexneri 2a str. 2457T acyl-CoA thioester hydrolase YbgC NP_836272.1 578174 R 198215 CDS NP_836273.1 30062102 1077012 complement(578728..579021) 1 NC_004741.1 residues 1 to 93 of 97 are 100.00 pct identical to residues 1 to 93 of 97 from Escherichia coli K-12 : B0735; hypothetical protein 579021 ybgE 1077012 ybgE Shigella flexneri 2a str. 2457T hypothetical protein NP_836273.1 578728 R 198215 CDS NP_836274.1 30062103 1080352 complement(579149..580288) 1 NC_004741.1 residues 1 to 379 of 379 are 92.61 pct identical to residues 1 to 379 of 379 from Escherichia coli K-12 : B0734; cytochrome d terminal oxidase polypeptide subunit II 580288 cydB 1080352 cydB Shigella flexneri 2a str. 2457T cytochrome d terminal oxidase polypeptide subunit II NP_836274.1 579149 R 198215 CDS NP_836275.1 30062104 1077013 complement(580304..581875) 1 NC_004741.1 residues 1 to 523 of 523 are 99.80 pct identical to residues 1 to 523 of 523 from Escherichia coli K-12 : B0733; cytochrome d terminal oxidase, polypeptide subunit I 581875 cydA 1077013 cydA Shigella flexneri 2a str. 2457T cytochrome d terminal oxidase, polypeptide subunit I NP_836275.1 580304 R 198215 CDS NP_836276.1 30062105 1077014 complement(582720..585353) 1 NC_004741.1 residues 1 to 877 of 877 are 93.84 pct identical to residues 1 to 877 of 877 from Escherichia coli K-12 : B0732; alpha-mannosidase 585353 ybgG 1077014 ybgG Shigella flexneri 2a str. 2457T alpha-mannosidase NP_836276.1 582720 R 198215 CDS NP_836277.1 30062106 1077015 complement(585371..587347) 1 NC_004741.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; 2-O-a-mannosyl-D-glycerate specific PTS transporten components IIABC 587347 hrsA 1077015 hrsA Shigella flexneri 2a str. 2457T 2-O-a-mannosyl-D-glycerate specific PTS transporten components IIABC NP_836277.1 585371 R 198215 CDS NP_836278.1 30062107 1077016 587457..588401 1 NC_004741.1 regulates the succiny-lCoA synthetase operon; DNA-binding transcriptional repressor MngR 588401 farR 1077016 farR Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor MngR NP_836278.1 587457 D 198215 CDS NP_836279.1 30062108 1079055 complement(588283..589152) 1 NC_004741.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 589152 sucD 1079055 sucD Shigella flexneri 2a str. 2457T succinyl-CoA synthetase subunit alpha NP_836279.1 588283 R 198215 CDS NP_836280.1 30062109 1077017 complement(589152..590318) 1 NC_004741.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 590318 sucC 1077017 sucC Shigella flexneri 2a str. 2457T succinyl-CoA synthetase subunit beta NP_836280.1 589152 R 198215 CDS NP_836281.1 30062110 1077019 complement(590412..591629) 1 NC_004741.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 591629 sucB 1077019 sucB Shigella flexneri 2a str. 2457T dihydrolipoamide succinyltransferase NP_836281.1 590412 R 198215 CDS NP_836282.1 30062111 1077020 complement(591644..594445) 1 NC_004741.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 594445 sucA 1077020 sucA Shigella flexneri 2a str. 2457T 2-oxoglutarate dehydrogenase E1 component NP_836282.1 591644 R 198215 CDS NP_836283.1 30062112 1077021 complement(594427..594687) 1 NC_004741.1 residues 1 to 86 of 86 are 100.00 pct identical to residues 1 to 86 of 86 from Escherichia coli K-12 : B0725; hypothetical protein 594687 1077021 S0585 Shigella flexneri 2a str. 2457T hypothetical protein NP_836283.1 594427 R 198215 CDS NP_836284.1 30062113 1076493 complement(594746..595462) 1 NC_004741.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 595462 sdhB 1076493 sdhB Shigella flexneri 2a str. 2457T succinate dehydrogenase iron-sulfur subunit NP_836284.1 594746 R 198215 CDS NP_836285.1 30062114 1079049 complement(595478..597244) 1 NC_004741.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 597244 sdhA 1079049 sdhA Shigella flexneri 2a str. 2457T succinate dehydrogenase flavoprotein subunit NP_836285.1 595478 R 198215 CDS NP_836286.1 30062115 1077022 complement(597244..597591) 1 NC_004741.1 residues 1 to 94 of 115 are 100.00 pct identical to residues 1 to 94 of 115 from Escherichia coli K-12 : B0722; succinate dehydrogenase cytochrome b556 small membrane subunit 597591 sdhD 1077022 sdhD Shigella flexneri 2a str. 2457T succinate dehydrogenase cytochrome b556 small membrane subunit NP_836286.1 597244 R 198215 CDS NP_836287.2 161486531 1077024 complement(597585..597974) 1 NC_004741.1 residues 6 to 134 of 134 are 99.22 pct identical to residues 1 to 129 of 129 from Escherichia coli K-12 : B0721; succinate dehydrogenase cytochrome b556 large membrane subunit 597974 sdhC 1077024 sdhC Shigella flexneri 2a str. 2457T succinate dehydrogenase cytochrome b556 large membrane subunit NP_836287.2 597585 R 198215 CDS NP_836288.1 30062117 1079972 598683..599966 1 NC_004741.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 599966 gltA 1079972 gltA Shigella flexneri 2a str. 2457T type II citrate synthase NP_836288.1 598683 D 198215 CDS NP_836289.1 30062118 1077025 600357..600923 1 NC_004741.1 residues 1 to 188 of 188 are 76.06 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 : B0719; fimbrial-like protein 600923 ybgD 1077025 ybgD Shigella flexneri 2a str. 2457T fimbrial-like protein NP_836289.1 600357 D 198215 CDS NP_836290.1 30062119 1077026 600974..603433 1 NC_004741.1 residues 1 to 819 of 819 are 93.16 pct identical to residues 1 to 818 of 818 from Escherichia coli K-12 : B0718; outer membrane protein 603433 ybgQ 1077026 ybgQ Shigella flexneri 2a str. 2457T outer membrane protein NP_836290.1 600974 D 198215 CDS NP_836291.1 30062120 1077027 603448..604179 1 NC_004741.1 residues 1 to 242 of 243 are 87.19 pct identical to residues 1 to 242 of 242 from Escherichia coli K-12 : B0717; chaperone 604179 ybgP 1077027 ybgP Shigella flexneri 2a str. 2457T chaperone NP_836291.1 603448 D 198215 CDS NP_836292.1 30062121 1076462 605359..606450 1 NC_004741.1 residues 1 to 363 of 363 are 95.59 pct identical to residues 1 to 363 of 363 from Escherichia coli K-12 : B0715; transporter 606450 abrB 1076462 abrB Shigella flexneri 2a str. 2457T transporter NP_836292.1 605359 D 198215 CDS NP_836293.1 30062122 1077029 complement(606447..607238) 1 NC_004741.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 607238 nei 1077029 nei Shigella flexneri 2a str. 2457T endonuclease VIII NP_836293.1 606447 R 198215 CDS NP_836294.1 30062123 1076835 complement(607274..608008) 1 NC_004741.1 residues 1 to 244 of 244 are 92.62 pct identical to residues 1 to 244 of 244 from Escherichia coli K-12 : B0713; LamB/YcsF family protein 608008 ybgL 1076835 ybgL Shigella flexneri 2a str. 2457T LamB/YcsF family protein NP_836294.1 607274 R 198215 CDS NP_836295.1 30062124 1077031 complement(608924..609580) 1 NC_004741.1 residues 1 to 218 of 218 are 99.08 pct identical to residues 1 to 218 of 218 from Escherichia coli K-12 : B0711; carboxylase 609580 ybgJ 1077031 ybgJ Shigella flexneri 2a str. 2457T carboxylase NP_836295.1 608924 R 198215 CDS NP_836296.1 30062125 1077032 complement(609603..610346) 1 NC_004741.1 residues 1 to 247 of 247 are 94.73 pct identical to residues 1 to 247 of 247 from Escherichia coli K-12 : B0710; hydrolase-oxidase 610346 ybgI 1077032 ybgI Shigella flexneri 2a str. 2457T hydrolase-oxidase NP_836296.1 609603 R 198215 CDS NP_836297.1 30062126 1077033 610617..612098 1 NC_004741.1 residues 1 to 493 of 493 are 97.16 pct identical to residues 1 to 493 of 493 from Escherichia coli K-12 : B0709; transporter 612098 ybgH 1077033 ybgH Shigella flexneri 2a str. 2457T transporter NP_836297.1 610617 D 198215 CDS NP_836298.1 30062127 1077023 complement(612248..613666) 1 NC_004741.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 613666 phrB 1077023 phrB Shigella flexneri 2a str. 2457T deoxyribodipyrimidine photolyase NP_836298.1 612248 R 198215 CDS NP_836299.1 30062128 1077034 complement(613663..614172) 1 NC_004741.1 residues 1 to 169 of 169 are 98.81 pct identical to residues 1 to 169 of 169 from Escherichia coli K-12 : B0707; hypothetical protein 614172 ybgA 1077034 ybgA Shigella flexneri 2a str. 2457T hypothetical protein NP_836299.1 613663 R 198215 CDS NP_836300.1 30062129 1077035 614301..614588 1 NC_004741.1 no significant similarities; hypothetical protein 614588 1077035 S0604 Shigella flexneri 2a str. 2457T hypothetical protein NP_836300.1 614301 D 198215 CDS NP_836301.1 30062130 1077036 complement(615026..618412) 1 NC_004741.1 residues 702 to 1008 of 1128 are 59.29 pct identical to residues 524 to 822 of 843 from GenPept : >emb|CAD08754.1| (AL627266) Rhs-family protein [Salmonella enterica subsp. enterica serovar Typhi]; Rhs-family protein 618412 rhsE 1077036 rhsE Shigella flexneri 2a str. 2457T Rhs-family protein NP_836301.1 615026 R 198215 CDS NP_836302.1 30062131 1077045 complement(619028..619531) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 619531 1077045 S0606 Shigella flexneri 2a str. 2457T IS1 orfB NP_836302.1 619028 R 198215 CDS NP_836303.1 30062132 1080996 complement(619450..619734) 1 NC_004741.1 residues 1 to 94 of 94 are 79.78 pct identical to residues 1 to 94 of 94 from GenPept : >gb|AAF70018.1|AF250878_179 (AF250878) IS1 transposase [Salmonella typhi]; IS1 orfA 619734 1080996 S0607 Shigella flexneri 2a str. 2457T IS1 orfA NP_836303.1 619450 R 198215 CDS NP_836304.1 30062133 1077037 complement(620220..620426) 1 NC_004741.1 residues 1 to 68 of 68 are 100.00 pct identical to residues 1 to 68 of 68 from Escherichia coli K-12 : B0699; hypothetical protein 620426 ybfA 1077037 ybfA Shigella flexneri 2a str. 2457T hypothetical protein NP_836304.1 620220 R 198215 CDS NP_836305.1 30062134 1077038 620828..622501 1 NC_004741.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 622501 kdpA 1077038 kdpA Shigella flexneri 2a str. 2457T potassium-transporting ATPase subunit A NP_836305.1 620828 D 198215 CDS NP_836306.1 30062135 1077040 624580..625152 1 NC_004741.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 625152 kdpC 1077040 kdpC Shigella flexneri 2a str. 2457T potassium-transporting ATPase subunit C NP_836306.1 624580 D 198215 CDS NP_836307.1 30062136 1078494 631391..632710 1 NC_004741.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 632710 potE 1078494 potE Shigella flexneri 2a str. 2457T putrescine transporter NP_836307.1 631391 D 198215 CDS NP_836308.1 30062137 1077044 complement(632766..634406) 1 NC_004741.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 634406 pgm 1077044 pgm Shigella flexneri 2a str. 2457T phosphoglucomutase NP_836308.1 632766 R 198215 CDS NP_836309.1 30062138 1077046 complement(634432..634977) 1 NC_004741.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 634977 seqA 1077046 seqA Shigella flexneri 2a str. 2457T replication initiation regulator SeqA NP_836309.1 634432 R 198215 CDS NP_836310.1 30062139 1077047 635162..635926 1 NC_004741.1 residues 1 to 254 of 254 are 98.81 pct identical to residues 1 to 254 of 254 from Escherichia coli K-12 : B0686; hypothetical protein 635926 ybfF 1077047 ybfF Shigella flexneri 2a str. 2457T hypothetical protein NP_836310.1 635162 D 198215 CDS NP_836311.1 30062140 1077048 635997..636359 1 NC_004741.1 residues 1 to 120 of 120 are 85.00 pct identical to residues 1 to 120 of 120 from Escherichia coli K-12 : B0685; LexA regulated protein 636359 ybfE 1077048 ybfE Shigella flexneri 2a str. 2457T LexA regulated protein NP_836311.1 635997 D 198215 CDS NP_836312.1 30062141 1077053 636499..637029 1 NC_004741.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 637029 fldA 1077053 fldA Shigella flexneri 2a str. 2457T flavodoxin FldA NP_836312.1 636499 D 198215 CDS NP_836313.1 30062142 1077049 637318..637764 1 NC_004741.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 637764 fur 1077049 fur Shigella flexneri 2a str. 2457T ferric uptake regulator NP_836313.1 637318 D 198215 CDS NP_836314.1 30062143 1077050 complement(637848..638174) 1 NC_004741.1 residues 1 to 108 of 108 are 98.14 pct identical to residues 1 to 108 of 108 from Escherichia coli K-12 : B0682; hypothetical protein 638174 ybfN 1077050 ybfN Shigella flexneri 2a str. 2457T hypothetical protein NP_836314.1 637848 R 198215 CDS NP_836315.1 30062144 1077051 complement(638211..639617) 1 NC_004741.1 residues 1 to 468 of 468 are 99.14 pct identical to residues 1 to 468 of 468 from Escherichia coli K-12 : B0681; hypothetical protein 639617 ybfM 1077051 ybfM Shigella flexneri 2a str. 2457T hypothetical protein NP_836315.1 638211 R 198215 CDS NP_836316.1 30062145 1077052 complement(640196..641860) 1 NC_004741.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 641860 glnS 1077052 glnS Shigella flexneri 2a str. 2457T glutaminyl-tRNA synthetase NP_836316.1 640196 R 198215 CDS NP_836317.1 30062146 1077054 complement(642063..644009) 1 NC_004741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; N-acetyl glucosamine specific PTS system components IIABC 644009 nagE 1077054 nagE Shigella flexneri 2a str. 2457T N-acetyl glucosamine specific PTS system components IIABC NP_836317.1 642063 R 198215 CDS NP_836318.1 30062147 1077056 644342..645142 1 NC_004741.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 645142 nagB 1077056 nagB Shigella flexneri 2a str. 2457T glucosamine-6-phosphate deaminase NP_836318.1 644342 D 198215 CDS NP_836319.1 30062148 1077057 645202..646350 1 NC_004741.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 646350 nagA 1077057 nagA Shigella flexneri 2a str. 2457T N-acetylglucosamine-6-phosphate deacetylase NP_836319.1 645202 D 198215 CDS NP_836320.1 30062149 1077058 646359..647579 1 NC_004741.1 residues 1 to 406 of 406 are 100.00 pct identical to residues 1 to 406 of 406 from Escherichia coli K-12 : B0676; transcriptional repressor of nag (N-acetylglucosamine) operon 647579 nagC 1077058 nagC Shigella flexneri 2a str. 2457T transcriptional repressor of nag (N-acetylglucosamine) operon NP_836320.1 646359 D 198215 CDS NP_836321.1 30062150 1077060 648776..650440 1 NC_004741.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 650440 asnB 1077060 asnB Shigella flexneri 2a str. 2457T asparagine synthetase B NP_836321.1 648776 D 198215 CDS NP_836322.1 30062151 1077070 complement(651676..652851) 1 NC_004741.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 652851 ubiF 1077070 ubiF Shigella flexneri 2a str. 2457T 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase NP_836322.1 651676 R 198215 CDS NP_836323.1 30062152 1077071 652997..654421 1 NC_004741.1 residues 1 to 474 of 474 are 99.78 pct identical to residues 1 to 474 of 474 from Escherichia coli K-12 : B0661; hypothetical protein 654421 yleA 1077071 yleA Shigella flexneri 2a str. 2457T hypothetical protein NP_836323.1 652997 D 198215 CDS NP_836324.1 30062153 1077072 654535..655614 1 NC_004741.1 residues 1 to 336 of 359 are 100.00 pct identical to residues 1 to 336 of 359 from Escherichia coli K-12 : B0660; ATP-binding protein in pho regulon 655614 ybeZ 1077072 ybeZ Shigella flexneri 2a str. 2457T ATP-binding protein in pho regulon NP_836324.1 654535 D 198215 CDS NP_836325.1 30062154 1077074 655611..656078 1 NC_004741.1 residues 1 to 155 of 155 are 88.38 pct identical to residues 1 to 155 of 155 from Escherichia coli K-12 : B0659; metalloprotease 656078 ybeY 1077074 ybeY Shigella flexneri 2a str. 2457T metalloprotease NP_836325.1 655611 D 198215 CDS NP_836326.1 30062155 1077075 656168..657046 1 NC_004741.1 residues 1 to 292 of 292 are 95.54 pct identical to residues 1 to 292 of 292 from Escherichia coli K-12 : B0658; transporter 657046 ybeX 1077075 ybeX Shigella flexneri 2a str. 2457T transporter NP_836326.1 656168 D 198215 CDS NP_836327.1 30062156 1077076 657071..658609 1 NC_004741.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 658609 lnt 1077076 lnt Shigella flexneri 2a str. 2457T apolipoprotein N-acyltransferase NP_836327.1 657071 D 198215 CDS NP_836328.1 30062157 1079280 659005..659913 1 NC_004741.1 residues 1 to 302 of 302 are 89.73 pct identical to residues 1 to 302 of 302 from Escherichia coli K-12 : B0655; glutamate and aspartate transporter subunit 659913 ybeJ 1079280 ybeJ Shigella flexneri 2a str. 2457T glutamate and aspartate transporter subunit NP_836328.1 659005 D 198215 CDS NP_836329.1 30062158 1077077 660083..660823 1 NC_004741.1 residues 1 to 246 of 246 are 99.18 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B0654; glutamate/aspartate transport system permease 660823 gltJ 1077077 gltJ Shigella flexneri 2a str. 2457T glutamate/aspartate transport system permease NP_836329.1 660083 D 198215 CDS NP_836330.1 30062159 1077078 660823..661497 1 NC_004741.1 residues 1 to 224 of 224 are 99.55 pct identical to residues 1 to 224 of 224 from Escherichia coli K-12 : B0653; glutamate/aspartate transport system permease 661497 gltK 1077078 gltK Shigella flexneri 2a str. 2457T glutamate/aspartate transport system permease NP_836330.1 660823 D 198215 CDS NP_836331.1 30062160 1077079 661497..662222 1 NC_004741.1 residues 1 to 241 of 241 are 94.60 pct identical to residues 1 to 241 of 241 from Escherichia coli K-12 : B0652; ATP-binding protein of glutamate/aspartate transport system 662222 gltL 1077079 gltL Shigella flexneri 2a str. 2457T ATP-binding protein of glutamate/aspartate transport system NP_836331.1 661497 D 198215 CDS NP_836332.1 30062161 1077080 662340..663275 1 NC_004741.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 663275 rihA 1077080 rihA Shigella flexneri 2a str. 2457T ribonucleoside hydrolase 1 NP_836332.1 662340 D 198215 CDS NP_836333.1 30062162 1077084 complement(665089..666540) 1 NC_004741.1 residues 1 to 483 of 483 are 92.13 pct identical to residues 1 to 483 of 483 from Escherichia coli K-12 : B0649; hypothetical protein 666540 ybeV 1077084 ybeV Shigella flexneri 2a str. 2457T hypothetical protein NP_836333.1 665089 R 198215 CDS NP_836334.1 30062163 1077085 complement(666537..667244) 1 NC_004741.1 residues 1 to 235 of 235 are 96.59 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B0648; tRNA ligase 667244 ybeU 1077085 ybeU Shigella flexneri 2a str. 2457T tRNA ligase NP_836334.1 666537 R 198215 CDS NP_836335.1 30062164 1077086 667346..667900 1 NC_004741.1 residues 1 to 184 of 184 are 97.28 pct identical to residues 1 to 184 of 184 from Escherichia coli K-12 : B0647; hypothetical protein 667900 ybeT 1077086 ybeT Shigella flexneri 2a str. 2457T hypothetical protein NP_836335.1 667346 D 198215 CDS NP_836336.1 30062165 1077088 complement(667910..669337) 1 NC_004741.1 residues 1 to 475 of 475 are 93.68 pct identical to residues 1 to 475 of 475 from Escherichia coli K-12 : B0646; involved in polynucleotide modification; enzyme 669337 ybeS 1077088 ybeS Shigella flexneri 2a str. 2457T enzyme NP_836336.1 667910 R 198215 CDS NP_836337.1 30062166 1077089 complement(669334..670041) 1 NC_004741.1 residues 1 to 235 of 235 are 93.19 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B0645; hypothetical protein 670041 ybeR 1077089 ybeR Shigella flexneri 2a str. 2457T hypothetical protein NP_836337.1 669334 R 198215 CDS NP_836338.1 30062167 1077090 670199..671182 1 NC_004741.1 residues 1 to 327 of 327 are 96.63 pct identical to residues 1 to 327 of 327 from Escherichia coli K-12 : B0644; hypothetical protein 671182 ybeQ 1077090 ybeQ Shigella flexneri 2a str. 2457T hypothetical protein NP_836338.1 670199 D 198215 CDS NP_836339.1 30062168 1077091 complement(671252..671734) 1 NC_004741.1 residues 1 to 160 of 160 are 97.50 pct identical to residues 1 to 160 of 160 from Escherichia coli K-12 : B0643; hypothetical protein 671734 ybeL 1077091 ybeL Shigella flexneri 2a str. 2457T hypothetical protein NP_836339.1 671252 R 198215 CDS NP_836340.1 30062169 1080411 671969..674551 1 NC_004741.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 674551 leuS 1080411 leuS Shigella flexneri 2a str. 2457T leucyl-tRNA synthetase NP_836340.1 671969 D 198215 CDS NP_836341.1 30062170 1077092 674566..675147 1 NC_004741.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 675147 rlpB 1077092 rlpB Shigella flexneri 2a str. 2457T LPS-assembly lipoprotein RlpB NP_836341.1 674566 D 198215 CDS NP_836342.1 30062171 1077093 675147..676178 1 NC_004741.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 676178 holA 1077093 holA Shigella flexneri 2a str. 2457T DNA polymerase III subunit delta NP_836342.1 675147 D 198215 CDS NP_836343.1 30062172 1077094 676180..676821 1 NC_004741.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 676821 nadD 1077094 nadD Shigella flexneri 2a str. 2457T nicotinic acid mononucleotide adenylyltransferase NP_836343.1 676180 D 198215 CDS NP_836344.1 30062173 1077087 676845..677456 1 NC_004741.1 residues 1 to 203 of 203 are 96.55 pct identical to residues 1 to 203 of 203 from Escherichia coli K-12 : B0638; alpha-ribazole phosphatase 677456 phpB 1077087 phpB Shigella flexneri 2a str. 2457T alpha-ribazole phosphatase NP_836344.1 676845 D 198215 CDS NP_836345.1 30062174 1077073 677824..678033 1 NC_004741.1 residues 1 to 69 of 69 are 100.00 pct identical to residues 1 to 69 of 69 from Escherichia coli K-12 : B0637; hypothetical protein 678033 ybeB 1077073 ybeB Shigella flexneri 2a str. 2457T hypothetical protein NP_836345.1 677824 D 198215 CDS NP_836346.1 30062175 1077097 678037..678504 1 NC_004741.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 678504 ybeA 1077097 ybeA Shigella flexneri 2a str. 2457T rRNA large subunit methyltransferase NP_836346.1 678037 D 198215 CDS NP_836347.1 30062176 1077098 678535..680436 1 NC_004741.1 residues 1 to 633 of 633 are 99.68 pct identical to residues 1 to 633 of 633 from Escherichia coli K-12 : B0635; involved in cell elongation, ephase; penicillin-binding protein 2 680436 mrdA 1077098 mrdA Shigella flexneri 2a str. 2457T penicillin-binding protein 2 NP_836347.1 678535 D 198215 CDS NP_836348.1 30062177 1077099 680439..681551 1 NC_004741.1 residues 1 to 370 of 370 are 80.81 pct identical to residues 1 to 370 of 370 from Escherichia coli K-12 : B0634; sensitiveto radiation and drugs; cell wall shape-determining protein 681551 mrdB 1077099 mrdB Shigella flexneri 2a str. 2457T cell wall shape-determining protein NP_836348.1 680439 D 198215 CDS NP_836349.1 30062178 1080410 681562..682650 1 NC_004741.1 residues 1 to 362 of 362 are 90.60 pct identical to residues 1 to 362 of 362 from Escherichia coli K-12 : B0633; rare lipoprotein A 682650 rlpA 1080410 rlpA Shigella flexneri 2a str. 2457T rare lipoprotein A NP_836349.1 681562 D 198215 CDS NP_836350.1 30062179 1077100 682789..684000 1 NC_004741.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase 684000 dacA 1077100 dacA Shigella flexneri 2a str. 2457T D-alanyl-D-alanine carboxypeptidase NP_836350.1 682789 D 198215 CDS NP_836351.1 30062180 1078112 684111..684374 1 NC_004741.1 residues 1 to 87 of 87 are 100.00 pct identical to residues 1 to 87 of 87 from Escherichia coli K-12 : B0631; hypothetical protein 684374 ybeD 1078112 ybeD Shigella flexneri 2a str. 2457T hypothetical protein NP_836351.1 684111 D 198215 CDS NP_836352.2 161486530 1077101 684475..685116 1 NC_004741.1 lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse; lipoate-protein ligase B; transfers lipoate to apolipoproteins; involved in lipoate metabolism; lipoyltransferase 685116 lipB 1077101 lipB Shigella flexneri 2a str. 2457T lipoyltransferase NP_836352.2 684475 D 198215 CDS NP_836353.1 30062182 1077102 685528..686328 1 NC_004741.1 residues 1 to 266 of 266 are 98.87 pct identical to residues 1 to 266 of 266 from Escherichia coli K-12 : B0629; DNA-binding transcriptional regulator 686328 ybeF 1077102 ybeF Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator NP_836353.1 685528 D 198215 CDS NP_836354.1 30062183 1077103 686537..687502 1 NC_004741.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 687502 lipA 1077103 lipA Shigella flexneri 2a str. 2457T lipoyl synthase NP_836354.1 686537 D 198215 CDS NP_836355.1 30062184 1077104 complement(687603..687806) 1 NC_004741.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase E 687806 tatE 1077104 tatE Shigella flexneri 2a str. 2457T twin arginine translocase E NP_836355.1 687603 R 198215 CDS NP_836356.1 30062185 1077105 complement(687935..688498) 1 NC_004741.1 residues 1 to 187 of 187 are 94.11 pct identical to residues 1 to 187 of 187 from Escherichia coli K-12 : B0626; amidase 688498 ybeM 1077105 ybeM Shigella flexneri 2a str. 2457T amidase NP_836356.1 687935 R 198215 CDS NP_836357.1 30062186 1077107 688816..689199 1 NC_004741.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 689199 ccrB 1077107 ccrB Shigella flexneri 2a str. 2457T camphor resistance protein CrcB NP_836357.1 688816 D 198215 CDS NP_836358.1 30062187 1078238 complement(689253..689462) 1 NC_004741.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 689462 cspE 1078238 cspE Shigella flexneri 2a str. 2457T cold shock protein CspE NP_836358.1 689253 R 198215 CDS NP_836359.1 30062188 1077108 complement(689637..690197) 1 NC_004741.1 catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 690197 pagP 1077108 pagP Shigella flexneri 2a str. 2457T palmitoyl transferase NP_836359.1 689637 R 198215 CDS NP_836360.1 30062189 1077109 690786..692171 1 NC_004741.1 responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 692171 dcuC 1077109 dcuC Shigella flexneri 2a str. 2457T C4-dicarboxylate transporter DcuC NP_836360.1 690786 D 198215 CDS NP_836361.1 30062190 1077113 complement(692891..693400) 1 NC_004741.1 residues 20 to 169 of 169 are 35.08 pct identical to residues 4 to 174 of 174 from GenPept : >gb|AAF01132.1|AF083977_53 (AF083977) c-repressor [Enterobacteria phage Mu]; repressor protein 693400 1077113 S0684 Shigella flexneri 2a str. 2457T repressor protein NP_836361.1 692891 R 198215 CDS NP_836362.1 30062191 1077114 693963..695417 1 NC_004741.1 residues 1 to 484 of 484 are 96.90 pct identical to residues 62 to 545 of 663 from GenPept : >gb|AAF01083.1|AF083977_2 (AF083977) A [Enterobacteria phage Mu]; phage transposase 695417 1077114 S0685 Shigella flexneri 2a str. 2457T phage transposase NP_836362.1 693963 D 198215 CDS NP_836363.1 30062192 1077115 695479..695781 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 695781 1077115 S0686 Shigella flexneri 2a str. 2457T IS600 orfA NP_836363.1 695479 D 198215 CDS NP_836364.1 30062193 1080944 695922..696635 1 NC_004741.1 residues 1 to 237 of 237 are 99.57 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72454.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 696635 1080944 S0687 Shigella flexneri 2a str. 2457T IS600 orfB NP_836364.1 695922 D 198215 CDS NP_836365.1 30062194 1080945 complement(696632..696877) 1 NC_004741.1 residues 1 to 50 of 81 are 68.62 pct identical to residues 1 to 51 of 122 from GenPept : >emb|CAD05577.1| (AL627272) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 696877 1080945 S0688 Shigella flexneri 2a str. 2457T hypothetical protein NP_836365.1 696632 R 198215 CDS NP_836366.1 30062195 1077116 complement(696919..697860) 1 NC_004741.1 residues 1 to 313 of 313 are 97.76 pct identical to residues 1 to 313 of 313 from GenPept : >emb|CAD05445.1| (AL627268) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein 697860 1077116 S0689 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836366.1 696919 R 198215 CDS NP_836367.1 30062196 1077117 complement(697872..697973) 1 NC_004741.1 residues 1 to 33 of 33 are 100.00 pct identical to residues 136 to 168 of 168 from GenPept : >emb|CAD05444.1| (AL627268) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 697973 1077117 S0690 Shigella flexneri 2a str. 2457T hypothetical protein NP_836367.1 697872 R 198215 CDS NP_836368.1 30062197 1077118 complement(698005..698361) 1 NC_004741.1 residues 1 to 116 of 118 are 100.00 pct identical to residues 1 to 116 of 168 from GenPept : >emb|CAD05444.1| (AL627268) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein 698361 1077118 S0691 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836368.1 698005 R 198215 CDS NP_836369.1 30062198 1077119 complement(698365..699585) 1 NC_004741.1 residues 1 to 406 of 406 are 89.90 pct identical to residues 1 to 406 of 406 from GenPept : >emb|CAD05443.1| (AL627268) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein 699585 1077119 S0692 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836369.1 698365 R 198215 CDS NP_836370.1 30062199 1077120 complement(699589..700047) 1 NC_004741.1 residues 2 to 141 of 152 are 86.42 pct identical to residues 29 to 168 of 176 from GenPept : >emb|CAD05581.1| (AL627272) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein 700047 1077120 S0693 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836370.1 699589 R 198215 CDS NP_836371.1 30062200 1077121 complement(700223..701689) 1 NC_004741.1 residues 1 to 488 of 488 are 96.72 pct identical to residues 1 to 488 of 488 from GenPept : >emb|CAD05582.1| (AL627272) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein 701689 1077121 S0694 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836371.1 700223 R 198215 CDS NP_836372.1 30062201 1077122 complement(701689..701922) 1 NC_004741.1 residues 1 to 77 of 77 are 81.81 pct identical to residues 391 to 467 of 467 from GenPept : >emb|CAD05583.1| (AL627272) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 701922 1077122 S0695 Shigella flexneri 2a str. 2457T hypothetical protein NP_836372.1 701689 R 198215 CDS NP_836373.1 30062202 1077123 complement(701910..702449) 1 NC_004741.1 residues 10 to 167 of 179 are 96.20 pct identical to residues 222 to 379 of 467 from GenPept : >emb|CAD05583.1| (AL627272) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein 702449 1077123 S0696 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836373.1 701910 R 198215 CDS NP_836374.2 161486529 1077124 complement(702434..703339) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 703339 1077124 S0697 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_836374.2 702434 R 198215 CDS NP_836375.2 161486528 1077125 complement(703297..703662) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 703662 1077125 S0698 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_836375.2 703297 R 198215 CDS NP_836376.1 30062205 1077126 complement(703738..704361) 1 NC_004741.1 residues 2 to 203 of 207 are 99.50 pct identical to residues 22 to 223 of 467 from GenPept : >emb|CAD05583.1| (AL627272) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein 704361 1077126 S0699 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836376.1 703738 R 198215 CDS NP_836377.1 30062206 1077129 complement(704372..705136) 1 NC_004741.1 residues 1 to 249 of 254 are 97.18 pct identical to residues 1 to 249 of 249 from GenPept : >emb|CAD05584.1| (AL627272) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein 705136 1077129 S0700 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836377.1 704372 R 198215 CDS NP_836378.1 30062207 1077128 complement(705206..705832) 1 NC_004741.1 residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB 705832 1077128 S0701 Shigella flexneri 2a str. 2457T IS911 orfB NP_836378.1 705206 R 198215 CDS NP_836379.1 30062208 1077127 complement(705829..706029) 1 NC_004741.1 partial; IS911 orfB 706029 1077127 S0702 Shigella flexneri 2a str. 2457T IS911 orfB NP_836379.1 705829 R 198215 CDS NP_836380.1 30062209 1077130 complement(706072..706374) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 706374 1077130 S0703 Shigella flexneri 2a str. 2457T IS911 orfA NP_836380.1 706072 R 198215 CDS NP_836381.1 30062210 1077131 706519..706692 1 NC_004741.1 residues 1 to 55 of 57 are 90.90 pct identical to residues 100 to 154 of 155 from GenPept : >gb|AAG55117.1|AE005256_8 (AE005256) endopeptidase Rz of prophage CP-933K [Escherichia coli O157:H7 EDL933]; partial; hypothetical protein 706692 1077131 S0704 Shigella flexneri 2a str. 2457T hypothetical protein NP_836381.1 706519 D 198215 CDS NP_836382.1 30062211 1077587 707502..707804 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 707804 1077587 S0705 Shigella flexneri 2a str. 2457T IS911 orfA NP_836382.1 707502 D 198215 CDS NP_836383.1 30062212 1077132 707847..708047 1 NC_004741.1 partial; IS911 orfB 708047 1077132 S0706 Shigella flexneri 2a str. 2457T IS911 orfB NP_836383.1 707847 D 198215 CDS NP_836384.1 30062213 1077083 708044..708202 1 NC_004741.1 residues 1 to 43 of 52 are 97.67 pct identical to residues 72 to 114 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB 708202 1077083 S0707 Shigella flexneri 2a str. 2457T IS911 orfB NP_836384.1 708044 D 198215 CDS NP_836385.1 30062214 1077133 708293..708667 1 NC_004741.1 residues 1 to 124 of 124 are 100.00 pct identical to residues 156 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB 708667 1077133 S0708 Shigella flexneri 2a str. 2457T IS911 orfB NP_836385.1 708293 D 198215 CDS NP_836386.1 30062215 1077134 708696..709118 1 NC_004741.1 residues 1 to 140 of 140 are 88.57 pct identical to residues 49 to 188 of 188 from GenPept : >gb|AAG56172.1|AE005347_4 (AE005347) unknown protein encoded within prophage CP-933O [Escherichia coli O157:H7 EDL933]; bacteriophage protein 709118 1077134 S0709 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836386.1 708696 D 198215 CDS NP_836387.1 30062216 1077139 710297..710389 1 NC_004741.1 residues 1 to 30 of 30 are 89.99 pct identical to residues 1 to 30 of 71 from GenPept : >gb|AAA32349.1| (M65239) S [Bacteriophage 21]; hypothetical protein 710389 ybcR 1077139 ybcR Shigella flexneri 2a str. 2457T hypothetical protein NP_836387.1 710297 D 198215 CDS NP_836388.1 30062217 1077140 complement(710430..711116) 1 NC_004741.1 residues 1 to 228 of 228 are 87.34 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 711116 1077140 S0715 Shigella flexneri 2a str. 2457T IS600 orfB NP_836388.1 710430 R 198215 CDS NP_836389.1 30062218 1077141 complement(711257..711559) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 711559 1077141 S0716 Shigella flexneri 2a str. 2457T IS600 orfA NP_836389.1 711257 R 198215 CDS NP_836390.1 30062219 1077142 711835..713694 1 NC_004741.1 residues 368 to 567 of 619 are 29.32 pct identical to residues 690 to 895 of 916 from GenPept : >gb|AAF10830.1|AE001973_3 (AE001973) SNF2/Rad54 helicase-related protein [Deinococcus radiodurans]; bacteriophage protein 713694 1077142 S0718 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836390.1 711835 D 198215 CDS NP_836391.1 30062220 1077143 complement(713669..714295) 1 NC_004741.1 residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB 714295 1077143 S0719 Shigella flexneri 2a str. 2457T IS911 orfB NP_836391.1 713669 R 198215 CDS NP_836392.1 30062221 1077144 complement(714292..714492) 1 NC_004741.1 partial; IS911 orfB 714492 1077144 S0720 Shigella flexneri 2a str. 2457T IS911 orfB NP_836392.1 714292 R 198215 CDS NP_836393.1 30062222 1078460 complement(714535..714837) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 714837 1078460 S0721 Shigella flexneri 2a str. 2457T IS911 orfA NP_836393.1 714535 R 198215 CDS NP_836394.1 30062223 1077145 714930..715808 1 NC_004741.1 residues 41 to 292 of 292 are 95.63 pct identical to residues 1 to 252 of 252 from GenPept : >emb|CAC83536.1| (AJ298298) replication protein DnaC [Bacteriophage P27]; replication protein DnaC 715808 1077145 S0722 Shigella flexneri 2a str. 2457T replication protein DnaC NP_836394.1 714930 D 198215 CDS NP_836395.1 30062224 1077146 715805..717196 1 NC_004741.1 residues 1 to 463 of 463 are 90.49 pct identical to residues 1 to 463 of 463 from GenPept : >emb|CAC83537.1| (AJ298298) helicase [Bacteriophage P27]; helicase 717196 1077146 S0723 Shigella flexneri 2a str. 2457T helicase NP_836395.1 715805 D 198215 CDS NP_836396.1 30062225 1077147 717193..717450 1 NC_004741.1 residues 6 to 85 of 85 are 93.75 pct identical to residues 1 to 80 of 80 from GenPept : >emb|CAC83538.1| (AJ298298) hypothetical protein [Bacteriophage P27]; bacteriophage protein 717450 1077147 S0724 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836396.1 717193 D 198215 CDS NP_836397.1 30062226 1077148 717545..717745 1 NC_004741.1 residues 1 to 66 of 66 are 63.63 pct identical to residues 1 to 64 of 64 from GenPept : >gb|AAD04654.1| (AF034975) nin orf-59 [Bacteriophage H-19B]; homologous to ninH gene; bacteriophage protein 717745 1077148 S0725 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836397.1 717545 D 198215 CDS NP_836398.1 30062227 1077149 717738..718118 1 NC_004741.1 residues 1 to 124 of 126 are 77.41 pct identical to residues 1 to 124 of 144 from GenPept : >gb|AAD04655.1| (AF034975) Q protein [Bacteriophage H-19B]; Q protein 718118 ybcQ 1077149 ybcQ Shigella flexneri 2a str. 2457T Q protein NP_836398.1 717738 D 198215 CDS NP_836399.1 30062228 1080348 718921..719136 1 NC_004741.1 residues 1 to 71 of 71 are 74.64 pct identical to residues 1 to 71 of 71 from GenPept : >gb|AAA32349.1| (M65239) S [Bacteriophage 21]; S protein 719136 1080348 S0731 Shigella flexneri 2a str. 2457T S protein NP_836399.1 718921 D 198215 CDS NP_836400.1 30062229 1077154 719140..719769 1 NC_004741.1 no significant similarities; hypothetical protein 719769 1077154 S0732 Shigella flexneri 2a str. 2457T hypothetical protein NP_836400.1 719140 D 198215 CDS NP_836401.1 30062230 1077155 719835..720368 1 NC_004741.1 residues 1 to 177 of 177 are 83.61 pct identical to residues 1 to 177 of 177 from GenPept : >gb|AAG55897.1|AE005323_13 (AE005323) endolysin of prophage CP-933N [Escherichia coli O157:H7 EDL933]; endolysin R of prophage CP-933V 720368 1077155 S0733 Shigella flexneri 2a str. 2457T endolysin R of prophage CP-933V NP_836401.1 719835 D 198215 CDS NP_836402.1 30062231 1077156 720365..720769 1 NC_004741.1 residues 1 to 134 of 134 are 96.26 pct identical to residues 1 to 134 of 155 from GenPept : >gb|AAK28885.1|AF335538_37 (AF335538) endopeptidase [Bacteriophage HK620]; endopeptidase 720769 1077156 S0734 Shigella flexneri 2a str. 2457T endopeptidase NP_836402.1 720365 D 198215 CDS NP_836403.1 30062232 1077157 720831..721133 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 721133 1077157 S0735 Shigella flexneri 2a str. 2457T IS600 orfA NP_836403.1 720831 D 198215 CDS NP_836404.1 30062233 1077159 721274..721987 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 721987 1077159 S0736 Shigella flexneri 2a str. 2457T IS600 orfB NP_836404.1 721274 D 198215 CDS NP_836405.1 30062234 1077160 722310..724220 1 NC_004741.1 residues 1 to 625 of 636 are 91.20 pct identical to residues 13 to 636 of 654 from GenPept : >gb|AAG56410.1|AE005368_16 (AE005368) DNA packaging protein of prophage CP-933R; terminase large subunit [Escherichia coli O157:H7 EDL933]; DNA packaging protein of prophage CP-933R; terminase large subunit 724220 1077160 S0737 Shigella flexneri 2a str. 2457T DNA packaging protein of prophage CP-933R; terminase large subunit NP_836405.1 722310 D 198215 CDS NP_836406.1 30062235 1077161 724221..724424 1 NC_004741.1 residues 1 to 67 of 67 are 79.41 pct identical to residues 1 to 68 of 68 from GenPept : >gb|AAA32341.1| (M81255) head completion protein gp3 [Bacteriophage 21]; head completion protein gp3 724424 1077161 S0738 Shigella flexneri 2a str. 2457T head completion protein gp3 NP_836406.1 724221 D 198215 CDS NP_836407.1 30062236 1077162 724421..725476 1 NC_004741.1 residues 1 to 331 of 351 are 94.25 pct identical to residues 1 to 331 of 530 from GenPept : >gb|AAA32342.1| (M81255) head-tail preconnector gp5 [Bacteriophage 21]; head-tail preconnector gp5 725476 1077162 S0739 Shigella flexneri 2a str. 2457T head-tail preconnector gp5 NP_836407.1 724421 D 198215 CDS NP_836408.1 30062237 1077702 725391..726014 1 NC_004741.1 residues 2 to 193 of 207 are 93.75 pct identical to residues 325 to 516 of 530 from GenPept : >gb|AAA32342.1| (M81255) head-tail preconnector gp5 [Bacteriophage 21]; head-tail preconnector gp5 726014 1077702 S0740 Shigella flexneri 2a str. 2457T head-tail preconnector gp5 NP_836408.1 725391 D 198215 CDS NP_836409.1 30062238 1077163 726004..727509 1 NC_004741.1 residues 1 to 501 of 501 are 88.62 pct identical to residues 1 to 501 of 501 from GenPept : >gb|AAA32343.1| (M81255) head-tail preconnector gp5 [Bacteriophage 21]; head-tail preconnector gp5 727509 1077163 S0741 Shigella flexneri 2a str. 2457T head-tail preconnector gp5 NP_836409.1 726004 D 198215 CDS NP_836410.1 30062239 1077164 727546..727893 1 NC_004741.1 residues 1 to 115 of 115 are 93.04 pct identical to residues 1 to 115 of 115 from GenPept : >gb|AAA32345.1| (M81255) capsid protein small subunit [Bacteriophage 21]; capsid protein small subunit 727893 1077164 S0742 Shigella flexneri 2a str. 2457T capsid protein small subunit NP_836410.1 727546 D 198215 CDS NP_836411.1 30062240 1077165 727951..728979 1 NC_004741.1 residues 1 to 342 of 342 are 90.35 pct identical to residues 1 to 342 of 342 from GenPept : >gb|AAA32346.1| (M81255) major capsid protein [Bacteriophage 21]; major capsid protein 728979 1077165 S0743 Shigella flexneri 2a str. 2457T major capsid protein NP_836411.1 727951 D 198215 CDS NP_836412.1 30062241 1077166 729031..729417 1 NC_004741.1 residues 3 to 128 of 128 are 37.40 pct identical to residues 2 to 132 of 132 from GenPept : >gb|AAA96541.1| (J02459) Fi (DNA packaging;117) [bacteriophage lambda]; DNA-packaging protein 729417 1077166 S0744 Shigella flexneri 2a str. 2457T DNA-packaging protein NP_836412.1 729031 D 198215 CDS NP_836413.1 30062242 1077167 729429..729806 1 NC_004741.1 residues 1 to 117 of 125 are 57.26 pct identical to residues 1 to 117 of 117 from GenPept : >gb|AAA96542.1| (J02459) Fii (head-tail joining;117) [bacteriophage lambda]; tail attachment protein 729806 1077167 S0745 Shigella flexneri 2a str. 2457T tail attachment protein NP_836413.1 729429 D 198215 CDS NP_836414.1 30062243 1077168 729793..730377 1 NC_004741.1 residues 1 to 194 of 194 are 84.53 pct identical to residues 1 to 192 of 192 from GenPept : >gb|AAG55126.1|AE005257_5 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail component of prophage CP-933K 730377 1077168 S0746 Shigella flexneri 2a str. 2457T tail component of prophage CP-933K NP_836414.1 729793 D 198215 CDS NP_836415.1 30062244 1077169 730374..730775 1 NC_004741.1 residues 1 to 133 of 133 are 96.99 pct identical to residues 1 to 133 of 133 from GenPept : >gb|AAG55127.1|AE005257_6 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail component of prophage CP-933K 730775 1077169 S0747 Shigella flexneri 2a str. 2457T tail component of prophage CP-933K NP_836415.1 730374 D 198215 CDS NP_836416.1 30062245 1077170 730786..731526 1 NC_004741.1 residues 1 to 245 of 246 are 82.85 pct identical to residues 3 to 247 of 249 from GenPept : >gb|AAG55128.1|AE005257_7 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail component of prophage CP-933K 731526 1077170 S0748 Shigella flexneri 2a str. 2457T tail component of prophage CP-933K NP_836416.1 730786 D 198215 CDS NP_836417.1 30062246 1077171 731585..731971 1 NC_004741.1 residues 1 to 128 of 128 are 92.18 pct identical to residues 5 to 132 of 132 from GenPept : >gb|AAG55129.1|AE005257_8 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail component of prophage CP-933K 731971 1077171 S0749 Shigella flexneri 2a str. 2457T tail component of prophage CP-933K NP_836417.1 731585 D 198215 CDS NP_836418.1 30062247 1077172 732034..732309 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 15 to 105 of 105 from GenPept : >gb|AAG55130.1|AE005257_9 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail component of prophage CP-933K 732309 1077172 S0750 Shigella flexneri 2a str. 2457T tail component of prophage CP-933K NP_836418.1 732034 D 198215 CDS NP_836419.1 30062248 1077173 732281..735322 1 NC_004741.1 residues 1 to 1013 of 1013 are 78.64 pct identical to residues 1 to 1021 of 1021 from GenPept : >dbj|BAB34260.1| (AP002553) tail length tape measure protein precursor [Escherichia coli O157:H7]; tail length tape measure protein precursor 735322 1077173 S0751 Shigella flexneri 2a str. 2457T tail length tape measure protein precursor NP_836419.1 732281 D 198215 CDS NP_836420.1 30062249 1080995 735322..735651 1 NC_004741.1 residues 1 to 108 of 109 are 97.22 pct identical to residues 1 to 108 of 109 from GenPept : >dbj|BAB34261.1| (AP002553) minor tail protein [Escherichia coli O157:H7]; minor tail protein 735651 1080995 S0752 Shigella flexneri 2a str. 2457T minor tail protein NP_836420.1 735322 D 198215 CDS NP_836421.1 30062250 1077174 735651..736349 1 NC_004741.1 residues 1 to 232 of 232 are 90.51 pct identical to residues 1 to 232 of 232 from GenPept : >dbj|BAB35068.1| (AP002555) minor tail protein [Escherichia coli O157:H7]; minor tail protein 736349 1077174 S0753 Shigella flexneri 2a str. 2457T minor tail protein NP_836421.1 735651 D 198215 CDS NP_836422.1 30062251 1080350 736498..737097 1 NC_004741.1 residues 1 to 199 of 199 are 96.98 pct identical to residues 26 to 224 of 224 from GenPept : >gb|AAG55134.1|AE005257_13 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail assembly protein 737097 1080350 S0754 Shigella flexneri 2a str. 2457T tail assembly protein NP_836422.1 736498 D 198215 CDS NP_836423.1 30062252 1077175 737094..737636 1 NC_004741.1 residues 1 to 180 of 180 are 85.71 pct identical to residues 34 to 215 of 215 from GenPept : >gb|AAG55135.1|AE005257_14 (AE005257) tail component of prophage CP-933K [Escherichia coli O157:H7 EDL933]; tail component 737636 1077175 S0755 Shigella flexneri 2a str. 2457T tail component NP_836423.1 737094 D 198215 CDS NP_836424.1 30062253 1077176 737697..741176 1 NC_004741.1 residues 1 to 1159 of 1159 are 85.13 pct identical to residues 1 to 1132 of 1132 from GenPept : >dbj|BAB35071.1| (AP002555) host specificity protein [Escherichia coli O157:H7]; host specificity protein 741176 1077176 S0756 Shigella flexneri 2a str. 2457T host specificity protein NP_836424.1 737697 D 198215 CDS NP_836425.1 30062254 1077177 741244..741843 1 NC_004741.1 residues 1 to 199 of 199 are 93.46 pct identical to residues 1 to 199 of 199 from GenPept : >dbj|BAB35072.1| (AP002555) membrane protein precursor [Escherichia coli O157:H7]; membrane protein precursor 741843 1077177 S0757 Shigella flexneri 2a str. 2457T membrane protein precursor NP_836425.1 741244 D 198215 CDS NP_836426.1 30062255 1077178 741907..742968 1 NC_004741.1 residues 1 to 291 of 353 are 39.11 pct identical to residues 1 to 294 of 490 from GenPept : >emb|CAC83574.1| (AJ298298) tail fiber protein [Bacteriophage P27]; tail component encoded by cryptic prophage CP-933M 742968 1077178 S0758 Shigella flexneri 2a str. 2457T tail component encoded by cryptic prophage CP-933M NP_836426.1 741907 D 198215 CDS NP_836427.1 30062256 1077179 743269..743892 1 NC_004741.1 residues 21 to 207 of 207 are 68.44 pct identical to residues 2 to 188 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; tail component of prophage CP-933K 743892 1077179 S0759 Shigella flexneri 2a str. 2457T tail component of prophage CP-933K NP_836427.1 743269 D 198215 CDS NP_836428.1 30062257 1077181 745944..746123 1 NC_004741.1 no significant similarities; hypothetical protein 746123 1077181 S0763 Shigella flexneri 2a str. 2457T hypothetical protein NP_836428.1 745944 D 198215 CDS NP_836429.1 30062258 1077182 complement(746417..746893) 1 NC_004741.1 YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein 746893 ybhB 1077182 ybhB Shigella flexneri 2a str. 2457T kinase inhibitor protein NP_836429.1 746417 R 198215 CDS NP_836430.1 30062259 1077235 complement(746952..748241) 1 NC_004741.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 748241 bioA 1077235 bioA Shigella flexneri 2a str. 2457T adenosylmethionine-8-amino-7-oxononanoate aminotransferase NP_836430.1 746952 R 198215 CDS NP_836431.1 30062260 1077183 748328..749368 1 NC_004741.1 residues 1 to 346 of 346 are 99.42 pct identical to residues 1 to 346 of 346 from Escherichia coli K-12 : B0775; biotin synthase 749368 bioB 1077183 bioB Shigella flexneri 2a str. 2457T biotin synthase NP_836431.1 748328 D 198215 CDS NP_836432.1 30062261 1077184 749365..750519 1 NC_004741.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 750519 bioF 1077184 bioF Shigella flexneri 2a str. 2457T 8-amino-7-oxononanoate synthase NP_836432.1 749365 D 198215 CDS NP_836433.1 30062262 1077185 750506..751261 1 NC_004741.1 methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 751261 bioC 1077185 bioC Shigella flexneri 2a str. 2457T biotin biosynthesis protein BioC NP_836433.1 750506 D 198215 CDS NP_836434.1 30062263 1077187 751254..751931 1 NC_004741.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 751931 bioD 1077187 bioD Shigella flexneri 2a str. 2457T dithiobiotin synthetase NP_836434.1 751254 D 198215 CDS NP_836435.1 30062264 1077188 752510..754531 1 NC_004741.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 754531 uvrB 1077188 uvrB Shigella flexneri 2a str. 2457T excinuclease ABC subunit B NP_836435.1 752510 D 198215 CDS NP_836436.1 30062265 1080351 complement(754723..755631) 1 NC_004741.1 residues 1 to 302 of 302 are 91.39 pct identical to residues 1 to 302 of 302 from Escherichia coli K-12 : B0780; structural protein 755631 ybhK 1080351 ybhK Shigella flexneri 2a str. 2457T structural protein NP_836436.1 754723 R 198215 CDS NP_836437.1 30062266 1077189 756028..757017 1 NC_004741.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 757017 moaA 1077189 moaA Shigella flexneri 2a str. 2457T molybdenum cofactor biosynthesis protein A NP_836437.1 756028 D 198215 CDS NP_836438.1 30062267 1077190 757039..757551 1 NC_004741.1 residues 1 to 170 of 170 are 99.41 pct identical to residues 1 to 170 of 170 from Escherichia coli K-12 : B0782; molybdopterin biosynthesis protein B 757551 moaB 1077190 moaB Shigella flexneri 2a str. 2457T molybdopterin biosynthesis protein B NP_836438.1 757039 D 198215 CDS NP_836439.1 30062268 1077192 757554..758039 1 NC_004741.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein C 758039 moaC 1077192 moaC Shigella flexneri 2a str. 2457T molybdenum cofactor biosynthesis protein C NP_836439.1 757554 D 198215 CDS NP_836440.1 30062269 1077193 758032..758277 1 NC_004741.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 758277 moaD 1077193 moaD Shigella flexneri 2a str. 2457T molybdopterin synthase small subunit NP_836440.1 758032 D 198215 CDS NP_836441.1 30062270 1077194 758279..758731 1 NC_004741.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase large subunit 758731 moaE 1077194 moaE Shigella flexneri 2a str. 2457T molybdopterin synthase large subunit NP_836441.1 758279 D 198215 CDS NP_836442.1 30062271 1077195 758868..759572 1 NC_004741.1 residues 1 to 234 of 234 are 93.16 pct identical to residues 1 to 234 of 234 from Escherichia coli K-12 : B0786; hypothetical protein 759572 ybhL 1077195 ybhL Shigella flexneri 2a str. 2457T hypothetical protein NP_836442.1 758868 D 198215 CDS NP_836443.1 30062272 1077196 759777..760490 1 NC_004741.1 residues 1 to 237 of 237 are 80.16 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B0787; hypothetical protein 760490 ybhM 1077196 ybhM Shigella flexneri 2a str. 2457T hypothetical protein NP_836443.1 759777 D 198215 CDS NP_836444.1 30062273 1077197 complement(760526..761482) 1 NC_004741.1 residues 1 to 318 of 318 are 78.30 pct identical to residues 1 to 318 of 318 from Escherichia coli K-12 : B0788; hypothetical protein 761482 ybhN 1077197 ybhN Shigella flexneri 2a str. 2457T hypothetical protein NP_836444.1 760526 R 198215 CDS NP_836445.1 30062274 1077198 complement(761482..762723) 1 NC_004741.1 residues 1 to 413 of 413 are 91.76 pct identical to residues 1 to 413 of 413 from Escherichia coli K-12 : B0789; cardiolipin synthase 2 762723 ybhO 1077198 ybhO Shigella flexneri 2a str. 2457T cardiolipin synthase 2 NP_836445.1 761482 R 198215 CDS NP_836446.1 30062275 1077199 complement(762720..763481) 1 NC_004741.1 residues 1 to 253 of 253 are 100.00 pct identical to residues 1 to 253 of 253 from Escherichia coli K-12 : B0790; hypothetical protein 763481 ybhP 1077199 ybhP Shigella flexneri 2a str. 2457T hypothetical protein NP_836446.1 762720 R 198215 CDS NP_836447.1 30062276 1077201 763614..764024 1 NC_004741.1 residues 1 to 136 of 136 are 83.08 pct identical to residues 1 to 136 of 136 from Escherichia coli K-12 : B0791; hypothetical protein 764024 ybhQ 1077201 ybhQ Shigella flexneri 2a str. 2457T hypothetical protein NP_836447.1 763614 D 198215 CDS NP_836448.1 30062277 1077202 complement(763986..765092) 1 NC_004741.1 residues 1 to 368 of 368 are 96.73 pct identical to residues 1 to 368 of 368 from Escherichia coli K-12 : B0792; hypothetical protein 765092 ybhR 1077202 ybhR Shigella flexneri 2a str. 2457T hypothetical protein NP_836448.1 763986 R 198215 CDS NP_836449.1 30062278 1077191 complement(765103..766236) 1 NC_004741.1 residues 1 to 377 of 377 are 92.83 pct identical to residues 1 to 377 of 377 from Escherichia coli K-12 : B0793; hypothetical protein 766236 ybhS 1077191 ybhS Shigella flexneri 2a str. 2457T hypothetical protein NP_836449.1 765103 R 198215 CDS NP_836450.1 30062279 1077203 complement(766229..767980) 1 NC_004741.1 residues 1 to 583 of 583 are 99.82 pct identical to residues 1 to 583 of 583 from Escherichia coli K-12 : B0794; ATP-binding component of a transport system 767980 ybhF 1077203 ybhF Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_836450.1 766229 R 198215 CDS NP_836451.1 30062280 1077204 complement(767958..768956) 1 NC_004741.1 residues 1 to 332 of 332 are 82.53 pct identical to residues 1 to 332 of 332 from Escherichia coli K-12 : B0795; hypothetical protein 768956 1077204 S0786 Shigella flexneri 2a str. 2457T hypothetical protein NP_836451.1 767958 R 198215 CDS NP_836452.1 30062281 1077205 complement(768956..769639) 1 NC_004741.1 residues 1 to 227 of 227 are 88.98 pct identical to residues 1 to 227 of 227 from Escherichia coli K-12 : B0796; DNA-binding transcriptional regulator 769639 ybiH 1077205 ybiH Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator NP_836452.1 768956 R 198215 CDS NP_836453.1 30062282 1077206 769856..771076 1 NC_004741.1 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 771076 rhlE 1077206 rhlE Shigella flexneri 2a str. 2457T ATP-dependent RNA helicase RhlE NP_836453.1 769856 D 198215 CDS NP_836454.1 30062283 1077207 complement(771250..771732) 1 NC_004741.1 residues 1 to 160 of 160 are 96.87 pct identical to residues 1 to 160 of 160 from Escherichia coli K-12 : B0798; hypothetical protein 771732 ybiA 1077207 ybiA Shigella flexneri 2a str. 2457T hypothetical protein NP_836454.1 771250 R 198215 CDS NP_836455.1 30062284 1077208 771852..774002 1 NC_004741.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 774002 dinG 1077208 dinG Shigella flexneri 2a str. 2457T ATP-dependent DNA helicase DinG NP_836455.1 771852 D 198215 CDS NP_836456.1 30062285 1077209 774030..774992 1 NC_004741.1 residues 1 to 320 of 320 are 98.43 pct identical to residues 1 to 320 of 320 from Escherichia coli K-12 : B0800; glycosyl transferase family protein 774992 ybiB 1077209 ybiB Shigella flexneri 2a str. 2457T glycosyl transferase family protein NP_836456.1 774030 D 198215 CDS NP_836457.1 30062286 1077210 775133..776218 1 NC_004741.1 residues 1 to 361 of 361 are 98.89 pct identical to residues 1 to 361 of 361 from Escherichia coli K-12 : B0801; hypothetical protein 776218 ybiC 1077210 ybiC Shigella flexneri 2a str. 2457T hypothetical protein NP_836457.1 775133 D 198215 CDS NP_836458.1 30062287 1077211 complement(776447..776707) 1 NC_004741.1 residues 1 to 86 of 86 are 84.88 pct identical to residues 1 to 86 of 86 from Escherichia coli K-12 : B0802; hypothetical protein 776707 ybiJ 1077211 ybiJ Shigella flexneri 2a str. 2457T hypothetical protein NP_836458.1 776447 R 198215 CDS NP_836459.1 30062288 1077212 complement(776972..777238) 1 NC_004741.1 residues 1 to 88 of 88 are 96.59 pct identical to residues 1 to 88 of 88 from Escherichia coli K-12 : B0803; hypothetical protein 777238 ybiI 1077212 ybiI Shigella flexneri 2a str. 2457T hypothetical protein NP_836459.1 776972 R 198215 CDS NP_836460.2 161486527 1077213 complement(777312..777989) 1 NC_004741.1 residues 1 to 237 of 237 are 93.24 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B0804; hydroxylase 777989 ybiX 1077213 ybiX Shigella flexneri 2a str. 2457T hydroxylase NP_836460.2 777312 R 198215 CDS NP_836461.1 30062290 1077214 780105..781433 1 NC_004741.1 residues 1 to 442 of 442 are 99.54 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 781433 1077214 S0797 Shigella flexneri 2a str. 2457T IS4 orf NP_836461.1 780105 D 198215 CDS NP_836462.1 30062291 1077215 complement(782016..782420) 1 NC_004741.1 residues 1 to 134 of 134 are 98.50 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B0806; hypothetical protein 782420 ybiM 1077215 ybiM Shigella flexneri 2a str. 2457T hypothetical protein NP_836462.1 782016 R 198215 CDS NP_836463.1 30062292 1077216 782471..783478 1 NC_004741.1 residues 2 to 336 of 336 are 90.74 pct identical to residues 1 to 335 of 335 from Escherichia coli K-12 : B0807; SAM-dependent methyltransferase 783478 ybiN 1077216 ybiN Shigella flexneri 2a str. 2457T SAM-dependent methyltransferase NP_836463.1 782471 D 198215 CDS NP_836464.1 30062293 1077218 complement(785960..786682) 1 NC_004741.1 similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 786682 glnQ 1077218 glnQ Shigella flexneri 2a str. 2457T glutamine ABC transporter ATP-binding protein NP_836464.1 785960 R 198215 CDS NP_836465.1 30062294 1077219 complement(786679..787338) 1 NC_004741.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 787338 glnP 1077219 glnP Shigella flexneri 2a str. 2457T glutamine ABC transporter permease NP_836465.1 786679 R 198215 CDS NP_836466.1 30062295 1077220 complement(787477..788223) 1 NC_004741.1 similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein 788223 glnH 1077220 glnH Shigella flexneri 2a str. 2457T glutamine ABC transporter periplasmic protein NP_836466.1 787477 R 198215 CDS NP_836467.1 30062296 1077186 complement(788627..789130) 1 NC_004741.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 789130 dps 1077186 dps Shigella flexneri 2a str. 2457T DNA starvation/stationary phase protection protein Dps NP_836467.1 788627 R 198215 CDS NP_836468.1 30062297 1077200 complement(789429..790316) 1 NC_004741.1 residues 1 to 295 of 295 are 91.52 pct identical to residues 1 to 295 of 295 from Escherichia coli K-12 : B0813; threonine and homoserine efflux system 790316 ybiF 1077200 ybiF Shigella flexneri 2a str. 2457T threonine and homoserine efflux system NP_836468.1 789429 R 198215 CDS NP_836469.1 30062298 1077222 790669..791184 1 NC_004741.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 791184 ompX 1077222 ompX Shigella flexneri 2a str. 2457T outer membrane protein X NP_836469.1 790669 D 198215 CDS NP_836470.1 30062299 1077223 complement(791232..792815) 1 NC_004741.1 residues 1 to 527 of 527 are 97.72 pct identical to residues 1 to 527 of 527 from Escherichia coli K-12 : B0815; enzyme 792815 ybiP 1077223 ybiP Shigella flexneri 2a str. 2457T enzyme NP_836470.1 791232 R 198215 CDS NP_836471.1 30062300 1077225 793401..793868 1 NC_004741.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 793868 1077225 S0810 Shigella flexneri 2a str. 2457T manganese transport regulator MntR NP_836471.1 793401 D 198215 CDS NP_836472.1 30062301 1077227 793865..794983 1 NC_004741.1 residues 1 to 371 of 372 are 87.60 pct identical to residues 1 to 371 of 372 from Escherichia coli K-12 : B0818; hypothetical protein 794983 ybiR 1077227 ybiR Shigella flexneri 2a str. 2457T hypothetical protein NP_836472.1 793865 D 198215 CDS NP_836473.1 30062302 1077228 complement(795042..795962) 1 NC_004741.1 residues 1 to 306 of 306 are 99.67 pct identical to residues 1 to 306 of 306 from Escherichia coli K-12 : B0819; hypothetical protein 795962 ybiS 1077228 ybiS Shigella flexneri 2a str. 2457T hypothetical protein NP_836473.1 795042 R 198215 CDS NP_836474.1 30062303 1077243 796181..797773 1 NC_004741.1 residues 1 to 530 of 530 are 99.81 pct identical to residues 1 to 530 of 530 from Escherichia coli K-12 : B0820; ATP-binding component of a transport system 797773 ybiT 1077243 ybiT Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_836474.1 796181 D 198215 CDS NP_836475.1 30062304 1077229 complement(798014..799279) 1 NC_004741.1 residues 1 to 421 of 421 are 99.04 pct identical to residues 1 to 421 of 421 from Escherichia coli K-12 : B0821; hypothetical protein 799279 ybiU 1077229 ybiU Shigella flexneri 2a str. 2457T hypothetical protein NP_836475.1 798014 R 198215 CDS NP_836476.1 30062305 1077230 complement(799431..800246) 1 NC_004741.1 residues 1 to 271 of 271 are 99.63 pct identical to residues 1 to 271 of 271 from Escherichia coli K-12 : B0822; hypothetical protein 800246 1077230 S0815 Shigella flexneri 2a str. 2457T hypothetical protein NP_836476.1 799431 R 198215 CDS NP_836477.1 30062306 1077231 complement(800392..802824) 1 NC_004741.1 residues 1 to 810 of 810 are 93.20 pct identical to residues 1 to 810 of 810 from Escherichia coli K-12 : B0823; formate acetyltransferase 802824 ybiW 1077231 ybiW Shigella flexneri 2a str. 2457T formate acetyltransferase NP_836477.1 800392 R 198215 CDS NP_836478.1 30062307 1077232 complement(802830..803756) 1 NC_004741.1 residues 1 to 308 of 308 are 94.48 pct identical to residues 1 to 308 of 308 from Escherichia coli K-12 : B0824; pyruvate formate-lyase 2 activating enzyme 803756 ybiY 1077232 ybiY Shigella flexneri 2a str. 2457T pyruvate formate-lyase 2 activating enzyme NP_836478.1 802830 R 198215 CDS NP_836479.2 161486526 1077233 803860..804522 1 NC_004741.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 804522 mipB 1077233 mipB Shigella flexneri 2a str. 2457T fructose-6-phosphate aldolase NP_836479.2 803860 D 198215 CDS NP_836480.1 30062309 1077234 complement(804701..805450) 1 NC_004741.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 805450 moeB 1077234 moeB Shigella flexneri 2a str. 2457T molybdopterin biosynthesis protein MoeB NP_836480.1 804701 R 198215 CDS NP_836481.1 30062310 1077236 complement(805450..806685) 1 NC_004741.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 806685 moeA 1077236 moeA Shigella flexneri 2a str. 2457T molybdopterin biosynthesis protein MoeA NP_836481.1 805450 R 198215 CDS NP_836482.1 30062311 1077237 806889..807854 1 NC_004741.1 residues 1 to 321 of 321 are 95.95 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B0828; L-asparaginase 807854 ybiK 1077237 ybiK Shigella flexneri 2a str. 2457T L-asparaginase NP_836482.1 806889 D 198215 CDS NP_836483.1 30062312 1077238 807874..809712 1 NC_004741.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 809712 1077238 S0822 Shigella flexneri 2a str. 2457T glutathione transporter ATP-binding protein NP_836483.1 807874 D 198215 CDS NP_836484.1 30062313 1077239 809732..811270 1 NC_004741.1 residues 1 to 512 of 512 are 99.41 pct identical to residues 1 to 512 of 512 from Escherichia coli K-12 : B0830; transporter 811270 1077239 S0823 Shigella flexneri 2a str. 2457T transporter NP_836484.1 809732 D 198215 CDS NP_836485.1 30062314 1077240 811288..812208 1 NC_004741.1 residues 1 to 306 of 306 are 87.58 pct identical to residues 1 to 306 of 306 from Escherichia coli K-12 : B0831; transport system permease 812208 1077240 S0824 Shigella flexneri 2a str. 2457T transport system permease NP_836485.1 811288 D 198215 CDS NP_836486.1 30062315 1077241 812211..813122 1 NC_004741.1 residues 1 to 303 of 303 are 95.04 pct identical to residues 1 to 303 of 303 from Escherichia coli K-12 : B0832; transport system permease 813122 1077241 S0825 Shigella flexneri 2a str. 2457T transport system permease NP_836486.1 812211 D 198215 CDS NP_836487.1 30062316 1077244 815650..816978 1 NC_004741.1 residues 1 to 442 of 442 are 99.32 pct identical to residues 1 to 442 of 442 from Escherichia coli K-12 : B0834; hypothetical protein 816978 1077244 S0827 Shigella flexneri 2a str. 2457T hypothetical protein NP_836487.1 815650 D 198215 CDS NP_836488.1 30062317 1077246 complement(817025..818350) 1 NC_004741.1 residues 1 to 441 of 441 are 96.82 pct identical to residues 1 to 441 of 441 from Escherichia coli K-12 : B0835; hypothetical protein 818350 yliG 1077246 yliG Shigella flexneri 2a str. 2457T hypothetical protein NP_836488.1 817025 R 198215 CDS NP_836489.1 30062318 1077005 818563..818946 1 NC_004741.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 818946 bssR 1077005 bssR Shigella flexneri 2a str. 2457T biofilm formation regulatory protein BssR NP_836489.1 818563 D 198215 CDS NP_836490.1 30062319 1077248 complement(820168..820800) 1 NC_004741.1 residues 1 to 210 of 210 are 89.99 pct identical to residues 1 to 210 of 210 from Escherichia coli K-12 : B0838; transferase 820800 yliJ 1077248 yliJ Shigella flexneri 2a str. 2457T transferase NP_836490.1 820168 R 198215 CDS NP_836491.1 30062320 1077250 822062..822364 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 822364 1077250 S0833 Shigella flexneri 2a str. 2457T IS600 orfA NP_836491.1 822062 D 198215 CDS NP_836492.1 30062321 1077251 822505..823218 1 NC_004741.1 residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 823218 1077251 S0834 Shigella flexneri 2a str. 2457T IS600 orfB NP_836492.1 822505 D 198215 CDS NP_836493.1 30062322 1077252 complement(823555..824313) 1 NC_004741.1 residues 1 to 252 of 252 are 94.84 pct identical to residues 1 to 252 of 252 from Escherichia coli K-12 : B0840; DNA-binding transcriptional repressor DeoR 824313 deoR 1077252 deoR Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor DeoR NP_836493.1 823555 R 198215 CDS NP_836494.1 30062323 1077253 complement(824371..824967) 1 NC_004741.1 residues 1 to 198 of 198 are 91.41 pct identical to residues 1 to 198 of 198 from Escherichia coli K-12 : B0841; undecaprenyl pyrophosphate phosphatase 824967 ybjG 1077253 ybjG Shigella flexneri 2a str. 2457T undecaprenyl pyrophosphate phosphatase NP_836494.1 824371 R 198215 CDS NP_836495.1 30062324 1077254 825252..826478 1 NC_004741.1 residues 1 to 408 of 408 are 95.12 pct identical to residues 1 to 410 of 410 from Escherichia coli K-12 : B0842; proton motive force efflux pump; chloramphenicol resistance pump Cmr 826478 cmr 1077254 cmr Shigella flexneri 2a str. 2457T chloramphenicol resistance pump Cmr NP_836495.1 825252 D 198215 CDS NP_836496.1 30062325 1077255 complement(826519..826803) 1 NC_004741.1 residues 1 to 94 of 94 are 57.44 pct identical to residues 1 to 94 of 94 from Escherichia coli K-12 : B0843; hypothetical protein 826803 ybjH 1077255 ybjH Shigella flexneri 2a str. 2457T hypothetical protein NP_836496.1 826519 R 198215 CDS NP_836497.1 30062326 1077257 complement(826889..827677) 1 NC_004741.1 residues 1 to 262 of 262 are 98.85 pct identical to residues 1 to 262 of 262 from Escherichia coli K-12 : B0844; hypothetical protein 827677 1077257 S0840 Shigella flexneri 2a str. 2457T hypothetical protein NP_836497.1 826889 R 198215 CDS NP_836498.1 30062327 1077258 complement(827704..828912) 1 NC_004741.1 residues 1 to 402 of 402 are 85.82 pct identical to residues 1 to 402 of 402 from Escherichia coli K-12 : B0845; DEOR-type transcriptional regulator 828912 1077258 S0841 Shigella flexneri 2a str. 2457T DEOR-type transcriptional regulator NP_836498.1 827704 R 198215 CDS NP_836499.1 30062328 1077888 828996..829532 1 NC_004741.1 residues 1 to 178 of 178 are 99.43 pct identical to residues 1 to 178 of 178 from Escherichia coli K-12 : B0846; DEOR-type transcriptional regulator 829532 1077888 S0842 Shigella flexneri 2a str. 2457T DEOR-type transcriptional regulator NP_836499.1 828996 D 198215 CDS NP_836500.1 30062329 1077259 complement(829707..831392) 1 NC_004741.1 residues 1 to 561 of 561 are 93.76 pct identical to residues 1 to 561 of 561 from Escherichia coli K-12 : B0847; hypothetical protein 831392 1077259 S0843 Shigella flexneri 2a str. 2457T hypothetical protein NP_836500.1 829707 R 198215 CDS NP_836501.1 30062330 1077626 831662..832039 1 NC_004741.1 residues 1 to 125 of 125 are 100.00 pct identical to residues 1 to 125 of 125 from Escherichia coli K-12 : B0848; hypothetical protein 832039 ybjM 1077626 ybjM Shigella flexneri 2a str. 2457T hypothetical protein NP_836501.1 831662 D 198215 CDS NP_836502.1 30062331 1077260 complement(832069..832326) 1 NC_004741.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 832326 grxA 1077260 grxA Shigella flexneri 2a str. 2457T glutaredoxin NP_836502.1 832069 R 198215 CDS NP_836503.1 30062332 1077261 832486..832773 1 NC_004741.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 832773 ybjC 1077261 ybjC Shigella flexneri 2a str. 2457T hypothetical protein NP_836503.1 832486 D 198215 CDS NP_836504.1 30062333 1077262 832757..833479 1 NC_004741.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 833479 mdaA 1077262 mdaA Shigella flexneri 2a str. 2457T nitroreductase A NP_836504.1 832757 D 198215 CDS NP_836505.1 30062334 1077263 833540..834442 1 NC_004741.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 834442 rimK 1077263 rimK Shigella flexneri 2a str. 2457T ribosomal protein S6 modification protein NP_836505.1 833540 D 198215 CDS NP_836506.1 30062335 1077264 834530..835006 1 NC_004741.1 residues 1 to 158 of 158 are 100.00 pct identical to residues 1 to 158 of 158 from Escherichia coli K-12 : B0853; sensory transduction regulator 835006 ybjN 1077264 ybjN Shigella flexneri 2a str. 2457T sensory transduction regulator NP_836506.1 834530 D 198215 CDS NP_836507.1 30062336 1077265 835358..836470 1 NC_004741.1 residues 1 to 370 of 370 are 99.72 pct identical to residues 1 to 370 of 370 from Escherichia coli K-12 : B0854; putrescine transporter subunit: periplasmic-binding component of ABC superfamily 836470 potF 1077265 potF Shigella flexneri 2a str. 2457T putrescine transporter subunit: periplasmic-binding component of ABC superfamily NP_836507.1 835358 D 198215 CDS NP_836508.2 161486525 1077266 836565..837698 1 NC_004741.1 part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding subunit 837698 potG 1077266 potG Shigella flexneri 2a str. 2457T putrescine transporter ATP-binding subunit NP_836508.2 836565 D 198215 CDS NP_836509.1 30062338 1077267 837708..838661 1 NC_004741.1 residues 1 to 317 of 317 are 89.90 pct identical to residues 1 to 317 of 317 from Escherichia coli K-12 : B0856; putrescine transporter subunit: membrane component of ABC superfamily 838661 potH 1077267 potH Shigella flexneri 2a str. 2457T putrescine transporter subunit: membrane component of ABC superfamily NP_836509.1 837708 D 198215 CDS NP_836510.1 30062339 1077268 838658..839503 1 NC_004741.1 residues 1 to 281 of 281 are 86.47 pct identical to residues 1 to 281 of 281 from Escherichia coli K-12 : B0857; putrescine transporter subunit: membrane component of ABC superfamily 839503 potI 1077268 potI Shigella flexneri 2a str. 2457T putrescine transporter subunit: membrane component of ABC superfamily NP_836510.1 838658 D 198215 CDS NP_836511.1 30062340 1077269 839563..840051 1 NC_004741.1 residues 1 to 162 of 162 are 91.35 pct identical to residues 1 to 162 of 162 from Escherichia coli K-12 : B0858; hypothetical protein 840051 ybjO 1077269 ybjO Shigella flexneri 2a str. 2457T hypothetical protein NP_836511.1 839563 D 198215 CDS NP_836512.1 30062341 1080932 840092..841219 1 NC_004741.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 841219 rumB 1080932 rumB Shigella flexneri 2a str. 2457T 23S rRNA methyluridine methyltransferase NP_836512.1 840092 D 198215 CDS NP_836513.1 30062342 1077270 complement(841394..842125) 1 NC_004741.1 residues 1 to 243 of 243 are 92.18 pct identical to residues 1 to 243 of 243 from Escherichia coli K-12 : B0860; arginine 3rd transport system periplasmic binding protein 842125 artJ 1077270 artJ Shigella flexneri 2a str. 2457T arginine 3rd transport system periplasmic binding protein NP_836513.1 841394 R 198215 CDS NP_836514.1 30062343 1077271 complement(842417..843085) 1 NC_004741.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 843085 artM 1077271 artM Shigella flexneri 2a str. 2457T arginine transporter permease subunit ArtM NP_836514.1 842417 R 198215 CDS NP_836515.1 30062344 1077272 complement(843085..843801) 1 NC_004741.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 843801 artQ 1077272 artQ Shigella flexneri 2a str. 2457T arginine transporter permease subunit ArtQ NP_836515.1 843085 R 198215 CDS NP_836516.1 30062345 1077273 complement(843808..844539) 1 NC_004741.1 residues 1 to 243 of 243 are 99.17 pct identical to residues 1 to 243 of 243 from Escherichia coli K-12 : B0863; arginine 3rd transport system periplasmic binding protein 844539 artI 1077273 artI Shigella flexneri 2a str. 2457T arginine 3rd transport system periplasmic binding protein NP_836516.1 843808 R 198215 CDS NP_836517.1 30062346 1077274 complement(844557..845285) 1 NC_004741.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 845285 artP 1077274 artP Shigella flexneri 2a str. 2457T arginine transporter ATP-binding subunit NP_836517.1 844557 R 198215 CDS NP_836518.1 30062347 1077275 complement(845503..846018) 1 NC_004741.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; lipoprotein 846018 ybjP 1077275 ybjP Shigella flexneri 2a str. 2457T lipoprotein NP_836518.1 845503 R 198215 CDS NP_836519.1 30062348 1077276 complement(846032..846214) 1 NC_004741.1 residues 1 to 61 of 61 are 100.00 pct identical to residues 1 to 61 of 61 from NP_286635.1, Z1096 gene product Escherichia coli O157:H7 EDL933; hypothetical protein 846214 1077276 S4813 Shigella flexneri 2a str. 2457T hypothetical protein NP_836519.1 846032 R 198215 CDS NP_836520.1 30062349 1077277 846667..848436 1 NC_004741.1 residues 1 to 402 of 589 are 94.52 pct identical to residues 12 to 412 of 413 from NP_286636.1 Z1097 gene product Escherichia coli O157:H7 EDL933, NP_308976.1 hypothetical protein Escherichia coli O157:H7; E90747 hypothetical protein ECs0949 Escherichia coli (strain O157:H7, substrain RIMD 0509952), B85598 hypothetical protein Z1097; hypothetical protein 848436 1077277 S4814 Shigella flexneri 2a str. 2457T hypothetical protein NP_836520.1 846667 D 198215 CDS NP_836521.1 30062350 1077278 848646..848969 1 NC_004741.1 residues 1 to 107 of 107 are 99.06 pct identical to residues 1 to 107 of 107 from Escherichia coli K-12 : B0866; hypothetical protein 848969 1077278 S0862 Shigella flexneri 2a str. 2457T hypothetical protein NP_836521.1 848646 D 198215 CDS NP_836522.1 30062351 1077279 848966..849796 1 NC_004741.1 residues 1 to 276 of 276 are 94.92 pct identical to residues 1 to 276 of 276 from Escherichia coli K-12 : B0867; regulator 849796 1077279 S0863 Shigella flexneri 2a str. 2457T regulator NP_836522.1 848966 D 198215 CDS NP_836523.1 30062352 1077280 complement(849793..850842) 1 NC_004741.1 residues 1 to 349 of 349 are 98.56 pct identical to residues 1 to 349 of 349 from Escherichia coli K-12 : B0868; nucleotide di-P-sugar epimerase or dehydratase 850842 1077280 S0864 Shigella flexneri 2a str. 2457T nucleotide di-P-sugar epimerase or dehydratase NP_836523.1 849793 R 198215 CDS NP_836524.1 30062353 1077281 complement(850905..852335) 1 NC_004741.1 residues 1 to 476 of 476 are 96.00 pct identical to residues 11 to 486 of 486 from Escherichia coli K-12 : B0869; dTDP-glucose enzyme 852335 ybjT 1077281 ybjT Shigella flexneri 2a str. 2457T dTDP-glucose enzyme NP_836524.1 850905 R 198215 CDS NP_836525.1 30062354 1077282 complement(852346..853347) 1 NC_004741.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase 853347 ybjU 1077282 ybjU Shigella flexneri 2a str. 2457T L-threonine aldolase NP_836525.1 852346 R 198215 CDS NP_836526.1 30062355 1077283 complement(853384..855102) 1 NC_004741.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 855102 poxB 1077283 poxB Shigella flexneri 2a str. 2457T pyruvate dehydrogenase NP_836526.1 853384 R 198215 CDS NP_836527.1 30062356 1077284 complement(855235..856203) 1 NC_004741.1 residues 1 to 322 of 322 are 94.40 pct identical to residues 1 to 322 of 322 from Escherichia coli K-12 : B0872; HCP oxidoreductase, NADH-dependent 856203 1077284 S0868 Shigella flexneri 2a str. 2457T HCP oxidoreductase, NADH-dependent NP_836527.1 855235 R 198215 CDS NP_836528.2 161486524 1077285 complement(856215..857867) 1 NC_004741.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 857867 ybjW 1077285 ybjW Shigella flexneri 2a str. 2457T hydroxylamine reductase NP_836528.2 856215 R 198215 CDS NP_836529.1 30062358 1077286 complement(858011..858958) 1 NC_004741.1 residues 1 to 315 of 315 are 87.61 pct identical to residues 1 to 315 of 315 from Escherichia coli K-12 : B0874; surface protein 858958 ybjE 1077286 ybjE Shigella flexneri 2a str. 2457T surface protein NP_836529.1 858011 R 198215 CDS NP_836530.2 161486523 1077287 complement(859034..859939) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 859939 1077287 S0871 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_836530.2 859034 R 198215 CDS NP_836531.2 161486522 1077288 complement(859897..860262) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 860262 1077288 S0872 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_836531.2 859897 R 198215 CDS NP_836532.1 30062361 1077289 complement(860703..861398) 1 NC_004741.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 861398 aqpZ 1077289 aqpZ Shigella flexneri 2a str. 2457T aquaporin Z NP_836532.1 860703 R 198215 CDS NP_836533.1 30062362 1077290 complement(861450..861953) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 861953 1077290 S0874 Shigella flexneri 2a str. 2457T IS1 orfB NP_836533.1 861450 R 198215 CDS NP_836534.1 30062363 1077291 complement(861872..862147) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 862147 1077291 S0875 Shigella flexneri 2a str. 2457T IS1 orfA NP_836534.1 861872 R 198215 CDS NP_836535.1 30062364 1077292 862599..864257 1 NC_004741.1 residues 1 to 552 of 552 are 97.10 pct identical to residues 1 to 552 of 552 from Escherichia coli K-12 : B0876; hypothetical protein 864257 ybjD 1077292 ybjD Shigella flexneri 2a str. 2457T hypothetical protein NP_836535.1 862599 D 198215 CDS NP_836536.1 30062365 1080446 complement(864254..865246) 1 NC_004741.1 residues 1 to 330 of 330 are 95.75 pct identical to residues 1 to 330 of 330 from Escherichia coli K-12 : B0877; enzyme 865246 ybjX 1080446 ybjX Shigella flexneri 2a str. 2457T enzyme NP_836536.1 864254 R 198215 CDS NP_836537.1 30062366 1077293 865361..866476 1 NC_004741.1 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 866476 1077293 S0878 Shigella flexneri 2a str. 2457T macrolide transporter subunit MacA NP_836537.1 865361 D 198215 CDS NP_836538.1 30062367 1077294 866473..868419 1 NC_004741.1 with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 868419 ybjZ 1077294 ybjZ Shigella flexneri 2a str. 2457T macrolide transporter ATP-binding /permease NP_836538.1 866473 D 198215 CDS NP_836539.1 30062368 1077295 complement(868492..868716) 1 NC_004741.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 868716 cspD 1077295 cspD Shigella flexneri 2a str. 2457T stationary phase/starvation inducible regulatory protein CspD NP_836539.1 868492 R 198215 CDS NP_836540.1 30062369 1077296 869039..869359 1 NC_004741.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 869359 clpS 1077296 clpS Shigella flexneri 2a str. 2457T ATP-dependent Clp protease adaptor protein ClpS NP_836540.1 869039 D 198215 CDS NP_836541.1 30062370 1077297 869390..871666 1 NC_004741.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 871666 clpA 1077297 clpA Shigella flexneri 2a str. 2457T ATP-dependent Clp protease ATP-binding subunit NP_836541.1 869390 D 198215 CDS NP_836542.1 30062371 1077299 complement(872410..872628) 1 NC_004741.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 872628 infA 1077299 infA Shigella flexneri 2a str. 2457T translation initiation factor IF-1 NP_836542.1 872410 R 198215 CDS NP_836543.1 30062372 1077300 complement(872913..873617) 1 NC_004741.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 873617 aat 1077300 aat Shigella flexneri 2a str. 2457T leucyl/phenylalanyl-tRNA--protein transferase NP_836543.1 872913 R 198215 CDS NP_836544.1 30062373 1080456 complement(873659..875380) 1 NC_004741.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 875380 cydC 1080456 cydC Shigella flexneri 2a str. 2457T cysteine/glutathione ABC transporter membrane/ATP-binding component NP_836544.1 873659 R 198215 CDS NP_836545.1 30062374 1077301 complement(875381..877147) 1 NC_004741.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 877147 cydD 1077301 cydD Shigella flexneri 2a str. 2457T cysteine/glutathione ABC transporter membrane/ATP-binding component NP_836545.1 875381 R 198215 CDS NP_836546.1 30062375 1077302 complement(877270..878235) 1 NC_004741.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 878235 trxB 1077302 trxB Shigella flexneri 2a str. 2457T thioredoxin reductase NP_836546.1 877270 R 198215 CDS NP_836547.1 30062376 1077303 878779..879273 1 NC_004741.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 879273 lrp 1077303 lrp Shigella flexneri 2a str. 2457T leucine-responsive transcriptional regulator NP_836547.1 878779 D 198215 CDS NP_836548.1 30062377 1077304 879408..883436 1 NC_004741.1 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 883436 ftsK 1077304 ftsK Shigella flexneri 2a str. 2457T DNA translocase FtsK NP_836548.1 879408 D 198215 CDS NP_836549.1 30062378 1077306 883588..884202 1 NC_004741.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 884202 lolA 1077306 lolA Shigella flexneri 2a str. 2457T outer-membrane lipoprotein carrier protein NP_836549.1 883588 D 198215 CDS NP_836550.1 30062379 1077307 884213..885556 1 NC_004741.1 residues 1 to 447 of 447 are 99.55 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 : B0892; recombination factor protein RarA 885556 ycaJ 1077307 ycaJ Shigella flexneri 2a str. 2457T recombination factor protein RarA NP_836550.1 884213 D 198215 CDS NP_836551.1 30062380 1077308 885647..886939 1 NC_004741.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 886939 serS 1077308 serS Shigella flexneri 2a str. 2457T seryl-tRNA synthetase NP_836551.1 885647 D 198215 CDS NP_836552.1 30062381 1076457 887266..889623 1 NC_004741.1 residues 1 to 785 of 785 are 98.47 pct identical to residues 1 to 785 of 785 from Escherichia coli K-12 : B0894; anaerobic dimethyl sulfoxide reductase subunit A 889623 dmsA 1076457 dmsA Shigella flexneri 2a str. 2457T anaerobic dimethyl sulfoxide reductase subunit A NP_836552.1 887266 D 198215 CDS NP_836553.1 30062382 1077309 889634..890251 1 NC_004741.1 residues 1 to 205 of 205 are 100.00 pct identical to residues 1 to 205 of 205 from Escherichia coli K-12 : B0895; anaerobic dimethyl sulfoxide reductase subunit B 890251 dmsB 1077309 dmsB Shigella flexneri 2a str. 2457T anaerobic dimethyl sulfoxide reductase subunit B NP_836553.1 889634 D 198215 CDS NP_836554.1 30062383 1077310 890253..891044 1 NC_004741.1 residues 1 to 263 of 263 are 85.01 pct identical to residues 1 to 287 of 287 from Escherichia coli K-12 : B0896; anaerobic dimethyl sulfoxide reductase subunit C 891044 dmsC 1077310 dmsC Shigella flexneri 2a str. 2457T anaerobic dimethyl sulfoxide reductase subunit C NP_836554.1 890253 D 198215 CDS NP_836555.1 30062384 1077311 complement(891080..891706) 1 NC_004741.1 residues 1 to 208 of 208 are 98.55 pct identical to residues 1 to 208 of 208 from Escherichia coli K-12 : B0897; hypothetical protein 891706 ycaC 1077311 ycaC Shigella flexneri 2a str. 2457T hypothetical protein NP_836555.1 891080 R 198215 CDS NP_836556.1 30062385 1076630 892021..893169 1 NC_004741.1 residues 1 to 382 of 382 are 90.31 pct identical to residues 1 to 382 of 382 from Escherichia coli K-12 : B0898; MFS family transporter protein 893169 ycaD 1076630 ycaD Shigella flexneri 2a str. 2457T MFS family transporter protein NP_836556.1 892021 D 198215 CDS NP_836557.1 30062386 1077312 893482..894156 1 NC_004741.1 residues 1 to 224 of 224 are 99.10 pct identical to residues 1 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 894156 1077312 S0899 Shigella flexneri 2a str. 2457T ISSfl3 orfA NP_836557.1 893482 D 198215 CDS NP_836558.1 30062387 1077313 894153..894503 1 NC_004741.1 residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAK18528.1|AF348706_217 (AF348706) IS orf [Shigella flexneri]; partial; ISSfl3 orfB 894503 1077313 S0900 Shigella flexneri 2a str. 2457T ISSfl3 orfB NP_836558.1 894153 D 198215 CDS NP_836559.1 30062388 1077314 894500..896101 1 NC_004741.1 residues 1 to 533 of 533 are 97.37 pct identical to residues 1 to 533 of 533 from GenPept : >gb|AAL72376.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfC,D 896101 1077314 S0901 Shigella flexneri 2a str. 2457T ISSfl3 orfC,D NP_836559.1 894500 D 198215 CDS NP_836560.1 30062389 1077315 complement(897507..897809) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 897809 1077315 S0905 Shigella flexneri 2a str. 2457T IS911 orfA NP_836560.1 897507 R 198215 CDS NP_836561.1 30062390 1077372 complement(897790..897996) 1 NC_004741.1 residues 1 to 38 of 68 are 100.00 pct identical to residues 41 to 78 of 172 from GenPept : >gb|AAG56426.1|AE005369_15 (AE005369) unknown protein encoded within prophage CP-933R [Escherichia coli O157:H7 EDL933]; bacteriophage protein 897996 1077372 S0906 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836561.1 897790 R 198215 CDS NP_836562.1 30062391 1077316 complement(897993..898283) 1 NC_004741.1 residues 1 to 96 of 96 are 96.87 pct identical to residues 1 to 96 of 96 from GenPept : >emb|CAD05594.1| (AL627272) bacteriophage protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein 898283 1077316 S0907 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836562.1 897993 R 198215 CDS NP_836563.1 30062392 1077317 complement(898283..898414) 1 NC_004741.1 residues 1 to 43 of 43 are 97.67 pct identical to residues 157 to 199 of 199 from GenPept : >emb|CAD05595.1| (AL627272) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 898414 1077317 S0908 Shigella flexneri 2a str. 2457T hypothetical protein NP_836563.1 898283 R 198215 CDS NP_836564.1 30062393 1077318 898581..898883 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 898883 1077318 S0909 Shigella flexneri 2a str. 2457T IS600 orfA NP_836564.1 898581 D 198215 CDS NP_836565.1 30062394 1077319 899024..899737 1 NC_004741.1 residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 899737 1077319 S0910 Shigella flexneri 2a str. 2457T IS600 orfB NP_836565.1 899024 D 198215 CDS NP_836566.1 30062395 1077320 complement(899777..900148) 1 NC_004741.1 residues 1 to 123 of 123 are 97.56 pct identical to residues 1 to 123 of 199 from GenPept : >gb|AAG56427.1|AE005369_16 (AE005369) unknown protein encoded within prophage CP-933R [Escherichia coli O157:H7 EDL933]; hypothetical protein 900148 1077320 S0911 Shigella flexneri 2a str. 2457T hypothetical protein NP_836566.1 899777 R 198215 CDS NP_836567.1 30062396 1077321 complement(900724..900822) 1 NC_004741.1 residues 1 to 32 of 32 are 93.75 pct identical to residues 39 to 70 of 70 from GenPept : >emb|CAD05598.1| (AL627272) host cell-killing modulation protein [Salmonella enterica subsp. enterica serovar Typhi]; host cell-killing modulation protein 900822 1077321 S0912 Shigella flexneri 2a str. 2457T host cell-killing modulation protein NP_836567.1 900724 R 198215 CDS NP_836568.1 30062397 1077322 complement(901106..901672) 1 NC_004741.1 residues 1 to 183 of 188 are 81.42 pct identical to residues 33 to 215 of 236 from GenPept : >gb|AAF85072.1|AE004039_7 (AE004039) conserved hypothetical protein [Xylella fastidiosa 9a5c]; hypothetical protein 901672 1077322 S0913 Shigella flexneri 2a str. 2457T hypothetical protein NP_836568.1 901106 R 198215 CDS NP_836569.1 30062398 1077323 complement(902354..902776) 1 NC_004741.1 residues 1 to 140 of 140 are 69.99 pct identical to residues 1 to 140 of 140 from GenPept : >gb|AAG56435.1|AE005370_8 (AE005370) unknown protein encoded within prophage CP-933R [Escherichia coli O157:H7 EDL933]; bacteriophage protein 902776 1077323 S0914 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836569.1 902354 R 198215 CDS NP_836570.1 30062399 1077325 complement(903683..904321) 1 NC_004741.1 residues 1 to 201 of 212 are 97.01 pct identical to residues 1 to 201 of 262 from GenPept : >emb|CAD05607.1| (AL627272) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein 904321 1077325 S0917 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836570.1 903683 R 198215 CDS NP_836571.1 30062400 1077326 complement(904399..904821) 1 NC_004741.1 residues 1 to 127 of 140 are 88.97 pct identical to residues 1 to 127 of 140 from GenPept : >emb|CAD05608.1| (AL627272) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; bacteriophage protein 904821 1077326 S0918 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836571.1 904399 R 198215 CDS NP_836572.1 30062401 1077327 complement(904805..905032) 1 NC_004741.1 residues 1 to 73 of 75 are 90.41 pct identical to residues 1 to 73 of 75 from GenPept : >gb|AAG56121.1|AE005343_11 (AE005343) regulator of cell division encoded by prophage CP-933O [Escherichia coli O157:H7 EDL933]; DNA-binding transcriptional regulator DicC 905032 1077327 S0919 Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator DicC NP_836572.1 904805 R 198215 CDS NP_836573.1 30062402 1080797 905720..905875 1 NC_004741.1 residues 1 to 51 of 51 are 92.15 pct identical to residues 1 to 51 of 51 from GenPept : >emb|CAD05611.1| (AL627272) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 905875 1080797 S0920 Shigella flexneri 2a str. 2457T hypothetical protein NP_836573.1 905720 D 198215 CDS NP_836574.1 30062403 1080953 905877..906080 1 NC_004741.1 residues 1 to 67 of 67 are 97.01 pct identical to residues 1 to 67 of 67 from GenPept : >emb|CAD05612.1| (AL627272) conserved hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 906080 1080953 S0921 Shigella flexneri 2a str. 2457T hypothetical protein NP_836574.1 905877 D 198215 CDS NP_836575.2 161486521 1077328 complement(906322..907227) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 907227 1077328 S0922 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_836575.2 906322 R 198215 CDS NP_836576.2 161486520 1080078 complement(907185..907550) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 907550 1080078 S0923 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_836576.2 907185 R 198215 CDS NP_836577.1 30062406 1077329 908098..908637 1 NC_004741.1 residues 1 to 179 of 179 are 85.47 pct identical to residues 1 to 179 of 179 from GenPept : >emb|CAA80648.1| (Z23101) Sequence similarity to P4 ORF199 suggests ORF179 expression [Shigella flexneri]; bacteriophage protein 908637 1077329 S0924 Shigella flexneri 2a str. 2457T bacteriophage protein NP_836577.1 908098 D 198215 CDS NP_836578.1 30062407 1077330 908598..908945 1 NC_004741.1 no significant similarities; hypothetical protein 908945 1077330 S0925 Shigella flexneri 2a str. 2457T hypothetical protein NP_836578.1 908598 D 198215 CDS NP_836579.1 30062408 1077331 909459..909761 1 NC_004741.1 residues 1 to 100 of 100 are 99.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 909761 1077331 S0927 Shigella flexneri 2a str. 2457T IS600 orfA NP_836579.1 909459 D 198215 CDS NP_836580.1 30062409 1077332 909902..910615 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 910615 1077332 S0928 Shigella flexneri 2a str. 2457T IS600 orfB NP_836580.1 909902 D 198215 CDS NP_836581.1 30062410 1077333 complement(910640..911284) 1 NC_004741.1 residues 1 to 182 of 214 are 59.89 pct identical to residues 1 to 178 of 866 from GenPept : >gb|AAG56447.1|AE005371_3 (AE005371) exodeoxyribonuclease VIII of prophage CP-933R [Escherichia coli O157:H7 EDL933]; exodeoxyribonuclease VIII of prophage CP-933R 911284 1077333 S0929 Shigella flexneri 2a str. 2457T exodeoxyribonuclease VIII of prophage CP-933R NP_836581.1 910640 R 198215 CDS NP_836582.1 30062411 1077334 complement(911628..912068) 1 NC_004741.1 residues 1 to 146 of 146 are 100.00 pct identical to residues 1 to 146 of 146 from GenPept : >gb|AAL72524.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS600 orfB 912068 1077334 S0930 Shigella flexneri 2a str. 2457T IS600 orfB NP_836582.1 911628 R 198215 CDS NP_836583.1 30062412 1077335 complement(912483..912785) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 912785 1077335 S0931 Shigella flexneri 2a str. 2457T IS600 orfA NP_836583.1 912483 R 198215 CDS NP_836584.1 30062413 1077336 912851..913468 1 NC_004741.1 residues 19 to 205 of 205 are 71.12 pct identical to residues 2 to 188 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein 913468 1077336 S0932 Shigella flexneri 2a str. 2457T hypothetical protein NP_836584.1 912851 D 198215 CDS NP_836585.1 30062414 1077585 complement(913648..915474) 1 NC_004741.1 residues 1 to 608 of 608 are 63.71 pct identical to residues 1 to 565 of 565 from NRprotein_Feb03 : >ref|NP_085238.1| invasion plasmid antigen [Shigella flexneri] emb|CAC05787.1| IpaH7.8, member of the IpaH family, secreted by the Mxi-Spa secretion machinery, function unknown [Shigella flexneri]; invasion plasmid antigen 915474 ipaH_2 1077585 ipaH_2 Shigella flexneri 2a str. 2457T invasion plasmid antigen NP_836585.1 913648 R 198215 CDS NP_836586.1 30062415 1079910 916356..917351 1 NC_004741.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 917351 ybhE 1079910 ybhE Shigella flexneri 2a str. 2457T 6-phosphogluconolactonase NP_836586.1 916356 D 198215 CDS NP_836587.1 30062416 1077338 918634..919581 1 NC_004741.1 residues 1 to 315 of 315 are 99.68 pct identical to residues 36 to 350 of 350 from Escherichia coli K-12 : B0769; hypothetical protein 919581 ybhH 1077338 ybhH Shigella flexneri 2a str. 2457T hypothetical protein NP_836587.1 918634 D 198215 CDS NP_836588.1 30062417 1077339 919720..921090 1 NC_004741.1 residues 1 to 456 of 456 are 97.36 pct identical to residues 22 to 477 of 477 from Escherichia coli K-12 : B0770; membrane pump protein 921090 ybhI 1077339 ybhI Shigella flexneri 2a str. 2457T membrane pump protein NP_836588.1 919720 D 198215 CDS NP_836589.1 30062418 1077341 921273..923453 1 NC_004741.1 residues 1 to 726 of 726 are 96.41 pct identical to residues 9 to 761 of 761 from Escherichia coli K-12 : B0771; enzyme 923453 ybhJ 1077341 ybhJ Shigella flexneri 2a str. 2457T enzyme NP_836589.1 921273 D 198215 CDS NP_836590.1 30062419 1077342 complement(923594..924877) 1 NC_004741.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; pectinesterase 924877 ybhC 1077342 ybhC Shigella flexneri 2a str. 2457T pectinesterase NP_836590.1 923594 R 198215 CDS NP_836591.1 30062420 1077343 complement(925012..925782) 1 NC_004741.1 residues 1 to 256 of 256 are 100.00 pct identical to residues 32 to 287 of 287 from GenPept : >gb|AAG55102.1|AE005255_3 (AE005255) integrase encoded by prophage CP-933K; [Escherichia coli O157:H7 EDL933]; integrase encoded by prophage CP-933K; partial 925782 1077343 S0941 Shigella flexneri 2a str. 2457T integrase encoded by prophage CP-933K; partial NP_836591.1 925012 R 198215 CDS NP_836592.1 30062421 1077344 complement(925994..926707) 1 NC_004741.1 residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 926707 1077344 S0942 Shigella flexneri 2a str. 2457T IS600 orfB NP_836592.1 925994 R 198215 CDS NP_836593.1 30062422 1077345 complement(926848..927150) 1 NC_004741.1 residues 1 to 100 of 100 are 99.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 927150 1077345 S0943 Shigella flexneri 2a str. 2457T IS600 orfA NP_836593.1 926848 R 198215 CDS NP_836594.1 30062423 1077346 927343..927771 1 NC_004741.1 residues 1 to 101 of 142 are 78.21 pct identical to residues 1 to 101 of 165 from GenPept : >gb|AAG55116.1|AE005256_7 (AE005256) lysozyme protein R of prophage CP-933K [Escherichia coli O157:H7 EDL933]; lysozyme protein R of prophage CP-933K 927771 1077346 S0944 Shigella flexneri 2a str. 2457T lysozyme protein R of prophage CP-933K NP_836594.1 927343 D 198215 CDS NP_836595.1 30062424 1077347 927896..928393 1 NC_004741.1 residues 1 to 165 of 165 are 98.18 pct identical to residues 60 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 928393 1077347 S0945 Shigella flexneri 2a str. 2457T ISSfl3 orfA NP_836595.1 927896 D 198215 CDS NP_836596.1 30062425 1077348 928390..928740 1 NC_004741.1 residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAK18528.1|AF348706_217 (AF348706) IS orf [Shigella flexneri]; ISSfl3 orfB 928740 1077348 S0946 Shigella flexneri 2a str. 2457T ISSfl3 orfB NP_836596.1 928390 D 198215 CDS NP_836597.1 30062426 1077349 928737..929279 1 NC_004741.1 residues 1 to 165 of 180 are 92.12 pct identical to residues 1 to 165 of 533 from GenPept : >gb|AAL72472.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfC 929279 1077349 S0947 Shigella flexneri 2a str. 2457T ISSfl3 orfC NP_836597.1 928737 D 198215 CDS NP_836598.1 30062427 1077350 929285..929611 1 NC_004741.1 residues 1 to 108 of 108 are 71.29 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAF09023.1| (AF139596) unknown [Shigella flexneri]; IS629 orfA 929611 1077350 S0948 Shigella flexneri 2a str. 2457T IS629 orfA NP_836598.1 929285 D 198215 CDS NP_836599.1 30062428 1077351 929611..930498 1 NC_004741.1 residues 1 to 295 of 295 are 98.64 pct identical to residues 2 to 296 of 296 from GenPept : >gb|AAL67398.1|AF447814_66 (AF447814) transposase [Escherichia coli]; IS629 orfB 930498 1077351 S0949 Shigella flexneri 2a str. 2457T IS629 orfB NP_836599.1 929611 D 198215 CDS NP_836600.1 30062429 1077352 930482..930670 1 NC_004741.1 residues 21 to 62 of 62 are 100.00 pct identical to residues 492 to 533 of 533 from GenPept : >gb|AAL72472.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; hypothetical protein 930670 1077352 S0950 Shigella flexneri 2a str. 2457T hypothetical protein NP_836600.1 930482 D 198215 CDS NP_836601.1 30062430 1077355 931204..931479 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 931479 1077355 S0952 Shigella flexneri 2a str. 2457T IS1 orfA NP_836601.1 931204 D 198215 CDS NP_836602.1 30062431 1077356 931398..931901 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 931901 1077356 S0953 Shigella flexneri 2a str. 2457T IS1 orfB NP_836602.1 931398 D 198215 CDS NP_836603.1 30062432 1077359 933145..933447 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 933447 1077359 S0956 Shigella flexneri 2a str. 2457T IS600 orfA NP_836603.1 933145 D 198215 CDS NP_836604.1 30062433 1077360 933588..934301 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 934301 1077360 S0957 Shigella flexneri 2a str. 2457T IS600 orfB NP_836604.1 933588 D 198215 CDS NP_836605.1 30062434 1077361 complement(934544..935047) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 935047 1077361 S0958 Shigella flexneri 2a str. 2457T IS1 orfB NP_836605.1 934544 R 198215 CDS NP_836606.1 30062435 1077362 complement(935162..935875) 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 935875 1077362 S0959 Shigella flexneri 2a str. 2457T IS600 orfB NP_836606.1 935162 R 198215 CDS NP_836607.1 30062436 1077364 complement(936016..936318) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 936318 1077364 S0960 Shigella flexneri 2a str. 2457T IS600 orfA NP_836607.1 936016 R 198215 CDS NP_836608.1 30062437 1077365 complement(936727..937467) 1 NC_004741.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 937467 pflA 1077365 pflA Shigella flexneri 2a str. 2457T pyruvate formate lyase-activating enzyme 1 NP_836608.1 936727 R 198215 CDS NP_836609.1 30062438 1077366 complement(937659..939941) 1 NC_004741.1 residues 1 to 760 of 760 are 96.31 pct identical to residues 1 to 760 of 760 from Escherichia coli K-12 : B0903; formate acetyltransferase 1 939941 pflB 1077366 pflB Shigella flexneri 2a str. 2457T formate acetyltransferase 1 NP_836609.1 937659 R 198215 CDS NP_836610.1 30062439 1077367 complement(939996..940853) 1 NC_004741.1 residues 1 to 285 of 285 are 95.08 pct identical to residues 1 to 285 of 285 from Escherichia coli K-12 : B0904; formate transporter 940853 focA 1077367 focA Shigella flexneri 2a str. 2457T formate transporter NP_836610.1 939996 R 198215 CDS NP_836611.1 30062440 1077368 complement(941259..943019) 1 NC_004741.1 residues 1 to 586 of 586 are 96.75 pct identical to residues 4 to 589 of 589 from Escherichia coli K-12 : B0905; hypothetical protein 943019 ycaO 1077368 ycaO Shigella flexneri 2a str. 2457T hypothetical protein NP_836611.1 941259 R 198215 CDS NP_836612.1 30062441 1077371 943974..945062 1 NC_004741.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 945062 serC 1077371 serC Shigella flexneri 2a str. 2457T phosphoserine aminotransferase NP_836612.1 943974 D 198215 CDS NP_836613.1 30062442 1077373 945133..946416 1 NC_004741.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 946416 aroA 1077373 aroA Shigella flexneri 2a str. 2457T 3-phosphoshikimate 1-carboxyvinyltransferase NP_836613.1 945133 D 198215 CDS NP_836614.1 30062443 1077374 946560..947888 1 NC_004741.1 residues 1 to 442 of 442 are 99.54 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 947888 yi41 1077374 yi41 Shigella flexneri 2a str. 2457T IS4 orf NP_836614.1 946560 D 198215 CDS NP_836615.1 30062444 1077376 948024..948788 1 NC_004741.1 residues 1 to 254 of 254 are 93.70 pct identical to residues 9 to 262 of 262 from Escherichia coli K-12 : B0909; heat shock protein 948788 ycaL 1077376 ycaL Shigella flexneri 2a str. 2457T heat shock protein NP_836615.1 948024 D 198215 CDS NP_836616.1 30062445 1077363 948961..949644 1 NC_004741.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 949644 cmk 1077363 cmk Shigella flexneri 2a str. 2457T cytidylate kinase NP_836616.1 948961 D 198215 CDS NP_836617.1 30062446 1077377 949755..951428 1 NC_004741.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 951428 rpsA 1077377 rpsA Shigella flexneri 2a str. 2457T 30S ribosomal protein S1 NP_836617.1 949755 D 198215 CDS NP_836618.1 30062447 1077378 951588..951872 1 NC_004741.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 951872 ihfB 1077378 ihfB Shigella flexneri 2a str. 2457T integration host factor subunit beta NP_836618.1 951588 D 198215 CDS NP_836619.1 30062448 1077381 954375..956123 1 NC_004741.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 956123 msbA 1077381 msbA Shigella flexneri 2a str. 2457T lipid transporter ATP-binding/permease NP_836619.1 954375 D 198215 CDS NP_836620.1 30062449 1077382 956120..957106 1 NC_004741.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 957106 lpxK 1077382 lpxK Shigella flexneri 2a str. 2457T tetraacyldisaccharide 4'-kinase NP_836620.1 956120 D 198215 CDS NP_836621.1 30062450 1077383 957143..958375 1 NC_004741.1 residues 1 to 410 of 410 are 95.12 pct identical to residues 1 to 410 of 410 from Escherichia coli K-12 : B0916; hypothetical protein 958375 ycaQ 1077383 ycaQ Shigella flexneri 2a str. 2457T hypothetical protein NP_836621.1 957143 D 198215 CDS NP_836622.1 30062451 1077384 958427..958609 1 NC_004741.1 residues 1 to 60 of 60 are 100.00 pct identical to residues 1 to 60 of 60 from Escherichia coli K-12 : B0917; hypothetical protein 958609 ycaR 1077384 ycaR Shigella flexneri 2a str. 2457T hypothetical protein NP_836622.1 958427 D 198215 CDS NP_836623.1 30062452 1077385 958606..959352 1 NC_004741.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 959352 kdsB 1077385 kdsB Shigella flexneri 2a str. 2457T 3-deoxy-manno-octulosonate cytidylyltransferase NP_836623.1 958606 D 198215 CDS NP_836624.1 30062453 1077386 959506..960399 1 NC_004741.1 residues 1 to 297 of 297 are 100.00 pct identical to residues 1 to 297 of 297 from Escherichia coli K-12 : B0919; hypothetical protein 960399 1077386 S0979 Shigella flexneri 2a str. 2457T hypothetical protein NP_836624.1 959506 D 198215 CDS NP_836625.1 30062454 1080993 complement(960376..961155) 1 NC_004741.1 residues 1 to 259 of 259 are 89.18 pct identical to residues 1 to 259 of 259 from Escherichia coli K-12 : B0920; hypothetical protein 961155 ycbC 1080993 ycbC Shigella flexneri 2a str. 2457T hypothetical protein NP_836625.1 960376 R 198215 CDS NP_836626.1 30062455 1077387 961291..962076 1 NC_004741.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 962076 smtA 1077387 smtA Shigella flexneri 2a str. 2457T metallothionein SmtA NP_836626.1 961291 D 198215 CDS NP_836627.1 30062456 1077389 962073..963395 1 NC_004741.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 963395 mukF 1077389 mukF Shigella flexneri 2a str. 2457T condesin subunit F NP_836627.1 962073 D 198215 CDS NP_836628.1 30062457 1077390 963403..964080 1 NC_004741.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 964080 mukE 1077390 mukE Shigella flexneri 2a str. 2457T condesin subunit E NP_836628.1 963403 D 198215 CDS NP_836629.1 30062458 1077391 964080..968540 1 NC_004741.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 968540 mukB 1077391 mukB Shigella flexneri 2a str. 2457T cell division protein MukB NP_836629.1 964080 D 198215 CDS NP_836630.1 30062459 1077393 968703..970031 1 NC_004741.1 residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 970031 1077393 S0985 Shigella flexneri 2a str. 2457T IS4 orf NP_836630.1 968703 D 198215 CDS NP_836631.1 30062460 1077394 970239..972086 1 NC_004741.1 residues 1 to 615 of 615 are 96.58 pct identical to residues 1 to 615 of 615 from Escherichia coli K-12 : B0925; hypothetical protein 972086 ycbB 1077394 ycbB Shigella flexneri 2a str. 2457T hypothetical protein NP_836631.1 970239 D 198215 CDS NP_836632.1 30062461 1077395 972267..972815 1 NC_004741.1 residues 1 to 182 of 182 are 93.40 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 : B0926; hypothetical protein 972815 ycbK 1077395 ycbK Shigella flexneri 2a str. 2457T hypothetical protein NP_836632.1 972267 D 198215 CDS NP_836633.1 30062462 1077396 972842..973489 1 NC_004741.1 residues 1 to 215 of 215 are 99.53 pct identical to residues 1 to 215 of 215 from Escherichia coli K-12 : B0927; hypothetical protein 973489 ycbL 1077396 ycbL Shigella flexneri 2a str. 2457T hypothetical protein NP_836633.1 972842 D 198215 CDS NP_836634.1 30062463 1077370 complement(973712..974902) 1 NC_004741.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 974902 aspC 1077370 aspC Shigella flexneri 2a str. 2457T aromatic amino acid aminotransferase NP_836634.1 973712 R 198215 CDS NP_836635.1 30062464 1077397 complement(975087..976175) 1 NC_004741.1 outer membrane porin F; 1a; Ia; b; outer membrane protein F 976175 ompF 1077397 ompF Shigella flexneri 2a str. 2457T outer membrane protein F NP_836635.1 975087 R 198215 CDS NP_836636.1 30062465 1077398 complement(976776..978176) 1 NC_004741.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 978176 asnC 1077398 asnC Shigella flexneri 2a str. 2457T asparaginyl-tRNA synthetase NP_836636.1 976776 R 198215 CDS NP_836637.1 30062466 1077392 complement(978345..979547) 1 NC_004741.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 979547 pncB 1077392 pncB Shigella flexneri 2a str. 2457T nicotinate phosphoribosyltransferase NP_836637.1 978345 R 198215 CDS NP_836638.1 30062467 1077399 979813..982428 1 NC_004741.1 residues 1 to 871 of 871 are 95.63 pct identical to residues 1 to 870 of 870 from Escherichia coli K-12 : B0932; aminopeptidase N 982428 pepN 1077399 pepN Shigella flexneri 2a str. 2457T aminopeptidase N NP_836638.1 979813 D 198215 CDS NP_836639.1 30062468 1077400 complement(982635..983402) 1 NC_004741.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit 983402 ssuB 1077400 ssuB Shigella flexneri 2a str. 2457T aliphatic sulfonates transport ATP-binding subunit NP_836639.1 982635 R 198215 CDS NP_836640.2 161486519 1077403 complement(984027..984932) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 984932 1077403 S0996 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_836640.2 984027 R 198215 CDS NP_836641.2 161486518 1077404 complement(984890..985255) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 985255 1077404 S0997 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_836641.2 984890 R 198215 CDS NP_836642.1 30062471 1077423 complement(985538..986683) 1 NC_004741.1 catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 986683 ycbN 1077423 ycbN Shigella flexneri 2a str. 2457T alkanesulfonate monooxygenase NP_836642.1 985538 R 198215 CDS NP_836643.2 161486517 1077405 complement(986680..987639) 1 NC_004741.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 987639 ycbO 1077405 ycbO Shigella flexneri 2a str. 2457T alkanesulfonate transporter substrate-binding subunit NP_836643.2 986680 R 198215 CDS NP_836644.1 30062473 1077406 complement(987632..988207) 1 NC_004741.1 residues 1 to 191 of 191 are 92.67 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B0937; NAD(P)H-dependent FMN reductase 988207 ycbP 1077406 ycbP Shigella flexneri 2a str. 2457T NAD(P)H-dependent FMN reductase NP_836644.1 987632 R 198215 CDS NP_836645.1 30062474 1077407 988345..989040 1 NC_004741.1 residues 78 to 231 of 231 are 82.46 pct identical to residues 16 to 167 of 167 from GenPept : >gb|AAK18538.1|AF348706_227 (AF348706) IS1 orfB [Shigella flexneri]; partial; IS1 orfB, A 989040 1077407 S1002 Shigella flexneri 2a str. 2457T IS1 orfB, A NP_836645.1 988345 D 198215 CDS NP_836646.1 30062475 1077409 complement(989411..989914) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 989914 1077409 S1004 Shigella flexneri 2a str. 2457T IS1 orfB NP_836646.1 989411 R 198215 CDS NP_836647.1 30062476 1077410 complement(989833..990108) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 990108 1077410 S1005 Shigella flexneri 2a str. 2457T IS1 orfA NP_836647.1 989833 R 198215 CDS NP_836648.1 30062477 1080983 990248..992848 1 NC_004741.1 residues 1 to 866 of 866 are 94.91 pct identical to residues 1 to 866 of 866 from Escherichia coli K-12 : B0940; outer membrane protein 992848 ycbS 1080983 ycbS Shigella flexneri 2a str. 2457T outer membrane protein NP_836648.1 990248 D 198215 CDS NP_836649.1 30062478 1077411 992839..993822 1 NC_004741.1 residues 1 to 325 of 327 are 89.84 pct identical to residues 1 to 325 of 356 from Escherichia coli K-12 : B0941; fimbrial protein 993822 1077411 S1007 Shigella flexneri 2a str. 2457T fimbrial protein NP_836649.1 992839 D 198215 CDS NP_836650.1 30062479 1077412 993920..994462 1 NC_004741.1 residues 1 to 180 of 180 are 92.22 pct identical to residues 1 to 180 of 180 from Escherichia coli K-12 : B0942; fimbrial-like protein 994462 1077412 S1008 Shigella flexneri 2a str. 2457T fimbrial-like protein NP_836650.1 993920 D 198215 CDS NP_836651.1 30062480 1077413 994422..994985 1 NC_004741.1 residues 1 to 187 of 187 are 90.90 pct identical to residues 1 to 187 of 187 from Escherichia coli K-12 : B0943; fimbrial-like protein 994985 1077413 S1009 Shigella flexneri 2a str. 2457T fimbrial-like protein NP_836651.1 994422 D 198215 CDS NP_836652.1 30062481 1077414 994951..995688 1 NC_004741.1 residues 1 to 245 of 245 are 82.85 pct identical to residues 1 to 245 of 245 from Escherichia coli K-12 : B0944; putativi pili assembly chaperone 995688 ycbF 1077414 ycbF Shigella flexneri 2a str. 2457T putativi pili assembly chaperone NP_836652.1 994951 D 198215 CDS NP_836653.1 30062482 1077415 995800..996810 1 NC_004741.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 996810 pyrD 1077415 pyrD Shigella flexneri 2a str. 2457T dihydroorotate dehydrogenase 2 NP_836653.1 995800 D 198215 CDS NP_836654.1 30062483 1077416 996948..997526 1 NC_004741.1 residues 1 to 192 of 192 are 99.47 pct identical to residues 1 to 192 of 192 from Escherichia coli K-12 : B0946; hypothetical protein 997526 ycbW 1077416 ycbW Shigella flexneri 2a str. 2457T hypothetical protein NP_836654.1 996948 D 198215 CDS NP_836655.1 30062484 1077419 complement(997523..998632) 1 NC_004741.1 residues 1 to 369 of 369 are 95.66 pct identical to residues 1 to 369 of 369 from Escherichia coli K-12 : B0947; hypothetical protein 998632 1077419 S1013 Shigella flexneri 2a str. 2457T hypothetical protein NP_836655.1 997523 R 198215 CDS NP_836656.1 30062485 1077420 998876..1000984 1 NC_004741.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1000984 rlmL 1077420 rlmL Shigella flexneri 2a str. 2457T 23S rRNA m(2)G2445 methyltransferase NP_836656.1 998876 D 198215 CDS NP_836657.1 30062486 1077561 1000996..1002903 1 NC_004741.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1002903 uup 1077561 uup Shigella flexneri 2a str. 2457T ABC transporter ATPase NP_836657.1 1000996 D 198215 CDS NP_836658.1 30062487 1077422 1003033..1004286 1 NC_004741.1 residues 1 to 417 of 417 are 96.40 pct identical to residues 1 to 417 of 417 from Escherichia coli K-12 : B0950; paraquat-inducible protein A 1004286 pqiA 1077422 pqiA Shigella flexneri 2a str. 2457T paraquat-inducible protein A NP_836658.1 1003033 D 198215 CDS NP_836659.1 30062488 1077516 1004291..1005931 1 NC_004741.1 residues 1 to 546 of 546 are 97.43 pct identical to residues 1 to 546 of 546 from Escherichia coli K-12 : B0951; paraquat-inducible protein B 1005931 pqiB 1077516 pqiB Shigella flexneri 2a str. 2457T paraquat-inducible protein B NP_836659.1 1004291 D 198215 CDS NP_836660.1 30062489 1077424 1005928..1006491 1 NC_004741.1 residues 6 to 187 of 187 are 99.45 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 : B0952; hypothetical protein 1006491 ymbA 1077424 ymbA Shigella flexneri 2a str. 2457T hypothetical protein NP_836660.1 1005928 D 198215 CDS NP_836661.1 30062490 1077425 1006747..1006914 1 NC_004741.1 residues 1 to 55 of 55 are 98.18 pct identical to residues 1 to 55 of 55 from Escherichia coli K-12 : B0953; ribosome modulation factor 1006914 rmf 1077425 rmf Shigella flexneri 2a str. 2457T ribosome modulation factor NP_836661.1 1006747 D 198215 CDS NP_836662.1 30062491 1077245 complement(1006984..1007502) 1 NC_004741.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase 1007502 fabA 1077245 fabA Shigella flexneri 2a str. 2457T 3-hydroxydecanoyl-ACP dehydratase NP_836662.1 1006984 R 198215 CDS NP_836663.1 30062492 1077426 complement(1007571..1009331) 1 NC_004741.1 residues 1 to 586 of 586 are 97.44 pct identical to residues 1 to 586 of 586 from Escherichia coli K-12 : B0955; ATP-dependent protease 1009331 1077426 S1021 Shigella flexneri 2a str. 2457T ATP-dependent protease NP_836663.1 1007571 R 198215 CDS NP_836664.1 30062493 1077427 1009516..1009968 1 NC_004741.1 residues 1 to 150 of 150 are 100.00 pct identical to residues 1 to 150 of 150 from Escherichia coli K-12 : B0956; hypothetical protein 1009968 ycbG 1077427 ycbG Shigella flexneri 2a str. 2457T hypothetical protein NP_836664.1 1009516 D 198215 CDS NP_836665.1 30062494 1077401 complement(1010044..1011090) 1 NC_004741.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A 1011090 ompA 1077401 ompA Shigella flexneri 2a str. 2457T outer membrane protein A NP_836665.1 1010044 R 198215 CDS NP_836666.1 30062495 1077428 complement(1011446..1011955) 1 NC_004741.1 residues 1 to 169 of 169 are 79.88 pct identical to residues 1 to 169 of 169 from Escherichia coli K-12 : B0958; suppressor of lon; SOS cell division inhibitor 1011955 sulA 1077428 sulA Shigella flexneri 2a str. 2457T SOS cell division inhibitor NP_836666.1 1011446 R 198215 CDS NP_836667.1 30062496 1077353 1012174..1012599 1 NC_004741.1 residues 1 to 137 of 141 are 100.00 pct identical to residues 1 to 137 of 209 from Escherichia coli K-12 : B0959; hypothetical protein 1012599 1077353 S1025 Shigella flexneri 2a str. 2457T hypothetical protein NP_836667.1 1012174 D 198215 CDS NP_836668.2 161486516 1080912 1012675..1013040 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1013040 1080912 S1026 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_836668.2 1012675 D 198215 CDS NP_836669.1 30062498 1077429 1013019..1013651 1 NC_004741.1 residues 1 to 195 of 195 are 98.97 pct identical to residues 23 to 217 of 301 from GenPept : >gb|AAL72414.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS2 orfB 1013651 1077429 S1027 Shigella flexneri 2a str. 2457T IS2 orfB NP_836669.1 1013019 D 198215 CDS NP_836670.1 30062499 1077430 complement(1013611..1015776) 1 NC_004741.1 residues 1 to 710 of 721 are 92.39 pct identical to residues 1 to 710 of 720 from Escherichia coli K-12 : B0960; hypothetical protein 1015776 1077430 S1028 Shigella flexneri 2a str. 2457T hypothetical protein NP_836670.1 1013611 R 198215 CDS NP_836671.1 30062500 1077431 complement(1015786..1016232) 1 NC_004741.1 residues 1 to 148 of 148 are 91.89 pct identical to residues 1 to 148 of 148 from Escherichia coli K-12 : B0961; hypothetical protein 1016232 yccF 1077431 yccF Shigella flexneri 2a str. 2457T hypothetical protein NP_836671.1 1015786 R 198215 CDS NP_836672.1 30062501 1077432 1016355..1018409 1 NC_004741.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1018409 helD 1077432 helD Shigella flexneri 2a str. 2457T DNA helicase IV NP_836672.1 1016355 D 198215 CDS NP_836673.2 161486515 1077433 complement(1018441..1018899) 1 NC_004741.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 1018899 mgsA 1077433 mgsA Shigella flexneri 2a str. 2457T methylglyoxal synthase NP_836673.2 1018441 R 198215 CDS NP_836674.1 30062503 1077434 complement(1018995..1019657) 1 NC_004741.1 residues 1 to 220 of 220 are 100.00 pct identical to residues 1 to 220 of 220 from Escherichia coli K-12 : B0964; hypothetical protein 1019657 1077434 S1032 Shigella flexneri 2a str. 2457T hypothetical protein NP_836674.1 1018995 R 198215 CDS NP_836675.1 30062504 1077435 1019776..1020243 1 NC_004741.1 residues 1 to 155 of 155 are 99.35 pct identical to residues 10 to 164 of 164 from Escherichia coli K-12 : B0965; hypothetical protein 1020243 1077435 S1033 Shigella flexneri 2a str. 2457T hypothetical protein NP_836675.1 1019776 D 198215 CDS NP_836676.1 30062505 1077436 complement(1020288..1020656) 1 NC_004741.1 residues 1 to 122 of 122 are 100.00 pct identical to residues 1 to 122 of 122 from Escherichia coli K-12 : B0966; hypothetical protein 1020656 yccV 1077436 yccV Shigella flexneri 2a str. 2457T hypothetical protein NP_836676.1 1020288 R 198215 CDS NP_836677.1 30062506 1077437 complement(1020663..1021766) 1 NC_004741.1 residues 1 to 367 of 367 are 97.00 pct identical to residues 1 to 367 of 367 from Escherichia coli K-12 : B0967; oxidoreductase 1021766 1077437 S1035 Shigella flexneri 2a str. 2457T oxidoreductase NP_836677.1 1020663 R 198215 CDS NP_836678.1 30062507 1077438 1021948..1022226 1 NC_004741.1 residues 1 to 92 of 92 are 97.82 pct identical to residues 1 to 92 of 92 from Escherichia coli K-12 : B0968; hypothetical protein 1022226 1077438 S1036 Shigella flexneri 2a str. 2457T hypothetical protein NP_836678.1 1021948 D 198215 CDS NP_836679.2 161486514 1077439 complement(1022223..1022552) 1 NC_004741.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 1022552 yccK 1077439 yccK Shigella flexneri 2a str. 2457T sulfur transfer protein TusE NP_836679.2 1022223 R 198215 CDS NP_836680.1 30062509 1077440 complement(1022643..1023302) 1 NC_004741.1 residues 1 to 219 of 219 are 99.54 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B0970; hypothetical protein 1023302 yccA 1077440 yccA Shigella flexneri 2a str. 2457T hypothetical protein NP_836680.1 1022643 R 198215 CDS NP_836681.1 30062510 1077442 1024022..1025140 1 NC_004741.1 residues 1 to 372 of 372 are 91.12 pct identical to residues 1 to 372 of 372 from Escherichia coli K-12 : B0972; hydrogenase-1 small subunit 1025140 hyaA 1077442 hyaA Shigella flexneri 2a str. 2457T hydrogenase-1 small subunit NP_836681.1 1024022 D 198215 CDS NP_836682.1 30062511 1077443 1025137..1026930 1 NC_004741.1 involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1026930 hyaB 1077443 hyaB Shigella flexneri 2a str. 2457T hydrogenase 1 large subunit NP_836682.1 1025137 D 198215 CDS NP_836683.1 30062512 1077444 1026949..1027656 1 NC_004741.1 residues 1 to 235 of 235 are 99.57 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B0974; hydrogenase 1 b-type cytochrome subunit 1027656 hyaC 1077444 hyaC Shigella flexneri 2a str. 2457T hydrogenase 1 b-type cytochrome subunit NP_836683.1 1026949 D 198215 CDS NP_836684.1 30062513 1077445 1027653..1028240 1 NC_004741.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1028240 hyaD 1077445 hyaD Shigella flexneri 2a str. 2457T hydrogenase 1 maturation protease NP_836684.1 1027653 D 198215 CDS NP_836685.1 30062514 1077446 1028237..1028635 1 NC_004741.1 involved in processing hydrogenases HyaA and HyaB; hydrogenase-1 operon protein HyaE 1028635 hyaE 1077446 hyaE Shigella flexneri 2a str. 2457T hydrogenase-1 operon protein HyaE NP_836685.1 1028237 D 198215 CDS NP_836686.1 30062515 1077447 1028632..1029489 1 NC_004741.1 residues 1 to 285 of 285 are 95.08 pct identical to residues 1 to 285 of 285 from Escherichia coli K-12 : B0977; hydrogenase-1 operon protein hyaF 1029489 hyaF 1077447 hyaF Shigella flexneri 2a str. 2457T hydrogenase-1 operon protein hyaF NP_836686.1 1028632 D 198215 CDS NP_836687.1 30062516 1077448 1029623..1031167 1 NC_004741.1 residues 1 to 514 of 514 are 96.69 pct identical to residues 1 to 514 of 514 from Escherichia coli K-12 : B0978; third cytochrome oxidase, subunit I 1031167 appC 1077448 appC Shigella flexneri 2a str. 2457T third cytochrome oxidase, subunit I NP_836687.1 1029623 D 198215 CDS NP_836688.1 30062517 1077449 1031179..1032315 1 NC_004741.1 residues 1 to 378 of 378 are 91.00 pct identical to residues 1 to 378 of 378 from Escherichia coli K-12 : B0979; third cytochrome oxidase, subunit II 1032315 appB 1077449 appB Shigella flexneri 2a str. 2457T third cytochrome oxidase, subunit II NP_836688.1 1031179 D 198215 CDS NP_836689.1 30062518 1077450 1032499..1033797 1 NC_004741.1 residues 18 to 432 of 432 are 95.18 pct identical to residues 18 to 432 of 432 from Escherichia coli K-12 : B0980; phosphoanhydride phosphorylase 1033797 appA 1077450 appA Shigella flexneri 2a str. 2457T phosphoanhydride phosphorylase NP_836689.1 1032499 D 198215 CDS NP_836690.2 161486513 1077452 complement(1036098..1036544) 1 NC_004741.1 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase 1036544 etp 1077452 etp Shigella flexneri 2a str. 2457T phosphotyrosine-protein phosphatase NP_836690.2 1036098 R 198215 CDS NP_836691.1 30062520 1077453 complement(1036532..1037671) 1 NC_004741.1 residues 1 to 379 of 379 are 100.00 pct identical to residues 1 to 379 of 379 from Escherichia coli K-12 : B0983; involved in exopolysaccharide production; exopolysaccharide export protein 1037671 yccZ 1077453 yccZ Shigella flexneri 2a str. 2457T exopolysaccharide export protein NP_836691.1 1036532 R 198215 CDS NP_836692.1 30062521 1077454 complement(1037717..1039813) 1 NC_004741.1 residues 1 to 698 of 698 are 98.85 pct identical to residues 1 to 698 of 698 from Escherichia coli K-12 : B0984; hypothetical protein 1039813 ymcA 1077454 ymcA Shigella flexneri 2a str. 2457T hypothetical protein NP_836692.1 1037717 R 198215 CDS NP_836693.1 30062522 1077455 complement(1039813..1040559) 1 NC_004741.1 residues 1 to 248 of 248 are 99.59 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 : B0985; hypothetical protein 1040559 ymcB 1077455 ymcB Shigella flexneri 2a str. 2457T hypothetical protein NP_836693.1 1039813 R 198215 CDS NP_836694.1 30062523 1077456 complement(1040556..1041200) 1 NC_004741.1 residues 1 to 214 of 214 are 89.71 pct identical to residues 1 to 214 of 214 from Escherichia coli K-12 : B0986; regulator 1041200 ymcC 1077456 ymcC Shigella flexneri 2a str. 2457T regulator NP_836694.1 1040556 R 198215 CDS NP_836695.1 30062524 1077457 complement(1041307..1041630) 1 NC_004741.1 residues 1 to 107 of 107 are 28.97 pct identical to residues 1 to 107 of 107 from Escherichia coli K-12 : B0987; hypothetical protein 1041630 ymcD 1077457 ymcD Shigella flexneri 2a str. 2457T hypothetical protein NP_836695.1 1041307 R 198215 CDS NP_836696.1 30062525 1077458 complement(1042054..1042266) 1 NC_004741.1 residues 1 to 70 of 70 are 100.00 pct identical to residues 1 to 70 of 70 from Escherichia coli K-12 : B0989; cold shock-like protein 1042266 cspH 1077458 cspH Shigella flexneri 2a str. 2457T cold shock-like protein NP_836696.1 1042054 R 198215 CDS NP_836697.1 30062526 1077459 1042621..1042896 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1042896 1077459 S1058 Shigella flexneri 2a str. 2457T IS1 orfA NP_836697.1 1042621 D 198215 CDS NP_836698.1 30062527 1077460 1042815..1043318 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1043318 1077460 S1059 Shigella flexneri 2a str. 2457T IS1 orfB NP_836698.1 1042815 D 198215 CDS NP_836699.1 30062528 1077461 1043340..1043540 1 NC_004741.1 residues 2 to 71 of 71 are 97.14 pct identical to residues 1 to 70 of 70 from Escherichia coli K-12 : B0990; cold shock protein CspG 1043540 cspG 1077461 cspG Shigella flexneri 2a str. 2457T cold shock protein CspG NP_836699.1 1043340 D 198215 CDS NP_836700.1 30062529 1077462 1043714..1043944 1 NC_004741.1 residues 1 to 76 of 76 are 96.05 pct identical to residues 1 to 76 of 76 from Escherichia coli K-12 : B0991; cold shock gene 1043944 ymcE 1077462 ymcE Shigella flexneri 2a str. 2457T cold shock gene NP_836700.1 1043714 D 198215 CDS NP_836701.1 30062530 1077463 complement(1044156..1045229) 1 NC_004741.1 residues 1 to 357 of 357 are 95.23 pct identical to residues 1 to 357 of 357 from Escherichia coli K-12 : B0992; hypothetical protein 1045229 yccM 1077463 yccM Shigella flexneri 2a str. 2457T hypothetical protein NP_836701.1 1044156 R 198215 CDS NP_836702.1 30062531 1077465 1048125..1049153 1 NC_004741.1 periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1049153 torT 1077465 torT Shigella flexneri 2a str. 2457T TMAO reductase system periplasmic protein TorT NP_836702.1 1048125 D 198215 CDS NP_836703.1 30062532 1077466 complement(1049126..1049818) 1 NC_004741.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 1049818 torR 1077466 torR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator TorR NP_836703.1 1049126 R 198215 CDS NP_836704.1 30062533 1077467 1049905..1051077 1 NC_004741.1 residues 1 to 390 of 390 are 94.87 pct identical to residues 1 to 390 of 390 from Escherichia coli K-12 : B0996; trimethylamine N-oxide reductase, cytochrome c-type subunit 1051077 torC 1077467 torC Shigella flexneri 2a str. 2457T trimethylamine N-oxide reductase, cytochrome c-type subunit NP_836704.1 1049905 D 198215 CDS NP_836705.1 30062534 1077470 complement(1053820..1054323) 1 NC_004741.1 residues 1 to 167 of 167 are 89.22 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1054323 1077470 S1069 Shigella flexneri 2a str. 2457T IS1 orfB NP_836705.1 1053820 R 198215 CDS NP_836706.1 30062535 1078500 complement(1054242..1054517) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1054517 1078500 S1070 Shigella flexneri 2a str. 2457T IS1 orfA NP_836706.1 1054242 R 198215 CDS NP_836707.1 30062536 1077471 complement(1055083..1055388) 1 NC_004741.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 1055388 yccD 1077471 yccD Shigella flexneri 2a str. 2457T chaperone-modulator protein CbpM NP_836707.1 1055083 R 198215 CDS NP_836708.1 30062537 1077472 complement(1055388..1056308) 1 NC_004741.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 1056308 cbpA 1077472 cbpA Shigella flexneri 2a str. 2457T curved DNA-binding protein CbpA NP_836708.1 1055388 R 198215 CDS NP_836709.1 30062538 1077473 1056569..1057825 1 NC_004741.1 residues 1 to 417 of 418 are 88.00 pct identical to residues 1 to 417 of 418 from Escherichia coli K-12 : B1001; hypothetical protein 1057825 yccE 1077473 yccE Shigella flexneri 2a str. 2457T hypothetical protein NP_836709.1 1056569 D 198215 CDS NP_836710.1 30062539 1077474 1058118..1059359 1 NC_004741.1 residues 1 to 413 of 413 are 98.54 pct identical to residues 1 to 413 of 413 from Escherichia coli K-12 : B1002; glucose-1-phosphatase/inositol phosphatase 1059359 agp 1077474 agp Shigella flexneri 2a str. 2457T glucose-1-phosphatase/inositol phosphatase NP_836710.1 1058118 D 198215 CDS NP_836711.1 30062540 1076625 complement(1059397..1059624) 1 NC_004741.1 residues 1 to 75 of 75 are 100.00 pct identical to residues 1 to 75 of 75 from Escherichia coli K-12 : B1003; hypothetical protein 1059624 yccJ 1076625 yccJ Shigella flexneri 2a str. 2457T hypothetical protein NP_836711.1 1059397 R 198215 CDS NP_836712.1 30062541 1077475 complement(1059645..1060241) 1 NC_004741.1 stationary phase that binds TrpR repressor; TrpR binding protein WrbA 1060241 wrbA 1077475 wrbA Shigella flexneri 2a str. 2457T TrpR binding protein WrbA NP_836712.1 1059645 R 198215 CDS NP_836713.1 30062542 1077476 1060451..1060681 1 NC_004741.1 residues 1 to 76 of 76 are 61.84 pct identical to residues 1 to 76 of 76 from Escherichia coli K-12 : B1005; hypothetical protein 1060681 ycdF 1077476 ycdF Shigella flexneri 2a str. 2457T hypothetical protein NP_836713.1 1060451 D 198215 CDS NP_836714.1 30062543 1077477 complement(1060803..1062197) 1 NC_004741.1 residues 1 to 464 of 464 are 92.24 pct identical to residues 1 to 464 of 464 from Escherichia coli K-12 : B1006; transporter 1062197 ycdG 1077477 ycdG Shigella flexneri 2a str. 2457T transporter NP_836714.1 1060803 R 198215 CDS NP_836715.1 30062544 1077478 complement(1062152..1062610) 1 NC_004741.1 residues 1 to 152 of 152 are 99.34 pct identical to residues 1 to 152 of 152 from Escherichia coli K-12 : B1007; hypothetical protein 1062610 1077478 S1080 Shigella flexneri 2a str. 2457T hypothetical protein NP_836715.1 1062152 R 198215 CDS NP_836716.1 30062545 1077479 complement(1062657..1063247) 1 NC_004741.1 residues 1 to 196 of 196 are 97.44 pct identical to residues 1 to 196 of 196 from Escherichia coli K-12 : B1008; hypothetical protein 1063247 1077479 S1081 Shigella flexneri 2a str. 2457T hypothetical protein NP_836716.1 1062657 R 198215 CDS NP_836717.1 30062546 1077480 complement(1063257..1064057) 1 NC_004741.1 residues 1 to 266 of 266 are 83.83 pct identical to residues 1 to 266 of 266 from Escherichia coli K-12 : B1009; acetyltransferase 1064057 1077480 S1082 Shigella flexneri 2a str. 2457T acetyltransferase NP_836717.1 1063257 R 198215 CDS NP_836718.1 30062547 1077481 complement(1064065..1064451) 1 NC_004741.1 residues 1 to 128 of 128 are 99.21 pct identical to residues 1 to 128 of 128 from Escherichia coli K-12 : B1010; hypothetical protein 1064451 1077481 S1083 Shigella flexneri 2a str. 2457T hypothetical protein NP_836718.1 1064065 R 198215 CDS NP_836719.1 30062548 1077482 complement(1064463..1065197) 1 NC_004741.1 residues 1 to 244 of 244 are 97.95 pct identical to residues 1 to 244 of 244 from Escherichia coli K-12 : B1011; synthetase 1065197 1077482 S1084 Shigella flexneri 2a str. 2457T synthetase NP_836719.1 1064463 R 198215 CDS NP_836720.1 30062549 1077483 complement(1065155..1066303) 1 NC_004741.1 residues 1 to 382 of 382 are 95.54 pct identical to residues 1 to 382 of 382 from Escherichia coli K-12 : B1012; hypothetical protein 1066303 1077483 S1085 Shigella flexneri 2a str. 2457T hypothetical protein NP_836720.1 1065155 R 198215 CDS NP_836721.1 30062550 1077484 1066534..1067172 1 NC_004741.1 residues 1 to 212 of 212 are 91.50 pct identical to residues 1 to 212 of 212 from Escherichia coli K-12 : B1013; tet operon regulator 1067172 ycdC 1077484 ycdC Shigella flexneri 2a str. 2457T tet operon regulator NP_836721.1 1066534 D 198215 CDS NP_836722.1 30062551 1077485 complement(1067466..1068653) 1 NC_004741.1 residues 1 to 388 of 395 are 97.16 pct identical to residues 1 to 388 of 406 from GenPept : >gb|AAK85176.1| (AF294823) transposase [Shigella sonnei]; IS91 1068653 1077485 S1087 Shigella flexneri 2a str. 2457T IS91 NP_836722.1 1067466 R 198215 CDS NP_836723.1 30062552 1077486 complement(1068670..1069017) 1 NC_004741.1 residues 1 to 115 of 115 are 89.56 pct identical to residues 1 to 115 of 121 from GenPept : >emb|CAC14584.1| (X17114) ORF 121 [Escherichia coli]; IS91 1069017 1077486 S1088 Shigella flexneri 2a str. 2457T IS91 NP_836723.1 1068670 R 198215 CDS NP_836724.1 30062553 1077487 1069073..1069780 1 NC_004741.1 residues 12 to 235 of 235 are 91.96 pct identical to residues 20 to 243 of 243 from Escherichia coli K-12 : B1017; cytochrome 1069780 1077487 S1089 Shigella flexneri 2a str. 2457T cytochrome NP_836724.1 1069073 D 198215 CDS NP_836725.1 30062554 1077488 1069838..1070965 1 NC_004741.1 residues 1 to 375 of 375 are 95.46 pct identical to residues 1 to 375 of 375 from Escherichia coli K-12 : B1018; hypothetical protein 1070965 ycdO 1077488 ycdO Shigella flexneri 2a str. 2457T hypothetical protein NP_836725.1 1069838 D 198215 CDS NP_836726.1 30062555 1077489 1070971..1072236 1 NC_004741.1 residues 1 to 421 of 421 are 97.87 pct identical to residues 1 to 423 of 423 from Escherichia coli K-12 : B1019; hypothetical protein 1072236 ycdB 1077489 ycdB Shigella flexneri 2a str. 2457T hypothetical protein NP_836726.1 1070971 D 198215 CDS NP_836727.1 30062556 1077491 complement(1073741..1074607) 1 NC_004741.1 residues 1 to 288 of 288 are 100.00 pct identical to residues 1 to 288 of 288 from GenPept : >gb|AAL57519.1|AF453441_3 (AF453441) transposase 1 [Escherichia coli]; IS3 orfB 1074607 1077491 S1093 Shigella flexneri 2a str. 2457T IS3 orfB NP_836727.1 1073741 R 198215 CDS NP_836728.1 30062557 1077492 complement(1074604..1074903) 1 NC_004741.1 residues 1 to 99 of 99 are 100.00 pct identical to residues 1 to 99 of 99 from GenPept : >gb|AAL57580.1|AF453442_9 (AF453442) transposase 2 [Escherichia coli]; IS3 orfA 1074903 1077492 S1094 Shigella flexneri 2a str. 2457T IS3 orfA NP_836728.1 1074604 R 198215 CDS NP_836729.1 30062558 1077494 1075495..1076481 1 NC_004741.1 residues 1 to 328 of 328 are 94.20 pct identical to residues 1 to 328 of 328 from Escherichia coli K-12 : B1029; hypothetical protein 1076481 ycdU 1077494 ycdU Shigella flexneri 2a str. 2457T hypothetical protein NP_836729.1 1075495 D 198215 CDS NP_836730.1 30062559 1077499 1077989..1078726 1 NC_004741.1 residues 1 to 245 of 245 are 87.34 pct identical to residues 1 to 245 of 245 from Escherichia coli K-12 : B1034; hydrolase 1078726 ycdX 1077499 ycdX Shigella flexneri 2a str. 2457T hydrolase NP_836730.1 1077989 D 198215 CDS NP_836731.1 30062560 1077500 1078750..1079304 1 NC_004741.1 residues 1 to 184 of 184 are 99.45 pct identical to residues 1 to 184 of 184 from Escherichia coli K-12 : B1035; oxidoreductase component 1079304 ycdY 1077500 ycdY Shigella flexneri 2a str. 2457T oxidoreductase component NP_836731.1 1078750 D 198215 CDS NP_836732.1 30062561 1077501 1079376..1079897 1 NC_004741.1 residues 1 to 173 of 173 are 99.42 pct identical to residues 7 to 179 of 179 from Escherichia coli K-12 : B1036; hypothetical protein 1079897 ycdZ 1077501 ycdZ Shigella flexneri 2a str. 2457T hypothetical protein NP_836732.1 1079376 D 198215 CDS NP_836733.1 30062562 1077503 complement(1080763..1081179) 1 NC_004741.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 1081179 csgF 1077503 csgF Shigella flexneri 2a str. 2457T curli assembly protein CsgF NP_836733.1 1080763 R 198215 CDS NP_836734.1 30062563 1077504 complement(1081204..1081593) 1 NC_004741.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 1081593 csgE 1077504 csgE Shigella flexneri 2a str. 2457T curli assembly protein CsgE NP_836734.1 1081204 R 198215 CDS NP_836735.1 30062564 1077505 complement(1081598..1082248) 1 NC_004741.1 activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 1082248 csgD 1077505 csgD Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator CsgD NP_836735.1 1081598 R 198215 CDS NP_836736.1 30062565 1077506 1083002..1083457 1 NC_004741.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1083457 csgB 1077506 csgB Shigella flexneri 2a str. 2457T curlin minor subunit NP_836736.1 1083002 D 198215 CDS NP_836737.1 30062566 1077508 1083671..1083973 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 1083973 1077508 S1110 Shigella flexneri 2a str. 2457T IS600 NP_836737.1 1083671 D 198215 CDS NP_836738.1 30062567 1077509 1084114..1084752 1 NC_004741.1 residues 1 to 181 of 212 are 88.39 pct identical to residues 36 to 216 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 ORF2 1084752 1077509 S1111 Shigella flexneri 2a str. 2457T IS600 ORF2 NP_836738.1 1084114 D 198215 CDS NP_836739.1 30062568 1077510 1085157..1085489 1 NC_004741.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers; autoagglutination protein 1085489 csgC 1077510 csgC Shigella flexneri 2a str. 2457T autoagglutination protein NP_836739.1 1085157 D 198215 CDS NP_836740.1 30062569 1077511 1085610..1085921 1 NC_004741.1 residues 1 to 103 of 103 are 98.05 pct identical to residues 1 to 103 of 103 from Escherichia coli K-12 : B1044; hypothetical protein 1085921 1077511 S1114 Shigella flexneri 2a str. 2457T hypothetical protein NP_836740.1 1085610 D 198215 CDS NP_836741.1 30062570 1077512 1086016..1086549 1 NC_004741.1 residues 1 to 177 of 177 are 99.43 pct identical to residues 1 to 177 of 177 from Escherichia coli K-12 : B1045; hypothetical protein 1086549 1077512 S1115 Shigella flexneri 2a str. 2457T hypothetical protein NP_836741.1 1086016 D 198215 CDS NP_836742.1 30062571 1077513 1086491..1087972 1 NC_004741.1 residues 1 to 493 of 493 are 99.79 pct identical to residues 1 to 493 of 493 from Escherichia coli K-12 : B1046; synthase 1087972 ymdC 1077513 ymdC Shigella flexneri 2a str. 2457T synthase NP_836742.1 1086491 D 198215 CDS NP_836743.1 30062572 1077514 complement(1087980..1089137) 1 NC_004741.1 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 1089137 mdoC 1077514 mdoC Shigella flexneri 2a str. 2457T glucans biosynthesis protein NP_836743.1 1087980 R 198215 CDS NP_836744.1 30062573 1077515 1089531..1091066 1 NC_004741.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1091066 mdoG 1077515 mdoG Shigella flexneri 2a str. 2457T glucan biosynthesis protein G NP_836744.1 1089531 D 198215 CDS NP_836745.1 30062574 1077517 1091059..1093602 1 NC_004741.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1093602 mdoH 1077517 mdoH Shigella flexneri 2a str. 2457T glucosyltransferase MdoH NP_836745.1 1091059 D 198215 CDS NP_836746.1 30062575 1077518 complement(1094152..1095207) 1 NC_004741.1 residues 1 to 351 of 351 are 98.00 pct identical to residues 1 to 351 of 406 from GenPept : >gb|AAK85176.1| (AF294823) transposase [Shigella sonnei]; IS91 orf 1095207 1077518 S1120 Shigella flexneri 2a str. 2457T IS91 orf NP_836746.1 1094152 R 198215 CDS NP_836747.1 30062576 1077519 complement(1095207..1095629) 1 NC_004741.1 residues 1 to 140 of 140 are 100.00 pct identical to residues 1 to 140 of 140 from NRprotein_Feb03 : >ref|NP_706937.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301] ref|NP_706962.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301] ref|NP_707627.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN42644.1|AE015130_3 orf, conserved hypo; hypothetical protein 1095629 1077519 S4816 Shigella flexneri 2a str. 2457T hypothetical protein NP_836747.1 1095207 R 198215 CDS NP_836748.1 30062577 1076637 1095591..1096931 1 NC_004741.1 residues 22 to 289 of 446 are 25.09 pct identical to residues 246 to 502 of 1525 from NRprotein_Feb03 : >ref|NP_395347.1| membrane protein [Yersinia pestis] pir||T14961 hypothetical protein Y1044 - Yersinia pestis plasmid pMT1 gb|AAC13170.1| protein HI1514 homolog [Yersinia pestis] gb|AAC82704.1| unknown [Yersinia pestis] emb|CAB55193.1| membrane protein [Yersinia pestis]; hypothetical protein 1096931 1076637 S4815 Shigella flexneri 2a str. 2457T hypothetical protein NP_836748.1 1095591 D 198215 CDS NP_836749.1 30062578 1077520 1096928..1097200 1 NC_004741.1 no significant similarities; hypothetical protein 1097200 1077520 S4817 Shigella flexneri 2a str. 2457T hypothetical protein NP_836749.1 1096928 D 198215 CDS NP_836750.1 30062579 1077521 complement(1097304..1097924) 1 NC_004741.1 residues 1 to 206 of 206 are 99.51 pct identical to residues 1 to 206 of 206 from GenPept : >gb|AAD44736.1|AF141323_7 (AF141323) TnpC [Shigella flexneri]; partial; IS629 orfB 1097924 1077521 S1123 Shigella flexneri 2a str. 2457T IS629 orfB NP_836750.1 1097304 R 198215 CDS NP_836751.1 30062580 1077522 complement(1098187..1098513) 1 NC_004741.1 residues 1 to 108 of 108 are 89.81 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72456.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA 1098513 1077522 S1124 Shigella flexneri 2a str. 2457T IS629 orfA NP_836751.1 1098187 R 198215 CDS NP_836752.1 30062581 1077523 1098945..1099247 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 1099247 1077523 S1126 Shigella flexneri 2a str. 2457T IS911 orfA NP_836752.1 1098945 D 198215 CDS NP_836753.1 30062582 1077524 1099436..1100113 1 NC_004741.1 residues 1 to 225 of 225 are 100.00 pct identical to residues 55 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; IS911 orfB 1100113 1077524 S1127 Shigella flexneri 2a str. 2457T IS911 orfB NP_836753.1 1099436 D 198215 CDS NP_836754.1 30062583 1077525 complement(1100131..1100553) 1 NC_004741.1 no significant similarities; hypothetical protein 1100553 1077525 S1128 Shigella flexneri 2a str. 2457T hypothetical protein NP_836754.1 1100131 R 198215 CDS NP_836755.2 161486512 1077526 1100686..1101051 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1101051 1077526 S1129 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_836755.2 1100686 D 198215 CDS NP_836756.2 161486511 1077527 1101009..1101914 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1101914 1077527 S1130 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_836756.2 1101009 D 198215 CDS NP_836757.1 30062586 1077528 1102310..1102636 1 NC_004741.1 residues 1 to 108 of 108 are 89.81 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72456.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA 1102636 1077528 S1131 Shigella flexneri 2a str. 2457T IS629 orfA NP_836757.1 1102310 D 198215 CDS NP_836758.1 30062587 1077529 1102872..1103519 1 NC_004741.1 residues 1 to 215 of 215 are 99.06 pct identical to residues 1 to 215 of 215 from GenPept : >gb|AAK18507.1|AF348706_196 (AF348706) IS629 orf [Shigella flexneri]; partial; IS629 orfB 1103519 1077529 S1132 Shigella flexneri 2a str. 2457T IS629 orfB NP_836758.1 1102872 D 198215 CDS NP_836759.1 30062588 1077530 1103807..1104109 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 1104109 1077530 S1133 Shigella flexneri 2a str. 2457T IS600 orfA NP_836759.1 1103807 D 198215 CDS NP_836760.1 30062589 1077531 1104250..1104729 1 NC_004741.1 residues 1 to 144 of 159 are 85.41 pct identical to residues 36 to 179 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS600 orfB 1104729 1077531 S1134 Shigella flexneri 2a str. 2457T IS600 orfB NP_836760.1 1104250 D 198215 CDS NP_836761.1 30062590 1077532 1104738..1104962 1 NC_004741.1 residues 1 to 74 of 74 are 98.64 pct identical to residues 73 to 146 of 146 from GenPept : >gb|AAL72524.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS600 orfB 1104962 1077532 S1135 Shigella flexneri 2a str. 2457T IS600 orfB NP_836761.1 1104738 D 198215 CDS NP_836762.1 30062591 1077533 complement(1104987..1105919) 1 NC_004741.1 residues 1 to 306 of 310 are 43.31 pct identical to residues 1 to 310 of 508 from GenPept : >gb|AAG55968.1|AE005329_12 (AE005329) unknown protein encoded by prophage CP-933X [Escherichia coli O157:H7 EDL933]; hypothetical protein 1105919 1077533 S1136 Shigella flexneri 2a str. 2457T hypothetical protein NP_836762.1 1104987 R 198215 CDS NP_836763.1 30062592 1077535 complement(1106312..1107232) 1 NC_004741.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1107232 htrB 1077535 htrB Shigella flexneri 2a str. 2457T lipid A biosynthesis lauroyl acyltransferase NP_836763.1 1106312 R 198215 CDS NP_836764.1 30062593 1077536 1107457..1108509 1 NC_004741.1 residues 1 to 350 of 350 are 99.71 pct identical to residues 1 to 350 of 350 from Escherichia coli K-12 : B1055; hypothetical protein 1108509 yceA 1077536 yceA Shigella flexneri 2a str. 2457T hypothetical protein NP_836764.1 1107457 D 198215 CDS NP_836765.1 30062594 1077537 complement(1108551..1109126) 1 NC_004741.1 residues 1 to 191 of 191 are 92.67 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B1056; hypothetical protein 1109126 yceI 1077537 yceI Shigella flexneri 2a str. 2457T hypothetical protein NP_836765.1 1108551 R 198215 CDS NP_836766.1 30062595 1077538 complement(1109130..1109696) 1 NC_004741.1 residues 1 to 188 of 188 are 83.51 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 : B1057; cytochrome 1109696 1077538 S1141 Shigella flexneri 2a str. 2457T cytochrome NP_836766.1 1109130 R 198215 CDS NP_836767.1 30062596 1077539 complement(1109957..1110070) 1 NC_004741.1 residues 1 to 37 of 37 are 100.00 pct identical to residues 10 to 46 of 46 from Escherichia coli K-12 : B1058; hypothetical protein 1110070 yceO 1077539 yceO Shigella flexneri 2a str. 2457T hypothetical protein NP_836767.1 1109957 R 198215 CDS NP_836768.1 30062597 1077540 complement(1110118..1111236) 1 NC_004741.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 1111236 solA 1077540 solA Shigella flexneri 2a str. 2457T N-methyltryptophan oxidase NP_836768.1 1110118 R 198215 CDS NP_836769.2 161486510 1077541 complement(1111351..1111605) 1 NC_004741.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 1111605 bssS 1077541 bssS Shigella flexneri 2a str. 2457T biofilm formation regulatory protein BssS NP_836769.2 1111351 R 198215 CDS NP_836770.1 30062599 1077542 complement(1111895..1112140) 1 NC_004741.1 residues 1 to 81 of 81 are 100.00 pct identical to residues 1 to 81 of 81 from Escherichia coli K-12 : B1061; DNA damage-inducible protein I 1112140 dinI 1077542 dinI Shigella flexneri 2a str. 2457T DNA damage-inducible protein I NP_836770.1 1111895 R 198215 CDS NP_836771.1 30062600 1077543 complement(1112214..1113260) 1 NC_004741.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1113260 pyrC 1077543 pyrC Shigella flexneri 2a str. 2457T dihydroorotase NP_836771.1 1112214 R 198215 CDS NP_836772.1 30062601 1077544 complement(1113366..1113926) 1 NC_004741.1 residues 1 to 186 of 186 are 100.00 pct identical to residues 1 to 186 of 186 from Escherichia coli K-12 : B1063; hypothetical protein 1113926 yceB 1077544 yceB Shigella flexneri 2a str. 2457T hypothetical protein NP_836772.1 1113366 R 198215 CDS NP_836773.1 30062602 1077545 complement(1114060..1114707) 1 NC_004741.1 cofactor involved in the reduction of disulfides; glutaredoxin 1114707 grxB 1077545 grxB Shigella flexneri 2a str. 2457T glutaredoxin NP_836773.1 1114060 R 198215 CDS NP_836774.1 30062603 1077546 complement(1114771..1115979) 1 NC_004741.1 Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 1115979 yceL 1077546 yceL Shigella flexneri 2a str. 2457T multidrug resistance protein MdtH NP_836774.1 1114771 R 198215 CDS NP_836775.1 30062604 1077547 1116215..1116799 1 NC_004741.1 residues 1 to 194 of 194 are 100.00 pct identical to residues 1 to 194 of 194 from Escherichia coli K-12 : B1066; required for acetylation of N-terminal alanine of 30S ribosomal subunit protein S5; ribosomal-protein-S5-alanine N-acetyltransferase 1116799 rimJ 1077547 rimJ Shigella flexneri 2a str. 2457T ribosomal-protein-S5-alanine N-acetyltransferase NP_836775.1 1116215 D 198215 CDS NP_836776.1 30062605 1077548 1116810..1117457 1 NC_004741.1 residues 1 to 215 of 215 are 98.13 pct identical to residues 1 to 215 of 215 from Escherichia coli K-12 : B1067; hypothetical protein 1117457 yceH 1077548 yceH Shigella flexneri 2a str. 2457T hypothetical protein NP_836776.1 1116810 D 198215 CDS NP_836777.1 30062606 1077549 1117459..1118292 1 NC_004741.1 residues 1 to 277 of 277 are 94.58 pct identical to residues 1 to 277 of 307 from Escherichia coli K-12 : B1068; virulence factor 1118292 mviM 1077549 mviM Shigella flexneri 2a str. 2457T virulence factor NP_836777.1 1117459 D 198215 CDS NP_836778.1 30062607 1077577 1118492..1120027 1 NC_004741.1 residues 1 to 511 of 511 are 86.88 pct identical to residues 1 to 511 of 511 from Escherichia coli K-12 : B1069; virulence factor 1120027 mviN 1077577 mviN Shigella flexneri 2a str. 2457T virulence factor NP_836778.1 1118492 D 198215 CDS NP_836779.1 30062608 1077550 complement(1120067..1120483) 1 NC_004741.1 residues 1 to 138 of 138 are 97.82 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 : B1070; flagella synthesis protein FlgN 1120483 flgN 1077550 flgN Shigella flexneri 2a str. 2457T flagella synthesis protein FlgN NP_836779.1 1120067 R 198215 CDS NP_836780.1 30062609 1077551 complement(1120488..1120781) 1 NC_004741.1 regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM 1120781 flgM 1077551 flgM Shigella flexneri 2a str. 2457T anti-sigma28 factor FlgM NP_836780.1 1120488 R 198215 CDS NP_836781.1 30062610 1077552 complement(1120857..1121516) 1 NC_004741.1 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 1121516 flgA 1077552 flgA Shigella flexneri 2a str. 2457T flagellar basal body P-ring biosynthesis protein FlgA NP_836781.1 1120857 R 198215 CDS NP_836782.1 30062611 1077609 1121671..1122087 1 NC_004741.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal body rod protein FlgB 1122087 flgB 1077609 flgB Shigella flexneri 2a str. 2457T flagellar basal body rod protein FlgB NP_836782.1 1121671 D 198215 CDS NP_836783.1 30062612 1077554 1122506..1123201 1 NC_004741.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1123201 flgD 1077554 flgD Shigella flexneri 2a str. 2457T flagellar basal body rod modification protein NP_836783.1 1122506 D 198215 CDS NP_836784.1 30062613 1077555 1123226..1124434 1 NC_004741.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1124434 flgE 1077555 flgE Shigella flexneri 2a str. 2457T flagellar hook protein FlgE NP_836784.1 1123226 D 198215 CDS NP_836785.1 30062614 1077557 1125343..1126125 1 NC_004741.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1126125 flgG 1077557 flgG Shigella flexneri 2a str. 2457T flagellar basal body rod protein FlgG NP_836785.1 1125343 D 198215 CDS NP_836786.1 30062615 1077558 1126178..1126876 1 NC_004741.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1126876 flgH 1077558 flgH Shigella flexneri 2a str. 2457T flagellar basal body L-ring protein NP_836786.1 1126178 D 198215 CDS NP_836787.1 30062616 1077559 1126888..1127985 1 NC_004741.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 1127985 flgI 1077559 flgI Shigella flexneri 2a str. 2457T flagellar basal body P-ring protein NP_836787.1 1126888 D 198215 CDS NP_836788.1 30062617 1077560 1127985..1128926 1 NC_004741.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1128926 flgJ 1077560 flgJ Shigella flexneri 2a str. 2457T flagellar rod assembly protein/muramidase FlgJ NP_836788.1 1127985 D 198215 CDS NP_836789.2 161486509 1077565 complement(1131785..1134976) 1 NC_004741.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 1134976 rne 1077565 rne Shigella flexneri 2a str. 2457T ribonuclease E NP_836789.2 1131785 R 198215 CDS NP_836790.1 30062619 1077566 1135057..1135431 1 NC_004741.1 residues 1 to 124 of 124 are 87.09 pct identical to residues 1 to 124 of 124 from Escherichia coli K-12 : B1085; hypothetical protein 1135431 1077566 S1169 Shigella flexneri 2a str. 2457T hypothetical protein NP_836790.1 1135057 D 198215 CDS NP_836791.1 30062620 1077567 1135549..1136508 1 NC_004741.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1136508 yceC 1077567 yceC Shigella flexneri 2a str. 2457T 23S rRNA pseudouridylate synthase C NP_836791.1 1135549 D 198215 CDS NP_836792.2 161486508 1077568 complement(1136620..1137204) 1 NC_004741.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1137204 maf 1077568 maf Shigella flexneri 2a str. 2457T Maf-like protein NP_836792.2 1136620 R 198215 CDS NP_836793.1 30062622 1077591 1137403..1137924 1 NC_004741.1 residues 1 to 173 of 173 are 90.17 pct identical to residues 1 to 173 of 173 from Escherichia coli K-12 : B1088; hypothetical protein 1137924 yceD 1077591 yceD Shigella flexneri 2a str. 2457T hypothetical protein NP_836793.1 1137403 D 198215 CDS NP_836794.1 30062623 1077571 1137976..1138149 1 NC_004741.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1138149 rpmF 1077571 rpmF Shigella flexneri 2a str. 2457T 50S ribosomal protein L32 NP_836794.1 1137976 D 198215 CDS NP_836795.2 161486507 1080370 1138230..1139300 1 NC_004741.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1139300 plsX 1080370 plsX Shigella flexneri 2a str. 2457T glycerol-3-phosphate acyltransferase PlsX NP_836795.2 1138230 D 198215 CDS NP_836796.1 30062625 1077576 1139368..1140321 1 NC_004741.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1140321 fabH 1077576 fabH Shigella flexneri 2a str. 2457T 3-oxoacyl-ACP synthase NP_836796.1 1139368 D 198215 CDS NP_836797.1 30062626 1080752 1140337..1141266 1 NC_004741.1 residues 1 to 309 of 309 are 93.20 pct identical to residues 1 to 309 of 309 from Escherichia coli K-12 : B1092; acyl carrier protein S-malonyltransferase 1141266 fabD 1080752 fabD Shigella flexneri 2a str. 2457T acyl carrier protein S-malonyltransferase NP_836797.1 1140337 D 198215 CDS NP_836798.1 30062627 1077578 1141279..1142013 1 NC_004741.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1142013 fabG 1077578 fabG Shigella flexneri 2a str. 2457T 3-ketoacyl-ACP reductase NP_836798.1 1141279 D 198215 CDS NP_836799.1 30062628 1077579 1142224..1142460 1 NC_004741.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1142460 acpP 1077579 acpP Shigella flexneri 2a str. 2457T acyl carrier protein NP_836799.1 1142224 D 198215 CDS NP_836800.1 30062629 1078139 1142547..1143788 1 NC_004741.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 1143788 fabF 1078139 fabF Shigella flexneri 2a str. 2457T 3-oxoacyl-(acyl carrier protein) synthase II NP_836800.1 1142547 D 198215 CDS NP_836801.1 30062630 1077580 1143908..1144717 1 NC_004741.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1144717 pabC 1077580 pabC Shigella flexneri 2a str. 2457T 4-amino-4-deoxychorismate lyase NP_836801.1 1143908 D 198215 CDS NP_836802.1 30062631 1077581 1144720..1145742 1 NC_004741.1 residues 24 to 340 of 340 are 99.05 pct identical to residues 24 to 340 of 340 from Escherichia coli K-12 : B1097; hypothetical protein 1145742 yceG 1077581 yceG Shigella flexneri 2a str. 2457T hypothetical protein NP_836802.1 1144720 D 198215 CDS NP_836803.1 30062632 1077583 1145732..1146373 1 NC_004741.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1146373 tmk 1077583 tmk Shigella flexneri 2a str. 2457T thymidylate kinase NP_836803.1 1145732 D 198215 CDS NP_836804.1 30062633 1077375 1146370..1147374 1 NC_004741.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1147374 holB 1077375 holB Shigella flexneri 2a str. 2457T DNA polymerase III subunit delta' NP_836804.1 1146370 D 198215 CDS NP_836805.1 30062634 1077584 1147385..1148182 1 NC_004741.1 residues 1 to 265 of 265 are 93.58 pct identical to residues 1 to 265 of 265 from Escherichia coli K-12 : B1100; metallodependent hydrolase 1148182 ycfH 1077584 ycfH Shigella flexneri 2a str. 2457T metallodependent hydrolase NP_836805.1 1147385 D 198215 CDS NP_836806.1 30062635 1080692 1148477..1149910 1 NC_004741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; glucose-specific PTS system IIBC components 1149910 ptsG 1080692 ptsG Shigella flexneri 2a str. 2457T glucose-specific PTS system IIBC components NP_836806.1 1148477 D 198215 CDS NP_836807.1 30062636 1077589 1152494..1152853 1 NC_004741.1 residues 1 to 119 of 119 are 100.00 pct identical to residues 1 to 119 of 119 from Escherichia coli K-12 : B1103; purine nucleoside phosphoramidase 1152853 ycfF 1077589 ycfF Shigella flexneri 2a str. 2457T purine nucleoside phosphoramidase NP_836807.1 1152494 D 198215 CDS NP_836808.1 30062637 1078458 1152856..1153233 1 NC_004741.1 residues 1 to 125 of 125 are 90.39 pct identical to residues 1 to 125 of 125 from Escherichia coli K-12 : B1104; hypothetical protein 1153233 ycfL 1078458 ycfL Shigella flexneri 2a str. 2457T hypothetical protein NP_836808.1 1152856 D 198215 CDS NP_836809.1 30062638 1077590 1153248..1153889 1 NC_004741.1 residues 1 to 213 of 213 are 82.62 pct identical to residues 1 to 213 of 213 from Escherichia coli K-12 : B1105; hypothetical protein 1153889 ycfM 1077590 ycfM Shigella flexneri 2a str. 2457T hypothetical protein NP_836809.1 1153248 D 198215 CDS NP_836810.1 30062639 1077594 1153870..1154694 1 NC_004741.1 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1154694 thiK 1077594 thiK Shigella flexneri 2a str. 2457T thiamine kinase NP_836810.1 1153870 D 198215 CDS NP_836811.1 30062640 1077595 1154705..1155730 1 NC_004741.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1155730 ycfO 1077595 ycfO Shigella flexneri 2a str. 2457T beta-hexosaminidase NP_836811.1 1154705 D 198215 CDS NP_836812.1 30062641 1077610 1155753..1156295 1 NC_004741.1 residues 1 to 180 of 180 are 100.00 pct identical to residues 20 to 199 of 199 from Escherichia coli K-12 : B1108; hypothetical protein 1156295 ycfP 1077610 ycfP Shigella flexneri 2a str. 2457T hypothetical protein NP_836812.1 1155753 D 198215 CDS NP_836813.1 30062642 1077597 1156703..1158007 1 NC_004741.1 residues 1 to 434 of 434 are 96.54 pct identical to residues 1 to 434 of 434 from Escherichia coli K-12 : B1109; respiratory NADH dehydrogenase 1158007 ndh 1077597 ndh Shigella flexneri 2a str. 2457T respiratory NADH dehydrogenase NP_836813.1 1156703 D 198215 CDS NP_836814.1 30062643 1077599 1158234..1158773 1 NC_004741.1 residues 1 to 179 of 179 are 89.94 pct identical to residues 1 to 179 of 179 from Escherichia coli K-12 : B1110; hypothetical protein 1158773 ycfJ 1077599 ycfJ Shigella flexneri 2a str. 2457T hypothetical protein NP_836814.1 1158234 D 198215 CDS NP_836815.1 30062644 1076963 complement(1158835..1159545) 1 NC_004741.1 residues 1 to 236 of 236 are 99.57 pct identical to residues 1 to 236 of 236 from Escherichia coli K-12 : B1111; hypothetical protein 1159545 ycfQ 1076963 ycfQ Shigella flexneri 2a str. 2457T hypothetical protein NP_836815.1 1158835 R 198215 CDS NP_836816.1 30062645 1077600 1159752..1159964 1 NC_004741.1 residues 1 to 70 of 70 are 98.57 pct identical to residues 16 to 85 of 85 from Escherichia coli K-12 : B1112; hypothetical protein 1159964 ycfR 1077600 ycfR Shigella flexneri 2a str. 2457T hypothetical protein NP_836816.1 1159752 D 198215 CDS NP_836817.1 30062646 1080746 complement(1160047..1161009) 1 NC_004741.1 residues 1 to 320 of 320 are 93.12 pct identical to residues 1 to 320 of 320 from Escherichia coli K-12 : B1113; hypothetical protein 1161009 ycfS 1080746 ycfS Shigella flexneri 2a str. 2457T hypothetical protein NP_836817.1 1160047 R 198215 CDS NP_836818.1 30062647 1077601 complement(1161152..1164598) 1 NC_004741.1 residues 1 to 1148 of 1148 are 98.25 pct identical to residues 1 to 1148 of 1148 from Escherichia coli K-12 : B1114; mutation frequency decline; transcription-repair coupling factor 1164598 mfd 1077601 mfd Shigella flexneri 2a str. 2457T transcription-repair coupling factor NP_836818.1 1161152 R 198215 CDS NP_836819.1 30062648 1077604 complement(1164726..1165799) 1 NC_004741.1 residues 1 to 357 of 357 are 90.75 pct identical to residues 1 to 357 of 357 from Escherichia coli K-12 : B1115; hypothetical protein 1165799 ycfT 1077604 ycfT Shigella flexneri 2a str. 2457T hypothetical protein NP_836819.1 1164726 R 198215 CDS NP_836820.1 30062649 1077603 1166061..1167260 1 NC_004741.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1167260 ycfU 1077603 ycfU Shigella flexneri 2a str. 2457T outer membrane-specific lipoprotein transporter subunit LolC NP_836820.1 1166061 D 198215 CDS NP_836821.1 30062650 1077592 1167253..1167954 1 NC_004741.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1167954 lolD 1077592 lolD Shigella flexneri 2a str. 2457T lipoprotein transporter ATP-binding subunit NP_836821.1 1167253 D 198215 CDS NP_836822.1 30062651 1077606 1167954..1169198 1 NC_004741.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1169198 ycfW 1077606 ycfW Shigella flexneri 2a str. 2457T outer membrane-specific lipoprotein transporter subunit LolE NP_836822.1 1167954 D 198215 CDS NP_836823.1 30062652 1076442 1169227..1170138 1 NC_004741.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1170138 ycfX 1076442 ycfX Shigella flexneri 2a str. 2457T N-acetyl-D-glucosamine kinase NP_836823.1 1169227 D 198215 CDS NP_836824.1 30062653 1077607 1170154..1170975 1 NC_004741.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1170975 cobB 1077607 cobB Shigella flexneri 2a str. 2457T NAD-dependent deacetylase NP_836824.1 1170154 D 198215 CDS NP_836825.1 30062654 1080984 complement(1171131..1172177) 1 NC_004741.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter substrate-binding protein 1172177 potD 1080984 potD Shigella flexneri 2a str. 2457T spermidine/putrescine ABC transporter substrate-binding protein NP_836825.1 1171131 R 198215 CDS NP_836826.1 30062655 1077608 complement(1172174..1172968) 1 NC_004741.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter 1172968 potC 1077608 potC Shigella flexneri 2a str. 2457T spermidine/putrescine ABC transporter NP_836826.1 1172174 R 198215 CDS NP_836827.2 161486506 1077602 complement(1172965..1173822) 1 NC_004741.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter 1173822 potB 1077602 potB Shigella flexneri 2a str. 2457T spermidine/putrescine ABC transporter NP_836827.2 1172965 R 198215 CDS NP_836828.1 30062657 1077612 complement(1173806..1174942) 1 NC_004741.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 1174942 potA 1077612 potA Shigella flexneri 2a str. 2457T putrescine/spermidine ABC transporter ATPase NP_836828.1 1173806 R 198215 CDS NP_836829.1 30062658 1077613 1175192..1176418 1 NC_004741.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1176418 pepT 1077613 pepT Shigella flexneri 2a str. 2457T peptidase T NP_836829.1 1175192 D 198215 CDS NP_836830.1 30062659 1077598 complement(1176467..1177597) 1 NC_004741.1 residues 1 to 376 of 376 are 95.21 pct identical to residues 1 to 376 of 376 from Escherichia coli K-12 : B1128; hypothetical protein 1177597 ycfD 1077598 ycfD Shigella flexneri 2a str. 2457T hypothetical protein NP_836830.1 1176467 R 198215 CDS NP_836831.1 30062660 1077614 1177837..1179066 1 NC_004741.1 residues 1 to 409 of 409 are 100.00 pct identical to residues 8 to 416 of 416 from GenPept : >gb|AAG55933.1|AE005327_3 (AE005327) integrase of prophage CP-933C [Escherichia coli O157:H7 EDL933]; integrase of prophage CP-933C 1179066 1077614 S1211 Shigella flexneri 2a str. 2457T integrase of prophage CP-933C NP_836831.1 1177837 D 198215 CDS NP_836832.1 30062661 1078340 1180340..1180642 1 NC_004741.1 residues 35 to 99 of 100 are 95.38 pct identical to residues 1 to 65 of 65 from GenPept : >dbj|BAB35000.1| (AP002555) Icd-like protein [Escherichia coli O157:H7]; hypothetical protein 1180642 1078340 S1212 Shigella flexneri 2a str. 2457T hypothetical protein NP_836832.1 1180340 D 198215 CDS NP_836833.1 30062662 1077615 1181307..1181606 1 NC_004741.1 residues 1 to 99 of 99 are 87.87 pct identical to residues 1 to 99 of 99 from GenPept : >dbj|BAB35004.1| (AP002555) hypothetical protein [Escherichia coli O157:H7]; hypothetical protein 1181606 1077615 S1214 Shigella flexneri 2a str. 2457T hypothetical protein NP_836833.1 1181307 D 198215 CDS NP_836834.1 30062663 1077616 1181603..1183351 1 NC_004741.1 residues 142 to 559 of 582 are 49.28 pct identical to residues 309 to 725 of 763 from GenPept : >emb|CAC89726.1| (AJ414145) primase [Yersinia pestis]; bacteriophage P4 DNA primase 1183351 1077616 S1215 Shigella flexneri 2a str. 2457T bacteriophage P4 DNA primase NP_836834.1 1181603 D 198215 CDS NP_836835.1 30062664 1077617 1183718..1183918 1 NC_004741.1 residues 1 to 66 of 66 are 71.21 pct identical to residues 18 to 83 of 83 from GenPept : >gb|AAG55941.1|AE005327_11 (AE005327) unknown protein encoded by prophage CP-933C [Escherichia coli O157:H7 EDL933]; hypothetical protein 1183918 1077617 S1216 Shigella flexneri 2a str. 2457T hypothetical protein NP_836835.1 1183718 D 198215 CDS NP_836836.1 30062665 1077618 1183915..1184220 1 NC_004741.1 no significant similarities; hypothetical protein 1184220 1077618 S1217 Shigella flexneri 2a str. 2457T hypothetical protein NP_836836.1 1183915 D 198215 CDS NP_836837.1 30062666 1077619 1184230..1184391 1 NC_004741.1 no significant similarities; hypothetical protein 1184391 1077619 S1218 Shigella flexneri 2a str. 2457T hypothetical protein NP_836837.1 1184230 D 198215 CDS NP_836838.1 30062667 1077620 1184533..1184757 1 NC_004741.1 residues 1 to 74 of 74 are 94.59 pct identical to residues 27 to 100 of 100 from GenPept : >gb|AAG55943.1|AE005328_1 (AE005328) unknown protein encoded by prophage CP-933C [Escherichia coli O157:H7 EDL933]; hypothetical protein 1184757 1077620 S1219 Shigella flexneri 2a str. 2457T hypothetical protein NP_836838.1 1184533 D 198215 CDS NP_836839.1 30062668 1077622 1186255..1186827 1 NC_004741.1 residues 1 to 190 of 190 are 97.89 pct identical to residues 1 to 190 of 190 from GenPept : >gb|AAG55945.1|AE005328_3 (AE005328) head maturation protease of prophage CP-933C [Escherichia coli O157:H7 EDL933]; head maturation protease of prophage CP-933C 1186827 1077622 S1222 Shigella flexneri 2a str. 2457T head maturation protease of prophage CP-933C NP_836839.1 1186255 D 198215 CDS NP_836840.1 30062669 1077623 1186865..1187992 1 NC_004741.1 residues 1 to 375 of 375 are 97.60 pct identical to residues 13 to 387 of 403 from GenPept : >dbj|BAB35015.1| (AP002555) head portal protein [Escherichia coli O157:H7]; head portal protein 1187992 1077623 S1223 Shigella flexneri 2a str. 2457T head portal protein NP_836840.1 1186865 D 198215 CDS NP_836841.1 30062670 1077624 1188037..1188375 1 NC_004741.1 residues 1 to 112 of 112 are 96.42 pct identical to residues 1 to 112 of 112 from GenPept : >dbj|BAB35016.1| (AP002555) head-tail adaptor [Escherichia coli O157:H7]; head-tail adaptor 1188375 1077624 S1224 Shigella flexneri 2a str. 2457T head-tail adaptor NP_836841.1 1188037 D 198215 CDS NP_836842.1 30062671 1077956 1188372..1188668 1 NC_004741.1 residues 1 to 98 of 98 are 96.93 pct identical to residues 1 to 98 of 98 from GenPept : >gb|AAG55948.1|AE005328_6 (AE005328) unknown protein encoded by prophage CP-933C [Escherichia coli O157:H7 EDL933]; hypothetical protein 1188668 1077956 S1225 Shigella flexneri 2a str. 2457T hypothetical protein NP_836842.1 1188372 D 198215 CDS NP_836843.1 30062672 1077627 1188896..1189108 1 NC_004741.1 residues 1 to 70 of 70 are 71.42 pct identical to residues 60 to 129 of 129 from GenPept : >gb|AAG55949.1|AE005328_7 (AE005328) holin protein of prophage CP-933C [Escherichia coli O157:H7 EDL933]; holin protein of prophage CP-933C 1189108 1077627 S1226 Shigella flexneri 2a str. 2457T holin protein of prophage CP-933C NP_836843.1 1188896 D 198215 CDS NP_836844.1 30062673 1077628 1189345..1189656 1 NC_004741.1 residues 1 to 91 of 103 are 98.90 pct identical to residues 16 to 106 of 118 from GenPept : >gb|AAG55950.1|AE005328_8 (AE005328) unknown protein encoded by prophage CP-933C [Escherichia coli O157:H7 EDL933]; hypothetical protein 1189656 1077628 S1227 Shigella flexneri 2a str. 2457T hypothetical protein NP_836844.1 1189345 D 198215 CDS NP_836845.1 30062674 1077226 1189823..1191301 1 NC_004741.1 residues 1 to 492 of 492 are 91.46 pct identical to residues 18 to 509 of 509 from GenPept : >gb|AAG55951.1|AE005328_9 (AE005328) terminase of prophage CP-933C [Escherichia coli O157:H7 EDL933]; terminase of prophage CP-933C 1191301 1077226 S1228 Shigella flexneri 2a str. 2457T terminase of prophage CP-933C NP_836845.1 1189823 D 198215 CDS NP_836846.1 30062675 1077629 1191315..1191596 1 NC_004741.1 residues 1 to 93 of 93 are 93.54 pct identical to residues 1 to 93 of 93 from GenPept : >gb|AAG55952.1|AE005328_10 (AE005328) unknown protein encoded by prophage CP-933C [Escherichia coli O157:H7 EDL933]; hypothetical protein 1191596 1077629 S1229 Shigella flexneri 2a str. 2457T hypothetical protein NP_836846.1 1191315 D 198215 CDS NP_836847.1 30062676 1080919 complement(1192393..1193853) 1 NC_004741.1 residues 1 to 486 of 486 are 93.00 pct identical to residues 1 to 486 of 486 from Escherichia coli K-12 : B1129; sensor protein PhoQ 1193853 phoQ 1080919 phoQ Shigella flexneri 2a str. 2457T sensor protein PhoQ NP_836847.1 1192393 R 198215 CDS NP_836848.1 30062677 1077630 complement(1193853..1194524) 1 NC_004741.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 1194524 phoP 1077630 phoP Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator PhoP NP_836848.1 1193853 R 198215 CDS NP_836849.1 30062678 1077636 complement(1194693..1196063) 1 NC_004741.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1196063 purB 1077636 purB Shigella flexneri 2a str. 2457T adenylosuccinate lyase NP_836849.1 1194693 R 198215 CDS NP_836850.1 30062679 1077631 complement(1196067..1196708) 1 NC_004741.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1196708 ycfC 1077631 ycfC Shigella flexneri 2a str. 2457T hypothetical protein NP_836850.1 1196067 R 198215 CDS NP_836851.2 161486505 1077645 complement(1196744..1197850) 1 NC_004741.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1197850 mnmA 1077645 mnmA Shigella flexneri 2a str. 2457T tRNA-specific 2-thiouridylase MnmA NP_836851.2 1196744 R 198215 CDS NP_836852.1 30062681 1077632 complement(1197904..1198365) 1 NC_004741.1 residues 1 to 153 of 153 are 100.00 pct identical to residues 1 to 153 of 153 from Escherichia coli K-12 : B1134; phosphohydrolase 1198365 1077632 S1236 Shigella flexneri 2a str. 2457T phosphohydrolase NP_836852.1 1197904 R 198215 CDS NP_836853.1 30062682 1077658 complement(1198375..1198998) 1 NC_004741.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 1198998 ymfC 1077658 ymfC Shigella flexneri 2a str. 2457T 23S rRNA pseudouridine synthase E NP_836853.1 1198375 R 198215 CDS NP_836854.1 30062683 1077633 1199200..1200450 1 NC_004741.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1200450 icdA 1077633 icdA Shigella flexneri 2a str. 2457T isocitrate dehydrogenase NP_836854.1 1199200 D 198215 CDS NP_836855.1 30062684 1079276 complement(1200557..1201060) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS1 orfB 1201060 1079276 S1239 Shigella flexneri 2a str. 2457T IS1 orfB NP_836855.1 1200557 R 198215 CDS NP_836856.1 30062685 1077637 complement(1200979..1201254) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1201254 1077637 S1240 Shigella flexneri 2a str. 2457T IS1 orfA NP_836856.1 1200979 R 198215 CDS NP_836857.1 30062686 1079348 1201348..1202871 1 NC_004741.1 residues 1 to 507 of 507 are 98.61 pct identical to residues 1 to 507 of 507 from NRprotein_Feb2003 : >sp|P75995|YCGG_ECOLI Hypothetical protein ycgG; hypothetical protein 1202871 1079348 S1241 Shigella flexneri 2a str. 2457T hypothetical protein NP_836857.1 1201348 D 198215 CDS NP_836858.1 30062687 1077638 1203948..1206269 1 NC_004741.1 residues 431 to 749 of 773 are 96.86 pct identical to residues 5 to 323 of 338 from NRprotein_Feb2003 : >ref|NP_415688.1| part of ATP-binding component of a transport system [Escherichia coli K12] pir||G64862 hypothetical protein b1170 - Escherichia coli (strain K-12) gb|AAC74254.1| part of ATP-binding component of a transport system [Escherichia coli K12]; hypothetical protein 1206269 1077638 S1242 Shigella flexneri 2a str. 2457T hypothetical protein NP_836858.1 1203948 D 198215 CDS NP_836859.1 30062688 1080946 complement(1206326..1206661) 1 NC_004741.1 residues 1 to 111 of 111 are 100.00 pct identical to residues 1 to 111 of 111 from Escherichia coli K-12 : B1171; hypothetical protein 1206661 1080946 S1244 Shigella flexneri 2a str. 2457T hypothetical protein NP_836859.1 1206326 R 198215 CDS NP_836860.1 30062689 1077639 complement(1206665..1206949) 1 NC_004741.1 residues 1 to 94 of 94 are 35.10 pct identical to residues 1 to 94 of 94 from Escherichia coli K-12 : B1172; hypothetical protein 1206949 1077639 S1245 Shigella flexneri 2a str. 2457T hypothetical protein NP_836860.1 1206665 R 198215 CDS NP_836861.1 30062690 1080909 1207717..1207929 1 NC_004741.1 residues 1 to 70 of 70 are 94.28 pct identical to residues 1 to 70 of 70 from Escherichia coli K-12 : B1173; hypothetical protein 1207929 1080909 S1246 Shigella flexneri 2a str. 2457T hypothetical protein NP_836861.1 1207717 D 198215 CDS NP_836862.1 30062691 1077640 complement(1208301..1208567) 1 NC_004741.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1208567 minE 1077640 minE Shigella flexneri 2a str. 2457T cell division topological specificity factor MinE NP_836862.1 1208301 R 198215 CDS NP_836863.1 30062692 1077641 complement(1208571..1209383) 1 NC_004741.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1209383 minD 1077641 minD Shigella flexneri 2a str. 2457T cell division inhibitor MinD NP_836863.1 1208571 R 198215 CDS NP_836864.1 30062693 1077642 complement(1209407..1210102) 1 NC_004741.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 1210102 minC 1077642 minC Shigella flexneri 2a str. 2457T septum formation inhibitor NP_836864.1 1209407 R 198215 CDS NP_836865.2 161486504 1077644 complement(1210825..1211730) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1211730 1077644 S1251 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_836865.2 1210825 R 198215 CDS NP_836866.1 30062695 1077647 1212776..1213075 1 NC_004741.1 residues 1 to 99 of 99 are 100.00 pct identical to residues 1 to 99 of 99 from GenPept : >gb|AAL57580.1|AF453442_9 (AF453442) transposase 2 [Escherichia coli]; IS3 orfA 1213075 1077647 S1253 Shigella flexneri 2a str. 2457T IS3 orfA NP_836866.1 1212776 D 198215 CDS NP_836867.1 30062696 1077646 1213072..1213926 1 NC_004741.1 residues 1 to 284 of 284 are 100.00 pct identical to residues 1 to 284 of 288 from GenPept : >gb|AAL57581.1|AF453442_10 (AF453442) transposase 1 [Escherichia coli]; IS3 orfB 1213926 1077646 S1254 Shigella flexneri 2a str. 2457T IS3 orfB NP_836867.1 1213072 D 198215 CDS NP_836868.1 30062697 1077648 1214284..1214610 1 NC_004741.1 residues 1 to 108 of 108 are 98.14 pct identical to residues 1 to 108 of 108 from Escherichia coli K-12 : B1179; hypothetical protein 1214610 ycgL 1077648 ycgL Shigella flexneri 2a str. 2457T hypothetical protein NP_836868.1 1214284 D 198215 CDS NP_836869.1 30062698 1077418 1214682..1215341 1 NC_004741.1 residues 1 to 219 of 219 are 99.08 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B1180; hypothetical protein 1215341 1077418 S1257 Shigella flexneri 2a str. 2457T hypothetical protein NP_836869.1 1214682 D 198215 CDS NP_836870.2 161486503 1077650 1215433..1215879 1 NC_004741.1 residues 1 to 153 of 153 are 100.00 pct identical to residues 6 to 158 of 158 from Escherichia coli K-12 : B1181; hypothetical protein 1215879 ycgN 1077650 ycgN Shigella flexneri 2a str. 2457T hypothetical protein NP_836870.2 1215433 D 198215 CDS NP_836871.1 30062700 1077651 1217359..1217778 1 NC_004741.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1217778 umuD 1077651 umuD Shigella flexneri 2a str. 2457T DNA polymerase V subunit UmuD NP_836871.1 1217359 D 198215 CDS NP_836872.1 30062701 1080938 1217778..1219046 1 NC_004741.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1219046 umuC 1080938 umuC Shigella flexneri 2a str. 2457T DNA polymerase V subunit UmuC NP_836872.1 1217778 D 198215 CDS NP_836873.1 30062702 1077653 complement(1219092..1219622) 1 NC_004741.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1219622 dsbB 1077653 dsbB Shigella flexneri 2a str. 2457T disulfide bond formation protein B NP_836873.1 1219092 R 198215 CDS NP_836874.1 30062703 1079461 complement(1219768..1221309) 1 NC_004741.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1221309 nhaB 1079461 nhaB Shigella flexneri 2a str. 2457T sodium/proton antiporter NP_836874.1 1219768 R 198215 CDS NP_836875.1 30062704 1077654 1221530..1222249 1 NC_004741.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1222249 fadR 1077654 fadR Shigella flexneri 2a str. 2457T fatty acid metabolism regulator NP_836875.1 1221530 D 198215 CDS NP_836876.1 30062705 1077656 complement(1222301..1223833) 1 NC_004741.1 residues 1 to 510 of 510 are 99.60 pct identical to residues 1 to 510 of 510 from Escherichia coli K-12 : B1188; SpoVR family protein 1223833 ycgB 1077656 ycgB Shigella flexneri 2a str. 2457T SpoVR family protein NP_836876.1 1222301 R 198215 CDS NP_836877.1 30062706 1076627 1224163..1225461 1 NC_004741.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1225461 dadA 1076627 dadA Shigella flexneri 2a str. 2457T D-amino acid dehydrogenase small subunit NP_836877.1 1224163 D 198215 CDS NP_836878.1 30062707 1076629 1225471..1226541 1 NC_004741.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1226541 dadX 1076629 dadX Shigella flexneri 2a str. 2457T alanine racemase NP_836878.1 1225471 D 198215 CDS NP_836879.1 30062708 1077657 complement(1227396..1228004) 1 NC_004741.1 residues 116 to 190 of 202 are 42.66 pct identical to residues 42 to 114 of 565 from GenPept : >gb|AAL72346.1| (AF386526) IpaH7.8 [Shigella flexneri 2a]; invasion plasmid antigen fragment 1228004 ipaH_3 1077657 ipaH_3 Shigella flexneri 2a str. 2457T invasion plasmid antigen fragment NP_836879.1 1227396 R 198215 CDS NP_836880.2 161486502 1077669 complement(1228731..1230467) 1 NC_004741.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1230467 1077669 S1269 Shigella flexneri 2a str. 2457T potassium/proton antiporter NP_836880.2 1228731 R 198215 CDS NP_836881.1 30062710 1077659 complement(1230562..1231476) 1 NC_004741.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1231476 ldcA 1077659 ldcA Shigella flexneri 2a str. 2457T L,D-carboxypeptidase A NP_836881.1 1230562 R 198215 CDS NP_836882.1 30062711 1080910 1231462..1232187 1 NC_004741.1 residues 1 to 241 of 241 are 99.58 pct identical to residues 1 to 241 of 241 from Escherichia coli K-12 : B1193; murein transglycosylase E 1232187 mltE 1080910 mltE Shigella flexneri 2a str. 2457T murein transglycosylase E NP_836882.1 1231462 D 198215 CDS NP_836883.1 30062712 1077660 complement(1232189..1232923) 1 NC_004741.1 residues 1 to 244 of 244 are 99.18 pct identical to residues 1 to 244 of 244 from Escherichia coli K-12 : B1194; hypothetical protein 1232923 ycgR 1077660 ycgR Shigella flexneri 2a str. 2457T hypothetical protein NP_836883.1 1232189 R 198215 CDS NP_836884.1 30062713 1077696 1233124..1233378 1 NC_004741.1 residues 1 to 84 of 84 are 80.95 pct identical to residues 1 to 84 of 84 from Escherichia coli K-12 : B1195; hypothetical protein 1233378 ymgE 1077696 ymgE Shigella flexneri 2a str. 2457T hypothetical protein NP_836884.1 1233124 D 198215 CDS NP_836885.1 30062714 1077649 complement(1235408..1236262) 1 NC_004741.1 involved in molybdenum transport; molybdenum transport protein ModD 1236262 modD 1077649 modD Shigella flexneri 2a str. 2457T molybdenum transport protein ModD NP_836885.1 1235408 R 198215 CDS NP_836886.1 30062715 1077663 complement(1236262..1237071) 1 NC_004741.1 residues 1 to 269 of 269 are 94.79 pct identical to residues 1 to 269 of 270 from GenPept : >gb|AAC61711.1| (AF081283) Orf2 [Escherichia coli]; hypothetical protein 1237071 1077663 S1277 Shigella flexneri 2a str. 2457T hypothetical protein NP_836886.1 1236262 R 198215 CDS NP_836887.1 30062716 1079462 complement(1237081..1237839) 1 NC_004741.1 residues 1 to 251 of 252 are 98.40 pct identical to residues 1 to 251 of 252 from GenPept : >gb|AAG56052.1|AE005337_2 (AE005337) iron compound ABC transporter ATP-binding protein [Escherichia coli O157:H7 EDL933]; ferric enterobactin transport ATP-binding protein 1237839 1079462 S1278 Shigella flexneri 2a str. 2457T ferric enterobactin transport ATP-binding protein NP_836887.1 1237081 R 198215 CDS NP_836888.1 30062717 1077664 complement(1237836..1238816) 1 NC_004741.1 residues 1 to 314 of 326 are 87.89 pct identical to residues 1 to 314 of 326 from GenPept : >gb|AAG56053.1|AE005337_3 (AE005337) iron compound ABC transporter permease [Escherichia coli O157:H7 EDL933]; iron compound ABC transporter permease 1238816 1077664 S1279 Shigella flexneri 2a str. 2457T iron compound ABC transporter permease NP_836888.1 1237836 R 198215 CDS NP_836889.1 30062718 1077718 complement(1238816..1239838) 1 NC_004741.1 residues 1 to 340 of 340 are 87.05 pct identical to residues 1 to 340 of 340 from GenPept : >gb|AAG56054.1|AE005337_4 (AE005337) Z1966 gene product [Escherichia coli O157:H7 EDL933]; ABC transporter ATP-binding protein 1239838 1077718 S1280 Shigella flexneri 2a str. 2457T ABC transporter ATP-binding protein NP_836889.1 1238816 R 198215 CDS NP_836890.1 30062719 1078216 complement(1240551..1241054) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1241054 1078216 S1281 Shigella flexneri 2a str. 2457T IS1 orfB NP_836890.1 1240551 R 198215 CDS NP_836891.1 30062720 1077665 complement(1240973..1241248) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1241248 1077665 S1282 Shigella flexneri 2a str. 2457T IS1 orfA NP_836891.1 1240973 R 198215 CDS NP_836892.1 30062721 1077671 complement(1242200..1243897) 1 NC_004741.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase 1243897 treA 1077671 treA Shigella flexneri 2a str. 2457T trehalase NP_836892.1 1242200 R 198215 CDS NP_836893.1 30062722 1079261 complement(1244217..1245635) 1 NC_004741.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone; dihydroxyacetone kinase subunit M 1245635 ycgC 1079261 ycgC Shigella flexneri 2a str. 2457T dihydroxyacetone kinase subunit M NP_836893.1 1244217 R 198215 CDS NP_836894.1 30062723 1077672 complement(1245646..1246278) 1 NC_004741.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase ADP-binding subunit 1246278 1077672 S1286 Shigella flexneri 2a str. 2457T dihydroxyacetone kinase ADP-binding subunit NP_836894.1 1245646 R 198215 CDS NP_836895.1 30062724 1078397 complement(1246289..1247389) 1 NC_004741.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1247389 1078397 S1287 Shigella flexneri 2a str. 2457T dihydroxyacetone kinase subunit DhaK NP_836895.1 1246289 R 198215 CDS NP_836896.1 30062725 1077673 1247578..1249506 1 NC_004741.1 Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1249506 1077673 S1288 Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator DhaR NP_836896.1 1247578 D 198215 CDS NP_836897.1 30062726 1077662 complement(1249606..1252473) 1 NC_004741.1 residues 1 to 955 of 955 are 88.58 pct identical to residues 1 to 955 of 955 from Escherichia coli K-12 : B1202; adhesion and penetration protein 1252473 1077662 S1289 Shigella flexneri 2a str. 2457T adhesion and penetration protein NP_836897.1 1249606 R 198215 CDS NP_836898.1 30062727 1077675 complement(1253317..1254408) 1 NC_004741.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1254408 ychF 1077675 ychF Shigella flexneri 2a str. 2457T GTP-dependent nucleic acid-binding protein EngD NP_836898.1 1253317 R 198215 CDS NP_836899.1 30062728 1077683 complement(1254525..1255109) 1 NC_004741.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1255109 pth 1077683 pth Shigella flexneri 2a str. 2457T peptidyl-tRNA hydrolase NP_836899.1 1254525 R 198215 CDS NP_836900.1 30062729 1077670 1255387..1255665 1 NC_004741.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1255665 ychH 1077670 ychH Shigella flexneri 2a str. 2457T hypothetical protein NP_836900.1 1255387 D 198215 CDS NP_836901.1 30062730 1077676 complement(1255720..1257372) 1 NC_004741.1 role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM 1257372 ychM 1077676 ychM Shigella flexneri 2a str. 2457T sulfate transporter YchM NP_836901.1 1255720 R 198215 CDS NP_836902.1 30062731 1077605 complement(1257524..1258471) 1 NC_004741.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1258471 prsA 1077605 prsA Shigella flexneri 2a str. 2457T ribose-phosphate pyrophosphokinase NP_836902.1 1257524 R 198215 CDS NP_836903.1 30062732 1077678 complement(1258622..1259473) 1 NC_004741.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1259473 ipk 1077678 ipk Shigella flexneri 2a str. 2457T 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase NP_836903.1 1258622 R 198215 CDS NP_836904.1 30062733 1076727 complement(1259473..1260096) 1 NC_004741.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1260096 lolB 1076727 lolB Shigella flexneri 2a str. 2457T outer membrane lipoprotein LolB NP_836904.1 1259473 R 198215 CDS NP_836905.1 30062734 1077679 1260310..1261566 1 NC_004741.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1261566 hemA 1077679 hemA Shigella flexneri 2a str. 2457T glutamyl-tRNA reductase NP_836905.1 1260310 D 198215 CDS NP_836906.1 30062735 1079483 1261608..1262690 1 NC_004741.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1262690 prfA 1079483 prfA Shigella flexneri 2a str. 2457T peptide chain release factor 1 NP_836906.1 1261608 D 198215 CDS NP_836907.1 30062736 1077680 1262690..1263523 1 NC_004741.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1263523 hemK 1077680 hemK Shigella flexneri 2a str. 2457T N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase NP_836907.1 1262690 D 198215 CDS NP_836908.1 30062737 1077708 1263520..1263912 1 NC_004741.1 residues 1 to 130 of 130 are 99.23 pct identical to residues 1 to 130 of 130 from Escherichia coli K-12 : B1213; transcriptional regulator 1263912 1077708 S1300 Shigella flexneri 2a str. 2457T transcriptional regulator NP_836908.1 1263520 D 198215 CDS NP_836909.1 30062738 1077681 1263916..1264725 1 NC_004741.1 residues 1 to 269 of 269 are 92.93 pct identical to residues 1 to 269 of 269 from Escherichia coli K-12 : B1214; transcriptional regulator 1264725 ychA 1077681 ychA Shigella flexneri 2a str. 2457T transcriptional regulator NP_836909.1 1263916 D 198215 CDS NP_836910.1 30062739 1077667 1264761..1265615 1 NC_004741.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1265615 kdsA 1077667 kdsA Shigella flexneri 2a str. 2457T 2-dehydro-3-deoxyphosphooctonate aldolase NP_836910.1 1264761 D 198215 CDS NP_836911.1 30062740 1077684 complement(1266276..1267376) 1 NC_004741.1 residues 1 to 366 of 366 are 77.86 pct identical to residues 1 to 366 of 366 from Escherichia coli K-12 : B1216; calcium/sodium:proton antiporter 1267376 chaA 1077684 chaA Shigella flexneri 2a str. 2457T calcium/sodium:proton antiporter NP_836911.1 1266276 R 198215 CDS NP_836912.1 30062741 1080391 1267646..1267876 1 NC_004741.1 in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1267876 chaB 1080391 chaB Shigella flexneri 2a str. 2457T cation transport regulator NP_836912.1 1267646 D 198215 CDS NP_836913.1 30062742 1078215 1268013..1268729 1 NC_004741.1 residues 1 to 238 of 238 are 94.53 pct identical to residues 1 to 238 of 238 from Escherichia coli K-12 : B1218; cation transport regulator 1268729 chaC 1078215 chaC Shigella flexneri 2a str. 2457T cation transport regulator NP_836913.1 1268013 D 198215 CDS NP_836914.1 30062743 1077685 complement(1268773..1269126) 1 NC_004741.1 residues 1 to 117 of 117 are 100.00 pct identical to residues 1 to 117 of 117 from Escherichia coli K-12 : B1219; hypothetical protein 1269126 ychN 1077685 ychN Shigella flexneri 2a str. 2457T hypothetical protein NP_836914.1 1268773 R 198215 CDS NP_836915.1 30062744 1077677 1269452..1270705 1 NC_004741.1 residues 1 to 417 of 417 are 95.68 pct identical to residues 1 to 417 of 417 from Escherichia coli K-12 : B1220; hypothetical protein 1270705 ychP 1077677 ychP Shigella flexneri 2a str. 2457T hypothetical protein NP_836915.1 1269452 D 198215 CDS NP_836916.1 30062745 1077686 complement(1270706..1271356) 1 NC_004741.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1271356 narL 1077686 narL Shigella flexneri 2a str. 2457T transcriptional regulator NarL NP_836916.1 1270706 R 198215 CDS NP_836917.1 30062746 1077689 complement(1271349..1273145) 1 NC_004741.1 residues 1 to 598 of 598 are 98.32 pct identical to residues 1 to 598 of 598 from Escherichia coli K-12 : B1222; nitrate/nitrite sensor protein NarX 1273145 narX 1077689 narX Shigella flexneri 2a str. 2457T nitrate/nitrite sensor protein NarX NP_836917.1 1271349 R 198215 CDS NP_836918.1 30062747 1077701 1273484..1274875 1 NC_004741.1 residues 1 to 463 of 463 are 80.99 pct identical to residues 1 to 463 of 463 from Escherichia coli K-12 : B1223; nitrate transport protein nark 1274875 narK 1077701 narK Shigella flexneri 2a str. 2457T nitrate transport protein nark NP_836918.1 1273484 D 198215 CDS NP_836919.1 30062748 1077690 1275268..1279011 1 NC_004741.1 residues 1 to 1247 of 1247 are 99.83 pct identical to residues 1 to 1247 of 1247 from Escherichia coli K-12 : B1224; nitrate reductase 1 alpha subunit 1279011 narG 1077690 narG Shigella flexneri 2a str. 2457T nitrate reductase 1 alpha subunit NP_836919.1 1275268 D 198215 CDS NP_836920.1 30062749 1077691 1279008..1280546 1 NC_004741.1 residues 1 to 512 of 512 are 100.00 pct identical to residues 1 to 512 of 512 from Escherichia coli K-12 : B1225; nitrate reductase 1, beta subunit 1280546 narH 1077691 narH Shigella flexneri 2a str. 2457T nitrate reductase 1, beta subunit NP_836920.1 1279008 D 198215 CDS NP_836921.1 30062750 1076618 1280543..1281253 1 NC_004741.1 residues 1 to 236 of 236 are 97.88 pct identical to residues 1 to 236 of 236 from Escherichia coli K-12 : B1226; nitrate reductase 1, delta subunit 1281253 narJ 1076618 narJ Shigella flexneri 2a str. 2457T nitrate reductase 1, delta subunit NP_836921.1 1280543 D 198215 CDS NP_836922.1 30062751 1077693 1281253..1281930 1 NC_004741.1 residues 1 to 225 of 225 are 93.77 pct identical to residues 1 to 225 of 225 from Escherichia coli K-12 : B1227; nitrate reductase 1, cytochrome b(NR), gamma subunit 1281930 narI 1077693 narI Shigella flexneri 2a str. 2457T nitrate reductase 1, cytochrome b(NR), gamma subunit NP_836922.1 1281253 D 198215 CDS NP_836923.1 30062752 1079475 complement(1282714..1283556) 1 NC_004741.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1283556 purU 1079475 purU Shigella flexneri 2a str. 2457T formyltetrahydrofolate deformylase NP_836923.1 1282714 R 198215 CDS NP_836924.2 161486501 1077695 complement(1283606..1284064) 1 NC_004741.1 residues 1 to 104 of 119 are 99.03 pct identical to residues 34 to 137 of 152 from Escherichia coli K-12 : B1233; hypothetical protein 1284064 ychJ 1077695 ychJ Shigella flexneri 2a str. 2457T hypothetical protein NP_836924.2 1283606 R 198215 CDS NP_836925.1 30062754 1077687 1284177..1285082 1 NC_004741.1 residues 1 to 301 of 301 are 96.01 pct identical to residues 14 to 314 of 314 from Escherichia coli K-12 : B1234; hypothetical protein 1285082 ychK 1077687 ychK Shigella flexneri 2a str. 2457T hypothetical protein NP_836925.1 1284177 D 198215 CDS NP_836926.1 30062755 1077698 1285174..1286187 1 NC_004741.1 residues 1 to 337 of 337 are 92.28 pct identical to residues 1 to 337 of 337 from Escherichia coli K-12 : B1235; response regulator of RpoS 1286187 hnr 1077698 hnr Shigella flexneri 2a str. 2457T response regulator of RpoS NP_836926.1 1285174 D 198215 CDS NP_836927.1 30062756 1077674 1286389..1287297 1 NC_004741.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalU 1287297 galU 1077674 galU Shigella flexneri 2a str. 2457T UTP--glucose-1-phosphate uridylyltransferase subunit GalU NP_836927.1 1286389 D 198215 CDS NP_836928.1 30062757 1077699 complement(1287441..1287854) 1 NC_004741.1 residues 1 to 137 of 137 are 72.99 pct identical to residues 1 to 137 of 137 from Escherichia coli K-12 : B1237; global DNA-binding transcriptional dual regulator H-NS 1287854 hns 1077699 hns Shigella flexneri 2a str. 2457T global DNA-binding transcriptional dual regulator H-NS NP_836928.1 1287441 R 198215 CDS NP_836929.1 30062758 1077655 1288459..1289076 1 NC_004741.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1289076 tdk 1077655 tdk Shigella flexneri 2a str. 2457T thymidine kinase NP_836929.1 1288459 D 198215 CDS NP_836930.1 30062759 1077736 complement(1289362..1290690) 1 NC_004741.1 residues 1 to 442 of 442 are 99.32 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 1290690 1077736 S1325 Shigella flexneri 2a str. 2457T IS4 orf NP_836930.1 1289362 R 198215 CDS NP_836931.1 30062760 1077703 complement(1290816..1293491) 1 NC_004741.1 residues 1 to 872 of 891 are 91.74 pct identical to residues 1 to 872 of 891 from Escherichia coli K-12 : B1241; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1293491 adhE 1077703 adhE Shigella flexneri 2a str. 2457T bifunctional acetaldehyde-CoA/alcohol dehydrogenase NP_836931.1 1290816 R 198215 CDS NP_836932.1 30062761 1077995 1293968..1294615 1 NC_004741.1 residues 1 to 215 of 215 are 99.53 pct identical to residues 1 to 215 of 215 from Escherichia coli K-12 : B1242; hypothetical protein 1294615 ychE 1077995 ychE Shigella flexneri 2a str. 2457T hypothetical protein NP_836932.1 1293968 D 198215 CDS NP_836933.1 30062762 1077704 complement(1294982..1295485) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1295485 1077704 S1328 Shigella flexneri 2a str. 2457T IS1 orfB NP_836933.1 1294982 R 198215 CDS NP_836934.1 30062763 1077705 complement(1295404..1295679) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1295679 1077705 S1329 Shigella flexneri 2a str. 2457T IS1 orfA NP_836934.1 1295404 R 198215 CDS NP_836935.1 30062764 1077724 1296130..1297761 1 NC_004741.1 residues 1 to 543 of 543 are 95.76 pct identical to residues 1 to 543 of 543 from Escherichia coli K-12 : B1243; periplasmic oligopeptide binding protein 1297761 oppA 1077724 oppA Shigella flexneri 2a str. 2457T periplasmic oligopeptide binding protein NP_836935.1 1296130 D 198215 CDS NP_836936.1 30062765 1077706 1297847..1298767 1 NC_004741.1 residues 1 to 306 of 306 are 100.00 pct identical to residues 1 to 306 of 306 from Escherichia coli K-12 : B1244; oligopeptide transporter permease 1298767 oppB 1077706 oppB Shigella flexneri 2a str. 2457T oligopeptide transporter permease NP_836936.1 1297847 D 198215 CDS NP_836937.1 30062766 1080986 1298782..1299690 1 NC_004741.1 residues 1 to 302 of 302 are 81.45 pct identical to residues 1 to 302 of 302 from Escherichia coli K-12 : B1245; oligopeptide transport permease 1299690 oppC 1080986 oppC Shigella flexneri 2a str. 2457T oligopeptide transport permease NP_836937.1 1298782 D 198215 CDS NP_836938.1 30062767 1077707 1299702..1300715 1 NC_004741.1 residues 1 to 337 of 337 are 99.10 pct identical to residues 1 to 337 of 337 from Escherichia coli K-12 : B1246; oligopeptide transporter ATP-binding component 1300715 oppD 1077707 oppD Shigella flexneri 2a str. 2457T oligopeptide transporter ATP-binding component NP_836938.1 1299702 D 198215 CDS NP_836939.1 30062768 1077697 1300712..1301716 1 NC_004741.1 residues 1 to 334 of 334 are 97.90 pct identical to residues 1 to 334 of 334 from Escherichia coli K-12 : B1247; ATP-binding protein of oligopeptide ABC transport system 1301716 oppF 1077697 oppF Shigella flexneri 2a str. 2457T ATP-binding protein of oligopeptide ABC transport system NP_836939.1 1300712 D 198215 CDS NP_836940.2 161486500 1077710 complement(1301769..1302098) 1 NC_004741.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1302098 1077710 S1335 Shigella flexneri 2a str. 2457T dsDNA-mimic protein NP_836940.2 1301769 R 198215 CDS NP_836941.1 30062770 1077634 complement(1302133..1303593) 1 NC_004741.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1303593 cls 1077634 cls Shigella flexneri 2a str. 2457T cardiolipin synthetase NP_836941.1 1302133 R 198215 CDS NP_836942.1 30062771 1077711 complement(1303964..1305217) 1 NC_004741.1 residues 1 to 417 of 417 are 95.44 pct identical to residues 1 to 417 of 417 from Escherichia coli K-12 : B1250; voltage-gated potassium channel 1305217 kch 1077711 kch Shigella flexneri 2a str. 2457T voltage-gated potassium channel NP_836942.1 1303964 R 198215 CDS NP_836943.1 30062772 1077712 1305580..1305882 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 1305882 1077712 S1338 Shigella flexneri 2a str. 2457T IS600 orfA NP_836943.1 1305580 D 198215 CDS NP_836944.1 30062773 1077700 1306023..1306709 1 NC_004741.1 residues 1 to 228 of 228 are 86.49 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 1306709 1077700 S1339 Shigella flexneri 2a str. 2457T IS600 orfB NP_836944.1 1306023 D 198215 CDS NP_836945.2 161486499 1077720 complement(1306757..1307053) 1 NC_004741.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein 1307053 yciI 1077720 yciI Shigella flexneri 2a str. 2457T YciI-like protein NP_836945.2 1306757 R 198215 CDS NP_836946.1 30062775 1077715 1307268..1307996 1 NC_004741.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transporter 1307996 tonB 1077715 tonB Shigella flexneri 2a str. 2457T transporter NP_836946.1 1307268 D 198215 CDS NP_836947.1 30062776 1080851 complement(1308036..1308434) 1 NC_004741.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase 1308434 yciA 1080851 yciA Shigella flexneri 2a str. 2457T acyl-CoA thioester hydrolase NP_836947.1 1308036 R 198215 CDS NP_836948.1 30062777 1077719 complement(1308539..1309078) 1 NC_004741.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1309078 yciB 1077719 yciB Shigella flexneri 2a str. 2457T intracellular septation protein A NP_836948.1 1308539 R 198215 CDS NP_836949.1 30062778 1077713 complement(1309108..1309851) 1 NC_004741.1 residues 1 to 247 of 247 are 80.97 pct identical to residues 1 to 247 of 247 from Escherichia coli K-12 : B1255; hypothetical protein 1309851 yciC 1077713 yciC Shigella flexneri 2a str. 2457T hypothetical protein NP_836949.1 1309108 R 198215 CDS NP_836950.1 30062779 1077721 1310208..1310846 1 NC_004741.1 receptor for colicin S4; outer membrane protein W 1310846 yciD 1077721 yciD Shigella flexneri 2a str. 2457T outer membrane protein W NP_836950.1 1310208 D 198215 CDS NP_836951.1 30062780 1077722 complement(1310906..1311412) 1 NC_004741.1 residues 1 to 168 of 168 are 97.02 pct identical to residues 1 to 168 of 168 from Escherichia coli K-12 : B1257; hypothetical protein 1311412 yciE 1077722 yciE Shigella flexneri 2a str. 2457T hypothetical protein NP_836951.1 1310906 R 198215 CDS NP_836952.1 30062781 1077652 complement(1311458..1311958) 1 NC_004741.1 residues 1 to 166 of 166 are 81.92 pct identical to residues 1 to 166 of 166 from Escherichia coli K-12 : B1258; structural protein 1311958 yciF 1077652 yciF Shigella flexneri 2a str. 2457T structural protein NP_836952.1 1311458 R 198215 CDS NP_836953.1 30062782 1077723 complement(1312044..1312280) 1 NC_004741.1 residues 1 to 62 of 78 are 98.38 pct identical to residues 1 to 62 of 78 from Escherichia coli K-12 : B1259; hypothetical protein 1312280 yciG 1077723 yciG Shigella flexneri 2a str. 2457T hypothetical protein NP_836953.1 1312044 R 198215 CDS NP_836954.1 30062783 1080872 complement(1312603..1313409) 1 NC_004741.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1313409 trpA 1080872 trpA Shigella flexneri 2a str. 2457T tryptophan synthase subunit alpha NP_836954.1 1312603 R 198215 CDS NP_836955.1 30062784 1077725 complement(1313409..1314602) 1 NC_004741.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1314602 trpB 1077725 trpB Shigella flexneri 2a str. 2457T tryptophan synthase subunit beta NP_836955.1 1313409 R 198215 CDS NP_836956.1 30062785 1077749 complement(1314614..1315975) 1 NC_004741.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1315975 trpC 1077749 trpC Shigella flexneri 2a str. 2457T bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase NP_836956.1 1314614 R 198215 CDS NP_836957.1 30062786 1077728 complement(1315976..1317571) 1 NC_004741.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1317571 trpD 1077728 trpD Shigella flexneri 2a str. 2457T bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase NP_836957.1 1315976 R 198215 CDS NP_836958.1 30062787 1077739 complement(1317571..1319133) 1 NC_004741.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1319133 trpE 1077739 trpE Shigella flexneri 2a str. 2457T anthranilate synthase component I NP_836958.1 1317571 R 198215 CDS NP_836960.1 30062789 1077732 1319407..1320288 1 NC_004741.1 residues 1 to 293 of 293 are 94.53 pct identical to residues 1 to 293 of 293 from Escherichia coli K-12 : B1266; enzyme 1320288 yciV 1077732 yciV Shigella flexneri 2a str. 2457T enzyme NP_836960.1 1319407 D 198215 CDS NP_836961.1 30062790 1077734 1320249..1320905 1 NC_004741.1 residues 1 to 218 of 218 are 100.00 pct identical to residues 1 to 218 of 218 from Escherichia coli K-12 : B1267; hypothetical protein 1320905 yciO 1077734 yciO Shigella flexneri 2a str. 2457T hypothetical protein NP_836961.1 1320249 D 198215 CDS NP_836962.1 30062791 1077733 1321006..1321878 1 NC_004741.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1321878 yciL 1077733 yciL Shigella flexneri 2a str. 2457T 23S rRNA pseudouridylate synthase B NP_836962.1 1321006 D 198215 CDS NP_836963.1 30062792 1077716 complement(1321918..1322508) 1 NC_004741.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1322508 btuR 1077716 btuR Shigella flexneri 2a str. 2457T cob(I)yrinic acid a,c-diamide adenosyltransferase NP_836963.1 1321918 R 198215 CDS NP_836964.1 30062793 1077737 complement(1322505..1323263) 1 NC_004741.1 residues 1 to 252 of 252 are 99.20 pct identical to residues 1 to 252 of 252 from Escherichia coli K-12 : B1271; short chain dehydrogenase 1323263 yciK 1077737 yciK Shigella flexneri 2a str. 2457T short chain dehydrogenase NP_836964.1 1322505 R 198215 CDS NP_836965.1 30062794 1077726 1323483..1324532 1 NC_004741.1 SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1324532 sohB 1077726 sohB Shigella flexneri 2a str. 2457T periplasmic protease NP_836965.1 1323483 D 198215 CDS NP_836966.1 30062795 1077740 complement(1324568..1324819) 1 NC_004741.1 residues 1 to 83 of 83 are 100.00 pct identical to residues 1 to 83 of 83 from Escherichia coli K-12 : B1273; hypothetical protein 1324819 yciN 1077740 yciN Shigella flexneri 2a str. 2457T hypothetical protein NP_836966.1 1324568 R 198215 CDS NP_836967.1 30062796 1077741 1325199..1327796 1 NC_004741.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1327796 topA 1077741 topA Shigella flexneri 2a str. 2457T DNA topoisomerase I NP_836967.1 1325199 D 198215 CDS NP_836968.1 30062797 1077747 1328006..1328980 1 NC_004741.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1328980 cysB 1077747 cysB Shigella flexneri 2a str. 2457T transcriptional regulator CysB NP_836968.1 1328006 D 198215 CDS NP_836969.1 30062798 1077742 1329982..1332657 1 NC_004741.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1332657 acnA 1077742 acnA Shigella flexneri 2a str. 2457T aconitate hydratase NP_836969.1 1329982 D 198215 CDS NP_836970.1 30062799 1077746 complement(1332721..1333311) 1 NC_004741.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1333311 ribA 1077746 ribA Shigella flexneri 2a str. 2457T GTP cyclohydrolase II NP_836970.1 1332721 R 198215 CDS NP_836971.1 30062800 1077744 1333481..1334245 1 NC_004741.1 residues 1 to 254 of 254 are 94.09 pct identical to residues 1 to 254 of 254 from Escherichia coli K-12 : B1278; membrane bound; phosphatidylglycerophosphatase B 1334245 pgpB 1077744 pgpB Shigella flexneri 2a str. 2457T phosphatidylglycerophosphatase B NP_836971.1 1333481 D 198215 CDS NP_836972.1 30062801 1077717 1334394..1334702 1 NC_004741.1 residues 1 to 102 of 102 are 87.25 pct identical to residues 1 to 102 of 102 from Escherichia coli K-12 : B1279; hypothetical protein 1334702 yciS 1077717 yciS Shigella flexneri 2a str. 2457T hypothetical protein NP_836972.1 1334394 D 198215 CDS NP_836973.1 30062802 1077745 1334709..1335878 1 NC_004741.1 residues 10 to 389 of 389 are 99.73 pct identical to residues 10 to 389 of 389 from Escherichia coli K-12 : B1280; tetratricopeptide repeat protein 1335878 yciM 1077745 yciM Shigella flexneri 2a str. 2457T tetratricopeptide repeat protein NP_836973.1 1334709 D 198215 CDS NP_836974.1 30062803 1079523 1336071..1336808 1 NC_004741.1 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1336808 pyrF 1079523 pyrF Shigella flexneri 2a str. 2457T orotidine 5'-phosphate decarboxylase NP_836974.1 1336071 D 198215 CDS NP_836975.1 30062804 1077748 1336805..1337134 1 NC_004741.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1337134 yciH 1077748 yciH Shigella flexneri 2a str. 2457T translation initiation factor Sui1 NP_836975.1 1336805 D 198215 CDS NP_836976.1 30062805 1077727 complement(1337260..1337478) 1 NC_004741.1 residues 1 to 72 of 72 are 54.16 pct identical to residues 1 to 72 of 72 from Escherichia coli K-12 : B1283; lipoprotein 1337478 osmB 1077727 osmB Shigella flexneri 2a str. 2457T lipoprotein NP_836976.1 1337260 R 198215 CDS NP_836977.1 30062806 1077751 complement(1337747..1338496) 1 NC_004741.1 residues 1 to 249 of 249 are 99.59 pct identical to residues 1 to 249 of 249 from Escherichia coli K-12 : B1284; DEOR-type transcriptional regulator 1338496 1077751 S1371 Shigella flexneri 2a str. 2457T DEOR-type transcriptional regulator NP_836977.1 1337747 R 198215 CDS NP_836978.1 30062807 1077752 complement(1341116..1343050) 1 NC_004741.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1343050 rnb 1077752 rnb Shigella flexneri 2a str. 2457T exoribonuclease II NP_836978.1 1341116 R 198215 CDS NP_836979.1 30062808 1077731 complement(1343118..1344245) 1 NC_004741.1 residues 1 to 375 of 375 are 93.06 pct identical to residues 27 to 401 of 401 from Escherichia coli K-12 : B1287; oxidoreductase 1344245 yciW 1077731 yciW Shigella flexneri 2a str. 2457T oxidoreductase NP_836979.1 1343118 R 198215 CDS NP_836980.1 30062809 1077753 complement(1344389..1345177) 1 NC_004741.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 1345177 fabI 1077753 fabI Shigella flexneri 2a str. 2457T enoyl-(acyl carrier protein) reductase NP_836980.1 1344389 R 198215 CDS NP_836981.1 30062810 1077895 complement(1345545..1345898) 1 NC_004741.1 residues 1 to 117 of 117 are 95.72 pct identical to residues 1 to 117 of 117 from Escherichia coli K-12 : B1289; hypothetical protein 1345898 ycjD 1077895 ycjD Shigella flexneri 2a str. 2457T hypothetical protein NP_836981.1 1345545 R 198215 CDS NP_836982.1 30062811 1077755 complement(1345966..1346772) 1 NC_004741.1 residues 1 to 268 of 268 are 100.00 pct identical to residues 1 to 268 of 268 from Escherichia coli K-12 : B1290; ATP-binding protein of peptide transport system 1346772 sapF 1077755 sapF Shigella flexneri 2a str. 2457T ATP-binding protein of peptide transport system NP_836982.1 1345966 R 198215 CDS NP_836983.1 30062812 1077757 complement(1346774..1347766) 1 NC_004741.1 residues 1 to 330 of 330 are 100.00 pct identical to residues 1 to 330 of 330 from Escherichia coli K-12 : B1291; ATP-binding protein of peptide transport system 1347766 sapD 1077757 sapD Shigella flexneri 2a str. 2457T ATP-binding protein of peptide transport system NP_836983.1 1346774 R 198215 CDS NP_836984.1 30062813 1077743 complement(1347766..1348656) 1 NC_004741.1 residues 1 to 296 of 296 are 94.59 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 : B1292; peptide transport permease 1348656 sapC 1077743 sapC Shigella flexneri 2a str. 2457T peptide transport permease NP_836984.1 1347766 R 198215 CDS NP_836985.1 30062814 1080636 complement(1348643..1349608) 1 NC_004741.1 residues 23 to 321 of 321 are 93.31 pct identical to residues 23 to 321 of 321 from Escherichia coli K-12 : B1293; peptide transport permease 1349608 sapB 1080636 sapB Shigella flexneri 2a str. 2457T peptide transport permease NP_836985.1 1348643 R 198215 CDS NP_836986.1 30062815 1077759 complement(1349605..1351248) 1 NC_004741.1 residues 1 to 547 of 547 are 95.24 pct identical to residues 1 to 547 of 547 from Escherichia coli K-12 : B1294; peptide transport periplasmic protein 1351248 sapA 1077759 sapA Shigella flexneri 2a str. 2457T peptide transport periplasmic protein NP_836986.1 1349605 R 198215 CDS NP_836987.1 30062816 1077762 complement(1351939..1353324) 1 NC_004741.1 residues 1 to 461 of 461 are 99.78 pct identical to residues 19 to 479 of 479 from Escherichia coli K-12 : B1296; amino acid/amine transport protein 1353324 ycjJ 1077762 ycjJ Shigella flexneri 2a str. 2457T amino acid/amine transport protein NP_836987.1 1351939 R 198215 CDS NP_836988.1 30062817 1077761 complement(1353627..1355045) 1 NC_004741.1 residues 1 to 472 of 472 are 99.36 pct identical to residues 27 to 498 of 498 from Escherichia coli K-12 : B1297; glutamine synthetase 1355045 1077761 S1384 Shigella flexneri 2a str. 2457T glutamine synthetase NP_836988.1 1353627 R 198215 CDS NP_836989.1 30062818 1077782 1355245..1356021 1 NC_004741.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1356021 puuD 1077782 puuD Shigella flexneri 2a str. 2457T gamma-glutamyl-gamma-aminobutyrate hydrolase NP_836989.1 1355245 D 198215 CDS NP_836990.1 30062819 1077763 1356048..1356605 1 NC_004741.1 regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1356605 ycjC 1077763 ycjC Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor PuuR NP_836990.1 1356048 D 198215 CDS NP_836991.1 30062820 1077750 1356755..1358242 1 NC_004741.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1358242 aldH 1077750 aldH Shigella flexneri 2a str. 2457T gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase NP_836991.1 1356755 D 198215 CDS NP_836992.1 30062821 1077764 1358244..1359524 1 NC_004741.1 residues 1 to 426 of 426 are 96.00 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 : B1301; oxidoreductase 1359524 ordL 1077764 ordL Shigella flexneri 2a str. 2457T oxidoreductase NP_836992.1 1358244 D 198215 CDS NP_836993.1 30062822 1079511 1359562..1360827 1 NC_004741.1 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate transaminase 1360827 goaG 1079511 goaG Shigella flexneri 2a str. 2457T 4-aminobutyrate transaminase NP_836993.1 1359562 D 198215 CDS NP_836994.2 161486498 1077765 complement(1360947..1361924) 1 NC_004741.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 1361924 pspF 1077765 pspF Shigella flexneri 2a str. 2457T phage shock protein operon transcriptional activator NP_836994.2 1360947 R 198215 CDS NP_836995.1 30062824 1080731 1362091..1362759 1 NC_004741.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1362759 pspA 1080731 pspA Shigella flexneri 2a str. 2457T phage shock protein PspA NP_836995.1 1362091 D 198215 CDS NP_836996.1 30062825 1077768 1362813..1363037 1 NC_004741.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1363037 pspB 1077768 pspB Shigella flexneri 2a str. 2457T phage shock protein B NP_836996.1 1362813 D 198215 CDS NP_836997.1 30062826 1077771 1363037..1363396 1 NC_004741.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1363396 pspC 1077771 pspC Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator PspC NP_836997.1 1363037 D 198215 CDS NP_836998.1 30062827 1077770 1363405..1363626 1 NC_004741.1 residues 1 to 73 of 73 are 98.63 pct identical to residues 1 to 73 of 73 from Escherichia coli K-12 : B1307; peripheral inner membrane phage-shock protein 1363626 pspD 1077770 pspD Shigella flexneri 2a str. 2457T peripheral inner membrane phage-shock protein NP_836998.1 1363405 D 198215 CDS NP_836999.1 30062828 1078545 1363669..1364016 1 NC_004741.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1364016 pspE 1078545 pspE Shigella flexneri 2a str. 2457T thiosulfate:cyanide sulfurtransferase NP_836999.1 1363669 D 198215 CDS NP_837000.1 30062829 1077775 1365387..1365662 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1365662 1077775 S1397 Shigella flexneri 2a str. 2457T IS1 orfA NP_837000.1 1365387 D 198215 CDS NP_837001.1 30062830 1078548 1365581..1366084 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1366084 1078548 S1398 Shigella flexneri 2a str. 2457T IS1 orfB NP_837001.1 1365581 D 198215 CDS NP_837002.1 30062831 1077779 1368001..1368882 1 NC_004741.1 residues 1 to 293 of 293 are 88.73 pct identical to residues 1 to 293 of 293 from Escherichia coli K-12 : B1311; binding-protein dependent transport protein 1368882 ycjO 1077779 ycjO Shigella flexneri 2a str. 2457T binding-protein dependent transport protein NP_837002.1 1368001 D 198215 CDS NP_837003.1 30062832 1077780 1368869..1369711 1 NC_004741.1 residues 1 to 280 of 280 are 94.64 pct identical to residues 1 to 280 of 280 from Escherichia coli K-12 : B1312; transport system permease 1369711 ycjP 1077780 ycjP Shigella flexneri 2a str. 2457T transport system permease NP_837003.1 1368869 D 198215 CDS NP_837004.1 30062833 1077776 1369742..1370794 1 NC_004741.1 residues 1 to 350 of 350 are 96.28 pct identical to residues 1 to 350 of 350 from Escherichia coli K-12 : B1313; oxidoreductase 1370794 ycjQ 1077776 ycjQ Shigella flexneri 2a str. 2457T oxidoreductase NP_837004.1 1369742 D 198215 CDS NP_837005.1 30062834 1077082 1371597..1372652 1 NC_004741.1 residues 1 to 351 of 351 are 95.15 pct identical to residues 1 to 351 of 351 from Escherichia coli K-12 : B1315; dehydrogenase 1372652 ycjS 1077082 ycjS Shigella flexneri 2a str. 2457T dehydrogenase NP_837005.1 1371597 D 198215 CDS NP_837006.1 30062835 1077785 1372649..1374916 1 NC_004741.1 residues 1 to 755 of 755 are 96.55 pct identical to residues 1 to 755 of 755 from Escherichia coli K-12 : B1316; hypothetical protein 1374916 ycjT 1077785 ycjT Shigella flexneri 2a str. 2457T hypothetical protein NP_837006.1 1372649 D 198215 CDS NP_837007.1 30062836 1078550 1374913..1375572 1 NC_004741.1 residues 1 to 219 of 219 are 97.26 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B1317; beta-phosphoglucomutase 1375572 ycjU 1078550 ycjU Shigella flexneri 2a str. 2457T beta-phosphoglucomutase NP_837007.1 1374913 D 198215 CDS NP_837008.1 30062837 1077786 1375586..1376554 1 NC_004741.1 residues 1 to 322 of 322 are 95.34 pct identical to residues 1 to 322 of 322 from Escherichia coli K-12 : B1318; ATP-binding component of a transport system 1376554 ycjV 1077786 ycjV Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_837008.1 1375586 D 198215 CDS NP_837009.1 30062838 1080748 complement(1377723..1378721) 1 NC_004741.1 residues 1 to 332 of 332 are 95.48 pct identical to residues 1 to 332 of 332 from Escherichia coli K-12 : B1320; LACI-type transcriptional regulator 1378721 ycjW 1080748 ycjW Shigella flexneri 2a str. 2457T LACI-type transcriptional regulator NP_837009.1 1377723 R 198215 CDS NP_837010.1 30062839 1077788 1378877..1380274 1 NC_004741.1 residues 1 to 465 of 465 are 98.06 pct identical to residues 1 to 465 of 465 from Escherichia coli K-12 : B1321; enzyme 1380274 ycjX 1077788 ycjX Shigella flexneri 2a str. 2457T enzyme NP_837010.1 1378877 D 198215 CDS NP_837011.1 30062840 1078749 1380271..1381332 1 NC_004741.1 residues 1 to 353 of 353 are 90.65 pct identical to residues 1 to 353 of 353 from Escherichia coli K-12 : B1322; hypothetical protein 1381332 ycjF 1078749 ycjF Shigella flexneri 2a str. 2457T hypothetical protein NP_837011.1 1380271 D 198215 CDS NP_837012.1 30062841 1077789 1381480..1383021 1 NC_004741.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1383021 tyrR 1077789 tyrR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator TyrR NP_837012.1 1381480 D 198215 CDS NP_837013.1 30062842 1077790 complement(1383065..1383571) 1 NC_004741.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1383571 tpx 1077790 tpx Shigella flexneri 2a str. 2457T thiol peroxidase NP_837013.1 1383065 R 198215 CDS NP_837014.1 30062843 1077791 1383690..1384655 1 NC_004741.1 residues 1 to 321 of 321 are 92.21 pct identical to residues 15 to 335 of 335 from Escherichia coli K-12 : B1325; muconate cycloisomerase I 1384655 ycjG 1077791 ycjG Shigella flexneri 2a str. 2457T muconate cycloisomerase I NP_837014.1 1383690 D 198215 CDS NP_837015.1 30062844 1077792 complement(1384630..1385358) 1 NC_004741.1 residues 1 to 242 of 242 are 98.76 pct identical to residues 21 to 262 of 262 from Escherichia coli K-12 : B1326; murein peptide amidase A 1385358 ycjI 1077792 ycjI Shigella flexneri 2a str. 2457T murein peptide amidase A NP_837015.1 1384630 R 198215 CDS NP_837016.1 30062845 1077793 complement(1385649..1386287) 1 NC_004741.1 residues 1 to 212 of 212 are 99.05 pct identical to residues 5 to 216 of 216 from GenPept : >gb|AAG56475.1|AE005373_9 (AE005373) Z2446 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 1386287 1077793 S1416 Shigella flexneri 2a str. 2457T hypothetical protein NP_837016.1 1385649 R 198215 CDS NP_837017.1 30062846 1080439 1387115..1388200 1 NC_004741.1 residues 1 to 348 of 361 are 89.65 pct identical to residues 1 to 348 of 398 from GenPept : >gb|AAL72392.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl4 orf 1388200 1080439 S1418 Shigella flexneri 2a str. 2457T ISSfl4 orf NP_837017.1 1387115 D 198215 CDS NP_837018.1 30062847 1077795 1389744..1390226 1 NC_004741.1 residues 1 to 145 of 160 are 85.51 pct identical to residues 1 to 145 of 299 from Escherichia coli K-12 : B1328; LYSR-type transcriptional regulator 1390226 ycjZ 1077795 ycjZ Shigella flexneri 2a str. 2457T LYSR-type transcriptional regulator NP_837018.1 1389744 D 198215 CDS NP_837019.1 30062848 1077796 complement(1390223..1390936) 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 1390936 1077796 S1422 Shigella flexneri 2a str. 2457T IS600 orfB NP_837019.1 1390223 R 198215 CDS NP_837020.1 30062849 1077798 complement(1391077..1391379) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 1391379 1077798 S1423 Shigella flexneri 2a str. 2457T IS600 orfA NP_837020.1 1391077 R 198215 CDS NP_837021.1 30062850 1079542 1392226..1393860 1 NC_004741.1 residues 1 to 544 of 544 are 99.63 pct identical to residues 1 to 544 of 544 from Escherichia coli K-12 : B1329; transport periplasmic protein 1393860 1079542 S1424 Shigella flexneri 2a str. 2457T transport periplasmic protein NP_837021.1 1392226 D 198215 CDS NP_837022.1 30062851 1077799 complement(1393911..1394942) 1 NC_004741.1 residues 1 to 343 of 343 are 92.41 pct identical to residues 1 to 343 of 343 from Escherichia coli K-12 : B1330; hypothetical protein 1394942 1077799 S1425 Shigella flexneri 2a str. 2457T hypothetical protein NP_837022.1 1393911 R 198215 CDS NP_837023.1 30062852 1077800 1395070..1395372 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 1395372 1077800 S1426 Shigella flexneri 2a str. 2457T IS911 orfA NP_837023.1 1395070 D 198215 CDS NP_837024.1 30062853 1080952 complement(1395618..1396190) 1 NC_004741.1 residues 1 to 183 of 190 are 99.45 pct identical to residues 206 to 388 of 406 from GenPept : >gb|AAK85176.1| (AF294823) transposase [Shigella sonnei]; IS91 orf 1396190 1080952 S1427 Shigella flexneri 2a str. 2457T IS91 orf NP_837024.1 1395618 R 198215 CDS NP_837025.1 30062854 1077802 complement(1396190..1396804) 1 NC_004741.1 residues 1 to 199 of 204 are 98.49 pct identical to residues 1 to 199 of 426 from GenPept : >emb|CAA34970.1| (X17114) transposase IS91 [Escherichia coli]; IS91 orf 1396804 1077802 S1428 Shigella flexneri 2a str. 2457T IS91 orf NP_837025.1 1396190 R 198215 CDS NP_837026.1 30062855 1077966 complement(1396804..1397169) 1 NC_004741.1 residues 1 to 121 of 121 are 90.08 pct identical to residues 1 to 121 of 121 from GenPept : >gb|AAK85177.1| (AF294823) InsA [Shigella sonnei]; IS91 orf 1397169 1077966 S1429 Shigella flexneri 2a str. 2457T IS91 orf NP_837026.1 1396804 R 198215 CDS NP_837027.1 30062856 1077803 1397440..1397841 1 NC_004741.1 residues 1 to 124 of 133 are 100.00 pct identical to residues 72 to 195 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; IS911 orfB 1397841 1077803 S1431 Shigella flexneri 2a str. 2457T IS911 orfB NP_837027.1 1397440 D 198215 CDS NP_837028.1 30062857 1077805 complement(1398562..1399512) 1 NC_004741.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1399512 ydaA 1077805 ydaA Shigella flexneri 2a str. 2457T universal stress protein UspE NP_837028.1 1398562 R 198215 CDS NP_837029.1 30062858 1077807 complement(1399664..1400416) 1 NC_004741.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1400416 fnr 1077807 fnr Shigella flexneri 2a str. 2457T fumarate/nitrate reduction transcriptional regulator NP_837029.1 1399664 R 198215 CDS NP_837030.1 30062859 1076535 complement(1400611..1401126) 1 NC_004741.1 residues 1 to 171 of 171 are 91.81 pct identical to residues 1 to 171 of 171 from Escherichia coli K-12 : B1335; O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1401126 ogt 1076535 ogt Shigella flexneri 2a str. 2457T O-6-alkylguanine-DNA:cysteine-protein methyltransferase NP_837030.1 1400611 R 198215 CDS NP_837031.1 30062860 1078064 complement(1401670..1402056) 1 NC_004741.1 no significant similarities; hypothetical protein 1402056 1078064 S1430 Shigella flexneri 2a str. 2457T hypothetical protein NP_837031.1 1401670 R 198215 CDS NP_837032.1 30062861 1077811 1402582..1403229 1 NC_004741.1 residues 4 to 213 of 215 are 30.80 pct identical to residues 26 to 234 of 365 from GenPept : >emb|CAC49806.1| (AL603647) protein secretion protein, HlyD family, similar to E. coli EmrK [Sinorhizobium meliloti]; secretion protein 1403229 1077811 S1439 Shigella flexneri 2a str. 2457T secretion protein NP_837032.1 1402582 D 198215 CDS NP_837033.1 30062862 1077813 complement(1403393..1403659) 1 NC_004741.1 residues 1 to 88 of 88 are 100.00 pct identical to residues 1 to 88 of 88 from GenPept : >gb|AAL72506.1| (AF386526) transposase-like protein [Shigella flexneri 2a]; IS1294 transposase 1403659 1077813 S1440 Shigella flexneri 2a str. 2457T IS1294 transposase NP_837033.1 1403393 R 198215 CDS NP_837034.1 30062863 1077878 complement(1403767..1404591) 1 NC_004741.1 residues 1 to 274 of 274 are 99.27 pct identical to residues 1 to 274 of 399 from GenPept : >gb|AAL72439.1| (AF386526) transposase [Shigella flexneri 2a]; IS1294 transposase 1404591 1077878 S1441 Shigella flexneri 2a str. 2457T IS1294 transposase NP_837034.1 1403767 R 198215 CDS NP_837035.1 30062864 1077814 1404902..1405297 1 NC_004741.1 residues 2 to 129 of 131 are 56.25 pct identical to residues 236 to 363 of 367 from GenPept : >dbj|BAB49683.1| (AP003000) probable secretion protein [Mesorhizobium loti]; secretion protein 1405297 1077814 S1443 Shigella flexneri 2a str. 2457T secretion protein NP_837035.1 1404902 D 198215 CDS NP_837036.1 30062865 1077816 1409073..1410056 1 NC_004741.1 residues 1 to 327 of 327 are 93.27 pct identical to residues 1 to 327 of 327 from Escherichia coli K-12 : B1342; zinc transporter 1410056 zntB 1077816 zntB Shigella flexneri 2a str. 2457T zinc transporter NP_837036.1 1409073 D 198215 CDS NP_837037.1 30062866 1077817 1410534..1411901 1 NC_004741.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1411901 dbpA 1077817 dbpA Shigella flexneri 2a str. 2457T ATP-dependent RNA helicase DbpA NP_837037.1 1410534 D 198215 CDS NP_837038.1 30062867 1077818 complement(1412030..1412965) 1 NC_004741.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1412965 ydaO 1077818 ydaO Shigella flexneri 2a str. 2457T C32 tRNA thiolase NP_837038.1 1412030 R 198215 CDS NP_837039.1 30062868 1077819 complement(1413141..1413647) 1 NC_004741.1 residues 1 to 168 of 168 are 99.40 pct identical to residues 1 to 168 of 168 from Escherichia coli K-12 : B1376; filament protein 1413647 ynaF 1077819 ynaF Shigella flexneri 2a str. 2457T filament protein NP_837039.1 1413141 R 198215 CDS NP_837040.1 30062869 1077822 complement(1415212..1418736) 1 NC_004741.1 residues 1 to 1174 of 1174 are 99.14 pct identical to residues 1 to 1174 of 1174 from Escherichia coli K-12 : B1378; oxidoreductase, Fe-S subunit 1418736 ydbK 1077822 ydbK Shigella flexneri 2a str. 2457T oxidoreductase, Fe-S subunit NP_837040.1 1415212 R 198215 CDS NP_837041.1 30062870 1077824 complement(1419409..1419912) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1419912 1077824 S1453 Shigella flexneri 2a str. 2457T IS1 orfB NP_837041.1 1419409 R 198215 CDS NP_837042.1 30062871 1077826 complement(1419831..1420106) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1420106 1077826 S1454 Shigella flexneri 2a str. 2457T IS1 orfA NP_837042.1 1419831 R 198215 CDS NP_837043.1 30062872 1077827 complement(1420558..1420887) 1 NC_004741.1 residues 1 to 109 of 109 are 97.24 pct identical to residues 2 to 110 of 110 from Escherichia coli K-12 : B1383; hypothetical protein 1420887 ydbL 1077827 ydbL Shigella flexneri 2a str. 2457T hypothetical protein NP_837043.1 1420558 R 198215 CDS NP_837044.1 30062873 1077828 complement(1420892..1421077) 1 NC_004741.1 residues 1 to 61 of 61 are 100.00 pct identical to residues 1 to 61 of 61 from Escherichia coli K-12 : B1382; hypothetical protein 1421077 ynbE 1077828 ynbE Shigella flexneri 2a str. 2457T hypothetical protein NP_837044.1 1420892 R 198215 CDS NP_837045.1 30062874 1077831 complement(1421074..1423713) 1 NC_004741.1 residues 29 to 879 of 879 are 96.94 pct identical to residues 29 to 879 of 879 from Escherichia coli K-12 : B1381; hypothetical protein 1423713 ydbH 1077831 ydbH Shigella flexneri 2a str. 2457T hypothetical protein NP_837045.1 1421074 R 198215 CDS NP_837046.1 30062875 1077832 1423921..1424910 1 NC_004741.1 Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthes; D-lactate dehydrogenase 1424910 ldhA 1077832 ldhA Shigella flexneri 2a str. 2457T D-lactate dehydrogenase NP_837046.1 1423921 D 198215 CDS NP_837047.1 30062876 1077834 complement(1425347..1425850) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1425850 1077834 S1461 Shigella flexneri 2a str. 2457T IS1 orfB NP_837047.1 1425347 R 198215 CDS NP_837048.1 30062877 1077835 complement(1425769..1426044) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1426044 1077835 S1462 Shigella flexneri 2a str. 2457T IS1 orfA NP_837048.1 1425769 R 198215 CDS NP_837049.1 30062878 1077836 1426639..1428273 1 NC_004741.1 residues 1 to 544 of 544 are 98.16 pct identical to residues 227 to 770 of 770 from Escherichia coli K-12 : B1407; hypothetical protein 1428273 ydbD 1077836 ydbD Shigella flexneri 2a str. 2457T hypothetical protein NP_837049.1 1426639 D 198215 CDS NP_837050.1 30062879 1077837 1428444..1429049 1 NC_004741.1 residues 1 to 200 of 201 are 82.99 pct identical to residues 3 to 202 of 203 from Escherichia coli K-12 : B1408; hypothetical protein 1429049 1077837 S1464 Shigella flexneri 2a str. 2457T hypothetical protein NP_837050.1 1428444 D 198215 CDS NP_837051.1 30062880 1077838 1429201..1429944 1 NC_004741.1 residues 1 to 264 of 264 are 79.92 pct identical to residues 35 to 298 of 298 from Escherichia coli K-12 : B1409; phosphatidate cytidylyltransferase 1429944 1077838 S1465 Shigella flexneri 2a str. 2457T phosphatidate cytidylyltransferase NP_837051.1 1429201 D 198215 CDS NP_837052.1 30062881 1077839 1429960..1431717 1 NC_004741.1 residues 1 to 585 of 585 are 96.92 pct identical to residues 1 to 585 of 585 from Escherichia coli K-12 : B1410; hypothetical protein 1431717 1077839 S1466 Shigella flexneri 2a str. 2457T hypothetical protein NP_837052.1 1429960 D 198215 CDS NP_837053.1 30062882 1077841 complement(1432419..1433132) 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAB86997.1| (U97492) hypothetical 31 KD protein [Shigella flexneri]; IS600 orfB 1433132 1077841 S1468 Shigella flexneri 2a str. 2457T IS600 orfB NP_837053.1 1432419 R 198215 CDS NP_837054.1 30062883 1077842 complement(1433273..1433575) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 1433575 1077842 S1469 Shigella flexneri 2a str. 2457T IS600 orfA NP_837054.1 1433273 R 198215 CDS NP_837055.1 30062884 1077844 complement(1434338..1434943) 1 NC_004741.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1434943 acpD 1077844 acpD Shigella flexneri 2a str. 2457T azoreductase NP_837055.1 1434338 R 198215 CDS NP_837056.1 30062885 1080893 1435201..1439046 1 NC_004741.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1439046 hrpA 1080893 hrpA Shigella flexneri 2a str. 2457T ATP-dependent RNA helicase HrpA NP_837056.1 1435201 D 198215 CDS NP_837057.1 30062886 1077845 complement(1439247..1439960) 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 1439960 1077845 S1473 Shigella flexneri 2a str. 2457T IS600 orfB NP_837057.1 1439247 R 198215 CDS NP_837058.1 30062887 1077848 1441195..1442634 1 NC_004741.1 NAD-linked; aldehyde dehydrogenase A 1442634 aldA 1077848 aldA Shigella flexneri 2a str. 2457T aldehyde dehydrogenase A NP_837058.1 1441195 D 198215 CDS NP_837059.2 161486497 1077866 1443865..1444395 1 NC_004741.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1444395 cybB 1077866 cybB Shigella flexneri 2a str. 2457T cytochrome b561 NP_837059.2 1443865 D 198215 CDS NP_837060.1 30062889 1077850 1444640..1444813 1 NC_004741.1 residues 1 to 57 of 57 are 100.00 pct identical to residues 1 to 57 of 57 from Escherichia coli K-12 : B1419; hypothetical protein 1444813 ydcA 1077850 ydcA Shigella flexneri 2a str. 2457T hypothetical protein NP_837060.1 1444640 D 198215 CDS NP_837061.1 30062890 1077801 complement(1445135..1445986) 1 NC_004741.1 residues 1 to 283 of 283 are 98.93 pct identical to residues 1 to 283 of 283 from GenPept : >gb|AAC76582.1| (AE000433) IS150 transposase [Escherichia coli K12]; partial; IS103 orf 1445986 1077801 S1482 Shigella flexneri 2a str. 2457T IS103 orf NP_837061.1 1445135 R 198215 CDS NP_837062.1 30062891 1077858 complement(1445983..1446504) 1 NC_004741.1 residues 1 to 173 of 173 are 100.00 pct identical to residues 1 to 173 of 173 from GenPept : >gb|AAB18534.1| (U00039) orfA in IS150 [Escherichia coli]; partial; IS103 orf 1446504 1077858 S1483 Shigella flexneri 2a str. 2457T IS103 orf NP_837062.1 1445983 R 198215 CDS NP_837063.1 30062892 1077859 1446880..1448520 1 NC_004741.1 residues 1 to 546 of 546 are 87.72 pct identical to residues 1 to 546 of 546 from Escherichia coli K-12 : B1421; methyl-accepting chemotaxis protein III, ribose sensor receptor 1448520 trg 1077859 trg Shigella flexneri 2a str. 2457T methyl-accepting chemotaxis protein III, ribose sensor receptor NP_837063.1 1446880 D 198215 CDS NP_837064.1 30062893 1077862 complement(1448558..1449622) 1 NC_004741.1 residues 1 to 354 of 354 are 99.15 pct identical to residues 1 to 354 of 354 from Escherichia coli K-12 : B1422; LYSR-type transcriptional regulator 1449622 1077862 S1486 Shigella flexneri 2a str. 2457T LYSR-type transcriptional regulator NP_837064.1 1448558 R 198215 CDS NP_837065.1 30062894 1077855 1449698..1451041 1 NC_004741.1 residues 1 to 447 of 447 are 96.86 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 : B1423; hypothetical protein 1451041 1077855 S1487 Shigella flexneri 2a str. 2457T hypothetical protein NP_837065.1 1449698 D 198215 CDS NP_837066.1 30062895 1077864 1451266..1452921 1 NC_004741.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1452921 mdoD 1077864 mdoD Shigella flexneri 2a str. 2457T glucan biosynthesis protein D NP_837066.1 1451266 D 198215 CDS NP_837067.1 30062896 1077847 complement(1452842..1453045) 1 NC_004741.1 residues 1 to 67 of 67 are 98.50 pct identical to residues 1 to 67 of 67 from Escherichia coli K-12 : B1425; hypothetical protein 1453045 1077847 S1489 Shigella flexneri 2a str. 2457T hypothetical protein NP_837067.1 1452842 R 198215 CDS NP_837068.1 30062897 1077865 1453118..1453285 1 NC_004741.1 residues 1 to 55 of 55 are 100.00 pct identical to residues 1 to 55 of 55 from Escherichia coli K-12 : B1426; hypothetical protein 1453285 ydcH 1077865 ydcH Shigella flexneri 2a str. 2457T hypothetical protein NP_837068.1 1453118 D 198215 CDS NP_837069.1 30062898 1077880 1453348..1453884 1 NC_004741.1 residues 1 to 178 of 178 are 98.31 pct identical to residues 1 to 178 of 179 from Escherichia coli K-12 : B1427; involved in acetylation of N-terminal serine of 30S ribosomal subunit protein L7; ribosomal-protein-L7/L12-serine acetyltransferase 1453884 rimL 1077880 rimL Shigella flexneri 2a str. 2457T ribosomal-protein-L7/L12-serine acetyltransferase NP_837069.1 1453348 D 198215 CDS NP_837070.1 30062899 1077867 complement(1453879..1454859) 1 NC_004741.1 residues 1 to 326 of 326 are 98.46 pct identical to residues 1 to 326 of 326 from Escherichia coli K-12 : B1428; hypothetical protein 1454859 1077867 S1492 Shigella flexneri 2a str. 2457T hypothetical protein NP_837070.1 1453879 R 198215 CDS NP_837071.1 30062900 1077868 1454983..1455975 1 NC_004741.1 residues 1 to 330 of 330 are 94.24 pct identical to residues 1 to 330 of 330 from Escherichia coli K-12 : B1429; potassium-tellurite ethidium and proflavin transporter 1455975 tehA 1077868 tehA Shigella flexneri 2a str. 2457T potassium-tellurite ethidium and proflavin transporter NP_837071.1 1454983 D 198215 CDS NP_837072.1 30062901 1077871 1455972..1456565 1 NC_004741.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1456565 tehB 1077871 tehB Shigella flexneri 2a str. 2457T tellurite resistance protein TehB NP_837072.1 1455972 D 198215 CDS NP_837073.1 30062902 1077887 1456868..1457524 1 NC_004741.1 residues 1 to 218 of 218 are 91.44 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 : B1431; hypothetical protein 1457524 1077887 S1495 Shigella flexneri 2a str. 2457T hypothetical protein NP_837073.1 1456868 D 198215 CDS NP_837074.1 30062903 1079918 complement(1459137..1460324) 1 NC_004741.1 residues 1 to 388 of 395 are 97.93 pct identical to residues 1 to 388 of 426 from GenPept : >emb|CAA34970.1| (X17114) transposase IS91 [Escherichia coli]; partial; IS91 orf 1460324 1079918 S1497 Shigella flexneri 2a str. 2457T IS91 orf NP_837074.1 1459137 R 198215 CDS NP_837075.1 30062904 1077873 1460353..1460679 1 NC_004741.1 residues 1 to 67 of 108 are 98.50 pct identical to residues 1 to 67 of 79 from GenPept : >gb|AAC70084.1| (AF074613) unknown [Escherichia coli O157:H7]; partial; IS91 orf 1460679 1077873 S1498 Shigella flexneri 2a str. 2457T IS91 orf NP_837075.1 1460353 D 198215 CDS NP_837076.1 30062905 1077874 1461247..1461522 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1461522 1077874 S1499 Shigella flexneri 2a str. 2457T IS1 orfA NP_837076.1 1461247 D 198215 CDS NP_837077.1 30062906 1076486 1461441..1461944 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1461944 1076486 S1500 Shigella flexneri 2a str. 2457T IS1 orfB NP_837077.1 1461441 D 198215 CDS NP_837078.1 30062907 1077921 1462735..1463037 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 1463037 1077921 S1502 Shigella flexneri 2a str. 2457T IS600 orfA NP_837078.1 1462735 D 198215 CDS NP_837079.1 30062908 1077876 1463178..1463891 1 NC_004741.1 residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 1463891 1077876 S1503 Shigella flexneri 2a str. 2457T IS600 orfB NP_837079.1 1463178 D 198215 CDS NP_837080.1 30062909 1077877 complement(1464148..1464423) 1 NC_004741.1 residues 1 to 91 of 91 are 96.70 pct identical to residues 1 to 91 of 91 from Escherichia coli K-12 : B1837; hypothetical protein 1464423 1077877 S1504 Shigella flexneri 2a str. 2457T hypothetical protein NP_837080.1 1464148 R 198215 CDS NP_837081.1 30062910 1079524 complement(1464444..1464680) 1 NC_004741.1 residues 1 to 78 of 78 are 100.00 pct identical to residues 6 to 83 of 83 from Escherichia coli K-12 : B1836; hypothetical protein 1464680 1079524 S1505 Shigella flexneri 2a str. 2457T hypothetical protein NP_837081.1 1464444 R 198215 CDS NP_837082.1 30062911 1077881 complement(1468906..1470189) 1 NC_004741.1 residues 1 to 427 of 427 are 95.55 pct identical to residues 1 to 427 of 427 from Escherichia coli K-12 : B1833; hypothetical protein 1470189 1077881 S1508 Shigella flexneri 2a str. 2457T hypothetical protein NP_837082.1 1468906 R 198215 CDS NP_837083.1 30062912 1080914 1470319..1470816 1 NC_004741.1 residues 1 to 165 of 165 are 98.18 pct identical to residues 19 to 183 of 183 from Escherichia coli K-12 : B1832; hypothetical protein 1470816 1080914 S1509 Shigella flexneri 2a str. 2457T hypothetical protein NP_837083.1 1470319 D 198215 CDS NP_837084.1 30062913 1077883 1471492..1471611 1 NC_004741.1 residues 1 to 39 of 39 are 100.00 pct identical to residues 1 to 39 of 39 from Escherichia coli K-12 : B1831; hypothetical protein 1471611 yebJ 1077883 yebJ Shigella flexneri 2a str. 2457T hypothetical protein NP_837084.1 1471492 D 198215 CDS NP_837085.2 161486496 1077894 1471631..1473679 1 NC_004741.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1473679 prc 1077894 prc Shigella flexneri 2a str. 2457T carboxy-terminal protease NP_837085.2 1471631 D 198215 CDS NP_837086.1 30062915 1077884 1473874..1474752 1 NC_004741.1 metalloprotease; heat shock protein HtpX 1474752 htpX 1077884 htpX Shigella flexneri 2a str. 2457T heat shock protein HtpX NP_837086.1 1473874 D 198215 CDS NP_837087.1 30062916 1077885 complement(1474798..1476282) 1 NC_004741.1 residues 1 to 494 of 494 are 94.12 pct identical to residues 1 to 494 of 494 from Escherichia coli K-12 : B1828; transporter 1476282 1077885 S1513 Shigella flexneri 2a str. 2457T transporter NP_837087.1 1474798 R 198215 CDS NP_837088.1 30062917 1077870 1476348..1477139 1 NC_004741.1 residues 1 to 263 of 263 are 99.23 pct identical to residues 1 to 263 of 263 from Escherichia coli K-12 : B1827; regulator 1477139 1077870 S1514 Shigella flexneri 2a str. 2457T regulator NP_837088.1 1476348 D 198215 CDS NP_837089.1 30062918 1077886 1477680..1477823 1 NC_004741.1 residues 1 to 47 of 47 are 72.34 pct identical to residues 1 to 47 of 47 from Escherichia coli K-12 : B1826; hypothetical protein 1477823 1077886 S1515 Shigella flexneri 2a str. 2457T hypothetical protein NP_837089.1 1477680 D 198215 CDS NP_837090.1 30062919 1078656 1477898..1478185 1 NC_004741.1 residues 1 to 95 of 95 are 82.10 pct identical to residues 1 to 95 of 95 from Escherichia coli K-12 : B1825; hypothetical protein 1478185 1078656 S1516 Shigella flexneri 2a str. 2457T hypothetical protein NP_837090.1 1477898 D 198215 CDS NP_837091.1 30062920 1077890 1478855..1478998 1 NC_004741.1 residues 1 to 47 of 47 are 100.00 pct identical to residues 1 to 47 of 47 from Escherichia coli K-12 : B1824; hypothetical protein 1478998 1077890 S1517 Shigella flexneri 2a str. 2457T hypothetical protein NP_837091.1 1478855 D 198215 CDS NP_837092.1 30062921 1077891 1479011..1479220 1 NC_004741.1 residues 1 to 69 of 69 are 100.00 pct identical to residues 1 to 69 of 69 from Escherichia coli K-12 : B1823; cold shock-like protein CspC 1479220 cspC 1077891 cspC Shigella flexneri 2a str. 2457T cold shock-like protein CspC NP_837092.1 1479011 D 198215 CDS NP_837093.1 30062922 1076871 1479386..1480195 1 NC_004741.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase A 1480195 rrmA 1076871 rrmA Shigella flexneri 2a str. 2457T 23S rRNA methyltransferase A NP_837093.1 1479386 D 198215 CDS NP_837094.1 30062923 1077892 complement(1480192..1480812) 1 NC_004741.1 membrane protein YebN; hypothetical protein 1480812 1077892 S1520 Shigella flexneri 2a str. 2457T hypothetical protein NP_837094.1 1480192 R 198215 CDS NP_837095.1 30062924 1077893 complement(1481221..1481724) 1 NC_004741.1 residues 1 to 167 of 167 are 89.22 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1481724 1077893 S1521 Shigella flexneri 2a str. 2457T IS1 orfB NP_837095.1 1481221 R 198215 CDS NP_837096.1 30062925 1077889 complement(1481643..1481918) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1481918 1077889 S1522 Shigella flexneri 2a str. 2457T IS1 orfA NP_837096.1 1481643 R 198215 CDS NP_837097.1 30062926 1077896 complement(1481947..1482423) 1 NC_004741.1 residues 1 to 150 of 158 are 90.66 pct identical to residues 1 to 150 of 152 from Escherichia coli K-12 : B1820; hypothetical protein 1482423 1077896 S1523 Shigella flexneri 2a str. 2457T hypothetical protein NP_837097.1 1481947 R 198215 CDS NP_837098.1 30062927 1077853 complement(1482478..1483338) 1 NC_004741.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; mannose-specific PTS system protein IID 1483338 manZ 1077853 manZ Shigella flexneri 2a str. 2457T mannose-specific PTS system protein IID NP_837098.1 1482478 R 198215 CDS NP_837099.1 30062928 1077897 complement(1483342..1484142) 1 NC_004741.1 residues 1 to 266 of 266 are 94.36 pct identical to residues 1 to 266 of 266 from Escherichia coli K-12 : B1818; mannose-specific; PTS enzyme IIC 1484142 manY 1077897 manY Shigella flexneri 2a str. 2457T PTS enzyme IIC NP_837099.1 1483342 R 198215 CDS NP_837100.1 30062929 1077900 complement(1484205..1485176) 1 NC_004741.1 residues 1 to 323 of 323 are 91.02 pct identical to residues 1 to 323 of 323 from Escherichia coli K-12 : B1817; mannose-specific; PTS enzyme IIAB 1485176 manX 1077900 manX Shigella flexneri 2a str. 2457T PTS enzyme IIAB NP_837100.1 1484205 R 198215 CDS NP_837101.1 30062930 1077901 1485639..1487189 1 NC_004741.1 residues 1 to 516 of 516 are 91.69 pct identical to residues 1 to 518 of 518 from Escherichia coli K-12 : B1816; transporter 1487189 yoaE 1077901 yoaE Shigella flexneri 2a str. 2457T transporter NP_837101.1 1485639 D 198215 CDS NP_837102.1 30062931 1077925 complement(1487193..1488791) 1 NC_004741.1 residues 1 to 532 of 532 are 96.05 pct identical to residues 11 to 542 of 542 from Escherichia coli K-12 : B1815; hypothetical protein 1488791 1077925 S1528 Shigella flexneri 2a str. 2457T hypothetical protein NP_837102.1 1487193 R 198215 CDS NP_837103.1 30062932 1077902 complement(1488922..1490286) 1 NC_004741.1 residues 1 to 454 of 454 are 97.35 pct identical to residues 1 to 454 of 454 from Escherichia coli K-12 : B1814; L-serine deaminase 1490286 sdaA 1077902 sdaA Shigella flexneri 2a str. 2457T L-serine deaminase NP_837103.1 1488922 R 198215 CDS NP_837104.1 30062933 1077903 complement(1490470..1491048) 1 NC_004741.1 residues 1 to 192 of 192 are 92.18 pct identical to residues 1 to 192 of 192 from Escherichia coli K-12 : B1813; hypothetical protein 1491048 yeaB 1077903 yeaB Shigella flexneri 2a str. 2457T hypothetical protein NP_837104.1 1490470 R 198215 CDS NP_837105.1 30062934 1078761 complement(1491052..1492413) 1 NC_004741.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; para-aminobenzoate synthase component I 1492413 pabB 1078761 pabB Shigella flexneri 2a str. 2457T para-aminobenzoate synthase component I NP_837105.1 1491052 R 198215 CDS NP_837106.1 30062935 1077907 1492487..1492666 1 NC_004741.1 residues 1 to 59 of 59 are 96.61 pct identical to residues 1 to 59 of 59 from Escherichia coli K-12 : B1811; hypothetical protein 1492666 1077907 S1532 Shigella flexneri 2a str. 2457T hypothetical protein NP_837106.1 1492487 D 198215 CDS NP_837107.1 30062936 1076957 complement(1492786..1493145) 1 NC_004741.1 residues 1 to 119 of 119 are 100.00 pct identical to residues 1 to 119 of 119 from Escherichia coli K-12 : B1810; hypothetical protein 1493145 1076957 S1533 Shigella flexneri 2a str. 2457T hypothetical protein NP_837107.1 1492786 R 198215 CDS NP_837108.1 30062937 1077908 complement(1493507..1493899) 1 NC_004741.1 residues 1 to 130 of 130 are 100.00 pct identical to residues 1 to 130 of 130 from Escherichia coli K-12 : B1809; hypothetical protein 1493899 1077908 S1534 Shigella flexneri 2a str. 2457T hypothetical protein NP_837108.1 1493507 R 198215 CDS NP_837109.1 30062938 1077909 1493983..1495893 1 NC_004741.1 residues 1 to 636 of 636 are 99.68 pct identical to residues 1 to 636 of 636 from Escherichia coli K-12 : B1808; enzyme 1495893 1077909 S1535 Shigella flexneri 2a str. 2457T enzyme NP_837109.1 1493983 D 198215 CDS NP_837110.1 30062939 1077979 1495951..1496646 1 NC_004741.1 residues 1 to 231 of 231 are 92.64 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 : B1807; hypothetical protein 1496646 yeaZ 1077979 yeaZ Shigella flexneri 2a str. 2457T hypothetical protein NP_837110.1 1495951 D 198215 CDS NP_837111.1 30062940 1077910 1496686..1497267 1 NC_004741.1 residues 1 to 193 of 193 are 87.56 pct identical to residues 1 to 193 of 193 from Escherichia coli K-12 : B1806; outer membrane protein 1497267 1077910 S1537 Shigella flexneri 2a str. 2457T outer membrane protein NP_837111.1 1496686 D 198215 CDS NP_837112.1 30062941 1077911 1497407..1499158 1 NC_004741.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1499158 fadD 1077911 fadD Shigella flexneri 2a str. 2457T long-chain-fatty-acid--CoA ligase NP_837112.1 1497407 D 198215 CDS NP_837113.1 30062942 1077692 1499240..1500355 1 NC_004741.1 residues 1 to 371 of 371 are 95.68 pct identical to residues 5 to 375 of 375 from Escherichia coli K-12 : B1804; processes tRNA precursor; ribonuclease D 1500355 rnd 1077692 rnd Shigella flexneri 2a str. 2457T ribonuclease D NP_837113.1 1499240 D 198215 CDS NP_837114.1 30062943 1077913 complement(1500409..1501374) 1 NC_004741.1 residues 1 to 321 of 321 are 98.13 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B1803; diogenase beta subunit 1501374 yeaX 1077913 yeaX Shigella flexneri 2a str. 2457T diogenase beta subunit NP_837114.1 1500409 R 198215 CDS NP_837115.1 30062944 1077934 complement(1502389..1502955) 1 NC_004741.1 residues 80 to 188 of 188 are 48.62 pct identical to residues 68 to 174 of 174 from GenPept : >gb|AAF01132.1|AF083977_53 (AF083977) c-repressor [Enterobacteria phage Mu]; repressor protein 1502955 1077934 S1542 Shigella flexneri 2a str. 2457T repressor protein NP_837115.1 1502389 R 198215 CDS NP_837116.1 30062945 1077915 1503322..1503624 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 1503624 1077915 S1543 Shigella flexneri 2a str. 2457T IS600 orfA NP_837116.1 1503322 D 198215 CDS NP_837117.1 30062946 1077905 1503765..1504478 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 1504478 1077905 S1544 Shigella flexneri 2a str. 2457T IS600 orfB NP_837117.1 1503765 D 198215 CDS NP_837118.1 30062947 1077918 complement(1505400..1506425) 1 NC_004741.1 residues 1 to 341 of 341 are 98.82 pct identical to residues 44 to 384 of 384 from Escherichia coli K-12 : B1794; hypothetical protein 1506425 yeaP 1077918 yeaP Shigella flexneri 2a str. 2457T hypothetical protein NP_837118.1 1505400 R 198215 CDS NP_837119.1 30062948 1080908 1506608..1506862 1 NC_004741.1 residues 1 to 84 of 84 are 100.00 pct identical to residues 1 to 84 of 84 from Escherichia coli K-12 : B1793; hypothetical protein 1506862 yoaF 1080908 yoaF Shigella flexneri 2a str. 2457T hypothetical protein NP_837119.1 1506608 D 198215 CDS NP_837120.1 30062949 1077919 complement(1506884..1507252) 1 NC_004741.1 residues 1 to 122 of 122 are 96.72 pct identical to residues 1 to 122 of 122 from Escherichia coli K-12 : B1792; hypothetical protein 1507252 yeaO 1077919 yeaO Shigella flexneri 2a str. 2457T hypothetical protein NP_837120.1 1506884 R 198215 CDS NP_837121.1 30062950 1077854 complement(1507405..1508466) 1 NC_004741.1 residues 1 to 326 of 353 are 89.26 pct identical to residues 1 to 326 of 393 from Escherichia coli K-12 : B1791; amino acid/amine transport protein 1508466 yeaN 1077854 yeaN Shigella flexneri 2a str. 2457T amino acid/amine transport protein NP_837121.1 1507405 R 198215 CDS NP_837122.1 30062951 1077857 complement(1509337..1509783) 1 NC_004741.1 residues 1 to 148 of 148 are 74.32 pct identical to residues 1 to 148 of 148 from Escherichia coli K-12 : B1789; hypothetical protein 1509783 yeaL 1077857 yeaL Shigella flexneri 2a str. 2457T hypothetical protein NP_837122.1 1509337 R 198215 CDS NP_837123.1 30062952 1077923 1509905..1510057 1 NC_004741.1 residues 1 to 50 of 50 are 80.00 pct identical to residues 1 to 50 of 50 from Escherichia coli K-12 : B1788; hypothetical protein 1510057 1077923 S1551 Shigella flexneri 2a str. 2457T hypothetical protein NP_837123.1 1509905 D 198215 CDS NP_837124.1 30062953 1080727 complement(1510058..1510561) 1 NC_004741.1 residues 1 to 167 of 167 are 88.62 pct identical to residues 1 to 167 of 167 from Escherichia coli K-12 : B1787; hypothetical protein 1510561 yeaK 1080727 yeaK Shigella flexneri 2a str. 2457T hypothetical protein NP_837124.1 1510058 R 198215 CDS NP_837125.1 30062954 1077825 1512189..1512902 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 1512902 1077825 S1554 Shigella flexneri 2a str. 2457T IS600 orfB NP_837125.1 1512189 D 198215 CDS NP_837126.1 30062955 1077924 complement(1512927..1514306) 1 NC_004741.1 residues 1 to 455 of 459 are 99.56 pct identical to residues 1 to 455 of 644 from Escherichia coli K-12 : B1783; hypothetical protein 1514306 yeaG 1077924 yeaG Shigella flexneri 2a str. 2457T hypothetical protein NP_837126.1 1512927 R 198215 CDS NP_837127.1 30062956 1080449 1514742..1515488 1 NC_004741.1 residues 1 to 248 of 248 are 100.00 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 : B1782; hypothetical protein 1515488 yeaF 1080449 yeaF Shigella flexneri 2a str. 2457T hypothetical protein NP_837127.1 1514742 D 198215 CDS NP_837128.1 30062957 1077926 1515578..1516339 1 NC_004741.1 residues 1 to 253 of 253 are 83.09 pct identical to residues 1 to 284 of 284 from Escherichia coli K-12 : B1781; aldehyde reductase 1516339 1077926 S1557 Shigella flexneri 2a str. 2457T aldehyde reductase NP_837128.1 1515578 D 198215 CDS NP_837129.1 30062958 1077927 complement(1516390..1517274) 1 NC_004741.1 residues 1 to 294 of 294 are 99.31 pct identical to residues 8 to 301 of 301 from Escherichia coli K-12 : B1780; hypothetical protein 1517274 yeaD 1077927 yeaD Shigella flexneri 2a str. 2457T hypothetical protein NP_837129.1 1516390 R 198215 CDS NP_837130.1 30062959 1077928 complement(1517358..1518353) 1 NC_004741.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 1518353 gapA 1077928 gapA Shigella flexneri 2a str. 2457T glyceraldehyde-3-phosphate dehydrogenase NP_837130.1 1517358 R 198215 CDS NP_837131.1 30062960 1080943 1518695..1519108 1 NC_004741.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1519108 yeaA 1080943 yeaA Shigella flexneri 2a str. 2457T methionine sulfoxide reductase B NP_837131.1 1518695 D 198215 CDS NP_837132.1 30062961 1077930 1519150..1519422 1 NC_004741.1 residues 1 to 90 of 90 are 97.77 pct identical to residues 16 to 105 of 105 from Escherichia coli K-12 : B1777; hypothetical protein 1519422 1077930 S1561 Shigella flexneri 2a str. 2457T hypothetical protein NP_837132.1 1519150 D 198215 CDS NP_837133.1 30062962 1077952 1519792..1520868 1 NC_004741.1 residues 1 to 358 of 358 are 99.16 pct identical to residues 1 to 358 of 358 from Escherichia coli K-12 : B1776; oxidoreductase 1520868 1077952 S1562 Shigella flexneri 2a str. 2457T oxidoreductase NP_837133.1 1519792 D 198215 CDS NP_837134.1 30062963 1077933 1520895..1522274 1 NC_004741.1 residues 1 to 459 of 459 are 90.63 pct identical to residues 1 to 459 of 459 from Escherichia coli K-12 : B1775; transporter 1522274 1077933 S1563 Shigella flexneri 2a str. 2457T transporter NP_837134.1 1520895 D 198215 CDS NP_837135.1 30062964 1077935 1523357..1524193 1 NC_004741.1 residues 1 to 278 of 278 are 98.20 pct identical to residues 1 to 278 of 278 from Escherichia coli K-12 : B1773; aldolase 1524193 1077935 S1565 Shigella flexneri 2a str. 2457T aldolase NP_837135.1 1523357 D 198215 CDS NP_837136.1 30062965 1077943 1524198..1525145 1 NC_004741.1 residues 1 to 315 of 315 are 98.73 pct identical to residues 8 to 322 of 322 from Escherichia coli K-12 : B1772; kinase 1525145 1077943 S1566 Shigella flexneri 2a str. 2457T kinase NP_837136.1 1524198 D 198215 CDS NP_837137.1 30062966 1077936 1525200..1526135 1 NC_004741.1 residues 1 to 311 of 311 are 99.03 pct identical to residues 16 to 326 of 326 from Escherichia coli K-12 : B1771; hypothetical protein 1526135 1077936 S1567 Shigella flexneri 2a str. 2457T hypothetical protein NP_837137.1 1525200 D 198215 CDS NP_837138.1 30062967 1077937 1526272..1527030 1 NC_004741.1 residues 1 to 252 of 252 are 98.41 pct identical to residues 1 to 252 of 252 from Escherichia coli K-12 : B1770; DEOR-type transcriptional regulator 1527030 1077937 S1568 Shigella flexneri 2a str. 2457T DEOR-type transcriptional regulator NP_837138.1 1526272 D 198215 CDS NP_837139.1 30062968 1078013 1527148..1528506 1 NC_004741.1 residues 1 to 452 of 452 are 95.79 pct identical to residues 1 to 452 of 452 from Escherichia coli K-12 : B1769; transporter 1528506 ydjE 1078013 ydjE Shigella flexneri 2a str. 2457T transporter NP_837139.1 1527148 D 198215 CDS NP_837140.2 161486495 1077939 complement(1528599..1529240) 1 NC_004741.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1529240 ydjB 1077939 ydjB Shigella flexneri 2a str. 2457T nicotinamidase/pyrazinamidase NP_837140.2 1528599 R 198215 CDS NP_837141.1 30062970 1077946 complement(1529251..1530267) 1 NC_004741.1 converts asparagine to aspartate and ammonia; asparaginase 1530267 ansA 1077946 ansA Shigella flexneri 2a str. 2457T asparaginase NP_837141.1 1529251 R 198215 CDS NP_837142.1 30062971 1078030 complement(1530434..1532290) 1 NC_004741.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1532290 sppA 1078030 sppA Shigella flexneri 2a str. 2457T protease 4 NP_837142.1 1530434 R 198215 CDS NP_837143.1 30062972 1077947 1532451..1533002 1 NC_004741.1 residues 1 to 183 of 183 are 92.34 pct identical to residues 1 to 183 of 183 from Escherichia coli K-12 : B1765; hypothetical protein 1533002 ydjA 1077947 ydjA Shigella flexneri 2a str. 2457T hypothetical protein NP_837143.1 1532451 D 198215 CDS NP_837144.1 30062973 1080913 1533119..1534162 1 NC_004741.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1534162 selD 1080913 selD Shigella flexneri 2a str. 2457T selenophosphate synthetase NP_837144.1 1533119 D 198215 CDS NP_837145.1 30062974 1077948 1534167..1536128 1 NC_004741.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 1536128 topB 1077948 topB Shigella flexneri 2a str. 2457T DNA topoisomerase III NP_837145.1 1534167 D 198215 CDS NP_837146.2 161486494 1077950 1538704..1539069 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1539069 1077950 S1578 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_837146.2 1538704 D 198215 CDS NP_837147.2 161486493 1077951 1539027..1539932 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1539932 1077951 S1579 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_837147.2 1539027 D 198215 CDS NP_837148.1 30062977 1078021 1540327..1540599 1 NC_004741.1 residues 1 to 90 of 90 are 98.88 pct identical to residues 1 to 90 of 90 from Escherichia coli K-12 : B1760; hypothetical protein 1540599 1078021 S1580 Shigella flexneri 2a str. 2457T hypothetical protein NP_837148.1 1540327 D 198215 CDS NP_837149.1 30062978 1077954 complement(1540565..1540972) 1 NC_004741.1 residues 1 to 120 of 135 are 96.66 pct identical to residues 1 to 120 of 135 from Escherichia coli K-12 : B1759; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1540972 1077954 S1581 Shigella flexneri 2a str. 2457T pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase NP_837149.1 1540565 R 198215 CDS NP_837150.1 30062979 1077843 1541059..1541679 1 NC_004741.1 residues 1 to 206 of 206 are 88.83 pct identical to residues 3 to 208 of 208 from Escherichia coli K-12 : B1758; cytochrome oxidase 1541679 1077843 S1582 Shigella flexneri 2a str. 2457T cytochrome oxidase NP_837150.1 1541059 D 198215 CDS NP_837151.1 30062980 1080918 complement(1543062..1543715) 1 NC_004741.1 residues 1 to 217 of 217 are 93.08 pct identical to residues 1 to 217 of 217 from Escherichia coli K-12 : B1756; ATP-binding component of a transport system 1543715 1080918 S1584 Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_837151.1 1543062 R 198215 CDS NP_837152.1 30062981 1077960 1546096..1547424 1 NC_004741.1 residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 1547424 1077960 S1588 Shigella flexneri 2a str. 2457T IS4 orf NP_837152.1 1546096 D 198215 CDS NP_837153.1 30062982 1077992 complement(1547774..1548322) 1 NC_004741.1 residues 1 to 182 of 182 are 92.30 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 : B1753; hypothetical protein 1548322 ynjA 1077992 ynjA Shigella flexneri 2a str. 2457T hypothetical protein NP_837153.1 1547774 R 198215 CDS NP_837154.1 30062983 1077961 complement(1548322..1549026) 1 NC_004741.1 residues 1 to 233 of 234 are 91.41 pct identical to residues 2 to 234 of 235 from Escherichia coli K-12 : B1752; hypothetical protein 1549026 ydjZ 1077961 ydjZ Shigella flexneri 2a str. 2457T hypothetical protein NP_837154.1 1548322 R 198215 CDS NP_837155.1 30062984 1077984 complement(1549044..1549883) 1 NC_004741.1 residues 1 to 279 of 279 are 92.47 pct identical to residues 1 to 279 of 279 from Escherichia coli K-12 : B1751; hypothetical protein 1549883 ydjY 1077984 ydjY Shigella flexneri 2a str. 2457T hypothetical protein NP_837155.1 1549044 R 198215 CDS NP_837156.1 30062985 1077962 complement(1549726..1550436) 1 NC_004741.1 residues 1 to 236 of 236 are 91.10 pct identical to residues 17 to 252 of 252 from Escherichia coli K-12 : B1750; hypothetical protein 1550436 ydjX 1077962 ydjX Shigella flexneri 2a str. 2457T hypothetical protein NP_837156.1 1549726 R 198215 CDS NP_837157.1 30062986 1077965 complement(1550603..1551409) 1 NC_004741.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1551409 xthA 1077965 xthA Shigella flexneri 2a str. 2457T exonuclease III NP_837157.1 1550603 R 198215 CDS NP_837158.1 30062987 1077968 1553075..1554106 1 NC_004741.1 residues 1 to 343 of 343 are 99.70 pct identical to residues 2 to 344 of 344 from Escherichia coli K-12 : B1747; arginine succinyltransferase 1554106 1077968 S1596 Shigella flexneri 2a str. 2457T arginine succinyltransferase NP_837158.1 1553075 D 198215 CDS NP_837159.1 30062988 1077920 1554103..1555581 1 NC_004741.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 1555581 astD 1077920 astD Shigella flexneri 2a str. 2457T succinylglutamic semialdehyde dehydrogenase NP_837159.1 1554103 D 198215 CDS NP_837160.1 30062989 1077994 1556904..1557872 1 NC_004741.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1557872 ydjS 1077994 ydjS Shigella flexneri 2a str. 2457T succinylglutamate desuccinylase NP_837160.1 1556904 D 198215 CDS NP_837161.1 30062990 1077971 1558202..1558687 1 NC_004741.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein 1558687 spy 1077971 spy Shigella flexneri 2a str. 2457T periplasmic protein NP_837161.1 1558202 D 198215 CDS NP_837162.1 30062991 1077972 1558890..1559465 1 NC_004741.1 residues 1 to 191 of 191 are 98.42 pct identical to residues 22 to 212 of 212 from Escherichia coli K-12 : B1742; hypothetical protein 1559465 1077972 S1601 Shigella flexneri 2a str. 2457T hypothetical protein NP_837162.1 1558890 D 198215 CDS NP_837163.1 30062992 1077970 complement(1559425..1560312) 1 NC_004741.1 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1560312 1077970 S1602 Shigella flexneri 2a str. 2457T nucleotide excision repair endonuclease NP_837163.1 1559425 R 198215 CDS NP_837164.1 30062993 1077973 complement(1560542..1561369) 1 NC_004741.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1561369 nadE 1077973 nadE Shigella flexneri 2a str. 2457T NAD synthetase NP_837164.1 1560542 R 198215 CDS NP_837165.1 30062994 1079640 1561571..1561909 1 NC_004741.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1561909 osmE 1079640 osmE Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator OsmE NP_837165.1 1561571 D 198215 CDS NP_837166.1 30062995 1077975 1562208..1562528 1 NC_004741.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; N,N'-diacetylchitobiose-specific PTS system transporter subunit IIB 1562528 celA 1077975 celA Shigella flexneri 2a str. 2457T N,N'-diacetylchitobiose-specific PTS system transporter subunit IIB NP_837166.1 1562208 D 198215 CDS NP_837167.1 30062996 1077978 1564020..1564370 1 NC_004741.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; N,N'-diacetylchitobiose-specific PTS system transporter subunit IIA 1564370 celC 1077978 celC Shigella flexneri 2a str. 2457T N,N'-diacetylchitobiose-specific PTS system transporter subunit IIA NP_837167.1 1564020 D 198215 CDS NP_837168.1 30062997 1077941 complement(1565070..1565573) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1565573 1077941 S1609 Shigella flexneri 2a str. 2457T IS1 orfB NP_837168.1 1565070 R 198215 CDS NP_837169.1 30062998 1077980 complement(1565492..1565767) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1565767 1077980 S1610 Shigella flexneri 2a str. 2457T IS1 orfA NP_837169.1 1565492 R 198215 CDS NP_837170.1 30062999 1079635 1566102..1567454 1 NC_004741.1 residues 1 to 450 of 450 are 98.44 pct identical to residues 1 to 450 of 450 from Escherichia coli K-12 : B1734; cryptic phospho-beta-glucosidase; cryptic 1567454 celF 1079635 celF Shigella flexneri 2a str. 2457T cryptic phospho-beta-glucosidase; cryptic NP_837170.1 1566102 D 198215 CDS NP_837171.1 30063000 1077981 1567467..1568225 1 NC_004741.1 residues 1 to 252 of 252 are 92.85 pct identical to residues 1 to 249 of 249 from Escherichia coli K-12 : B1733; hypothetical protein 1568225 ydjC 1077981 ydjC Shigella flexneri 2a str. 2457T hypothetical protein NP_837171.1 1567467 D 198215 CDS NP_837172.1 30063001 1077829 complement(1568272..1570533) 1 NC_004741.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1570533 katE 1077829 katE Shigella flexneri 2a str. 2457T hydroperoxidase II NP_837172.1 1568272 R 198215 CDS NP_837173.1 30063002 1077982 1570716..1570979 1 NC_004741.1 residues 1 to 87 of 87 are 100.00 pct identical to residues 1 to 87 of 87 from Escherichia coli K-12 : B1731; cell division modulator 1570979 1077982 S1614 Shigella flexneri 2a str. 2457T cell division modulator NP_837173.1 1570716 D 198215 CDS NP_837174.1 30063003 1078001 complement(1572008..1572511) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1572511 1078001 S1616 Shigella flexneri 2a str. 2457T IS1 orfB NP_837174.1 1572008 R 198215 CDS NP_837175.1 30063004 1077983 complement(1572430..1572705) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1572705 1077983 S1617 Shigella flexneri 2a str. 2457T IS1 orfA NP_837175.1 1572430 R 198215 CDS NP_837176.1 30063005 1077985 complement(1574375..1574965) 1 NC_004741.1 residues 1 to 196 of 196 are 100.00 pct identical to residues 5 to 200 of 200 from Escherichia coli K-12 : B1728; hypothetical protein 1574965 1077985 S1619 Shigella flexneri 2a str. 2457T hypothetical protein NP_837176.1 1574375 R 198215 CDS NP_837177.1 30063006 1077421 complement(1575128..1575796) 1 NC_004741.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1575796 yniC 1077421 yniC Shigella flexneri 2a str. 2457T 2-deoxyglucose-6-phosphatase NP_837177.1 1575128 R 198215 CDS NP_837178.1 30063007 1077986 1575943..1576479 1 NC_004741.1 residues 1 to 178 of 178 are 98.87 pct identical to residues 1 to 178 of 178 from Escherichia coli K-12 : B1726; hypothetical protein 1576479 1077986 S1621 Shigella flexneri 2a str. 2457T hypothetical protein NP_837178.1 1575943 D 198215 CDS NP_837179.1 30063008 1080917 complement(1576520..1577380) 1 NC_004741.1 residues 1 to 286 of 286 are 99.30 pct identical to residues 1 to 286 of 286 from Escherichia coli K-12 : B1725; hypothetical protein 1577380 1080917 S1622 Shigella flexneri 2a str. 2457T hypothetical protein NP_837179.1 1576520 R 198215 CDS NP_837180.1 30063009 1077987 complement(1577486..1577776) 1 NC_004741.1 residues 1 to 96 of 96 are 98.95 pct identical to residues 1 to 96 of 96 from Escherichia coli K-12 : B1724; hypothetical protein 1577776 1077987 S1623 Shigella flexneri 2a str. 2457T hypothetical protein NP_837180.1 1577486 R 198215 CDS NP_837181.1 30063010 1077958 complement(1577877..1578806) 1 NC_004741.1 residues 1 to 309 of 309 are 99.35 pct identical to residues 1 to 309 of 309 from Escherichia coli K-12 : B1723; suppressor of pfkA; 6-phosphofructokinase 1578806 pfkB 1077958 pfkB Shigella flexneri 2a str. 2457T 6-phosphofructokinase NP_837181.1 1577877 R 198215 CDS NP_837182.1 30063011 1077989 1579126..1579851 1 NC_004741.1 residues 1 to 241 of 241 are 99.58 pct identical to residues 12 to 252 of 252 from Escherichia coli K-12 : B1722; hypothetical protein 1579851 1077989 S1625 Shigella flexneri 2a str. 2457T hypothetical protein NP_837182.1 1579126 D 198215 CDS NP_837183.1 30063012 1080915 complement(1581158..1581661) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1581661 1080915 S1627 Shigella flexneri 2a str. 2457T IS1 orfB NP_837183.1 1581158 R 198215 CDS NP_837184.1 30063013 1077993 complement(1581580..1581855) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1581855 1077993 S1628 Shigella flexneri 2a str. 2457T IS1 orfA NP_837184.1 1581580 R 198215 CDS NP_837185.1 30063014 1077996 1582814..1584742 1 NC_004741.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1584742 thrS 1077996 thrS Shigella flexneri 2a str. 2457T threonyl-tRNA synthetase NP_837185.1 1582814 D 198215 CDS NP_837186.1 30063015 1077906 1584854..1585288 1 NC_004741.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1585288 infC 1077906 infC Shigella flexneri 2a str. 2457T translation initiation factor IF-3 NP_837186.1 1584854 D 198215 CDS NP_837187.1 30063016 1077997 1585385..1585582 1 NC_004741.1 residues 1 to 65 of 65 are 70.76 pct identical to residues 1 to 65 of 65 from Escherichia coli K-12 : B1717; 50S ribosomal protein L35 1585582 rpmI 1077997 rpmI Shigella flexneri 2a str. 2457T 50S ribosomal protein L35 NP_837187.1 1585385 D 198215 CDS NP_837188.1 30063017 1077945 1585635..1585991 1 NC_004741.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1585991 rplT 1077945 rplT Shigella flexneri 2a str. 2457T 50S ribosomal protein L20 NP_837188.1 1585635 D 198215 CDS NP_837190.1 30063019 1077999 1586441..1587424 1 NC_004741.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1587424 pheS 1077999 pheS Shigella flexneri 2a str. 2457T phenylalanyl-tRNA synthetase subunit alpha NP_837190.1 1586441 D 198215 CDS NP_837191.1 30063020 1079642 1587439..1589826 1 NC_004741.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1589826 pheT 1079642 pheT Shigella flexneri 2a str. 2457T phenylalanyl-tRNA synthetase subunit beta NP_837191.1 1587439 D 198215 CDS NP_837192.1 30063021 1078000 1589831..1590130 1 NC_004741.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1590130 ihfA 1078000 ihfA Shigella flexneri 2a str. 2457T integration host factor subunit alpha NP_837192.1 1589831 D 198215 CDS NP_837193.1 30063022 1077953 1590231..1591211 1 NC_004741.1 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1591211 btuC 1077953 btuC Shigella flexneri 2a str. 2457T vtamin B12-transporter permease NP_837193.1 1590231 D 198215 CDS NP_837194.1 30063023 1078002 1591274..1591825 1 NC_004741.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase 1591825 btuE 1078002 btuE Shigella flexneri 2a str. 2457T glutathione peroxidase NP_837194.1 1591274 D 198215 CDS NP_837195.1 30063024 1078045 1591825..1592574 1 NC_004741.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1592574 btuD 1078045 btuD Shigella flexneri 2a str. 2457T vitamin B12-transporter ATPase NP_837195.1 1591825 D 198215 CDS NP_837196.1 30063025 1078003 1592652..1593116 1 NC_004741.1 residues 1 to 154 of 154 are 98.70 pct identical to residues 1 to 154 of 154 from Escherichia coli K-12 : B1708; lipoprotein 1593116 nlpC 1078003 nlpC Shigella flexneri 2a str. 2457T lipoprotein NP_837196.1 1592652 D 198215 CDS NP_837197.1 30063026 1077944 1593363..1594076 1 NC_004741.1 residues 1 to 237 of 237 are 97.04 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B1707; hypothetical protein 1594076 1077944 S1641 Shigella flexneri 2a str. 2457T hypothetical protein NP_837197.1 1593363 D 198215 CDS NP_837198.1 30063027 1078004 1594140..1595576 1 NC_004741.1 residues 1 to 478 of 478 are 97.69 pct identical to residues 1 to 478 of 478 from Escherichia coli K-12 : B1706; hypothetical protein 1595576 1078004 S1642 Shigella flexneri 2a str. 2457T hypothetical protein NP_837198.1 1594140 D 198215 CDS NP_837199.1 30063028 1078047 complement(1595580..1595771) 1 NC_004741.1 residues 1 to 63 of 63 are 98.41 pct identical to residues 1 to 63 of 63 from Escherichia coli K-12 : B1705; hypothetical protein 1595771 ydiE 1078047 ydiE Shigella flexneri 2a str. 2457T hypothetical protein NP_837199.1 1595580 R 198215 CDS NP_837200.1 30063029 1079648 complement(1595903..1596949) 1 NC_004741.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1596949 aroH 1079648 aroH Shigella flexneri 2a str. 2457T phospho-2-dehydro-3-deoxyheptonate aldolase NP_837200.1 1595903 R 198215 CDS NP_837201.1 30063030 1078005 complement(1597106..1597939) 1 NC_004741.1 residues 1 to 277 of 277 are 95.66 pct identical to residues 1 to 277 of 277 from Escherichia coli K-12 : B1703; hypothetical protein 1597939 ydiA 1078005 ydiA Shigella flexneri 2a str. 2457T hypothetical protein NP_837201.1 1597106 R 198215 CDS NP_837202.1 30063031 1078033 1598272..1600650 1 NC_004741.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1600650 ppsA 1078033 ppsA Shigella flexneri 2a str. 2457T phosphoenolpyruvate synthase NP_837202.1 1598272 D 198215 CDS NP_837203.1 30063032 1078007 complement(1600707..1602407) 1 NC_004741.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 1602407 ydiD 1078007 ydiD Shigella flexneri 2a str. 2457T short chain acyl-CoA synthetase NP_837203.1 1600707 R 198215 CDS NP_837204.1 30063033 1078009 complement(1602410..1602703) 1 NC_004741.1 residues 1 to 97 of 97 are 95.87 pct identical to residues 1 to 97 of 97 from Escherichia coli K-12 : B1700; hypothetical protein 1602703 ydiT 1078009 ydiT Shigella flexneri 2a str. 2457T hypothetical protein NP_837204.1 1602410 R 198215 CDS NP_837205.1 30063034 1080916 complement(1602700..1603989) 1 NC_004741.1 residues 1 to 429 of 429 are 91.60 pct identical to residues 1 to 429 of 429 from Escherichia coli K-12 : B1699; hypothetical protein 1603989 ydiS 1080916 ydiS Shigella flexneri 2a str. 2457T hypothetical protein NP_837205.1 1602700 R 198215 CDS NP_837206.1 30063035 1078010 complement(1604045..1604983) 1 NC_004741.1 May play a role in a redox process; electron transfer flavoprotein subunit YdiR 1604983 ydiR 1078010 ydiR Shigella flexneri 2a str. 2457T electron transfer flavoprotein subunit YdiR NP_837206.1 1604045 R 198215 CDS NP_837207.1 30063036 1078011 complement(1605003..1605767) 1 NC_004741.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; electron transfer flavoprotein YdiQ 1605767 ydiQ 1078011 ydiQ Shigella flexneri 2a str. 2457T electron transfer flavoprotein YdiQ NP_837207.1 1605003 R 198215 CDS NP_837208.1 30063037 1078048 1606086..1606586 1 NC_004741.1 residues 1 to 160 of 166 are 99.37 pct identical to residues 1 to 160 of 303 from Escherichia coli K-12 : B1696; ARAC-type regulatory protein 1606586 1078048 S1652 Shigella flexneri 2a str. 2457T ARAC-type regulatory protein NP_837208.1 1606086 D 198215 CDS NP_837209.1 30063038 1078014 1607022..1607315 1 NC_004741.1 residues 1 to 97 of 97 are 81.44 pct identical to residues 35 to 131 of 131 from GenPept : >gb|AAL72404.1| (AF386526) transposase [Shigella flexneri 2a]; partial; IS1 1607315 1078014 S1653 Shigella flexneri 2a str. 2457T IS1 NP_837209.1 1607022 D 198215 CDS NP_837210.1 30063039 1077977 complement(1607878..1608639) 1 NC_004741.1 regulates the cellular response to acid resistance; transcriptional regulator YdeO 1608639 1077977 S1654 Shigella flexneri 2a str. 2457T transcriptional regulator YdeO NP_837210.1 1607878 R 198215 CDS NP_837211.1 30063040 1078015 complement(1608707..1608910) 1 NC_004741.1 residues 1 to 64 of 67 are 79.68 pct identical to residues 1 to 64 of 65 from Escherichia coli K-12 : B1500; hypothetical protein 1608910 1078015 S1655 Shigella flexneri 2a str. 2457T hypothetical protein NP_837211.1 1608707 R 198215 CDS NP_837212.1 30063041 1077899 complement(1609158..1611437) 1 NC_004741.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; oxidoreductase 1611437 1077899 S1656 Shigella flexneri 2a str. 2457T oxidoreductase NP_837212.1 1609158 R 198215 CDS NP_837213.1 30063042 1078017 1612576..1612851 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1612851 1078017 S1658 Shigella flexneri 2a str. 2457T IS1 orfA NP_837213.1 1612576 D 198215 CDS NP_837214.1 30063043 1080949 1612770..1613273 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1613273 1080949 S1659 Shigella flexneri 2a str. 2457T IS1 orfB NP_837214.1 1612770 D 198215 CDS NP_837215.1 30063044 1078194 1613481..1614194 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 1614194 1078194 S1660 Shigella flexneri 2a str. 2457T IS600 orfB NP_837215.1 1613481 D 198215 CDS NP_837216.1 30063045 1078019 complement(1614219..1614398) 1 NC_004741.1 residues 1 to 59 of 59 are 67.79 pct identical to residues 1 to 59 of 71 from GenPept : >emb|CAC12891.1| (AJ279086) S protein [Shigella sonnei bacteriophage 7888]; lysis protein S of prophage CP-933V 1614398 1078019 S1661 Shigella flexneri 2a str. 2457T lysis protein S of prophage CP-933V NP_837216.1 1614219 R 198215 CDS NP_837217.1 30063046 1078020 complement(1614706..1614909) 1 NC_004741.1 residues 1 to 67 of 67 are 99.00 pct identical to residues 1 to 66 of 66 from NRprotein_Feb03 : >ref|NP_753340.1| Hypothetical protein [Escherichia coli CFT073] gb|AAN79900.1|AE016759_174 Hypothetical protein [Escherichia coli CFT073]; hypothetical protein 1614909 1078020 S4818 Shigella flexneri 2a str. 2457T hypothetical protein NP_837217.1 1614706 R 198215 CDS NP_837218.1 30063047 1078022 complement(1617635..1617991) 1 NC_004741.1 residues 5 to 113 of 118 are 40.36 pct identical to residues 6 to 114 of 120 from Escherichia coli K-12 : B0550; endodeoxyribonuclease RUS (Holliday junction resolvase) 1617991 rus 1078022 rus Shigella flexneri 2a str. 2457T endodeoxyribonuclease RUS (Holliday junction resolvase) NP_837218.1 1617635 R 198215 CDS NP_837219.1 30063048 1080999 complement(1619400..1619648) 1 NC_004741.1 residues 1 to 82 of 82 are 93.90 pct identical to residues 2 to 83 of 83 from Escherichia coli K-12 : B1561; hypothetical protein 1619648 rem 1080999 rem Shigella flexneri 2a str. 2457T hypothetical protein NP_837219.1 1619400 R 198215 CDS NP_837220.1 30063049 1078024 complement(1619869..1620024) 1 NC_004741.1 residues 1 to 51 of 51 are 100.00 pct identical to residues 1 to 51 of 51 from Escherichia coli K-12 : B1562; prophage maintenance protein 1620024 relF 1078024 relF Shigella flexneri 2a str. 2457T prophage maintenance protein NP_837220.1 1619869 R 198215 CDS NP_837221.1 30063050 1078018 complement(1620096..1620383) 1 NC_004741.1 residues 1 to 95 of 95 are 100.00 pct identical to residues 1 to 95 of 95 from Escherichia coli K-12 : B1563; hypothetical protein 1620383 relE 1078018 relE Shigella flexneri 2a str. 2457T hypothetical protein NP_837221.1 1620096 R 198215 CDS NP_837222.1 30063051 1078025 complement(1620383..1620622) 1 NC_004741.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor; bifunctional antitoxin/transcriptional repressor RelB 1620622 relB 1078025 relB Shigella flexneri 2a str. 2457T bifunctional antitoxin/transcriptional repressor RelB NP_837222.1 1620383 R 198215 CDS NP_837223.1 30063052 1078028 complement(1620682..1621308) 1 NC_004741.1 residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB 1621308 b4285 1078028 b4285 Shigella flexneri 2a str. 2457T IS911 orfB NP_837223.1 1620682 R 198215 CDS NP_837224.1 30063053 1078032 complement(1621548..1621850) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 1621850 1078032 S1673 Shigella flexneri 2a str. 2457T IS911 orfA NP_837224.1 1621548 R 198215 CDS NP_837225.1 30063054 1078034 complement(1622201..1622914) 1 NC_004741.1 residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 1622914 1078034 S1675 Shigella flexneri 2a str. 2457T IS600 orfB NP_837225.1 1622201 R 198215 CDS NP_837226.1 30063055 1078055 complement(1623055..1623357) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 1623357 1078055 S1676 Shigella flexneri 2a str. 2457T IS600 orfA NP_837226.1 1623055 R 198215 CDS NP_837227.1 30063056 1078068 1624527..1625987 1 NC_004741.1 residues 1 to 486 of 486 are 98.35 pct identical to residues 1 to 486 of 486 from Escherichia coli K-12 : B1542; oxidoreductase 1625987 ydfI 1078068 ydfI Shigella flexneri 2a str. 2457T oxidoreductase NP_837227.1 1624527 D 198215 CDS NP_837228.1 30063057 1078049 complement(1626023..1626226) 1 NC_004741.1 residues 1 to 67 of 67 are 100.00 pct identical to residues 1 to 67 of 67 from Escherichia coli K-12 : B1541; hypothetical protein 1626226 1078049 S1679 Shigella flexneri 2a str. 2457T hypothetical protein NP_837228.1 1626023 R 198215 CDS NP_837229.1 30063058 1078036 complement(1626404..1627090) 1 NC_004741.1 residues 1 to 228 of 228 are 100.00 pct identical to residues 1 to 228 of 228 from Escherichia coli K-12 : B1540; hypothetical protein 1627090 ydfH 1078036 ydfH Shigella flexneri 2a str. 2457T hypothetical protein NP_837229.1 1626404 R 198215 CDS NP_837230.1 30063059 1076528 complement(1627179..1627925) 1 NC_004741.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1627925 ydfG 1076528 ydfG Shigella flexneri 2a str. 2457T 3-hydroxy acid dehydrogenase NP_837230.1 1627179 R 198215 CDS NP_837231.1 30063060 1078037 1628062..1630107 1 NC_004741.1 residues 1 to 681 of 681 are 94.71 pct identical to residues 1 to 681 of 681 from Escherichia coli K-12 : B1538; dipeptidyl carboxypeptidase II 1630107 dcp 1078037 dcp Shigella flexneri 2a str. 2457T dipeptidyl carboxypeptidase II NP_837231.1 1628062 D 198215 CDS NP_837232.1 30063061 1078012 complement(1630152..1630670) 1 NC_004741.1 residues 1 to 154 of 172 are 86.36 pct identical to residues 1 to 154 of 172 from Escherichia coli K-12 : B1537; competence damage-inducible protein A 1630670 ydeJ 1078012 ydeJ Shigella flexneri 2a str. 2457T competence damage-inducible protein A NP_837232.1 1630152 R 198215 CDS NP_837233.1 30063062 1078041 1630946..1631179 1 NC_004741.1 residues 1 to 75 of 77 are 97.33 pct identical to residues 1 to 75 of 130 from Escherichia coli K-12 : B1536; hypothetical protein 1631179 ydeI 1078041 ydeI Shigella flexneri 2a str. 2457T hypothetical protein NP_837233.1 1630946 D 198215 CDS NP_837234.1 30063063 1080479 1631236..1631538 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 1631538 1080479 S1685 Shigella flexneri 2a str. 2457T IS600 NP_837234.1 1631236 D 198215 CDS NP_837235.1 30063064 1078042 1631679..1632392 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 1632392 1078042 S1686 Shigella flexneri 2a str. 2457T IS600 NP_837235.1 1631679 D 198215 CDS NP_837236.1 30063065 1078043 complement(1632862..1633980) 1 NC_004741.1 residues 2 to 372 of 372 are 95.41 pct identical to residues 25 to 395 of 395 from Escherichia coli K-12 : B1534; transporter 1633980 ydeF 1078043 ydeF Shigella flexneri 2a str. 2457T transporter NP_837236.1 1632862 R 198215 CDS NP_837237.2 161486492 1078044 1634244..1635143 1 NC_004741.1 residues 1 to 266 of 266 are 98.87 pct identical to residues 1 to 266 of 266 from Escherichia coli K-12 : B1533; O-acetylserine/cysteine export protein 1635143 ydeD 1078044 ydeD Shigella flexneri 2a str. 2457T O-acetylserine/cysteine export protein NP_837237.2 1634244 D 198215 CDS NP_837238.1 30063067 1078635 complement(1635174..1635392) 1 NC_004741.1 residues 1 to 72 of 72 are 62.50 pct identical to residues 1 to 72 of 72 from Escherichia coli K-12 : B1532; hypothetical protein 1635392 marB 1078635 marB Shigella flexneri 2a str. 2457T hypothetical protein NP_837238.1 1635174 R 198215 CDS NP_837239.1 30063068 1078046 complement(1635424..1635807) 1 NC_004741.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1635807 marA 1078046 marA Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator MarA NP_837239.1 1635424 R 198215 CDS NP_837240.2 161486491 1077964 complement(1635827..1636261) 1 NC_004741.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1636261 marR 1077964 marR Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor MarR NP_837240.2 1635827 R 198215 CDS NP_837241.1 30063070 1078050 1636473..1637138 1 NC_004741.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1637138 ydeB 1078050 ydeB Shigella flexneri 2a str. 2457T multiple drug resistance protein MarC NP_837241.1 1636473 D 198215 CDS NP_837242.1 30063071 1078244 complement(1637163..1638353) 1 NC_004741.1 residues 1 to 396 of 396 are 87.12 pct identical to residues 1 to 396 of 396 from Escherichia coli K-12 : B1528; sugar efflux transporter 1638353 ydeA 1078244 ydeA Shigella flexneri 2a str. 2457T sugar efflux transporter NP_837242.1 1637163 R 198215 CDS NP_837243.1 30063072 1078052 complement(1638503..1639618) 1 NC_004741.1 residues 1 to 371 of 371 are 96.76 pct identical to residues 1 to 371 of 371 from Escherichia coli K-12 : B1527; hypothetical protein 1639618 1078052 S1694 Shigella flexneri 2a str. 2457T hypothetical protein NP_837243.1 1638503 R 198215 CDS NP_837244.1 30063073 1078061 1640697..1641623 1 NC_004741.1 catalyzes the formation of glutamate from glutamine; glutaminase 1641623 yneH 1078061 yneH Shigella flexneri 2a str. 2457T glutaminase NP_837244.1 1640697 D 198215 CDS NP_837245.1 30063074 1078057 1641623..1641967 1 NC_004741.1 residues 1 to 114 of 114 are 85.96 pct identical to residues 1 to 114 of 119 from Escherichia coli K-12 : B1523; hypothetical protein 1641967 1078057 S1697 Shigella flexneri 2a str. 2457T hypothetical protein NP_837245.1 1641623 D 198215 CDS NP_837246.1 30063075 1076937 1642592..1643539 1 NC_004741.1 residues 11 to 325 of 325 are 92.69 pct identical to residues 1 to 315 of 315 from Escherichia coli K-12 : B1522; hypothetical protein 1643539 1076937 S1698 Shigella flexneri 2a str. 2457T hypothetical protein NP_837246.1 1642592 D 198215 CDS NP_837247.1 30063076 1078058 1643766..1645217 1 NC_004741.1 catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1645217 uxaB 1078058 uxaB Shigella flexneri 2a str. 2457T altronate oxidoreductase NP_837247.1 1643766 D 198215 CDS NP_837248.1 30063077 1078745 1647060..1648025 1 NC_004741.1 residues 1 to 321 of 321 are 99.68 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B1520; hypothetical protein 1648025 1078745 S1701 Shigella flexneri 2a str. 2457T hypothetical protein NP_837248.1 1647060 D 198215 CDS NP_837249.1 30063078 1078059 complement(1648029..1648787) 1 NC_004741.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1648787 1078059 S1702 Shigella flexneri 2a str. 2457T trans-aconitate 2-methyltransferase NP_837249.1 1648029 R 198215 CDS NP_837250.1 30063079 1078060 complement(1648827..1649117) 1 NC_004741.1 residues 1 to 96 of 96 are 98.95 pct identical to residues 1 to 96 of 96 from Escherichia coli K-12 : B1518; autoinducer-2 (AI-2) modifying protein LsrG 1649117 1078060 S1703 Shigella flexneri 2a str. 2457T autoinducer-2 (AI-2) modifying protein LsrG NP_837250.1 1648827 R 198215 CDS NP_837251.1 30063080 1078175 complement(1649141..1649923) 1 NC_004741.1 residues 1 to 260 of 260 are 98.46 pct identical to residues 32 to 291 of 291 from Escherichia coli K-12 : B1517; part of yneB; aldolase 1649923 1078175 S1704 Shigella flexneri 2a str. 2457T aldolase NP_837251.1 1649141 R 198215 CDS NP_837252.2 161486490 1080940 complement(1649936..1650841) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1650841 1080940 S1705 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_837252.2 1649936 R 198215 CDS NP_837253.2 161486489 1078062 complement(1650799..1651164) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1651164 1078062 S1706 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_837253.2 1650799 R 198215 CDS NP_837254.1 30063083 1078072 complement(1652321..1653274) 1 NC_004741.1 residues 1 to 317 of 317 are 89.90 pct identical to residues 1 to 317 of 317 from Escherichia coli K-12 : B1512; sorC family transcriptional regulator 1653274 ydeW 1078072 ydeW Shigella flexneri 2a str. 2457T sorC family transcriptional regulator NP_837254.1 1652321 R 198215 CDS NP_837255.1 30063084 1078065 1653523..1655058 1 NC_004741.1 residues 1 to 511 of 511 are 98.43 pct identical to residues 1 to 511 of 511 from Escherichia coli K-12 : B1513; ATP-binding component of a transport system 1655058 1078065 S1709 Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_837255.1 1653523 D 198215 CDS NP_837256.1 30063085 1078066 1655052..1656080 1 NC_004741.1 residues 1 to 342 of 342 are 83.62 pct identical to residues 1 to 342 of 342 from Escherichia coli K-12 : B1514; transport system permease 1656080 ydeY 1078066 ydeY Shigella flexneri 2a str. 2457T transport system permease NP_837256.1 1655052 D 198215 CDS NP_837257.1 30063086 1079017 1656080..1657072 1 NC_004741.1 residues 1 to 330 of 330 are 76.36 pct identical to residues 1 to 330 of 330 from Escherichia coli K-12 : B1515; transport system permease 1657072 ydeZ 1079017 ydeZ Shigella flexneri 2a str. 2457T transport system permease NP_837257.1 1656080 D 198215 CDS NP_837258.2 161486488 1078649 1658322..1658687 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1658687 1078649 S1714 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_837258.2 1658322 D 198215 CDS NP_837259.2 161486487 1078070 1658645..1659550 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1659550 1078070 S1715 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_837259.2 1658645 D 198215 CDS NP_837260.1 30063089 1078071 complement(1659600..1660412) 1 NC_004741.1 residues 1 to 270 of 270 are 95.92 pct identical to residues 10 to 279 of 279 from GenPept : >gb|AAG53988.1|AF327445_2 (AF327445) transposase B [Pantoea agglomerans]; ISEhe3 orfB 1660412 1078071 S1716 Shigella flexneri 2a str. 2457T ISEhe3 orfB NP_837260.1 1659600 R 198215 CDS NP_837261.1 30063090 1080569 complement(1660469..1660747) 1 NC_004741.1 residues 1 to 92 of 92 are 92.39 pct identical to residues 3 to 94 of 94 from GenPept : >gb|AAG53987.1|AF327445_1 (AF327445) transposase A [Pantoea agglomerans]; ISEhe3 orfA 1660747 1080569 S1717 Shigella flexneri 2a str. 2457T ISEhe3 orfA NP_837261.1 1660469 R 198215 CDS NP_837262.1 30063091 1078073 complement(1660824..1662038) 1 NC_004741.1 residues 1 to 403 of 404 are 99.75 pct identical to residues 1 to 403 of 404 from Escherichia coli K-12 : B1581; starvation sensing protein 1662038 rspA 1078073 rspA Shigella flexneri 2a str. 2457T starvation sensing protein NP_837262.1 1660824 R 198215 CDS NP_837263.1 30063092 1078267 complement(1662244..1662570) 1 NC_004741.1 residues 1 to 108 of 108 are 99.07 pct identical to residues 1 to 108 of 108 from Escherichia coli K-12 : B1582; hypothetical protein 1662570 1078267 S1719 Shigella flexneri 2a str. 2457T hypothetical protein NP_837263.1 1662244 R 198215 CDS NP_837264.1 30063093 1078075 1662705..1663046 1 NC_004741.1 residues 1 to 113 of 113 are 89.38 pct identical to residues 1 to 113 of 113 from Escherichia coli K-12 : B1583; hypothetical protein 1663046 1078075 S1720 Shigella flexneri 2a str. 2457T hypothetical protein NP_837264.1 1662705 D 198215 CDS NP_837265.2 161486486 1078076 complement(1663644..1664354) 1 NC_004741.1 residues 1 to 248 of 248 are 100.00 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 : B1585; hypothetical protein 1664354 ynfC 1078076 ynfC Shigella flexneri 2a str. 2457T hypothetical protein NP_837265.2 1663644 R 198215 CDS NP_837266.1 30063095 1078077 1664462..1664767 1 NC_004741.1 residues 1 to 101 of 101 are 83.16 pct identical to residues 15 to 115 of 115 from Escherichia coli K-12 : B1586; hypothetical protein 1664767 1078077 S1723 Shigella flexneri 2a str. 2457T hypothetical protein NP_837266.1 1664462 D 198215 CDS NP_837267.1 30063096 1078947 complement(1667110..1668099) 1 NC_004741.1 residues 3 to 327 of 329 are 91.69 pct identical to residues 2 to 326 of 327 from GenPept : >emb|CAD02863.1| (AL627277) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 1668099 1078947 S1727 Shigella flexneri 2a str. 2457T hypothetical protein NP_837267.1 1667110 R 198215 CDS NP_837268.1 30063097 1078518 complement(1668186..1668677) 1 NC_004741.1 residues 1 to 163 of 163 are 84.66 pct identical to residues 1 to 163 of 163 from GenPept : >emb|CAD02864.1| (AL627277) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 1668677 1078518 S1728 Shigella flexneri 2a str. 2457T hypothetical protein NP_837268.1 1668186 R 198215 CDS NP_837269.1 30063098 1078082 complement(1668998..1669498) 1 NC_004741.1 no significant similarities; hypothetical protein 1669498 1078082 S1730 Shigella flexneri 2a str. 2457T hypothetical protein NP_837269.1 1668998 R 198215 CDS NP_837270.1 30063099 1078661 complement(1669488..1670003) 1 NC_004741.1 no significant similarities; hypothetical protein 1670003 1078661 S1731 Shigella flexneri 2a str. 2457T hypothetical protein NP_837270.1 1669488 R 198215 CDS NP_837271.1 30063100 1078083 complement(1670434..1670802) 1 NC_004741.1 no significant similarities; hypothetical protein 1670802 1078083 S1732 Shigella flexneri 2a str. 2457T hypothetical protein NP_837271.1 1670434 R 198215 CDS NP_837272.1 30063101 1079394 complement(1671771..1672397) 1 NC_004741.1 residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB 1672397 1079394 S1736 Shigella flexneri 2a str. 2457T IS911 orfB NP_837272.1 1671771 R 198215 CDS NP_837273.1 30063102 1078084 complement(1672637..1672939) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 1672939 1078084 S1738 Shigella flexneri 2a str. 2457T IS911 orfA NP_837273.1 1672637 R 198215 CDS NP_837274.1 30063103 1079680 complement(1673009..1673797) 1 NC_004741.1 residues 4 to 193 of 262 are 27.77 pct identical to residues 57 to 243 of 548 from GenPept : >emb|CAD02867.1| (AL627277) possible integrase [Salmonella enterica subsp. enterica serovar Typhi]; integrase 1673797 1079680 S1739 Shigella flexneri 2a str. 2457T integrase NP_837274.1 1673009 R 198215 CDS NP_837275.1 30063104 1078086 1677248..1677865 1 NC_004741.1 residues 1 to 205 of 205 are 99.51 pct identical to residues 1 to 205 of 205 from Escherichia coli K-12 : B1589; oxidoreductase, Fe-S subunit 1677865 1078086 S1742 Shigella flexneri 2a str. 2457T oxidoreductase, Fe-S subunit NP_837275.1 1677248 D 198215 CDS NP_837276.1 30063105 1078091 1677867..1678721 1 NC_004741.1 residues 1 to 284 of 284 are 90.49 pct identical to residues 1 to 284 of 284 from Escherichia coli K-12 : B1590; DMSO reductase anchor subunit 1678721 1078091 S1743 Shigella flexneri 2a str. 2457T DMSO reductase anchor subunit NP_837276.1 1677867 D 198215 CDS NP_837277.1 30063106 1078074 1678764..1679378 1 NC_004741.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1679378 1078074 S1744 Shigella flexneri 2a str. 2457T twin-argninine leader-binding protein DmsD NP_837277.1 1678764 D 198215 CDS NP_837278.2 161486485 1078087 1679573..1680829 1 NC_004741.1 residues 1 to 438 of 438 are 81.05 pct identical to residues 1 to 438 of 438 from Escherichia coli K-12 : B1592; voltage-gated ClC-type chloride channel ClcB 1680829 1078087 S1745 Shigella flexneri 2a str. 2457T voltage-gated ClC-type chloride channel ClcB NP_837278.2 1679573 D 198215 CDS NP_837279.1 30063108 1077932 complement(1680782..1681477) 1 NC_004741.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1681477 bioD 1077932 bioD Shigella flexneri 2a str. 2457T dithiobiotin synthetase NP_837279.1 1680782 R 198215 CDS NP_837280.1 30063109 1078093 complement(1681602..1682822) 1 NC_004741.1 residues 1 to 406 of 406 are 99.26 pct identical to residues 1 to 406 of 406 from Escherichia coli K-12 : B1594; NAGC-like transcriptional regulator 1682822 mlc 1078093 mlc Shigella flexneri 2a str. 2457T NAGC-like transcriptional regulator NP_837280.1 1681602 R 198215 CDS NP_837281.1 30063110 1077942 complement(1682957..1683868) 1 NC_004741.1 residues 1 to 303 of 303 are 94.71 pct identical to residues 1 to 297 of 297 from Escherichia coli K-12 : B1595; LYSR-type transcriptional regulator 1683868 ynfL 1077942 ynfL Shigella flexneri 2a str. 2457T LYSR-type transcriptional regulator NP_837281.1 1682957 R 198215 CDS NP_837282.2 161486484 1076487 1685652..1685960 1 NC_004741.1 required for growth and survival under moderately acid conditions; acid shock protein precursor 1685960 asr 1076487 asr Shigella flexneri 2a str. 2457T acid shock protein precursor NP_837282.2 1685652 D 198215 CDS NP_837283.1 30063112 1078095 1686236..1687057 1 NC_004741.1 residues 1 to 273 of 273 are 99.26 pct identical to residues 1 to 273 of 273 from Escherichia coli K-12 : B1598; hypothetical protein 1687057 1078095 S1751 Shigella flexneri 2a str. 2457T hypothetical protein NP_837283.1 1686236 D 198215 CDS NP_837284.1 30063113 1078134 complement(1687096..1687425) 1 NC_004741.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 1687425 1078134 S1752 Shigella flexneri 2a str. 2457T multidrug efflux system protein MdtI NP_837284.1 1687096 R 198215 CDS NP_837285.1 30063114 1078097 complement(1687412..1687777) 1 NC_004741.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 1687777 1078097 S1753 Shigella flexneri 2a str. 2457T multidrug efflux system protein MdtJ NP_837285.1 1687412 R 198215 CDS NP_837286.1 30063115 1077069 1688188..1689222 1 NC_004741.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transporter 1689222 tqsA 1077069 tqsA Shigella flexneri 2a str. 2457T transporter NP_837286.1 1688188 D 198215 CDS NP_837287.1 30063116 1078098 complement(1689247..1690635) 1 NC_004741.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1690635 pntB 1078098 pntB Shigella flexneri 2a str. 2457T pyridine nucleotide transhydrogenase NP_837287.1 1689247 R 198215 CDS NP_837288.1 30063117 1078099 complement(1690646..1692193) 1 NC_004741.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1692193 pntA 1078099 pntA Shigella flexneri 2a str. 2457T NAD(P) transhydrogenase subunit alpha NP_837288.1 1690646 R 198215 CDS NP_837289.1 30063118 1078132 1692702..1693646 1 NC_004741.1 residues 1 to 314 of 314 are 88.53 pct identical to residues 1 to 314 of 314 from Escherichia coli K-12 : B1604; hypothetical protein 1693646 1078132 S1757 Shigella flexneri 2a str. 2457T hypothetical protein NP_837289.1 1692702 D 198215 CDS NP_837290.1 30063119 1078100 1693832..1695214 1 NC_004741.1 residues 1 to 460 of 460 are 95.86 pct identical to residues 1 to 460 of 460 from Escherichia coli K-12 : B1605; arginine/ornithine antiporter 1695214 1078100 S1758 Shigella flexneri 2a str. 2457T arginine/ornithine antiporter NP_837290.1 1693832 D 198215 CDS NP_837291.1 30063120 1078448 1695251..1695973 1 NC_004741.1 residues 1 to 240 of 240 are 92.50 pct identical to residues 1 to 240 of 240 from Escherichia coli K-12 : B1606; short chain dehydrogenase 1695973 ydgB 1078448 ydgB Shigella flexneri 2a str. 2457T short chain dehydrogenase NP_837291.1 1695251 D 198215 CDS NP_837292.1 30063121 1078101 complement(1695970..1696305) 1 NC_004741.1 residues 23 to 111 of 111 are 100.00 pct identical to residues 23 to 111 of 111 from Escherichia coli K-12 : B1607; hypothetical protein 1696305 ydgC 1078101 ydgC Shigella flexneri 2a str. 2457T hypothetical protein NP_837292.1 1695970 R 198215 CDS NP_837293.1 30063122 1077974 1696434..1697177 1 NC_004741.1 response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1697177 rstA 1077974 rstA Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator RstA NP_837293.1 1696434 D 198215 CDS NP_837294.1 30063123 1078102 1697675..1698721 1 NC_004741.1 residues 1 to 345 of 348 are 70.43 pct identical to residues 100 to 444 of 448 from GenPept : >emb|CAD01997.1| (AL627271) transporter [Salmonella enterica subsp. enterica serovar Typhi]; transporter 1698721 1078102 S1762 Shigella flexneri 2a str. 2457T transporter NP_837294.1 1697675 D 198215 CDS NP_837295.1 30063124 1078026 1698900..1700201 1 NC_004741.1 residues 1 to 433 of 433 are 95.61 pct identical to residues 1 to 433 of 433 from Escherichia coli K-12 : B1609; sensor protein RstB 1700201 rstB 1078026 rstB Shigella flexneri 2a str. 2457T sensor protein RstB NP_837295.1 1698900 D 198215 CDS NP_837296.1 30063125 1079681 1700277..1701206 1 NC_004741.1 binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1701206 tus 1079681 tus Shigella flexneri 2a str. 2457T DNA replication terminus site-binding protein NP_837296.1 1700277 D 198215 CDS NP_837297.1 30063126 1078103 complement(1701203..1702606) 1 NC_004741.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1702606 fumC 1078103 fumC Shigella flexneri 2a str. 2457T fumarate hydratase NP_837297.1 1701203 R 198215 CDS NP_837298.1 30063127 1078104 complement(1702749..1704395) 1 NC_004741.1 residues 1 to 548 of 548 are 99.63 pct identical to residues 1 to 548 of 548 from Escherichia coli K-12 : B1612; fumarase A, fumarate hydratase class I; aerobic isozyme 1704395 fumA 1078104 fumA Shigella flexneri 2a str. 2457T fumarase A, fumarate hydratase class I; aerobic isozyme NP_837298.1 1702749 R 198215 CDS NP_837299.1 30063128 1078039 1704594..1705769 1 NC_004741.1 residues 1 to 391 of 391 are 99.48 pct identical to residues 1 to 391 of 391 from Escherichia coli K-12 : B1613; mannose-6-phosphate isomerase 1705769 manA 1078039 manA Shigella flexneri 2a str. 2457T mannose-6-phosphate isomerase NP_837299.1 1704594 D 198215 CDS NP_837300.1 30063129 1078106 1705870..1707345 1 NC_004741.1 residues 1 to 487 of 491 are 93.83 pct identical to residues 1 to 487 of 502 from Escherichia coli K-12 : B1614; hypothetical protein 1707345 ydgA 1078106 ydgA Shigella flexneri 2a str. 2457T hypothetical protein NP_837300.1 1705870 D 198215 CDS NP_837301.2 161486483 1078107 complement(1707605..1708870) 1 NC_004741.1 residues 1 to 415 of 415 are 98.55 pct identical to residues 3 to 417 of 417 from Escherichia coli K-12 : B1615; outer membrane porin protein 1708870 uidC 1078107 uidC Shigella flexneri 2a str. 2457T outer membrane porin protein NP_837301.2 1707605 R 198215 CDS NP_837302.1 30063131 1078109 complement(1709940..1711643) 1 NC_004741.1 residues 1 to 566 of 567 are 99.46 pct identical to residues 1 to 566 of 603 from Escherichia coli K-12 : B1617; beta-D-glucuronidase 1711643 uidA 1078109 uidA Shigella flexneri 2a str. 2457T beta-D-glucuronidase NP_837302.1 1709940 R 198215 CDS NP_837303.1 30063132 1078111 complement(1712031..1712621) 1 NC_004741.1 residues 1 to 196 of 196 are 100.00 pct identical to residues 1 to 196 of 196 from Escherichia coli K-12 : B1618; repressor for uid operon 1712621 uidR 1078111 uidR Shigella flexneri 2a str. 2457T repressor for uid operon NP_837303.1 1712031 R 198215 CDS NP_837304.1 30063133 1078116 complement(1713026..1713529) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1713529 1078116 S1774 Shigella flexneri 2a str. 2457T IS1 orfB NP_837304.1 1713026 R 198215 CDS NP_837305.1 30063134 1078533 complement(1713448..1713723) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1713723 1078533 S1775 Shigella flexneri 2a str. 2457T IS1 orfA NP_837305.1 1713448 R 198215 CDS NP_837306.1 30063135 1078117 complement(1714506..1715534) 1 NC_004741.1 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1715534 malI 1078117 malI Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor MalI NP_837306.1 1714506 R 198215 CDS NP_837307.1 30063136 1080903 1715709..1717301 1 NC_004741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional maltose and glucose-specific PTS system components IICB 1717301 malX 1080903 malX Shigella flexneri 2a str. 2457T bifunctional maltose and glucose-specific PTS system components IICB NP_837307.1 1715709 D 198215 CDS NP_837308.1 30063137 1078118 1717311..1718483 1 NC_004741.1 residues 1 to 390 of 390 are 98.71 pct identical to residues 1 to 390 of 390 from Escherichia coli K-12 : B1622; cystathionine beta-lyase; maltose regulon modulator 1718483 malY 1078118 malY Shigella flexneri 2a str. 2457T cystathionine beta-lyase; maltose regulon modulator NP_837308.1 1717311 D 198215 CDS NP_837309.1 30063138 1078119 1718587..1719588 1 NC_004741.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1719588 add 1078119 add Shigella flexneri 2a str. 2457T adenosine deaminase NP_837309.1 1718587 D 198215 CDS NP_837310.2 161486482 1078198 complement(1719624..1720664) 1 NC_004741.1 residues 1 to 359 of 359 are 94.42 pct identical to residues 1 to 359 of 359 from Escherichia coli K-12 : B1624; oxidoreductase 1720664 1078198 S1781 Shigella flexneri 2a str. 2457T oxidoreductase NP_837310.2 1719624 R 198215 CDS NP_837311.1 30063140 1078120 1721305..1721520 1 NC_004741.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1721520 1078120 S1782 Shigella flexneri 2a str. 2457T oriC-binding nucleoid-associated protein NP_837311.1 1721305 D 198215 CDS NP_837312.1 30063141 1078122 1721606..1722046 1 NC_004741.1 residues 1 to 146 of 146 are 79.45 pct identical to residues 9 to 154 of 154 from Escherichia coli K-12 : B1626; hypothetical protein 1722046 1078122 S1783 Shigella flexneri 2a str. 2457T hypothetical protein NP_837312.1 1721606 D 198215 CDS NP_837313.1 30063142 1078123 1722123..1722704 1 NC_004741.1 residues 1 to 193 of 193 are 92.22 pct identical to residues 1 to 193 of 193 from Escherichia coli K-12 : B1627; Na(+)-translocating NADH-quinone reductase subunit E 1722704 1078123 S1784 Shigella flexneri 2a str. 2457T Na(+)-translocating NADH-quinone reductase subunit E NP_837313.1 1722123 D 198215 CDS NP_837314.1 30063143 1078124 1722704..1723282 1 NC_004741.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1723282 1078124 S1785 Shigella flexneri 2a str. 2457T electron transport complex protein RnfB NP_837314.1 1722704 D 198215 CDS NP_837315.1 30063144 1079775 1723275..1725497 1 NC_004741.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1725497 1079775 S1786 Shigella flexneri 2a str. 2457T electron transport complex protein RnfC NP_837315.1 1723275 D 198215 CDS NP_837316.1 30063145 1078125 1725498..1726556 1 NC_004741.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1726556 rnfD 1078125 rnfD Shigella flexneri 2a str. 2457T electron transport complex protein RnfD NP_837316.1 1725498 D 198215 CDS NP_837317.1 30063146 1079417 1726560..1727180 1 NC_004741.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1727180 1079417 S1788 Shigella flexneri 2a str. 2457T electron transport complex protein RnfG NP_837317.1 1726560 D 198215 CDS NP_837318.1 30063147 1078126 1727184..1727879 1 NC_004741.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 1727879 ydgQ 1078126 ydgQ Shigella flexneri 2a str. 2457T electron transport complex RsxE subunit NP_837318.1 1727184 D 198215 CDS NP_837319.1 30063148 1078128 1727879..1728514 1 NC_004741.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1728514 nth 1078128 nth Shigella flexneri 2a str. 2457T endonuclease III NP_837319.1 1727879 D 198215 CDS NP_837320.1 30063149 1078129 1729125..1730627 1 NC_004741.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 1730627 tppB 1078129 tppB Shigella flexneri 2a str. 2457T tripeptide transporter permease NP_837320.1 1729125 D 198215 CDS NP_837321.1 30063150 1080553 1730733..1731338 1 NC_004741.1 residues 1 to 201 of 201 are 93.03 pct identical to residues 1 to 201 of 201 from Escherichia coli K-12 : B1635; glutathionine S-transferase 1731338 gst 1080553 gst Shigella flexneri 2a str. 2457T glutathionine S-transferase NP_837321.1 1730733 D 198215 CDS NP_837322.1 30063151 1078130 complement(1731382..1732245) 1 NC_004741.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1732245 pdxY 1078130 pdxY Shigella flexneri 2a str. 2457T pyridoxamine kinase NP_837322.1 1731382 R 198215 CDS NP_837323.1 30063152 1078131 complement(1732304..1733578) 1 NC_004741.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1733578 tyrS 1078131 tyrS Shigella flexneri 2a str. 2457T tyrosyl-tRNA synthetase NP_837323.1 1732304 R 198215 CDS NP_837324.1 30063153 1078135 complement(1733707..1734363) 1 NC_004741.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1734363 pdxH 1078135 pdxH Shigella flexneri 2a str. 2457T pyridoxamine 5'-phosphate oxidase NP_837324.1 1733707 R 198215 CDS NP_837325.1 30063154 1078137 complement(1734422..1734670) 1 NC_004741.1 residues 1 to 82 of 82 are 96.34 pct identical to residues 1 to 82 of 82 from Escherichia coli K-12 : B1639; hypothetical protein 1734670 ydhA 1078137 ydhA Shigella flexneri 2a str. 2457T hypothetical protein NP_837325.1 1734422 R 198215 CDS NP_837326.2 161486481 1078140 complement(1734692..1735597) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1735597 1078140 S1797 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_837326.2 1734692 R 198215 CDS NP_837327.2 161486480 1078141 complement(1735555..1735920) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1735920 1078141 S1798 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_837327.2 1735555 R 198215 CDS NP_837328.1 30063157 1078133 complement(1736185..1737294) 1 NC_004741.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1737294 anmK 1078133 anmK Shigella flexneri 2a str. 2457T anhydro-N-acetylmuramic acid kinase NP_837328.1 1736185 R 198215 CDS NP_837329.1 30063158 1078143 1737568..1738035 1 NC_004741.1 residues 1 to 155 of 155 are 65.16 pct identical to residues 1 to 155 of 155 from Escherichia coli K-12 : B1641; outer membrane protein 1738035 slyB 1078143 slyB Shigella flexneri 2a str. 2457T outer membrane protein NP_837329.1 1737568 D 198215 CDS NP_837330.2 161486479 1077305 complement(1738082..1738516) 1 NC_004741.1 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1738516 slyA 1077305 slyA Shigella flexneri 2a str. 2457T transcriptional regulator SlyA NP_837330.2 1738082 R 198215 CDS NP_837331.1 30063160 1078144 1738717..1738953 1 NC_004741.1 residues 1 to 78 of 78 are 84.61 pct identical to residues 1 to 78 of 78 from Escherichia coli K-12 : B1643; hypothetical protein 1738953 1078144 S1802 Shigella flexneri 2a str. 2457T hypothetical protein NP_837331.1 1738717 D 198215 CDS NP_837332.1 30063161 1079324 1738947..1739813 1 NC_004741.1 residues 1 to 288 of 288 are 97.56 pct identical to residues 12 to 299 of 299 from Escherichia coli K-12 : B1644; hypothetical protein 1739813 1079324 S1803 Shigella flexneri 2a str. 2457T hypothetical protein NP_837332.1 1738947 D 198215 CDS NP_837333.1 30063162 1079362 complement(1741826..1742362) 1 NC_004741.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1742362 sodC 1079362 sodC Shigella flexneri 2a str. 2457T superoxide dismutase NP_837333.1 1741826 R 198215 CDS NP_837334.1 30063163 1078146 complement(1742428..1743324) 1 NC_004741.1 residues 1 to 298 of 298 are 93.95 pct identical to residues 1 to 298 of 298 from Escherichia coli K-12 : B1647; hypothetical protein 1743324 1078146 S1806 Shigella flexneri 2a str. 2457T hypothetical protein NP_837334.1 1742428 R 198215 CDS NP_837335.1 30063164 1078180 complement(1743373..1743750) 1 NC_004741.1 residues 1 to 125 of 125 are 100.00 pct identical to residues 1 to 125 of 125 from Escherichia coli K-12 : B1648; hypothetical protein 1743750 1078180 S1808 Shigella flexneri 2a str. 2457T hypothetical protein NP_837335.1 1743373 R 198215 CDS NP_837336.1 30063165 1078148 1743715..1744314 1 NC_004741.1 residues 1 to 199 of 199 are 99.49 pct identical to residues 1 to 199 of 199 from Escherichia coli K-12 : B1649; hypothetical protein 1744314 1078148 S1807 Shigella flexneri 2a str. 2457T hypothetical protein NP_837336.1 1743715 D 198215 CDS NP_837337.1 30063166 1078459 1744351..1745448 1 NC_004741.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1745448 nemA 1078459 nemA Shigella flexneri 2a str. 2457T N-ethylmaleimide reductase NP_837337.1 1744351 D 198215 CDS NP_837338.1 30063167 1078150 1745529..1745936 1 NC_004741.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1745936 gloA 1078150 gloA Shigella flexneri 2a str. 2457T glyoxalase I NP_837338.1 1745529 D 198215 CDS NP_837339.1 30063168 1078069 1746039..1746686 1 NC_004741.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1746686 rnt 1078069 rnt Shigella flexneri 2a str. 2457T ribonuclease T NP_837339.1 1746039 D 198215 CDS NP_837340.1 30063169 1078527 complement(1751281..1752429) 1 NC_004741.1 residues 1 to 382 of 382 are 96.85 pct identical to residues 21 to 402 of 402 from Escherichia coli K-12 : B1432; virulence protein 1752429 1078527 S1813 Shigella flexneri 2a str. 2457T virulence protein NP_837340.1 1751281 R 198215 CDS NP_837341.1 30063170 1078152 complement(1753036..1753383) 1 NC_004741.1 residues 1 to 115 of 115 are 100.00 pct identical to residues 1 to 115 of 115 from Escherichia coli K-12 : B1654; hypothetical protein 1753383 ydhD 1078152 ydhD Shigella flexneri 2a str. 2457T hypothetical protein NP_837341.1 1753036 R 198215 CDS NP_837342.1 30063171 1078154 1753718..1754545 1 NC_004741.1 residues 1 to 275 of 275 are 79.63 pct identical to residues 1 to 271 of 271 from Escherichia coli K-12 : B1655; lipoprotein 1754545 ydhO 1078154 ydhO Shigella flexneri 2a str. 2457T lipoprotein NP_837342.1 1753718 D 198215 CDS NP_837343.1 30063172 1079354 1754673..1755254 1 NC_004741.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1755254 sodB 1079354 sodB Shigella flexneri 2a str. 2457T superoxide dismutase NP_837343.1 1754673 D 198215 CDS NP_837344.1 30063173 1078155 complement(1755400..1756569) 1 NC_004741.1 residues 1 to 389 of 389 are 86.63 pct identical to residues 1 to 389 of 389 from Escherichia coli K-12 : B1657; transporter 1756569 1078155 S1817 Shigella flexneri 2a str. 2457T transporter NP_837344.1 1755400 R 198215 CDS NP_837345.1 30063174 1078157 1757123..1758148 1 NC_004741.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1758148 purR 1078157 purR Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor PurR NP_837345.1 1757123 D 198215 CDS NP_837346.1 30063175 1079785 complement(1758145..1759077) 1 NC_004741.1 residues 1 to 310 of 310 are 99.35 pct identical to residues 1 to 310 of 310 from Escherichia coli K-12 : B1659; DNA-binding transcriptional regulator 1759077 ydhB 1079785 ydhB Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator NP_837346.1 1758145 R 198215 CDS NP_837347.1 30063176 1078158 1759190..1760401 1 NC_004741.1 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1760401 ydhC 1078158 ydhC Shigella flexneri 2a str. 2457T inner membrane transport protein YdhC NP_837347.1 1759190 D 198215 CDS NP_837348.1 30063177 1080927 1760692..1761840 1 NC_004741.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane-fatty-acyl-phospholipid synthase 1761840 cfa 1080927 cfa Shigella flexneri 2a str. 2457T cyclopropane-fatty-acyl-phospholipid synthase NP_837348.1 1760692 D 198215 CDS NP_837349.1 30063178 1078160 complement(1761880..1762521) 1 NC_004741.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1762521 ribE 1078160 ribE Shigella flexneri 2a str. 2457T riboflavin synthase subunit alpha NP_837349.1 1761880 R 198215 CDS NP_837350.1 30063179 1079330 1762736..1764109 1 NC_004741.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1764109 ydhE 1079330 ydhE Shigella flexneri 2a str. 2457T multidrug efflux protein NP_837350.1 1762736 D 198215 CDS NP_837351.1 30063180 1078161 complement(1764150..1765406) 1 NC_004741.1 residues 1 to 418 of 418 are 98.56 pct identical to residues 1 to 418 of 418 from Escherichia coli K-12 : B1664; hypothetical protein 1765406 1078161 S1824 Shigella flexneri 2a str. 2457T hypothetical protein NP_837351.1 1764150 R 198215 CDS NP_837352.1 30063181 1078163 1765979..1766284 1 NC_004741.1 residues 1 to 101 of 101 are 100.00 pct identical to residues 1 to 101 of 101 from Escherichia coli K-12 : B1667; hypothetical protein 1766284 1078163 S1827 Shigella flexneri 2a str. 2457T hypothetical protein NP_837352.1 1765979 D 198215 CDS NP_837353.1 30063182 1078164 complement(1767844..1768656) 1 NC_004741.1 residues 1 to 270 of 270 are 92.96 pct identical to residues 1 to 270 of 270 from Escherichia coli K-12 : B1669; hypothetical protein 1768656 1078164 S1829 Shigella flexneri 2a str. 2457T hypothetical protein NP_837353.1 1767844 R 198215 CDS NP_837354.1 30063183 1078165 complement(1768660..1769445) 1 NC_004741.1 residues 1 to 261 of 261 are 80.45 pct identical to residues 1 to 261 of 261 from Escherichia coli K-12 : B1670; hypothetical protein 1769445 ydhU 1078165 ydhU Shigella flexneri 2a str. 2457T hypothetical protein NP_837354.1 1768660 R 198215 CDS NP_837355.1 30063184 1078166 complement(1769442..1770161) 1 NC_004741.1 residues 1 to 239 of 239 are 98.74 pct identical to residues 1 to 239 of 239 from Escherichia coli K-12 : B1671; oxidoreductase, Fe-S subunit 1770161 1078166 S1831 Shigella flexneri 2a str. 2457T oxidoreductase, Fe-S subunit NP_837355.1 1769442 R 198215 CDS NP_837356.1 30063185 1078172 complement(1770174..1770812) 1 NC_004741.1 residues 1 to 212 of 212 are 87.26 pct identical to residues 4 to 215 of 215 from Escherichia coli K-12 : B1672; hypothetical protein 1770812 1078172 S1832 Shigella flexneri 2a str. 2457T hypothetical protein NP_837356.1 1770174 R 198215 CDS NP_837357.1 30063186 1078173 complement(1772947..1773573) 1 NC_004741.1 residues 1 to 208 of 208 are 91.82 pct identical to residues 1 to 208 of 208 from Escherichia coli K-12 : B1674; hypothetical protein 1773573 1078173 S1834 Shigella flexneri 2a str. 2457T hypothetical protein NP_837357.1 1772947 R 198215 CDS NP_837358.1 30063187 1078168 complement(1774029..1774238) 1 NC_004741.1 residues 1 to 69 of 69 are 100.00 pct identical to residues 1 to 69 of 69 from Escherichia coli K-12 : B1675; hypothetical protein 1774238 1078168 S1835 Shigella flexneri 2a str. 2457T hypothetical protein NP_837358.1 1774029 R 198215 CDS NP_837359.1 30063188 1078169 1774325..1774600 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1774600 1078169 S1836 Shigella flexneri 2a str. 2457T IS1 orfA NP_837359.1 1774325 D 198215 CDS NP_837360.1 30063189 1077564 1774519..1775022 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1775022 1077564 S1837 Shigella flexneri 2a str. 2457T IS1 orfB NP_837360.1 1774519 D 198215 CDS NP_837361.1 30063190 1078170 1775571..1776983 1 NC_004741.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1776983 pykF 1078170 pykF Shigella flexneri 2a str. 2457T pyruvate kinase NP_837361.1 1775571 D 198215 CDS NP_837362.1 30063191 1079288 1777294..1777530 1 NC_004741.1 residues 1 to 78 of 78 are 100.00 pct identical to residues 1 to 78 of 78 from Escherichia coli K-12 : B1677; murein lipoprotein 1777530 lpp 1079288 lpp Shigella flexneri 2a str. 2457T murein lipoprotein NP_837362.1 1777294 D 198215 CDS NP_837363.1 30063192 1078171 complement(1777593..1778597) 1 NC_004741.1 residues 1 to 334 of 334 are 99.70 pct identical to residues 1 to 334 of 334 from Escherichia coli K-12 : B1678; hypothetical protein 1778597 ynhG 1078171 ynhG Shigella flexneri 2a str. 2457T hypothetical protein NP_837363.1 1777593 R 198215 CDS NP_837364.1 30063193 1077573 complement(1778746..1779162) 1 NC_004741.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1779162 ynhA 1077573 ynhA Shigella flexneri 2a str. 2457T cysteine desufuration protein SufE NP_837364.1 1778746 R 198215 CDS NP_837365.1 30063194 1078174 complement(1779175..1780395) 1 NC_004741.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 1780395 1078174 S1842 Shigella flexneri 2a str. 2457T bifunctional cysteine desulfurase/selenocysteine lyase NP_837365.1 1779175 R 198215 CDS NP_837366.1 30063195 1078176 complement(1780392..1781663) 1 NC_004741.1 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD 1781663 ynhC 1078176 ynhC Shigella flexneri 2a str. 2457T cysteine desulfurase activator complex subunit SufD NP_837366.1 1780392 R 198215 CDS NP_837367.1 30063196 1078186 complement(1781638..1782384) 1 NC_004741.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase 1782384 sufC 1078186 sufC Shigella flexneri 2a str. 2457T cysteine desulfurase NP_837367.1 1781638 R 198215 CDS NP_837368.1 30063197 1078177 complement(1782394..1783881) 1 NC_004741.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1783881 ynhE 1078177 ynhE Shigella flexneri 2a str. 2457T cysteine desulfurase activator complex subunit SufB NP_837368.1 1782394 R 198215 CDS NP_837369.1 30063198 1078178 complement(1783890..1784258) 1 NC_004741.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 1784258 sufA 1078178 sufA Shigella flexneri 2a str. 2457T iron-sulfur cluster assembly scaffold protein NP_837369.1 1783890 R 198215 CDS NP_837370.1 30063199 1078179 complement(1784806..1785075) 1 NC_004741.1 residues 1 to 89 of 89 are 100.00 pct identical to residues 1 to 89 of 89 from Escherichia coli K-12 : B1685; hypothetical protein 1785075 1078179 S1847 Shigella flexneri 2a str. 2457T hypothetical protein NP_837370.1 1784806 R 198215 CDS NP_837371.1 30063200 1078181 complement(1785094..1785504) 1 NC_004741.1 residues 1 to 136 of 136 are 99.26 pct identical to residues 1 to 136 of 136 from Escherichia coli K-12 : B1686; hypothetical protein 1785504 1078181 S1848 Shigella flexneri 2a str. 2457T hypothetical protein NP_837371.1 1785094 R 198215 CDS NP_837372.1 30063201 1078426 complement(1785501..1788557) 1 NC_004741.1 residues 1 to 1018 of 1018 are 97.54 pct identical to residues 1 to 1018 of 1018 from Escherichia coli K-12 : B1687; oxidase 1788557 ydiJ 1078426 ydiJ Shigella flexneri 2a str. 2457T oxidase NP_837372.1 1785501 R 198215 CDS NP_837373.1 30063202 1078184 1788946..1790058 1 NC_004741.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; inner membrane protein 1790058 1078184 S1850 Shigella flexneri 2a str. 2457T inner membrane protein NP_837373.1 1788946 D 198215 CDS NP_837374.1 30063203 1078183 1790487..1790843 1 NC_004741.1 residues 1 to 118 of 118 are 98.30 pct identical to residues 10 to 127 of 127 from Escherichia coli K-12 : B1689; hypothetical protein 1790843 1078183 S1851 Shigella flexneri 2a str. 2457T hypothetical protein NP_837374.1 1790487 D 198215 CDS NP_837375.1 30063204 1079788 1791003..1792148 1 NC_004741.1 residues 1 to 381 of 381 are 98.43 pct identical to residues 21 to 404 of 404 from Escherichia coli K-12 : B1690; transport system permease 1792148 1079788 S1852 Shigella flexneri 2a str. 2457T transport system permease NP_837375.1 1791003 D 198215 CDS NP_837376.1 30063205 1078185 1792442..1793602 1 NC_004741.1 residues 1 to 386 of 386 are 91.19 pct identical to residues 38 to 423 of 423 from Escherichia coli K-12 : B1691; amino acid/amine transport protein 1793602 1078185 S1853 Shigella flexneri 2a str. 2457T amino acid/amine transport protein NP_837376.1 1792442 D 198215 CDS NP_837377.1 30063206 1079284 1793614..1794480 1 NC_004741.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1794480 aroE 1079284 aroE Shigella flexneri 2a str. 2457T quinate/shikimate dehydrogenase NP_837377.1 1793614 D 198215 CDS NP_837378.1 30063207 1078189 1794511..1795269 1 NC_004741.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1795269 aroD 1078189 aroD Shigella flexneri 2a str. 2457T 3-dehydroquinate dehydratase NP_837378.1 1794511 D 198215 CDS NP_837379.1 30063208 1078190 complement(1795351..1795854) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1795854 1078190 S1857 Shigella flexneri 2a str. 2457T IS1 orfB NP_837379.1 1795351 R 198215 CDS NP_837380.1 30063209 1078191 complement(1795773..1796048) 1 NC_004741.1 residues 49 to 88 of 88 are 97.50 pct identical to residues 1 to 40 of 100 from GenPept : >gb|AAL72519.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS1 orfA 1796048 1078191 S1856 Shigella flexneri 2a str. 2457T IS1 orfA NP_837380.1 1795773 R 198215 CDS NP_837381.1 30063210 1078263 1797701..1798858 1 NC_004741.1 residues 1 to 385 of 385 are 99.22 pct identical to residues 6 to 390 of 390 from Escherichia coli K-12 : B1497; enzyme 1798858 1078263 S1859 Shigella flexneri 2a str. 2457T enzyme NP_837381.1 1797701 D 198215 CDS NP_837382.1 30063211 1078195 1800872..1803232 1 NC_004741.1 residues 1 to 786 of 786 are 97.97 pct identical to residues 1 to 790 of 790 from Escherichia coli K-12 : B1495; hypothetical protein 1803232 yddB 1078195 yddB Shigella flexneri 2a str. 2457T hypothetical protein NP_837382.1 1800872 D 198215 CDS NP_837383.1 30063212 1078090 complement(1803502..1804005) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1804005 1078090 S1862 Shigella flexneri 2a str. 2457T IS1 orfB NP_837383.1 1803502 R 198215 CDS NP_837384.1 30063213 1078197 complement(1803924..1804199) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1804199 1078197 S1863 Shigella flexneri 2a str. 2457T IS1 orfA NP_837384.1 1803924 R 198215 CDS NP_837385.1 30063214 1080531 1806810..1807085 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1807085 1080531 S1865 Shigella flexneri 2a str. 2457T IS1 orfA NP_837385.1 1806810 D 198215 CDS NP_837386.1 30063215 1078663 1807004..1807507 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1807507 1078663 S1866 Shigella flexneri 2a str. 2457T IS1 orfB NP_837386.1 1807004 D 198215 CDS NP_837387.1 30063216 1078199 1807985..1809385 1 NC_004741.1 residues 1 to 466 of 466 are 100.00 pct identical to residues 1 to 466 of 466 from Escherichia coli K-12 : B1493; glutamate decarboxylase 1809385 gadB 1078199 gadB Shigella flexneri 2a str. 2457T glutamate decarboxylase NP_837387.1 1807985 D 198215 CDS NP_837388.1 30063217 1078202 1809541..1811076 1 NC_004741.1 residues 1 to 511 of 511 are 87.27 pct identical to residues 1 to 511 of 511 from Escherichia coli K-12 : B1492; acid sensitivity protein, transporter 1811076 xasA 1078202 xasA Shigella flexneri 2a str. 2457T acid sensitivity protein, transporter NP_837388.1 1809541 D 198215 CDS NP_837389.1 30063218 1079979 1811207..1812526 1 NC_004741.1 residues 1 to 439 of 439 are 100.00 pct identical to residues 1 to 439 of 439 from Escherichia coli K-12 : B1491; hypothetical protein 1812526 1079979 S1869 Shigella flexneri 2a str. 2457T hypothetical protein NP_837389.1 1811207 D 198215 CDS NP_837390.1 30063219 1078205 1815194..1816090 1 NC_004741.1 residues 1 to 298 of 298 are 90.26 pct identical to residues 1 to 298 of 298 from Escherichia coli K-12 : B1485; ATP-dependent peptide transporter membrane subunit 1816090 1078205 S1873 Shigella flexneri 2a str. 2457T ATP-dependent peptide transporter membrane subunit NP_837390.1 1815194 D 198215 CDS NP_837391.1 30063220 1080933 1816087..1817073 1 NC_004741.1 residues 1 to 328 of 328 are 97.86 pct identical to residues 1 to 328 of 328 from Escherichia coli K-12 : B1484; ATP-binding component of a transport system 1817073 1080933 S1874 Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_837391.1 1816087 D 198215 CDS NP_837392.1 30063221 1078207 complement(1818048..1818479) 1 NC_004741.1 residues 1 to 143 of 143 are 100.00 pct identical to residues 1 to 143 of 143 from Escherichia coli K-12 : B1482; osmotically inducible protein 1818479 osmC 1078207 osmC Shigella flexneri 2a str. 2457T osmotically inducible protein NP_837392.1 1818048 R 198215 CDS NP_837393.1 30063222 1078209 complement(1818652..1819155) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1819155 1078209 S1877 Shigella flexneri 2a str. 2457T IS1 orfB NP_837393.1 1818652 R 198215 CDS NP_837394.1 30063223 1078114 complement(1819074..1819349) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1819349 1078114 S1878 Shigella flexneri 2a str. 2457T IS1 orfA NP_837394.1 1819074 R 198215 CDS NP_837395.1 30063224 1078212 1819537..1821234 1 NC_004741.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1821234 sfcA 1078212 sfcA Shigella flexneri 2a str. 2457T malate dehydrogenase NP_837395.1 1819537 D 198215 CDS NP_837396.1 30063225 1078211 1821368..1822378 1 NC_004741.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 1822378 adhP 1078211 adhP Shigella flexneri 2a str. 2457T alcohol dehydrogenase NP_837396.1 1821368 D 198215 CDS NP_837397.1 30063226 1078217 1822446..1822808 1 NC_004741.1 residues 1 to 120 of 120 are 89.99 pct identical to residues 1 to 120 of 120 from Escherichia coli K-12 : B1477; hypothetical protein 1822808 yddM 1078217 yddM Shigella flexneri 2a str. 2457T hypothetical protein NP_837397.1 1822446 D 198215 CDS NP_837398.1 30063227 1078218 complement(1823036..1823689) 1 NC_004741.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1823689 fdnI 1078218 fdnI Shigella flexneri 2a str. 2457T formate dehydrogenase-N subunit gamma NP_837398.1 1823036 R 198215 CDS NP_837399.1 30063228 1078136 complement(1823682..1824566) 1 NC_004741.1 residues 1 to 283 of 294 are 100.00 pct identical to residues 1 to 283 of 294 from Escherichia coli K-12 : B1475; formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit 1824566 fdnH 1078136 fdnH Shigella flexneri 2a str. 2457T formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit NP_837399.1 1823682 R 198215 CDS NP_837400.1 30063229 1078219 complement(1824579..1827626) 1 NC_004741.1 residues 1 to 1015 of 1015 are 99.21 pct identical to residues 1 to 1015 of 1015 from Escherichia coli K-12 : B1474; selenocysteine; formate dehydrogenase-N, nitrate-inducible, alpha subunit 1827626 fdnG 1078219 fdnG Shigella flexneri 2a str. 2457T formate dehydrogenase-N, nitrate-inducible, alpha subunit NP_837400.1 1824579 R 198215 CDS NP_837401.1 30063230 1078220 1827858..1828739 1 NC_004741.1 residues 1 to 293 of 293 are 90.78 pct identical to residues 1 to 293 of 293 from Escherichia coli K-12 : B1473; hypothetical protein 1828739 yddG 1078220 yddG Shigella flexneri 2a str. 2457T hypothetical protein NP_837401.1 1827858 D 198215 CDS NP_837402.1 30063231 1078088 1828994..1830094 1 NC_004741.1 residues 1 to 93 of 364 are 100.00 pct identical to residues 1 to 93 of 96 from Escherichia coli K-12 : B1472; outer membrane porin protein 1830094 1078088 S1887 Shigella flexneri 2a str. 2457T outer membrane porin protein NP_837402.1 1828994 D 198215 CDS NP_837403.1 30063232 1078222 1830853..1831842 1 NC_004741.1 residues 1 to 317 of 329 are 92.42 pct identical to residues 1 to 317 of 318 from Escherichia coli K-12 : B1471; glycoprotein 1831842 1078222 S1888 Shigella flexneri 2a str. 2457T glycoprotein NP_837403.1 1830853 D 198215 CDS NP_837404.1 30063233 1078223 1832130..1832405 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1832405 1078223 S1890 Shigella flexneri 2a str. 2457T IS1 orfA NP_837404.1 1832130 D 198215 CDS NP_837405.1 30063234 1080505 1832324..1832827 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 1832827 1080505 S1891 Shigella flexneri 2a str. 2457T IS1 orfB NP_837405.1 1832324 D 198215 CDS NP_837406.1 30063235 1078224 1833285..1834673 1 NC_004741.1 residues 1 to 462 of 462 are 90.90 pct identical to residues 1 to 462 of 462 from Escherichia coli K-12 : B1469; nitrite extrusion protein 2 1834673 narU 1078224 narU Shigella flexneri 2a str. 2457T nitrite extrusion protein 2 NP_837406.1 1833285 D 198215 CDS NP_837407.1 30063236 1078226 1839823..1841043 1 NC_004741.1 residues 1 to 406 of 406 are 98.02 pct identical to residues 1 to 406 of 406 from GenPept : >gb|AAK85176.1| (AF294823) transposase [Shigella sonnei]; partial; IS91 orf 1841043 1078226 S1896 Shigella flexneri 2a str. 2457T IS91 orf NP_837407.1 1839823 D 198215 CDS NP_837408.1 30063237 1078227 complement(1841282..1842004) 1 NC_004741.1 residues 1 to 240 of 240 are 90.83 pct identical to residues 1 to 240 of 240 from Escherichia coli K-12 : B1450; DNA-binding transcriptional regulator 1842004 1078227 S1897 Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator NP_837408.1 1841282 R 198215 CDS NP_837409.1 30063238 1077096 complement(1842145..1843275) 1 NC_004741.1 residues 1 to 376 of 376 are 98.93 pct identical to residues 1 to 376 of 376 from Escherichia coli K-12 : B1449; oxidoreductase 1843275 yncB 1077096 yncB Shigella flexneri 2a str. 2457T oxidoreductase NP_837409.1 1842145 R 198215 CDS NP_837410.2 161486478 1078228 complement(1843312..1844217) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1844217 1078228 S1899 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_837410.2 1843312 R 198215 CDS NP_837411.2 161486477 1078230 complement(1844175..1844540) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1844540 1078230 S1900 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_837411.2 1844175 R 198215 CDS NP_837412.1 30063241 1078232 1844699..1845217 1 NC_004741.1 residues 1 to 172 of 172 are 91.27 pct identical to residues 1 to 172 of 172 from Escherichia coli K-12 : B1448; resistance protein 1845217 1078232 S1901 Shigella flexneri 2a str. 2457T resistance protein NP_837412.1 1844699 D 198215 CDS NP_837413.1 30063242 1080576 1845214..1845663 1 NC_004741.1 residues 1 to 149 of 149 are 98.65 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B1447; hypothetical protein 1845663 1080576 S1902 Shigella flexneri 2a str. 2457T hypothetical protein NP_837413.1 1845214 D 198215 CDS NP_837414.1 30063243 1078233 complement(1845664..1845897) 1 NC_004741.1 residues 1 to 77 of 77 are 100.00 pct identical to residues 1 to 77 of 77 from Escherichia coli K-12 : B1446; hypothetical protein 1845897 1078233 S1903 Shigella flexneri 2a str. 2457T hypothetical protein NP_837414.1 1845664 R 198215 CDS NP_837415.1 30063244 1078235 complement(1845983..1846231) 1 NC_004741.1 residues 1 to 82 of 82 are 96.34 pct identical to residues 1 to 82 of 82 from Escherichia coli K-12 : B1445; hypothetical protein 1846231 1078235 S1904 Shigella flexneri 2a str. 2457T hypothetical protein NP_837415.1 1845983 R 198215 CDS NP_837416.1 30063245 1078236 complement(1847867..1849291) 1 NC_004741.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1849291 1078236 S1905 Shigella flexneri 2a str. 2457T gamma-aminobutyraldehyde dehydrogenase NP_837416.1 1847867 R 198215 CDS NP_837417.1 30063246 1078239 complement(1849313..1850107) 1 NC_004741.1 residues 1 to 264 of 264 are 74.24 pct identical to residues 1 to 264 of 264 from Escherichia coli K-12 : B1443; transport system permease 1850107 1078239 S1906 Shigella flexneri 2a str. 2457T transport system permease NP_837417.1 1849313 R 198215 CDS NP_837418.1 30063247 1078242 1850946..1851560 1 NC_004741.1 residues 1 to 199 of 204 are 98.49 pct identical to residues 1 to 199 of 406 from GenPept : >gb|AAK85176.1| (AF294823) transposase [Shigella sonnei]; partial; IS1294 transposase 1851560 1078242 S1908 Shigella flexneri 2a str. 2457T IS1294 transposase NP_837418.1 1850946 D 198215 CDS NP_837419.1 30063248 1078676 1851560..1852006 1 NC_004741.1 residues 1 to 148 of 148 are 83.33 pct identical to residues 19 to 168 of 168 from GenPept : >dbj|BAA84868.1| (AB024946) orf33 [Escherichia coli]; IS1294 transposase 1852006 1078676 S1909 Shigella flexneri 2a str. 2457T IS1294 transposase NP_837419.1 1851560 D 198215 CDS NP_837420.1 30063249 1078038 complement(1852484..1852690) 1 NC_004741.1 residues 1 to 68 of 68 are 100.00 pct identical to residues 30 to 97 of 97 from GenPept : >gb|AAL72510.1| (AF386526) transposase tnpC-like protein [Shigella flexneri 2a]; partial; IS629 orfB 1852690 1078038 S1910 Shigella flexneri 2a str. 2457T IS629 orfB NP_837420.1 1852484 R 198215 CDS NP_837421.1 30063250 1078245 complement(1852746..1853105) 1 NC_004741.1 residues 1 to 119 of 119 are 100.00 pct identical to residues 17 to 135 of 135 from GenPept : >gb|AAL72509.1| (AF386526) transposase-like protein [Shigella flexneri 2a]; partial; IS629 orfB 1853105 1078245 S1911 Shigella flexneri 2a str. 2457T IS629 orfB NP_837421.1 1852746 R 198215 CDS NP_837422.1 30063251 1078246 complement(1853368..1853694) 1 NC_004741.1 residues 1 to 108 of 108 are 70.37 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72412.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA 1853694 1078246 S1912 Shigella flexneri 2a str. 2457T IS629 orfA NP_837422.1 1853368 R 198215 CDS NP_837423.1 30063252 1078247 complement(1856431..1856772) 1 NC_004741.1 residues 1 to 113 of 113 are 86.72 pct identical to residues 1 to 113 of 113 from Escherichia coli K-12 : B1839; hypothetical protein 1856772 1078247 S1915 Shigella flexneri 2a str. 2457T hypothetical protein NP_837423.1 1856431 R 198215 CDS NP_837424.1 30063253 1079924 complement(1857661..1858035) 1 NC_004741.1 residues 1 to 124 of 124 are 89.51 pct identical to residues 1 to 124 of 124 from Escherichia coli K-12 : B1841; hypothetical protein 1858035 1079924 S1917 Shigella flexneri 2a str. 2457T hypothetical protein NP_837424.1 1857661 R 198215 CDS NP_837425.1 30063254 1078156 1858174..1858404 1 NC_004741.1 residues 1 to 76 of 76 are 100.00 pct identical to residues 1 to 76 of 76 from Escherichia coli K-12 : B1842; DNA polymerase III subunit theta 1858404 holE 1078156 holE Shigella flexneri 2a str. 2457T DNA polymerase III subunit theta NP_837425.1 1858174 D 198215 CDS NP_837426.1 30063255 1078252 1858737..1859162 1 NC_004741.1 residues 1 to 141 of 141 are 99.29 pct identical to residues 78 to 218 of 218 from Escherichia coli K-12 : B1843; hypothetical protein 1859162 1078252 S1919 Shigella flexneri 2a str. 2457T hypothetical protein NP_837426.1 1858737 D 198215 CDS NP_837427.1 30063256 1078253 1859186..1859848 1 NC_004741.1 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1859848 1078253 S1920 Shigella flexneri 2a str. 2457T exodeoxyribonuclease X NP_837427.1 1859186 D 198215 CDS NP_837428.1 30063257 1078255 complement(1859845..1861905) 1 NC_004741.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 1861905 ptrB 1078255 ptrB Shigella flexneri 2a str. 2457T protease 2 NP_837428.1 1859845 R 198215 CDS NP_837429.1 30063258 1076941 complement(1862115..1862774) 1 NC_004741.1 residues 1 to 219 of 219 are 72.60 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B1846; hypothetical protein 1862774 yebE 1076941 yebE Shigella flexneri 2a str. 2457T hypothetical protein NP_837429.1 1862115 R 198215 CDS NP_837430.1 30063259 1078256 complement(1863101..1863457) 1 NC_004741.1 secreted protein; unknown function; hypothetical protein 1863457 yebF 1078256 yebF Shigella flexneri 2a str. 2457T hypothetical protein NP_837430.1 1863101 R 198215 CDS NP_837431.1 30063260 1078096 1863948..1865126 1 NC_004741.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 1865126 purT 1078096 purT Shigella flexneri 2a str. 2457T phosphoribosylglycinamide formyltransferase 2 NP_837431.1 1863948 D 198215 CDS NP_837432.1 30063261 1078259 complement(1865182..1865823) 1 NC_004741.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1865823 eda 1078259 eda Shigella flexneri 2a str. 2457T keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase NP_837432.1 1865182 R 198215 CDS NP_837433.1 30063262 1078258 complement(1865860..1867671) 1 NC_004741.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1867671 edd 1078258 edd Shigella flexneri 2a str. 2457T phosphogluconate dehydratase NP_837433.1 1865860 R 198215 CDS NP_837434.1 30063263 1078260 complement(1867906..1869381) 1 NC_004741.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1869381 zwf 1078260 zwf Shigella flexneri 2a str. 2457T glucose-6-phosphate 1-dehydrogenase NP_837434.1 1867906 R 198215 CDS NP_837435.1 30063264 1080143 1869719..1870540 1 NC_004741.1 Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 1870540 yebK 1080143 yebK Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator HexR NP_837435.1 1869719 D 198215 CDS NP_837436.1 30063265 1078261 1870718..1872160 1 NC_004741.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1872160 pykA 1078261 pykA Shigella flexneri 2a str. 2457T pyruvate kinase NP_837436.1 1870718 D 198215 CDS NP_837437.1 30063266 1078262 complement(1872291..1873262) 1 NC_004741.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 1873262 msbB 1078262 msbB Shigella flexneri 2a str. 2457T lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase NP_837437.1 1872291 R 198215 CDS NP_837438.1 30063267 1079644 complement(1873382..1874704) 1 NC_004741.1 residues 22 to 440 of 440 are 100.00 pct identical to residues 1 to 419 of 419 from Escherichia coli K-12 : B1856; hypothetical protein 1874704 yebA 1079644 yebA Shigella flexneri 2a str. 2457T hypothetical protein NP_837438.1 1873382 R 198215 CDS NP_837439.2 161486476 1078264 complement(1874720..1875652) 1 NC_004741.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component 1875652 znuA 1078264 znuA Shigella flexneri 2a str. 2457T high-affinity zinc transporter periplasmic component NP_837439.2 1874720 R 198215 CDS NP_837440.1 30063269 1078265 1875731..1876486 1 NC_004741.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 1876486 znuC 1078265 znuC Shigella flexneri 2a str. 2457T high-affinity zinc transporter ATPase NP_837440.1 1875731 D 198215 CDS NP_837441.1 30063270 1078266 1876483..1877268 1 NC_004741.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component 1877268 znuB 1078266 znuB Shigella flexneri 2a str. 2457T high-affinity zinc transporter membrane component NP_837441.1 1876483 D 198215 CDS NP_837442.1 30063271 1078268 complement(1877415..1878425) 1 NC_004741.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1878425 ruvB 1078268 ruvB Shigella flexneri 2a str. 2457T Holliday junction DNA helicase RuvB NP_837442.1 1877415 R 198215 CDS NP_837443.1 30063272 1077912 complement(1878434..1879045) 1 NC_004741.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1879045 ruvA 1077912 ruvA Shigella flexneri 2a str. 2457T Holliday junction DNA helicase RuvA NP_837443.1 1878434 R 198215 CDS NP_837444.1 30063273 1078270 complement(1879923..1880444) 1 NC_004741.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1880444 ruvC 1078270 ruvC Shigella flexneri 2a str. 2457T Holliday junction resolvase NP_837444.1 1879923 R 198215 CDS NP_837445.1 30063274 1078271 complement(1880479..1881219) 1 NC_004741.1 residues 1 to 246 of 246 are 100.00 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B1864; hypothetical protein 1881219 yebC 1078271 yebC Shigella flexneri 2a str. 2457T hypothetical protein NP_837445.1 1880479 R 198215 CDS NP_837446.1 30063275 1078272 complement(1881248..1881730) 1 NC_004741.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 1881730 ntpA 1078272 ntpA Shigella flexneri 2a str. 2457T dATP pyrophosphohydrolase NP_837446.1 1881248 R 198215 CDS NP_837447.1 30063276 1078274 complement(1881818..1883590) 1 NC_004741.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1883590 aspS 1078274 aspS Shigella flexneri 2a str. 2457T aspartyl-tRNA synthetase NP_837447.1 1881818 R 198215 CDS NP_837448.1 30063277 1078276 1884346..1885542 1 NC_004741.1 residues 1 to 398 of 398 are 91.45 pct identical to residues 1 to 398 of 398 from GenPept : >gb|AAL72391.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl4 orf 1885542 1078276 S1944 Shigella flexneri 2a str. 2457T ISSfl4 orf NP_837448.1 1884346 D 198215 CDS NP_837449.1 30063278 1078278 1886271..1886519 1 NC_004741.1 residues 1 to 82 of 82 are 96.34 pct identical to residues 1 to 82 of 82 from GenPept : >gb|AAG57731.1|AE005491_11 (AE005491) Z3916 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 1886519 1078278 S1946 Shigella flexneri 2a str. 2457T hypothetical protein NP_837449.1 1886271 D 198215 CDS NP_837450.1 30063279 1078279 1887119..1888870 1 NC_004741.1 residues 1 to 583 of 583 are 99.82 pct identical to residues 1 to 583 of 583 from NRprotein_Feb03 : >ref|NP_707728.1| IpaH9.8 [Shigella flexneri 2a str. 301] gb|AAN43435.1|AE015207_3 IpaH9.8 [Shigella flexneri 2a str. 301]; invasion plasmid antigen 1888870 ipaH_4 1078279 ipaH_4 Shigella flexneri 2a str. 2457T invasion plasmid antigen NP_837450.1 1887119 D 198215 CDS NP_837451.1 30063280 1080555 complement(1888871..1889050) 1 NC_004741.1 no significant similarities; hypothetical protein 1889050 1080555 S1948 Shigella flexneri 2a str. 2457T hypothetical protein NP_837451.1 1888871 R 198215 CDS NP_837452.1 30063281 1078280 complement(1889050..1889673) 1 NC_004741.1 residues 21 to 207 of 207 are 68.44 pct identical to residues 2 to 188 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein 1889673 1078280 S1949 Shigella flexneri 2a str. 2457T hypothetical protein NP_837452.1 1889050 R 198215 CDS NP_837453.1 30063282 1078281 1891397..1891939 1 NC_004741.1 residues 1 to 180 of 180 are 70.55 pct identical to residues 1 to 179 of 179 from GenPept : >emb|CAA80648.1| (Z23101) Sequence similarity to P4 ORF199 suggests ORF179 expression [Shigella flexneri]; hypothetical protein 1891939 1078281 S1950 Shigella flexneri 2a str. 2457T hypothetical protein NP_837453.1 1891397 D 198215 CDS NP_837454.1 30063283 1078282 1892281..1892691 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1892691 1078282 S1952 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_837454.1 1892281 D 198215 CDS NP_837455.2 161486475 1078283 1892649..1893554 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1893554 1078283 S1953 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_837455.2 1892649 D 198215 CDS NP_837456.1 30063285 1079737 1894097..1894372 1 NC_004741.1 Rac prophage hypothetical protein; hypothetical protein 1894372 1079737 S1954 Shigella flexneri 2a str. 2457T hypothetical protein NP_837456.1 1894097 D 198215 CDS NP_837457.1 30063286 1078284 1894472..1895896 1 NC_004741.1 residues 1 to 474 of 474 are 96.20 pct identical to residues 1 to 474 of 1042 from GenPept : >emb|CAD05617.1| (AL627272) exodeoxyribonuclease VIII [Salmonella enterica subsp. enterica serovar Typhi]; exodeoxyribonuclease VIII 1895896 1078284 S1955 Shigella flexneri 2a str. 2457T exodeoxyribonuclease VIII NP_837457.1 1894472 D 198215 CDS NP_837458.1 30063287 1078287 1897139..1897459 1 NC_004741.1 residues 10 to 105 of 106 are 83.33 pct identical to residues 2 to 97 of 98 from GenPept : >dbj|BAB87956.1| (AP004402) Gam protein [Stx2 converting bacteriophage I]; host-nuclease inhibitor protein Gam 1897459 1078287 S1957 Shigella flexneri 2a str. 2457T host-nuclease inhibitor protein Gam NP_837458.1 1897139 D 198215 CDS NP_837459.1 30063288 1078288 1897519..1898562 1 NC_004741.1 residues 1 to 181 of 347 are 28.27 pct identical to residues 15 to 188 of 340 from GenPept : >gb|AAK94416.1|AF396866_81 (AF396866) p81 [Bacteriophage Mx8]; bacteriophage protein 1898562 1078288 S1958 Shigella flexneri 2a str. 2457T bacteriophage protein NP_837459.1 1897519 D 198215 CDS NP_837460.1 30063289 1078290 1898637..1898963 1 NC_004741.1 residues 1 to 108 of 108 are 74.07 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAF09023.1| (AF139596) unknown [Shigella flexneri]; IS629 orfA 1898963 1078290 S1959 Shigella flexneri 2a str. 2457T IS629 orfA NP_837460.1 1898637 D 198215 CDS NP_837461.1 30063290 1078291 1899199..1899846 1 NC_004741.1 residues 1 to 215 of 215 are 99.06 pct identical to residues 8 to 222 of 222 from GenPept : >gb|AAL72361.1| (AF386526) transposase [Shigella flexneri 2a]; partial; IS629 orfB 1899846 1078291 S1960 Shigella flexneri 2a str. 2457T IS629 orfB NP_837461.1 1899199 D 198215 CDS NP_837462.1 30063291 1078292 complement(1900250..1900753) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1900753 1078292 S1961 Shigella flexneri 2a str. 2457T IS1 orfB NP_837462.1 1900250 R 198215 CDS NP_837463.1 30063292 1078293 complement(1900672..1900947) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1900947 1078293 S1962 Shigella flexneri 2a str. 2457T IS1 orfA NP_837463.1 1900672 R 198215 CDS NP_837464.1 30063293 1078294 1901037..1901642 1 NC_004741.1 residues 1 to 201 of 201 are 97.51 pct identical to residues 211 to 411 of 411 from GenPept : >gb|AAG56452.1|AE005371_8 (AE005371) integrase for prophage CP-933R [Escherichia coli O157:H7 EDL933]; integrase for prophage CP-933R 1901642 1078294 S1963 Shigella flexneri 2a str. 2457T integrase for prophage CP-933R NP_837464.1 1901037 D 198215 CDS NP_837465.1 30063294 1078295 1902098..1902988 1 NC_004741.1 residues 16 to 296 of 296 are 79.35 pct identical to residues 24 to 304 of 305 from GenPept : >gb|AAL21741.1| (AE008830) Salmonella iron transporter: fur regulated [Salmonella typhimurium LT2]; Iron transport protein 1902988 sitA 1078295 sitA Shigella flexneri 2a str. 2457T Iron transport protein NP_837465.1 1902098 D 198215 CDS NP_837466.1 30063295 1078296 1902988..1903815 1 NC_004741.1 residues 2 to 266 of 275 are 77.73 pct identical to residues 1 to 265 of 273 from GenPept : >emb|CAD05969.1| (AL627276) Iron transport protein, ATP-binding component [Salmonella enterica subsp. enterica serovar Typhi]; Iron transport protein, ATP-binding component 1903815 sitB 1078296 sitB Shigella flexneri 2a str. 2457T Iron transport protein, ATP-binding component NP_837466.1 1902988 D 198215 CDS NP_837467.1 30063296 1078297 1903812..1904669 1 NC_004741.1 residues 1 to 277 of 285 are 75.45 pct identical to residues 1 to 277 of 286 from GenPept : >gb|AAL21743.1| (AE008830) Salmonella iron transporter: fur regulated [Salmonella typhimurium LT2]; Iron transport protein 1904669 sitC 1078297 sitC Shigella flexneri 2a str. 2457T Iron transport protein NP_837467.1 1903812 D 198215 CDS NP_837468.1 30063297 1078298 1904666..1905523 1 NC_004741.1 residues 2 to 263 of 285 are 64.50 pct identical to residues 3 to 264 of 282 from GenPept : >emb|CAD05971.1| (AL627276) Iron transport protein, inner membrane component [Salmonella enterica subsp. enterica serovar Typhi]; Iron transport protein, inner membrane component 1905523 sitD 1078298 sitD Shigella flexneri 2a str. 2457T Iron transport protein, inner membrane component NP_837468.1 1904666 D 198215 CDS NP_837469.1 30063298 1078299 complement(1905724..1906287) 1 NC_004741.1 residues 1 to 187 of 187 are 70.05 pct identical to residues 2 to 188 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein 1906287 1078299 S1968 Shigella flexneri 2a str. 2457T hypothetical protein NP_837469.1 1905724 R 198215 CDS NP_837470.1 30063299 1078300 complement(1906298..1907566) 1 NC_004741.1 residues 1 to 420 of 422 are 37.55 pct identical to residues 1 to 488 of 490 from GenPept : >emb|CAC83574.1| (AJ298298) tail fiber protein [Bacteriophage P27]; tail fiber protein 1907566 1078300 S1969 Shigella flexneri 2a str. 2457T tail fiber protein NP_837470.1 1906298 R 198215 CDS NP_837471.1 30063300 1078301 complement(1907590..1908078) 1 NC_004741.1 residues 9 to 162 of 162 are 75.97 pct identical to residues 29 to 182 of 182 from GenPept : >emb|CAC83573.1| (AJ298298) tail fiber assembly protein [Bacteriophage P27]; tail fiber assembly protein 1908078 1078301 S1970 Shigella flexneri 2a str. 2457T tail fiber assembly protein NP_837471.1 1907590 R 198215 CDS NP_837472.1 30063301 1078302 complement(1908138..1908341) 1 NC_004741.1 residues 5 to 67 of 67 are 58.73 pct identical to residues 497 to 558 of 558 from GenPept : >dbj|BAA00552.1| (D00660) Bcv gene product [Shigella boydii]; hypothetical protein 1908341 1078302 S1971 Shigella flexneri 2a str. 2457T hypothetical protein NP_837472.1 1908138 R 198215 CDS NP_837473.1 30063302 1078303 complement(1908558..1909271) 1 NC_004741.1 residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 1909271 1078303 S1972 Shigella flexneri 2a str. 2457T IS600 orfB NP_837473.1 1908558 R 198215 CDS NP_837474.1 30063303 1080732 complement(1909479..1909688) 1 NC_004741.1 residues 1 to 69 of 69 are 100.00 pct identical to residues 99 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS1 orfB 1909688 1080732 S1973 Shigella flexneri 2a str. 2457T IS1 orfB NP_837474.1 1909479 R 198215 CDS NP_837475.1 30063304 1078304 complement(1909901..1910176) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1910176 1078304 S1975 Shigella flexneri 2a str. 2457T IS1 orfA NP_837475.1 1909901 R 198215 CDS NP_837476.1 30063305 1078305 complement(1910765..1911391) 1 NC_004741.1 residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB 1911391 1078305 S1978 Shigella flexneri 2a str. 2457T IS911 orfB NP_837476.1 1910765 R 198215 CDS NP_837477.1 30063306 1078307 complement(1911631..1911933) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 1911933 1078307 S1980 Shigella flexneri 2a str. 2457T IS911 orfA NP_837477.1 1911631 R 198215 CDS NP_837478.1 30063307 1078308 complement(1912634..1914238) 1 NC_004741.1 residues 15 to 534 of 534 are 74.24 pct identical to residues 7 to 531 of 548 from GenPept : >emb|CAD02867.1| (AL627277) possible integrase [Salmonella enterica subsp. enterica serovar Typhi]; integrase 1914238 1078308 S1981 Shigella flexneri 2a str. 2457T integrase NP_837478.1 1912634 R 198215 CDS NP_837479.1 30063308 1078313 complement(1914839..1915528) 1 NC_004741.1 residues 1 to 229 of 229 are 91.70 pct identical to residues 1 to 229 of 229 from GenPept : >gb|AAK16973.1|AE006460_11 (AE006460) Q antiterminator encoded by prophage CP-933P [Escherichia coli O157:H7 EDL933]; Q antiterminator encoded by prophage CP-933P 1915528 1078313 S1986 Shigella flexneri 2a str. 2457T Q antiterminator encoded by prophage CP-933P NP_837479.1 1914839 R 198215 CDS NP_837480.1 30063309 1078314 complement(1915525..1915884) 1 NC_004741.1 residues 1 to 119 of 119 are 92.43 pct identical to residues 1 to 119 of 119 from GenPept : >gb|AAK16974.1|AE006460_12 (AE006460) endonuclease encoded by cryptic prophage CP-933P [Escherichia coli O157:H7 EDL933]; crossover junction endodeoxyribonuclease 1915884 1078314 S1987 Shigella flexneri 2a str. 2457T crossover junction endodeoxyribonuclease NP_837480.1 1915525 R 198215 CDS NP_837481.1 30063310 1078315 1916531..1917244 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 1917244 1078315 S1989 Shigella flexneri 2a str. 2457T IS600 orfB NP_837481.1 1916531 D 198215 CDS NP_837482.1 30063311 1078187 1917742..1918569 1 NC_004741.1 residues 1 to 275 of 275 are 89.81 pct identical to residues 1 to 275 of 275 from GenPept : >emb|CAC83523.1| (AJ298298) serine protease [Bacteriophage P27]; serine protease 1918569 1078187 S1990 Shigella flexneri 2a str. 2457T serine protease NP_837482.1 1917742 D 198215 CDS NP_837483.1 30063312 1078316 1918613..1919362 1 NC_004741.1 residues 114 to 246 of 249 are 69.92 pct identical to residues 102 to 234 of 235 from GenPept : >emb|CAC83532.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein 1919362 1078316 S1991 Shigella flexneri 2a str. 2457T hypothetical protein NP_837483.1 1918613 D 198215 CDS NP_837484.1 30063313 1078317 1919359..1919928 1 NC_004741.1 no significant similarities; hypothetical protein 1919928 1078317 S1992 Shigella flexneri 2a str. 2457T hypothetical protein NP_837484.1 1919359 D 198215 CDS NP_837485.1 30063314 1078318 1920052..1920294 1 NC_004741.1 residues 1 to 80 of 80 are 85.00 pct identical to residues 1 to 80 of 80 from GenPept : >dbj|BAB36434.1| (AP002560) hypothetical protein [Escherichia coli O157:H7]; hypothetical protein 1920294 1078318 S1994 Shigella flexneri 2a str. 2457T hypothetical protein NP_837485.1 1920052 D 198215 CDS NP_837486.1 30063315 1078254 1920298..1920444 1 NC_004741.1 residues 1 to 44 of 48 are 77.27 pct identical to residues 1 to 44 of 44 from GenPept : >gb|AAG57257.1|AE005444_7 (AE005444) unknown protein encoded within prophage CP-933V [Escherichia coli O157:H7 EDL933]; bacteriophage protein 1920444 1078254 S1995 Shigella flexneri 2a str. 2457T bacteriophage protein NP_837486.1 1920298 D 198215 CDS NP_837487.1 30063316 1078319 complement(1921491..1921793) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 1921793 1078319 S1998 Shigella flexneri 2a str. 2457T IS911 orfA NP_837487.1 1921491 R 198215 CDS NP_837488.1 30063317 1079302 1922426..1922821 1 NC_004741.1 residues 15 to 131 of 131 are 99.14 pct identical to residues 25 to 141 of 141 from Escherichia coli K-12 : B1869; hypothetical protein 1922821 yecN 1079302 yecN Shigella flexneri 2a str. 2457T hypothetical protein NP_837488.1 1922426 D 198215 CDS NP_837489.1 30063318 1078321 1922862..1923605 1 NC_004741.1 residues 1 to 247 of 247 are 99.59 pct identical to residues 1 to 247 of 247 from Escherichia coli K-12 : B1870; hypothetical protein 1923605 yecO 1078321 yecO Shigella flexneri 2a str. 2457T hypothetical protein NP_837489.1 1922862 D 198215 CDS NP_837490.1 30063319 1078322 1923602..1924573 1 NC_004741.1 residues 1 to 323 of 323 are 98.14 pct identical to residues 1 to 323 of 323 from Escherichia coli K-12 : B1871; enzyme 1924573 yecP 1078322 yecP Shigella flexneri 2a str. 2457T enzyme NP_837490.1 1923602 D 198215 CDS NP_837491.1 30063320 1078324 complement(1924738..1927167) 1 NC_004741.1 residues 1 to 809 of 809 are 96.04 pct identical to residues 7 to 815 of 815 from Escherichia coli K-12 : B1872; biotin sulfoxide reductase 1927167 bisZ 1078324 bisZ Shigella flexneri 2a str. 2457T biotin sulfoxide reductase NP_837491.1 1924738 R 198215 CDS NP_837492.1 30063321 1078325 complement(1927192..1928292) 1 NC_004741.1 residues 1 to 366 of 366 are 92.07 pct identical to residues 1 to 366 of 366 from Escherichia coli K-12 : B1873; cytochrome C-type protein 1928292 yecK 1078325 yecK Shigella flexneri 2a str. 2457T cytochrome C-type protein NP_837492.1 1927192 R 198215 CDS NP_837493.1 30063322 1078326 complement(1928680..1929120) 1 NC_004741.1 residues 1 to 146 of 146 are 100.00 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 : B1874; copper homeostasis protein 1929120 cutC 1078326 cutC Shigella flexneri 2a str. 2457T copper homeostasis protein NP_837493.1 1928680 R 198215 CDS NP_837494.1 30063323 1078327 complement(1929440..1930006) 1 NC_004741.1 residues 1 to 188 of 188 are 97.34 pct identical to residues 3 to 190 of 190 from Escherichia coli K-12 : B1875; hypothetical protein 1930006 yecM 1078327 yecM Shigella flexneri 2a str. 2457T hypothetical protein NP_837494.1 1929440 R 198215 CDS NP_837495.1 30063324 1078328 1930222..1931955 1 NC_004741.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1931955 argS 1078328 argS Shigella flexneri 2a str. 2457T arginyl-tRNA synthetase NP_837495.1 1930222 D 198215 CDS NP_837496.1 30063325 1078330 complement(1932840..1933274) 1 NC_004741.1 residues 16 to 144 of 144 are 99.22 pct identical to residues 94 to 222 of 222 from GenPept : >gb|AAL72362.1| (AF386526) transposase [Shigella flexneri 2a]; partial; IS629 orfB 1933274 1078330 S2009 Shigella flexneri 2a str. 2457T IS629 orfB NP_837496.1 1932840 R 198215 CDS NP_837497.1 30063326 1078331 complement(1933709..1934035) 1 NC_004741.1 residues 1 to 108 of 108 are 80.55 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72409.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA 1934035 1078331 S2011 Shigella flexneri 2a str. 2457T IS629 orfA NP_837497.1 1933709 R 198215 CDS NP_837498.1 30063327 1078332 complement(1934087..1934425) 1 NC_004741.1 residues 1 to 112 of 112 are 98.21 pct identical to residues 1 to 112 of 130 from Escherichia coli K-12 : B1878; flagellar protein 1934425 flhE 1078332 flhE Shigella flexneri 2a str. 2457T flagellar protein NP_837498.1 1934087 R 198215 CDS NP_837499.1 30063328 1078334 complement(1936449..1937642) 1 NC_004741.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 1937642 flhB 1078334 flhB Shigella flexneri 2a str. 2457T flagellar biosynthesis protein FlhB NP_837499.1 1936449 R 198215 CDS NP_837500.1 30063329 1078335 1937878..1938336 1 NC_004741.1 residues 1 to 128 of 152 are 40.90 pct identical to residues 1 to 122 of 465 from GenPept : >emb|CAD00870.1| (AL591984) similar to dGTP triphosphohydrolase [Listeria monocytogenes]; hypothetical protein 1938336 1078335 S2015 Shigella flexneri 2a str. 2457T hypothetical protein NP_837500.1 1937878 D 198215 CDS NP_837501.1 30063330 1078336 complement(1939126..1939428) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 1939428 1078336 S2018 Shigella flexneri 2a str. 2457T IS911 orfA NP_837501.1 1939126 R 198215 CDS NP_837502.1 30063331 1078337 1939569..1939964 1 NC_004741.1 hypothetical protein 1939964 1078337 S2019 Shigella flexneri 2a str. 2457T hypothetical protein NP_837502.1 1939569 D 198215 CDS NP_837503.1 30063332 1078339 1940459..1941172 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 1941172 1078339 S2020 Shigella flexneri 2a str. 2457T IS600 orfB NP_837503.1 1940459 D 198215 CDS NP_837504.1 30063333 1078341 complement(1941677..1942321) 1 NC_004741.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 1942321 cheZ 1078341 cheZ Shigella flexneri 2a str. 2457T chemotaxis regulator CheZ NP_837504.1 1941677 R 198215 CDS NP_837505.1 30063334 1078342 complement(1942332..1942721) 1 NC_004741.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 1942721 cheY 1078342 cheY Shigella flexneri 2a str. 2457T chemotaxis regulatory protein CheY NP_837505.1 1942332 R 198215 CDS NP_837506.1 30063335 1078343 complement(1942736..1943785) 1 NC_004741.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 1943785 cheB 1078343 cheB Shigella flexneri 2a str. 2457T chemotaxis-specific methylesterase NP_837506.1 1942736 R 198215 CDS NP_837507.1 30063336 1078344 complement(1943788..1944648) 1 NC_004741.1 methylates the MCP; chemotaxis methyltransferase CheR 1944648 cheR 1078344 cheR Shigella flexneri 2a str. 2457T chemotaxis methyltransferase CheR NP_837507.1 1943788 R 198215 CDS NP_837508.1 30063337 1078345 complement(1944667..1946268) 1 NC_004741.1 mediates taxis toward dipeptides; methyl-accepting protein IV 1946268 tap 1078345 tap Shigella flexneri 2a str. 2457T methyl-accepting protein IV NP_837508.1 1944667 R 198215 CDS NP_837509.1 30063338 1078346 complement(1946314..1947975) 1 NC_004741.1 residues 1 to 553 of 553 are 83.18 pct identical to residues 1 to 553 of 553 from Escherichia coli K-12 : B1886; methyl-accepting chemotaxis protein II, aspartate sensor receptor 1947975 tar 1078346 tar Shigella flexneri 2a str. 2457T methyl-accepting chemotaxis protein II, aspartate sensor receptor NP_837509.1 1946314 R 198215 CDS NP_837510.1 30063339 1078347 complement(1948120..1948623) 1 NC_004741.1 residues 1 to 167 of 167 are 91.01 pct identical to residues 1 to 167 of 167 from Escherichia coli K-12 : B1887; purine-binding chemotaxis protein 1948623 cheW 1078347 cheW Shigella flexneri 2a str. 2457T purine-binding chemotaxis protein NP_837510.1 1948120 R 198215 CDS NP_837511.1 30063340 1078348 complement(1948644..1950608) 1 NC_004741.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 1950608 cheA 1078348 cheA Shigella flexneri 2a str. 2457T chemotaxis protein CheA NP_837511.1 1948644 R 198215 CDS NP_837512.1 30063341 1078576 complement(1950613..1951539) 1 NC_004741.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 1951539 motB 1078576 motB Shigella flexneri 2a str. 2457T flagellar motor protein MotB NP_837512.1 1950613 R 198215 CDS NP_837513.1 30063342 1078349 complement(1951536..1952423) 1 NC_004741.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 1952423 motA 1078349 motA Shigella flexneri 2a str. 2457T flagellar motor protein MotA NP_837513.1 1951536 R 198215 CDS NP_837514.1 30063343 1078350 complement(1952550..1953128) 1 NC_004741.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 1953128 flhC 1078350 flhC Shigella flexneri 2a str. 2457T transcriptional activator FlhC NP_837514.1 1952550 R 198215 CDS NP_837515.1 30063344 1078352 1953391..1953666 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 1953666 1078352 S2033 Shigella flexneri 2a str. 2457T IS1 orfA NP_837515.1 1953391 D 198215 CDS NP_837516.1 30063345 1078353 1953585..1954088 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 1954088 1078353 S2034 Shigella flexneri 2a str. 2457T IS1 orfB NP_837516.1 1953585 D 198215 CDS NP_837517.1 30063346 1078355 complement(1954526..1955326) 1 NC_004741.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 1955326 otsB 1078355 otsB Shigella flexneri 2a str. 2457T trehalose-6-phosphate phosphatase NP_837517.1 1954526 R 198215 CDS NP_837518.1 30063347 1078356 complement(1955493..1956482) 1 NC_004741.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease 1956482 araH 1078356 araH Shigella flexneri 2a str. 2457T L-arabinose transporter permease NP_837518.1 1955493 R 198215 CDS NP_837519.1 30063348 1078357 complement(1956494..1958008) 1 NC_004741.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 1958008 araG 1078357 araG Shigella flexneri 2a str. 2457T L-arabinose transporter ATP-binding protein NP_837519.1 1956494 R 198215 CDS NP_837520.1 30063349 1078359 1959864..1960367 1 NC_004741.1 residues 1 to 167 of 167 are 100.00 pct identical to residues 1 to 167 of 167 from Escherichia coli K-12 : B1902; ferritin-like protein 1960367 yecI 1078359 yecI Shigella flexneri 2a str. 2457T ferritin-like protein NP_837520.1 1959864 D 198215 CDS NP_837522.1 30063351 1078361 1961162..1961485 1 NC_004741.1 residues 1 to 107 of 107 are 88.78 pct identical to residues 1 to 107 of 107 from Escherichia coli K-12 : B1904; hypothetical protein 1961485 1078361 S2043 Shigella flexneri 2a str. 2457T hypothetical protein NP_837522.1 1961162 D 198215 CDS NP_837523.1 30063352 1078362 1961656..1962153 1 NC_004741.1 cytoplasmic iron storage protein; ferritin 1962153 ftn 1078362 ftn Shigella flexneri 2a str. 2457T ferritin NP_837523.1 1961656 D 198215 CDS NP_837524.1 30063353 1078363 complement(1962190..1962429) 1 NC_004741.1 residues 1 to 79 of 79 are 96.20 pct identical to residues 1 to 79 of 79 from Escherichia coli K-12 : B1906; hypothetical protein 1962429 yecH 1078363 yecH Shigella flexneri 2a str. 2457T hypothetical protein NP_837524.1 1962190 R 198215 CDS NP_837525.1 30063354 1078364 1962619..1963830 1 NC_004741.1 residues 1 to 403 of 403 are 83.62 pct identical to residues 1 to 403 of 403 from Escherichia coli K-12 : B1907; tyrosine-specific transport protein 1963830 tyrP 1078364 tyrP Shigella flexneri 2a str. 2457T tyrosine-specific transport protein NP_837525.1 1962619 D 198215 CDS NP_837526.1 30063355 1078365 complement(1963892..1964557) 1 NC_004741.1 residues 1 to 221 of 221 are 100.00 pct identical to residues 1 to 221 of 221 from Escherichia coli K-12 : B1908; hypothetical protein 1964557 yecA 1078365 yecA Shigella flexneri 2a str. 2457T hypothetical protein NP_837526.1 1963892 R 198215 CDS NP_837527.1 30063356 1078369 complement(1965207..1965755) 1 NC_004741.1 residues 1 to 182 of 182 are 99.45 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 : B1912; phosphatidylglycerophosphate synthetase 1965755 pgsA 1078369 pgsA Shigella flexneri 2a str. 2457T phosphatidylglycerophosphate synthetase NP_837527.1 1965207 R 198215 CDS NP_837528.2 161486474 1078370 complement(1965812..1967644) 1 NC_004741.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1967644 uvrC 1078370 uvrC Shigella flexneri 2a str. 2457T excinuclease ABC subunit C NP_837528.2 1965812 R 198215 CDS NP_837529.1 30063358 1078371 complement(1967641..1968297) 1 NC_004741.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 1968297 uvrY 1078371 uvrY Shigella flexneri 2a str. 2457T response regulator NP_837529.1 1967641 R 198215 CDS NP_837530.1 30063359 1078372 1968756..1968980 1 NC_004741.1 residues 1 to 74 of 74 are 100.00 pct identical to residues 1 to 74 of 74 from Escherichia coli K-12 : B1915; hypothetical protein 1968980 yecF 1078372 yecF Shigella flexneri 2a str. 2457T hypothetical protein NP_837530.1 1968756 D 198215 CDS NP_837531.1 30063360 1078373 complement(1969007..1969633) 1 NC_004741.1 residues 1 to 207 of 208 are 96.13 pct identical to residues 1 to 207 of 240 from Escherichia coli K-12 : B1916; transcriptional regulator of ftsQAZ gene cluster 1969633 sdiA 1078373 sdiA Shigella flexneri 2a str. 2457T transcriptional regulator of ftsQAZ gene cluster NP_837531.1 1969007 R 198215 CDS NP_837532.1 30063361 1078405 complement(1969863..1970615) 1 NC_004741.1 residues 1 to 250 of 250 are 89.60 pct identical to residues 1 to 250 of 250 from Escherichia coli K-12 : B1917; amino-acid ABC transporter ATP-binding protein YecC 1970615 yecC 1078405 yecC Shigella flexneri 2a str. 2457T amino-acid ABC transporter ATP-binding protein YecC NP_837532.1 1969863 R 198215 CDS NP_837533.1 30063362 1078374 complement(1970612..1971280) 1 NC_004741.1 residues 1 to 222 of 222 are 85.58 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 : B1918; transport system permease (former yecC) 1971280 yecS 1078374 yecS Shigella flexneri 2a str. 2457T transport system permease (former yecC) NP_837533.1 1970612 R 198215 CDS NP_837534.2 161486473 1078375 complement(1971295..1972281) 1 NC_004741.1 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 1972281 yedO 1078375 yedO Shigella flexneri 2a str. 2457T D-cysteine desulfhydrase NP_837534.2 1971295 R 198215 CDS NP_837535.1 30063364 1078376 complement(1973275..1973862) 1 NC_004741.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ 1973862 fliZ 1078376 fliZ Shigella flexneri 2a str. 2457T flagella biosynthesis protein FliZ NP_837535.1 1973275 R 198215 CDS NP_837536.1 30063365 1078378 complement(1974756..1976408) 1 NC_004741.1 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin 1976408 fliC 1078378 fliC Shigella flexneri 2a str. 2457T flagellin NP_837536.1 1974756 R 198215 CDS NP_837537.1 30063366 1078379 1976674..1978080 1 NC_004741.1 involved in flagellin assembly; flagellar capping protein 1978080 fliD 1078379 fliD Shigella flexneri 2a str. 2457T flagellar capping protein NP_837537.1 1976674 D 198215 CDS NP_837538.1 30063367 1078392 1978105..1978515 1 NC_004741.1 flagellin specific chaperone; flagellar protein FliS 1978515 fliS 1078392 fliS Shigella flexneri 2a str. 2457T flagellar protein FliS NP_837538.1 1978105 D 198215 CDS NP_837539.1 30063368 1078380 1978515..1978880 1 NC_004741.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 1978880 fliT 1078380 fliT Shigella flexneri 2a str. 2457T flagellar biosynthesis protein FliT NP_837539.1 1978515 D 198215 CDS NP_837540.1 30063369 1077340 1978958..1980445 1 NC_004741.1 converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 1980445 amyA 1077340 amyA Shigella flexneri 2a str. 2457T alpha-amylase NP_837540.1 1978958 D 198215 CDS NP_837541.1 30063370 1078381 complement(1980479..1980892) 1 NC_004741.1 residues 16 to 137 of 137 are 99.18 pct identical to residues 16 to 137 of 137 from Escherichia coli K-12 : B1928; hypothetical protein 1980892 yedD 1078381 yedD Shigella flexneri 2a str. 2457T hypothetical protein NP_837541.1 1980479 R 198215 CDS NP_837542.1 30063371 1076455 1981079..1982284 1 NC_004741.1 residues 1 to 401 of 401 are 86.78 pct identical to residues 1 to 401 of 401 from Escherichia coli K-12 : B1929; inner membrane protein 1982284 yedE 1076455 yedE Shigella flexneri 2a str. 2457T inner membrane protein NP_837542.1 1981079 D 198215 CDS NP_837543.1 30063372 1078382 1982281..1982514 1 NC_004741.1 residues 1 to 77 of 77 are 100.00 pct identical to residues 1 to 77 of 77 from Escherichia coli K-12 : B1930; hypothetical protein 1982514 yedF 1078382 yedF Shigella flexneri 2a str. 2457T hypothetical protein NP_837543.1 1982281 D 198215 CDS NP_837544.1 30063373 1078383 complement(1983331..1984137) 1 NC_004741.1 residues 1 to 268 of 268 are 97.76 pct identical to residues 135 to 402 of 402 from GenPept : >gb|AAG57523.1|AE005470_10 (AE005470) virulence protein [Escherichia coli O157:H7 EDL933]; virulence protein 1984137 1078383 S2072 Shigella flexneri 2a str. 2457T virulence protein NP_837544.1 1983331 R 198215 CDS NP_837545.1 30063374 1078384 1985546..1986628 1 NC_004741.1 residues 1 to 360 of 360 are 84.65 pct identical to residues 1 to 365 of 365 from GenPept : >gb|AAA32301.1| (J02580) outer membrane porin protein [Bacteriophage PA-2]; outer membrane porin protein C precurser 1986628 nmpC 1078384 nmpC Shigella flexneri 2a str. 2457T outer membrane porin protein C precurser NP_837545.1 1985546 D 198215 CDS NP_837546.1 30063375 1076461 complement(1987178..1987915) 1 NC_004741.1 residues 1 to 245 of 245 are 100.00 pct identical to residues 1 to 245 of 245 from NRprotein_Feb03 : >ref|NP_707820.1| ARAC-type regulatory protein [Shigella flexneri 2a str. 301] gb|AAN43527.1|AE015216_2 ARAC-type regulatory protein [Shigella flexneri 2a str. 301]; regulator 1987915 1076461 S4819 Shigella flexneri 2a str. 2457T regulator NP_837546.1 1987178 R 198215 CDS NP_837547.1 30063376 1078386 complement(1987925..1988476) 1 NC_004741.1 DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown; kinase inhibitor 1988476 ybcL 1078386 ybcL Shigella flexneri 2a str. 2457T kinase inhibitor NP_837547.1 1987925 R 198215 CDS NP_837548.1 30063377 1078419 complement(1988645..1988977) 1 NC_004741.1 member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein 1988977 emrE 1078419 emrE Shigella flexneri 2a str. 2457T multidrug efflux protein NP_837548.1 1988645 R 198215 CDS NP_837549.1 30063378 1078390 complement(1989322..1989636) 1 NC_004741.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 1989636 fliE 1078390 fliE Shigella flexneri 2a str. 2457T flagellar hook-basal body protein FliE NP_837549.1 1989322 R 198215 CDS NP_837550.1 30063379 1078393 1991502..1992497 1 NC_004741.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 1992497 fliG 1078393 fliG Shigella flexneri 2a str. 2457T flagellar motor switch protein G NP_837550.1 1991502 D 198215 CDS NP_837551.1 30063380 1079810 1992490..1993176 1 NC_004741.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 1993176 fliH 1079810 fliH Shigella flexneri 2a str. 2457T flagellar assembly protein H NP_837551.1 1992490 D 198215 CDS NP_837552.1 30063381 1078394 1993176..1994549 1 NC_004741.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 1994549 fliI 1078394 fliI Shigella flexneri 2a str. 2457T flagellum-specific ATP synthase NP_837552.1 1993176 D 198215 CDS NP_837553.1 30063382 1079013 1994909..1996036 1 NC_004741.1 residues 1 to 375 of 375 are 93.86 pct identical to residues 1 to 375 of 375 from Escherichia coli K-12 : B1943; flagellar hook-length control protein 1996036 fliK 1079013 fliK Shigella flexneri 2a str. 2457T flagellar hook-length control protein NP_837553.1 1994909 D 198215 CDS NP_837554.1 30063383 1078398 1996141..1996605 1 NC_004741.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 1996605 fliL 1078398 fliL Shigella flexneri 2a str. 2457T flagellar basal body-associated protein FliL NP_837554.1 1996141 D 198215 CDS NP_837555.1 30063384 1076460 1996610..1997614 1 NC_004741.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 1997614 fliM 1076460 fliM Shigella flexneri 2a str. 2457T flagellar motor switch protein FliM NP_837555.1 1996610 D 198215 CDS NP_837556.1 30063385 1078399 1997611..1998024 1 NC_004741.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 1998024 fliN 1078399 fliN Shigella flexneri 2a str. 2457T flagellar motor switch protein FliN NP_837556.1 1997611 D 198215 CDS NP_837557.2 161486472 1078400 1998027..1998392 1 NC_004741.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 1998392 fliO 1078400 fliO Shigella flexneri 2a str. 2457T flagellar biosynthesis protein FliO NP_837557.2 1998027 D 198215 CDS NP_837558.1 30063387 1078402 1999167..1999436 1 NC_004741.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 1999436 fliQ 1078402 fliQ Shigella flexneri 2a str. 2457T flagellar biosynthesis protein FliQ NP_837558.1 1999167 D 198215 CDS NP_837559.1 30063388 1078403 1999445..2000230 1 NC_004741.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2000230 fliR 1078403 fliR Shigella flexneri 2a str. 2457T flagellar biosynthesis protein FliR NP_837559.1 1999445 D 198215 CDS NP_837560.1 30063389 1076708 2000515..2001138 1 NC_004741.1 residues 1 to 207 of 207 are 99.51 pct identical to residues 1 to 207 of 207 from Escherichia coli K-12 : B1951; positive regulator for ctr capsule biosynthesis, positive transcription factor 2001138 rcsA 1076708 rcsA Shigella flexneri 2a str. 2457T positive regulator for ctr capsule biosynthesis, positive transcription factor NP_837560.1 2000515 D 198215 CDS NP_837561.1 30063390 1078404 complement(2001182..2001370) 1 NC_004741.1 residues 1 to 62 of 62 are 98.38 pct identical to residues 1 to 62 of 62 from Escherichia coli K-12 : B1952; hypothetical protein 2001370 dsrB 1078404 dsrB Shigella flexneri 2a str. 2457T hypothetical protein NP_837561.1 2001182 R 198215 CDS NP_837562.1 30063391 1078406 2001533..2001760 1 NC_004741.1 residues 1 to 75 of 75 are 98.66 pct identical to residues 6 to 80 of 80 from Escherichia coli K-12 : B1953; hypothetical protein 2001760 1078406 S2092 Shigella flexneri 2a str. 2457T hypothetical protein NP_837562.1 2001533 D 198215 CDS NP_837563.1 30063392 1078413 complement(2004735..2004917) 1 NC_004741.1 residues 1 to 60 of 60 are 98.33 pct identical to residues 1 to 60 of 60 from Escherichia coli K-12 : B1957; hypothetical protein 2004917 1078413 S2096 Shigella flexneri 2a str. 2457T hypothetical protein NP_837563.1 2004735 R 198215 CDS NP_837564.1 30063393 1079036 complement(2004996..2005913) 1 NC_004741.1 residues 23 to 305 of 305 are 87.98 pct identical to residues 23 to 305 of 305 from Escherichia coli K-12 : B1958; hypothetical protein 2005913 yedI 1079036 yedI Shigella flexneri 2a str. 2457T hypothetical protein NP_837564.1 2004996 R 198215 CDS NP_837565.1 30063394 1078414 2006086..2007006 1 NC_004741.1 residues 1 to 306 of 306 are 83.33 pct identical to residues 1 to 306 of 306 from Escherichia coli K-12 : B1959; hypothetical protein 2007006 yedA 1078414 yedA Shigella flexneri 2a str. 2457T hypothetical protein NP_837565.1 2006086 D 198215 CDS NP_837566.1 30063395 1078415 complement(2006995..2007465) 1 NC_004741.1 residues 1 to 156 of 156 are 98.07 pct identical to residues 1 to 156 of 156 from Escherichia coli K-12 : B1960; DNA mismatch endonuclease, patch repair protein 2007465 vsr 1078415 vsr Shigella flexneri 2a str. 2457T DNA mismatch endonuclease, patch repair protein NP_837566.1 2006995 R 198215 CDS NP_837567.1 30063396 1080935 complement(2007446..2008864) 1 NC_004741.1 residues 1 to 472 of 472 are 99.15 pct identical to residues 1 to 472 of 472 from Escherichia coli K-12 : B1961; DNA cytosine methylase 2008864 dcm 1080935 dcm Shigella flexneri 2a str. 2457T DNA cytosine methylase NP_837567.1 2007446 R 198215 CDS NP_837568.1 30063397 1078418 complement(2009769..2010581) 1 NC_004741.1 residues 1 to 270 of 270 are 95.55 pct identical to residues 10 to 279 of 279 from GenPept : >gb|AAG53988.1|AF327445_2 (AF327445) transposase B [Pantoea agglomerans]; ISEhe3 orfB 2010581 1078418 S2103 Shigella flexneri 2a str. 2457T ISEhe3 orfB NP_837568.1 2009769 R 198215 CDS NP_837569.1 30063398 1078417 complement(2010638..2010916) 1 NC_004741.1 residues 1 to 92 of 92 are 92.39 pct identical to residues 3 to 94 of 94 from GenPept : >gb|AAG53987.1|AF327445_1 (AF327445) transposase A [Pantoea agglomerans]; ISEhe3 orfA 2010916 1078417 S2104 Shigella flexneri 2a str. 2457T ISEhe3 orfA NP_837569.1 2010638 R 198215 CDS NP_837570.1 30063399 1078420 2010943..2011830 1 NC_004741.1 residues 31 to 267 of 295 are 59.18 pct identical to residues 53 to 296 of 351 from GenPept : >emb|CAA23605.1| (V00316) phoE protein [Escherichia coli]; outer membrane pore protein 2011830 1078420 S2105 Shigella flexneri 2a str. 2457T outer membrane pore protein NP_837570.1 2010943 D 198215 CDS NP_837571.2 161486471 1078421 complement(2011755..2012660) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2012660 1078421 S2106 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_837571.2 2011755 R 198215 CDS NP_837572.2 161486470 1078422 complement(2012618..2012983) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2012983 1078422 S2107 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_837572.2 2012618 R 198215 CDS NP_837573.1 30063402 1078423 2013047..2013256 1 NC_004741.1 residues 2 to 69 of 69 are 61.76 pct identical to residues 298 to 359 of 359 from GenPept : >emb|CAA09665.1| (AJ011501) OmpK35 porin [Klebsiella pneumoniae]; outer membrane protein 2013256 1078423 S2108 Shigella flexneri 2a str. 2457T outer membrane protein NP_837573.1 2013047 D 198215 CDS NP_837574.1 30063403 1078424 2013884..2014159 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2014159 1078424 S2109 Shigella flexneri 2a str. 2457T IS1 orfA NP_837574.1 2013884 D 198215 CDS NP_837575.1 30063404 1078433 2014078..2014581 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2014581 1078433 S2110 Shigella flexneri 2a str. 2457T IS1 orfB NP_837575.1 2014078 D 198215 CDS NP_837576.1 30063405 1078425 2014627..2015499 1 NC_004741.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2015499 yedU 1078425 yedU Shigella flexneri 2a str. 2457T chaperone protein HchA NP_837576.1 2014627 D 198215 CDS NP_837577.1 30063406 1078407 complement(2015585..2016943) 1 NC_004741.1 residues 1 to 452 of 452 are 93.14 pct identical to residues 1 to 452 of 452 from Escherichia coli K-12 : B1968; 2-component sensor protein 2016943 yedV 1078407 yedV Shigella flexneri 2a str. 2457T 2-component sensor protein NP_837577.1 2015585 R 198215 CDS NP_837578.1 30063407 1078427 complement(2016943..2017614) 1 NC_004741.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 2017614 yedW 1078427 yedW Shigella flexneri 2a str. 2457T transcriptional regulatory protein YedW NP_837578.1 2016943 R 198215 CDS NP_837579.1 30063408 1076469 2017747..2018160 1 NC_004741.1 residues 1 to 137 of 137 are 99.27 pct identical to residues 1 to 137 of 137 from Escherichia coli K-12 : B1970; hypothetical protein 2018160 1076469 S2114 Shigella flexneri 2a str. 2457T hypothetical protein NP_837579.1 2017747 D 198215 CDS NP_837580.1 30063409 1078429 2019274..2019909 1 NC_004741.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2019909 1078429 S2116 Shigella flexneri 2a str. 2457T sulfite oxidase subunit YedZ NP_837580.1 2019274 D 198215 CDS NP_837581.1 30063410 1078431 2020167..2020817 1 NC_004741.1 residues 2 to 205 of 217 are 92.64 pct identical to residues 1 to 204 of 216 from Escherichia coli K-12 : B1973; hypothetical protein 2020817 1078431 S2117 Shigella flexneri 2a str. 2457T hypothetical protein NP_837581.1 2020167 D 198215 CDS NP_837582.1 30063411 1078432 complement(2021895..2022164) 1 NC_004741.1 residues 1 to 77 of 89 are 92.20 pct identical to residues 1 to 77 of 82 from GenPept : >gb|AAG56015.1|AE005334_2 (AE005334) unknown protein encoded by prophage CP-933X [Escherichia coli O157:H7 EDL933]; bacteriophage protein 2022164 1078432 S2118 Shigella flexneri 2a str. 2457T bacteriophage protein NP_837582.1 2021895 R 198215 CDS NP_837583.1 30063412 1078434 2023205..2024848 1 NC_004741.1 residues 1 to 547 of 547 are 72.48 pct identical to residues 1 to 565 of 565 from NRprotein_Feb03 : >ref|NP_085238.1| invasion plasmid antigen [Shigella flexneri] emb|CAC05787.1| IpaH7.8, member of the IpaH family, secreted by the Mxi-Spa secretion machinery, function unknown [Shigella flexneri]; invasion plasmid antigen 2024848 ipaH_5 1078434 ipaH_5 Shigella flexneri 2a str. 2457T invasion plasmid antigen NP_837583.1 2023205 D 198215 CDS NP_837584.1 30063413 1078435 complement(2025028..2025405) 1 NC_004741.1 residues 1 to 125 of 125 are 68.80 pct identical to residues 64 to 188 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein 2025405 1078435 S2121 Shigella flexneri 2a str. 2457T hypothetical protein NP_837584.1 2025028 R 198215 CDS NP_837585.1 30063414 1078437 2026462..2026737 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2026737 1078437 S2122 Shigella flexneri 2a str. 2457T IS1 orfA NP_837585.1 2026462 D 198215 CDS NP_837586.1 30063415 1078438 2026656..2027159 1 NC_004741.1 residues 1 to 97 of 97 are 82.47 pct identical to residues 71 to 167 of 167 from GenPept : >gb|AAK18549.1|AF348706_238 (AF348706) iso-IS1 orfB [Shigella flexneri]; IS1 orfB 2027159 1078438 S2123 Shigella flexneri 2a str. 2457T IS1 orfB NP_837586.1 2026656 D 198215 CDS NP_837587.1 30063416 1078439 complement(2027802..2029751) 1 NC_004741.1 residues 1 to 649 of 649 are 85.20 pct identical to residues 1 to 649 of 649 from GenPept : >emb|CAC83565.1| (AJ298298) tail protein [Bacteriophage P27]; tail protein 2029751 1078439 S2124 Shigella flexneri 2a str. 2457T tail protein NP_837587.1 2027802 R 198215 CDS NP_837588.1 30063417 1078440 complement(2029836..2030171) 1 NC_004741.1 residues 3 to 111 of 111 are 97.24 pct identical to residues 1 to 109 of 109 from GenPept : >emb|CAC83564.1| (AJ298298) hypothetical protein [Bacteriophage P27]; bacteriophage protein 2030171 1078440 S2126 Shigella flexneri 2a str. 2457T bacteriophage protein NP_837588.1 2029836 R 198215 CDS NP_837589.1 30063418 1078441 complement(2030171..2030527) 1 NC_004741.1 residues 1 to 118 of 118 are 98.30 pct identical to residues 1 to 118 of 118 from GenPept : >emb|CAC83563.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein 2030527 1078441 S2127 Shigella flexneri 2a str. 2457T hypothetical protein NP_837589.1 2030171 R 198215 CDS NP_837590.1 30063419 1078442 complement(2030527..2032023) 1 NC_004741.1 residues 1 to 498 of 498 are 91.16 pct identical to residues 1 to 498 of 498 from GenPept : >emb|CAC83562.1| (AJ298298) sheath protein [Bacteriophage P27]; sheath protein 2032023 1078442 S2128 Shigella flexneri 2a str. 2457T sheath protein NP_837590.1 2030527 R 198215 CDS NP_837591.1 30063420 1078443 complement(2032191..2032445) 1 NC_004741.1 residues 1 to 83 of 84 are 98.79 pct identical to residues 104 to 186 of 187 from GenPept : >emb|CAC83561.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein 2032445 1078443 S2129 Shigella flexneri 2a str. 2457T hypothetical protein NP_837591.1 2032191 R 198215 CDS NP_837592.1 30063421 1078445 complement(2032575..2033288) 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 2033288 1078445 S2130 Shigella flexneri 2a str. 2457T IS600 orfB NP_837592.1 2032575 R 198215 CDS NP_837593.1 30063422 1078446 complement(2033429..2033731) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 2033731 1078446 S2131 Shigella flexneri 2a str. 2457T IS600 orfA NP_837593.1 2033429 R 198215 CDS NP_837594.1 30063423 1078447 complement(2034606..2034956) 1 NC_004741.1 residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAK18528.1|AF348706_217 (AF348706) IS orf [Shigella flexneri]; partial; ISSfl3 orfB 2034956 1078447 S2133 Shigella flexneri 2a str. 2457T ISSfl3 orfB NP_837594.1 2034606 R 198215 CDS NP_837595.1 30063424 1078449 complement(2034953..2035450) 1 NC_004741.1 residues 1 to 165 of 165 are 99.39 pct identical to residues 60 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 2035450 1078449 S2134 Shigella flexneri 2a str. 2457T ISSfl3 orfA NP_837595.1 2034953 R 198215 CDS NP_837596.1 30063425 1076436 complement(2036742..2037425) 1 NC_004741.1 residues 1 to 227 of 227 are 92.95 pct identical to residues 1 to 227 of 229 from GenPept : >gb|AAK16973.1|AE006460_11 (AE006460) Q antiterminator encoded by prophage CP-933P [Escherichia coli O157:H7 EDL933]; Q antiterminator of prophage 2037425 1076436 S2139 Shigella flexneri 2a str. 2457T Q antiterminator of prophage NP_837596.1 2036742 R 198215 CDS NP_837597.1 30063426 1078451 complement(2037422..2037787) 1 NC_004741.1 residues 4 to 121 of 121 are 96.61 pct identical to residues 2 to 119 of 119 from GenPept : >gb|AAK16974.1|AE006460_12 (AE006460) endonuclease encoded by cryptic prophage CP-933P [Escherichia coli O157:H7 EDL933]; crossover junction endodeoxyribonuclease 2037787 1078451 S2140 Shigella flexneri 2a str. 2457T crossover junction endodeoxyribonuclease NP_837597.1 2037422 R 198215 CDS NP_837598.1 30063427 1078452 complement(2037788..2038774) 1 NC_004741.1 residues 1 to 324 of 328 are 79.32 pct identical to residues 25 to 347 of 348 from GenPept : >dbj|BAB35199.1| (AP002556) hypothetical protein [Escherichia coli O157:H7]; hypothetical protein 2038774 1078452 S2142 Shigella flexneri 2a str. 2457T hypothetical protein NP_837598.1 2037788 R 198215 CDS NP_837599.1 30063428 1079750 2038773..2039252 1 NC_004741.1 residues 53 to 159 of 159 are 96.26 pct identical to residues 1 to 107 of 107 from GenPept : >gb|AAG57026.1|AE005422_1 (AE005422) unknown protein encoded within prophage CP-933U [Escherichia coli O157:H7 EDL933]; hypothetical protein 2039252 1079750 S2141 Shigella flexneri 2a str. 2457T hypothetical protein NP_837599.1 2038773 D 198215 CDS NP_837600.1 30063429 1078453 complement(2039294..2039506) 1 NC_004741.1 residues 1 to 70 of 70 are 81.42 pct identical to residues 1 to 70 of 70 from GenPept : >gb|AAK16976.1|AE006461_1 (AE006461) cell killing protein encoded within cryptic prophage CP-933P [Escherichia coli O157:H7 EDL933]; cell killing protein of prophage 2039506 1078453 S2143 Shigella flexneri 2a str. 2457T cell killing protein of prophage NP_837600.1 2039294 R 198215 CDS NP_837601.1 30063430 1078454 complement(2040101..2040436) 1 NC_004741.1 residues 4 to 93 of 111 are 37.25 pct identical to residues 28 to 122 of 151 from GenPept : >dbj|BAB12619.1| (AP002527) ycgB [Escherichia coli]; hypothetical protein 2040436 1078454 S2144 Shigella flexneri 2a str. 2457T hypothetical protein NP_837601.1 2040101 R 198215 CDS NP_837602.1 30063431 1080982 2040562..2040684 1 NC_004741.1 residues 1 to 40 of 40 are 85.00 pct identical to residues 28 to 67 of 67 from GenPept : >dbj|BAB36195.1| (AP002559) hypothetical protein [Escherichia coli O157:H7]; hypothetical protein 2040684 1080982 S2145 Shigella flexneri 2a str. 2457T hypothetical protein NP_837602.1 2040562 D 198215 CDS NP_837603.1 30063432 1078455 2040864..2041709 1 NC_004741.1 residues 1 to 281 of 281 are 93.23 pct identical to residues 60 to 340 of 340 from GenPept : >gb|AAG57039.1|AE005423_1 (AE005423) integrase for prophage CP-933U [Escherichia coli O157:H7 EDL933]; integrase for prophage CP-933U 2041709 1078455 S2146 Shigella flexneri 2a str. 2457T integrase for prophage CP-933U NP_837603.1 2040864 D 198215 CDS NP_837604.1 30063433 1078468 2041906..2042742 1 NC_004741.1 residues 1 to 278 of 278 are 98.92 pct identical to residues 1 to 278 of 278 from Escherichia coli K-12 : B1976; hypothetical protein 2042742 1078468 S2148 Shigella flexneri 2a str. 2457T hypothetical protein NP_837604.1 2041906 D 198215 CDS NP_837605.1 30063434 1079040 2043593..2044342 1 NC_004741.1 residues 1 to 249 of 249 are 95.18 pct identical to residues 56 to 304 of 304 from GenPept : >emb|CAB59975.1| (AJ245585) integrase [Escherichia coli]; integrase 2044342 1079040 S2152 Shigella flexneri 2a str. 2457T integrase NP_837605.1 2043593 D 198215 CDS NP_837606.1 30063435 1078240 complement(2045315..2045545) 1 NC_004741.1 residues 1 to 76 of 76 are 98.68 pct identical to residues 37 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS911 orfA 2045545 1078240 S2155 Shigella flexneri 2a str. 2457T IS911 orfA NP_837606.1 2045315 R 198215 CDS NP_837607.1 30063436 1078462 2046243..2046545 1 NC_004741.1 residues 1 to 100 of 100 are 99.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAK18566.1|AF348706_255 (AF348706) IS600 orfA [Shigella flexneri]; IS600 orfA 2046545 1078462 S2157 Shigella flexneri 2a str. 2457T IS600 orfA NP_837607.1 2046243 D 198215 CDS NP_837608.1 30063437 1078463 2046686..2047399 1 NC_004741.1 residues 1 to 237 of 237 are 99.57 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72454.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 2047399 1078463 S2158 Shigella flexneri 2a str. 2457T IS600 orfB NP_837608.1 2046686 D 198215 CDS NP_837609.1 30063438 1078465 2047751..2049205 1 NC_004741.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2049205 amn 1078465 amn Shigella flexneri 2a str. 2457T AMP nucleosidase NP_837609.1 2047751 D 198215 CDS NP_837610.1 30063439 1078466 2049548..2050264 1 NC_004741.1 residues 1 to 238 of 238 are 99.57 pct identical to residues 1 to 238 of 238 from Escherichia coli K-12 : B1983; hypothetical protein 2050264 1078466 S2161 Shigella flexneri 2a str. 2457T hypothetical protein NP_837610.1 2049548 D 198215 CDS NP_837611.1 30063440 1078471 complement(2052641..2053591) 1 NC_004741.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 2053591 cbl 1078471 cbl Shigella flexneri 2a str. 2457T transcriptional regulator Cbl NP_837611.1 2052641 R 198215 CDS NP_837612.1 30063441 1078472 complement(2053693..2054610) 1 NC_004741.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 2054610 nac 1078472 nac Shigella flexneri 2a str. 2457T nitrogen assimilation transcriptional regulator NP_837612.1 2053693 R 198215 CDS NP_837613.1 30063442 1078474 complement(2055069..2056004) 1 NC_004741.1 residues 2 to 311 of 311 are 97.41 pct identical to residues 1 to 310 of 310 from Escherichia coli K-12 : B1990; hypothetical protein 2056004 erfK 1078474 erfK Shigella flexneri 2a str. 2457T hypothetical protein NP_837613.1 2055069 R 198215 CDS NP_837614.1 30063443 1078475 complement(2056066..2057145) 1 NC_004741.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2057145 cobT 1078475 cobT Shigella flexneri 2a str. 2457T nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase NP_837614.1 2056066 R 198215 CDS NP_837615.1 30063444 1078504 complement(2057157..2057900) 1 NC_004741.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2057900 cobS 1078504 cobS Shigella flexneri 2a str. 2457T cobalamin synthase NP_837615.1 2057157 R 198215 CDS NP_837616.1 30063445 1078502 complement(2058418..2059131) 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 2059131 1078502 S2172 Shigella flexneri 2a str. 2457T IS600 orfB NP_837616.1 2058418 R 198215 CDS NP_837617.1 30063446 1078478 complement(2059272..2059574) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 2059574 1078478 S2173 Shigella flexneri 2a str. 2457T IS600 orfA NP_837617.1 2059272 R 198215 CDS NP_837618.1 30063447 1078483 2059817..2060143 1 NC_004741.1 residues 1 to 108 of 108 are 89.81 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72412.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA 2060143 is629a 1078483 is629a Shigella flexneri 2a str. 2457T IS629 orfA NP_837618.1 2059817 D 198215 CDS NP_837619.1 30063448 1078484 2060379..2061026 1 NC_004741.1 residues 1 to 215 of 215 are 99.06 pct identical to residues 8 to 222 of 222 from GenPept : >gb|AAL72361.1| (AF386526) transposase [Shigella flexneri 2a]; IS629 orfB 2061026 is629b 1078484 is629b Shigella flexneri 2a str. 2457T IS629 orfB NP_837619.1 2060379 D 198215 CDS NP_837620.1 30063449 1078480 complement(2061887..2062282) 1 NC_004741.1 residues 1 to 131 of 131 are 100.00 pct identical to residues 1 to 131 of 131 from Escherichia coli K-12 : B2007; hypothetical protein 2062282 yeeX 1078480 yeeX Shigella flexneri 2a str. 2457T hypothetical protein NP_837620.1 2061887 R 198215 CDS NP_837621.1 30063450 1078486 2062757..2063431 1 NC_004741.1 residues 1 to 224 of 224 are 100.00 pct identical to residues 1 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 2063431 1078486 S2179 Shigella flexneri 2a str. 2457T ISSfl3 orfA NP_837621.1 2062757 D 198215 CDS NP_837622.1 30063451 1076977 2063428..2063640 1 NC_004741.1 residues 1 to 57 of 70 are 100.00 pct identical to residues 1 to 57 of 115 from GenPept : >gb|AAL72465.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfB 2063640 1076977 S2180 Shigella flexneri 2a str. 2457T ISSfl3 orfB NP_837622.1 2063428 D 198215 CDS NP_837623.1 30063452 1078487 complement(2063643..2064161) 1 NC_004741.1 residues 1 to 172 of 172 are 98.83 pct identical to residues 35 to 206 of 206 from GenPept : >gb|AAD44736.1|AF141323_7 (AF141323) TnpC [Shigella flexneri]; IS629 orfA 2064161 1078487 S2181 Shigella flexneri 2a str. 2457T IS629 orfA NP_837623.1 2063643 R 198215 CDS NP_837624.1 30063453 1078507 complement(2064173..2064526) 1 NC_004741.1 residues 1 to 117 of 117 are 100.00 pct identical to residues 1 to 117 of 117 from GenPept : >gb|AAK18555.1|AF348706_244 (AF348706) IS629 orf [Shigella flexneri]; IS629 orfB 2064526 1078507 S2182 Shigella flexneri 2a str. 2457T IS629 orfB NP_837624.1 2064173 R 198215 CDS NP_837625.1 30063454 1079406 2065084..2066685 1 NC_004741.1 residues 1 to 533 of 533 are 97.37 pct identical to residues 1 to 533 of 533 from GenPept : >gb|AAL72472.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfC 2066685 1079406 S2184 Shigella flexneri 2a str. 2457T ISSfl3 orfC NP_837625.1 2065084 D 198215 CDS NP_837626.1 30063455 1078488 2066754..2067068 1 NC_004741.1 residues 13 to 95 of 104 are 34.88 pct identical to residues 325 to 410 of 416 from GenPept : >gb|AAL09885.1| (AY048727) integrase [CRIM helper plasmid pAH129]; hypothetical protein 2067068 1078488 S2185 Shigella flexneri 2a str. 2457T hypothetical protein NP_837626.1 2066754 D 198215 CDS NP_837627.1 30063456 1078490 complement(2067528..2067776) 1 NC_004741.1 residues 1 to 82 of 82 are 97.56 pct identical to residues 452 to 533 of 533 from GenPept : >gb|AAL72472.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; ISSfl3 orfD 2067776 1078490 S2187 Shigella flexneri 2a str. 2457T ISSfl3 orfD NP_837627.1 2067528 R 198215 CDS NP_837628.1 30063457 1078811 complement(2068553..2069125) 1 NC_004741.1 residues 1 to 190 of 190 are 93.15 pct identical to residues 1 to 190 of 190 from GenPept : >gb|AAK18527.1|AF348706_216 (AF348706) IS orf [Shigella flexneri]; ISSfl3 orfC 2069125 1078811 S2189 Shigella flexneri 2a str. 2457T ISSfl3 orfC NP_837628.1 2068553 R 198215 CDS NP_837629.1 30063458 1078491 complement(2069122..2069472) 1 NC_004741.1 residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAL72462.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfB 2069472 1078491 S2190 Shigella flexneri 2a str. 2457T ISSfl3 orfB NP_837629.1 2069122 R 198215 CDS NP_837630.1 30063459 1079728 complement(2069469..2069966) 1 NC_004741.1 residues 1 to 165 of 165 are 99.39 pct identical to residues 60 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 2069966 1079728 S2191 Shigella flexneri 2a str. 2457T ISSfl3 orfA NP_837630.1 2069469 R 198215 CDS NP_837631.1 30063460 1078492 2071243..2072667 1 NC_004741.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2072667 sbcB 1078492 sbcB Shigella flexneri 2a str. 2457T exonuclease I NP_837631.1 2071243 D 198215 CDS NP_837632.1 30063461 1078408 complement(2072710..2072937) 1 NC_004741.1 residues 1 to 75 of 75 are 97.33 pct identical to residues 1 to 75 of 75 from Escherichia coli K-12 : B2012; hypothetical protein 2072937 yeeD 1078408 yeeD Shigella flexneri 2a str. 2457T hypothetical protein NP_837632.1 2072710 R 198215 CDS NP_837633.1 30063462 1078493 complement(2072951..2074009) 1 NC_004741.1 residues 1 to 352 of 352 are 93.18 pct identical to residues 1 to 352 of 352 from Escherichia coli K-12 : B2013; transport system permease 2074009 yeeE 1078493 yeeE Shigella flexneri 2a str. 2457T transport system permease NP_837633.1 2072951 R 198215 CDS NP_837634.1 30063463 1077380 complement(2074188..2075546) 1 NC_004741.1 residues 1 to 452 of 452 are 89.82 pct identical to residues 3 to 454 of 454 from Escherichia coli K-12 : B2014; amino acid/amine transport protein 2075546 yeeF 1077380 yeeF Shigella flexneri 2a str. 2457T amino acid/amine transport protein NP_837634.1 2074188 R 198215 CDS NP_837635.1 30063464 1078495 complement(2075759..2076742) 1 NC_004741.1 residues 1 to 309 of 327 are 99.35 pct identical to residues 8 to 316 of 316 from Escherichia coli K-12 : B2015; LYSR-type transcriptional regulator 2076742 yeeY 1078495 yeeY Shigella flexneri 2a str. 2457T LYSR-type transcriptional regulator NP_837635.1 2075759 R 198215 CDS NP_837636.1 30063465 1078496 complement(2076788..2077612) 1 NC_004741.1 residues 1 to 274 of 274 are 94.52 pct identical to residues 1 to 274 of 274 from Escherichia coli K-12 : B2016; enzyme of sugar metabolism 2077612 1078496 S2198 Shigella flexneri 2a str. 2457T enzyme of sugar metabolism NP_837636.1 2076788 R 198215 CDS NP_837637.1 30063466 1078497 complement(2077971..2078264) 1 NC_004741.1 residues 1 to 97 of 97 are 82.47 pct identical to residues 71 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS1 orfB 2078264 1078497 S2199 Shigella flexneri 2a str. 2457T IS1 orfB NP_837637.1 2077971 R 198215 CDS NP_837638.1 30063467 1078498 complement(2078392..2078667) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2078667 1078498 S2200 Shigella flexneri 2a str. 2457T IS1 orfA NP_837638.1 2078392 R 198215 CDS NP_837639.1 30063468 1078481 complement(2078701..2078973) 1 NC_004741.1 Antitoxin that counteracts the effect of the YoeB toxin; antitoxin YefM 2078973 yefM 1078481 yefM Shigella flexneri 2a str. 2457T antitoxin YefM NP_837639.1 2078701 R 198215 CDS NP_837640.1 30063469 1078501 2079443..2080342 1 NC_004741.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2080342 hisG 1078501 hisG Shigella flexneri 2a str. 2457T ATP phosphoribosyltransferase NP_837640.1 2079443 D 198215 CDS NP_837641.1 30063470 1078511 2080348..2081652 1 NC_004741.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2081652 hisD 1078511 hisD Shigella flexneri 2a str. 2457T histidinol dehydrogenase NP_837641.1 2080348 D 198215 CDS NP_837642.1 30063471 1078503 2081649..2082719 1 NC_004741.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2082719 hisC 1078503 hisC Shigella flexneri 2a str. 2457T histidinol-phosphate aminotransferase NP_837642.1 2081649 D 198215 CDS NP_837643.1 30063472 1078505 2082719..2083786 1 NC_004741.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2083786 hisB 1078505 hisB Shigella flexneri 2a str. 2457T imidazole glycerol-phosphate dehydratase/histidinol phosphatase NP_837643.1 2082719 D 198215 CDS NP_837644.1 30063473 1078489 2083786..2084376 1 NC_004741.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2084376 hisH 1078489 hisH Shigella flexneri 2a str. 2457T imidazole glycerol phosphate synthase subunit HisH NP_837644.1 2083786 D 198215 CDS NP_837645.1 30063474 1078508 2084376..2085113 1 NC_004741.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2085113 hisA 1078508 hisA Shigella flexneri 2a str. 2457T 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase NP_837645.1 2084376 D 198215 CDS NP_837646.1 30063475 1076502 2085095..2085871 1 NC_004741.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2085871 hisF 1076502 hisF Shigella flexneri 2a str. 2457T imidazole glycerol phosphate synthase subunit HisF NP_837646.1 2085095 D 198215 CDS NP_837647.1 30063476 1078510 2085865..2086476 1 NC_004741.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP 2086476 hisI 1078510 hisI Shigella flexneri 2a str. 2457T bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP NP_837647.1 2085865 D 198215 CDS NP_837648.1 30063477 1077593 complement(2086662..2087675) 1 NC_004741.1 residues 1 to 337 of 337 are 82.24 pct identical to residues 1 to 338 of 338 from Escherichia coli K-12 : B2027; regulator of length of O-antigen component of lipopolysaccharide chains 2087675 wzzB 1077593 wzzB Shigella flexneri 2a str. 2457T regulator of length of O-antigen component of lipopolysaccharide chains NP_837648.1 2086662 R 198215 CDS NP_837649.1 30063478 1078514 complement(2089155..2090561) 1 NC_004741.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2090561 gnd 1078514 gnd Shigella flexneri 2a str. 2457T 6-phosphogluconate dehydrogenase NP_837649.1 2089155 R 198215 CDS NP_837650.1 30063479 1078515 complement(2090670..2091029) 1 NC_004741.1 residues 1 to 119 of 119 are 100.00 pct identical to residues 1 to 119 of 119 from GenPept : >emb|CAA50780.1| (X71970) ORG12x8 [Shigella flexneri]; hypothetical protein 2091029 1078515 S2213 Shigella flexneri 2a str. 2457T hypothetical protein NP_837650.1 2090670 R 198215 CDS NP_837651.1 30063480 1078516 complement(2091026..2091577) 1 NC_004741.1 residues 1 to 183 of 183 are 100.00 pct identical to residues 1 to 183 of 183 from GenPept : >emb|CAA50779.1| (X71970) ORG12x3 [Shigella flexneri]; hypothetical protein 2091577 1078516 S2214 Shigella flexneri 2a str. 2457T hypothetical protein NP_837651.1 2091026 R 198215 CDS NP_837652.1 30063481 1078517 complement(2091678..2092277) 1 NC_004741.1 residues 1 to 199 of 199 are 88.94 pct identical to residues 1 to 199 of 199 from GenPept : >emb|CAA50778.1| (X71970) ORF11x6 [Shigella flexneri]; hypothetical protein 2092277 1078517 S2215 Shigella flexneri 2a str. 2457T hypothetical protein NP_837652.1 2091678 R 198215 CDS NP_837653.1 30063482 1078519 complement(2092448..2092939) 1 NC_004741.1 residues 1 to 163 of 163 are 100.00 pct identical to residues 1 to 163 of 163 from GenPept : >emb|CAA50777.1| (X71970) ORF10x9 [Shigella flexneri]; hypothetical protein 2092939 1078519 S2216 Shigella flexneri 2a str. 2457T hypothetical protein NP_837653.1 2092448 R 198215 CDS NP_837654.1 30063483 1078512 complement(2092997..2093386) 1 NC_004741.1 residues 1 to 70 of 129 are 100.00 pct identical to residues 1 to 70 of 76 from GenPept : >emb|CAA50776.1| (X71970) rfbJ [Shigella flexneri]; glycosyl transferase 2093386 rfbJ 1078512 rfbJ Shigella flexneri 2a str. 2457T glycosyl transferase NP_837654.1 2092997 R 198215 CDS NP_837655.1 30063484 1078520 complement(2093449..2093823) 1 NC_004741.1 residues 1 to 124 of 124 are 89.51 pct identical to residues 1 to 124 of 124 from GenPept : >emb|CAA50775.1| (X71970) rfbI [Shigella flexneri]; glycosyl translocase 2093823 rfbI 1078520 rfbI Shigella flexneri 2a str. 2457T glycosyl translocase NP_837655.1 2093449 R 198215 CDS NP_837656.1 30063485 1078521 complement(2093827..2094975) 1 NC_004741.1 residues 1 to 382 of 382 are 76.43 pct identical to residues 1 to 382 of 382 from GenPept : >emb|CAA50774.1| (X71970) rfc [Shigella flexneri]; O-antigen polymerase 2094975 rfc 1078521 rfc Shigella flexneri 2a str. 2457T O-antigen polymerase NP_837656.1 2093827 R 198215 CDS NP_837657.1 30063486 1078499 complement(2094995..2095864) 1 NC_004741.1 residues 1 to 289 of 289 are 100.00 pct identical to residues 1 to 289 of 289 from GenPept : >emb|CAA50773.1| (X71970) rfbG [Shigella flexneri]; dTDP-rhamnosyl transferase 2095864 rfbG 1078499 rfbG Shigella flexneri 2a str. 2457T dTDP-rhamnosyl transferase NP_837657.1 2094995 R 198215 CDS NP_837658.1 30063487 1078523 complement(2095893..2096783) 1 NC_004741.1 residues 1 to 296 of 296 are 100.00 pct identical to residues 1 to 296 of 296 from GenPept : >emb|CAA50772.1| (X71970) rfbF [Shigella flexneri]; dTDP-rhamnosyl transferase 2096783 rfbF 1078523 rfbF Shigella flexneri 2a str. 2457T dTDP-rhamnosyl transferase NP_837658.1 2095893 R 198215 CDS NP_837659.1 30063488 1078524 complement(2096813..2098069) 1 NC_004741.1 residues 1 to 418 of 418 are 99.52 pct identical to residues 1 to 418 of 418 from GenPept : >emb|CAA50771.1| (X71970) rfbE [Shigella flexneri]; polysaccharide biosynthesis protein 2098069 rfbE 1078524 rfbE Shigella flexneri 2a str. 2457T polysaccharide biosynthesis protein NP_837659.1 2096813 R 198215 CDS NP_837660.1 30063489 1078525 complement(2098085..2098630) 1 NC_004741.1 residues 1 to 181 of 181 are 97.95 pct identical to residues 1 to 181 of 181 from GenPept : >emb|CAA50770.1| (X71970) rfbD [Shigella flexneri]; This protein is named RfbC in SW|P37780|, RfbD in >emb|CAA50770.1|; dTDP-6-deoxy-L-mannose-dehydrogenase 2098630 rfbC 1078525 rfbC Shigella flexneri 2a str. 2457T dTDP-6-deoxy-L-mannose-dehydrogenase NP_837660.1 2098085 R 198215 CDS NP_837661.1 30063490 1078526 complement(2098634..2099512) 1 NC_004741.1 residues 1 to 290 of 292 are 93.79 pct identical to residues 1 to 290 of 293 from Escherichia coli K-12 : B2039; glucose-1-phosphate thymidylyltransferase 2099512 rfbA 1078526 rfbA Shigella flexneri 2a str. 2457T glucose-1-phosphate thymidylyltransferase NP_837661.1 2098634 R 198215 CDS NP_837662.1 30063491 1078509 complement(2099571..2100470) 1 NC_004741.1 with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose; dTDP-4-dehydrorhamnose reductase 2100470 rfbD 1078509 rfbD Shigella flexneri 2a str. 2457T dTDP-4-dehydrorhamnose reductase NP_837662.1 2099571 R 198215 CDS NP_837663.1 30063492 1078528 complement(2100470..2101555) 1 NC_004741.1 NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose; dTDP-glucose 4,6 dehydratase 2101555 rfbB 1078528 rfbB Shigella flexneri 2a str. 2457T dTDP-glucose 4,6 dehydratase NP_837663.1 2100470 R 198215 CDS NP_837664.1 30063493 1078506 complement(2101928..2102821) 1 NC_004741.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalF 2102821 galF 1078506 galF Shigella flexneri 2a str. 2457T UTP--glucose-1-phosphate uridylyltransferase subunit GalF NP_837664.1 2101928 R 198215 CDS NP_837665.1 30063494 1078529 complement(2102996..2104390) 1 NC_004741.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; colanic acid biosynthesis protein 2104390 wcaM 1078529 wcaM Shigella flexneri 2a str. 2457T colanic acid biosynthesis protein NP_837665.1 2102996 R 198215 CDS NP_837666.1 30063495 1077666 complement(2104401..2105621) 1 NC_004741.1 residues 1 to 406 of 406 are 97.29 pct identical to residues 1 to 406 of 406 from Escherichia coli K-12 : B2044; colanic acid biosynthesis glycosyl transferase 2105621 wcaL 1077666 wcaL Shigella flexneri 2a str. 2457T colanic acid biosynthesis glycosyl transferase NP_837666.1 2104401 R 198215 CDS NP_837667.1 30063496 1078531 complement(2105618..2106898) 1 NC_004741.1 residues 1 to 426 of 426 are 98.12 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 : B2045; pyruvyl transferase 2106898 wcaK 1078531 wcaK Shigella flexneri 2a str. 2457T pyruvyl transferase NP_837667.1 2105618 R 198215 CDS NP_837668.1 30063497 1078532 complement(2107078..2108556) 1 NC_004741.1 residues 1 to 492 of 492 are 98.57 pct identical to residues 1 to 492 of 492 from Escherichia coli K-12 : B2046; colanic acid exporter 2108556 wzxC 1078532 wzxC Shigella flexneri 2a str. 2457T colanic acid exporter NP_837668.1 2107078 R 198215 CDS NP_837669.1 30063498 1078535 complement(2108558..2109952) 1 NC_004741.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; UDP-glucose lipid carrier transferase 2109952 wcaJ 1078535 wcaJ Shigella flexneri 2a str. 2457T UDP-glucose lipid carrier transferase NP_837669.1 2108558 R 198215 CDS NP_837670.1 30063499 1078536 complement(2110007..2111377) 1 NC_004741.1 residues 1 to 456 of 456 are 99.12 pct identical to residues 1 to 456 of 456 from Escherichia coli K-12 : B2048; phosphomannomutase 2111377 cpsG 1078536 cpsG Shigella flexneri 2a str. 2457T phosphomannomutase NP_837670.1 2110007 R 198215 CDS NP_837671.1 30063500 1078231 complement(2111570..2113006) 1 NC_004741.1 residues 1 to 478 of 478 are 91.84 pct identical to residues 1 to 478 of 478 from Escherichia coli K-12 : B2049; mannose-1-phosphate guanyltransferase 2113006 cpsB 1078231 cpsB Shigella flexneri 2a str. 2457T mannose-1-phosphate guanyltransferase NP_837671.1 2111570 R 198215 CDS NP_837672.1 30063501 1078537 complement(2113009..2114232) 1 NC_004741.1 residues 1 to 407 of 407 are 95.57 pct identical to residues 1 to 407 of 407 from Escherichia coli K-12 : B2050; glycosyl transferase 2114232 wcaI 1078537 wcaI Shigella flexneri 2a str. 2457T glycosyl transferase NP_837672.1 2113009 R 198215 CDS NP_837673.1 30063502 1078538 complement(2114229..2114708) 1 NC_004741.1 residues 1 to 159 of 159 are 96.85 pct identical to residues 2 to 160 of 160 from Escherichia coli K-12 : B2051; GDP-mannose mannosyl hydrolase 2114708 wcaH 1078538 wcaH Shigella flexneri 2a str. 2457T GDP-mannose mannosyl hydrolase NP_837673.1 2114229 R 198215 CDS NP_837674.1 30063503 1076485 complement(2114708..2115676) 1 NC_004741.1 residues 1 to 321 of 322 are 98.44 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B2052; nucleotide di-P-sugar epimerase or dehydratase 2115676 wcaG 1076485 wcaG Shigella flexneri 2a str. 2457T nucleotide di-P-sugar epimerase or dehydratase NP_837674.1 2114708 R 198215 CDS NP_837675.1 30063504 1078539 complement(2115679..2116800) 1 NC_004741.1 residues 1 to 373 of 373 are 100.00 pct identical to residues 1 to 373 of 373 from Escherichia coli K-12 : B2053; GDP-D-mannose dehydratase 2116800 gmd 1078539 gmd Shigella flexneri 2a str. 2457T GDP-D-mannose dehydratase NP_837675.1 2115679 R 198215 CDS NP_837676.1 30063505 1078540 complement(2116826..2117374) 1 NC_004741.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); colanic acid biosynthesis acetyltransferase WcaF 2117374 wcaF 1078540 wcaF Shigella flexneri 2a str. 2457T colanic acid biosynthesis acetyltransferase WcaF NP_837676.1 2116826 R 198215 CDS NP_837677.1 30063506 1078542 2117570..2117845 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2117845 1078542 S2242 Shigella flexneri 2a str. 2457T IS1 orfA NP_837677.1 2117570 D 198215 CDS NP_837678.1 30063507 1078543 2117764..2118267 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 2118267 1078543 S2243 Shigella flexneri 2a str. 2457T IS1 orfB NP_837678.1 2117764 D 198215 CDS NP_837679.1 30063508 1078547 complement(2120292..2120780) 1 NC_004741.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; colanic acid biosynthesis acetyltransferase WcaB 2120780 wcaB 1078547 wcaB Shigella flexneri 2a str. 2457T colanic acid biosynthesis acetyltransferase WcaB NP_837679.1 2120292 R 198215 CDS NP_837680.2 161486469 1078551 complement(2121715..2123877) 1 NC_004741.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 2123877 1078551 S2248 Shigella flexneri 2a str. 2457T tyrosine kinase NP_837680.2 2121715 R 198215 CDS NP_837681.1 30063510 1078552 complement(2123880..2124323) 1 NC_004741.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 2124323 wzb 1078552 wzb Shigella flexneri 2a str. 2457T tyrosine phosphatase NP_837681.1 2123880 R 198215 CDS NP_837682.1 30063511 1078553 complement(2124329..2125468) 1 NC_004741.1 residues 13 to 379 of 379 are 99.72 pct identical to residues 13 to 379 of 379 from Escherichia coli K-12 : B2062; polysaccharide export protein 2125468 wza 1078553 wza Shigella flexneri 2a str. 2457T polysaccharide export protein NP_837682.1 2124329 R 198215 CDS NP_837683.1 30063512 1078554 2126127..2127710 1 NC_004741.1 residues 1 to 527 of 527 are 95.82 pct identical to residues 23 to 549 of 549 from Escherichia coli K-12 : B2063; transporter 2127710 yegH 1078554 yegH Shigella flexneri 2a str. 2457T transporter NP_837683.1 2126127 D 198215 CDS NP_837684.1 30063513 1078555 complement(2128159..2130012) 1 NC_004741.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; assembly protein 2130012 asmA 1078555 asmA Shigella flexneri 2a str. 2457T assembly protein NP_837684.1 2128159 R 198215 CDS NP_837685.1 30063514 1078006 complement(2130034..2130615) 1 NC_004741.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2130615 dcd 1078006 dcd Shigella flexneri 2a str. 2457T deoxycytidine triphosphate deaminase NP_837685.1 2130034 R 198215 CDS NP_837686.1 30063515 1078556 complement(2130707..2131348) 1 NC_004741.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 2131348 udk 1078556 udk Shigella flexneri 2a str. 2457T uridine kinase NP_837686.1 2130707 R 198215 CDS NP_837687.1 30063516 1078557 complement(2132110..2133306) 1 NC_004741.1 residues 1 to 398 of 398 are 91.20 pct identical to residues 1 to 398 of 398 from GenPept : >gb|AAL72392.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl4 orf 2133306 1078557 S2256 Shigella flexneri 2a str. 2457T ISSfl4 orf NP_837687.1 2132110 R 198215 CDS NP_837688.1 30063517 1079358 complement(2136535..2137383) 1 NC_004741.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyladenine DNA glycosylase 2137383 alkA 1079358 alkA Shigella flexneri 2a str. 2457T 3-methyladenine DNA glycosylase NP_837688.1 2136535 R 198215 CDS NP_837689.1 30063518 1078560 complement(2140818..2141579) 1 NC_004741.1 residues 1 to 251 of 253 are 90.43 pct identical to residues 1 to 251 of 253 from Escherichia coli K-12 : B2072; hypothetical protein 2141579 1078560 S2261 Shigella flexneri 2a str. 2457T hypothetical protein NP_837689.1 2140818 R 198215 CDS NP_837690.1 30063519 1078561 complement(2141576..2142235) 1 NC_004741.1 residues 1 to 219 of 219 are 90.41 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B2073; hypothetical protein 2142235 1078561 S2262 Shigella flexneri 2a str. 2457T hypothetical protein NP_837690.1 2141576 R 198215 CDS NP_837691.1 30063520 1078562 2142669..2143865 1 NC_004741.1 residues 1 to 398 of 398 are 87.43 pct identical to residues 1 to 398 of 398 from GenPept : >gb|AAL72391.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl4 orf 2143865 issfl4 1078562 issfl4 Shigella flexneri 2a str. 2457T ISSfl4 orf NP_837691.1 2142669 D 198215 CDS NP_837692.1 30063521 1078565 2148042..2151107 1 NC_004741.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2151107 yegO 1078565 yegO Shigella flexneri 2a str. 2457T multidrug efflux system subunit MdtC NP_837692.1 2148042 D 198215 CDS NP_837693.1 30063522 1078566 2151108..2152523 1 NC_004741.1 residues 1 to 471 of 471 are 85.56 pct identical to residues 1 to 471 of 471 from Escherichia coli K-12 : B2077; multidrug efflux system protein MdtE 2152523 yegB 1078566 yegB Shigella flexneri 2a str. 2457T multidrug efflux system protein MdtE NP_837693.1 2151108 D 198215 CDS NP_837694.1 30063523 1078567 2152520..2153923 1 NC_004741.1 residues 1 to 467 of 467 are 95.07 pct identical to residues 1 to 467 of 467 from Escherichia coli K-12 : B2078; signal transduction histidine-protein kinase BaeS 2153923 baeS 1078567 baeS Shigella flexneri 2a str. 2457T signal transduction histidine-protein kinase BaeS NP_837694.1 2152520 D 198215 CDS NP_837695.1 30063524 1078568 2153920..2154642 1 NC_004741.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2154642 baeR 1078568 baeR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator BaeR NP_837695.1 2153920 D 198215 CDS NP_837696.1 30063525 1078569 2154794..2155165 1 NC_004741.1 residues 1 to 123 of 123 are 98.37 pct identical to residues 1 to 123 of 123 from Escherichia coli K-12 : B2080; hypothetical protein 2155165 1078569 S2270 Shigella flexneri 2a str. 2457T hypothetical protein NP_837696.1 2154794 D 198215 CDS NP_837697.1 30063526 1078570 2155312..2156673 1 NC_004741.1 residues 1 to 453 of 453 are 96.46 pct identical to residues 1 to 453 of 453 from Escherichia coli K-12 : B2081; hypothetical protein 2156673 yegQ 1078570 yegQ Shigella flexneri 2a str. 2457T hypothetical protein NP_837697.1 2155312 D 198215 CDS NP_837698.1 30063527 1078572 complement(2157015..2157392) 1 NC_004741.1 residues 1 to 125 of 125 are 87.19 pct identical to residues 1 to 125 of 125 from Escherichia coli K-12 : B2085; hypothetical protein 2157392 1078572 S2273 Shigella flexneri 2a str. 2457T hypothetical protein NP_837698.1 2157015 R 198215 CDS NP_837699.1 30063528 1078573 2157738..2158637 1 NC_004741.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2158637 1078573 S2274 Shigella flexneri 2a str. 2457T lipid kinase NP_837699.1 2157738 D 198215 CDS NP_837700.1 30063529 1078575 complement(2158719..2159498) 1 NC_004741.1 residues 1 to 259 of 259 are 99.22 pct identical to residues 1 to 259 of 259 from NRprotein_Feb03 : >ref|NP_416591.1| Galactitol utilization operon repressor [Escherichia coli K12] sp|P36930|GATR_ECOLI Galactitol utilization operon repressor; galactitol utilization operon repressor 2159498 gatR 1078575 gatR Shigella flexneri 2a str. 2457T galactitol utilization operon repressor NP_837700.1 2158719 R 198215 CDS NP_837701.1 30063530 1078577 complement(2159598..2160638) 1 NC_004741.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 2160638 gatD 1078577 gatD Shigella flexneri 2a str. 2457T galactitol-1-phosphate dehydrogenase NP_837701.1 2159598 R 198215 CDS NP_837702.1 30063531 1078578 complement(2160671..2161174) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2161174 1078578 S2278 Shigella flexneri 2a str. 2457T IS1 orfB NP_837702.1 2160671 R 198215 CDS NP_837703.1 30063532 1078579 complement(2161093..2161368) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2161368 1078579 S2279 Shigella flexneri 2a str. 2457T IS1 orfA NP_837703.1 2161093 R 198215 CDS NP_837704.1 30063533 1079651 complement(2161463..2162818) 1 NC_004741.1 residues 1 to 451 of 451 are 91.35 pct identical to residues 1 to 451 of 451 from Escherichia coli K-12 : B2092; PTS system galactitol-specific enzyme IIC 2162818 gatC 1079651 gatC Shigella flexneri 2a str. 2457T PTS system galactitol-specific enzyme IIC NP_837704.1 2161463 R 198215 CDS NP_837705.1 30063534 1078580 complement(2162822..2163106) 1 NC_004741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; galactitol-specific PTS system component IIB 2163106 gatB 1078580 gatB Shigella flexneri 2a str. 2457T galactitol-specific PTS system component IIB NP_837705.1 2162822 R 198215 CDS NP_837706.1 30063535 1078581 complement(2163137..2163589) 1 NC_004741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; galactitol-specific PTS system component IIA 2163589 gatA 1078581 gatA Shigella flexneri 2a str. 2457T galactitol-specific PTS system component IIA NP_837706.1 2163137 R 198215 CDS NP_837707.1 30063536 1078582 complement(2163599..2164861) 1 NC_004741.1 residues 1 to 420 of 420 are 98.57 pct identical to residues 1 to 420 of 420 from Escherichia coli K-12 : B2095; tagatose 6-phosphate kinase 1 2164861 gatZ 1078582 gatZ Shigella flexneri 2a str. 2457T tagatose 6-phosphate kinase 1 NP_837707.1 2163599 R 198215 CDS NP_837708.1 30063537 1078583 complement(2164890..2165744) 1 NC_004741.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 2165744 gatY 1078583 gatY Shigella flexneri 2a str. 2457T tagatose-bisphosphate aldolase NP_837708.1 2164890 R 198215 CDS NP_837709.1 30063538 1078584 complement(2166052..2167104) 1 NC_004741.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 2167104 1078584 S2285 Shigella flexneri 2a str. 2457T fructose-bisphosphate aldolase NP_837709.1 2166052 R 198215 CDS NP_837710.1 30063539 1078586 2168144..2169109 1 NC_004741.1 residues 1 to 321 of 321 are 88.16 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B2100; kinase 2169109 1078586 S2287 Shigella flexneri 2a str. 2457T kinase NP_837710.1 2168144 D 198215 CDS NP_837711.1 30063540 1077931 complement(2169083..2169829) 1 NC_004741.1 residues 1 to 248 of 248 are 100.00 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 : B2101; transcriptional regulator 2169829 yegW 1077931 yegW Shigella flexneri 2a str. 2457T transcriptional regulator NP_837711.1 2169083 R 198215 CDS NP_837712.1 30063541 1078587 complement(2169877..2170698) 1 NC_004741.1 residues 1 to 270 of 273 are 94.44 pct identical to residues 4 to 273 of 275 from Escherichia coli K-12 : B2102; hypothetical protein 2170698 yegX 1078587 yegX Shigella flexneri 2a str. 2457T hypothetical protein NP_837712.1 2169877 R 198215 CDS NP_837713.1 30063542 1078588 complement(2170763..2171563) 1 NC_004741.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 2171563 thiD 1078588 thiD Shigella flexneri 2a str. 2457T phosphomethylpyrimidine kinase NP_837713.1 2170763 R 198215 CDS NP_837714.1 30063543 1078589 complement(2171560..2172348) 1 NC_004741.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 2172348 thiM 1078589 thiM Shigella flexneri 2a str. 2457T hydroxyethylthiazole kinase NP_837714.1 2171560 R 198215 CDS NP_837715.1 30063544 1078590 complement(2172571..2172843) 1 NC_004741.1 residues 1 to 90 of 90 are 100.00 pct identical to residues 1 to 90 of 90 from Escherichia coli K-12 : B2105; hypothetical protein 2172843 yohL 1078590 yohL Shigella flexneri 2a str. 2457T hypothetical protein NP_837715.1 2172571 R 198215 CDS NP_837716.1 30063545 1078594 complement(2175483..2177963) 1 NC_004741.1 residues 1 to 826 of 826 are 97.94 pct identical to residues 1 to 826 of 826 from Escherichia coli K-12 : B2109; outer membrane protein 2177963 yehB 1078594 yehB Shigella flexneri 2a str. 2457T outer membrane protein NP_837716.1 2175483 R 198215 CDS NP_837717.1 30063546 1078596 complement(2178734..2179258) 1 NC_004741.1 residues 1 to 174 of 174 are 85.00 pct identical to residues 1 to 180 of 180 from Escherichia coli K-12 : B2111; fimbrial-like protein 2179258 yehD 1078596 yehD Shigella flexneri 2a str. 2457T fimbrial-like protein NP_837717.1 2178734 R 198215 CDS NP_837718.1 30063547 1078597 complement(2179534..2180037) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2180037 1078597 S2299 Shigella flexneri 2a str. 2457T IS1 orfB NP_837718.1 2179534 R 198215 CDS NP_837719.1 30063548 1078598 complement(2179956..2180231) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2180231 1078598 S2300 Shigella flexneri 2a str. 2457T IS1 orfA NP_837719.1 2179956 R 198215 CDS NP_837720.1 30063549 1078599 complement(2180328..2180609) 1 NC_004741.1 residues 1 to 93 of 93 are 94.62 pct identical to residues 1 to 93 of 93 from Escherichia coli K-12 : B2112; hypothetical protein 2180609 yehE 1078599 yehE Shigella flexneri 2a str. 2457T hypothetical protein NP_837720.1 2180328 R 198215 CDS NP_837721.1 30063550 1078600 complement(2180871..2181980) 1 NC_004741.1 residues 1 to 369 of 369 are 96.47 pct identical to residues 11 to 379 of 379 from Escherichia coli K-12 : B2113; ATPase 2181980 mrp 1078600 mrp Shigella flexneri 2a str. 2457T ATPase NP_837721.1 2180871 R 198215 CDS NP_837722.1 30063551 1078601 2182112..2184145 1 NC_004741.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2184145 metG 1078601 metG Shigella flexneri 2a str. 2457T methionyl-tRNA synthetase NP_837722.1 2182112 D 198215 CDS NP_837723.1 30063552 1078608 2194722..2195876 1 NC_004741.1 residues 1 to 384 of 384 are 98.95 pct identical to residues 1 to 384 of 384 from Escherichia coli K-12 : B2119; hypothetical protein 2195876 yehL 1078608 yehL Shigella flexneri 2a str. 2457T hypothetical protein NP_837723.1 2194722 D 198215 CDS NP_837724.1 30063553 1078609 2195887..2198166 1 NC_004741.1 residues 1 to 759 of 759 are 89.32 pct identical to residues 1 to 759 of 759 from Escherichia coli K-12 : B2120; hypothetical protein 2198166 yehM 1078609 yehM Shigella flexneri 2a str. 2457T hypothetical protein NP_837724.1 2195887 D 198215 CDS NP_837725.1 30063554 1078611 2198159..2199295 1 NC_004741.1 residues 1 to 378 of 378 are 98.94 pct identical to residues 1 to 378 of 378 from Escherichia coli K-12 : B2121; hypothetical protein 2199295 yehP 1078611 yehP Shigella flexneri 2a str. 2457T hypothetical protein NP_837725.1 2198159 D 198215 CDS NP_837726.1 30063555 1078612 2199292..2201295 1 NC_004741.1 residues 1 to 615 of 667 are 87.64 pct identical to residues 9 to 622 of 622 from Escherichia coli K-12 : B2122; hypothetical protein 2201295 yehQ 1078612 yehQ Shigella flexneri 2a str. 2457T hypothetical protein NP_837726.1 2199292 D 198215 CDS NP_837727.1 30063556 1078613 complement(2201408..2201911) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2201911 1078613 S2317 Shigella flexneri 2a str. 2457T IS1 orfB NP_837727.1 2201408 R 198215 CDS NP_837728.1 30063557 1078614 complement(2201830..2202105) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2202105 1078614 S2318 Shigella flexneri 2a str. 2457T IS1 orfA NP_837728.1 2201830 R 198215 CDS NP_837729.1 30063558 1078615 2202196..2202657 1 NC_004741.1 residues 1 to 153 of 153 are 89.54 pct identical to residues 5 to 157 of 157 from Escherichia coli K-12 : B2123; hypothetical protein 2202657 yehR 1078615 yehR Shigella flexneri 2a str. 2457T hypothetical protein NP_837729.1 2202196 D 198215 CDS NP_837730.1 30063559 1078617 complement(2202878..2203381) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2203381 1078617 S2321 Shigella flexneri 2a str. 2457T IS1 orfB NP_837730.1 2202878 R 198215 CDS NP_837731.1 30063560 1078618 complement(2203300..2203575) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2203575 1078618 S2322 Shigella flexneri 2a str. 2457T IS1 orfA NP_837731.1 2203300 R 198215 CDS NP_837732.1 30063561 1078619 complement(2203991..2204710) 1 NC_004741.1 unknown function; when overproduced it confers drug-resistance; two-component response-regulatory protein YehT 2204710 yehT 1078619 yehT Shigella flexneri 2a str. 2457T two-component response-regulatory protein YehT NP_837732.1 2203991 R 198215 CDS NP_837733.1 30063562 1078620 complement(2204707..2206392) 1 NC_004741.1 residues 1 to 561 of 561 are 95.90 pct identical to residues 1 to 561 of 561 from Escherichia coli K-12 : B2126; 2-component sensor protein 2206392 yehU 1078620 yehU Shigella flexneri 2a str. 2457T 2-component sensor protein NP_837733.1 2204707 R 198215 CDS NP_837734.1 30063563 1078621 2208343..2208591 1 NC_004741.1 residues 1 to 82 of 82 are 96.34 pct identical to residues 1 to 82 of 82 from GenPept : >gb|AAG57731.1|AE005491_11 (AE005491) Z3916 gene product [Escherichia coli O157:H7 EDL933]; DNA-damage-inducible protein 2208591 1078621 S2328 Shigella flexneri 2a str. 2457T DNA-damage-inducible protein NP_837734.1 2208343 D 198215 CDS NP_837735.1 30063564 1080928 complement(2208707..2208976) 1 NC_004741.1 residues 1 to 77 of 89 are 92.20 pct identical to residues 1 to 77 of 82 from GenPept : >gb|AAG56015.1|AE005334_2 (AE005334) unknown protein encoded by prophage CP-933X [Escherichia coli O157:H7 EDL933]; hypothetical protein 2208976 1080928 S2329 Shigella flexneri 2a str. 2457T hypothetical protein NP_837735.1 2208707 R 198215 CDS NP_837736.1 30063565 1078623 complement(2211660..2212205) 1 NC_004741.1 residues 5 to 146 of 181 are 60.56 pct identical to residues 24 to 165 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein 2212205 1078623 S2331 Shigella flexneri 2a str. 2457T hypothetical protein NP_837736.1 2211660 R 198215 CDS NP_837737.1 30063566 1078624 complement(2212250..2213584) 1 NC_004741.1 residues 1 to 435 of 444 are 39.22 pct identical to residues 35 to 488 of 490 from GenPept : >emb|CAC83574.1| (AJ298298) tail fiber protein [Bacteriophage P27]; phage tail fiber protein 2213584 1078624 S2332 Shigella flexneri 2a str. 2457T phage tail fiber protein NP_837737.1 2212250 R 198215 CDS NP_837738.1 30063567 1078625 complement(2213709..2214197) 1 NC_004741.1 residues 9 to 162 of 162 are 75.97 pct identical to residues 29 to 182 of 182 from GenPept : >emb|CAC83573.1| (AJ298298) tail fiber assembly protein [Bacteriophage P27]; phage tail fiber assembly protein 2214197 1078625 S2333 Shigella flexneri 2a str. 2457T phage tail fiber assembly protein NP_837738.1 2213709 R 198215 CDS NP_837739.1 30063568 1078626 complement(2214257..2214367) 1 NC_004741.1 residues 3 to 36 of 36 are 76.47 pct identical to residues 525 to 558 of 558 from GenPept : >dbj|BAA00552.1| (D00660) Bcv gene product [Shigella boydii]; phage tail fiber protein 2214367 1078626 S2334 Shigella flexneri 2a str. 2457T phage tail fiber protein NP_837739.1 2214257 R 198215 CDS NP_837740.1 30063569 1078627 2214712..2214987 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2214987 1078627 S2335 Shigella flexneri 2a str. 2457T IS1 orfA NP_837740.1 2214712 D 198215 CDS NP_837741.1 30063570 1078628 2214906..2215409 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 B 2215409 1078628 S2336 Shigella flexneri 2a str. 2457T IS1 B NP_837741.1 2214906 D 198215 CDS NP_837742.1 30063571 1078629 2216108..2216434 1 NC_004741.1 residues 1 to 108 of 108 are 89.81 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL72412.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS629 orfA 2216434 1078629 S2337 Shigella flexneri 2a str. 2457T IS629 orfA NP_837742.1 2216108 D 198215 CDS NP_837743.1 30063572 1078630 2216670..2217317 1 NC_004741.1 residues 1 to 215 of 215 are 98.13 pct identical to residues 8 to 222 of 222 from GenPept : >gb|AAL72361.1| (AF386526) transposase [Shigella flexneri 2a]; partial; IS629 orfB 2217317 1078630 S2338 Shigella flexneri 2a str. 2457T IS629 orfB NP_837743.1 2216670 D 198215 CDS NP_837744.1 30063573 1078632 complement(2217368..2217682) 1 NC_004741.1 no significant similarities; hypothetical protein 2217682 1078632 S2340 Shigella flexneri 2a str. 2457T hypothetical protein NP_837744.1 2217368 R 198215 CDS NP_837745.1 30063574 1078633 2217875..2217982 1 NC_004741.1 residues 1 to 35 of 35 are 88.57 pct identical to residues 1 to 35 of 35 from GenPept : >gb|AAL21065.1| (AE008796) inner membrane protein [Salmonella typhimurium LT2]; hypothetical protein 2217982 1078633 S2341 Shigella flexneri 2a str. 2457T hypothetical protein NP_837745.1 2217875 D 198215 CDS NP_837746.1 30063575 1078634 complement(2217963..2218694) 1 NC_004741.1 residues 1 to 243 of 243 are 88.47 pct identical to residues 1 to 243 of 243 from Escherichia coli K-12 : B2128; transport system permease 2218694 yehW 1078634 yehW Shigella flexneri 2a str. 2457T transport system permease NP_837746.1 2217963 R 198215 CDS NP_837747.1 30063576 1078636 complement(2218699..2219625) 1 NC_004741.1 residues 1 to 308 of 308 are 94.48 pct identical to residues 1 to 308 of 308 from Escherichia coli K-12 : B2129; ATP-binding component of a transport system 2219625 yehX 1078636 yehX Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_837747.1 2218699 R 198215 CDS NP_837748.1 30063577 1078637 complement(2219618..2220775) 1 NC_004741.1 residues 1 to 385 of 385 are 77.66 pct identical to residues 1 to 385 of 385 from Escherichia coli K-12 : B2130; transport system permease 2220775 yehY 1078637 yehY Shigella flexneri 2a str. 2457T transport system permease NP_837748.1 2219618 R 198215 CDS NP_837749.1 30063578 1078214 complement(2220782..2221699) 1 NC_004741.1 residues 1 to 305 of 305 are 97.70 pct identical to residues 1 to 305 of 305 from Escherichia coli K-12 : B2131; transport system permease 2221699 yehZ 1078214 yehZ Shigella flexneri 2a str. 2457T transport system permease NP_837749.1 2220782 R 198215 CDS NP_837750.1 30063579 1078639 complement(2221951..2224248) 1 NC_004741.1 residues 1 to 765 of 765 are 99.21 pct identical to residues 1 to 765 of 765 from Escherichia coli K-12 : B2132; periplasmic; beta-D-glucoside glucohydrolase 2224248 bglX 1078639 bglX Shigella flexneri 2a str. 2457T beta-D-glucoside glucohydrolase NP_837750.1 2221951 R 198215 CDS NP_837751.1 30063580 1080942 2224444..2226159 1 NC_004741.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2226159 dld 1080942 dld Shigella flexneri 2a str. 2457T D-lactate dehydrogenase NP_837751.1 2224444 D 198215 CDS NP_837752.2 161486468 1078640 complement(2226197..2227138) 1 NC_004741.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 2227138 pbpG 1078640 pbpG Shigella flexneri 2a str. 2457T D-alanyl-D-alanine endopeptidase NP_837752.2 2226197 R 198215 CDS NP_837753.1 30063582 1078641 complement(2227303..2227890) 1 NC_004741.1 residues 1 to 195 of 195 are 92.30 pct identical to residues 9 to 203 of 203 from Escherichia coli K-12 : B2135; hypothetical protein 2227890 yohC 1078641 yohC Shigella flexneri 2a str. 2457T hypothetical protein NP_837753.1 2227303 R 198215 CDS NP_837754.1 30063583 1078642 2228024..2228638 1 NC_004741.1 residues 1 to 204 of 204 are 84.31 pct identical to residues 1 to 204 of 204 from Escherichia coli K-12 : B2136; hypothetical protein 2228638 yohD 1078642 yohD Shigella flexneri 2a str. 2457T hypothetical protein NP_837754.1 2228024 D 198215 CDS NP_837755.1 30063584 1076447 complement(2231683..2232630) 1 NC_004741.1 residues 1 to 315 of 315 are 99.36 pct identical to residues 1 to 315 of 315 from Escherichia coli K-12 : B2140; tRNA-dihydrouridine synthase C 2232630 yohI 1076447 yohI Shigella flexneri 2a str. 2457T tRNA-dihydrouridine synthase C NP_837755.1 2231683 R 198215 CDS NP_837756.1 30063585 1078646 2232869..2233267 1 NC_004741.1 residues 1 to 132 of 132 are 81.81 pct identical to residues 1 to 132 of 132 from Escherichia coli K-12 : B2141; hypothetical protein 2233267 yohJ 1078646 yohJ Shigella flexneri 2a str. 2457T hypothetical protein NP_837756.1 2232869 D 198215 CDS NP_837757.1 30063586 1078647 2233264..2233959 1 NC_004741.1 residues 1 to 231 of 231 are 93.50 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 : B2142; hypothetical protein 2233959 yohK 1078647 yohK Shigella flexneri 2a str. 2457T hypothetical protein NP_837757.1 2233264 D 198215 CDS NP_837758.1 30063587 1078648 2234089..2234973 1 NC_004741.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2234973 cdd 1078648 cdd Shigella flexneri 2a str. 2457T cytidine deaminase NP_837758.1 2234089 D 198215 CDS NP_837759.1 30063588 1078650 2235123..2235842 1 NC_004741.1 residues 1 to 239 of 239 are 92.46 pct identical to residues 1 to 239 of 239 from Escherichia coli K-12 : B2144; hypothetical protein 2235842 sanA 1078650 sanA Shigella flexneri 2a str. 2457T hypothetical protein NP_837759.1 2235123 D 198215 CDS NP_837760.1 30063589 1078651 2235845..2236084 1 NC_004741.1 residues 1 to 79 of 79 are 86.07 pct identical to residues 1 to 79 of 79 from Escherichia coli K-12 : B2145; hypothetical protein 2236084 1078651 S2359 Shigella flexneri 2a str. 2457T hypothetical protein NP_837760.1 2235845 D 198215 CDS NP_837761.1 30063590 1076429 2236278..2237516 1 NC_004741.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 2237516 1076429 S2360 Shigella flexneri 2a str. 2457T oxidoreductase NP_837761.1 2236278 D 198215 CDS NP_837762.1 30063591 1078653 complement(2238759..2239769) 1 NC_004741.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component 2239769 mglC 1078653 mglC Shigella flexneri 2a str. 2457T beta-methylgalactoside transporter inner membrane component NP_837762.1 2238759 R 198215 CDS NP_837763.1 30063592 1078654 complement(2239785..2241305) 1 NC_004741.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 2241305 mglA 1078654 mglA Shigella flexneri 2a str. 2457T galactose/methyl galaxtoside transporter ATP-binding protein NP_837763.1 2239785 R 198215 CDS NP_837764.1 30063593 1078655 complement(2241366..2242364) 1 NC_004741.1 residues 1 to 332 of 332 are 95.48 pct identical to residues 1 to 332 of 332 from Escherichia coli K-12 : B2150; galactose-binding transport protein; receptor for galactose taxis 2242364 mglB 1078655 mglB Shigella flexneri 2a str. 2457T galactose-binding transport protein; receptor for galactose taxis NP_837764.1 2241366 R 198215 CDS NP_837765.1 30063594 1078657 complement(2242644..2243684) 1 NC_004741.1 negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 2243684 galS 1078657 galS Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator GalS NP_837765.1 2242644 R 198215 CDS NP_837766.1 30063595 1078658 complement(2243826..2244902) 1 NC_004741.1 residues 1 to 358 of 358 are 79.74 pct identical to residues 1 to 385 of 385 from Escherichia coli K-12 : B2152; hypothetical protein 2244902 yeiB 1078658 yeiB Shigella flexneri 2a str. 2457T hypothetical protein NP_837766.1 2243826 R 198215 CDS NP_837767.1 30063596 1078659 complement(2244919..2245587) 1 NC_004741.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 2245587 folE 1078659 folE Shigella flexneri 2a str. 2457T GTP cyclohydrolase I NP_837767.1 2244919 R 198215 CDS NP_837768.1 30063597 1077856 complement(2248995..2250464) 1 NC_004741.1 residues 1 to 489 of 489 are 96.93 pct identical to residues 1 to 489 of 489 from Escherichia coli K-12 : B2156; lysine transporter 2250464 lysP 1077856 lysP Shigella flexneri 2a str. 2457T lysine transporter NP_837768.1 2248995 R 198215 CDS NP_837769.1 30063598 1078664 complement(2250670..2251551) 1 NC_004741.1 residues 1 to 293 of 293 are 93.85 pct identical to residues 1 to 293 of 293 from Escherichia coli K-12 : B2157; DNA-binding transcriptional regulator 2251551 yeiE 1078664 yeiE Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator NP_837769.1 2250670 R 198215 CDS NP_837770.1 30063599 1078665 2251650..2252699 1 NC_004741.1 residues 1 to 349 of 349 are 84.81 pct identical to residues 1 to 349 of 349 from Escherichia coli K-12 : B2158; hypothetical protein 2252699 yeiH 1078665 yeiH Shigella flexneri 2a str. 2457T hypothetical protein NP_837770.1 2251650 D 198215 CDS NP_837771.1 30063600 1078666 2252773..2253630 1 NC_004741.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2253630 nfo 1078666 nfo Shigella flexneri 2a str. 2457T endonuclease IV NP_837771.1 2252773 D 198215 CDS NP_837772.1 30063601 1078668 2253633..2254721 1 NC_004741.1 residues 1 to 362 of 362 are 97.79 pct identical to residues 1 to 362 of 362 from Escherichia coli K-12 : B2160; hypothetical protein 2254721 yeiI 1078668 yeiI Shigella flexneri 2a str. 2457T hypothetical protein NP_837772.1 2253633 D 198215 CDS NP_837773.1 30063602 1078669 complement(2254777..2256027) 1 NC_004741.1 residues 1 to 416 of 416 are 95.67 pct identical to residues 1 to 416 of 416 from Escherichia coli K-12 : B2161; transport system permease 2256027 yeiJ 1078669 yeiJ Shigella flexneri 2a str. 2457T transport system permease NP_837773.1 2254777 R 198215 CDS NP_837774.1 30063603 1078670 complement(2256127..2257068) 1 NC_004741.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 2257068 rihB 1078670 rihB Shigella flexneri 2a str. 2457T ribonucleoside hydrolase 2 NP_837774.1 2256127 R 198215 CDS NP_837775.1 30063604 1078671 2257238..2257816 1 NC_004741.1 activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2257816 yeiL 1078671 yeiL Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator YeiL NP_837775.1 2257238 D 198215 CDS NP_837776.1 30063605 1078674 complement(2257964..2259214) 1 NC_004741.1 residues 1 to 416 of 416 are 93.99 pct identical to residues 1 to 416 of 416 from Escherichia coli K-12 : B2164; transport system permease 2259214 yeiM 1078674 yeiM Shigella flexneri 2a str. 2457T transport system permease NP_837776.1 2257964 R 198215 CDS NP_837777.1 30063606 1079023 complement(2259308..2260246) 1 NC_004741.1 residues 1 to 312 of 312 are 97.75 pct identical to residues 1 to 312 of 312 from Escherichia coli K-12 : B2165; hypothetical protein 2260246 yeiN 1079023 yeiN Shigella flexneri 2a str. 2457T hypothetical protein NP_837777.1 2259308 R 198215 CDS NP_837778.1 30063607 1078675 complement(2260234..2261175) 1 NC_004741.1 residues 1 to 313 of 313 are 98.72 pct identical to residues 1 to 313 of 313 from Escherichia coli K-12 : B2166; hypothetical protein 2261175 yeiC 1078675 yeiC Shigella flexneri 2a str. 2457T hypothetical protein NP_837778.1 2260234 R 198215 CDS NP_837779.1 30063608 1078677 complement(2261599..2263290) 1 NC_004741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; fructose-specific PTS system IIBC component 2263290 fruA 1078677 fruA Shigella flexneri 2a str. 2457T fructose-specific PTS system IIBC component NP_837779.1 2261599 R 198215 CDS NP_837780.1 30063609 1078679 complement(2263307..2264245) 1 NC_004741.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 2264245 fruK 1078679 fruK Shigella flexneri 2a str. 2457T 1-phosphofructokinase NP_837780.1 2263307 R 198215 CDS NP_837781.1 30063610 1078203 complement(2264245..2265375) 1 NC_004741.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional fructose-specific PTS IIA/HPr protein 2265375 fruB 1078203 fruB Shigella flexneri 2a str. 2457T bifunctional fructose-specific PTS IIA/HPr protein NP_837781.1 2264245 R 198215 CDS NP_837782.1 30063611 1078680 2265743..2266921 1 NC_004741.1 residues 1 to 388 of 392 are 94.32 pct identical to residues 1 to 388 of 393 from Escherichia coli K-12 : B2170; transport 2266921 yeiO 1078680 yeiO Shigella flexneri 2a str. 2457T transport NP_837782.1 2265743 D 198215 CDS NP_837783.1 30063612 1079469 complement(2266915..2267418) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2267418 1079469 S2385 Shigella flexneri 2a str. 2457T IS1 orfB NP_837783.1 2266915 R 198215 CDS NP_837784.1 30063613 1078681 complement(2267337..2267612) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2267612 1078681 S2386 Shigella flexneri 2a str. 2457T IS1 orfA NP_837784.1 2267337 R 198215 CDS NP_837785.2 161486467 1079297 2268106..2268678 1 NC_004741.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2268678 yeiP 1079297 yeiP Shigella flexneri 2a str. 2457T elongation factor P NP_837785.2 2268106 D 198215 CDS NP_837786.1 30063615 1078243 2268901..2270367 1 NC_004741.1 residues 1 to 488 of 488 are 97.95 pct identical to residues 1 to 488 of 488 from Escherichia coli K-12 : B2172; oxidoreductase 2270367 yeiQ 1078243 yeiQ Shigella flexneri 2a str. 2457T oxidoreductase NP_837786.1 2268901 D 198215 CDS NP_837787.1 30063616 1078683 2270485..2271471 1 NC_004741.1 residues 1 to 328 of 328 are 96.03 pct identical to residues 1 to 328 of 328 from Escherichia coli K-12 : B2173; hypothetical protein 2271471 yeiR 1078683 yeiR Shigella flexneri 2a str. 2457T hypothetical protein NP_837787.1 2270485 D 198215 CDS NP_837788.1 30063617 1076536 2271510..2272223 1 NC_004741.1 residues 1 to 237 of 237 are 98.73 pct identical to residues 13 to 249 of 249 from Escherichia coli K-12 : B2174; hypothetical protein 2272223 1076536 S2390 Shigella flexneri 2a str. 2457T hypothetical protein NP_837788.1 2271510 D 198215 CDS NP_837789.1 30063618 1078684 2272635..2273201 1 NC_004741.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance; outer membrane lipoprotein 2273201 spr 1078684 spr Shigella flexneri 2a str. 2457T outer membrane lipoprotein NP_837789.1 2272635 D 198215 CDS NP_837790.1 30063619 1078479 2273382..2274938 1 NC_004741.1 residues 1 to 518 of 518 are 99.03 pct identical to residues 1 to 518 of 518 from Escherichia coli K-12 : B2176; hypothetical protein 2274938 rtn 1078479 rtn Shigella flexneri 2a str. 2457T hypothetical protein NP_837790.1 2273382 D 198215 CDS NP_837791.1 30063620 1078685 2275020..2276834 1 NC_004741.1 residues 1 to 604 of 604 are 98.17 pct identical to residues 3 to 606 of 606 from Escherichia coli K-12 : B2177; hypothetical protein 2276834 yejA 1078685 yejA Shigella flexneri 2a str. 2457T hypothetical protein NP_837791.1 2275020 D 198215 CDS NP_837792.1 30063621 1079658 2276835..2277929 1 NC_004741.1 residues 1 to 364 of 364 are 95.32 pct identical to residues 1 to 364 of 364 from Escherichia coli K-12 : B2178; transport system permease 2277929 yejB 1079658 yejB Shigella flexneri 2a str. 2457T transport system permease NP_837792.1 2276835 D 198215 CDS NP_837793.1 30063622 1078687 2277929..2278954 1 NC_004741.1 residues 1 to 341 of 341 are 93.84 pct identical to residues 1 to 341 of 341 from Escherichia coli K-12 : B2179; transport system permease 2278954 yejE 1078687 yejE Shigella flexneri 2a str. 2457T transport system permease NP_837793.1 2277929 D 198215 CDS NP_837794.1 30063623 1078686 2278956..2280545 1 NC_004741.1 residues 1 to 529 of 529 are 98.86 pct identical to residues 1 to 529 of 529 from Escherichia coli K-12 : B2180; ATP-binding component of a transport system 2280545 yejF 1078686 yejF Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_837794.1 2278956 D 198215 CDS NP_837795.1 30063624 1078213 complement(2280549..2280893) 1 NC_004741.1 residues 1 to 114 of 114 are 100.00 pct identical to residues 1 to 114 of 114 from Escherichia coli K-12 : B2181; hypothetical protein 2280893 yejG 1078213 yejG Shigella flexneri 2a str. 2457T hypothetical protein NP_837795.1 2280549 R 198215 CDS NP_837796.1 30063625 1078690 complement(2281226..2282416) 1 NC_004741.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system 2282416 bcr 1078690 bcr Shigella flexneri 2a str. 2457T bicyclomycin/multidrug efflux system NP_837796.1 2281226 R 198215 CDS NP_837797.1 30063626 1078689 complement(2282444..2283139) 1 NC_004741.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 2283139 rsuA 1078689 rsuA Shigella flexneri 2a str. 2457T 16S rRNA pseudouridylate synthase A NP_837797.1 2282444 R 198215 CDS NP_837798.1 30063627 1078688 2283289..2285049 1 NC_004741.1 residues 1 to 586 of 586 are 96.58 pct identical to residues 1 to 586 of 586 from Escherichia coli K-12 : B2184; ATP-dependent helicase 2285049 yejH 1078688 yejH Shigella flexneri 2a str. 2457T ATP-dependent helicase NP_837798.1 2283289 D 198215 CDS NP_837799.1 30063628 1078692 2285174..2285458 1 NC_004741.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2285458 rplY 1078692 rplY Shigella flexneri 2a str. 2457T 50S ribosomal protein L25 NP_837799.1 2285174 D 198215 CDS NP_837800.1 30063629 1078691 complement(2285597..2286604) 1 NC_004741.1 residues 1 to 335 of 335 are 92.83 pct identical to residues 1 to 335 of 335 from Escherichia coli K-12 : B2186; nucleoid-associated protein NdpA 2286604 yejK 1078691 yejK Shigella flexneri 2a str. 2457T nucleoid-associated protein NdpA NP_837800.1 2285597 R 198215 CDS NP_837801.1 30063630 1078693 2286786..2287013 1 NC_004741.1 residues 1 to 75 of 75 are 97.33 pct identical to residues 1 to 75 of 75 from Escherichia coli K-12 : B2187; hypothetical protein 2287013 yejL 1078693 yejL Shigella flexneri 2a str. 2457T hypothetical protein NP_837801.1 2286786 D 198215 CDS NP_837802.1 30063631 1078695 2287033..2288793 1 NC_004741.1 residues 1 to 586 of 586 are 93.85 pct identical to residues 1 to 586 of 586 from Escherichia coli K-12 : B2188; sulfatase 2288793 yejM 1078695 yejM Shigella flexneri 2a str. 2457T sulfatase NP_837802.1 2287033 D 198215 CDS NP_837803.1 30063632 1078694 complement(2289047..2291557) 1 NC_004741.1 residues 1 to 836 of 836 are 95.09 pct identical to residues 1 to 836 of 836 from Escherichia coli K-12 : B2190; ATP-binding component of a transport system 2291557 yejO 1078694 yejO Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_837803.1 2289047 R 198215 CDS NP_837804.1 30063633 1078698 2291958..2292605 1 NC_004741.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2292605 narP 1078698 narP Shigella flexneri 2a str. 2457T transcriptional regulator NarP NP_837804.1 2291958 D 198215 CDS NP_837805.1 30063634 1078699 complement(2292816..2293868) 1 NC_004741.1 residues 1 to 350 of 350 are 95.42 pct identical to residues 1 to 350 of 350 from Escherichia coli K-12 : B2194; subunit of heme lyase 2293868 ccmH 1078699 ccmH Shigella flexneri 2a str. 2457T subunit of heme lyase NP_837805.1 2292816 R 198215 CDS NP_837806.1 30063635 1078697 complement(2293865..2294422) 1 NC_004741.1 residues 1 to 185 of 185 are 79.45 pct identical to residues 1 to 185 of 185 from Escherichia coli K-12 : B2195; disulfide oxidoreductase 2294422 dsbE 1078697 dsbE Shigella flexneri 2a str. 2457T disulfide oxidoreductase NP_837806.1 2293865 R 198215 CDS NP_837807.1 30063636 1078702 complement(2294419..2296362) 1 NC_004741.1 residues 1 to 647 of 647 are 90.41 pct identical to residues 1 to 647 of 647 from Escherichia coli K-12 : B2196; cytochrome c-type biogenesis protein 2296362 ccmF 1078702 ccmF Shigella flexneri 2a str. 2457T cytochrome c-type biogenesis protein NP_837807.1 2294419 R 198215 CDS NP_837808.1 30063637 1078701 complement(2296359..2296838) 1 NC_004741.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 2296838 ccmE 1078701 ccmE Shigella flexneri 2a str. 2457T cytochrome c-type biogenesis protein CcmE NP_837808.1 2296359 R 198215 CDS NP_837809.1 30063638 1078700 complement(2296835..2297044) 1 NC_004741.1 residues 1 to 50 of 69 are 63.99 pct identical to residues 1 to 50 of 69 from Escherichia coli K-12 : B2198; heme exporter protein C 2297044 ccmD 1078700 ccmD Shigella flexneri 2a str. 2457T heme exporter protein C NP_837809.1 2296835 R 198215 CDS NP_837810.1 30063639 1078703 complement(2297041..2297778) 1 NC_004741.1 residues 1 to 245 of 245 are 100.00 pct identical to residues 1 to 245 of 245 from Escherichia coli K-12 : B2199; heme exporter protein C 2297778 ccmC 1078703 ccmC Shigella flexneri 2a str. 2457T heme exporter protein C NP_837810.1 2297041 R 198215 CDS NP_837811.1 30063640 1078704 complement(2297820..2298482) 1 NC_004741.1 residues 1 to 220 of 220 are 65.45 pct identical to residues 1 to 220 of 220 from Escherichia coli K-12 : B2200; heme exporter protein B, cytochrome c-type biogenesis protein 2298482 ccmB 1078704 ccmB Shigella flexneri 2a str. 2457T heme exporter protein B, cytochrome c-type biogenesis protein NP_837811.1 2297820 R 198215 CDS NP_837812.1 30063641 1078706 complement(2298479..2299102) 1 NC_004741.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 2299102 ccmA 1078706 ccmA Shigella flexneri 2a str. 2457T cytochrome c biogenesis protein CcmA NP_837812.1 2298479 R 198215 CDS NP_837813.1 30063642 1078708 complement(2299115..2299717) 1 NC_004741.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 2299717 napC 1078708 napC Shigella flexneri 2a str. 2457T cytochrome c-type protein NapC NP_837813.1 2299115 R 198215 CDS NP_837814.1 30063643 1078707 complement(2299727..2300176) 1 NC_004741.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 2300176 napB 1078707 napB Shigella flexneri 2a str. 2457T citrate reductase cytochrome c-type subunit NP_837814.1 2299727 R 198215 CDS NP_837815.1 30063644 1078705 complement(2300173..2301036) 1 NC_004741.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 2301036 napH 1078705 napH Shigella flexneri 2a str. 2457T quinol dehydrogenase membrane component NP_837815.1 2300173 R 198215 CDS NP_837816.1 30063645 1078711 complement(2301023..2301718) 1 NC_004741.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 2301718 napG 1078711 napG Shigella flexneri 2a str. 2457T quinol dehydrogenase periplasmic component NP_837816.1 2301023 R 198215 CDS NP_837817.1 30063646 1078710 complement(2301725..2304211) 1 NC_004741.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 2304211 napA 1078710 napA Shigella flexneri 2a str. 2457T nitrate reductase catalytic subunit NP_837817.1 2301725 R 198215 CDS NP_837818.1 30063647 1078709 complement(2304208..2304471) 1 NC_004741.1 residues 1 to 87 of 87 are 100.00 pct identical to residues 1 to 87 of 87 from Escherichia coli K-12 : B2207; assembly protein for periplasmic nitrate reductase 2304471 napD 1078709 napD Shigella flexneri 2a str. 2457T assembly protein for periplasmic nitrate reductase NP_837818.1 2304208 R 198215 CDS NP_837819.1 30063648 1078713 complement(2304461..2304955) 1 NC_004741.1 Predicted role in electron transfer to the periplasmic nitrate reductase NapA.; ferredoxin-type protein 2304955 napF 1078713 napF Shigella flexneri 2a str. 2457T ferredoxin-type protein NP_837819.1 2304461 R 198215 CDS NP_837820.1 30063649 1078714 2305363..2305851 1 NC_004741.1 residues 1 to 162 of 162 are 90.12 pct identical to residues 1 to 162 of 162 from Escherichia coli K-12 : B2209; ecotin 2305851 eco 1078714 eco Shigella flexneri 2a str. 2457T ecotin NP_837820.1 2305363 D 198215 CDS NP_837821.1 30063650 1078718 complement(2307815..2309458) 1 NC_004741.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding component 2309458 yojI 1078718 yojI Shigella flexneri 2a str. 2457T multidrug transporter membrane component/ATP-binding component NP_837821.1 2307815 R 198215 CDS NP_837822.1 30063651 1078717 complement(2309534..2310184) 1 NC_004741.1 residues 1 to 216 of 216 are 98.61 pct identical to residues 1 to 216 of 216 from Escherichia coli K-12 : B2212; alkylated DNA repair protein 2310184 alkB 1078717 alkB Shigella flexneri 2a str. 2457T alkylated DNA repair protein NP_837822.1 2309534 R 198215 CDS NP_837823.1 30063652 1078716 complement(2310184..2311248) 1 NC_004741.1 residues 1 to 354 of 354 are 92.37 pct identical to residues 1 to 354 of 354 from Escherichia coli K-12 : B2213; O6-methylguanine-DNA methyltransferase; transcription activator/repressor 2311248 ada 1078716 ada Shigella flexneri 2a str. 2457T O6-methylguanine-DNA methyltransferase; transcription activator/repressor NP_837823.1 2310184 R 198215 CDS NP_837824.1 30063653 1078715 complement(2311322..2312377) 1 NC_004741.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 2312377 yojL 1078715 yojL Shigella flexneri 2a str. 2457T thiamine biosynthesis lipoprotein ApbE NP_837824.1 2311322 R 198215 CDS NP_837825.1 30063654 1078720 complement(2312489..2313610) 1 NC_004741.1 allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C 2313610 ompC 1078720 ompC Shigella flexneri 2a str. 2457T outer membrane porin protein C NP_837825.1 2312489 R 198215 CDS NP_837826.1 30063655 1078722 2314348..2317020 1 NC_004741.1 residues 1 to 890 of 890 are 92.47 pct identical to residues 1 to 890 of 890 from Escherichia coli K-12 : B2216; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2317020 yojN 1078722 yojN Shigella flexneri 2a str. 2457T phosphotransfer intermediate protein in two-component regulatory system with RcsBC NP_837826.1 2314348 D 198215 CDS NP_837827.1 30063656 1078723 2317037..2317687 1 NC_004741.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2317687 rcsB 1078723 rcsB Shigella flexneri 2a str. 2457T transcriptional regulator RcsB NP_837827.1 2317037 D 198215 CDS NP_837828.1 30063657 1078721 complement(2317887..2320736) 1 NC_004741.1 residues 17 to 949 of 949 are 94.31 pct identical to residues 1 to 933 of 933 from Escherichia coli K-12 : B2218; hybrid sensory kinase in two-component regulatory system with RcsB and YojN 2320736 rcsC 1078721 rcsC Shigella flexneri 2a str. 2457T hybrid sensory kinase in two-component regulatory system with RcsB and YojN NP_837828.1 2317887 R 198215 CDS NP_837829.1 30063658 1078726 complement(2321011..2321787) 1 NC_004741.1 residues 1 to 258 of 258 are 94.18 pct identical to residues 1 to 258 of 258 from Escherichia coli K-12 : B2225; hypothetical protein 2321787 1078726 S2434 Shigella flexneri 2a str. 2457T hypothetical protein NP_837829.1 2321011 R 198215 CDS NP_837830.1 30063659 1078725 complement(2321792..2323441) 1 NC_004741.1 residues 1 to 549 of 549 are 97.08 pct identical to residues 1 to 549 of 549 from Escherichia coli K-12 : B2226; hypothetical protein 2323441 1078725 S2435 Shigella flexneri 2a str. 2457T hypothetical protein NP_837830.1 2321792 R 198215 CDS NP_837831.1 30063660 1078724 complement(2323442..2323957) 1 NC_004741.1 residues 12 to 171 of 171 are 99.37 pct identical to residues 2 to 161 of 161 from Escherichia coli K-12 : B2227; hypothetical protein 2323957 1078724 S2436 Shigella flexneri 2a str. 2457T hypothetical protein NP_837831.1 2323442 R 198215 CDS NP_837832.1 30063661 1078728 complement(2325716..2326342) 1 NC_004741.1 residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial; IS911 orfB 2326342 1078728 S2438 Shigella flexneri 2a str. 2457T IS911 orfB NP_837832.1 2325716 R 198215 CDS NP_837833.1 30063662 1078731 complement(2326582..2326884) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 2326884 1078731 S2440 Shigella flexneri 2a str. 2457T IS911 orfA NP_837833.1 2326582 R 198215 CDS NP_837834.1 30063663 1078732 complement(2329233..2329856) 1 NC_004741.1 residues 1 to 207 of 207 are 98.55 pct identical to residues 10 to 216 of 216 from Escherichia coli K-12 : B2229; hypothetical protein 2329856 1078732 S2442 Shigella flexneri 2a str. 2457T hypothetical protein NP_837834.1 2329233 R 198215 CDS NP_837835.1 30063664 1078730 complement(2331690..2334317) 1 NC_004741.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 2334317 gyrA 1078730 gyrA Shigella flexneri 2a str. 2457T DNA gyrase subunit A NP_837835.1 2331690 R 198215 CDS NP_837836.1 30063665 1078729 2334464..2335186 1 NC_004741.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2335186 ubiG 1078729 ubiG Shigella flexneri 2a str. 2457T 3-demethylubiquinone-9 3-methyltransferase NP_837836.1 2334464 D 198215 CDS NP_837837.1 30063666 1078736 2338932..2339342 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2339342 1078736 S2447 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_837837.1 2338932 D 198215 CDS NP_837838.2 161486466 1078738 2339300..2340205 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2340205 1078738 S2448 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_837838.2 2339300 D 198215 CDS NP_837839.1 30063668 1078737 2341076..2343361 1 NC_004741.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2343361 nrdA 1078737 nrdA Shigella flexneri 2a str. 2457T ribonucleotide-diphosphate reductase subunit alpha NP_837839.1 2341076 D 198215 CDS NP_837840.2 161486465 1078739 2343595..2344725 1 NC_004741.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2344725 nrdB 1078739 nrdB Shigella flexneri 2a str. 2457T ribonucleotide-diphosphate reductase subunit beta NP_837840.2 2343595 D 198215 CDS NP_837841.1 30063670 1078742 2344725..2344979 1 NC_004741.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin 2344979 yfaE 1078742 yfaE Shigella flexneri 2a str. 2457T 2Fe-2S ferredoxin NP_837841.1 2344725 D 198215 CDS NP_837842.1 30063671 1078741 complement(2345033..2345683) 1 NC_004741.1 residues 1 to 216 of 216 are 98.61 pct identical to residues 1 to 216 of 216 from Escherichia coli K-12 : B2237; hypothetical protein 2345683 inaA 1078741 inaA Shigella flexneri 2a str. 2457T hypothetical protein NP_837842.1 2345033 R 198215 CDS NP_837843.1 30063672 1078740 2345898..2346104 1 NC_004741.1 residues 1 to 68 of 68 are 97.05 pct identical to residues 1 to 68 of 68 from Escherichia coli K-12 : B2238; hypothetical protein 2346104 yfaH 1078740 yfaH Shigella flexneri 2a str. 2457T hypothetical protein NP_837843.1 2345898 D 198215 CDS NP_837844.1 30063673 1078746 complement(2346146..2347222) 1 NC_004741.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 2347222 glpQ 1078746 glpQ Shigella flexneri 2a str. 2457T glycerophosphodiester phosphodiesterase NP_837844.1 2346146 R 198215 CDS NP_837845.1 30063674 1080930 complement(2347227..2348585) 1 NC_004741.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 2348585 glpT 1080930 glpT Shigella flexneri 2a str. 2457T sn-glycerol-3-phosphate transporter NP_837845.1 2347227 R 198215 CDS NP_837846.1 30063675 1078747 2348858..2350486 1 NC_004741.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2350486 glpA 1078747 glpA Shigella flexneri 2a str. 2457T sn-glycerol-3-phosphate dehydrogenase subunit A NP_837846.1 2348858 D 198215 CDS NP_837847.1 30063676 1078744 2350476..2351735 1 NC_004741.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2351735 glpB 1078744 glpB Shigella flexneri 2a str. 2457T anaerobic glycerol-3-phosphate dehydrogenase subunit B NP_837847.1 2350476 D 198215 CDS NP_837848.1 30063677 1078743 2351732..2352922 1 NC_004741.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2352922 glpC 1078743 glpC Shigella flexneri 2a str. 2457T sn-glycerol-3-phosphate dehydrogenase subunit C NP_837848.1 2351732 D 198215 CDS NP_837849.1 30063678 1078751 2353115..2354065 1 NC_004741.1 residues 1 to 311 of 316 are 90.03 pct identical to residues 1 to 295 of 299 from Escherichia coli K-12 : B2244; hypothetical protein 2354065 yfaD 1078751 yfaD Shigella flexneri 2a str. 2457T hypothetical protein NP_837849.1 2353115 D 198215 CDS NP_837850.1 30063679 1078750 complement(2354106..2354576) 1 NC_004741.1 residues 4 to 156 of 156 are 77.77 pct identical to residues 115 to 267 of 267 from Escherichia coli K-12 : B2245; hypothetical protein 2354576 1078750 S2460 Shigella flexneri 2a str. 2457T hypothetical protein NP_837850.1 2354106 R 198215 CDS NP_837851.1 30063680 1078748 complement(2354631..2355833) 1 NC_004741.1 residues 1 to 400 of 400 are 96.24 pct identical to residues 1 to 400 of 400 from Escherichia coli K-12 : B2249; competence damage-inducible protein A 2355833 1078748 S2461 Shigella flexneri 2a str. 2457T competence damage-inducible protein A NP_837851.1 2354631 R 198215 CDS NP_837852.1 30063681 1078754 complement(2355920..2356462) 1 NC_004741.1 residues 1 to 180 of 180 are 87.77 pct identical to residues 8 to 187 of 187 from Escherichia coli K-12 : B2250; hypothetical protein 2356462 1078754 S2462 Shigella flexneri 2a str. 2457T hypothetical protein NP_837852.1 2355920 R 198215 CDS NP_837853.1 30063682 1078753 2356804..2357166 1 NC_004741.1 residues 1 to 120 of 120 are 80.00 pct identical to residues 22 to 141 of 141 from Escherichia coli K-12 : B2251; hypothetical protein 2357166 yfaO 1078753 yfaO Shigella flexneri 2a str. 2457T hypothetical protein NP_837853.1 2356804 D 198215 CDS NP_837854.1 30063683 1078752 complement(2357205..2357783) 1 NC_004741.1 residues 1 to 192 of 192 are 90.62 pct identical to residues 9 to 200 of 200 from Escherichia coli K-12 : B2252; protein induced by aluminum 2357783 ais 1078752 ais Shigella flexneri 2a str. 2457T protein induced by aluminum NP_837854.1 2357205 R 198215 CDS NP_837855.2 161486464 1078758 2358115..2359254 1 NC_004741.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2359254 1078758 S2465 Shigella flexneri 2a str. 2457T UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase NP_837855.2 2358115 D 198215 CDS NP_837856.1 30063685 1078757 2359258..2360226 1 NC_004741.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2360226 1078757 S2466 Shigella flexneri 2a str. 2457T undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase NP_837856.1 2359258 D 198215 CDS NP_837857.1 30063686 1078755 2360657..2362207 1 NC_004741.1 residues 1 to 516 of 516 are 98.83 pct identical to residues 145 to 660 of 660 from Escherichia coli K-12 : B2255; hypothetical protein 2362207 ybfG 1078755 ybfG Shigella flexneri 2a str. 2457T hypothetical protein NP_837857.1 2360657 D 198215 CDS NP_837858.1 30063687 1078760 2362204..2363094 1 NC_004741.1 residues 1 to 296 of 296 are 95.27 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 : B2256; hypothetical protein 2363094 1078760 S2468 Shigella flexneri 2a str. 2457T hypothetical protein NP_837858.1 2362204 D 198215 CDS NP_837859.1 30063688 1078763 2363094..2364746 1 NC_004741.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2364746 arnT 1078763 arnT Shigella flexneri 2a str. 2457T 4-amino-4-deoxy-L-arabinose transferase NP_837859.1 2363094 D 198215 CDS NP_837860.1 30063689 1078762 2364743..2365078 1 NC_004741.1 residues 1 to 477 of 477 are 99.16 pct identical to residues 1 to 477 of 477 from GenPept : >gb|AAC33123.1| (AF084030) sucrose hydrolase [Escherichia coli]; sucrose-6 phosphate hydrolase 2365078 1078762 S2567 Shigella flexneri 2a str. 2457T sucrose-6 phosphate hydrolase NP_837860.1 2364743 D 198215 CDS NP_837861.2 161486463 1078759 2365078..2365464 1 NC_004741.1 residues 1 to 222 of 222 are 86.03 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 : B2258; hypothetical protein 2365464 1078759 S2471 Shigella flexneri 2a str. 2457T hypothetical protein NP_837861.2 2365078 D 198215 CDS NP_837862.1 30063691 1078765 complement(2365835..2367190) 1 NC_004741.1 residues 1 to 451 of 451 are 92.90 pct identical to residues 1 to 451 of 451 from Escherichia coli K-12 : B2260; O-succinylbenzoic acid--CoA ligase 2367190 menE 1078765 menE Shigella flexneri 2a str. 2457T O-succinylbenzoic acid--CoA ligase NP_837862.1 2365835 R 198215 CDS NP_837863.1 30063692 1078764 complement(2367187..2368149) 1 NC_004741.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2368149 menC 1078764 menC Shigella flexneri 2a str. 2457T O-succinylbenzoate synthase NP_837863.1 2367187 R 198215 CDS NP_837864.1 30063693 1078768 complement(2368149..2369006) 1 NC_004741.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2369006 menB 1078768 menB Shigella flexneri 2a str. 2457T naphthoate synthase NP_837864.1 2368149 R 198215 CDS NP_837865.1 30063694 1078767 complement(2369021..2369779) 1 NC_004741.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB 2369779 yfbB 1078767 yfbB Shigella flexneri 2a str. 2457T acyl-CoA thioester hydrolase YfbB NP_837865.1 2369021 R 198215 CDS NP_837866.1 30063695 1078771 complement(2369776..2371446) 1 NC_004741.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2371446 menD 1078771 menD Shigella flexneri 2a str. 2457T 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase NP_837866.1 2369776 R 198215 CDS NP_837867.2 161486462 1076991 complement(2371535..2372830) 1 NC_004741.1 synthesizes isochorismate acid from chorismate; menaquinone-specific isochorismate synthase 2372830 menF 1076991 menF Shigella flexneri 2a str. 2457T menaquinone-specific isochorismate synthase NP_837867.2 2371535 R 198215 CDS NP_837868.1 30063697 1078770 complement(2372909..2373214) 1 NC_004741.1 residues 1 to 84 of 101 are 77.38 pct identical to residues 1 to 84 of 101 from Escherichia coli K-12 : B2266; hypothetical protein 2373214 elaB 1078770 elaB Shigella flexneri 2a str. 2457T hypothetical protein NP_837868.1 2372909 R 198215 CDS NP_837869.1 30063698 1078772 complement(2373269..2373730) 1 NC_004741.1 residues 1 to 153 of 153 are 100.00 pct identical to residues 1 to 153 of 153 from Escherichia coli K-12 : B2267; hypothetical protein 2373730 elaA 1078772 elaA Shigella flexneri 2a str. 2457T hypothetical protein NP_837869.1 2373269 R 198215 CDS NP_837870.2 161486461 1078773 2373795..2374712 1 NC_004741.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2374712 elaC 1078773 elaC Shigella flexneri 2a str. 2457T ribonuclease Z NP_837870.2 2373795 D 198215 CDS NP_837871.1 30063700 1078774 2375148..2375423 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2375423 1078774 S2482 Shigella flexneri 2a str. 2457T IS1 orfA NP_837871.1 2375148 D 198215 CDS NP_837872.1 30063701 1078735 2375342..2375845 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2375845 1078735 S2483 Shigella flexneri 2a str. 2457T IS1 orfB NP_837872.1 2375342 D 198215 CDS NP_837873.2 161486460 1078775 complement(2377618..2379075) 1 NC_004741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2379075 nuoN 1078775 nuoN Shigella flexneri 2a str. 2457T NADH dehydrogenase subunit N NP_837873.2 2377618 R 198215 CDS NP_837874.1 30063703 1078777 complement(2379082..2380611) 1 NC_004741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2380611 nuoM 1078777 nuoM Shigella flexneri 2a str. 2457T NADH dehydrogenase subunit M NP_837874.1 2379082 R 198215 CDS NP_837875.1 30063704 1078778 complement(2380775..2382616) 1 NC_004741.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2382616 nuoL 1078778 nuoL Shigella flexneri 2a str. 2457T NADH dehydrogenase subunit L NP_837875.1 2380775 R 198215 CDS NP_837876.1 30063705 1078782 complement(2382613..2382915) 1 NC_004741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 2382915 nuoK 1078782 nuoK Shigella flexneri 2a str. 2457T NADH dehydrogenase subunit K NP_837876.1 2382613 R 198215 CDS NP_837877.1 30063706 1078784 complement(2382912..2383466) 1 NC_004741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 2383466 nuoJ 1078784 nuoJ Shigella flexneri 2a str. 2457T NADH dehydrogenase subunit J NP_837877.1 2382912 R 198215 CDS NP_837878.1 30063707 1078785 complement(2383478..2384020) 1 NC_004741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 2384020 nuoI 1078785 nuoI Shigella flexneri 2a str. 2457T NADH dehydrogenase subunit I NP_837878.1 2383478 R 198215 CDS NP_837879.1 30063708 1076667 complement(2384035..2385012) 1 NC_004741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 2385012 nuoH 1076667 nuoH Shigella flexneri 2a str. 2457T NADH dehydrogenase subunit H NP_837879.1 2384035 R 198215 CDS NP_837880.1 30063709 1078783 complement(2385009..2387735) 1 NC_004741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 2387735 nuoG 1078783 nuoG Shigella flexneri 2a str. 2457T NADH dehydrogenase subunit G NP_837880.1 2385009 R 198215 CDS NP_837881.1 30063710 1078787 complement(2387788..2389125) 1 NC_004741.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 2389125 nuoF 1078787 nuoF Shigella flexneri 2a str. 2457T NADH dehydrogenase I subunit F NP_837881.1 2387788 R 198215 CDS NP_837882.1 30063711 1078788 complement(2389122..2389622) 1 NC_004741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 2389622 nuoE 1078788 nuoE Shigella flexneri 2a str. 2457T NADH dehydrogenase subunit E NP_837882.1 2389122 R 198215 CDS NP_837883.1 30063712 1076920 complement(2389625..2391427) 1 NC_004741.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D 2391427 nuoC 1076920 nuoC Shigella flexneri 2a str. 2457T bifunctional NADH:ubiquinone oxidoreductase subunit C/D NP_837883.1 2389625 R 198215 CDS NP_837884.1 30063713 1078089 complement(2391521..2392183) 1 NC_004741.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 2392183 nuoB 1078089 nuoB Shigella flexneri 2a str. 2457T NADH dehydrogenase subunit B NP_837884.1 2391521 R 198215 CDS NP_837885.1 30063714 1078789 complement(2392199..2392642) 1 NC_004741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 2392642 nuoA 1078789 nuoA Shigella flexneri 2a str. 2457T NADH dehydrogenase subunit A NP_837885.1 2392199 R 198215 CDS NP_837886.1 30063715 1078790 complement(2393273..2394211) 1 NC_004741.1 residues 1 to 312 of 312 are 91.98 pct identical to residues 1 to 312 of 312 from Escherichia coli K-12 : B2289; LysR family NADH dehydrogenase transcriptional regulator 2394211 lrhA 1078790 lrhA Shigella flexneri 2a str. 2457T LysR family NADH dehydrogenase transcriptional regulator NP_837886.1 2393273 R 198215 CDS NP_837887.1 30063716 1080077 2395130..2396347 1 NC_004741.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 2396347 1080077 S2501 Shigella flexneri 2a str. 2457T aminotransferase AlaT NP_837887.1 2395130 D 198215 CDS NP_837888.1 30063717 1078786 2396431..2397030 1 NC_004741.1 residues 1 to 199 of 199 are 98.99 pct identical to residues 1 to 199 of 199 from Escherichia coli K-12 : B2291; hypothetical protein 2397030 1078786 S2502 Shigella flexneri 2a str. 2457T hypothetical protein NP_837888.1 2396431 D 198215 CDS NP_837889.1 30063718 1076659 complement(2397089..2398921) 1 NC_004741.1 residues 1 to 610 of 610 are 90.49 pct identical to residues 1 to 610 of 610 from Escherichia coli K-12 : B2292; transporter 2398921 yfbS 1076659 yfbS Shigella flexneri 2a str. 2457T transporter NP_837889.1 2397089 R 198215 CDS NP_837890.1 30063719 1078791 complement(2399008..2399658) 1 NC_004741.1 residues 1 to 216 of 216 are 93.05 pct identical to residues 7 to 222 of 222 from Escherichia coli K-12 : B2293; phosphatase 2399658 yfbT 1078791 yfbT Shigella flexneri 2a str. 2457T phosphatase NP_837890.1 2399008 R 198215 CDS NP_837891.1 30063720 1078793 complement(2399669..2400163) 1 NC_004741.1 residues 1 to 164 of 164 are 98.78 pct identical to residues 7 to 170 of 170 from Escherichia coli K-12 : B2294; hypothetical protein 2400163 1078793 S2505 Shigella flexneri 2a str. 2457T hypothetical protein NP_837891.1 2399669 R 198215 CDS NP_837892.1 30063721 1078794 complement(2400246..2400701) 1 NC_004741.1 residues 1 to 151 of 151 are 99.33 pct identical to residues 1 to 151 of 151 from Escherichia coli K-12 : B2295; hypothetical protein 2400701 1078794 S2506 Shigella flexneri 2a str. 2457T hypothetical protein NP_837892.1 2400246 R 198215 CDS NP_837893.1 30063722 1078795 2401039..2402241 1 NC_004741.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2402241 ackA 1078795 ackA Shigella flexneri 2a str. 2457T acetate kinase NP_837893.1 2401039 D 198215 CDS NP_837894.1 30063723 1078796 2402316..2404460 1 NC_004741.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2404460 pta 1078796 pta Shigella flexneri 2a str. 2457T phosphate acetyltransferase NP_837894.1 2402316 D 198215 CDS NP_837895.2 161486459 1078797 2404650..2406170 1 NC_004741.1 residues 1 to 513 of 513 are 99.80 pct identical to residues 1 to 513 of 513 from Escherichia coli K-12 : B2298; hypothetical protein 2406170 yfcC 1078797 yfcC Shigella flexneri 2a str. 2457T hypothetical protein NP_837895.2 2404650 D 198215 CDS NP_837896.1 30063725 1076638 complement(2406203..2406745) 1 NC_004741.1 residues 1 to 180 of 180 are 91.11 pct identical to residues 1 to 180 of 180 from Escherichia coli K-12 : B2299; regulator 2406745 1076638 S2510 Shigella flexneri 2a str. 2457T regulator NP_837896.1 2406203 R 198215 CDS NP_837897.1 30063726 1078792 complement(2406803..2407354) 1 NC_004741.1 residues 1 to 183 of 183 are 97.81 pct identical to residues 2 to 184 of 184 from Escherichia coli K-12 : B2300; phosphodiesterase 2407354 yfcE 1078792 yfcE Shigella flexneri 2a str. 2457T phosphodiesterase NP_837897.1 2406803 R 198215 CDS NP_837898.1 30063727 1078800 complement(2407410..2408054) 1 NC_004741.1 residues 1 to 214 of 214 are 99.53 pct identical to residues 1 to 214 of 214 from Escherichia coli K-12 : B2301; hypothetical protein 2408054 yfcF 1078800 yfcF Shigella flexneri 2a str. 2457T hypothetical protein NP_837898.1 2407410 R 198215 CDS NP_837899.1 30063728 1078801 2408190..2408837 1 NC_004741.1 residues 1 to 215 of 215 are 99.06 pct identical to residues 1 to 215 of 215 from Escherichia coli K-12 : B2302; glutathione S-transferase 2408837 yfcG 1078801 yfcG Shigella flexneri 2a str. 2457T glutathione S-transferase NP_837899.1 2408190 D 198215 CDS NP_837900.1 30063729 1076649 2408894..2409256 1 NC_004741.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2409256 folX 1076649 folX Shigella flexneri 2a str. 2457T D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase NP_837900.1 2408894 D 198215 CDS NP_837901.1 30063730 1078799 2409277..2410170 1 NC_004741.1 residues 1 to 297 of 297 are 99.32 pct identical to residues 1 to 297 of 297 from Escherichia coli K-12 : B2304; sugar nucleotide epimerase 2410170 1078799 S2515 Shigella flexneri 2a str. 2457T sugar nucleotide epimerase NP_837901.1 2409277 D 198215 CDS NP_837902.1 30063731 1078802 complement(2410218..2411108) 1 NC_004741.1 residues 1 to 296 of 296 are 98.64 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 : B2305; hypothetical protein 2411108 yfcI 1078802 yfcI Shigella flexneri 2a str. 2457T hypothetical protein NP_837902.1 2410218 R 198215 CDS NP_837903.1 30063732 1078805 complement(2411305..2412078) 1 NC_004741.1 residues 1 to 257 of 257 are 95.71 pct identical to residues 1 to 257 of 257 from Escherichia coli K-12 : B2306; histidine/lysine/arginine/ornithine transporter subunit 2412078 hisP 1078805 hisP Shigella flexneri 2a str. 2457T histidine/lysine/arginine/ornithine transporter subunit NP_837903.1 2411305 R 198215 CDS NP_837904.1 30063733 1076645 complement(2412086..2412802) 1 NC_004741.1 residues 1 to 238 of 238 are 87.81 pct identical to residues 1 to 238 of 238 from Escherichia coli K-12 : B2307; histidine transport, membrane protein M 2412802 hisM 1076645 hisM Shigella flexneri 2a str. 2457T histidine transport, membrane protein M NP_837904.1 2412086 R 198215 CDS NP_837905.1 30063734 1078804 complement(2412799..2413485) 1 NC_004741.1 residues 1 to 228 of 228 are 89.47 pct identical to residues 1 to 228 of 228 from Escherichia coli K-12 : B2308; histidine transport system permease 2413485 hisQ 1078804 hisQ Shigella flexneri 2a str. 2457T histidine transport system permease NP_837905.1 2412799 R 198215 CDS NP_837906.1 30063735 1078806 complement(2413575..2414357) 1 NC_004741.1 residues 1 to 260 of 260 are 91.92 pct identical to residues 1 to 260 of 260 from Escherichia coli K-12 : B2309; histidine-binding periplasmic protein of high-affinity histidine transport system 2414357 hisJ 1078806 hisJ Shigella flexneri 2a str. 2457T histidine-binding periplasmic protein of high-affinity histidine transport system NP_837906.1 2413575 R 198215 CDS NP_837907.1 30063736 1078807 complement(2414578..2415360) 1 NC_004741.1 residues 1 to 260 of 260 are 91.15 pct identical to residues 1 to 260 of 260 from Escherichia coli K-12 : B2310; lysine-, arginine-, ornithine-binding periplasmic protein 2415360 argT 1078807 argT Shigella flexneri 2a str. 2457T lysine-, arginine-, ornithine-binding periplasmic protein NP_837907.1 2414578 R 198215 CDS NP_837908.1 30063737 1078672 complement(2415626..2416195) 1 NC_004741.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2416195 ubiX 1078672 ubiX Shigella flexneri 2a str. 2457T 3-octaprenyl-4-hydroxybenzoate carboxy-lyase NP_837908.1 2415626 R 198215 CDS NP_837909.1 30063738 1078808 complement(2416290..2417807) 1 NC_004741.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2417807 purF 1078808 purF Shigella flexneri 2a str. 2457T amidophosphoribosyltransferase NP_837909.1 2416290 R 198215 CDS NP_837910.1 30063739 1076655 complement(2417844..2418332) 1 NC_004741.1 membrane protein required for colicin V production; colicin V production protein 2418332 cvpA 1076655 cvpA Shigella flexneri 2a str. 2457T colicin V production protein NP_837910.1 2417844 R 198215 CDS NP_837911.2 161486458 1078812 complement(2418591..2419253) 1 NC_004741.1 residues 1 to 211 of 211 are 67.77 pct identical to residues 1 to 211 of 211 from Escherichia coli K-12 : B2314; hypothetical protein 2419253 dedD 1078812 dedD Shigella flexneri 2a str. 2457T hypothetical protein NP_837911.2 2418591 R 198215 CDS NP_837912.1 30063741 1078813 complement(2419243..2420511) 1 NC_004741.1 residues 1 to 422 of 422 are 92.89 pct identical to residues 1 to 422 of 422 from Escherichia coli K-12 : B2315; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 2420511 folC 1078813 folC Shigella flexneri 2a str. 2457T bifunctional folylpolyglutamate synthase/ dihydrofolate synthase NP_837912.1 2419243 R 198215 CDS NP_837913.1 30063742 1078815 complement(2420581..2421495) 1 NC_004741.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 2421495 accD 1078815 accD Shigella flexneri 2a str. 2457T acetyl-CoA carboxylase subunit beta NP_837913.1 2420581 R 198215 CDS NP_837914.1 30063743 1076642 complement(2421651..2422310) 1 NC_004741.1 residues 1 to 210 of 219 are 90.95 pct identical to residues 1 to 210 of 219 from Escherichia coli K-12 : B2317; hypothetical protein 2422310 dedA 1076642 dedA Shigella flexneri 2a str. 2457T hypothetical protein NP_837914.1 2421651 R 198215 CDS NP_837915.1 30063744 1078809 complement(2422393..2423205) 1 NC_004741.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2423205 truA 1078809 truA Shigella flexneri 2a str. 2457T tRNA pseudouridine synthase A NP_837915.1 2422393 R 198215 CDS NP_837916.1 30063745 1076658 complement(2423205..2424218) 1 NC_004741.1 residues 1 to 337 of 337 are 87.53 pct identical to residues 1 to 337 of 337 from Escherichia coli K-12 : B2319; semialdehyde dehydrogenase 2424218 usg 1076658 usg Shigella flexneri 2a str. 2457T semialdehyde dehydrogenase NP_837916.1 2423205 R 198215 CDS NP_837917.1 30063746 1078816 complement(2424284..2425420) 1 NC_004741.1 catalyzes the formation of 3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate from erythronate-4-phosphate; erythronate-4-phosphate dehydrogenase 2425420 pdxB 1078816 pdxB Shigella flexneri 2a str. 2457T erythronate-4-phosphate dehydrogenase NP_837917.1 2424284 R 198215 CDS NP_837918.1 30063747 1078817 2425519..2426514 1 NC_004741.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2426514 flk 1078817 flk Shigella flexneri 2a str. 2457T flagella biosynthesis regulator NP_837918.1 2425519 D 198215 CDS NP_837919.1 30063748 1076682 complement(2426511..2427689) 1 NC_004741.1 residues 1 to 392 of 392 are 83.16 pct identical to residues 1 to 392 of 392 from Escherichia coli K-12 : B2322; hypothetical protein 2427689 1076682 S2533 Shigella flexneri 2a str. 2457T hypothetical protein NP_837919.1 2426511 R 198215 CDS NP_837920.1 30063749 1078820 complement(2427944..2429185) 1 NC_004741.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2429185 fabB 1078820 fabB Shigella flexneri 2a str. 2457T 3-oxoacyl-ACP synthase NP_837920.1 2427944 R 198215 CDS NP_837921.2 161486457 1078821 2429344..2431350 1 NC_004741.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2431350 mnmC 1078821 mnmC Shigella flexneri 2a str. 2457T 5-methylaminomethyl-2-thiouridine methyltransferase NP_837921.2 2429344 D 198215 CDS NP_837922.1 30063751 1078819 complement(2431471..2431749) 1 NC_004741.1 residues 1 to 91 of 92 are 100.00 pct identical to residues 1 to 91 of 92 from Escherichia coli K-12 : B2325; hypothetical protein 2431749 1078819 S2536 Shigella flexneri 2a str. 2457T hypothetical protein NP_837922.1 2431471 R 198215 CDS NP_837923.1 30063752 1078823 complement(2431783..2432331) 1 NC_004741.1 residues 1 to 182 of 182 are 98.90 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 : B2326; transporting ATPase 2432331 1078823 S2537 Shigella flexneri 2a str. 2457T transporting ATPase NP_837923.1 2431783 R 198215 CDS NP_837924.1 30063753 1078822 complement(2432331..2433140) 1 NC_004741.1 residues 1 to 269 of 269 are 95.53 pct identical to residues 1 to 269 of 269 from Escherichia coli K-12 : B2327; hypothetical protein 2433140 yfcA 1078822 yfcA Shigella flexneri 2a str. 2457T hypothetical protein NP_837924.1 2432331 R 198215 CDS NP_837925.1 30063754 1076664 complement(2433140..2433964) 1 NC_004741.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 2433964 mepA 1076664 mepA Shigella flexneri 2a str. 2457T penicillin-insensitive murein endopeptidase NP_837925.1 2433140 R 198215 CDS NP_837926.1 30063755 1078824 complement(2433968..2435053) 1 NC_004741.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2435053 aroC 1078824 aroC Shigella flexneri 2a str. 2457T chorismate synthase NP_837926.1 2433968 R 198215 CDS NP_837927.1 30063756 1078825 complement(2435088..2436353) 1 NC_004741.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2436353 yfcB 1078825 yfcB Shigella flexneri 2a str. 2457T N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase NP_837927.1 2435088 R 198215 CDS NP_837928.1 30063757 1078826 2436186..2436737 1 NC_004741.1 residues 1 to 183 of 183 are 100.00 pct identical to residues 1 to 183 of 183 from Escherichia coli K-12 : B2331; hypothetical protein 2436737 1078826 S2541 Shigella flexneri 2a str. 2457T hypothetical protein NP_837928.1 2436186 D 198215 CDS NP_837929.1 30063758 1078834 complement(2442723..2443286) 1 NC_004741.1 residues 1 to 187 of 187 are 83.95 pct identical to residues 1 to 187 of 187 from Escherichia coli K-12 : B2339; fimbrial-like protein 2443286 1078834 S2550 Shigella flexneri 2a str. 2457T fimbrial-like protein NP_837929.1 2442723 R 198215 CDS NP_837930.1 30063759 1078835 complement(2443555..2444058) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 2444058 1078835 S2551 Shigella flexneri 2a str. 2457T IS1 orfB NP_837930.1 2443555 R 198215 CDS NP_837931.1 30063760 1078836 complement(2443977..2444252) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2444252 1078836 S2552 Shigella flexneri 2a str. 2457T IS1 orfA NP_837931.1 2443977 R 198215 CDS NP_837932.1 30063761 1078832 complement(2444747..2445232) 1 NC_004741.1 residues 1 to 161 of 161 are 99.37 pct identical to residues 1 to 161 of 161 from Escherichia coli K-12 : B2340; phosphohistidine phosphatase 2445232 1078832 S2553 Shigella flexneri 2a str. 2457T phosphohistidine phosphatase NP_837932.1 2444747 R 198215 CDS NP_837933.1 30063762 1076648 complement(2445435..2447579) 1 NC_004741.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 2447579 fadJ 1076648 fadJ Shigella flexneri 2a str. 2457T multifunctional fatty acid oxidation complex subunit alpha NP_837933.1 2445435 R 198215 CDS NP_837934.1 30063763 1078837 complement(2447579..2448889) 1 NC_004741.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 2448889 fadI 1078837 fadI Shigella flexneri 2a str. 2457T 3-ketoacyl-CoA thiolase NP_837934.1 2447579 R 198215 CDS NP_837935.1 30063764 1078838 complement(2449069..2449377) 1 NC_004741.1 residues 1 to 102 of 102 are 86.27 pct identical to residues 1 to 102 of 102 from Escherichia coli K-12 : B2343; hypothetical protein 2449377 1078838 S2556 Shigella flexneri 2a str. 2457T hypothetical protein NP_837935.1 2449069 R 198215 CDS NP_837936.1 30063765 1078839 2449725..2451065 1 NC_004741.1 residues 1 to 446 of 446 are 99.55 pct identical to residues 3 to 448 of 448 from Escherichia coli K-12 : B2344; sensitivity to phage t2; long-chain fatty acid outer membrane transporter 2451065 fadL 1078839 fadL Shigella flexneri 2a str. 2457T long-chain fatty acid outer membrane transporter NP_837936.1 2449725 D 198215 CDS NP_837937.1 30063766 1078840 2451431..2452489 1 NC_004741.1 residues 1 to 352 of 352 are 88.92 pct identical to residues 1 to 352 of 352 from Escherichia coli K-12 : B2345; hypothetical protein 2452489 1078840 S2558 Shigella flexneri 2a str. 2457T hypothetical protein NP_837937.1 2451431 D 198215 CDS NP_837938.1 30063767 1078841 complement(2452671..2453426) 1 NC_004741.1 residues 1 to 251 of 251 are 99.20 pct identical to residues 1 to 251 of 251 from Escherichia coli K-12 : B2346; lipoprotein precursor 2453426 vacJ 1078841 vacJ Shigella flexneri 2a str. 2457T lipoprotein precursor NP_837938.1 2452671 R 198215 CDS NP_837939.1 30063768 1078842 2453831..2454652 1 NC_004741.1 residues 1 to 273 of 273 are 87.17 pct identical to residues 38 to 310 of 310 from Escherichia coli K-12 : B2347; transporter 2454652 yfdC 1078842 yfdC Shigella flexneri 2a str. 2457T transporter NP_837939.1 2453831 D 198215 CDS NP_837940.1 30063769 1078844 complement(2456297..2456599) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 2456599 1078844 S2565 Shigella flexneri 2a str. 2457T IS911 orfA NP_837940.1 2456297 R 198215 CDS NP_837941.1 30063770 1078845 complement(2456580..2457185) 1 NC_004741.1 residues 1 to 191 of 201 are 90.76 pct identical to residues 7 to 201 of 439 from GenPept : >gb|AAK18553.1|AF348706_242 (AF348706) IS4 orf [Shigella flexneri]; partial; IS4 orf 2457185 1078845 S2566 Shigella flexneri 2a str. 2457T IS4 orf NP_837941.1 2456580 R 198215 CDS NP_837942.1 30063771 1078846 2457501..2458934 1 NC_004741.1 residues 1 to 111 of 111 are 79.27 pct identical to residues 1 to 111 of 111 from GenPept : >gb|AAG57389.1|AE005458_6 (AE005458) Z3516 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 2458934 1078846 S2470 Shigella flexneri 2a str. 2457T hypothetical protein NP_837942.1 2457501 D 198215 CDS NP_837943.1 30063772 1078338 complement(2458942..2460000) 1 NC_004741.1 residues 22 to 352 of 352 are 96.37 pct identical to residues 1 to 331 of 331 from GenPept : >emb|CAA57220.1| (X81461) sucrose specific repressor [Escherichia coli]; sucrose specific repressor 2460000 1078338 S2568 Shigella flexneri 2a str. 2457T sucrose specific repressor NP_837943.1 2458942 R 198215 CDS NP_837944.1 30063773 1078849 2460404..2461732 1 NC_004741.1 catalyzes the formation of pyruvate from serine; D-serine dehydratase 2461732 dsdA 1078849 dsdA Shigella flexneri 2a str. 2457T D-serine dehydratase NP_837944.1 2460404 D 198215 CDS NP_837945.1 30063774 1078852 complement(2461840..2463378) 1 NC_004741.1 residues 1 to 512 of 512 are 89.25 pct identical to residues 1 to 512 of 512 from Escherichia coli K-12 : B2367; multidrug resistance protein Y 2463378 emrY 1078852 emrY Shigella flexneri 2a str. 2457T multidrug resistance protein Y NP_837945.1 2461840 R 198215 CDS NP_837946.1 30063775 1078853 complement(2463378..2464541) 1 NC_004741.1 residues 1 to 387 of 387 are 94.83 pct identical to residues 1 to 387 of 387 from Escherichia coli K-12 : B2368; multidrug resistance protein K 2464541 emrK 1078853 emrK Shigella flexneri 2a str. 2457T multidrug resistance protein K NP_837946.1 2463378 R 198215 CDS NP_837947.1 30063776 1078854 2464957..2465571 1 NC_004741.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2465571 evgA 1078854 evgA Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator EvgA NP_837947.1 2464957 D 198215 CDS NP_837948.1 30063777 1080966 2465576..2469169 1 NC_004741.1 residues 1 to 1197 of 1197 are 94.23 pct identical to residues 1 to 1197 of 1197 from Escherichia coli K-12 : B2370; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2469169 evgS 1080966 evgS Shigella flexneri 2a str. 2457T hybrid sensory histidine kinase in two-component regulatory system with EvgA NP_837948.1 2465576 D 198215 CDS NP_837949.2 161486456 1080924 complement(2469225..2470409) 1 NC_004741.1 residues 1 to 381 of 381 are 98.42 pct identical to residues 14 to 394 of 394 from Escherichia coli K-12 : B2371; hypothetical protein 2470409 yfdE 1080924 yfdE Shigella flexneri 2a str. 2457T hypothetical protein NP_837949.2 2469225 R 198215 CDS NP_837950.1 30063779 1076616 complement(2471457..2473151) 1 NC_004741.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase 2473151 1076616 S2577 Shigella flexneri 2a str. 2457T oxalyl-CoA decarboxylase NP_837950.1 2471457 R 198215 CDS NP_837951.1 30063780 1078850 complement(2473205..2474455) 1 NC_004741.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 2474455 1078850 S2578 Shigella flexneri 2a str. 2457T formyl-coenzyme A transferase NP_837951.1 2473205 R 198215 CDS NP_837952.1 30063781 1078857 complement(2474968..2475591) 1 NC_004741.1 residues 1 to 207 of 207 are 90.99 pct identical to residues 1 to 211 of 211 from Escherichia coli K-12 : B2375; hypothetical protein 2475591 1078857 S2579 Shigella flexneri 2a str. 2457T hypothetical protein NP_837952.1 2474968 R 198215 CDS NP_837953.1 30063782 1076631 2475888..2476163 1 NC_004741.1 residues 17 to 91 of 91 are 92.00 pct identical to residues 17 to 91 of 91 from Escherichia coli K-12 : B2376; hypothetical protein 2476163 1076631 S2580 Shigella flexneri 2a str. 2457T hypothetical protein NP_837953.1 2475888 D 198215 CDS NP_837954.1 30063783 1078856 complement(2476240..2476482) 1 NC_004741.1 residues 1 to 80 of 80 are 98.75 pct identical to residues 1 to 80 of 80 from Escherichia coli K-12 : B2377; hypothetical protein 2476482 1078856 S2581 Shigella flexneri 2a str. 2457T hypothetical protein NP_837954.1 2476240 R 198215 CDS NP_837955.2 161486455 1076653 2476835..2477755 1 NC_004741.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2477755 ddg 1076653 ddg Shigella flexneri 2a str. 2457T lipid A biosynthesis palmitoleoyl acyltransferase NP_837955.2 2476835 D 198215 CDS NP_837956.1 30063785 1078858 complement(2478246..2479484) 1 NC_004741.1 residues 1 to 412 of 412 are 99.27 pct identical to residues 1 to 412 of 412 from Escherichia coli K-12 : B2379; aminotransferase 2479484 1078858 S2583 Shigella flexneri 2a str. 2457T aminotransferase NP_837956.1 2478246 R 198215 CDS NP_837957.1 30063786 1078860 2481362..2482096 1 NC_004741.1 residues 1 to 244 of 244 are 93.03 pct identical to residues 1 to 244 of 244 from Escherichia coli K-12 : B2381; 2-component transcriptional regulator 2482096 1078860 S2585 Shigella flexneri 2a str. 2457T 2-component transcriptional regulator NP_837957.1 2481362 D 198215 CDS NP_837958.1 30063787 1078861 2482109..2482681 1 NC_004741.1 residues 1 to 190 of 190 are 97.89 pct identical to residues 1 to 190 of 285 from Escherichia coli K-12 : B2382; ARAC-type regulatory protein 2482681 1078861 S2586 Shigella flexneri 2a str. 2457T ARAC-type regulatory protein NP_837958.1 2482109 D 198215 CDS NP_837959.1 30063788 1078863 complement(2482969..2485464) 1 NC_004741.1 residues 1 to 831 of 831 are 95.54 pct identical to residues 1 to 831 of 831 from Escherichia coli K-12 : B2383; PTS system enzyme IIA component, enzyme I 2485464 1078863 S2588 Shigella flexneri 2a str. 2457T PTS system enzyme IIA component, enzyme I NP_837959.1 2482969 R 198215 CDS NP_837960.1 30063789 1078865 complement(2485489..2486526) 1 NC_004741.1 metalloprotein; exoaminopeptidase 2486526 1078865 S2589 Shigella flexneri 2a str. 2457T exoaminopeptidase NP_837960.1 2485489 R 198215 CDS NP_837961.1 30063790 1079790 complement(2487624..2488871) 1 NC_004741.1 residues 1 to 415 of 415 are 93.25 pct identical to residues 1 to 415 of 415 from Escherichia coli K-12 : B2386; transporter 2488871 1079790 S2591 Shigella flexneri 2a str. 2457T transporter NP_837961.1 2487624 R 198215 CDS NP_837962.1 30063791 1078866 complement(2488893..2489219) 1 NC_004741.1 residues 1 to 108 of 108 are 88.88 pct identical to residues 1 to 108 of 108 from Escherichia coli K-12 : B2387; PTS system enzyme IIB component 2489219 1078866 S2592 Shigella flexneri 2a str. 2457T PTS system enzyme IIB component NP_837962.1 2488893 R 198215 CDS NP_837963.1 30063792 1078864 complement(2489438..2490403) 1 NC_004741.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 2490403 glk 1078864 glk Shigella flexneri 2a str. 2457T glucokinase NP_837963.1 2489438 R 198215 CDS NP_837964.1 30063793 1076686 2490607..2491863 1 NC_004741.1 residues 1 to 418 of 418 are 77.27 pct identical to residues 1 to 418 of 418 from Escherichia coli K-12 : B2389; hypothetical protein 2491863 1076686 S2594 Shigella flexneri 2a str. 2457T hypothetical protein NP_837964.1 2490607 D 198215 CDS NP_837965.1 30063794 1078867 2491978..2492304 1 NC_004741.1 residues 1 to 91 of 108 are 81.31 pct identical to residues 1 to 91 of 108 from Escherichia coli K-12 : B2390; hypothetical protein 2492304 1078867 S2595 Shigella flexneri 2a str. 2457T hypothetical protein NP_837965.1 2491978 D 198215 CDS NP_837967.1 30063796 1078869 complement(2492445..2493683) 1 NC_004741.1 residues 1 to 412 of 412 are 99.75 pct identical to residues 1 to 412 of 412 from Escherichia coli K-12 : B2392; manganese transport protein MntH 2493683 mntH 1078869 mntH Shigella flexneri 2a str. 2457T manganese transport protein MntH NP_837967.1 2492445 R 198215 CDS NP_837968.1 30063797 1078870 2494019..2495221 1 NC_004741.1 residues 1 to 400 of 400 are 90.49 pct identical to residues 1 to 400 of 400 from Escherichia coli K-12 : B2393; permease of transport system for 3 nucleosides 2495221 nupC 1078870 nupC Shigella flexneri 2a str. 2457T permease of transport system for 3 nucleosides NP_837968.1 2494019 D 198215 CDS NP_837970.1 30063799 1078875 2498017..2498361 1 NC_004741.1 residues 1 to 114 of 114 are 100.00 pct identical to residues 6 to 119 of 119 from Escherichia coli K-12 : B2398; hypothetical protein 2498361 yfeC 1078875 yfeC Shigella flexneri 2a str. 2457T hypothetical protein NP_837970.1 2498017 D 198215 CDS NP_837971.1 30063800 1078876 2498384..2498755 1 NC_004741.1 residues 1 to 123 of 123 are 99.18 pct identical to residues 8 to 130 of 130 from Escherichia coli K-12 : B2399; hypothetical protein 2498755 yfeD 1078876 yfeD Shigella flexneri 2a str. 2457T hypothetical protein NP_837971.1 2498384 D 198215 CDS NP_837972.1 30063801 1078877 complement(2498807..2500222) 1 NC_004741.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2500222 gltX 1078877 gltX Shigella flexneri 2a str. 2457T glutamyl-tRNA synthetase NP_837972.1 2498807 R 198215 CDS NP_837973.1 30063802 1078881 2501032..2501373 1 NC_004741.1 residues 16 to 88 of 88 are 41.89 pct identical to residues 14 to of 84 from Escherichia coli K-12 : B1566; hypothetical protein 2501373 flxA 1078881 flxA Shigella flexneri 2a str. 2457T hypothetical protein NP_837973.1 2501032 D 198215 CDS NP_837974.1 30063803 1078882 complement(2501364..2502290) 1 NC_004741.1 residues 1 to 308 of 308 are 88.96 pct identical to residues 1 to 308 of 308 from Escherichia coli K-12 : B2409; LYSR-type transcriptional regulator 2502290 yfeR 1078882 yfeR Shigella flexneri 2a str. 2457T LYSR-type transcriptional regulator NP_837974.1 2501364 R 198215 CDS NP_837975.1 30063804 1078883 2502380..2503378 1 NC_004741.1 residues 1 to 332 of 332 are 96.08 pct identical to residues 1 to 332 of 332 from Escherichia coli K-12 : B2410; cytochrome oxidase 2503378 yfeH 1078883 yfeH Shigella flexneri 2a str. 2457T cytochrome oxidase NP_837975.1 2502380 D 198215 CDS NP_837976.1 30063805 1078884 complement(2503595..2505610) 1 NC_004741.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2505610 ligA 1078884 ligA Shigella flexneri 2a str. 2457T NAD-dependent DNA ligase LigA NP_837976.1 2503595 R 198215 CDS NP_837977.1 30063806 1078885 complement(2505681..2506664) 1 NC_004741.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 2506664 zipA 1078885 zipA Shigella flexneri 2a str. 2457T cell division protein ZipA NP_837977.1 2505681 R 198215 CDS NP_837978.1 30063807 1078886 2506897..2507658 1 NC_004741.1 role in sulfur assimilation; sulfate transport protein CysZ 2507658 cysZ 1078886 cysZ Shigella flexneri 2a str. 2457T sulfate transport protein CysZ NP_837978.1 2506897 D 198215 CDS NP_837979.1 30063808 1078887 2507843..2508814 1 NC_004741.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2508814 cysK 1078887 cysK Shigella flexneri 2a str. 2457T cysteine synthase A NP_837979.1 2507843 D 198215 CDS NP_837980.1 30063809 1078888 2509198..2509455 1 NC_004741.1 residues 1 to 85 of 85 are 100.00 pct identical to residues 1 to 85 of 85 from Escherichia coli K-12 : B2415; phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr) 2509455 ptsH 1078888 ptsH Shigella flexneri 2a str. 2457T phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr) NP_837980.1 2509198 D 198215 CDS NP_837981.1 30063810 1078889 2509500..2511227 1 NC_004741.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2511227 ptsI 1078889 ptsI Shigella flexneri 2a str. 2457T phosphoenolpyruvate-protein phosphotransferase NP_837981.1 2509500 D 198215 CDS NP_837982.1 30063811 1078890 2511268..2511777 1 NC_004741.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; glucose-specific PTS system component 2511777 crr 1078890 crr Shigella flexneri 2a str. 2457T glucose-specific PTS system component NP_837982.1 2511268 D 198215 CDS NP_837983.1 30063812 1078891 complement(2511819..2512670) 1 NC_004741.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 2512670 pdxK 1078891 pdxK Shigella flexneri 2a str. 2457T pyridoxal kinase NP_837983.1 2511819 R 198215 CDS NP_837984.1 30063813 1078892 2512775..2513149 1 NC_004741.1 residues 1 to 124 of 124 are 96.77 pct identical to residues 1 to 124 of 124 from Escherichia coli K-12 : B2419; hypothetical protein 2513149 yfeK 1078892 yfeK Shigella flexneri 2a str. 2457T hypothetical protein NP_837984.1 2512775 D 198215 CDS NP_837985.1 30063814 1078894 complement(2514109..2515020) 1 NC_004741.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 2515020 cysM 1078894 cysM Shigella flexneri 2a str. 2457T cysteine synthase B NP_837985.1 2514109 R 198215 CDS NP_837986.1 30063815 1078895 complement(2515154..2516251) 1 NC_004741.1 residues 1 to 365 of 365 are 99.17 pct identical to residues 1 to 365 of 365 from Escherichia coli K-12 : B2422; sulfate/thiosulfate transporter subunit 2516251 cysA 1078895 cysA Shigella flexneri 2a str. 2457T sulfate/thiosulfate transporter subunit NP_837986.1 2515154 R 198215 CDS NP_837987.1 30063816 1078896 complement(2516241..2516690) 1 NC_004741.1 residues 1 to 149 of 149 are 88.59 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B2423; sulfate transport system permease W protein 2516690 cysW 1078896 cysW Shigella flexneri 2a str. 2457T sulfate transport system permease W protein NP_837987.1 2516241 R 198215 CDS NP_837988.1 30063817 1078897 complement(2517116..2517949) 1 NC_004741.1 residues 1 to 277 of 277 are 83.03 pct identical to residues 1 to 277 of 277 from Escherichia coli K-12 : B2424; sulfate/thiosulfate transporter subunit 2517949 cysU 1078897 cysU Shigella flexneri 2a str. 2457T sulfate/thiosulfate transporter subunit NP_837988.1 2517116 R 198215 CDS NP_837989.1 30063818 1078898 complement(2517949..2518965) 1 NC_004741.1 residues 21 to 337 of 338 are 94.95 pct identical to residues 21 to 337 of 338 from Escherichia coli K-12 : B2425; thiosulfate transporter subunit 2518965 cysP 1078898 cysP Shigella flexneri 2a str. 2457T thiosulfate transporter subunit NP_837989.1 2517949 R 198215 CDS NP_837990.1 30063819 1078899 complement(2519269..2520060) 1 NC_004741.1 residues 1 to 263 of 263 are 98.85 pct identical to residues 23 to 285 of 285 from Escherichia coli K-12 : B2426; short chain dehydrogenase 2520060 ucpA 1078899 ucpA Shigella flexneri 2a str. 2457T short chain dehydrogenase NP_837990.1 2519269 R 198215 CDS NP_837991.1 30063820 1078900 complement(2520247..2521047) 1 NC_004741.1 residues 1 to 264 of 266 are 96.96 pct identical to residues 1 to 264 of 285 from Escherichia coli K-12 : B2427; hypothetical protein 2521047 yfeT 1078900 yfeT Shigella flexneri 2a str. 2457T hypothetical protein NP_837991.1 2520247 R 198215 CDS NP_837992.1 30063821 1078901 2521211..2522107 1 NC_004741.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2522107 murQ 1078901 murQ Shigella flexneri 2a str. 2457T N-acetylmuramic acid-6-phosphate etherase NP_837992.1 2521211 D 198215 CDS NP_837993.1 30063822 1078902 2522111..2523535 1 NC_004741.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; N-acetylmuramic acid phosphotransfer permease 2523535 murP 1078902 murP Shigella flexneri 2a str. 2457T N-acetylmuramic acid phosphotransfer permease NP_837993.1 2522111 D 198215 CDS NP_837994.1 30063823 1078904 complement(2523715..2524614) 1 NC_004741.1 residues 1 to 299 of 299 are 99.33 pct identical to residues 10 to 308 of 308 from Escherichia coli K-12 : B2431; hypothetical protein 2524614 1078904 S2632 Shigella flexneri 2a str. 2457T hypothetical protein NP_837994.1 2523715 R 198215 CDS NP_837995.1 30063824 1078905 complement(2524710..2525285) 1 NC_004741.1 residues 1 to 191 of 191 are 99.47 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B2432; hypothetical protein 2525285 1078905 S2633 Shigella flexneri 2a str. 2457T hypothetical protein NP_837995.1 2524710 R 198215 CDS NP_837996.1 30063825 1078906 complement(2525346..2525795) 1 NC_004741.1 residues 1 to 149 of 149 are 79.19 pct identical to residues 3 to 151 of 151 from Escherichia coli K-12 : B2433; hypothetical protein 2525795 1078906 S2634 Shigella flexneri 2a str. 2457T hypothetical protein NP_837996.1 2525346 R 198215 CDS NP_837997.1 30063826 1078908 complement(2525782..2526207) 1 NC_004741.1 residues 1 to 141 of 141 are 99.29 pct identical to residues 38 to 178 of 178 from Escherichia coli K-12 : B2434; acetyltransferase 2526207 1078908 S2635 Shigella flexneri 2a str. 2457T acetyltransferase NP_837997.1 2525782 R 198215 CDS NP_837998.1 30063827 1078909 2526421..2527290 1 NC_004741.1 residues 1 to 289 of 289 are 95.15 pct identical to residues 1 to 289 of 289 from Escherichia coli K-12 : B2435; N-acetylmuramoyl-l-alanine amidase I 2527290 amiA 1078909 amiA Shigella flexneri 2a str. 2457T N-acetylmuramoyl-l-alanine amidase I NP_837998.1 2526421 D 198215 CDS NP_837999.1 30063828 1078911 complement(2528200..2528760) 1 NC_004741.1 residues 1 to 186 of 186 are 97.84 pct identical to residues 165 to 350 of 350 from Escherichia coli K-12 : B2437; ARAC-type regulatory protein 2528760 yfeG 1078911 yfeG Shigella flexneri 2a str. 2457T ARAC-type regulatory protein NP_837999.1 2528200 R 198215 CDS NP_838000.1 30063829 1078912 complement(2529298..2529798) 1 NC_004741.1 residues 1 to 166 of 166 are 80.72 pct identical to residues 3 to 168 of 168 from Escherichia coli K-12 : B2438; hypothetical protein 2529798 1078912 S2639 Shigella flexneri 2a str. 2457T hypothetical protein NP_838000.1 2529298 R 198215 CDS NP_838001.1 30063830 1078913 complement(2529811..2530470) 1 NC_004741.1 residues 1 to 219 of 219 are 97.71 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B2439; hypothetical protein 2530470 1078913 S2641 Shigella flexneri 2a str. 2457T hypothetical protein NP_838001.1 2529811 R 198215 CDS NP_838002.1 30063831 1078914 2531823..2532224 1 NC_004741.1 no significant similarities; hypothetical protein 2532224 1078914 S2642 Shigella flexneri 2a str. 2457T hypothetical protein NP_838002.1 2531823 D 198215 CDS NP_838003.1 30063832 1078915 2533162..2533557 1 NC_004741.1 no significant similarities; hypothetical protein 2533557 1078915 S2643 Shigella flexneri 2a str. 2457T hypothetical protein NP_838003.1 2533162 D 198215 CDS NP_838004.1 30063833 1078916 2533575..2533838 1 NC_004741.1 no significant similarities; hypothetical protein 2533838 1078916 S2644 Shigella flexneri 2a str. 2457T hypothetical protein NP_838004.1 2533575 D 198215 CDS NP_838005.1 30063834 1078917 2533861..2534403 1 NC_004741.1 no significant similarities; hypothetical protein 2534403 1078917 S2645 Shigella flexneri 2a str. 2457T hypothetical protein NP_838005.1 2533861 D 198215 CDS NP_838006.1 30063835 1078918 2534500..2534829 1 NC_004741.1 residues 44 to 105 of 109 are 36.76 pct identical to residues 14 to 81 of 81 from NRprotein_Feb2003 : >ref|NP_416939.1| orf, hypothetical protein [Escherichia coli K12] sp|P76544|YFFM_ECOLI Hypothetical protein yffM pir||C65019 hypothetical protein b2444 - Escherichia coli (strain K-12) gb|AAC75497.1| orf, hypothetical protein [Escherichia coli K12]; hypothetical protein 2534829 1078918 S2646 Shigella flexneri 2a str. 2457T hypothetical protein NP_838006.1 2534500 D 198215 CDS NP_838007.1 30063836 1078919 2534868..2535074 1 NC_004741.1 no significant similarities; hypothetical protein 2535074 1078919 S2647 Shigella flexneri 2a str. 2457T hypothetical protein NP_838007.1 2534868 D 198215 CDS NP_838008.1 30063837 1078920 2535659..2535871 1 NC_004741.1 residues 1 to 70 of 70 are 100.00 pct identical to residues 92 to 161 of 161 from GenPept : >dbj|BAA84896.1| (AB024946) orf61 [Escherichia coli]; hypothetical protein 2535871 1078920 S2648 Shigella flexneri 2a str. 2457T hypothetical protein NP_838008.1 2535659 D 198215 CDS NP_838009.1 30063838 1078921 2536123..2537583 1 NC_004741.1 residues 1 to 486 of 486 are 87.86 pct identical to residues 1 to 486 of 486 from GenPept : >dbj|BAA84897.1| (AB024946) orf62 [Escherichia coli]; amino acid antiporter 2537583 1078921 S2649 Shigella flexneri 2a str. 2457T amino acid antiporter NP_838009.1 2536123 D 198215 CDS NP_838010.1 30063839 1078922 complement(2538545..2538940) 1 NC_004741.1 residues 1 to 131 of 131 are 97.70 pct identical to residues 1 to 131 of 131 from GenPept : >dbj|BAA84899.1| (AB024946) InsB [Escherichia coli]; iso-IS1 ORF2 2538940 1078922 S2650 Shigella flexneri 2a str. 2457T iso-IS1 ORF2 NP_838010.1 2538545 R 198215 CDS NP_838011.1 30063840 1078923 complement(2538967..2539239) 1 NC_004741.1 residues 1 to 90 of 90 are 96.66 pct identical to residues 1 to 90 of 90 from GenPept : >dbj|BAA84900.1| (AB024946) InsA [Escherichia coli]; IS1N orfA 2539239 1078923 S2651 Shigella flexneri 2a str. 2457T IS1N orfA NP_838011.1 2538967 R 198215 CDS NP_838012.1 30063841 1078926 complement(2541106..2541585) 1 NC_004741.1 residues 1 to 159 of 159 are 98.11 pct identical to residues 1 to 159 of 159 from Escherichia coli K-12 : B2461; hypothetical protein 2541585 1078926 S2654 Shigella flexneri 2a str. 2457T hypothetical protein NP_838012.1 2541106 R 198215 CDS NP_838013.1 30063842 1077682 complement(2541598..2542005) 1 NC_004741.1 residues 1 to 131 of 131 are 100.00 pct identical to residues 5 to 135 of 135 from Escherichia coli K-12 : B2462; hypothetical protein 2542005 1077682 S2655 Shigella flexneri 2a str. 2457T hypothetical protein NP_838013.1 2541598 R 198215 CDS NP_838014.1 30063843 1078927 complement(2542226..2544505) 1 NC_004741.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 2544505 1078927 S2656 Shigella flexneri 2a str. 2457T malic enzyme NP_838014.1 2542226 R 198215 CDS NP_838015.1 30063844 1078928 2544794..2545744 1 NC_004741.1 Maintains the balance of metabolites in the pentose-phosphate pathway; transaldolase A 2545744 talA 1078928 talA Shigella flexneri 2a str. 2457T transaldolase A NP_838015.1 2544794 D 198215 CDS NP_838016.1 30063845 1078929 2545764..2547767 1 NC_004741.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2547767 tktB 1078929 tktB Shigella flexneri 2a str. 2457T transketolase NP_838016.1 2545764 D 198215 CDS NP_838017.1 30063846 1078930 complement(2547870..2548913) 1 NC_004741.1 residues 1 to 347 of 347 are 98.84 pct identical to residues 1 to 347 of 347 from Escherichia coli K-12 : B2466; hypothetical protein 2548913 1078930 S2659 Shigella flexneri 2a str. 2457T hypothetical protein NP_838017.1 2547870 R 198215 CDS NP_838018.1 30063847 1078931 complement(2549039..2549614) 1 NC_004741.1 residues 1 to 191 of 191 are 97.90 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B2467; hypothetical protein 2549614 yffH 1078931 yffH Shigella flexneri 2a str. 2457T hypothetical protein NP_838018.1 2549039 R 198215 CDS NP_838019.1 30063848 1078932 complement(2549682..2551661) 1 NC_004741.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit 2551661 yffG 1078932 yffG Shigella flexneri 2a str. 2457T oxidoreductase Fe-S binding subunit NP_838019.1 2549682 R 198215 CDS NP_838020.1 30063849 1078934 2553786..2556899 1 NC_004741.1 residues 1 to 1037 of 1037 are 97.01 pct identical to residues 1 to 1037 of 1037 from Escherichia coli K-12 : B2470; acriflavine resistance, integral membrane protein, possible efflux pump; aminoglycoside/multidrug efflux system 2556899 acrD 1078934 acrD Shigella flexneri 2a str. 2457T aminoglycoside/multidrug efflux system NP_838020.1 2553786 D 198215 CDS NP_838021.1 30063850 1078935 2557438..2557794 1 NC_004741.1 residues 1 to 118 of 118 are 98.30 pct identical to residues 1 to 118 of 118 from Escherichia coli K-12 : B2471; hypothetical protein 2557794 yffB 1078935 yffB Shigella flexneri 2a str. 2457T hypothetical protein NP_838021.1 2557438 D 198215 CDS NP_838022.1 30063851 1078936 2557798..2558925 1 NC_004741.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2558925 dapE 1078936 dapE Shigella flexneri 2a str. 2457T succinyl-diaminopimelate desuccinylase NP_838022.1 2557798 D 198215 CDS NP_838023.1 30063852 1078937 complement(2559263..2559961) 1 NC_004741.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH 2559961 ypfH 1078937 ypfH Shigella flexneri 2a str. 2457T esterase YpfH NP_838023.1 2559263 R 198215 CDS NP_838024.1 30063853 1078938 complement(2560035..2562050) 1 NC_004741.1 residues 1 to 671 of 671 are 88.07 pct identical to residues 1 to 671 of 671 from Escherichia coli K-12 : B2474; hypothetical protein 2562050 ypfI 1078938 ypfI Shigella flexneri 2a str. 2457T hypothetical protein NP_838024.1 2560035 R 198215 CDS NP_838025.1 30063854 1078939 complement(2562065..2562928) 1 NC_004741.1 residues 1 to 287 of 287 are 89.89 pct identical to residues 1 to 287 of 287 from Escherichia coli K-12 : B2475; hypothetical protein 2562928 1078939 S2668 Shigella flexneri 2a str. 2457T hypothetical protein NP_838025.1 2562065 R 198215 CDS NP_838026.1 30063855 1078940 complement(2563096..2563809) 1 NC_004741.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 2563809 purC 1078940 purC Shigella flexneri 2a str. 2457T phosphoribosylaminoimidazole-succinocarboxamide synthase NP_838026.1 2563096 R 198215 CDS NP_838027.1 30063856 1078941 complement(2564022..2565056) 1 NC_004741.1 residues 1 to 344 of 344 are 84.88 pct identical to residues 2 to 345 of 345 from Escherichia coli K-12 : B2477; lipoprotein 2565056 nlpB 1078941 nlpB Shigella flexneri 2a str. 2457T lipoprotein NP_838027.1 2564022 R 198215 CDS NP_838028.1 30063857 1078942 complement(2565073..2565951) 1 NC_004741.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2565951 dapA 1078942 dapA Shigella flexneri 2a str. 2457T dihydrodipicolinate synthase NP_838028.1 2565073 R 198215 CDS NP_838029.1 30063858 1078944 2566669..2567139 1 NC_004741.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2567139 bcp 1078944 bcp Shigella flexneri 2a str. 2457T thioredoxin-dependent thiol peroxidase NP_838029.1 2566669 D 198215 CDS NP_838030.1 30063859 1078945 2567392..2568009 1 NC_004741.1 residues 1 to 204 of 205 are 98.03 pct identical to residues 14 to 217 of 218 from Escherichia coli K-12 : B2481; hydrogenase 4 Fe-S subunit 2568009 hyfA 1078945 hyfA Shigella flexneri 2a str. 2457T hydrogenase 4 Fe-S subunit NP_838030.1 2567392 D 198215 CDS NP_838031.1 30063860 1078948 2570037..2570984 1 NC_004741.1 residues 1 to 315 of 315 are 80.31 pct identical to residues 8 to 322 of 322 from Escherichia coli K-12 : B2483; hydrogenase 4 membrane subunit 2570984 hyfC 1078948 hyfC Shigella flexneri 2a str. 2457T hydrogenase 4 membrane subunit NP_838031.1 2570037 D 198215 CDS NP_838032.1 30063861 1078949 2571001..2572440 1 NC_004741.1 residues 1 to 479 of 479 are 89.35 pct identical to residues 1 to 479 of 479 from Escherichia coli K-12 : B2484; hydrogenase 4 subunit D 2572440 hyfD 1078949 hyfD Shigella flexneri 2a str. 2457T hydrogenase 4 subunit D NP_838032.1 2571001 D 198215 CDS NP_838033.1 30063862 1078950 2572452..2573102 1 NC_004741.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2573102 hyfE 1078950 hyfE Shigella flexneri 2a str. 2457T hydrogenase 4 membrane subunit NP_838033.1 2572452 D 198215 CDS NP_838034.1 30063863 1078951 2573107..2574693 1 NC_004741.1 Catalyzes the transfer of electrons from NADH to ubiquinone; hydrogenase 4 subunit F 2574693 hyfF 1078951 hyfF Shigella flexneri 2a str. 2457T hydrogenase 4 subunit F NP_838034.1 2573107 D 198215 CDS NP_838035.1 30063864 1078953 2576407..2576952 1 NC_004741.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2576952 hyfH 1078953 hyfH Shigella flexneri 2a str. 2457T hydrogenase 4 subunit H NP_838035.1 2576407 D 198215 CDS NP_838036.1 30063865 1078954 2576949..2577707 1 NC_004741.1 residues 1 to 252 of 252 are 95.23 pct identical to residues 1 to 252 of 252 from Escherichia coli K-12 : B2489; hydrogenase 4 Fe-S subunit 2577707 hyfI 1078954 hyfI Shigella flexneri 2a str. 2457T hydrogenase 4 Fe-S subunit NP_838036.1 2576949 D 198215 CDS NP_838037.1 30063866 1078955 2577637..2578113 1 NC_004741.1 residues 1 to 158 of 158 are 99.36 pct identical to residues 1 to 158 of 158 from Escherichia coli K-12 : B2490; protein processing element 2578113 1078955 S2683 Shigella flexneri 2a str. 2457T protein processing element NP_838037.1 2577637 D 198215 CDS NP_838038.1 30063867 1078957 complement(2581143..2582204) 1 NC_004741.1 residues 1 to 353 of 353 are 77.62 pct identical to residues 1 to 353 of 353 from Escherichia coli K-12 : B2493; permease 2582204 perM 1078957 perM Shigella flexneri 2a str. 2457T permease NP_838038.1 2581143 R 198215 CDS NP_838039.1 30063868 1078959 2582417..2583880 1 NC_004741.1 residues 1 to 487 of 487 are 94.86 pct identical to residues 1 to 487 of 487 from Escherichia coli K-12 : B2494; hypothetical protein 2583880 1078959 S2687 Shigella flexneri 2a str. 2457T hypothetical protein NP_838039.1 2582417 D 198215 CDS NP_838040.1 30063869 1078960 2583901..2584260 1 NC_004741.1 residues 1 to 119 of 119 are 98.31 pct identical to residues 1 to 119 of 119 from Escherichia coli K-12 : B2495; oxidoreductase 2584260 1078960 S2688 Shigella flexneri 2a str. 2457T oxidoreductase NP_838040.1 2583901 D 198215 CDS NP_838041.1 30063870 1078961 complement(2584393..2585139) 1 NC_004741.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 2585139 1078961 S2689 Shigella flexneri 2a str. 2457T DNA replication initiation factor NP_838041.1 2584393 R 198215 CDS NP_838042.1 30063871 1078962 complement(2585189..2586478) 1 NC_004741.1 residues 1 to 429 of 429 are 96.27 pct identical to residues 1 to 429 of 429 from Escherichia coli K-12 : B2497; uracil transporter 2586478 uraA 1078962 uraA Shigella flexneri 2a str. 2457T uracil transporter NP_838042.1 2585189 R 198215 CDS NP_838043.1 30063872 1078963 complement(2586564..2587190) 1 NC_004741.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2587190 upp 1078963 upp Shigella flexneri 2a str. 2457T uracil phosphoribosyltransferase NP_838043.1 2586564 R 198215 CDS NP_838044.1 30063873 1078964 2587499..2588551 1 NC_004741.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2588551 purM 1078964 purM Shigella flexneri 2a str. 2457T phosphoribosylaminoimidazole synthetase NP_838044.1 2587499 D 198215 CDS NP_838045.1 30063874 1078965 2588551..2589189 1 NC_004741.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2589189 purN 1078965 purN Shigella flexneri 2a str. 2457T phosphoribosylglycinamide formyltransferase NP_838045.1 2588551 D 198215 CDS NP_838046.1 30063875 1078966 2589361..2591427 1 NC_004741.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2591427 ppk 1078966 ppk Shigella flexneri 2a str. 2457T polyphosphate kinase NP_838046.1 2589361 D 198215 CDS NP_838047.1 30063876 1078967 2591432..2592973 1 NC_004741.1 residues 1 to 513 of 513 are 97.66 pct identical to residues 1 to 513 of 513 from Escherichia coli K-12 : B2502; exopolyphosphatase 2592973 ppx 1078967 ppx Shigella flexneri 2a str. 2457T exopolyphosphatase NP_838047.1 2591432 D 198215 CDS NP_838048.1 30063877 1078969 2594187..2594489 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 2594489 1078969 S2697 Shigella flexneri 2a str. 2457T IS600 orfA NP_838048.1 2594187 D 198215 CDS NP_838049.1 30063878 1078970 2594630..2595343 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 2595343 1078970 S2698 Shigella flexneri 2a str. 2457T IS600 orfB NP_838049.1 2594630 D 198215 CDS NP_838050.1 30063879 1078971 2596873..2597064 1 NC_004741.1 residues 1 to 63 of 63 are 100.00 pct identical to residues 1 to 63 of 63 from Escherichia coli K-12 : B2504; hypothetical protein 2597064 1078971 S2700 Shigella flexneri 2a str. 2457T hypothetical protein NP_838050.1 2596873 D 198215 CDS NP_838051.1 30063880 1078972 2597375..2597893 1 NC_004741.1 residues 1 to 172 of 172 are 76.16 pct identical to residues 1 to 172 of 172 from Escherichia coli K-12 : B2505; outer membrane lipoprotein 2597893 1078972 S2701 Shigella flexneri 2a str. 2457T outer membrane lipoprotein NP_838051.1 2597375 D 198215 CDS NP_838052.1 30063881 1078973 2597909..2598448 1 NC_004741.1 residues 1 to 179 of 179 are 84.91 pct identical to residues 1 to 179 of 179 from Escherichia coli K-12 : B2506; hypothetical protein 2598448 1078973 S2702 Shigella flexneri 2a str. 2457T hypothetical protein NP_838052.1 2597909 D 198215 CDS NP_838053.1 30063882 1078974 2598850..2599665 1 NC_004741.1 residues 1 to 271 of 271 are 94.09 pct identical to residues 1 to 271 of 271 from GenPept : >gb|AAK64592.1| (AY034138) dihydropteroate synthase [Vibrio cholerae]; dihydropteroate synthase 2599665 1078974 S2703 Shigella flexneri 2a str. 2457T dihydropteroate synthase NP_838053.1 2598850 D 198215 CDS NP_838054.1 30063883 1078975 2599752..2600054 1 NC_004741.1 residues 14 to 100 of 100 are 100.00 pct identical to residues 28 to 114 of 114 from GenPept : >dbj|BAB79612.1| (AB076707) orf7 [Salmonella enterica subsp. enterica serovar Choleraesuis]; phosphoglucosamine mutase 2600054 1078975 S2704 Shigella flexneri 2a str. 2457T phosphoglucosamine mutase NP_838054.1 2599752 D 198215 CDS NP_838055.1 30063884 1078976 complement(2600230..2601723) 1 NC_004741.1 residues 1 to 497 of 497 are 100.00 pct identical to residues 1 to 497 of 497 from GenPept : >gb|AAK64580.1| (AY034138) transposase [Vibrio cholerae]; transposase 2601723 1078976 S2705 Shigella flexneri 2a str. 2457T transposase NP_838055.1 2600230 R 198215 CDS NP_838056.1 30063885 1078977 complement(2601934..2602158) 1 NC_004741.1 residues 3 to 69 of 74 are 56.52 pct identical to residues 2 to 70 of 71 from GenPept : >gb|AAD21670.1| (AF133830) hypothetical protein [Shuttle vector pME6030]; hypothetical protein 2602158 1078977 S2706 Shigella flexneri 2a str. 2457T hypothetical protein NP_838056.1 2601934 R 198215 CDS NP_838057.1 30063886 1078978 complement(2602155..2602892) 1 NC_004741.1 residues 12 to 216 of 245 are 67.31 pct identical to residues 15 to 219 of 219 from GenPept : >gb|AAA26414.1| (M59825) parA [Plasmid RP4]; resolvase 2602892 parA 1078978 parA Shigella flexneri 2a str. 2457T resolvase NP_838057.1 2602155 R 198215 CDS NP_838058.1 30063887 1078979 2603040..2603372 1 NC_004741.1 residues 16 to 97 of 110 are 53.57 pct identical to residues 8 to 91 of 109 from GenPept : >gb|AAK23484.1| (AE005825) transcriptional regulator, ArsR family [Caulobacter crescentus CB15]; transcriptional regulator 2603372 1078979 S2708 Shigella flexneri 2a str. 2457T transcriptional regulator NP_838058.1 2603040 D 198215 CDS NP_838059.1 30063888 1078980 2603369..2604136 1 NC_004741.1 residues 13 to 250 of 255 are 66.39 pct identical to residues 5 to 243 of 244 from GenPept : >gb|AAK23485.1| (AE005825) arsenical resistance protein ArsH, [Caulobacter crescentus CB15]; arsenical resistance protein 2604136 1078980 S2709 Shigella flexneri 2a str. 2457T arsenical resistance protein NP_838059.1 2603369 D 198215 CDS NP_838060.1 30063889 1078981 2604133..2604639 1 NC_004741.1 residues 1 to 165 of 168 are 54.54 pct identical to residues 1 to 165 of 169 from GenPept : >dbj|BAB50737.1| (AP003003) arsenate reductase [Mesorhizobium loti]; arsenate reductase 2604639 1078981 S2710 Shigella flexneri 2a str. 2457T arsenate reductase NP_838060.1 2604133 D 198215 CDS NP_838061.1 30063890 1078982 2604636..2605703 1 NC_004741.1 residues 17 to 353 of 355 are 65.68 pct identical to residues 1 to 338 of 352 from GenPept : >gb|AAL42497.1| (AE009108) sodium bile acid symporter family protein [Agrobacterium tumefaciens str. C58 (U. Washington)]; sodium bile acid symporter family protein 2605703 1078982 S2711 Shigella flexneri 2a str. 2457T sodium bile acid symporter family protein NP_838061.1 2604636 D 198215 CDS NP_838062.1 30063891 1078983 complement(2606599..2607087) 1 NC_004741.1 no significant similarities; hypothetical protein 2607087 1078983 S2715 Shigella flexneri 2a str. 2457T hypothetical protein NP_838062.1 2606599 R 198215 CDS NP_838063.1 30063892 1078984 complement(2607237..2608043) 1 NC_004741.1 residues 8 to 267 of 268 are 42.69 pct identical to residues 3 to 252 of 528 from GenPept : >gb|AAA26438.1| (M93696) trbL [Plasmid RP4]; mating pair formation protein 2608043 trbL 1078984 trbL Shigella flexneri 2a str. 2457T mating pair formation protein NP_838063.1 2607237 R 198215 CDS NP_838064.1 30063893 1078985 complement(2608282..2609061) 1 NC_004741.1 residues 28 to 259 of 259 are 52.58 pct identical to residues 26 to 257 of 257 from GenPept : >emb|CAD24376.1| (AJ431260) TrbJ protein [uncultured bacterium]; conjugal transfer protein TrbJ 2609061 trbJ 1078985 trbJ Shigella flexneri 2a str. 2457T conjugal transfer protein TrbJ NP_838064.1 2608282 R 198215 CDS NP_838065.1 30063894 1078986 complement(2609202..2609390) 1 NC_004741.1 residues 1 to 61 of 62 are 54.41 pct identical to residues 3 to 70 of 86 from GenPept : >gb|AAF84399.1|AE003987_3 (AE003987) plasmid stabilization protein [Xylella fastidiosa 9a5c]; stabilization protein 2609390 1078986 S2719 Shigella flexneri 2a str. 2457T stabilization protein NP_838065.1 2609202 R 198215 CDS NP_838066.1 30063895 1078987 complement(2610423..2611304) 1 NC_004741.1 residues 6 to 293 of 293 are 61.35 pct identical to residues 13 to 299 of 299 from GenPept : >gb|AAA27382.1| (M73777) replication protein C [Plasmid pTF-FC2]; replication protein C 2611304 repC 1078987 repC Shigella flexneri 2a str. 2457T replication protein C NP_838066.1 2610423 R 198215 CDS NP_838067.1 30063896 1078988 complement(2611291..2612118) 1 NC_004741.1 residues 3 to 275 of 275 are 81.68 pct identical to residues 7 to 279 of 279 from GenPept : >emb|CAC20104.1| (Y19120) replication protein A [Dichelobacter nodosus]; DNA helicase 2612118 1078988 S2721 Shigella flexneri 2a str. 2457T DNA helicase NP_838067.1 2611291 R 198215 CDS NP_838068.1 30063897 1078989 complement(2612123..2612344) 1 NC_004741.1 no significant similarities; hypothetical protein 2612344 1078989 S2722 Shigella flexneri 2a str. 2457T hypothetical protein NP_838068.1 2612123 R 198215 CDS NP_838069.1 30063898 1078990 complement(2612492..2613694) 1 NC_004741.1 residues 1 to 396 of 400 are 57.43 pct identical to residues 3 to 399 of 420 from GenPept : >dbj|BAB53138.1| (AP003010) CP4-like integrase [Mesorhizobium loti]; integrase 2613694 1078990 S2723 Shigella flexneri 2a str. 2457T integrase NP_838069.1 2612492 R 198215 CDS NP_838070.1 30063899 1078991 complement(2613999..2615576) 1 NC_004741.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 2615576 guaA 1078991 guaA Shigella flexneri 2a str. 2457T GMP synthase NP_838070.1 2613999 R 198215 CDS NP_838071.1 30063900 1078993 complement(2615645..2617111) 1 NC_004741.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2617111 guaB 1078993 guaB Shigella flexneri 2a str. 2457T inosine 5'-monophosphate dehydrogenase NP_838071.1 2615645 R 198215 CDS NP_838072.1 30063901 1078994 2617273..2618643 1 NC_004741.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2618643 xseA 1078994 xseA Shigella flexneri 2a str. 2457T exodeoxyribonuclease VII large subunit NP_838072.1 2617273 D 198215 CDS NP_838073.1 30063902 1078995 complement(2618640..2618891) 1 NC_004741.1 residues 1 to 83 of 83 are 97.59 pct identical to residues 1 to 83 of 83 from Escherichia coli K-12 : B2510; hypothetical protein 2618891 1078995 S2728 Shigella flexneri 2a str. 2457T hypothetical protein NP_838073.1 2618640 R 198215 CDS NP_838074.1 30063903 1078996 complement(2618925..2620397) 1 NC_004741.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 2620397 engA 1078996 engA Shigella flexneri 2a str. 2457T GTP-binding protein EngA NP_838074.1 2618925 R 198215 CDS NP_838075.1 30063904 1078997 complement(2620515..2621693) 1 NC_004741.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL 2621693 1078997 S2730 Shigella flexneri 2a str. 2457T outer membrane protein assembly complex subunit YfgL NP_838075.1 2620515 R 198215 CDS NP_838076.1 30063905 1078998 complement(2621704..2622324) 1 NC_004741.1 residues 1 to 206 of 206 are 91.74 pct identical to residues 1 to 206 of 206 from Escherichia coli K-12 : B2513; hypothetical protein 2622324 1078998 S2731 Shigella flexneri 2a str. 2457T hypothetical protein NP_838076.1 2621704 R 198215 CDS NP_838077.1 30063906 1078999 complement(2622342..2623616) 1 NC_004741.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2623616 hisS 1078999 hisS Shigella flexneri 2a str. 2457T histidyl-tRNA synthetase NP_838077.1 2622342 R 198215 CDS NP_838078.1 30063907 1079000 complement(2623719..2624846) 1 NC_004741.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2624846 ispG 1079000 ispG Shigella flexneri 2a str. 2457T 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase NP_838078.1 2623719 R 198215 CDS NP_838079.1 30063908 1079001 complement(2624873..2625886) 1 NC_004741.1 residues 1 to 337 of 337 are 80.71 pct identical to residues 1 to 337 of 337 from Escherichia coli K-12 : B2516; hypothetical protein 2625886 yfgA 1079001 yfgA Shigella flexneri 2a str. 2457T hypothetical protein NP_838079.1 2624873 R 198215 CDS NP_838080.1 30063909 1079002 complement(2626171..2627325) 1 NC_004741.1 residues 1 to 384 of 384 are 99.47 pct identical to residues 1 to 384 of 384 from Escherichia coli K-12 : B2517; hypothetical protein 2627325 yfgB 1079002 yfgB Shigella flexneri 2a str. 2457T hypothetical protein NP_838080.1 2626171 R 198215 CDS NP_838081.1 30063910 1079003 complement(2627475..2627906) 1 NC_004741.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2627906 ndk 1079003 ndk Shigella flexneri 2a str. 2457T nucleoside diphosphate kinase NP_838081.1 2627475 R 198215 CDS NP_838082.1 30063911 1079005 complement(2630171..2631367) 1 NC_004741.1 residues 1 to 398 of 398 are 90.95 pct identical to residues 1 to 398 of 398 from GenPept : >gb|AAK18438.1|AF348706_127 (AF348706) transposase for IS110 [Shigella flexneri]; ISSfl4 orf 2631367 1079005 S2738 Shigella flexneri 2a str. 2457T ISSfl4 orf NP_838082.1 2630171 R 198215 CDS NP_838083.1 30063912 1079007 complement(2632898..2633674) 1 NC_004741.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 2633674 sseB 1079007 sseB Shigella flexneri 2a str. 2457T enhanced serine sensitivity protein SseB NP_838083.1 2632898 R 198215 CDS NP_838084.1 30063913 1079008 complement(2633816..2635099) 1 NC_004741.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B 2635099 pepB 1079008 pepB Shigella flexneri 2a str. 2457T aminopeptidase B NP_838084.1 2633816 R 198215 CDS NP_838085.1 30063914 1079010 complement(2635158..2635358) 1 NC_004741.1 residues 1 to 66 of 66 are 100.00 pct identical to residues 1 to 66 of 66 from Escherichia coli K-12 : B2524; hypothetical protein 2635358 yfhJ 1079010 yfhJ Shigella flexneri 2a str. 2457T hypothetical protein NP_838085.1 2635158 R 198215 CDS NP_838086.1 30063915 1078311 complement(2635370..2635705) 1 NC_004741.1 residues 1 to 111 of 111 are 100.00 pct identical to residues 1 to 111 of 111 from Escherichia coli K-12 : B2525; [2FE-2S] ferredoxin, electron carrer protein 2635705 fdx 1078311 fdx Shigella flexneri 2a str. 2457T [2FE-2S] ferredoxin, electron carrer protein NP_838086.1 2635370 R 198215 CDS NP_838087.1 30063916 1079011 complement(2635707..2637557) 1 NC_004741.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 2637557 hscA 1079011 hscA Shigella flexneri 2a str. 2457T chaperone protein HscA NP_838087.1 2635707 R 198215 CDS NP_838088.1 30063917 1080070 complement(2637574..2638089) 1 NC_004741.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 2638089 hscB 1080070 hscB Shigella flexneri 2a str. 2457T co-chaperone HscB NP_838088.1 2637574 R 198215 CDS NP_838089.1 30063918 1079012 complement(2638185..2638508) 1 NC_004741.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 2638508 iscA 1079012 iscA Shigella flexneri 2a str. 2457T iron-sulfur cluster assembly protein NP_838089.1 2638185 R 198215 CDS NP_838090.1 30063919 1079014 complement(2638525..2638911) 1 NC_004741.1 residues 1 to 128 of 128 are 100.00 pct identical to residues 1 to 128 of 128 from Escherichia coli K-12 : B2529; scaffold protein 2638911 1079014 S2748 Shigella flexneri 2a str. 2457T scaffold protein NP_838090.1 2638525 R 198215 CDS NP_838091.1 30063920 1079015 complement(2638939..2640153) 1 NC_004741.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 2640153 yfhO 1079015 yfhO Shigella flexneri 2a str. 2457T cysteine desulfurase NP_838091.1 2638939 R 198215 CDS NP_838092.1 30063921 1079016 complement(2640265..2640753) 1 NC_004741.1 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 2640753 1079016 S2750 Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator IscR NP_838092.1 2640265 R 198215 CDS NP_838093.1 30063922 1079018 complement(2641023..2641763) 1 NC_004741.1 residues 1 to 246 of 246 are 100.00 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B2532; ATP synthase subunit beta 2641763 1079018 S2751 Shigella flexneri 2a str. 2457T ATP synthase subunit beta NP_838093.1 2641023 R 198215 CDS NP_838094.1 30063923 1080455 2641882..2642685 1 NC_004741.1 residues 1 to 266 of 267 are 99.62 pct identical to residues 1 to 266 of 267 from Escherichia coli K-12 : B2533; inositol monophosphatase 2642685 suhB 1080455 suhB Shigella flexneri 2a str. 2457T inositol monophosphatase NP_838094.1 2641882 D 198215 CDS NP_838095.1 30063924 1079019 2642830..2643684 1 NC_004741.1 residues 1 to 284 of 284 are 98.59 pct identical to residues 10 to 293 of 293 from Escherichia coli K-12 : B2534; enzyme 2643684 1079019 S2753 Shigella flexneri 2a str. 2457T enzyme NP_838095.1 2642830 D 198215 CDS NP_838096.1 30063925 1079020 2643875..2645155 1 NC_004741.1 residues 1 to 426 of 426 are 96.47 pct identical to residues 8 to 433 of 433 from Escherichia coli K-12 : B2535; stationary phase inducible protein CsiE 2645155 csiE 1079020 csiE Shigella flexneri 2a str. 2457T stationary phase inducible protein CsiE NP_838096.1 2643875 D 198215 CDS NP_838097.1 30063926 1078286 complement(2645147..2646286) 1 NC_004741.1 transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter 2646286 hcaT 1078286 hcaT Shigella flexneri 2a str. 2457T 3-phenylpropionic acid transporter NP_838097.1 2645147 R 198215 CDS NP_838098.1 30063927 1079021 complement(2646446..2647336) 1 NC_004741.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR 2647336 hcaR 1079021 hcaR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator HcaR NP_838098.1 2646446 R 198215 CDS NP_838099.1 30063928 1078029 2647472..2648833 1 NC_004741.1 residues 1 to 453 of 453 are 99.55 pct identical to residues 1 to 453 of 453 from Escherichia coli K-12 : B2538; large terminal subunit of phenylpropionate dioxygenase 2648833 hcaA1 1078029 hcaA1 Shigella flexneri 2a str. 2457T large terminal subunit of phenylpropionate dioxygenase NP_838099.1 2647472 D 198215 CDS NP_838100.1 30063929 1079025 2648830..2649348 1 NC_004741.1 residues 1 to 172 of 172 are 99.41 pct identical to residues 1 to 172 of 172 from Escherichia coli K-12 : B2539; 3-phenylpropionate dioxygenase subunit beta 2649348 hcaA2 1079025 hcaA2 Shigella flexneri 2a str. 2457T 3-phenylpropionate dioxygenase subunit beta NP_838100.1 2648830 D 198215 CDS NP_838101.1 30063930 1079026 2649348..2649668 1 NC_004741.1 residues 1 to 106 of 106 are 100.00 pct identical to residues 1 to 106 of 106 from Escherichia coli K-12 : B2540; 3-phenylpropionate dioxygenase ferredoxin subunit 2649668 hcaC 1079026 hcaC Shigella flexneri 2a str. 2457T 3-phenylpropionate dioxygenase ferredoxin subunit NP_838101.1 2649348 D 198215 CDS NP_838102.1 30063931 1079027 2649665..2650477 1 NC_004741.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2650477 hcaB 1079027 hcaB Shigella flexneri 2a str. 2457T 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase NP_838102.1 2649665 D 198215 CDS NP_838103.1 30063932 1079028 2651734..2652228 1 NC_004741.1 residues 1 to 164 of 164 are 89.63 pct identical to residues 1 to 164 of 164 from Escherichia coli K-12 : B2543; hypothetical protein 2652228 yphA 1079028 yphA Shigella flexneri 2a str. 2457T hypothetical protein NP_838103.1 2651734 D 198215 CDS NP_838104.1 30063933 1079029 complement(2652276..2653148) 1 NC_004741.1 residues 1 to 290 of 290 are 99.31 pct identical to residues 1 to 290 of 290 from Escherichia coli K-12 : B2544; hypothetical protein 2653148 yphB 1079029 yphB Shigella flexneri 2a str. 2457T hypothetical protein NP_838104.1 2652276 R 198215 CDS NP_838105.1 30063934 1078221 complement(2653160..2654254) 1 NC_004741.1 residues 1 to 364 of 364 are 94.23 pct identical to residues 1 to 364 of 364 from Escherichia coli K-12 : B2545; oxidoreductase 2654254 yphC 1078221 yphC Shigella flexneri 2a str. 2457T oxidoreductase NP_838105.1 2653160 R 198215 CDS NP_838106.1 30063935 1079031 complement(2654287..2655285) 1 NC_004741.1 residues 1 to 332 of 332 are 75.30 pct identical to residues 1 to 332 of 332 from Escherichia coli K-12 : B2546; transport system permease 2655285 yphD 1079031 yphD Shigella flexneri 2a str. 2457T transport system permease NP_838106.1 2654287 R 198215 CDS NP_838107.1 30063936 1079032 complement(2655310..2656821) 1 NC_004741.1 residues 1 to 503 of 503 are 99.00 pct identical to residues 1 to 503 of 503 from Escherichia coli K-12 : B2547; ATP-binding component of a transport system 2656821 yphE 1079032 yphE Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_838107.1 2655310 R 198215 CDS NP_838108.1 30063937 1079034 2661322..2662515 1 NC_004741.1 residues 1 to 397 of 397 are 98.48 pct identical to residues 3 to 399 of 399 from Escherichia coli K-12 : B2550; NAGC-like transcriptional regulator 2662515 yphH 1079034 yphH Shigella flexneri 2a str. 2457T NAGC-like transcriptional regulator NP_838108.1 2661322 D 198215 CDS NP_838109.1 30063938 1079037 complement(2662713..2663966) 1 NC_004741.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2663966 glyA 1079037 glyA Shigella flexneri 2a str. 2457T serine hydroxymethyltransferase NP_838109.1 2662713 R 198215 CDS NP_838110.1 30063939 1079038 2664293..2665483 1 NC_004741.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2665483 hmpA 1079038 hmpA Shigella flexneri 2a str. 2457T nitric oxide dioxygenase NP_838110.1 2664293 D 198215 CDS NP_838111.1 30063940 1079039 complement(2665528..2665866) 1 NC_004741.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 2665866 glnB 1079039 glnB Shigella flexneri 2a str. 2457T nitrogen regulatory protein P-II 1 NP_838111.1 2665528 R 198215 CDS NP_838112.1 30063941 1076483 complement(2665927..2667261) 1 NC_004741.1 residues 1 to 444 of 444 are 95.49 pct identical to residues 1 to 444 of 444 from Escherichia coli K-12 : B2554; 2-component transcriptional regulator 2667261 yfhA 1076483 yfhA Shigella flexneri 2a str. 2457T 2-component transcriptional regulator NP_838112.1 2665927 R 198215 CDS NP_838113.1 30063942 1079041 complement(2667251..2667964) 1 NC_004741.1 residues 1 to 237 of 237 are 84.38 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B2555; hypothetical protein 2667964 yfhG 1079041 yfhG Shigella flexneri 2a str. 2457T hypothetical protein NP_838113.1 2667251 R 198215 CDS NP_838114.1 30063943 1079042 complement(2668129..2669619) 1 NC_004741.1 residues 1 to 488 of 488 are 87.90 pct identical to residues 9 to 496 of 496 from Escherichia coli K-12 : B2556; 2-component sensor protein 2669619 yfhK 1079042 yfhK Shigella flexneri 2a str. 2457T 2-component sensor protein NP_838114.1 2668129 R 198215 CDS NP_838115.1 30063944 1079043 complement(2670114..2674001) 1 NC_004741.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 2674001 purL 1079043 purL Shigella flexneri 2a str. 2457T phosphoribosylformylglycinamidine synthase NP_838115.1 2670114 R 198215 CDS NP_838116.1 30063945 1079044 2674398..2675816 1 NC_004741.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 2675816 yfhD 1079044 yfhD Shigella flexneri 2a str. 2457T transglycosylase NP_838116.1 2674398 D 198215 CDS NP_838117.1 30063946 1079045 complement(2675813..2676349) 1 NC_004741.1 residues 1 to 178 of 178 are 100.00 pct identical to residues 1 to 178 of 178 from Escherichia coli K-12 : B2559; tRNA-specific adenosine deaminase 2676349 yfhC 1079045 yfhC Shigella flexneri 2a str. 2457T tRNA-specific adenosine deaminase NP_838117.1 2675813 R 198215 CDS NP_838118.2 161486454 1079046 complement(2676374..2677009) 1 NC_004741.1 residues 1 to 190 of 190 are 89.47 pct identical to residues 1 to 190 of 190 from Escherichia coli K-12 : B2560; hypothetical protein 2677009 yfhB 1079046 yfhB Shigella flexneri 2a str. 2457T hypothetical protein NP_838118.2 2676374 R 198215 CDS NP_838119.2 161486453 1079048 2677218..2678066 1 NC_004741.1 residues 1 to 306 of 306 are 95.75 pct identical to residues 1 to 306 of 306 from Escherichia coli K-12 : B2561; DNA-binding transcriptional regulator 2678066 yfhH 1079048 yfhH Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator NP_838119.2 2677218 D 198215 CDS NP_838120.1 30063949 1079050 complement(2678519..2678959) 1 NC_004741.1 residues 1 to 146 of 146 are 89.72 pct identical to residues 1 to 146 of 184 from GenPept : >gb|AAC74242.1| (AE000214) inversion of adjacent DNA; at locus of e14 element [Escherichia coli K12]; DNA-invertase 2678959 1079050 S2781 Shigella flexneri 2a str. 2457T DNA-invertase NP_838120.1 2678519 R 198215 CDS NP_838121.1 30063950 1079051 2679457..2681283 1 NC_004741.1 residues 1 to 608 of 608 are 63.54 pct identical to residues 1 to 565 of 565 from NRprotein_Feb03 : >ref|NP_085238.1| invasion plasmid antigen [Shigella flexneri] emb|CAC05787.1| IpaH7.8, member of the IpaH family, secreted by the Mxi-Spa secretion machinery, function unknown [Shigella flexneri]; invasion plasmid antigen 2681283 ipaH_7 1079051 ipaH_7 Shigella flexneri 2a str. 2457T invasion plasmid antigen NP_838121.1 2679457 D 198215 CDS NP_838122.1 30063951 1079052 complement(2681284..2681829) 1 NC_004741.1 residues 5 to 146 of 181 are 60.56 pct identical to residues 24 to 165 of 188 from GenPept : >emb|CAC83575.1| (AJ298298) hypothetical protein [Bacteriophage P27]; hypothetical protein 2681829 1079052 S2783 Shigella flexneri 2a str. 2457T hypothetical protein NP_838122.1 2681284 R 198215 CDS NP_838123.1 30063952 1079053 complement(2681874..2683163) 1 NC_004741.1 residues 1 to 420 of 429 are 36.74 pct identical to residues 1 to 488 of 490 from GenPept : >emb|CAC83574.1| (AJ298298) tail fiber protein [Bacteriophage P27]; tail fiber protein 2683163 1079053 S2784 Shigella flexneri 2a str. 2457T tail fiber protein NP_838123.1 2681874 R 198215 CDS NP_838124.1 30063953 1079054 complement(2683187..2683675) 1 NC_004741.1 residues 9 to 162 of 162 are 75.97 pct identical to residues 29 to 182 of 182 from GenPept : >emb|CAC83573.1| (AJ298298) tail fiber assembly protein [Bacteriophage P27]; tail fiber assembly protein 2683675 1079054 S2785 Shigella flexneri 2a str. 2457T tail fiber assembly protein NP_838124.1 2683187 R 198215 CDS NP_838125.1 30063954 1079056 complement(2683735..2683845) 1 NC_004741.1 residues 3 to 36 of 36 are 76.47 pct identical to residues 525 to 558 of 558 from GenPept : >dbj|BAA00552.1| (D00660) Bcv gene product [Shigella boydii]; tail fiber protein 2683845 1079056 S2786 Shigella flexneri 2a str. 2457T tail fiber protein NP_838125.1 2683735 R 198215 CDS NP_838126.2 161486452 1079057 2684317..2684682 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2684682 1079057 S2787 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_838126.2 2684317 D 198215 CDS NP_838127.2 161486451 1079938 2684640..2685545 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2685545 1079938 S2788 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_838127.2 2684640 D 198215 CDS NP_838128.1 30063957 1079058 complement(2685470..2686456) 1 NC_004741.1 residues 145 to 301 of 328 are 80.89 pct identical to residues 86 to 242 of 332 from GenPept : >emb|CAC83572.1| (AJ298298) tail fiber protein [Bacteriophage P27]; tail fiber protein 2686456 1079058 S2789 Shigella flexneri 2a str. 2457T tail fiber protein NP_838128.1 2685470 R 198215 CDS NP_838129.1 30063958 1079059 complement(2686443..2687048) 1 NC_004741.1 no significant similarities; hypothetical protein 2687048 1079059 S2790 Shigella flexneri 2a str. 2457T hypothetical protein NP_838129.1 2686443 R 198215 CDS NP_838130.1 30063959 1079060 complement(2687050..2687517) 1 NC_004741.1 no significant similarities; bacteriophage protein 2687517 1079060 S2791 Shigella flexneri 2a str. 2457T bacteriophage protein NP_838130.1 2687050 R 198215 CDS NP_838131.1 30063960 1079061 2687812..2688114 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 2688114 1079061 S2793 Shigella flexneri 2a str. 2457T IS600 orfA NP_838131.1 2687812 D 198215 CDS NP_838132.1 30063961 1079062 2688255..2688968 1 NC_004741.1 residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 2688968 1079062 S2794 Shigella flexneri 2a str. 2457T IS600 orfB NP_838132.1 2688255 D 198215 CDS NP_838133.1 30063962 1079063 complement(2689009..2689665) 1 NC_004741.1 no significant similarities; hypothetical protein 2689665 1079063 S2795 Shigella flexneri 2a str. 2457T hypothetical protein NP_838133.1 2689009 R 198215 CDS NP_838134.1 30063963 1079064 complement(2689707..2690108) 1 NC_004741.1 no significant similarities; hypothetical protein 2690108 1079064 S2796 Shigella flexneri 2a str. 2457T hypothetical protein NP_838134.1 2689707 R 198215 CDS NP_838135.1 30063964 1079937 2690323..2690583 1 NC_004741.1 residues 1 to 86 of 86 are 97.67 pct identical to residues 1 to 86 of 86 from Escherichia coli K-12 : B2562; hypothetical protein 2690583 yfhL 1079937 yfhL Shigella flexneri 2a str. 2457T hypothetical protein NP_838135.1 2690323 D 198215 CDS NP_838136.1 30063965 1079065 complement(2691277..2691657) 1 NC_004741.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2691657 acpS 1079065 acpS Shigella flexneri 2a str. 2457T 4'-phosphopantetheinyl transferase NP_838136.1 2691277 R 198215 CDS NP_838137.1 30063966 1079066 complement(2691657..2692388) 1 NC_004741.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 2692388 pdxJ 1079066 pdxJ Shigella flexneri 2a str. 2457T pyridoxine 5'-phosphate synthase NP_838137.1 2691657 R 198215 CDS NP_838138.1 30063967 1079067 complement(2692400..2693128) 1 NC_004741.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2693128 recO 1079067 recO Shigella flexneri 2a str. 2457T DNA repair protein RecO NP_838138.1 2692400 R 198215 CDS NP_838139.1 30063968 1079068 complement(2693140..2694045) 1 NC_004741.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2694045 era 1079068 era Shigella flexneri 2a str. 2457T GTP-binding protein Era NP_838139.1 2693140 R 198215 CDS NP_838140.1 30063969 1080503 complement(2694042..2694722) 1 NC_004741.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2694722 rnc 1080503 rnc Shigella flexneri 2a str. 2457T ribonuclease III NP_838140.1 2694042 R 198215 CDS NP_838141.1 30063970 1079069 complement(2694994..2695968) 1 NC_004741.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 2695968 lepB 1079069 lepB Shigella flexneri 2a str. 2457T signal peptidase I NP_838141.1 2694994 R 198215 CDS NP_838142.1 30063971 1079070 complement(2695984..2697783) 1 NC_004741.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2697783 lepA 1079070 lepA Shigella flexneri 2a str. 2457T GTP-binding protein LepA NP_838142.1 2695984 R 198215 CDS NP_838143.1 30063972 1079071 complement(2697981..2698460) 1 NC_004741.1 involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 2698460 rseC 1079071 rseC Shigella flexneri 2a str. 2457T SoxR reducing system protein RseC NP_838143.1 2697981 R 198215 CDS NP_838144.1 30063973 1079072 complement(2698457..2699413) 1 NC_004741.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 2699413 rseB 1079072 rseB Shigella flexneri 2a str. 2457T periplasmic negative regulator of sigmaE NP_838144.1 2698457 R 198215 CDS NP_838145.1 30063974 1078127 complement(2699413..2700063) 1 NC_004741.1 residues 1 to 216 of 216 are 87.50 pct identical to residues 1 to 216 of 216 from Escherichia coli K-12 : B2572; anti-RNA polymerase sigma factor SigE 2700063 rseA 1078127 rseA Shigella flexneri 2a str. 2457T anti-RNA polymerase sigma factor SigE NP_838145.1 2699413 R 198215 CDS NP_838146.1 30063975 1079073 complement(2700096..2700671) 1 NC_004741.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 2700671 rpoE 1079073 rpoE Shigella flexneri 2a str. 2457T RNA polymerase sigma factor RpoE NP_838146.1 2700096 R 198215 CDS NP_838147.1 30063976 1079075 complement(2702686..2703543) 1 NC_004741.1 residues 1 to 285 of 285 are 89.82 pct identical to residues 1 to 285 of 285 from Escherichia coli K-12 : B2575; enzyme 2703543 yfiC 1079075 yfiC Shigella flexneri 2a str. 2457T enzyme NP_838147.1 2702686 R 198215 CDS NP_838148.1 30063977 1079076 2703555..2704889 1 NC_004741.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2704889 srmB 1079076 srmB Shigella flexneri 2a str. 2457T ATP-dependent RNA helicase SrmB NP_838148.1 2703555 D 198215 CDS NP_838149.1 30063978 1079077 complement(2704924..2705850) 1 NC_004741.1 residues 1 to 306 of 308 are 97.05 pct identical to residues 1 to 306 of 308 from Escherichia coli K-12 : B2577; LYSR-type transcriptional regulator 2705850 yfiE 1079077 yfiE Shigella flexneri 2a str. 2457T LYSR-type transcriptional regulator NP_838149.1 2704924 R 198215 CDS NP_838150.1 30063979 1078810 2705908..2706495 1 NC_004741.1 residues 1 to 195 of 195 are 99.48 pct identical to residues 1 to 195 of 195 from Escherichia coli K-12 : B2578; neutral amino-acid efflux protein 2706495 yfiK 1078810 yfiK Shigella flexneri 2a str. 2457T neutral amino-acid efflux protein NP_838150.1 2705908 D 198215 CDS NP_838151.1 30063980 1079078 complement(2706551..2706934) 1 NC_004741.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 2706934 yfiD 1079078 yfiD Shigella flexneri 2a str. 2457T autonomous glycyl radical cofactor GrcA NP_838151.1 2706551 R 198215 CDS NP_838152.1 30063981 1079079 2707239..2707928 1 NC_004741.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2707928 ung 1079079 ung Shigella flexneri 2a str. 2457T uracil-DNA glycosylase NP_838152.1 2707239 D 198215 CDS NP_838153.1 30063982 1079080 complement(2707976..2709013) 1 NC_004741.1 residues 1 to 345 of 345 are 92.75 pct identical to residues 1 to 345 of 345 from Escherichia coli K-12 : B2581; methyltransferase 2709013 yfiF 1079080 yfiF Shigella flexneri 2a str. 2457T methyltransferase NP_838153.1 2707976 R 198215 CDS NP_838154.1 30063983 1079081 2709220..2709639 1 NC_004741.1 residues 1 to 139 of 139 are 93.52 pct identical to residues 1 to 139 of 139 from Escherichia coli K-12 : B2582; thioredoxin 2 2709639 trxC 1079081 trxC Shigella flexneri 2a str. 2457T thioredoxin 2 NP_838154.1 2709220 D 198215 CDS NP_838155.1 30063984 1079082 2709684..2710406 1 NC_004741.1 residues 1 to 240 of 240 are 99.16 pct identical to residues 1 to 240 of 240 from Escherichia coli K-12 : B2583; hypothetical protein 2710406 yfiP 1079082 yfiP Shigella flexneri 2a str. 2457T hypothetical protein NP_838155.1 2709684 D 198215 CDS NP_838156.1 30063985 1079083 2710438..2713098 1 NC_004741.1 residues 1 to 886 of 886 are 95.59 pct identical to residues 1 to 886 of 886 from Escherichia coli K-12 : B2584; hypothetical protein 2713098 yfiQ 1079083 yfiQ Shigella flexneri 2a str. 2457T hypothetical protein NP_838156.1 2710438 D 198215 CDS NP_838157.1 30063986 1079084 2713212..2714567 1 NC_004741.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2714567 pssA 1079084 pssA Shigella flexneri 2a str. 2457T phosphatidylserine synthase NP_838157.1 2713212 D 198215 CDS NP_838158.1 30063987 1079085 2714664..2714936 1 NC_004741.1 residues 1 to 90 of 90 are 97.77 pct identical to residues 1 to 90 of 90 from Escherichia coli K-12 : B2586; hypothetical protein 2714936 yfiM 1079085 yfiM Shigella flexneri 2a str. 2457T hypothetical protein NP_838158.1 2714664 D 198215 CDS NP_838159.1 30063988 1079086 complement(2714933..2716231) 1 NC_004741.1 residues 1 to 432 of 432 are 92.36 pct identical to residues 1 to 432 of 432 from Escherichia coli K-12 : B2587; alpha-ketoglutarate transporter 2716231 kgtP 1079086 kgtP Shigella flexneri 2a str. 2457T alpha-ketoglutarate transporter NP_838159.1 2714933 R 198215 CDS NP_838160.1 30063989 1079091 2722081..2723409 1 NC_004741.1 residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 2723409 1079091 S2827 Shigella flexneri 2a str. 2457T IS4 orf NP_838160.1 2722081 D 198215 CDS NP_838161.1 30063990 1079092 complement(2723460..2724197) 1 NC_004741.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2724197 1079092 S2828 Shigella flexneri 2a str. 2457T outer membrane protein assembly complex subunit YfiO NP_838161.1 2723460 R 198215 CDS NP_838162.1 30063991 1079093 2724332..2725312 1 NC_004741.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 2725312 rluD 1079093 rluD Shigella flexneri 2a str. 2457T 23S rRNA pseudouridine synthase D NP_838162.1 2724332 D 198215 CDS NP_838163.1 30063992 1079094 2725309..2726040 1 NC_004741.1 residues 1 to 243 of 243 are 98.35 pct identical to residues 1 to 243 of 243 from Escherichia coli K-12 : B2593; hypothetical protein 2726040 yfiH 1079094 yfiH Shigella flexneri 2a str. 2457T hypothetical protein NP_838163.1 2725309 D 198215 CDS NP_838164.1 30063993 1079095 2726170..2728743 1 NC_004741.1 residues 1 to 857 of 857 are 95.44 pct identical to residues 1 to 857 of 857 from Escherichia coli K-12 : B2592; protein disaggregation chaperone 2728743 clpB 1079095 clpB Shigella flexneri 2a str. 2457T protein disaggregation chaperone NP_838164.1 2726170 D 198215 CDS NP_838165.1 30063994 1079096 complement(2728780..2729790) 1 NC_004741.1 residues 1 to 336 of 336 are 99.40 pct identical to residues 113 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; partial; IS4 orf 2729790 1079096 S2832 Shigella flexneri 2a str. 2457T IS4 orf NP_838165.1 2728780 R 198215 CDS NP_838166.1 30063995 1079097 complement(2729727..2730107) 1 NC_004741.1 residues 1 to 126 of 126 are 100.00 pct identical to residues 7 to 132 of 132 from GenPept : >gb|AAL72522.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; partial; IS4 orf 2730107 1079097 S2833 Shigella flexneri 2a str. 2457T IS4 orf NP_838166.1 2729727 R 198215 CDS NP_838167.1 30063996 1079098 2730198..2730404 1 NC_004741.1 residues 1 to 68 of 68 are 94.11 pct identical to residues 1 to 68 of 68 from Escherichia coli K-12 : B2596; hypothetical protein 2730404 1079098 S2834 Shigella flexneri 2a str. 2457T hypothetical protein NP_838167.1 2730198 D 198215 CDS NP_838168.1 30063997 1079099 2730439..2730780 1 NC_004741.1 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2730780 yfiA 1079099 yfiA Shigella flexneri 2a str. 2457T translation inhibitor protein RaiA NP_838168.1 2730439 D 198215 CDS NP_838170.1 30063999 1079101 2731030..2732190 1 NC_004741.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2732190 pheA 1079101 pheA Shigella flexneri 2a str. 2457T bifunctional chorismate mutase/prephenate dehydratase NP_838170.1 2731030 D 198215 CDS NP_838171.1 30064000 1079102 complement(2732233..2733354) 1 NC_004741.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 2733354 tyrA 1079102 tyrA Shigella flexneri 2a str. 2457T bifunctional chorismate mutase/prephenate dehydrogenase NP_838171.1 2732233 R 198215 CDS NP_838172.1 30064001 1079103 complement(2733365..2734435) 1 NC_004741.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 2734435 aroF 1079103 aroF Shigella flexneri 2a str. 2457T phospho-2-dehydro-3-deoxyheptonate aldolase NP_838172.1 2733365 R 198215 CDS NP_838173.1 30064002 1079104 2734645..2735010 1 NC_004741.1 residues 1 to 121 of 121 are 99.17 pct identical to residues 14 to 134 of 134 from Escherichia coli K-12 : B2602; hypothetical protein 2735010 yfiL 1079104 yfiL Shigella flexneri 2a str. 2457T hypothetical protein NP_838173.1 2734645 D 198215 CDS NP_838174.1 30064003 1079105 2735160..2735678 1 NC_004741.1 residues 1 to 172 of 172 are 94.18 pct identical to residues 1 to 172 of 172 from Escherichia coli K-12 : B2603; hypothetical protein 2735678 1079105 S2840 Shigella flexneri 2a str. 2457T hypothetical protein NP_838174.1 2735160 D 198215 CDS NP_838175.1 30064004 1079107 2736909..2737391 1 NC_004741.1 residues 1 to 160 of 160 are 98.75 pct identical to residues 1 to 160 of 160 from Escherichia coli K-12 : B2605; outer membrane lipoprotein 2737391 yfiB 1079107 yfiB Shigella flexneri 2a str. 2457T outer membrane lipoprotein NP_838175.1 2736909 D 198215 CDS NP_838176.1 30064005 1079108 complement(2737468..2737815) 1 NC_004741.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2737815 rplS 1079108 rplS Shigella flexneri 2a str. 2457T 50S ribosomal protein L19 NP_838176.1 2737468 R 198215 CDS NP_838177.1 30064006 1079109 complement(2737857..2738624) 1 NC_004741.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2738624 trmD 1079109 trmD Shigella flexneri 2a str. 2457T tRNA (guanine-N(1)-)-methyltransferase NP_838177.1 2737857 R 198215 CDS NP_838178.1 30064007 1079110 complement(2738655..2739203) 1 NC_004741.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2739203 rimM 1079110 rimM Shigella flexneri 2a str. 2457T 16S rRNA-processing protein RimM NP_838178.1 2738655 R 198215 CDS NP_838179.1 30064008 1079111 complement(2739222..2739470) 1 NC_004741.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2739470 rpsP 1079111 rpsP Shigella flexneri 2a str. 2457T 30S ribosomal protein S16 NP_838179.1 2739222 R 198215 CDS NP_838180.1 30064009 1079112 complement(2739607..2740968) 1 NC_004741.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 2740968 ffh 1079112 ffh Shigella flexneri 2a str. 2457T signal recognition particle protein NP_838180.1 2739607 R 198215 CDS NP_838181.1 30064010 1079113 2741060..2741926 1 NC_004741.1 residues 1 to 288 of 288 are 79.16 pct identical to residues 1 to 288 of 288 from Escherichia coli K-12 : B2611; hypothetical protein 2741926 1079113 S2848 Shigella flexneri 2a str. 2457T hypothetical protein NP_838181.1 2741060 D 198215 CDS NP_838182.1 30064011 1079115 2742550..2743233 1 NC_004741.1 residues 1 to 227 of 227 are 99.55 pct identical to residues 1 to 227 of 227 from Escherichia coli K-12 : B2613; transporter 2743233 yfjD 1079115 yfjD Shigella flexneri 2a str. 2457T transporter NP_838182.1 2742550 D 198215 CDS NP_838183.1 30064012 1079116 complement(2743288..2743881) 1 NC_004741.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2743881 grpE 1079116 grpE Shigella flexneri 2a str. 2457T heat shock protein GrpE NP_838183.1 2743288 R 198215 CDS NP_838184.1 30064013 1079117 2744004..2744882 1 NC_004741.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2744882 ppnK 1079117 ppnK Shigella flexneri 2a str. 2457T inorganic polyphosphate/ATP-NAD kinase NP_838184.1 2744004 D 198215 CDS NP_838185.1 30064014 1079118 2744968..2746629 1 NC_004741.1 residues 1 to 553 of 553 are 95.47 pct identical to residues 1 to 553 of 553 from Escherichia coli K-12 : B2616; recombination and repair protein 2746629 recN 1079118 recN Shigella flexneri 2a str. 2457T recombination and repair protein NP_838185.1 2744968 D 198215 CDS NP_838186.1 30064015 1079119 2746967..2747119 1 NC_004741.1 residues 1 to 50 of 50 are 100.00 pct identical to residues 1 to 50 of 50 from Escherichia coli K-12 : B2617; small membrane protein A 2747119 smpA 1079119 smpA Shigella flexneri 2a str. 2457T small membrane protein A NP_838186.1 2746967 D 198215 CDS NP_838187.1 30064016 1079120 complement(2747181..2747471) 1 NC_004741.1 residues 3 to 96 of 96 are 100.00 pct identical to residues 9 to 102 of 102 from Escherichia coli K-12 : B2618; hypothetical protein 2747471 1079120 S2855 Shigella flexneri 2a str. 2457T hypothetical protein NP_838187.1 2747181 R 198215 CDS NP_838188.1 30064017 1079121 complement(2747461..2747898) 1 NC_004741.1 residues 1 to 145 of 145 are 100.00 pct identical to residues 14 to 158 of 158 from Escherichia coli K-12 : B2619; hypothetical protein 2747898 1079121 S2856 Shigella flexneri 2a str. 2457T hypothetical protein NP_838188.1 2747461 R 198215 CDS NP_838189.1 30064018 1079122 2748069..2748551 1 NC_004741.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2748551 smpB 1079122 smpB Shigella flexneri 2a str. 2457T SsrA-binding protein NP_838189.1 2748069 D 198215 CDS NP_838190.1 30064019 1079124 2749333..2750574 1 NC_004741.1 CP4-57 prophage; integrase; integrase 2750574 1079124 S2859 Shigella flexneri 2a str. 2457T integrase NP_838190.1 2749333 D 198215 CDS NP_838191.1 30064020 1079125 2750774..2751073 1 NC_004741.1 residues 1 to 90 of 99 are 98.88 pct identical to residues 1 to 90 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2751073 1079125 S2860 Shigella flexneri 2a str. 2457T IS1 orfA NP_838191.1 2750774 D 198215 CDS NP_838192.1 30064021 1079126 2751589..2751888 1 NC_004741.1 residues 1 to 99 of 99 are 100.00 pct identical to residues 1 to 99 of 99 from GenPept : >gb|AAL57580.1|AF453442_9 (AF453442) transposase 2 [Escherichia coli]; IS3 orfA 2751888 1079126 S2861 Shigella flexneri 2a str. 2457T IS3 orfA NP_838192.1 2751589 D 198215 CDS NP_838193.1 30064022 1079127 2751885..2752313 1 NC_004741.1 residues 1 to 133 of 142 are 94.73 pct identical to residues 1 to 133 of 288 from GenPept : >gb|AAL57581.1|AF453442_10 (AF453442) transposase 1 [Escherichia coli]; partial; IS3 orfB 2752313 1079127 S2862 Shigella flexneri 2a str. 2457T IS3 orfB NP_838193.1 2751885 D 198215 CDS NP_838194.1 30064023 1079128 2752333..2752440 1 NC_004741.1 residues 1 to 22 of 36 are 100 pct identical to residues 167 to 188 of 305 from GenPept : >gb|CAB37974.1|X02311 (AF453442) hypothetical protein of IS3 [Escherichia coli]; partial; IS3 orfB 2752440 1079128 S2863 Shigella flexneri 2a str. 2457T IS3 orfB NP_838194.1 2752333 D 198215 CDS NP_838196.1 30064025 1079135 2755617..2755889 1 NC_004741.1 residues 1 to 90 of 90 are 96.66 pct identical to residues 1 to 90 of 90 from Escherichia coli K-12 : B2658; hypothetical protein 2755889 1079135 S2870 Shigella flexneri 2a str. 2457T hypothetical protein NP_838196.1 2755617 D 198215 CDS NP_838197.2 161486450 1079136 2756225..2757157 1 NC_004741.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2757157 1079136 S2871 Shigella flexneri 2a str. 2457T hypothetical protein NP_838197.2 2756225 D 198215 CDS NP_838198.1 30064027 1079137 2757111..2758445 1 NC_004741.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 2758445 ygaF 1079137 ygaF Shigella flexneri 2a str. 2457T hydroxyglutarate oxidase NP_838198.1 2757111 D 198215 CDS NP_838199.1 30064028 1079139 2760083..2761210 1 NC_004741.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2761210 gabT 1079139 gabT Shigella flexneri 2a str. 2457T 4-aminobutyrate aminotransferase NP_838199.1 2760083 D 198215 CDS NP_838200.1 30064029 1079140 2761448..2762848 1 NC_004741.1 residues 1 to 466 of 466 are 99.35 pct identical to residues 1 to 466 of 466 from Escherichia coli K-12 : B2663; gamma-aminobutyrate transporter 2762848 gabP 1079140 gabP Shigella flexneri 2a str. 2457T gamma-aminobutyrate transporter NP_838200.1 2761448 D 198215 CDS NP_838201.1 30064030 1079141 2762869..2763531 1 NC_004741.1 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2763531 ygaE 1079141 ygaE Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator CsiR NP_838201.1 2762869 D 198215 CDS NP_838202.1 30064031 1079142 complement(2763532..2763981) 1 NC_004741.1 residues 1 to 149 of 149 are 99.32 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B2665; LysM domain/BON superfamily protein 2763981 ygaU 1079142 ygaU Shigella flexneri 2a str. 2457T LysM domain/BON superfamily protein NP_838202.1 2763532 R 198215 CDS NP_838203.1 30064032 1079143 complement(2764065..2764223) 1 NC_004741.1 residues 1 to 52 of 52 are 98.07 pct identical to residues 1 to 52 of 52 from Escherichia coli K-12 : B2666; hypothetical protein 2764223 1079143 S2878 Shigella flexneri 2a str. 2457T hypothetical protein NP_838203.1 2764065 R 198215 CDS NP_838204.2 161486449 1079144 complement(2764324..2765229) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2765229 1079144 S2879 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_838204.2 2764324 R 198215 CDS NP_838205.2 161486448 1079145 complement(2765187..2765552) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2765552 1079145 S2880 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_838205.2 2765187 R 198215 CDS NP_838206.1 30064035 1079146 2765742..2766041 1 NC_004741.1 residues 1 to 99 of 99 are 97.97 pct identical to residues 1 to 99 of 99 from Escherichia coli K-12 : B2667; hypothetical protein 2766041 1079146 S2881 Shigella flexneri 2a str. 2457T hypothetical protein NP_838206.1 2765742 D 198215 CDS NP_838207.1 30064036 1079147 2766051..2766575 1 NC_004741.1 residues 1 to 174 of 174 are 97.70 pct identical to residues 1 to 174 of 174 from Escherichia coli K-12 : B2668; hypothetical protein 2766575 ygaP 1079147 ygaP Shigella flexneri 2a str. 2457T hypothetical protein NP_838207.1 2766051 D 198215 CDS NP_838208.1 30064037 1079148 complement(2766622..2767026) 1 NC_004741.1 residues 1 to 134 of 134 are 86.56 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B2669; DNA binding protein, nucleoid-associated 2767026 stpA 1079148 stpA Shigella flexneri 2a str. 2457T DNA binding protein, nucleoid-associated NP_838208.1 2766622 R 198215 CDS NP_838209.1 30064038 1079149 2767694..2768143 1 NC_004741.1 residues 1 to 149 of 149 are 100.00 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B2670; hypothetical protein 2768143 1079149 S2884 Shigella flexneri 2a str. 2457T hypothetical protein NP_838209.1 2767694 D 198215 CDS NP_838210.1 30064039 1079150 complement(2768180..2768524) 1 NC_004741.1 residues 1 to 114 of 114 are 100.00 pct identical to residues 1 to 114 of 114 from Escherichia coli K-12 : B2671; hypothetical protein 2768524 ygaC 1079150 ygaC Shigella flexneri 2a str. 2457T hypothetical protein NP_838210.1 2768180 R 198215 CDS NP_838211.1 30064040 1079152 2769253..2769498 1 NC_004741.1 residues 1 to 81 of 81 are 100.00 pct identical to residues 1 to 81 of 81 from Escherichia coli K-12 : B2673; hydrogen donor; glutaredoxin-like protein 2769498 nrdH 1079152 nrdH Shigella flexneri 2a str. 2457T glutaredoxin-like protein NP_838211.1 2769253 D 198215 CDS NP_838212.1 30064041 1079153 2769495..2769905 1 NC_004741.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2769905 nrdI 1079153 nrdI Shigella flexneri 2a str. 2457T ribonucleotide reductase stimulatory protein NP_838212.1 2769495 D 198215 CDS NP_838213.1 30064042 1079154 2769917..2772022 1 NC_004741.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2772022 nrdE 1079154 nrdE Shigella flexneri 2a str. 2457T ribonucleotide-diphosphate reductase subunit alpha NP_838213.1 2769917 D 198215 CDS NP_838214.1 30064043 1079155 2772032..2772991 1 NC_004741.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2772991 nrdF 1079155 nrdF Shigella flexneri 2a str. 2457T ribonucleotide-diphosphate reductase subunit beta NP_838214.1 2772032 D 198215 CDS NP_838215.1 30064044 1079156 2773346..2774548 1 NC_004741.1 with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 2774548 proV 1079156 proV Shigella flexneri 2a str. 2457T glycine betaine transporter ATP-binding subunit NP_838215.1 2773346 D 198215 CDS NP_838216.1 30064045 1079157 2774541..2775605 1 NC_004741.1 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2775605 proW 1079157 proW Shigella flexneri 2a str. 2457T glycine betaine transporter membrane protein NP_838216.1 2774541 D 198215 CDS NP_838217.1 30064046 1079158 2775663..2776655 1 NC_004741.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 2776655 proX 1079158 proX Shigella flexneri 2a str. 2457T glycine betaine transporter periplasmic subunit NP_838217.1 2775663 D 198215 CDS NP_838218.1 30064047 1079160 2776847..2777806 1 NC_004741.1 residues 1 to 87 of 310 are 100.00 pct identical to residues 1 to 87 of 88 from Escherichia coli K-12 : B2680; hypothetical protein 2777806 1079160 S2894 Shigella flexneri 2a str. 2457T hypothetical protein NP_838218.1 2776847 D 198215 CDS NP_838219.1 30064048 1079161 2778150..2778887 1 NC_004741.1 residues 1 to 245 of 245 are 93.46 pct identical to residues 1 to 245 of 245 from Escherichia coli K-12 : B2682; hypothetical protein 2778887 1079161 S2896 Shigella flexneri 2a str. 2457T hypothetical protein NP_838219.1 2778150 D 198215 CDS NP_838220.1 30064049 1079162 2778877..2779212 1 NC_004741.1 residues 1 to 111 of 111 are 90.09 pct identical to residues 1 to 111 of 111 from Escherichia coli K-12 : B2683; hypothetical protein 2779212 ygaH 1079162 ygaH Shigella flexneri 2a str. 2457T hypothetical protein NP_838220.1 2778877 D 198215 CDS NP_838221.1 30064050 1079163 2779303..2779833 1 NC_004741.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2779833 emrR 1079163 emrR Shigella flexneri 2a str. 2457T transcriptional repressor MprA NP_838221.1 2779303 D 198215 CDS NP_838222.1 30064051 1079165 2781149..2782687 1 NC_004741.1 residues 1 to 512 of 512 are 91.99 pct identical to residues 1 to 512 of 512 from Escherichia coli K-12 : B2686; multidrug resistant protein emrB 2782687 emrB 1079165 emrB Shigella flexneri 2a str. 2457T multidrug resistant protein emrB NP_838222.1 2781149 D 198215 CDS NP_838223.1 30064052 1079166 complement(2782751..2783266) 1 NC_004741.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 2783266 ygaG 1079166 ygaG Shigella flexneri 2a str. 2457T S-ribosylhomocysteinase NP_838223.1 2782751 R 198215 CDS NP_838224.1 30064053 1079167 complement(2783416..2784972) 1 NC_004741.1 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 2784972 gshA 1079167 gshA Shigella flexneri 2a str. 2457T glutamate--cysteine ligase NP_838224.1 2783416 R 198215 CDS NP_838225.1 30064054 1079168 complement(2785045..2785473) 1 NC_004741.1 residues 22 to 142 of 142 are 100.00 pct identical to residues 22 to 142 of 142 from Escherichia coli K-12 : B2689; hypothetical protein 2785473 1079168 S2903 Shigella flexneri 2a str. 2457T hypothetical protein NP_838225.1 2785045 R 198215 CDS NP_838226.1 30064055 1079169 complement(2785470..2786036) 1 NC_004741.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase 2786036 yqaB 1079169 yqaB Shigella flexneri 2a str. 2457T fructose-1-phosphatase NP_838226.1 2785470 R 198215 CDS NP_838227.1 30064056 1079175 complement(2787095..2787280) 1 NC_004741.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 2787280 csrA 1079175 csrA Shigella flexneri 2a str. 2457T carbon storage regulator NP_838227.1 2787095 R 198215 CDS NP_838228.1 30064057 1079176 complement(2787515..2790145) 1 NC_004741.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 2790145 alaS 1079176 alaS Shigella flexneri 2a str. 2457T alanyl-tRNA synthetase NP_838228.1 2787515 R 198215 CDS NP_838229.1 30064058 1079177 complement(2790273..2790773) 1 NC_004741.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2790773 recX 1079177 recX Shigella flexneri 2a str. 2457T recombination regulator RecX NP_838229.1 2790273 R 198215 CDS NP_838230.1 30064059 1079178 complement(2791016..2792077) 1 NC_004741.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 2792077 recA 1079178 recA Shigella flexneri 2a str. 2457T recombinase A NP_838230.1 2791016 R 198215 CDS NP_838231.1 30064060 1079179 complement(2792157..2792654) 1 NC_004741.1 residues 1 to 165 of 165 are 100.00 pct identical to residues 1 to 165 of 165 from Escherichia coli K-12 : B2700; competence damage-inducible protein A 2792654 ygaD 1079179 ygaD Shigella flexneri 2a str. 2457T competence damage-inducible protein A NP_838231.1 2792157 R 198215 CDS NP_838232.1 30064061 1079180 complement(2792799..2793884) 1 NC_004741.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 2793884 mltB 1079180 mltB Shigella flexneri 2a str. 2457T murein hydrolase B NP_838232.1 2792799 R 198215 CDS NP_838233.1 30064062 1079182 2794700..2795659 1 NC_004741.1 residues 1 to 319 of 319 are 92.47 pct identical to residues 1 to 319 of 319 from Escherichia coli K-12 : B2703; PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components 2795659 srlE 1079182 srlE Shigella flexneri 2a str. 2457T PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components NP_838233.1 2794700 D 198215 CDS NP_838234.1 30064063 1079183 2795670..2796041 1 NC_004741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; glucitol/sorbitol-specific PTS system component IIA 2796041 srlB 1079183 srlB Shigella flexneri 2a str. 2457T glucitol/sorbitol-specific PTS system component IIA NP_838234.1 2795670 D 198215 CDS NP_838235.1 30064064 1079184 2796045..2796824 1 NC_004741.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2796824 srlD 1079184 srlD Shigella flexneri 2a str. 2457T sorbitol-6-phosphate dehydrogenase NP_838235.1 2796045 D 198215 CDS NP_838236.1 30064065 1079185 2796929..2797288 1 NC_004741.1 regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2797288 gutM 1079185 gutM Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator GutM NP_838236.1 2796929 D 198215 CDS NP_838237.1 30064066 1079186 2797355..2798128 1 NC_004741.1 regulates genes involved in glucitol utilization; DNA-bindng transcriptional repressor SrlR 2798128 srlR 1079186 srlR Shigella flexneri 2a str. 2457T DNA-bindng transcriptional repressor SrlR NP_838237.1 2797355 D 198215 CDS NP_838238.2 161486447 1079187 2798121..2799086 1 NC_004741.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 2799086 gutQ 1079187 gutQ Shigella flexneri 2a str. 2457T D-arabinose 5-phosphate isomerase NP_838238.2 2798121 D 198215 CDS NP_838239.2 161486446 1079188 complement(2799083..2800597) 1 NC_004741.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcriptional regulator 2800597 ygaA 1079188 ygaA Shigella flexneri 2a str. 2457T anaerobic nitric oxide reductase transcriptional regulator NP_838239.2 2799083 R 198215 CDS NP_838240.1 30064069 1079189 2800784..2802223 1 NC_004741.1 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 2802223 1079189 S2924 Shigella flexneri 2a str. 2457T anaerobic nitric oxide reductase flavorubredoxin NP_838240.1 2800784 D 198215 CDS NP_838241.1 30064070 1079190 2802220..2803353 1 NC_004741.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 2803353 ygbD 1079190 ygbD Shigella flexneri 2a str. 2457T nitric oxide reductase NP_838241.1 2802220 D 198215 CDS NP_838242.1 30064071 1079191 complement(2803481..2805733) 1 NC_004741.1 residues 1 to 750 of 750 are 89.73 pct identical to residues 1 to 750 of 750 from Escherichia coli K-12 : B2712; transcriptional regulatory protein 2805733 hypF 1079191 hypF Shigella flexneri 2a str. 2457T transcriptional regulatory protein NP_838242.1 2803481 R 198215 CDS NP_838243.1 30064072 1079192 complement(2805886..2806413) 1 NC_004741.1 involved in electron transport from formate to hydrogen; electron transport protein HydN 2806413 hydN 1079192 hydN Shigella flexneri 2a str. 2457T electron transport protein HydN NP_838243.1 2805886 R 198215 CDS NP_838244.1 30064073 1079193 complement(2806562..2807572) 1 NC_004741.1 residues 1 to 336 of 336 are 97.91 pct identical to residues 2 to 337 of 337 from Escherichia coli K-12 : B2714; ascBF operon repressor 2807572 ascG 1079193 ascG Shigella flexneri 2a str. 2457T ascBF operon repressor NP_838244.1 2806562 R 198215 CDS NP_838245.1 30064074 1079194 complement(2807586..2807705) 1 NC_004741.1 residues 1 to 38 of 39 are 62.79 pct identical to residues 1 to 43 of 180 from Escherichia coli K-12 : B2720; iron-sulfur protein of hydrogenase 3 (part of FHL complex) 2807705 hycF 1079194 hycF Shigella flexneri 2a str. 2457T iron-sulfur protein of hydrogenase 3 (part of FHL complex) NP_838245.1 2807586 R 198215 CDS NP_838246.1 30064075 1079195 complement(2807715..2809424) 1 NC_004741.1 residues 1 to 569 of 569 are 96.83 pct identical to residues 1 to 569 of 569 from Escherichia coli K-12 : B2721; large subunit of hydrogenase 3 (part of FHL complex) 2809424 hycE 1079195 hycE Shigella flexneri 2a str. 2457T large subunit of hydrogenase 3 (part of FHL complex) NP_838246.1 2807715 R 198215 CDS NP_838247.1 30064076 1079196 complement(2809442..2810365) 1 NC_004741.1 residues 1 to 291 of 307 are 91.40 pct identical to residues 1 to 291 of 307 from Escherichia coli K-12 : B2722; membrane-spanning protein of hydrogenase 3 (part of FHL complex) 2810365 hycD 1079196 hycD Shigella flexneri 2a str. 2457T membrane-spanning protein of hydrogenase 3 (part of FHL complex) NP_838247.1 2809442 R 198215 CDS NP_838248.1 30064077 1079197 complement(2810368..2812161) 1 NC_004741.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 2812161 hycC 1079197 hycC Shigella flexneri 2a str. 2457T formate hydrogenlyase subunit 3 NP_838248.1 2810368 R 198215 CDS NP_838249.1 30064078 1079198 complement(2812198..2812809) 1 NC_004741.1 residues 1 to 203 of 203 are 91.62 pct identical to residues 1 to 203 of 203 from Escherichia coli K-12 : B2724; small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) 2812809 hycB 1079198 hycB Shigella flexneri 2a str. 2457T small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) NP_838249.1 2812198 R 198215 CDS NP_838250.1 30064079 1079199 complement(2812934..2813395) 1 NC_004741.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 2813395 hycA 1079199 hycA Shigella flexneri 2a str. 2457T formate hydrogenlyase regulatory protein HycA NP_838250.1 2812934 R 198215 CDS NP_838251.1 30064080 1079200 2813595..2813957 1 NC_004741.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 2813957 hypA 1079200 hypA Shigella flexneri 2a str. 2457T hydrogenase nickel incorporation protein NP_838251.1 2813595 D 198215 CDS NP_838252.1 30064081 1079201 2813961..2814833 1 NC_004741.1 GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 2814833 hypB 1079201 hypB Shigella flexneri 2a str. 2457T hydrogenase nickel incorporation protein HypB NP_838252.1 2813961 D 198215 CDS NP_838253.1 30064082 1079202 2814824..2815096 1 NC_004741.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 2815096 hypC 1079202 hypC Shigella flexneri 2a str. 2457T hydrogenase assembly chaperone NP_838253.1 2814824 D 198215 CDS NP_838254.1 30064083 1079203 2815096..2816217 1 NC_004741.1 residues 1 to 373 of 373 are 99.73 pct identical to residues 1 to 373 of 373 from Escherichia coli K-12 : B2729; pleiotrophic effects on 3 hydrogenase isozymes; hydrogenase isoenzyme HypD 2816217 hypD 1079203 hypD Shigella flexneri 2a str. 2457T hydrogenase isoenzyme HypD NP_838254.1 2815096 D 198215 CDS NP_838255.1 30064084 1079204 2816256..2817224 1 NC_004741.1 residues 1 to 322 of 322 are 98.44 pct identical to residues 1 to 322 of 322 from Escherichia coli K-12 : B2730; has structural role in maturation of all 3 hydrogenases; hypE product 2817224 hypE 1079204 hypE Shigella flexneri 2a str. 2457T hypE product NP_838255.1 2816256 D 198215 CDS NP_838256.1 30064085 1079205 2817298..2819376 1 NC_004741.1 residues 1 to 692 of 692 are 96.67 pct identical to residues 1 to 692 of 692 from Escherichia coli K-12 : B2731; formate hydrogen-lyase transcriptional activator for fdhF, hyc and hyp operons 2819376 fhlA 1079205 fhlA Shigella flexneri 2a str. 2457T formate hydrogen-lyase transcriptional activator for fdhF, hyc and hyp operons NP_838256.1 2817298 D 198215 CDS NP_838257.1 30064086 1079206 complement(2819413..2819766) 1 NC_004741.1 residues 1 to 117 of 117 are 99.14 pct identical to residues 1 to 117 of 117 from Escherichia coli K-12 : B2732; hypothetical protein 2819766 ygbA 1079206 ygbA Shigella flexneri 2a str. 2457T hypothetical protein NP_838257.1 2819413 R 198215 CDS NP_838258.1 30064087 1079207 complement(2819829..2820332) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 2820332 1079207 S2942 Shigella flexneri 2a str. 2457T IS1 orfB NP_838258.1 2819829 R 198215 CDS NP_838259.1 30064088 1079208 complement(2820251..2820526) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2820526 1079208 S2943 Shigella flexneri 2a str. 2457T IS1 orfA NP_838259.1 2820251 R 198215 CDS NP_838260.1 30064089 1079209 2820830..2823391 1 NC_004741.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2823391 mutS 1079209 mutS Shigella flexneri 2a str. 2457T DNA mismatch repair protein MutS NP_838260.1 2820830 D 198215 CDS NP_838261.1 30064090 1079211 complement(2824200..2824997) 1 NC_004741.1 residues 1 to 265 of 265 are 98.11 pct identical to residues 1 to 265 of 265 from Escherichia coli K-12 : B2735; DEOR-type transcriptional regulator 2824997 ygbI 1079211 ygbI Shigella flexneri 2a str. 2457T DEOR-type transcriptional regulator NP_838261.1 2824200 R 198215 CDS NP_838262.1 30064091 1079214 2826353..2826655 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 2826655 1079214 S2949 Shigella flexneri 2a str. 2457T IS600 orfA NP_838262.1 2826353 D 198215 CDS NP_838263.1 30064092 1079215 2826796..2827509 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAB86997.1| (U97492) hypothetical 31 KD protein [Shigella flexneri]; IS600 orfB 2827509 1079215 S2950 Shigella flexneri 2a str. 2457T IS600 orfB NP_838263.1 2826796 D 198215 CDS NP_838264.1 30064093 1079216 complement(2827837..2829933) 1 NC_004741.1 residues 4 to 698 of 698 are 75.10 pct identical to residues 2 to 696 of 696 from GenPept : >dbj|BAB38368.1| (AP002567) phage transposase [Escherichia coli O157:H7]; phage transposase 2829933 1079216 S2951 Shigella flexneri 2a str. 2457T phage transposase NP_838264.1 2827837 R 198215 CDS NP_838265.1 30064094 1079217 complement(2829935..2830186) 1 NC_004741.1 residues 1 to 83 of 83 are 54.21 pct identical to residues 1 to 82 of 82 from GenPept : >dbj|BAB38367.1| (AP002567) DNA-binding protein [Escherichia coli O157:H7]; DNA-binding protein 2830186 1079217 S2952 Shigella flexneri 2a str. 2457T DNA-binding protein NP_838265.1 2829935 R 198215 CDS NP_838266.1 30064095 1079218 2830351..2830914 1 NC_004741.1 residues 11 to 184 of 187 are 42.69 pct identical to residues 2 to 175 of 176 from GenPept : >dbj|BAB38366.1| (AP002567) regulatory protein [Escherichia coli O157:H7]; regulatory protein 2830914 1079218 S2953 Shigella flexneri 2a str. 2457T regulatory protein NP_838266.1 2830351 D 198215 CDS NP_838267.1 30064096 1079219 complement(2831184..2832134) 1 NC_004741.1 residues 1 to 316 of 316 are 97.15 pct identical to residues 1 to 316 of 475 from GenPept : >gb|AAG57845.1|AE005501_14 (AE005501) orf; hypothetical protein [Escherichia coli O157:H7 EDL933]; 4-hydroxybenzoate decarboxylase 2832134 yclC 1079219 yclC Shigella flexneri 2a str. 2457T 4-hydroxybenzoate decarboxylase NP_838267.1 2831184 R 198215 CDS NP_838268.1 30064097 1079220 complement(2832134..2832727) 1 NC_004741.1 residues 1 to 197 of 197 are 100.00 pct identical to residues 1 to 197 of 197 from GenPept : >gb|AAG14986.1|AF242210_5 (AF242210) phenylacrylic acid decarboxylase-like protein [Escherichia coli]; phenylacrylic acid decarboxylase-like protein 2832727 padI 1079220 padI Shigella flexneri 2a str. 2457T phenylacrylic acid decarboxylase-like protein NP_838268.1 2832134 R 198215 CDS NP_838269.1 30064098 1079221 2832874..2833281 1 NC_004741.1 residues 1 to 135 of 135 are 97.03 pct identical to residues 1 to 135 of 135 from GenPept : >gb|AAG14991.1|AF242211_3 (AF242211) transcriptional regulator protein [Escherichia coli]; transcriptional regulator 2833281 1079221 S2956 Shigella flexneri 2a str. 2457T transcriptional regulator NP_838269.1 2832874 D 198215 CDS NP_838270.1 30064099 1079223 complement(2834455..2835594) 1 NC_004741.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD 2835594 nlpD 1079223 nlpD Shigella flexneri 2a str. 2457T lipoprotein NlpD NP_838270.1 2834455 R 198215 CDS NP_838271.1 30064100 1079224 complement(2835734..2836360) 1 NC_004741.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 2836360 pcm 1079224 pcm Shigella flexneri 2a str. 2457T protein-L-isoaspartate O-methyltransferase NP_838271.1 2835734 R 198215 CDS NP_838272.1 30064101 1079225 complement(2836354..2837115) 1 NC_004741.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 2837115 surE 1079225 surE Shigella flexneri 2a str. 2457T stationary phase survival protein SurE NP_838272.1 2836354 R 198215 CDS NP_838273.1 30064102 1079226 complement(2837096..2838145) 1 NC_004741.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 2838145 truD 1079226 truD Shigella flexneri 2a str. 2457T tRNA pseudouridine synthase D NP_838273.1 2837096 R 198215 CDS NP_838274.1 30064103 1079227 complement(2838142..2838621) 1 NC_004741.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 2838621 ispF 1079227 ispF Shigella flexneri 2a str. 2457T 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase NP_838274.1 2838142 R 198215 CDS NP_838275.1 30064104 1079228 complement(2838621..2839331) 1 NC_004741.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2839331 ispD 1079228 ispD Shigella flexneri 2a str. 2457T 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NP_838275.1 2838621 R 198215 CDS NP_838276.1 30064105 1079229 complement(2839350..2839661) 1 NC_004741.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 2839661 ftsB 1079229 ftsB Shigella flexneri 2a str. 2457T cell division protein FtsB NP_838276.1 2839350 R 198215 CDS NP_838277.1 30064106 1079230 complement(2839855..2840178) 1 NC_004741.1 residues 1 to 107 of 107 are 99.06 pct identical to residues 1 to 107 of 107 from Escherichia coli K-12 : B2749; hypothetical protein 2840178 ygbE 1079230 ygbE Shigella flexneri 2a str. 2457T hypothetical protein NP_838277.1 2839855 R 198215 CDS NP_838278.1 30064107 1079231 complement(2840228..2840833) 1 NC_004741.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 2840833 cysC 1079231 cysC Shigella flexneri 2a str. 2457T adenylylsulfate kinase NP_838278.1 2840228 R 198215 CDS NP_838279.1 30064108 1079232 complement(2840833..2842260) 1 NC_004741.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 2842260 cysN 1079232 cysN Shigella flexneri 2a str. 2457T sulfate adenylyltransferase subunit 1 NP_838279.1 2840833 R 198215 CDS NP_838280.1 30064109 1079233 complement(2842262..2843170) 1 NC_004741.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 2843170 cysD 1079233 cysD Shigella flexneri 2a str. 2457T sulfate adenylyltransferase subunit 2 NP_838280.1 2842262 R 198215 CDS NP_838281.1 30064110 1079234 2843422..2844459 1 NC_004741.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase isozyme conversion aminopeptidase 2844459 iap 1079234 iap Shigella flexneri 2a str. 2457T alkaline phosphatase isozyme conversion aminopeptidase NP_838281.1 2843422 D 198215 CDS NP_838282.1 30064111 1079236 complement(2846306..2847040) 1 NC_004741.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 2847040 cysH 1079236 cysH Shigella flexneri 2a str. 2457T phosphoadenosine phosphosulfate reductase NP_838282.1 2846306 R 198215 CDS NP_838283.1 30064112 1079237 complement(2847114..2848826) 1 NC_004741.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 2848826 cysI 1079237 cysI Shigella flexneri 2a str. 2457T sulfite reductase subunit beta NP_838283.1 2847114 R 198215 CDS NP_838284.1 30064113 1079238 complement(2848826..2850625) 1 NC_004741.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 2850625 cysJ 1079238 cysJ Shigella flexneri 2a str. 2457T sulfite reductase subunit alpha NP_838284.1 2848826 R 198215 CDS NP_838285.1 30064114 1079239 2850944..2851306 1 NC_004741.1 residues 1 to 120 of 120 are 100.00 pct identical to residues 2 to 121 of 121 from Escherichia coli K-12 : B2765; 6-pyruvoyl tetrahydrobiopterin synthase 2851306 ygcM 1079239 ygcM Shigella flexneri 2a str. 2457T 6-pyruvoyl tetrahydrobiopterin synthase NP_838285.1 2850944 D 198215 CDS NP_838286.1 30064115 1079240 2851354..2852655 1 NC_004741.1 residues 1 to 433 of 433 are 89.37 pct identical to residues 1 to 433 of 433 from Escherichia coli K-12 : B2766; hypothetical protein 2852655 ygcN 1079240 ygcN Shigella flexneri 2a str. 2457T hypothetical protein NP_838286.1 2851354 D 198215 CDS NP_838287.1 30064116 1079241 2852610..2852906 1 NC_004741.1 residues 1 to 98 of 98 are 92.85 pct identical to residues 1 to 98 of 98 from Escherichia coli K-12 : B2767; hypothetical protein 2852906 ygcO 1079241 ygcO Shigella flexneri 2a str. 2457T hypothetical protein NP_838287.1 2852610 D 198215 CDS NP_838288.1 30064117 1079243 complement(2853646..2854539) 1 NC_004741.1 residues 1 to 297 of 297 are 97.30 pct identical to residues 1 to 297 of 297 from Escherichia coli K-12 : B2769; flavoprotein 2854539 ygcQ 1079243 ygcQ Shigella flexneri 2a str. 2457T flavoprotein NP_838288.1 2853646 R 198215 CDS NP_838289.1 30064118 1079244 complement(2854503..2855282) 1 NC_004741.1 residues 1 to 259 of 259 are 93.05 pct identical to residues 3 to 261 of 261 from Escherichia coli K-12 : B2770; transporter 2855282 ygcR 1079244 ygcR Shigella flexneri 2a str. 2457T transporter NP_838289.1 2854503 R 198215 CDS NP_838290.1 30064119 1079245 complement(2855260..2856669) 1 NC_004741.1 residues 1 to 469 of 469 are 74.84 pct identical to residues 1 to 469 of 469 from Escherichia coli K-12 : B2771; transporter 2856669 ygcS 1079245 ygcS Shigella flexneri 2a str. 2457T transporter NP_838290.1 2855260 R 198215 CDS NP_838291.1 30064120 1079246 complement(2856691..2857485) 1 NC_004741.1 residues 1 to 264 of 264 are 99.24 pct identical to residues 1 to 264 of 264 from Escherichia coli K-12 : B2772; hypothetical protein 2857485 1079246 S2981 Shigella flexneri 2a str. 2457T hypothetical protein NP_838291.1 2856691 R 198215 CDS NP_838292.1 30064121 1079247 2857600..2857875 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2857875 1079247 S2982 Shigella flexneri 2a str. 2457T IS1 orfA NP_838292.1 2857600 D 198215 CDS NP_838293.1 30064122 1079248 2857794..2858297 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2858297 1079248 S2983 Shigella flexneri 2a str. 2457T IS1 orfB NP_838293.1 2857794 D 198215 CDS NP_838294.1 30064123 1079249 complement(2858336..2859007) 1 NC_004741.1 residues 1 to 223 of 223 are 93.27 pct identical to residues 1 to 223 of 223 from Escherichia coli K-12 : B2777; hypothetical protein 2859007 ygcF 1079249 ygcF Shigella flexneri 2a str. 2457T hypothetical protein NP_838294.1 2858336 R 198215 CDS NP_838295.1 30064124 1079250 2859401..2859676 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2859676 1079250 S2985 Shigella flexneri 2a str. 2457T IS1 orfA NP_838295.1 2859401 D 198215 CDS NP_838296.1 30064125 1079251 2859595..2860098 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 2860098 1079251 S2986 Shigella flexneri 2a str. 2457T IS1 orfB NP_838296.1 2859595 D 198215 CDS NP_838297.1 30064126 1079253 complement(2860969..2862267) 1 NC_004741.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 2862267 eno 1079253 eno Shigella flexneri 2a str. 2457T phosphopyruvate hydratase NP_838297.1 2860969 R 198215 CDS NP_838298.1 30064127 1079254 complement(2862355..2863992) 1 NC_004741.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 2863992 pyrG 1079254 pyrG Shigella flexneri 2a str. 2457T CTP synthetase NP_838298.1 2862355 R 198215 CDS NP_838299.1 30064128 1079255 complement(2864220..2865011) 1 NC_004741.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase 2865011 mazG 1079255 mazG Shigella flexneri 2a str. 2457T nucleoside triphosphate pyrophosphohydrolase NP_838299.1 2864220 R 198215 CDS NP_838300.1 30064129 1079256 complement(2865107..2867341) 1 NC_004741.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 2867341 relA 1079256 relA Shigella flexneri 2a str. 2457T GDP/GTP pyrophosphokinase NP_838300.1 2865107 R 198215 CDS NP_838301.1 30064130 1079257 complement(2867389..2868690) 1 NC_004741.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 2868690 rumA 1079257 rumA Shigella flexneri 2a str. 2457T 23S rRNA 5-methyluridine methyltransferase NP_838301.1 2867389 R 198215 CDS NP_838302.1 30064131 1079258 2868747..2871503 1 NC_004741.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 2871503 barA 1079258 barA Shigella flexneri 2a str. 2457T hybrid sensory histidine kinase BarA NP_838302.1 2868747 D 198215 CDS NP_838303.1 30064132 1079259 complement(2871735..2873075) 1 NC_004741.1 residues 1 to 446 of 446 are 99.77 pct identical to residues 1 to 446 of 446 from Escherichia coli K-12 : B2787; glucarate dehydratase 2873075 ygcX 1079259 ygcX Shigella flexneri 2a str. 2457T glucarate dehydratase NP_838303.1 2871735 R 198215 CDS NP_838304.1 30064133 1079260 complement(2873096..2874436) 1 NC_004741.1 residues 1 to 446 of 446 are 94.61 pct identical to residues 1 to 446 of 446 from Escherichia coli K-12 : B2788; glucarate dehydratase 2874436 ygcY 1079260 ygcY Shigella flexneri 2a str. 2457T glucarate dehydratase NP_838304.1 2873096 R 198215 CDS NP_838305.1 30064134 1079262 complement(2874438..2875790) 1 NC_004741.1 residues 1 to 450 of 450 are 99.33 pct identical to residues 1 to 450 of 450 from Escherichia coli K-12 : B2789; transporter 2875790 1079262 S2996 Shigella flexneri 2a str. 2457T transporter NP_838305.1 2874438 R 198215 CDS NP_838306.1 30064135 1079263 complement(2876224..2876673) 1 NC_004741.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 2876673 1079263 S2997 Shigella flexneri 2a str. 2457T flavodoxin NP_838306.1 2876224 R 198215 CDS NP_838307.1 30064136 1079264 complement(2876691..2877473) 1 NC_004741.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 2877473 yqcB 1079264 yqcB Shigella flexneri 2a str. 2457T tRNA pseudouridine synthase C NP_838307.1 2876691 R 198215 CDS NP_838308.1 30064137 1079265 complement(2877473..2877802) 1 NC_004741.1 residues 1 to 109 of 109 are 85.32 pct identical to residues 1 to 109 of 109 from Escherichia coli K-12 : B2792; hypothetical protein 2877802 1079265 S2999 Shigella flexneri 2a str. 2457T hypothetical protein NP_838308.1 2877473 R 198215 CDS NP_838309.1 30064138 1079267 complement(2878424..2878969) 1 NC_004741.1 SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 2878969 syd 1079267 syd Shigella flexneri 2a str. 2457T SecY interacting protein Syd NP_838309.1 2878424 R 198215 CDS NP_838310.1 30064139 1079268 2879037..2879885 1 NC_004741.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 2879885 queF 1079268 queF Shigella flexneri 2a str. 2457T 7-cyano-7-deazaguanine reductase NP_838310.1 2879037 D 198215 CDS NP_838311.1 30064140 1079269 2879997..2881361 1 NC_004741.1 residues 1 to 454 of 454 are 100.00 pct identical to residues 1 to 454 of 454 from Escherichia coli K-12 : B2795; hypothetical protein 2881361 ygdH 1079269 ygdH Shigella flexneri 2a str. 2457T hypothetical protein NP_838311.1 2879997 D 198215 CDS NP_838312.1 30064141 1079270 2881463..2882797 1 NC_004741.1 residues 1 to 437 of 444 are 99.77 pct identical to residues 7 to 443 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 2882797 1079270 S3004 Shigella flexneri 2a str. 2457T IS4 orf NP_838312.1 2881463 D 198215 CDS NP_838313.1 30064142 1079271 2883357..2884646 1 NC_004741.1 residues 1 to 429 of 429 are 96.27 pct identical to residues 1 to 429 of 429 from Escherichia coli K-12 : B2796; serine transporter 2884646 sdaC 1079271 sdaC Shigella flexneri 2a str. 2457T serine transporter NP_838313.1 2883357 D 198215 CDS NP_838314.1 30064143 1079272 2884704..2886071 1 NC_004741.1 residues 1 to 455 of 455 are 90.76 pct identical to residues 1 to 455 of 455 from Escherichia coli K-12 : B2797; L-serine dehydratase (deaminase), L-SD2 2886071 sdaB 1079272 sdaB Shigella flexneri 2a str. 2457T L-serine dehydratase (deaminase), L-SD2 NP_838314.1 2884704 D 198215 CDS NP_838315.1 30064144 1079970 2886092..2886937 1 NC_004741.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 2886937 xni 1079970 xni Shigella flexneri 2a str. 2457T exonuclease IX NP_838315.1 2886092 D 198215 CDS NP_838316.1 30064145 1079273 complement(2886990..2888138) 1 NC_004741.1 residues 1 to 382 of 382 are 99.47 pct identical to residues 2 to 383 of 383 from Escherichia coli K-12 : B2799; L-1,2-propanediol oxidoreductase 2888138 fucO 1079273 fucO Shigella flexneri 2a str. 2457T L-1,2-propanediol oxidoreductase NP_838316.1 2886990 R 198215 CDS NP_838317.1 30064146 1079274 complement(2888166..2888813) 1 NC_004741.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 2888813 fucA 1079274 fucA Shigella flexneri 2a str. 2457T L-fuculose phosphate aldolase NP_838317.1 2888166 R 198215 CDS NP_838318.1 30064147 1079275 2889360..2890676 1 NC_004741.1 residues 1 to 438 of 438 are 89.49 pct identical to residues 1 to 438 of 438 from Escherichia coli K-12 : B2801; L-fucose transporter 2890676 fucP 1079275 fucP Shigella flexneri 2a str. 2457T L-fucose transporter NP_838318.1 2889360 D 198215 CDS NP_838319.1 30064148 1079277 2890709..2892484 1 NC_004741.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2892484 fucI 1079277 fucI Shigella flexneri 2a str. 2457T L-fucose isomerase NP_838319.1 2890709 D 198215 CDS NP_838320.1 30064149 1078544 2894014..2894436 1 NC_004741.1 residues 1 to 140 of 140 are 99.28 pct identical to residues 1 to 140 of 140 from Escherichia coli K-12 : B2804; protein of fucose operon 2894436 fucU 1078544 fucU Shigella flexneri 2a str. 2457T protein of fucose operon NP_838320.1 2894014 D 198215 CDS NP_838321.1 30064150 1079279 2894494..2895225 1 NC_004741.1 regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 2895225 fucR 1079279 fucR Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator FucR NP_838321.1 2894494 D 198215 CDS NP_838322.1 30064151 1079281 complement(2895269..2896369) 1 NC_004741.1 residues 1 to 366 of 366 are 99.72 pct identical to residues 1 to 366 of 366 from Escherichia coli K-12 : B2806; RNA 2'-O-ribose methyltransferase 2896369 ygdE 1079281 ygdE Shigella flexneri 2a str. 2457T RNA 2'-O-ribose methyltransferase NP_838322.1 2895269 R 198215 CDS NP_838323.1 30064152 1079282 complement(2896362..2896757) 1 NC_004741.1 residues 1 to 131 of 131 are 100.00 pct identical to residues 1 to 131 of 131 from Escherichia coli K-12 : B2807; hypothetical protein 2896757 ygdD 1079282 ygdD Shigella flexneri 2a str. 2457T hypothetical protein NP_838323.1 2896362 R 198215 CDS NP_838324.1 30064153 1079283 complement(2896776..2897693) 1 NC_004741.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 2897693 gcvA 1079283 gcvA Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator GcvA NP_838324.1 2896776 R 198215 CDS NP_838325.1 30064154 1079285 complement(2898044..2898274) 1 NC_004741.1 residues 1 to 76 of 76 are 97.36 pct identical to residues 1 to 76 of 76 from Escherichia coli K-12 : B2809; hypothetical protein 2898274 1079285 S3018 Shigella flexneri 2a str. 2457T hypothetical protein NP_838325.1 2898044 R 198215 CDS NP_838326.1 30064155 1079286 2898463..2899668 1 NC_004741.1 residues 1 to 401 of 401 are 98.75 pct identical to residues 1 to 401 of 401 from Escherichia coli K-12 : B2810; cysteine sulfinate desulfinase 2899668 1079286 S3019 Shigella flexneri 2a str. 2457T cysteine sulfinate desulfinase NP_838326.1 2898463 D 198215 CDS NP_838327.1 30064156 1079287 2899668..2900111 1 NC_004741.1 residues 1 to 147 of 147 are 98.63 pct identical to residues 1 to 147 of 147 from Escherichia coli K-12 : B2811; hypothetical protein 2900111 ygdK 1079287 ygdK Shigella flexneri 2a str. 2457T hypothetical protein NP_838327.1 2899668 D 198215 CDS NP_838328.1 30064157 1079289 complement(2900162..2900968) 1 NC_004741.1 residues 1 to 268 of 268 are 99.62 pct identical to residues 1 to 268 of 268 from Escherichia coli K-12 : B2812; enzyme 2900968 ygdL 1079289 ygdL Shigella flexneri 2a str. 2457T enzyme NP_838328.1 2900162 R 198215 CDS NP_838329.1 30064158 1079291 complement(2901206..2902303) 1 NC_004741.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 2902303 mltA 1079291 mltA Shigella flexneri 2a str. 2457T murein transglycosylase A NP_838329.1 2901206 R 198215 CDS NP_838330.1 30064159 1079293 complement(2902773..2904116) 1 NC_004741.1 residues 1 to 447 of 447 are 92.61 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 : B2817; amidase 2904116 1079293 S3025 Shigella flexneri 2a str. 2457T amidase NP_838330.1 2902773 R 198215 CDS NP_838331.1 30064160 1079294 2904258..2905589 1 NC_004741.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 2905589 argA 1079294 argA Shigella flexneri 2a str. 2457T N-acetylglutamate synthase NP_838331.1 2904258 D 198215 CDS NP_838332.1 30064161 1079295 complement(2905651..2907477) 1 NC_004741.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 2907477 recD 1079295 recD Shigella flexneri 2a str. 2457T exonuclease V subunit alpha NP_838332.1 2905651 R 198215 CDS NP_838333.1 30064162 1079296 complement(2907477..2911019) 1 NC_004741.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 2911019 recB 1079296 recB Shigella flexneri 2a str. 2457T exonuclease V subunit beta NP_838333.1 2907477 R 198215 CDS NP_838334.1 30064163 1079298 complement(2911012..2913900) 1 NC_004741.1 residues 1 to 962 of 962 are 99.68 pct identical to residues 1 to 962 of 962 from Escherichia coli K-12 : B2821; protease III 2913900 ptr 1079298 ptr Shigella flexneri 2a str. 2457T protease III NP_838334.1 2911012 R 198215 CDS NP_838335.1 30064164 1079299 complement(2914076..2917444) 1 NC_004741.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 2917444 recC 1079299 recC Shigella flexneri 2a str. 2457T exonuclease V subunit gamma NP_838335.1 2914076 R 198215 CDS NP_838336.1 30064165 1079300 complement(2917457..2917807) 1 NC_004741.1 residues 1 to 116 of 116 are 81.03 pct identical to residues 1 to 107 of 107 from Escherichia coli K-12 : B2823; hypothetical protein 2917807 ppdC 1079300 ppdC Shigella flexneri 2a str. 2457T hypothetical protein NP_838336.1 2917457 R 198215 CDS NP_838337.2 161486445 1079301 complement(2917792..2918199) 1 NC_004741.1 residues 16 to 121 of 121 are 96.22 pct identical to residues 16 to 121 of 121 from Escherichia coli K-12 : B2824; hypothetical protein 2918199 ygdB 1079301 ygdB Shigella flexneri 2a str. 2457T hypothetical protein NP_838337.2 2917792 R 198215 CDS NP_838338.1 30064167 1079303 complement(2918196..2918759) 1 NC_004741.1 residues 1 to 187 of 187 are 98.39 pct identical to residues 1 to 187 of 187 from Escherichia coli K-12 : B2825; hypothetical protein 2918759 ppdB 1079303 ppdB Shigella flexneri 2a str. 2457T hypothetical protein NP_838338.1 2918196 R 198215 CDS NP_838339.1 30064168 1079305 complement(2919404..2920198) 1 NC_004741.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 2920198 thyA 1079305 thyA Shigella flexneri 2a str. 2457T thymidylate synthase NP_838339.1 2919404 R 198215 CDS NP_838340.1 30064169 1079306 complement(2920205..2921080) 1 NC_004741.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 2921080 lgt 1079306 lgt Shigella flexneri 2a str. 2457T prolipoprotein diacylglyceryl transferase NP_838340.1 2920205 R 198215 CDS NP_838341.1 30064170 1079307 complement(2921231..2923477) 1 NC_004741.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain 2923477 ptsP 1079307 ptsP Shigella flexneri 2a str. 2457T fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain NP_838341.1 2921231 R 198215 CDS NP_838342.1 30064171 1079308 complement(2923490..2924020) 1 NC_004741.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 2924020 ygdP 1079308 ygdP Shigella flexneri 2a str. 2457T dinucleoside polyphosphate hydrolase NP_838342.1 2923490 R 198215 CDS NP_838343.1 30064172 1078444 2924705..2925394 1 NC_004741.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 2925394 mutH 1078444 mutH Shigella flexneri 2a str. 2457T DNA mismatch repair protein NP_838343.1 2924705 D 198215 CDS NP_838344.1 30064173 1079309 2925463..2926176 1 NC_004741.1 residues 1 to 237 of 237 are 76.37 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B2832; transporter 2926176 1079309 S3040 Shigella flexneri 2a str. 2457T transporter NP_838344.1 2925463 D 198215 CDS NP_838345.1 30064174 1078237 2926314..2926532 1 NC_004741.1 residues 1 to 72 of 72 are 100.00 pct identical to residues 1 to 72 of 72 from Escherichia coli K-12 : B2833; hypothetical protein 2926532 1078237 S3041 Shigella flexneri 2a str. 2457T hypothetical protein NP_838345.1 2926314 D 198215 CDS NP_838346.1 30064175 1079759 2926640..2927680 1 NC_004741.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo-keto reductase 2927680 tas 1079759 tas Shigella flexneri 2a str. 2457T aldo-keto reductase NP_838346.1 2926640 D 198215 CDS NP_838347.1 30064176 1079310 complement(2927713..2928903) 1 NC_004741.1 residues 1 to 396 of 396 are 84.63 pct identical to residues 1 to 397 of 397 from Escherichia coli K-12 : B2835; lysophospholipid transporter LplT 2928903 ygeD 1079310 ygeD Shigella flexneri 2a str. 2457T lysophospholipid transporter LplT NP_838347.1 2927713 R 198215 CDS NP_838348.1 30064177 1079311 complement(2928896..2931055) 1 NC_004741.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 2931055 aas 1079311 aas Shigella flexneri 2a str. 2457T bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase NP_838348.1 2928896 R 198215 CDS NP_838349.1 30064178 1079312 2931641..2932672 1 NC_004741.1 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 2932672 galR 1079312 galR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator GalR NP_838349.1 2931641 D 198215 CDS NP_838350.1 30064179 1079313 complement(2932679..2933941) 1 NC_004741.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 2933941 lysA 1079313 lysA Shigella flexneri 2a str. 2457T diaminopimelate decarboxylase NP_838350.1 2932679 R 198215 CDS NP_838351.1 30064180 1079314 2934063..2934998 1 NC_004741.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 2934998 lysR 1079314 lysR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator LysR NP_838351.1 2934063 D 198215 CDS NP_838352.1 30064181 1079315 complement(2934985..2935677) 1 NC_004741.1 residues 1 to 230 of 230 are 99.13 pct identical to residues 1 to 230 of 230 from Escherichia coli K-12 : B2840; racemase 2935677 ygeA 1079315 ygeA Shigella flexneri 2a str. 2457T racemase NP_838352.1 2934985 R 198215 CDS NP_838353.1 30064182 1080182 complement(2935806..2937224) 1 NC_004741.1 residues 1 to 472 of 472 are 94.06 pct identical to residues 1 to 472 of 472 from Escherichia coli K-12 : B2841; low-affinity L-arabinose transport system proton symport protein 2937224 araE 1080182 araE Shigella flexneri 2a str. 2457T low-affinity L-arabinose transport system proton symport protein NP_838353.1 2935806 R 198215 CDS NP_838354.1 30064183 1079520 complement(2937539..2938300) 1 NC_004741.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase 2938300 kduD 1079520 kduD Shigella flexneri 2a str. 2457T 2-deoxy-D-gluconate 3-dehydrogenase NP_838354.1 2937539 R 198215 CDS NP_838355.1 30064184 1079316 complement(2938330..2939166) 1 NC_004741.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase 2939166 kduI 1079316 kduI Shigella flexneri 2a str. 2457T 5-keto-4-deoxyuronate isomerase NP_838355.1 2938330 R 198215 CDS NP_838356.1 30064185 1079318 complement(2939453..2940634) 1 NC_004741.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 2940634 yqeF 1079318 yqeF Shigella flexneri 2a str. 2457T acetyl-CoA acetyltransferase NP_838356.1 2939453 R 198215 CDS NP_838357.1 30064186 1078306 2941000..2942118 1 NC_004741.1 residues 1 to 372 of 372 are 99.19 pct identical to residues 38 to 409 of 409 from Escherichia coli K-12 : B2845; transporter protein 2942118 1078306 S3053 Shigella flexneri 2a str. 2457T transporter protein NP_838357.1 2941000 D 198215 CDS NP_838358.1 30064187 1079319 2942753..2943052 1 NC_004741.1 residues 1 to 99 of 99 are 100.00 pct identical to residues 1 to 99 of 99 from GenPept : >gb|AAL57580.1|AF453442_9 (AF453442) transposase 2 [Escherichia coli]; IS3 orfA 2943052 1079319 S3055 Shigella flexneri 2a str. 2457T IS3 orfA NP_838358.1 2942753 D 198215 CDS NP_838359.1 30064188 1079321 2943049..2943915 1 NC_004741.1 residues 1 to 288 of 288 are 99.30 pct identical to residues 1 to 288 of 288 from GenPept : >gb|AAL57519.1|AF453441_3 (AF453441) transposase 1 [Escherichia coli]; IS3 orfB 2943915 1079321 S3056 Shigella flexneri 2a str. 2457T IS3 orfB NP_838359.1 2943049 D 198215 CDS NP_838360.1 30064189 1079325 complement(2945154..2946143) 1 NC_004741.1 residues 5 to 326 of 329 are 92.54 pct identical to residues 4 to 325 of 327 from GenPept : >emb|CAD02863.1| (AL627277) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 2946143 1079325 S3059 Shigella flexneri 2a str. 2457T hypothetical protein NP_838360.1 2945154 R 198215 CDS NP_838361.1 30064190 1077055 complement(2946227..2946718) 1 NC_004741.1 residues 1 to 163 of 163 are 79.75 pct identical to residues 1 to 163 of 163 from GenPept : >emb|CAD02864.1| (AL627277) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 2946718 1077055 S3060 Shigella flexneri 2a str. 2457T hypothetical protein NP_838361.1 2946227 R 198215 CDS NP_838362.1 30064191 1079326 complement(2947016..2947762) 1 NC_004741.1 residues 17 to 116 of 248 are 40.77 pct identical to residues 19 to 116 of 280 from GenPept : >emb|CAD09973.1| (AL513384) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 2947762 1079326 S3062 Shigella flexneri 2a str. 2457T hypothetical protein NP_838362.1 2947016 R 198215 CDS NP_838363.1 30064192 1079327 complement(2948881..2949213) 1 NC_004741.1 no significant similarities; hypothetical protein 2949213 1079327 S3063 Shigella flexneri 2a str. 2457T hypothetical protein NP_838363.1 2948881 R 198215 CDS NP_838364.1 30064193 1079328 complement(2949332..2950942) 1 NC_004741.1 residues 1 to 511 of 536 are 96.67 pct identical to residues 1 to 511 of 548 from GenPept : >emb|CAD02867.1| (AL627277) possible integrase [Salmonella enterica subsp. enterica serovar Typhi]; integrase 2950942 1079328 S3064 Shigella flexneri 2a str. 2457T integrase NP_838364.1 2949332 R 198215 CDS NP_838365.1 30064194 1079329 complement(2951229..2952008) 1 NC_004741.1 residues 2 to 260 of 260 are 89.18 pct identical to residues 1 to 259 of 259 from Escherichia coli K-12 : B2865; lipoprotein 2952008 1079329 S3067 Shigella flexneri 2a str. 2457T lipoprotein NP_838365.1 2951229 R 198215 CDS NP_838366.1 30064195 1079331 2952399..2954696 1 NC_004741.1 molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 2954696 1079331 S3068 Shigella flexneri 2a str. 2457T xanthine dehydrogenase subunit XdhA NP_838366.1 2952399 D 198215 CDS NP_838367.1 30064196 1079320 2954707..2955585 1 NC_004741.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 2955585 ygeT 1079320 ygeT Shigella flexneri 2a str. 2457T xanthine dehydrogenase subunit XdhB NP_838367.1 2954707 D 198215 CDS NP_838368.1 30064197 1079332 2955582..2956061 1 NC_004741.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 2956061 1079332 S3070 Shigella flexneri 2a str. 2457T xanthine dehydrogenase subunit XdhC NP_838368.1 2955582 D 198215 CDS NP_838369.1 30064198 1079333 2956174..2956449 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 2956449 1079333 S3071 Shigella flexneri 2a str. 2457T IS1 orfA NP_838369.1 2956174 D 198215 CDS NP_838370.1 30064199 1079334 2956368..2956871 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 2956871 1079334 S3072 Shigella flexneri 2a str. 2457T IS1 orfB NP_838370.1 2956368 D 198215 CDS NP_838371.1 30064200 1080977 2957303..2958820 1 NC_004741.1 residues 1 to 505 of 505 are 99.00 pct identical to residues 1 to 505 of 505 from Escherichia coli K-12 : B2888; permease 2958820 ygfU 1080977 ygfU Shigella flexneri 2a str. 2457T permease NP_838371.1 2957303 D 198215 CDS NP_838372.1 30064201 1079336 2959070..2959618 1 NC_004741.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 2959618 1079336 S3074 Shigella flexneri 2a str. 2457T isopentenyl-diphosphate delta-isomerase NP_838372.1 2959070 D 198215 CDS NP_838373.1 30064202 1079763 complement(2959661..2961178) 1 NC_004741.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 2961178 lysS 1079763 lysS Shigella flexneri 2a str. 2457T lysyl-tRNA synthetase NP_838373.1 2959661 R 198215 CDS NP_838374.1 30064203 1079337 complement(join(2961188..2962210,2962212..2962286)) 1 NC_004741.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 2962286 prfB 1079337 prfB Shigella flexneri 2a str. 2457T peptide chain release factor 2 NP_838374.1 2961188 R 198215 CDS NP_838375.1 30064204 1079338 complement(2962377..2964110) 1 NC_004741.1 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 2964110 recJ 1079338 recJ Shigella flexneri 2a str. 2457T ssDNA exonuclease RecJ NP_838375.1 2962377 R 198215 CDS NP_838376.1 30064205 1079339 complement(2964116..2964826) 1 NC_004741.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 2964826 dsbC 1079339 dsbC Shigella flexneri 2a str. 2457T thiol:disulfide interchange protein DsbC NP_838376.1 2964116 R 198215 CDS NP_838377.1 30064206 1076571 complement(2964851..2965747) 1 NC_004741.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 2965747 xerD 1076571 xerD Shigella flexneri 2a str. 2457T site-specific tyrosine recombinase XerD NP_838377.1 2964851 R 198215 CDS NP_838378.1 30064207 1079340 2965859..2966380 1 NC_004741.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 2966380 fldB 1079340 fldB Shigella flexneri 2a str. 2457T flavodoxin FldB NP_838378.1 2965859 D 198215 CDS NP_838379.1 30064208 1079341 complement(2966420..2966827) 1 NC_004741.1 residues 1 to 135 of 135 are 99.25 pct identical to residues 1 to 135 of 135 from Escherichia coli K-12 : B2896; hypothetical protein 2966827 1079341 S3081 Shigella flexneri 2a str. 2457T hypothetical protein NP_838379.1 2966420 R 198215 CDS NP_838380.1 30064209 1079342 complement(2966808..2967074) 1 NC_004741.1 residues 1 to 88 of 88 are 100.00 pct identical to residues 1 to 88 of 88 from Escherichia coli K-12 : B2897; hypothetical protein 2967074 ygfY 1079342 ygfY Shigella flexneri 2a str. 2457T hypothetical protein NP_838380.1 2966808 R 198215 CDS NP_838381.1 30064210 1079343 2967317..2968297 1 NC_004741.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 2968297 ygfZ 1079343 ygfZ Shigella flexneri 2a str. 2457T global regulator NP_838381.1 2967317 D 198215 CDS NP_838382.1 30064211 1079344 complement(2968493..2969152) 1 NC_004741.1 residues 1 to 219 of 219 are 92.69 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B2899; oxidoreductase 2969152 1079344 S3084 Shigella flexneri 2a str. 2457T oxidoreductase NP_838382.1 2968493 R 198215 CDS NP_838383.1 30064212 1076479 2969671..2971104 1 NC_004741.1 residues 1 to 477 of 477 are 95.59 pct identical to residues 3 to 479 of 479 from Escherichia coli K-12 : B2901; 6-phospho-beta-glucosidase 2971104 bglA 1076479 bglA Shigella flexneri 2a str. 2457T 6-phospho-beta-glucosidase NP_838383.1 2969671 D 198215 CDS NP_838384.1 30064213 1079346 complement(2971161..2971904) 1 NC_004741.1 residues 1 to 247 of 247 are 99.19 pct identical to residues 1 to 247 of 247 from Escherichia coli K-12 : B2902; hypothetical protein 2971904 ygfF 1079346 ygfF Shigella flexneri 2a str. 2457T hypothetical protein NP_838384.1 2971161 R 198215 CDS NP_838385.1 30064214 1079347 complement(2972171..2975044) 1 NC_004741.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 2975044 gcvP 1079347 gcvP Shigella flexneri 2a str. 2457T glycine dehydrogenase NP_838385.1 2972171 R 198215 CDS NP_838386.1 30064215 1079349 complement(2975163..2975552) 1 NC_004741.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 2975552 gcvH 1079349 gcvH Shigella flexneri 2a str. 2457T glycine cleavage system protein H NP_838386.1 2975163 R 198215 CDS NP_838387.1 30064216 1079350 complement(2975576..2976670) 1 NC_004741.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 2976670 gcvT 1079350 gcvT Shigella flexneri 2a str. 2457T glycine cleavage system aminomethyltransferase T NP_838387.1 2975576 R 198215 CDS NP_838388.1 30064217 1079351 complement(2977118..2978320) 1 NC_004741.1 residues 1 to 400 of 400 are 97.50 pct identical to residues 1 to 400 of 400 from Escherichia coli K-12 : B2906; hypothetical protein 2978320 visC 1079351 visC Shigella flexneri 2a str. 2457T hypothetical protein NP_838388.1 2977118 R 198215 CDS NP_838389.1 30064218 1079352 complement(2978343..2979521) 1 NC_004741.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 2979521 ubiH 1079352 ubiH Shigella flexneri 2a str. 2457T 2-octaprenyl-6-methoxyphenyl hydroxylase NP_838389.1 2978343 R 198215 CDS NP_838390.1 30064219 1079353 complement(2979518..2980843) 1 NC_004741.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 2980843 pepP 1079353 pepP Shigella flexneri 2a str. 2457T proline aminopeptidase P II NP_838390.1 2979518 R 198215 CDS NP_838391.1 30064220 1079355 complement(2980869..2981447) 1 NC_004741.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 2981447 ygfB 1079355 ygfB Shigella flexneri 2a str. 2457T hypothetical protein NP_838391.1 2980869 R 198215 CDS NP_838392.1 30064221 1079356 2981615..2981944 1 NC_004741.1 residues 1 to 109 of 109 are 100.00 pct identical to residues 1 to 109 of 109 from Escherichia coli K-12 : B2910; Z-ring-associated protein 2981944 ygfE 1079356 ygfE Shigella flexneri 2a str. 2457T Z-ring-associated protein NP_838392.1 2981615 D 198215 CDS NP_838393.1 30064222 1079357 2982244..2982792 1 NC_004741.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 2982792 ygfA 1079357 ygfA Shigella flexneri 2a str. 2457T ligase NP_838393.1 2982244 D 198215 CDS NP_838394.1 30064223 1079696 complement(2983573..2984805) 1 NC_004741.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 2984805 serA 1079696 serA Shigella flexneri 2a str. 2457T D-3-phosphoglycerate dehydrogenase NP_838394.1 2983573 R 198215 CDS NP_838395.1 30064224 1079359 complement(2985061..2985720) 1 NC_004741.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 2985720 rpiA 1079359 rpiA Shigella flexneri 2a str. 2457T ribose-5-phosphate isomerase A NP_838395.1 2985061 R 198215 CDS NP_838396.1 30064225 1079361 2986103..2986996 1 NC_004741.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 2986996 iciA 1079361 iciA Shigella flexneri 2a str. 2457T chromosome replication initiation inhibitor protein NP_838396.1 2986103 D 198215 CDS NP_838397.1 30064226 1079363 2987200..2989344 1 NC_004741.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 2989344 sbm 1079363 sbm Shigella flexneri 2a str. 2457T methylmalonyl-CoA mutase NP_838397.1 2987200 D 198215 CDS NP_838398.1 30064227 1079365 2989337..2990332 1 NC_004741.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 2990332 ygfD 1079365 ygfD Shigella flexneri 2a str. 2457T arginine/ornithine transport system ATPase NP_838398.1 2989337 D 198215 CDS NP_838399.2 161486444 1079366 2990343..2991128 1 NC_004741.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 2991128 ygfG 1079366 ygfG Shigella flexneri 2a str. 2457T methylmalonyl-CoA decarboxylase NP_838399.2 2990343 D 198215 CDS NP_838400.1 30064229 1079367 complement(2992572..2993522) 1 NC_004741.1 residues 1 to 285 of 316 are 94.38 pct identical to residues 6 to 290 of 303 from Escherichia coli K-12 : B2921; LYSR-type transcriptional regulator 2993522 ygfI 1079367 ygfI Shigella flexneri 2a str. 2457T LYSR-type transcriptional regulator NP_838400.1 2992572 R 198215 CDS NP_838401.1 30064230 1079368 complement(2993689..2994429) 1 NC_004741.1 residues 1 to 246 of 246 are 94.71 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B2922; hypothetical protein 2994429 yggE 1079368 yggE Shigella flexneri 2a str. 2457T hypothetical protein NP_838401.1 2993689 R 198215 CDS NP_838402.1 30064231 1079369 complement(2994522..2995157) 1 NC_004741.1 Involved in the export of arginine; arginine exporter protein 2995157 yggA 1079369 yggA Shigella flexneri 2a str. 2457T arginine exporter protein NP_838402.1 2994522 R 198215 CDS NP_838403.1 30064232 1079370 complement(2995296..2996156) 1 NC_004741.1 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS 2996156 yggB 1079370 yggB Shigella flexneri 2a str. 2457T mechanosensitive channel MscS NP_838403.1 2995296 R 198215 CDS NP_838404.1 30064233 1079371 complement(2996347..2997426) 1 NC_004741.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 2997426 fba 1079371 fba Shigella flexneri 2a str. 2457T fructose-bisphosphate aldolase NP_838404.1 2996347 R 198215 CDS NP_838405.1 30064234 1079372 complement(2997641..2998804) 1 NC_004741.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 2998804 pgk 1079372 pgk Shigella flexneri 2a str. 2457T phosphoglycerate kinase NP_838405.1 2997641 R 198215 CDS NP_838406.1 30064235 1079373 complement(2998854..2999873) 1 NC_004741.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 2999873 epd 1079373 epd Shigella flexneri 2a str. 2457T erythrose 4-phosphate dehydrogenase NP_838406.1 2998854 R 198215 CDS NP_838407.1 30064236 1079374 3000407..3000676 1 NC_004741.1 residues 1 to 89 of 89 are 98.87 pct identical to residues 55 to 143 of 143 from GenPept : >gb|AAG58054.1|AE005523_3 (AE005523) orf; hypothetical protein [Escherichia coli O157:H7 EDL933]; DNA-binding protein 3000676 1079374 S3113 Shigella flexneri 2a str. 2457T DNA-binding protein NP_838407.1 3000407 D 198215 CDS NP_838408.1 30064237 1079375 3000699..3001277 1 NC_004741.1 residues 1 to 192 of 192 are 81.25 pct identical to residues 1 to 192 of 192 from GenPept : >gb|AAG58055.1|AE005523_4 (AE005523) orf; hypothetical protein [Escherichia coli O157:H7 EDL933]; inner membrane protein 3001277 1079375 S3114 Shigella flexneri 2a str. 2457T inner membrane protein NP_838408.1 3000699 D 198215 CDS NP_838409.1 30064238 1079377 3001278..3001586 1 NC_004741.1 residues 1 to 102 of 102 are 83.33 pct identical to residues 1 to 102 of 235 from GenPept : >gb|AAG58056.1|AE005523_5 (AE005523) orf; hypothetical protein [Escherichia coli O157:H7 EDL933]; lipoprotein 3001586 1079377 S3115 Shigella flexneri 2a str. 2457T lipoprotein NP_838409.1 3001278 D 198215 CDS NP_838410.1 30064239 1079378 3001587..3001985 1 NC_004741.1 residues 1 to 132 of 132 are 99.24 pct identical to residues 104 to 235 of 235 from GenPept : >gb|AAG58056.1|AE005523_5 (AE005523) orf; hypothetical protein [Escherichia coli O157:H7 EDL933]; lipoprotein 3001985 1079378 S3116 Shigella flexneri 2a str. 2457T lipoprotein NP_838410.1 3001587 D 198215 CDS NP_838411.1 30064240 1079379 3001973..3002650 1 NC_004741.1 residues 1 to 225 of 225 are 91.55 pct identical to residues 1 to 225 of 225 from GenPept : >gb|AAG58057.1|AE005523_6 (AE005523) ATP-binding protein of ABC transport system [Escherichia coli O157:H7 EDL933]; ATP-binding protein of ABC transport system 3002650 1079379 S3117 Shigella flexneri 2a str. 2457T ATP-binding protein of ABC transport system NP_838411.1 3001973 D 198215 CDS NP_838412.1 30064241 1079380 3002644..3003321 1 NC_004741.1 residues 1 to 225 of 225 are 90.22 pct identical to residues 1 to 225 of 225 from GenPept : >dbj|BAB37226.1| (AP002563) ABC-transporter ATP-binding subunit [Escherichia coli O157:H7]; ATP-binding protein of ABC transport system 3003321 1079380 S3118 Shigella flexneri 2a str. 2457T ATP-binding protein of ABC transport system NP_838412.1 3002644 D 198215 CDS NP_838413.1 30064242 1079382 complement(3004003..3004512) 1 NC_004741.1 residues 1 to 151 of 169 are 96.68 pct identical to residues 1 to 151 of 169 from Escherichia coli K-12 : B2929; DNA-binding transcriptional regulator 3004512 yggD 1079382 yggD Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator NP_838413.1 3004003 R 198215 CDS NP_838414.1 30064243 1079383 complement(3004534..3005499) 1 NC_004741.1 residues 1 to 321 of 321 are 99.37 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B2930; fructose-1,6-bisphosphatase II-like protein 3005499 yggF 1079383 yggF Shigella flexneri 2a str. 2457T fructose-1,6-bisphosphatase II-like protein NP_838414.1 3004534 R 198215 CDS NP_838415.1 30064244 1079384 complement(3005496..3006485) 1 NC_004741.1 residues 1 to 329 of 329 are 98.78 pct identical to residues 1 to 329 of 329 from Escherichia coli K-12 : B2931; oxidoreductase 3006485 1079384 S3122 Shigella flexneri 2a str. 2457T oxidoreductase NP_838415.1 3005496 R 198215 CDS NP_838416.1 30064245 1079386 complement(3006739..3007242) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 3007242 1079386 S3124 Shigella flexneri 2a str. 2457T IS1 orfB NP_838416.1 3006739 R 198215 CDS NP_838417.1 30064246 1079388 complement(3007161..3007436) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3007436 1079388 S3125 Shigella flexneri 2a str. 2457T IS1 orfA NP_838417.1 3007161 R 198215 CDS NP_838418.1 30064247 1079389 3007927..3008835 1 NC_004741.1 residues 32 to 302 of 302 are 48.89 pct identical to residues 32 to 303 of 308 from GenPept : >emb|CAC90171.1| (AJ414147) SPFH domain protein [Yersinia pestis]; serine protease 3008835 1079389 S3126 Shigella flexneri 2a str. 2457T serine protease NP_838418.1 3007927 D 198215 CDS NP_838419.1 30064248 1079392 complement(3008881..3010872) 1 NC_004741.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3010872 tktA 1079392 tktA Shigella flexneri 2a str. 2457T transketolase NP_838419.1 3008881 R 198215 CDS NP_838420.1 30064249 1079393 3011024..3011908 1 NC_004741.1 residues 1 to 294 of 294 are 92.85 pct identical to residues 1 to 294 of 294 from Escherichia coli K-12 : B2936; hypothetical protein 3011908 yggG 1079393 yggG Shigella flexneri 2a str. 2457T hypothetical protein NP_838420.1 3011024 D 198215 CDS NP_838421.1 30064250 1077797 complement(3012114..3013034) 1 NC_004741.1 catalyzes the formation of putrescine from agmatine; agmatinase 3013034 speB 1077797 speB Shigella flexneri 2a str. 2457T agmatinase NP_838421.1 3012114 R 198215 CDS NP_838422.1 30064251 1079395 complement(3013170..3013544) 1 NC_004741.1 residues 1 to 124 of 124 are 97.58 pct identical to residues 120 to 243 of 243 from GenPept : >gb|AAG58068.1|AE005524_4 (AE005524) Z4282 gene product [Escherichia coli O157:H7 EDL933]; lipoprotein 3013544 1079395 S3130 Shigella flexneri 2a str. 2457T lipoprotein NP_838422.1 3013170 R 198215 CDS NP_838423.1 30064252 1079397 complement(3013570..3014073) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 3014073 1079397 S3131 Shigella flexneri 2a str. 2457T IS1 orfB NP_838423.1 3013570 R 198215 CDS NP_838424.1 30064253 1079398 complement(3013992..3014267) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3014267 1079398 S3132 Shigella flexneri 2a str. 2457T IS1 orfA NP_838424.1 3013992 R 198215 CDS NP_838425.1 30064254 1079399 complement(3014414..3016390) 1 NC_004741.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 3016390 speA 1079399 speA Shigella flexneri 2a str. 2457T arginine decarboxylase NP_838425.1 3014414 R 198215 CDS NP_838426.1 30064255 1079400 complement(3016399..3016545) 1 NC_004741.1 residues 1 to 48 of 48 are 93.75 pct identical to residues 1 to 48 of 48 from Escherichia coli K-12 : B2939; hypothetical protein 3016545 yqgB 1079400 yqgB Shigella flexneri 2a str. 2457T hypothetical protein NP_838426.1 3016399 R 198215 CDS NP_838427.1 30064256 1076489 3016666..3016881 1 NC_004741.1 residues 1 to 71 of 71 are 77.46 pct identical to residues 1 to 71 of 71 from Escherichia coli K-12 : B2940; hypothetical protein 3016881 yqgC 1076489 yqgC Shigella flexneri 2a str. 2457T hypothetical protein NP_838427.1 3016666 D 198215 CDS NP_838428.1 30064257 1079401 complement(3016878..3017129) 1 NC_004741.1 residues 1 to 83 of 83 are 98.79 pct identical to residues 1 to 83 of 83 from Escherichia coli K-12 : B2941; hypothetical protein 3017129 yqgD 1079401 yqgD Shigella flexneri 2a str. 2457T hypothetical protein NP_838428.1 3016878 R 198215 CDS NP_838429.1 30064258 1079402 3017185..3018339 1 NC_004741.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3018339 metK 1079402 metK Shigella flexneri 2a str. 2457T S-adenosylmethionine synthetase NP_838429.1 3017185 D 198215 CDS NP_838430.1 30064259 1078092 3018815..3020170 1 NC_004741.1 residues 1 to 451 of 451 are 97.11 pct identical to residues 14 to 464 of 464 from Escherichia coli K-12 : B2943; major facilitator superfamily galactose-proton symporter 3020170 galP 1078092 galP Shigella flexneri 2a str. 2457T major facilitator superfamily galactose-proton symporter NP_838430.1 3018815 D 198215 CDS NP_838431.1 30064260 1079403 3020247..3020744 1 NC_004741.1 residues 1 to 165 of 165 are 98.78 pct identical to residues 1 to 165 of 165 from Escherichia coli K-12 : B2944; hypothetical protein 3020744 sprT 1079403 sprT Shigella flexneri 2a str. 2457T hypothetical protein NP_838431.1 3020247 D 198215 CDS NP_838432.1 30064261 1079405 3020839..3021546 1 NC_004741.1 residues 1 to 235 of 235 are 94.04 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B2945; DNA-specific endonuclease I 3021546 endA 1079405 endA Shigella flexneri 2a str. 2457T DNA-specific endonuclease I NP_838432.1 3020839 D 198215 CDS NP_838433.1 30064262 1079407 3021626..3022357 1 NC_004741.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3022357 yggJ 1079407 yggJ Shigella flexneri 2a str. 2457T 16S ribosomal RNA methyltransferase RsmE NP_838433.1 3021626 D 198215 CDS NP_838434.1 30064263 1079408 3022370..3023320 1 NC_004741.1 The second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3023320 gshB 1079408 gshB Shigella flexneri 2a str. 2457T glutathione synthetase NP_838434.1 3022370 D 198215 CDS NP_838435.2 161486443 1079409 3023429..3023992 1 NC_004741.1 residues 1 to 211 of 211 are 100.00 pct identical to residues 1 to 211 of 211 from Escherichia coli K-12 : B2948; hypothetical protein 3023992 yqgE 1079409 yqgE Shigella flexneri 2a str. 2457T hypothetical protein NP_838435.2 3023429 D 198215 CDS NP_838436.1 30064265 1079435 3023992..3024408 1 NC_004741.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3024408 yqgF 1079435 yqgF Shigella flexneri 2a str. 2457T Holliday junction resolvase-like protein NP_838436.1 3023992 D 198215 CDS NP_838437.1 30064266 1079411 complement(3024584..3025609) 1 NC_004741.1 residues 1 to 341 of 341 are 98.24 pct identical to residues 1 to 341 of 341 from Escherichia coli K-12 : B2950; transporter 3025609 yggR 1079411 yggR Shigella flexneri 2a str. 2457T transporter NP_838437.1 3024584 R 198215 CDS NP_838438.1 30064267 1079412 3025582..3026286 1 NC_004741.1 residues 1 to 234 of 234 are 93.16 pct identical to residues 1 to 234 of 234 from Escherichia coli K-12 : B2951; hypothetical protein 3026286 yggS 1079412 yggS Shigella flexneri 2a str. 2457T hypothetical protein NP_838438.1 3025582 D 198215 CDS NP_838439.1 30064268 1079413 3026304..3026870 1 NC_004741.1 residues 1 to 188 of 188 are 83.51 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 : B2952; resistance protein 3026870 yggT 1079413 yggT Shigella flexneri 2a str. 2457T resistance protein NP_838439.1 3026304 D 198215 CDS NP_838440.2 161486442 1079414 3026867..3027157 1 NC_004741.1 residues 1 to 100 of 100 are 85.00 pct identical to residues 1 to 100 of 100 from Escherichia coli K-12 : B2953; hypothetical protein 3027157 yggU 1079414 yggU Shigella flexneri 2a str. 2457T hypothetical protein NP_838440.2 3026867 D 198215 CDS NP_838441.1 30064270 1079415 3027165..3027758 1 NC_004741.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 3027758 yggV 1079415 yggV Shigella flexneri 2a str. 2457T deoxyribonucleotide triphosphate pyrophosphatase NP_838441.1 3027165 D 198215 CDS NP_838442.1 30064271 1079416 3027751..3028887 1 NC_004741.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3028887 yggW 1079416 yggW Shigella flexneri 2a str. 2457T coproporphyrinogen III oxidase NP_838442.1 3027751 D 198215 CDS NP_838443.1 30064272 1079418 3029201..3029554 1 NC_004741.1 residues 1 to 114 of 117 are 80.70 pct identical to residues 1 to 114 of 216 from NRprotein_Feb03 : >gb|AAF06334.1|AF193593_1 C4-dicarboxylate periplasmic binding protein precursor DctP [Klebsiella pneumoniae]; hypothetical protein 3029554 1079418 S3151 Shigella flexneri 2a str. 2457T hypothetical protein NP_838443.1 3029201 D 198215 CDS NP_838444.1 30064273 1079419 3029571..3030164 1 NC_004741.1 residues 1 to 191 of 197 are 52.60 pct identical to residues 116 to 307 of 312 from NRprotein_Feb03 : >ref|NP_762983.1| TRAP-type C4-dicarboxylate transport system, periplasmic component [Vibrio vulnificus CMCP6] gb|AAO07973.1|AE016811_214 TRAP-type C4-dicarboxylate transport system, periplasmic component [Vibrio vulnificus CMCP6]; hypothetical protein 3030164 1079419 S3152 Shigella flexneri 2a str. 2457T hypothetical protein NP_838444.1 3029571 D 198215 CDS NP_838445.1 30064274 1079420 3030209..3030712 1 NC_004741.1 residues 36 to 166 of 167 are 23.13 pct identical to residues 27 to 157 of 157 from Escherichia coli K-12 : B3577; hypothetical protein 3030712 1079420 S3153 Shigella flexneri 2a str. 2457T hypothetical protein NP_838445.1 3030209 D 198215 CDS NP_838446.1 30064275 1079421 complement(3031144..3031419) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3031419 1079421 S3154 Shigella flexneri 2a str. 2457T IS1 orfA NP_838446.1 3031144 R 198215 CDS NP_838447.1 30064276 1079422 3031476..3032777 1 NC_004741.1 residues 5 to 393 of 433 are 33.07 pct identical to residues 1 to 384 of 424 from Escherichia coli K-12 : B3578; hypothetical protein 3032777 1079422 S3155 Shigella flexneri 2a str. 2457T hypothetical protein NP_838447.1 3031476 D 198215 CDS NP_838448.1 30064277 1078051 complement(3032878..3033840) 1 NC_004741.1 residues 1 to 320 of 320 are 99.37 pct identical to residues 1 to 320 of 335 from Escherichia coli K-12 : B2956; alpha helix chain 3033840 yggM 1078051 yggM Shigella flexneri 2a str. 2457T alpha helix chain NP_838448.1 3032878 R 198215 CDS NP_838449.1 30064278 1079423 complement(3033957..3035003) 1 NC_004741.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 3035003 ansB 1079423 ansB Shigella flexneri 2a str. 2457T L-asparaginase II NP_838449.1 3033957 R 198215 CDS NP_838450.1 30064279 1079424 complement(3035179..3035895) 1 NC_004741.1 residues 1 to 238 of 238 are 99.57 pct identical to residues 2 to 239 of 239 from Escherichia coli K-12 : B2958; hypothetical protein 3035895 yggN 1079424 yggN Shigella flexneri 2a str. 2457T hypothetical protein NP_838450.1 3035179 R 198215 CDS NP_838451.2 161486441 1079425 complement(3036082..3036408) 1 NC_004741.1 residues 1 to 118 of 118 are 98.30 pct identical to residues 1 to 118 of 118 from Escherichia coli K-12 : B2959; hypothetical protein 3036408 yggL 1079425 yggL Shigella flexneri 2a str. 2457T hypothetical protein NP_838451.2 3036082 R 198215 CDS NP_838452.1 30064281 1077756 complement(3036408..3037127) 1 NC_004741.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3037127 trmB 1077756 trmB Shigella flexneri 2a str. 2457T tRNA (guanine-N(7)-)-methyltransferase NP_838452.1 3036408 R 198215 CDS NP_838453.1 30064282 1079426 3037288..3038340 1 NC_004741.1 residues 1 to 350 of 350 are 98.85 pct identical to residues 1 to 350 of 350 from Escherichia coli K-12 : B2961; involved in G.C -->T.A transversions; adenine DNA glycosylase 3038340 mutY 1079426 mutY Shigella flexneri 2a str. 2457T adenine DNA glycosylase NP_838453.1 3037288 D 198215 CDS NP_838454.1 30064283 1079427 3038368..3038643 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from Escherichia coli K-12 : B2962; hypothetical protein 3038643 yggX 1079427 yggX Shigella flexneri 2a str. 2457T hypothetical protein NP_838454.1 3038368 D 198215 CDS NP_838455.1 30064284 1079428 3038705..3039787 1 NC_004741.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3039787 mltC 1079428 mltC Shigella flexneri 2a str. 2457T murein transglycosylase C NP_838455.1 3038705 D 198215 CDS NP_838456.1 30064285 1079429 3039941..3041245 1 NC_004741.1 residues 1 to 434 of 434 are 100.00 pct identical to residues 1 to 434 of 434 from Escherichia coli K-12 : B2964; permease for nucleosides 3041245 nupG 1079429 nupG Shigella flexneri 2a str. 2457T permease for nucleosides NP_838456.1 3039941 D 198215 CDS NP_838457.1 30064286 1079430 complement(3041294..3043489) 1 NC_004741.1 residues 1 to 731 of 731 are 96.03 pct identical to residues 1 to 731 of 731 from Escherichia coli K-12 : B2965; ornithine decarboxylase 3043489 speC 1079430 speC Shigella flexneri 2a str. 2457T ornithine decarboxylase NP_838457.1 3041294 R 198215 CDS NP_838458.1 30064287 1079431 3043827..3044534 1 NC_004741.1 residues 1 to 235 of 235 are 76.59 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B2966; transporter 3044534 yqgA 1079431 yqgA Shigella flexneri 2a str. 2457T transporter NP_838458.1 3043827 D 198215 CDS NP_838459.1 30064288 1079433 3044913..3046175 1 NC_004741.1 residues 1 to 420 of 420 are 97.72 pct identical to residues 1 to 420 of 420 from NRprotein_Feb03 : >ref|NP_757064.1| Prophage P4 integrase [Escherichia coli CFT073] gb|AAN83638.1|AE016771_149 Prophage P4 integrase [Escherichia coli CFT073]; P4-type integrase 3046175 1079433 S4822 Shigella flexneri 2a str. 2457T P4-type integrase NP_838459.1 3044913 D 198215 CDS NP_838460.1 30064289 1079434 3046628..3050143 1 NC_004741.1 residues 1 to 1171 of 1171 are 92.99 pct identical to residues 1 to 1171 of 1171 from GenPept : >gb|AAL23307.1| (AE008910) superfamily I DNA helicases [Salmonella typhimurium LT2]; superfamily I DNA helicase 3050143 1079434 S3169 Shigella flexneri 2a str. 2457T superfamily I DNA helicase NP_838460.1 3046628 D 198215 CDS NP_838461.1 30064290 1079390 3051492..3052253 1 NC_004741.1 residues 1 to 253 of 253 are 75.88 pct identical to residues 148 to 400 of 400 from NRprotein_Feb03 : >dbj|BAA77991.1| traF [Plasmid R64] dbj|BAB91674.1| 99 pct identical to gp:AB021078_83[TraF of plasmid ColIb-P9] [Salmonella typhimurium]; hypothetical protein 3052253 1079390 S4823 Shigella flexneri 2a str. 2457T hypothetical protein NP_838461.1 3051492 D 198215 CDS NP_838462.1 30064291 1079436 3052614..3056471 1 NC_004741.1 residues 1 to 1285 of 1285 are 100.00 pct identical to residues 1 to 1285 of 1285 from NRprotein_Feb03 : >ref|NP_708742.1| exported serine protease SigA [Shigella flexneri 2a str. 301] gb|AAF67320.1|AF200692_1 exported serine protease SigA [Shigella flexneri 2a] gb|AAN44449.1|AE015310_3 exported serine protease SigA [Shigella flexneri 2a str. 301]; serine protease 3056471 sigA 1079436 sigA Shigella flexneri 2a str. 2457T serine protease NP_838462.1 3052614 D 198215 CDS NP_838463.1 30064292 1079437 3059545..3059763 1 NC_004741.1 residues 1 to 72 of 72 are 97.22 pct identical to residues 331 to 402 of 402 from GenPept : >gb|AAG18473.1|AF143819_2 (AF143819) transposase-like protein; TnpA [Escherichia coli]; hypothetical protein 3059763 1079437 S3177 Shigella flexneri 2a str. 2457T hypothetical protein NP_838463.1 3059545 D 198215 CDS NP_838464.1 30064293 1079438 complement(3059914..3063126) 1 NC_004741.1 residues 1 to 1070 of 1070 are 96.16 pct identical to residues 304 to 1373 of 1373 from GenPept : >gb|AAK00464.1| (AF200692) Pic [Shigella flexneri 2a]; serine protease precurser 3063126 pic 1079438 pic Shigella flexneri 2a str. 2457T serine protease precurser NP_838464.1 3059914 R 198215 CDS NP_838465.1 30064294 1079439 complement(3064760..3065593) 1 NC_004741.1 residues 1 to 277 of 277 are 100.00 pct identical to residues 226 to 502 of 502 from GenPept : >dbj|BAA84894.1| (AB024946) orf59 [Escherichia coli]; reverse transcriptase-like protein 3065593 1079439 S3180 Shigella flexneri 2a str. 2457T reverse transcriptase-like protein NP_838465.1 3064760 R 198215 CDS NP_838466.1 30064295 1079440 complement(3065587..3066267) 1 NC_004741.1 residues 1 to 208 of 226 are 95.19 pct identical to residues 1 to 208 of 376 from GenPept : >gb|AAC73361.1| (AE000133) orf, hypothetical protein [Escherichia coli K12]; reverse transcriptase-like protein 3066267 1079440 S3181 Shigella flexneri 2a str. 2457T reverse transcriptase-like protein NP_838466.1 3065587 R 198215 CDS NP_838467.1 30064296 1079441 complement(3067353..3067679) 1 NC_004741.1 residues 1 to 108 of 108 are 74.07 pct identical to residues 1 to 108 of 108 from GenPept : >gb|AAL67399.1|AF447814_67 (AF447814) TnpE-like protein [Escherichia coli]; IS629 orfA 3067679 1079441 S3184 Shigella flexneri 2a str. 2457T IS629 orfA NP_838467.1 3067353 R 198215 CDS NP_838468.1 30064297 1079442 complement(3067962..3068387) 1 NC_004741.1 residues 15 to 119 of 141 are 37.27 pct identical to residues 44 to 153 of 173 from GenPept : >gb|AAL08463.1|AF326777_38 (AF326777) unknown [Shigella flexneri 2a]; hypothetical protein 3068387 1079442 S3185 Shigella flexneri 2a str. 2457T hypothetical protein NP_838468.1 3067962 R 198215 CDS NP_838469.1 30064298 1079443 complement(3068384..3068767) 1 NC_004741.1 residues 1 to 127 of 127 are 100.00 pct identical to residues 1 to 127 of 127 from GenPept : >gb|AAK00467.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein 3068767 1079443 S3186 Shigella flexneri 2a str. 2457T hypothetical protein NP_838469.1 3068384 R 198215 CDS NP_838470.1 30064299 1079444 complement(3069140..3069739) 1 NC_004741.1 residues 80 to 199 of 199 are 100.00 pct identical to residues 1 to 120 of 120 from GenPept : >gb|AAK00468.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein 3069739 1079444 S3187 Shigella flexneri 2a str. 2457T hypothetical protein NP_838470.1 3069140 R 198215 CDS NP_838471.2 161486440 1079445 3070456..3070821 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3070821 1079445 S3188 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_838471.2 3070456 D 198215 CDS NP_838472.2 161486439 1079446 3070779..3071684 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3071684 1079446 S3189 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_838472.2 3070779 D 198215 CDS NP_838473.1 30064302 1079447 3073538..3073744 1 NC_004741.1 residues 1 to 68 of 68 are 89.70 pct identical to residues 25 to 92 of 92 from GenPept : >gb|AAL08466.1| (AF326777) unknown [Shigella flexneri 2a]; hypothetical protein 3073744 1079447 S3190 Shigella flexneri 2a str. 2457T hypothetical protein NP_838473.1 3073538 D 198215 CDS NP_838474.1 30064303 1079448 3073830..3074402 1 NC_004741.1 residues 19 to 190 of 190 are 92.44 pct identical to residues 1 to 172 of 172 from GenPept : >gb|AAK00471.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein 3074402 1079448 S3191 Shigella flexneri 2a str. 2457T hypothetical protein NP_838474.1 3073830 D 198215 CDS NP_838475.1 30064304 1079449 complement(3074404..3074688) 1 NC_004741.1 no significant similarities; hypothetical protein 3074688 1079449 S4825 Shigella flexneri 2a str. 2457T hypothetical protein NP_838475.1 3074404 R 198215 CDS NP_838476.1 30064305 1079450 3075971..3076990 1 NC_004741.1 residues 1 to 339 of 339 are 100.00 pct identical to residues 1 to 339 of 339 from NRprotein_Feb03 : >ref|NP_708763.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN44470.1|AE015312_3 orf, conserved hypothetical protein [Shigella flexneri 2a str. 301]; hypothetical protein 3076990 1079450 S4826 Shigella flexneri 2a str. 2457T hypothetical protein NP_838476.1 3075971 D 198215 CDS NP_838477.1 30064306 1079451 3077100..3077972 1 NC_004741.1 residues 1 to 290 of 290 are 99.65 pct identical to residues 1 to 290 of 290 from GenPept : >gb|AAK00473.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein 3077972 sap 1079451 sap Shigella flexneri 2a str. 2457T hypothetical protein NP_838477.1 3077100 D 198215 CDS NP_838478.1 30064307 1079452 3078306..3079199 1 NC_004741.1 residues 1 to 293 of 297 are 64.16 pct identical to residues 53 to 344 of 1091 from Escherichia coli K-12 : B2000; similar to adhesin; outer membrane fluffing protein 3079199 1079452 S3194 Shigella flexneri 2a str. 2457T outer membrane fluffing protein NP_838478.1 3078306 D 198215 CDS NP_838479.1 30064308 1079668 3079305..3081425 1 NC_004741.1 residues 1 to 706 of 706 are 92.77 pct identical to residues 386 to 1091 of 1091 from Escherichia coli K-12 : B2000; similar to adhesin; outer membrane fluffing protein 3081425 1079668 S3195 Shigella flexneri 2a str. 2457T outer membrane fluffing protein NP_838479.1 3079305 D 198215 CDS NP_838480.1 30064309 1076492 3081546..3084062 1 NC_004741.1 residues 1 to 507 of 838 are 85.99 pct identical to residues 3 to 509 of 512 from Escherichia coli K-12 : B2001; hypothetical protein 3084062 1076492 S3196 Shigella flexneri 2a str. 2457T hypothetical protein NP_838480.1 3081546 D 198215 CDS NP_838481.1 30064310 1079453 3084138..3084593 1 NC_004741.1 residues 9 to 151 of 151 are 99.30 pct identical to residues 1 to 143 of 143 from GenPept : >gb|AAK00476.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein 3084593 1079453 S3197 Shigella flexneri 2a str. 2457T hypothetical protein NP_838481.1 3084138 D 198215 CDS NP_838482.1 30064311 1079454 3085004..3085822 1 NC_004741.1 residues 1 to 272 of 272 are 89.37 pct identical to residues 1 to 273 of 273 from GenPept : >dbj|BAB36224.1| (AP002559) hypothetical protein [Escherichia coli O157:H7]; hypothetical protein 3085822 1079454 S3199 Shigella flexneri 2a str. 2457T hypothetical protein NP_838482.1 3085004 D 198215 CDS NP_838483.1 30064312 1079455 3086164..3086637 1 NC_004741.1 residues 1 to 157 of 157 are 99.36 pct identical to residues 115 to 271 of 271 from GenPept : >gb|AAK00478.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein 3086637 1079455 S3200 Shigella flexneri 2a str. 2457T hypothetical protein NP_838483.1 3086164 D 198215 CDS NP_838484.1 30064313 1079456 3086638..3087129 1 NC_004741.1 residues 16 to 163 of 163 are 85.81 pct identical to residues 1 to 148 of 148 from Escherichia coli K-12 : B2002; RADC family DNA repair protein 3087129 yeeS 1079456 yeeS Shigella flexneri 2a str. 2457T RADC family DNA repair protein NP_838484.1 3086638 D 198215 CDS NP_838485.1 30064314 1079457 3087216..3087437 1 NC_004741.1 residues 1 to 73 of 73 are 93.15 pct identical to residues 1 to 73 of 73 from Escherichia coli K-12 : B2003; hypothetical protein 3087437 yeeT 1079457 yeeT Shigella flexneri 2a str. 2457T hypothetical protein NP_838485.1 3087216 D 198215 CDS NP_838486.1 30064315 1079458 3087517..3087894 1 NC_004741.1 residues 1 to 107 of 125 are 94.39 pct identical to residues 1 to 107 of 122 from Escherichia coli K-12 : B2004; structural protein 3087894 yeeU 1079458 yeeU Shigella flexneri 2a str. 2457T structural protein NP_838486.1 3087517 D 198215 CDS NP_838487.1 30064316 1079459 3087941..3088318 1 NC_004741.1 residues 1 to 124 of 125 are 85.48 pct identical to residues 1 to 124 of 124 from Escherichia coli K-12 : B2005; hypothetical protein 3088318 yeeV 1079459 yeeV Shigella flexneri 2a str. 2457T hypothetical protein NP_838487.1 3087941 D 198215 CDS NP_838488.1 30064317 1079460 3088315..3088803 1 NC_004741.1 residues 5 to 52 of 162 are 79.16 pct identical to residues 2 to 49 of 64 from Escherichia coli K-12 : B2006; hypothetical protein 3088803 yeeW 1079460 yeeW Shigella flexneri 2a str. 2457T hypothetical protein NP_838488.1 3088315 D 198215 CDS NP_838489.1 30064318 1079463 3089105..3089947 1 NC_004741.1 residues 1 to 280 of 280 are 100.00 pct identical to residues 1 to 280 of 280 from GenPept : >gb|AAK00485.1| (AF200692) unknown [Shigella flexneri 2a]; hypothetical protein 3089947 1079463 S3207 Shigella flexneri 2a str. 2457T hypothetical protein NP_838489.1 3089105 D 198215 CDS NP_838490.1 30064319 1079464 3091372..3091671 1 NC_004741.1 residues 1 to 99 of 99 are 100.00 pct identical to residues 1 to 99 of 99 from GenPept : >gb|AAL57580.1|AF453442_9 (AF453442) transposase 2 [Escherichia coli]; IS3 orfA 3091671 1079464 S3209 Shigella flexneri 2a str. 2457T IS3 orfA NP_838490.1 3091372 D 198215 CDS NP_838491.1 30064320 1079465 3091668..3092534 1 NC_004741.1 residues 1 to 288 of 288 are 99.30 pct identical to residues 1 to 288 of 288 from GenPept : >gb|AAL57519.1|AF453441_3 (AF453441) transposase 1 [Escherichia coli]; IS3 orfB 3092534 1079465 S3210 Shigella flexneri 2a str. 2457T IS3 orfB NP_838491.1 3091668 D 198215 CDS NP_838492.1 30064321 1079466 complement(3093171..3093410) 1 NC_004741.1 no significant similarities; hypothetical protein 3093410 1079466 S3211 Shigella flexneri 2a str. 2457T hypothetical protein NP_838492.1 3093171 R 198215 CDS NP_838493.1 30064322 1079467 complement(3093545..3094150) 1 NC_004741.1 no significant similarities; hypothetical protein 3094150 1079467 S3212 Shigella flexneri 2a str. 2457T hypothetical protein NP_838493.1 3093545 R 198215 CDS NP_838494.1 30064323 1076474 complement(3094265..3094768) 1 NC_004741.1 residues 3 to 97 of 97 are 83.15 pct identical to residues 73 to 167 of 167 from GenPept : >gb|AAK18549.1|AF348706_238 (AF348706) iso-IS1 orfB [Shigella flexneri]; IS1 orfB 3094768 1076474 S3213 Shigella flexneri 2a str. 2457T IS1 orfB NP_838494.1 3094265 R 198215 CDS NP_838495.1 30064324 1079468 complement(3094687..3094962) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3094962 1079468 S3214 Shigella flexneri 2a str. 2457T IS1 orfA NP_838495.1 3094687 R 198215 CDS NP_838496.1 30064325 1079470 complement(3096365..3097951) 1 NC_004741.1 residues 1 to 528 of 528 are 79.82 pct identical to residues 1 to 560 of 560 from Escherichia coli K-12 : B2975; permease 3097951 yghK 1079470 yghK Shigella flexneri 2a str. 2457T permease NP_838496.1 3096365 R 198215 CDS NP_838497.1 30064326 1079471 complement(3098306..3100477) 1 NC_004741.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 3100477 glcB 1079471 glcB Shigella flexneri 2a str. 2457T malate synthase G NP_838497.1 3098306 R 198215 CDS NP_838498.1 30064327 1079472 complement(3100499..3100903) 1 NC_004741.1 residues 1 to 118 of 134 are 100.00 pct identical to residues 1 to 118 of 134 from Escherichia coli K-12 : B2977; hypothetical protein 3100903 glcG 1079472 glcG Shigella flexneri 2a str. 2457T hypothetical protein NP_838498.1 3100499 R 198215 CDS NP_838499.1 30064328 1079476 3104940..3105710 1 NC_004741.1 residues 1 to 252 of 256 are 98.41 pct identical to residues 1 to 252 of 254 from Escherichia coli K-12 : B2980; DNA-binding transcriptional regulator GlcC 3105710 glcC 1079476 glcC Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator GlcC NP_838499.1 3104940 D 198215 CDS NP_838500.1 30064329 1079478 3107379..3109067 1 NC_004741.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3109067 1079478 S3222 Shigella flexneri 2a str. 2457T acyl-CoA synthetase NP_838500.1 3107379 D 198215 CDS NP_838501.1 30064330 1080726 3109082..3109978 1 NC_004741.1 residues 1 to 281 of 298 are 32.74 pct identical to residues 11 to 288 of 317 from GenPept : >gb|AAK23148.1| (AE005794) conserved hypothetical protein [Caulobacter crescentus CB15]; hypothetical protein 3109978 1080726 S3223 Shigella flexneri 2a str. 2457T hypothetical protein NP_838501.1 3109082 D 198215 CDS NP_838502.1 30064331 1079479 3110011..3110259 1 NC_004741.1 no significant similarities; hypothetical protein 3110259 1079479 S3224 Shigella flexneri 2a str. 2457T hypothetical protein NP_838502.1 3110011 D 198215 CDS NP_838503.1 30064332 1079486 3110259..3110609 1 NC_004741.1 residues 1 to 109 of 116 are 41.28 pct identical to residues 1 to 109 of 404 from GenPept : >gb|AAK23146.1| (AE005794) aminotransferase, class II [Caulobacter crescentus CB15]; partial; class II aminotransferase 3110609 1079486 S3225 Shigella flexneri 2a str. 2457T class II aminotransferase NP_838503.1 3110259 D 198215 CDS NP_838504.1 30064333 1079480 3110642..3111430 1 NC_004741.1 residues 2 to 260 of 262 are 51.53 pct identical to residues 130 to 389 of 404 from GenPept : >gb|AAK23146.1| (AE005794) aminotransferase, class II [Caulobacter crescentus CB15]; partial; class II aminotransferase 3111430 1079480 S3226 Shigella flexneri 2a str. 2457T class II aminotransferase NP_838504.1 3110642 D 198215 CDS NP_838505.1 30064334 1079482 complement(3111466..3112545) 1 NC_004741.1 residues 3 to 352 of 359 are 28.61 pct identical to residues 4 to 354 of 358 from GenPept : >emb|CAC92669.1| (AJ414157) membrane protein [Yersinia pestis]; hypothetical protein 3112545 1079482 S3227 Shigella flexneri 2a str. 2457T hypothetical protein NP_838505.1 3111466 R 198215 CDS NP_838506.1 30064335 1079484 complement(3112542..3113612) 1 NC_004741.1 residues 34 to 342 of 356 are 28.66 pct identical to residues 33 to 350 of 372 from GenPept : >gb|AAG07215.1|AE004800_4 (AE004800) conserved hypothetical protein [Pseudomonas aeruginosa]; hypothetical protein 3113612 1079484 S3228 Shigella flexneri 2a str. 2457T hypothetical protein NP_838506.1 3112542 R 198215 CDS NP_838507.1 30064336 1076473 complement(3113643..3114203) 1 NC_004741.1 residues 20 to 184 of 186 are 56.36 pct identical to residues 20 to 183 of 184 from GenPept : >gb|AAL01384.1|AF407017_1 (AF407017) periplasmic protein [Escherichia coli]; hypothetical protein 3114203 1076473 S3229 Shigella flexneri 2a str. 2457T hypothetical protein NP_838507.1 3113643 R 198215 CDS NP_838508.1 30064337 1079485 complement(3114215..3115039) 1 NC_004741.1 no significant similarities; hypothetical protein 3115039 1079485 S3230 Shigella flexneri 2a str. 2457T hypothetical protein NP_838508.1 3114215 R 198215 CDS NP_838509.1 30064338 1078248 complement(3115039..3116388) 1 NC_004741.1 residues 45 to 355 of 449 are 92.92 pct identical to residues 15 to 325 of 325 from Escherichia coli K-12 : B2983; hypothetical protein 3116388 yghQ 1078248 yghQ Shigella flexneri 2a str. 2457T hypothetical protein NP_838509.1 3115039 R 198215 CDS NP_838510.1 30064339 1079487 complement(3116434..3117192) 1 NC_004741.1 residues 1 to 252 of 252 are 92.85 pct identical to residues 1 to 252 of 252 from Escherichia coli K-12 : B2984; hypothetical protein 3117192 yghR 1079487 yghR Shigella flexneri 2a str. 2457T hypothetical protein NP_838510.1 3116434 R 198215 CDS NP_838511.1 30064340 1079549 complement(3117224..3117937) 1 NC_004741.1 residues 1 to 237 of 237 are 97.46 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B2985; hypothetical protein 3117937 yghS 1079549 yghS Shigella flexneri 2a str. 2457T hypothetical protein NP_838511.1 3117224 R 198215 CDS NP_838512.1 30064341 1079488 3118111..3118803 1 NC_004741.1 residues 1 to 230 of 230 are 99.56 pct identical to residues 1 to 230 of 230 from Escherichia coli K-12 : B2986; hypothetical protein 3118803 yghT 1079488 yghT Shigella flexneri 2a str. 2457T hypothetical protein NP_838512.1 3118111 D 198215 CDS NP_838513.1 30064342 1079489 complement(3118852..3120351) 1 NC_004741.1 residues 1 to 499 of 499 are 89.17 pct identical to residues 1 to 499 of 499 from Escherichia coli K-12 : B2987; low-affinity phosphate transport protein 3120351 pitB 1079489 pitB Shigella flexneri 2a str. 2457T low-affinity phosphate transport protein NP_838513.1 3118852 R 198215 CDS NP_838514.1 30064343 1079490 complement(3120643..3122502) 1 NC_004741.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 3122502 gsp 1079490 gsp Shigella flexneri 2a str. 2457T bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase NP_838514.1 3120643 R 198215 CDS NP_838515.1 30064344 1079491 3122659..3123573 1 NC_004741.1 YghU; B2989; one of eight glutathione transferase proteins from E. coli; glutathione S-transferase 3123573 1079491 S3237 Shigella flexneri 2a str. 2457T glutathione S-transferase NP_838515.1 3122659 D 198215 CDS NP_838516.1 30064345 1079492 complement(3123696..3123944) 1 NC_004741.1 residues 1 to 82 of 82 are 100.00 pct identical to residues 1 to 82 of 82 from Escherichia coli K-12 : B2990; may effect maturation of large subunit of hydrogenase-2; hydrogenase 2 accessory protein HypG 3123944 hybG 1079492 hybG Shigella flexneri 2a str. 2457T hydrogenase 2 accessory protein HypG NP_838516.1 3123696 R 198215 CDS NP_838517.1 30064346 1079493 complement(3124078..3124419) 1 NC_004741.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 3124419 hypA 1079493 hypA Shigella flexneri 2a str. 2457T hydrogenase nickel incorporation protein HybF NP_838517.1 3124078 R 198215 CDS NP_838518.1 30064347 1079494 complement(3124412..3124900) 1 NC_004741.1 residues 1 to 162 of 162 are 91.97 pct identical to residues 1 to 162 of 162 from Escherichia coli K-12 : B2992; hydrogenase 2-specific chaperone 3124900 hybE 1079494 hybE Shigella flexneri 2a str. 2457T hydrogenase 2-specific chaperone NP_838518.1 3124412 R 198215 CDS NP_838519.1 30064348 1079495 complement(3124893..3125387) 1 NC_004741.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 3125387 hybD 1079495 hybD Shigella flexneri 2a str. 2457T hydrogenase 2 maturation endopeptidase NP_838519.1 3124893 R 198215 CDS NP_838520.1 30064349 1079496 complement(3125387..3127090) 1 NC_004741.1 involved in hydrogen uptake; hydrogenase 2 large subunit 3127090 hybC 1079496 hybC Shigella flexneri 2a str. 2457T hydrogenase 2 large subunit NP_838520.1 3125387 R 198215 CDS NP_838521.1 30064350 1079497 complement(3127087..3128265) 1 NC_004741.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit 3128265 hybB 1079497 hybB Shigella flexneri 2a str. 2457T hydrogenase 2 b cytochrome subunit NP_838521.1 3127087 R 198215 CDS NP_838522.1 30064351 1079498 complement(3128255..3129241) 1 NC_004741.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 3129241 hybA 1079498 hybA Shigella flexneri 2a str. 2457T hydrogenase 2 protein HybA NP_838522.1 3128255 R 198215 CDS NP_838523.1 30064352 1079503 complement(3129244..3130362) 1 NC_004741.1 involved in hydrogen uptake; hydrogenase 2 small subunit 3130362 1079503 S3245 Shigella flexneri 2a str. 2457T hydrogenase 2 small subunit NP_838523.1 3129244 R 198215 CDS NP_838524.1 30064353 1079499 complement(3130551..3130838) 1 NC_004741.1 residues 1 to 95 of 95 are 100.00 pct identical to residues 1 to 95 of 95 from Escherichia coli K-12 : B2998; hypothetical protein 3130838 1079499 S3246 Shigella flexneri 2a str. 2457T hypothetical protein NP_838524.1 3130551 R 198215 CDS NP_838525.1 30064354 1079500 complement(3130957..3131367) 1 NC_004741.1 residues 1 to 136 of 136 are 98.52 pct identical to residues 1 to 136 of 136 from Escherichia coli K-12 : B2999; hypothetical protein 3131367 1079500 S3247 Shigella flexneri 2a str. 2457T hypothetical protein NP_838525.1 3130957 R 198215 CDS NP_838526.1 30064355 1079502 3132001..3133041 1 NC_004741.1 residues 1 to 346 of 346 are 99.42 pct identical to residues 1 to 346 of 346 from Escherichia coli K-12 : B3001; aldo-keto reductase 3133041 1079502 S3249 Shigella flexneri 2a str. 2457T aldo-keto reductase NP_838526.1 3132001 D 198215 CDS NP_838527.1 30064356 1079504 complement(3133081..3133575) 1 NC_004741.1 residues 1 to 164 of 164 are 92.07 pct identical to residues 1 to 164 of 164 from Escherichia coli K-12 : B3002; hypothetical protein 3133575 yqhA 1079504 yqhA Shigella flexneri 2a str. 2457T hypothetical protein NP_838527.1 3133081 R 198215 CDS NP_838528.1 30064357 1079505 3133766..3134650 1 NC_004741.1 residues 1 to 294 of 294 are 93.87 pct identical to residues 1 to 294 of 294 from Escherichia coli K-12 : B3003; oxidoreductase 3134650 yghA 1079505 yghA Shigella flexneri 2a str. 2457T oxidoreductase NP_838528.1 3133766 D 198215 CDS NP_838529.1 30064358 1079506 3134826..3135071 1 NC_004741.1 residues 1 to 81 of 81 are 100.00 pct identical to residues 1 to 81 of 81 from Escherichia coli K-12 : B3004; hypothetical protein 3135071 1079506 S3252 Shigella flexneri 2a str. 2457T hypothetical protein NP_838529.1 3134826 D 198215 CDS NP_838530.1 30064359 1079507 complement(3134922..3135347) 1 NC_004741.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 3135347 exbD 1079507 exbD Shigella flexneri 2a str. 2457T biopolymer transport protein ExbD NP_838530.1 3134922 R 198215 CDS NP_838531.1 30064360 1080948 complement(3135354..3136088) 1 NC_004741.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 3136088 exbB 1080948 exbB Shigella flexneri 2a str. 2457T biopolymer transport protein ExbB NP_838531.1 3135354 R 198215 CDS NP_838532.1 30064361 1079508 complement(3136081..3136236) 1 NC_004741.1 residues 1 to 51 of 51 are 100.00 pct identical to residues 1 to 51 of 51 from Escherichia coli K-12 : B3007; hypothetical protein 3136236 1079508 S3255 Shigella flexneri 2a str. 2457T hypothetical protein NP_838532.1 3136081 R 198215 CDS NP_838533.1 30064362 1079509 3136340..3137527 1 NC_004741.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3137527 metC 1079509 metC Shigella flexneri 2a str. 2457T cystathionine beta-lyase NP_838533.1 3136340 D 198215 CDS NP_838534.1 30064363 1079510 3137667..3138326 1 NC_004741.1 residues 1 to 219 of 219 are 84.01 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 : B3009; hypothetical protein 3138326 yghB 1079510 yghB Shigella flexneri 2a str. 2457T hypothetical protein NP_838534.1 3137667 D 198215 CDS NP_838535.1 30064364 1079512 complement(3138366..3139493) 1 NC_004741.1 residues 1 to 375 of 375 are 99.73 pct identical to residues 1 to 375 of 375 from Escherichia coli K-12 : B3010; ARAC-type regulatory protein 3139493 yqhC 1079512 yqhC Shigella flexneri 2a str. 2457T ARAC-type regulatory protein NP_838535.1 3138366 R 198215 CDS NP_838536.1 30064365 1079513 3139459..3140622 1 NC_004741.1 residues 1 to 387 of 387 are 99.48 pct identical to residues 1 to 387 of 387 from Escherichia coli K-12 : B3011; oxidoreductase 3140622 yqhD 1079513 yqhD Shigella flexneri 2a str. 2457T oxidoreductase NP_838536.1 3139459 D 198215 CDS NP_838537.2 161486438 1077738 3140727..3141554 1 NC_004741.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3141554 dkgA 1077738 dkgA Shigella flexneri 2a str. 2457T 2,5-diketo-D-gluconate reductase A NP_838537.2 3140727 D 198215 CDS NP_838538.1 30064367 1077754 3141754..3142680 1 NC_004741.1 residues 1 to 308 of 308 are 95.46 pct identical to residues 1 to 309 of 309 from Escherichia coli K-12 : B3013; hypothetical protein 3142680 yqhG 1077754 yqhG Shigella flexneri 2a str. 2457T hypothetical protein NP_838538.1 3141754 D 198215 CDS NP_838539.1 30064368 1079514 3142731..3142988 1 NC_004741.1 residues 1 to 85 of 85 are 100.00 pct identical to residues 1 to 85 of 85 from Escherichia coli K-12 : B3014; outer membrane lipoprotein 3142988 yqhH 1079514 yqhH Shigella flexneri 2a str. 2457T outer membrane lipoprotein NP_838539.1 3142731 D 198215 CDS NP_838540.1 30064369 1079515 complement(3143031..3144272) 1 NC_004741.1 residues 1 to 413 of 413 are 99.51 pct identical to residues 1 to 413 of 413 from Escherichia coli K-12 : B3015; hypothetical protein 3144272 1079515 S3263 Shigella flexneri 2a str. 2457T hypothetical protein NP_838540.1 3143031 R 198215 CDS NP_838541.1 30064370 1079517 complement(3145361..3146773) 1 NC_004741.1 residues 1 to 470 of 470 are 92.34 pct identical to residues 1 to 470 of 470 from Escherichia coli K-12 : B3017; repressor protein for FtsI 3146773 sufI 1079517 sufI Shigella flexneri 2a str. 2457T repressor protein for FtsI NP_838541.1 3145361 R 198215 CDS NP_838542.1 30064371 1079518 complement(3146848..3147585) 1 NC_004741.1 residues 1 to 245 of 245 are 94.69 pct identical to residues 1 to 245 of 245 from Escherichia coli K-12 : B3018; 1-acyl-sn-glycerol-3-phosphate acyltransferase 3147585 plsC 1079518 plsC Shigella flexneri 2a str. 2457T 1-acyl-sn-glycerol-3-phosphate acyltransferase NP_838542.1 3146848 R 198215 CDS NP_838543.1 30064372 1076484 complement(3147819..3150077) 1 NC_004741.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 3150077 parC 1076484 parC Shigella flexneri 2a str. 2457T DNA topoisomerase IV subunit A NP_838543.1 3147819 R 198215 CDS NP_838544.1 30064373 1079521 complement(3150623..3151105) 1 NC_004741.1 residues 1 to 160 of 160 are 97.50 pct identical to residues 1 to 160 of 160 from Escherichia coli K-12 : B3023; hypothetical protein 3151105 1079521 S3268 Shigella flexneri 2a str. 2457T hypothetical protein NP_838544.1 3150623 R 198215 CDS NP_838545.1 30064374 1077781 complement(3151158..3151550) 1 NC_004741.1 residues 1 to 130 of 130 are 99.23 pct identical to residues 1 to 130 of 130 from Escherichia coli K-12 : B3024; hypothetical protein 3151550 ygiW 1077781 ygiW Shigella flexneri 2a str. 2457T hypothetical protein NP_838545.1 3151158 R 198215 CDS NP_838546.1 30064375 1077766 3151702..3152361 1 NC_004741.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3152361 ygiX 1077766 ygiX Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator QseB NP_838546.1 3151702 D 198215 CDS NP_838547.1 30064376 1079522 3152358..3153632 1 NC_004741.1 residues 1 to 424 of 424 are 89.08 pct identical to residues 1 to 449 of 449 from Escherichia coli K-12 : B3026; sensor protein QseC 3153632 ygiY 1079522 ygiY Shigella flexneri 2a str. 2457T sensor protein QseC NP_838547.1 3152358 D 198215 CDS NP_838548.1 30064377 1079525 complement(3153678..3154010) 1 NC_004741.1 residues 1 to 110 of 110 are 86.36 pct identical to residues 1 to 110 of 110 from Escherichia coli K-12 : B3027; hypothetical protein 3154010 1079525 S3272 Shigella flexneri 2a str. 2457T hypothetical protein NP_838548.1 3153678 R 198215 CDS NP_838549.1 30064378 1079526 3154329..3154910 1 NC_004741.1 residues 1 to 193 of 193 are 98.44 pct identical to residues 1 to 193 of 193 from Escherichia coli K-12 : B3028; modulator of drug activity B 3154910 mdaB 1079526 mdaB Shigella flexneri 2a str. 2457T modulator of drug activity B NP_838549.1 3154329 D 198215 CDS NP_838550.1 30064379 1079527 3154941..3155255 1 NC_004741.1 residues 1 to 104 of 104 are 100.00 pct identical to residues 1 to 104 of 104 from Escherichia coli K-12 : B3029; hypothetical protein 3155255 ygiN 1079527 ygiN Shigella flexneri 2a str. 2457T hypothetical protein NP_838550.1 3154941 D 198215 CDS NP_838551.1 30064380 1079528 complement(3155303..3157195) 1 NC_004741.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3157195 parE 1079528 parE Shigella flexneri 2a str. 2457T DNA topoisomerase IV subunit B NP_838551.1 3155303 R 198215 CDS NP_838552.1 30064381 1079529 complement(3157224..3157805) 1 NC_004741.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA 3157805 yqiA 1079529 yqiA Shigella flexneri 2a str. 2457T esterase YqiA NP_838552.1 3157224 R 198215 CDS NP_838553.1 30064382 1077772 complement(3157805..3158632) 1 NC_004741.1 residues 1 to 275 of 275 are 95.99 pct identical to residues 1 to 275 of 275 from Escherichia coli K-12 : B3032; cyclic 3',5'-adenosine monophosphate phosphodiesterase 3158632 icc 1077772 icc Shigella flexneri 2a str. 2457T cyclic 3',5'-adenosine monophosphate phosphodiesterase NP_838553.1 3157805 R 198215 CDS NP_838554.1 30064383 1079530 complement(3158657..3159079) 1 NC_004741.1 residues 1 to 140 of 140 are 100.00 pct identical to residues 1 to 140 of 140 from Escherichia coli K-12 : B3033; hypothetical protein 3159079 yqiB 1079530 yqiB Shigella flexneri 2a str. 2457T hypothetical protein NP_838554.1 3158657 R 198215 CDS NP_838555.1 30064384 1080971 complement(3159080..3159709) 1 NC_004741.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase NudF 3159709 nudF 1080971 nudF Shigella flexneri 2a str. 2457T ADP-ribose pyrophosphatase NudF NP_838555.1 3159080 R 198215 CDS NP_838556.1 30064385 1080970 3159914..3161395 1 NC_004741.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3161395 tolC 1080970 tolC Shigella flexneri 2a str. 2457T outer membrane channel protein NP_838556.1 3159914 D 198215 CDS NP_838557.1 30064386 1080969 3161395..3161655 1 NC_004741.1 residues 1 to 86 of 86 are 100.00 pct identical to residues 1 to 86 of 86 from Escherichia coli K-12 : B3036; hypothetical protein 3161655 ygiA 1080969 ygiA Shigella flexneri 2a str. 2457T hypothetical protein NP_838557.1 3161395 D 198215 CDS NP_838558.2 161486437 1079531 3161543..3162214 1 NC_004741.1 residues 1 to 234 of 234 are 92.30 pct identical to residues 1 to 234 of 234 from Escherichia coli K-12 : B3037; hypothetical protein 3162214 ygiB 1079531 ygiB Shigella flexneri 2a str. 2457T hypothetical protein NP_838558.2 3161543 D 198215 CDS NP_838559.1 30064388 1079532 3162220..3163380 1 NC_004741.1 residues 1 to 386 of 386 are 99.74 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 : B3038; synthetase/amidase 3163380 ygiC 1079532 ygiC Shigella flexneri 2a str. 2457T synthetase/amidase NP_838559.1 3162220 D 198215 CDS NP_838560.1 30064389 1079533 complement(3163418..3164233) 1 NC_004741.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein 3164233 ygiD 1079533 ygiD Shigella flexneri 2a str. 2457T hypothetical protein NP_838560.1 3163418 R 198215 CDS NP_838561.1 30064390 1077767 3164349..3165122 1 NC_004741.1 residues 1 to 257 of 257 are 88.71 pct identical to residues 1 to 257 of 257 from Escherichia coli K-12 : B3040; zinc transporter ZupT 3165122 ygiE 1077767 ygiE Shigella flexneri 2a str. 2457T zinc transporter ZupT NP_838561.1 3164349 D 198215 CDS NP_838562.1 30064391 1079534 complement(3165611..3166264) 1 NC_004741.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 3166264 ribB 1079534 ribB Shigella flexneri 2a str. 2457T 3,4-dihydroxy-2-butanone 4-phosphate synthase NP_838562.1 3165611 R 198215 CDS NP_838563.1 30064392 1079535 3166578..3166928 1 NC_004741.1 residues 1 to 116 of 116 are 99.13 pct identical to residues 1 to 116 of 116 from Escherichia coli K-12 : B3042; hypothetical protein 3166928 1079535 S3287 Shigella flexneri 2a str. 2457T hypothetical protein NP_838563.1 3166578 D 198215 CDS NP_838564.2 161486436 1079536 3167184..3167549 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3167549 1079536 S3288 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_838564.2 3167184 D 198215 CDS NP_838565.2 161486435 1079537 3167507..3168358 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfB protein 3168358 1079537 S3289 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfB protein NP_838565.2 3167507 D 198215 CDS NP_838566.1 30064395 1080975 3168409..3168684 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3168684 1080975 S3290 Shigella flexneri 2a str. 2457T IS1 orfA NP_838566.1 3168409 D 198215 CDS NP_838567.1 30064396 1079538 3168603..3169106 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3169106 1079538 S3291 Shigella flexneri 2a str. 2457T IS1 orfB NP_838567.1 3168603 D 198215 CDS NP_838568.1 30064397 1079539 3169116..3169391 1 NC_004741.1 residues 1 to 91 of 91 are 97.80 pct identical to residues 358 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 3169391 1079539 S3292 Shigella flexneri 2a str. 2457T IS4 orf NP_838568.1 3169116 D 198215 CDS NP_838569.1 30064398 1077783 complement(3169778..3169978) 1 NC_004741.1 Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS 3169978 glgS 1077783 glgS Shigella flexneri 2a str. 2457T glycogen synthesis protein GlgS NP_838569.1 3169778 R 198215 CDS NP_838570.1 30064399 1078323 3170300..3170599 1 NC_004741.1 residues 1 to 85 of 99 are 100.00 pct identical to residues 1 to 85 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3170599 1078323 S3295 Shigella flexneri 2a str. 2457T IS1 orfA NP_838570.1 3170300 D 198215 CDS NP_838571.1 30064400 1079582 complement(3173108..3174541) 1 NC_004741.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 3174541 1079582 S3298 Shigella flexneri 2a str. 2457T bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase NP_838571.1 3173108 R 198215 CDS NP_838572.1 30064401 1079543 complement(3174589..3177429) 1 NC_004741.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 3177429 glnE 1079543 glnE Shigella flexneri 2a str. 2457T bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase NP_838572.1 3174589 R 198215 CDS NP_838573.1 30064402 1079544 complement(3177452..3178753) 1 NC_004741.1 residues 1 to 433 of 433 are 93.53 pct identical to residues 1 to 433 of 433 from Escherichia coli K-12 : B3054; hypothetical protein 3178753 ygiF 1079544 ygiF Shigella flexneri 2a str. 2457T hypothetical protein NP_838573.1 3177452 R 198215 CDS NP_838574.1 30064403 1079545 3178995..3179615 1 NC_004741.1 residues 1 to 206 of 206 are 87.37 pct identical to residues 1 to 206 of 206 from Escherichia coli K-12 : B3055; signal transduction protein 3179615 ygiM 1079545 ygiM Shigella flexneri 2a str. 2457T signal transduction protein NP_838574.1 3178995 D 198215 CDS NP_838575.1 30064404 1078289 3179679..3180917 1 NC_004741.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3180917 cca 1078289 cca Shigella flexneri 2a str. 2457T multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase NP_838575.1 3179679 D 198215 CDS NP_838576.1 30064405 1079546 complement(3181079..3181900) 1 NC_004741.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 3181900 uppP 1079546 uppP Shigella flexneri 2a str. 2457T undecaprenyl pyrophosphate phosphatase NP_838576.1 3181079 R 198215 CDS NP_838577.1 30064406 1076577 complement(3181991..3182359) 1 NC_004741.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 3182359 folB 1076577 folB Shigella flexneri 2a str. 2457T bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase NP_838577.1 3181991 R 198215 CDS NP_838578.1 30064407 1079547 3182464..3183081 1 NC_004741.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 3183081 ygiH 1079547 ygiH Shigella flexneri 2a str. 2457T glycerol-3-phosphate acyltransferase PlsY NP_838578.1 3182464 D 198215 CDS NP_838579.1 30064408 1078105 complement(3183024..3184025) 1 NC_004741.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR 3184025 ygiP 1078105 ygiP Shigella flexneri 2a str. 2457T transcriptional activator TtdR NP_838579.1 3183024 R 198215 CDS NP_838580.1 30064409 1079550 3184235..3185044 1 NC_004741.1 Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3185044 ttdA 1079550 ttdA Shigella flexneri 2a str. 2457T tartrate dehydratase subunit alpha NP_838580.1 3184235 D 198215 CDS NP_838581.1 30064410 1079551 3185072..3185677 1 NC_004741.1 Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3185677 ttdB 1079551 ttdB Shigella flexneri 2a str. 2457T L(+)-tartrate dehydratase subunit beta NP_838581.1 3185072 D 198215 CDS NP_838582.1 30064411 1079552 3185725..3187188 1 NC_004741.1 residues 1 to 487 of 487 are 82.95 pct identical to residues 1 to 487 of 487 from Escherichia coli K-12 : B3063; hypothetical protein 3187188 ygjE 1079552 ygjE Shigella flexneri 2a str. 2457T hypothetical protein NP_838582.1 3185725 D 198215 CDS NP_838583.1 30064412 1079554 complement(3187231..3188244) 1 NC_004741.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 3188244 ygjD 1079554 ygjD Shigella flexneri 2a str. 2457T DNA-binding/iron metalloprotein/AP endonuclease NP_838583.1 3187231 R 198215 CDS NP_838584.1 30064413 1079555 3188482..3188697 1 NC_004741.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3188697 rpsU 1079555 rpsU Shigella flexneri 2a str. 2457T 30S ribosomal protein S21 NP_838584.1 3188482 D 198215 CDS NP_838585.1 30064414 1079556 3188808..3190553 1 NC_004741.1 synthesizes RNA primers at the replication forks; DNA primase 3190553 dnaG 1079556 dnaG Shigella flexneri 2a str. 2457T DNA primase NP_838585.1 3188808 D 198215 CDS NP_838586.1 30064415 1079047 3190748..3192574 1 NC_004741.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3192574 rpoD 1079047 rpoD Shigella flexneri 2a str. 2457T RNA polymerase sigma factor RpoD NP_838586.1 3190748 D 198215 CDS NP_838587.1 30064416 1079638 3192746..3194074 1 NC_004741.1 residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 3194074 1079638 S3314 Shigella flexneri 2a str. 2457T IS4 orf NP_838587.1 3192746 D 198215 CDS NP_838588.1 30064417 1079560 3195888..3196511 1 NC_004741.1 residues 1 to 207 of 207 are 83.09 pct identical to residues 1 to 207 of 207 from Escherichia coli K-12 : B3071; hypothetical protein 3196511 yqjI 1079560 yqjI Shigella flexneri 2a str. 2457T hypothetical protein NP_838588.1 3195888 D 198215 CDS NP_838589.2 161486434 1077735 3198576..3199982 1 NC_004741.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3199982 ygjG 1077735 ygjG Shigella flexneri 2a str. 2457T putrescine--2-oxoglutarate aminotransferase NP_838589.2 3198576 D 198215 CDS NP_838590.1 30064419 1079563 3200573..3201556 1 NC_004741.1 residues 1 to 327 of 327 are 99.38 pct identical to residues 1 to 327 of 327 from Escherichia coli K-12 : B3075; DNA-binding transcriptional repressor EbgR 3201556 ebgR 1079563 ebgR Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor EbgR NP_838590.1 3200573 D 198215 CDS NP_838591.1 30064420 1079564 3201739..3204825 1 NC_004741.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3204825 ebgA 1079564 ebgA Shigella flexneri 2a str. 2457T cryptic beta-D-galactosidase subunit alpha NP_838591.1 3201739 D 198215 CDS NP_838592.1 30064421 1079565 3204822..3205271 1 NC_004741.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3205271 ebgC 1079565 ebgC Shigella flexneri 2a str. 2457T cryptic beta-D-galactosidase subunit beta NP_838592.1 3204822 D 198215 CDS NP_838593.1 30064422 1079566 3205334..3206767 1 NC_004741.1 residues 1 to 477 of 477 are 92.03 pct identical to residues 1 to 477 of 477 from Escherichia coli K-12 : B3078; oxidoreductase 3206767 ygjI 1079566 ygjI Shigella flexneri 2a str. 2457T oxidoreductase NP_838593.1 3205334 D 198215 CDS NP_838594.1 30064423 1079567 3207989..3210340 1 NC_004741.1 residues 1 to 783 of 783 are 95.65 pct identical to residues 1 to 783 of 783 from Escherichia coli K-12 : B3080; glycosyl hydrolase 3210340 ygjK 1079567 ygjK Shigella flexneri 2a str. 2457T glycosyl hydrolase NP_838594.1 3207989 D 198215 CDS NP_838595.1 30064424 1079568 3210566..3212584 1 NC_004741.1 residues 1 to 672 of 672 are 95.23 pct identical to residues 1 to 672 of 672 from Escherichia coli K-12 : B3081; NADPH dehydrogenase 3212584 ygjL 1079568 ygjL Shigella flexneri 2a str. 2457T NADPH dehydrogenase NP_838595.1 3210566 D 198215 CDS NP_838596.1 30064425 1077095 complement(3212629..3213045) 1 NC_004741.1 residues 1 to 138 of 138 are 90.57 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 : B3082; hypothetical protein 3213045 ygjM 1077095 ygjM Shigella flexneri 2a str. 2457T hypothetical protein NP_838596.1 3212629 R 198215 CDS NP_838597.1 30064426 1079569 complement(3213042..3213356) 1 NC_004741.1 residues 1 to 104 of 104 are 100.00 pct identical to residues 1 to 104 of 104 from Escherichia coli K-12 : B3083; hypothetical protein 3213356 ygjN 1079569 ygjN Shigella flexneri 2a str. 2457T hypothetical protein NP_838597.1 3213042 R 198215 CDS NP_838598.1 30064427 1078756 complement(3213641..3214777) 1 NC_004741.1 residues 1 to 378 of 378 are 95.76 pct identical to residues 11 to 388 of 388 from Escherichia coli K-12 : B3084; enzyme 3214777 ygjO 1078756 ygjO Shigella flexneri 2a str. 2457T enzyme NP_838598.1 3213641 R 198215 CDS NP_838599.1 30064428 1079570 3214826..3215365 1 NC_004741.1 residues 1 to 179 of 179 are 98.32 pct identical to residues 1 to 179 of 179 from Escherichia coli K-12 : B3085; hypothetical protein 3215365 ygjP 1079570 ygjP Shigella flexneri 2a str. 2457T hypothetical protein NP_838599.1 3214826 D 198215 CDS NP_838600.1 30064429 1079571 3215442..3216134 1 NC_004741.1 residues 1 to 230 of 230 are 97.82 pct identical to residues 1 to 230 of 230 from Escherichia coli K-12 : B3086; hypothetical protein 3216134 ygjQ 1079571 ygjQ Shigella flexneri 2a str. 2457T hypothetical protein NP_838600.1 3215442 D 198215 CDS NP_838601.1 30064430 1079572 3216195..3217211 1 NC_004741.1 residues 1 to 334 of 338 are 98.80 pct identical to residues 1 to 334 of 334 from Escherichia coli K-12 : B3087; hypothetical protein 3217211 ygjR 1079572 ygjR Shigella flexneri 2a str. 2457T hypothetical protein NP_838601.1 3216195 D 198215 CDS NP_838602.1 30064431 1079573 3217482..3218447 1 NC_004741.1 residues 1 to 320 of 321 are 97.52 pct identical to residues 1 to 320 of 321 from Escherichia coli K-12 : B3088; transporter 3218447 ygjT 1079573 ygjT Shigella flexneri 2a str. 2457T transporter NP_838602.1 3217482 D 198215 CDS NP_838603.1 30064432 1079574 3219032..3220276 1 NC_004741.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3220276 ygjU 1079574 ygjU Shigella flexneri 2a str. 2457T serine/threonine transporter SstT NP_838603.1 3219032 D 198215 CDS NP_838604.1 30064433 1079575 complement(3220281..3220832) 1 NC_004741.1 residues 1 to 183 of 183 are 98.36 pct identical to residues 1 to 183 of 183 from Escherichia coli K-12 : B3090; hypothetical protein 3220832 ygjV 1079575 ygjV Shigella flexneri 2a str. 2457T hypothetical protein NP_838604.1 3220281 R 198215 CDS NP_838605.1 30064434 1079576 complement(3220915..3222402) 1 NC_004741.1 residues 1 to 495 of 495 are 96.76 pct identical to residues 1 to 495 of 495 from Escherichia coli K-12 : B3091; altronate hydrolase 3222402 uxaA 1079576 uxaA Shigella flexneri 2a str. 2457T altronate hydrolase NP_838605.1 3220915 R 198215 CDS NP_838606.1 30064435 1079577 complement(3222417..3223829) 1 NC_004741.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 3223829 uxaC 1079577 uxaC Shigella flexneri 2a str. 2457T glucuronate isomerase NP_838606.1 3222417 R 198215 CDS NP_838607.1 30064436 1079578 3224314..3225612 1 NC_004741.1 residues 1 to 432 of 432 are 89.58 pct identical to residues 41 to 472 of 472 from Escherichia coli K-12 : B3093; transport protein of hexuronates 3225612 exuT 1079578 exuT Shigella flexneri 2a str. 2457T transport protein of hexuronates NP_838607.1 3224314 D 198215 CDS NP_838608.1 30064437 1079580 complement(3225700..3226332) 1 NC_004741.1 residues 1 to 200 of 210 are 33.81 pct identical to residues 161 to 350 of 359 from GenPept : >emb|CAD08773.1| (AL627266) fimbrail protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 3226332 1079580 S3341 Shigella flexneri 2a str. 2457T hypothetical protein NP_838608.1 3225700 R 198215 CDS NP_838609.1 30064438 1079581 complement(3226785..3228776) 1 NC_004741.1 residues 1 to 645 of 663 are 31.39 pct identical to residues 237 to 878 of 895 from GenPept : >emb|CAD08772.1| (AL627266) outer membrane fimbrial user protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 3228776 1079581 S3342 Shigella flexneri 2a str. 2457T hypothetical protein NP_838609.1 3226785 R 198215 CDS NP_838610.1 30064439 1079583 3228942..3229217 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3229217 1079583 S3343 Shigella flexneri 2a str. 2457T IS1 orfA NP_838610.1 3228942 D 198215 CDS NP_838611.1 30064440 1079584 3229136..3229639 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3229639 1079584 S3344 Shigella flexneri 2a str. 2457T IS1 orfB NP_838611.1 3229136 D 198215 CDS NP_838612.1 30064441 1079595 3229747..3230523 1 NC_004741.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3230523 exuR 1079595 exuR Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor ExuR NP_838612.1 3229747 D 198215 CDS NP_838613.1 30064442 1079585 3230868..3231530 1 NC_004741.1 residues 15 to 220 of 220 are 100.00 pct identical to residues 15 to 220 of 220 from Escherichia coli K-12 : B3095; hypothetical protein 3231530 yqjA 1079585 yqjA Shigella flexneri 2a str. 2457T hypothetical protein NP_838613.1 3230868 D 198215 CDS NP_838614.1 30064443 1079586 3231549..3231917 1 NC_004741.1 residues 1 to 122 of 122 are 85.24 pct identical to residues 6 to 127 of 127 from Escherichia coli K-12 : B3096; hypothetical protein 3231917 yqjB 1079586 yqjB Shigella flexneri 2a str. 2457T hypothetical protein NP_838614.1 3231549 D 198215 CDS NP_838615.1 30064444 1079588 3232456..3232761 1 NC_004741.1 residues 1 to 82 of 101 are 78.04 pct identical to residues 1 to 82 of 101 from Escherichia coli K-12 : B3098; hypothetical protein 3232761 yqjD 1079588 yqjD Shigella flexneri 2a str. 2457T hypothetical protein NP_838615.1 3232456 D 198215 CDS NP_838616.1 30064445 1079589 3232764..3233168 1 NC_004741.1 residues 1 to 134 of 134 are 67.16 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B3099; hypothetical protein 3233168 yqjE 1079589 yqjE Shigella flexneri 2a str. 2457T hypothetical protein NP_838616.1 3232764 D 198215 CDS NP_838617.1 30064446 1079590 3233158..3233457 1 NC_004741.1 residues 1 to 99 of 99 are 95.95 pct identical to residues 1 to 99 of 99 from Escherichia coli K-12 : B3100; hypothetical protein 3233457 1079590 S3351 Shigella flexneri 2a str. 2457T hypothetical protein NP_838617.1 3233158 D 198215 CDS NP_838618.1 30064447 1079592 3234009..3234995 1 NC_004741.1 residues 1 to 328 of 328 are 95.42 pct identical to residues 1 to 328 of 328 from Escherichia coli K-12 : B3102; transferase 3234995 yqjG 1079592 yqjG Shigella flexneri 2a str. 2457T transferase NP_838618.1 3234009 D 198215 CDS NP_838619.1 30064448 1079593 3235288..3235656 1 NC_004741.1 residues 1 to 120 of 122 are 99.16 pct identical to residues 1 to 120 of 121 from Escherichia coli K-12 : B3103; cytochrome 3235656 yhaH 1079593 yhaH Shigella flexneri 2a str. 2457T cytochrome NP_838619.1 3235288 D 198215 CDS NP_838620.1 30064449 1079594 complement(3235863..3236759) 1 NC_004741.1 residues 1 to 298 of 298 are 99.66 pct identical to residues 1 to 298 of 298 from Escherichia coli K-12 : B3105; LYSR-type transcriptional regulator 3236759 yhaJ 1079594 yhaJ Shigella flexneri 2a str. 2457T LYSR-type transcriptional regulator NP_838620.1 3235863 R 198215 CDS NP_838621.1 30064450 1079629 3236864..3237565 1 NC_004741.1 residues 1 to 233 of 233 are 99.14 pct identical to residues 1 to 233 of 233 from Escherichia coli K-12 : B3106; hypothetical protein 3237565 yhaK 1079629 yhaK Shigella flexneri 2a str. 2457T hypothetical protein NP_838621.1 3236864 D 198215 CDS NP_838622.1 30064451 1079596 3237588..3237752 1 NC_004741.1 residues 1 to 54 of 54 are 94.44 pct identical to residues 3 to 56 of 56 from Escherichia coli K-12 : B3107; hypothetical protein 3237752 yhaL 1079596 yhaL Shigella flexneri 2a str. 2457T hypothetical protein NP_838622.1 3237588 D 198215 CDS NP_838623.1 30064452 1079597 complement(3237964..3238530) 1 NC_004741.1 residues 1 to 188 of 188 are 92.02 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 : B3108; hypothetical protein 3238530 yhaM 1079597 yhaM Shigella flexneri 2a str. 2457T hypothetical protein NP_838623.1 3237964 R 198215 CDS NP_838624.1 30064453 1079598 complement(3238466..3239275) 1 NC_004741.1 residues 1 to 184 of 269 are 73.36 pct identical to residues 1 to 184 of 187 from Escherichia coli K-12 : B3109; hypothetical protein 3239275 yhaN 1079598 yhaN Shigella flexneri 2a str. 2457T hypothetical protein NP_838624.1 3238466 R 198215 CDS NP_838625.1 30064454 1079599 complement(3239303..3240634) 1 NC_004741.1 residues 21 to 443 of 443 are 96.69 pct identical to residues 3 to 425 of 425 from Escherichia coli K-12 : B3110; transport system permease 3240634 yhaO 1079599 yhaO Shigella flexneri 2a str. 2457T transport system permease NP_838625.1 3239303 R 198215 CDS NP_838626.1 30064455 1079600 complement(3240909..3242273) 1 NC_004741.1 residues 1 to 453 of 454 are 71.74 pct identical to residues 1 to 453 of 454 from Escherichia coli K-12 : B1814; L-serine deaminase 3242273 1079600 S3363 Shigella flexneri 2a str. 2457T L-serine deaminase NP_838626.1 3240909 R 198215 CDS NP_838627.1 30064456 1079601 complement(3242345..3242734) 1 NC_004741.1 residues 1 to 129 of 129 are 100.00 pct identical to residues 22 to 150 of 150 from Escherichia coli K-12 : B3113; hypothetical protein 3242734 yhaR 1079601 yhaR Shigella flexneri 2a str. 2457T hypothetical protein NP_838627.1 3242345 R 198215 CDS NP_838628.1 30064457 1079602 complement(3242748..3245042) 1 NC_004741.1 residues 1 to 741 of 764 are 97.97 pct identical to residues 1 to 741 of 746 from Escherichia coli K-12 : B3114; formate acetyltransferase 3 3245042 tdcE 1079602 tdcE Shigella flexneri 2a str. 2457T formate acetyltransferase 3 NP_838628.1 3242748 R 198215 CDS NP_838629.2 161486433 1079603 complement(3245076..3246296) 1 NC_004741.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3246296 tdcD 1079603 tdcD Shigella flexneri 2a str. 2457T propionate/acetate kinase NP_838629.2 3245076 R 198215 CDS NP_838630.1 30064459 1079604 complement(3246310..3247641) 1 NC_004741.1 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 3247641 tdcC 1079604 tdcC Shigella flexneri 2a str. 2457T threonine/serine transporter TdcC NP_838630.1 3246310 R 198215 CDS NP_838631.1 30064460 1079605 complement(3247663..3248652) 1 NC_004741.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 3248652 tdcB 1079605 tdcB Shigella flexneri 2a str. 2457T threonine dehydratase NP_838631.1 3247663 R 198215 CDS NP_838632.1 30064461 1079606 complement(3248751..3249689) 1 NC_004741.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA 3249689 tdcA 1079606 tdcA Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator TdcA NP_838632.1 3248751 R 198215 CDS NP_838633.1 30064462 1079607 3249879..3250223 1 NC_004741.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3250223 tdcR 1079607 tdcR Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator TdcR NP_838633.1 3249879 D 198215 CDS NP_838634.1 30064463 1079610 3252275..3252439 1 NC_004741.1 residues 1 to 54 of 54 are 96.29 pct identical to residues 1 to 54 of 54 from Escherichia coli K-12 : B3122; hypothetical protein 3252439 1079610 S3374 Shigella flexneri 2a str. 2457T hypothetical protein NP_838634.1 3252275 D 198215 CDS NP_838635.2 161486432 1079613 complement(3253237..3254382) 1 NC_004741.1 residues 1 to 408 of 408 are 94.60 pct identical to residues 1 to 408 of 408 from Escherichia coli K-12 : B3124; glycerate kinase 3254382 yhaD 1079613 yhaD Shigella flexneri 2a str. 2457T glycerate kinase NP_838635.2 3253237 R 198215 CDS NP_838636.2 161486431 1079614 complement(3254479..3255369) 1 NC_004741.1 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 3255369 garR 1079614 garR Shigella flexneri 2a str. 2457T tartronate semialdehyde reductase NP_838636.2 3254479 R 198215 CDS NP_838637.1 30064466 1079616 complement(3256185..3257519) 1 NC_004741.1 residues 1 to 444 of 444 are 95.94 pct identical to residues 1 to 444 of 444 from Escherichia coli K-12 : B3127; transporter 3257519 yhaU 1079616 yhaU Shigella flexneri 2a str. 2457T transporter NP_838637.1 3256185 R 198215 CDS NP_838638.1 30064467 1079617 3257894..3259465 1 NC_004741.1 residues 1 to 523 of 523 are 94.26 pct identical to residues 1 to 523 of 523 from Escherichia coli K-12 : B3128; hydrolase 3259465 yhaG 1079617 yhaG Shigella flexneri 2a str. 2457T hydrolase NP_838638.1 3257894 D 198215 CDS NP_838639.1 30064468 1079618 complement(3259517..3260341) 1 NC_004741.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR 3260341 agaR 1079618 agaR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator AgaR NP_838639.1 3259517 R 198215 CDS NP_838640.1 30064469 1079619 3260590..3261870 1 NC_004741.1 residues 1 to 426 of 426 are 99.29 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 : B3132; tagatose 6-phosphate kinase 2 3261870 agaZ 1079619 agaZ Shigella flexneri 2a str. 2457T tagatose 6-phosphate kinase 2 NP_838640.1 3260590 D 198215 CDS NP_838641.1 30064470 1079620 3261857..3262366 1 NC_004741.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; N-acetylgalactosamine-specific PTS system transporter subunit IIB 3262366 agaV 1079620 agaV Shigella flexneri 2a str. 2457T N-acetylgalactosamine-specific PTS system transporter subunit IIB NP_838641.1 3261857 D 198215 CDS NP_838642.1 30064471 1079621 3262377..3263156 1 NC_004741.1 residues 1 to 125 of 259 are 65.60 pct identical to residues 1 to 125 of 133 from Escherichia coli K-12 : B3134; PTS transport; N-acetylgalactosameine-specific IIC component 2 3263156 agaW 1079621 agaW Shigella flexneri 2a str. 2457T N-acetylgalactosameine-specific IIC component 2 NP_838642.1 3262377 D 198215 CDS NP_838643.1 30064472 1079622 3263146..3263955 1 NC_004741.1 residues 1 to 269 of 269 are 99.25 pct identical to residues 1 to 269 of 292 from GenPept : >gb|AAG58265.1|AE005542_7 (AE005542) phosphotransferase system enzyme subunit [Escherichia coli O157:H7 EDL933]; PTS transport; transport enzyme subunit 3263955 agaE 1079622 agaE Shigella flexneri 2a str. 2457T transport enzyme subunit NP_838643.1 3263146 D 198215 CDS NP_838644.1 30064473 1079623 3264042..3264476 1 NC_004741.1 residues 1 to 144 of 144 are 98.61 pct identical to residues 1 to 144 of 144 from GenPept : >gb|AAG58266.1|AE005542_8 (AE005542) phosphotransferase system enzyme subunit [Escherichia coli O157:H7 EDL933]; PTS transport; transport enzyme subunit 3264476 agaF 1079623 agaF Shigella flexneri 2a str. 2457T transport enzyme subunit NP_838644.1 3264042 D 198215 CDS NP_838645.1 30064474 1079624 3264473..3264916 1 NC_004741.1 residues 1 to 139 of 147 are 96.40 pct identical to residues 8 to 146 of 384 from GenPept : >gb|AAF81087.1|AF228498_7 (AF228498) AgaA [Escherichia coli]; N-acetylglucosamine-6-phosphate deacetylase 3264916 agaA 1079624 agaA Shigella flexneri 2a str. 2457T N-acetylglucosamine-6-phosphate deacetylase NP_838645.1 3264473 D 198215 CDS NP_838646.1 30064475 1079625 3264945..3265220 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3265220 1079625 S3388 Shigella flexneri 2a str. 2457T IS1 orfA NP_838646.1 3264945 D 198215 CDS NP_838647.1 30064476 1079626 3265139..3265642 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 3265642 1079626 S3389 Shigella flexneri 2a str. 2457T IS1 orfB NP_838647.1 3265139 D 198215 CDS NP_838648.1 30064477 1079627 3265897..3266700 1 NC_004741.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; N-acetylgalactosamine-specific PTS system transporter subunit IIC 3266700 agaC 1079627 agaC Shigella flexneri 2a str. 2457T N-acetylgalactosamine-specific PTS system transporter subunit IIC NP_838648.1 3265897 D 198215 CDS NP_838649.1 30064478 1079630 3266690..3267481 1 NC_004741.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; N-acetylgalactosamine-specific PTS system transporter subunit IID 3267481 agaD 1079630 agaD Shigella flexneri 2a str. 2457T N-acetylgalactosamine-specific PTS system transporter subunit IID NP_838649.1 3266690 D 198215 CDS NP_838650.1 30064479 1079631 3267482..3268237 1 NC_004741.1 residues 1 to 251 of 251 are 93.62 pct identical to residues 1 to 251 of 251 from Escherichia coli K-12 : B3141; galactosamine-6-phosphate isomerase 3268237 agaI 1079631 agaI Shigella flexneri 2a str. 2457T galactosamine-6-phosphate isomerase NP_838650.1 3267482 D 198215 CDS NP_838651.1 30064480 1079632 complement(3268746..3269249) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 ORF2 3269249 1079632 S3394 Shigella flexneri 2a str. 2457T IS1 ORF2 NP_838651.1 3268746 R 198215 CDS NP_838652.1 30064481 1079633 complement(3269168..3269443) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3269443 1079633 S3395 Shigella flexneri 2a str. 2457T IS1 orfA NP_838652.1 3269168 R 198215 CDS NP_838653.1 30064482 1079634 3270079..3270774 1 NC_004741.1 residues 1 to 231 of 231 are 99.13 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 : B3143; chaperone 3270774 yraI 1079634 yraI Shigella flexneri 2a str. 2457T chaperone NP_838653.1 3270079 D 198215 CDS NP_838654.1 30064483 1079636 complement(3272539..3272961) 1 NC_004741.1 residues 1 to 140 of 140 are 98.57 pct identical to residues 162 to 301 of 301 from GenPept : >gb|AAD10297.1| (U82084) unknown [bacteriophage SfX]; partial; IS2 orfB 3272961 1079636 S3399 Shigella flexneri 2a str. 2457T IS2 orfB NP_838654.1 3272539 R 198215 CDS NP_838655.2 161486430 1078008 complement(3273400..3273765) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3273765 1078008 S3401 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_838655.2 3273400 R 198215 CDS NP_838656.1 30064485 1079637 3274664..3275755 1 NC_004741.1 residues 1 to 363 of 363 are 95.31 pct identical to residues 1 to 363 of 363 from Escherichia coli K-12 : B3145; fimbrial protein 3275755 yraK 1079637 yraK Shigella flexneri 2a str. 2457T fimbrial protein NP_838656.1 3274664 D 198215 CDS NP_838657.1 30064486 1079639 complement(3275798..3276658) 1 NC_004741.1 residues 1 to 286 of 286 are 91.95 pct identical to residues 1 to 286 of 286 from Escherichia coli K-12 : B3146; hypothetical protein 3276658 yraL 1079639 yraL Shigella flexneri 2a str. 2457T hypothetical protein NP_838657.1 3275798 R 198215 CDS NP_838658.1 30064487 1079641 3276723..3278759 1 NC_004741.1 residues 1 to 678 of 678 are 88.93 pct identical to residues 1 to 678 of 678 from Escherichia coli K-12 : B3147; glycosylase 3278759 yraM 1079641 yraM Shigella flexneri 2a str. 2457T glycosylase NP_838658.1 3276723 D 198215 CDS NP_838659.1 30064488 1079643 3278717..3279112 1 NC_004741.1 residues 1 to 131 of 131 are 98.47 pct identical to residues 1 to 131 of 131 from Escherichia coli K-12 : B3148; hypothetical protein 3279112 yraN 1079643 yraN Shigella flexneri 2a str. 2457T hypothetical protein NP_838659.1 3278717 D 198215 CDS NP_838660.1 30064489 1077991 3279132..3279722 1 NC_004741.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3279722 yraO 1077991 yraO Shigella flexneri 2a str. 2457T DnaA initiator-associating protein DiaA NP_838660.1 3279132 D 198215 CDS NP_838661.1 30064490 1079645 3279732..3280307 1 NC_004741.1 residues 1 to 191 of 191 are 90.57 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B3150; hypothetical protein 3280307 yraP 1079645 yraP Shigella flexneri 2a str. 2457T hypothetical protein NP_838661.1 3279732 D 198215 CDS NP_838662.1 30064491 1079646 complement(3280421..3281461) 1 NC_004741.1 residues 1 to 346 of 346 are 93.64 pct identical to residues 1 to 346 of 346 from Escherichia coli K-12 : B3151; hypothetical protein 3281461 yraQ 1079646 yraQ Shigella flexneri 2a str. 2457T hypothetical protein NP_838662.1 3280421 R 198215 CDS NP_838663.1 30064492 1079647 complement(3281534..3282214) 1 NC_004741.1 residues 1 to 226 of 226 are 98.67 pct identical to residues 1 to 226 of 226 from Escherichia coli K-12 : B3152; hypothetical protein 3282214 yraR 1079647 yraR Shigella flexneri 2a str. 2457T hypothetical protein NP_838663.1 3281534 R 198215 CDS NP_838664.1 30064493 1079649 3282255..3282815 1 NC_004741.1 residues 1 to 186 of 186 are 98.92 pct identical to residues 1 to 186 of 186 from Escherichia coli K-12 : B3153; hypothetical protein 3282815 yhbO 1079649 yhbO Shigella flexneri 2a str. 2457T hypothetical protein NP_838664.1 3282255 D 198215 CDS NP_838665.1 30064494 1079650 complement(3282795..3283238) 1 NC_004741.1 residues 1 to 147 of 147 are 100.00 pct identical to residues 1 to 147 of 147 from Escherichia coli K-12 : B3154; hypothetical protein 3283238 yhbP 1079650 yhbP Shigella flexneri 2a str. 2457T hypothetical protein NP_838665.1 3282795 R 198215 CDS NP_838666.1 30064495 1078053 3283289..3283591 1 NC_004741.1 residues 1 to 100 of 100 are 99.00 pct identical to residues 1 to 100 of 100 from Escherichia coli K-12 : B3155; GIY-YIG nuclease superfamily protein 3283591 yhbQ 1078053 yhbQ Shigella flexneri 2a str. 2457T GIY-YIG nuclease superfamily protein NP_838666.1 3283289 D 198215 CDS NP_838667.1 30064496 1079652 complement(3283578..3284081) 1 NC_004741.1 residues 1 to 167 of 167 are 99.40 pct identical to residues 1 to 167 of 167 from Escherichia coli K-12 : B3156; hypothetical protein 3284081 yhbS 1079652 yhbS Shigella flexneri 2a str. 2457T hypothetical protein NP_838667.1 3283578 R 198215 CDS NP_838668.1 30064497 1079653 complement(3284075..3284599) 1 NC_004741.1 residues 1 to 174 of 174 are 98.85 pct identical to residues 1 to 174 of 174 from Escherichia coli K-12 : B3157; hypothetical protein 3284599 yhbT 1079653 yhbT Shigella flexneri 2a str. 2457T hypothetical protein NP_838668.1 3284075 R 198215 CDS NP_838669.1 30064498 1078610 3284808..3285803 1 NC_004741.1 residues 1 to 331 of 331 are 94.25 pct identical to residues 1 to 331 of 331 from Escherichia coli K-12 : B3158; collagenase 3285803 yhbU 1078610 yhbU Shigella flexneri 2a str. 2457T collagenase NP_838669.1 3284808 D 198215 CDS NP_838670.1 30064499 1079654 3285812..3286690 1 NC_004741.1 residues 1 to 292 of 292 are 98.63 pct identical to residues 7 to 298 of 298 from Escherichia coli K-12 : B3159; hypothetical protein 3286690 yhbV 1079654 yhbV Shigella flexneri 2a str. 2457T hypothetical protein NP_838670.1 3285812 D 198215 CDS NP_838671.1 30064500 1079902 3286771..3287778 1 NC_004741.1 residues 1 to 335 of 335 are 99.40 pct identical to residues 1 to 335 of 335 from Escherichia coli K-12 : B3160; hypothetical protein 3287778 yhbW 1079902 yhbW Shigella flexneri 2a str. 2457T hypothetical protein NP_838671.1 3286771 D 198215 CDS NP_838672.1 30064501 1079656 complement(3287896..3289140) 1 NC_004741.1 tryptophan transporter of high affinity; tryptophan permease 3289140 mtr 1079656 mtr Shigella flexneri 2a str. 2457T tryptophan permease NP_838672.1 3287896 R 198215 CDS NP_838673.2 161486429 1078673 complement(3289294..3291183) 1 NC_004741.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 3291183 deaD 1078673 deaD Shigella flexneri 2a str. 2457T ATP-dependent RNA helicase DeaD NP_838673.2 3289294 R 198215 CDS NP_838674.1 30064503 1079657 complement(3291363..3292247) 1 NC_004741.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 3292247 yhbM 1079657 yhbM Shigella flexneri 2a str. 2457T lipoprotein NlpI NP_838674.1 3291363 R 198215 CDS NP_838675.1 30064504 1079659 complement(3292356..3294560) 1 NC_004741.1 residues 1 to 713 of 734 are 93.54 pct identical to residues 1 to 713 of 734 from Escherichia coli K-12 : B3164; cytidylate kinase activity; polynucleotide phosphorylase/polyadenylase 3294560 pnp 1079659 pnp Shigella flexneri 2a str. 2457T polynucleotide phosphorylase/polyadenylase NP_838675.1 3292356 R 198215 CDS NP_838676.1 30064505 1079660 complement(3294738..3295007) 1 NC_004741.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3295007 rpsO 1079660 rpsO Shigella flexneri 2a str. 2457T 30S ribosomal protein S15 NP_838676.1 3294738 R 198215 CDS NP_838677.1 30064506 1079661 complement(3295156..3296100) 1 NC_004741.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3296100 truB 1079661 truB Shigella flexneri 2a str. 2457T tRNA pseudouridine synthase B NP_838677.1 3295156 R 198215 CDS NP_838678.1 30064507 1079662 complement(3296100..3296501) 1 NC_004741.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3296501 rbfA 1079662 rbfA Shigella flexneri 2a str. 2457T ribosome-binding factor A NP_838678.1 3296100 R 198215 CDS NP_838679.1 30064508 1079663 complement(3296665..3299313) 1 NC_004741.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3299313 infB 1079663 infB Shigella flexneri 2a str. 2457T translation initiation factor IF-2 NP_838679.1 3296665 R 198215 CDS NP_838680.1 30064509 1078149 complement(3299338..3300825) 1 NC_004741.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3300825 nusA 1078149 nusA Shigella flexneri 2a str. 2457T transcription elongation factor NusA NP_838680.1 3299338 R 198215 CDS NP_838681.2 161486428 1079664 complement(3300853..3301305) 1 NC_004741.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3301305 yhbC 1079664 yhbC Shigella flexneri 2a str. 2457T hypothetical protein NP_838681.2 3300853 R 198215 CDS NP_838682.1 30064511 1079667 3301936..3303279 1 NC_004741.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3303279 argG 1079667 argG Shigella flexneri 2a str. 2457T argininosuccinate synthase NP_838682.1 3301936 D 198215 CDS NP_838683.1 30064512 1078079 complement(3303287..3303769) 1 NC_004741.1 residues 1 to 160 of 160 are 99.37 pct identical to residues 388 to 547 of 547 from Escherichia coli K-12 : B3173; alkaline phosphatase I 3303769 yhbX 1078079 yhbX Shigella flexneri 2a str. 2457T alkaline phosphatase I NP_838683.1 3303287 R 198215 CDS NP_838684.1 30064513 1077635 complement(3305473..3305805) 1 NC_004741.1 residues 1 to 110 of 110 are 99.09 pct identical to residues 1 to 110 of 110 from Escherichia coli K-12 : B3175; preprotein translocase subunit SecG 3305805 secG 1077635 secG Shigella flexneri 2a str. 2457T preprotein translocase subunit SecG NP_838684.1 3305473 R 198215 CDS NP_838685.1 30064514 1079670 complement(3306033..3307370) 1 NC_004741.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3307370 glmM 1079670 glmM Shigella flexneri 2a str. 2457T phosphoglucosamine mutase NP_838685.1 3306033 R 198215 CDS NP_838686.2 161486427 1079671 complement(3307363..3308211) 1 NC_004741.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase 3308211 folP 1079671 folP Shigella flexneri 2a str. 2457T dihydropteroate synthase NP_838686.2 3307363 R 198215 CDS NP_838687.1 30064516 1079672 complement(3308301..3310235) 1 NC_004741.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 3310235 hflB 1079672 hflB Shigella flexneri 2a str. 2457T ATP-dependent metalloprotease NP_838687.1 3308301 R 198215 CDS NP_838688.1 30064517 1079673 complement(3310335..3310964) 1 NC_004741.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J 3310964 rrmJ 1079673 rrmJ Shigella flexneri 2a str. 2457T 23S rRNA methyltransferase J NP_838688.1 3310335 R 198215 CDS NP_838689.1 30064518 1079674 3311090..3311383 1 NC_004741.1 RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3311383 yhbY 1079674 yhbY Shigella flexneri 2a str. 2457T RNA-binding protein YhbY NP_838689.1 3311090 D 198215 CDS NP_838690.1 30064519 1079675 complement(3311539..3312015) 1 NC_004741.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 3312015 greA 1079675 greA Shigella flexneri 2a str. 2457T transcription elongation factor GreA NP_838690.1 3311539 R 198215 CDS NP_838691.1 30064520 1079676 3312263..3313696 1 NC_004741.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 3313696 dacB 1079676 dacB Shigella flexneri 2a str. 2457T D-alanyl-D-alanine carboxypeptidase NP_838691.1 3312263 D 198215 CDS NP_838692.1 30064521 1079677 complement(3313882..3315054) 1 NC_004741.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 3315054 obgE 1079677 obgE Shigella flexneri 2a str. 2457T GTPase ObgE NP_838692.1 3313882 R 198215 CDS NP_838693.1 30064522 1079678 complement(3315070..3316035) 1 NC_004741.1 residues 1 to 321 of 321 are 95.01 pct identical to residues 1 to 321 of 321 from Escherichia coli K-12 : B3184; hypothetical protein 3316035 yhbE 1079678 yhbE Shigella flexneri 2a str. 2457T hypothetical protein NP_838693.1 3315070 R 198215 CDS NP_838694.1 30064523 1079396 complement(3316162..3316419) 1 NC_004741.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 3316419 rpmA 1079396 rpmA Shigella flexneri 2a str. 2457T 50S ribosomal protein L27 NP_838694.1 3316162 R 198215 CDS NP_838695.1 30064524 1079679 complement(3316440..3316751) 1 NC_004741.1 residues 1 to 103 of 103 are 100.00 pct identical to residues 1 to 103 of 103 from Escherichia coli K-12 : B3186; 50S ribosomal protein L21 3316751 rplU 1079679 rplU Shigella flexneri 2a str. 2457T 50S ribosomal protein L21 NP_838695.1 3316440 R 198215 CDS NP_838696.1 30064525 1079548 3317009..3317980 1 NC_004741.1 residues 1 to 323 of 323 are 96.59 pct identical to residues 1 to 323 of 323 from Escherichia coli K-12 : B3187; octaprenyl diphosphate synthase 3317980 ispB 1079548 ispB Shigella flexneri 2a str. 2457T octaprenyl diphosphate synthase NP_838696.1 3317009 D 198215 CDS NP_838697.1 30064526 1079682 3318207..3318485 1 NC_004741.1 activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3318485 nlp 1079682 nlp Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator Nlp NP_838697.1 3318207 D 198215 CDS NP_838698.1 30064527 1079742 complement(3318533..3319792) 1 NC_004741.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 3319792 murA 1079742 murA Shigella flexneri 2a str. 2457T UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_838698.1 3318533 R 198215 CDS NP_838699.1 30064528 1079683 complement(3319847..3320116) 1 NC_004741.1 residues 1 to 89 of 89 are 100.00 pct identical to residues 1 to 89 of 89 from Escherichia coli K-12 : B3190; hypothetical protein 3320116 yrbA 1079683 yrbA Shigella flexneri 2a str. 2457T hypothetical protein NP_838699.1 3319847 R 198215 CDS NP_838700.1 30064529 1079685 complement(3320261..3320650) 1 NC_004741.1 residues 1 to 129 of 129 are 92.24 pct identical to residues 1 to 129 of 129 from Escherichia coli K-12 : B3191; hypothetical protein 3320650 yrbB 1079685 yrbB Shigella flexneri 2a str. 2457T hypothetical protein NP_838700.1 3320261 R 198215 CDS NP_838701.1 30064530 1079404 complement(3320554..3321189) 1 NC_004741.1 residues 1 to 211 of 211 are 100.00 pct identical to residues 1 to 211 of 211 from Escherichia coli K-12 : B3192; hypothetical protein 3321189 yrbC 1079404 yrbC Shigella flexneri 2a str. 2457T hypothetical protein NP_838701.1 3320554 R 198215 CDS NP_838702.1 30064531 1079686 complement(3321208..3321759) 1 NC_004741.1 residues 1 to 183 of 183 are 90.71 pct identical to residues 1 to 183 of 183 from Escherichia coli K-12 : B3193; cytoplasmic membrane protein 3321759 vpsC 1079686 vpsC Shigella flexneri 2a str. 2457T cytoplasmic membrane protein NP_838702.1 3321208 R 198215 CDS NP_838703.1 30064532 1076490 complement(3321764..3322546) 1 NC_004741.1 residues 1 to 260 of 260 are 100.00 pct identical to residues 1 to 260 of 260 from Escherichia coli K-12 : B3194; integral membrane protein 3322546 vpsB 1076490 vpsB Shigella flexneri 2a str. 2457T integral membrane protein NP_838703.1 3321764 R 198215 CDS NP_838704.1 30064533 1079688 complement(3322554..3323363) 1 NC_004741.1 ATP-binding subunit of a ABC toluene efflux transporter; ABC transporter ATP-binding protein 3323363 vpsA 1079688 vpsA Shigella flexneri 2a str. 2457T ABC transporter ATP-binding protein NP_838704.1 3322554 R 198215 CDS NP_838705.1 30064534 1078234 3323573..3324538 1 NC_004741.1 YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 3324538 yrbG 1078234 yrbG Shigella flexneri 2a str. 2457T calcium/sodium:proton antiporter NP_838705.1 3323573 D 198215 CDS NP_838706.1 30064535 1079689 3324552..3325538 1 NC_004741.1 residues 1 to 328 of 328 are 96.34 pct identical to residues 1 to 328 of 328 from Escherichia coli K-12 : B3197; D-arabinose 5-phosphate isomerase 3325538 yrbH 1079689 yrbH Shigella flexneri 2a str. 2457T D-arabinose 5-phosphate isomerase NP_838706.1 3324552 D 198215 CDS NP_838707.1 30064536 1079690 3325559..3326125 1 NC_004741.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3326125 yrbI 1079690 yrbI Shigella flexneri 2a str. 2457T 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase NP_838707.1 3325559 D 198215 CDS NP_838708.1 30064537 1079691 3326122..3326697 1 NC_004741.1 residues 1 to 191 of 191 are 100.00 pct identical to residues 1 to 191 of 191 from Escherichia coli K-12 : B3199; hypothetical protein 3326697 yrbK 1079691 yrbK Shigella flexneri 2a str. 2457T hypothetical protein NP_838708.1 3326122 D 198215 CDS NP_838709.1 30064538 1079692 3326666..3327223 1 NC_004741.1 LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3327223 yhbN 1079692 yhbN Shigella flexneri 2a str. 2457T lipopolysaccharide transport periplasmic protein LptA NP_838709.1 3326666 D 198215 CDS NP_838710.1 30064539 1079693 3327230..3327955 1 NC_004741.1 residues 1 to 241 of 241 are 96.68 pct identical to residues 1 to 241 of 241 from Escherichia coli K-12 : B3201; ABC transporter ATP-binding protein 3327955 yhbG 1079693 yhbG Shigella flexneri 2a str. 2457T ABC transporter ATP-binding protein NP_838710.1 3327230 D 198215 CDS NP_838711.1 30064540 1080356 3328003..3329436 1 NC_004741.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3329436 rpoN 1080356 rpoN Shigella flexneri 2a str. 2457T RNA polymerase factor sigma-54 NP_838711.1 3328003 D 198215 CDS NP_838712.1 30064541 1077882 3329459..3329746 1 NC_004741.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 3329746 yhbH 1077882 yhbH Shigella flexneri 2a str. 2457T sigma(54) modulation protein NP_838712.1 3329459 D 198215 CDS NP_838713.1 30064542 1079694 3329864..3330355 1 NC_004741.1 residues 1 to 163 of 163 are 100.00 pct identical to residues 1 to 163 of 163 from Escherichia coli K-12 : B3204; regulates N metabolism; PTS IIA-like nitrogen-regulatory protein PtsN 3330355 ptsN 1079694 ptsN Shigella flexneri 2a str. 2457T PTS IIA-like nitrogen-regulatory protein PtsN NP_838713.1 3329864 D 198215 CDS NP_838714.1 30064543 1079364 3330401..3331255 1 NC_004741.1 residues 1 to 284 of 284 are 95.77 pct identical to residues 1 to 284 of 284 from Escherichia coli K-12 : B3205; hypothetical protein 3331255 yhbJ 1079364 yhbJ Shigella flexneri 2a str. 2457T hypothetical protein NP_838714.1 3330401 D 198215 CDS NP_838715.1 30064544 1079695 3331252..3331524 1 NC_004741.1 residues 1 to 90 of 90 are 100.00 pct identical to residues 1 to 90 of 90 from Escherichia coli K-12 : B3206; HPr-like, nitrogen related, exchangesphosphate with Enzymei, Hpr; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3331524 ptsO 1079695 ptsO Shigella flexneri 2a str. 2457T phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) NP_838715.1 3331252 D 198215 CDS NP_838716.1 30064545 1079697 3331737..3332369 1 NC_004741.1 residues 1 to 210 of 210 are 93.33 pct identical to residues 1 to 210 of 210 from Escherichia coli K-12 : B3207; hypothetical protein 3332369 yrbL 1079697 yrbL Shigella flexneri 2a str. 2457T hypothetical protein NP_838716.1 3331737 D 198215 CDS NP_838717.1 30064546 1079698 complement(3333090..3333743) 1 NC_004741.1 residues 1 to 217 of 217 are 94.47 pct identical to residues 4 to 220 of 220 from Escherichia coli K-12 : B3209; isoprenoid biosynthesis protein with amidotransferase-like domain 3333743 yhbL 1079698 yhbL Shigella flexneri 2a str. 2457T isoprenoid biosynthesis protein with amidotransferase-like domain NP_838717.1 3333090 R 198215 CDS NP_838718.1 30064547 1078081 complement(3333973..3336309) 1 NC_004741.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 3336309 arcB 1078081 arcB Shigella flexneri 2a str. 2457T aerobic respiration control sensor protein ArcB NP_838718.1 3333973 R 198215 CDS NP_838719.1 30064548 1079699 complement(3336405..3337334) 1 NC_004741.1 residues 1 to 309 of 309 are 99.67 pct identical to residues 1 to 309 of 309 from Escherichia coli K-12 : B3211; hypothetical protein 3337334 yhcC 1079699 yhcC Shigella flexneri 2a str. 2457T hypothetical protein NP_838719.1 3336405 R 198215 CDS NP_838720.2 161486426 1078530 3337916..3342469 1 NC_004741.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase 3342469 gltB 1078530 gltB Shigella flexneri 2a str. 2457T glutamate synthase NP_838720.2 3337916 D 198215 CDS NP_838721.1 30064550 1079700 3342482..3343900 1 NC_004741.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase 3343900 gltD 1079700 gltD Shigella flexneri 2a str. 2457T glutamate synthase NP_838721.1 3342482 D 198215 CDS NP_838722.1 30064551 1079702 3345046..3346116 1 NC_004741.1 residues 1 to 257 of 356 are 86.04 pct identical to residues 36 to 293 of 307 from GenPept : >gb|AAF28144.1|AF153317_45 (AF153317) InsB [Shigella dysenteriae]; IS600 orf 3346116 1079702 S3473 Shigella flexneri 2a str. 2457T IS600 orf NP_838722.1 3345046 D 198215 CDS NP_838723.1 30064552 1079704 complement(3346192..3346656) 1 NC_004741.1 residues 1 to 154 of 154 are 90.25 pct identical to residues 1 to 154 of 154 from Escherichia coli K-12 : B3221; hypothetical protein 3346656 yhcH 1079704 yhcH Shigella flexneri 2a str. 2457T hypothetical protein NP_838723.1 3346192 R 198215 CDS NP_838724.2 161486425 1079665 complement(3346653..3347528) 1 NC_004741.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 3347528 yhcI 1079665 yhcI Shigella flexneri 2a str. 2457T N-acetylmannosamine kinase NP_838724.2 3346653 R 198215 CDS NP_838725.1 30064554 1079706 complement(3347525..3348214) 1 NC_004741.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 3348214 yhcJ 1079706 yhcJ Shigella flexneri 2a str. 2457T N-acetylmannosamine-6-phosphate 2-epimerase NP_838725.1 3347525 R 198215 CDS NP_838726.2 161486424 1076756 complement(3348262..3349752) 1 NC_004741.1 residues 1 to 506 of 506 are 89.72 pct identical to residues 1 to 506 of 506 from Escherichia coli K-12 : B3224; sialic acid transporter 3349752 nanT 1076756 nanT Shigella flexneri 2a str. 2457T sialic acid transporter NP_838726.2 3348262 R 198215 CDS NP_838727.1 30064556 1079707 complement(3349862..3350755) 1 NC_004741.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 3350755 nanA 1079707 nanA Shigella flexneri 2a str. 2457T N-acetylneuraminate lyase NP_838727.1 3349862 R 198215 CDS NP_838728.1 30064557 1079708 complement(3350877..3351659) 1 NC_004741.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 3351659 yhcK 1079708 yhcK Shigella flexneri 2a str. 2457T transcriptional regulator NanR NP_838728.1 3350877 R 198215 CDS NP_838729.1 30064558 1079709 3352106..3352381 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3352381 1079709 S3480 Shigella flexneri 2a str. 2457T IS1 orfA NP_838729.1 3352106 D 198215 CDS NP_838730.1 30064559 1078992 3352300..3352803 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3352803 1078992 S3481 Shigella flexneri 2a str. 2457T IS1 orfB NP_838730.1 3352300 D 198215 CDS NP_838731.1 30064560 1079710 3352824..3354191 1 NC_004741.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; cryptic C4-dicarboxylate transporter DcuD 3354191 yhcL 1079710 yhcL Shigella flexneri 2a str. 2457T cryptic C4-dicarboxylate transporter DcuD NP_838731.1 3352824 D 198215 CDS NP_838732.1 30064561 1079711 complement(3354234..3354731) 1 NC_004741.1 residues 1 to 133 of 165 are 100.00 pct identical to residues 1 to 133 of 165 from Escherichia coli K-12 : B3228; ClpXP protease specificity-enhancing factor 3354731 sspB 1079711 sspB Shigella flexneri 2a str. 2457T ClpXP protease specificity-enhancing factor NP_838732.1 3354234 R 198215 CDS NP_838733.1 30064562 1079712 complement(3354737..3355375) 1 NC_004741.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 3355375 sspA 1079712 sspA Shigella flexneri 2a str. 2457T stringent starvation protein A NP_838733.1 3354737 R 198215 CDS NP_838734.1 30064563 1079713 complement(3355770..3356162) 1 NC_004741.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3356162 rpsI 1079713 rpsI Shigella flexneri 2a str. 2457T 30S ribosomal protein S9 NP_838734.1 3355770 R 198215 CDS NP_838735.1 30064564 1079714 complement(3356178..3356606) 1 NC_004741.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3356606 rplM 1079714 rplM Shigella flexneri 2a str. 2457T 50S ribosomal protein L13 NP_838735.1 3356178 R 198215 CDS NP_838736.1 30064565 1079715 complement(3356825..3357952) 1 NC_004741.1 residues 1 to 375 of 375 are 98.66 pct identical to residues 1 to 375 of 375 from Escherichia coli K-12 : B3232; hypothetical protein 3357952 yhcM 1079715 yhcM Shigella flexneri 2a str. 2457T hypothetical protein NP_838736.1 3356825 R 198215 CDS NP_838737.1 30064566 1079716 3358146..3358544 1 NC_004741.1 residues 1 to 132 of 132 are 78.03 pct identical to residues 3 to 134 of 134 from Escherichia coli K-12 : B3233; cytochrome d ubiquinol oxidase subunit III 3358544 yhcB 1079716 yhcB Shigella flexneri 2a str. 2457T cytochrome d ubiquinol oxidase subunit III NP_838737.1 3358146 D 198215 CDS NP_838738.1 30064567 1079718 3360135..3361202 1 NC_004741.1 residues 1 to 355 of 355 are 89.85 pct identical to residues 1 to 355 of 355 from Escherichia coli K-12 : B3235; serine endoprotease 3361202 degS 1079718 degS Shigella flexneri 2a str. 2457T serine endoprotease NP_838738.1 3360135 D 198215 CDS NP_838739.1 30064568 1079719 complement(3361264..3362202) 1 NC_004741.1 oxidizes malate to oxaloacetate; malate dehydrogenase 3362202 mdh 1079719 mdh Shigella flexneri 2a str. 2457T malate dehydrogenase NP_838739.1 3361264 R 198215 CDS NP_838740.1 30064569 1079720 3362637..3363107 1 NC_004741.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 3363107 argR 1079720 argR Shigella flexneri 2a str. 2457T arginine repressor NP_838740.1 3362637 D 198215 CDS NP_838741.1 30064570 1079721 3363421..3363735 1 NC_004741.1 residues 1 to 104 of 104 are 83.65 pct identical to residues 1 to 104 of 104 from Escherichia coli K-12 : B3238; hypothetical protein 3363735 yhcN 1079721 yhcN Shigella flexneri 2a str. 2457T hypothetical protein NP_838741.1 3363421 D 198215 CDS NP_838742.1 30064571 1079722 complement(3363791..3364063) 1 NC_004741.1 residues 1 to 90 of 90 are 98.88 pct identical to residues 1 to 90 of 90 from Escherichia coli K-12 : B3239; hypothetical protein 3364063 yhcO 1079722 yhcO Shigella flexneri 2a str. 2457T hypothetical protein NP_838742.1 3363791 R 198215 CDS NP_838743.1 30064572 1077875 complement(3364155..3366122) 1 NC_004741.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 3366122 yhcP 1077875 yhcP Shigella flexneri 2a str. 2457T p-hydroxybenzoic acid efflux subunit AaeB NP_838743.1 3364155 R 198215 CDS NP_838744.1 30064573 1079723 complement(3366128..3367060) 1 NC_004741.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA 3367060 yhcQ 1079723 yhcQ Shigella flexneri 2a str. 2457T p-hydroxybenzoic acid efflux subunit AaeA NP_838744.1 3366128 R 198215 CDS NP_838745.2 161486423 1079724 complement(3367068..3367271) 1 NC_004741.1 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 3367271 yhcR 1079724 yhcR Shigella flexneri 2a str. 2457T hypothetical protein NP_838745.2 3367068 R 198215 CDS NP_838746.1 30064575 1079725 3367472..3368383 1 NC_004741.1 residues 1 to 303 of 303 are 99.66 pct identical to residues 7 to 309 of 309 from Escherichia coli K-12 : B3243; DNA-binding transcriptional regulator 3368383 yhcS 1079725 yhcS Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator NP_838746.1 3367472 D 198215 CDS NP_838747.1 30064576 1079726 complement(3368511..3369956) 1 NC_004741.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD 3369956 tldD 1079726 tldD Shigella flexneri 2a str. 2457T protease TldD NP_838747.1 3368511 R 198215 CDS NP_838748.1 30064577 1079727 complement(3370112..3373072) 1 NC_004741.1 residues 1 to 986 of 986 are 99.49 pct identical to residues 1 to 986 of 986 from Escherichia coli K-12 : B3245; hypothetical protein 3373072 yhdP 1079727 yhdP Shigella flexneri 2a str. 2457T hypothetical protein NP_838748.1 3370112 R 198215 CDS NP_838749.1 30064578 1079730 complement(3373980..3375449) 1 NC_004741.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 3375449 cafA 1079730 cafA Shigella flexneri 2a str. 2457T ribonuclease G NP_838749.1 3373980 R 198215 CDS NP_838750.1 30064579 1079731 complement(3375439..3376032) 1 NC_004741.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3376032 maf 1079731 maf Shigella flexneri 2a str. 2457T Maf-like protein NP_838750.1 3375439 R 198215 CDS NP_838751.1 30064580 1079732 complement(3376041..3376529) 1 NC_004741.1 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 3376529 mreD 1079732 mreD Shigella flexneri 2a str. 2457T rod shape-determining protein MreD NP_838751.1 3376041 R 198215 CDS NP_838752.1 30064581 1078482 complement(3376736..3377632) 1 NC_004741.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 3377632 mreC 1078482 mreC Shigella flexneri 2a str. 2457T rod shape-determining protein MreC NP_838752.1 3376736 R 198215 CDS NP_838753.2 229089134 1079734 complement(3377698..3378741) 1 NC_004741.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 3378741 mreB 1079734 mreB Shigella flexneri 2a str. 2457T rod shape-determining protein MreB NP_838753.2 3377698 R 198215 CDS NP_838754.1 30064583 1079735 complement(3379046..3380986) 1 NC_004741.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 3380986 yhdA 1079735 yhdA Shigella flexneri 2a str. 2457T regulatory protein CsrD NP_838754.1 3379046 R 198215 CDS NP_838755.1 30064584 1079736 3381138..3382112 1 NC_004741.1 residues 1 to 324 of 324 are 90.74 pct identical to residues 1 to 324 of 324 from Escherichia coli K-12 : B3253; dehydrogenase 3382112 yhdH 1079736 yhdH Shigella flexneri 2a str. 2457T dehydrogenase NP_838755.1 3381138 D 198215 CDS NP_838756.1 30064585 1079738 complement(3382170..3382271) 1 NC_004741.1 residues 1 to 33 of 33 are 100.00 pct identical to residues 1 to 33 of 33 from Escherichia coli K-12 : B3254; hypothetical protein 3382271 1079738 S3509 Shigella flexneri 2a str. 2457T hypothetical protein NP_838756.1 3382170 R 198215 CDS NP_838757.1 30064586 1080905 3383090..3383560 1 NC_004741.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3383560 accB 1080905 accB Shigella flexneri 2a str. 2457T acetyl-CoA carboxylase biotin carboxyl carrier protein subunit NP_838757.1 3383090 D 198215 CDS NP_838758.1 30064587 1080972 3383571..3384920 1 NC_004741.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3384920 accC 1080972 accC Shigella flexneri 2a str. 2457T acetyl-CoA carboxylase biotin carboxylase subunit NP_838758.1 3383571 D 198215 CDS NP_838759.1 30064588 1079741 3385029..3385271 1 NC_004741.1 residues 1 to 80 of 80 are 97.50 pct identical to residues 1 to 80 of 80 from Escherichia coli K-12 : B3257; hypothetical protein 3385271 yhdT 1079741 yhdT Shigella flexneri 2a str. 2457T hypothetical protein NP_838759.1 3385029 D 198215 CDS NP_838760.1 30064589 1078464 3385261..3386712 1 NC_004741.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3386712 panF 1078464 panF Shigella flexneri 2a str. 2457T sodium/panthothenate symporter NP_838760.1 3385261 D 198215 CDS NP_838761.1 30064590 1079743 3386724..3387605 1 NC_004741.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 3387605 prmA 1079743 prmA Shigella flexneri 2a str. 2457T 50S ribosomal protein L11 methyltransferase NP_838761.1 3386724 D 198215 CDS NP_838762.1 30064591 1079744 3388057..3388899 1 NC_004741.1 residues 1 to 280 of 280 are 99.64 pct identical to residues 42 to 321 of 321 from Escherichia coli K-12 : B3260; dehydrogenase 3388899 yhdG 1079744 yhdG Shigella flexneri 2a str. 2457T dehydrogenase NP_838762.1 3388057 D 198215 CDS NP_838763.1 30064592 1079745 3388925..3389221 1 NC_004741.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3389221 fis 1079745 fis Shigella flexneri 2a str. 2457T DNA-binding protein Fis NP_838763.1 3388925 D 198215 CDS NP_838764.1 30064593 1079687 3389307..3390191 1 NC_004741.1 residues 1 to 294 of 294 are 97.95 pct identical to residues 3 to 296 of 296 from Escherichia coli K-12 : B3262; methyltransferase 3390191 yhdJ 1079687 yhdJ Shigella flexneri 2a str. 2457T methyltransferase NP_838764.1 3389307 D 198215 CDS NP_838765.1 30064594 1079747 complement(3390469..3390972) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3390972 1079747 S3519 Shigella flexneri 2a str. 2457T IS1 orfB NP_838765.1 3390469 R 198215 CDS NP_838766.1 30064595 1079748 complement(3390891..3391166) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3391166 1079748 S3520 Shigella flexneri 2a str. 2457T IS1 orfA NP_838766.1 3390891 R 198215 CDS NP_838767.1 30064596 1079739 3391510..3392427 1 NC_004741.1 residues 1 to 305 of 305 are 99.01 pct identical to residues 1 to 305 of 305 from Escherichia coli K-12 : B3268; periplasmic binding transport protein 3392427 yhdW 1079739 yhdW Shigella flexneri 2a str. 2457T periplasmic binding transport protein NP_838767.1 3391510 D 198215 CDS NP_838768.1 30064597 1077904 complement(3393056..3393559) 1 NC_004741.1 residues 1 to 97 of 97 are 82.47 pct identical to residues 71 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS1 orfB 3393559 1077904 S3523 Shigella flexneri 2a str. 2457T IS1 orfB NP_838768.1 3393056 R 198215 CDS NP_838769.1 30064598 1079751 complement(3393478..3393753) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3393753 1079751 S3524 Shigella flexneri 2a str. 2457T IS1 orfA NP_838769.1 3393478 R 198215 CDS NP_838770.1 30064599 1079752 3394451..3395554 1 NC_004741.1 residues 1 to 367 of 367 are 98.91 pct identical to residues 2 to 368 of 368 from Escherichia coli K-12 : B3270; transport system permease 3395554 yhdY 1079752 yhdY Shigella flexneri 2a str. 2457T transport system permease NP_838770.1 3394451 D 198215 CDS NP_838771.1 30064600 1076480 3395562..3396320 1 NC_004741.1 residues 1 to 252 of 252 are 98.41 pct identical to residues 1 to 252 of 252 from Escherichia coli K-12 : B3271; ATP-binding component of a transport system 3396320 yhdZ 1076480 yhdZ Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_838771.1 3395562 D 198215 CDS NP_838772.1 30064601 1079758 3401985..3402755 1 NC_004741.1 residues 1 to 256 of 256 are 100.00 pct identical to residues 1 to 256 of 256 from Escherichia coli K-12 : B3279; transferase 3402755 yrdA 1079758 yrdA Shigella flexneri 2a str. 2457T transferase NP_838772.1 3401985 D 198215 CDS NP_838773.1 30064602 1079760 complement(3402731..3402988) 1 NC_004741.1 residues 1 to 85 of 85 are 100.00 pct identical to residues 1 to 85 of 85 from Escherichia coli K-12 : B3280; hypothetical protein 3402988 yrdB 1079760 yrdB Shigella flexneri 2a str. 2457T hypothetical protein NP_838773.1 3402731 R 198215 CDS NP_838774.1 30064603 1079761 complement(3402985..3403803) 1 NC_004741.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 3403803 aroE 1079761 aroE Shigella flexneri 2a str. 2457T shikimate 5-dehydrogenase NP_838774.1 3402985 R 198215 CDS NP_838775.1 30064604 1079762 complement(3403808..3404380) 1 NC_004741.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor 3404380 yrdC 1079762 yrdC Shigella flexneri 2a str. 2457T ribosome maturation factor NP_838775.1 3403808 R 198215 CDS NP_838776.1 30064605 1079764 complement(3404385..3404903) 1 NC_004741.1 residues 1 to 162 of 162 are 95.06 pct identical to residues 8 to 169 of 169 from Escherichia coli K-12 : B3283; DNA topoisomerase 3404903 yrdD 1079764 yrdD Shigella flexneri 2a str. 2457T DNA topoisomerase NP_838776.1 3404385 R 198215 CDS NP_838777.1 30064606 1079765 complement(3404956..3405414) 1 NC_004741.1 residues 1 to 152 of 152 are 100.00 pct identical to residues 6 to 157 of 157 from Escherichia coli K-12 : B3284; hypothetical protein 3405414 smg 1079765 smg Shigella flexneri 2a str. 2457T hypothetical protein NP_838777.1 3404956 R 198215 CDS NP_838778.1 30064607 1079766 complement(3405401..3406525) 1 NC_004741.1 residues 1 to 374 of 374 are 97.59 pct identical to residues 1 to 374 of 374 from NRprotein_Feb2003 : >ref|NP_289847.1| smf gene product [Escherichia coli O157:H7 EDL933] pir||C85993 hypothetical protein smf [imported] - Escherichia coli (strain O157:H7, substrain EDL933) gb|AAG58407.1|AE005555_7 smf gene product [Escherichia coli O157:H7 EDL933]; DNA protecting protein DprA 3406525 smf 1079766 smf Shigella flexneri 2a str. 2457T DNA protecting protein DprA NP_838778.1 3405401 R 198215 CDS NP_838779.1 30064608 1079767 3406690..3407199 1 NC_004741.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3407199 def 1079767 def Shigella flexneri 2a str. 2457T peptide deformylase NP_838779.1 3406690 D 198215 CDS NP_838780.1 30064609 1079768 3407214..3408161 1 NC_004741.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3408161 fmt 1079768 fmt Shigella flexneri 2a str. 2457T methionyl-tRNA formyltransferase NP_838780.1 3407214 D 198215 CDS NP_838781.1 30064610 1078522 3408207..3409496 1 NC_004741.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase B 3409496 sun 1078522 sun Shigella flexneri 2a str. 2457T 16S rRNA methyltransferase B NP_838781.1 3408207 D 198215 CDS NP_838782.1 30064611 1079769 3409518..3410894 1 NC_004741.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3410894 trkA 1079769 trkA Shigella flexneri 2a str. 2457T potassium transporter peripheral membrane component NP_838782.1 3409518 D 198215 CDS NP_838783.1 30064612 1079770 3411075..3411749 1 NC_004741.1 residues 1 to 224 of 224 are 99.55 pct identical to residues 1 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 3411749 1079770 S3547 Shigella flexneri 2a str. 2457T ISSfl3 orfA NP_838783.1 3411075 D 198215 CDS NP_838784.1 30064613 1079771 3411746..3412096 1 NC_004741.1 residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAK18528.1|AF348706_217 (AF348706) IS orf [Shigella flexneri]; ISSfl3 orfB 3412096 1079771 S3548 Shigella flexneri 2a str. 2457T ISSfl3 orfB NP_838784.1 3411746 D 198215 CDS NP_838785.1 30064614 1079772 3412093..3413694 1 NC_004741.1 residues 1 to 533 of 533 are 96.99 pct identical to residues 1 to 533 of 533 from GenPept : >gb|AAL72376.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfC 3413694 1079772 S3549 Shigella flexneri 2a str. 2457T ISSfl3 orfC NP_838785.1 3412093 D 198215 CDS NP_838786.1 30064615 1079773 complement(3413860..3415209) 1 NC_004741.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III 3415209 lysC 1079773 lysC Shigella flexneri 2a str. 2457T aspartate kinase III NP_838786.1 3413860 R 198215 CDS NP_838787.1 30064616 1079774 3415734..3417383 1 NC_004741.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 3417383 pgi 1079774 pgi Shigella flexneri 2a str. 2457T glucose-6-phosphate isomerase NP_838787.1 3415734 D 198215 CDS NP_838788.1 30064617 1076477 3417846..3418088 1 NC_004741.1 residues 1 to 80 of 80 are 98.75 pct identical to residues 1 to 80 of 80 from Escherichia coli K-12 : B4026; hypothetical protein 3418088 yjbE 1076477 yjbE Shigella flexneri 2a str. 2457T hypothetical protein NP_838788.1 3417846 D 198215 CDS NP_838789.1 30064618 1079776 3418172..3418840 1 NC_004741.1 residues 1 to 222 of 222 are 93.69 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 : B4027; hypothetical protein 3418840 yjbF 1079776 yjbF Shigella flexneri 2a str. 2457T hypothetical protein NP_838789.1 3418172 D 198215 CDS NP_838790.1 30064619 1079410 3418837..3419574 1 NC_004741.1 residues 1 to 245 of 245 are 90.20 pct identical to residues 1 to 245 of 245 from Escherichia coli K-12 : B4028; hypothetical protein 3419574 yjbG 1079410 yjbG Shigella flexneri 2a str. 2457T hypothetical protein NP_838790.1 3418837 D 198215 CDS NP_838791.1 30064620 1079777 3419574..3421670 1 NC_004741.1 residues 1 to 698 of 698 are 99.57 pct identical to residues 1 to 698 of 698 from Escherichia coli K-12 : B4029; hypothetical protein 3421670 yjbH 1079777 yjbH Shigella flexneri 2a str. 2457T hypothetical protein NP_838791.1 3419574 D 198215 CDS NP_838792.1 30064621 1080961 3422265..3422675 1 NC_004741.1 residues 1 to 136 of 136 are 84.55 pct identical to residues 1 to 136 of 136 from Escherichia coli K-12 : B4030; phosphate-starvation-inducible protein PsiE 3422675 yjbA 1080961 yjbA Shigella flexneri 2a str. 2457T phosphate-starvation-inducible protein PsiE NP_838792.1 3422265 D 198215 CDS NP_838793.1 30064622 1080770 complement(3422719..3424194) 1 NC_004741.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE 3424194 xylE 1080770 xylE Shigella flexneri 2a str. 2457T D-xylose transporter XylE NP_838793.1 3422719 R 198215 CDS NP_838794.1 30064623 1079778 complement(3424565..3425455) 1 NC_004741.1 with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease 3425455 malG 1079778 malG Shigella flexneri 2a str. 2457T maltose transporter permease NP_838794.1 3424565 R 198215 CDS NP_838795.1 30064624 1079779 complement(3425470..3427014) 1 NC_004741.1 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 3427014 malF 1079779 malF Shigella flexneri 2a str. 2457T maltose transporter membrane protein NP_838795.1 3425470 R 198215 CDS NP_838796.1 30064625 1079799 complement(3427168..3428358) 1 NC_004741.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein 3428358 malE 1079799 malE Shigella flexneri 2a str. 2457T maltose ABC transporter periplasmic protein NP_838796.1 3427168 R 198215 CDS NP_838797.1 30064626 1079780 3428723..3429838 1 NC_004741.1 with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 3429838 malK 1079780 malK Shigella flexneri 2a str. 2457T maltose/maltodextrin transporter ATP-binding protein NP_838797.1 3428723 D 198215 CDS NP_838798.1 30064627 1079781 3429913..3431250 1 NC_004741.1 porin involved in the transport of maltose and maltodextrins; maltoporin 3431250 lamB 1079781 lamB Shigella flexneri 2a str. 2457T maltoporin NP_838798.1 3429913 D 198215 CDS NP_838799.1 30064628 1079782 3431402..3432322 1 NC_004741.1 residues 1 to 306 of 306 are 80.71 pct identical to residues 1 to 306 of 306 from Escherichia coli K-12 : B4037; maltose regulon periplasmic protein 3432322 malM 1079782 malM Shigella flexneri 2a str. 2457T maltose regulon periplasmic protein NP_838799.1 3431402 D 198215 CDS NP_838800.1 30064629 1079290 3434354..3434851 1 NC_004741.1 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 3434851 ubiC 1079290 ubiC Shigella flexneri 2a str. 2457T chorismate pyruvate lyase NP_838800.1 3434354 D 198215 CDS NP_838801.1 30064630 1079784 3434864..3435736 1 NC_004741.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 3435736 ubiA 1079784 ubiA Shigella flexneri 2a str. 2457T 4-hydroxybenzoate octaprenyltransferase NP_838801.1 3434864 D 198215 CDS NP_838802.2 161486422 1079786 complement(3435891..3438314) 1 NC_004741.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 3438314 plsB 1079786 plsB Shigella flexneri 2a str. 2457T glycerol-3-phosphate acyltransferase NP_838802.2 3435891 R 198215 CDS NP_838803.1 30064632 1079787 3438485..3438853 1 NC_004741.1 residues 1 to 122 of 122 are 90.16 pct identical to residues 1 to 122 of 122 from Escherichia coli K-12 : B4042; diacylglycerol kinase 3438853 dgkA 1079787 dgkA Shigella flexneri 2a str. 2457T diacylglycerol kinase NP_838803.1 3438485 D 198215 CDS NP_838804.1 30064633 1079789 3438963..3439571 1 NC_004741.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 3439571 lexA 1079789 lexA Shigella flexneri 2a str. 2457T LexA repressor NP_838804.1 3438963 D 198215 CDS NP_838805.2 161486421 1079791 3439644..3440969 1 NC_004741.1 residues 1 to 459 of 459 are 83.22 pct identical to residues 1 to 459 of 459 from Escherichia coli K-12 : B4044; DNA-damage-inducible SOS response protein 3440969 dinF 1079791 dinF Shigella flexneri 2a str. 2457T DNA-damage-inducible SOS response protein NP_838805.2 3439644 D 198215 CDS NP_838806.1 30064635 1079792 3441085..3441294 1 NC_004741.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 3441294 yjbJ 1079792 yjbJ Shigella flexneri 2a str. 2457T stress-response protein NP_838806.1 3441085 D 198215 CDS NP_838807.2 161486420 1079794 complement(3441336..3441851) 1 NC_004741.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor 3441851 yjbK 1079794 yjbK Shigella flexneri 2a str. 2457T zinc uptake transcriptional repressor NP_838807.2 3441336 R 198215 CDS NP_838808.1 30064637 1079795 3442447..3443154 1 NC_004741.1 residues 1 to 235 of 235 are 90.63 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B4048; hypothetical protein 3443154 yjbM 1079795 yjbM Shigella flexneri 2a str. 2457T hypothetical protein NP_838808.1 3442447 D 198215 CDS NP_838809.1 30064638 1079796 3443535..3444554 1 NC_004741.1 residues 1 to 339 of 339 are 95.87 pct identical to residues 7 to 345 of 345 from Escherichia coli K-12 : B4049; tRNA-dihydrouridine synthase A 3444554 yjbN 1079796 yjbN Shigella flexneri 2a str. 2457T tRNA-dihydrouridine synthase A NP_838809.1 3443535 D 198215 CDS NP_838810.2 161486419 1077388 3444688..3444930 1 NC_004741.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 3444930 pspG 1077388 pspG Shigella flexneri 2a str. 2457T phage shock protein G NP_838810.2 3444688 D 198215 CDS NP_838811.1 30064640 1079797 complement(3445096..3446079) 1 NC_004741.1 residues 1 to 327 of 327 are 94.49 pct identical to residues 1 to 327 of 327 from Escherichia coli K-12 : B4051; quinone oxidoreductase, NADPH-dependent 3446079 qor 1079797 qor Shigella flexneri 2a str. 2457T quinone oxidoreductase, NADPH-dependent NP_838811.1 3445096 R 198215 CDS NP_838812.1 30064641 1079798 3446162..3447577 1 NC_004741.1 unwinds double stranded DNA; replicative DNA helicase 3447577 dnaB 1079798 dnaB Shigella flexneri 2a str. 2457T replicative DNA helicase NP_838812.1 3446162 D 198215 CDS NP_838813.1 30064642 1079800 3447630..3448709 1 NC_004741.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 3448709 alr 1079800 alr Shigella flexneri 2a str. 2457T alanine racemase NP_838813.1 3447630 D 198215 CDS NP_838814.1 30064643 1079801 3448962..3450155 1 NC_004741.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 3450155 tyrB 1079801 tyrB Shigella flexneri 2a str. 2457T aromatic amino acid aminotransferase NP_838814.1 3448962 D 198215 CDS NP_838815.1 30064644 1079802 3451264..3451977 1 NC_004741.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 3451977 aphA 1079802 aphA Shigella flexneri 2a str. 2457T acid phosphatase/phosphotransferase NP_838815.1 3451264 D 198215 CDS NP_838816.1 30064645 1079804 3452088..3452504 1 NC_004741.1 residues 1 to 138 of 138 are 99.27 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 : B4056; hypothetical protein 3452504 yjbQ 1079804 yjbQ Shigella flexneri 2a str. 2457T hypothetical protein NP_838816.1 3452088 D 198215 CDS NP_838817.1 30064646 1080937 3452508..3452864 1 NC_004741.1 residues 1 to 118 of 118 are 99.15 pct identical to residues 1 to 118 of 118 from Escherichia coli K-12 : B4057; hypothetical protein 3452864 yjbR 1080937 yjbR Shigella flexneri 2a str. 2457T hypothetical protein NP_838817.1 3452508 D 198215 CDS NP_838818.1 30064647 1079805 complement(3452899..3455721) 1 NC_004741.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 3455721 uvrA 1079805 uvrA Shigella flexneri 2a str. 2457T excinuclease ABC subunit A NP_838818.1 3452899 R 198215 CDS NP_838819.1 30064648 1079806 3455975..3456511 1 NC_004741.1 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 3456511 ssb 1079806 ssb Shigella flexneri 2a str. 2457T single-stranded DNA-binding protein NP_838819.1 3455975 D 198215 CDS NP_838820.1 30064649 1078153 complement(3456619..3457122) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 3457122 1078153 S3585 Shigella flexneri 2a str. 2457T IS1 orfB NP_838820.1 3456619 R 198215 CDS NP_838821.1 30064650 1079807 complement(3457041..3457316) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3457316 1079807 S3586 Shigella flexneri 2a str. 2457T IS1 orfA NP_838821.1 3457041 R 198215 CDS NP_838822.1 30064651 1079808 complement(3457386..3457736) 1 NC_004741.1 residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from Escherichia coli K-12 : B4060; hypothetical protein 3457736 yjcB 1079808 yjcB Shigella flexneri 2a str. 2457T hypothetical protein NP_838822.1 3457386 R 198215 CDS NP_838823.1 30064652 1076458 complement(3459676..3459999) 1 NC_004741.1 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 3459999 soxS 1076458 soxS Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator SoxS NP_838823.1 3459676 R 198215 CDS NP_838824.1 30064653 1079812 3460085..3460549 1 NC_004741.1 residues 1 to 154 of 154 are 100.00 pct identical to residues 1 to 154 of 154 from Escherichia coli K-12 : B4063; redox-sensing activator of soxS 3460549 soxR 1079812 soxR Shigella flexneri 2a str. 2457T redox-sensing activator of soxS NP_838824.1 3460085 D 198215 CDS NP_838825.1 30064654 1079813 3461255..3462604 1 NC_004741.1 residues 1 to 449 of 449 are 86.63 pct identical to residues 1 to 449 of 449 from Escherichia coli K-12 : B4064; hypothetical protein 3462604 yjcD 1079813 yjcD Shigella flexneri 2a str. 2457T hypothetical protein NP_838825.1 3461255 D 198215 CDS NP_838826.1 30064655 1079814 3462755..3464404 1 NC_004741.1 residues 1 to 527 of 549 are 85.95 pct identical to residues 1 to 527 of 549 from Escherichia coli K-12 : B4065; hypothetical protein 3464404 yjcE 1079814 yjcE Shigella flexneri 2a str. 2457T hypothetical protein NP_838826.1 3462755 D 198215 CDS NP_838827.1 30064656 1079815 complement(3464558..3465850) 1 NC_004741.1 residues 1 to 430 of 430 are 85.81 pct identical to residues 1 to 430 of 430 from Escherichia coli K-12 : B4066; hypothetical protein 3465850 yjcF 1079815 yjcF Shigella flexneri 2a str. 2457T hypothetical protein NP_838827.1 3464558 R 198215 CDS NP_838828.1 30064657 1078958 complement(3466028..3467677) 1 NC_004741.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease 3467677 actP 1078958 actP Shigella flexneri 2a str. 2457T acetate permease NP_838828.1 3466028 R 198215 CDS NP_838829.1 30064658 1080963 complement(3467674..3467988) 1 NC_004741.1 residues 1 to 104 of 104 are 89.42 pct identical to residues 1 to 104 of 104 from Escherichia coli K-12 : B4068; hypothetical protein 3467988 yjcH 1080963 yjcH Shigella flexneri 2a str. 2457T hypothetical protein NP_838829.1 3467674 R 198215 CDS NP_838830.1 30064659 1079817 3470539..3471975 1 NC_004741.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 3471975 nrfA 1079817 nrfA Shigella flexneri 2a str. 2457T cytochrome c552 NP_838830.1 3470539 D 198215 CDS NP_838831.1 30064660 1079818 3472020..3472586 1 NC_004741.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 3472586 nrfB 1079818 nrfB Shigella flexneri 2a str. 2457T cytochrome c nitrite reductase pentaheme subunit NP_838831.1 3472020 D 198215 CDS NP_838832.1 30064661 1079819 3472583..3473254 1 NC_004741.1 residues 1 to 223 of 223 are 100.00 pct identical to residues 1 to 223 of 223 from Escherichia coli K-12 : B4072; Fe-S centers; formate-dependent nitrite reductase 3473254 nrfC 1079819 nrfC Shigella flexneri 2a str. 2457T formate-dependent nitrite reductase NP_838832.1 3472583 D 198215 CDS NP_838833.1 30064662 1078385 3473251..3474207 1 NC_004741.1 residues 1 to 318 of 318 are 86.16 pct identical to residues 1 to 318 of 318 from Escherichia coli K-12 : B4073; formate-dependent nitrate reductase, transmembrane protein 3474207 nrfD 1078385 nrfD Shigella flexneri 2a str. 2457T formate-dependent nitrate reductase, transmembrane protein NP_838833.1 3473251 D 198215 CDS NP_838834.1 30064663 1079820 3474287..3475945 1 NC_004741.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 3475945 nrfE 1079820 nrfE Shigella flexneri 2a str. 2457T heme lyase subunit NrfE NP_838834.1 3474287 D 198215 CDS NP_838835.1 30064664 1079822 3475938..3476321 1 NC_004741.1 residues 1 to 102 of 127 are 86.27 pct identical to residues 1 to 102 of 127 from Escherichia coli K-12 : B4075; formate-dependent nitrite reductase complex subunit NrfF 3476321 nrfF 1079822 nrfF Shigella flexneri 2a str. 2457T formate-dependent nitrite reductase complex subunit NrfF NP_838835.1 3475938 D 198215 CDS NP_838836.1 30064665 1079823 3476318..3476914 1 NC_004741.1 residues 1 to 198 of 198 are 98.48 pct identical to residues 1 to 198 of 198 from Escherichia coli K-12 : B4076; formate-dependent nitrite reductase complex subunit NrfG 3476914 nrfG 1079823 nrfG Shigella flexneri 2a str. 2457T formate-dependent nitrite reductase complex subunit NrfG NP_838836.1 3476318 D 198215 CDS NP_838837.1 30064666 1079824 3477256..3478569 1 NC_004741.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 3478569 gltP 1079824 gltP Shigella flexneri 2a str. 2457T glutamate/aspartate:proton symporter NP_838837.1 3477256 D 198215 CDS NP_838838.1 30064667 1079825 complement(3478647..3479315) 1 NC_004741.1 residues 1 to 222 of 222 are 100.00 pct identical to residues 8 to 229 of 229 from Escherichia coli K-12 : B4078; hypothetical protein 3479315 yjcO 1079825 yjcO Shigella flexneri 2a str. 2457T hypothetical protein NP_838838.1 3478647 R 198215 CDS NP_838839.1 30064668 1079826 complement(3481775..3483241) 1 NC_004741.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; outer membrane efflux protein MdtP 3483241 yjcP 1079826 yjcP Shigella flexneri 2a str. 2457T outer membrane efflux protein MdtP NP_838839.1 3481775 R 198215 CDS NP_838840.2 161486418 1079827 complement(3483238..3485280) 1 NC_004741.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO 3485280 yjcQ 1079827 yjcQ Shigella flexneri 2a str. 2457T multidrug efflux system protein MdtO NP_838840.2 3483238 R 198215 CDS NP_838841.1 30064670 1079828 complement(3485280..3486311) 1 NC_004741.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN 3486311 yjcR 1079828 yjcR Shigella flexneri 2a str. 2457T multidrug resistance protein MdtN NP_838841.1 3485280 R 198215 CDS NP_838842.1 30064671 1079829 3486478..3486753 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3486753 1079829 S3609 Shigella flexneri 2a str. 2457T IS1 orfA NP_838842.1 3486478 D 198215 CDS NP_838843.1 30064672 1079830 3486672..3487175 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 3487175 1079830 S3610 Shigella flexneri 2a str. 2457T IS1 orfB NP_838843.1 3486672 D 198215 CDS NP_838844.1 30064673 1079831 complement(3487169..3487393) 1 NC_004741.1 residues 1 to 68 of 74 are 98.52 pct identical to residues 1 to 68 of 206 from Escherichia coli K-12 : B4104; membrane channel protein component of phosphonate transporter 3487393 phnE 1079831 phnE Shigella flexneri 2a str. 2457T membrane channel protein component of phosphonate transporter NP_838844.1 3487169 R 198215 CDS NP_838845.1 30064674 1079832 complement(3487448..3488464) 1 NC_004741.1 residues 1 to 338 of 338 are 98.52 pct identical to residues 1 to 338 of 338 from Escherichia coli K-12 : B4105; periplasmic binding protein component of phosphonate transporter 3488464 phnD 1079832 phnD Shigella flexneri 2a str. 2457T periplasmic binding protein component of phosphonate transporter NP_838845.1 3487448 R 198215 CDS NP_838846.1 30064675 1079833 complement(3488489..3489277) 1 NC_004741.1 residues 1 to 262 of 262 are 98.09 pct identical to residues 1 to 262 of 262 from Escherichia coli K-12 : B4106; phosphonate/organophosphate ester transporter subunit 3489277 phnC 1079833 phnC Shigella flexneri 2a str. 2457T phosphonate/organophosphate ester transporter subunit NP_838846.1 3488489 R 198215 CDS NP_838847.1 30064676 1079834 complement(3489410..3489853) 1 NC_004741.1 residues 1 to 147 of 147 are 99.31 pct identical to residues 1 to 147 of 147 from Escherichia coli K-12 : B4107; hypothetical protein 3489853 phnB 1079834 phnB Shigella flexneri 2a str. 2457T hypothetical protein NP_838847.1 3489410 R 198215 CDS NP_838848.1 30064677 1079835 complement(3490011..3490346) 1 NC_004741.1 residues 1 to 111 of 111 are 100.00 pct identical to residues 1 to 111 of 111 from Escherichia coli K-12 : B4108; hypothetical protein 3490346 phnA 1079835 phnA Shigella flexneri 2a str. 2457T hypothetical protein NP_838848.1 3490011 R 198215 CDS NP_838849.1 30064678 1079836 3490749..3492977 1 NC_004741.1 residues 1 to 742 of 742 are 95.28 pct identical to residues 1 to 742 of 742 from Escherichia coli K-12 : B4109; hypothetical protein 3492977 yjdA 1079836 yjdA Shigella flexneri 2a str. 2457T hypothetical protein NP_838849.1 3490749 D 198215 CDS NP_838850.1 30064679 1079837 3493007..3493852 1 NC_004741.1 residues 1 to 281 of 281 are 97.15 pct identical to residues 1 to 281 of 281 from Escherichia coli K-12 : B4110; hypothetical protein 3493852 yjcZ 1079837 yjcZ Shigella flexneri 2a str. 2457T hypothetical protein NP_838850.1 3493007 D 198215 CDS NP_838851.1 30064680 1079838 3494116..3495618 1 NC_004741.1 residues 1 to 500 of 500 are 97.00 pct identical to residues 1 to 500 of 500 from Escherichia coli K-12 : B4111; proline/glycine betaine transporter 3495618 proP 1079838 proP Shigella flexneri 2a str. 2457T proline/glycine betaine transporter NP_838851.1 3494116 D 198215 CDS NP_838852.1 30064681 1079839 complement(3495795..3496895) 1 NC_004741.1 residues 4 to 366 of 366 are 99.17 pct identical to residues 1 to 363 of 363 from Escherichia coli K-12 : B4112; sensor protein BasS/PmrB 3496895 basS 1079839 basS Shigella flexneri 2a str. 2457T sensor protein BasS/PmrB NP_838852.1 3495795 R 198215 CDS NP_838853.1 30064682 1079840 complement(3496896..3497564) 1 NC_004741.1 response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR 3497564 basR 1079840 basR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator BasR NP_838853.1 3496896 R 198215 CDS NP_838854.1 30064683 1079841 complement(3497561..3499234) 1 NC_004741.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein 3499234 yjdB 1079841 yjdB Shigella flexneri 2a str. 2457T cell division protein NP_838854.1 3497561 R 198215 CDS NP_838855.1 30064684 1079842 complement(3499308..3500645) 1 NC_004741.1 residues 1 to 445 of 445 are 92.35 pct identical to residues 1 to 445 of 445 from Escherichia coli K-12 : B4115; arginine:agmatin antiporter 3500645 yjdE 1079842 yjdE Shigella flexneri 2a str. 2457T arginine:agmatin antiporter NP_838855.1 3499308 R 198215 CDS NP_838856.1 30064685 1079843 complement(3500782..3501543) 1 NC_004741.1 residues 1 to 253 of 253 are 93.28 pct identical to residues 1 to 253 of 253 from Escherichia coli K-12 : B4116; ARAC-type regulatory protein 3501543 adiY 1079843 adiY Shigella flexneri 2a str. 2457T ARAC-type regulatory protein NP_838856.1 3500782 R 198215 CDS NP_838857.1 30064686 1079844 complement(3501868..3504135) 1 NC_004741.1 residues 1 to 755 of 755 are 99.47 pct identical to residues 2 to 756 of 756 from Escherichia coli K-12 : B4117; biodegradative arginine decarboxylase 3504135 adiA 1079844 adiA Shigella flexneri 2a str. 2457T biodegradative arginine decarboxylase NP_838857.1 3501868 R 198215 CDS NP_838858.1 30064687 1079845 complement(3504334..3505242) 1 NC_004741.1 residues 1 to 302 of 302 are 99.66 pct identical to residues 1 to 302 of 302 from Escherichia coli K-12 : B4118; DNA-binding transcriptional regulator MelR 3505242 melR 1079845 melR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator MelR NP_838858.1 3504334 R 198215 CDS NP_838859.1 30064688 1079846 3505525..3506880 1 NC_004741.1 residues 1 to 451 of 451 are 98.89 pct identical to residues 1 to 451 of 451 from Escherichia coli K-12 : B4119; alpha-galactosidase 3506880 melA 1079846 melA Shigella flexneri 2a str. 2457T alpha-galactosidase NP_838859.1 3505525 D 198215 CDS NP_838860.1 30064689 1079847 3506995..3508404 1 NC_004741.1 residues 1 to 469 of 469 are 96.37 pct identical to residues 1 to 469 of 469 from Escherichia coli K-12 : B4120; melibiose:sodium symporter 3508404 melB 1079847 melB Shigella flexneri 2a str. 2457T melibiose:sodium symporter NP_838860.1 3506995 D 198215 CDS NP_838861.1 30064690 1079848 complement(3508543..3509172) 1 NC_004741.1 residues 1 to 209 of 209 are 83.25 pct identical to residues 1 to 209 of 209 from Escherichia coli K-12 : B4121; hypothetical protein 3509172 yjdF 1079848 yjdF Shigella flexneri 2a str. 2457T hypothetical protein NP_838861.1 3508543 R 198215 CDS NP_838862.1 30064691 1079849 complement(3509295..3510941) 1 NC_004741.1 residues 1 to 548 of 548 are 96.35 pct identical to residues 1 to 548 of 548 from Escherichia coli K-12 : B4122; anaerobic isozyme; fumarase B, fumarate hydratase class I 3510941 fumB 1079849 fumB Shigella flexneri 2a str. 2457T fumarase B, fumarate hydratase class I NP_838862.1 3509295 R 198215 CDS NP_838863.1 30064692 1079850 complement(3511019..3512359) 1 NC_004741.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 3512359 dcuB 1079850 dcuB Shigella flexneri 2a str. 2457T anaerobic C4-dicarboxylate transporter NP_838863.1 3511019 R 198215 CDS NP_838864.1 30064693 1079851 complement(3512930..3513649) 1 NC_004741.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR 3513649 yjdG 1079851 yjdG Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator DcuR NP_838864.1 3512930 R 198215 CDS NP_838865.1 30064694 1079852 complement(3513646..3515277) 1 NC_004741.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS 3515277 yjdH 1079852 yjdH Shigella flexneri 2a str. 2457T sensory histidine kinase DcuS NP_838865.1 3513646 R 198215 CDS NP_838866.2 161486417 1079853 3515692..3516057 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3516057 1079853 S3633 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_838866.2 3515692 D 198215 CDS NP_838867.2 161486416 1079854 3516015..3516920 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3516920 1079854 S3634 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_838867.2 3516015 D 198215 CDS NP_838868.1 30064697 1079855 complement(3517246..3518118) 1 NC_004741.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 3518118 yjbC 1079855 yjbC Shigella flexneri 2a str. 2457T 23S rRNA pseudouridine synthase F NP_838868.1 3517246 R 198215 CDS NP_838869.1 30064698 1079856 3518466..3519413 1 NC_004741.1 residues 1 to 315 of 315 are 98.73 pct identical to residues 8 to 322 of 322 from GenPept : >gb|AAG59220.1|AE005634_10 (AE005634) transcriptional regulator of sorbose uptake and utilization genes [Escherichia coli O157:H7 EDL933]; sor-operon regulator 3519413 sorC 1079856 sorC Shigella flexneri 2a str. 2457T sor-operon regulator NP_838869.1 3518466 D 198215 CDS NP_838870.1 30064699 1079857 3519483..3520289 1 NC_004741.1 Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase 3520289 sorD 1079857 sorD Shigella flexneri 2a str. 2457T sorbitol-6-phosphate 2-dehydrogenase NP_838870.1 3519483 D 198215 CDS NP_838871.1 30064700 1079858 3520299..3520706 1 NC_004741.1 residues 1 to 135 of 135 are 97.03 pct identical to residues 1 to 135 of 135 from GenPept : >gb|AAG59218.1|AE005634_8 (AE005634) sorbose PTS component [Escherichia coli O157:H7 EDL933]; sorbose-permease PTS system IIA component 3520706 sorF 1079858 sorF Shigella flexneri 2a str. 2457T sorbose-permease PTS system IIA component NP_838871.1 3520299 D 198215 CDS NP_838872.1 30064701 1079859 3520706..3521200 1 NC_004741.1 residues 1 to 164 of 164 are 99.39 pct identical to residues 1 to 164 of 164 from GenPept : >gb|AAG59217.1|AE005634_7 (AE005634) sorbose PTS component [Escherichia coli O157:H7 EDL933]; sorbose-permease PTS system IIB component 3521200 sorB 1079859 sorB Shigella flexneri 2a str. 2457T sorbose-permease PTS system IIB component NP_838872.1 3520706 D 198215 CDS NP_838873.1 30064702 1079860 3521323..3522063 1 NC_004741.1 residues 1 to 246 of 246 are 86.99 pct identical to residues 20 to 265 of 265 from GenPept : >gb|AAG59216.1|AE005634_6 (AE005634) sorbose PTS component [Escherichia coli O157:H7 EDL933]; sorbose-permease PTS system IIC component 3522063 sorA 1079860 sorA Shigella flexneri 2a str. 2457T sorbose-permease PTS system IIC component NP_838873.1 3521323 D 198215 CDS NP_838874.1 30064703 1079861 3522074..3522862 1 NC_004741.1 residues 1 to 262 of 262 are 82.48 pct identical to residues 1 to 274 of 274 from GenPept : >gb|AAG59215.1|AE005634_5 (AE005634) sorbose PTS component [Escherichia coli O157:H7 EDL933]; sorbose-permease PTS system IID component 3522862 sorM 1079861 sorM Shigella flexneri 2a str. 2457T sorbose-permease PTS system IID component NP_838874.1 3522074 D 198215 CDS NP_838875.1 30064704 1079862 3522914..3524143 1 NC_004741.1 residues 1 to 409 of 409 are 95.11 pct identical to residues 5 to 413 of 413 from GenPept : >gb|AAG59214.1|AE005634_4 (AE005634) L-sorbose-1-P-reductase [Escherichia coli O157:H7 EDL933]; L-sorbose-1-P-reductase 3524143 sorE 1079862 sorE Shigella flexneri 2a str. 2457T L-sorbose-1-P-reductase NP_838875.1 3522914 D 198215 CDS NP_838876.1 30064705 1079863 3524525..3525214 1 NC_004741.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 3525214 pepE 1079863 pepE Shigella flexneri 2a str. 2457T peptidase E NP_838876.1 3524525 D 198215 CDS NP_838877.1 30064706 1079864 complement(3525305..3526936) 1 NC_004741.1 residues 16 to 543 of 543 are 87.50 pct identical to residues 16 to 543 of 543 from Escherichia coli K-12 : B4020; alpha helix protein 3526936 yjbB 1079864 yjbB Shigella flexneri 2a str. 2457T alpha helix protein NP_838877.1 3525305 R 198215 CDS NP_838878.1 30064707 1079865 complement(3527156..3530839) 1 NC_004741.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 3530839 metH 1079865 metH Shigella flexneri 2a str. 2457T B12-dependent methionine synthase NP_838878.1 3527156 R 198215 CDS NP_838879.2 161486415 1079866 3531039..3531863 1 NC_004741.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; IclR family transcriptional regulator 3531863 iclR 1079866 iclR Shigella flexneri 2a str. 2457T IclR family transcriptional regulator NP_838879.2 3531039 D 198215 CDS NP_838880.1 30064709 1079869 complement(3536254..3537558) 1 NC_004741.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; isocitrate lyase 3537558 aceA 1079869 aceA Shigella flexneri 2a str. 2457T isocitrate lyase NP_838880.1 3536254 R 198215 CDS NP_838881.1 30064710 1079871 complement(3539458..3540387) 1 NC_004741.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 3540387 metA 1079871 metA Shigella flexneri 2a str. 2457T homoserine O-succinyltransferase NP_838881.1 3539458 R 198215 CDS NP_838882.1 30064711 1079872 3540544..3540987 1 NC_004741.1 residues 1 to 146 of 147 are 96.57 pct identical to residues 1 to 146 of 147 from Escherichia coli K-12 : B4012; hypothetical protein 3540987 yjaB 1079872 yjaB Shigella flexneri 2a str. 2457T hypothetical protein NP_838882.1 3540544 D 198215 CDS NP_838883.1 30064712 1079877 3546727..3548316 1 NC_004741.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 3548316 purH 1079877 purH Shigella flexneri 2a str. 2457T bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NP_838883.1 3546727 D 198215 CDS NP_838884.1 30064713 1079878 3548328..3549617 1 NC_004741.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 3549617 purD 1079878 purD Shigella flexneri 2a str. 2457T phosphoribosylamine--glycine ligase NP_838884.1 3548328 D 198215 CDS NP_838885.1 30064714 1079879 complement(3549614..3550939) 1 NC_004741.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 3550939 hydG 1079879 hydG Shigella flexneri 2a str. 2457T transcriptional regulatory protein ZraR NP_838885.1 3549614 R 198215 CDS NP_838886.1 30064715 1079880 complement(3550936..3552312) 1 NC_004741.1 residues 1 to 458 of 458 are 74.40 pct identical to residues 1 to 465 of 465 from Escherichia coli K-12 : B4003; sensor protein ZraS 3552312 hydH 1079880 hydH Shigella flexneri 2a str. 2457T sensor protein ZraS NP_838886.1 3550936 R 198215 CDS NP_838887.2 161486414 1079881 3552550..3552975 1 NC_004741.1 residues 1 to 166 of 188 are 91.56 pct identical to residues 1 to 166 of 188 from Escherichia coli K-12 : B4002; zinc resistance protein 3552975 zraP 1079881 zraP Shigella flexneri 2a str. 2457T zinc resistance protein NP_838887.2 3552550 D 198215 CDS NP_838888.1 30064717 1079882 complement(3552977..3553672) 1 NC_004741.1 residues 1 to 231 of 231 are 94.37 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 : B4001; hypothetical protein 3553672 yjaH 1079882 yjaH Shigella flexneri 2a str. 2457T hypothetical protein NP_838888.1 3552977 R 198215 CDS NP_838889.1 30064718 1079883 complement(3553685..3553957) 1 NC_004741.1 histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 3553957 hupA 1079883 hupA Shigella flexneri 2a str. 2457T transcriptional regulator HU subunit alpha NP_838889.1 3553685 R 198215 CDS NP_838890.1 30064719 1079884 complement(3554144..3554734) 1 NC_004741.1 residues 1 to 196 of 196 are 98.97 pct identical to residues 1 to 196 of 196 from Escherichia coli K-12 : B3999; hypothetical protein 3554734 yjaG 1079884 yjaG Shigella flexneri 2a str. 2457T hypothetical protein NP_838890.1 3554144 R 198215 CDS NP_838891.1 30064720 1079885 complement(3554777..3555448) 1 NC_004741.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 3555448 nfi 1079885 nfi Shigella flexneri 2a str. 2457T endonuclease V NP_838891.1 3554777 R 198215 CDS NP_838892.1 30064721 1079886 complement(3555605..3556669) 1 NC_004741.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 3556669 hemE 1079886 hemE Shigella flexneri 2a str. 2457T uroporphyrinogen decarboxylase NP_838892.1 3555605 R 198215 CDS NP_838893.1 30064722 1079887 complement(3556709..3557482) 1 NC_004741.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 3557482 nudC 1079887 nudC Shigella flexneri 2a str. 2457T NADH pyrophosphatase NP_838893.1 3556709 R 198215 CDS NP_838894.1 30064723 1079888 3557577..3558053 1 NC_004741.1 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 3558053 yjaE 1079888 yjaE Shigella flexneri 2a str. 2457T anti-RNA polymerase sigma 70 factor NP_838894.1 3557577 D 198215 CDS NP_838895.1 30064724 1079889 3558287..3560182 1 NC_004741.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 3560182 thiC 1079889 thiC Shigella flexneri 2a str. 2457T thiamine biosynthesis protein ThiC NP_838895.1 3558287 D 198215 CDS NP_838896.1 30064725 1079890 3560182..3560817 1 NC_004741.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 3560817 thiE 1079890 thiE Shigella flexneri 2a str. 2457T thiamine-phosphate pyrophosphorylase NP_838896.1 3560182 D 198215 CDS NP_838897.1 30064726 1079891 3560810..3561565 1 NC_004741.1 catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate; thiamine biosynthesis protein ThiF 3561565 thiF 1079891 thiF Shigella flexneri 2a str. 2457T thiamine biosynthesis protein ThiF NP_838897.1 3560810 D 198215 CDS NP_838898.2 161486413 1079892 3561751..3562521 1 NC_004741.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 3562521 thiG 1079892 thiG Shigella flexneri 2a str. 2457T thiazole synthase NP_838898.2 3561751 D 198215 CDS NP_838899.1 30064728 1079893 3562518..3563651 1 NC_004741.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 3563651 thiH 1079893 thiH Shigella flexneri 2a str. 2457T thiamine biosynthesis protein ThiH NP_838899.1 3562518 D 198215 CDS NP_838900.1 30064729 1079894 complement(3563893..3568116) 1 NC_004741.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 3568116 rpoC 1079894 rpoC Shigella flexneri 2a str. 2457T DNA-directed RNA polymerase subunit beta' NP_838900.1 3563893 R 198215 CDS NP_838901.1 30064730 1079895 complement(3568193..3572221) 1 NC_004741.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 3572221 rpoB 1079895 rpoB Shigella flexneri 2a str. 2457T DNA-directed RNA polymerase subunit beta NP_838901.1 3568193 R 198215 CDS NP_838902.1 30064731 1079896 complement(3572541..3572906) 1 NC_004741.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 3572906 rplL 1079896 rplL Shigella flexneri 2a str. 2457T 50S ribosomal protein L7/L12 NP_838902.1 3572541 R 198215 CDS NP_838903.1 30064732 1079897 complement(3572973..3573470) 1 NC_004741.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 3573470 rplJ 1079897 rplJ Shigella flexneri 2a str. 2457T 50S ribosomal protein L10 NP_838903.1 3572973 R 198215 CDS NP_838904.1 30064733 1079898 complement(3573883..3574587) 1 NC_004741.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 3574587 rplA 1079898 rplA Shigella flexneri 2a str. 2457T 50S ribosomal protein L1 NP_838904.1 3573883 R 198215 CDS NP_838905.1 30064734 1079899 complement(3574591..3575019) 1 NC_004741.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 3575019 rplK 1079899 rplK Shigella flexneri 2a str. 2457T 50S ribosomal protein L11 NP_838905.1 3574591 R 198215 CDS NP_838906.1 30064735 1079733 complement(3575178..3575723) 1 NC_004741.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 3575723 nusG 1079733 nusG Shigella flexneri 2a str. 2457T transcription antitermination protein NusG NP_838906.1 3575178 R 198215 CDS NP_838907.1 30064736 1080964 complement(3575725..3576108) 1 NC_004741.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 3576108 secE 1080964 secE Shigella flexneri 2a str. 2457T preprotein translocase subunit SecE NP_838907.1 3575725 R 198215 CDS NP_838908.1 30064737 1079900 complement(3576338..3577522) 1 NC_004741.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 3577522 tuf 1079900 tuf Shigella flexneri 2a str. 2457T elongation factor Tu NP_838908.1 3576338 R 198215 CDS NP_838909.1 30064738 1079022 3578098..3578253 1 NC_004741.1 residues 1 to 51 of 51 are 98.03 pct identical to residues 1 to 51 of 51 from Escherichia coli K-12 : B3975; hypothetical protein 3578253 1079022 S3687 Shigella flexneri 2a str. 2457T hypothetical protein NP_838909.1 3578098 D 198215 CDS NP_838910.1 30064739 1079904 3578464..3579390 1 NC_004741.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 3579390 coaA 1079904 coaA Shigella flexneri 2a str. 2457T pantothenate kinase NP_838910.1 3578464 D 198215 CDS NP_838911.1 30064740 1079905 complement(3579419..3580384) 1 NC_004741.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 3580384 birA 1079905 birA Shigella flexneri 2a str. 2457T biotin--protein ligase NP_838911.1 3579419 R 198215 CDS NP_838912.1 30064741 1079906 complement(3580381..3581409) 1 NC_004741.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 3581409 murB 1079906 murB Shigella flexneri 2a str. 2457T UDP-N-acetylenolpyruvoylglucosamine reductase NP_838912.1 3580381 R 198215 CDS NP_838913.2 161486412 1079914 complement(3586922..3587779) 1 NC_004741.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 3587779 murI 1079914 murI Shigella flexneri 2a str. 2457T glutamate racemase NP_838913.2 3586922 R 198215 CDS NP_838914.1 30064743 1080549 complement(3587724..3589568) 1 NC_004741.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 3589568 btuB 1080549 btuB Shigella flexneri 2a str. 2457T vitamin B12/cobalamin outer membrane transporter NP_838914.1 3587724 R 198215 CDS NP_838915.1 30064744 1080805 3589937..3591037 1 NC_004741.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 3591037 trmA 1080805 trmA Shigella flexneri 2a str. 2457T tRNA (uracil-5-)-methyltransferase NP_838915.1 3589937 D 198215 CDS NP_838916.1 30064745 1079915 complement(3591077..3591436) 1 NC_004741.1 residues 1 to 119 of 119 are 99.15 pct identical to residues 1 to 119 of 119 from Escherichia coli K-12 : B3964; hypothetical protein 3591436 yijD 1079915 yijD Shigella flexneri 2a str. 2457T hypothetical protein NP_838916.1 3591077 R 198215 CDS NP_838917.1 30064746 1079913 complement(3591436..3592140) 1 NC_004741.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 3592140 yijC 1079913 yijC Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor FabR NP_838917.1 3591436 R 198215 CDS NP_838918.2 161486411 1079916 3592407..3593807 1 NC_004741.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 3593807 udhA 1079916 udhA Shigella flexneri 2a str. 2457T soluble pyridine nucleotide transhydrogenase NP_838918.2 3592407 D 198215 CDS NP_838919.1 30064748 1079917 complement(3593790..3594707) 1 NC_004741.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 3594707 oxyR 1079917 oxyR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator OxyR NP_838919.1 3593790 R 198215 CDS NP_838920.1 30064749 1076452 complement(3595902..3596405) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS1 orfB 3596405 1076452 S3704 Shigella flexneri 2a str. 2457T IS1 orfB NP_838920.1 3595902 R 198215 CDS NP_838921.1 30064750 1079920 complement(3596324..3596599) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3596599 1079920 S3705 Shigella flexneri 2a str. 2457T IS1 orfA NP_838921.1 3596324 R 198215 CDS NP_838922.1 30064751 1079921 complement(3597087..3598301) 1 NC_004741.1 residues 1 to 404 of 404 are 90.59 pct identical to residues 1 to 404 of 404 from Escherichia coli K-12 : B1581; sensor protein 3598301 1079921 S3707 Shigella flexneri 2a str. 2457T sensor protein NP_838922.1 3597087 R 198215 CDS NP_838923.1 30064752 1077001 complement(3598709..3600037) 1 NC_004741.1 residues 1 to 442 of 442 are 99.54 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 3600037 1077001 S3708 Shigella flexneri 2a str. 2457T IS4 orf NP_838923.1 3598709 R 198215 CDS NP_838924.1 30064753 1079922 complement(3600239..3601612) 1 NC_004741.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 3601612 argH 1079922 argH Shigella flexneri 2a str. 2457T argininosuccinate lyase NP_838924.1 3600239 R 198215 CDS NP_838925.1 30064754 1079923 complement(3601673..3602446) 1 NC_004741.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 3602446 argB 1079923 argB Shigella flexneri 2a str. 2457T acetylglutamate kinase NP_838925.1 3601673 R 198215 CDS NP_838926.1 30064755 1079925 complement(3602457..3603461) 1 NC_004741.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 3603461 argC 1079925 argC Shigella flexneri 2a str. 2457T N-acetyl-gamma-glutamyl-phosphate reductase NP_838926.1 3602457 R 198215 CDS NP_838927.1 30064756 1079926 3603615..3604766 1 NC_004741.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 3604766 argE 1079926 argE Shigella flexneri 2a str. 2457T acetylornithine deacetylase NP_838927.1 3603615 D 198215 CDS NP_838928.1 30064757 1079927 3605118..3607769 1 NC_004741.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 3607769 ppc 1079927 ppc Shigella flexneri 2a str. 2457T phosphoenolpyruvate carboxylase NP_838928.1 3605118 D 198215 CDS NP_838929.1 30064758 1079928 3607952..3609685 1 NC_004741.1 residues 1 to 577 of 577 are 94.80 pct identical to residues 1 to 577 of 577 from Escherichia coli K-12 : B3955; hypothetical protein 3609685 yijP 1079928 yijP Shigella flexneri 2a str. 2457T hypothetical protein NP_838929.1 3607952 D 198215 CDS NP_838930.1 30064759 1079929 3609834..3610685 1 NC_004741.1 residues 1 to 283 of 283 are 98.58 pct identical to residues 1 to 283 of 283 from Escherichia coli K-12 : B3954; ARAC-type regulatory protein 3610685 yijO 1079929 yijO Shigella flexneri 2a str. 2457T ARAC-type regulatory protein NP_838930.1 3609834 D 198215 CDS NP_838931.1 30064760 1079930 complement(3610672..3611013) 1 NC_004741.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; fructose-like phosphotransferase EIIB subunit 3 3611013 frwD 1079930 frwD Shigella flexneri 2a str. 2457T fructose-like phosphotransferase EIIB subunit 3 NP_838931.1 3610672 R 198215 CDS NP_838932.1 30064761 1079931 complement(3611015..3611893) 1 NC_004741.1 residues 1 to 292 of 292 are 94.86 pct identical to residues 1 to 292 of 292 from Escherichia coli K-12 : B3952; pyruvate formate lyase II activase 3611893 pflC 1079931 pflC Shigella flexneri 2a str. 2457T pyruvate formate lyase II activase NP_838932.1 3611015 R 198215 CDS NP_838933.1 30064762 1079982 complement(3611859..3614156) 1 NC_004741.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 3614156 pflD 1079982 pflD Shigella flexneri 2a str. 2457T formate acetyltransferase 2 NP_838933.1 3611859 R 198215 CDS NP_838934.1 30064763 1079932 complement(3614207..3614527) 1 NC_004741.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; fructose-like phosphotransferase EIIB subunit 2 3614527 frwB 1079932 frwB Shigella flexneri 2a str. 2457T fructose-like phosphotransferase EIIB subunit 2 NP_838934.1 3614207 R 198215 CDS NP_838935.1 30064764 1079933 complement(3614542..3615621) 1 NC_004741.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; fructose-like permease EIIC subunit 2 3615621 frwC 1079933 frwC Shigella flexneri 2a str. 2457T fructose-like permease EIIC subunit 2 NP_838935.1 3614542 R 198215 CDS NP_838936.1 30064765 1079940 complement(3622125..3624305) 1 NC_004741.1 residues 1 to 726 of 726 are 96.28 pct identical to residues 1 to 726 of 726 from Escherichia coli K-12 : B3942; catalase; hydroperoxidase HPI(I) 3624305 katG 1079940 katG Shigella flexneri 2a str. 2457T catalase; hydroperoxidase HPI(I) NP_838936.1 3622125 R 198215 CDS NP_838937.1 30064766 1079941 complement(3624634..3625524) 1 NC_004741.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 3625524 metF 1079941 metF Shigella flexneri 2a str. 2457T 5,10-methylenetetrahydrofolate reductase NP_838937.1 3624634 R 198215 CDS NP_838938.1 30064767 1079942 complement(3625873..3628305) 1 NC_004741.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 3628305 metL 1079942 metL Shigella flexneri 2a str. 2457T bifunctional aspartate kinase II/homoserine dehydrogenase II NP_838938.1 3625873 R 198215 CDS NP_838939.1 30064768 1079943 complement(3628308..3629468) 1 NC_004741.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 3629468 metB 1079943 metB Shigella flexneri 2a str. 2457T cystathionine gamma-synthase NP_838939.1 3628308 R 198215 CDS NP_838940.1 30064769 1079944 3629745..3630062 1 NC_004741.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 3630062 metJ 1079944 metJ Shigella flexneri 2a str. 2457T transcriptional repressor protein MetJ NP_838940.1 3629745 D 198215 CDS NP_838941.1 30064770 1079945 3630246..3630854 1 NC_004741.1 member of the NlpC/P60 superfamily of peptidases; peptidoglycan peptidase 3630854 yiiX 1079945 yiiX Shigella flexneri 2a str. 2457T peptidoglycan peptidase NP_838941.1 3630246 D 198215 CDS NP_838942.1 30064771 1079946 complement(3630915..3631127) 1 NC_004741.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 3631127 rpmE 1079946 rpmE Shigella flexneri 2a str. 2457T 50S ribosomal protein L31 NP_838942.1 3630915 R 198215 CDS NP_838943.1 30064772 1079391 3631330..3633528 1 NC_004741.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 3633528 priA 1079391 priA Shigella flexneri 2a str. 2457T primosome assembly protein PriA NP_838943.1 3631330 D 198215 CDS NP_838944.1 30064773 1080973 3633684..3634709 1 NC_004741.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 3634709 cytR 1080973 cytR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator CytR NP_838944.1 3633684 D 198215 CDS NP_838945.1 30064774 1079947 3634801..3635760 1 NC_004741.1 residues 1 to 319 of 319 are 76.48 pct identical to residues 1 to 319 of 319 from Escherichia coli K-12 : B3933; essential cell division protein FtsN 3635760 ftsN 1079947 ftsN Shigella flexneri 2a str. 2457T essential cell division protein FtsN NP_838945.1 3634801 D 198215 CDS NP_838946.1 30064775 1079949 3635853..3636383 1 NC_004741.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 3636383 hslV 1079949 hslV Shigella flexneri 2a str. 2457T ATP-dependent protease peptidase subunit NP_838946.1 3635853 D 198215 CDS NP_838947.1 30064776 1079950 3636393..3637724 1 NC_004741.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 3637724 hslU 1079950 hslU Shigella flexneri 2a str. 2457T ATP-dependent protease ATP-binding subunit HslU NP_838947.1 3636393 D 198215 CDS NP_838948.1 30064777 1079951 3637791..3638717 1 NC_004741.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 3638717 menA 1079951 menA Shigella flexneri 2a str. 2457T 1,4-dihydroxy-2-naphthoate octaprenyltransferase NP_838948.1 3637791 D 198215 CDS NP_838949.1 30064778 1078436 3638810..3639295 1 NC_004741.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 3639295 menG 1078436 menG Shigella flexneri 2a str. 2457T ribonuclease activity regulator protein RraA NP_838949.1 3638810 D 198215 CDS NP_838950.1 30064779 1079952 complement(3639380..3639625) 1 NC_004741.1 residues 1 to 81 of 81 are 100.00 pct identical to residues 1 to 81 of 81 from Escherichia coli K-12 : B3928; hypothetical protein 3639625 yiiU 1079952 yiiU Shigella flexneri 2a str. 2457T hypothetical protein NP_838950.1 3639380 R 198215 CDS NP_838951.1 30064780 1079953 3640051..3640695 1 NC_004741.1 residues 1 to 214 of 214 are 91.12 pct identical to residues 1 to 214 of 281 from Escherichia coli K-12 : B3927; glycerol diffusion facilitator protein 3640695 glpF 1079953 glpF Shigella flexneri 2a str. 2457T glycerol diffusion facilitator protein NP_838951.1 3640051 D 198215 CDS NP_838952.1 30064781 1079954 3640919..3642427 1 NC_004741.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 3642427 glpK 1079954 glpK Shigella flexneri 2a str. 2457T glycerol kinase NP_838952.1 3640919 D 198215 CDS NP_838953.1 30064782 1079955 3642657..3643667 1 NC_004741.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 3643667 glpX 1079955 glpX Shigella flexneri 2a str. 2457T fructose 1,6-bisphosphatase II NP_838953.1 3642657 D 198215 CDS NP_838954.1 30064783 1079956 3643764..3644510 1 NC_004741.1 residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 : B3924; ferredoxin-NADP reductase 3644510 fpr 1079956 fpr Shigella flexneri 2a str. 2457T ferredoxin-NADP reductase NP_838954.1 3643764 D 198215 CDS NP_838955.1 30064784 1079957 complement(3644515..3644943) 1 NC_004741.1 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 3644943 yiiT 1079957 yiiT Shigella flexneri 2a str. 2457T universal stress protein UspD NP_838955.1 3644515 R 198215 CDS NP_838956.1 30064785 1079958 complement(3644970..3645269) 1 NC_004741.1 residues 1 to 99 of 99 are 85.85 pct identical to residues 1 to 99 of 99 from Escherichia coli K-12 : B3922; hypothetical protein 3645269 yiiS 1079958 yiiS Shigella flexneri 2a str. 2457T hypothetical protein NP_838956.1 3644970 R 198215 CDS NP_838957.1 30064786 1079960 3646022..3646621 1 NC_004741.1 residues 1 to 199 of 199 are 95.97 pct identical to residues 1 to 199 of 199 from Escherichia coli K-12 : B3920; hypothetical protein 3646621 yiiQ 1079960 yiiQ Shigella flexneri 2a str. 2457T hypothetical protein NP_838957.1 3646022 D 198215 CDS NP_838958.1 30064787 1079961 3646729..3647496 1 NC_004741.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 3647496 tpiA 1079961 tpiA Shigella flexneri 2a str. 2457T triosephosphate isomerase NP_838958.1 3646729 D 198215 CDS NP_838959.1 30064788 1079963 complement(3647551..3648306) 1 NC_004741.1 residues 1 to 251 of 251 are 90.83 pct identical to residues 1 to 251 of 251 from Escherichia coli K-12 : B3918; CDP-diacylglycerol pyrophosphatase 3648306 cdh 1079963 cdh Shigella flexneri 2a str. 2457T CDP-diacylglycerol pyrophosphatase NP_838959.1 3647551 R 198215 CDS NP_838960.1 30064789 1079964 complement(3648413..3649402) 1 NC_004741.1 residues 1 to 329 of 329 are 96.65 pct identical to residues 1 to 329 of 329 from Escherichia coli K-12 : B3917; sulfate transporter subunit 3649402 sbp 1079964 sbp Shigella flexneri 2a str. 2457T sulfate transporter subunit NP_838960.1 3648413 R 198215 CDS NP_838961.1 30064790 1079965 complement(3649722..3650666) 1 NC_004741.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 3650666 pfkA 1079965 pfkA Shigella flexneri 2a str. 2457T 6-phosphofructokinase NP_838961.1 3649722 R 198215 CDS NP_838962.1 30064791 1079966 complement(3650865..3651767) 1 NC_004741.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 3651767 fieF 1079966 fieF Shigella flexneri 2a str. 2457T ferrous iron efflux protein F NP_838962.1 3650865 R 198215 CDS NP_838963.2 161486410 1079967 complement(3651915..3652415) 1 NC_004741.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP 3652415 cpxP 1079967 cpxP Shigella flexneri 2a str. 2457T periplasmic repressor CpxP NP_838963.2 3651915 R 198215 CDS NP_838964.1 30064793 1079969 3652565..3653263 1 NC_004741.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 3653263 cpxR 1079969 cpxR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator CpxR NP_838964.1 3652565 D 198215 CDS NP_838965.1 30064794 1079971 3653260..3654633 1 NC_004741.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 3654633 cpxA 1079971 cpxA Shigella flexneri 2a str. 2457T two-component sensor protein NP_838965.1 3653260 D 198215 CDS NP_838966.1 30064795 1079973 complement(3654739..3655413) 1 NC_004741.1 residues 1 to 224 of 224 are 92.85 pct identical to residues 11 to 234 of 234 from Escherichia coli K-12 : B3910; hypothetical protein 3655413 yiiM 1079973 yiiM Shigella flexneri 2a str. 2457T hypothetical protein NP_838966.1 3654739 R 198215 CDS NP_838967.2 161486409 1079974 3655640..3656005 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3656005 1079974 S3760 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_838967.2 3655640 D 198215 CDS NP_838968.2 161486408 1079975 3655963..3656868 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3656868 1079975 S3761 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_838968.2 3655963 D 198215 CDS NP_838969.1 30064798 1079976 complement(3656898..3657881) 1 NC_004741.1 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 3657881 kdgT 1079976 kdgT Shigella flexneri 2a str. 2457T 2-keto-3-deoxygluconate permease NP_838969.1 3656898 R 198215 CDS NP_838970.1 30064799 1079977 complement(3658141..3658761) 1 NC_004741.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 3658761 sodA 1079977 sodA Shigella flexneri 2a str. 2457T superoxide dismutase NP_838970.1 3658141 R 198215 CDS NP_838971.1 30064800 1079980 complement(3660077..3661015) 1 NC_004741.1 activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 3661015 rhaR 1079980 rhaR Shigella flexneri 2a str. 2457T transcriptional activator RhaR NP_838971.1 3660077 R 198215 CDS NP_838972.1 30064801 1079981 complement(3660999..3661835) 1 NC_004741.1 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 3661835 rhaS 1079981 rhaS Shigella flexneri 2a str. 2457T transcriptional activator RhaS NP_838972.1 3660999 R 198215 CDS NP_838973.1 30064802 1079984 3662123..3663592 1 NC_004741.1 catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 3663592 rhaB 1079984 rhaB Shigella flexneri 2a str. 2457T rhamnulokinase NP_838973.1 3662123 D 198215 CDS NP_838974.1 30064803 1079985 3663589..3664848 1 NC_004741.1 catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 3664848 rhaA 1079985 rhaA Shigella flexneri 2a str. 2457T L-rhamnose isomerase NP_838974.1 3663589 D 198215 CDS NP_838975.1 30064804 1079986 3665273..3665914 1 NC_004741.1 residues 1 to 213 of 213 are 99.06 pct identical to residues 62 to 274 of 274 from Escherichia coli K-12 : B3902; rhamnulose-1-phosphate aldolase 3665914 rhaD 1079986 rhaD Shigella flexneri 2a str. 2457T rhamnulose-1-phosphate aldolase NP_838975.1 3665273 D 198215 CDS NP_838976.1 30064805 1079987 3665924..3666238 1 NC_004741.1 residues 1 to 104 of 104 are 99.03 pct identical to residues 1 to 104 of 104 from Escherichia coli K-12 : B3901; hypothetical protein 3666238 yiiL 1079987 yiiL Shigella flexneri 2a str. 2457T hypothetical protein NP_838976.1 3665924 D 198215 CDS NP_838977.1 30064806 1079988 3666539..3666985 1 NC_004741.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; fructose-like phosphotransferase system subunit EIIA 3666985 frvA 1079988 frvA Shigella flexneri 2a str. 2457T fructose-like phosphotransferase system subunit EIIA NP_838977.1 3666539 D 198215 CDS NP_838978.1 30064807 1079989 3666996..3668447 1 NC_004741.1 residues 1 to 483 of 483 are 94.20 pct identical to residues 3 to 485 of 485 from Escherichia coli K-12 : B3899; PTS transporter components IIBC 3668447 frvB 1079989 frvB Shigella flexneri 2a str. 2457T PTS transporter components IIBC NP_838978.1 3666996 D 198215 CDS NP_838979.1 30064808 1079990 3668437..3669507 1 NC_004741.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; fructose-specific phosphotransferase system protein FrvX 3669507 frvX 1079990 frvX Shigella flexneri 2a str. 2457T fructose-specific phosphotransferase system protein FrvX NP_838979.1 3668437 D 198215 CDS NP_838980.1 30064809 1079991 3669507..3670157 1 NC_004741.1 residues 1 to 210 of 216 are 95.23 pct identical to residues 1 to 210 of 582 from Escherichia coli K-12 : B3897; frv operon regulatory protein 3670157 frvR 1079991 frvR Shigella flexneri 2a str. 2457T frv operon regulatory protein NP_838980.1 3669507 D 198215 CDS NP_838981.1 30064810 1079992 3670191..3670466 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3670466 1079992 S3775 Shigella flexneri 2a str. 2457T IS1 orfA NP_838981.1 3670191 D 198215 CDS NP_838982.1 30064811 1079993 3670385..3670888 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18549.1|AF348706_238 (AF348706) iso-IS1 orfB [Shigella flexneri]; IS1 orfB 3670888 1079993 S3776 Shigella flexneri 2a str. 2457T IS1 orfB NP_838982.1 3670385 D 198215 CDS NP_838983.1 30064812 1080955 complement(3670960..3671793) 1 NC_004741.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 3671793 fdhD 1080955 fdhD Shigella flexneri 2a str. 2457T formate dehydrogenase accessory protein NP_838983.1 3670960 R 198215 CDS NP_838984.1 30064813 1080965 3671987..3675037 1 NC_004741.1 residues 1 to 1016 of 1016 are 99.61 pct identical to residues 1 to 1016 of 1016 from Escherichia coli K-12 : B3894; selenocysteine; formate dehydrogenase-O, major subunit 3675037 fdoG 1080965 fdoG Shigella flexneri 2a str. 2457T formate dehydrogenase-O, major subunit NP_838984.1 3671987 D 198215 CDS NP_838985.1 30064814 1079994 3675050..3675952 1 NC_004741.1 residues 1 to 284 of 300 are 96.12 pct identical to residues 1 to 284 of 300 from Escherichia coli K-12 : B3893; formate dehydrogenase-O, iron-sulfur subunit 3675952 fdoH 1079994 fdoH Shigella flexneri 2a str. 2457T formate dehydrogenase-O, iron-sulfur subunit NP_838985.1 3675050 D 198215 CDS NP_838986.1 30064815 1079995 3675949..3676584 1 NC_004741.1 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 3676584 fdoI 1079995 fdoI Shigella flexneri 2a str. 2457T formate dehydrogenase-O subunit gamma NP_838986.1 3675949 D 198215 CDS NP_838987.1 30064816 1080020 3676581..3677510 1 NC_004741.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 3677510 fdhE 1080020 fdhE Shigella flexneri 2a str. 2457T formate dehydrogenase accessory protein FdhE NP_838987.1 3676581 D 198215 CDS NP_838988.1 30064817 1079996 complement(3677840..3678082) 1 NC_004741.1 residues 1 to 80 of 80 are 100.00 pct identical to residues 1 to 80 of 80 from Escherichia coli K-12 : B3890; hypothetical protein 3678082 yiiF 1079996 yiiF Shigella flexneri 2a str. 2457T hypothetical protein NP_838988.1 3677840 R 198215 CDS NP_838989.1 30064818 1079997 complement(3678300..3678545) 1 NC_004741.1 residues 1 to 81 of 81 are 98.76 pct identical to residues 1 to 81 of 81 from Escherichia coli K-12 : B3889; hypothetical protein 3678545 yiiE 1079997 yiiE Shigella flexneri 2a str. 2457T hypothetical protein NP_838989.1 3678300 R 198215 CDS NP_838990.1 30064819 1079998 complement(3679197..3680342) 1 NC_004741.1 residues 78 to 381 of 381 are 94.73 pct identical to residues 1 to 304 of 304 from NRprotein_Feb03 : >ref|NP_290516.1| Z5429 gene product [Escherichia coli O157:H7 EDL933] ref|NP_312840.1| hypothetical protein [Escherichia coli O157:H7] pir||D86077 hypothetical protein Z5429 [imported] - Escherichia coli (strain O157:H7, substrain EDL933) pir||E91230 hypothetical protein ECs4813 [imported] - Escher; hypothetical protein 3680342 1079998 S4827 Shigella flexneri 2a str. 2457T hypothetical protein NP_838990.1 3679197 R 198215 CDS NP_838991.1 30064820 1079999 complement(3680500..3680751) 1 NC_004741.1 residues 1 to 75 of 83 are 97.33 pct identical to residues 121 to 195 of 330 from NRprotein_Feb03 : >ref|NP_290515.1| Z5428 gene product [Escherichia coli O157:H7 EDL933] pir||C86077 hypothetical protein Z5428 [imported] - Escherichia coli (strain O157:H7, substrain EDL933) gb|AAG59079.1|AE005620_1 Z5428 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 3680751 1079999 S4828 Shigella flexneri 2a str. 2457T hypothetical protein NP_838991.1 3680500 R 198215 CDS NP_838992.1 30064821 1080000 3680897..3681172 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3681172 1080000 S3784 Shigella flexneri 2a str. 2457T IS1 orfA NP_838992.1 3680897 D 198215 CDS NP_838993.1 30064822 1080001 3681091..3681594 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3681594 1080001 S3785 Shigella flexneri 2a str. 2457T IS1 orfB NP_838993.1 3681091 D 198215 CDS NP_838994.1 30064823 1080936 complement(3682136..3683125) 1 NC_004741.1 residues 1 to 329 of 329 are 99.08 pct identical to residues 1 to 329 of 329 from Escherichia coli K-12 : B3888; acetyltransferase 3683125 yiiD 1080936 yiiD Shigella flexneri 2a str. 2457T acetyltransferase NP_838994.1 3682136 R 198215 CDS NP_838995.1 30064824 1080002 complement(3683122..3683559) 1 NC_004741.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 3683559 yihZ 1080002 yihZ Shigella flexneri 2a str. 2457T D-tyrosyl-tRNA(Tyr) deacylase NP_838995.1 3683122 R 198215 CDS NP_838996.1 30064825 1080003 complement(3683556..3684428) 1 NC_004741.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 3684428 rbn 1080003 rbn Shigella flexneri 2a str. 2457T ribonuclease BN NP_838996.1 3683556 R 198215 CDS NP_838997.1 30064826 1080004 complement(3684422..3685021) 1 NC_004741.1 residues 1 to 199 of 199 are 100.00 pct identical to residues 8 to 206 of 206 from Escherichia coli K-12 : B3885; phosphatase 3685021 yihX 1080004 yihX Shigella flexneri 2a str. 2457T phosphatase NP_838997.1 3684422 R 198215 CDS NP_838998.1 30064827 1080005 complement(3685120..3685905) 1 NC_004741.1 residues 1 to 261 of 261 are 99.61 pct identical to residues 9 to 269 of 269 from Escherichia coli K-12 : B3884; DEOR-type transcriptional regulator 3685905 yihW 1080005 yihW Shigella flexneri 2a str. 2457T DEOR-type transcriptional regulator NP_838998.1 3685120 R 198215 CDS NP_838999.1 30064828 1080006 complement(3685939..3686835) 1 NC_004741.1 residues 1 to 298 of 298 are 89.93 pct identical to residues 3 to 300 of 300 from Escherichia coli K-12 : B3883; kinase 3686835 yihV 1080006 yihV Shigella flexneri 2a str. 2457T kinase NP_838999.1 3685939 R 198215 CDS NP_839000.1 30064829 1080007 3687003..3687899 1 NC_004741.1 residues 1 to 298 of 298 are 90.60 pct identical to residues 1 to 298 of 298 from Escherichia coli K-12 : B3882; dehydrogenase 3687899 yihU 1080007 yihU Shigella flexneri 2a str. 2457T dehydrogenase NP_839000.1 3687003 D 198215 CDS NP_839001.1 30064830 1080008 3687923..3688801 1 NC_004741.1 residues 1 to 292 of 292 are 94.17 pct identical to residues 1 to 292 of 292 from Escherichia coli K-12 : B3881; aldolase 3688801 yihT 1080008 yihT Shigella flexneri 2a str. 2457T aldolase NP_839001.1 3687923 D 198215 CDS NP_839002.1 30064831 1080009 3688818..3690059 1 NC_004741.1 residues 1 to 413 of 413 are 99.51 pct identical to residues 6 to 418 of 418 from Escherichia coli K-12 : B3880; hypothetical protein 3690059 yihS 1080009 yihS Shigella flexneri 2a str. 2457T hypothetical protein NP_839002.1 3688818 D 198215 CDS NP_839003.1 30064832 1080010 3690197..3691099 1 NC_004741.1 residues 1 to 300 of 300 are 98.66 pct identical to residues 9 to 308 of 308 from Escherichia coli K-12 : B3879; aldose-1-epimerase 3691099 yihR 1080010 yihR Shigella flexneri 2a str. 2457T aldose-1-epimerase NP_839003.1 3690197 D 198215 CDS NP_839004.1 30064833 1080011 3691298..3693334 1 NC_004741.1 residues 1 to 678 of 678 are 97.49 pct identical to residues 1 to 678 of 678 from Escherichia coli K-12 : B3878; alpha-glucosidase 3693334 yihQ 1080011 yihQ Shigella flexneri 2a str. 2457T alpha-glucosidase NP_839004.1 3691298 D 198215 CDS NP_839005.1 30064834 1080013 3694797..3696200 1 NC_004741.1 residues 1 to 462 of 467 are 98.70 pct identical to residues 3 to 464 of 487 from Escherichia coli K-12 : B3876; permease 3696200 yihO 1080013 yihO Shigella flexneri 2a str. 2457T permease NP_839005.1 3694797 D 198215 CDS NP_839006.1 30064835 1080015 complement(3696613..3697116) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3697116 1080015 S3800 Shigella flexneri 2a str. 2457T IS1 orfB NP_839006.1 3696613 R 198215 CDS NP_839007.1 30064836 1080016 complement(3697035..3697310) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3697310 1080016 S3801 Shigella flexneri 2a str. 2457T IS1 orfA NP_839007.1 3697035 R 198215 CDS NP_839008.1 30064837 1080017 complement(3697339..3698397) 1 NC_004741.1 residues 1 to 344 of 352 are 95.93 pct identical to residues 1 to 344 of 421 from Escherichia coli K-12 : B3874; resistance protein 3698397 yihN 1080017 yihN Shigella flexneri 2a str. 2457T resistance protein NP_839008.1 3697339 R 198215 CDS NP_839009.1 30064838 1080018 complement(3698499..3699479) 1 NC_004741.1 residues 1 to 326 of 326 are 99.07 pct identical to residues 1 to 326 of 326 from Escherichia coli K-12 : B3873; hypothetical protein 3699479 yihM 1080018 yihM Shigella flexneri 2a str. 2457T hypothetical protein NP_839009.1 3698499 R 198215 CDS NP_839010.1 30064839 1080019 complement(3699487..3700197) 1 NC_004741.1 residues 1 to 236 of 236 are 100.00 pct identical to residues 1 to 236 of 236 from Escherichia coli K-12 : B3872; transcriptional regulator 3700197 yihL 1080019 yihL Shigella flexneri 2a str. 2457T transcriptional regulator NP_839010.1 3699487 R 198215 CDS NP_839011.1 30064840 1080929 complement(3700414..3702237) 1 NC_004741.1 residues 1 to 591 of 607 are 94.92 pct identical to residues 1 to 591 of 591 from Escherichia coli K-12 : B3871; GTP-binding protein 3702237 yihK 1080929 yihK Shigella flexneri 2a str. 2457T GTP-binding protein NP_839011.1 3700414 R 198215 CDS NP_839012.1 30064841 1080021 3702610..3704019 1 NC_004741.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 3704019 glnA 1080021 glnA Shigella flexneri 2a str. 2457T glutamine synthetase NP_839012.1 3702610 D 198215 CDS NP_839013.1 30064842 1080022 3704192..3705241 1 NC_004741.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 3705241 glnL 1080022 glnL Shigella flexneri 2a str. 2457T nitrogen regulation protein NR(II) NP_839013.1 3704192 D 198215 CDS NP_839014.1 30064843 1080023 3705253..3706662 1 NC_004741.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 3706662 glnG 1080023 glnG Shigella flexneri 2a str. 2457T nitrogen regulation protein NR(I) NP_839014.1 3705253 D 198215 CDS NP_839015.1 30064844 1080024 complement(3707113..3708486) 1 NC_004741.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3708486 hemN 1080024 hemN Shigella flexneri 2a str. 2457T coproporphyrinogen III oxidase NP_839015.1 3707113 R 198215 CDS NP_839016.1 30064845 1080025 complement(3708675..3709184) 1 NC_004741.1 residues 1 to 169 of 169 are 78.69 pct identical to residues 1 to 169 of 169 from Escherichia coli K-12 : B3866; hypothetical protein 3709184 yihI 1080025 yihI Shigella flexneri 2a str. 2457T hypothetical protein NP_839016.1 3708675 R 198215 CDS NP_839017.2 161486407 1080026 3709766..3710398 1 NC_004741.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 3710398 engB 1080026 engB Shigella flexneri 2a str. 2457T ribosome biogenesis GTP-binding protein YsxC NP_839017.2 3709766 D 198215 CDS NP_839018.1 30064847 1080028 complement(3710780..3713566) 1 NC_004741.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 3713566 polA 1080028 polA Shigella flexneri 2a str. 2457T DNA polymerase I NP_839018.1 3710780 R 198215 CDS NP_839019.1 30064848 1080029 3713930..3714862 1 NC_004741.1 residues 1 to 310 of 310 are 91.93 pct identical to residues 1 to 310 of 310 from Escherichia coli K-12 : B3862; acyltransferase 3714862 yihG 1080029 yihG Shigella flexneri 2a str. 2457T acyltransferase NP_839019.1 3713930 D 198215 CDS NP_839020.1 30064849 1080030 complement(3714903..3716375) 1 NC_004741.1 residues 1 to 490 of 490 are 97.14 pct identical to residues 1 to 490 of 490 from Escherichia coli K-12 : B3861; hypothetical protein 3716375 yihF 1080030 yihF Shigella flexneri 2a str. 2457T hypothetical protein NP_839020.1 3714903 R 198215 CDS NP_839021.1 30064850 1080031 complement(3716488..3717114) 1 NC_004741.1 residues 1 to 208 of 208 are 99.51 pct identical to residues 1 to 208 of 208 from Escherichia coli K-12 : B3860; essential for cytochrome c synthesis and formate-dependent reduction; periplasmic protein disulfide isomerase I 3717114 dsbA 1080031 dsbA Shigella flexneri 2a str. 2457T periplasmic protein disulfide isomerase I NP_839021.1 3716488 R 198215 CDS NP_839022.1 30064851 1080032 complement(3717131..3718117) 1 NC_004741.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 3718117 yihE 1080032 yihE Shigella flexneri 2a str. 2457T serine/threonine protein kinase NP_839022.1 3717131 R 198215 CDS NP_839023.1 30064852 1080033 complement(3718194..3718463) 1 NC_004741.1 residues 1 to 89 of 89 are 98.87 pct identical to residues 1 to 89 of 89 from Escherichia coli K-12 : B3858; hypothetical protein 3718463 yihD 1080033 yihD Shigella flexneri 2a str. 2457T hypothetical protein NP_839023.1 3718194 R 198215 CDS NP_839024.1 30064853 1080034 3718533..3719117 1 NC_004741.1 Links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A 3719117 mobA 1080034 mobA Shigella flexneri 2a str. 2457T molybdopterin-guanine dinucleotide biosynthesis protein A NP_839024.1 3718533 D 198215 CDS NP_839025.1 30064854 1080035 3719099..3719626 1 NC_004741.1 residues 6 to 175 of 175 are 98.82 pct identical to residues 1 to 170 of 170 from Escherichia coli K-12 : B3856; molybdopterin-guanine dinucleotide biosynthesis protein B 3719626 mobB 1080035 mobB Shigella flexneri 2a str. 2457T molybdopterin-guanine dinucleotide biosynthesis protein B NP_839025.1 3719099 D 198215 CDS NP_839026.1 30064855 1080042 complement(3725208..3725753) 1 NC_004741.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 3725753 hemG 1080042 hemG Shigella flexneri 2a str. 2457T protoporphyrinogen oxidase NP_839026.1 3725208 R 198215 CDS NP_839027.1 30064856 1080043 complement(3725765..3727216) 1 NC_004741.1 residues 1 to 417 of 483 are 93.28 pct identical to residues 1 to 417 of 432 from Escherichia coli K-12 : B3849; requires trkE; potassium transporter 3727216 trkH 1080043 trkH Shigella flexneri 2a str. 2457T potassium transporter NP_839027.1 3725765 R 198215 CDS NP_839028.1 30064857 1080044 complement(3727255..3727869) 1 NC_004741.1 residues 1 to 204 of 204 are 94.60 pct identical to residues 2 to 205 of 205 from Escherichia coli K-12 : B3848; hypothetical protein 3727869 yigZ 1080044 yigZ Shigella flexneri 2a str. 2457T hypothetical protein NP_839028.1 3727255 R 198215 CDS NP_839029.1 30064858 1080045 complement(3727869..3729200) 1 NC_004741.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 3729200 pepQ 1080045 pepQ Shigella flexneri 2a str. 2457T proline dipeptidase NP_839029.1 3727869 R 198215 CDS NP_839030.1 30064859 1080046 3729390..3731579 1 NC_004741.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 3731579 fadB 1080046 fadB Shigella flexneri 2a str. 2457T multifunctional fatty acid oxidation complex subunit alpha NP_839030.1 3729390 D 198215 CDS NP_839031.1 30064860 1080047 3731589..3732752 1 NC_004741.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 3732752 fadA 1080047 fadA Shigella flexneri 2a str. 2457T 3-ketoacyl-CoA thiolase NP_839031.1 3731589 D 198215 CDS NP_839032.1 30064861 1080048 complement(3732944..3733645) 1 NC_004741.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 3733645 fre 1080048 fre Shigella flexneri 2a str. 2457T FMN reductase NP_839032.1 3732944 R 198215 CDS NP_839033.1 30064862 1080049 complement(3733691..3735184) 1 NC_004741.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 3735184 yigC 1080049 yigC Shigella flexneri 2a str. 2457T 3-octaprenyl-4-hydroxybenzoate carboxy-lyase NP_839033.1 3733691 R 198215 CDS NP_839034.1 30064863 1080050 3735351..3735839 1 NC_004741.1 residues 1 to 162 of 162 are 98.76 pct identical to residues 1 to 162 of 162 from Escherichia coli K-12 : B3842; affects biosynthesis of lipopolysaccharide core, F pilin, and hemolysin; transcriptional activator RfaH 3735839 rfaH 1080050 rfaH Shigella flexneri 2a str. 2457T transcriptional activator RfaH NP_839034.1 3735351 D 198215 CDS NP_839035.1 30064864 1080051 complement(3735836..3736618) 1 NC_004741.1 magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 3736618 yigW 1080051 yigW Shigella flexneri 2a str. 2457T DNase TatD NP_839035.1 3735836 R 198215 CDS NP_839036.1 30064865 1080052 complement(3736660..3737436) 1 NC_004741.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 3737436 yigU 1080052 yigU Shigella flexneri 2a str. 2457T twin-arginine protein translocation system subunit TatC NP_839036.1 3736660 R 198215 CDS NP_839037.1 30064866 1080053 complement(3737439..3737954) 1 NC_004741.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 3737954 1080053 S3838 Shigella flexneri 2a str. 2457T sec-independent translocase NP_839037.1 3737439 R 198215 CDS NP_839038.1 30064867 1080055 complement(3737958..3738269) 1 NC_004741.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase A 3738269 tatA 1080055 tatA Shigella flexneri 2a str. 2457T twin arginine translocase A NP_839038.1 3737958 R 198215 CDS NP_839039.1 30064868 1080056 complement(3738306..3739946) 1 NC_004741.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 3739946 ubiB 1080056 ubiB Shigella flexneri 2a str. 2457T ubiquinone biosynthesis protein UbiB NP_839039.1 3738306 R 198215 CDS NP_839040.1 30064869 1080057 complement(3739943..3740548) 1 NC_004741.1 residues 1 to 201 of 201 are 100.00 pct identical to residues 1 to 201 of 201 from Escherichia coli K-12 : B3834; hypothetical protein 3740548 yigP 1080057 yigP Shigella flexneri 2a str. 2457T hypothetical protein NP_839040.1 3739943 R 198215 CDS NP_839041.1 30064870 1080058 complement(3740562..3741317) 1 NC_004741.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 3741317 ubiE 1080058 ubiE Shigella flexneri 2a str. 2457T ubiquinone/menaquinone biosynthesis methyltransferase NP_839041.1 3740562 R 198215 CDS NP_839042.1 30064871 1080059 complement(3741412..3742824) 1 NC_004741.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 3742824 yigN 1080059 yigN Shigella flexneri 2a str. 2457T DNA recombination protein RmuC NP_839042.1 3741412 R 198215 CDS NP_839043.1 30064872 1080060 complement(3742980..3743741) 1 NC_004741.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 3743741 udp 1080060 udp Shigella flexneri 2a str. 2457T uridine phosphorylase NP_839043.1 3742980 R 198215 CDS NP_839044.1 30064873 1080062 complement(3744111..3744419) 1 NC_004741.1 no significant similarities; hypothetical protein 3744419 1080062 S3847 Shigella flexneri 2a str. 2457T hypothetical protein NP_839044.1 3744111 R 198215 CDS NP_839045.1 30064874 1080063 complement(3744856..3747117) 1 NC_004741.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 3747117 metE 1080063 metE Shigella flexneri 2a str. 2457T 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase NP_839045.1 3744856 R 198215 CDS NP_839046.1 30064875 1080064 3747353..3748306 1 NC_004741.1 residues 1 to 317 of 317 are 94.95 pct identical to residues 1 to 317 of 317 from Escherichia coli K-12 : B3828; regulator for metE and metH 3748306 metR 1080064 metR Shigella flexneri 2a str. 2457T regulator for metE and metH NP_839046.1 3747353 D 198215 CDS NP_839047.1 30064876 1080065 complement(3748194..3749093) 1 NC_004741.1 residues 1 to 299 of 299 are 94.64 pct identical to residues 1 to 299 of 299 from Escherichia coli K-12 : B3827; hypothetical protein 3749093 yigM 1080065 yigM Shigella flexneri 2a str. 2457T hypothetical protein NP_839047.1 3748194 R 198215 CDS NP_839048.1 30064877 1080066 complement(3749169..3749969) 1 NC_004741.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase 3749969 yigL 1080066 yigL Shigella flexneri 2a str. 2457T sugar phosphatase NP_839048.1 3749169 R 198215 CDS NP_839049.1 30064878 1080067 complement(3749977..3750999) 1 NC_004741.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 3750999 pldB 1080067 pldB Shigella flexneri 2a str. 2457T lysophospholipase L2 NP_839049.1 3749977 R 198215 CDS NP_839050.1 30064879 1080068 3751314..3751730 1 NC_004741.1 residues 1 to 138 of 138 are 87.68 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 : B3824; hypothetical protein 3751730 yigK 1080068 yigK Shigella flexneri 2a str. 2457T hypothetical protein NP_839050.1 3751314 D 198215 CDS NP_839051.1 30064880 1080069 complement(3751792..3752160) 1 NC_004741.1 residues 1 to 122 of 122 are 90.16 pct identical to residues 1 to 122 of 122 from Escherichia coli K-12 : B3823; hypothetical protein 3752160 yigJ 1080069 yigJ Shigella flexneri 2a str. 2457T hypothetical protein NP_839051.1 3751792 R 198215 CDS NP_839052.1 30064881 1080071 complement(3752476..3754311) 1 NC_004741.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 3754311 recQ 1080071 recQ Shigella flexneri 2a str. 2457T ATP-dependent DNA helicase RecQ NP_839052.1 3752476 R 198215 CDS NP_839053.1 30064882 1080073 complement(3754438..3755307) 1 NC_004741.1 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 3755307 pldA 1080073 pldA Shigella flexneri 2a str. 2457T phospholipase A NP_839053.1 3754438 R 198215 CDS NP_839054.2 161486406 1080074 3755472..3755939 1 NC_004741.1 residues 1 to 161 of 161 are 100.00 pct identical to residues 1 to 161 of 161 from Escherichia coli K-12 : B3820; hypothetical protein 3755939 yigI 1080074 yigI Shigella flexneri 2a str. 2457T hypothetical protein NP_839054.2 3755472 D 198215 CDS NP_839055.1 30064884 1080076 3755991..3756881 1 NC_004741.1 residues 4 to 296 of 296 are 92.49 pct identical to residues 8 to 300 of 300 from Escherichia coli K-12 : B3819; hypothetical protein 3756881 rarD 1080076 rarD Shigella flexneri 2a str. 2457T hypothetical protein NP_839055.1 3755991 D 198215 CDS NP_839056.1 30064885 1080079 3756940..3757356 1 NC_004741.1 residues 1 to 138 of 138 are 82.60 pct identical to residues 1 to 138 of 138 from Escherichia coli K-12 : B3818; hypothetical protein 3757356 yigG 1080079 yigG Shigella flexneri 2a str. 2457T hypothetical protein NP_839056.1 3756940 D 198215 CDS NP_839057.1 30064886 1080080 3757370..3757750 1 NC_004741.1 residues 1 to 126 of 126 are 99.20 pct identical to residues 1 to 126 of 126 from Escherichia coli K-12 : B3817; hypothetical protein 3757750 yigF 1080080 yigF Shigella flexneri 2a str. 2457T hypothetical protein NP_839057.1 3757370 D 198215 CDS NP_839058.1 30064887 1078848 complement(3757791..3758741) 1 NC_004741.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 3758741 corA 1078848 corA Shigella flexneri 2a str. 2457T magnesium/nickel/cobalt transporter CorA NP_839058.1 3757791 R 198215 CDS NP_839059.1 30064888 1076670 3759111..3759449 1 NC_004741.1 residues 1 to 112 of 112 are 98.21 pct identical to residues 1 to 112 of 161 from Escherichia coli K-12 : B3815; hypothetical protein 3759449 yigE 1076670 yigE Shigella flexneri 2a str. 2457T hypothetical protein NP_839059.1 3759111 D 198215 CDS NP_839060.1 30064889 1080082 complement(3759460..3760788) 1 NC_004741.1 residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 3760788 1080082 S3863 Shigella flexneri 2a str. 2457T IS4 orf NP_839060.1 3759460 R 198215 CDS NP_839061.1 30064890 1080083 3761014..3761313 1 NC_004741.1 residues 1 to 99 of 99 are 97.97 pct identical to residues 1 to 99 of 99 from Escherichia coli K-12 : B3814; hypothetical protein 3761313 1080083 S3864 Shigella flexneri 2a str. 2457T hypothetical protein NP_839061.1 3761014 D 198215 CDS NP_839062.1 30064891 1076646 complement(3761460..3763622) 1 NC_004741.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 3763622 uvrD 1076646 uvrD Shigella flexneri 2a str. 2457T DNA-dependent helicase II NP_839062.1 3761460 R 198215 CDS NP_839063.1 30064892 1080084 complement(3763706..3764422) 1 NC_004741.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 3764422 yigB 1080084 yigB Shigella flexneri 2a str. 2457T flavin mononucleotide phosphatase NP_839063.1 3763706 R 198215 CDS NP_839064.1 30064893 1080085 complement(3764422..3765318) 1 NC_004741.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 3765318 xerC 1080085 xerC Shigella flexneri 2a str. 2457T site-specific tyrosine recombinase XerC NP_839064.1 3764422 R 198215 CDS NP_839065.1 30064894 1080086 complement(3765315..3766022) 1 NC_004741.1 residues 1 to 235 of 235 are 95.74 pct identical to residues 1 to 235 of 235 from Escherichia coli K-12 : B3810; hypothetical protein 3766022 yigA 1080086 yigA Shigella flexneri 2a str. 2457T hypothetical protein NP_839065.1 3765315 R 198215 CDS NP_839066.2 161486405 1080088 complement(3766019..3766843) 1 NC_004741.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 3766843 dapF 1080088 dapF Shigella flexneri 2a str. 2457T diaminopimelate epimerase NP_839066.2 3766019 R 198215 CDS NP_839067.1 30064896 1080089 complement(3766880..3767083) 1 NC_004741.1 residues 1 to 67 of 67 are 100.00 pct identical to residues 1 to 67 of 67 from GenPept : >gb|AAG59001.1|AE005612_4 (AE005612) Z5325 gene product [Escherichia coli O157:H7 EDL933]; outer membrane lipoprotein 3767083 yifL 1080089 yifL Shigella flexneri 2a str. 2457T outer membrane lipoprotein NP_839067.1 3766880 R 198215 CDS NP_839068.1 30064897 1080090 3767386..3768423 1 NC_004741.1 residues 1 to 342 of 345 are 69.59 pct identical to residues 39 to 380 of 669 from GenPept : >emb|CAD09375.1| (AL627279) possible exported protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 3768423 1080090 S3871 Shigella flexneri 2a str. 2457T hypothetical protein NP_839068.1 3767386 D 198215 CDS NP_839069.1 30064898 1080092 complement(3769659..3770162) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS1 orfB 3770162 1080092 S3874 Shigella flexneri 2a str. 2457T IS1 orfB NP_839069.1 3769659 R 198215 CDS NP_839070.1 30064899 1080093 complement(3770081..3770356) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3770356 1080093 S3875 Shigella flexneri 2a str. 2457T IS1 orfA NP_839070.1 3770081 R 198215 CDS NP_839071.1 30064900 1080095 3770885..3771205 1 NC_004741.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 3771205 cyaY 1080095 cyaY Shigella flexneri 2a str. 2457T frataxin-like protein NP_839071.1 3770885 D 198215 CDS NP_839072.1 30064901 1080096 complement(3771245..3773791) 1 NC_004741.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 3773791 cyaA 1080096 cyaA Shigella flexneri 2a str. 2457T adenylate cyclase NP_839072.1 3771245 R 198215 CDS NP_839073.1 30064902 1080097 3774178..3775119 1 NC_004741.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 3775119 hemC 1080097 hemC Shigella flexneri 2a str. 2457T porphobilinogen deaminase NP_839073.1 3774178 D 198215 CDS NP_839074.1 30064903 1080098 3775116..3775856 1 NC_004741.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 3775856 hemD 1080098 hemD Shigella flexneri 2a str. 2457T uroporphyrinogen-III synthase NP_839074.1 3775116 D 198215 CDS NP_839075.1 30064904 1080099 3775878..3777077 1 NC_004741.1 residues 1 to 367 of 399 are 88.01 pct identical to residues 1 to 367 of 393 from Escherichia coli K-12 : B3803; uroporphyrinogen III C-methyltransferase 3777077 hemX 1080099 hemX Shigella flexneri 2a str. 2457T uroporphyrinogen III C-methyltransferase NP_839075.1 3775878 D 198215 CDS NP_839076.1 30064905 1080100 3777080..3778276 1 NC_004741.1 residues 19 to 398 of 398 are 92.63 pct identical to residues 19 to 398 of 398 from Escherichia coli K-12 : B3802; involved in late step of protohemeiX synthesis; protoheme IX biogenesis protein 3778276 hemY 1080100 hemY Shigella flexneri 2a str. 2457T protoheme IX biogenesis protein NP_839076.1 3777080 D 198215 CDS NP_839077.2 161486404 1080101 3779138..3779503 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3779503 1080101 S3883 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_839077.2 3779138 D 198215 CDS NP_839078.2 161486403 1080102 3779461..3780366 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3780366 1080102 S3884 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_839078.2 3779461 D 198215 CDS NP_839079.1 30064908 1080103 complement(3780536..3781771) 1 NC_004741.1 residues 1 to 411 of 411 are 96.10 pct identical to residues 1 to 411 of 411 from Escherichia coli K-12 : B3800; arylsulfatase regulator 3781771 aslB 1080103 aslB Shigella flexneri 2a str. 2457T arylsulfatase regulator NP_839079.1 3780536 R 198215 CDS NP_839080.1 30064909 1080109 complement(3782457..3783842) 1 NC_004741.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transporter 3783842 yifK 1080109 yifK Shigella flexneri 2a str. 2457T transporter NP_839080.1 3782457 R 198215 CDS NP_839081.1 30064910 1080110 complement(3784033..3784773) 1 NC_004741.1 residues 1 to 246 of 246 are 99.18 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 : B3794; required for synthesis of enterobacterial common antigen (ECA); UDP-N-acetyl-D-mannosaminuronic acid transferase 3784773 wecG 1080110 wecG Shigella flexneri 2a str. 2457T UDP-N-acetyl-D-mannosaminuronic acid transferase NP_839081.1 3784033 R 198215 CDS NP_839082.1 30064911 1080111 complement(3784776..3786128) 1 NC_004741.1 enterobacterial common antigen polymerase; common antigen polymerase 3786128 wecF 1080111 wecF Shigella flexneri 2a str. 2457T common antigen polymerase NP_839082.1 3784776 R 198215 CDS NP_839083.1 30064912 1080112 complement(3786125..3787204) 1 NC_004741.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 3787204 yifM 1080112 yifM Shigella flexneri 2a str. 2457T 4-alpha-L-fucosyltransferase NP_839083.1 3786125 R 198215 CDS NP_839084.1 30064913 1080113 complement(3787201..3788451) 1 NC_004741.1 residues 1 to 416 of 416 are 91.34 pct identical to residues 1 to 416 of 416 from Escherichia coli K-12 : B3792; cytochrome 3788451 wzxE 1080113 wzxE Shigella flexneri 2a str. 2457T cytochrome NP_839084.1 3787201 R 198215 CDS NP_839085.1 30064914 1080114 complement(3788453..3789583) 1 NC_004741.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 3789583 wecE 1080114 wecE Shigella flexneri 2a str. 2457T TDP-4-oxo-6-deoxy-D-glucose transaminase NP_839085.1 3788453 R 198215 CDS NP_839086.1 30064915 1080115 complement(3789588..3790133) 1 NC_004741.1 residues 1 to 181 of 181 are 81.76 pct identical to residues 1 to 181 of 181 from Escherichia coli K-12 : B3790; TDP-fucosamine acetyltransferase 3790133 wecD 1080115 wecD Shigella flexneri 2a str. 2457T TDP-fucosamine acetyltransferase NP_839086.1 3789588 R 198215 CDS NP_839087.1 30064916 1080116 complement(3790240..3791121) 1 NC_004741.1 residues 1 to 293 of 293 are 100.00 pct identical to residues 1 to 293 of 293 from Escherichia coli K-12 : B3789; glucose-1-phosphate thymidylyltransferase 3791121 rffH 1080116 rffH Shigella flexneri 2a str. 2457T glucose-1-phosphate thymidylyltransferase NP_839087.1 3790240 R 198215 CDS NP_839088.1 30064917 1080117 complement(3791140..3792207) 1 NC_004741.1 residues 1 to 355 of 355 are 94.08 pct identical to residues 1 to 355 of 355 from Escherichia coli K-12 : B3788; dTDP-glucose 4,6-dehydratase 3792207 rffG 1080117 rffG Shigella flexneri 2a str. 2457T dTDP-glucose 4,6-dehydratase NP_839088.1 3791140 R 198215 CDS NP_839089.1 30064918 1080118 complement(3792207..3793469) 1 NC_004741.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 3793469 wecC 1080118 wecC Shigella flexneri 2a str. 2457T UDP-N-acetyl-D-mannosamine dehydrogenase NP_839089.1 3792207 R 198215 CDS NP_839090.1 30064919 1080119 complement(3793466..3794638) 1 NC_004741.1 residues 1 to 390 of 390 are 96.15 pct identical to residues 1 to 389 of 389 from Escherichia coli K-12 : B3786; required for synthesis of enterobacterial common antigen (ECA); UDP-N-acetyl glucosamine-2-epimerase 3794638 wecB 1080119 wecB Shigella flexneri 2a str. 2457T UDP-N-acetyl glucosamine-2-epimerase NP_839090.1 3793466 R 198215 CDS NP_839091.1 30064920 1080120 complement(3794652..3795698) 1 NC_004741.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 3795698 wzzE 1080120 wzzE Shigella flexneri 2a str. 2457T lipopolysaccharide biosynthesis protein WzzE NP_839091.1 3794652 R 198215 CDS NP_839092.1 30064921 1080962 complement(3795710..3796813) 1 NC_004741.1 residues 1 to 367 of 367 are 88.82 pct identical to residues 1 to 367 of 367 from Escherichia coli K-12 : B3784; required for synthesis of enterobacterial common antigen (ECA); UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 3796813 rfe 1080962 rfe Shigella flexneri 2a str. 2457T UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase NP_839092.1 3795710 R 198215 CDS NP_839093.1 30064922 1076538 complement(3797053..3798312) 1 NC_004741.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 3798312 rho 1076538 rho Shigella flexneri 2a str. 2457T transcription termination factor Rho NP_839093.1 3797053 R 198215 CDS NP_839094.1 30064923 1080121 complement(3798397..3798498) 1 NC_004741.1 residues 1 to 33 of 33 are 100.00 pct identical to residues 1 to 33 of 33 from Escherichia coli K-12 : B3782; rho operon leader peptide 3798498 rhoL 1080121 rhoL Shigella flexneri 2a str. 2457T rho operon leader peptide NP_839094.1 3798397 R 198215 CDS NP_839095.1 30064924 1080923 complement(3798639..3799022) 1 NC_004741.1 residues 1 to 127 of 127 are 100.00 pct identical to residues 1 to 127 of 127 from Escherichia coli K-12 : B3781; thioredoxin 3799022 trxA 1080923 trxA Shigella flexneri 2a str. 2457T thioredoxin NP_839095.1 3798639 R 198215 CDS NP_839096.1 30064925 1080968 3799099..3800364 1 NC_004741.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 3800364 rhlB 1080968 rhlB Shigella flexneri 2a str. 2457T ATP-dependent RNA helicase RhlB NP_839096.1 3799099 D 198215 CDS NP_839097.1 30064926 1080122 3800498..3801982 1 NC_004741.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 3801982 gppA 1080122 gppA Shigella flexneri 2a str. 2457T guanosine pentaphosphate phosphohydrolase NP_839097.1 3800498 D 198215 CDS NP_839098.1 30064927 1080106 complement(3802029..3804050) 1 NC_004741.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 3804050 rep 1080106 rep Shigella flexneri 2a str. 2457T ATP-dependent DNA helicase Rep NP_839098.1 3802029 R 198215 CDS NP_839099.1 30064928 1080123 3804137..3804418 1 NC_004741.1 residues 1 to 93 of 93 are 98.92 pct identical to residues 1 to 93 of 93 from Escherichia coli K-12 : B3775; peptidyl-prolyl cis-trans isomerase C (rotamase C) 3804418 ppiC 1080123 ppiC Shigella flexneri 2a str. 2457T peptidyl-prolyl cis-trans isomerase C (rotamase C) NP_839099.1 3804137 D 198215 CDS NP_839100.1 30064929 1080124 complement(3804464..3805939) 1 NC_004741.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 3805939 ilvC 1080124 ilvC Shigella flexneri 2a str. 2457T ketol-acid reductoisomerase NP_839100.1 3804464 R 198215 CDS NP_839101.1 30064930 1080125 3806089..3806979 1 NC_004741.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 3806979 ilvY 1080125 ilvY Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator IlvY NP_839101.1 3806089 D 198215 CDS NP_839102.1 30064931 1080126 complement(3806976..3808520) 1 NC_004741.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 3808520 ilvA 1080126 ilvA Shigella flexneri 2a str. 2457T threonine dehydratase NP_839102.1 3806976 R 198215 CDS NP_839103.1 30064932 1080127 complement(3808523..3810373) 1 NC_004741.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 3810373 ilvD 1080127 ilvD Shigella flexneri 2a str. 2457T dihydroxy-acid dehydratase NP_839103.1 3808523 R 198215 CDS NP_839104.1 30064933 1080128 complement(3810438..3811367) 1 NC_004741.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 3811367 ilvE 1080128 ilvE Shigella flexneri 2a str. 2457T branched-chain amino acid aminotransferase NP_839104.1 3810438 R 198215 CDS NP_839105.1 30064934 1080129 complement(3811387..3811647) 1 NC_004741.1 residues 1 to 86 of 86 are 100.00 pct identical to residues 2 to 87 of 87 from Escherichia coli K-12 : B3769; valine insensitive; acetolactate synthase 2 regulatory subunit 3811647 ilvM 1080129 ilvM Shigella flexneri 2a str. 2457T acetolactate synthase 2 regulatory subunit NP_839105.1 3811387 R 198215 CDS NP_839106.1 30064935 1080130 complement(3811647..3813293) 1 NC_004741.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 3813293 ilvG 1080130 ilvG Shigella flexneri 2a str. 2457T acetolactate synthase 2 catalytic subunit NP_839106.1 3811647 R 198215 CDS NP_839107.1 30064936 1080131 complement(3813432..3813530) 1 NC_004741.1 residues 1 to 32 of 32 are 56.25 pct identical to residues 1 to 32 of 32 from Escherichia coli K-12 : B3766; ilvG operon leader peptide 3813530 ilvL 1080131 ilvL Shigella flexneri 2a str. 2457T ilvG operon leader peptide NP_839107.1 3813432 R 198215 CDS NP_839108.1 30064937 1080133 complement(3815386..3815724) 1 NC_004741.1 residues 1 to 112 of 112 are 100.00 pct identical to residues 1 to 112 of 112 from Escherichia coli K-12 : B3764; hypothetical protein 3815724 yifE 1080133 yifE Shigella flexneri 2a str. 2457T hypothetical protein NP_839108.1 3815386 R 198215 CDS NP_839109.1 30064938 1080134 3815843..3816682 1 NC_004741.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 3816682 yifA 1080134 yifA Shigella flexneri 2a str. 2457T transcriptional regulator HdfR NP_839109.1 3815843 D 198215 CDS NP_839110.1 30064939 1080142 3822630..3823178 1 NC_004741.1 residues 1 to 182 of 182 are 98.90 pct identical to residues 1 to 181 of 181 from Escherichia coli K-12 : B3755; hypothetical protein 3823178 yieP 1080142 yieP Shigella flexneri 2a str. 2457T hypothetical protein NP_839110.1 3822630 D 198215 CDS NP_839111.1 30064940 1080144 3823225..3824628 1 NC_004741.1 residues 1 to 467 of 467 are 92.07 pct identical to residues 9 to 475 of 475 from Escherichia coli K-12 : B3754; transporter 3824628 yieO 1080144 yieO Shigella flexneri 2a str. 2457T transporter NP_839111.1 3823225 D 198215 CDS NP_839112.1 30064941 1080145 complement(3824594..3825577) 1 NC_004741.1 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 3825577 rbsR 1080145 rbsR Shigella flexneri 2a str. 2457T transcriptional repressor RbsR NP_839112.1 3824594 R 198215 CDS NP_839113.1 30064942 1080146 complement(3825590..3826534) 1 NC_004741.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 3826534 rbsK 1080146 rbsK Shigella flexneri 2a str. 2457T ribokinase NP_839113.1 3825590 R 198215 CDS NP_839114.1 30064943 1080148 complement(3827560..3828525) 1 NC_004741.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 3828525 rbsC 1080148 rbsC Shigella flexneri 2a str. 2457T ribose ABC transporter permease NP_839114.1 3827560 R 198215 CDS NP_839115.1 30064944 1080149 complement(3829707..3830210) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3830210 1080149 S3936 Shigella flexneri 2a str. 2457T IS1 orfB NP_839115.1 3829707 R 198215 CDS NP_839116.1 30064945 1080150 complement(3830129..3830404) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3830404 1080150 S3937 Shigella flexneri 2a str. 2457T IS1 orfA NP_839116.1 3830129 R 198215 CDS NP_839117.1 30064946 1080152 complement(3830819..3831238) 1 NC_004741.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 3831238 rbsD 1080152 rbsD Shigella flexneri 2a str. 2457T D-ribose pyranase NP_839117.1 3830819 R 198215 CDS NP_839118.1 30064947 1080153 complement(3831405..3833273) 1 NC_004741.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 3833273 trkD 1080153 trkD Shigella flexneri 2a str. 2457T potassium transport protein Kup NP_839118.1 3831405 R 198215 CDS NP_839119.1 30064948 1080154 complement(3833431..3834759) 1 NC_004741.1 residues 1 to 442 of 442 are 100.00 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 3834759 1080154 S3941 Shigella flexneri 2a str. 2457T IS4 orf NP_839119.1 3833431 R 198215 CDS NP_839120.2 229089133 1080155 3834933..3836429 1 NC_004741.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 3836429 yieN 1080155 yieN Shigella flexneri 2a str. 2457T regulatory ATPase RavA NP_839120.2 3834933 D 198215 CDS NP_839121.2 161486402 1080156 3836423..3837874 1 NC_004741.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 3837874 yieM 1080156 yieM Shigella flexneri 2a str. 2457T hypothetical protein NP_839121.2 3836423 D 198215 CDS NP_839122.1 30064951 1080157 complement(3837879..3838871) 1 NC_004741.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 3838871 asnA 1080157 asnA Shigella flexneri 2a str. 2457T asparagine synthetase AsnA NP_839122.1 3837879 R 198215 CDS NP_839123.1 30064952 1080158 3839023..3839481 1 NC_004741.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 3839481 asnC 1080158 asnC Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator AsnC NP_839123.1 3839023 D 198215 CDS NP_839124.1 30064953 1080159 3839571..3840014 1 NC_004741.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 3840014 mioC 1080159 mioC Shigella flexneri 2a str. 2457T flavodoxin NP_839124.1 3839571 D 198215 CDS NP_839125.1 30064954 1080161 3840393..3842282 1 NC_004741.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 3842282 gidA 1080161 gidA Shigella flexneri 2a str. 2457T tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA NP_839125.1 3840393 D 198215 CDS NP_839126.1 30064955 1080162 3842346..3842969 1 NC_004741.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 3842969 gidB 1080162 gidB Shigella flexneri 2a str. 2457T 16S rRNA methyltransferase GidB NP_839126.1 3842346 D 198215 CDS NP_839127.2 161486401 1080163 3843586..3843966 1 NC_004741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 3843966 atpI 1080163 atpI Shigella flexneri 2a str. 2457T F0F1 ATP synthase subunit I NP_839127.2 3843586 D 198215 CDS NP_839128.1 30064957 1080164 3843975..3844790 1 NC_004741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 3844790 atpB 1080164 atpB Shigella flexneri 2a str. 2457T F0F1 ATP synthase subunit A NP_839128.1 3843975 D 198215 CDS NP_839129.1 30064958 1080165 3844837..3845076 1 NC_004741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 3845076 atpE 1080165 atpE Shigella flexneri 2a str. 2457T F0F1 ATP synthase subunit C NP_839129.1 3844837 D 198215 CDS NP_839130.1 30064959 1080166 3845138..3845608 1 NC_004741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 3845608 atpF 1080166 atpF Shigella flexneri 2a str. 2457T F0F1 ATP synthase subunit B NP_839130.1 3845138 D 198215 CDS NP_839131.1 30064960 1080167 3845623..3846156 1 NC_004741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 3846156 atpH 1080167 atpH Shigella flexneri 2a str. 2457T F0F1 ATP synthase subunit delta NP_839131.1 3845623 D 198215 CDS NP_839132.1 30064961 1080168 3846169..3847710 1 NC_004741.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 3847710 atpA 1080168 atpA Shigella flexneri 2a str. 2457T F0F1 ATP synthase subunit alpha NP_839132.1 3846169 D 198215 CDS NP_839133.1 30064962 1080169 3847761..3848624 1 NC_004741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 3848624 atpG 1080169 atpG Shigella flexneri 2a str. 2457T F0F1 ATP synthase subunit gamma NP_839133.1 3847761 D 198215 CDS NP_839134.1 30064963 1080170 3848651..3850033 1 NC_004741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 3850033 atpD 1080170 atpD Shigella flexneri 2a str. 2457T F0F1 ATP synthase subunit beta NP_839134.1 3848651 D 198215 CDS NP_839135.1 30064964 1080171 3850060..3850473 1 NC_004741.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 3850473 atpC 1080171 atpC Shigella flexneri 2a str. 2457T F0F1 ATP synthase subunit epsilon NP_839135.1 3850060 D 198215 CDS NP_839136.1 30064965 1080172 3850824..3852194 1 NC_004741.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 3852194 glmU 1080172 glmU Shigella flexneri 2a str. 2457T bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase NP_839136.1 3850824 D 198215 CDS NP_839137.1 30064966 1080173 3852356..3854185 1 NC_004741.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 3854185 glmS 1080173 glmS Shigella flexneri 2a str. 2457T glucosamine--fructose-6-phosphate aminotransferase NP_839137.1 3852356 D 198215 CDS NP_839138.1 30064967 1080174 3854306..3855634 1 NC_004741.1 residues 1 to 442 of 442 are 99.32 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 3855634 1080174 S3960 Shigella flexneri 2a str. 2457T IS4 orf NP_839138.1 3854306 D 198215 CDS NP_839139.1 30064968 1080175 3855926..3856498 1 NC_004741.1 residues 1 to 190 of 190 are 92.10 pct identical to residues 1 to 190 of 190 from GenPept : >gb|AAL18161.1| (AY057066) LpfA [Escherichia coli]; major fimbrial subunit 3856498 lpfA 1080175 lpfA Shigella flexneri 2a str. 2457T major fimbrial subunit NP_839139.1 3855926 D 198215 CDS NP_839140.2 161486400 1080176 complement(3857264..3858169) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3858169 1080176 S3963 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_839140.2 3857264 R 198215 CDS NP_839141.2 161486399 1080177 complement(3858127..3858492) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3858492 1080177 S3964 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_839141.2 3858127 R 198215 CDS NP_839142.1 30064971 1080178 3860121..3860627 1 NC_004741.1 residues 1 to 168 of 168 are 99.40 pct identical to residues 747 to 914 of 1295 from GenPept : >gb|AAG30168.1|AF289092_1 (AF289092) secreted autotransporter toxin [Escherichia coli]; partial; secreted autotransporter toxin 3860627 1080178 S3965 Shigella flexneri 2a str. 2457T secreted autotransporter toxin NP_839142.1 3860121 D 198215 CDS NP_839143.1 30064972 1080179 complement(3860668..3861381) 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 3861381 1080179 S3966 Shigella flexneri 2a str. 2457T IS600 orfB NP_839143.1 3860668 R 198215 CDS NP_839144.1 30064973 1080959 complement(3861522..3861824) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 3861824 1080959 S3967 Shigella flexneri 2a str. 2457T IS600 orfA NP_839144.1 3861522 R 198215 CDS NP_839145.1 30064974 1080957 3862079..3862372 1 NC_004741.1 residues 1 to 97 of 97 are 87.62 pct identical to residues 24 to 120 of 120 from GenPept : >gb|AAG58857.1|AE005598_1 (AE005598) Z5148 gene product [Escherichia coli O157:H7 EDL933]; transporter 3862372 1080957 S3968 Shigella flexneri 2a str. 2457T transporter NP_839145.1 3862079 D 198215 CDS NP_839146.2 161486398 1080180 complement(3862413..3863603) 1 NC_004741.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter 3863603 nepI 1080180 nepI Shigella flexneri 2a str. 2457T ribonucleoside transporter NP_839146.2 3862413 R 198215 CDS NP_839147.1 30064976 1080181 complement(3863814..3864293) 1 NC_004741.1 residues 1 to 159 of 159 are 98.74 pct identical to residues 1 to 159 of 159 from Escherichia coli K-12 : B3663; hypothetical protein 3864293 yicN 1080181 yicN Shigella flexneri 2a str. 2457T hypothetical protein NP_839147.1 3863814 R 198215 CDS NP_839148.1 30064977 1080183 complement(3864319..3865731) 1 NC_004741.1 residues 1 to 450 of 470 are 96.44 pct identical to residues 1 to 450 of 470 from Escherichia coli K-12 : B3664; hypothetical protein 3865731 yicO 1080183 yicO Shigella flexneri 2a str. 2457T hypothetical protein NP_839148.1 3864319 R 198215 CDS NP_839149.1 30064978 1080184 3865828..3867594 1 NC_004741.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 3867594 yicP 1080184 yicP Shigella flexneri 2a str. 2457T cryptic adenine deaminase NP_839149.1 3865828 D 198215 CDS NP_839150.1 30064979 1080185 complement(3867640..3869031) 1 NC_004741.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 3869031 uhpT 1080185 uhpT Shigella flexneri 2a str. 2457T sugar phosphate antiporter NP_839150.1 3867640 R 198215 CDS NP_839151.1 30064980 1080186 complement(3869169..3870488) 1 NC_004741.1 membrane protein regulates uhpT expression; regulatory protein UhpC 3870488 uhpC 1080186 uhpC Shigella flexneri 2a str. 2457T regulatory protein UhpC NP_839151.1 3869169 R 198215 CDS NP_839152.1 30064981 1080187 complement(3870498..3872000) 1 NC_004741.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 3872000 uhpB 1080187 uhpB Shigella flexneri 2a str. 2457T sensory histidine kinase UhpB NP_839152.1 3870498 R 198215 CDS NP_839153.1 30064982 1080188 complement(3872000..3872590) 1 NC_004741.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA 3872590 uhpA 1080188 uhpA Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator UhpA NP_839153.1 3872000 R 198215 CDS NP_839154.1 30064983 1080190 complement(3872665..3872955) 1 NC_004741.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit 3872955 ilvN 1080190 ilvN Shigella flexneri 2a str. 2457T acetolactate synthase 1 regulatory subunit NP_839154.1 3872665 R 198215 CDS NP_839155.1 30064984 1080191 complement(3872959..3874647) 1 NC_004741.1 catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase catalytic subunit 3874647 ilvB 1080191 ilvB Shigella flexneri 2a str. 2457T acetolactate synthase catalytic subunit NP_839155.1 3872959 R 198215 CDS NP_839156.1 30064985 1080192 complement(3874753..3874851) 1 NC_004741.1 residues 1 to 32 of 32 are 65.62 pct identical to residues 1 to 32 of 32 from Escherichia coli K-12 : B3672; ilvB operon leader peptide 3874851 ivbL 1080192 ivbL Shigella flexneri 2a str. 2457T ilvB operon leader peptide NP_839156.1 3874753 R 198215 CDS NP_839157.1 30064986 1080193 3875818..3876969 1 NC_004741.1 multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 3876969 emrD 1080193 emrD Shigella flexneri 2a str. 2457T multidrug resistance protein D NP_839157.1 3875818 D 198215 CDS NP_839158.1 30064987 1080194 complement(3876977..3877474) 1 NC_004741.1 residues 1 to 165 of 165 are 99.39 pct identical to residues 1 to 165 of 165 from Escherichia coli K-12 : B3674; transcriptional regulator 3877474 yidF 1080194 yidF Shigella flexneri 2a str. 2457T transcriptional regulator NP_839158.1 3876977 R 198215 CDS NP_839159.1 30064988 1080195 complement(3877471..3877833) 1 NC_004741.1 residues 1 to 120 of 120 are 86.66 pct identical to residues 1 to 120 of 120 from Escherichia coli K-12 : B3675; hypothetical protein 3877833 yidG 1080195 yidG Shigella flexneri 2a str. 2457T hypothetical protein NP_839159.1 3877471 R 198215 CDS NP_839160.1 30064989 1080196 complement(3877823..3878170) 1 NC_004741.1 residues 1 to 91 of 115 are 84.61 pct identical to residues 1 to 91 of 115 from Escherichia coli K-12 : B3676; hypothetical protein 3878170 yidH 1080196 yidH Shigella flexneri 2a str. 2457T hypothetical protein NP_839160.1 3877823 R 198215 CDS NP_839161.1 30064990 1080197 3878279..3878692 1 NC_004741.1 residues 1 to 137 of 137 are 70.46 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 : B3677; hypothetical protein 3878692 yidI 1080197 yidI Shigella flexneri 2a str. 2457T hypothetical protein NP_839161.1 3878279 D 198215 CDS NP_839162.1 30064991 1080199 complement(3880216..3881931) 1 NC_004741.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; symporter YidK 3881931 yidK 1080199 yidK Shigella flexneri 2a str. 2457T symporter YidK NP_839162.1 3880216 R 198215 CDS NP_839163.1 30064992 1080200 3882098..3882991 1 NC_004741.1 residues 1 to 297 of 297 are 90.23 pct identical to residues 11 to 307 of 307 from Escherichia coli K-12 : B3680; ARAC-type regulatory protein 3882991 yidL 1080200 yidL Shigella flexneri 2a str. 2457T ARAC-type regulatory protein NP_839163.1 3882098 D 198215 CDS NP_839164.1 30064993 1080202 complement(3883802..3884287) 1 NC_004741.1 residues 1 to 161 of 161 are 100.00 pct identical to residues 1 to 161 of 161 from Escherichia coli K-12 : B3682; arbutin specific enzyme IIB component of PTS 3884287 glvB 1080202 glvB Shigella flexneri 2a str. 2457T arbutin specific enzyme IIB component of PTS NP_839164.1 3883802 R 198215 CDS NP_839165.1 30064994 1080204 3885713..3886387 1 NC_004741.1 residues 1 to 224 of 224 are 99.55 pct identical to residues 1 to 224 of 238 from Escherichia coli K-12 : B3684; transcriptional regulator 3886387 yidP 1080204 yidP Shigella flexneri 2a str. 2457T transcriptional regulator NP_839165.1 3885713 D 198215 CDS NP_839166.1 30064995 1080205 complement(3886426..3888087) 1 NC_004741.1 residues 1 to 553 of 553 are 88.24 pct identical to residues 9 to 561 of 561 from Escherichia coli K-12 : B3685; hypothetical protein 3888087 yidE 1080205 yidE Shigella flexneri 2a str. 2457T hypothetical protein NP_839166.1 3886426 R 198215 CDS NP_839167.1 30064996 1080206 complement(3888283..3888711) 1 NC_004741.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB 3888711 ibpB 1080206 ibpB Shigella flexneri 2a str. 2457T heat shock chaperone IbpB NP_839167.1 3888283 R 198215 CDS NP_839168.1 30064997 1076450 complement(3888823..3889236) 1 NC_004741.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 3889236 ibpA 1076450 ibpA Shigella flexneri 2a str. 2457T heat shock protein IbpA NP_839168.1 3888823 R 198215 CDS NP_839169.2 161486397 1080207 3889541..3889873 1 NC_004741.1 residues 1 to 135 of 135 are 100.00 pct identical to residues 1 to 135 of 135 from Escherichia coli K-12 : B3688; hypothetical protein 3889873 yidQ 1080207 yidQ Shigella flexneri 2a str. 2457T hypothetical protein NP_839169.2 3889541 D 198215 CDS NP_839170.1 30064999 1080208 complement(3889875..3891149) 1 NC_004741.1 residues 1 to 424 of 424 are 94.10 pct identical to residues 1 to 416 of 416 from Escherichia coli K-12 : B3689; hypothetical protein 3891149 yidR 1080208 yidR Shigella flexneri 2a str. 2457T hypothetical protein NP_839170.1 3889875 R 198215 CDS NP_839171.1 30065000 1078769 3891214..3892314 1 NC_004741.1 FAD/NAD(P)-binding domain; oxidoreductase 3892314 yidS 1078769 yidS Shigella flexneri 2a str. 2457T oxidoreductase NP_839171.1 3891214 D 198215 CDS NP_839172.1 30065001 1076998 complement(3892275..3893612) 1 NC_004741.1 residues 1 to 445 of 445 are 97.07 pct identical to residues 1 to 445 of 445 from Escherichia coli K-12 : B3691; D-galactonate transport protein 3893612 dgoT 1076998 dgoT Shigella flexneri 2a str. 2457T D-galactonate transport protein NP_839172.1 3892275 R 198215 CDS NP_839173.1 30065002 1080210 complement(3895433..3896311) 1 NC_004741.1 residues 1 to 292 of 292 are 97.94 pct identical to residues 1 to 292 of 292 from Escherichia coli K-12 : B3693; 2-oxo-3-deoxygalactonate kinase 3896311 dgoK 1080210 dgoK Shigella flexneri 2a str. 2457T 2-oxo-3-deoxygalactonate kinase NP_839173.1 3895433 R 198215 CDS NP_839174.1 30065003 1080211 complement(3896308..3896997) 1 NC_004741.1 residues 17 to 229 of 229 are 25.76 pct identical to residues 22 to 235 of 257 from Escherichia coli K-12 : B4324; regulator protein for dgo operon 3896997 yidW 1080211 yidW Shigella flexneri 2a str. 2457T regulator protein for dgo operon NP_839174.1 3896308 R 198215 CDS NP_839176.1 30065005 1080213 complement(3897977..3898789) 1 NC_004741.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase 3898789 yidA 1080213 yidA Shigella flexneri 2a str. 2457T sugar phosphatase NP_839176.1 3897977 R 198215 CDS NP_839177.1 30065006 1080214 complement(3898903..3899301) 1 NC_004741.1 residues 1 to 132 of 132 are 98.48 pct identical to residues 4 to 135 of 135 from Escherichia coli K-12 : B3698; hypothetical protein 3899301 yidB 1080214 yidB Shigella flexneri 2a str. 2457T hypothetical protein NP_839177.1 3898903 R 198215 CDS NP_839178.1 30065007 1080215 complement(3899541..3901955) 1 NC_004741.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 3901955 gyrB 1080215 gyrB Shigella flexneri 2a str. 2457T DNA gyrase subunit B NP_839178.1 3899541 R 198215 CDS NP_839179.1 30065008 1080216 complement(3901984..3903057) 1 NC_004741.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3903057 recF 1080216 recF Shigella flexneri 2a str. 2457T recombination protein F NP_839179.1 3901984 R 198215 CDS NP_839180.1 30065009 1080217 complement(3903057..3904157) 1 NC_004741.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3904157 dnaN 1080217 dnaN Shigella flexneri 2a str. 2457T DNA polymerase III subunit beta NP_839180.1 3903057 R 198215 CDS NP_839181.1 30065010 1080218 complement(3904162..3905565) 1 NC_004741.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 3905565 dnaA 1080218 dnaA Shigella flexneri 2a str. 2457T chromosomal replication initiation protein NP_839181.1 3904162 R 198215 CDS NP_839182.1 30065011 1080219 3906172..3906312 1 NC_004741.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 3906312 rpmH 1080219 rpmH Shigella flexneri 2a str. 2457T 50S ribosomal protein L34 NP_839182.1 3906172 D 198215 CDS NP_839183.1 30065012 1080220 3906329..3906688 1 NC_004741.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 3906688 rnpA 1080220 rnpA Shigella flexneri 2a str. 2457T ribonuclease P NP_839183.1 3906329 D 198215 CDS NP_839184.1 30065013 1080221 3906912..3908558 1 NC_004741.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 3908558 yidC 1080221 yidC Shigella flexneri 2a str. 2457T inner membrane protein translocase component YidC NP_839184.1 3906912 D 198215 CDS NP_839185.1 30065014 1080222 3908664..3910028 1 NC_004741.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 3910028 trmE 1080222 trmE Shigella flexneri 2a str. 2457T tRNA modification GTPase TrmE NP_839185.1 3908664 D 198215 CDS NP_839186.1 30065015 1080223 complement(3910242..3910745) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3910745 1080223 S4014 Shigella flexneri 2a str. 2457T IS1 orfB NP_839186.1 3910242 R 198215 CDS NP_839187.1 30065016 1080224 complement(3910664..3910939) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3910939 1080224 S4015 Shigella flexneri 2a str. 2457T IS1 orfA NP_839187.1 3910664 R 198215 CDS NP_839188.1 30065017 1080225 3911046..3911120 1 NC_004741.1 residues 1 to 24 of 24 are 95.83 pct identical to residues 1 to 24 of 24 from Escherichia coli K-12 : B3707; tryptophanase leader peptide 3911120 tnaL 1080225 tnaL Shigella flexneri 2a str. 2457T tryptophanase leader peptide NP_839188.1 3911046 D 198215 CDS NP_839189.1 30065018 1080226 3911341..3912756 1 NC_004741.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 3912756 tnaA 1080226 tnaA Shigella flexneri 2a str. 2457T tryptophanase NP_839189.1 3911341 D 198215 CDS NP_839190.1 30065019 1080227 3912847..3914094 1 NC_004741.1 tryptophan transporter of low affinity; tryptophan permease TnaB 3914094 tnaB 1080227 tnaB Shigella flexneri 2a str. 2457T tryptophan permease TnaB NP_839190.1 3912847 D 198215 CDS NP_839191.1 30065020 1080228 3914226..3915401 1 NC_004741.1 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 3915401 yidY 1080228 yidY Shigella flexneri 2a str. 2457T multidrug efflux system protein MdtL NP_839191.1 3914226 D 198215 CDS NP_839192.1 30065021 1080230 complement(3916068..3916781) 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 3916781 1080230 S4021 Shigella flexneri 2a str. 2457T IS600 orfB NP_839192.1 3916068 R 198215 CDS NP_839193.1 30065022 1080231 complement(3916922..3917224) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 3917224 1080231 S4022 Shigella flexneri 2a str. 2457T IS600 orfA NP_839193.1 3916922 R 198215 CDS NP_839194.1 30065023 1080232 3917759..3918508 1 NC_004741.1 residues 1 to 249 of 249 are 98.79 pct identical to residues 5 to 253 of 253 from Escherichia coli K-12 : B3712; hypothetical protein 3918508 yieE 1080232 yieE Shigella flexneri 2a str. 2457T hypothetical protein NP_839194.1 3917759 D 198215 CDS NP_839195.1 30065024 1080233 3918530..3919096 1 NC_004741.1 residues 1 to 188 of 188 are 100.00 pct identical to residues 1 to 188 of 188 from Escherichia coli K-12 : B3713; hypothetical protein 3919096 yieF 1080233 yieF Shigella flexneri 2a str. 2457T hypothetical protein NP_839195.1 3918530 D 198215 CDS NP_839196.1 30065025 1080234 complement(3919150..3920487) 1 NC_004741.1 residues 1 to 445 of 445 are 90.11 pct identical to residues 1 to 445 of 445 from Escherichia coli K-12 : B3714; membrane / transport protein 3920487 yieG 1080234 yieG Shigella flexneri 2a str. 2457T membrane / transport protein NP_839196.1 3919150 R 198215 CDS NP_839197.1 30065026 1080235 3920652..3921308 1 NC_004741.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 3921308 yieH 1080235 yieH Shigella flexneri 2a str. 2457T 6-phosphogluconate phosphatase NP_839197.1 3920652 D 198215 CDS NP_839198.1 30065027 1080236 3921375..3921848 1 NC_004741.1 might be involved in hypersensitivity to nitrofurzone; inner membrane protein 3921848 yieI 1080236 yieI Shigella flexneri 2a str. 2457T inner membrane protein NP_839198.1 3921375 D 198215 CDS NP_839199.1 30065028 1080237 3922016..3922690 1 NC_004741.1 residues 1 to 224 of 224 are 99.55 pct identical to residues 1 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 3922690 1080237 S4029 Shigella flexneri 2a str. 2457T ISSfl3 orfA NP_839199.1 3922016 D 198215 CDS NP_839200.1 30065029 1080238 3922687..3923037 1 NC_004741.1 residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAK18528.1|AF348706_217 (AF348706) IS orf [Shigella flexneri]; partial; ISSfl3 orfB 3923037 1080238 S4030 Shigella flexneri 2a str. 2457T ISSfl3 orfB NP_839200.1 3922687 D 198215 CDS NP_839201.1 30065030 1080239 3923034..3924635 1 NC_004741.1 residues 1 to 533 of 533 are 96.99 pct identical to residues 1 to 533 of 533 from GenPept : >gb|AAL72376.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfC 3924635 1080239 S4031 Shigella flexneri 2a str. 2457T ISSfl3 orfC NP_839201.1 3923034 D 198215 CDS NP_839202.1 30065031 1080241 complement(3925288..3926010) 1 NC_004741.1 residues 24 to 232 of 240 are 93.30 pct identical to residues 1 to 209 of 213 from Escherichia coli K-12 : B3718; 6-phosphogluconolactonase 3926010 yieK 1080241 yieK Shigella flexneri 2a str. 2457T 6-phosphogluconolactonase NP_839202.1 3925288 R 198215 CDS NP_839203.1 30065032 1080242 complement(3926012..3927187) 1 NC_004741.1 residues 1 to 386 of 391 are 93.00 pct identical to residues 12 to 397 of 400 from Escherichia coli K-12 : B3719; xylanase 3927187 yieL 1080242 yieL Shigella flexneri 2a str. 2457T xylanase NP_839203.1 3926012 R 198215 CDS NP_839204.1 30065033 1080243 complement(3927214..3928791) 1 NC_004741.1 residues 1 to 525 of 525 are 96.57 pct identical to residues 14 to 538 of 538 from Escherichia coli K-12 : B3720; receptor protein 3928791 yieC 1080243 yieC Shigella flexneri 2a str. 2457T receptor protein NP_839204.1 3927214 R 198215 CDS NP_839205.1 30065034 1080244 complement(3929306..3929809) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 3929809 1080244 S4036 Shigella flexneri 2a str. 2457T IS1 orfB NP_839205.1 3929306 R 198215 CDS NP_839206.1 30065035 1080245 complement(3929728..3930003) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3930003 1080245 S4037 Shigella flexneri 2a str. 2457T IS1 orfA NP_839206.1 3929728 R 198215 CDS NP_839207.1 30065036 1080246 complement(3930037..3931086) 1 NC_004741.1 residues 1 to 348 of 349 are 97.41 pct identical to residues 1 to 348 of 470 from Escherichia coli K-12 : B3721; phospho-beta-glucosidase B cryptic 3931086 bglB 1080246 bglB Shigella flexneri 2a str. 2457T phospho-beta-glucosidase B cryptic NP_839207.1 3930037 R 198215 CDS NP_839208.1 30065037 1080247 complement(3931105..3932982) 1 NC_004741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; beta-glucoside-specific PTS system components IIABC 3932982 bglF 1080247 bglF Shigella flexneri 2a str. 2457T beta-glucoside-specific PTS system components IIABC NP_839208.1 3931105 R 198215 CDS NP_839209.1 30065038 1080248 complement(3933116..3933937) 1 NC_004741.1 positive regulator of the beta-glucoside operon; transcriptional antiterminator; transcriptional antiterminator BglG 3933937 bglG 1080248 bglG Shigella flexneri 2a str. 2457T transcriptional antiterminator BglG NP_839209.1 3933116 R 198215 CDS NP_839210.1 30065039 1080249 complement(3934224..3934949) 1 NC_004741.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 3934949 phoU 1080249 phoU Shigella flexneri 2a str. 2457T transcriptional regulator PhoU NP_839210.1 3934224 R 198215 CDS NP_839211.1 30065040 1080250 complement(3934964..3935737) 1 NC_004741.1 residues 1 to 257 of 257 are 95.33 pct identical to residues 1 to 257 of 257 from Escherichia coli K-12 : B3725; phosphate transporter subunit 3935737 pstB 1080250 pstB Shigella flexneri 2a str. 2457T phosphate transporter subunit NP_839211.1 3934964 R 198215 CDS NP_839212.1 30065041 1080251 complement(3935829..3936719) 1 NC_004741.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA 3936719 pstA 1080251 pstA Shigella flexneri 2a str. 2457T phosphate transporter permease subunit PtsA NP_839212.1 3935829 R 198215 CDS NP_839213.1 30065042 1080252 complement(3936767..3937678) 1 NC_004741.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC 3937678 pstC 1080252 pstC Shigella flexneri 2a str. 2457T phosphate transporter permease subunit PstC NP_839213.1 3936767 R 198215 CDS NP_839214.1 30065043 1080253 complement(3937765..3938805) 1 NC_004741.1 residues 1 to 346 of 346 are 97.10 pct identical to residues 1 to 346 of 346 from Escherichia coli K-12 : B3728; phosphate ABC transporter substrate-binding protein 3938805 pstS 1080253 pstS Shigella flexneri 2a str. 2457T phosphate ABC transporter substrate-binding protein NP_839214.1 3937765 R 198215 CDS NP_839215.1 30065044 1080254 3940059..3940334 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3940334 1080254 S4046 Shigella flexneri 2a str. 2457T IS1 orfA NP_839215.1 3940059 D 198215 CDS NP_839216.1 30065045 1080255 complement(3940913..3943435) 1 NC_004741.1 residues 1 to 840 of 840 are 99.40 pct identical to residues 1 to 840 of 840 from GenPept : >gb|AAL18163.1| (AY057066) LpfC [Escherichia coli]; long polar fimbriae 3943435 lpfC 1080255 lpfC Shigella flexneri 2a str. 2457T long polar fimbriae NP_839216.1 3940913 R 198215 CDS NP_839217.2 161486396 1080256 3943581..3943946 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3943946 1080256 S4049 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_839217.2 3943581 D 198215 CDS NP_839218.2 161486395 1080257 3943904..3944809 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3944809 1080257 S4050 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_839218.2 3943904 D 198215 CDS NP_839219.1 30065048 1080258 complement(3946459..3948654) 1 NC_004741.1 residues 1 to 731 of 731 are 97.40 pct identical to residues 2 to 732 of 732 from GenPept : >gb|AAD44750.1|AF141323_21 (AF141323) IutA [Shigella flexneri]; ferric siderophore receptor 3948654 iutA 1080258 iutA Shigella flexneri 2a str. 2457T ferric siderophore receptor NP_839219.1 3946459 R 198215 CDS NP_839220.1 30065049 1080259 complement(3948660..3949997) 1 NC_004741.1 residues 1 to 445 of 445 are 100.00 pct identical to residues 1 to 445 of 445 from GenPept : >gb|AAD44749.1|AF141323_20 (AF141323) IucD [Shigella flexneri]; lysine:N6-hydroxylase 3949997 iucD 1080259 iucD Shigella flexneri 2a str. 2457T lysine:N6-hydroxylase NP_839220.1 3948660 R 198215 CDS NP_839221.1 30065050 1080260 complement(3949994..3951736) 1 NC_004741.1 residues 1 to 580 of 580 are 99.48 pct identical to residues 1 to 580 of 580 from GenPept : >gb|AAK71633.1|AF335540_5 (AF335540) IucC [Shigella boydii]; siderophore biosynthesis protein 3951736 iucC 1080260 iucC Shigella flexneri 2a str. 2457T siderophore biosynthesis protein NP_839221.1 3949994 R 198215 CDS NP_839222.1 30065051 1080261 complement(3951736..3952683) 1 NC_004741.1 residues 1 to 315 of 315 are 100.00 pct identical to residues 1 to 315 of 315 from GenPept : >gb|AAK71632.1|AF335540_4 (AF335540) IucB [Shigella boydii]; siderophore biosynthesis protein 3952683 iucB 1080261 iucB Shigella flexneri 2a str. 2457T siderophore biosynthesis protein NP_839222.1 3951736 R 198215 CDS NP_839223.1 30065052 1080262 complement(3952684..3954465) 1 NC_004741.1 residues 1 to 593 of 593 are 100.00 pct identical to residues 1 to 593 of 593 from GenPept : >gb|AAD44746.1|AF141323_17 (AF141323) IucA [Shigella flexneri]; siderophore biosynthesis protein 3954465 iucA 1080262 iucA Shigella flexneri 2a str. 2457T siderophore biosynthesis protein NP_839223.1 3952684 R 198215 CDS NP_839224.1 30065053 1080263 3954544..3955737 1 NC_004741.1 residues 1 to 397 of 397 are 93.19 pct identical to residues 1 to 397 of 397 from GenPept : >gb|AAD44744.1|AF141323_15 (AF141323) ShiF [Shigella flexneri]; membrane transport protein 3955737 imm 1080263 imm Shigella flexneri 2a str. 2457T membrane transport protein NP_839224.1 3954544 D 198215 CDS NP_839225.1 30065054 1080264 complement(3955687..3956658) 1 NC_004741.1 residues 1 to 323 of 323 are 99.68 pct identical to residues 1 to 323 of 323 from NRprotein_Feb03 : >ref|NP_709452.1| orf, partial conserved hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN45159.1|AE015379_1 orf, partial conserved hypothetical protein [Shigella flexneri 2a str. 301]; hypothetical protein 3956658 shiE 1080264 shiE Shigella flexneri 2a str. 2457T hypothetical protein NP_839225.1 3955687 R 198215 CDS NP_839226.1 30065055 1080265 3956539..3956814 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3956814 1080265 S4058 Shigella flexneri 2a str. 2457T IS1 orfA NP_839226.1 3956539 D 198215 CDS NP_839227.1 30065056 1080266 3956733..3957236 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 3957236 1080266 S4059 Shigella flexneri 2a str. 2457T IS1 orfB NP_839227.1 3956733 D 198215 CDS NP_839228.1 30065057 1080267 complement(3957757..3958155) 1 NC_004741.1 residues 1 to 132 of 132 are 100.00 pct identical to residues 1 to 132 of 132 from NRprotein_Feb03 : >ref|NP_709450.1| colicin V immunity protein shiD [imported] [Shigella flexneri 2a str. 301] pir||T44474 colicin V immunity protein shiD [imported] - Shigella flexneri gb|AAD44741.1|AF141323_12 ShiD [Shigella flexneri] gb|AAD54668.1|AF097520_7 novel colicin immunity protein [Shigella flexneri] gb|AA; colV-immunity protein 3958155 shiD 1080267 shiD Shigella flexneri 2a str. 2457T colV-immunity protein NP_839228.1 3957757 R 198215 CDS NP_839229.2 161486394 1080268 3959474..3959839 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3959839 1080268 S4060 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_839229.2 3959474 D 198215 CDS NP_839230.2 161486393 1080269 3959797..3960702 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3960702 1080269 S4061 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_839230.2 3959797 D 198215 CDS NP_839231.1 30065060 1080270 3961705..3962031 1 NC_004741.1 residues 1 to 108 of 108 are 74.07 pct identical to residues 1 to 108 of 108 from GenPept : >emb|CAA35935.1| (X51586) unknown peptide (AA 1-108) [Shigella sonnei]; IS629 orfA 3962031 1080270 S4062 Shigella flexneri 2a str. 2457T IS629 orfA NP_839231.1 3961705 D 198215 CDS NP_839232.1 30065061 1080271 3962267..3962914 1 NC_004741.1 residues 1 to 215 of 215 are 99.53 pct identical to residues 8 to 222 of 222 from GenPept : >gb|AAL72361.1| (AF386526) transposase [Shigella flexneri 2a]; IS629 orfB 3962914 1080271 S4063 Shigella flexneri 2a str. 2457T IS629 orfB NP_839232.1 3962267 D 198215 CDS NP_839233.1 30065062 1080272 complement(3962995..3963513) 1 NC_004741.1 residues 1 to 172 of 172 are 100.00 pct identical to residues 1 to 172 of 172 from NRprotein_Feb03 : >pir||T44468 hypothetical protein shiC [imported] - Shigella flexneri gb|AAD44735.1|AF141323_6 ShiC [Shigella flexneri] gb|AAD54667.1|AF097520_5 unknown [Shigella flexneri]; hypothetical protein 3963513 shiC 1080272 shiC Shigella flexneri 2a str. 2457T hypothetical protein NP_839233.1 3962995 R 198215 CDS NP_839234.1 30065063 1080273 3963698..3963997 1 NC_004741.1 residues 1 to 99 of 99 are 74.74 pct identical to residues 4 to 102 of 102 from GenPept : >gb|AAK18485.1|AF348706_174 (AF348706) orf, hypothetical [Shigella flexneri]; IS3 orfA 3963997 1080273 S4064 Shigella flexneri 2a str. 2457T IS3 orfA NP_839234.1 3963698 D 198215 CDS NP_839235.1 30065064 1080274 3963994..3964386 1 NC_004741.1 residues 1 to 130 of 130 are 100.00 pct identical to residues 1 to 130 of 130 from NRprotein_Feb03 : >ref|NP_709441.1| transposase tnpB [imported] [Shigella flexneri 2a str. 301] pir||T44467 transposase tnpB [imported] - Shigella flexneri gb|AAD44734.1|AF141323_5 TnpB [Shigella flexneri] gb|AAN45148.1|AE015378_3 transposase tnpB [imported] [Shigella flexneri 2a str. 301]; IS3 orfB 3964386 1080274 S4832 Shigella flexneri 2a str. 2457T IS3 orfB NP_839235.1 3963994 D 198215 CDS NP_839236.1 30065065 1080275 complement(3964845..3965306) 1 NC_004741.1 residues 1 to 153 of 153 are 99.34 pct identical to residues 1 to 153 of 153 from NRprotein_Feb03 : >pir||T44465 hypothetical protein shiB [imported] - Shigella flexneri gb|AAD44732.1|AF141323_3 ShiB [Shigella flexneri]; hypothetical protein 3965306 shiB 1080275 shiB Shigella flexneri 2a str. 2457T hypothetical protein NP_839236.1 3964845 R 198215 CDS NP_839237.1 30065066 1080276 complement(3965821..3966864) 1 NC_004741.1 residues 1 to 347 of 347 are 100.00 pct identical to residues 1 to 347 of 347 from NRprotein_Feb03 : >ref|NP_709438.1| orf, conserved hypothetical protein [Shigella flexneri 2a str. 301] pir||T44464 hypothetical protein shiA [imported] - Shigella flexneri gb|AAD44731.1|AF141323_2 ShiA [Shigella flexneri] gb|AAN45145.1|AE015377_5 orf, conserved hypothetical protein [Shigella flexneri 2a str. 301]; hypothetical protein 3966864 shiA 1080276 shiA Shigella flexneri 2a str. 2457T hypothetical protein NP_839237.1 3965821 R 198215 CDS NP_839238.1 30065067 1080277 complement(3967276..3968487) 1 NC_004741.1 residues 1 to 403 of 403 are 100.00 pct identical to residues 1 to 403 of 403 from NRprotein_Feb03 : >ref|NP_709437.1| Sai integrase [Shigella flexneri 2a str. 301] gb|AAD54663.1|AF097520_1 Sai integrase [Shigella flexneri] gb|AAN45144.1|AE015377_4 Sai integrase [Shigella flexneri 2a str. 301]; integrase 3968487 1080277 S4835 Shigella flexneri 2a str. 2457T integrase NP_839238.1 3967276 R 198215 CDS NP_839239.1 30065068 1080280 3970539..3972857 1 NC_004741.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase 3972857 yicI 1080280 yicI Shigella flexneri 2a str. 2457T alpha-xylosidase NP_839239.1 3970539 D 198215 CDS NP_839240.1 30065069 1080281 complement(3972910..3974619) 1 NC_004741.1 residues 24 to 569 of 569 are 99.08 pct identical to residues 24 to 569 of 569 from Escherichia coli K-12 : B3655; hypothetical protein 3974619 yicH 1080281 yicH Shigella flexneri 2a str. 2457T hypothetical protein NP_839240.1 3972910 R 198215 CDS NP_839241.1 30065070 1080282 complement(3974740..3976131) 1 NC_004741.1 residues 1 to 463 of 463 are 96.97 pct identical to residues 1 to 463 of 463 from Escherichia coli K-12 : B3654; transporter 3976131 yicE 1080282 yicE Shigella flexneri 2a str. 2457T transporter NP_839241.1 3974740 R 198215 CDS NP_839242.1 30065071 1080283 3976411..3977616 1 NC_004741.1 residues 1 to 401 of 401 are 82.54 pct identical to residues 1 to 401 of 401 from Escherichia coli K-12 : B3653; glutamate transport protein 3977616 gltS 1080283 gltS Shigella flexneri 2a str. 2457T glutamate transport protein NP_839242.1 3976411 D 198215 CDS NP_839243.1 30065072 1080284 complement(3977650..3979731) 1 NC_004741.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 3979731 recG 1080284 recG Shigella flexneri 2a str. 2457T ATP-dependent DNA helicase RecG NP_839243.1 3977650 R 198215 CDS NP_839244.1 30065073 1080285 complement(3979737..3980426) 1 NC_004741.1 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 3980426 spoU 1080285 spoU Shigella flexneri 2a str. 2457T tRNA guanosine-2'-O-methyltransferase NP_839244.1 3979737 R 198215 CDS NP_839245.1 30065074 1080286 complement(3980433..3982541) 1 NC_004741.1 residues 1 to 702 of 702 are 98.14 pct identical to residues 1 to 702 of 702 from Escherichia coli K-12 : B3650; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 3982541 spoT 1080286 spoT Shigella flexneri 2a str. 2457T bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase NP_839245.1 3980433 R 198215 CDS NP_839246.1 30065075 1080287 complement(3982560..3982835) 1 NC_004741.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 3982835 rpoZ 1080287 rpoZ Shigella flexneri 2a str. 2457T DNA-directed RNA polymerase subunit omega NP_839246.1 3982560 R 198215 CDS NP_839247.1 30065076 1080288 complement(3982890..3983513) 1 NC_004741.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 3983513 gmk 1080288 gmk Shigella flexneri 2a str. 2457T guanylate kinase NP_839247.1 3982890 R 198215 CDS NP_839248.1 30065077 1080289 3983771..3985453 1 NC_004741.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 3985453 ligB 1080289 ligB Shigella flexneri 2a str. 2457T NAD-dependent DNA ligase LigB NP_839248.1 3983771 D 198215 CDS NP_839249.1 30065078 1080290 complement(3985450..3986121) 1 NC_004741.1 residues 1 to 223 of 223 are 73.54 pct identical to residues 1 to 223 of 223 from Escherichia coli K-12 : B3646; hypothetical protein 3986121 yicG 1080290 yicG Shigella flexneri 2a str. 2457T hypothetical protein NP_839249.1 3985450 R 198215 CDS NP_839250.1 30065079 1080291 complement(3986358..3987182) 1 NC_004741.1 residues 1 to 274 of 274 are 97.81 pct identical to residues 5 to 278 of 278 from Escherichia coli K-12 : B3645; DNA-damage-inducible protein D 3987182 dinD 1080291 dinD Shigella flexneri 2a str. 2457T DNA-damage-inducible protein D NP_839250.1 3986358 R 198215 CDS NP_839251.1 30065080 1080292 complement(3987403..3988266) 1 NC_004741.1 residues 1 to 287 of 287 are 94.42 pct identical to residues 1 to 287 of 287 from Escherichia coli K-12 : B3644; hypothetical protein 3988266 yicC 1080292 yicC Shigella flexneri 2a str. 2457T hypothetical protein NP_839251.1 3987403 R 198215 CDS NP_839252.1 30065081 1080293 3988393..3989109 1 NC_004741.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 3989109 rph 1080293 rph Shigella flexneri 2a str. 2457T ribonuclease PH NP_839252.1 3988393 D 198215 CDS NP_839253.1 30065082 1080294 3989175..3989816 1 NC_004741.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 3989816 pyrE 1080294 pyrE Shigella flexneri 2a str. 2457T orotate phosphoribosyltransferase NP_839253.1 3989175 D 198215 CDS NP_839254.2 161486392 1080295 complement(3989853..3990449) 1 NC_004741.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 3990449 slmA 1080295 slmA Shigella flexneri 2a str. 2457T nucleoid occlusion protein NP_839254.2 3989853 R 198215 CDS NP_839255.1 30065084 1080296 complement(3990556..3991014) 1 NC_004741.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 3991014 dut 1080296 dut Shigella flexneri 2a str. 2457T deoxyuridine 5'-triphosphate nucleotidohydrolase NP_839255.1 3990556 R 198215 CDS NP_839256.2 161486391 1080297 complement(3990992..3992212) 1 NC_004741.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 3992212 dfp 1080297 dfp Shigella flexneri 2a str. 2457T bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase NP_839256.2 3990992 R 198215 CDS NP_839257.2 161486390 1080298 3992378..3993052 1 NC_004741.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 3993052 radC 1080298 radC Shigella flexneri 2a str. 2457T DNA repair protein RadC NP_839257.2 3992378 D 198215 CDS NP_839258.1 30065087 1080299 3993269..3993505 1 NC_004741.1 required for 70S ribosome assembly; 50S ribosomal protein L28 3993505 rpmB 1080299 rpmB Shigella flexneri 2a str. 2457T 50S ribosomal protein L28 NP_839258.1 3993269 D 198215 CDS NP_839259.1 30065088 1080300 3993526..3993693 1 NC_004741.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 3993693 rpmG 1080300 rpmG Shigella flexneri 2a str. 2457T 50S ribosomal protein L33 NP_839259.1 3993526 D 198215 CDS NP_839260.1 30065089 1080301 3993791..3994600 1 NC_004741.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 3994600 mutM 1080301 mutM Shigella flexneri 2a str. 2457T formamidopyrimidine-DNA glycosylase NP_839260.1 3993791 D 198215 CDS NP_839261.1 30065090 1080302 complement(3994639..3995118) 1 NC_004741.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 3995118 coaD 1080302 coaD Shigella flexneri 2a str. 2457T phosphopantetheine adenylyltransferase NP_839261.1 3994639 R 198215 CDS NP_839262.1 30065091 1080303 complement(3995126..3996403) 1 NC_004741.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 3996403 kdtA 1080303 kdtA Shigella flexneri 2a str. 2457T 3-deoxy-D-manno-octulosonic-acid transferase NP_839262.1 3995126 R 198215 CDS NP_839263.1 30065092 1080304 3996537..3996812 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 3996812 1080304 S4097 Shigella flexneri 2a str. 2457T IS1 orfA NP_839263.1 3996537 D 198215 CDS NP_839264.1 30065093 1080305 3996731..3997234 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 3997234 1080305 S4098 Shigella flexneri 2a str. 2457T IS1 orfB NP_839264.1 3996731 D 198215 CDS NP_839265.1 30065094 1080306 3997592..3998650 1 NC_004741.1 residues 1 to 352 of 352 are 96.59 pct identical to residues 1 to 352 of 352 from GenPept : >gb|AAG58776.1|AE005590_11 (AE005590) LPS biosynthesis enzyme [Escherichia coli O157:H7 EDL933]; lipopolysaccharide core biosynthesis protein 3998650 waaQ 1080306 waaQ Shigella flexneri 2a str. 2457T lipopolysaccharide core biosynthesis protein NP_839265.1 3997592 D 198215 CDS NP_839266.1 30065095 1080307 3998647..3999771 1 NC_004741.1 residues 1 to 374 of 374 are 99.46 pct identical to residues 1 to 374 of 374 from GenPept : >gb|AAC69678.1| (AF019746) UDP-glucose:(heptosyl) LPS alpha1,3-glucosyltransferase WaaG [Escherichia coli]; LPS alpha1,3-glucosyltransferase 3999771 waaG 1080307 waaG Shigella flexneri 2a str. 2457T LPS alpha1,3-glucosyltransferase NP_839266.1 3998647 D 198215 CDS NP_839267.1 30065096 1080308 3999755..4000561 1 NC_004741.1 residues 1 to 268 of 268 are 93.65 pct identical to residues 1 to 268 of 268 from GenPept : >gb|AAG58774.1|AE005590_9 (AE005590) LPS biosynthesis enzyme [Escherichia coli O157:H7 EDL933]; lipopolysaccharide core biosynthesis protein 4000561 waaP 1080308 waaP Shigella flexneri 2a str. 2457T lipopolysaccharide core biosynthesis protein NP_839267.1 3999755 D 198215 CDS NP_839268.1 30065097 1080309 4000604..4001611 1 NC_004741.1 residues 1 to 335 of 335 are 99.70 pct identical to residues 1 to 335 of 335 from GenPept : >gb|AAG58773.1|AE005590_8 (AE005590) LPS biosynthesis enzyme [Escherichia coli O157:H7 EDL933]; UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase 4001611 waaL 1080309 waaL Shigella flexneri 2a str. 2457T UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase NP_839268.1 4000604 D 198215 CDS NP_839269.1 30065098 1080310 4001637..4002344 1 NC_004741.1 residues 1 to 235 of 235 are 93.19 pct identical to residues 1 to 235 of 235 from GenPept : >gb|AAC69664.1| (AF019745) WaaY [Escherichia coli]; lipopolysaccharide core biosynthesis protein 4002344 waaY 1080310 waaY Shigella flexneri 2a str. 2457T lipopolysaccharide core biosynthesis protein NP_839269.1 4001637 D 198215 CDS NP_839270.1 30065099 1080311 4002369..4003382 1 NC_004741.1 residues 1 to 337 of 337 are 94.06 pct identical to residues 1 to 337 of 337 from GenPept : >gb|AAG58771.1|AE005590_6 (AE005590) LPS biosynthesis enzyme [Escherichia coli O157:H7 EDL933]; UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase 4003382 waaJ 1080311 waaJ Shigella flexneri 2a str. 2457T UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase NP_839270.1 4002369 D 198215 CDS NP_839271.1 30065100 1080312 4003391..4004533 1 NC_004741.1 residues 1 to 380 of 380 are 96.31 pct identical to residues 1 to 380 of 380 from GenPept : >gb|AAG58770.1|AE005590_5 (AE005590) LPS biosynthesis enzyme [Escherichia coli O157:H7 EDL933]; lipopolysaccharide 1,2-N- acetylglucosaminetransferase 4004533 waaD 1080312 waaD Shigella flexneri 2a str. 2457T lipopolysaccharide 1,2-N- acetylglucosaminetransferase NP_839271.1 4003391 D 198215 CDS NP_839272.1 30065101 1080189 complement(4004569..4005777) 1 NC_004741.1 residues 1 to 402 of 402 are 93.28 pct identical to residues 1 to 402 of 402 from GenPept : >gb|AAG58769.1|AE005590_4 (AE005590) LPS biosynthesis enzyme [Escherichia coli O157:H7 EDL933]; lipid A-core, surface polymer ligase 4005777 waaI 1080189 waaI Shigella flexneri 2a str. 2457T lipid A-core, surface polymer ligase NP_839272.1 4004569 R 198215 CDS NP_839273.1 30065102 1080313 complement(4005774..4006736) 1 NC_004741.1 residues 1 to 307 of 320 are 94.13 pct identical to residues 11 to 317 of 319 from Escherichia coli K-12 : B3621; involved in lipopolysaccharide core biosynthesis; ADP-heptose--LPS heptosyltransferase 4006736 rfaC 1080313 rfaC Shigella flexneri 2a str. 2457T ADP-heptose--LPS heptosyltransferase NP_839273.1 4005774 R 198215 CDS NP_839274.1 30065103 1080314 complement(4006770..4007816) 1 NC_004741.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose--LPS heptosyltransferase 4007816 rfaF 1080314 rfaF Shigella flexneri 2a str. 2457T ADP-heptose--LPS heptosyltransferase NP_839274.1 4006770 R 198215 CDS NP_839275.1 30065104 1080315 complement(4007826..4008758) 1 NC_004741.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 4008758 rfaD 1080315 rfaD Shigella flexneri 2a str. 2457T ADP-L-glycero-D-manno-heptose-6-epimerase NP_839275.1 4007826 R 198215 CDS NP_839276.1 30065105 1080316 4010194..4011390 1 NC_004741.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 4011390 kbl 1080316 kbl Shigella flexneri 2a str. 2457T 2-amino-3-ketobutyrate coenzyme A ligase NP_839276.1 4010194 D 198215 CDS NP_839277.1 30065106 1080317 4011400..4012425 1 NC_004741.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 4012425 tdh 1080317 tdh Shigella flexneri 2a str. 2457T L-threonine 3-dehydrogenase NP_839277.1 4011400 D 198215 CDS NP_839278.1 30065107 1080939 4012655..4012930 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4012930 1080939 S4112 Shigella flexneri 2a str. 2457T IS1 orfA NP_839278.1 4012655 D 198215 CDS NP_839279.1 30065108 1079655 4012849..4013352 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4013352 1079655 S4113 Shigella flexneri 2a str. 2457T IS1 orfB NP_839279.1 4012849 D 198215 CDS NP_839280.1 30065109 1080318 4013434..4013574 1 NC_004741.1 residues 1 to 46 of 46 are 100.00 pct identical to residues 299 to 344 of 344 from Escherichia coli K-12 : B3615; regulator 4013574 yibD 1080318 yibD Shigella flexneri 2a str. 2457T regulator NP_839280.1 4013434 D 198215 CDS NP_839281.1 30065110 1080319 complement(4013561..4014394) 1 NC_004741.1 residues 1 to 277 of 277 are 99.63 pct identical to residues 1 to 277 of 277 from Escherichia coli K-12 : B3614; hypothetical protein 4014394 yibQ 1080319 yibQ Shigella flexneri 2a str. 2457T hypothetical protein NP_839281.1 4013561 R 198215 CDS NP_839282.2 161486389 1080320 complement(4014524..4015807) 1 NC_004741.1 residues 1 to 419 of 419 are 92.84 pct identical to residues 9 to 427 of 427 from Escherichia coli K-12 : B3613; hypothetical protein 4015807 yibP 1080320 yibP Shigella flexneri 2a str. 2457T hypothetical protein NP_839282.2 4014524 R 198215 CDS NP_839283.1 30065112 1080321 complement(4015817..4017361) 1 NC_004741.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4017361 yibO 1080321 yibO Shigella flexneri 2a str. 2457T phosphoglyceromutase NP_839283.1 4015817 R 198215 CDS NP_839284.1 30065113 1080322 4017606..4018037 1 NC_004741.1 residues 1 to 143 of 143 are 99.30 pct identical to residues 1 to 143 of 143 from Escherichia coli K-12 : B3611; hypothetical protein 4018037 yibN 1080322 yibN Shigella flexneri 2a str. 2457T hypothetical protein NP_839284.1 4017606 D 198215 CDS NP_839285.1 30065114 1080323 4018179..4018430 1 NC_004741.1 residues 1 to 83 of 83 are 98.79 pct identical to residues 1 to 83 of 83 from Escherichia coli K-12 : B3610; glutaredoxin 3 4018430 grxC 1080323 grxC Shigella flexneri 2a str. 2457T glutaredoxin 3 NP_839285.1 4018179 D 198215 CDS NP_839286.1 30065115 1080324 4018493..4018960 1 NC_004741.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 4018960 secB 1080324 secB Shigella flexneri 2a str. 2457T preprotein translocase subunit SecB NP_839286.1 4018493 D 198215 CDS NP_839287.1 30065116 1080325 4018960..4019979 1 NC_004741.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 4019979 gpsA 1080325 gpsA Shigella flexneri 2a str. 2457T NAD(P)H-dependent glycerol-3-phosphate dehydrogenase NP_839287.1 4018960 D 198215 CDS NP_839288.1 30065117 1080326 4020059..4020880 1 NC_004741.1 catalyzes the O-acetylation of serine; serine acetyltransferase 4020880 cysE 1080326 cysE Shigella flexneri 2a str. 2457T serine acetyltransferase NP_839288.1 4020059 D 198215 CDS NP_839289.1 30065118 1080327 complement(4020933..4021406) 1 NC_004741.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 4021406 yibK 1080327 yibK Shigella flexneri 2a str. 2457T tRNA/rRNA methyltransferase YibK NP_839289.1 4020933 R 198215 CDS NP_839290.1 30065119 1078229 complement(4021602..4022792) 1 NC_004741.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4022792 lldD 1078229 lldD Shigella flexneri 2a str. 2457T L-lactate dehydrogenase NP_839290.1 4021602 R 198215 CDS NP_839291.1 30065120 1080328 complement(4022789..4023565) 1 NC_004741.1 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4023565 lldR 1080328 lldR Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor LldR NP_839291.1 4022789 R 198215 CDS NP_839292.1 30065121 1080329 complement(4023565..4025220) 1 NC_004741.1 residues 1 to 551 of 551 are 84.93 pct identical to residues 1 to 551 of 551 from Escherichia coli K-12 : B3603; L-lactate permease 4025220 lldP 1080329 lldP Shigella flexneri 2a str. 2457T L-lactate permease NP_839292.1 4023565 R 198215 CDS NP_839293.1 30065122 1080331 4031481..4031756 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4031756 1080331 S4130 Shigella flexneri 2a str. 2457T IS1 orfA NP_839293.1 4031481 D 198215 CDS NP_839294.1 30065123 1080332 4031675..4032178 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4032178 1080332 S4131 Shigella flexneri 2a str. 2457T IS1 orfB NP_839294.1 4031675 D 198215 CDS NP_839295.1 30065124 1080333 complement(4032297..4032659) 1 NC_004741.1 residues 1 to 120 of 120 are 85.83 pct identical to residues 1 to 120 of 120 from Escherichia coli K-12 : B3602; hypothetical protein 4032659 yibL 1080333 yibL Shigella flexneri 2a str. 2457T hypothetical protein NP_839295.1 4032297 R 198215 CDS NP_839296.1 30065125 1080334 complement(4033164..4033751) 1 NC_004741.1 Acts as a repressor of the mtlAD operon; mannitol repressor protein 4033751 mtlR 1080334 mtlR Shigella flexneri 2a str. 2457T mannitol repressor protein NP_839296.1 4033164 R 198215 CDS NP_839297.1 30065126 1080335 complement(4033751..4034899) 1 NC_004741.1 residues 1 to 382 of 382 are 98.95 pct identical to residues 1 to 382 of 382 from Escherichia coli K-12 : B3600; mannitol-1-phosphate 5-dehydrogenase 4034899 mtlD 1080335 mtlD Shigella flexneri 2a str. 2457T mannitol-1-phosphate 5-dehydrogenase NP_839297.1 4033751 R 198215 CDS NP_839298.1 30065127 1080336 complement(4034994..4036907) 1 NC_004741.1 residues 1 to 637 of 637 are 90.42 pct identical to residues 1 to 637 of 637 from Escherichia coli K-12 : B3599; PTS system, mannitol-specific enzyme IIABC components 4036907 mtlA 1080336 mtlA Shigella flexneri 2a str. 2457T PTS system, mannitol-specific enzyme IIABC components NP_839298.1 4034994 R 198215 CDS NP_839299.1 30065128 1080337 4037444..4037806 1 NC_004741.1 residues 1 to 120 of 120 are 99.16 pct identical to residues 1 to 120 of 120 from Escherichia coli K-12 : B3598; hypothetical protein 4037806 yibI 1080337 yibI Shigella flexneri 2a str. 2457T hypothetical protein NP_839299.1 4037444 D 198215 CDS NP_839300.1 30065129 1080338 4037809..4038894 1 NC_004741.1 residues 24 to 361 of 361 are 100.00 pct identical to residues 41 to 378 of 378 from Escherichia coli K-12 : B3597; hypothetical protein 4038894 yibH 1080338 yibH Shigella flexneri 2a str. 2457T hypothetical protein NP_839300.1 4037809 D 198215 CDS NP_839301.1 30065130 1080339 4038965..4039573 1 NC_004741.1 residues 1 to 202 of 202 are 99.50 pct identical to residues 1 to 202 of 202 from Escherichia coli K-12 : B3592; glutathione S-transferase 4039573 yibF 1080339 yibF Shigella flexneri 2a str. 2457T glutathione S-transferase NP_839301.1 4038965 D 198215 CDS NP_839302.1 30065131 1080340 4039671..4041062 1 NC_004741.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 4041062 selA 1080340 selA Shigella flexneri 2a str. 2457T selenocysteine synthase NP_839302.1 4039671 D 198215 CDS NP_839303.1 30065132 1080341 4041059..4042903 1 NC_004741.1 residues 1 to 614 of 614 are 98.37 pct identical to residues 1 to 614 of 614 from Escherichia coli K-12 : B3590; selenocysteinyl-tRNA-specific translation factor 4042903 selB 1080341 selB Shigella flexneri 2a str. 2457T selenocysteinyl-tRNA-specific translation factor NP_839303.1 4041059 D 198215 CDS NP_839304.1 30065133 1080342 4043093..4044244 1 NC_004741.1 residues 1 to 381 of 383 are 96.06 pct identical to residues 1 to 381 of 382 from Escherichia coli K-12 : B3589; alcohol dehydrogenase 4044244 yiaY 1080342 yiaY Shigella flexneri 2a str. 2457T alcohol dehydrogenase NP_839304.1 4043093 D 198215 CDS NP_839305.1 30065134 1080343 4044319..4045947 1 NC_004741.1 residues 1 to 542 of 542 are 96.30 pct identical to residues 1 to 542 of 542 from Escherichia coli K-12 : B3588; aldehyde dehydrogenase B (lactaldehyde dehydrogenase) 4045947 aldB 1080343 aldB Shigella flexneri 2a str. 2457T aldehyde dehydrogenase B (lactaldehyde dehydrogenase) NP_839305.1 4044319 D 198215 CDS NP_839306.1 30065135 1080344 complement(4046643..4047146) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 4047146 1080344 S4143 Shigella flexneri 2a str. 2457T IS1 orfB NP_839306.1 4046643 R 198215 CDS NP_839307.1 30065136 1080345 complement(4047065..4047340) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4047340 1080345 S4144 Shigella flexneri 2a str. 2457T IS1 orfA NP_839307.1 4047065 R 198215 CDS NP_839308.1 30065137 1080346 complement(4047374..4048666) 1 NC_004741.1 residues 27 to 390 of 430 are 83.51 pct identical to residues 27 to 390 of 424 from Escherichia coli K-12 : B3578; hypothetical protein 4048666 1080346 S4145 Shigella flexneri 2a str. 2457T hypothetical protein NP_839308.1 4047374 R 198215 CDS NP_839309.1 30065138 1079322 complement(4049001..4049504) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 4049504 1079322 S4147 Shigella flexneri 2a str. 2457T IS1 orfB NP_839309.1 4049001 R 198215 CDS NP_839310.1 30065139 1080347 complement(4049423..4049698) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAA96691.1| (M37616) insA gene product [Insertion sequence IS1]; IS1 orfA 4049698 1080347 S4148 Shigella flexneri 2a str. 2457T IS1 orfA NP_839310.1 4049423 R 198215 CDS NP_839311.1 30065140 1080353 complement(4049913..4050911) 1 NC_004741.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 4050911 yiaK 1080353 yiaK Shigella flexneri 2a str. 2457T 2,3-diketo-L-gulonate reductase NP_839311.1 4049913 R 198215 CDS NP_839312.1 30065141 1080355 4051111..4051959 1 NC_004741.1 residues 1 to 282 of 282 are 99.64 pct identical to residues 1 to 282 of 282 from Escherichia coli K-12 : B3574; regulator 4051959 yiaJ 1080355 yiaJ Shigella flexneri 2a str. 2457T regulator NP_839312.1 4051111 D 198215 CDS NP_839313.1 30065142 1080357 4052061..4052534 1 NC_004741.1 residues 1 to 157 of 157 are 97.45 pct identical to residues 1 to 157 of 157 from Escherichia coli K-12 : B3573; hypothetical protein 4052534 yiaI 1080357 yiaI Shigella flexneri 2a str. 2457T hypothetical protein NP_839313.1 4052061 D 198215 CDS NP_839314.1 30065143 1080358 complement(4052685..4053938) 1 NC_004741.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 4053938 avtA 1080358 avtA Shigella flexneri 2a str. 2457T valine--pyruvate transaminase NP_839314.1 4052685 R 198215 CDS NP_839315.1 30065144 1080359 complement(4054116..4056146) 1 NC_004741.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase precursor 4056146 malS 1080359 malS Shigella flexneri 2a str. 2457T periplasmic alpha-amylase precursor NP_839315.1 4054116 R 198215 CDS NP_839316.1 30065145 1080360 4056466..4057290 1 NC_004741.1 residues 1 to 274 of 274 are 99.27 pct identical to residues 1 to 274 of 274 from Escherichia coli K-12 : B3570; hypothetical protein 4057290 bax 1080360 bax Shigella flexneri 2a str. 2457T hypothetical protein NP_839316.1 4056466 D 198215 CDS NP_839317.1 30065146 1080362 complement(4058654..4059835) 1 NC_004741.1 residues 1 to 393 of 393 are 81.67 pct identical to residues 1 to 393 of 393 from Escherichia coli K-12 : B3568; xylose transporter membrane component 4059835 xylH 1080362 xylH Shigella flexneri 2a str. 2457T xylose transporter membrane component NP_839317.1 4058654 R 198215 CDS NP_839318.1 30065147 1080363 complement(4059813..4061354) 1 NC_004741.1 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 4061354 xylG 1080363 xylG Shigella flexneri 2a str. 2457T xylose transporter ATP-binding subunit NP_839318.1 4059813 R 198215 CDS NP_839319.1 30065148 1080364 complement(4061432..4062424) 1 NC_004741.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 4062424 xylF 1080364 xylF Shigella flexneri 2a str. 2457T D-xylose transporter subunit XylF NP_839319.1 4061432 R 198215 CDS NP_839320.1 30065149 1080366 4064184..4065638 1 NC_004741.1 residues 1 to 484 of 484 are 89.46 pct identical to residues 1 to 484 of 484 from Escherichia coli K-12 : B3564; xylulokinase 4065638 xylB 1080366 xylB Shigella flexneri 2a str. 2457T xylulokinase NP_839320.1 4064184 D 198215 CDS NP_839321.1 30065150 1080367 4065807..4066148 1 NC_004741.1 residues 1 to 112 of 113 are 98.21 pct identical to residues 5 to 116 of 117 from Escherichia coli K-12 : B3563; hypothetical protein 4066148 yiaB 1080367 yiaB Shigella flexneri 2a str. 2457T hypothetical protein NP_839321.1 4065807 D 198215 CDS NP_839322.1 30065151 1080368 4066194..4066631 1 NC_004741.1 residues 1 to 145 of 145 are 100.00 pct identical to residues 2 to 146 of 146 from Escherichia coli K-12 : B3562; hypothetical protein 4066631 yiaA 1080368 yiaA Shigella flexneri 2a str. 2457T hypothetical protein NP_839322.1 4066194 D 198215 CDS NP_839323.1 30065152 1080369 complement(4066673..4067668) 1 NC_004741.1 residues 1 to 331 of 331 are 92.14 pct identical to residues 1 to 331 of 331 from Escherichia coli K-12 : B3561; hypothetical protein 4067668 yiaH 1080369 yiaH Shigella flexneri 2a str. 2457T hypothetical protein NP_839323.1 4066673 R 198215 CDS NP_839324.1 30065153 1080371 4068237..4069148 1 NC_004741.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 4069148 glyQ 1080371 glyQ Shigella flexneri 2a str. 2457T glycyl-tRNA synthetase subunit alpha NP_839324.1 4068237 D 198215 CDS NP_839325.1 30065154 1080372 4069158..4071227 1 NC_004741.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 4071227 glyS 1080372 glyS Shigella flexneri 2a str. 2457T glycyl-tRNA synthetase subunit beta NP_839325.1 4069158 D 198215 CDS NP_839326.1 30065155 1080373 complement(4071285..4071788) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4071788 1080373 S4167 Shigella flexneri 2a str. 2457T IS1 orfB NP_839326.1 4071285 R 198215 CDS NP_839327.1 30065156 1080374 complement(4071707..4071982) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4071982 1080374 S4168 Shigella flexneri 2a str. 2457T IS1 orfA NP_839327.1 4071707 R 198215 CDS NP_839328.1 30065157 1080375 4072203..4072499 1 NC_004741.1 hypothetical protein 4072499 1080375 S4169 Shigella flexneri 2a str. 2457T hypothetical protein NP_839328.1 4072203 D 198215 CDS NP_839329.1 30065158 1080377 complement(4076000..4076728) 1 NC_004741.1 residues 1 to 242 of 242 are 100.00 pct identical to residues 1 to 242 of 242 from Escherichia coli K-12 : B3515; ARAC-type regulatory protein 4076728 yhiW 1080377 yhiW Shigella flexneri 2a str. 2457T ARAC-type regulatory protein NP_839329.1 4076000 R 198215 CDS NP_839330.1 30065159 1080378 complement(4077096..4077920) 1 NC_004741.1 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 4077920 yhiX 1080378 yhiX Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator GadX NP_839330.1 4077096 R 198215 CDS NP_839331.1 30065160 1080379 complement(4078290..4079690) 1 NC_004741.1 residues 1 to 466 of 466 are 99.78 pct identical to residues 1 to 466 of 466 from Escherichia coli K-12 : B3517; glutamate decarboxylase 4079690 gadA 1080379 gadA Shigella flexneri 2a str. 2457T glutamate decarboxylase NP_839331.1 4078290 R 198215 CDS NP_839332.1 30065161 1080380 complement(4079901..4081298) 1 NC_004741.1 residues 1 to 465 of 465 are 99.56 pct identical to residues 1 to 465 of 465 from Escherichia coli K-12 : B3518; cytochrome C peroxidase 4081298 yhjA 1080380 yhjA Shigella flexneri 2a str. 2457T cytochrome C peroxidase NP_839332.1 4079901 R 198215 CDS NP_839333.1 30065162 1080381 complement(4081357..4081860) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4081860 1080381 S4175 Shigella flexneri 2a str. 2457T IS1 orfB NP_839333.1 4081357 R 198215 CDS NP_839334.1 30065163 1080382 complement(4081779..4082054) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4082054 1080382 S4177 Shigella flexneri 2a str. 2457T IS1 orfA NP_839334.1 4081779 R 198215 CDS NP_839335.1 30065164 1080383 4082600..4083451 1 NC_004741.1 residues 1 to 283 of 283 are 99.64 pct identical to residues 1 to 283 of 283 from Escherichia coli K-12 : B3558; IS150 transposase 4083451 1080383 S4178 Shigella flexneri 2a str. 2457T IS150 transposase NP_839335.1 4082600 D 198215 CDS NP_839336.1 30065165 1080384 complement(4083892..4084104) 1 NC_004741.1 residues 1 to 70 of 70 are 100.00 pct identical to residues 1 to 70 of 70 from Escherichia coli K-12 : B3556; major cold shock protein 4084104 cspA 1080384 cspA Shigella flexneri 2a str. 2457T major cold shock protein NP_839336.1 4083892 R 198215 CDS NP_839337.1 30065166 1080385 complement(4084550..4084675) 1 NC_004741.1 residues 1 to 41 of 41 are 100.00 pct identical to residues 1 to 41 of 96 from Escherichia coli K-12 : B3555; hypothetical protein 4084675 yiaG 1080385 yiaG Shigella flexneri 2a str. 2457T hypothetical protein NP_839337.1 4084550 R 198215 CDS NP_839338.1 30065167 1080386 4084989..4085819 1 NC_004741.1 residues 1 to 276 of 276 are 94.56 pct identical to residues 1 to 276 of 276 from Escherichia coli K-12 : B3554; hypothetical protein 4085819 yiaF 1080386 yiaF Shigella flexneri 2a str. 2457T hypothetical protein NP_839338.1 4084989 D 198215 CDS NP_839339.1 30065168 1080387 complement(4085869..4086843) 1 NC_004741.1 Involved in the metabolism of aromatic amino acids; 2-hydroxyacid dehydrogenase 4086843 yiaE 1080387 yiaE Shigella flexneri 2a str. 2457T 2-hydroxyacid dehydrogenase NP_839339.1 4085869 R 198215 CDS NP_839340.2 229089132 1080388 complement(4086947..4087597) 1 NC_004741.1 residues 1 to 208 of 208 are 88.94 pct identical to residues 12 to 219 of 219 from Escherichia coli K-12 : B3552; outer membrane lipoprotein 4087597 yiaD 1080388 yiaD Shigella flexneri 2a str. 2457T outer membrane lipoprotein NP_839340.2 4086947 R 198215 CDS NP_839341.1 30065170 1080389 4087814..4090093 1 NC_004741.1 residues 21 to 759 of 759 are 98.78 pct identical to residues 1 to 739 of 739 from Escherichia coli K-12 : B3551; biotin sulfoxide reductase 4090093 bisC 1080389 bisC Shigella flexneri 2a str. 2457T biotin sulfoxide reductase NP_839341.1 4087814 D 198215 CDS NP_839342.1 30065171 1080390 complement(4090062..4090502) 1 NC_004741.1 residues 1 to 146 of 146 are 97.94 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 : B3550; hypothetical protein 4090502 yiaC 1080390 yiaC Shigella flexneri 2a str. 2457T hypothetical protein NP_839342.1 4090062 R 198215 CDS NP_839343.1 30065172 1080392 complement(4090499..4091062) 1 NC_004741.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyladenine DNA glycosylase 4091062 tag 1080392 tag Shigella flexneri 2a str. 2457T 3-methyladenine DNA glycosylase NP_839343.1 4090499 R 198215 CDS NP_839344.1 30065173 1080393 4091220..4091918 1 NC_004741.1 residues 1 to 232 of 232 are 99.13 pct identical to residues 3 to 234 of 234 from Escherichia coli K-12 : B3548; lipase 4091918 yhjY 1080393 yhjY Shigella flexneri 2a str. 2457T lipase NP_839344.1 4091220 D 198215 CDS NP_839345.1 30065174 1080394 4092147..4093355 1 NC_004741.1 residues 1 to 402 of 402 are 82.08 pct identical to residues 1 to 402 of 402 from Escherichia coli K-12 : B3547; resistance protein 4093355 yhjX 1080394 yhjX Shigella flexneri 2a str. 2457T resistance protein NP_839345.1 4092147 D 198215 CDS NP_839346.2 161486388 1080395 4093679..4095370 1 NC_004741.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 4095370 yhjW 1080395 yhjW Shigella flexneri 2a str. 2457T phosphoethanolamine transferase NP_839346.2 4093679 D 198215 CDS NP_839347.1 30065176 1080397 4096282..4097889 1 NC_004741.1 residues 1 to 535 of 535 are 97.19 pct identical to residues 1 to 535 of 535 from Escherichia coli K-12 : B3544; dipeptide transport protein 4097889 dppA 1080397 dppA Shigella flexneri 2a str. 2457T dipeptide transport protein NP_839347.1 4096282 D 198215 CDS NP_839348.1 30065177 1080398 4098197..4099216 1 NC_004741.1 transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 4099216 dppB 1080398 dppB Shigella flexneri 2a str. 2457T dipeptide transporter permease DppB NP_839348.1 4098197 D 198215 CDS NP_839349.1 30065178 1080399 4099226..4100128 1 NC_004741.1 residues 1 to 300 of 300 are 89.99 pct identical to residues 1 to 300 of 300 from Escherichia coli K-12 : B3542; dipeptide transporter 4100128 dppC 1080399 dppC Shigella flexneri 2a str. 2457T dipeptide transporter NP_839349.1 4099226 D 198215 CDS NP_839350.1 30065179 1080400 4100139..4101122 1 NC_004741.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 4101122 dppD 1080400 dppD Shigella flexneri 2a str. 2457T dipeptide transporter ATP-binding subunit NP_839350.1 4100139 D 198215 CDS NP_839351.1 30065180 1080401 4101119..4102123 1 NC_004741.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 4102123 dppF 1080401 dppF Shigella flexneri 2a str. 2457T dipeptide transporter ATP-binding subunit NP_839351.1 4101119 D 198215 CDS NP_839352.1 30065181 1080402 complement(4102153..4103424) 1 NC_004741.1 residues 1 to 404 of 423 are 96.03 pct identical to residues 1 to 404 of 423 from Escherichia coli K-12 : B3539; transporter protein 4103424 yhjV 1080402 yhjV Shigella flexneri 2a str. 2457T transporter protein NP_839352.1 4102153 R 198215 CDS NP_839353.1 30065182 1080403 complement(4104577..4106256) 1 NC_004741.1 residues 1 to 559 of 559 are 93.73 pct identical to residues 1 to 559 of 559 from Escherichia coli K-12 : B3538; hypothetical protein 4106256 yhjU 1080403 yhjU Shigella flexneri 2a str. 2457T hypothetical protein NP_839353.1 4104577 R 198215 CDS NP_839354.1 30065183 1080404 complement(4106253..4106444) 1 NC_004741.1 residues 2 to 63 of 63 are 85.48 pct identical to residues 1 to 62 of 62 from Escherichia coli K-12 : B3537; hypothetical protein 4106444 yhjT 1080404 yhjT Shigella flexneri 2a str. 2457T hypothetical protein NP_839354.1 4106253 R 198215 CDS NP_839355.1 30065184 1080405 complement(4106441..4108012) 1 NC_004741.1 residues 1 to 523 of 523 are 99.80 pct identical to residues 1 to 523 of 523 from Escherichia coli K-12 : B3536; protease 4108012 yhjS 1080405 yhjS Shigella flexneri 2a str. 2457T protease NP_839355.1 4106441 R 198215 CDS NP_839356.1 30065185 1080406 4108285..4108473 1 NC_004741.1 residues 1 to 62 of 62 are 100.00 pct identical to residues 1 to 62 of 62 from Escherichia coli K-12 : B3535; hypothetical protein 4108473 yhjR 1080406 yhjR Shigella flexneri 2a str. 2457T hypothetical protein NP_839356.1 4108285 D 198215 CDS NP_839357.1 30065186 1080407 4108485..4109237 1 NC_004741.1 residues 24 to 250 of 250 are 99.55 pct identical to residues 16 to 242 of 242 from Escherichia coli K-12 : B3534; cell division protein 4109237 yhjQ 1080407 yhjQ Shigella flexneri 2a str. 2457T cell division protein NP_839357.1 4108485 D 198215 CDS NP_839358.1 30065187 1080409 4111892..4114201 1 NC_004741.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 4114201 yhjN 1080409 yhjN Shigella flexneri 2a str. 2457T cellulose synthase regulator protein NP_839358.1 4111892 D 198215 CDS NP_839359.1 30065188 1080412 4114208..4115314 1 NC_004741.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 4115314 yhjM 1080412 yhjM Shigella flexneri 2a str. 2457T endo-1,4-D-glucanase NP_839359.1 4114208 D 198215 CDS NP_839360.2 229089131 1080416 4117740..4119695 1 NC_004741.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli; phosphodiesterase 4119695 yhjK 1080416 yhjK Shigella flexneri 2a str. 2457T phosphodiesterase NP_839360.2 4117740 D 198215 CDS NP_839361.1 30065190 1080417 4119885..4121171 1 NC_004741.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 4121171 dctA 1080417 dctA Shigella flexneri 2a str. 2457T C4-dicarboxylate transporter DctA NP_839361.1 4119885 D 198215 CDS NP_839362.1 30065191 1080418 4121392..4122888 1 NC_004741.1 residues 1 to 498 of 498 are 94.57 pct identical to residues 1 to 498 of 498 from Escherichia coli K-12 : B3527; hypothetical protein 4122888 yhjJ 1080418 yhjJ Shigella flexneri 2a str. 2457T hypothetical protein NP_839362.1 4121392 D 198215 CDS NP_839363.1 30065192 1080419 complement(4122984..4124132) 1 NC_004741.1 residues 1 to 382 of 382 are 96.07 pct identical to residues 1 to 382 of 382 from Escherichia coli K-12 : B3526; ketodeoxygluconokinase 4124132 kdgK 1080419 kdgK Shigella flexneri 2a str. 2457T ketodeoxygluconokinase NP_839363.1 4122984 R 198215 CDS NP_839364.1 30065193 1080420 4124145..4124912 1 NC_004741.1 in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein 4124912 yhjH 1080420 yhjH Shigella flexneri 2a str. 2457T EAL domain-containing protein NP_839364.1 4124145 D 198215 CDS NP_839365.1 30065194 1080421 4124982..4127042 1 NC_004741.1 residues 1 to 686 of 686 are 88.48 pct identical to residues 6 to 691 of 691 from Escherichia coli K-12 : B3524; hypothetical protein 4127042 yhjG 1080421 yhjG Shigella flexneri 2a str. 2457T hypothetical protein NP_839365.1 4124982 D 198215 CDS NP_839366.1 30065195 1080422 complement(4127224..4128546) 1 NC_004741.1 residues 1 to 440 of 440 are 86.59 pct identical to residues 1 to 440 of 440 from Escherichia coli K-12 : B3523; transporter 4128546 yhjE 1080422 yhjE Shigella flexneri 2a str. 2457T transporter NP_839366.1 4127224 R 198215 CDS NP_839367.1 30065196 1080423 complement(4128957..4129970) 1 NC_004741.1 residues 1 to 337 of 337 are 99.10 pct identical to residues 1 to 337 of 337 from Escherichia coli K-12 : B3522; hypothetical protein 4129970 yhjD 1080423 yhjD Shigella flexneri 2a str. 2457T hypothetical protein NP_839367.1 4128957 R 198215 CDS NP_839368.1 30065197 1080424 complement(4130019..4130990) 1 NC_004741.1 residues 1 to 323 of 323 are 98.14 pct identical to residues 1 to 323 of 323 from Escherichia coli K-12 : B3521; transcriptional regulator LYSR-type 4130990 yhjC 1080424 yhjC Shigella flexneri 2a str. 2457T transcriptional regulator LYSR-type NP_839368.1 4130019 R 198215 CDS NP_839369.1 30065198 1080425 4131438..4132040 1 NC_004741.1 residues 1 to 200 of 200 are 99.00 pct identical to residues 1 to 200 of 200 from Escherichia coli K-12 : B3520; regulator 4132040 yhjB 1080425 yhjB Shigella flexneri 2a str. 2457T regulator NP_839369.1 4131438 D 198215 CDS NP_839370.1 30065199 1080426 complement(4132056..4133384) 1 NC_004741.1 residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 4133384 1080426 S4216 Shigella flexneri 2a str. 2457T IS4 orf NP_839370.1 4132056 R 198215 CDS NP_839371.1 30065200 1080413 complement(4133529..4135178) 1 NC_004741.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 4135178 treF 1080413 treF Shigella flexneri 2a str. 2457T trehalase NP_839371.1 4133529 R 198215 CDS NP_839372.1 30065201 1080427 4135449..4135724 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4135724 1080427 S4218 Shigella flexneri 2a str. 2457T IS1 orfA NP_839372.1 4135449 D 198215 CDS NP_839373.1 30065202 1080428 4135643..4136146 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4136146 1080428 S4219 Shigella flexneri 2a str. 2457T IS1 orfB NP_839373.1 4135643 D 198215 CDS NP_839374.1 30065203 1077417 complement(4137898..4138425) 1 NC_004741.1 residues 1 to 175 of 175 are 100.00 pct identical to residues 1 to 175 of 175 from Escherichia coli K-12 : B3512; hypothetical protein 4138425 yhiE 1077417 yhiE Shigella flexneri 2a str. 2457T hypothetical protein NP_839374.1 4137898 R 198215 CDS NP_839375.1 30065204 1080430 complement(4139224..4139796) 1 NC_004741.1 residues 1 to 190 of 190 are 85.78 pct identical to residues 1 to 190 of 190 from Escherichia coli K-12 : B3511; acid-resistance membrane protein 4139796 hdeD 1080430 hdeD Shigella flexneri 2a str. 2457T acid-resistance membrane protein NP_839375.1 4139224 R 198215 CDS NP_839376.1 30065205 1080431 4140051..4140383 1 NC_004741.1 inactive form; acid-resistance protein 4140383 hdeA 1080431 hdeA Shigella flexneri 2a str. 2457T acid-resistance protein NP_839376.1 4140051 D 198215 CDS NP_839377.1 30065206 1080432 4140487..4140825 1 NC_004741.1 residues 1 to 112 of 112 are 100.00 pct identical to residues 1 to 112 of 112 from Escherichia coli K-12 : B3509; acid-resistance protein 4140825 hdeB 1080432 hdeB Shigella flexneri 2a str. 2457T acid-resistance protein NP_839377.1 4140487 D 198215 CDS NP_839378.1 30065207 1080433 complement(4141577..4142107) 1 NC_004741.1 residues 1 to 176 of 176 are 98.86 pct identical to residues 1 to 176 of 176 from Escherichia coli K-12 : B3507; hypothetical protein 4142107 yhiF 1080433 yhiF Shigella flexneri 2a str. 2457T hypothetical protein NP_839378.1 4141577 R 198215 CDS NP_839379.1 30065208 1080434 complement(4142263..4142862) 1 NC_004741.1 residues 1 to 199 of 199 are 91.95 pct identical to residues 1 to 199 of 199 from Escherichia coli K-12 : B3506; outer membrane protein induced after carbon starvation 4142862 slp 1080434 slp Shigella flexneri 2a str. 2457T outer membrane protein induced after carbon starvation NP_839379.1 4142263 R 198215 CDS NP_839380.1 30065209 1080436 complement(4144880..4145836) 1 NC_004741.1 residues 51 to 317 of 318 are 35.18 pct identical to residues 20 to 274 of 274 from GenPept : >emb|CAB73548.1| (AL139079) membrane protein [Campylobacter jejuni]; hypothetical protein 4145836 1080436 S4229 Shigella flexneri 2a str. 2457T hypothetical protein NP_839380.1 4144880 R 198215 CDS NP_839381.1 30065210 1080437 complement(4145867..4146370) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4146370 1080437 S4230 Shigella flexneri 2a str. 2457T IS1 orfB NP_839381.1 4145867 R 198215 CDS NP_839382.1 30065211 1080438 complement(4146289..4146564) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4146564 1080438 S4231 Shigella flexneri 2a str. 2457T IS1 orfA NP_839382.1 4146289 R 198215 CDS NP_839383.1 30065212 1080440 4146620..4146964 1 NC_004741.1 regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 4146964 arsR 1080440 arsR Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor ArsR NP_839383.1 4146620 D 198215 CDS NP_839384.1 30065213 1080441 4147018..4148307 1 NC_004741.1 residues 1 to 429 of 429 are 89.51 pct identical to residues 8 to 436 of 436 from Escherichia coli K-12 : B3502; arsenical pump membrane protein 4148307 arsB 1080441 arsB Shigella flexneri 2a str. 2457T arsenical pump membrane protein NP_839384.1 4147018 D 198215 CDS NP_839385.1 30065214 1080442 4148320..4148745 1 NC_004741.1 residues 1 to 141 of 141 are 100.00 pct identical to residues 1 to 141 of 141 from Escherichia coli K-12 : B3503; arsenate reductase 4148745 arsC 1080442 arsC Shigella flexneri 2a str. 2457T arsenate reductase NP_839385.1 4148320 D 198215 CDS NP_839386.1 30065215 1080443 4148901..4149176 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfB 4149176 1080443 S4235 Shigella flexneri 2a str. 2457T IS1 orfB NP_839386.1 4148901 D 198215 CDS NP_839387.1 30065216 1080444 4149095..4149598 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 4149598 1080444 S4236 Shigella flexneri 2a str. 2457T IS1 orfB NP_839387.1 4149095 D 198215 CDS NP_839388.1 30065217 1080445 complement(4150511..4151863) 1 NC_004741.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 4151863 gor 1080445 gor Shigella flexneri 2a str. 2457T glutathione reductase NP_839388.1 4150511 R 198215 CDS NP_839389.1 30065218 1080447 complement(4151935..4152777) 1 NC_004741.1 residues 1 to 280 of 280 are 98.57 pct identical to residues 1 to 280 of 280 from Escherichia coli K-12 : B3499; hypothetical protein 4152777 yhiR 1080447 yhiR Shigella flexneri 2a str. 2457T hypothetical protein NP_839389.1 4151935 R 198215 CDS NP_839390.1 30065219 1080414 4152980..4155022 1 NC_004741.1 residues 1 to 680 of 680 are 96.02 pct identical to residues 1 to 680 of 680 from Escherichia coli K-12 : B3498; oligopeptidase A 4155022 prlC 1080414 prlC Shigella flexneri 2a str. 2457T oligopeptidase A NP_839390.1 4152980 D 198215 CDS NP_839391.1 30065220 1080448 4155030..4155782 1 NC_004741.1 predicted SAM-dependent methyltransferase; methyltransferase 4155782 yhiQ 1080448 yhiQ Shigella flexneri 2a str. 2457T methyltransferase NP_839391.1 4155030 D 198215 CDS NP_839392.1 30065221 1080451 complement(4157618..4158052) 1 NC_004741.1 residues 1 to 144 of 144 are 100.00 pct identical to residues 1 to 144 of 144 from Escherichia coli K-12 : B3495; broad regulatory function; universal stress protein 4158052 uspA 1080451 uspA Shigella flexneri 2a str. 2457T universal stress protein NP_839392.1 4157618 R 198215 CDS NP_839393.1 30065222 1080452 4158446..4158781 1 NC_004741.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 4158781 yhiO 1080452 yhiO Shigella flexneri 2a str. 2457T universal stress protein UspB NP_839393.1 4158446 D 198215 CDS NP_839394.1 30065223 1080453 complement(4158852..4160351) 1 NC_004741.1 residues 26 to 499 of 499 are 96.41 pct identical to residues 26 to 499 of 499 from Escherichia coli K-12 : B3493; low-affinity phosphate transport protein 4160351 pitA 1080453 pitA Shigella flexneri 2a str. 2457T low-affinity phosphate transport protein NP_839394.1 4158852 R 198215 CDS NP_839395.1 30065224 1078409 4160583..4161782 1 NC_004741.1 residues 1 to 394 of 399 are 94.41 pct identical to residues 1 to 394 of 400 from Escherichia coli K-12 : B3492; hypothetical protein 4161782 yhiN 1078409 yhiN Shigella flexneri 2a str. 2457T hypothetical protein NP_839395.1 4160583 D 198215 CDS NP_839396.1 30065225 1080454 4162311..4162586 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4162586 1080454 S4246 Shigella flexneri 2a str. 2457T IS1 orfA NP_839396.1 4162311 D 198215 CDS NP_839397.1 30065226 1080457 4162505..4163008 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 4163008 1080457 S4247 Shigella flexneri 2a str. 2457T IS1 orfB NP_839397.1 4162505 D 198215 CDS NP_839398.1 30065227 1080458 complement(4163019..4163318) 1 NC_004741.1 residues 1 to 98 of 99 are 100.00 pct identical to residues 1 to 98 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 4163318 1080458 S4248 Shigella flexneri 2a str. 2457T IS600 orfA NP_839398.1 4163019 R 198215 CDS NP_839399.1 30065228 1080459 4163583..4164608 1 NC_004741.1 residues 1 to 334 of 341 are 22.65 pct identical to residues 229 to 570 of 597 from GenPept : >gb|AAF93566.1| (AE004127) hypothetical protein [Vibrio cholerae]; hypothetical protein 4164608 1080459 S4249 Shigella flexneri 2a str. 2457T hypothetical protein NP_839399.1 4163583 D 198215 CDS NP_839400.1 30065229 1080461 4166011..4166571 1 NC_004741.1 residues 1 to 177 of 186 are 47.54 pct identical to residues 59 to 239 of 241 from GenPept : >gb|AAD26595.1| (AF012835) chaperone protein AafD [Escherichia coli]; chaperone 4166571 1080461 S4250 Shigella flexneri 2a str. 2457T chaperone NP_839400.1 4166011 D 198215 CDS NP_839401.1 30065230 1078396 4166615..4167694 1 NC_004741.1 residues 20 to 356 of 359 are 41.78 pct identical to residues 29 to 375 of 856 from NRprotein_Feb2003 : >gb|AAD27810.1|AF114828_2 aggregative adherence fimbria II usher protein AafC [Escherichia coli]; similar to several fimbrial proteins; fimbrial protein remnant 4167694 1078396 S4254 Shigella flexneri 2a str. 2457T fimbrial protein remnant NP_839401.1 4166615 D 198215 CDS NP_839402.2 161486387 1080462 complement(4167949..4168854) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4168854 1080462 S4252 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_839402.2 4167949 R 198215 CDS NP_839403.2 161486386 1076438 complement(4168812..4169177) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 4169177 1076438 S4253 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_839403.2 4168812 R 198215 CDS NP_839404.1 30065233 1080463 4170556..4171068 1 NC_004741.1 no significant similarities; hypothetical protein 4171068 1080463 S4255 Shigella flexneri 2a str. 2457T hypothetical protein NP_839404.1 4170556 D 198215 CDS NP_839405.1 30065234 1080464 complement(4171175..4171936) 1 NC_004741.1 residues 1 to 253 of 253 are 100.00 pct identical to residues 1 to 253 of 253 from NRprotein_Feb03 : >ref|NP_709260.1| orf, hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN44967.1|AE015359_3 orf, hypothetical protein [Shigella flexneri 2a str. 301]; similar to response regulators; hypothetical protein 4171936 1080464 S4836 Shigella flexneri 2a str. 2457T hypothetical protein NP_839405.1 4171175 R 198215 CDS NP_839406.1 30065235 1080465 4172182..4172946 1 NC_004741.1 residues 1 to 254 of 254 are 100.00 pct identical to residues 1 to 254 of 254 from NRprotein_Feb03 : >ref|NP_709259.1| orf, partial conserved hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN44966.1|AE015359_2 orf, partial conserved hypothetical protein [Shigella flexneri 2a str. 301]; hypothetical protein 4172946 1080465 S4837 Shigella flexneri 2a str. 2457T hypothetical protein NP_839406.1 4172182 D 198215 CDS NP_839407.1 30065236 1080466 4172900..4173415 1 NC_004741.1 residues 1 to 171 of 171 are 100.00 pct identical to residues 1 to 171 of 171 from NRprotein_Feb03 : >ref|NP_709258.1| orf, hypothetical protein [Shigella flexneri 2a str. 301] gb|AAN44965.1|AE015359_1 orf, hypothetical protein [Shigella flexneri 2a str. 301]; hypothetical protein 4173415 1080466 S4838 Shigella flexneri 2a str. 2457T hypothetical protein NP_839407.1 4172900 D 198215 CDS NP_839408.1 30065237 1080470 4176769..4178391 1 NC_004741.1 residues 1 to 540 of 540 are 97.22 pct identical to residues 1 to 540 of 540 from Escherichia coli K-12 : B3488; hypothetical protein 4178391 yhiJ 1080470 yhiJ Shigella flexneri 2a str. 2457T hypothetical protein NP_839408.1 4176769 D 198215 CDS NP_839409.1 30065238 1080471 4178757..4179824 1 NC_004741.1 residues 1 to 355 of 355 are 80.00 pct identical to residues 1 to 355 of 355 from Escherichia coli K-12 : B3487; hypothetical protein 4179824 yhiI 1080471 yhiI Shigella flexneri 2a str. 2457T hypothetical protein NP_839409.1 4178757 D 198215 CDS NP_839410.1 30065239 1080472 4179821..4182556 1 NC_004741.1 residues 18 to 911 of 911 are 94.63 pct identical to residues 1 to 894 of 894 from Escherichia coli K-12 : B3486; ATP-binding component of a transport system 4182556 yhiH 1080472 yhiH Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_839410.1 4179821 D 198215 CDS NP_839411.1 30065240 1080473 4182556..4183680 1 NC_004741.1 residues 1 to 374 of 374 are 88.77 pct identical to residues 2 to 375 of 375 from Escherichia coli K-12 : B3485; transporter 4183680 yhhJ 1080473 yhhJ Shigella flexneri 2a str. 2457T transporter NP_839411.1 4182556 D 198215 CDS NP_839412.1 30065241 1080474 4184011..4184370 1 NC_004741.1 residues 1 to 119 of 119 are 99.15 pct identical to residues 1 to 119 of 119 from GenPept : >gb|AAG58616.1|AE005572_14 (AE005572) Z4882 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 4184370 1080474 S4263 Shigella flexneri 2a str. 2457T hypothetical protein NP_839412.1 4184011 D 198215 CDS NP_839413.1 30065242 1080475 complement(4184490..4184891) 1 NC_004741.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 4184891 yhhG 1080475 yhhG Shigella flexneri 2a str. 2457T nickel responsive regulator NP_839413.1 4184490 R 198215 CDS NP_839414.1 30065243 1080476 complement(4184897..4185703) 1 NC_004741.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 4185703 nikE 1080476 nikE Shigella flexneri 2a str. 2457T nickel transporter ATP-binding protein NikE NP_839414.1 4184897 R 198215 CDS NP_839415.1 30065244 1080477 complement(4185700..4186464) 1 NC_004741.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 4186464 nikD 1080477 nikD Shigella flexneri 2a str. 2457T nickel transporter ATP-binding protein NikD NP_839415.1 4185700 R 198215 CDS NP_839416.1 30065245 1080478 complement(4186464..4187297) 1 NC_004741.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 4187297 nikC 1080478 nikC Shigella flexneri 2a str. 2457T nickel transporter permease NikC NP_839416.1 4186464 R 198215 CDS NP_839417.1 30065246 1079684 complement(4187294..4188238) 1 NC_004741.1 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 4188238 nikB 1079684 nikB Shigella flexneri 2a str. 2457T nickel transporter permease NikB NP_839417.1 4187294 R 198215 CDS NP_839418.1 30065247 1080480 complement(4188238..4189812) 1 NC_004741.1 residues 1 to 524 of 524 are 99.42 pct identical to residues 1 to 524 of 524 from Escherichia coli K-12 : B3476; periplasmic binding protein for nickel 4189812 nikA 1080480 nikA Shigella flexneri 2a str. 2457T periplasmic binding protein for nickel NP_839418.1 4188238 R 198215 CDS NP_839419.1 30065248 1080481 complement(4189923..4190510) 1 NC_004741.1 residues 1 to 195 of 195 are 98.46 pct identical to residues 1 to 195 of 195 from Escherichia coli K-12 : B3475; holo-(acyl carrier protein) synthase 2 4190510 yhhU 1080481 yhhU Shigella flexneri 2a str. 2457T holo-(acyl carrier protein) synthase 2 NP_839419.1 4189923 R 198215 CDS NP_839420.1 30065249 1077976 complement(4190565..4191614) 1 NC_004741.1 residues 1 to 349 of 349 are 95.98 pct identical to residues 28 to 376 of 376 from Escherichia coli K-12 : B3474; hypothetical protein 4191614 yhhT 1077976 yhhT Shigella flexneri 2a str. 2457T hypothetical protein NP_839420.1 4190565 R 198215 CDS NP_839421.2 161486385 1080482 4191748..4192965 1 NC_004741.1 residues 30 to 387 of 419 are 37.70 pct identical to residues 14 to 371 of 392 from Escherichia coli K-12 : B2322; major facilitator superfamily transporter 4192965 yhhS 1080482 yhhS Shigella flexneri 2a str. 2457T major facilitator superfamily transporter NP_839421.2 4191748 D 198215 CDS NP_839422.2 161486384 1080483 complement(4192969..4193526) 1 NC_004741.1 residues 1 to 203 of 203 are 100.00 pct identical to residues 1 to 203 of 203 from Escherichia coli K-12 : B3472; hypothetical protein 4193526 1080483 S4273 Shigella flexneri 2a str. 2457T hypothetical protein NP_839422.2 4192969 R 198215 CDS NP_839423.1 30065252 1080484 complement(4193599..4194264) 1 NC_004741.1 residues 1 to 221 of 221 are 99.54 pct identical to residues 1 to 221 of 221 from Escherichia coli K-12 : B3471; hypothetical protein 4194264 yhhQ 1080484 yhhQ Shigella flexneri 2a str. 2457T hypothetical protein NP_839423.1 4193599 R 198215 CDS NP_839424.1 30065253 1078182 4194485..4194730 1 NC_004741.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 4194730 yhhP 1078182 yhhP Shigella flexneri 2a str. 2457T sulfur transfer protein SirA NP_839424.1 4194485 D 198215 CDS NP_839425.1 30065254 1080485 complement(4194832..4197030) 1 NC_004741.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 4197030 zntA 1080485 zntA Shigella flexneri 2a str. 2457T zinc/cadmium/mercury/lead-transporting ATPase NP_839425.1 4194832 R 198215 CDS NP_839426.1 30065255 1080486 complement(4197104..4197730) 1 NC_004741.1 residues 1 to 208 of 208 are 88.46 pct identical to residues 1 to 208 of 208 from Escherichia coli K-12 : B3468; enzyme 4197730 yhhN 1080486 yhhN Shigella flexneri 2a str. 2457T enzyme NP_839426.1 4197104 R 198215 CDS NP_839427.1 30065256 1080487 4197871..4198230 1 NC_004741.1 residues 1 to 119 of 119 are 89.07 pct identical to residues 1 to 119 of 119 from Escherichia coli K-12 : B3467; receptor 4198230 yhhM 1080487 yhhM Shigella flexneri 2a str. 2457T receptor NP_839427.1 4197871 D 198215 CDS NP_839428.1 30065257 1080488 complement(4198233..4198502) 1 NC_004741.1 residues 1 to 89 of 89 are 98.87 pct identical to residues 1 to 89 of 89 from Escherichia coli K-12 : B3466; hypothetical protein 4198502 yhhL 1080488 yhhL Shigella flexneri 2a str. 2457T hypothetical protein NP_839428.1 4198233 R 198215 CDS NP_839429.1 30065258 1077575 complement(4198492..4199088) 1 NC_004741.1 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 4199088 rsmD 1077575 rsmD Shigella flexneri 2a str. 2457T 16S rRNA m(2)G966-methyltransferase NP_839429.1 4198492 R 198215 CDS NP_839430.1 30065259 1080489 4199238..4200734 1 NC_004741.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 4200734 ftsY 1080489 ftsY Shigella flexneri 2a str. 2457T cell division protein FtsY NP_839430.1 4199238 D 198215 CDS NP_839431.1 30065260 1080490 4200737..4201405 1 NC_004741.1 ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 4201405 ftsE 1080490 ftsE Shigella flexneri 2a str. 2457T cell division protein FtsE NP_839431.1 4200737 D 198215 CDS NP_839432.1 30065261 1080491 4201398..4202456 1 NC_004741.1 ABC transporter membrane protein; cell division protein FtsX 4202456 ftsX 1080491 ftsX Shigella flexneri 2a str. 2457T cell division protein FtsX NP_839432.1 4201398 D 198215 CDS NP_839433.1 30065262 1080492 4202701..4203555 1 NC_004741.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 4203555 rpoH 1080492 rpoH Shigella flexneri 2a str. 2457T RNA polymerase factor sigma-32 NP_839433.1 4202701 D 198215 CDS NP_839434.1 30065263 1080493 4203769..4204929 1 NC_004741.1 residues 1 to 386 of 386 are 97.15 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 : B3460; high-affinity amino acid transport protein, periplasmic binding protein 4204929 livJ 1080493 livJ Shigella flexneri 2a str. 2457T high-affinity amino acid transport protein, periplasmic binding protein NP_839434.1 4203769 D 198215 CDS NP_839435.1 30065264 1078285 complement(4205128..4205511) 1 NC_004741.1 residues 1 to 126 of 127 are 89.68 pct identical to residues 1 to 126 of 127 from Escherichia coli K-12 : B3459; hypothetical protein 4205511 yhhK 1078285 yhhK Shigella flexneri 2a str. 2457T hypothetical protein NP_839435.1 4205128 R 198215 CDS NP_839436.1 30065265 1080494 4205935..4207044 1 NC_004741.1 residues 1 to 369 of 369 are 99.72 pct identical to residues 1 to 369 of 369 from Escherichia coli K-12 : B3458; high-affinity leucine-specific transport protein, periplasmic binding protein 4207044 livK 1080494 livK Shigella flexneri 2a str. 2457T high-affinity leucine-specific transport protein, periplasmic binding protein NP_839436.1 4205935 D 198215 CDS NP_839437.1 30065266 1076553 4207092..4208018 1 NC_004741.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid ABC transporter permease 4208018 livH 1076553 livH Shigella flexneri 2a str. 2457T branched-chain amino acid ABC transporter permease NP_839437.1 4207092 D 198215 CDS NP_839438.1 30065267 1080495 4208015..4209292 1 NC_004741.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit 4209292 livM 1080495 livM Shigella flexneri 2a str. 2457T leucine/isoleucine/valine transporter permease subunit NP_839438.1 4208015 D 198215 CDS NP_839439.1 30065268 1080496 4209289..4210056 1 NC_004741.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 4210056 livG 1080496 livG Shigella flexneri 2a str. 2457T leucine/isoleucine/valine transporter ATP-binding subunit NP_839439.1 4209289 D 198215 CDS NP_839440.1 30065269 1080497 4210058..4210771 1 NC_004741.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 4210771 livF 1080497 livF Shigella flexneri 2a str. 2457T leucine/isoleucine/valine transporter ATP-binding subunit NP_839440.1 4210058 D 198215 CDS NP_839441.1 30065270 1080498 4211168..4212484 1 NC_004741.1 with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein 4212484 ugpB 1080498 ugpB Shigella flexneri 2a str. 2457T glycerol-3-phosphate transporter periplasmic binding protein NP_839441.1 4211168 D 198215 CDS NP_839442.1 30065271 1080499 4212582..4213469 1 NC_004741.1 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 4213469 ugpA 1080499 ugpA Shigella flexneri 2a str. 2457T glycerol-3-phosphate transporter permease NP_839442.1 4212582 D 198215 CDS NP_839443.1 30065272 1080500 4213466..4214311 1 NC_004741.1 with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 4214311 ugpE 1080500 ugpE Shigella flexneri 2a str. 2457T glycerol-3-phosphate transporter membrane protein NP_839443.1 4213466 D 198215 CDS NP_839444.1 30065273 1080502 4215300..4216043 1 NC_004741.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; glycerophosphodiester phosphodiesterase 4216043 ugpQ 1080502 ugpQ Shigella flexneri 2a str. 2457T glycerophosphodiester phosphodiesterase NP_839444.1 4215300 D 198215 CDS NP_839445.1 30065274 1080504 complement(4216030..4216470) 1 NC_004741.1 residues 1 to 146 of 146 are 71.23 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 : B3448; hypothetical protein 4216470 yhhA 1080504 yhhA Shigella flexneri 2a str. 2457T hypothetical protein NP_839445.1 4216030 R 198215 CDS NP_839446.1 30065275 1080506 4216590..4218332 1 NC_004741.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 4218332 ggt 1080506 ggt Shigella flexneri 2a str. 2457T gamma-glutamyltranspeptidase NP_839446.1 4216590 D 198215 CDS NP_839447.1 30065276 1080507 complement(4218391..4218879) 1 NC_004741.1 YhhY; regulated by the fur regulator; unknown function; acetyltransferase YhhY 4218879 yhhY 1080507 yhhY Shigella flexneri 2a str. 2457T acetyltransferase YhhY NP_839447.1 4218391 R 198215 CDS NP_839448.1 30065277 1080508 4219212..4220249 1 NC_004741.1 residues 1 to 344 of 345 are 99.70 pct identical to residues 1 to 344 of 345 from Escherichia coli K-12 : B3440; dehydrogenase 4220249 yhhX 1080508 yhhX Shigella flexneri 2a str. 2457T dehydrogenase NP_839448.1 4219212 D 198215 CDS NP_839449.1 30065278 1080509 4220372..4221067 1 NC_004741.1 residues 1 to 231 of 231 are 99.56 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 : B3439; hypothetical protein 4221067 yhhW 1080509 yhhW Shigella flexneri 2a str. 2457T hypothetical protein NP_839449.1 4220372 D 198215 CDS NP_839450.1 30065279 1080510 4221348..4222286 1 NC_004741.1 residues 1 to 285 of 312 are 97.54 pct identical to residues 20 to 304 of 313 from Escherichia coli K-12 : B3438; regulator of gluconate (gnt) operon 4222286 gntR 1080510 gntR Shigella flexneri 2a str. 2457T regulator of gluconate (gnt) operon NP_839450.1 4221348 D 198215 CDS NP_839451.2 161486383 1078250 4222425..4222952 1 NC_004741.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 4222952 gntK 1078250 gntK Shigella flexneri 2a str. 2457T gluconate kinase NP_839451.2 4222425 D 198215 CDS NP_839452.1 30065281 1080511 4223019..4224296 1 NC_004741.1 residues 1 to 425 of 425 are 99.52 pct identical to residues 22 to 446 of 446 from NRprotein_Feb2003 : >ref|NP_289984.1| low-affinity gluconate permease [Escherichia coli O157:H7 EDL933] ref|NP_417893.1| H+/gluconate symporter [Escherichia coli K12] sp|P46858|GNTU_ECOLI Low-affinity gluconate transporter (Gluconate permease)[Escherichia coli]; low affinity gluconate transporter 4224296 gntU 1080511 gntU Shigella flexneri 2a str. 2457T low affinity gluconate transporter NP_839452.1 4223019 D 198215 CDS NP_839453.1 30065282 1080512 complement(4224353..4224946) 1 NC_004741.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase 4224946 yhgN 1080512 yhgN Shigella flexneri 2a str. 2457T dITP- and XTP- hydrolase NP_839453.1 4224353 R 198215 CDS NP_839454.1 30065283 1080513 4225138..4226241 1 NC_004741.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 4226241 asd 1080513 asd Shigella flexneri 2a str. 2457T aspartate-semialdehyde dehydrogenase NP_839454.1 4225138 D 198215 CDS NP_839455.1 30065284 1080514 4226514..4228700 1 NC_004741.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 4228700 glgB 1080514 glgB Shigella flexneri 2a str. 2457T glycogen branching enzyme NP_839455.1 4226514 D 198215 CDS NP_839456.1 30065285 1080515 4228697..4230670 1 NC_004741.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme 4230670 glgX 1080515 glgX Shigella flexneri 2a str. 2457T glycogen debranching enzyme NP_839456.1 4228697 D 198215 CDS NP_839457.1 30065286 1080516 4230688..4231983 1 NC_004741.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 4231983 glgC 1080516 glgC Shigella flexneri 2a str. 2457T glucose-1-phosphate adenylyltransferase NP_839457.1 4230688 D 198215 CDS NP_839458.1 30065287 1080517 4231983..4233416 1 NC_004741.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 4233416 glgA 1080517 glgA Shigella flexneri 2a str. 2457T glycogen synthase NP_839458.1 4231983 D 198215 CDS NP_839459.1 30065288 1080518 4233435..4235882 1 NC_004741.1 residues 1 to 815 of 815 are 97.30 pct identical to residues 1 to 815 of 815 from Escherichia coli K-12 : B3428; glycogen phosphorylase 4235882 glgP 1080518 glgP Shigella flexneri 2a str. 2457T glycogen phosphorylase NP_839459.1 4233435 D 198215 CDS NP_839460.1 30065289 1080519 4236000..4236866 1 NC_004741.1 residues 1 to 284 of 288 are 98.94 pct identical to residues 7 to 290 of 439 from GenPept : >gb|AAK18553.1|AF348706_242 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 4236866 1080519 S4313 Shigella flexneri 2a str. 2457T IS4 orf NP_839460.1 4236000 D 198215 CDS NP_839461.1 30065290 1080520 4236872..4237327 1 NC_004741.1 residues 1 to 151 of 151 are 99.33 pct identical to residues 298 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 4237327 1080520 S4314 Shigella flexneri 2a str. 2457T IS4 orf NP_839461.1 4236872 D 198215 CDS NP_839462.1 30065291 1080522 complement(4237934..4239412) 1 NC_004741.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 4239412 glpD 1080522 glpD Shigella flexneri 2a str. 2457T glycerol-3-phosphate dehydrogenase NP_839462.1 4237934 R 198215 CDS NP_839463.1 30065292 1080921 4239630..4239956 1 NC_004741.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 4239956 glpE 1080921 glpE Shigella flexneri 2a str. 2457T thiosulfate sulfurtransferase NP_839463.1 4239630 D 198215 CDS NP_839464.1 30065293 1080967 4240007..4240831 1 NC_004741.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 4240831 glpG 1080967 glpG Shigella flexneri 2a str. 2457T intramembrane serine protease GlpG NP_839464.1 4240007 D 198215 CDS NP_839465.1 30065294 1080523 4240848..4241606 1 NC_004741.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 4241606 glpR 1080523 glpR Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor GlpR NP_839465.1 4240848 D 198215 CDS NP_839466.1 30065295 1080524 complement(4241588..4243186) 1 NC_004741.1 residues 1 to 532 of 532 are 98.68 pct identical to residues 1 to 532 of 532 from Escherichia coli K-12 : B3422; 2-component regulator 4243186 rtcR 1080524 rtcR Shigella flexneri 2a str. 2457T 2-component regulator NP_839466.1 4241588 R 198215 CDS NP_839467.1 30065296 1080525 4243367..4244593 1 NC_004741.1 residues 1 to 408 of 408 are 98.28 pct identical to residues 1 to 408 of 408 from Escherichia coli K-12 : B3421; hypothetical protein 4244593 rtcB 1080525 rtcB Shigella flexneri 2a str. 2457T hypothetical protein NP_839467.1 4243367 D 198215 CDS NP_839468.1 30065297 1080527 4245008..4245613 1 NC_004741.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 4245613 yhgJ 1080527 yhgJ Shigella flexneri 2a str. 2457T RNA 3'-terminal-phosphate cyclase NP_839468.1 4245008 D 198215 CDS NP_839469.1 30065298 1080529 4248973..4251366 1 NC_004741.1 residues 1 to 797 of 797 are 94.47 pct identical to residues 1 to 797 of 797 from Escherichia coli K-12 : B3417; maltodextrin phosphorylase 4251366 malP 1080529 malP Shigella flexneri 2a str. 2457T maltodextrin phosphorylase NP_839469.1 4248973 D 198215 CDS NP_839470.1 30065299 1080530 4251376..4253460 1 NC_004741.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 4253460 malQ 1080530 malQ Shigella flexneri 2a str. 2457T 4-alpha-glucanotransferase NP_839470.1 4251376 D 198215 CDS NP_839471.1 30065300 1080532 complement(4253505..4254821) 1 NC_004741.1 residues 17 to 438 of 438 are 88.38 pct identical to residues 17 to 437 of 437 from Escherichia coli K-12 : B3415; high-affinity transport permease for gluconate 4254821 gntT 1080532 gntT Shigella flexneri 2a str. 2457T high-affinity transport permease for gluconate NP_839471.1 4253505 R 198215 CDS NP_839472.1 30065301 1080533 complement(4255182..4255757) 1 NC_004741.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 4255757 yhgI 1080533 yhgI Shigella flexneri 2a str. 2457T DNA uptake protein NP_839472.1 4255182 R 198215 CDS NP_839473.2 161486382 1080534 complement(4255816..4256499) 1 NC_004741.1 involved in high-affinity gluconate transport; gluconate periplasmic binding protein 4256499 yhgH 1080534 yhgH Shigella flexneri 2a str. 2457T gluconate periplasmic binding protein NP_839473.2 4255816 R 198215 CDS NP_839474.1 30065303 1080535 4256537..4257325 1 NC_004741.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 4257325 bioH 1080535 bioH Shigella flexneri 2a str. 2457T carboxylesterase BioH NP_839474.1 4256537 D 198215 CDS NP_839475.2 161486381 1080536 complement(4258051..4258956) 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4258956 1080536 S4331 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_839475.2 4258051 R 198215 CDS NP_839476.2 161486380 1080537 complement(4258914..4259279) 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 4259279 1080537 S4332 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_839476.2 4258914 R 198215 CDS NP_839477.1 30065306 1080538 complement(4259355..4260242) 1 NC_004741.1 residues 1 to 281 of 295 are 99.28 pct identical to residues 1 to 281 of 292 from Escherichia coli K-12 : B3411; hypothetical protein 4260242 yhgA 1080538 yhgA Shigella flexneri 2a str. 2457T hypothetical protein NP_839477.1 4259355 R 198215 CDS NP_839478.1 30065307 1080539 complement(4260445..4260681) 1 NC_004741.1 residues 1 to 78 of 78 are 98.71 pct identical to residues 1 to 78 of 78 from Escherichia coli K-12 : B3410; hypothetical protein 4260681 yhgG 1080539 yhgG Shigella flexneri 2a str. 2457T hypothetical protein NP_839478.1 4260445 R 198215 CDS NP_839479.1 30065308 1080540 complement(4260681..4263002) 1 NC_004741.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 4263002 feoB 1080540 feoB Shigella flexneri 2a str. 2457T ferrous iron transport protein B NP_839479.1 4260681 R 198215 CDS NP_839480.1 30065309 1080541 complement(4263019..4263246) 1 NC_004741.1 residues 1 to 75 of 75 are 98.66 pct identical to residues 1 to 75 of 75 from Escherichia coli K-12 : B3408; ferrous iron transport protein A 4263246 feoA 1080541 feoA Shigella flexneri 2a str. 2457T ferrous iron transport protein A NP_839480.1 4263019 R 198215 CDS NP_839481.1 30065310 1080542 complement(4263684..4265906) 1 NC_004741.1 residues 1 to 740 of 740 are 97.56 pct identical to residues 1 to 740 of 740 from Escherichia coli K-12 : B3407; hypothetical protein 4265906 yhgF 1080542 yhgF Shigella flexneri 2a str. 2457T hypothetical protein NP_839481.1 4263684 R 198215 CDS NP_839482.2 161486379 1080543 complement(4266102..4266578) 1 NC_004741.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 4266578 greB 1080543 greB Shigella flexneri 2a str. 2457T transcription elongation factor GreB NP_839482.2 4266102 R 198215 CDS NP_839483.1 30065312 1080544 4266806..4267525 1 NC_004741.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 4267525 ompR 1080544 ompR Shigella flexneri 2a str. 2457T osmolarity response regulator NP_839483.1 4266806 D 198215 CDS NP_839484.1 30065313 1080545 4267522..4268874 1 NC_004741.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 4268874 envZ 1080545 envZ Shigella flexneri 2a str. 2457T osmolarity sensor protein NP_839484.1 4267522 D 198215 CDS NP_839485.1 30065314 1080546 complement(4268950..4270572) 1 NC_004741.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 4270572 pckA 1080546 pckA Shigella flexneri 2a str. 2457T phosphoenolpyruvate carboxykinase NP_839485.1 4268950 R 198215 CDS NP_839486.1 30065315 1080547 4270951..4272702 1 NC_004741.1 residues 1 to 583 of 583 are 79.24 pct identical to residues 1 to 574 of 574 from Escherichia coli K-12 : B3402; transporter 4272702 yhgE 1080547 yhgE Shigella flexneri 2a str. 2457T transporter NP_839486.1 4270951 D 198215 CDS NP_839487.1 30065316 1080548 complement(4272846..4273715) 1 NC_004741.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 4273715 hslO 1080548 hslO Shigella flexneri 2a str. 2457T Hsp33-like chaperonin NP_839487.1 4272846 R 198215 CDS NP_839488.1 30065317 1080550 complement(4273740..4274141) 1 NC_004741.1 residues 1 to 133 of 133 are 87.96 pct identical to residues 1 to 133 of 133 from Escherichia coli K-12 : B3400; ribosome-associated heat shock protein Hsp15 4274141 yrfH 1080550 yrfH Shigella flexneri 2a str. 2457T ribosome-associated heat shock protein Hsp15 NP_839488.1 4273740 R 198215 CDS NP_839489.1 30065318 1080551 complement(4274152..4274865) 1 NC_004741.1 residues 1 to 237 of 237 are 100.00 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B3399; phosphatase 4274865 yrfG 1080551 yrfG Shigella flexneri 2a str. 2457T phosphatase NP_839489.1 4274152 R 198215 CDS NP_839490.1 30065319 1080552 complement(4274885..4277020) 1 NC_004741.1 residues 1 to 711 of 711 are 93.81 pct identical to residues 1 to 711 of 711 from Escherichia coli K-12 : B3398; dehydrogenase 4277020 yrfF 1080552 yrfF Shigella flexneri 2a str. 2457T dehydrogenase NP_839490.1 4274885 R 198215 CDS NP_839491.1 30065320 1079335 4277340..4277900 1 NC_004741.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 4277900 nudE 1079335 nudE Shigella flexneri 2a str. 2457T ADP-ribose diphosphatase NudE NP_839491.1 4277340 D 198215 CDS NP_839492.3 229089130 1080554 complement(4278065..4280617) 1 NC_004741.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 4280617 mrcA 1080554 mrcA Shigella flexneri 2a str. 2457T peptidoglycan synthetase NP_839492.3 4278065 R 198215 CDS NP_839493.1 30065322 1080556 4280710..4281516 1 NC_004741.1 residues 1 to 268 of 268 are 93.28 pct identical to residues 1 to 268 of 268 from Escherichia coli K-12 : B3395; hypothetical protein 4281516 yrfD 1080556 yrfD Shigella flexneri 2a str. 2457T hypothetical protein NP_839493.1 4280710 D 198215 CDS NP_839494.1 30065323 1080557 4281516..4282055 1 NC_004741.1 residues 1 to 179 of 179 are 80.44 pct identical to residues 1 to 179 of 179 from Escherichia coli K-12 : B3394; hypothetical protein 4282055 yrfC 1080557 yrfC Shigella flexneri 2a str. 2457T hypothetical protein NP_839494.1 4281516 D 198215 CDS NP_839495.1 30065324 1080559 4282039..4282479 1 NC_004741.1 residues 1 to 146 of 146 are 97.94 pct identical to residues 1 to 146 of 146 from Escherichia coli K-12 : B3393; hypothetical protein 4282479 yrfB 1080559 yrfB Shigella flexneri 2a str. 2457T hypothetical protein NP_839495.1 4282039 D 198215 CDS NP_839496.1 30065325 1080561 4282787..4284025 1 NC_004741.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ 4284025 hofQ 1080561 hofQ Shigella flexneri 2a str. 2457T outer membrane porin HofQ NP_839496.1 4282787 D 198215 CDS NP_839497.2 161486377 1080562 4284426..4284947 1 NC_004741.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 4284947 aroK 1080562 aroK Shigella flexneri 2a str. 2457T shikimate kinase I NP_839497.2 4284426 D 198215 CDS NP_839498.1 30065327 1079948 4285004..4286092 1 NC_004741.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 4286092 aroB 1079948 aroB Shigella flexneri 2a str. 2457T 3-dehydroquinate synthase NP_839498.1 4285004 D 198215 CDS NP_839499.1 30065328 1080563 4286184..4287476 1 NC_004741.1 residues 1 to 430 of 430 are 61.39 pct identical to residues 1 to 428 of 428 from Escherichia coli K-12 : B3388; interferes with cell division; hypothetical protein 4287476 damX 1080563 damX Shigella flexneri 2a str. 2457T hypothetical protein NP_839499.1 4286184 D 198215 CDS NP_839500.1 30065329 1076430 4287583..4288419 1 NC_004741.1 residues 1 to 278 of 278 are 99.64 pct identical to residues 1 to 278 of 278 from Escherichia coli K-12 : B3387; DNA adenine methylase 4288419 dam 1076430 dam Shigella flexneri 2a str. 2457T DNA adenine methylase NP_839500.1 4287583 D 198215 CDS NP_839501.1 30065330 1080564 4288437..4289114 1 NC_004741.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 4289114 rpe 1080564 rpe Shigella flexneri 2a str. 2457T ribulose-phosphate 3-epimerase NP_839501.1 4288437 D 198215 CDS NP_839502.1 30065331 1080565 4289107..4289865 1 NC_004741.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 4289865 gph 1080565 gph Shigella flexneri 2a str. 2457T phosphoglycolate phosphatase NP_839502.1 4289107 D 198215 CDS NP_839503.1 30065332 1080566 4289858..4290862 1 NC_004741.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 4290862 trpS 1080566 trpS Shigella flexneri 2a str. 2457T tryptophanyl-tRNA synthetase NP_839503.1 4289858 D 198215 CDS NP_839504.1 30065333 1080567 4291351..4292037 1 NC_004741.1 residues 1 to 228 of 228 are 96.49 pct identical to residues 1 to 228 of 228 from Escherichia coli K-12 : B3383; hypothetical protein 4292037 yhfZ 1080567 yhfZ Shigella flexneri 2a str. 2457T hypothetical protein NP_839504.1 4291351 D 198215 CDS NP_839505.1 30065334 1080568 4292012..4292416 1 NC_004741.1 residues 1 to 134 of 134 are 96.26 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B3382; hypothetical protein 4292416 yhfY 1080568 yhfY Shigella flexneri 2a str. 2457T hypothetical protein NP_839505.1 4292012 D 198215 CDS NP_839506.1 30065335 1080570 4292500..4293663 1 NC_004741.1 residues 1 to 387 of 387 are 91.47 pct identical to residues 1 to 387 of 387 from Escherichia coli K-12 : B3381; hypothetical protein 4293663 yhfX 1080570 yhfX Shigella flexneri 2a str. 2457T hypothetical protein NP_839506.1 4292500 D 198215 CDS NP_839507.1 30065336 1080571 4293664..4294890 1 NC_004741.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; mutase 4294890 yhfW 1080571 yhfW Shigella flexneri 2a str. 2457T mutase NP_839507.1 4293664 D 198215 CDS NP_839508.1 30065337 1080572 4294887..4295765 1 NC_004741.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); hydrolase 4295765 yhfV 1080572 yhfV Shigella flexneri 2a str. 2457T hydrolase NP_839508.1 4294887 D 198215 CDS NP_839509.1 30065338 1080573 4295737..4296129 1 NC_004741.1 residues 1 to 130 of 130 are 100.00 pct identical to residues 1 to 130 of 130 from Escherichia coli K-12 : B3378; hypothetical protein 4296129 yhfU 1080573 yhfU Shigella flexneri 2a str. 2457T hypothetical protein NP_839509.1 4295737 D 198215 CDS NP_839510.1 30065339 1080574 4296141..4297445 1 NC_004741.1 residues 1 to 434 of 434 are 93.08 pct identical to residues 1 to 434 of 434 from Escherichia coli K-12 : B3377; transport system permease 4297445 yhfT 1080574 yhfT Shigella flexneri 2a str. 2457T transport system permease NP_839510.1 4296141 D 198215 CDS NP_839511.1 30065340 1080575 4297457..4298542 1 NC_004741.1 residues 1 to 361 of 361 are 86.70 pct identical to residues 1 to 361 of 361 from Escherichia coli K-12 : B3376; hypothetical protein 4298542 yhfS 1080575 yhfS Shigella flexneri 2a str. 2457T hypothetical protein NP_839511.1 4297457 D 198215 CDS NP_839512.1 30065341 1080577 complement(4298702..4299499) 1 NC_004741.1 may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 4299499 yhfR 1080577 yhfR Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator FrlR NP_839512.1 4298702 R 198215 CDS NP_839513.1 30065342 1080578 complement(4299533..4300318) 1 NC_004741.1 residues 1 to 261 of 261 are 99.23 pct identical to residues 1 to 261 of 261 from Escherichia coli K-12 : B3374; fructoselysine 6-kinase 4300318 yhfQ 1080578 yhfQ Shigella flexneri 2a str. 2457T fructoselysine 6-kinase NP_839513.1 4299533 R 198215 CDS NP_839514.1 30065343 1080579 complement(4300315..4301145) 1 NC_004741.1 YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase 4301145 yhfP 1080579 yhfP Shigella flexneri 2a str. 2457T fructoselysine 3-epimerase NP_839514.1 4300315 R 198215 CDS NP_839515.2 161486376 1080581 complement(4301195..4302238) 1 NC_004741.1 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 4302238 frlB 1080581 frlB Shigella flexneri 2a str. 2457T fructoselysine-6-P-deglycase NP_839515.2 4301195 R 198215 CDS NP_839516.1 30065345 1080583 complement(4303870..4304037) 1 NC_004741.1 residues 1 to 55 of 55 are 70.90 pct identical to residues 1 to 55 of 55 from Escherichia coli K-12 : B3369; hypothetical protein 4304037 yhfL 1080583 yhfL Shigella flexneri 2a str. 2457T hypothetical protein NP_839516.1 4303870 R 198215 CDS NP_839517.1 30065346 1080584 complement(4304284..4305657) 1 NC_004741.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 4305657 cysG 1080584 cysG Shigella flexneri 2a str. 2457T siroheme synthase NP_839517.1 4304284 R 198215 CDS NP_839518.1 30065347 1080585 complement(4305676..4306230) 1 NC_004741.1 residues 1 to 184 of 184 are 100.00 pct identical to residues 1 to 184 of 184 from Escherichia coli K-12 : B3367; nitrite reductase, NirC protein 4306230 nirC 1080585 nirC Shigella flexneri 2a str. 2457T nitrite reductase, NirC protein NP_839518.1 4305676 R 198215 CDS NP_839519.1 30065348 1080586 complement(4306608..4306934) 1 NC_004741.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 4306934 nirD 1080586 nirD Shigella flexneri 2a str. 2457T nitrite reductase small subunit NP_839519.1 4306608 R 198215 CDS NP_839520.1 30065349 1080587 complement(4306931..4309474) 1 NC_004741.1 residues 1 to 847 of 847 are 97.87 pct identical to residues 1 to 847 of 847 from Escherichia coli K-12 : B3365; nitrite reductase (NAD(P)H) subunit 4309474 nirB 1080587 nirB Shigella flexneri 2a str. 2457T nitrite reductase (NAD(P)H) subunit NP_839520.1 4306931 R 198215 CDS NP_839521.1 30065350 1080588 complement(4309736..4310917) 1 NC_004741.1 residues 1 to 393 of 393 are 98.72 pct identical to residues 1 to 393 of 393 from Escherichia coli K-12 : B3364; hypothetical protein 4310917 yhfC 1080588 yhfC Shigella flexneri 2a str. 2457T hypothetical protein NP_839521.1 4309736 R 198215 CDS NP_839522.1 30065351 1080589 4311188..4311769 1 NC_004741.1 residues 29 to 193 of 193 are 100.00 pct identical to residues 26 to 190 of 190 from Escherichia coli K-12 : B3363; peptidyl-prolyl cis-trans isomerase A (rotamase A) 4311769 ppiA 1080589 ppiA Shigella flexneri 2a str. 2457T peptidyl-prolyl cis-trans isomerase A (rotamase A) NP_839522.1 4311188 D 198215 CDS NP_839523.1 30065352 1080590 4311874..4312041 1 NC_004741.1 residues 1 to 36 of 55 are 100.00 pct identical to residues 1 to 36 of 55 from Escherichia coli K-12 : B3362; hypothetical protein 4312041 yhfG 1080590 yhfG Shigella flexneri 2a str. 2457T hypothetical protein NP_839523.1 4311874 D 198215 CDS NP_839524.1 30065353 1080591 4312031..4312633 1 NC_004741.1 residues 1 to 200 of 200 are 92.50 pct identical to residues 1 to 200 of 200 from Escherichia coli K-12 : B3361; recognized by rpoS, affects cell division; cell filamentation protein Fic 4312633 fic 1080591 fic Shigella flexneri 2a str. 2457T cell filamentation protein Fic NP_839524.1 4312031 D 198215 CDS NP_839525.1 30065354 1080592 4312665..4313228 1 NC_004741.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 4313228 pabA 1080592 pabA Shigella flexneri 2a str. 2457T para-aminobenzoate synthase component II NP_839525.1 4312665 D 198215 CDS NP_839526.1 30065355 1080593 4313314..4314534 1 NC_004741.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein 4314534 argD 1080593 argD Shigella flexneri 2a str. 2457T bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein NP_839526.1 4313314 D 198215 CDS NP_839527.1 30065356 1080594 complement(4314601..4316691) 1 NC_004741.1 residues 1 to 696 of 696 are 94.68 pct identical to residues 1 to 696 of 696 from Escherichia coli K-12 : B3358; hypothetical protein 4316691 yhfK 1080594 yhfK Shigella flexneri 2a str. 2457T hypothetical protein NP_839527.1 4314601 R 198215 CDS NP_839528.1 30065357 1080595 complement(4316742..4317374) 1 NC_004741.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 4317374 crp 1080595 crp Shigella flexneri 2a str. 2457T cAMP-regulatory protein NP_839528.1 4316742 R 198215 CDS NP_839529.1 30065358 1080596 4317676..4318080 1 NC_004741.1 residues 1 to 134 of 134 are 100.00 pct identical to residues 1 to 134 of 134 from Escherichia coli K-12 : B3356; hypothetical protein 4318080 yhfA 1080596 yhfA Shigella flexneri 2a str. 2457T hypothetical protein NP_839529.1 4317676 D 198215 CDS NP_839530.1 30065359 1080597 complement(4318135..4319004) 1 NC_004741.1 residues 1 to 289 of 289 are 95.84 pct identical to residues 1 to 289 of 289 from Escherichia coli K-12 : B3355; phosphoribulokinase 4319004 prkB 1080597 prkB Shigella flexneri 2a str. 2457T phosphoribulokinase NP_839530.1 4318135 R 198215 CDS NP_839531.1 30065360 1080598 complement(4319058..4319276) 1 NC_004741.1 residues 1 to 72 of 72 are 100.00 pct identical to residues 1 to 72 of 72 from Escherichia coli K-12 : B3354; hypothetical protein 4319276 yheU 1080598 yheU Shigella flexneri 2a str. 2457T hypothetical protein NP_839531.1 4319058 R 198215 CDS NP_839532.1 30065361 1080599 complement(4319270..4320292) 1 NC_004741.1 residues 1 to 340 of 340 are 93.23 pct identical to residues 1 to 340 of 340 from Escherichia coli K-12 : B3353; hydrolase 4320292 yheT 1080599 yheT Shigella flexneri 2a str. 2457T hydrolase NP_839532.1 4319270 R 198215 CDS NP_839533.1 30065362 1080600 complement(4320292..4322205) 1 NC_004741.1 residues 1 to 620 of 637 are 99.67 pct identical to residues 1 to 620 of 637 from Escherichia coli K-12 : B3352; ABC transporter ATP-binding protein 4322205 yheS 1080600 yheS Shigella flexneri 2a str. 2457T ABC transporter ATP-binding protein NP_839533.1 4320292 R 198215 CDS NP_839534.1 30065363 1080601 4322336..4322887 1 NC_004741.1 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 4322887 yheR 1080601 yheR Shigella flexneri 2a str. 2457T glutathione-regulated potassium-efflux system ancillary protein KefG NP_839534.1 4322336 D 198215 CDS NP_839535.1 30065364 1080602 4322963..4324624 1 NC_004741.1 involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB 4324624 kefB 1080602 kefB Shigella flexneri 2a str. 2457T glutathione-regulated potassium-efflux system protein KefB NP_839535.1 4322963 D 198215 CDS NP_839536.1 30065365 1080603 4324929..4325519 1 NC_004741.1 rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 4325519 slyD 1080603 slyD Shigella flexneri 2a str. 2457T FKBP-type peptidyl-prolyl cis-trans isomerase NP_839536.1 4324929 D 198215 CDS NP_839537.1 30065366 1080604 complement(4325568..4325786) 1 NC_004741.1 residues 1 to 72 of 72 are 77.77 pct identical to residues 1 to 72 of 72 from Escherichia coli K-12 : B3348; hypothetical protein 4325786 slyX 1080604 slyX Shigella flexneri 2a str. 2457T hypothetical protein NP_839537.1 4325568 R 198215 CDS NP_839538.1 30065367 1080605 4326007..4326819 1 NC_004741.1 rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 4326819 fkpA 1080605 fkpA Shigella flexneri 2a str. 2457T FKBP-type peptidyl-prolyl cis-trans isomerase NP_839538.1 4326007 D 198215 CDS NP_839539.1 30065368 1080606 4326986..4327708 1 NC_004741.1 residues 1 to 240 of 240 are 100.00 pct identical to residues 5 to 244 of 244 from Escherichia coli K-12 : B3346; hypothetical protein 4327708 yheO 1080606 yheO Shigella flexneri 2a str. 2457T hypothetical protein NP_839539.1 4326986 D 198215 CDS NP_839540.1 30065369 1080607 4327708..4328094 1 NC_004741.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 4328094 yheN 1080607 yheN Shigella flexneri 2a str. 2457T sulfur transfer complex subunit TusD NP_839540.1 4327708 D 198215 CDS NP_839541.1 30065370 1080608 4328094..4328453 1 NC_004741.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 4328453 yheM 1080608 yheM Shigella flexneri 2a str. 2457T sulfur relay protein TusC NP_839541.1 4328094 D 198215 CDS NP_839542.1 30065371 1080791 4328461..4328748 1 NC_004741.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 4328748 yheL 1080791 yheL Shigella flexneri 2a str. 2457T sulfur transfer complex subunit TusB NP_839542.1 4328461 D 198215 CDS NP_839543.1 30065372 1080974 4328874..4329248 1 NC_004741.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 4329248 rpsL 1080974 rpsL Shigella flexneri 2a str. 2457T 30S ribosomal protein S12 NP_839543.1 4328874 D 198215 CDS NP_839544.1 30065373 1080609 4329345..4329815 1 NC_004741.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 4329815 rpsG 1080609 rpsG Shigella flexneri 2a str. 2457T 30S ribosomal protein S7 NP_839544.1 4329345 D 198215 CDS NP_839545.1 30065374 1080610 4330060..4332027 1 NC_004741.1 Promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome; elongation factor EF-2 4332027 fusA 1080610 fusA Shigella flexneri 2a str. 2457T elongation factor EF-2 NP_839545.1 4330060 D 198215 CDS NP_839546.1 30065375 1080611 4332098..4333282 1 NC_004741.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4333282 tuf 1080611 tuf Shigella flexneri 2a str. 2457T elongation factor Tu NP_839546.1 4332098 D 198215 CDS NP_839547.1 30065376 1080612 4333465..4333659 1 NC_004741.1 residues 1 to 64 of 64 are 87.50 pct identical to residues 1 to 64 of 64 from Escherichia coli K-12 : B3337; bacterioferritin-associated ferredoxin 4333659 yheA 1080612 yheA Shigella flexneri 2a str. 2457T bacterioferritin-associated ferredoxin NP_839547.1 4333465 D 198215 CDS NP_839548.1 30065377 1080613 4333732..4334208 1 NC_004741.1 iron storage protein; bacterioferritin 4334208 bfr 1080613 bfr Shigella flexneri 2a str. 2457T bacterioferritin NP_839548.1 4333732 D 198215 CDS NP_839549.1 30065378 1080615 4335051..4335362 1 NC_004741.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 4335362 rpsJ 1080615 rpsJ Shigella flexneri 2a str. 2457T 30S ribosomal protein S10 NP_839549.1 4335051 D 198215 CDS NP_839550.1 30065379 1080616 4335395..4336024 1 NC_004741.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 4336024 rplC 1080616 rplC Shigella flexneri 2a str. 2457T 50S ribosomal protein L3 NP_839550.1 4335395 D 198215 CDS NP_839551.1 30065380 1080617 4336035..4336640 1 NC_004741.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 4336640 rplD 1080617 rplD Shigella flexneri 2a str. 2457T 50S ribosomal protein L4 NP_839551.1 4336035 D 198215 CDS NP_839552.1 30065381 1080618 4336637..4336939 1 NC_004741.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 4336939 rplW 1080618 rplW Shigella flexneri 2a str. 2457T 50S ribosomal protein L23 NP_839552.1 4336637 D 198215 CDS NP_839553.1 30065382 1080619 4336957..4337778 1 NC_004741.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 4337778 rplB 1080619 rplB Shigella flexneri 2a str. 2457T 50S ribosomal protein L2 NP_839553.1 4336957 D 198215 CDS NP_839554.1 30065383 1080620 4337795..4338073 1 NC_004741.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 4338073 rpsS 1080620 rpsS Shigella flexneri 2a str. 2457T 30S ribosomal protein S19 NP_839554.1 4337795 D 198215 CDS NP_839555.1 30065384 1080621 4338088..4338420 1 NC_004741.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 4338420 rplV 1080621 rplV Shigella flexneri 2a str. 2457T 50S ribosomal protein L22 NP_839555.1 4338088 D 198215 CDS NP_839556.1 30065385 1080622 4338438..4339139 1 NC_004741.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 4339139 rpsC 1080622 rpsC Shigella flexneri 2a str. 2457T 30S ribosomal protein S3 NP_839556.1 4338438 D 198215 CDS NP_839557.1 30065386 1080623 4339152..4339562 1 NC_004741.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 4339562 rplP 1080623 rplP Shigella flexneri 2a str. 2457T 50S ribosomal protein L16 NP_839557.1 4339152 D 198215 CDS NP_839558.1 30065387 1080624 4339562..4339753 1 NC_004741.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 4339753 rpmC 1080624 rpmC Shigella flexneri 2a str. 2457T 50S ribosomal protein L29 NP_839558.1 4339562 D 198215 CDS NP_839559.1 30065388 1080625 4339753..4340007 1 NC_004741.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 4340007 rpsQ 1080625 rpsQ Shigella flexneri 2a str. 2457T 30S ribosomal protein S17 NP_839559.1 4339753 D 198215 CDS NP_839560.1 30065389 1080626 4340172..4340543 1 NC_004741.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 4340543 rplN 1080626 rplN Shigella flexneri 2a str. 2457T 50S ribosomal protein L14 NP_839560.1 4340172 D 198215 CDS NP_839561.1 30065390 1080627 4340554..4340868 1 NC_004741.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 4340868 rplX 1080627 rplX Shigella flexneri 2a str. 2457T 50S ribosomal protein L24 NP_839561.1 4340554 D 198215 CDS NP_839562.1 30065391 1080628 4340883..4341422 1 NC_004741.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 4341422 rplE 1080628 rplE Shigella flexneri 2a str. 2457T 50S ribosomal protein L5 NP_839562.1 4340883 D 198215 CDS NP_839563.1 30065392 1080629 4341437..4341742 1 NC_004741.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 4341742 rpsN 1080629 rpsN Shigella flexneri 2a str. 2457T 30S ribosomal protein S14 NP_839563.1 4341437 D 198215 CDS NP_839564.1 30065393 1080630 4341776..4342168 1 NC_004741.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 4342168 rpsH 1080630 rpsH Shigella flexneri 2a str. 2457T 30S ribosomal protein S8 NP_839564.1 4341776 D 198215 CDS NP_839565.1 30065394 1080631 4342181..4342714 1 NC_004741.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 4342714 rplF 1080631 rplF Shigella flexneri 2a str. 2457T 50S ribosomal protein L6 NP_839565.1 4342181 D 198215 CDS NP_839566.1 30065395 1080632 4342724..4343077 1 NC_004741.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 4343077 rplR 1080632 rplR Shigella flexneri 2a str. 2457T 50S ribosomal protein L18 NP_839566.1 4342724 D 198215 CDS NP_839567.1 30065396 1080633 4343092..4343595 1 NC_004741.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 4343595 rpsE 1080633 rpsE Shigella flexneri 2a str. 2457T 30S ribosomal protein S5 NP_839567.1 4343092 D 198215 CDS NP_839568.1 30065397 1080634 4343599..4343778 1 NC_004741.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 4343778 rpmD 1080634 rpmD Shigella flexneri 2a str. 2457T 50S ribosomal protein L30 NP_839568.1 4343599 D 198215 CDS NP_839569.1 30065398 1080635 4343782..4344216 1 NC_004741.1 late assembly protein; 50S ribosomal protein L15 4344216 rplO 1080635 rplO Shigella flexneri 2a str. 2457T 50S ribosomal protein L15 NP_839569.1 4343782 D 198215 CDS NP_839570.1 30065399 1080637 4344224..4345555 1 NC_004741.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 4345555 secY 1080637 secY Shigella flexneri 2a str. 2457T preprotein translocase subunit SecY NP_839570.1 4344224 D 198215 CDS NP_839571.1 30065400 1080638 4345587..4345703 1 NC_004741.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 4345703 rpmJ 1080638 rpmJ Shigella flexneri 2a str. 2457T 50S ribosomal protein L36 NP_839571.1 4345587 D 198215 CDS NP_839572.1 30065401 1080639 4345850..4346206 1 NC_004741.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 4346206 rpsM 1080639 rpsM Shigella flexneri 2a str. 2457T 30S ribosomal protein S13 NP_839572.1 4345850 D 198215 CDS NP_839573.1 30065402 1080640 4346223..4346612 1 NC_004741.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 4346612 rpsK 1080640 rpsK Shigella flexneri 2a str. 2457T 30S ribosomal protein S11 NP_839573.1 4346223 D 198215 CDS NP_839574.2 161486375 1080641 4346646..4347266 1 NC_004741.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 4347266 rpsD 1080641 rpsD Shigella flexneri 2a str. 2457T 30S ribosomal protein S4 NP_839574.2 4346646 D 198215 CDS NP_839575.1 30065404 1080642 4347292..4348281 1 NC_004741.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 4348281 rpoA 1080642 rpoA Shigella flexneri 2a str. 2457T DNA-directed RNA polymerase subunit alpha NP_839575.1 4347292 D 198215 CDS NP_839576.1 30065405 1080643 4348322..4348705 1 NC_004741.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 4348705 rplQ 1080643 rplQ Shigella flexneri 2a str. 2457T 50S ribosomal protein L17 NP_839576.1 4348322 D 198215 CDS NP_839577.1 30065406 1080644 4348875..4349549 1 NC_004741.1 residues 1 to 224 of 224 are 100.00 pct identical to residues 1 to 224 of 224 from GenPept : >gb|AAL72464.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfA 4349549 1080644 S4437 Shigella flexneri 2a str. 2457T ISSfl3 orfA NP_839577.1 4348875 D 198215 CDS NP_839578.1 30065407 1080645 4349546..4349896 1 NC_004741.1 residues 1 to 116 of 116 are 100.00 pct identical to residues 1 to 116 of 116 from GenPept : >gb|AAK18528.1|AF348706_217 (AF348706) IS orf [Shigella flexneri]; ISSfl3 orfB 4349896 1080645 S4438 Shigella flexneri 2a str. 2457T ISSfl3 orfB NP_839578.1 4349546 D 198215 CDS NP_839579.1 30065408 1080646 4349893..4350465 1 NC_004741.1 residues 1 to 190 of 190 are 93.15 pct identical to residues 1 to 190 of 190 from GenPept : >gb|AAK18527.1|AF348706_216 (AF348706) IS orf [Shigella flexneri]; ISSfl3 orfC 4350465 1080646 S4439 Shigella flexneri 2a str. 2457T ISSfl3 orfC NP_839579.1 4349893 D 198215 CDS NP_839580.1 30065409 1080647 4350527..4351489 1 NC_004741.1 residues 1 to 320 of 320 are 99.68 pct identical to residues 214 to 533 of 533 from GenPept : >gb|AAL72472.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; ISSfl3 orfD 4351489 1080647 S4440 Shigella flexneri 2a str. 2457T ISSfl3 orfD NP_839580.1 4350527 D 198215 CDS NP_839581.2 161486374 1080648 4351813..4352178 1 NC_004741.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 4352178 1080648 S4441 Shigella flexneri 2a str. 2457T insertion sequence 2 OrfA protein NP_839581.2 4351813 D 198215 CDS NP_839582.2 161486373 1080649 4352136..4353041 1 NC_004741.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4353041 1080649 S4442 Shigella flexneri 2a str. 2457T insertion element IS2 transposase InsD NP_839582.2 4352136 D 198215 CDS NP_839583.2 161486372 1080650 complement(4353240..4353824) 1 NC_004741.1 in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown; RNA 2'-phosphotransferase-like protein 4353824 yjiI 1080650 yjiI Shigella flexneri 2a str. 2457T RNA 2'-phosphotransferase-like protein NP_839583.2 4353240 R 198215 CDS NP_839584.1 30065413 1080651 4354062..4354757 1 NC_004741.1 residues 1 to 231 of 231 are 99.13 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 : B4330; hypothetical protein 4354757 yjiH 1080651 yjiH Shigella flexneri 2a str. 2457T hypothetical protein NP_839584.1 4354062 D 198215 CDS NP_839585.1 30065414 1080652 4354754..4355215 1 NC_004741.1 residues 1 to 153 of 153 are 99.34 pct identical to residues 1 to 153 of 153 from Escherichia coli K-12 : B4329; hypothetical protein 4355215 yjiG 1080652 yjiG Shigella flexneri 2a str. 2457T hypothetical protein NP_839585.1 4354754 D 198215 CDS NP_839586.1 30065415 1080653 4355228..4356400 1 NC_004741.1 residues 1 to 390 of 390 are 99.23 pct identical to residues 1 to 390 of 390 from Escherichia coli K-12 : B4328; isoaspartyl dipeptidase 4356400 iadA 1080653 iadA Shigella flexneri 2a str. 2457T isoaspartyl dipeptidase NP_839586.1 4355228 D 198215 CDS NP_839587.1 30065416 1080654 4356465..4357376 1 NC_004741.1 residues 1 to 303 of 303 are 94.71 pct identical to residues 1 to 303 of 303 from Escherichia coli K-12 : B4327; DNA-binding transcriptional regulator 4357376 yjiE 1080654 yjiE Shigella flexneri 2a str. 2457T DNA-binding transcriptional regulator NP_839587.1 4356465 D 198215 CDS NP_839588.1 30065417 1080655 complement(4357369..4357770) 1 NC_004741.1 residues 1 to 133 of 133 are 99.24 pct identical to residues 1 to 133 of 133 from Escherichia coli K-12 : B4326; hypothetical protein 4357770 yjiD 1080655 yjiD Shigella flexneri 2a str. 2457T hypothetical protein NP_839588.1 4357369 R 198215 CDS NP_839589.1 30065418 1080656 complement(4358047..4358550) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAL72450.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS1 orfB 4358550 1080656 S4449 Shigella flexneri 2a str. 2457T IS1 orfB NP_839589.1 4358047 R 198215 CDS NP_839590.1 30065419 1080657 complement(4358469..4358744) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4358744 1080657 S4450 Shigella flexneri 2a str. 2457T IS1 orfA NP_839590.1 4358469 R 198215 CDS NP_839591.1 30065420 1080659 complement(4360182..4360955) 1 NC_004741.1 regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 4360955 uxuR 1080659 uxuR Shigella flexneri 2a str. 2457T DNA-binding transcriptional repressor UxuR NP_839591.1 4360182 R 198215 CDS NP_839592.1 30065421 1080660 complement(4361170..4362630) 1 NC_004741.1 residues 1 to 486 of 486 are 98.76 pct identical to residues 1 to 486 of 486 from Escherichia coli K-12 : B4323; D-mannonate oxidoreductase 4362630 uxuB 1080660 uxuB Shigella flexneri 2a str. 2457T D-mannonate oxidoreductase NP_839592.1 4361170 R 198215 CDS NP_839593.1 30065422 1080661 complement(4362711..4363895) 1 NC_004741.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 4363895 uxuA 1080661 uxuA Shigella flexneri 2a str. 2457T mannonate dehydratase NP_839593.1 4362711 R 198215 CDS NP_839594.1 30065423 1080662 4364235..4365578 1 NC_004741.1 residues 1 to 447 of 447 are 91.49 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 : B4321; fructuronate transporter 4365578 gntP 1080662 gntP Shigella flexneri 2a str. 2457T fructuronate transporter NP_839594.1 4364235 D 198215 CDS NP_839595.1 30065424 1080663 complement(4365829..4366731) 1 NC_004741.1 residues 1 to 300 of 300 are 99.66 pct identical to residues 1 to 300 of 300 from Escherichia coli K-12 : B4320; minor fimbrial subunit, D-mannose specific adhesin 4366731 fimH 1080663 fimH Shigella flexneri 2a str. 2457T minor fimbrial subunit, D-mannose specific adhesin NP_839595.1 4365829 R 198215 CDS NP_839596.1 30065425 1080664 complement(4366751..4367254) 1 NC_004741.1 residues 1 to 167 of 167 are 99.40 pct identical to residues 1 to 167 of 167 from Escherichia coli K-12 : B4319; minor fimbrial subunit, precursor polypeptide 4367254 fimG 1080664 fimG Shigella flexneri 2a str. 2457T minor fimbrial subunit, precursor polypeptide NP_839596.1 4366751 R 198215 CDS NP_839597.1 30065426 1080665 complement(4367267..4367797) 1 NC_004741.1 residues 1 to 176 of 176 are 97.72 pct identical to residues 1 to 176 of 176 from Escherichia coli K-12 : B4318; minor fimbrial subunit, precursor polypeptide 4367797 fimF 1080665 fimF Shigella flexneri 2a str. 2457T minor fimbrial subunit, precursor polypeptide NP_839597.1 4367267 R 198215 CDS NP_839598.1 30065427 1080667 complement(4369871..4370374) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4370374 1080667 S4460 Shigella flexneri 2a str. 2457T IS1 orfB NP_839598.1 4369871 R 198215 CDS NP_839599.1 30065428 1080668 complement(4370293..4370568) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4370568 1080668 S4461 Shigella flexneri 2a str. 2457T IS1 orfA NP_839599.1 4370293 R 198215 CDS NP_839600.1 30065429 1080669 complement(4371286..4372011) 1 NC_004741.1 residues 1 to 241 of 241 are 99.17 pct identical to residues 1 to 241 of 241 from Escherichia coli K-12 : B4316; required for type 1 fimbriae; periplasmic chaperone 4372011 fimC 1080669 fimC Shigella flexneri 2a str. 2457T periplasmic chaperone NP_839600.1 4371286 R 198215 CDS NP_839601.1 30065430 1080670 complement(4372048..4372686) 1 NC_004741.1 residues 1 to 212 of 212 are 98.11 pct identical to residues 4 to 215 of 215 from Escherichia coli K-12 : B4315; fimbrial protein 4372686 fimI 1080670 fimI Shigella flexneri 2a str. 2457T fimbrial protein NP_839601.1 4372048 R 198215 CDS NP_839602.1 30065431 1080671 complement(4372652..4373200) 1 NC_004741.1 residues 1 to 182 of 182 are 84.06 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 : B4314; major type 1 subunit fimbrin (pilin) 4373200 fimA 1080671 fimA Shigella flexneri 2a str. 2457T major type 1 subunit fimbrin (pilin) NP_839602.1 4372652 R 198215 CDS NP_839603.1 30065432 1080672 complement(4373681..4374277) 1 NC_004741.1 inversion of on/off regulator of fimA; tyrosine recombinase 4374277 fimE 1080672 fimE Shigella flexneri 2a str. 2457T tyrosine recombinase NP_839603.1 4373681 R 198215 CDS NP_839604.1 30065433 1080673 complement(4374872..4375357) 1 NC_004741.1 residues 1 to 160 of 199 are 97.50 pct identical to residues 1 to 160 of 200 from Escherichia coli K-12 : B4312; involved in phase variation; recombinase; regulator for fimA 4375357 fimB 1080673 fimB Shigella flexneri 2a str. 2457T recombinase; regulator for fimA NP_839604.1 4374872 R 198215 CDS NP_839605.1 30065434 1080674 4376979..4377527 1 NC_004741.1 residues 1 to 182 of 182 are 100.00 pct identical to residues 60 to 241 of 241 from Escherichia coli K-12 : B4311; hypothetical protein 4377527 yjhA 1080674 yjhA Shigella flexneri 2a str. 2457T hypothetical protein NP_839605.1 4376979 D 198215 CDS NP_839606.1 30065435 1080675 4377439..4378653 1 NC_004741.1 residues 1 to 404 of 404 are 98.76 pct identical to residues 1 to 404 of 404 from Escherichia coli K-12 : B4310; hypothetical protein 4378653 yjhT 1080675 yjhT Shigella flexneri 2a str. 2457T hypothetical protein NP_839606.1 4377439 D 198215 CDS NP_839607.1 30065436 1080676 4378940..4379698 1 NC_004741.1 residues 1 to 252 of 252 are 99.60 pct identical to residues 75 to 326 of 326 from Escherichia coli K-12 : B4309; hypothetical protein 4379698 yjhS 1080676 yjhS Shigella flexneri 2a str. 2457T hypothetical protein NP_839607.1 4378940 D 198215 CDS NP_839608.1 30065437 1080677 complement(4380167..4380670) 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4380670 1080677 S4471 Shigella flexneri 2a str. 2457T IS1 orfB NP_839608.1 4380167 R 198215 CDS NP_839609.1 30065438 1080678 complement(4380589..4380864) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4380864 1080678 S4472 Shigella flexneri 2a str. 2457T IS1 orfA NP_839609.1 4380589 R 198215 CDS NP_839610.1 30065439 1080679 4380959..4381654 1 NC_004741.1 residues 1 to 231 of 231 are 81.46 pct identical to residues 30 to 261 of 261 from GenPept : >gb|AAL22652.1| (AE008876) regulatory protein, deoR family [Salmonella typhimurium LT2]; DeoR family transcriptional regulator 4381654 1080679 S4473 Shigella flexneri 2a str. 2457T DeoR family transcriptional regulator NP_839610.1 4380959 D 198215 CDS NP_839611.1 30065440 1080680 complement(4381755..4381871) 1 NC_004741.1 residues 4 to 38 of 38 are 88.57 pct identical to residues 29 to 63 of 96 from GenPept : >emb|CAC50649.1| (AX188968) unnamed protein product [Escherichia coli]; hypothetical protein 4381871 1080680 S4474 Shigella flexneri 2a str. 2457T hypothetical protein NP_839611.1 4381755 R 198215 CDS NP_839612.1 30065441 1080681 4382130..4382408 1 NC_004741.1 residues 1 to 92 of 92 are 92.39 pct identical to residues 3 to 94 of 94 from GenPept : >gb|AAG53987.1|AF327445_1 (AF327445) transposase A [Pantoea agglomerans]; ISEhe3a orf 4382408 1080681 S4475 Shigella flexneri 2a str. 2457T ISEhe3a orf NP_839612.1 4382130 D 198215 CDS NP_839613.1 30065442 1080682 4382477..4382779 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 4382779 1080682 S4476 Shigella flexneri 2a str. 2457T IS600 orfA NP_839613.1 4382477 D 198215 CDS NP_839614.1 30065443 1080683 4382920..4383633 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 4383633 1080683 S4477 Shigella flexneri 2a str. 2457T IS600 orfB NP_839614.1 4382920 D 198215 CDS NP_839615.1 30065444 1080685 4384901..4385176 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4385176 1080685 S4479 Shigella flexneri 2a str. 2457T IS1 orfA NP_839615.1 4384901 D 198215 CDS NP_839616.1 30065445 1080686 4385095..4385598 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4385598 1080686 S4480 Shigella flexneri 2a str. 2457T IS1 orfB NP_839616.1 4385095 D 198215 CDS NP_839617.1 30065446 1080687 4385791..4386093 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 13 to 112 of 112 from GenPept : >gb|AAL72382.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS911 orfA 4386093 1080687 S4481 Shigella flexneri 2a str. 2457T IS911 orfA NP_839617.1 4385791 D 198215 CDS NP_839618.1 30065447 1080688 4386333..4386959 1 NC_004741.1 residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; IS911 orfB 4386959 1080688 S4483 Shigella flexneri 2a str. 2457T IS911 orfB NP_839618.1 4386333 D 198215 CDS NP_839619.1 30065448 1080689 complement(4386934..4388145) 1 NC_004741.1 residues 1 to 403 of 403 are 91.58 pct identical to residues 1 to 404 of 431 from NRprotein_Feb03 : >ref|NP_668085.1| prophage P4 integrase [Yersinia pestis KIM] gb|AAM84336.1|AE013677_1 prophage P4 integrase [Yersinia pestis KIM]; P4-type integrase 4388145 1080689 S4839 Shigella flexneri 2a str. 2457T P4-type integrase NP_839619.1 4386934 R 198215 CDS NP_839620.1 30065449 1080691 4388582..4389643 1 NC_004741.1 residues 1 to 353 of 353 are 94.05 pct identical to residues 1 to 353 of 353 from Escherichia coli K-12 : B4269; oxidoreductase 4389643 yjgB 1080691 yjgB Shigella flexneri 2a str. 2457T oxidoreductase NP_839620.1 4388582 D 198215 CDS NP_839621.1 30065450 1080693 4389772..4391286 1 NC_004741.1 residues 1 to 500 of 504 are 94.59 pct identical to residues 1 to 500 of 500 from Escherichia coli K-12 : B4263; hypothetical protein 4391286 yjgR 1080693 yjgR Shigella flexneri 2a str. 2457T hypothetical protein NP_839621.1 4389772 D 198215 CDS NP_839622.1 30065451 1080694 complement(4391394..4392476) 1 NC_004741.1 residues 1 to 360 of 360 are 91.66 pct identical to residues 2 to 361 of 361 from Escherichia coli K-12 : B4262; hypothetical protein 4392476 yjgQ 1080694 yjgQ Shigella flexneri 2a str. 2457T hypothetical protein NP_839622.1 4391394 R 198215 CDS NP_839623.1 30065452 1077860 complement(4392476..4393576) 1 NC_004741.1 residues 1 to 366 of 366 are 86.88 pct identical to residues 1 to 366 of 366 from Escherichia coli K-12 : B4261; hypothetical protein 4393576 yjgP 1077860 yjgP Shigella flexneri 2a str. 2457T hypothetical protein NP_839623.1 4392476 R 198215 CDS NP_839624.1 30065453 1080695 4393843..4395354 1 NC_004741.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 4395354 pepA 1080695 pepA Shigella flexneri 2a str. 2457T leucyl aminopeptidase NP_839624.1 4393843 D 198215 CDS NP_839625.1 30065454 1080696 4395488..4395931 1 NC_004741.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 4395931 holC 1080696 holC Shigella flexneri 2a str. 2457T DNA polymerase III subunit chi NP_839625.1 4395488 D 198215 CDS NP_839626.1 30065455 1080697 4395931..4398786 1 NC_004741.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4398786 valS 1080697 valS Shigella flexneri 2a str. 2457T valyl-tRNA synthetase NP_839626.1 4395931 D 198215 CDS NP_839627.1 30065456 1080698 complement(4398840..4400036) 1 NC_004741.1 residues 1 to 389 of 389 are 87.91 pct identical to residues 5 to 393 of 393 from Escherichia coli K-12 : B4257; hypothetical protein 4400036 yjgN 1080698 yjgN Shigella flexneri 2a str. 2457T hypothetical protein NP_839627.1 4398840 R 198215 CDS NP_839628.1 30065457 1080700 complement(4400775..4401191) 1 NC_004741.1 residues 1 to 119 of 138 are 84.03 pct identical to residues 1 to 119 of 138 from Escherichia coli K-12 : B4255; hypothetical protein 4401191 yjgD 1080700 yjgD Shigella flexneri 2a str. 2457T hypothetical protein NP_839628.1 4400775 R 198215 CDS NP_839629.1 30065458 1080701 4401353..4402366 1 NC_004741.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I 4402366 argI 1080701 argI Shigella flexneri 2a str. 2457T ornithine carbamoyltransferase subunit I NP_839629.1 4401353 D 198215 CDS NP_839630.1 30065459 1080702 4402438..4402713 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4402713 1080702 S4497 Shigella flexneri 2a str. 2457T IS1 orfA NP_839630.1 4402438 D 198215 CDS NP_839631.1 30065460 1080703 4402632..4403135 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4403135 1080703 S4498 Shigella flexneri 2a str. 2457T IS1 orfB NP_839631.1 4402632 D 198215 CDS NP_839632.1 30065461 1080705 complement(4403997..4404449) 1 NC_004741.1 residues 1 to 150 of 150 are 100.00 pct identical to residues 4 to 153 of 153 from Escherichia coli K-12 : B4252; hypothetical protein 4404449 yjgK 1080705 yjgK Shigella flexneri 2a str. 2457T hypothetical protein NP_839632.1 4403997 R 198215 CDS NP_839633.1 30065462 1080706 complement(4404594..4404848) 1 NC_004741.1 residues 1 to 84 of 84 are 94.04 pct identical to residues 1 to 84 of 84 from Escherichia coli K-12 : B4251; hypothetical protein 4404848 yjgJ 1080706 yjgJ Shigella flexneri 2a str. 2457T hypothetical protein NP_839633.1 4404594 R 198215 CDS NP_839634.1 30065463 1080707 complement(4404920..4405075) 1 NC_004741.1 residues 3 to 51 of 51 are 93.87 pct identical to residues 6 to 54 of 54 from Escherichia coli K-12 : B4250; hypothetical protein 4405075 1080707 S4502 Shigella flexneri 2a str. 2457T hypothetical protein NP_839634.1 4404920 R 198215 CDS NP_839635.1 30065464 1080708 4405258..4405971 1 NC_004741.1 residues 1 to 237 of 237 are 93.24 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 : B4249; oxidoreductase 4405971 yjgI 1080708 yjgI Shigella flexneri 2a str. 2457T oxidoreductase NP_839635.1 4405258 D 198215 CDS NP_839636.1 30065465 1080709 4406103..4406498 1 NC_004741.1 residues 1 to 130 of 131 are 98.46 pct identical to residues 1 to 130 of 131 from Escherichia coli K-12 : B4248; hypothetical protein 4406498 yjgH 1080709 yjgH Shigella flexneri 2a str. 2457T hypothetical protein NP_839636.1 4406103 D 198215 CDS NP_839637.1 30065466 1080710 complement(4406467..4406799) 1 NC_004741.1 residues 1 to 110 of 110 are 87.27 pct identical to residues 1 to 110 of 110 from Escherichia coli K-12 : B4247; hypothetical protein 4406799 yjgG 1080710 yjgG Shigella flexneri 2a str. 2457T hypothetical protein NP_839637.1 4406467 R 198215 CDS NP_839638.1 30065467 1080711 4406779..4406913 1 NC_004741.1 residues 1 to 44 of 44 are 97.72 pct identical to residues 1 to 44 of 44 from Escherichia coli K-12 : B4246; pyrBI operon leader peptide 4406913 pyrL 1080711 pyrL Shigella flexneri 2a str. 2457T pyrBI operon leader peptide NP_839638.1 4406779 D 198215 CDS NP_839639.1 30065468 1080712 4406917..4407852 1 NC_004741.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 4407852 pyrB 1080712 pyrB Shigella flexneri 2a str. 2457T aspartate carbamoyltransferase catalytic subunit NP_839639.1 4406917 D 198215 CDS NP_839640.1 30065469 1080713 4407865..4408326 1 NC_004741.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase regulatory subunit 4408326 pyrI 1080713 pyrI Shigella flexneri 2a str. 2457T aspartate carbamoyltransferase regulatory subunit NP_839640.1 4407865 D 198215 CDS NP_839641.1 30065470 1080714 4408360..4408785 1 NC_004741.1 residues 1 to 141 of 141 are 100.00 pct identical to residues 1 to 141 of 141 from Escherichia coli K-12 : B4243; hypothetical protein 4408785 yjgF 1080714 yjgF Shigella flexneri 2a str. 2457T hypothetical protein NP_839641.1 4408360 D 198215 CDS NP_839642.1 30065471 1080715 complement(4408991..4411687) 1 NC_004741.1 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4411687 mgtA 1080715 mgtA Shigella flexneri 2a str. 2457T magnesium-transporting ATPase MgtA NP_839642.1 4408991 R 198215 CDS NP_839643.1 30065472 1080716 4412066..4413013 1 NC_004741.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 4413013 treR 1080716 treR Shigella flexneri 2a str. 2457T trehalose repressor NP_839643.1 4412066 D 198215 CDS NP_839644.1 30065473 1080717 4413135..4414553 1 NC_004741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; trehalose(maltose)-specific PTS system components IIBC 4414553 treB 1080717 treB Shigella flexneri 2a str. 2457T trehalose(maltose)-specific PTS system components IIBC NP_839644.1 4413135 D 198215 CDS NP_839645.1 30065474 1080718 4414603..4416258 1 NC_004741.1 residues 1 to 551 of 551 are 99.45 pct identical to residues 1 to 551 of 551 from Escherichia coli K-12 : B4239; trehalose-6-phosphate hydrolase 4416258 treC 1080718 treC Shigella flexneri 2a str. 2457T trehalose-6-phosphate hydrolase NP_839645.1 4414603 D 198215 CDS NP_839646.1 30065475 1080719 4416652..4418790 1 NC_004741.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 4418790 nrdD 1080719 nrdD Shigella flexneri 2a str. 2457T anaerobic ribonucleoside triphosphate reductase NP_839646.1 4416652 D 198215 CDS NP_839647.1 30065476 1080720 4418948..4419412 1 NC_004741.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 4419412 nrdG 1080720 nrdG Shigella flexneri 2a str. 2457T anaerobic ribonucleotide reductase-activating protein NP_839647.1 4418948 D 198215 CDS NP_839648.1 30065477 1080722 complement(4420022..4421374) 1 NC_004741.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4421374 pmbA 1080722 pmbA Shigella flexneri 2a str. 2457T peptidase PmbA NP_839648.1 4420022 R 198215 CDS NP_839649.1 30065478 1080723 4421468..4422019 1 NC_004741.1 residues 1 to 183 of 183 are 93.44 pct identical to residues 1 to 183 of 183 from Escherichia coli K-12 : B4234; hypothetical protein 4422019 yjgA 1080723 yjgA Shigella flexneri 2a str. 2457T hypothetical protein NP_839649.1 4421468 D 198215 CDS NP_839650.1 30065479 1080724 complement(4422102..4423475) 1 NC_004741.1 residues 1 to 457 of 457 are 99.78 pct identical to residues 1 to 457 of 457 from Escherichia coli K-12 : B4233; ligase 4423475 yjfG 1080724 yjfG Shigella flexneri 2a str. 2457T ligase NP_839650.1 4422102 R 198215 CDS NP_839651.1 30065480 1080725 4423651..4424649 1 NC_004741.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 4424649 fbp 1080725 fbp Shigella flexneri 2a str. 2457T fructose-1,6-bisphosphatase NP_839651.1 4423651 D 198215 CDS NP_839652.1 30065481 1080728 complement(4424687..4426015) 1 NC_004741.1 residues 1 to 442 of 442 are 99.77 pct identical to residues 7 to 448 of 448 from GenPept : >gb|AAK18333.1|AF348706_22 (AF348706) IS4 orf [Shigella flexneri]; IS4 orf 4426015 1080728 S4521 Shigella flexneri 2a str. 2457T IS4 orf NP_839652.1 4424687 R 198215 CDS NP_839653.1 30065482 1080730 complement(4427102..4428127) 1 NC_004741.1 residues 1 to 341 of 341 are 71.84 pct identical to residues 1 to 341 of 341 from Escherichia coli K-12 : B4230; transport system permease 4428127 ytfT 1080730 ytfT Shigella flexneri 2a str. 2457T transport system permease NP_839653.1 4427102 R 198215 CDS NP_839654.1 30065483 1080733 complement(4428138..4429640) 1 NC_004741.1 residues 1 to 381 of 500 are 95.80 pct identical to residues 1 to 381 of 417 from Escherichia coli K-12 : B4228; ATP-binding component of a transport system 4429640 ytfR 1080733 ytfR Shigella flexneri 2a str. 2457T ATP-binding component of a transport system NP_839654.1 4428138 R 198215 CDS NP_839655.1 30065484 1080735 4431046..4431576 1 NC_004741.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 4431576 ppa 1080735 ppa Shigella flexneri 2a str. 2457T inorganic pyrophosphatase NP_839655.1 4431046 D 198215 CDS NP_839656.1 30065485 1080736 4431952..4432215 1 NC_004741.1 residues 1 to 87 of 87 are 96.55 pct identical to residues 3 to 89 of 89 from Escherichia coli K-12 : B4223; hypothetical protein 4432215 yjfA 1080736 yjfA Shigella flexneri 2a str. 2457T hypothetical protein NP_839656.1 4431952 D 198215 CDS NP_839657.1 30065486 1080737 complement(4431956..4432297) 1 NC_004741.1 residues 1 to 113 of 113 are 100.00 pct identical to residues 1 to 113 of 113 from Escherichia coli K-12 : B4222; hypothetical protein 4432297 ytfP 1080737 ytfP Shigella flexneri 2a str. 2457T hypothetical protein NP_839657.1 4431956 R 198215 CDS NP_839658.1 30065487 1080738 complement(4432300..4436079) 1 NC_004741.1 residues 1 to 1259 of 1259 are 94.91 pct identical to residues 1 to 1259 of 1259 from Escherichia coli K-12 : B4221; hypothetical protein 4436079 ytfN 1080738 ytfN Shigella flexneri 2a str. 2457T hypothetical protein NP_839658.1 4432300 R 198215 CDS NP_839659.1 30065488 1080739 complement(4436076..4437809) 1 NC_004741.1 residues 1 to 577 of 577 are 96.88 pct identical to residues 1 to 577 of 577 from Escherichia coli K-12 : B4220; hypothetical protein 4437809 ytfM 1080739 ytfM Shigella flexneri 2a str. 2457T hypothetical protein NP_839659.1 4436076 R 198215 CDS NP_839660.1 30065489 1080740 4438015..4438653 1 NC_004741.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 4438653 msrA 1080740 msrA Shigella flexneri 2a str. 2457T methionine sulfoxide reductase A NP_839660.1 4438015 D 198215 CDS NP_839661.1 30065490 1080741 4438976..4440319 1 NC_004741.1 residues 1 to 447 of 447 are 97.09 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 : B4218; transporter 4440319 ytfL 1080741 ytfL Shigella flexneri 2a str. 2457T transporter NP_839661.1 4438976 D 198215 CDS NP_839662.1 30065491 1080742 complement(4440381..4440626) 1 NC_004741.1 residues 1 to 81 of 81 are 98.37 pct identical to residues 1 to 81 of 81 from Escherichia coli K-12 : B4217; hypothetical protein 4440626 ytfK 1080742 ytfK Shigella flexneri 2a str. 2457T hypothetical protein NP_839662.1 4440381 R 198215 CDS NP_839663.1 30065492 1077112 4440912..4441466 1 NC_004741.1 residues 1 to 184 of 184 are 98.36 pct identical to residues 1 to 184 of 184 from Escherichia coli K-12 : B4216; hypothetical protein 4441466 ytfJ 1077112 ytfJ Shigella flexneri 2a str. 2457T hypothetical protein NP_839663.1 4440912 D 198215 CDS NP_839664.1 30065493 1080744 complement(4442679..4443419) 1 NC_004741.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4443419 cysQ 1080744 cysQ Shigella flexneri 2a str. 2457T adenosine-3'(2'),5'-bisphosphate nucleotidase NP_839664.1 4442679 R 198215 CDS NP_839665.1 30065494 1080745 4443609..4445552 1 NC_004741.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein 4445552 cpdB 1080745 cpdB Shigella flexneri 2a str. 2457T bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein NP_839665.1 4443609 D 198215 CDS NP_839666.1 30065495 1080749 complement(4445678..4446148) 1 NC_004741.1 residues 1 to 156 of 156 are 100.00 pct identical to residues 1 to 156 of 156 from Escherichia coli K-12 : B4212; hypothetical protein 4446148 ytfH 1080749 ytfH Shigella flexneri 2a str. 2457T hypothetical protein NP_839666.1 4445678 R 198215 CDS NP_839667.1 30065496 1077990 4446147..4447007 1 NC_004741.1 residues 1 to 286 of 286 are 93.70 pct identical to residues 1 to 286 of 286 from Escherichia coli K-12 : B4211; oxidoreductase 4447007 ytfG 1077990 ytfG Shigella flexneri 2a str. 2457T oxidoreductase NP_839667.1 4446147 D 198215 CDS NP_839668.1 30065497 1080750 4447116..4448081 1 NC_004741.1 residues 1 to 321 of 321 are 95.01 pct identical to residues 4 to 324 of 324 from Escherichia coli K-12 : B4210; transmembrane subunit 4448081 ytfF 1080750 ytfF Shigella flexneri 2a str. 2457T transmembrane subunit NP_839668.1 4447116 D 198215 CDS NP_839669.1 30065498 1080751 4448189..4448851 1 NC_004741.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 4448851 ytfE 1080751 ytfE Shigella flexneri 2a str. 2457T iron-sulfur cluster repair di-iron protein NP_839669.1 4448189 D 198215 CDS NP_839670.1 30065499 1080753 complement(4448896..4450308) 1 NC_004741.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4450308 cycA 1080753 cycA Shigella flexneri 2a str. 2457T D-alanine/D-serine/glycine permease NP_839670.1 4448896 R 198215 CDS NP_839671.1 30065500 1080754 4451419..4452000 1 NC_004741.1 residues 1 to 193 of 193 are 68.75 pct identical to residues 1 to 224 of 224 from Escherichia coli K-12 : B4206; hypothetical protein 4452000 ytfB 1080754 ytfB Shigella flexneri 2a str. 2457T hypothetical protein NP_839671.1 4451419 D 198215 CDS NP_839672.1 30065501 1079030 complement(4451984..4452310) 1 NC_004741.1 residues 1 to 108 of 108 are 98.14 pct identical to residues 1 to 108 of 108 from Escherichia coli K-12 : B4205; hypothetical protein 4452310 ytfA 1079030 ytfA Shigella flexneri 2a str. 2457T hypothetical protein NP_839672.1 4451984 R 198215 CDS NP_839673.1 30065502 1080755 4452843..4453634 1 NC_004741.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 4453634 fabG 1080755 fabG Shigella flexneri 2a str. 2457T 3-ketoacyl-ACP reductase NP_839673.1 4452843 D 198215 CDS NP_839674.1 30065503 1077714 4453644..4454528 1 NC_004741.1 residues 1 to 294 of 294 are 99.65 pct identical to residues 1 to 294 of 294 from GenPept : >gb|AAL50626.1|AF417476_3 (AF417476) unknown [Shigella flexneri]; hypothetical protein 4454528 1077714 S4548 Shigella flexneri 2a str. 2457T hypothetical protein NP_839674.1 4453644 D 198215 CDS NP_839675.1 30065504 1080756 complement(4454463..4454966) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 4454966 1080756 S4549 Shigella flexneri 2a str. 2457T IS1 orfB NP_839675.1 4454463 R 198215 CDS NP_839676.1 30065505 1080757 complement(4454885..4455160) 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4455160 1080757 S4550 Shigella flexneri 2a str. 2457T IS1 orfA NP_839676.1 4454885 R 198215 CDS NP_839677.1 30065506 1080758 4455218..4456036 1 NC_004741.1 residues 1 to 272 of 272 are 91.54 pct identical to residues 1 to 272 of 272 from GenPept : >gb|AAL72453.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfB 4456036 1080758 S4551 Shigella flexneri 2a str. 2457T IS600 orfB NP_839677.1 4455218 D 198215 CDS NP_839678.1 30065507 1080759 complement(4456077..4457129) 1 NC_004741.1 residues 1 to 350 of 350 are 94.85 pct identical to residues 1 to 350 of 444 from Escherichia coli K-12 : B4132; transport of lysine/cadaverine 4457129 1080759 S4552 Shigella flexneri 2a str. 2457T transport of lysine/cadaverine NP_839678.1 4456077 R 198215 CDS NP_839679.1 30065508 1080760 4457304..4457579 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4457579 1080760 S4553 Shigella flexneri 2a str. 2457T IS1 orfA NP_839679.1 4457304 D 198215 CDS NP_839680.1 30065509 1080761 4457498..4458001 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4458001 1080761 S4554 Shigella flexneri 2a str. 2457T IS1 orfB NP_839680.1 4457498 D 198215 CDS NP_839681.1 30065510 1080763 complement(4458546..4459121) 1 NC_004741.1 residues 1 to 191 of 191 are 99.47 pct identical to residues 9 to 199 of 199 from Escherichia coli K-12 : B4135; transcriptional regulator 4459121 yjdC 1080763 yjdC Shigella flexneri 2a str. 2457T transcriptional regulator NP_839681.1 4458546 R 198215 CDS NP_839682.1 30065511 1080764 complement(4459158..4460855) 1 NC_004741.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein precursor 4460855 dipZ 1080764 dipZ Shigella flexneri 2a str. 2457T thiol:disulfide interchange protein precursor NP_839682.1 4459158 R 198215 CDS NP_839683.1 30065512 1080765 complement(4460831..4461169) 1 NC_004741.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 4461169 cutA 1080765 cutA Shigella flexneri 2a str. 2457T divalent-cation tolerance protein CutA NP_839683.1 4460831 R 198215 CDS NP_839684.1 30065513 1080766 complement(4461285..4462586) 1 NC_004741.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 4462586 dcuA 1080766 dcuA Shigella flexneri 2a str. 2457T anaerobic C4-dicarboxylate transporter NP_839684.1 4461285 R 198215 CDS NP_839685.1 30065514 1080767 complement(4462704..4464185) 1 NC_004741.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 4464185 aspA 1080767 aspA Shigella flexneri 2a str. 2457T aspartate ammonia-lyase NP_839685.1 4462704 R 198215 CDS NP_839686.2 161486371 1080768 4464477..4464953 1 NC_004741.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA 4464953 fxsA 1080768 fxsA Shigella flexneri 2a str. 2457T FxsA NP_839686.2 4464477 D 198215 CDS NP_839687.1 30065516 1080769 complement(4464969..4466225) 1 NC_004741.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; inner membrane protein YjeH 4466225 yjeH 1080769 yjeH Shigella flexneri 2a str. 2457T inner membrane protein YjeH NP_839687.1 4464969 R 198215 CDS NP_839688.1 30065517 1080771 4466501..4466794 1 NC_004741.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4466794 groES 1080771 groES Shigella flexneri 2a str. 2457T co-chaperonin GroES NP_839688.1 4466501 D 198215 CDS NP_839689.1 30065518 1080772 4466838..4468484 1 NC_004741.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 4468484 groEL 1080772 groEL Shigella flexneri 2a str. 2457T chaperonin GroEL NP_839689.1 4466838 D 198215 CDS NP_839690.1 30065519 1080773 4468589..4468975 1 NC_004741.1 residues 1 to 128 of 128 are 100.00 pct identical to residues 1 to 128 of 128 from Escherichia coli K-12 : B4144; hypothetical protein 4468975 yjeI 1080773 yjeI Shigella flexneri 2a str. 2457T hypothetical protein NP_839690.1 4468589 D 198215 CDS NP_839691.1 30065520 1080774 complement(4469178..4470047) 1 NC_004741.1 residues 1 to 289 of 289 are 99.65 pct identical to residues 1 to 289 of 289 from Escherichia coli K-12 : B4145; hypothetical protein 4470047 yjeJ 1080774 yjeJ Shigella flexneri 2a str. 2457T hypothetical protein NP_839691.1 4469178 R 198215 CDS NP_839692.1 30065521 1080775 4470233..4470508 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4470508 1080775 S4567 Shigella flexneri 2a str. 2457T IS1 orfA NP_839692.1 4470233 D 198215 CDS NP_839693.1 30065522 1080776 4470427..4470930 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4470930 1080776 S4568 Shigella flexneri 2a str. 2457T IS1 orfB NP_839693.1 4470427 D 198215 CDS NP_839694.1 30065523 1080777 complement(4471209..4472237) 1 NC_004741.1 residues 1 to 342 of 342 are 98.24 pct identical to residues 1 to 342 of 342 from Escherichia coli K-12 : B4146; hypothetical protein 4472237 yjeK 1080777 yjeK Shigella flexneri 2a str. 2457T hypothetical protein NP_839694.1 4471209 R 198215 CDS NP_839695.1 30065524 1080778 4472279..4472845 1 NC_004741.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4472845 efp 1080778 efp Shigella flexneri 2a str. 2457T elongation factor P NP_839695.1 4472279 D 198215 CDS NP_839696.1 30065525 1080779 4473305..4473772 1 NC_004741.1 residues 1 to 155 of 155 are 87.09 pct identical to residues 1 to 155 of 155 from Escherichia coli K-12 : B4148; may be a chaperone; suppresser of groEL 4473772 sugE 1080779 sugE Shigella flexneri 2a str. 2457T suppresser of groEL NP_839696.1 4473305 D 198215 CDS NP_839697.1 30065526 1077869 complement(4473769..4474302) 1 NC_004741.1 lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 4474302 blc 1077869 blc Shigella flexneri 2a str. 2457T outer membrane lipoprotein Blc NP_839697.1 4473769 R 198215 CDS NP_839698.1 30065527 1080780 complement(4474391..4475524) 1 NC_004741.1 residues 1 to 377 of 377 are 98.14 pct identical to residues 1 to 377 of 377 from Escherichia coli K-12 : B4150; involved in penicillin resistance; beta-lactamase 4475524 ampC 1080780 ampC Shigella flexneri 2a str. 2457T beta-lactamase NP_839698.1 4474391 R 198215 CDS NP_839699.1 30065528 1080781 complement(4475587..4475946) 1 NC_004741.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 4475946 frdD 1080781 frdD Shigella flexneri 2a str. 2457T fumarate reductase subunit D NP_839699.1 4475587 R 198215 CDS NP_839700.1 30065529 1080782 complement(4475957..4476352) 1 NC_004741.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 4476352 frdC 1080782 frdC Shigella flexneri 2a str. 2457T fumarate reductase subunit C NP_839700.1 4475957 R 198215 CDS NP_839701.1 30065530 1080783 complement(4476363..4477097) 1 NC_004741.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 4477097 frdB 1080783 frdB Shigella flexneri 2a str. 2457T fumarate reductase iron-sulfur subunit NP_839701.1 4476363 R 198215 CDS NP_839702.1 30065531 1080784 complement(4477090..4478898) 1 NC_004741.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 4478898 frdA 1080784 frdA Shigella flexneri 2a str. 2457T fumarate reductase flavoprotein subunit NP_839702.1 4477090 R 198215 CDS NP_839703.1 30065532 1080785 4479223..4480200 1 NC_004741.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4480200 yjeA 1080785 yjeA Shigella flexneri 2a str. 2457T lysyl-tRNA synthetase NP_839703.1 4479223 D 198215 CDS NP_839704.1 30065533 1080786 complement(4480989..4481264) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4481264 1080786 S4579 Shigella flexneri 2a str. 2457T IS1 orfA NP_839704.1 4480989 R 198215 CDS NP_839705.1 30065534 1080788 complement(4482805..4486116) 1 NC_004741.1 residues 1 to 1103 of 1103 are 95.39 pct identical to residues 1 to 1107 of 1107 from Escherichia coli K-12 : B4159; hypothetical protein 4486116 yjeP 1080788 yjeP Shigella flexneri 2a str. 2457T hypothetical protein NP_839705.1 4482805 R 198215 CDS NP_839706.1 30065535 1080976 complement(4486138..4487106) 1 NC_004741.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 4487106 psd 1080976 psd Shigella flexneri 2a str. 2457T phosphatidylserine decarboxylase NP_839706.1 4486138 R 198215 CDS NP_839707.2 161486370 1080789 complement(4487203..4488255) 1 NC_004741.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 4488255 yjeQ 1080789 yjeQ Shigella flexneri 2a str. 2457T ribosome-associated GTPase NP_839707.2 4487203 R 198215 CDS NP_839708.2 161486369 1080906 4488350..4488895 1 NC_004741.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4488895 yjeR 1080906 yjeR Shigella flexneri 2a str. 2457T oligoribonuclease NP_839708.2 4488350 D 198215 CDS NP_839709.1 30065538 1080795 complement(4489906..4491045) 1 NC_004741.1 residues 1 to 379 of 379 are 99.47 pct identical to residues 1 to 379 of 379 from Escherichia coli K-12 : B4166; hypothetical protein 4491045 yjeS 1080795 yjeS Shigella flexneri 2a str. 2457T hypothetical protein NP_839709.1 4489906 R 198215 CDS NP_839710.1 30065539 1077769 4491044..4492591 1 NC_004741.1 residues 1 to 515 of 515 are 92.42 pct identical to residues 1 to 515 of 515 from Escherichia coli K-12 : B4167; hypothetical protein 4492591 yjeF 1077769 yjeF Shigella flexneri 2a str. 2457T hypothetical protein NP_839710.1 4491044 D 198215 CDS NP_839711.1 30065540 1080796 4492563..4493024 1 NC_004741.1 possibly involved in cell wall synthesis; ATPase 4493024 yjeE 1080796 yjeE Shigella flexneri 2a str. 2457T ATPase NP_839711.1 4492563 D 198215 CDS NP_839712.1 30065541 1080911 4493043..4494380 1 NC_004741.1 residues 1 to 445 of 445 are 93.48 pct identical to residues 1 to 445 of 445 from Escherichia coli K-12 : B4169; N-acetylmuramoyl-l-alanine amidase II 4494380 amiB 1080911 amiB Shigella flexneri 2a str. 2457T N-acetylmuramoyl-l-alanine amidase II NP_839712.1 4493043 D 198215 CDS NP_839713.1 30065542 1080798 4494390..4496237 1 NC_004741.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4496237 mutL 1080798 mutL Shigella flexneri 2a str. 2457T DNA mismatch repair protein NP_839713.1 4494390 D 198215 CDS NP_839714.1 30065543 1079793 4496230..4497180 1 NC_004741.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4497180 miaA 1079793 miaA Shigella flexneri 2a str. 2457T tRNA delta(2)-isopentenylpyrophosphate transferase NP_839714.1 4496230 D 198215 CDS NP_839715.1 30065544 1080960 4497266..4497574 1 NC_004741.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4497574 hfq 1080960 hfq Shigella flexneri 2a str. 2457T RNA-binding protein Hfq NP_839715.1 4497266 D 198215 CDS NP_839716.1 30065545 1080799 4497650..4498930 1 NC_004741.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 4498930 hflX 1080799 hflX Shigella flexneri 2a str. 2457T GTPase HflX NP_839716.1 4497650 D 198215 CDS NP_839717.1 30065546 1080800 4499016..4500275 1 NC_004741.1 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4500275 hflK 1080800 hflK Shigella flexneri 2a str. 2457T FtsH protease regulator HflK NP_839717.1 4499016 D 198215 CDS NP_839718.1 30065547 1080801 4500278..4501282 1 NC_004741.1 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4501282 hflC 1080801 hflC Shigella flexneri 2a str. 2457T FtsH protease regulator HflC NP_839718.1 4500278 D 198215 CDS NP_839719.1 30065548 1078110 4501364..4501561 1 NC_004741.1 residues 1 to 65 of 65 are 63.07 pct identical to residues 1 to 65 of 65 from Escherichia coli K-12 : B4176; hypothetical protein 4501561 yjeT 1078110 yjeT Shigella flexneri 2a str. 2457T hypothetical protein NP_839719.1 4501364 D 198215 CDS NP_839720.1 30065549 1080802 4501665..4502963 1 NC_004741.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4502963 purA 1080802 purA Shigella flexneri 2a str. 2457T adenylosuccinate synthetase NP_839720.1 4501665 D 198215 CDS NP_839721.1 30065550 1080926 4503168..4503593 1 NC_004741.1 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4503593 yjeB 1080926 yjeB Shigella flexneri 2a str. 2457T transcriptional repressor NsrR NP_839721.1 4503168 D 198215 CDS NP_839722.2 161486368 1080803 4503632..4506073 1 NC_004741.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4506073 vacB 1080803 vacB Shigella flexneri 2a str. 2457T exoribonuclease R NP_839722.2 4503632 D 198215 CDS NP_839723.1 30065552 1080804 4506253..4506984 1 NC_004741.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4506984 yjfH 1080804 yjfH Shigella flexneri 2a str. 2457T 23S rRNA (guanosine-2'-O-)-methyltransferase NP_839723.1 4506253 D 198215 CDS NP_839724.1 30065553 1080806 4507085..4507360 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4507360 1080806 S4604 Shigella flexneri 2a str. 2457T IS1 orfA NP_839724.1 4507085 D 198215 CDS NP_839725.1 30065554 1080807 4507279..4507782 1 NC_004741.1 residues 1 to 167 of 167 are 89.82 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4507782 1080807 S4605 Shigella flexneri 2a str. 2457T IS1 orfB NP_839725.1 4507279 D 198215 CDS NP_839726.1 30065555 1080809 4508048..4508686 1 NC_004741.1 residues 1 to 212 of 212 are 74.05 pct identical to residues 1 to 212 of 212 from Escherichia coli K-12 : B4185; hypothetical protein 4508686 yjfM 1080809 yjfM Shigella flexneri 2a str. 2457T hypothetical protein NP_839726.1 4508048 D 198215 CDS NP_839727.1 30065556 1080810 4508689..4509852 1 NC_004741.1 residues 1 to 387 of 387 are 94.83 pct identical to residues 1 to 387 of 387 from Escherichia coli K-12 : B4186; synthetase/amidase 4509852 yjfC 1080810 yjfC Shigella flexneri 2a str. 2457T synthetase/amidase NP_839727.1 4508689 D 198215 CDS NP_839728.1 30065557 1080812 complement(4511235..4511738) 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4511738 1080812 S4610 Shigella flexneri 2a str. 2457T IS1 orfB NP_839728.1 4511235 R 198215 CDS NP_839729.1 30065558 1080792 complement(4511657..4511932) 1 NC_004741.1 residues 1 to 91 of 91 are 98.90 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4511932 1080792 S4611 Shigella flexneri 2a str. 2457T IS1 orfA NP_839729.1 4511657 R 198215 CDS NP_839730.1 30065559 1080813 complement(4512455..4512757) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from Escherichia coli K-12 : B4188; hypothetical protein 4512757 yjfN 1080813 yjfN Shigella flexneri 2a str. 2457T hypothetical protein NP_839730.1 4512455 R 198215 CDS NP_839731.2 161486367 1080814 complement(4512879..4513208) 1 NC_004741.1 residues 1 to 142 of 142 are 87.32 pct identical to residues 1 to 142 of 142 from Escherichia coli K-12 : B4189; hypothetical protein 4513208 yjfO 1080814 yjfO Shigella flexneri 2a str. 2457T hypothetical protein NP_839731.2 4512879 R 198215 CDS NP_839732.1 30065561 1080815 4513390..4514139 1 NC_004741.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4514139 yjfP 1080815 yjfP Shigella flexneri 2a str. 2457T esterase NP_839732.1 4513390 D 198215 CDS NP_839733.1 30065562 1080816 complement(4514136..4514891) 1 NC_004741.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 4514891 yjfQ 1080816 yjfQ Shigella flexneri 2a str. 2457T transcriptional repressor UlaR NP_839733.1 4514136 R 198215 CDS NP_839734.1 30065563 1080817 complement(4514999..4516069) 1 NC_004741.1 residues 1 to 356 of 356 are 96.34 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 : B4192; L-ascorbate 6-phosphate lactonase 4516069 yjfR 1080817 yjfR Shigella flexneri 2a str. 2457T L-ascorbate 6-phosphate lactonase NP_839734.1 4514999 R 198215 CDS NP_839735.2 161486366 1080818 4516418..4517815 1 NC_004741.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; ascorbate-specific PTS system enzyme IIC 4517815 ulaA 1080818 ulaA Shigella flexneri 2a str. 2457T ascorbate-specific PTS system enzyme IIC NP_839735.2 4516418 D 198215 CDS NP_839736.1 30065565 1080819 4517831..4518136 1 NC_004741.1 residues 1 to 101 of 101 are 99.00 pct identical to residues 1 to 101 of 101 from Escherichia coli K-12 : B4194; L-ascorbate-specific enzyme IIB component of PTS 4518136 sgaB 1080819 sgaB Shigella flexneri 2a str. 2457T L-ascorbate-specific enzyme IIB component of PTS NP_839736.1 4517831 D 198215 CDS NP_839737.1 30065566 1080820 4518146..4518610 1 NC_004741.1 residues 1 to 154 of 154 are 95.45 pct identical to residues 1 to 154 of 154 from Escherichia coli K-12 : B4195; L-ascorbate-specific enzyme IIA component of PTS 4518610 ptxA 1080820 ptxA Shigella flexneri 2a str. 2457T L-ascorbate-specific enzyme IIA component of PTS NP_839737.1 4518146 D 198215 CDS NP_839738.1 30065567 1080821 4518624..4519274 1 NC_004741.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4519274 ulaD 1080821 ulaD Shigella flexneri 2a str. 2457T 3-keto-L-gulonate-6-phosphate decarboxylase NP_839738.1 4518624 D 198215 CDS NP_839739.1 30065568 1080822 4519284..4520138 1 NC_004741.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4520138 sgaU 1080822 sgaU Shigella flexneri 2a str. 2457T L-xylulose 5-phosphate 3-epimerase NP_839739.1 4519284 D 198215 CDS NP_839740.1 30065569 1080823 4520138..4520824 1 NC_004741.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4520824 sgaE 1080823 sgaE Shigella flexneri 2a str. 2457T L-ribulose-5-phosphate 4-epimerase NP_839740.1 4520138 D 198215 CDS NP_839741.1 30065570 1080824 complement(4520953..4521228) 1 NC_004741.1 residues 1 to 91 of 91 are 89.01 pct identical to residues 1 to 91 of 91 from Escherichia coli K-12 : B4199; hypothetical protein 4521228 yjfY 1080824 yjfY Shigella flexneri 2a str. 2457T hypothetical protein NP_839741.1 4520953 R 198215 CDS NP_839742.1 30065571 1080825 4521555..4521950 1 NC_004741.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4521950 rpsF 1080825 rpsF Shigella flexneri 2a str. 2457T 30S ribosomal protein S6 NP_839742.1 4521555 D 198215 CDS NP_839743.1 30065572 1080826 4521957..4522271 1 NC_004741.1 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4522271 priB 1080826 priB Shigella flexneri 2a str. 2457T primosomal replication protein N NP_839743.1 4521957 D 198215 CDS NP_839744.1 30065573 1077861 4522276..4522503 1 NC_004741.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4522503 rpsR 1077861 rpsR Shigella flexneri 2a str. 2457T 30S ribosomal protein S18 NP_839744.1 4522276 D 198215 CDS NP_839745.1 30065574 1080827 4522545..4522994 1 NC_004741.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4522994 rplI 1080827 rplI Shigella flexneri 2a str. 2457T 50S ribosomal protein L9 NP_839745.1 4522545 D 198215 CDS NP_839746.1 30065575 1080828 4523692..4523970 1 NC_004741.1 residues 1 to 92 of 92 are 92.39 pct identical to residues 3 to 94 of 94 from GenPept : >gb|AAG53987.1|AF327445_1 (AF327445) transposase A [Pantoea agglomerans]; ISEhe3 orfA 4523970 1080828 S4629 Shigella flexneri 2a str. 2457T ISEhe3 orfA NP_839746.1 4523692 D 198215 CDS NP_839747.1 30065576 1080829 4524027..4524608 1 NC_004741.1 residues 1 to 193 of 193 are 95.85 pct identical to residues 10 to 202 of 279 from GenPept : >gb|AAG53988.1|AF327445_2 (AF327445) transposase B [Pantoea agglomerans]; ISEhe3 orfB 4524608 1080829 S4630 Shigella flexneri 2a str. 2457T ISEhe3 orfB NP_839747.1 4524027 D 198215 CDS NP_839748.1 30065577 1080830 complement(4524649..4525362) 1 NC_004741.1 residues 1 to 237 of 237 are 91.13 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 4525362 1080830 S4631 Shigella flexneri 2a str. 2457T IS600 orfB NP_839748.1 4524649 R 198215 CDS NP_839749.1 30065578 1080831 complement(4525503..4525805) 1 NC_004741.1 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAL72452.1| (AF386526) hypothetical protein [Shigella flexneri 2a]; IS600 orfA 4525805 1080831 S4632 Shigella flexneri 2a str. 2457T IS600 orfA NP_839749.1 4525503 R 198215 CDS NP_839750.1 30065579 1080832 4525870..4526190 1 NC_004741.1 residues 1 to 106 of 106 are 98.11 pct identical to residues 282 to 387 of 387 from GenPept : >gb|AAG59527.1|AE005665_9 (AE005665) orf; conserved hypothetical protein [Escherichia coli O157:H7 EDL933]; hypothetical protein 4526190 1080832 S4633 Shigella flexneri 2a str. 2457T hypothetical protein NP_839750.1 4525870 D 198215 CDS NP_839751.1 30065580 1080834 complement(4526799..4528454) 1 NC_004741.1 residues 1 to 551 of 551 are 51.70 pct identical to residues 1 to 584 of 584 from GenPept : >gb|AAG59529.1|AE005666_1 (AE005666) restriction modification enzyme S subunit [Escherichia coli O157:H7 EDL933]; hypothetical protein 4528454 1080834 S4635 Shigella flexneri 2a str. 2457T hypothetical protein NP_839751.1 4526799 R 198215 CDS NP_839752.1 30065581 1080837 4532719..4532994 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4532994 1080837 S4638 Shigella flexneri 2a str. 2457T IS1 orfA NP_839752.1 4532719 D 198215 CDS NP_839753.1 30065582 1080838 4532913..4533416 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAD44742.1|AF141323_13 (AF141323) TnpH [Shigella flexneri]; IS1 orfB 4533416 1080838 S4639 Shigella flexneri 2a str. 2457T IS1 orfB NP_839753.1 4532913 D 198215 CDS NP_839754.1 30065583 1080839 complement(4534262..4535116) 1 NC_004741.1 residues 1 to 284 of 284 are 93.66 pct identical to residues 1 to 284 of 284 from Escherichia coli K-12 : B4352; GTP-binding protein YjiA 4535116 yjiA 1080839 yjiA Shigella flexneri 2a str. 2457T GTP-binding protein YjiA NP_839754.1 4534262 R 198215 CDS NP_839755.1 30065584 1080840 complement(4535229..4535432) 1 NC_004741.1 residues 1 to 67 of 67 are 100.00 pct identical to residues 1 to 67 of 67 from Escherichia coli K-12 : B4353; hypothetical protein 4535432 yjiX 1080840 yjiX Shigella flexneri 2a str. 2457T hypothetical protein NP_839755.1 4535229 R 198215 CDS NP_839756.1 30065585 1080841 complement(4535482..4537647) 1 NC_004741.1 residues 1 to 721 of 721 are 87.65 pct identical to residues 1 to 721 of 721 from Escherichia coli K-12 : B4354; carbon starvation protein 4537647 yjiY 1080841 yjiY Shigella flexneri 2a str. 2457T carbon starvation protein NP_839756.1 4535482 R 198215 CDS NP_839757.1 30065586 1080842 complement(4538025..4538537) 1 NC_004741.1 residues 1 to 170 of 170 are 99.41 pct identical to residues 1 to 170 of 170 from GenPept : >emb|CAA86049.2| (Z37980) component C of the 4HPA-hydroxylase [Escherichia coli]; component C of the 4HPA-hydroxylase 4538537 hpaC 1080842 hpaC Shigella flexneri 2a str. 2457T component C of the 4HPA-hydroxylase NP_839757.1 4538025 R 198215 CDS NP_839758.1 30065587 1080844 complement(4540366..4541133) 1 NC_004741.1 residues 2 to 243 of 255 are 83.47 pct identical to residues 53 to 294 of 312 from GenPept : >emb|CAD08235.1| (AL627269) hypothetical protein [Salmonella enterica subsp. enterica serovar Typhi]; hypothetical protein 4541133 1080844 S4646 Shigella flexneri 2a str. 2457T hypothetical protein NP_839758.1 4540366 R 198215 CDS NP_839759.1 30065588 1080845 complement(4541304..4542194) 1 NC_004741.1 residues 13 to 296 of 296 are 59.85 pct identical to residues 8 to 291 of 298 from GenPept : >gb|AAL20040.1| (AE008748) 4-hydroxyphenylacetate catabolism [Salmonella typhimurium LT2]; 4-hydroxyphenylacetate 3-monooxygenase operon regulatory protein 4542194 hpaA 1080845 hpaA Shigella flexneri 2a str. 2457T 4-hydroxyphenylacetate 3-monooxygenase operon regulatory protein NP_839759.1 4541304 R 198215 CDS NP_839760.1 30065589 1079519 complement(4542204..4543559) 1 NC_004741.1 residues 17 to 434 of 451 are 66.58 pct identical to residues 25 to 446 of 455 from GenPept : >emb|CAC90586.1| (AJ414150) 4-hydroxyphenylacetate permease [Yersinia pestis]; 4-hydroxyphenylacetate permease 4543559 hpaX 1079519 hpaX Shigella flexneri 2a str. 2457T 4-hydroxyphenylacetate permease NP_839760.1 4542204 R 198215 CDS NP_839761.1 30065590 1080846 complement(4543581..4544384) 1 NC_004741.1 residues 1 to 251 of 267 are 94.02 pct identical to residues 1 to 251 of 262 from GenPept : >emb|CAA86045.1| (Z37980) hypothetical 2,4-dihydroxy-hepta-2-ene-1,7-dioate aldolase [Escherichia coli]; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase 4544384 hpaI 1080846 hpaI Shigella flexneri 2a str. 2457T 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase NP_839761.1 4543581 R 198215 CDS NP_839762.1 30065591 1080847 complement(4544395..4545198) 1 NC_004741.1 residues 1 to 267 of 267 are 98.87 pct identical to residues 1 to 267 of 267 from GenPept : >emb|CAA86044.1| (Z37980) 2-oxo-hept-3-ene-1,7-dioate hydratase [Escherichia coli]; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase 4545198 hpaH 1080847 hpaH Shigella flexneri 2a str. 2457T 2-oxo-hepta-3-ene-1,7-dioic acid hydratase NP_839762.1 4544395 R 198215 CDS NP_839763.1 30065592 1080848 complement(4545266..4545646) 1 NC_004741.1 residues 1 to 126 of 126 are 88.09 pct identical to residues 1 to 126 of 126 from GenPept : >emb|CAD08230.1| (AL627269) 5-carboxymethyl-2-hydroxymuconate delta-isomerase [Salmonella enterica subsp. enterica serovar Typhi]; 5-carboxymethyl-2-hydroxymuconate delta-isomerase 4545646 hpaF 1080848 hpaF Shigella flexneri 2a str. 2457T 5-carboxymethyl-2-hydroxymuconate delta-isomerase NP_839763.1 4545266 R 198215 CDS NP_839764.1 30065593 1080849 complement(4545656..4546507) 1 NC_004741.1 residues 1 to 283 of 283 are 99.64 pct identical to residues 1 to 283 of 283 from GenPept : >emb|CAA86042.1| (Z37980) homoprotocatechuate dyoxygenase [Escherichia coli]; homoprotocatechuate dyoxygenase 4546507 hpaD 1080849 hpaD Shigella flexneri 2a str. 2457T homoprotocatechuate dyoxygenase NP_839764.1 4545656 R 198215 CDS NP_839765.1 30065594 1080850 complement(4546509..4547975) 1 NC_004741.1 residues 1 to 488 of 488 are 99.18 pct identical to residues 1 to 488 of 488 from GenPept : >emb|CAA86041.1| (Z37980) 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase [Escherichia coli]; 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase 4547975 hpaE 1080850 hpaE Shigella flexneri 2a str. 2457T 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase NP_839765.1 4546509 R 198215 CDS NP_839766.1 30065595 1080852 complement(4547972..4549261) 1 NC_004741.1 residues 1 to 429 of 429 are 95.80 pct identical to residues 1 to 429 of 429 from GenPept : >emb|CAA86040.1| (Z37980) 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxilase/isomer [Escherichia coli]; 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxilase/isomerase 4549261 hpaG 1080852 hpaG Shigella flexneri 2a str. 2457T 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxilase/isomerase NP_839766.1 4547972 R 198215 CDS NP_839767.1 30065596 1080853 4549533..4549979 1 NC_004741.1 residues 1 to 148 of 148 are 100.00 pct identical to residues 1 to 148 of 148 from GenPept : >emb|CAA86039.1| (Z37980) regulator of the meta operon of 3,4dhpa metabolic pathway [Escherichia coli]; regulator of the 4HPA-hydroxylase operon 4549979 hpcR 1080853 hpcR Shigella flexneri 2a str. 2457T regulator of the 4HPA-hydroxylase operon NP_839767.1 4549533 D 198215 CDS NP_839768.1 30065597 1080854 4550098..4551762 1 NC_004741.1 residues 1 to 554 of 554 are 88.08 pct identical to residues 1 to 551 of 551 from Escherichia coli K-12 : B4355; methyl-accepting chemotaxis protein I, serine sensor receptor 4551762 tsr 1080854 tsr Shigella flexneri 2a str. 2457T methyl-accepting chemotaxis protein I, serine sensor receptor NP_839768.1 4550098 D 198215 CDS NP_839769.1 30065598 1080855 complement(4551811..4553172) 1 NC_004741.1 residues 1 to 453 of 453 are 98.89 pct identical to residues 1 to 453 of 453 from Escherichia coli K-12 : B4356; joins former yjiZ and yjjL; transporter 4553172 yjiZ 1080855 yjiZ Shigella flexneri 2a str. 2457T transporter NP_839769.1 4551811 R 198215 CDS NP_839770.1 30065599 1080856 complement(4553387..4554193) 1 NC_004741.1 residues 1 to 268 of 268 are 98.50 pct identical to residues 1 to 268 of 268 from Escherichia coli K-12 : B4357; hypothetical protein 4554193 yjjM 1080856 yjjM Shigella flexneri 2a str. 2457T hypothetical protein NP_839770.1 4553387 R 198215 CDS NP_839771.2 161486365 1080858 complement(4555600..4557891) 1 NC_004741.1 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 4557891 mdoB 1080858 mdoB Shigella flexneri 2a str. 2457T phosphoglycerol transferase I NP_839771.2 4555600 R 198215 CDS NP_839772.1 30065601 1080859 complement(4558145..4558642) 1 NC_004741.1 residues 1 to 165 of 165 are 91.51 pct identical to residues 1 to 165 of 165 from Escherichia coli K-12 : B4360; hypothetical protein 4558642 yjjA 1080859 yjjA Shigella flexneri 2a str. 2457T hypothetical protein NP_839772.1 4558145 R 198215 CDS NP_839773.1 30065602 1080860 complement(4558688..4559425) 1 NC_004741.1 acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 4559425 dnaC 1080860 dnaC Shigella flexneri 2a str. 2457T DNA replication protein DnaC NP_839773.1 4558688 R 198215 CDS NP_839774.1 30065603 1080861 complement(4559428..4559967) 1 NC_004741.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI 4559967 dnaT 1080861 dnaT Shigella flexneri 2a str. 2457T primosomal protein DnaI NP_839774.1 4559428 R 198215 CDS NP_839775.2 229089129 1080862 complement(4560074..4560547) 1 NC_004741.1 residues 1 to 108 of 108 are 99.07 pct identical to residues 1 to 108 of 108 from Escherichia coli K-12 : B4363; hypothetical protein 4560547 yjjB 1080862 yjjB Shigella flexneri 2a str. 2457T hypothetical protein NP_839775.2 4560074 R 198215 CDS NP_839776.1 30065605 1077773 4561932..4562207 1 NC_004741.1 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 4562207 1077773 S4666 Shigella flexneri 2a str. 2457T IS1 orfA NP_839776.1 4561932 D 198215 CDS NP_839777.1 30065606 1080864 4562126..4562629 1 NC_004741.1 residues 1 to 167 of 167 are 90.41 pct identical to residues 1 to 167 of 167 from GenPept : >gb|AAK18365.1|AF348706_54 (AF348706) IS1 transposase [Shigella flexneri]; IS1 orfB 4562629 1080864 S4667 Shigella flexneri 2a str. 2457T IS1 orfB NP_839777.1 4562126 D 198215 CDS NP_839778.2 161486364 1080866 4563227..4563850 1 NC_004741.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 4563850 bglJ 1080866 bglJ Shigella flexneri 2a str. 2457T DNA-binding transcriptional activator BglJ NP_839778.2 4563227 D 198215 CDS NP_839779.1 30065608 1080867 complement(4563888..4564676) 1 NC_004741.1 residues 1 to 262 of 262 are 97.32 pct identical to residues 1 to 262 of 262 from Escherichia coli K-12 : B4367; ferric iron reductase involved in ferric hydroximate transport 4564676 fhuF 1080867 fhuF Shigella flexneri 2a str. 2457T ferric iron reductase involved in ferric hydroximate transport NP_839779.1 4563888 R 198215 CDS NP_839780.1 30065609 1080871 complement(4565691..4566722) 1 NC_004741.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 4566722 rsmC 1080871 rsmC Shigella flexneri 2a str. 2457T 16S ribosomal RNA m2G1207 methyltransferase NP_839780.1 4565691 R 198215 CDS NP_839781.1 30065610 1080873 4566825..4567238 1 NC_004741.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 4567238 holD 1080873 holD Shigella flexneri 2a str. 2457T DNA polymerase III subunit psi NP_839781.1 4566825 D 198215 CDS NP_839782.1 30065611 1080874 4567207..4567653 1 NC_004741.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 4567653 rimI 1080874 rimI Shigella flexneri 2a str. 2457T ribosomal-protein-alanine N-acetyltransferase NP_839782.1 4567207 D 198215 CDS NP_839783.1 30065612 1080875 4567668..4568345 1 NC_004741.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 4568345 yjjG 1080875 yjjG Shigella flexneri 2a str. 2457T nucleotidase NP_839783.1 4567668 D 198215 CDS NP_839784.1 30065613 1080876 4568436..4570025 1 NC_004741.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 4570025 prfC 1080876 prfC Shigella flexneri 2a str. 2457T peptide chain release factor 3 NP_839784.1 4568436 D 198215 CDS NP_839785.1 30065614 1080877 4570418..4571023 1 NC_004741.1 residues 1 to 201 of 201 are 99.50 pct identical to residues 1 to 201 of 201 from Escherichia coli K-12 : B4376; periplasmic protein 4571023 osmY 1080877 osmY Shigella flexneri 2a str. 2457T periplasmic protein NP_839785.1 4570418 D 198215 CDS NP_839786.1 30065615 1080878 4571423..4572496 1 NC_004741.1 residues 1 to 357 of 357 are 99.71 pct identical to residues 1 to 357 of 357 from Escherichia coli K-12 : B4377; hypothetical protein 4572496 yjjU 1080878 yjjU Shigella flexneri 2a str. 2457T hypothetical protein NP_839786.1 4571423 D 198215 CDS NP_839787.1 30065616 1080879 4572637..4573275 1 NC_004741.1 residues 1 to 210 of 212 are 95.71 pct identical to residues 1 to 210 of 211 from Escherichia coli K-12 : B4378; hypothetical protein 4573275 yjjV 1080879 yjjV Shigella flexneri 2a str. 2457T hypothetical protein NP_839787.1 4572637 D 198215 CDS NP_839788.1 30065617 1080880 complement(4573489..4574352) 1 NC_004741.1 residues 1 to 287 of 287 are 99.30 pct identical to residues 1 to 287 of 287 from Escherichia coli K-12 : B4379; activating enzyme 4574352 yjjW 1080880 yjjW Shigella flexneri 2a str. 2457T activating enzyme NP_839788.1 4573489 R 198215 CDS NP_839789.1 30065618 1080881 complement(4574324..4575865) 1 NC_004741.1 residues 1 to 513 of 513 are 99.22 pct identical to residues 1 to 516 of 516 from Escherichia coli K-12 : B4380; hypothetical protein 4575865 yjjI 1080881 yjjI Shigella flexneri 2a str. 2457T hypothetical protein NP_839789.1 4574324 R 198215 CDS NP_839790.1 30065619 1080882 4576123..4576902 1 NC_004741.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 4576902 deoC 1080882 deoC Shigella flexneri 2a str. 2457T deoxyribose-phosphate aldolase NP_839790.1 4576123 D 198215 CDS NP_839791.1 30065620 1080883 4577029..4578351 1 NC_004741.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 4578351 deoA 1080883 deoA Shigella flexneri 2a str. 2457T thymidine phosphorylase NP_839791.1 4577029 D 198215 CDS NP_839792.1 30065621 1080884 4578404..4579627 1 NC_004741.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 4579627 deoB 1080884 deoB Shigella flexneri 2a str. 2457T phosphopentomutase NP_839792.1 4578404 D 198215 CDS NP_839793.1 30065622 1080885 4579684..4580403 1 NC_004741.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 4580403 deoD 1080885 deoD Shigella flexneri 2a str. 2457T purine nucleoside phosphorylase NP_839793.1 4579684 D 198215 CDS NP_839794.1 30065623 1080886 complement(4580564..4580827) 1 NC_004741.1 residues 1 to 87 of 87 are 100.00 pct identical to residues 1 to 87 of 87 from GenPept : >gb|AAG59566.1|AE005669_10 (AE005669) Z5987 gene product [Escherichia coli O157:H7 EDL933]; hypothetical protein 4580827 1080886 S4688 Shigella flexneri 2a str. 2457T hypothetical protein NP_839794.1 4580564 R 198215 CDS NP_839795.1 30065624 1080888 complement(4581902..4582546) 1 NC_004741.1 residues 1 to 200 of 214 are 95.49 pct identical to residues 1 to 200 of 214 from Escherichia coli K-12 : B4387; hypothetical protein 4582546 smp 1080888 smp Shigella flexneri 2a str. 2457T hypothetical protein NP_839795.1 4581902 R 198215 CDS NP_839796.1 30065625 1080889 4582652..4583620 1 NC_004741.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 4583620 serB 1080889 serB Shigella flexneri 2a str. 2457T phosphoserine phosphatase NP_839796.1 4582652 D 198215 CDS NP_839797.1 30065626 1080890 4583669..4585051 1 NC_004741.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4585051 sms 1080890 sms Shigella flexneri 2a str. 2457T DNA repair protein RadA NP_839797.1 4583669 D 198215 CDS NP_839798.2 161486363 1080891 4585072..4586304 1 NC_004741.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 4586304 nadR 1080891 nadR Shigella flexneri 2a str. 2457T nicotinamide-nucleotide adenylyltransferase NP_839798.2 4585072 D 198215 CDS NP_839799.1 30065628 1077709 complement(4586612..4588279) 1 NC_004741.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 4588279 yjjK 1077709 yjjK Shigella flexneri 2a str. 2457T ABC transporter ATP-binding protein NP_839799.1 4586612 R 198215 CDS NP_839800.2 161486362 1080892 4588490..4590427 1 NC_004741.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 4590427 slt 1080892 slt Shigella flexneri 2a str. 2457T lytic murein transglycosylase NP_839800.2 4588490 D 198215 CDS NP_839801.1 30065630 1080894 4590517..4590843 1 NC_004741.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 4590843 trpR 1080894 trpR Shigella flexneri 2a str. 2457T Trp operon repressor NP_839801.1 4590517 D 198215 CDS NP_839802.1 30065631 1078078 4591500..4592147 1 NC_004741.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 4592147 gpmB 1078078 gpmB Shigella flexneri 2a str. 2457T phosphoglycerate mutase NP_839802.1 4591500 D 198215 CDS NP_839803.1 30065632 1080895 complement(4592144..4593013) 1 NC_004741.1 residues 1 to 289 of 289 are 100.00 pct identical to residues 1 to 289 of 289 from Escherichia coli K-12 : B4396; right origin-binding protein 4593013 rob 1080895 rob Shigella flexneri 2a str. 2457T right origin-binding protein NP_839803.1 4592144 R 198215 CDS NP_839804.1 30065633 1080925 4593224..4593697 1 NC_004741.1 residues 1 to 157 of 157 are 100.00 pct identical to residues 1 to 157 of 157 from Escherichia coli K-12 : B4397; hypothetical protein 4593697 creA 1080925 creA Shigella flexneri 2a str. 2457T hypothetical protein NP_839804.1 4593224 D 198215 CDS NP_839805.1 30065634 1080896 4593710..4594399 1 NC_004741.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 4594399 creB 1080896 creB Shigella flexneri 2a str. 2457T DNA-binding response regulator CreB NP_839805.1 4593710 D 198215 CDS NP_839806.1 30065635 1080897 4594399..4595823 1 NC_004741.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 4595823 creC 1080897 creC Shigella flexneri 2a str. 2457T sensory histidine kinase CreC NP_839806.1 4594399 D 198215 CDS NP_839807.1 30065636 1080898 4595881..4597233 1 NC_004741.1 residues 1 to 450 of 450 are 94.88 pct identical to residues 1 to 450 of 450 from Escherichia coli K-12 : B4400; tolerance to colicin E2; hypothetical protein 4597233 creD 1080898 creD Shigella flexneri 2a str. 2457T hypothetical protein NP_839807.1 4595881 D 198215 CDS NP_839808.1 30065637 1080899 complement(4597292..4598008) 1 NC_004741.1 residues 1 to 238 of 238 are 100.00 pct identical to residues 1 to 238 of 238 from Escherichia coli K-12 : B4401; two-component response regulator 4598008 arcA 1080899 arcA Shigella flexneri 2a str. 2457T two-component response regulator NP_839808.1 4597292 R 198215 CDS NP_839809.1 30065638 1080900 4598104..4598244 1 NC_004741.1 residues 1 to 46 of 46 are 100.00 pct identical to residues 1 to 46 of 46 from Escherichia coli K-12 : B4402; hypothetical protein 4598244 yjjY 1080900 yjjY Shigella flexneri 2a str. 2457T hypothetical protein NP_839809.1 4598104 D 198215 CDS NP_839810.1 30065639 1080901 4598644..4599330 1 NC_004741.1 member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 4599330 lasT 1080901 lasT Shigella flexneri 2a str. 2457T RNA methyltransferase NP_839810.1 4598644 D 198215 CDS