-- dump date 20140620_065104 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 300267000001 SEQ_END SEQ_END NC_007606.1 4369232 4369232 DR NC_007606.1; contig end 4369232..4369232 Shigella dysenteriae Sd197 300267000002 SEQ_END SEQ_END NC_007607.1 182726 182726 DR NC_007607.1; contig end 182726..182726 Shigella dysenteriae Sd197 300267000003 SEQ_END SEQ_END NC_009344.1 8953 8953 DR NC_009344.1; contig end 8953..8953 Shigella dysenteriae Sd197 YP_401729.1 CDS thrL NC_007606.1 190 255 D thr operon leader peptide 190..255 Shigella dysenteriae Sd197 3799883 YP_401730.1 CDS thrA NC_007606.1 336 2798 D homoserine dehydrogenase I; multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 336..2798 Shigella dysenteriae Sd197 3796040 YP_401731.1 CDS thrB NC_007606.1 2800 3732 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 2800..3732 Shigella dysenteriae Sd197 3796041 YP_401732.1 CDS thrC NC_007606.1 3733 5019 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 3733..5019 Shigella dysenteriae Sd197 3796042 YP_401733.1 CDS SDY_0005 NC_007606.1 5233 5529 D hypothetical protein 5233..5529 Shigella dysenteriae Sd197 3796043 YP_401734.1 CDS yaaA NC_007606.1 5682 6458 R Code: S; COG: COG3022; hypothetical protein complement(5682..6458) Shigella dysenteriae Sd197 3796044 YP_401736.1 CDS talB NC_007606.1 8230 9183 D Code: G; COG: COG0176; transaldolase B 8230..9183 Shigella dysenteriae Sd197 3796046 YP_401737.1 CDS mogA NC_007606.1 9298 9885 D required for the efficient incorporation of molybdate into molybdoproteins; forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein 9298..9885 Shigella dysenteriae Sd197 3796047 YP_401738.1 CDS yaaH NC_007606.1 9920 10486 R Code: S; COG: COG1584; hypothetical protein complement(9920..10486) Shigella dysenteriae Sd197 3796048 YP_401739.1 CDS SDY_0011 NC_007606.1 10635 11348 R Code: S; COG: COG4735; hypothetical protein complement(10635..11348) Shigella dysenteriae Sd197 3796049 YP_401740.1 CDS yaaI NC_007606.1 11374 11733 R hypothetical protein complement(11374..11733) Shigella dysenteriae Sd197 3796050 YP_401741.1 CDS dnaK NC_007606.1 12155 14071 D DNA biosynthesis; autoregulated heat shock proteins; heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 12155..14071 Shigella dysenteriae Sd197 3796051 YP_401742.1 CDS dnaJ NC_007606.1 14160 15290 D chaperone with DnaK; ''chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion''; molecular chaperone DnaJ 14160..15290 Shigella dysenteriae Sd197 3796052 YP_401743.1 CDS gef NC_007606.1 15394 15603 R interferes with membrane function when in excess; Gef protein complement(15394..15603) Shigella dysenteriae Sd197 3796053 YP_009000618.1 CDS SDY_0017a NC_007606.1 16286 16558 R insertion element iso-IS1N protein InsA complement(16286..16558) Shigella dysenteriae Sd197 18262935 YP_401746.1 CDS nhaA NC_007606.1 16905 18071 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 16905..18071 Shigella dysenteriae Sd197 3796056 YP_401747.1 CDS nhaR NC_007606.1 18131 19036 D Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 18131..19036 Shigella dysenteriae Sd197 3796057 YP_401748.1 CDS SDY_0020 NC_007606.1 19074 19601 R hypothetical protein complement(19074..19601) Shigella dysenteriae Sd197 3796058 YP_009000619.1 CDS SDY_0022a NC_007606.1 19712 19984 D insertion element iso-IS1N protein InsA 19712..19984 Shigella dysenteriae Sd197 18262936 YP_401750.1 CDS SDY_0022 NC_007606.1 20011 20406 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 20011..20406 Shigella dysenteriae Sd197 3797315 YP_401751.1 CDS insB NC_007606.1 20512 20889 R Code: L; COG: COG1662; insertion sequence element IS1 transposase complement(20512..20889) Shigella dysenteriae Sd197 3797316 YP_401752.1 CDS insA NC_007606.1 20934 21209 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(20934..21209) Shigella dysenteriae Sd197 3797317 YP_401753.1 CDS acnB NC_007606.1 21788 24385 D catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 21788..24385 Shigella dysenteriae Sd197 3797318 YP_401754.2 CDS yacL NC_007606.1 24560 24922 D Code: S; COG: COG3112; hypothetical protein 24560..24922 Shigella dysenteriae Sd197 3797319 YP_401755.1 CDS speD NC_007606.1 24960 25754 R S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase complement(24960..25754) Shigella dysenteriae Sd197 3797320 YP_401756.1 CDS speE NC_007606.1 25770 26636 R putrescine aminopropyltransferase; catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase complement(25770..26636) Shigella dysenteriae Sd197 3797321 YP_401758.1 CDS yacK NC_007606.1 27255 28805 D laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 27255..28805 Shigella dysenteriae Sd197 3797323 YP_401759.1 CDS insA NC_007606.1 29799 30074 D Code: L; COG: COG3677; insertion element IS1 protein InsA 29799..30074 Shigella dysenteriae Sd197 3797324 YP_401760.1 CDS insB NC_007606.1 30119 30496 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 30119..30496 Shigella dysenteriae Sd197 3797325 YP_401761.2 CDS hpt NC_007606.1 32224 32760 D Code: F; COG: COG0634; hypoxanthine phosphoribosyltransferase 32224..32760 Shigella dysenteriae Sd197 3797327 YP_401762.1 CDS yadF NC_007606.1 32801 33463 R catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase complement(32801..33463) Shigella dysenteriae Sd197 3797328 YP_401763.1 CDS yadG NC_007606.1 33572 34498 D Code: V; COG: COG1131; ATPase 33572..34498 Shigella dysenteriae Sd197 3797329 YP_401764.1 CDS yadH NC_007606.1 34495 35265 D Code: V; COG: COG0842; hypothetical protein 34495..35265 Shigella dysenteriae Sd197 3797330 YP_401765.1 CDS yadI NC_007606.1 35370 35810 D Code: G; COG: COG2893; PTS system transporter subunit IIB 35370..35810 Shigella dysenteriae Sd197 3797331 YP_401768.1 CDS panD NC_007606.1 37108 37488 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(37108..37488) Shigella dysenteriae Sd197 3799806 YP_401769.1 CDS yadD NC_007606.1 37762 38562 D Code: S; COG: COG5464; hypothetical protein 37762..38562 Shigella dysenteriae Sd197 3799807 YP_401770.1 CDS insA NC_007606.1 38591 38866 D Code: L; COG: COG3677; insertion element IS1 protein InsA 38591..38866 Shigella dysenteriae Sd197 3799808 YP_401771.1 CDS insB NC_007606.1 38911 39288 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 38911..39288 Shigella dysenteriae Sd197 3799809 YP_401772.1 CDS rpsT NC_007606.1 39604 39867 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(39604..39867) Shigella dysenteriae Sd197 3799810 YP_401773.1 CDS SDY_0046 NC_007606.1 39970 40188 D hypothetical protein 39970..40188 Shigella dysenteriae Sd197 3799811 YP_401774.1 CDS ribF NC_007606.1 40196 41137 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 40196..41137 Shigella dysenteriae Sd197 3799812 YP_401775.1 CDS ileS NC_007606.1 41180 43996 D ''IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme''; isoleucyl-tRNA synthetase 41180..43996 Shigella dysenteriae Sd197 3799813 YP_401776.1 CDS lspA NC_007606.1 43996 44490 D SPase II; lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 43996..44490 Shigella dysenteriae Sd197 3799814 YP_401777.1 CDS slpA NC_007606.1 44578 45027 D rotamase; Code: O; COG: COG1047; FKBP-type peptidylprolyl isomerase 44578..45027 Shigella dysenteriae Sd197 3799815 YP_401778.1 CDS ispH NC_007606.1 45029 45979 D involved in penicillin tolerance; catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 45029..45979 Shigella dysenteriae Sd197 3799816 YP_401779.1 CDS yaaF NC_007606.1 46045 46959 D catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 46045..46959 Shigella dysenteriae Sd197 3799817 YP_401780.1 CDS dapB NC_007606.1 47126 47947 D ''catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis''; dihydrodipicolinate reductase 47126..47947 Shigella dysenteriae Sd197 3799818 YP_401781.1 CDS carA NC_007606.1 48405 49553 D small subunit; catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 48405..49553 Shigella dysenteriae Sd197 3799819 YP_401782.1 CDS carB NC_007606.1 49571 52792 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 49571..52792 Shigella dysenteriae Sd197 3799820 YP_401784.1 CDS caiE NC_007606.1 53534 54145 R involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE complement(53534..54145) Shigella dysenteriae Sd197 3799822 YP_401785.1 CDS caiD NC_007606.1 54130 55023 R catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase complement(54130..55023) Shigella dysenteriae Sd197 3799823 YP_401786.1 CDS caiC NC_007606.1 55024 56592 R Code: IQ; COG: COG0318; crotonobetaine/carnitine-CoA ligase complement(55024..56592) Shigella dysenteriae Sd197 3799824 YP_401787.1 CDS caiB NC_007606.1 56651 57868 R ''catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine''; crotonobetainyl-CoA:carnitine CoA-transferase complement(56651..57868) Shigella dysenteriae Sd197 3798940 YP_401788.1 CDS caiA NC_007606.1 57997 59139 R catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase complement(57997..59139) Shigella dysenteriae Sd197 3798941 YP_401789.1 CDS caiT NC_007606.1 59170 60684 R catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter complement(59170..60684) Shigella dysenteriae Sd197 3798942 YP_401790.2 CDS fixA NC_007606.1 61156 61926 D probable flavoprotein subunit; carnitine metabolism; ''required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase''; electron transfer flavoprotein FixA 61156..61926 Shigella dysenteriae Sd197 3798943 YP_401791.1 CDS fixB NC_007606.1 61941 62882 D probable flavoprotein subunit; carnitine metabolism; involved in electron transfer during carnitine metabolism; electron transfer flavoprotein FixB 61941..62882 Shigella dysenteriae Sd197 3798944 YP_401793.1 CDS fixX NC_007606.1 64215 64502 D Code: C; COG: COG2440; ferredoxin 64215..64502 Shigella dysenteriae Sd197 3798946 YP_401796.1 CDS yabF NC_007606.1 66002 66532 D ''Required for full activity of KefC, a potassium-proton antiporter''; glutathione-regulated potassium-efflux system ancillary protein KefF 66002..66532 Shigella dysenteriae Sd197 3798949 YP_401797.1 CDS kefC NC_007606.1 66525 68192 D Code: P; COG: COG1226; K+ efflux antiporter, glutathione-regulated 66525..68192 Shigella dysenteriae Sd197 3798950 YP_401798.1 CDS folA NC_007606.1 68384 68863 D trimethoprim resistance; catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 68384..68863 Shigella dysenteriae Sd197 3798951 YP_401799.1 CDS SDY_0072 NC_007606.1 68949 69182 D Code: R; COG: COG5302; antitoxin of gyrase inhibiting toxin-antitoxin system 68949..69182 Shigella dysenteriae Sd197 3798952 YP_401800.1 CDS SDY_0073 NC_007606.1 69185 69499 D toxin of gyrase inhibiting toxin-antitoxin system 69185..69499 Shigella dysenteriae Sd197 3798953 YP_401801.1 CDS apaH NC_007606.1 69496 70344 R ''hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP''; diadenosine tetraphosphatase complement(69496..70344) Shigella dysenteriae Sd197 3798954 YP_401802.1 CDS apaG NC_007606.1 70351 70728 R protein associated with Co2+ and Mg2+ efflux; ApaG protein complement(70351..70728) Shigella dysenteriae Sd197 3798955 YP_401803.1 CDS ksgA NC_007606.1 70731 71552 R rRNA dimethyltransferase; catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(70731..71552) Shigella dysenteriae Sd197 3798956 YP_401804.1 CDS pdxA NC_007606.1 71549 72538 R catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase complement(71549..72538) Shigella dysenteriae Sd197 3798957 YP_401805.1 CDS surA NC_007606.1 72538 73824 R ''Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB''; peptidyl-prolyl cis-trans isomerase SurA complement(72538..73824) Shigella dysenteriae Sd197 3798958 YP_401806.1 CDS imp NC_007606.1 73877 76231 R determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein complement(73877..76231) Shigella dysenteriae Sd197 3798959 YP_401807.1 CDS djlA NC_007606.1 76486 77301 D functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 76486..77301 Shigella dysenteriae Sd197 3799440 YP_401808.1 CDS yabP NC_007606.1 77596 78312 D hypothetical protein 77596..78312 Shigella dysenteriae Sd197 3799441 YP_401809.1 CDS yabO NC_007606.1 78719 79378 R catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A complement(78719..79378) Shigella dysenteriae Sd197 3799442 YP_401810.1 CDS hepA NC_007606.1 79390 82296 R ''transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA''; ATP-dependent helicase HepA complement(79390..82296) Shigella dysenteriae Sd197 3799443 YP_401811.1 CDS SDY_0084 NC_007606.1 83937 84332 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(83937..84332) Shigella dysenteriae Sd197 3799444 YP_009000620.1 CDS SDY_0084a NC_007606.1 84359 84631 R insertion element iso-IS1N protein InsA complement(84359..84631) Shigella dysenteriae Sd197 18262937 YP_401812.1 CDS insA NC_007606.1 85070 85345 D Code: L; COG: COG3677; insertion element IS1 protein InsA 85070..85345 Shigella dysenteriae Sd197 3799445 YP_401813.1 CDS insB NC_007606.1 85390 85767 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 85390..85767 Shigella dysenteriae Sd197 3799446 YP_401814.1 CDS araD NC_007606.1 86437 87132 R catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase complement(86437..87132) Shigella dysenteriae Sd197 3799448 YP_401815.1 CDS araA NC_007606.1 87300 88802 R catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase complement(87300..88802) Shigella dysenteriae Sd197 3799449 YP_401816.1 CDS araB NC_007606.1 88813 90513 R catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase complement(88813..90513) Shigella dysenteriae Sd197 3799450 YP_401817.1 CDS yabI NC_007606.1 91820 92584 D Code: S; COG: COG0586; hypothetical protein 91820..92584 Shigella dysenteriae Sd197 3799452 YP_401818.1 CDS thiQ NC_007606.1 92698 93396 R with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine ABC transporter ATP-binding protein complement(92698..93396) Shigella dysenteriae Sd197 3799453 YP_401819.1 CDS thiP NC_007606.1 93380 94990 R permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine ABC transporter permease complement(93380..94990) Shigella dysenteriae Sd197 3799454 YP_401820.1 CDS tbpA NC_007606.1 94966 95949 R part of the thiamine and TPP transport system tbpA-thiPQ; thiamine ABC transporter substrate-binding protein complement(94966..95949) Shigella dysenteriae Sd197 3799455 YP_401821.1 CDS insA NC_007606.1 96649 96924 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(96649..96924) Shigella dysenteriae Sd197 3799456 YP_401822.1 CDS yabN NC_007606.1 97447 99105 R activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR complement(97447..99105) Shigella dysenteriae Sd197 3799457 YP_401823.1 CDS leuD NC_007606.1 99433 100038 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(99433..100038) Shigella dysenteriae Sd197 3799458 YP_401824.1 CDS leuC NC_007606.1 100049 101449 R dehydratase subunit; ''dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate''; isopropylmalate isomerase large subunit complement(100049..101449) Shigella dysenteriae Sd197 3795905 YP_401825.2 CDS leuB NC_007606.1 101452 102543 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(101452..102543) Shigella dysenteriae Sd197 3795906 YP_401826.1 CDS leuA NC_007606.1 102543 104114 R catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase complement(102543..104114) Shigella dysenteriae Sd197 3795907 YP_401827.1 CDS leuL NC_007606.1 104207 104290 R involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide complement(104207..104290) Shigella dysenteriae Sd197 3795908 YP_009000621.1 CDS SDY_0102a NC_007606.1 104462 104734 D insertion element iso-IS1N protein InsA 104462..104734 Shigella dysenteriae Sd197 18262938 YP_009000622.1 CDS insB NC_007606.1 105404 105781 R insertion sequence element IS1 transposase complement(105404..105781) Shigella dysenteriae Sd197 3795911 YP_401830.1 CDS insA NC_007606.1 105826 106101 R Code: L; COG: COG3677; insertion element iso-IS1d protein InsA complement(105826..106101) Shigella dysenteriae Sd197 3795912 YP_401831.1 CDS ilvI NC_007606.1 106283 108007 D ''catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive''; acetolactate synthase 3 catalytic subunit 106283..108007 Shigella dysenteriae Sd197 3795913 YP_401832.1 CDS ilvH NC_007606.1 108010 108501 D valine sensitive; ''with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit''; acetolactate synthase 3 regulatory subunit 108010..108501 Shigella dysenteriae Sd197 3795914 YP_401834.1 CDS fruR NC_007606.1 108681 109685 D binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 108681..109685 Shigella dysenteriae Sd197 3795916 YP_401835.1 CDS yabB NC_007606.1 110288 110746 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 110288..110746 Shigella dysenteriae Sd197 3795917 YP_401836.1 CDS mraW NC_007606.1 110748 111689 D Code: M; COG: COG0275; S-adenosyl-methyltransferase MraW 110748..111689 Shigella dysenteriae Sd197 3795918 YP_401837.1 CDS ftsL NC_007606.1 111686 112051 D ingrowth of wall at septum; membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 111686..112051 Shigella dysenteriae Sd197 3795919 YP_401838.1 CDS ftsI NC_007606.1 112067 113833 D septum formation; peptidoglycan synthetase; Code: M; COG: COG0768; penicillin-binding protein 3 112067..113833 Shigella dysenteriae Sd197 3795920 YP_401839.1 CDS murE NC_007606.1 113820 115307 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 113820..115307 Shigella dysenteriae Sd197 3795921 YP_401840.1 CDS murF NC_007606.1 115304 116662 D Code: M; COG: COG0770; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 115304..116662 Shigella dysenteriae Sd197 3795922 YP_401841.1 CDS mraY NC_007606.1 116656 117738 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 116656..117738 Shigella dysenteriae Sd197 3795923 YP_401842.1 CDS murD NC_007606.1 117741 119057 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 117741..119057 Shigella dysenteriae Sd197 3795924 YP_401843.1 CDS ftsW NC_007606.1 119057 120301 D cell division; membrane protein involved in shape determination; integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 119057..120301 Shigella dysenteriae Sd197 3799344 YP_401844.1 CDS murG NC_007606.1 120298 121365 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 120298..121365 Shigella dysenteriae Sd197 3799345 YP_401845.1 CDS murC NC_007606.1 121419 122894 D L-alanine adding enzyme; Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 121419..122894 Shigella dysenteriae Sd197 3799346 YP_401846.1 CDS ddl NC_007606.1 122887 123807 D affects cell division; D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 122887..123807 Shigella dysenteriae Sd197 3799347 YP_401847.1 CDS ftsQ NC_007606.1 123809 124639 D ingrowth of wall at septum; involved in septum formation; cell division protein FtsQ 123809..124639 Shigella dysenteriae Sd197 3799348 YP_401848.1 CDS ftsA NC_007606.1 124636 125898 D septation process, complexes with FtsZ; associated with junctions of inner and outer membranes; ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 124636..125898 Shigella dysenteriae Sd197 3799349 YP_401849.1 CDS ftsZ NC_007606.1 125959 127110 D cell division; forms circumferential ring; ''GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function''; cell division protein FtsZ 125959..127110 Shigella dysenteriae Sd197 3799350 YP_401850.1 CDS lpxC NC_007606.1 127211 128128 D lipid A biosynthesis; zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 127211..128128 Shigella dysenteriae Sd197 3799351 YP_401851.2 CDS yacA NC_007606.1 128358 128870 D secM translational pause allows for the initiation of secA translation; SecA regulator SecM 128358..128870 Shigella dysenteriae Sd197 3799352 YP_401852.1 CDS secA NC_007606.1 128932 131637 D secretion protein; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 128932..131637 Shigella dysenteriae Sd197 3799353 YP_401853.1 CDS mutT NC_007606.1 131697 132095 D prefers dGTP; causes AT-GC transversions; Code: LR; COG: COG0494; nucleoside triphosphate pyrophosphohydrolase 131697..132095 Shigella dysenteriae Sd197 3799354 YP_401854.1 CDS SDY_0130 NC_007606.1 132100 132234 R hypothetical protein complement(132100..132234) Shigella dysenteriae Sd197 3799355 YP_401855.1 CDS yacG NC_007606.1 132185 132382 R Code: S; COG: COG3024; zinc-binding protein complement(132185..132382) Shigella dysenteriae Sd197 3799356 YP_401856.1 CDS yacF NC_007606.1 132392 133135 R Code: S; COG: COG4582; hypothetical protein complement(132392..133135) Shigella dysenteriae Sd197 3799357 YP_401857.1 CDS coaE NC_007606.1 133135 133755 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(133135..133755) Shigella dysenteriae Sd197 3799358 YP_401858.1 CDS guaC NC_007606.1 133980 135023 D catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 133980..135023 Shigella dysenteriae Sd197 3799359 YP_401861.1 CDS ppdD NC_007606.1 137641 138081 R Code: NU; COG: COG4969; major pilin subunit complement(137641..138081) Shigella dysenteriae Sd197 3799054 YP_401862.1 CDS nadC NC_007606.1 138284 139177 R ''catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide''; quinolinate phosphoribosyltransferase complement(138284..139177) Shigella dysenteriae Sd197 3799055 YP_401863.1 CDS ampD NC_007606.1 139265 139816 D Code: V; COG: COG3023; N-acetyl-anhydromuranmyl-L-alanine amidase 139265..139816 Shigella dysenteriae Sd197 3799056 YP_401864.1 CDS ampE NC_007606.1 139813 140667 D involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 139813..140667 Shigella dysenteriae Sd197 3799057 YP_401865.1 CDS aroP NC_007606.1 140710 142083 R Code: E; COG: COG1113; aromatic amino acid transporter complement(140710..142083) Shigella dysenteriae Sd197 3799058 YP_401866.1 CDS pdhR NC_007606.1 142624 143388 D activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 142624..143388 Shigella dysenteriae Sd197 3799059 YP_401867.1 CDS aceE NC_007606.1 143549 146212 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 143549..146212 Shigella dysenteriae Sd197 3799060 YP_401868.1 CDS aceF NC_007606.1 146227 148107 D E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 146227..148107 Shigella dysenteriae Sd197 3799061 YP_401869.1 CDS lpdA NC_007606.1 148315 149739 D component of 2-oxodehydrogenase and pyruvate complexes; L-protein of glycine cleavage complex; E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 148315..149739 Shigella dysenteriae Sd197 3799062 YP_401872.1 CDS insB NC_007606.1 151404 151781 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(151404..151781) Shigella dysenteriae Sd197 3799065 YP_401873.1 CDS insA NC_007606.1 151826 152101 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(151826..152101) Shigella dysenteriae Sd197 3799066 YP_401874.1 CDS SDY_0151 NC_007606.1 152152 152643 R hypothetical protein complement(152152..152643) Shigella dysenteriae Sd197 3799067 YP_401875.1 CDS SDY_0152 NC_007606.1 152621 153016 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(152621..153016) Shigella dysenteriae Sd197 3799068 YP_009000623.1 CDS SDY0152a NC_007606.1 153043 153315 R insertion element iso-IS1N protein InsA complement(153043..153315) Shigella dysenteriae Sd197 18262939 YP_401877.1 CDS panB NC_007606.1 153922 154716 D ''catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate''; 3-methyl-2-oxobutanoate hydroxymethyltransferase 153922..154716 Shigella dysenteriae Sd197 3799070 YP_401878.1 CDS panC NC_007606.1 154728 155579 D catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 154728..155579 Shigella dysenteriae Sd197 3799071 YP_401879.1 CDS insB NC_007606.1 156192 156569 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 156192..156569 Shigella dysenteriae Sd197 3799072 YP_009000624.1 CDS SDY0156a NC_007606.1 156818 157090 D insertion element iso-IS1N protein InsA 156818..157090 Shigella dysenteriae Sd197 18262940 YP_401880.1 CDS SDY_0157 NC_007606.1 157117 157512 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 157117..157512 Shigella dysenteriae Sd197 3799073 YP_401881.1 CDS folK NC_007606.1 157582 158061 R ''catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP''; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase complement(157582..158061) Shigella dysenteriae Sd197 3795789 YP_401882.2 CDS pcnB NC_007606.1 158058 159476 R Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase complement(158058..159476) Shigella dysenteriae Sd197 3795790 YP_401883.2 CDS yadB NC_007606.1 159515 160411 R ''this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu''; glutamyl-Q tRNA(Asp) synthetase complement(159515..160411) Shigella dysenteriae Sd197 3795791 YP_401884.1 CDS dksA NC_007606.1 160478 160933 R Code: T; COG: COG1734; DnaK transcriptional regulator DksA complement(160478..160933) Shigella dysenteriae Sd197 3795792 YP_401885.1 CDS sfsA NC_007606.1 161111 161815 R Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A complement(161111..161815) Shigella dysenteriae Sd197 3795793 YP_401886.1 CDS yadP NC_007606.1 161830 162369 R Code: J; COG: COG1514; hypothetical protein complement(161830..162369) Shigella dysenteriae Sd197 3795794 YP_401887.1 CDS mrcB NC_007606.1 165059 167593 D penicillin-binding protein 1B; ''bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell''; penicillin-binding protein 1b 165059..167593 Shigella dysenteriae Sd197 3795796 YP_401888.1 CDS fhuA NC_007606.1 167813 170056 D involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 167813..170056 Shigella dysenteriae Sd197 3795797 YP_401889.1 CDS fhuC NC_007606.1 170107 170904 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate ABC transporter ATP-binding protein 170107..170904 Shigella dysenteriae Sd197 3795798 YP_401890.1 CDS fhuD NC_007606.1 170904 171794 D Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate ABC transporter substrate-binding protein 170904..171794 Shigella dysenteriae Sd197 3795799 YP_401891.1 CDS fhuB NC_007606.1 171791 173773 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate ABC transporter permease 171791..173773 Shigella dysenteriae Sd197 3795800 YP_401892.1 CDS hemL NC_007606.1 173808 175088 R aminomutase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(173808..175088) Shigella dysenteriae Sd197 3795801 YP_401893.1 CDS yadQ NC_007606.1 175313 176734 D Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 175313..176734 Shigella dysenteriae Sd197 3795802 YP_401894.1 CDS yadR NC_007606.1 176816 177160 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 176816..177160 Shigella dysenteriae Sd197 3795803 YP_401895.1 CDS yadS NC_007606.1 177207 177830 R Code: S; COG: COG2860; hypothetical protein complement(177207..177830) Shigella dysenteriae Sd197 3795804 YP_401896.1 CDS yadT NC_007606.1 177868 178668 R solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF complement(177868..178668) Shigella dysenteriae Sd197 3795805 YP_401897.1 CDS pfs NC_007606.1 178661 179359 R enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(178661..179359) Shigella dysenteriae Sd197 3795806 YP_009000625.1 CDS SDY_0177a NC_007606.1 180498 180770 D insertion element iso-IS1N protein InsA 180498..180770 Shigella dysenteriae Sd197 18262941 YP_401898.1 CDS SDY_0177 NC_007606.1 180797 181192 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 180797..181192 Shigella dysenteriae Sd197 3798524 YP_401899.1 CDS htrA NC_007606.1 181864 183288 D heat shock protein HtrA; protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 181864..183288 Shigella dysenteriae Sd197 3798525 YP_401902.1 CDS yaeH NC_007606.1 184685 185071 R hypothetical protein complement(184685..185071) Shigella dysenteriae Sd197 3798528 YP_401903.1 CDS dapD NC_007606.1 185385 186209 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(185385..186209) Shigella dysenteriae Sd197 3798529 YP_401904.1 CDS glnD NC_007606.1 186240 188912 R uridylyltransferase acts on regulator of glnA; catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase complement(186240..188912) Shigella dysenteriae Sd197 3798530 YP_401905.1 CDS map NC_007606.1 188974 189768 R ''catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn''; methionine aminopeptidase complement(188974..189768) Shigella dysenteriae Sd197 3798531 YP_401906.1 CDS rpsB NC_007606.1 190136 190861 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 190136..190861 Shigella dysenteriae Sd197 3798532 YP_401907.1 CDS tsf NC_007606.1 191119 191970 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 191119..191970 Shigella dysenteriae Sd197 3798533 YP_401908.1 CDS pyrH NC_007606.1 192117 192842 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 192117..192842 Shigella dysenteriae Sd197 3798534 YP_401909.1 CDS frr NC_007606.1 193134 193691 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 193134..193691 Shigella dysenteriae Sd197 3798535 YP_401910.1 CDS yaeM NC_007606.1 193783 194979 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 193783..194979 Shigella dysenteriae Sd197 3798536 YP_401911.1 CDS yaeS NC_007606.1 195165 195926 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 195165..195926 Shigella dysenteriae Sd197 3798537 YP_401912.2 CDS cdsA NC_007606.1 195939 196796 D catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 195939..196796 Shigella dysenteriae Sd197 3798538 YP_401913.1 CDS yaeL NC_007606.1 196808 198160 D catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 196808..198160 Shigella dysenteriae Sd197 3798539 YP_401914.1 CDS yaeT NC_007606.1 198190 200622 D ''part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins''; outer membrane protein assembly factor YaeT 198190..200622 Shigella dysenteriae Sd197 3798540 YP_401915.1 CDS hlpA NC_007606.1 200744 201229 D located in outer membrane or nucleoid; Code: M; COG: COG2825; periplasmic chaperone 200744..201229 Shigella dysenteriae Sd197 3798541 YP_401916.1 CDS lpxD NC_007606.1 201233 202258 D third step of endotoxin (lipidA) synthesis; adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 201233..202258 Shigella dysenteriae Sd197 3798542 YP_401917.1 CDS fabZ NC_007606.1 202363 202818 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 202363..202818 Shigella dysenteriae Sd197 3798543 YP_401918.1 CDS lpxA NC_007606.1 202822 203610 D lipid A biosynthesis; catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 202822..203610 Shigella dysenteriae Sd197 3795730 YP_401919.1 CDS lpxB NC_007606.1 203610 204758 D lipid A biosynthesis, penultimate step; ''catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM''; lipid-A-disaccharide synthase 203610..204758 Shigella dysenteriae Sd197 3795731 YP_401920.1 CDS rnhB NC_007606.1 204755 205351 D degrades RNA of DNA-RNA hybrids; RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 204755..205351 Shigella dysenteriae Sd197 3795732 YP_401921.1 CDS dnaE NC_007606.1 205388 208870 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 205388..208870 Shigella dysenteriae Sd197 3795733 YP_401922.1 CDS accA NC_007606.1 208883 209842 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 208883..209842 Shigella dysenteriae Sd197 3795734 YP_401923.1 CDS insA NC_007606.1 210154 210429 D Code: L; COG: COG3677; insertion element IS1 protein InsA 210154..210429 Shigella dysenteriae Sd197 3795735 YP_401924.1 CDS insB NC_007606.1 210474 210851 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 210474..210851 Shigella dysenteriae Sd197 3795736 YP_401925.1 CDS yaeR NC_007606.1 212959 213291 D Code: E; COG: COG0346; hypothetical protein 212959..213291 Shigella dysenteriae Sd197 3795738 YP_401926.1 CDS tilS NC_007606.1 213359 214654 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 213359..214654 Shigella dysenteriae Sd197 3795739 YP_401927.1 CDS yaeO NC_007606.1 214707 214967 R Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator complement(214707..214967) Shigella dysenteriae Sd197 3795740 YP_401928.1 CDS yaeP NC_007606.1 214954 215172 R hypothetical protein complement(214954..215172) Shigella dysenteriae Sd197 3795741 YP_401929.1 CDS yaeQ NC_007606.1 215320 215865 D Code: S; COG: COG4681; hypothetical protein 215320..215865 Shigella dysenteriae Sd197 3795742 YP_401930.1 CDS yaeJ NC_007606.1 215862 216284 D Code: J; COG: COG1186; peptidyl-tRNA hydrolase domain-containing protein 215862..216284 Shigella dysenteriae Sd197 3795743 YP_401931.1 CDS cutF NC_007606.1 216298 217008 D lipoprotein; Code: MP; COG: COG3015; copper homeostasis and adhesion lipoprotein 216298..217008 Shigella dysenteriae Sd197 3795744 YP_401932.1 CDS yaeF NC_007606.1 217152 217976 R hypothetical protein complement(217152..217976) Shigella dysenteriae Sd197 3795745 YP_401933.1 CDS proS NC_007606.1 218029 219747 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(218029..219747) Shigella dysenteriae Sd197 3795746 YP_401934.1 CDS yaeB NC_007606.1 219858 220565 R Code: S; COG: COG1720; hypothetical protein complement(219858..220565) Shigella dysenteriae Sd197 3795747 YP_401935.1 CDS rcsF NC_007606.1 220562 220966 R interacts with RcsB; outer membrane lipoprotein complement(220562..220966) Shigella dysenteriae Sd197 3795748 YP_401936.1 CDS metQ NC_007606.1 221084 221899 R Code: P; COG: COG1464; DL-methionine ABC transporter substrate-binding protein complement(221084..221899) Shigella dysenteriae Sd197 3797846 YP_401937.1 CDS yaeE NC_007606.1 221939 222592 R part of the MetNIQ methionine uptake system; DL-methionine ABC transporter permease complement(221939..222592) Shigella dysenteriae Sd197 3797847 YP_401938.1 CDS metN NC_007606.1 222585 223616 R part of the metNIQ transport system for methionine; DL-methionine ABC transporter ATP-binding protein complement(222585..223616) Shigella dysenteriae Sd197 3797848 YP_401939.1 CDS yaeD NC_007606.1 223804 224376 D ''Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate''; D,D-heptose 1,7-bisphosphate phosphatase 223804..224376 Shigella dysenteriae Sd197 3797849 YP_401940.1 CDS dkgB NC_007606.1 230128 230895 D ''catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid''; 2,5-diketo-D-gluconate reductase B 230128..230895 Shigella dysenteriae Sd197 3797856 YP_401941.1 CDS yafC NC_007606.1 230927 231841 R Code: K; COG: COG0583; LysR family transcriptional regulator complement(230927..231841) Shigella dysenteriae Sd197 3797857 YP_401942.1 CDS yafD NC_007606.1 232082 232882 D Code: S; COG: COG3021; hypothetical protein 232082..232882 Shigella dysenteriae Sd197 3797858 YP_401944.1 CDS mltD NC_007606.1 233762 235120 R cytochrome c552; ''catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall''; membrane-bound lytic murein transglycosylase D complement(233762..235120) Shigella dysenteriae Sd197 3796958 YP_401945.1 CDS gloB NC_007606.1 235192 235947 R catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase complement(235192..235947) Shigella dysenteriae Sd197 3796959 YP_401946.1 CDS yafS NC_007606.1 235963 236703 D Code: QR; COG: COG0500; hypothetical protein 235963..236703 Shigella dysenteriae Sd197 3796960 YP_401947.1 CDS rnhA NC_007606.1 236700 237167 R degrades RNA of DNA-RNA hybrids, participates in DNA replication; An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H complement(236700..237167) Shigella dysenteriae Sd197 3796961 YP_401948.1 CDS dnaQ NC_007606.1 237232 237963 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 237232..237963 Shigella dysenteriae Sd197 3796962 YP_401949.1 CDS insB NC_007606.1 238404 238781 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(238404..238781) Shigella dysenteriae Sd197 3796964 YP_401950.1 CDS insA NC_007606.1 238826 239101 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(238826..239101) Shigella dysenteriae Sd197 3796965 YP_401951.1 CDS SDY_0238 NC_007606.1 239152 239412 R hypothetical protein complement(239152..239412) Shigella dysenteriae Sd197 3796966 YP_009000626.1 CDS SDY_0241a NC_007606.1 239971 240243 R insertion element iso-IS1N protein InsA complement(239971..240243) Shigella dysenteriae Sd197 18262942 YP_009000627.1 CDS SDY0242a NC_007606.1 241442 241714 D insertion element iso-IS1N protein InsA 241442..241714 Shigella dysenteriae Sd197 18262943 YP_401955.2 CDS SDY_0242 NC_007606.1 241741 242136 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 241741..242136 Shigella dysenteriae Sd197 3796970 YP_401958.1 CDS yafV NC_007606.1 243525 244295 R Code: R; COG: COG0388; hypothetical protein complement(243525..244295) Shigella dysenteriae Sd197 3796973 YP_401959.1 CDS ykfE NC_007606.1 244449 244922 D inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 244449..244922 Shigella dysenteriae Sd197 3796974 YP_401960.1 CDS gmhA NC_007606.1 247649 248227 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 247649..248227 Shigella dysenteriae Sd197 3799596 YP_401961.1 CDS yafJ NC_007606.1 248433 249200 D Code: R; COG: COG0121; amidotransferase 248433..249200 Shigella dysenteriae Sd197 3799597 YP_401962.1 CDS yafK NC_007606.1 249171 249911 R Code: S; COG: COG3034; hypothetical protein complement(249171..249911) Shigella dysenteriae Sd197 3799598 YP_401963.1 CDS yafQ NC_007606.1 250067 250345 R Code: S; COG: COG3041; hypothetical protein complement(250067..250345) Shigella dysenteriae Sd197 3799599 YP_401964.1 CDS dinJ NC_007606.1 250348 250608 R Code: L; COG: COG3077; damage-inducible protein J complement(250348..250608) Shigella dysenteriae Sd197 3799600 YP_401965.1 CDS yafL NC_007606.1 250818 251567 D Code: M; COG: COG0791; lipoprotein 250818..251567 Shigella dysenteriae Sd197 3799601 YP_401966.1 CDS yafM NC_007606.1 251743 252081 D Code: L; COG: COG1943; hypothetical protein 251743..252081 Shigella dysenteriae Sd197 3799602 YP_009000628.1 CDS SDY_0254a NC_007606.1 252117 252389 D insertion element iso-IS1N protein InsA 252117..252389 Shigella dysenteriae Sd197 18262944 YP_401967.1 CDS SDY_0255 NC_007606.1 252416 252811 D Code: L; COG: COG1662; insertion element IS1 protein InsB 252416..252811 Shigella dysenteriae Sd197 3799603 YP_401968.1 CDS sfmC NC_007606.1 253042 253407 D Code: NU; COG: COG3121; chaperone 253042..253407 Shigella dysenteriae Sd197 3799604 YP_401969.1 CDS insA NC_007606.1 253441 253716 D Code: L; COG: COG3677; insertion element IS1 protein InsA 253441..253716 Shigella dysenteriae Sd197 3799605 YP_401970.1 CDS insB NC_007606.1 253761 254138 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 253761..254138 Shigella dysenteriae Sd197 3799606 YP_401971.1 CDS SDY_0260 NC_007606.1 254653 255048 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(254653..255048) Shigella dysenteriae Sd197 3799608 YP_009000629.1 CDS SDY_0260a NC_007606.1 255075 255347 R insertion element iso-IS1N protein InsA complement(255075..255347) Shigella dysenteriae Sd197 18262945 YP_009000630.1 CDS SDY_0263a NC_007606.1 255702 255974 D insertion element iso-IS1N protein InsA 255702..255974 Shigella dysenteriae Sd197 18262946 YP_401972.1 CDS SDY_0261 NC_007606.1 256001 256396 D Code: L; COG: COG1662; insertion element IS1 protein InsB 256001..256396 Shigella dysenteriae Sd197 3799609 YP_009000631.1 CDS insB NC_007606.1 263221 263598 D insertion element iso-IS1d protein InsB 263221..263598 Shigella dysenteriae Sd197 3799844 YP_401977.1 CDS fdrA NC_007606.1 263934 265604 D involved in protein transport; multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 263934..265604 Shigella dysenteriae Sd197 3799845 YP_401978.2 CDS ylbE NC_007606.1 265614 266873 D hypothetical protein 265614..266873 Shigella dysenteriae Sd197 3799846 YP_401979.1 CDS ylbF NC_007606.1 266884 267699 D carboxylase 266884..267699 Shigella dysenteriae Sd197 3799847 YP_401980.1 CDS insB NC_007606.1 267968 268345 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(267968..268345) Shigella dysenteriae Sd197 3799849 YP_401981.1 CDS insA NC_007606.1 268390 268665 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(268390..268665) Shigella dysenteriae Sd197 3799850 YP_401982.1 CDS purK NC_007606.1 269505 270572 R phosphoribosylaminoimidazole carboxylase; With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(269505..270572) Shigella dysenteriae Sd197 3799851 YP_401983.1 CDS purE NC_007606.1 270569 271078 R phosphoribosylaminoimidazole carboxylase; Code: F; COG: COG0041; AIR carboxylase, catalytic subunit complement(270569..271078) Shigella dysenteriae Sd197 3799852 YP_401984.1 CDS ybbF NC_007606.1 271196 271918 R ''catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine''; UDP-2,3-diacylglucosamine hydrolase complement(271196..271918) Shigella dysenteriae Sd197 3799853 YP_401985.1 CDS ppiB NC_007606.1 271921 272415 R rotamase B; Code: O; COG: COG0652; peptidyl-prolyl cis-trans isomerase B complement(271921..272415) Shigella dysenteriae Sd197 3799854 YP_401986.1 CDS cysS NC_007606.1 272589 273974 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 272589..273974 Shigella dysenteriae Sd197 3799855 YP_401988.1 CDS ybcJ NC_007606.1 274483 274872 R Code: S; COG: COG2501; hypothetical protein complement(274483..274872) Shigella dysenteriae Sd197 3799857 YP_401989.1 CDS folD NC_007606.1 274853 275719 R 5,10-methylene-tetrahydrofolate cyclohydrolase; Code: H; COG: COG0190; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(274853..275719) Shigella dysenteriae Sd197 3799858 YP_401990.1 CDS insA NC_007606.1 276328 276603 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(276328..276603) Shigella dysenteriae Sd197 3799859 YP_401991.1 CDS SDY_0283 NC_007606.1 276714 277427 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(276714..277427) Shigella dysenteriae Sd197 3799860 YP_401992.1 CDS SDY_0284 NC_007606.1 277568 277870 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(277568..277870) Shigella dysenteriae Sd197 3799861 YP_401994.1 CDS ybaX NC_007606.1 279904 280599 D ''YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His''; queuosine biosynthesis protein QueC 279904..280599 Shigella dysenteriae Sd197 3798960 YP_401995.1 CDS ybaW NC_007606.1 280651 281049 R Code: R; COG: COG0824; hypothetical protein complement(280651..281049) Shigella dysenteriae Sd197 3798961 YP_009000632.1 CDS SDY_0288a NC_007606.1 281510 281782 R insertion element iso-IS1N protein InsA complement(281510..281782) Shigella dysenteriae Sd197 18262947 YP_401998.1 CDS ybaV NC_007606.1 281930 282301 R Code: L; COG: COG1555; hypothetical protein complement(281930..282301) Shigella dysenteriae Sd197 3798964 YP_401999.1 CDS ybaU NC_007606.1 282452 284323 R Code: O; COG: COG0760; peptidyl-prolyl cis-trans isomerase complement(282452..284323) Shigella dysenteriae Sd197 3798965 YP_402000.1 CDS hupB NC_007606.1 284515 284787 R NS1 (HU-1); histone-like DNA-binding protein; transcriptional regulator HU subunit beta complement(284515..284787) Shigella dysenteriae Sd197 3798966 YP_402001.1 CDS lon NC_007606.1 284921 287359 R heat shock K-protein; Code: O; COG: COG0466; DNA-binding ATP-dependent protease La complement(284921..287359) Shigella dysenteriae Sd197 3798967 YP_402002.1 CDS clpX NC_007606.1 287547 288821 R chaperone; binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(287547..288821) Shigella dysenteriae Sd197 3798968 YP_402003.1 CDS clpP NC_007606.1 288947 289570 R heat shock protein F21.5; ''hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates''; ATP-dependent Clp protease proteolytic subunit complement(288947..289570) Shigella dysenteriae Sd197 3798969 YP_402004.1 CDS tig NC_007606.1 289815 291113 R a molecular chaperone involved in cell division; Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor complement(289815..291113) Shigella dysenteriae Sd197 3798970 YP_402006.2 CDS bolA NC_007606.1 291457 291774 R ''positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress''; transcriptional regulator BolA complement(291457..291774) Shigella dysenteriae Sd197 3798972 YP_402007.2 CDS yajG NC_007606.1 292079 292657 D Code: M; COG: COG3056; hypothetical protein 292079..292657 Shigella dysenteriae Sd197 3798973 YP_402008.1 CDS ampG NC_007606.1 292701 294176 D in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 292701..294176 Shigella dysenteriae Sd197 3798974 YP_402009.1 CDS SDY_0301 NC_007606.1 294273 294668 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(294273..294668) Shigella dysenteriae Sd197 3798975 YP_009000633.1 CDS SDY_0303a NC_007606.1 294695 294967 R insertion element iso-IS1N protein InsA complement(294695..294967) Shigella dysenteriae Sd197 18262948 YP_402011.1 CDS yajR NC_007606.1 295062 296432 D Code: GEPR; COG: COG0477; transport protein 295062..296432 Shigella dysenteriae Sd197 3798977 YP_402012.2 CDS yajQ NC_007606.1 296560 297051 R nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein complement(296560..297051) Shigella dysenteriae Sd197 3798978 YP_402013.1 CDS apbA NC_007606.1 297219 298130 D involved in thiamin biosynthesis; alternative pyrimidine biosynthesis; ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 297219..298130 Shigella dysenteriae Sd197 3798979 YP_402014.1 CDS thiJ NC_007606.1 298087 298683 D Code: R; COG: COG0693; hypothetical protein 298087..298683 Shigella dysenteriae Sd197 3799690 YP_402015.1 CDS yajK NC_007606.1 298737 300185 R Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI complement(298737..300185) Shigella dysenteriae Sd197 3799691 YP_402016.1 CDS xseB NC_007606.1 300391 300633 D catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 300391..300633 Shigella dysenteriae Sd197 3799692 YP_402017.1 CDS ispA NC_007606.1 300633 301532 D farnesyldiphosphate synthase; Code: H; COG: COG0142; geranyltranstransferase 300633..301532 Shigella dysenteriae Sd197 3799693 YP_402018.1 CDS dxs NC_007606.1 301557 303419 D flavoprotein; catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 301557..303419 Shigella dysenteriae Sd197 3799694 YP_402019.1 CDS yajO NC_007606.1 303474 304448 D Code: C; COG: COG0667; NAD(P)H-dependent xylose reductase 303474..304448 Shigella dysenteriae Sd197 3799695 YP_009000634.1 CDS SDY_0311a NC_007606.1 304526 304798 D insertion element iso-IS1N protein InsA 304526..304798 Shigella dysenteriae Sd197 18262949 YP_402020.1 CDS SDY_0312 NC_007606.1 304825 305220 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 304825..305220 Shigella dysenteriae Sd197 3799696 YP_402021.1 CDS SDY_0313 NC_007606.1 305221 305625 D hypothetical protein 305221..305625 Shigella dysenteriae Sd197 3799697 YP_402022.1 CDS SDY_0314 NC_007606.1 305622 306017 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(305622..306017) Shigella dysenteriae Sd197 3799698 YP_009000635.1 CDS SDY_0314a NC_007606.1 306044 306316 R insertion element iso-IS1N protein InsA complement(306044..306316) Shigella dysenteriae Sd197 18262950 YP_402023.1 CDS SDY_0315 NC_007606.1 306388 306627 D hypothetical protein 306388..306627 Shigella dysenteriae Sd197 3799699 YP_402024.1 CDS pgpA NC_007606.1 306805 307320 R hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A complement(306805..307320) Shigella dysenteriae Sd197 3799700 YP_402025.1 CDS thiL NC_007606.1 307298 308275 R catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase complement(307298..308275) Shigella dysenteriae Sd197 3799701 YP_402026.1 CDS nusB NC_007606.1 308353 308772 R transcription termination; L factor; Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(308353..308772) Shigella dysenteriae Sd197 3799702 YP_402027.1 CDS ribH NC_007606.1 308792 309262 R ''RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not''; 6,7-dimethyl-8-ribityllumazine synthase complement(308792..309262) Shigella dysenteriae Sd197 3799703 YP_402028.1 CDS ribD NC_007606.1 309351 310454 R in pathway of riboflavin synthesis; ''riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil''; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase complement(309351..310454) Shigella dysenteriae Sd197 3799704 YP_402029.1 CDS nrdR NC_007606.1 310458 310907 R Code: K; COG: COG1327; transcriptional regulator NrdR complement(310458..310907) Shigella dysenteriae Sd197 3799705 YP_402030.2 CDS yajI NC_007606.1 311058 311597 D hypothetical protein 311058..311597 Shigella dysenteriae Sd197 3799706 YP_402031.1 CDS tsx NC_007606.1 311896 312780 D receptor of phage T6 and colicin K; Code: M; COG: COG3248; nucleoside channel 311896..312780 Shigella dysenteriae Sd197 3799707 YP_402032.1 CDS yajD NC_007606.1 312957 313304 R Code: V; COG: COG1403; hypothetical protein complement(312957..313304) Shigella dysenteriae Sd197 3799708 YP_402033.1 CDS secF NC_007606.1 313433 314404 R ''forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF''; preprotein translocase subunit SecF complement(313433..314404) Shigella dysenteriae Sd197 3797461 YP_402034.1 CDS secD NC_007606.1 314415 316262 R protein secretion; membrane protein, part of the channel; ''part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane''; preprotein translocase subunit SecD complement(314415..316262) Shigella dysenteriae Sd197 3797462 YP_402035.1 CDS yajC NC_007606.1 316290 316622 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(316290..316622) Shigella dysenteriae Sd197 3797463 YP_402036.1 CDS tgt NC_007606.1 316645 317772 R ''Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)''; queuine tRNA-ribosyltransferase complement(316645..317772) Shigella dysenteriae Sd197 3797464 YP_402037.1 CDS queA NC_007606.1 317827 318897 R synthesis of queuine in tRNA; Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase complement(317827..318897) Shigella dysenteriae Sd197 3797465 YP_009000636.1 CDS SDY_0332a NC_007606.1 320045 320317 D insertion element iso-IS1N protein InsA 320045..320317 Shigella dysenteriae Sd197 18262951 YP_402042.1 CDS proY NC_007606.1 322222 323595 R ''cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation''; proline-specific permease complement(322222..323595) Shigella dysenteriae Sd197 3797471 YP_402043.1 CDS brnQ NC_007606.1 323671 324990 R Code: E; COG: COG1114; branched chain amino acid transport system II carrier protein complement(323671..324990) Shigella dysenteriae Sd197 3797472 YP_402044.1 CDS phoB NC_007606.1 326751 327440 R sensor is PhoR (or CreC); two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB complement(326751..327440) Shigella dysenteriae Sd197 3797474 YP_402045.1 CDS SDY_0340 NC_007606.1 328417 329763 R Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG complement(328417..329763) Shigella dysenteriae Sd197 3797476 YP_402046.1 CDS sbcC NC_007606.1 330267 333404 D with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease SbcC 330267..333404 Shigella dysenteriae Sd197 3797477 YP_402047.2 CDS SDY_0343 NC_007606.1 334611 335006 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 334611..335006 Shigella dysenteriae Sd197 3797479 YP_402048.2 CDS yajF NC_007606.1 335631 336539 R catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase complement(335631..336539) Shigella dysenteriae Sd197 3796843 YP_402049.1 CDS rdgC NC_007606.1 336664 337575 D Required for efficient pilin antigenic variation; recombination associated protein 336664..337575 Shigella dysenteriae Sd197 3797480 YP_402050.1 CDS SDY_0346 NC_007606.1 337653 338108 R hypothetical protein complement(337653..338108) Shigella dysenteriae Sd197 3796844 YP_402051.1 CDS SDY_0347 NC_007606.1 338249 338644 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(338249..338644) Shigella dysenteriae Sd197 3796845 YP_009000637.1 CDS SDY_0347a NC_007606.1 338671 338943 R insertion element iso-IS1N protein InsA complement(338671..338943) Shigella dysenteriae Sd197 18262952 YP_402053.1 CDS SDY_0349 NC_007606.1 340068 340433 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 340068..340433 Shigella dysenteriae Sd197 3796847 YP_402054.2 CDS SDY_0350 NC_007606.1 340391 341296 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 340391..341296 Shigella dysenteriae Sd197 3796848 YP_009000638.1 CDS SDY_0350a NC_007606.1 341547 341819 D insertion element iso-IS1N protein InsA 341547..341819 Shigella dysenteriae Sd197 18262953 YP_402055.1 CDS SDY_0351 NC_007606.1 342028 342243 D insertion element iso-IS1n protein InsB 342028..342243 Shigella dysenteriae Sd197 3796849 YP_402056.1 CDS yaiE NC_007606.1 342329 342613 R Code: S; COG: COG3123; hypothetical protein complement(342329..342613) Shigella dysenteriae Sd197 3796850 YP_402057.1 CDS aroM NC_007606.1 342685 343362 R regulated by aroR; hypothetical protein complement(342685..343362) Shigella dysenteriae Sd197 3796851 YP_402058.1 CDS yaiA NC_007606.1 343620 343811 R hypothetical protein complement(343620..343811) Shigella dysenteriae Sd197 3796852 YP_402059.1 CDS aroL NC_007606.1 343861 344385 R type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase complement(343861..344385) Shigella dysenteriae Sd197 3796853 YP_402060.2 CDS yaiI NC_007606.1 344568 345026 R Code: S; COG: COG1671; hypothetical protein complement(344568..345026) Shigella dysenteriae Sd197 3796855 YP_402061.1 CDS proC NC_007606.1 345146 345955 D catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 345146..345955 Shigella dysenteriae Sd197 3796854 YP_402062.1 CDS adrA NC_007606.1 345972 347087 R ''catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis''; diguanylate cyclase AdrA complement(345972..347087) Shigella dysenteriae Sd197 3796856 YP_402063.1 CDS SDY_0359 NC_007606.1 347269 347982 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(347269..347982) Shigella dysenteriae Sd197 3796857 YP_402064.1 CDS psiF NC_007606.1 348519 348794 R induced by phosphate starvation complement(348519..348794) Shigella dysenteriae Sd197 3796858 YP_009000639.1 CDS SDY_0360a NC_007606.1 350377 350649 D insertion element iso-IS1N protein InsA 350377..350649 Shigella dysenteriae Sd197 18262954 YP_402065.1 CDS SDY_0362 NC_007606.1 350676 351071 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 350676..351071 Shigella dysenteriae Sd197 3796860 YP_402066.1 CDS yaiB NC_007606.1 351184 351444 R hypothetical protein complement(351184..351444) Shigella dysenteriae Sd197 3796861 YP_402067.1 CDS SDY_0364 NC_007606.1 351496 351891 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(351496..351891) Shigella dysenteriae Sd197 3799557 YP_009000640.1 CDS SDY_0365a NC_007606.1 351918 352190 R insertion element iso-IS1N protein InsA complement(351918..352190) Shigella dysenteriae Sd197 18262955 YP_402068.1 CDS ddl NC_007606.1 352680 353774 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 352680..353774 Shigella dysenteriae Sd197 3799558 YP_402069.1 CDS SDY_0366 NC_007606.1 353798 354142 R hypothetical protein complement(353798..354142) Shigella dysenteriae Sd197 3799559 YP_402070.1 CDS SDY_0367 NC_007606.1 354270 354578 D hypothetical protein 354270..354578 Shigella dysenteriae Sd197 3799560 YP_402071.1 CDS yaiW NC_007606.1 354637 355731 R hypothetical protein complement(354637..355731) Shigella dysenteriae Sd197 3799561 YP_402072.1 CDS sbmA NC_007606.1 355744 356964 R possible envelop protein; ''in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope''; transporter complement(355744..356964) Shigella dysenteriae Sd197 3799562 YP_402073.1 CDS yaiH NC_007606.1 357316 358485 D this protein has no known enzymatic function; beta-lactam binding protein AmpH 357316..358485 Shigella dysenteriae Sd197 3799563 YP_402074.1 CDS SDY_0371 NC_007606.1 358474 358707 R hypothetical protein complement(358474..358707) Shigella dysenteriae Sd197 3799564 YP_009000641.1 CDS SDY_0371a NC_007606.1 358871 359143 D insertion element iso-IS1N protein InsA 358871..359143 Shigella dysenteriae Sd197 18262956 YP_402075.1 CDS SDY_0372 NC_007606.1 359170 359565 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 359170..359565 Shigella dysenteriae Sd197 3799565 YP_402076.1 CDS yaiV NC_007606.1 359575 359916 R hypothetical protein complement(359575..359916) Shigella dysenteriae Sd197 3799566 YP_402077.1 CDS insB NC_007606.1 360005 360382 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(360005..360382) Shigella dysenteriae Sd197 3799567 YP_402078.1 CDS insA NC_007606.1 360427 360702 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(360427..360702) Shigella dysenteriae Sd197 3799568 YP_009000642.1 CDS SDY_0375a NC_007606.1 361181 361453 D insertion element iso-IS1N protein InsA 361181..361453 Shigella dysenteriae Sd197 18262957 YP_402079.2 CDS SDY_0377 NC_007606.1 361480 361875 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 361480..361875 Shigella dysenteriae Sd197 3799570 YP_402081.1 CDS lacI NC_007606.1 365263 366345 R transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor complement(365263..366345) Shigella dysenteriae Sd197 3799572 YP_402082.1 CDS SDY_0380 NC_007606.1 366382 366864 R hypothetical protein complement(366382..366864) Shigella dysenteriae Sd197 3799573 YP_402083.1 CDS SDY_0381 NC_007606.1 366880 367182 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 366880..367182 Shigella dysenteriae Sd197 3799574 YP_402084.1 CDS SDY_0382 NC_007606.1 367323 368036 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 367323..368036 Shigella dysenteriae Sd197 3799575 YP_402085.1 CDS cof NC_007606.1 368064 368510 D Code: R; COG: COG0561; hypothetical protein 368064..368510 Shigella dysenteriae Sd197 3799576 YP_402086.1 CDS ybaO NC_007606.1 368576 369121 D Code: K; COG: COG1522; LRP-like transcriptional regulator 368576..369121 Shigella dysenteriae Sd197 3799577 YP_402087.1 CDS mdlA NC_007606.1 369151 370923 D Code: V; COG: COG1132; multidrug transporter membrane protein/ATP-binding protein 369151..370923 Shigella dysenteriae Sd197 3799578 YP_402088.1 CDS mdlB NC_007606.1 370916 372697 D Code: V; COG: COG1132; multidrug transporter membrane protein/ATP-binding protein 370916..372697 Shigella dysenteriae Sd197 3799579 YP_402089.1 CDS glnK NC_007606.1 372878 373216 D ''indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.''; nitrogen regulatory protein P-II 2 372878..373216 Shigella dysenteriae Sd197 3799580 YP_402090.1 CDS amtB NC_007606.1 373246 374532 D Code: P; COG: COG0004; ammonium transporter 373246..374532 Shigella dysenteriae Sd197 3799581 YP_402091.1 CDS tesB NC_007606.1 374581 375441 R Code: I; COG: COG1946; acyl-CoA thioesterase complement(374581..375441) Shigella dysenteriae Sd197 3799582 YP_402092.1 CDS ybaZ NC_007606.1 376262 376651 R Code: L; COG: COG3695; hypothetical protein complement(376262..376651) Shigella dysenteriae Sd197 3799584 YP_402093.1 CDS ybaA NC_007606.1 376952 377305 D Code: S; COG: COG5507; hypothetical protein 376952..377305 Shigella dysenteriae Sd197 3799585 YP_402094.1 CDS ylaB NC_007606.1 377347 378660 R Code: T; COG: COG4943; hypothetical protein complement(377347..378660) Shigella dysenteriae Sd197 3799586 YP_402095.1 CDS insA NC_007606.1 378730 379005 D Code: L; COG: COG3677; insertion element IS1 protein InsA 378730..379005 Shigella dysenteriae Sd197 3799587 YP_402096.1 CDS gcl NC_007606.1 379362 380921 R Code: R; COG: COG3960; glyoxylate carboligase complement(379362..380921) Shigella dysenteriae Sd197 3799588 YP_402097.1 CDS ybbU NC_007606.1 381011 381826 R regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR complement(381011..381826) Shigella dysenteriae Sd197 3799589 YP_402098.1 CDS ybbT NC_007606.1 381904 382386 R catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase complement(381904..382386) Shigella dysenteriae Sd197 3799590 YP_402099.1 CDS ybbS NC_007606.1 382615 383541 D activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS 382615..383541 Shigella dysenteriae Sd197 3799591 YP_402100.1 CDS ybbB NC_007606.1 383610 384704 D catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 383610..384704 Shigella dysenteriae Sd197 3799592 YP_402101.1 CDS SDY_0400 NC_007606.1 384784 385191 D hypothetical protein 384784..385191 Shigella dysenteriae Sd197 3799593 YP_402102.1 CDS insA NC_007606.1 385896 386171 D Code: L; COG: COG3677; insertion element IS1 protein InsA 385896..386171 Shigella dysenteriae Sd197 3799594 YP_402103.1 CDS insB NC_007606.1 386216 386593 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 386216..386593 Shigella dysenteriae Sd197 3799595 YP_402104.1 CDS ybbA NC_007606.1 389100 389786 R Code: Q; COG: COG4181; ABC transporter ATP-binding protein YbbA complement(389100..389786) Shigella dysenteriae Sd197 3796152 YP_402105.1 CDS tesA NC_007606.1 389754 390380 D also functions as protease I; Code: E; COG: COG2755; multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 389754..390380 Shigella dysenteriae Sd197 3796151 YP_402106.1 CDS ybbO NC_007606.1 390370 391179 D Code: IQR; COG: COG1028; short chain dehydrogenase 390370..391179 Shigella dysenteriae Sd197 3796153 YP_402107.1 CDS ybbN NC_007606.1 391204 392094 D Code: O; COG: COG3118; thioredoxin-like protein 391204..392094 Shigella dysenteriae Sd197 3796154 YP_402108.1 CDS ybbM NC_007606.1 392157 392963 R Code: R; COG: COG0390; metal resistance protein complement(392157..392963) Shigella dysenteriae Sd197 3796155 YP_402109.1 CDS ybbL NC_007606.1 392923 393600 R Code: R; COG: COG4619; ABC transporter ATP-binding protein YbbL complement(392923..393600) Shigella dysenteriae Sd197 3796156 YP_402110.1 CDS ybbK NC_007606.1 393746 394663 D Code: O; COG: COG0330; protease 393746..394663 Shigella dysenteriae Sd197 3796157 YP_402111.1 CDS ybbJ NC_007606.1 394660 395118 D Code: OU; COG: COG1585; hypothetical protein 394660..395118 Shigella dysenteriae Sd197 3796158 YP_402112.1 CDS SDY_0412 NC_007606.1 395198 395560 R hypothetical protein complement(395198..395560) Shigella dysenteriae Sd197 3796159 YP_009000643.1 CDS SDY_0413a NC_007606.1 396353 396625 D insertion element iso-IS1N protein InsA 396353..396625 Shigella dysenteriae Sd197 18262958 YP_402114.1 CDS SDY_0414 NC_007606.1 396652 397047 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 396652..397047 Shigella dysenteriae Sd197 3796161 YP_402115.1 CDS ybbI NC_007606.1 397196 397603 R activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR complement(397196..397603) Shigella dysenteriae Sd197 3796162 YP_402116.1 CDS SDY_0416 NC_007606.1 397600 398775 R Code: M; COG: COG0845; membrane spanning export protein complement(397600..398775) Shigella dysenteriae Sd197 3796163 YP_402117.1 CDS SDY_0417 NC_007606.1 398772 400298 R Code: V; COG: COG2274; cytoplasmic membrane export protein complement(398772..400298) Shigella dysenteriae Sd197 3796164 YP_009000644.1 CDS SDY_0427a NC_007606.1 415932 416204 D insertion element iso-IS1N protein InsA 415932..416204 Shigella dysenteriae Sd197 18262959 YP_402127.1 CDS SDY_0427 NC_007606.1 416231 416626 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 416231..416626 Shigella dysenteriae Sd197 3799097 YP_402130.1 CDS insA NC_007606.1 417654 417929 D Code: L; COG: COG3677; insertion element IS1 protein InsA 417654..417929 Shigella dysenteriae Sd197 3799100 YP_009000645.1 CDS insB NC_007606.1 417974 418351 D insertion element iso-IS1d protein InsB 417974..418351 Shigella dysenteriae Sd197 3799101 YP_402132.1 CDS ybaT NC_007606.1 418512 419804 R Code: E; COG: COG0531; amino acid/amine transport protein complement(418512..419804) Shigella dysenteriae Sd197 3799102 YP_402133.1 CDS copA NC_007606.1 421002 423506 D Code: P; COG: COG2217; copper exporting ATPase 421002..423506 Shigella dysenteriae Sd197 3799104 YP_402134.1 CDS ybaQ NC_007606.1 423620 424015 R Code: R; COG: COG3093; hypothetical protein complement(423620..424015) Shigella dysenteriae Sd197 3799105 YP_402135.1 CDS ybaP NC_007606.1 424099 424893 D Code: S; COG: COG3735; ligase 424099..424893 Shigella dysenteriae Sd197 3799106 YP_402136.1 CDS ybaK NC_007606.1 425097 425576 D Code: S; COG: COG2606; hypothetical protein 425097..425576 Shigella dysenteriae Sd197 3799107 YP_402137.1 CDS ushA NC_007606.1 425613 427265 R 5'-nucleotidase; ''catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides''; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic complement(425613..427265) Shigella dysenteriae Sd197 3799108 YP_402138.1 CDS SDY_0440 NC_007606.1 427709 429055 R Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG complement(427709..429055) Shigella dysenteriae Sd197 3799110 YP_402139.1 CDS ybaL NC_007606.1 430380 432056 D YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein 430380..432056 Shigella dysenteriae Sd197 3799111 YP_402140.1 CDS gsk NC_007606.1 432190 433494 R Code: G; COG: COG0524; inosine-guanosine kinase complement(432190..433494) Shigella dysenteriae Sd197 3798060 YP_402141.1 CDS hemH NC_007606.1 434602 435564 R final enzyme of heme biosynthesis; protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase complement(434602..435564) Shigella dysenteriae Sd197 3798062 YP_402142.1 CDS adk NC_007606.1 435696 436340 R adenylate kinase activity; pleiotropic effects on glycerol-3-phosphate acyltransferase activity; essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase complement(435696..436340) Shigella dysenteriae Sd197 3798063 YP_402143.1 CDS htpG NC_007606.1 436521 438395 R heat shock protein C 62.5; molecular chaperone; heat shock protein 90 complement(436521..438395) Shigella dysenteriae Sd197 3798064 YP_402144.1 CDS recR NC_007606.1 438505 439110 R ''involved in a recombinational process of DNA repair, independent of the recBC complex''; recombination protein RecR complement(438505..439110) Shigella dysenteriae Sd197 3798065 YP_402145.1 CDS ybaB NC_007606.1 439110 439439 R Code: S; COG: COG0718; hypothetical protein complement(439110..439439) Shigella dysenteriae Sd197 3798066 YP_402146.1 CDS dnaX NC_007606.1 439492 441423 R DNA elongation factor III; ''catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA''; DNA polymerase III subunits gamma and tau complement(439492..441423) Shigella dysenteriae Sd197 3798067 YP_402147.1 CDS apt NC_007606.1 441552 442103 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(441552..442103) Shigella dysenteriae Sd197 3798068 YP_402148.1 CDS ybaN NC_007606.1 442256 442633 R Code: S; COG: COG2832; hypothetical protein complement(442256..442633) Shigella dysenteriae Sd197 3798069 YP_402149.1 CDS priC NC_007606.1 442703 443230 D ''PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks''; primosomal replication protein N'' 442703..443230 Shigella dysenteriae Sd197 3798070 YP_402150.1 CDS ybaM NC_007606.1 443244 443408 D hypothetical protein 443244..443408 Shigella dysenteriae Sd197 3798071 YP_402151.1 CDS aefA NC_007606.1 443447 446809 R small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA complement(443447..446809) Shigella dysenteriae Sd197 3798072 YP_402152.1 CDS acrR NC_007606.1 446937 447584 R regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR complement(446937..447584) Shigella dysenteriae Sd197 3798073 YP_402153.1 CDS acrA NC_007606.1 447726 448919 D Code: M; COG: COG0845; acridine efflux pump 447726..448919 Shigella dysenteriae Sd197 3798074 YP_402154.1 CDS acrB NC_007606.1 448942 452091 D Code: V; COG: COG0841; acridine efflux pump 448942..452091 Shigella dysenteriae Sd197 3798075 YP_402155.1 CDS ybaJ NC_007606.1 452637 453011 D hypothetical protein 452637..453011 Shigella dysenteriae Sd197 3798076 YP_402156.1 CDS hha NC_007606.1 453037 453255 D with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 453037..453255 Shigella dysenteriae Sd197 3798077 YP_402157.1 CDS ylaD NC_007606.1 453427 453978 D Code: R; COG: COG0110; maltose O-acetyltransferase 453427..453978 Shigella dysenteriae Sd197 3798078 YP_402158.1 CDS ylaC NC_007606.1 454055 454564 D hypothetical protein 454055..454564 Shigella dysenteriae Sd197 3798079 YP_402159.1 CDS SDY_0462 NC_007606.1 454728 454928 D hypothetical protein 454728..454928 Shigella dysenteriae Sd197 3796170 YP_402160.1 CDS SDY_0463 NC_007606.1 455017 455382 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 455017..455382 Shigella dysenteriae Sd197 3796171 YP_402161.2 CDS SDY_0464 NC_007606.1 455340 456245 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 455340..456245 Shigella dysenteriae Sd197 3796172 YP_402162.1 CDS insB NC_007606.1 456311 456688 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(456311..456688) Shigella dysenteriae Sd197 3796173 YP_402163.1 CDS insA NC_007606.1 456733 457008 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(456733..457008) Shigella dysenteriae Sd197 3796174 YP_402164.1 CDS SDY_0467 NC_007606.1 457321 457623 D Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 457321..457623 Shigella dysenteriae Sd197 3796175 YP_009000646.1 CDS SDY_0470a NC_007606.1 458669 458941 D insertion element iso-IS1N protein InsA 458669..458941 Shigella dysenteriae Sd197 18262960 YP_402167.1 CDS SDY_0470 NC_007606.1 458968 459363 D Code: L; COG: COG1662; insertion element IS1 protein InsB 458968..459363 Shigella dysenteriae Sd197 3796178 YP_402169.1 CDS proA NC_007606.1 460593 461846 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(460593..461846) Shigella dysenteriae Sd197 3796181 YP_402170.1 CDS proB NC_007606.1 461858 462961 R catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase complement(461858..462961) Shigella dysenteriae Sd197 3796182 YP_402171.1 CDS insA NC_007606.1 463189 463464 D Code: L; COG: COG3677; insertion element IS1 protein InsA 463189..463464 Shigella dysenteriae Sd197 3796183 YP_402172.1 CDS insB NC_007606.1 463509 463886 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 463509..463886 Shigella dysenteriae Sd197 3796184 YP_402173.1 CDS crl NC_007606.1 463961 464362 R transcriptional regulator of cryptic csgA gene for curli surface fibers; involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl complement(463961..464362) Shigella dysenteriae Sd197 3796185 YP_402174.1 CDS frsA NC_007606.1 464420 465664 R forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein complement(464420..465664) Shigella dysenteriae Sd197 3796186 YP_402175.1 CDS gpt NC_007606.1 465756 466214 R ''catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively''; xanthine-guanine phosphoribosyltransferase complement(465756..466214) Shigella dysenteriae Sd197 3796187 YP_402176.1 CDS pepD NC_007606.1 466475 467932 D peptidase D; Code: E; COG: COG2195; aminoacyl-histidine dipeptidase 466475..467932 Shigella dysenteriae Sd197 3796079 YP_402177.1 CDS prfH NC_007606.1 467989 468489 R peptide chain release factor-like protein complement(467989..468489) Shigella dysenteriae Sd197 3796080 YP_402178.1 CDS SDY_0482 NC_007606.1 468458 468724 R Code: S; COG: COG1690; hypothetical protein complement(468458..468724) Shigella dysenteriae Sd197 3796081 YP_402179.1 CDS dinP NC_007606.1 469480 470535 R tRNA synthetase; involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(469480..470535) Shigella dysenteriae Sd197 3796082 YP_402180.1 CDS mbhA NC_007606.1 470606 471385 R Code: N; COG: COG1360; hypothetical protein complement(470606..471385) Shigella dysenteriae Sd197 3796083 YP_402181.1 CDS SDY_0485 NC_007606.1 471532 472275 R Code: N; COG: COG1291; flagellar motor transmembrane channel protein complement(471532..472275) Shigella dysenteriae Sd197 3796084 YP_009000647.1 CDS SDY_0485a NC_007606.1 472198 472470 D insertion element iso-IS1N protein InsA 472198..472470 Shigella dysenteriae Sd197 18262961 YP_402182.1 CDS SDY_0486 NC_007606.1 472497 472892 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 472497..472892 Shigella dysenteriae Sd197 3796085 YP_402183.1 CDS insA NC_007606.1 473162 473449 D Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 473162..473449 Shigella dysenteriae Sd197 3796086 YP_402184.1 CDS SDY_0488 NC_007606.1 473945 475327 D hypothetical protein 473945..475327 Shigella dysenteriae Sd197 3796087 YP_402185.1 CDS pheP NC_007606.1 475429 476805 D Code: E; COG: COG1113; phenylalanine transporter 475429..476805 Shigella dysenteriae Sd197 3796088 YP_402186.1 CDS ybdG NC_007606.1 476873 478120 R Code: M; COG: COG0668; transporter complement(476873..478120) Shigella dysenteriae Sd197 3796089 YP_402187.1 CDS nfnB NC_007606.1 478228 478881 R ''catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive''; dihydropteridine reductase complement(478228..478881) Shigella dysenteriae Sd197 3796090 YP_402188.1 CDS ybdF NC_007606.1 478975 479343 R Code: S; COG: COG2315; hypothetical protein complement(478975..479343) Shigella dysenteriae Sd197 3796091 YP_402189.1 CDS ybdJ NC_007606.1 479408 479656 R hypothetical protein complement(479408..479656) Shigella dysenteriae Sd197 3796092 YP_402190.1 CDS ybdK NC_007606.1 479722 480840 R ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase complement(479722..480840) Shigella dysenteriae Sd197 3796093 YP_009000648.1 CDS SDY_0495a NC_007606.1 481279 481431 D toxic polypeptide 481279..481431 Shigella dysenteriae Sd197 18262962 YP_402191.2 CDS SDY_0495 NC_007606.1 481764 482669 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(481764..482669) Shigella dysenteriae Sd197 3796094 YP_402192.1 CDS SDY_0496 NC_007606.1 482627 482992 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(482627..482992) Shigella dysenteriae Sd197 3796095 YP_402193.1 CDS SDY_0497 NC_007606.1 483003 483995 D hypothetical protein 483003..483995 Shigella dysenteriae Sd197 3796096 YP_402194.1 CDS SDY_0498 NC_007606.1 484134 484817 D hypothetical protein 484134..484817 Shigella dysenteriae Sd197 3796097 YP_402195.1 CDS insA NC_007606.1 484868 485143 D Code: L; COG: COG3677; insertion element IS1 protein InsA 484868..485143 Shigella dysenteriae Sd197 3796098 YP_402196.1 CDS insB NC_007606.1 485188 485565 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 485188..485565 Shigella dysenteriae Sd197 3797427 YP_402197.1 CDS hemB NC_007606.1 485847 486854 D porphobilinogen synthase; catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 485847..486854 Shigella dysenteriae Sd197 3797428 YP_402198.1 CDS tauD NC_007606.1 486961 487812 R 2-oxoglutarate-dependent; catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase complement(486961..487812) Shigella dysenteriae Sd197 3797429 YP_402199.1 CDS tauC NC_007606.1 487809 488636 R Code: P; COG: COG0600; taurine transporter subunit complement(487809..488636) Shigella dysenteriae Sd197 3797430 YP_402200.1 CDS tauB NC_007606.1 488633 489400 R Part of the ABC transporter complex tauABC involved in taurine import; taurine ABC transporter ATP-binding protein complement(488633..489400) Shigella dysenteriae Sd197 3797431 YP_402201.1 CDS tauA NC_007606.1 489413 490375 R with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit complement(489413..490375) Shigella dysenteriae Sd197 3797432 YP_402202.1 CDS SDY_0506 NC_007606.1 490678 491307 D hexosephosphate transport; Code: TK; COG: COG2197; response regulator 490678..491307 Shigella dysenteriae Sd197 3797433 YP_402206.1 CDS SDY_0510 NC_007606.1 493226 493591 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(493226..493591) Shigella dysenteriae Sd197 3797437 YP_009000649.1 CDS SDY_0510a NC_007606.1 493717 493869 D toxic polypeptide 493717..493869 Shigella dysenteriae Sd197 18262963 YP_402207.1 CDS entD NC_007606.1 493991 494620 R Code: Q; COG: COG2977; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex complement(493991..494620) Shigella dysenteriae Sd197 3797438 YP_402208.1 CDS fepA NC_007606.1 494786 497026 R Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA complement(494786..497026) Shigella dysenteriae Sd197 3797439 YP_402209.1 CDS fes NC_007606.1 497347 498471 D Code: P; COG: COG2382; enterobactin/ferric enterobactin esterase 497347..498471 Shigella dysenteriae Sd197 3797440 YP_402210.1 CDS ybdZ NC_007606.1 498474 498692 D Code: S; COG: COG3251; hypothetical protein 498474..498692 Shigella dysenteriae Sd197 3797441 YP_402211.1 CDS entF NC_007606.1 498689 502570 D may be part of enterobactin synthase as component F; ''with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin''; enterobactin synthase subunit F 498689..502570 Shigella dysenteriae Sd197 3797442 YP_009000650.1 CDS insB NC_007606.1 502790 503167 R insertion element iso-IS1d protein InsB complement(502790..503167) Shigella dysenteriae Sd197 3797443 YP_402213.1 CDS insA NC_007606.1 503212 503487 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(503212..503487) Shigella dysenteriae Sd197 3797444 YP_402214.1 CDS fepE NC_007606.1 503562 504695 D enterochelin transport; part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 503562..504695 Shigella dysenteriae Sd197 3797445 YP_402215.1 CDS fepC NC_007606.1 504692 505507 R with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin ABC transporter ATP-binding protein complement(504692..505507) Shigella dysenteriae Sd197 3799884 YP_402216.1 CDS fepG NC_007606.1 505504 506496 R with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin ABC transporter permease complement(505504..506496) Shigella dysenteriae Sd197 3799885 YP_402217.1 CDS fepD NC_007606.1 506493 507497 R enterochelin transport; with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin ABC transporter permease complement(506493..507497) Shigella dysenteriae Sd197 3799886 YP_402218.1 CDS ybdA NC_007606.1 507608 508858 D protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 507608..508858 Shigella dysenteriae Sd197 3799887 YP_402219.1 CDS fepB NC_007606.1 508939 509904 R enterochelin binding protein; periplasmic component; with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin ABC transporter substrate-binding protein complement(508939..509904) Shigella dysenteriae Sd197 3799888 YP_402220.1 CDS entC NC_007606.1 510093 511268 D enterochelin biosynthesis; Code: HQ; COG: COG1169; isochorismate hydroxymutase 510093..511268 Shigella dysenteriae Sd197 3799889 YP_402221.1 CDS entE NC_007606.1 511278 512888 D ''bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate''; enterobactin synthase subunit E 511278..512888 Shigella dysenteriae Sd197 3799890 YP_402222.1 CDS entB NC_007606.1 512902 513759 D isochroismatase; Code: Q; COG: COG1535; 2,3-dihydro-2,3-dihydroxybenzoate synthetase 512902..513759 Shigella dysenteriae Sd197 3799891 YP_402223.1 CDS entA NC_007606.1 513759 514505 D enterochelin biosynthesis; ''catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin''; 2,3-dihydroxybenzoate-2,3-dehydrogenase 513759..514505 Shigella dysenteriae Sd197 3799892 YP_402224.1 CDS ybdB NC_007606.1 514508 514921 D Code: Q; COG: COG2050; hypothetical protein 514508..514921 Shigella dysenteriae Sd197 3799893 YP_402225.1 CDS ybdD NC_007606.1 517389 517586 D Code: S; COG: COG2879; hypothetical protein 517389..517586 Shigella dysenteriae Sd197 3799895 YP_402226.1 CDS ybdH NC_007606.1 517596 518684 R member of the iron-containing alcohol dehydrogenase; unknown function; hypothetical protein complement(517596..518684) Shigella dysenteriae Sd197 3799896 YP_402229.1 CDS SDY_0534 NC_007606.1 520556 521143 R hypothetical protein complement(520556..521143) Shigella dysenteriae Sd197 3799899 YP_402230.1 CDS SDY_0535 NC_007606.1 521209 521511 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 521209..521511 Shigella dysenteriae Sd197 3799900 YP_402231.1 CDS SDY_0536 NC_007606.1 521652 522365 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 521652..522365 Shigella dysenteriae Sd197 3799901 YP_402232.1 CDS ybdN NC_007606.1 522390 523043 R Code: R; COG: COG3969; hypothetical protein complement(522390..523043) Shigella dysenteriae Sd197 3799902 YP_009000651.1 CDS SDY_0537a NC_007606.1 523516 523788 D insertion element iso-IS1N protein InsA 523516..523788 Shigella dysenteriae Sd197 18262964 YP_402233.1 CDS SDY_0538 NC_007606.1 523815 524210 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 523815..524210 Shigella dysenteriae Sd197 3799903 YP_402234.1 CDS ahpC NC_007606.1 525582 526145 D detoxification of hydroperoxides; with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase 525582..526145 Shigella dysenteriae Sd197 3797335 YP_402235.1 CDS ahpF NC_007606.1 526244 527839 D detoxification of hydroperoxides; Code: O; COG: COG3634; alkyl hydroperoxide reductase 526244..527839 Shigella dysenteriae Sd197 3797336 YP_402236.1 CDS ybdQ NC_007606.1 527960 528388 R Code: T; COG: COG0589; hypothetical protein complement(527960..528388) Shigella dysenteriae Sd197 3797337 YP_402237.1 CDS insA NC_007606.1 528601 528876 D Code: L; COG: COG3677; insertion element IS1 protein InsA 528601..528876 Shigella dysenteriae Sd197 3797338 YP_402238.1 CDS insB NC_007606.1 528921 529298 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 528921..529298 Shigella dysenteriae Sd197 3797339 YP_402239.1 CDS pagP NC_007606.1 529510 529782 D catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 529510..529782 Shigella dysenteriae Sd197 3797340 YP_402240.1 CDS cspE NC_007606.1 529957 530166 D member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 529957..530166 Shigella dysenteriae Sd197 3797341 YP_402241.1 CDS crcB NC_007606.1 530220 530603 R Code: D; COG: COG0239; hypothetical protein complement(530220..530603) Shigella dysenteriae Sd197 3797342 YP_402243.1 CDS tatE NC_007606.1 531613 531816 D TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase E 531613..531816 Shigella dysenteriae Sd197 3797344 YP_402244.1 CDS lipA NC_007606.1 531917 532882 R possible sulfur insertion; catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(531917..532882) Shigella dysenteriae Sd197 3797345 YP_402245.1 CDS ybeF NC_007606.1 533091 534026 R Code: K; COG: COG0583; DNA-binding transcriptional regulator complement(533091..534026) Shigella dysenteriae Sd197 3797346 YP_402246.2 CDS lipB NC_007606.1 534439 535080 R lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse; lipoate-protein ligase B; transfers lipoate to apolipoproteins; involved in lipoate metabolism; lipoyltransferase complement(534439..535080) Shigella dysenteriae Sd197 3797347 YP_402247.1 CDS ybeD NC_007606.1 535180 535443 R Code: S; COG: COG2921; hypothetical protein complement(535180..535443) Shigella dysenteriae Sd197 3797348 YP_402248.1 CDS dacA NC_007606.1 535553 536764 R penicillin-binding protein 5; penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase complement(535553..536764) Shigella dysenteriae Sd197 3797349 YP_402249.1 CDS rlpA NC_007606.1 536904 537992 R Code: M; COG: COG0797; rare lipoprotein A complement(536904..537992) Shigella dysenteriae Sd197 3797350 YP_402250.1 CDS mrdB NC_007606.1 538003 539115 R sensitivity to radiation and drugs; Code: D; COG: COG0772; cell wall shape-determining protein complement(538003..539115) Shigella dysenteriae Sd197 3797351 YP_402251.1 CDS mrdA NC_007606.1 539118 541019 R cell elongation, e phase; peptidoglycan synthetase; Code: M; COG: COG0768; penicillin-binding protein 2 complement(539118..541019) Shigella dysenteriae Sd197 3797352 YP_402252.1 CDS ybeA NC_007606.1 541050 541517 R SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(541050..541517) Shigella dysenteriae Sd197 3799672 YP_402253.2 CDS ybeB NC_007606.1 541521 541838 R Code: S; COG: COG0799; hypothetical protein complement(541521..541838) Shigella dysenteriae Sd197 3799673 YP_402254.1 CDS nadD NC_007606.1 542741 543382 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(542741..543382) Shigella dysenteriae Sd197 3799675 YP_402255.1 CDS holA NC_007606.1 543384 544415 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(543384..544415) Shigella dysenteriae Sd197 3799676 YP_402256.1 CDS rlpB NC_007606.1 544415 544996 R rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB complement(544415..544996) Shigella dysenteriae Sd197 3799677 YP_402257.1 CDS leuS NC_007606.1 545011 547593 R ''leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase''; leucyl-tRNA synthetase complement(545011..547593) Shigella dysenteriae Sd197 3799678 YP_402258.1 CDS SDY_0565 NC_007606.1 547792 548094 D Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 547792..548094 Shigella dysenteriae Sd197 3799679 YP_402259.1 CDS SDY_0566 NC_007606.1 548121 548960 D Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein 548121..548960 Shigella dysenteriae Sd197 3799680 YP_402260.1 CDS ybeL NC_007606.1 549081 549563 D hypothetical protein 549081..549563 Shigella dysenteriae Sd197 3799681 YP_402261.1 CDS ybeQ NC_007606.1 549633 550616 R Code: R; COG: COG0790; hypothetical protein complement(549633..550616) Shigella dysenteriae Sd197 3799682 YP_402262.1 CDS insB NC_007606.1 550845 551222 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(550845..551222) Shigella dysenteriae Sd197 3799683 YP_402263.1 CDS insA NC_007606.1 551267 551542 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(551267..551542) Shigella dysenteriae Sd197 3799684 YP_009000652.1 CDS SDY_0572a NC_007606.1 552013 552285 R insertion element iso-IS1N protein InsA complement(552013..552285) Shigella dysenteriae Sd197 18262965 YP_402266.1 CDS SDY_0577 NC_007606.1 553055 553612 R bacteriophage protein complement(553055..553612) Shigella dysenteriae Sd197 3798981 YP_402267.1 CDS SDY_0578 NC_007606.1 553885 554439 R hypothetical protein complement(553885..554439) Shigella dysenteriae Sd197 3798982 YP_402268.1 CDS SDY_0579 NC_007606.1 554436 554726 R bacteriophage protein complement(554436..554726) Shigella dysenteriae Sd197 3798983 YP_402269.1 CDS SDY_0580 NC_007606.1 554933 555538 R hypothetical protein complement(554933..555538) Shigella dysenteriae Sd197 3798984 YP_402270.1 CDS SDY_0581 NC_007606.1 555577 555864 R hypothetical protein complement(555577..555864) Shigella dysenteriae Sd197 3798985 YP_402271.1 CDS SDY_0582 NC_007606.1 555930 556175 R hypothetical protein complement(555930..556175) Shigella dysenteriae Sd197 3798986 YP_402274.1 CDS SDY_0585 NC_007606.1 556949 557251 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(556949..557251) Shigella dysenteriae Sd197 3798989 YP_402275.1 CDS SDY_0586 NC_007606.1 557290 557649 D Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 557290..557649 Shigella dysenteriae Sd197 3798990 YP_402276.1 CDS SDY_0587 NC_007606.1 557676 558515 D Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein 557676..558515 Shigella dysenteriae Sd197 3798991 YP_402277.1 CDS gltK NC_007606.1 558682 559356 R Code: E; COG: COG0765; glutamate/aspartate ABC transporter permease complement(558682..559356) Shigella dysenteriae Sd197 3798992 YP_402278.1 CDS SDY_0590 NC_007606.1 560013 560315 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 560013..560315 Shigella dysenteriae Sd197 3798994 YP_402279.1 CDS SDY_0591 NC_007606.1 560456 561268 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 560456..561268 Shigella dysenteriae Sd197 3798995 YP_402280.1 CDS ybeJ NC_007606.1 561524 562432 R Code: ET; COG: COG0834; glutamate/aspartate ABC transporter substrate-binding protein complement(561524..562432) Shigella dysenteriae Sd197 3798996 YP_402281.1 CDS lnt NC_007606.1 562829 564367 R copper homeostasis protein; inner membrane; Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(562829..564367) Shigella dysenteriae Sd197 3796099 YP_402282.1 CDS ybeX NC_007606.1 564392 565270 R Code: P; COG: COG4535; transport protein complement(564392..565270) Shigella dysenteriae Sd197 3796100 YP_402283.1 CDS ybeY NC_007606.1 565360 565827 R Code: R; COG: COG0319; metalloprotease complement(565360..565827) Shigella dysenteriae Sd197 3796101 YP_402284.1 CDS ybeZ NC_007606.1 565824 566903 R Code: T; COG: COG1702; ATP-binding protein complement(565824..566903) Shigella dysenteriae Sd197 3796102 YP_402285.1 CDS yleA NC_007606.1 567017 568441 R Code: J; COG: COG0621; hypothetical protein complement(567017..568441) Shigella dysenteriae Sd197 3796103 YP_402286.1 CDS ubiF NC_007606.1 568587 569762 D ''catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q''; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 568587..569762 Shigella dysenteriae Sd197 3796104 YP_402290.1 CDS asnB NC_007606.1 570887 572551 R ''functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP''; asparagine synthetase B complement(570887..572551) Shigella dysenteriae Sd197 3798561 YP_402291.1 CDS nagD NC_007606.1 572808 573560 R Code: G; COG: COG0647; UMP phosphatase complement(572808..573560) Shigella dysenteriae Sd197 3798562 YP_402292.1 CDS nagC NC_007606.1 573608 574828 R transcriptional repressor of nag operon; Code: KG; COG: COG1940; N-acetylglucosamine operon transcriptional repressor complement(573608..574828) Shigella dysenteriae Sd197 3798563 YP_402293.1 CDS nagA NC_007606.1 574837 575985 R catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase complement(574837..575985) Shigella dysenteriae Sd197 3798564 YP_402294.1 CDS nagB NC_007606.1 576045 576845 R catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase complement(576045..576845) Shigella dysenteriae Sd197 3798565 YP_402295.1 CDS nagE NC_007606.1 577179 579125 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunit IIABC 577179..579125 Shigella dysenteriae Sd197 3798566 YP_402296.1 CDS glnS NC_007606.1 579328 580992 D ''catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''; glutaminyl-tRNA synthetase 579328..580992 Shigella dysenteriae Sd197 3798567 YP_402297.1 CDS insB NC_007606.1 581099 581476 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(581099..581476) Shigella dysenteriae Sd197 3798568 YP_402298.1 CDS insA NC_007606.1 581521 581826 R Code: L; COG: COG3677; insertion element iso-IS1d protein InsA complement(581521..581826) Shigella dysenteriae Sd197 3798569 YP_402299.1 CDS SDY_0617 NC_007606.1 582091 582486 D Code: L; COG: COG1662; insertion element IS1 protein InsB 582091..582486 Shigella dysenteriae Sd197 3798570 YP_402300.1 CDS SDY_0618 NC_007606.1 582716 583078 D hypothetical protein 582716..583078 Shigella dysenteriae Sd197 3798571 YP_402301.1 CDS insA NC_007606.1 583129 583404 D Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 583129..583404 Shigella dysenteriae Sd197 3798572 YP_402305.1 CDS fur NC_007606.1 585361 585807 R negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator complement(585361..585807) Shigella dysenteriae Sd197 3798576 YP_402306.1 CDS fldA NC_007606.1 586096 586626 R ''An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group''; flavodoxin FldA complement(586096..586626) Shigella dysenteriae Sd197 3798577 YP_402307.1 CDS ybfE NC_007606.1 586766 587128 R LexA regulated protein complement(586766..587128) Shigella dysenteriae Sd197 3798578 YP_402308.1 CDS ybfF NC_007606.1 587199 587963 R Code: R; COG: COG0596; hypothetical protein complement(587199..587963) Shigella dysenteriae Sd197 3799383 YP_402309.1 CDS seqA NC_007606.1 588148 588693 D negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 588148..588693 Shigella dysenteriae Sd197 3799384 YP_402310.1 CDS pgm NC_007606.1 588719 590359 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 588719..590359 Shigella dysenteriae Sd197 3799385 YP_402311.1 CDS kdpE NC_007606.1 590523 591200 R transcriptional effector; response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE complement(590523..591200) Shigella dysenteriae Sd197 3799386 YP_402312.1 CDS kdpC NC_007606.1 593880 594452 R ''One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex''; potassium-transporting ATPase subunit C complement(593880..594452) Shigella dysenteriae Sd197 3799388 YP_402313.1 CDS kdpF NC_007606.1 598183 598272 R potassium ion accessory transporter KdpF complement(598183..598272) Shigella dysenteriae Sd197 3799391 YP_402314.1 CDS ybfA NC_007606.1 598585 598791 D hypothetical protein 598585..598791 Shigella dysenteriae Sd197 3799392 YP_402315.1 CDS rhsC NC_007606.1 599034 602297 D Code: M; COG: COG3209; rhs element protein RhsC 599034..602297 Shigella dysenteriae Sd197 3799393 YP_402316.1 CDS SDY_0637 NC_007606.1 602307 602702 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(602307..602702) Shigella dysenteriae Sd197 3799394 YP_009000653.1 CDS SDY_0637a NC_007606.1 602729 603001 R insertion element iso-IS1N protein InsA complement(602729..603001) Shigella dysenteriae Sd197 18262967 YP_402319.1 CDS SDY_0640 NC_007606.1 603707 604102 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(603707..604102) Shigella dysenteriae Sd197 3799397 YP_009000654.1 CDS SDY_0642a NC_007606.1 604129 604401 R insertion element iso-IS1N protein InsA complement(604129..604401) Shigella dysenteriae Sd197 18262968 YP_402321.1 CDS ybgA NC_007606.1 604976 605485 D Code: S; COG: COG3272; hypothetical protein 604976..605485 Shigella dysenteriae Sd197 3799399 YP_402322.1 CDS phrB NC_007606.1 605482 606900 D photoreactivation; UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 605482..606900 Shigella dysenteriae Sd197 3799400 YP_402323.1 CDS ybgI NC_007606.1 608802 609545 D Code: S; COG: COG0327; hydrolase-oxidase 608802..609545 Shigella dysenteriae Sd197 3799709 YP_402324.1 CDS ybgJ NC_007606.1 609568 610224 D Code: E; COG: COG2049; carboxylase 609568..610224 Shigella dysenteriae Sd197 3799710 YP_402325.1 CDS ybgK NC_007606.1 610218 611150 D Code: E; COG: COG1984; carboxylase 610218..611150 Shigella dysenteriae Sd197 3799711 YP_402326.1 CDS ybgL NC_007606.1 611140 611874 D Code: R; COG: COG1540; LamB/YcsF family protein 611140..611874 Shigella dysenteriae Sd197 3799712 YP_402327.1 CDS nei NC_007606.1 611910 612701 D 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 611910..612701 Shigella dysenteriae Sd197 3799713 YP_402328.1 CDS abrB NC_007606.1 612698 613759 R Code: R; COG: COG3180; transport protein complement(612698..613759) Shigella dysenteriae Sd197 3799714 YP_402329.1 CDS ybgO NC_007606.1 613893 614954 R hypothetical protein complement(613893..614954) Shigella dysenteriae Sd197 3799715 YP_402330.1 CDS ybgP NC_007606.1 614951 615646 R Code: NU; COG: COG3121; chaperone complement(614951..615646) Shigella dysenteriae Sd197 3799716 YP_009000655.1 CDS SDY_0562a NC_007606.1 615569 615841 D insertion element iso-IS1N protein InsA 615569..615841 Shigella dysenteriae Sd197 18262969 YP_402331.1 CDS SDY_0653 NC_007606.1 615868 616263 D Code: L; COG: COG1662; insertion element IS1 protein InsB 615868..616263 Shigella dysenteriae Sd197 3799717 YP_402332.1 CDS ybgD NC_007606.1 618980 619546 R Code: NU; COG: COG3539; fimbrial-like protein complement(618980..619546) Shigella dysenteriae Sd197 3799719 YP_402333.1 CDS insB NC_007606.1 619572 619949 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(619572..619949) Shigella dysenteriae Sd197 3799720 YP_402334.1 CDS insA NC_007606.1 619994 620269 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(619994..620269) Shigella dysenteriae Sd197 3799721 YP_402335.1 CDS gltA NC_007606.1 620710 621993 R ''type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH''; type II citrate synthase complement(620710..621993) Shigella dysenteriae Sd197 3799722 YP_402336.1 CDS sdhC NC_007606.1 622702 623091 D cytochrome b556; Code: C; COG: COG2009; succinate dehydrogenase cytochrome b556 large membrane subunit 622702..623091 Shigella dysenteriae Sd197 3799723 YP_402337.1 CDS sdhD NC_007606.1 623085 623432 D Code: C; COG: COG2142; succinate dehydrogenase cytochrome b556 small membrane subunit 623085..623432 Shigella dysenteriae Sd197 3799724 YP_402338.1 CDS sdhA NC_007606.1 623432 625198 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 623432..625198 Shigella dysenteriae Sd197 3799725 YP_402339.1 CDS sdhB NC_007606.1 625214 625930 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 625214..625930 Shigella dysenteriae Sd197 3799726 YP_402340.1 CDS SDY_0663 NC_007606.1 625989 626249 D hypothetical protein 625989..626249 Shigella dysenteriae Sd197 3799727 YP_402341.1 CDS sucA NC_007606.1 626231 629032 D SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 626231..629032 Shigella dysenteriae Sd197 3799728 YP_402342.1 CDS sucB NC_007606.1 629047 630264 D component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 629047..630264 Shigella dysenteriae Sd197 3799209 YP_402343.1 CDS sucC NC_007606.1 630358 631524 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 630358..631524 Shigella dysenteriae Sd197 3799210 YP_402344.1 CDS sucD NC_007606.1 631524 632393 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 631524..632393 Shigella dysenteriae Sd197 3799211 YP_402345.1 CDS insA NC_007606.1 633099 633374 D Code: L; COG: COG3677; insertion element IS1 protein InsA 633099..633374 Shigella dysenteriae Sd197 3799212 YP_402346.1 CDS insB NC_007606.1 633419 633796 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 633419..633796 Shigella dysenteriae Sd197 3799213 YP_402347.1 CDS insA NC_007606.1 633874 634149 D Code: L; COG: COG3677; insertion element IS1 protein InsA 633874..634149 Shigella dysenteriae Sd197 3799214 YP_402348.1 CDS insB NC_007606.1 634194 634571 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 634194..634571 Shigella dysenteriae Sd197 3799215 YP_402349.1 CDS SDY_0672 NC_007606.1 634675 636045 R hypothetical protein complement(634675..636045) Shigella dysenteriae Sd197 3799216 YP_402350.1 CDS SDY_0673 NC_007606.1 636049 637290 R Code: E; COG: COG3799; methylaspartate ammonia-lyase complement(636049..637290) Shigella dysenteriae Sd197 3799217 YP_402351.1 CDS SDY_0674 NC_007606.1 637290 638654 R Code: E; COG: COG4865; glutamate mutase subunit E complement(637290..638654) Shigella dysenteriae Sd197 3799218 YP_402352.1 CDS SDY_0675 NC_007606.1 638673 640061 R glutamate mutase L complement(638673..640061) Shigella dysenteriae Sd197 3799219 YP_402353.1 CDS SDY_0676 NC_007606.1 640061 640573 R converts methylaspartate to L-glutamate; methylaspartate mutase subunit S complement(640061..640573) Shigella dysenteriae Sd197 3799220 YP_009000656.1 CDS SDY_0676a NC_007606.1 641282 641554 D insertion element iso-IS1N protein InsA 641282..641554 Shigella dysenteriae Sd197 18262970 YP_402357.1 CDS cydA NC_007606.1 644083 645654 D Code: C; COG: COG1271; cytochrome d terminal oxidase polypeptide subunit I 644083..645654 Shigella dysenteriae Sd197 3799224 YP_402358.1 CDS cydB NC_007606.1 645670 646809 D Code: C; COG: COG1294; cytochrome d terminal oxidase polypeptide subunit II 645670..646809 Shigella dysenteriae Sd197 3799225 YP_402359.1 CDS ybgT NC_007606.1 646824 646937 D Code: S; COG: COG4890; outer membrane lipoprotein 646824..646937 Shigella dysenteriae Sd197 3799226 YP_402360.1 CDS ybgE NC_007606.1 646937 647230 D Code: S; COG: COG3790; hypothetical protein 646937..647230 Shigella dysenteriae Sd197 3799227 YP_402361.1 CDS ybgC NC_007606.1 647380 647784 D catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase 647380..647784 Shigella dysenteriae Sd197 3796634 YP_402362.1 CDS tolQ NC_007606.1 647781 648473 D membrane-spanning; maintains integrity of cell envelope; tolerance to group A colicins; membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 647781..648473 Shigella dysenteriae Sd197 3796635 YP_402363.1 CDS tolR NC_007606.1 648477 648905 D involved in the tonB-independent uptake of group A colicins; membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 648477..648905 Shigella dysenteriae Sd197 3796636 YP_402364.1 CDS tolA NC_007606.1 648970 650235 D required for outer membrane integrity; ''inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins''; cell envelope integrity inner membrane protein TolA 648970..650235 Shigella dysenteriae Sd197 3796637 YP_402365.1 CDS tolB NC_007606.1 650368 651660 D involved in the tonb-independent uptake of group A colicins; forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 650368..651660 Shigella dysenteriae Sd197 3796638 YP_402366.1 CDS pal NC_007606.1 651695 652216 D Code: M; COG: COG2885; peptidoglycan-associated outer membrane lipoprotein 651695..652216 Shigella dysenteriae Sd197 3796639 YP_402367.1 CDS ybgF NC_007606.1 652226 653017 D periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 652226..653017 Shigella dysenteriae Sd197 3796640 YP_402368.1 CDS nadA NC_007606.1 653866 654909 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 653866..654909 Shigella dysenteriae Sd197 3796644 YP_402369.1 CDS pnuC NC_007606.1 654947 655666 D Code: H; COG: COG3201; nicotinamide mononucleotide transporter PnuC 654947..655666 Shigella dysenteriae Sd197 3796645 YP_402370.1 CDS ybgR NC_007606.1 655663 656604 R involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB complement(655663..656604) Shigella dysenteriae Sd197 3796646 YP_402371.1 CDS SDY_0697 NC_007606.1 656718 657098 R homeobox protein complement(656718..657098) Shigella dysenteriae Sd197 3796647 YP_009000657.1 CDS SDY_0699a NC_007606.1 657364 657636 D insertion element iso-IS1N protein InsA 657364..657636 Shigella dysenteriae Sd197 18262971 YP_402375.1 CDS aroG NC_007606.1 658187 659239 D DAHP synthetase; phenylalanine repressible; ''catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive''; phospho-2-dehydro-3-deoxyheptonate aldolase 658187..659239 Shigella dysenteriae Sd197 3799479 YP_402376.1 CDS gpmA NC_007606.1 659398 660150 R Code: G; COG: COG0588; phosphoglyceromutase complement(659398..660150) Shigella dysenteriae Sd197 3799480 YP_402377.1 CDS galM NC_007606.1 660355 661395 R mutarotase; ''catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose''; aldose 1-epimerase complement(660355..661395) Shigella dysenteriae Sd197 3799481 YP_402378.1 CDS galK NC_007606.1 661389 662537 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(661389..662537) Shigella dysenteriae Sd197 3799482 YP_402379.1 CDS galT NC_007606.1 662541 663587 R catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase complement(662541..663587) Shigella dysenteriae Sd197 3799483 YP_402380.1 CDS galE NC_007606.1 663597 664613 R Code: M; COG: COG1087; UDP-galactose-4-epimerase complement(663597..664613) Shigella dysenteriae Sd197 3799484 YP_402381.1 CDS modF NC_007606.1 664875 666347 R contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF complement(664875..666347) Shigella dysenteriae Sd197 3799485 YP_402382.1 CDS modE NC_007606.1 666415 667203 R represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE complement(666415..667203) Shigella dysenteriae Sd197 3799486 YP_402383.1 CDS SDY_0709 NC_007606.1 667332 667481 D hypothetical protein 667332..667481 Shigella dysenteriae Sd197 3799487 YP_402384.1 CDS modA NC_007606.1 667648 668421 D permease; with ModCB is involved in the high-affinity transport of molybdate; molybdate ABC transporter substrate-binding protein 667648..668421 Shigella dysenteriae Sd197 3799488 YP_402385.1 CDS modB NC_007606.1 668421 669110 D part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 668421..669110 Shigella dysenteriae Sd197 3799489 YP_402386.1 CDS modC NC_007606.1 669113 670171 D Part of the ABC transporter complex modABC involved in molybdenum import; molybdate ABC transporter ATP-binding protein 669113..670171 Shigella dysenteriae Sd197 3799490 YP_402388.1 CDS SDY_0715 NC_007606.1 672580 672882 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(672580..672882) Shigella dysenteriae Sd197 3799493 YP_402389.1 CDS SDY_0716 NC_007606.1 672953 673348 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(672953..673348) Shigella dysenteriae Sd197 3799494 YP_009000658.1 CDS SDY_0718a NC_007606.1 673375 673647 R insertion element iso-IS1N protein InsA complement(673375..673647) Shigella dysenteriae Sd197 18262972 YP_402393.1 CDS SDY_0720 NC_007606.1 674813 675115 R Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN complement(674813..675115) Shigella dysenteriae Sd197 3799131 YP_402395.1 CDS SDY_0722 NC_007606.1 675741 676100 R Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN complement(675741..676100) Shigella dysenteriae Sd197 3799133 YP_402396.1 CDS SDY_0723 NC_007606.1 676139 676441 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 676139..676441 Shigella dysenteriae Sd197 3799134 YP_402397.1 CDS SDY_0724 NC_007606.1 676582 677478 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 676582..677478 Shigella dysenteriae Sd197 3799135 YP_402398.1 CDS SDY_0725 NC_007606.1 678909 679673 D bacteriophage protein 678909..679673 Shigella dysenteriae Sd197 3799136 YP_402399.1 CDS SDY_0726 NC_007606.1 679597 680415 D Code: R; COG: COG1783; bacteriophage protein 679597..680415 Shigella dysenteriae Sd197 3799137 YP_402400.1 CDS SDY_0727 NC_007606.1 680338 681171 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(680338..681171) Shigella dysenteriae Sd197 3799138 YP_402401.1 CDS SDY_0728 NC_007606.1 681312 681614 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(681312..681614) Shigella dysenteriae Sd197 3799139 YP_402402.2 CDS SDY_0729 NC_007606.1 681711 682616 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(681711..682616) Shigella dysenteriae Sd197 3799140 YP_402403.1 CDS SDY_0730 NC_007606.1 682574 682939 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(682574..682939) Shigella dysenteriae Sd197 3799141 YP_402404.1 CDS SDY_0731 NC_007606.1 683003 683404 D bacteriophage protein 683003..683404 Shigella dysenteriae Sd197 3799142 YP_402406.1 CDS SDY_0733 NC_007606.1 683625 683945 D hypothetical protein 683625..683945 Shigella dysenteriae Sd197 3799144 YP_402407.1 CDS insA NC_007606.1 683996 684271 D Code: L; COG: COG3677; insertion element IS1 protein InsA 683996..684271 Shigella dysenteriae Sd197 3799145 YP_402408.1 CDS insB NC_007606.1 684316 684693 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 684316..684693 Shigella dysenteriae Sd197 3799146 YP_402409.1 CDS rumB NC_007606.1 684954 686081 R RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase complement(684954..686081) Shigella dysenteriae Sd197 3799147 YP_402410.1 CDS ybjO NC_007606.1 686122 686610 R hypothetical protein complement(686122..686610) Shigella dysenteriae Sd197 3799148 YP_402411.1 CDS potI NC_007606.1 686671 687516 R permease; Code: E; COG: COG1177; putrescine ABC transporter membrane protein complement(686671..687516) Shigella dysenteriae Sd197 3799149 YP_402412.1 CDS potH NC_007606.1 687513 688466 R permease; Code: E; COG: COG1176; putrescine ABC transporter membrane protein complement(687513..688466) Shigella dysenteriae Sd197 3799284 YP_402413.1 CDS potG NC_007606.1 688476 689609 R part of the PotFGHI ATP-dependent putrescine transporter; putrescine ABC transporter ATP-binding protein complement(688476..689609) Shigella dysenteriae Sd197 3799285 YP_402414.1 CDS potF NC_007606.1 689704 690816 R permease; Code: E; COG: COG0687; putrescine ABC transporter substrate-binding protein complement(689704..690816) Shigella dysenteriae Sd197 3799286 YP_402415.1 CDS ybjN NC_007606.1 691167 691643 R sensory transduction regulator complement(691167..691643) Shigella dysenteriae Sd197 3799287 YP_402416.1 CDS rimK NC_007606.1 691731 692633 R responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein complement(691731..692633) Shigella dysenteriae Sd197 3799288 YP_402417.1 CDS mdaA NC_007606.1 692694 693416 R NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A complement(692694..693416) Shigella dysenteriae Sd197 3799289 YP_402418.1 CDS ybjC NC_007606.1 693400 693687 R YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein complement(693400..693687) Shigella dysenteriae Sd197 3799290 YP_402419.1 CDS grxA NC_007606.1 693847 694104 D functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 693847..694104 Shigella dysenteriae Sd197 3799291 YP_402420.1 CDS ybjM NC_007606.1 694134 694511 R hypothetical protein complement(694134..694511) Shigella dysenteriae Sd197 3799292 YP_402421.1 CDS SDY_0748 NC_007606.1 694781 696466 D Code: R; COG: COG2985; hypothetical protein 694781..696466 Shigella dysenteriae Sd197 3799293 YP_402422.1 CDS SDY_0749 NC_007606.1 696799 697350 D Code: E; COG: COG1045; hypothetical protein 696799..697350 Shigella dysenteriae Sd197 3799294 YP_402423.1 CDS SDY_0750 NC_007606.1 697410 697946 R Code: S; COG: COG3226; DeoR-type transcriptional regulator complement(697410..697946) Shigella dysenteriae Sd197 3799295 YP_402424.1 CDS SDY_0751 NC_007606.1 698030 699238 D Code: GEPR; COG: COG0477; DeoR-type transcriptional regulator 698030..699238 Shigella dysenteriae Sd197 3799296 YP_402425.1 CDS SDY_0752 NC_007606.1 699238 699498 D hypothetical protein 699238..699498 Shigella dysenteriae Sd197 3799297 YP_402426.1 CDS insB NC_007606.1 699492 699869 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(699492..699869) Shigella dysenteriae Sd197 3799298 YP_402427.1 CDS insA NC_007606.1 699914 700189 R Code: L; COG: COG3677; insertion element iso-IS1d protein InsA complement(699914..700189) Shigella dysenteriae Sd197 3799299 YP_402428.1 CDS SDY_0755 NC_007606.1 700282 701193 R Code: EP; COG: COG1173; transport system permease complement(700282..701193) Shigella dysenteriae Sd197 3799300 YP_402429.1 CDS SDY_0756 NC_007606.1 701196 702116 R Code: EP; COG: COG0601; transport system permease complement(701196..702116) Shigella dysenteriae Sd197 3799301 YP_402430.1 CDS SDY_0757 NC_007606.1 702134 703672 R Code: E; COG: COG0747; transport protein complement(702134..703672) Shigella dysenteriae Sd197 3799302 YP_402431.1 CDS SDY_0758 NC_007606.1 703692 705530 R with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione ABC transporter ATP-binding protein complement(703692..705530) Shigella dysenteriae Sd197 3799303 YP_402432.1 CDS ybiK NC_007606.1 705550 706515 R Code: E; COG: COG1446; L-asparaginase complement(705550..706515) Shigella dysenteriae Sd197 3799190 YP_402433.1 CDS moeA NC_007606.1 706719 707954 D is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 706719..707954 Shigella dysenteriae Sd197 3799191 YP_402434.1 CDS moeB NC_007606.1 707954 708703 D ''ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase''; molybdopterin biosynthesis protein MoeB 707954..708703 Shigella dysenteriae Sd197 3799192 YP_402435.2 CDS mipB NC_007606.1 708779 709441 R similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase complement(708779..709441) Shigella dysenteriae Sd197 3799193 YP_402436.1 CDS ybiY NC_007606.1 709545 710471 D Code: O; COG: COG1180; pyruvate formate-lyase 2 activating enzyme 709545..710471 Shigella dysenteriae Sd197 3799194 YP_402437.1 CDS ybiW NC_007606.1 710477 712909 D Code: C; COG: COG1882; formate acetyltransferase 710477..712909 Shigella dysenteriae Sd197 3799195 YP_402438.1 CDS SDY_0765 NC_007606.1 713055 713711 D Code: R; COG: COG0561; hypothetical protein 713055..713711 Shigella dysenteriae Sd197 3799196 YP_402439.1 CDS SDY_0766 NC_007606.1 713708 714103 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(713708..714103) Shigella dysenteriae Sd197 3799197 YP_009000659.1 CDS SDY_0767a NC_007606.1 714130 714402 R insertion element iso-IS1N protein InsA complement(714130..714402) Shigella dysenteriae Sd197 18262973 YP_402440.1 CDS SDY_0767 NC_007606.1 714683 715228 R Code: K; COG: COG1396; regulatory protein complement(714683..715228) Shigella dysenteriae Sd197 3799198 YP_402442.1 CDS SDY_0769 NC_007606.1 716050 716763 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(716050..716763) Shigella dysenteriae Sd197 3799200 YP_402443.1 CDS SDY_0770 NC_007606.1 716904 717206 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(716904..717206) Shigella dysenteriae Sd197 3799201 YP_402444.1 CDS SDY_0771 NC_007606.1 717245 717574 D hypothetical protein 717245..717574 Shigella dysenteriae Sd197 3799202 YP_402445.1 CDS SDY_0772 NC_007606.1 717561 718613 D phage tail fiber protein 717561..718613 Shigella dysenteriae Sd197 3799203 YP_402446.1 CDS SDY_0773 NC_007606.1 718914 719540 D hypothetical protein 718914..719540 Shigella dysenteriae Sd197 3799204 YP_402447.1 CDS SDY_0774 NC_007606.1 719801 720517 D DNA modification protein 719801..720517 Shigella dysenteriae Sd197 3799205 YP_402448.1 CDS ybiU NC_007606.1 720885 722144 D hypothetical protein 720885..722144 Shigella dysenteriae Sd197 3799206 YP_402449.1 CDS ybiT NC_007606.1 722385 723977 R Code: R; COG: COG0488; ATPase complement(722385..723977) Shigella dysenteriae Sd197 3799207 YP_402450.1 CDS ybiS NC_007606.1 724196 725116 D Code: S; COG: COG1376; hypothetical protein 724196..725116 Shigella dysenteriae Sd197 3799208 YP_402452.1 CDS SDY_0779 NC_007606.1 726290 726757 R Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR complement(726290..726757) Shigella dysenteriae Sd197 3797880 YP_402453.1 CDS ybiP NC_007606.1 727343 728926 D Code: R; COG: COG2194; sulfatase 727343..728926 Shigella dysenteriae Sd197 3797881 YP_402454.1 CDS ompX NC_007606.1 728975 729490 R OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X complement(728975..729490) Shigella dysenteriae Sd197 3797882 YP_402455.1 CDS dps NC_007606.1 731030 731533 D for starvation conditions; binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 731030..731533 Shigella dysenteriae Sd197 3797884 YP_402456.1 CDS insA NC_007606.1 731934 732209 R Code: L; COG: COG3677; insertion element iso-IS1d protein InsA complement(731934..732209) Shigella dysenteriae Sd197 3797885 YP_402457.1 CDS glnH NC_007606.1 732583 733329 D permease; similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter substrate-binding protein 732583..733329 Shigella dysenteriae Sd197 3797886 YP_402458.1 CDS glnP NC_007606.1 733468 734127 D similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 733468..734127 Shigella dysenteriae Sd197 3797887 YP_402459.1 CDS glnQ NC_007606.1 734124 734846 D similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 734124..734846 Shigella dysenteriae Sd197 3797888 YP_402460.1 CDS SDY_0789 NC_007606.1 736332 736727 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(736332..736727) Shigella dysenteriae Sd197 3797890 YP_009000660.1 CDS SDY_0788a NC_007606.1 736754 737026 R insertion element iso-IS1N protein InsA complement(736754..737026) Shigella dysenteriae Sd197 18262974 YP_402461.1 CDS ybiN NC_007606.1 737959 738966 R Code: R; COG: COG3129; SAM-dependent methyltransferase complement(737959..738966) Shigella dysenteriae Sd197 3797891 YP_402462.2 CDS ybiM NC_007606.1 739161 739421 D hypothetical protein 739161..739421 Shigella dysenteriae Sd197 3797892 YP_402463.1 CDS SDY_0792 NC_007606.1 739686 740018 D hypothetical protein 739686..740018 Shigella dysenteriae Sd197 3797893 YP_402464.1 CDS SDY_0793 NC_007606.1 740057 741403 D Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG 740057..741403 Shigella dysenteriae Sd197 3797894 YP_402465.1 CDS SDY_0794 NC_007606.1 741577 743406 D ''Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein''; catecholate siderophore receptor Fiu 741577..743406 Shigella dysenteriae Sd197 3797895 YP_402466.2 CDS ybiX NC_007606.1 743448 744125 D Code: S; COG: COG3128; hydroxylase 743448..744125 Shigella dysenteriae Sd197 3797896 YP_402467.1 CDS ybiI NC_007606.1 744199 744465 D Code: T; COG: COG1734; hypothetical protein 744199..744465 Shigella dysenteriae Sd197 3797897 YP_402468.1 CDS ybiJ NC_007606.1 744731 744991 D hypothetical protein 744731..744991 Shigella dysenteriae Sd197 3797898 YP_402469.1 CDS ybiC NC_007606.1 745219 746304 R Code: C; COG: COG2055; hypothetical protein complement(745219..746304) Shigella dysenteriae Sd197 3799074 YP_402470.1 CDS ybiB NC_007606.1 746445 747407 R Code: E; COG: COG0547; glycosyl transferase complement(746445..747407) Shigella dysenteriae Sd197 3799075 YP_402471.1 CDS dinG NC_007606.1 747435 749585 R helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG complement(747435..749585) Shigella dysenteriae Sd197 3799076 YP_402472.1 CDS SDY_0801 NC_007606.1 749982 750377 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(749982..750377) Shigella dysenteriae Sd197 3799077 YP_009000661.1 CDS SDY_0801a NC_007606.1 750404 750676 R insertion element iso-IS1N protein InsA complement(750404..750676) Shigella dysenteriae Sd197 18262975 YP_402474.1 CDS SDY_0803 NC_007606.1 750928 751266 D hypothetical protein 750928..751266 Shigella dysenteriae Sd197 3799079 YP_009000662.1 CDS SDY_803a NC_007606.1 751302 751574 D insertion element iso-IS1N protein InsA 751302..751574 Shigella dysenteriae Sd197 18262976 YP_402476.1 CDS SDY_0805 NC_007606.1 751601 751996 D Code: L; COG: COG1662; insertion element IS1 protein InsB 751601..751996 Shigella dysenteriae Sd197 3799081 YP_402477.1 CDS rhlE NC_007606.1 752216 753580 R this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE complement(752216..753580) Shigella dysenteriae Sd197 3799082 YP_402478.1 CDS ybiH NC_007606.1 753797 754480 D Code: K; COG: COG1309; DNA-binding transcriptional regulator 753797..754480 Shigella dysenteriae Sd197 3799083 YP_402479.1 CDS SDY_0808 NC_007606.1 754480 755478 D Code: M; COG: COG0845; hypothetical protein 754480..755478 Shigella dysenteriae Sd197 3799084 YP_402480.1 CDS ybhF NC_007606.1 755456 757207 D Code: V; COG: COG1131; ATPase 755456..757207 Shigella dysenteriae Sd197 3799085 YP_402481.1 CDS ybhS NC_007606.1 757200 758333 D Code: V; COG: COG0842; hypothetical protein 757200..758333 Shigella dysenteriae Sd197 3799086 YP_402482.1 CDS ybhR NC_007606.1 758344 759450 D Code: V; COG: COG0842; hypothetical protein 758344..759450 Shigella dysenteriae Sd197 3799087 YP_402483.1 CDS ybhQ NC_007606.1 759412 759822 R hypothetical protein complement(759412..759822) Shigella dysenteriae Sd197 3799088 YP_402484.1 CDS ybhP NC_007606.1 759955 760716 D Code: R; COG: COG3568; hypothetical protein 759955..760716 Shigella dysenteriae Sd197 3799089 YP_402485.1 CDS ybhO NC_007606.1 760713 761945 D Code: I; COG: COG1502; cardiolipin synthase 2 760713..761945 Shigella dysenteriae Sd197 3799090 YP_402486.1 CDS ybhN NC_007606.1 761945 762685 D Code: S; COG: COG0392; hypothetical protein 761945..762685 Shigella dysenteriae Sd197 3799091 YP_402487.1 CDS SDY_0816 NC_007606.1 762669 762995 R Code: L; COG: COG3677; insertion element iso-IS1N protein InsA complement(762669..762995) Shigella dysenteriae Sd197 3799092 YP_402488.1 CDS ybhL NC_007606.1 763048 763602 R Code: R; COG: COG0670; hypothetical protein complement(763048..763602) Shigella dysenteriae Sd197 3795808 YP_402489.2 CDS SDY_0818 NC_007606.1 763714 764109 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(763714..764109) Shigella dysenteriae Sd197 3795809 YP_009000663.1 CDS SDY_0819a NC_007606.1 764136 764408 R insertion element iso-IS1N protein InsA complement(764136..764408) Shigella dysenteriae Sd197 18262977 YP_402490.1 CDS SDY_0819 NC_007606.1 764468 764833 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 764468..764833 Shigella dysenteriae Sd197 3795810 YP_402491.2 CDS SDY_0820 NC_007606.1 764791 765696 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 764791..765696 Shigella dysenteriae Sd197 3795811 YP_402492.1 CDS moaE NC_007606.1 766002 766454 R catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase large subunit complement(766002..766454) Shigella dysenteriae Sd197 3795812 YP_402493.1 CDS moaD NC_007606.1 766456 766701 R catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit complement(766456..766701) Shigella dysenteriae Sd197 3795813 YP_402494.1 CDS moaC NC_007606.1 766694 767179 R MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein C complement(766694..767179) Shigella dysenteriae Sd197 3795814 YP_402495.1 CDS moaB NC_007606.1 767182 767694 R Code: H; COG: COG0521; molybdopterin biosynthesis, protein B complement(767182..767694) Shigella dysenteriae Sd197 3795815 YP_402496.1 CDS moaA NC_007606.1 767716 768705 R ''together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z''; molybdenum cofactor biosynthesis protein A complement(767716..768705) Shigella dysenteriae Sd197 3795816 YP_402497.1 CDS ybhK NC_007606.1 769102 770010 D Code: S; COG: COG0391; structural protein 769102..770010 Shigella dysenteriae Sd197 3795817 YP_402498.1 CDS uvrB NC_007606.1 770201 772222 R DNA repair; ''The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion''; excinuclease ABC subunit B complement(770201..772222) Shigella dysenteriae Sd197 3795818 YP_402499.1 CDS bioD NC_007606.1 772801 773478 R ''DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium''; dithiobiotin synthetase complement(772801..773478) Shigella dysenteriae Sd197 3795819 YP_402500.1 CDS bioC NC_007606.1 773471 774226 R reaction prior to pimeloyl CoA; ''methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth''; biotin biosynthesis protein BioC complement(773471..774226) Shigella dysenteriae Sd197 3795820 YP_402501.1 CDS bioF NC_007606.1 774213 775367 R catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase complement(774213..775367) Shigella dysenteriae Sd197 3795821 YP_402502.1 CDS bioB NC_007606.1 775364 776404 R possible sulfur insertion; Code: H; COG: COG0502; biotin synthase complement(775364..776404) Shigella dysenteriae Sd197 3795822 YP_402503.1 CDS bioA NC_007606.1 776492 777781 D ''catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate''; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 776492..777781 Shigella dysenteriae Sd197 3795823 YP_402504.1 CDS ybhB NC_007606.1 777840 778316 D YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein 777840..778316 Shigella dysenteriae Sd197 3795824 YP_402505.1 CDS ipaH_1 NC_007606.1 778896 780659 D Code: S; COG: COG4886; invasion plasmid antigen 778896..780659 Shigella dysenteriae Sd197 3795825 YP_402506.1 CDS SDY_0835 NC_007606.1 780984 781286 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 780984..781286 Shigella dysenteriae Sd197 3795826 YP_402507.1 CDS SDY_0836 NC_007606.1 781427 782140 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 781427..782140 Shigella dysenteriae Sd197 3795827 YP_402509.1 CDS yliJ NC_007606.1 782376 783008 R Code: O; COG: COG0625; transferase complement(782376..783008) Shigella dysenteriae Sd197 3799460 YP_402510.1 CDS SDY_0839 NC_007606.1 783238 783633 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(783238..783633) Shigella dysenteriae Sd197 3799461 YP_009000664.1 CDS SDY_0839a NC_007606.1 783660 783932 R insertion element iso-IS1N protein InsA complement(783660..783932) Shigella dysenteriae Sd197 18262978 YP_402512.1 CDS dacC NC_007606.1 784024 785226 D penicillin-binding protein 6; ''penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains''; D-alanyl-D-alanine carboxypeptidase 784024..785226 Shigella dysenteriae Sd197 3799463 YP_402513.1 CDS deoR NC_007606.1 785273 786031 R Code: KG; COG: COG1349; DNA-binding transcriptional repressor DeoR complement(785273..786031) Shigella dysenteriae Sd197 3799464 YP_402514.1 CDS ybjG NC_007606.1 786089 786685 R Code: I; COG: COG0671; undecaprenyl pyrophosphate phosphatase complement(786089..786685) Shigella dysenteriae Sd197 3799465 YP_402515.1 CDS SDY_0845 NC_007606.1 788515 788817 D Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 788515..788817 Shigella dysenteriae Sd197 3799467 YP_402516.1 CDS SDY_0846 NC_007606.1 788862 789683 D Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein 788862..789683 Shigella dysenteriae Sd197 3799468 YP_402517.1 CDS SDY_0847 NC_007606.1 790070 790783 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 790070..790783 Shigella dysenteriae Sd197 3799469 YP_402518.1 CDS SDY_0848 NC_007606.1 790780 791334 D hypothetical protein 790780..791334 Shigella dysenteriae Sd197 3799470 YP_402519.1 CDS SDY_0849 NC_007606.1 792549 792851 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 792549..792851 Shigella dysenteriae Sd197 3799471 YP_402520.1 CDS SDY_0850 NC_007606.1 792992 793795 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 792992..793795 Shigella dysenteriae Sd197 3799472 YP_402521.1 CDS yfaSR NC_007606.1 795138 799652 D Code: R; COG: COG2373; large extracellular alpha-helical protein 795138..799652 Shigella dysenteriae Sd197 3799474 YP_402522.1 CDS SDY_0853 NC_007606.1 799653 801302 D Code: S; COG: COG5445; hypothetical protein 799653..801302 Shigella dysenteriae Sd197 3799475 YP_402525.2 CDS rcsC NC_007606.1 802357 805206 D probable histidine kinase acting on RcsB; Code: T; COG: COG0642; hybrid sensory kinase in two-component regulatory system with RcsB and YojN 802357..805206 Shigella dysenteriae Sd197 3799652 YP_402526.1 CDS rcsB NC_007606.1 805406 806056 R sensor, RcsC; two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB complement(805406..806056) Shigella dysenteriae Sd197 3799653 YP_402527.1 CDS yojN NC_007606.1 806073 808745 R Code: T; COG: COG0642; phosphotransfer intermediate protein in two-component regulatory system with RcsBC complement(806073..808745) Shigella dysenteriae Sd197 3799654 YP_402528.1 CDS SDY_0859 NC_007606.1 809182 809577 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(809182..809577) Shigella dysenteriae Sd197 3799655 YP_009000665.1 CDS SDY_0861a NC_007606.1 809604 809876 R insertion element iso-IS1N protein InsA complement(809604..809876) Shigella dysenteriae Sd197 18262979 YP_402530.1 CDS ompC NC_007606.1 810258 811385 D Ib;c; allows for ions and hydrophilic solutes to cross the outer membrane; porin 810258..811385 Shigella dysenteriae Sd197 3799657 YP_402531.1 CDS yojL NC_007606.1 811497 812552 D catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 811497..812552 Shigella dysenteriae Sd197 3799658 YP_402532.1 CDS ada NC_007606.1 812626 813690 D transcription activator/repressor; Code: F; COG: COG2169; O6-methylguanine-DNA methyltransferase 812626..813690 Shigella dysenteriae Sd197 3799659 YP_402533.1 CDS alkB NC_007606.1 813690 814340 D Code: L; COG: COG3145; DNA repair system specific for alkylated DNA 813690..814340 Shigella dysenteriae Sd197 3799660 YP_402534.1 CDS yojI NC_007606.1 814416 816059 D efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane protein/ATP-binding protein 814416..816059 Shigella dysenteriae Sd197 3799661 YP_402535.1 CDS yojH NC_007606.1 816277 817923 D malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 816277..817923 Shigella dysenteriae Sd197 3799662 YP_402536.1 CDS SDY_0867 NC_007606.1 818619 819395 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(818619..819395) Shigella dysenteriae Sd197 3799663 YP_402537.1 CDS SDY_0868 NC_007606.1 819536 819838 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(819536..819838) Shigella dysenteriae Sd197 3799664 YP_402538.1 CDS napF NC_007606.1 820463 820957 D electron transfer; Predicted role in electron transfer to the periplasmic nitrate reductase NapA; ferredoxin-type protein 820463..820957 Shigella dysenteriae Sd197 3799666 YP_402539.1 CDS napD NC_007606.1 820947 821210 D Code: P; COG: COG3062; assembly protein for periplasmic nitrate reductase 820947..821210 Shigella dysenteriae Sd197 3799667 YP_402540.1 CDS napA NC_007606.1 821207 823693 D periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 821207..823693 Shigella dysenteriae Sd197 3799668 YP_402541.1 CDS napG NC_007606.1 823700 824395 D electron transfer; part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic subunit 823700..824395 Shigella dysenteriae Sd197 3799669 YP_402542.1 CDS napH NC_007606.1 824382 825245 D electron transfer; part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane subunit 824382..825245 Shigella dysenteriae Sd197 3799670 YP_402543.2 CDS napB NC_007606.1 825242 825691 D small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 825242..825691 Shigella dysenteriae Sd197 3799671 YP_402544.1 CDS napC NC_007606.1 825701 826303 D with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 825701..826303 Shigella dysenteriae Sd197 3796881 YP_402545.1 CDS ccmA NC_007606.1 826322 826939 D ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 826322..826939 Shigella dysenteriae Sd197 3796882 YP_402546.1 CDS ccmB NC_007606.1 826936 827598 D cytochrome c-type biogenesis protein; Code: O; COG: COG2386; heme exporter protein B 826936..827598 Shigella dysenteriae Sd197 3796883 YP_402547.1 CDS ccmC NC_007606.1 827640 828377 D Code: O; COG: COG0755; heme exporter protein C 827640..828377 Shigella dysenteriae Sd197 3796884 YP_402548.1 CDS ccmD NC_007606.1 828374 828583 D Code: U; COG: COG3114; heme exporter protein C 828374..828583 Shigella dysenteriae Sd197 3796885 YP_402549.1 CDS ccmE NC_007606.1 828580 829059 D possible subunit of a heme lyase; CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 828580..829059 Shigella dysenteriae Sd197 3796886 YP_402550.1 CDS ccmF NC_007606.1 829056 830999 D Code: O; COG: COG1138; cytochrome c-type biogenesis protein 829056..830999 Shigella dysenteriae Sd197 3796887 YP_402551.1 CDS dsbE NC_007606.1 830996 831553 D possibly involved in biogenesis of cytochrome c; Code: OC; COG: COG0526; disulfide oxidoreductase 830996..831553 Shigella dysenteriae Sd197 3796888 YP_402552.1 CDS ccmH NC_007606.1 831550 832602 D Code: O; COG: COG4235; subunit of heme lyase 831550..832602 Shigella dysenteriae Sd197 3796889 YP_402553.1 CDS narP NC_007606.1 832813 833460 R sensor NarQ; nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP complement(832813..833460) Shigella dysenteriae Sd197 3796890 YP_402554.1 CDS SDY_0886 NC_007606.1 834089 834484 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(834089..834484) Shigella dysenteriae Sd197 3796891 YP_009000666.1 CDS SDY_0886a NC_007606.1 834511 834783 R insertion element iso-IS1N protein InsA complement(834511..834783) Shigella dysenteriae Sd197 18262980 YP_402556.1 CDS insA NC_007606.1 835389 835664 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(835389..835664) Shigella dysenteriae Sd197 3796893 YP_402557.1 CDS yejO NC_007606.1 835867 837921 D Code: MU; COG: COG3468; ATPase 835867..837921 Shigella dysenteriae Sd197 3796894 YP_402558.1 CDS yejM NC_007606.1 838174 839934 R Code: R; COG: COG3083; sulfatase complement(838174..839934) Shigella dysenteriae Sd197 3796896 YP_402559.1 CDS yejL NC_007606.1 839954 840181 R Code: S; COG: COG3082; hypothetical protein complement(839954..840181) Shigella dysenteriae Sd197 3796897 YP_402560.1 CDS yejK NC_007606.1 840363 841370 D Code: R; COG: COG3081; nucleoid-associated protein NdpA 840363..841370 Shigella dysenteriae Sd197 3796898 YP_402561.1 CDS rplY NC_007606.1 841509 841793 R ''the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response''; 50S ribosomal protein L25 complement(841509..841793) Shigella dysenteriae Sd197 3799304 YP_402562.1 CDS yejH NC_007606.1 841918 843678 R Code: KL; COG: COG1061; ATP-dependent helicase complement(841918..843678) Shigella dysenteriae Sd197 3799305 YP_402563.1 CDS rsuA NC_007606.1 843828 844523 D catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 843828..844523 Shigella dysenteriae Sd197 3799306 YP_402564.1 CDS bcr NC_007606.1 844551 845741 D transmembrane protein; Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system protein 844551..845741 Shigella dysenteriae Sd197 3799307 YP_402565.1 CDS yejG NC_007606.1 846074 846418 D hypothetical protein 846074..846418 Shigella dysenteriae Sd197 3799308 YP_402566.1 CDS yejF NC_007606.1 846422 848011 R Code: R; COG: COG4172; ATPase complement(846422..848011) Shigella dysenteriae Sd197 3799309 YP_402567.1 CDS yejE NC_007606.1 848013 849038 R Code: R; COG: COG4239; transport system permease complement(848013..849038) Shigella dysenteriae Sd197 3799310 YP_402568.1 CDS yejB NC_007606.1 849038 850132 R Code: R; COG: COG4174; transport system permease complement(849038..850132) Shigella dysenteriae Sd197 3799311 YP_402569.2 CDS yejA NC_007606.1 850133 851947 R Code: E; COG: COG4166; hypothetical protein complement(850133..851947) Shigella dysenteriae Sd197 3799312 YP_402570.1 CDS rtn NC_007606.1 852029 853585 R Code: T; COG: COG2200; hypothetical protein complement(852029..853585) Shigella dysenteriae Sd197 3799313 YP_402571.1 CDS spr NC_007606.1 853766 854332 R ''by similarity, Spr seems to have peptidase activity; involved in thermoresistance''; outer membrane lipoprotein complement(853766..854332) Shigella dysenteriae Sd197 3799314 YP_402572.1 CDS SDY_0905 NC_007606.1 854744 855493 R Code: I; COG: COG0671; hypothetical protein complement(854744..855493) Shigella dysenteriae Sd197 3799315 YP_402573.1 CDS yeiR NC_007606.1 855496 856482 R Code: R; COG: COG0523; hypothetical protein complement(855496..856482) Shigella dysenteriae Sd197 3799316 YP_402575.2 CDS yeiP NC_007606.1 858289 858861 R ''Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein''; elongation factor P complement(858289..858861) Shigella dysenteriae Sd197 3799318 YP_009000667.1 CDS SDY_0907a NC_007606.1 859016 859270 D hypothetical protein 859016..859270 Shigella dysenteriae Sd197 18262981 YP_402576.1 CDS yeiO NC_007606.1 859267 860448 R Code: GEPR; COG: COG0477; transporter complement(859267..860448) Shigella dysenteriae Sd197 3799319 YP_402577.1 CDS SDY_0910 NC_007606.1 860588 860803 R insertion element iso-IS1n protein InsB complement(860588..860803) Shigella dysenteriae Sd197 3799320 YP_009000668.1 CDS SDY_0912a NC_007606.1 861009 861281 R insertion element iso-IS1N protein InsA complement(861009..861281) Shigella dysenteriae Sd197 18262982 YP_402579.1 CDS SDY_0912 NC_007606.1 861552 862385 D hypothetical protein 861552..862385 Shigella dysenteriae Sd197 3799322 YP_009000669.1 CDS SDY_0913a NC_007606.1 862481 862753 D insertion element iso-IS1N protein InsA 862481..862753 Shigella dysenteriae Sd197 18262983 YP_402580.1 CDS SDY_0913 NC_007606.1 862959 863174 D insertion element iso-IS1n protein InsB 862959..863174 Shigella dysenteriae Sd197 3799323 YP_402581.1 CDS SDY_0914 NC_007606.1 863152 864219 D Code: NU; COG: COG3539; FimH-like protein 863152..864219 Shigella dysenteriae Sd197 3799615 YP_402582.1 CDS SDY_0915 NC_007606.1 864263 864772 D Code: NU; COG: COG3539; fimbrial-like protein 864263..864772 Shigella dysenteriae Sd197 3799616 YP_402583.1 CDS SDY_0916 NC_007606.1 864732 865295 D Code: NU; COG: COG3539; fimbrial-like protein 864732..865295 Shigella dysenteriae Sd197 3799617 YP_402584.1 CDS ycbF NC_007606.1 865261 865998 D Code: NU; COG: COG3121; pili assembly chaperone 865261..865998 Shigella dysenteriae Sd197 3799618 YP_402585.1 CDS pyrD NC_007606.1 866109 867119 D ''catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors''; dihydroorotate dehydrogenase 2 866109..867119 Shigella dysenteriae Sd197 3799619 YP_402586.1 CDS ycbW NC_007606.1 867257 867835 D hypothetical protein 867257..867835 Shigella dysenteriae Sd197 3799620 YP_402587.1 CDS SDY_0920 NC_007606.1 867832 868941 R Code: R; COG: COG3217; hypothetical protein complement(867832..868941) Shigella dysenteriae Sd197 3799621 YP_402588.1 CDS rlmL NC_007606.1 869185 871293 D catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 869185..871293 Shigella dysenteriae Sd197 3799622 YP_402589.1 CDS uup NC_007606.1 871305 873212 D Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 871305..873212 Shigella dysenteriae Sd197 3799623 YP_402590.1 CDS pqiA NC_007606.1 873342 874595 D Code: S; COG: COG2995; paraquat-inducible protein A 873342..874595 Shigella dysenteriae Sd197 3799624 YP_402591.1 CDS pqiB NC_007606.1 874600 876240 D Code: R; COG: COG3008; paraquat-inducible protein B 874600..876240 Shigella dysenteriae Sd197 3799625 YP_402592.1 CDS ymbA NC_007606.1 876252 876800 D Code: S; COG: COG3009; hypothetical protein 876252..876800 Shigella dysenteriae Sd197 3799626 YP_402593.1 CDS rmf NC_007606.1 877056 877223 D Code: J; COG: COG3130; ribosome modulation factor 877056..877223 Shigella dysenteriae Sd197 3799627 YP_402594.1 CDS fabA NC_007606.1 877293 877811 R trans-2-decenoyl-ACP isomerase; ''catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP''; 3-hydroxydecanoyl-ACP dehydratase complement(877293..877811) Shigella dysenteriae Sd197 3799628 YP_402595.1 CDS ycbG NC_007606.1 879851 880303 D Code: S; COG: COG3120; hypothetical protein 879851..880303 Shigella dysenteriae Sd197 3799630 YP_402596.1 CDS ompA NC_007606.1 880379 881431 R II*;G;d; ''OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d''; outer membrane protein OmpA complement(880379..881431) Shigella dysenteriae Sd197 3799631 YP_402597.1 CDS SDY_0931 NC_007606.1 882087 882389 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 882087..882389 Shigella dysenteriae Sd197 3799632 YP_402598.1 CDS SDY_0932 NC_007606.1 882530 883315 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 882530..883315 Shigella dysenteriae Sd197 3799633 YP_402599.1 CDS SDY_0934 NC_007606.1 883786 884415 D Code: K; COG: COG3070; hypothetical protein 883786..884415 Shigella dysenteriae Sd197 3798487 YP_402600.1 CDS SDY_0935 NC_007606.1 884378 886540 R Code: S; COG: COG1289; hypothetical protein complement(884378..886540) Shigella dysenteriae Sd197 3798488 YP_402601.1 CDS yccF NC_007606.1 886550 886996 R Code: S; COG: COG3304; hypothetical protein complement(886550..886996) Shigella dysenteriae Sd197 3798489 YP_402602.1 CDS helD NC_007606.1 887119 889173 D catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 887119..889173 Shigella dysenteriae Sd197 3798490 YP_402603.2 CDS mgsA NC_007606.1 889205 889663 R catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase complement(889205..889663) Shigella dysenteriae Sd197 3798491 YP_402604.1 CDS SDY_0939 NC_007606.1 889759 890421 R Code: S; COG: COG3110; hypothetical protein complement(889759..890421) Shigella dysenteriae Sd197 3798492 YP_402605.1 CDS SDY_0940 NC_007606.1 890513 891007 D Code: R; COG: COG1832; hypothetical protein 890513..891007 Shigella dysenteriae Sd197 3798493 YP_402606.1 CDS yccV NC_007606.1 891052 891420 R Code: S; COG: COG3785; hypothetical protein complement(891052..891420) Shigella dysenteriae Sd197 3798494 YP_402607.1 CDS yccW NC_007606.1 891427 892623 R Code: R; COG: COG1092; hypothetical protein complement(891427..892623) Shigella dysenteriae Sd197 3798495 YP_402608.1 CDS SDY_0943 NC_007606.1 892718 892996 D Code: C; COG: COG1254; hypothetical protein 892718..892996 Shigella dysenteriae Sd197 3798496 YP_402609.2 CDS yccK NC_007606.1 892993 893322 R transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE complement(892993..893322) Shigella dysenteriae Sd197 3798497 YP_402610.1 CDS yccA NC_007606.1 893413 894072 R Code: R; COG: COG0670; hypothetical protein complement(893413..894072) Shigella dysenteriae Sd197 3798498 YP_402611.1 CDS hyaA NC_007606.1 894797 895915 D Code: C; COG: COG1740; hydrogenase-1 small subunit 894797..895915 Shigella dysenteriae Sd197 3798500 YP_402613.1 CDS hyaC NC_007606.1 897710 898417 D Code: C; COG: COG1969; hydrogenase 1 b-type cytochrome subunit 897710..898417 Shigella dysenteriae Sd197 3798502 YP_402614.1 CDS hyaD NC_007606.1 898414 899001 D HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 898414..899001 Shigella dysenteriae Sd197 3798503 YP_402615.1 CDS hyaE NC_007606.1 898998 899396 D involved in processing hydrogenases HyaA and HyaB; hydrogenase-1 operon protein HyaE 898998..899396 Shigella dysenteriae Sd197 3798504 YP_402616.1 CDS appC NC_007606.1 900384 901928 D Code: C; COG: COG1271; cytochrome bd-II oxidase subunit I 900384..901928 Shigella dysenteriae Sd197 3798729 YP_402617.1 CDS appB NC_007606.1 901940 903076 D Code: C; COG: COG1294; cytochrome bd-II oxidase subunit II 901940..903076 Shigella dysenteriae Sd197 3798730 YP_402618.1 CDS yccB NC_007606.1 903089 903181 D Code: S; COG: COG4890; hypothetical protein 903089..903181 Shigella dysenteriae Sd197 3798731 YP_402619.1 CDS appA NC_007606.1 903261 904565 D pH 2.5 acid phosphatase; periplasmic; phosphoanhydride phosphorylase 903261..904565 Shigella dysenteriae Sd197 3798732 YP_402620.1 CDS yccC NC_007606.1 904685 906865 R Code: M; COG: COG3206; cryptic autophosphorylating protein tyrosine kinase Etk complement(904685..906865) Shigella dysenteriae Sd197 3798733 YP_402621.2 CDS etp NC_007606.1 906885 907331 R ''Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk''; phosphotyrosine-protein phosphatase complement(906885..907331) Shigella dysenteriae Sd197 3798734 YP_402622.1 CDS yccZ NC_007606.1 907319 908458 R Code: M; COG: COG1596; function in exopolysaccharide production complement(907319..908458) Shigella dysenteriae Sd197 3798735 YP_402623.1 CDS ymcA NC_007606.1 908504 910600 R hypothetical protein complement(908504..910600) Shigella dysenteriae Sd197 3798736 YP_402624.1 CDS ymcB NC_007606.1 910600 911346 R hypothetical protein complement(910600..911346) Shigella dysenteriae Sd197 3798737 YP_402625.1 CDS ymcC NC_007606.1 911343 911987 R regulator complement(911343..911987) Shigella dysenteriae Sd197 3798738 YP_402626.1 CDS ymcD NC_007606.1 912094 912417 R hypothetical protein complement(912094..912417) Shigella dysenteriae Sd197 3798739 YP_402627.1 CDS cspH NC_007606.1 912841 913053 R Code: K; COG: COG1278; cold shock-like protein complement(912841..913053) Shigella dysenteriae Sd197 3798740 YP_402628.1 CDS SDY_0965 NC_007606.1 913330 913725 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(913330..913725) Shigella dysenteriae Sd197 3798741 YP_009000670.1 CDS SDY_0965a NC_007606.1 913752 914024 R insertion element iso-IS1N protein InsA complement(913752..914024) Shigella dysenteriae Sd197 18262984 YP_402629.1 CDS yccM NC_007606.1 914060 914620 R Code: C; COG: COG0348; hypothetical protein complement(914060..914620) Shigella dysenteriae Sd197 3798742 YP_402630.1 CDS torT NC_007606.1 917512 918540 D part of regulation of tor operon, periplasmic; periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 917512..918540 Shigella dysenteriae Sd197 3798744 YP_402631.1 CDS torR NC_007606.1 918513 919205 R sensor TorS; response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR complement(918513..919205) Shigella dysenteriae Sd197 3798745 YP_402632.1 CDS torD NC_007606.1 922989 923588 D ''TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor''; chaperone protein TorD 922989..923588 Shigella dysenteriae Sd197 3797068 YP_402633.1 CDS yccD NC_007606.1 923740 924045 R with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM complement(923740..924045) Shigella dysenteriae Sd197 3797069 YP_402634.1 CDS cbpA NC_007606.1 924045 924965 R functions closely related to DnaJ; ''functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock''; curved DNA-binding protein CbpA complement(924045..924965) Shigella dysenteriae Sd197 3797070 YP_009000671.1 CDS SDY_0974a NC_007606.1 925232 925504 D insertion element iso-IS1N protein InsA 925232..925504 Shigella dysenteriae Sd197 18262985 YP_009000672.1 CDS SDY_0975 NC_007606.1 925531 925815 D hypothetical protein 925531..925815 Shigella dysenteriae Sd197 3797071 YP_402636.1 CDS insB NC_007606.1 925809 926186 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(925809..926186) Shigella dysenteriae Sd197 3797072 YP_402638.1 CDS agp NC_007606.1 927854 929095 D glucose-1-phosphatase/inositol phosphatase 927854..929095 Shigella dysenteriae Sd197 3797074 YP_402639.1 CDS yccJ NC_007606.1 929133 929360 R hypothetical protein complement(929133..929360) Shigella dysenteriae Sd197 3797075 YP_402640.1 CDS wrbA NC_007606.1 929381 929977 R affects association of trp repressor and operator; stationary phase that binds TrpR repressor; TrpR binding protein WrbA complement(929381..929977) Shigella dysenteriae Sd197 3797076 YP_009000673.1 CDS SDY_0980a NC_007606.1 930350 930523 D hypothetical protein 930350..930523 Shigella dysenteriae Sd197 18262986 YP_402641.1 CDS ycdG NC_007606.1 930606 932000 R Code: F; COG: COG2233; transport protein complement(930606..932000) Shigella dysenteriae Sd197 3797077 YP_402642.1 CDS SDY_0982 NC_007606.1 931955 932413 R Code: R; COG: COG1853; hypothetical protein complement(931955..932413) Shigella dysenteriae Sd197 3797078 YP_402643.1 CDS SDY_0983 NC_007606.1 932460 933050 R Code: C; COG: COG0778; hypothetical protein complement(932460..933050) Shigella dysenteriae Sd197 3797079 YP_402644.1 CDS SDY_0984 NC_007606.1 933060 933734 R Code: R; COG: COG0596; acetyltransferase complement(933060..933734) Shigella dysenteriae Sd197 3797080 YP_402645.1 CDS SDY_0985 NC_007606.1 933742 934128 R Code: J; COG: COG0251; hypothetical protein complement(933742..934128) Shigella dysenteriae Sd197 3797081 YP_402646.1 CDS SDY_0987 NC_007606.1 934832 935980 R Code: C; COG: COG2141; hypothetical protein complement(934832..935980) Shigella dysenteriae Sd197 3797083 YP_402647.1 CDS ycdC NC_007606.1 936212 936850 D Code: K; COG: COG1309; tet operon regulator 936212..936850 Shigella dysenteriae Sd197 3797084 YP_402648.1 CDS putP NC_007606.1 941275 942783 D Code: ER; COG: COG0591; major sodium/proline symporter 941275..942783 Shigella dysenteriae Sd197 3797125 YP_402651.1 CDS insA NC_007606.1 944740 945015 D Code: L; COG: COG3677; insertion element IS1 protein InsA 944740..945015 Shigella dysenteriae Sd197 3797128 YP_402652.1 CDS insB NC_007606.1 945060 945437 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 945060..945437 Shigella dysenteriae Sd197 3797129 YP_009000674.1 CDS SDY_0995a NC_007606.1 945759 946031 R insertion element iso-IS1N protein InsA complement(945759..946031) Shigella dysenteriae Sd197 18262987 YP_402654.1 CDS csgE NC_007606.1 946490 946879 D 2nd curli operon; chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 946490..946879 Shigella dysenteriae Sd197 3797132 YP_402655.1 CDS csgF NC_007606.1 946904 947320 D 2nd curli operon; nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 946904..947320 Shigella dysenteriae Sd197 3797133 YP_402656.1 CDS csgG NC_007606.1 947347 948180 D 2nd curli operon; Code: M; COG: COG1462; curli production assembly/transport protein 947347..948180 Shigella dysenteriae Sd197 3797134 YP_009000675.1 CDS SDY_0999a NC_007606.1 948272 948544 D insertion element iso-IS1N protein InsA 948272..948544 Shigella dysenteriae Sd197 18262988 YP_402657.1 CDS SDY_1000 NC_007606.1 948571 948966 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 948571..948966 Shigella dysenteriae Sd197 3797135 YP_402658.1 CDS ycdZ NC_007606.1 949018 949557 R hypothetical protein complement(949018..949557) Shigella dysenteriae Sd197 3797136 YP_402659.1 CDS ycdY NC_007606.1 949611 950165 R Code: R; COG: COG3381; oxidoreductase complement(949611..950165) Shigella dysenteriae Sd197 3797137 YP_402660.1 CDS ycdX NC_007606.1 950189 950926 R Code: ER; COG: COG1387; hydrolase complement(950189..950926) Shigella dysenteriae Sd197 3797138 YP_402661.1 CDS ycdW NC_007606.1 950981 951958 R Code: HE; COG: COG0111; dehydrogenase complement(950981..951958) Shigella dysenteriae Sd197 3797139 YP_402662.1 CDS SDY_1006 NC_007606.1 952390 953232 R hypothetical protein complement(952390..953232) Shigella dysenteriae Sd197 3797141 YP_402663.1 CDS SDY_1007 NC_007606.1 953329 953526 R hypothetical protein complement(953329..953526) Shigella dysenteriae Sd197 3797142 YP_402664.1 CDS SDY_1008 NC_007606.1 953538 954029 R hypothetical protein complement(953538..954029) Shigella dysenteriae Sd197 3797163 YP_402665.1 CDS yeeV NC_007606.1 954026 954400 R hypothetical protein complement(954026..954400) Shigella dysenteriae Sd197 3797164 YP_402666.1 CDS yeeU NC_007606.1 954447 954824 R structural protein complement(954447..954824) Shigella dysenteriae Sd197 3797165 YP_402667.1 CDS SDY_1011 NC_007606.1 954874 955518 R hypothetical protein complement(954874..955518) Shigella dysenteriae Sd197 3797166 YP_402668.1 CDS yeeT NC_007606.1 955537 955758 R hypothetical protein complement(955537..955758) Shigella dysenteriae Sd197 3797167 YP_402669.1 CDS SDY_1013 NC_007606.1 955827 956279 R Code: L; COG: COG2003; radC-like protein YeeS complement(955827..956279) Shigella dysenteriae Sd197 3797168 YP_402670.1 CDS SDY_1014 NC_007606.1 956295 956840 R hypothetical protein complement(956295..956840) Shigella dysenteriae Sd197 3797169 YP_402671.1 CDS SDY_1015 NC_007606.1 957048 957869 R hypothetical protein complement(957048..957869) Shigella dysenteriae Sd197 3797170 YP_402672.1 CDS SDY_1016 NC_007606.1 958263 958526 R hypothetical protein complement(958263..958526) Shigella dysenteriae Sd197 3797171 YP_402673.1 CDS SDY_1017 NC_007606.1 959177 959644 R hypothetical protein complement(959177..959644) Shigella dysenteriae Sd197 3797172 YP_402674.1 CDS SDY_1018 NC_007606.1 960581 961423 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 960581..961423 Shigella dysenteriae Sd197 3797173 YP_402675.2 CDS SDY_1019 NC_007606.1 961257 962162 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(961257..962162) Shigella dysenteriae Sd197 3797174 YP_402676.1 CDS SDY_1020 NC_007606.1 962120 962485 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(962120..962485) Shigella dysenteriae Sd197 3797175 YP_402677.1 CDS SDY_1021 NC_007606.1 963197 963592 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(963197..963592) Shigella dysenteriae Sd197 3797176 YP_009000676.1 CDS SDY_1021a NC_007606.1 963619 963891 R insertion element iso-IS1N protein InsA complement(963619..963891) Shigella dysenteriae Sd197 18262989 YP_402678.1 CDS iroN NC_007606.1 963985 966162 D Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 963985..966162 Shigella dysenteriae Sd197 3797177 YP_402679.1 CDS iroE NC_007606.1 966207 967163 R Code: R; COG: COG2819; hypothetical protein complement(966207..967163) Shigella dysenteriae Sd197 3797178 YP_402680.1 CDS iroD NC_007606.1 967248 968477 R Code: P; COG: COG2382; ferric enterochelin esterase complement(967248..968477) Shigella dysenteriae Sd197 3797179 YP_402681.1 CDS iroC NC_007606.1 968581 972240 R Code: V; COG: COG1132; ABC transporter protein complement(968581..972240) Shigella dysenteriae Sd197 3797180 YP_402682.1 CDS iroB NC_007606.1 972380 973495 R Code: GC; COG: COG1819; glycosyl transferase complement(972380..973495) Shigella dysenteriae Sd197 3797181 YP_402686.1 CDS SDY_1030 NC_007606.1 975122 975424 R Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN complement(975122..975424) Shigella dysenteriae Sd197 3796806 YP_402687.1 CDS SDY_1031 NC_007606.1 976057 976452 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(976057..976452) Shigella dysenteriae Sd197 3796807 YP_009000677.1 CDS SDY_1031a NC_007606.1 976479 976751 R insertion element iso-IS1N protein InsA complement(976479..976751) Shigella dysenteriae Sd197 18262990 YP_402689.1 CDS SDY_1033 NC_007606.1 977103 977753 R Code: R; COG: COG3443; hypothetical protein complement(977103..977753) Shigella dysenteriae Sd197 3796809 YP_402690.1 CDS SDY_1034 NC_007606.1 978010 978645 R in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ complement(978010..978645) Shigella dysenteriae Sd197 3796810 YP_402691.1 CDS SDY_1035 NC_007606.1 978646 979650 R in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY complement(978646..979650) Shigella dysenteriae Sd197 3796811 YP_402692.1 CDS SDY_1036 NC_007606.1 979876 980271 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(979876..980271) Shigella dysenteriae Sd197 3796812 YP_009000678.1 CDS SDY_1038a NC_007606.1 980298 980570 R insertion element iso-IS1N protein InsA complement(980298..980570) Shigella dysenteriae Sd197 18262991 YP_402694.1 CDS SDY_1038 NC_007606.1 980610 980936 R Code: R; COG: COG2351; hypothetical protein complement(980610..980936) Shigella dysenteriae Sd197 3796814 YP_402695.2 CDS yedW NC_007606.1 981069 981719 D induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulator YedW 981069..981719 Shigella dysenteriae Sd197 3796815 YP_402696.1 CDS SDY_1040 NC_007606.1 981694 982089 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(981694..982089) Shigella dysenteriae Sd197 3796816 YP_009000679.1 CDS SDY_1042a NC_007606.1 982116 982388 R insertion element iso-IS1N protein InsA complement(982116..982388) Shigella dysenteriae Sd197 18262992 YP_402698.1 CDS SDY_1042 NC_007606.1 982511 982894 D hypothetical protein 982511..982894 Shigella dysenteriae Sd197 3796818 YP_402701.1 CDS dcm NC_007606.1 983685 985103 D Code: L; COG: COG0270; DNA cytosine methylase 983685..985103 Shigella dysenteriae Sd197 3796821 YP_402702.1 CDS vsr NC_007606.1 985084 985554 D Code: L; COG: COG3727; DNA mismatch endonuclease 985084..985554 Shigella dysenteriae Sd197 3796822 YP_402703.1 CDS yedA NC_007606.1 985543 986463 R Code: GER; COG: COG0697; hypothetical protein complement(985543..986463) Shigella dysenteriae Sd197 3796728 YP_402704.1 CDS yedI NC_007606.1 986636 987553 D Code: S; COG: COG2354; hypothetical protein 986636..987553 Shigella dysenteriae Sd197 3796729 YP_402705.1 CDS SDY_1049 NC_007606.1 987632 987814 D Code: S; COG: COG5475; hypothetical protein 987632..987814 Shigella dysenteriae Sd197 3796730 YP_402706.1 CDS SDY_1050 NC_007606.1 988003 989679 D Code: T; COG: COG2199; hypothetical protein 988003..989679 Shigella dysenteriae Sd197 3796731 YP_402707.1 CDS SDY_1051 NC_007606.1 989676 990491 R catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase complement(989676..990491) Shigella dysenteriae Sd197 3796732 YP_402708.1 CDS SDY_1052 NC_007606.1 990789 991031 R hypothetical protein complement(990789..991031) Shigella dysenteriae Sd197 3796733 YP_402709.1 CDS dsrB NC_007606.1 991165 991353 D hypothetical protein 991165..991353 Shigella dysenteriae Sd197 3796734 YP_009000680.1 CDS SDY_1053a NC_007606.1 991693 991965 D insertion element iso-IS1N protein InsA 991693..991965 Shigella dysenteriae Sd197 18262993 YP_402710.1 CDS SDY_1054 NC_007606.1 991992 992387 D Code: L; COG: COG1662; insertion element IS1 protein InsB 991992..992387 Shigella dysenteriae Sd197 3796735 YP_402711.1 CDS insB NC_007606.1 992462 992839 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(992462..992839) Shigella dysenteriae Sd197 3796736 YP_402712.1 CDS insA NC_007606.1 992884 993159 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(992884..993159) Shigella dysenteriae Sd197 3796737 YP_402713.1 CDS SDY_1057 NC_007606.1 993493 993888 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(993493..993888) Shigella dysenteriae Sd197 3796738 YP_009000681.1 CDS SDY_1057a NC_007606.1 993915 994187 R insertion element iso-IS1N protein InsA complement(993915..994187) Shigella dysenteriae Sd197 18262994 YP_402716.2 CDS SDY_1060 NC_007606.1 996113 996769 D Code: QR; COG: COG0500; hypothetical protein 996113..996769 Shigella dysenteriae Sd197 3796741 YP_009000682.1 CDS SDY_1061a NC_007606.1 997133 997405 D insertion element iso-IS1N protein InsA 997133..997405 Shigella dysenteriae Sd197 18262995 YP_402717.1 CDS SDY_1061 NC_007606.1 997432 997827 D Code: L; COG: COG1662; insertion element IS1 protein InsB 997432..997827 Shigella dysenteriae Sd197 3796742 YP_402719.1 CDS SDY_1063 NC_007606.1 999324 1000109 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(999324..1000109) Shigella dysenteriae Sd197 3796744 YP_402720.1 CDS SDY_1064 NC_007606.1 1000250 1000552 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(1000250..1000552) Shigella dysenteriae Sd197 3796745 YP_402721.1 CDS SDY_1065 NC_007606.1 1001080 1002129 R tail fiber protein complement(1001080..1002129) Shigella dysenteriae Sd197 3796746 YP_402722.1 CDS SDY_1066 NC_007606.1 1002153 1002641 R tail fiber assembly protein complement(1002153..1002641) Shigella dysenteriae Sd197 3796747 YP_402723.1 CDS SDY_1067 NC_007606.1 1002701 1002814 R phage tail fiber protein complement(1002701..1002814) Shigella dysenteriae Sd197 3799923 YP_402724.1 CDS SDY_1068 NC_007606.1 1002853 1003155 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1002853..1003155 Shigella dysenteriae Sd197 3799924 YP_402725.1 CDS SDY_1069 NC_007606.1 1003296 1004009 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 1003296..1004009 Shigella dysenteriae Sd197 3799925 YP_402726.1 CDS SDY_1070 NC_007606.1 1004265 1004660 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1004265..1004660) Shigella dysenteriae Sd197 3799926 YP_009000683.1 CDS SDY_1069a NC_007606.1 1004687 1004959 R insertion element iso-IS1N protein InsA complement(1004687..1004959) Shigella dysenteriae Sd197 18262996 YP_402727.1 CDS SDY_1072 NC_007606.1 1005276 1006112 D Code: S; COG: COG3228; hypothetical protein 1005276..1006112 Shigella dysenteriae Sd197 3799928 YP_402728.1 CDS SDY_1074 NC_007606.1 1006574 1006978 D hypothetical protein 1006574..1006978 Shigella dysenteriae Sd197 3799930 YP_402729.1 CDS SDY_1075 NC_007606.1 1007089 1007865 D hypothetical protein 1007089..1007865 Shigella dysenteriae Sd197 3799931 YP_402730.1 CDS SDY_1076 NC_007606.1 1007889 1008107 D hypothetical protein 1007889..1008107 Shigella dysenteriae Sd197 3799932 YP_402731.1 CDS SDY_1077 NC_007606.1 1008318 1008851 D hypothetical protein 1008318..1008851 Shigella dysenteriae Sd197 3799933 YP_402732.2 CDS SDY_1078 NC_007606.1 1008822 1009727 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(1008822..1009727) Shigella dysenteriae Sd197 3799934 YP_402733.1 CDS SDY_1079 NC_007606.1 1009685 1010050 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(1009685..1010050) Shigella dysenteriae Sd197 3799935 YP_402735.1 CDS SDY_1081 NC_007606.1 1011244 1011639 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1011244..1011639) Shigella dysenteriae Sd197 3799937 YP_009000684.1 CDS SDY_1083a NC_007606.1 1011666 1011938 R insertion element iso-IS1N protein InsA complement(1011666..1011938) Shigella dysenteriae Sd197 18262997 YP_402737.1 CDS SDY_1083 NC_007606.1 1012083 1012478 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1012083..1012478) Shigella dysenteriae Sd197 3799939 YP_009000685.1 CDS SDY_1084a NC_007606.1 1012505 1012777 R insertion element iso-IS1N protein InsA complement(1012505..1012777) Shigella dysenteriae Sd197 18262998 YP_402738.1 CDS yedK NC_007606.1 1012902 1013573 R Code: S; COG: COG2135; hypothetical protein complement(1012902..1013573) Shigella dysenteriae Sd197 3797826 YP_402739.1 CDS yedF NC_007606.1 1013682 1013915 R Code: O; COG: COG0425; hypothetical protein complement(1013682..1013915) Shigella dysenteriae Sd197 3797827 YP_402740.1 CDS yedE NC_007606.1 1013912 1015117 R Code: R; COG: COG2391; inner membrane protein complement(1013912..1015117) Shigella dysenteriae Sd197 3797828 YP_402741.1 CDS yedD NC_007606.1 1015304 1015717 D hypothetical protein 1015304..1015717 Shigella dysenteriae Sd197 3797829 YP_402742.1 CDS amyA NC_007606.1 1015751 1017238 R ''converts 1,4-alpha-D-glucans to maltodextrin''; alpha-amylase complement(1015751..1017238) Shigella dysenteriae Sd197 3797830 YP_402743.1 CDS fliS NC_007606.1 1017681 1018091 R flagellar biosynthesis; RflA activity; flagellin specific chaperone; flagellar protein FliS complement(1017681..1018091) Shigella dysenteriae Sd197 3797832 YP_402744.1 CDS fliD NC_007606.1 1018116 1019513 R flagellar biosynthesis; enables filament assembly; involved in flagellin assembly; flagellar capping protein complement(1018116..1019513) Shigella dysenteriae Sd197 3797833 YP_402745.1 CDS insB NC_007606.1 1021134 1021511 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(1021134..1021511) Shigella dysenteriae Sd197 3797835 YP_402746.1 CDS insA NC_007606.1 1021556 1021831 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(1021556..1021831) Shigella dysenteriae Sd197 3797836 YP_402747.1 CDS fliA NC_007606.1 1022538 1023257 D flagellar biosynthesis; regulation of flagellar operons; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 1022538..1023257 Shigella dysenteriae Sd197 3797837 YP_402748.1 CDS fliZ NC_007606.1 1023267 1023854 D ''expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence''; flagella biosynthesis protein FliZ 1023267..1023854 Shigella dysenteriae Sd197 3797838 YP_402749.1 CDS fliY NC_007606.1 1023942 1024742 D Code: ET; COG: COG0834; cystine transporter subunit 1023942..1024742 Shigella dysenteriae Sd197 3797839 YP_402750.2 CDS yedO NC_007606.1 1024847 1025833 D catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 1024847..1025833 Shigella dysenteriae Sd197 3797840 YP_402751.1 CDS yecS NC_007606.1 1025848 1026516 D formerly yecC; Code: E; COG: COG0765; transport system permease 1025848..1026516 Shigella dysenteriae Sd197 3797841 YP_402752.1 CDS yecC NC_007606.1 1026513 1027265 D Code: E; COG: COG1126; amino-acid ABC transporter ATP-binding protein YecC 1026513..1027265 Shigella dysenteriae Sd197 3797842 YP_009000686.1 CDS SDY_1101a NC_007606.1 1028108 1028380 D insertion element iso-IS1N protein InsA 1028108..1028380 Shigella dysenteriae Sd197 18262999 YP_402753.1 CDS SDY_1102 NC_007606.1 1028407 1028802 D Code: L; COG: COG1662; insertion element IS1 protein InsB 1028407..1028802 Shigella dysenteriae Sd197 3797844 YP_402754.1 CDS yecF NC_007606.1 1029059 1029283 R hypothetical protein complement(1029059..1029283) Shigella dysenteriae Sd197 3797845 YP_402755.1 CDS uvrY NC_007606.1 1029742 1030398 D in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 1029742..1030398 Shigella dysenteriae Sd197 3795445 YP_402756.2 CDS uvrC NC_007606.1 1030395 1032122 D repair of UV damage to DNA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1030395..1032122 Shigella dysenteriae Sd197 3795446 YP_402757.1 CDS pgsA NC_007606.1 1032286 1032834 D Code: I; COG: COG0558; phosphatidylglycerophosphate synthetase 1032286..1032834 Shigella dysenteriae Sd197 3795447 YP_402758.1 CDS yecA NC_007606.1 1033484 1034149 D Code: R; COG: COG3318; hypothetical protein 1033484..1034149 Shigella dysenteriae Sd197 3795451 YP_402759.1 CDS tyrP NC_007606.1 1034211 1035422 R Code: E; COG: COG0814; tyrosine-specific transporter complement(1034211..1035422) Shigella dysenteriae Sd197 3795452 YP_402760.1 CDS yecH NC_007606.1 1035614 1035853 D hypothetical protein 1035614..1035853 Shigella dysenteriae Sd197 3795453 YP_402761.1 CDS ftn NC_007606.1 1035891 1036388 R iron storage protein; cytoplasmic iron storage protein; ferritin complement(1035891..1036388) Shigella dysenteriae Sd197 3795454 YP_402762.1 CDS SDY_1114 NC_007606.1 1036559 1036882 R hypothetical protein complement(1036559..1036882) Shigella dysenteriae Sd197 3795455 YP_402763.1 CDS SDY_1115 NC_007606.1 1037093 1037488 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1037093..1037488) Shigella dysenteriae Sd197 3795456 YP_009000687.1 CDS SDY_1115a NC_007606.1 1037515 1037787 R insertion element iso-IS1N protein InsA complement(1037515..1037787) Shigella dysenteriae Sd197 18263000 YP_402764.1 CDS yecI NC_007606.1 1038290 1038793 D Code: P; COG: COG1528; ferritin 1038290..1038793 Shigella dysenteriae Sd197 3795457 YP_402765.1 CDS SDY_1117 NC_007606.1 1038872 1039123 R hypothetical protein complement(1038872..1039123) Shigella dysenteriae Sd197 3795458 YP_402766.1 CDS SDY_1119 NC_007606.1 1039412 1039807 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1039412..1039807) Shigella dysenteriae Sd197 3795460 YP_402768.1 CDS araF NC_007606.1 1040222 1041211 D Code: G; COG: COG1879; L-arabinose-binding protein 1040222..1041211 Shigella dysenteriae Sd197 3799748 YP_402769.1 CDS araG NC_007606.1 1041281 1042795 D Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose ABC transporter ATP-binding protein 1041281..1042795 Shigella dysenteriae Sd197 3799749 YP_402770.1 CDS araH NC_007606.1 1042807 1043796 D Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose ABC transporter permease 1042807..1043796 Shigella dysenteriae Sd197 3799750 YP_402771.1 CDS SDY_1123 NC_007606.1 1044340 1044642 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1044340..1044642 Shigella dysenteriae Sd197 3799751 YP_402773.1 CDS SDY_1125 NC_007606.1 1046365 1046706 R hypothetical protein complement(1046365..1046706) Shigella dysenteriae Sd197 3799753 YP_402775.1 CDS SDY_1127 NC_007606.1 1047596 1047970 R Code: R; COG: COG2372; hypothetical protein complement(1047596..1047970) Shigella dysenteriae Sd197 3799755 YP_402776.1 CDS holE NC_007606.1 1048109 1048339 D DNA polymerase III subunit theta 1048109..1048339 Shigella dysenteriae Sd197 3799756 YP_402777.1 CDS SDY_1129 NC_007606.1 1048441 1049097 D Code: R; COG: COG0388; hypothetical protein 1048441..1049097 Shigella dysenteriae Sd197 3799757 YP_402778.1 CDS SDY_1130 NC_007606.1 1049121 1049783 D 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1049121..1049783 Shigella dysenteriae Sd197 3799758 YP_402779.1 CDS ptrB NC_007606.1 1049780 1051840 R PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 complement(1049780..1051840) Shigella dysenteriae Sd197 3799759 YP_402780.1 CDS yebE NC_007606.1 1052049 1052708 R Code: S; COG: COG2979; hypothetical protein complement(1052049..1052708) Shigella dysenteriae Sd197 3799760 YP_402781.1 CDS yebF NC_007606.1 1053032 1053400 R secreted protein; unknown function; hypothetical protein complement(1053032..1053400) Shigella dysenteriae Sd197 3799761 YP_402782.1 CDS yebG NC_007606.1 1053455 1053745 R Code: S; COG: COG3141; DNA damage-inducible protein YebG complement(1053455..1053745) Shigella dysenteriae Sd197 3799762 YP_402783.1 CDS purT NC_007606.1 1053879 1055057 D ''non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis''; phosphoribosylglycinamide formyltransferase 2 1053879..1055057 Shigella dysenteriae Sd197 3799763 YP_402784.1 CDS eda NC_007606.1 1055113 1055754 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(1055113..1055754) Shigella dysenteriae Sd197 3799764 YP_402785.1 CDS edd NC_007606.1 1055791 1057602 R catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase complement(1055791..1057602) Shigella dysenteriae Sd197 3799765 YP_402786.1 CDS zwf NC_007606.1 1057837 1059312 R ''catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate''; glucose-6-phosphate 1-dehydrogenase complement(1057837..1059312) Shigella dysenteriae Sd197 3799766 YP_402789.1 CDS pykA NC_007606.1 1060646 1062088 D glucose stimulated; catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1060646..1062088 Shigella dysenteriae Sd197 3795462 YP_402790.1 CDS msbB NC_007606.1 1062219 1063190 R heat shock protein; ''Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA''; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase complement(1062219..1063190) Shigella dysenteriae Sd197 3795463 YP_402791.2 CDS yebA NC_007606.1 1063310 1064632 R Code: M; COG: COG0739; hypothetical protein complement(1063310..1064632) Shigella dysenteriae Sd197 3795464 YP_402792.2 CDS znuA NC_007606.1 1064648 1065580 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc ABC transporter substrate-binding protein complement(1064648..1065580) Shigella dysenteriae Sd197 3795465 YP_402793.1 CDS znuC NC_007606.1 1065659 1066414 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc ABC transporter ATPase 1065659..1066414 Shigella dysenteriae Sd197 3795466 YP_402794.1 CDS znuB NC_007606.1 1066411 1067196 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc ABC transporter permease 1066411..1067196 Shigella dysenteriae Sd197 3795467 YP_402795.1 CDS ruvB NC_007606.1 1067343 1068353 R branch migration; repair; promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(1067343..1068353) Shigella dysenteriae Sd197 3795468 YP_402796.1 CDS ruvA NC_007606.1 1068362 1068973 R branch migration; repair; plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(1068362..1068973) Shigella dysenteriae Sd197 3795469 YP_402797.2 CDS yebB NC_007606.1 1069248 1069850 D hypothetical protein 1069248..1069850 Shigella dysenteriae Sd197 3795470 YP_402798.1 CDS ruvC NC_007606.1 1069852 1070373 R resolution of structures; repair; endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(1069852..1070373) Shigella dysenteriae Sd197 3795471 YP_402799.1 CDS yebC NC_007606.1 1070408 1071148 R Code: S; COG: COG0217; hypothetical protein complement(1070408..1071148) Shigella dysenteriae Sd197 3795472 YP_402800.1 CDS ntpA NC_007606.1 1071177 1071629 R converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase complement(1071177..1071629) Shigella dysenteriae Sd197 3795473 YP_402801.1 CDS aspS NC_007606.1 1071747 1073519 R ''catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes''; aspartyl-tRNA synthetase complement(1071747..1073519) Shigella dysenteriae Sd197 3795474 YP_402802.1 CDS SDY_1154 NC_007606.1 1073829 1074083 D hypothetical protein 1073829..1074083 Shigella dysenteriae Sd197 3795475 YP_402803.1 CDS SDY_1155 NC_007606.1 1074275 1075471 D Code: L; COG: COG3547; insertion element IS110 transposase 1074275..1075471 Shigella dysenteriae Sd197 3795476 YP_402804.1 CDS insA NC_007606.1 1075974 1076249 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1075974..1076249 Shigella dysenteriae Sd197 3795477 YP_402806.1 CDS SDY_1158 NC_007606.1 1077771 1078073 D Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 1077771..1078073 Shigella dysenteriae Sd197 3795479 YP_402809.1 CDS insB NC_007606.1 1079466 1079918 R Code: L; COG: COG1662; insertion element IS1 4 protein InsB complement(1079466..1079918) Shigella dysenteriae Sd197 3796825 YP_402810.2 CDS SDY_1162 NC_007606.1 1079903 1080808 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(1079903..1080808) Shigella dysenteriae Sd197 3796826 YP_402811.1 CDS SDY_1163 NC_007606.1 1080766 1081131 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(1080766..1081131) Shigella dysenteriae Sd197 3796827 YP_402812.1 CDS insA NC_007606.1 1081224 1081499 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(1081224..1081499) Shigella dysenteriae Sd197 3796828 YP_402813.1 CDS SDY_1165 NC_007606.1 1081860 1082255 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1081860..1082255) Shigella dysenteriae Sd197 3796829 YP_402814.1 CDS SDY_1166 NC_007606.1 1082590 1083207 R hypothetical protein complement(1082590..1083207) Shigella dysenteriae Sd197 3796830 YP_402815.1 CDS SDY_1167 NC_007606.1 1083311 1083658 D hypothetical protein 1083311..1083658 Shigella dysenteriae Sd197 3796831 YP_402816.2 CDS yecN NC_007606.1 1083711 1084106 D Code: R; COG: COG3788; hypothetical protein 1083711..1084106 Shigella dysenteriae Sd197 3796832 YP_402817.1 CDS yecO NC_007606.1 1084147 1084890 D Code: QR; COG: COG0500; hypothetical protein 1084147..1084890 Shigella dysenteriae Sd197 3796833 YP_402818.1 CDS yecP NC_007606.1 1084887 1085858 D Code: QR; COG: COG0500; S-adenosyl-L-methionine-dependent methyltransferase 1084887..1085858 Shigella dysenteriae Sd197 3796834 YP_402819.1 CDS bisZ NC_007606.1 1086023 1088383 R Code: C; COG: COG0243; biotin sulfoxide reductase complement(1086023..1088383) Shigella dysenteriae Sd197 3796835 YP_009000688.1 CDS SDY_1174a NC_007606.1 1089317 1089589 R insertion element iso-IS1N protein InsA complement(1089317..1089589) Shigella dysenteriae Sd197 18263001 YP_402822.1 CDS SDY_1174 NC_007606.1 1090044 1090439 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1090044..1090439) Shigella dysenteriae Sd197 3796838 YP_009000689.1 CDS SDY_1176a NC_007606.1 1090466 1090738 R insertion element iso-IS1N protein InsA complement(1090466..1090738) Shigella dysenteriae Sd197 18263002 YP_402823.1 CDS SDY_1176 NC_007606.1 1091345 1091740 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1091345..1091740) Shigella dysenteriae Sd197 3796840 YP_009000690.1 CDS SDY_1178a NC_007606.1 1091767 1092039 R insertion element iso-IS1N protein InsA complement(1091767..1092039) Shigella dysenteriae Sd197 18263003 YP_402825.1 CDS cutC NC_007606.1 1092199 1092945 R Code: P; COG: COG3142; copper homeostasis protein CutC complement(1092199..1092945) Shigella dysenteriae Sd197 3796842 YP_402826.1 CDS yecM NC_007606.1 1092959 1093531 R Code: S; COG: COG3102; hypothetical protein complement(1092959..1093531) Shigella dysenteriae Sd197 3795480 YP_402827.1 CDS argS NC_007606.1 1093741 1095474 D ''catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase''; arginyl-tRNA synthetase 1093741..1095474 Shigella dysenteriae Sd197 3795481 YP_402828.1 CDS insA NC_007606.1 1095709 1095984 D Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 1095709..1095984 Shigella dysenteriae Sd197 3795482 YP_402829.1 CDS insB NC_007606.1 1096029 1096406 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1096029..1096406 Shigella dysenteriae Sd197 3795483 YP_402830.1 CDS flhE NC_007606.1 1097038 1097430 R flagellar protein complement(1097038..1097430) Shigella dysenteriae Sd197 3795484 YP_402831.1 CDS SDY_1185 NC_007606.1 1099045 1099440 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1099045..1099440) Shigella dysenteriae Sd197 3795486 YP_402832.1 CDS SDY_1186 NC_007606.1 1099853 1100155 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1099853..1100155 Shigella dysenteriae Sd197 3795487 YP_402833.1 CDS SDY_1187 NC_007606.1 1100296 1101009 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 1100296..1101009 Shigella dysenteriae Sd197 3795488 YP_402834.1 CDS motA NC_007606.1 1101937 1102824 R no effect on switching; With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA complement(1101937..1102824) Shigella dysenteriae Sd197 3795490 YP_402835.1 CDS flhC NC_007606.1 1102950 1103495 R transcription initiation factor; With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC complement(1102950..1103495) Shigella dysenteriae Sd197 3795491 YP_402836.1 CDS flhD NC_007606.1 1103498 1103857 R transcriptional initiation factor; with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD complement(1103498..1103857) Shigella dysenteriae Sd197 3795492 YP_402837.1 CDS yecG NC_007606.1 1104628 1105056 D ''ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress''; universal stress protein UspC 1104628..1105056 Shigella dysenteriae Sd197 3795493 YP_402838.1 CDS otsA NC_007606.1 1105063 1106487 R Code: G; COG: COG0380; trehalose-6-phosphate synthase complement(1105063..1106487) Shigella dysenteriae Sd197 3795494 YP_402839.1 CDS SDY_1195 NC_007606.1 1107028 1107867 R Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein complement(1107028..1107867) Shigella dysenteriae Sd197 3795496 YP_402840.1 CDS SDY_1196 NC_007606.1 1107894 1108220 R Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN complement(1107894..1108220) Shigella dysenteriae Sd197 3795497 YP_402841.1 CDS SDY_1197 NC_007606.1 1108193 1108963 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(1108193..1108963) Shigella dysenteriae Sd197 3795498 YP_402842.1 CDS SDY_1198 NC_007606.1 1109104 1109406 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(1109104..1109406) Shigella dysenteriae Sd197 3795596 YP_402843.1 CDS insA NC_007606.1 1109483 1109758 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1109483..1109758 Shigella dysenteriae Sd197 3795597 YP_402844.1 CDS insB NC_007606.1 1109803 1110180 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1109803..1110180 Shigella dysenteriae Sd197 3795598 YP_009000691.1 CDS SDY_1200a NC_007606.1 1110728 1111000 D insertion element iso-IS1N protein InsA 1110728..1111000 Shigella dysenteriae Sd197 18263004 YP_402845.1 CDS SDY_1201 NC_007606.1 1111027 1111422 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1111027..1111422 Shigella dysenteriae Sd197 3795599 YP_402846.1 CDS SDY_1202 NC_007606.1 1111815 1112834 D hypothetical protein 1111815..1112834 Shigella dysenteriae Sd197 3795600 YP_402847.1 CDS SDY_1203 NC_007606.1 1112809 1113204 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1112809..1113204) Shigella dysenteriae Sd197 3795601 YP_009000692.1 CDS SDY_1203a NC_007606.1 1113231 1113503 R insertion element iso-IS1N protein InsA complement(1113231..1113503) Shigella dysenteriae Sd197 18263005 YP_402848.1 CDS ypjA NC_007606.1 1113426 1116020 D Code: MU; COG: COG3468; ATPase 1113426..1116020 Shigella dysenteriae Sd197 3795602 YP_402849.1 CDS minE NC_007606.1 1116391 1116657 R reverses MinC inhibition of ftsZ ring formation; works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE complement(1116391..1116657) Shigella dysenteriae Sd197 3795603 YP_402850.1 CDS minD NC_007606.1 1116661 1117473 R cell division inhibitor, a membrane ATPase, activates minC; ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD complement(1116661..1117473) Shigella dysenteriae Sd197 3795604 YP_402851.1 CDS minC NC_007606.1 1117497 1118192 R cell division inhibitor, inhibits ftsZ ring formation; blocks the formation of polar Z-ring septums; septum formation inhibitor complement(1117497..1118192) Shigella dysenteriae Sd197 3795605 YP_402852.1 CDS SDY_1208 NC_007606.1 1118832 1119227 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1118832..1119227) Shigella dysenteriae Sd197 3795606 YP_009000693.1 CDS SDY_1208a NC_007606.1 1119254 1119526 R insertion element iso-IS1N protein InsA complement(1119254..1119526) Shigella dysenteriae Sd197 18263006 YP_402853.1 CDS ycgJ NC_007606.1 1119754 1120038 D hypothetical protein 1119754..1120038 Shigella dysenteriae Sd197 3795607 YP_402854.1 CDS ycgK NC_007606.1 1120158 1120559 R hypothetical protein complement(1120158..1120559) Shigella dysenteriae Sd197 3795608 YP_402855.1 CDS ycgL NC_007606.1 1120766 1121092 D Code: S; COG: COG3100; hypothetical protein 1120766..1121092 Shigella dysenteriae Sd197 3795609 YP_402856.1 CDS SDY_1212 NC_007606.1 1121164 1121823 D Code: Q; COG: COG0179; hypothetical protein 1121164..1121823 Shigella dysenteriae Sd197 3795610 YP_402857.2 CDS ycgN NC_007606.1 1121915 1122361 D Code: S; COG: COG2983; hypothetical protein 1121915..1122361 Shigella dysenteriae Sd197 3795611 YP_402858.1 CDS insA NC_007606.1 1122444 1122719 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1122444..1122719 Shigella dysenteriae Sd197 3795612 YP_402859.1 CDS insB NC_007606.1 1122764 1123141 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1122764..1123141 Shigella dysenteriae Sd197 3795613 YP_009000694.1 CDS SDY_1215a NC_007606.1 1123372 1123644 D insertion element iso-IS1N protein InsA 1123372..1123644 Shigella dysenteriae Sd197 18263007 YP_402860.1 CDS SDY_1216 NC_007606.1 1123671 1124066 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1123671..1124066 Shigella dysenteriae Sd197 3795614 YP_009000695.1 CDS SDY_1216a NC_007606.1 1124223 1124495 D insertion element iso-IS1N protein InsA 1124223..1124495 Shigella dysenteriae Sd197 18263008 YP_402862.1 CDS SDY_1218 NC_007606.1 1124522 1124917 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1124522..1124917 Shigella dysenteriae Sd197 3797183 YP_402863.1 CDS umuD NC_007606.1 1125536 1125955 D SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC; binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1125536..1125955 Shigella dysenteriae Sd197 3797185 YP_402864.1 CDS umuC NC_007606.1 1125955 1127214 D binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1125955..1127214 Shigella dysenteriae Sd197 3797186 YP_402865.1 CDS dsbB NC_007606.1 1127260 1127790 R reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella; disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B complement(1127260..1127790) Shigella dysenteriae Sd197 3797187 YP_402866.1 CDS nhaB NC_007606.1 1127936 1129477 R involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter complement(1127936..1129477) Shigella dysenteriae Sd197 3797188 YP_402867.1 CDS fadR NC_007606.1 1129699 1130418 D Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1129699..1130418 Shigella dysenteriae Sd197 3797189 YP_402868.1 CDS ycgB NC_007606.1 1130470 1132002 R Code: S; COG: COG2719; SpoVR family protein complement(1130470..1132002) Shigella dysenteriae Sd197 3797190 YP_402869.1 CDS dadA NC_007606.1 1132332 1133630 D catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1132332..1133630 Shigella dysenteriae Sd197 3797191 YP_402872.2 CDS SDY_1230 NC_007606.1 1136962 1138698 R the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter complement(1136962..1138698) Shigella dysenteriae Sd197 3797195 YP_402873.1 CDS ldcA NC_007606.1 1138793 1139707 R catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A complement(1138793..1139707) Shigella dysenteriae Sd197 3797197 YP_402874.1 CDS mltE NC_007606.1 1139693 1140418 D Code: M; COG: COG0741; murein transglycosylase E 1139693..1140418 Shigella dysenteriae Sd197 3797196 YP_402875.1 CDS ycgR NC_007606.1 1140420 1141154 R Code: M; COG: COG5581; hypothetical protein complement(1140420..1141154) Shigella dysenteriae Sd197 3797198 YP_402876.1 CDS ymgE NC_007606.1 1141355 1141609 D Code: S; COG: COG2261; hypothetical protein 1141355..1141609 Shigella dysenteriae Sd197 3797199 YP_402877.1 CDS prrA NC_007606.1 1141659 1143629 R probably tonB dependent; Code: P; COG: COG1629; outer membrane receptor complement(1141659..1143629) Shigella dysenteriae Sd197 3797200 YP_402878.1 CDS modD NC_007606.1 1143655 1144509 R involved in molybdenum transport; molybdenum transport protein ModD complement(1143655..1144509) Shigella dysenteriae Sd197 3797201 YP_009000696.1 CDS SDY_1238a NC_007606.1 1145010 1145282 D insertion element iso-IS1N protein InsA 1145010..1145282 Shigella dysenteriae Sd197 18263009 YP_402880.1 CDS SDY_1238 NC_007606.1 1145309 1145704 D Code: L; COG: COG1662; insertion element IS1 protein InsB 1145309..1145704 Shigella dysenteriae Sd197 3798350 YP_402881.1 CDS SDY_1239 NC_007606.1 1145679 1146092 R Code: QR; COG: COG0500; hypothetical protein complement(1145679..1146092) Shigella dysenteriae Sd197 3798351 YP_402882.1 CDS SDY_1240 NC_007606.1 1146102 1146860 R Code: PH; COG: COG1120; iron compound ABC transporter ATP-binding protein complement(1146102..1146860) Shigella dysenteriae Sd197 3798352 YP_402883.1 CDS SDY_1241 NC_007606.1 1146857 1147837 R Code: P; COG: COG0609; iron compound ABC transporter permease complement(1146857..1147837) Shigella dysenteriae Sd197 3798353 YP_402886.1 CDS SDY_1244 NC_007606.1 1149109 1149324 R insertion element iso-IS1n protein InsB complement(1149109..1149324) Shigella dysenteriae Sd197 3798356 YP_009000697.1 CDS SDY_1244a NC_007606.1 1149533 1149805 R insertion element iso-IS1N protein InsA complement(1149533..1149805) Shigella dysenteriae Sd197 18263010 YP_402887.1 CDS treA NC_007606.1 1149966 1151663 R periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase complement(1149966..1151663) Shigella dysenteriae Sd197 3798358 YP_402889.1 CDS SDY_1248 NC_007606.1 1153413 1153748 R Code: G; COG: COG2376; dihydroxyacetone kinase complement(1153413..1153748) Shigella dysenteriae Sd197 3798360 YP_402890.1 CDS SDY_1249 NC_007606.1 1153779 1154210 D hypothetical protein 1153779..1154210 Shigella dysenteriae Sd197 3798361 YP_402891.1 CDS SDY_1251 NC_007606.1 1157844 1158239 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1157844..1158239) Shigella dysenteriae Sd197 3798363 YP_009000698.1 CDS SDY_1251a NC_007606.1 1158266 1158538 R insertion element iso-IS1N protein InsA complement(1158266..1158538) Shigella dysenteriae Sd197 18263011 YP_402892.1 CDS ychF NC_007606.1 1158812 1159903 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(1158812..1159903) Shigella dysenteriae Sd197 3798364 YP_402893.1 CDS pth NC_007606.1 1160020 1160604 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(1160020..1160604) Shigella dysenteriae Sd197 3798365 YP_402894.1 CDS ychH NC_007606.1 1160882 1161160 D ''YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function''; hypothetical protein 1160882..1161160 Shigella dysenteriae Sd197 3798366 YP_402895.1 CDS ychM NC_007606.1 1161215 1162867 R role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM complement(1161215..1162867) Shigella dysenteriae Sd197 3798367 YP_402896.1 CDS prsA NC_007606.1 1163019 1163966 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1163019..1163966) Shigella dysenteriae Sd197 3798368 YP_402897.1 CDS ipk NC_007606.1 1164117 1164968 R An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(1164117..1164968) Shigella dysenteriae Sd197 3798783 YP_402898.1 CDS lolB NC_007606.1 1164968 1165591 R Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; molecular chaperone LolB complement(1164968..1165591) Shigella dysenteriae Sd197 3798784 YP_402899.1 CDS hemA NC_007606.1 1165805 1167061 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1165805..1167061 Shigella dysenteriae Sd197 3798785 YP_402900.1 CDS prfA NC_007606.1 1167103 1168185 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1167103..1168185 Shigella dysenteriae Sd197 3798786 YP_402901.1 CDS hemK NC_007606.1 1168185 1169018 D HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1168185..1169018 Shigella dysenteriae Sd197 3798787 YP_402902.1 CDS SDY_1262 NC_007606.1 1169015 1169407 D Code: S; COG: COG3094; transcriptional regulator 1169015..1169407 Shigella dysenteriae Sd197 3798788 YP_402903.1 CDS ychA NC_007606.1 1169411 1170220 D Code: S; COG: COG2912; transcriptional regulator 1169411..1170220 Shigella dysenteriae Sd197 3798789 YP_402904.1 CDS kdsA NC_007606.1 1170256 1171110 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1170256..1171110 Shigella dysenteriae Sd197 3798790 YP_402905.1 CDS SDY_1265 NC_007606.1 1171258 1171392 R hypothetical protein complement(1171258..1171392) Shigella dysenteriae Sd197 3798791 YP_402906.1 CDS chaA NC_007606.1 1171770 1172870 R Code: P; COG: COG0387; calcium/sodium:proton antiporter complement(1171770..1172870) Shigella dysenteriae Sd197 3798792 YP_402907.1 CDS insA NC_007606.1 1173140 1173415 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1173140..1173415 Shigella dysenteriae Sd197 3798793 YP_402909.1 CDS chaB NC_007606.1 1173917 1174147 D in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1173917..1174147 Shigella dysenteriae Sd197 3798795 YP_402910.1 CDS chaC NC_007606.1 1174284 1174940 D Code: P; COG: COG3703; cation transport regulator 1174284..1174940 Shigella dysenteriae Sd197 3798796 YP_402911.1 CDS ychN NC_007606.1 1175044 1175397 R Code: P; COG: COG1553; hypothetical protein complement(1175044..1175397) Shigella dysenteriae Sd197 3798797 YP_009000699.1 CDS SDY_1273a NC_007606.1 1175829 1176101 D insertion element iso-IS1N protein InsA 1175829..1176101 Shigella dysenteriae Sd197 18263012 YP_402913.1 CDS SDY_1273 NC_007606.1 1176128 1176523 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1176128..1176523 Shigella dysenteriae Sd197 3798799 YP_402914.1 CDS narL NC_007606.1 1177738 1178388 R pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes; two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL complement(1177738..1178388) Shigella dysenteriae Sd197 3798801 YP_402915.1 CDS narX NC_007606.1 1178381 1180177 R histidine protein kinase acts on NarL regulator; Code: T; COG: COG3850; nitrate/nitrite sensor protein NarX complement(1178381..1180177) Shigella dysenteriae Sd197 3796785 YP_402917.1 CDS narK NC_007606.1 1180516 1181907 D Code: P; COG: COG2223; nitrite extrusion protein 1180516..1181907 Shigella dysenteriae Sd197 3796787 YP_402918.1 CDS narG NC_007606.1 1182300 1186043 D Code: C; COG: COG5013; nitrate reductase 1 subunit alpha 1182300..1186043 Shigella dysenteriae Sd197 3796788 YP_402919.1 CDS narH NC_007606.1 1186040 1187578 D Code: C; COG: COG1140; nitrate reductase 1 subunit beta 1186040..1187578 Shigella dysenteriae Sd197 3796789 YP_402920.1 CDS narJ NC_007606.1 1187575 1188285 D Code: C; COG: COG2180; nitrate reductase 1 subunit delta 1187575..1188285 Shigella dysenteriae Sd197 3796790 YP_402921.1 CDS narI NC_007606.1 1188285 1188962 D Code: C; COG: COG2181; nitrate reductase 1 cytochrome b(NR) subunit gamma 1188285..1188962 Shigella dysenteriae Sd197 3796791 YP_402922.1 CDS purU NC_007606.1 1189567 1190409 R produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase complement(1189567..1190409) Shigella dysenteriae Sd197 3796793 YP_402923.1 CDS ychJ NC_007606.1 1190459 1190917 R Code: S; COG: COG3012; hypothetical protein complement(1190459..1190917) Shigella dysenteriae Sd197 3796794 YP_402925.1 CDS hnr NC_007606.1 1192028 1193041 D Code: T; COG: COG0784; response regulator of RpoS 1192028..1193041 Shigella dysenteriae Sd197 3796796 YP_402926.1 CDS galU NC_007606.1 1193243 1194151 D ''together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose''; UTP-glucose-1-phosphate uridylyltransferase 1193243..1194151 Shigella dysenteriae Sd197 3796797 YP_402927.1 CDS hns NC_007606.1 1194295 1194708 R HU, BH2, HD, NS; pleiotropic regulator; Code: R; COG: COG2916; global DNA-binding transcriptional dual regulator H-NS complement(1194295..1194708) Shigella dysenteriae Sd197 3796798 YP_402928.1 CDS tdk NC_007606.1 1195312 1195929 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1195312..1195929 Shigella dysenteriae Sd197 3796799 YP_402929.1 CDS SDY_1291 NC_007606.1 1195955 1196350 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1195955..1196350) Shigella dysenteriae Sd197 3796800 YP_402930.1 CDS SDY_1292 NC_007606.1 1197041 1198174 D Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG 1197041..1198174 Shigella dysenteriae Sd197 3796801 YP_402931.1 CDS insA NC_007606.1 1198225 1198500 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1198225..1198500 Shigella dysenteriae Sd197 3796802 YP_402933.1 CDS adhE NC_007606.1 1199206 1201881 R Code: C; COG: COG1454; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1199206..1201881) Shigella dysenteriae Sd197 3796690 YP_009000700.1 CDS SDY_1294a NC_007606.1 1202289 1202561 D insertion element iso-IS1N protein InsA 1202289..1202561 Shigella dysenteriae Sd197 18263014 YP_402934.1 CDS SDY_1296 NC_007606.1 1202588 1202983 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1202588..1202983 Shigella dysenteriae Sd197 3796691 YP_402935.1 CDS insA NC_007606.1 1203112 1203387 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1203112..1203387 Shigella dysenteriae Sd197 3796692 YP_402936.1 CDS insB NC_007606.1 1203432 1203809 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1203432..1203809 Shigella dysenteriae Sd197 3796693 YP_402937.1 CDS SDY_1299 NC_007606.1 1204066 1204461 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1204066..1204461) Shigella dysenteriae Sd197 3796694 YP_009000701.1 CDS SDY_1301a NC_007606.1 1204488 1204760 R insertion element iso-IS1N protein InsA complement(1204488..1204760) Shigella dysenteriae Sd197 18263015 YP_402939.1 CDS oppA NC_007606.1 1205560 1207191 D oligopeptide transport; periplasmic binding protein; Code: E; COG: COG4166; hypothetical protein 1205560..1207191 Shigella dysenteriae Sd197 3796696 YP_402940.1 CDS oppB NC_007606.1 1207277 1208197 D Code: EP; COG: COG0601; oligopeptide transporter permease 1207277..1208197 Shigella dysenteriae Sd197 3796697 YP_402941.1 CDS oppC NC_007606.1 1208212 1209120 D Code: EP; COG: COG1173; hypothetical protein 1208212..1209120 Shigella dysenteriae Sd197 3796698 YP_402942.1 CDS oppD NC_007606.1 1209132 1210145 D Code: EP; COG: COG0444; oligopeptide ABC transporter ATP-binding protein 1209132..1210145 Shigella dysenteriae Sd197 3796699 YP_402943.1 CDS oppF NC_007606.1 1210142 1211146 D Code: E; COG: COG4608; hypothetical protein 1210142..1211146 Shigella dysenteriae Sd197 3796700 YP_402944.2 CDS SDY_1306 NC_007606.1 1211199 1211528 R highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein complement(1211199..1211528) Shigella dysenteriae Sd197 3796701 YP_402945.1 CDS cls NC_007606.1 1211563 1213023 R a major membrane phospholipid; novobiocin sensitivity; catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase complement(1211563..1213023) Shigella dysenteriae Sd197 3796702 YP_402946.1 CDS kch NC_007606.1 1213393 1214646 R Code: P; COG: COG1226; voltage-gated potassium channel complement(1213393..1214646) Shigella dysenteriae Sd197 3796703 YP_402947.2 CDS yciI NC_007606.1 1214946 1215242 R ''unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity''; hypothetical protein complement(1214946..1215242) Shigella dysenteriae Sd197 3796704 YP_402948.1 CDS SDY_1310 NC_007606.1 1216727 1217092 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 1216727..1217092 Shigella dysenteriae Sd197 3796705 YP_402949.2 CDS SDY_1311 NC_007606.1 1217050 1217928 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1217050..1217928 Shigella dysenteriae Sd197 3796706 YP_402950.1 CDS SDY_1312 NC_007606.1 1218133 1218684 D Code: L; COG: COG1961; DNA invertase-like protein 1218133..1218684 Shigella dysenteriae Sd197 3796707 YP_402951.1 CDS SDY_1313 NC_007606.1 1218765 1219067 D Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 1218765..1219067 Shigella dysenteriae Sd197 3796708 YP_402954.1 CDS tonB NC_007606.1 1220191 1220910 D energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins; ''membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins''; transporter 1220191..1220910 Shigella dysenteriae Sd197 3798748 YP_402955.1 CDS yciA NC_007606.1 1220950 1221348 R YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins; acyl-CoA thioester hydrolase complement(1220950..1221348) Shigella dysenteriae Sd197 3798749 YP_402956.1 CDS yciB NC_007606.1 1221453 1221992 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(1221453..1221992) Shigella dysenteriae Sd197 3798750 YP_402957.1 CDS yciC NC_007606.1 1222022 1222765 R hypothetical protein complement(1222022..1222765) Shigella dysenteriae Sd197 3798751 YP_402958.1 CDS yciD NC_007606.1 1223122 1223760 D receptor for colicin S4; outer membrane protein W 1223122..1223760 Shigella dysenteriae Sd197 3798752 YP_402959.1 CDS yciE NC_007606.1 1223820 1224329 R Code: S; COG: COG3685; hypothetical protein complement(1223820..1224329) Shigella dysenteriae Sd197 3798753 YP_402961.1 CDS insA NC_007606.1 1224614 1224889 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1224614..1224889 Shigella dysenteriae Sd197 3798755 YP_402962.1 CDS insB NC_007606.1 1224934 1225311 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1224934..1225311 Shigella dysenteriae Sd197 3798756 YP_009000702.1 CDS SDY_1324a NC_007606.1 1225496 1225768 D insertion element iso-IS1N protein InsA 1225496..1225768 Shigella dysenteriae Sd197 18263016 YP_402964.1 CDS SDY_1326 NC_007606.1 1226204 1226506 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1226204..1226506 Shigella dysenteriae Sd197 3798758 YP_402966.1 CDS trpA NC_007606.1 1227673 1228479 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1227673..1228479) Shigella dysenteriae Sd197 3798760 YP_402967.1 CDS trpB NC_007606.1 1228479 1229672 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1228479..1229672) Shigella dysenteriae Sd197 3798761 YP_402968.1 CDS trpC NC_007606.1 1229684 1231045 R monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase complement(1229684..1231045) Shigella dysenteriae Sd197 3798762 YP_402969.1 CDS trpD NC_007606.1 1231046 1232641 R glutamine amidotransferase and phosphoribosylanthranilate transferase; bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase complement(1231046..1232641) Shigella dysenteriae Sd197 3798763 YP_402970.1 CDS trpE NC_007606.1 1232641 1234203 R ''with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine''; anthranilate synthase component I complement(1232641..1234203) Shigella dysenteriae Sd197 3798764 YP_402972.1 CDS yciV NC_007606.1 1234477 1235358 D Code: R; COG: COG0613; metal-dependent phosphoesterase 1234477..1235358 Shigella dysenteriae Sd197 3797553 YP_402973.1 CDS yciO NC_007606.1 1235319 1235975 D Code: J; COG: COG0009; hypothetical protein 1235319..1235975 Shigella dysenteriae Sd197 3797554 YP_402974.1 CDS insA NC_007606.1 1236040 1236315 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1236040..1236315 Shigella dysenteriae Sd197 3797555 YP_402975.1 CDS insB NC_007606.1 1236360 1236737 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1236360..1236737 Shigella dysenteriae Sd197 3797556 YP_402976.1 CDS SDY_1338 NC_007606.1 1236766 1237191 D hypothetical protein 1236766..1237191 Shigella dysenteriae Sd197 3797557 YP_402977.1 CDS yciL NC_007606.1 1237404 1238276 D catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1237404..1238276 Shigella dysenteriae Sd197 3797558 YP_402978.1 CDS btuR NC_007606.1 1238316 1238906 R ''catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide''; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(1238316..1238906) Shigella dysenteriae Sd197 3797559 YP_402979.1 CDS yciK NC_007606.1 1238903 1239661 R Code: IQR; COG: COG1028; short chain dehydrogenase complement(1238903..1239661) Shigella dysenteriae Sd197 3797560 YP_402980.1 CDS sohB NC_007606.1 1239881 1240921 D SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1239881..1240921 Shigella dysenteriae Sd197 3797561 YP_402981.1 CDS yciN NC_007606.1 1240957 1241208 R hypothetical protein complement(1240957..1241208) Shigella dysenteriae Sd197 3797562 YP_402982.1 CDS topA NC_007606.1 1241588 1244185 D ''catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity''; DNA topoisomerase I 1241588..1244185 Shigella dysenteriae Sd197 3797563 YP_402983.1 CDS cysB NC_007606.1 1244395 1245369 D LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1244395..1245369 Shigella dysenteriae Sd197 3797564 YP_402984.1 CDS insB NC_007606.1 1245629 1246006 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(1245629..1246006) Shigella dysenteriae Sd197 3797565 YP_402985.1 CDS insA NC_007606.1 1246051 1246326 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(1246051..1246326) Shigella dysenteriae Sd197 3797566 YP_402986.1 CDS SDY_1348 NC_007606.1 1246440 1246604 D hypothetical protein 1246440..1246604 Shigella dysenteriae Sd197 3797567 YP_402987.1 CDS yciX NC_007606.1 1246586 1246774 D hypothetical protein 1246586..1246774 Shigella dysenteriae Sd197 3797568 YP_402989.1 CDS SDY_1352 NC_007606.1 1250093 1250395 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(1250093..1250395) Shigella dysenteriae Sd197 3797571 YP_402990.1 CDS ribA NC_007606.1 1251155 1251745 R ''catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate''; GTP cyclohydrolase II complement(1251155..1251745) Shigella dysenteriae Sd197 3797046 YP_402991.1 CDS pgpB NC_007606.1 1251915 1252679 D Code: I; COG: COG0671; phosphatidylglycerophosphatase B 1251915..1252679 Shigella dysenteriae Sd197 3797047 YP_402992.1 CDS yciS NC_007606.1 1252828 1253136 D Code: S; COG: COG3771; hypothetical protein 1252828..1253136 Shigella dysenteriae Sd197 3797048 YP_402993.1 CDS yciM NC_007606.1 1253143 1254312 D Code: G; COG: COG2956; hypothetical protein 1253143..1254312 Shigella dysenteriae Sd197 3797049 YP_402994.1 CDS pyrF NC_007606.1 1254505 1255242 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1254505..1255242 Shigella dysenteriae Sd197 3797050 YP_402995.1 CDS yciH NC_007606.1 1255239 1255568 D involved in start site selection during the initiation of translation; translation initiation factor Sui1 1255239..1255568 Shigella dysenteriae Sd197 3797051 YP_402996.1 CDS insB NC_007606.1 1255866 1256243 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(1255866..1256243) Shigella dysenteriae Sd197 3797052 YP_402997.1 CDS insA NC_007606.1 1256288 1256563 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(1256288..1256563) Shigella dysenteriae Sd197 3797053 YP_402998.1 CDS SDY_1361 NC_007606.1 1256729 1257478 R Code: KG; COG: COG1349; DeoR-type transcriptional regulator complement(1256729..1257478) Shigella dysenteriae Sd197 3797054 YP_402999.1 CDS SDY_1362 NC_007606.1 1257568 1257741 R hypothetical protein complement(1257568..1257741) Shigella dysenteriae Sd197 3797055 YP_403000.1 CDS insA NC_007606.1 1259930 1260205 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1259930..1260205 Shigella dysenteriae Sd197 3797057 YP_403001.1 CDS insB NC_007606.1 1260250 1260627 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1260250..1260627 Shigella dysenteriae Sd197 3797058 YP_403002.1 CDS rnb NC_007606.1 1260887 1262821 R mRNA degradation; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II complement(1260887..1262821) Shigella dysenteriae Sd197 3797059 YP_403004.1 CDS fabI NC_007606.1 1264141 1264929 R Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase complement(1264141..1264929) Shigella dysenteriae Sd197 3797061 YP_403005.1 CDS SDY_1369 NC_007606.1 1265366 1265761 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1265366..1265761) Shigella dysenteriae Sd197 3797062 YP_403006.1 CDS SDY_1370 NC_007606.1 1265956 1266249 D hypothetical protein 1265956..1266249 Shigella dysenteriae Sd197 3797063 YP_403007.1 CDS SDY_1371 NC_007606.1 1266246 1266641 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1266246..1266641) Shigella dysenteriae Sd197 3797064 YP_009000703.1 CDS SDY_1370a NC_007606.1 1266668 1266940 R insertion element iso-IS1N protein InsA complement(1266668..1266940) Shigella dysenteriae Sd197 18263017 YP_403008.1 CDS SDY_1372 NC_007606.1 1267290 1270391 D Code: V; COG: COG0841; multidrug-efflux transport protein 1267290..1270391 Shigella dysenteriae Sd197 3797065 YP_403011.1 CDS SDY_1375 NC_007606.1 1271783 1272934 D Code: GEPR; COG: COG0477; membrane transport protein 1271783..1272934 Shigella dysenteriae Sd197 3796541 YP_403012.1 CDS SDY_1376 NC_007606.1 1272983 1274179 R Code: L; COG: COG3547; insertion element IS110 transposase complement(1272983..1274179) Shigella dysenteriae Sd197 3796542 YP_403013.1 CDS sapF NC_007606.1 1274438 1275244 R Code: V; COG: COG4167; peptide ABC transporter ATP-binding protein complement(1274438..1275244) Shigella dysenteriae Sd197 3796543 YP_403014.1 CDS sapD NC_007606.1 1275246 1276238 R Code: V; COG: COG4170; peptide ABC transporter ATP-binding protein complement(1275246..1276238) Shigella dysenteriae Sd197 3796544 YP_403015.1 CDS sapC NC_007606.1 1276238 1277128 R Code: V; COG: COG4171; SapC protein complement(1276238..1277128) Shigella dysenteriae Sd197 3796545 YP_403016.1 CDS int NC_007606.1 1277263 1278492 D Code: L; COG: COG0582; integrase 1277263..1278492 Shigella dysenteriae Sd197 3796546 YP_403017.1 CDS insA NC_007606.1 1278706 1278981 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1278706..1278981 Shigella dysenteriae Sd197 3796547 YP_403018.1 CDS SDY_1382 NC_007606.1 1279827 1280507 R exonuclease complement(1279827..1280507) Shigella dysenteriae Sd197 3796548 YP_403019.1 CDS bet NC_007606.1 1280504 1281289 R recombination protein Bet complement(1280504..1281289) Shigella dysenteriae Sd197 3796549 YP_403020.1 CDS gam NC_007606.1 1281295 1281591 R host-nuclease inhibitor protein Gam complement(1281295..1281591) Shigella dysenteriae Sd197 3796550 YP_403021.1 CDS SDY_1385 NC_007606.1 1281588 1282082 R hypothetical protein complement(1281588..1282082) Shigella dysenteriae Sd197 3796551 YP_403022.1 CDS SDY_1386 NC_007606.1 1282475 1282777 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1282475..1282777 Shigella dysenteriae Sd197 3796552 YP_403025.1 CDS stxA NC_007606.1 1283865 1284812 D Shiga toxin subunit A 1283865..1284812 Shigella dysenteriae Sd197 3796555 YP_403026.1 CDS stxB NC_007606.1 1284822 1285091 D Shiga toxin subunit B 1284822..1285091 Shigella dysenteriae Sd197 3796556 YP_403027.1 CDS yjhS NC_007606.1 1285601 1287511 D Code: L; COG: COG2801; hypothetical protein 1285601..1287511 Shigella dysenteriae Sd197 3796557 YP_403028.1 CDS SDY_1392 NC_007606.1 1287698 1288105 D hypothetical protein 1287698..1288105 Shigella dysenteriae Sd197 3799150 YP_403029.1 CDS SDY_1393 NC_007606.1 1288182 1288397 D lysis protein S 1288182..1288397 Shigella dysenteriae Sd197 3799151 YP_403030.1 CDS SDY_1394 NC_007606.1 1288402 1288935 D Code: R; COG: COG3772; endolysin 1288402..1288935 Shigella dysenteriae Sd197 3799152 YP_403031.1 CDS SDY_1395 NC_007606.1 1289159 1289998 R Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein complement(1289159..1289998) Shigella dysenteriae Sd197 3799153 YP_403032.1 CDS insA NC_007606.1 1290194 1290469 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1290194..1290469 Shigella dysenteriae Sd197 3799154 YP_403033.1 CDS insB NC_007606.1 1290514 1290891 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1290514..1290891 Shigella dysenteriae Sd197 3799155 YP_403034.1 CDS ycjX NC_007606.1 1291370 1292767 D Code: R; COG: COG3106; hypothetical protein 1291370..1292767 Shigella dysenteriae Sd197 3799157 YP_403035.1 CDS ycjF NC_007606.1 1292764 1293798 D Code: S; COG: COG3768; hypothetical protein 1292764..1293798 Shigella dysenteriae Sd197 3799158 YP_403036.1 CDS tyrR NC_007606.1 1293973 1295514 D transcriptional regulation of aroF, aroG, tyrA and aromatic amino acid transport; regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1293973..1295514 Shigella dysenteriae Sd197 3799159 YP_403037.1 CDS tpx NC_007606.1 1295558 1296064 R antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase complement(1295558..1296064) Shigella dysenteriae Sd197 3799160 YP_403038.1 CDS ycjG NC_007606.1 1296141 1297148 D Code: MR; COG: COG4948; muconate cycloisomerase I 1296141..1297148 Shigella dysenteriae Sd197 3799161 YP_403039.1 CDS ycjI NC_007606.1 1297123 1297911 R Code: E; COG: COG2866; murein peptide amidase A complement(1297123..1297911) Shigella dysenteriae Sd197 3799162 YP_403040.1 CDS SDY_1405 NC_007606.1 1298299 1298694 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1298299..1298694) Shigella dysenteriae Sd197 3799163 YP_009000704.1 CDS SDY_1407a NC_007606.1 1298721 1298993 R insertion element iso-IS1N protein InsA complement(1298721..1298993) Shigella dysenteriae Sd197 18263018 YP_009000705.1 CDS SDY_1408a NC_007606.1 1299405 1299677 D insertion element iso-IS1N protein InsA 1299405..1299677 Shigella dysenteriae Sd197 18263019 YP_403042.1 CDS SDY_1407 NC_007606.1 1299704 1300099 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1299704..1300099 Shigella dysenteriae Sd197 3799165 YP_403043.1 CDS ycjZ NC_007606.1 1300229 1301128 D Code: K; COG: COG0583; LysR family transcriptional regulator 1300229..1301128 Shigella dysenteriae Sd197 3799166 YP_403044.1 CDS SDY_1409 NC_007606.1 1301444 1303078 D Code: E; COG: COG4166; transport periplasmic protein 1301444..1303078 Shigella dysenteriae Sd197 3799167 YP_403045.1 CDS SDY_1410 NC_007606.1 1303129 1304160 R Code: M; COG: COG0668; hypothetical protein complement(1303129..1304160) Shigella dysenteriae Sd197 3799168 YP_403046.1 CDS insB NC_007606.1 1304541 1304918 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(1304541..1304918) Shigella dysenteriae Sd197 3799169 YP_403047.1 CDS insA NC_007606.1 1304963 1305238 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(1304963..1305238) Shigella dysenteriae Sd197 3797918 YP_403048.1 CDS ydaA NC_007606.1 1305488 1306438 R with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE complement(1305488..1306438) Shigella dysenteriae Sd197 3797919 YP_403049.1 CDS SDY_1414 NC_007606.1 1306532 1306927 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1306532..1306927) Shigella dysenteriae Sd197 3797920 YP_009000706.1 CDS SDY_1414a NC_007606.1 1306954 1307226 R insertion element iso-IS1N protein InsA complement(1306954..1307226) Shigella dysenteriae Sd197 18263020 YP_403050.1 CDS fnr NC_007606.1 1307364 1308116 R transcriptional regulation of aerobic, anaerobic respiration, osmotic balance; Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator complement(1307364..1308116) Shigella dysenteriae Sd197 3797921 YP_403051.1 CDS ogt NC_007606.1 1308311 1308826 R Code: L; COG: COG0350; O-6-alkylguanine-DNA:cysteine-protein methyltransferase complement(1308311..1308826) Shigella dysenteriae Sd197 3797922 YP_009000707.1 CDS SDY_1416a NC_007606.1 1309446 1309718 D insertion element iso-IS1N protein InsA 1309446..1309718 Shigella dysenteriae Sd197 18263021 YP_403053.1 CDS SDY_1418 NC_007606.1 1309745 1310140 D Code: L; COG: COG1662; insertion element IS1 protein InsB 1309745..1310140 Shigella dysenteriae Sd197 3797924 YP_403054.1 CDS ydaL NC_007606.1 1310832 1311395 D Code: S; COG: COG2840; hypothetical protein 1310832..1311395 Shigella dysenteriae Sd197 3797925 YP_403055.1 CDS SDY_1420 NC_007606.1 1311416 1311715 R Code: T; COG: COG2199; hypothetical protein complement(1311416..1311715) Shigella dysenteriae Sd197 3797926 YP_403056.1 CDS SDY_1421 NC_007606.1 1311754 1312056 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1311754..1312056 Shigella dysenteriae Sd197 3797927 YP_403057.1 CDS SDY_1422 NC_007606.1 1312197 1313003 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 1312197..1313003 Shigella dysenteriae Sd197 3797928 YP_403058.1 CDS SDY_1423 NC_007606.1 1312936 1313916 R Code: T; COG: COG2202; hypothetical protein complement(1312936..1313916) Shigella dysenteriae Sd197 3797929 YP_403059.1 CDS zntB NC_007606.1 1314171 1315154 D Code: P; COG: COG0598; zinc transporter 1314171..1315154 Shigella dysenteriae Sd197 3797930 YP_403060.1 CDS ydaO NC_007606.1 1316535 1317470 R TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase complement(1316535..1317470) Shigella dysenteriae Sd197 3797932 YP_403061.1 CDS SDY_1427 NC_007606.1 1317522 1317761 R hypothetical protein complement(1317522..1317761) Shigella dysenteriae Sd197 3797933 YP_403064.1 CDS insA NC_007606.1 1319000 1319275 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(1319000..1319275) Shigella dysenteriae Sd197 3797936 YP_009000708.1 CDS SDY_1430a NC_007606.1 1319801 1320073 D insertion element iso-IS1N protein InsA 1319801..1320073 Shigella dysenteriae Sd197 18263022 YP_403065.1 CDS SDY_1431 NC_007606.1 1320100 1320495 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1320100..1320495 Shigella dysenteriae Sd197 3796022 YP_403066.1 CDS relF NC_007606.1 1321016 1321171 D polypeptide destructive to membrane potential 1321016..1321171 Shigella dysenteriae Sd197 3796023 YP_403067.1 CDS rem NC_007606.1 1321388 1321639 D hypothetical protein 1321388..1321639 Shigella dysenteriae Sd197 3796024 YP_403068.1 CDS SDY_1434 NC_007606.1 1321986 1323035 D hypothetical protein 1321986..1323035 Shigella dysenteriae Sd197 3796025 YP_403069.1 CDS SDY_1435 NC_007606.1 1323048 1323422 D Code: L; COG: COG4570; endonuclease of prophage CP-933O 1323048..1323422 Shigella dysenteriae Sd197 3796026 YP_403070.1 CDS SDY_1436 NC_007606.1 1323419 1324240 D antitermination protein Q 1323419..1324240 Shigella dysenteriae Sd197 3796027 YP_403071.1 CDS insA NC_007606.1 1324726 1325001 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1324726..1325001 Shigella dysenteriae Sd197 3796030 YP_403072.1 CDS insB NC_007606.1 1325046 1325423 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1325046..1325423 Shigella dysenteriae Sd197 3796031 YP_009000709.1 CDS SDY_1440a NC_007606.1 1325914 1326186 D insertion element iso-IS1N protein InsA 1325914..1326186 Shigella dysenteriae Sd197 18263023 YP_403074.1 CDS SDY_1442 NC_007606.1 1326213 1326608 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1326213..1326608 Shigella dysenteriae Sd197 3796033 YP_403075.1 CDS SDY_1443 NC_007606.1 1326609 1326815 D hypothetical protein 1326609..1326815 Shigella dysenteriae Sd197 3796034 YP_403076.1 CDS SDY_1444 NC_007606.1 1326985 1327287 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1326985..1327287 Shigella dysenteriae Sd197 3796035 YP_403078.1 CDS SDY_1446 NC_007606.1 1328535 1328930 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1328535..1328930) Shigella dysenteriae Sd197 3796037 YP_009000710.1 CDS SDY_1466a NC_007606.1 1328957 1329229 R insertion element iso-IS1N protein InsA complement(1328957..1329229) Shigella dysenteriae Sd197 18263024 YP_403080.1 CDS SDY_1448 NC_007606.1 1329300 1329542 D hypothetical protein 1329300..1329542 Shigella dysenteriae Sd197 3796039 YP_403081.1 CDS SDY_1449 NC_007606.1 1329900 1330265 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 1329900..1330265 Shigella dysenteriae Sd197 3799402 YP_403082.2 CDS SDY_1450 NC_007606.1 1330223 1331128 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1330223..1331128 Shigella dysenteriae Sd197 3799403 YP_009000711.1 CDS SDY_1450a NC_007606.1 1331147 1331362 D phage lysis protein 1331147..1331362 Shigella dysenteriae Sd197 18263025 YP_009000712.1 CDS SDY_1451a NC_007606.1 1331367 1331552 D prophage protein 1331367..1331552 Shigella dysenteriae Sd197 18263026 YP_403084.1 CDS SDY_1452 NC_007606.1 1332447 1332749 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(1332447..1332749) Shigella dysenteriae Sd197 3799405 YP_403086.1 CDS sitD NC_007606.1 1333997 1334854 R Code: P; COG: COG1108; iron ABC transporter permease complement(1333997..1334854) Shigella dysenteriae Sd197 3799407 YP_403087.1 CDS sitC NC_007606.1 1334851 1335708 R Code: P; COG: COG1108; iron ABC transporter permease complement(1334851..1335708) Shigella dysenteriae Sd197 3799408 YP_403088.1 CDS sitB NC_007606.1 1335705 1336532 R Code: P; COG: COG1121; iron ABC transporter ATP-binding protein complement(1335705..1336532) Shigella dysenteriae Sd197 3799409 YP_403089.1 CDS sitA NC_007606.1 1336532 1337446 R Code: P; COG: COG0803; iron ABC transporter substrate-binding protein complement(1336532..1337446) Shigella dysenteriae Sd197 3799410 YP_403090.1 CDS ynaF NC_007606.1 1338033 1338539 R Code: T; COG: COG0589; filament protein complement(1338033..1338539) Shigella dysenteriae Sd197 3799411 YP_403091.1 CDS SDY_1460 NC_007606.1 1339983 1340696 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(1339983..1340696) Shigella dysenteriae Sd197 3799413 YP_403092.1 CDS ydbK NC_007606.1 1341364 1344888 R Code: C; COG: COG0674; oxidoreductase Fe-S subunit complement(1341364..1344888) Shigella dysenteriae Sd197 3799414 YP_403093.1 CDS SDY_1462 NC_007606.1 1345150 1345416 D Code: R; COG: COG3042; hypothetical protein 1345150..1345416 Shigella dysenteriae Sd197 3799415 YP_403094.1 CDS ldhA NC_007606.1 1345935 1346924 R Code: CHR; COG: COG1052; fermentative D-lactate dehydrogenase complement(1345935..1346924) Shigella dysenteriae Sd197 3799417 YP_403095.1 CDS ydbH NC_007606.1 1347132 1349771 D hypothetical protein 1347132..1349771 Shigella dysenteriae Sd197 3799418 YP_403096.1 CDS ynbE NC_007606.1 1349768 1349953 D hypothetical protein 1349768..1349953 Shigella dysenteriae Sd197 3799419 YP_009000713.1 CDS SDY_1468a NC_007606.1 1350245 1350517 D insertion element iso-IS1N protein InsA 1350245..1350517 Shigella dysenteriae Sd197 18263027 YP_403098.1 CDS SDY_1468 NC_007606.1 1350544 1350939 D Code: L; COG: COG1662; insertion element IS1 protein InsB 1350544..1350939 Shigella dysenteriae Sd197 3797988 YP_403099.1 CDS insA NC_007606.1 1351167 1351442 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1351167..1351442 Shigella dysenteriae Sd197 3797989 YP_403100.1 CDS insB NC_007606.1 1351487 1351864 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1351487..1351864 Shigella dysenteriae Sd197 3797990 YP_403101.1 CDS SDY_1471 NC_007606.1 1352005 1352562 D hypothetical protein 1352005..1352562 Shigella dysenteriae Sd197 3797991 YP_403102.1 CDS SDY_1472 NC_007606.1 1352732 1353346 D Code: I; COG: COG0558; hypothetical protein 1352732..1353346 Shigella dysenteriae Sd197 3797992 YP_403103.1 CDS SDY_1473 NC_007606.1 1353321 1353716 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1353321..1353716) Shigella dysenteriae Sd197 3797993 YP_009000714.1 CDS SDY_1469a NC_007606.1 1353743 1354015 R insertion element iso-IS1N protein InsA complement(1353743..1354015) Shigella dysenteriae Sd197 18263028 YP_403104.1 CDS aroD NC_007606.1 1354383 1355141 R catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase complement(1354383..1355141) Shigella dysenteriae Sd197 3797994 YP_403105.1 CDS ydiB NC_007606.1 1355172 1356065 R YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase complement(1355172..1356065) Shigella dysenteriae Sd197 3797995 YP_403106.1 CDS SDY_1476 NC_007606.1 1356043 1356258 R insertion element iso-IS1n protein InsB complement(1356043..1356258) Shigella dysenteriae Sd197 3797996 YP_009000715.1 CDS SDY_1476a NC_007606.1 1356464 1356736 R insertion element iso-IS1N protein InsA complement(1356464..1356736) Shigella dysenteriae Sd197 18263029 YP_403107.1 CDS SDY_1477 NC_007606.1 1356823 1357176 R hypothetical protein complement(1356823..1357176) Shigella dysenteriae Sd197 3797997 YP_403108.1 CDS insB NC_007606.1 1357273 1357650 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(1357273..1357650) Shigella dysenteriae Sd197 3797998 YP_403109.1 CDS insA NC_007606.1 1357695 1357970 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(1357695..1357970) Shigella dysenteriae Sd197 3797999 YP_403111.1 CDS SDY_1481 NC_007606.1 1358895 1359197 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(1358895..1359197) Shigella dysenteriae Sd197 3798001 YP_403112.1 CDS insA NC_007606.1 1359291 1359566 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1359291..1359566 Shigella dysenteriae Sd197 3798002 YP_403113.1 CDS SDY_1483 NC_007606.1 1359923 1360801 R Code: GEPR; COG: COG0477; transport system permease complement(1359923..1360801) Shigella dysenteriae Sd197 3798003 YP_403114.1 CDS SDY_1484 NC_007606.1 1360779 1361174 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1360779..1361174) Shigella dysenteriae Sd197 3798004 YP_009000716.1 CDS SDY_1482a NC_007606.1 1361201 1361473 R insertion element iso-IS1N protein InsA complement(1361201..1361473) Shigella dysenteriae Sd197 18263030 YP_403115.1 CDS yeaF NC_007606.1 1361643 1362389 D Code: M; COG: COG3713; hypothetical protein 1361643..1362389 Shigella dysenteriae Sd197 3798005 YP_403116.1 CDS SDY_1486 NC_007606.1 1362479 1363330 D Code: R; COG: COG0656; aldehyde reductase 1362479..1363330 Shigella dysenteriae Sd197 3798006 YP_403117.1 CDS yeaD NC_007606.1 1363381 1364286 R Code: G; COG: COG0676; hypothetical protein complement(1363381..1364286) Shigella dysenteriae Sd197 3798007 YP_403118.1 CDS gapA NC_007606.1 1364349 1365344 R Code: G; COG: COG0057; glyceraldehyde-3-phosphate dehydrogenase complement(1364349..1365344) Shigella dysenteriae Sd197 3797500 YP_403119.1 CDS yeaA NC_007606.1 1365686 1366099 D this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1365686..1366099 Shigella dysenteriae Sd197 3797501 YP_403120.1 CDS SDY_1490 NC_007606.1 1366096 1366413 D Code: S; COG: COG3139; hypothetical protein 1366096..1366413 Shigella dysenteriae Sd197 3797502 YP_403121.1 CDS SDY_1491 NC_007606.1 1366782 1367858 D Code: ER; COG: COG1063; oxidoreductase 1366782..1367858 Shigella dysenteriae Sd197 3797503 YP_403122.1 CDS SDY_1492 NC_007606.1 1367885 1369264 D Code: GEPR; COG: COG0477; transport protein 1367885..1369264 Shigella dysenteriae Sd197 3797504 YP_403123.1 CDS ydjJ NC_007606.1 1369320 1370327 D Code: ER; COG: COG1063; oxidoreductase 1369320..1370327 Shigella dysenteriae Sd197 3797505 YP_403124.1 CDS insA NC_007606.1 1370684 1370959 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(1370684..1370959) Shigella dysenteriae Sd197 3797506 YP_403125.1 CDS SDY_1495 NC_007606.1 1371015 1371659 D Code: G; COG: COG0524; kinase 1371015..1371659 Shigella dysenteriae Sd197 3797507 YP_403128.1 CDS SDY_1498 NC_007606.1 1372787 1373545 D Code: KG; COG: COG1349; DeoR-type transcriptional regulator 1372787..1373545 Shigella dysenteriae Sd197 3797510 YP_009000717.1 CDS SDY_1500a NC_007606.1 1374314 1374586 D insertion element iso-IS1N protein InsA 1374314..1374586 Shigella dysenteriae Sd197 18263031 YP_403130.1 CDS insA NC_007606.1 1375040 1375315 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1375040..1375315 Shigella dysenteriae Sd197 3797513 YP_403131.1 CDS insB NC_007606.1 1375360 1375737 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1375360..1375737 Shigella dysenteriae Sd197 3797514 YP_403132.1 CDS SDY_1503 NC_007606.1 1375960 1376355 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1375960..1376355) Shigella dysenteriae Sd197 3797515 YP_009000718.1 CDS SDY_1503a NC_007606.1 1376382 1376654 R insertion element iso-IS1N protein InsA complement(1376382..1376654) Shigella dysenteriae Sd197 18263032 YP_403134.2 CDS ydjB NC_007606.1 1377057 1377698 R catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase complement(1377057..1377698) Shigella dysenteriae Sd197 3797517 YP_403135.1 CDS ansA NC_007606.1 1377709 1378725 R converts asparagine to aspartate and ammonia; asparaginase complement(1377709..1378725) Shigella dysenteriae Sd197 3797518 YP_403136.1 CDS sppA NC_007606.1 1378879 1380735 R signal peptide peptidase; SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 complement(1378879..1380735) Shigella dysenteriae Sd197 3799324 YP_403137.1 CDS ydjA NC_007606.1 1380896 1381447 D Code: C; COG: COG0778; hypothetical protein 1380896..1381447 Shigella dysenteriae Sd197 3799325 YP_403138.1 CDS selD NC_007606.1 1381564 1382607 D H(2)Se added to acrylyl-tRNA; catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1381564..1382607 Shigella dysenteriae Sd197 3799326 YP_403139.1 CDS topB NC_007606.1 1382612 1384573 D decatenates replicating daughter chromosomes; DNA topoisomerase III 1382612..1384573 Shigella dysenteriae Sd197 3799327 YP_009000719.1 CDS SDY_1512a NC_007606.1 1384804 1385076 D insertion element iso-IS1N protein InsA 1384804..1385076 Shigella dysenteriae Sd197 18263033 YP_403141.1 CDS SDY_1512 NC_007606.1 1385351 1385746 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1385351..1385746) Shigella dysenteriae Sd197 3799329 YP_009000720.1 CDS SDY_1513a NC_007606.1 1385773 1386045 R insertion element iso-IS1N protein InsA complement(1385773..1386045) Shigella dysenteriae Sd197 18263034 YP_403142.2 CDS SDY_1513 NC_007606.1 1386335 1387288 D hypothetical protein 1386335..1387288 Shigella dysenteriae Sd197 3799330 YP_403143.1 CDS gdhA NC_007606.1 1387405 1388748 R converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase complement(1387405..1388748) Shigella dysenteriae Sd197 3799331 YP_403144.1 CDS SDY_1515 NC_007606.1 1388984 1389256 D hypothetical protein 1388984..1389256 Shigella dysenteriae Sd197 3799332 YP_403145.1 CDS SDY_1516 NC_007606.1 1389222 1389629 R Code: LR; COG: COG0494; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase complement(1389222..1389629) Shigella dysenteriae Sd197 3799333 YP_403147.1 CDS SDY_1519 NC_007606.1 1391718 1392371 R Code: R; COG: COG4136; ATPase complement(1391718..1392371) Shigella dysenteriae Sd197 3799336 YP_403151.1 CDS ynjA NC_007606.1 1395056 1395604 R Code: S; COG: COG2128; hypothetical protein complement(1395056..1395604) Shigella dysenteriae Sd197 3799340 YP_403152.1 CDS ydjZ NC_007606.1 1395604 1396311 R Code: S; COG: COG0398; hypothetical protein complement(1395604..1396311) Shigella dysenteriae Sd197 3799341 YP_403153.1 CDS ydjY NC_007606.1 1396326 1397003 R hypothetical protein complement(1396326..1397003) Shigella dysenteriae Sd197 3799342 YP_403154.1 CDS ydjX NC_007606.1 1397008 1397571 R Code: S; COG: COG0398; hypothetical protein complement(1397008..1397571) Shigella dysenteriae Sd197 3799343 YP_403155.1 CDS xthA NC_007606.1 1397738 1398544 R removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III complement(1397738..1398544) Shigella dysenteriae Sd197 3799016 YP_403156.1 CDS insA NC_007606.1 1400378 1400677 R Code: L; COG: COG3677; insertion element iso-IS1d protein InsA complement(1400378..1400677) Shigella dysenteriae Sd197 3799018 YP_403157.1 CDS SDY_1530 NC_007606.1 1400983 1402017 D Code: E; COG: COG3138; arginine succinyltransferase 1400983..1402017 Shigella dysenteriae Sd197 3799019 YP_403158.1 CDS SDY_1531 NC_007606.1 1402014 1403015 D Code: C; COG: COG1012; aldehyde dehydrogenase 1402014..1403015 Shigella dysenteriae Sd197 3799020 YP_403159.2 CDS SDY_1532 NC_007606.1 1403484 1404830 D ''catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation''; succinylarginine dihydrolase 1403484..1404830 Shigella dysenteriae Sd197 3799021 YP_403161.1 CDS spy NC_007606.1 1406110 1406595 D periplasmic protein related to spheroblast formation; periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; hypothetical protein 1406110..1406595 Shigella dysenteriae Sd197 3799023 YP_403162.1 CDS SDY_1535 NC_007606.1 1406798 1407073 D hypothetical protein 1406798..1407073 Shigella dysenteriae Sd197 3799024 YP_009000721.1 CDS SDY_1537a NC_007606.1 1407470 1407742 R insertion element iso-IS1N protein InsA complement(1407470..1407742) Shigella dysenteriae Sd197 18263035 YP_403166.1 CDS SDY_1539 NC_007606.1 1408108 1408974 R 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease complement(1408108..1408974) Shigella dysenteriae Sd197 3799028 YP_403167.1 CDS nadE NC_007606.1 1409204 1410031 R prefers NH3 over glutamine; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1409204..1410031) Shigella dysenteriae Sd197 3799029 YP_403168.1 CDS osmE NC_007606.1 1410233 1410571 D osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1410233..1410571 Shigella dysenteriae Sd197 3799030 YP_009000722.1 CDS SDY_1541a NC_007606.1 1410800 1411072 D insertion element iso-IS1N protein InsA 1410800..1411072 Shigella dysenteriae Sd197 18263036 YP_403169.1 CDS SDY_1542 NC_007606.1 1411099 1411494 D Code: L; COG: COG1662; insertion element IS1 protein InsB 1411099..1411494 Shigella dysenteriae Sd197 3799031 YP_403171.1 CDS insA NC_007606.1 1413278 1413553 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1413278..1413553 Shigella dysenteriae Sd197 3799033 YP_403172.1 CDS insB NC_007606.1 1413598 1413975 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1413598..1413975 Shigella dysenteriae Sd197 3799034 YP_403173.1 CDS ydgC NC_007606.1 1414088 1414423 D Code: R; COG: COG3136; hypothetical protein 1414088..1414423 Shigella dysenteriae Sd197 3796423 YP_403174.1 CDS ydgB NC_007606.1 1414420 1415142 R Code: IQR; COG: COG1028; short chain dehydrogenase complement(1414420..1415142) Shigella dysenteriae Sd197 3796424 YP_403175.1 CDS SDY_1548 NC_007606.1 1415179 1416561 R Code: E; COG: COG0531; arginine/ornithine antiporter complement(1415179..1416561) Shigella dysenteriae Sd197 3796425 YP_403176.1 CDS SDY_1549 NC_007606.1 1416747 1417691 R hypothetical protein complement(1416747..1417691) Shigella dysenteriae Sd197 3796426 YP_403177.1 CDS pntA NC_007606.1 1418215 1419747 D forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1418215..1419747 Shigella dysenteriae Sd197 3796427 YP_403178.1 CDS pntB NC_007606.1 1419758 1421146 D catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1419758..1421146 Shigella dysenteriae Sd197 3796428 YP_403179.1 CDS tqsA NC_007606.1 1421171 1422205 R transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transport protein complement(1421171..1422205) Shigella dysenteriae Sd197 3796429 YP_403180.1 CDS SDY_1553 NC_007606.1 1422617 1422982 D ''with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS''; multidrug efflux system protein MdtJ 1422617..1422982 Shigella dysenteriae Sd197 3796430 YP_403181.1 CDS SDY_1554 NC_007606.1 1422969 1423298 D ''with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS''; multidrug efflux system protein MdtI 1422969..1423298 Shigella dysenteriae Sd197 3796431 YP_403182.1 CDS SDY_1555 NC_007606.1 1423337 1424158 R Code: E; COG: COG3591; hypothetical protein complement(1423337..1424158) Shigella dysenteriae Sd197 3796432 YP_403183.2 CDS asr NC_007606.1 1424434 1424742 R required for growth and survival under moderately acid conditions; acid shock protein complement(1424434..1424742) Shigella dysenteriae Sd197 3796433 YP_009000723.1 CDS SDY_1556a NC_007606.1 1425129 1425401 D insertion element iso-IS1N protein InsA 1425129..1425401 Shigella dysenteriae Sd197 18263037 YP_403187.1 CDS insB NC_007606.1 1427626 1428003 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1427626..1428003 Shigella dysenteriae Sd197 3796437 YP_403188.1 CDS ynfL NC_007606.1 1428076 1428969 D Code: K; COG: COG0583; LysR family transcriptional regulator 1428076..1428969 Shigella dysenteriae Sd197 3796438 YP_403189.1 CDS mlc NC_007606.1 1429104 1430324 D Code: KG; COG: COG1940; NAGC-like transcriptional regulator 1429104..1430324 Shigella dysenteriae Sd197 3796439 YP_403190.2 CDS SDY_1563 NC_007606.1 1430449 1431144 D ''DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium''; dithiobiotin synthetase 1430449..1431144 Shigella dysenteriae Sd197 3796440 YP_403191.1 CDS SDY_1564 NC_007606.1 1431097 1432434 R Code: P; COG: COG0038; voltage-gated ClC-type chloride channel ClcB complement(1431097..1432434) Shigella dysenteriae Sd197 3796441 YP_403192.1 CDS SDY_1566 NC_007606.1 1433204 1434058 R Code: R; COG: COG3302; DMSO reductase anchor subunit complement(1433204..1434058) Shigella dysenteriae Sd197 3797106 YP_403193.1 CDS SDY_1567 NC_007606.1 1434060 1434677 R Code: C; COG: COG0437; oxidoreductase Fe-S subunit complement(1434060..1434677) Shigella dysenteriae Sd197 3797107 YP_403194.1 CDS SDY_1570 NC_007606.1 1439771 1440118 R hypothetical protein complement(1439771..1440118) Shigella dysenteriae Sd197 3797110 YP_403195.2 CDS ynfC NC_007606.1 1440184 1440894 D hypothetical protein 1440184..1440894 Shigella dysenteriae Sd197 3797111 YP_403196.1 CDS SDY_1572 NC_007606.1 1440894 1441106 D hypothetical protein 1440894..1441106 Shigella dysenteriae Sd197 3797112 YP_009000724.1 CDS SDY_1572a NC_007606.1 1441142 1441414 D insertion element iso-IS1N protein InsA 1441142..1441414 Shigella dysenteriae Sd197 18263038 YP_403198.1 CDS SDY_1574 NC_007606.1 1441441 1441836 D Code: L; COG: COG1662; insertion element IS1 protein InsB 1441441..1441836 Shigella dysenteriae Sd197 3797114 YP_403199.1 CDS SDY_1576 NC_007606.1 1442266 1442607 R hypothetical protein complement(1442266..1442607) Shigella dysenteriae Sd197 3797116 YP_403200.1 CDS SDY_1577 NC_007606.1 1442742 1443068 D Code: S; COG: COG1742; hypothetical protein 1442742..1443068 Shigella dysenteriae Sd197 3797117 YP_403201.1 CDS SDY_1580 NC_007606.1 1445214 1445609 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1445214..1445609) Shigella dysenteriae Sd197 3797120 YP_009000725.1 CDS SDY_1580a NC_007606.1 1445636 1445908 R insertion element iso-IS1N protein InsA complement(1445636..1445908) Shigella dysenteriae Sd197 18263039 YP_403203.1 CDS SDY_1582 NC_007606.1 1446435 1447718 D Code: GEPR; COG: COG0477; transport protein 1446435..1447718 Shigella dysenteriae Sd197 3797122 YP_403204.1 CDS SDY_1584 NC_007606.1 1449303 1449506 R hypothetical protein complement(1449303..1449506) Shigella dysenteriae Sd197 3797124 YP_403205.1 CDS ydfH NC_007606.1 1449683 1450369 R Code: K; COG: COG1802; hypothetical protein complement(1449683..1450369) Shigella dysenteriae Sd197 3796899 YP_403206.1 CDS ydfG NC_007606.1 1450458 1451204 R ''NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine''; 3-hydroxy acid dehydrogenase complement(1450458..1451204) Shigella dysenteriae Sd197 3796900 YP_403207.1 CDS dcp NC_007606.1 1451341 1453386 D Code: E; COG: COG0339; dipeptidyl carboxypeptidase II 1451341..1453386 Shigella dysenteriae Sd197 3796901 YP_403208.1 CDS ydeJ NC_007606.1 1453431 1453949 R Code: R; COG: COG1546; competence damage-inducible protein A complement(1453431..1453949) Shigella dysenteriae Sd197 3796902 YP_403209.1 CDS ydeI NC_007606.1 1454225 1454617 D Code: S; COG: COG3111; hypothetical protein 1454225..1454617 Shigella dysenteriae Sd197 3796903 YP_403210.1 CDS ydeH NC_007606.1 1454872 1455762 D Code: T; COG: COG2199; hypothetical protein 1454872..1455762 Shigella dysenteriae Sd197 3796904 YP_403211.1 CDS insA NC_007606.1 1456170 1456445 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1456170..1456445 Shigella dysenteriae Sd197 3796905 YP_403212.1 CDS insB NC_007606.1 1456490 1456867 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1456490..1456867 Shigella dysenteriae Sd197 3796906 YP_403213.1 CDS ydeF NC_007606.1 1456979 1458166 R YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; MFS-type transporter YdeE complement(1456979..1458166) Shigella dysenteriae Sd197 3796907 YP_403214.2 CDS ydeD NC_007606.1 1458361 1459260 D Code: GER; COG: COG0697; O-acetylserine/cysteine export protein 1458361..1459260 Shigella dysenteriae Sd197 3796908 YP_403215.2 CDS marA NC_007606.1 1459540 1459923 R multiple antibiotic resistance; transcriptional activator of defense systems; ''transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF''; DNA-binding transcriptional activator MarA complement(1459540..1459923) Shigella dysenteriae Sd197 3796910 YP_403216.2 CDS marR NC_007606.1 1459943 1460377 R multiple antibiotic resistance protein; repressor of mar operon; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR complement(1459943..1460377) Shigella dysenteriae Sd197 3796911 YP_403217.1 CDS ydeB NC_007606.1 1460589 1461254 D ''protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function''; multiple drug resistance protein MarC 1460589..1461254 Shigella dysenteriae Sd197 3796912 YP_403218.1 CDS ydeA NC_007606.1 1461279 1462337 R Code: G; COG: COG2814; sugar efflux transporter complement(1461279..1462337) Shigella dysenteriae Sd197 3796913 YP_009000726.1 CDS SDY_1599a NC_007606.1 1462519 1462791 D insertion element iso-IS1N protein InsA 1462519..1462791 Shigella dysenteriae Sd197 18263040 YP_403220.1 CDS SDY_1601 NC_007606.1 1462818 1463213 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1462818..1463213 Shigella dysenteriae Sd197 3796915 YP_403222.1 CDS yddG NC_007606.1 1463784 1464665 R Code: GER; COG: COG0697; hypothetical protein complement(1463784..1464665) Shigella dysenteriae Sd197 3796917 YP_403223.1 CDS fdnH NC_007606.1 1467969 1468853 D Code: C; COG: COG0437; formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit 1467969..1468853 Shigella dysenteriae Sd197 3796578 YP_403224.1 CDS fdnI NC_007606.1 1468846 1469499 D ''nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase''; formate dehydrogenase-N subunit gamma 1468846..1469499 Shigella dysenteriae Sd197 3796579 YP_403225.1 CDS yddM NC_007606.1 1469727 1470089 R Code: R; COG: COG3093; hypothetical protein complement(1469727..1470089) Shigella dysenteriae Sd197 3796580 YP_403226.2 CDS adhP NC_007606.1 1470071 1471168 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(1470071..1471168) Shigella dysenteriae Sd197 3796581 YP_403227.1 CDS osmC NC_007606.1 1472720 1473151 D Code: O; COG: COG1764; osmotically inducible protein 1472720..1473151 Shigella dysenteriae Sd197 3796583 YP_403228.1 CDS SDY_1611 NC_007606.1 1473207 1474133 R Code: EP; COG: COG1124; ATPase complement(1473207..1474133) Shigella dysenteriae Sd197 3796584 YP_403229.1 CDS SDY_1613 NC_007606.1 1475496 1476815 R Code: S; COG: COG1649; hypothetical protein complement(1475496..1476815) Shigella dysenteriae Sd197 3796586 YP_403230.1 CDS xasA NC_007606.1 1476946 1478481 R Code: E; COG: COG0531; acid sensitivity protein complement(1476946..1478481) Shigella dysenteriae Sd197 3796587 YP_403231.1 CDS gadB NC_007606.1 1478637 1480037 R Code: E; COG: COG0076; glutamate decarboxylase complement(1478637..1480037) Shigella dysenteriae Sd197 3796588 YP_403234.1 CDS SDY_1618 NC_007606.1 1481079 1481507 D hypothetical protein 1481079..1481507 Shigella dysenteriae Sd197 3796591 YP_403236.1 CDS insA NC_007606.1 1482640 1482915 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1482640..1482915 Shigella dysenteriae Sd197 3796593 YP_009000727.1 CDS SDY_1622a NC_007606.1 1483479 1483706 D insertion element iso-IS1N protein InsA 1483479..1483706 Shigella dysenteriae Sd197 18263041 YP_403239.1 CDS yneB NC_007606.1 1484106 1484918 D Code: G; COG: COG1830; aldolase 1484106..1484918 Shigella dysenteriae Sd197 3796596 YP_403240.1 CDS SDY_1624 NC_007606.1 1484942 1485232 D Code: S; COG: COG1359; autoinducer-2 (AI-2) modifying protein LsrG 1484942..1485232 Shigella dysenteriae Sd197 3795944 YP_403241.1 CDS SDY_1625 NC_007606.1 1485289 1486047 D catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1485289..1486047 Shigella dysenteriae Sd197 3795945 YP_403244.1 CDS SDY_1629 NC_007606.1 1488678 1490177 R Code: T; COG: COG2199; hypothetical protein complement(1488678..1490177) Shigella dysenteriae Sd197 3795949 YP_403245.1 CDS SDY_1630 NC_007606.1 1490316 1490675 R hypothetical protein complement(1490316..1490675) Shigella dysenteriae Sd197 3795950 YP_403246.1 CDS yneH NC_007606.1 1490675 1491601 R catalyzes the formation of glutamate from glutamine; glutaminase complement(1490675..1491601) Shigella dysenteriae Sd197 3795951 YP_403247.1 CDS SDY_1632 NC_007606.1 1491665 1493077 R in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; succinate-semialdehyde dehydrogenase complement(1491665..1493077) Shigella dysenteriae Sd197 3795952 YP_403248.1 CDS yneJ NC_007606.1 1493154 1494035 D Code: K; COG: COG0583; LysR family transcriptional regulator 1493154..1494035 Shigella dysenteriae Sd197 3795953 YP_403249.1 CDS SDY_1634 NC_007606.1 1494113 1494754 D hypothetical protein 1494113..1494754 Shigella dysenteriae Sd197 3795954 YP_403250.1 CDS SDY_1635 NC_007606.1 1494751 1495146 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1494751..1495146) Shigella dysenteriae Sd197 3795955 YP_403251.1 CDS SDY_1636 NC_007606.1 1495597 1496088 D hypothetical protein 1495597..1496088 Shigella dysenteriae Sd197 3795956 YP_403252.1 CDS ymjA NC_007606.1 1496222 1496467 D hypothetical protein 1496222..1496467 Shigella dysenteriae Sd197 3795957 YP_403253.1 CDS sapA NC_007606.1 1496780 1498423 D Code: E; COG: COG4166; protein SapA 1496780..1498423 Shigella dysenteriae Sd197 3795958 YP_403254.1 CDS sapB NC_007606.1 1498420 1499385 D Code: V; COG: COG4168; hypothetical protein 1498420..1499385 Shigella dysenteriae Sd197 3795959 YP_403259.1 CDS SDY_1644 NC_007606.1 1506137 1506439 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1506137..1506439 Shigella dysenteriae Sd197 3795847 YP_403260.2 CDS SDY_1645 NC_007606.1 1506830 1507735 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(1506830..1507735) Shigella dysenteriae Sd197 3795848 YP_403261.1 CDS SDY_1646 NC_007606.1 1507693 1508058 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(1507693..1508058) Shigella dysenteriae Sd197 3795849 YP_403264.1 CDS narY NC_007606.1 1513880 1515403 D Code: C; COG: COG1140; cryptic nitrate reductase 2 subunit beta 1513880..1515403 Shigella dysenteriae Sd197 3795854 YP_403265.1 CDS narW NC_007606.1 1515403 1516098 D Code: C; COG: COG2180; cryptic nitrate reductase 2 subunit delta 1515403..1516098 Shigella dysenteriae Sd197 3795855 YP_403266.1 CDS narV NC_007606.1 1516095 1516775 D Code: C; COG: COG2181; cryptic nitrate reductase 2 subunit gamma 1516095..1516775 Shigella dysenteriae Sd197 3795856 YP_403267.1 CDS yddE NC_007606.1 1516855 1517748 D Code: R; COG: COG0384; hypothetical protein 1516855..1517748 Shigella dysenteriae Sd197 3795857 YP_009000728.1 CDS SDY_1654a NC_007606.1 1518522 1518794 D insertion element iso-IS1N protein InsA 1518522..1518794 Shigella dysenteriae Sd197 18263042 YP_403269.1 CDS SDY_1657 NC_007606.1 1519195 1519872 D adhesin 1519195..1519872 Shigella dysenteriae Sd197 3795860 YP_403270.1 CDS SDY_1658 NC_007606.1 1520206 1522485 D in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase; oxidoreductase 1520206..1522485 Shigella dysenteriae Sd197 3795861 YP_403271.1 CDS SDY_1659 NC_007606.1 1522734 1522931 D hypothetical protein 1522734..1522931 Shigella dysenteriae Sd197 3795862 YP_403272.1 CDS SDY_1660 NC_007606.1 1523006 1523785 D regulates the cellular response to acid resistance; transcriptional regulator YdeO 1523006..1523785 Shigella dysenteriae Sd197 3795863 YP_403273.1 CDS SDY_1661 NC_007606.1 1524172 1524657 D hypothetical protein 1524172..1524657 Shigella dysenteriae Sd197 3795864 YP_403274.1 CDS SDY_1662 NC_007606.1 1524905 1525300 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1524905..1525300) Shigella dysenteriae Sd197 3795865 YP_009000729.1 CDS SDY_1661a NC_007606.1 1525327 1525599 R insertion element iso-IS1N protein InsA complement(1525327..1525599) Shigella dysenteriae Sd197 18263043 YP_403275.1 CDS SDY_1663 NC_007606.1 1525712 1526020 D hypothetical protein 1525712..1526020 Shigella dysenteriae Sd197 3796227 YP_009000730.1 CDS SDY_1667a NC_007606.1 1528216 1528488 D insertion element iso-IS1N protein InsA 1528216..1528488 Shigella dysenteriae Sd197 18263044 YP_403279.1 CDS SDY_1667 NC_007606.1 1528515 1528910 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1528515..1528910 Shigella dysenteriae Sd197 3796231 YP_403280.1 CDS SDY_1668 NC_007606.1 1529017 1529355 D hypothetical protein 1529017..1529355 Shigella dysenteriae Sd197 3796232 YP_403281.1 CDS SDY_1669 NC_007606.1 1529522 1531258 R hypothetical protein complement(1529522..1531258) Shigella dysenteriae Sd197 3796233 YP_403282.1 CDS SDY_1670 NC_007606.1 1531311 1532576 R hypothetical protein complement(1531311..1532576) Shigella dysenteriae Sd197 3796234 YP_403284.1 CDS SDY_1672 NC_007606.1 1533550 1533852 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(1533550..1533852) Shigella dysenteriae Sd197 3796236 YP_403285.1 CDS SDY_1673 NC_007606.1 1534354 1534623 R hypothetical protein complement(1534354..1534623) Shigella dysenteriae Sd197 3796237 YP_403286.1 CDS SDY_1674 NC_007606.1 1534642 1535052 R Code: Q; COG: COG2050; hypothetical protein complement(1534642..1535052) Shigella dysenteriae Sd197 3796238 YP_403287.1 CDS ydiJ NC_007606.1 1535049 1538105 R Code: C; COG: COG0277; oxidase complement(1535049..1538105) Shigella dysenteriae Sd197 3796239 YP_403288.1 CDS SDY_1676 NC_007606.1 1538494 1539606 D ''YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function''; inner membrane protein 1538494..1539606 Shigella dysenteriae Sd197 3796240 YP_403290.1 CDS SDY_1678 NC_007606.1 1540892 1541194 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(1540892..1541194) Shigella dysenteriae Sd197 3796242 YP_403291.1 CDS SDY_1679 NC_007606.1 1541277 1541660 D hypothetical protein 1541277..1541660 Shigella dysenteriae Sd197 3796243 YP_403292.1 CDS SDY_1680 NC_007606.1 1541787 1542182 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1541787..1542182) Shigella dysenteriae Sd197 3796244 YP_009000731.1 CDS SDY_1682a NC_007606.1 1542209 1542481 R insertion element iso-IS1N protein InsA complement(1542209..1542481) Shigella dysenteriae Sd197 18263045 YP_403294.1 CDS SDY_1682 NC_007606.1 1542606 1542986 D hypothetical protein 1542606..1542986 Shigella dysenteriae Sd197 3796246 YP_009000732.1 CDS SDY_1682b NC_007606.1 1543026 1543298 D insertion element iso-IS1N protein InsA 1543026..1543298 Shigella dysenteriae Sd197 18263046 YP_403296.1 CDS SDY_1684 NC_007606.1 1543799 1544161 D Code: T; COG: COG2199; hypothetical protein 1543799..1544161 Shigella dysenteriae Sd197 3796248 YP_403297.1 CDS yeaK NC_007606.1 1544204 1544707 D Code: S; COG: COG2606; hypothetical protein 1544204..1544707 Shigella dysenteriae Sd197 3796249 YP_403298.1 CDS SDY_1686 NC_007606.1 1544708 1544860 R hypothetical protein complement(1544708..1544860) Shigella dysenteriae Sd197 3796250 YP_403299.1 CDS yeaL NC_007606.1 1544982 1545428 D Code: S; COG: COG2707; hypothetical protein 1544982..1545428 Shigella dysenteriae Sd197 3796251 YP_403300.1 CDS yeaM NC_007606.1 1545385 1546206 R Code: K; COG: COG2207; AraC family transcriptional regulator complement(1545385..1546206) Shigella dysenteriae Sd197 3796252 YP_403301.1 CDS yeaN NC_007606.1 1546303 1547484 D Code: P; COG: COG2807; amino acid/amine transport protein 1546303..1547484 Shigella dysenteriae Sd197 3796253 YP_403302.1 CDS yeaO NC_007606.1 1547518 1547886 D Code: S; COG: COG3189; hypothetical protein 1547518..1547886 Shigella dysenteriae Sd197 3796254 YP_403303.1 CDS yoaF NC_007606.1 1547908 1548162 R Code: R; COG: COG3042; hypothetical protein complement(1547908..1548162) Shigella dysenteriae Sd197 3796255 YP_403304.1 CDS yeaP NC_007606.1 1548216 1549370 D Code: T; COG: COG2203; hypothetical protein 1548216..1549370 Shigella dysenteriae Sd197 3796256 YP_403305.2 CDS SDY_1693 NC_007606.1 1549529 1549924 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1549529..1549924) Shigella dysenteriae Sd197 3796257 YP_009000733.1 CDS SDY_1695a NC_007606.1 1549951 1550223 R insertion element iso-IS1N protein InsA complement(1549951..1550223) Shigella dysenteriae Sd197 18263047 YP_403307.1 CDS yeaQ NC_007606.1 1550411 1550659 R Code: S; COG: COG2261; hypothetical protein complement(1550411..1550659) Shigella dysenteriae Sd197 3796259 YP_403308.1 CDS yoaG NC_007606.1 1550807 1550989 R hypothetical protein complement(1550807..1550989) Shigella dysenteriae Sd197 3796260 YP_403309.1 CDS yeaR NC_007606.1 1550993 1551352 R Code: P; COG: COG3615; hypothetical protein complement(1550993..1551352) Shigella dysenteriae Sd197 3796261 YP_403310.1 CDS yeaS NC_007606.1 1551525 1552163 R Code: E; COG: COG1280; leucine export protein LeuE complement(1551525..1552163) Shigella dysenteriae Sd197 3796262 YP_403311.1 CDS SDY_1699 NC_007606.1 1552263 1552658 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1552263..1552658) Shigella dysenteriae Sd197 3796263 YP_009000734.1 CDS SDY_1699a NC_007606.1 1552686 1552958 R insertion element iso-IS1N protein InsA complement(1552686..1552958) Shigella dysenteriae Sd197 18263048 YP_403312.1 CDS yeaT NC_007606.1 1553027 1553971 R Code: K; COG: COG0583; LysR family transcriptional regulator complement(1553027..1553971) Shigella dysenteriae Sd197 3796264 YP_403313.1 CDS yeaU NC_007606.1 1554053 1555138 D Code: CE; COG: COG0473; tartrate dehydrogenase 1554053..1555138 Shigella dysenteriae Sd197 3796265 YP_403314.1 CDS SDY_1702 NC_007606.1 1555389 1555604 D hypothetical protein 1555389..1555604 Shigella dysenteriae Sd197 3796266 YP_403316.1 CDS SDY_1704 NC_007606.1 1555926 1556321 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1555926..1556321 Shigella dysenteriae Sd197 3796268 YP_403317.1 CDS yeaW NC_007606.1 1557775 1558899 D Code: PR; COG: COG4638; hypothetical protein 1557775..1558899 Shigella dysenteriae Sd197 3796270 YP_403318.1 CDS yeaX NC_007606.1 1558955 1559920 D Code: C; COG: COG1018; diogenase subunit beta 1558955..1559920 Shigella dysenteriae Sd197 3796271 YP_403319.1 CDS rnd NC_007606.1 1559974 1561101 R processes tRNA precursor; Code: J; COG: COG0349; ribonuclease D complement(1559974..1561101) Shigella dysenteriae Sd197 3796272 YP_403320.1 CDS fadD NC_007606.1 1561171 1562856 R Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(1561171..1562856) Shigella dysenteriae Sd197 3796273 YP_403321.1 CDS SDY_1710 NC_007606.1 1563061 1563642 R Code: M; COG: COG3065; outer membrane protein complement(1563061..1563642) Shigella dysenteriae Sd197 3796274 YP_403322.1 CDS yeaZ NC_007606.1 1563682 1564377 R Code: O; COG: COG1214; hypothetical protein complement(1563682..1564377) Shigella dysenteriae Sd197 3796275 YP_403323.1 CDS SDY_1712 NC_007606.1 1564435 1566345 R Code: KL; COG: COG1199; DNA helicase complement(1564435..1566345) Shigella dysenteriae Sd197 3796276 YP_403324.1 CDS SDY_1713 NC_007606.1 1566429 1566821 D Code: J; COG: COG0251; hypothetical protein 1566429..1566821 Shigella dysenteriae Sd197 3796277 YP_403325.1 CDS insA NC_007606.1 1567023 1567298 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1567023..1567298 Shigella dysenteriae Sd197 3796278 YP_403326.1 CDS insB NC_007606.1 1567343 1567720 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1567343..1567720 Shigella dysenteriae Sd197 3796279 YP_403328.1 CDS SDY_1717 NC_007606.1 1568439 1568618 R Code: S; COG: COG3140; hypothetical protein complement(1568439..1568618) Shigella dysenteriae Sd197 3796281 YP_403329.1 CDS pabB NC_007606.1 1568692 1570053 D Code: EH; COG: COG0147; para-aminobenzoate synthase component I 1568692..1570053 Shigella dysenteriae Sd197 3796282 YP_403330.1 CDS yeaB NC_007606.1 1570057 1570635 D Code: LR; COG: COG0494; hypothetical protein 1570057..1570635 Shigella dysenteriae Sd197 3796283 YP_403331.1 CDS sdaA NC_007606.1 1570819 1572183 D Code: E; COG: COG1760; L-serine deaminase 1570819..1572183 Shigella dysenteriae Sd197 3796284 YP_403332.1 CDS insA NC_007606.1 1572553 1572828 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1572553..1572828 Shigella dysenteriae Sd197 3796285 YP_403333.1 CDS insB NC_007606.1 1572873 1573250 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1572873..1573250 Shigella dysenteriae Sd197 3796286 YP_403334.1 CDS SDY_1723 NC_007606.1 1573185 1573496 R hypothetical protein complement(1573185..1573496) Shigella dysenteriae Sd197 3796287 YP_403335.1 CDS yncB NC_007606.1 1573694 1574824 R Code: R; COG: COG2130; oxidoreductase complement(1573694..1574824) Shigella dysenteriae Sd197 3796288 YP_403336.1 CDS SDY_1725 NC_007606.1 1574909 1575427 D Code: M; COG: COG1247; resistance protein 1574909..1575427 Shigella dysenteriae Sd197 3796289 YP_403337.1 CDS SDY_1726 NC_007606.1 1575424 1575873 D Code: S; COG: COG3238; hypothetical protein 1575424..1575873 Shigella dysenteriae Sd197 3796290 YP_403338.1 CDS SDY_1727 NC_007606.1 1576053 1576448 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1576053..1576448) Shigella dysenteriae Sd197 3796291 YP_009000735.1 CDS SDY_4665 NC_007606.1 1576475 1576747 R insertion element iso-IS1N protein InsA complement(1576475..1576747) Shigella dysenteriae Sd197 18263049 YP_403340.2 CDS SDY_1729 NC_007606.1 1576967 1577140 R hypothetical protein complement(1576967..1577140) Shigella dysenteriae Sd197 3796293 YP_403341.1 CDS SDY_1730 NC_007606.1 1577527 1578951 R catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase complement(1577527..1578951) Shigella dysenteriae Sd197 3796294 YP_403342.1 CDS SDY_1733 NC_007606.1 1580610 1581623 R Code: E; COG: COG3842; ATPase complement(1580610..1581623) Shigella dysenteriae Sd197 3796297 YP_403343.1 CDS SDY_1734 NC_007606.1 1581641 1582786 R Code: E; COG: COG0687; transport protein complement(1581641..1582786) Shigella dysenteriae Sd197 3796298 YP_403344.1 CDS SDY_1735 NC_007606.1 1583031 1584437 R multi modular; also ATP-binding component of a transport system; Code: KE; COG: COG1167; transcriptional regulator complement(1583031..1584437) Shigella dysenteriae Sd197 3796299 YP_403345.1 CDS SDY_1736 NC_007606.1 1584516 1584953 R Code: S; COG: COG1598; hypothetical protein complement(1584516..1584953) Shigella dysenteriae Sd197 3796300 YP_403347.1 CDS SDY_1738 NC_007606.1 1585246 1585641 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1585246..1585641) Shigella dysenteriae Sd197 3796302 YP_009000736.1 CDS SDY_4666 NC_007606.1 1585668 1585940 R insertion element iso-IS1N protein InsA complement(1585668..1585940) Shigella dysenteriae Sd197 18263050 YP_403349.1 CDS ydcP NC_007606.1 1586198 1587835 R Code: O; COG: COG0826; collagenase complement(1586198..1587835) Shigella dysenteriae Sd197 3796304 YP_403350.1 CDS ydcN NC_007606.1 1587866 1588402 R Code: K; COG: COG1396; hypothetical protein complement(1587866..1588402) Shigella dysenteriae Sd197 3796306 YP_403352.1 CDS insB NC_007606.1 1589902 1590279 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(1589902..1590279) Shigella dysenteriae Sd197 3796308 YP_403353.1 CDS insA NC_007606.1 1590324 1590599 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(1590324..1590599) Shigella dysenteriae Sd197 3796309 YP_403354.1 CDS SDY_1746 NC_007606.1 1590628 1590966 R hypothetical protein complement(1590628..1590966) Shigella dysenteriae Sd197 3796310 YP_403355.1 CDS tehB NC_007606.1 1591269 1591862 R with TehA confers resistance to tellurite; tellurite resistance protein TehB complement(1591269..1591862) Shigella dysenteriae Sd197 3796311 YP_403356.1 CDS tehA NC_007606.1 1591859 1592839 R Code: P; COG: COG1275; potassium-tellurite ethidium and proflavin transporter complement(1591859..1592839) Shigella dysenteriae Sd197 3796312 YP_403359.1 CDS rimL NC_007606.1 1593936 1594475 R acetylation of N-terminal serine of 30S ribosomal subunit protein L7; Code: J; COG: COG1670; ribosomal-protein-L7/L12-serine acetyltransferase complement(1593936..1594475) Shigella dysenteriae Sd197 3796315 YP_403360.1 CDS ydcH NC_007606.1 1594538 1594705 R Code: S; COG: COG2841; hypothetical protein complement(1594538..1594705) Shigella dysenteriae Sd197 3796316 YP_403361.1 CDS insA NC_007606.1 1594803 1595078 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1594803..1595078 Shigella dysenteriae Sd197 3796317 YP_403362.1 CDS insB NC_007606.1 1595123 1595500 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1595123..1595500 Shigella dysenteriae Sd197 3796318 YP_403364.1 CDS mdoD NC_007606.1 1595679 1597334 R involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D complement(1595679..1597334) Shigella dysenteriae Sd197 3796320 YP_403365.1 CDS SDY_1757 NC_007606.1 1597559 1598902 R Code: S; COG: COG5383; hypothetical protein complement(1597559..1598902) Shigella dysenteriae Sd197 3796321 YP_403366.1 CDS SDY_1758 NC_007606.1 1598978 1600033 D Code: K; COG: COG0583; LysR family transcriptional regulator 1598978..1600033 Shigella dysenteriae Sd197 3796322 YP_009000737.1 CDS SDY_4667 NC_007606.1 1600069 1600341 D insertion element iso-IS1N protein InsA 1600069..1600341 Shigella dysenteriae Sd197 18263051 YP_403367.1 CDS SDY_1759 NC_007606.1 1600368 1600763 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1600368..1600763 Shigella dysenteriae Sd197 3796323 YP_403368.1 CDS trg NC_007606.1 1600836 1602269 R ribose sensor receptor; Code: NT; COG: COG0840; methyl-accepting chemotaxis protein III complement(1600836..1602269) Shigella dysenteriae Sd197 3796324 YP_403369.1 CDS SDY_1761 NC_007606.1 1602320 1602715 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1602320..1602715) Shigella dysenteriae Sd197 3796325 YP_009000738.1 CDS SDY_4668 NC_007606.1 1602742 1603014 R insertion element iso-IS1N protein InsA complement(1602742..1603014) Shigella dysenteriae Sd197 18263052 YP_403370.1 CDS SDY_1762 NC_007606.1 1603591 1603758 D hypothetical protein 1603591..1603758 Shigella dysenteriae Sd197 3796326 YP_403371.1 CDS ydcA NC_007606.1 1603870 1604043 R hypothetical protein complement(1603870..1604043) Shigella dysenteriae Sd197 3796327 YP_403372.2 CDS cybB NC_007606.1 1604288 1604818 R B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 complement(1604288..1604818) Shigella dysenteriae Sd197 3796328 YP_403374.1 CDS SDY_1768 NC_007606.1 1607962 1608264 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(1607962..1608264) Shigella dysenteriae Sd197 3796332 YP_403375.1 CDS SDY_1769 NC_007606.1 1609012 1609227 R insertion element iso-IS1n protein InsB complement(1609012..1609227) Shigella dysenteriae Sd197 3796333 YP_009000739.1 CDS SDY_4669 NC_007606.1 1609434 1609706 R insertion element iso-IS1N protein InsA complement(1609434..1609706) Shigella dysenteriae Sd197 18263053 YP_403376.1 CDS SDY_1770 NC_007606.1 1609746 1610159 R hypothetical protein complement(1609746..1610159) Shigella dysenteriae Sd197 3796334 YP_403377.1 CDS insA NC_007606.1 1610390 1610665 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1610390..1610665 Shigella dysenteriae Sd197 3796335 YP_403378.1 CDS insB NC_007606.1 1610710 1611087 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1610710..1611087 Shigella dysenteriae Sd197 3796336 YP_403380.1 CDS hrpA NC_007606.1 1611837 1615682 R ''involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain''; ATP-dependent RNA helicase HrpA complement(1611837..1615682) Shigella dysenteriae Sd197 3796338 YP_403381.1 CDS acpD NC_007606.1 1615940 1616545 D FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1615940..1616545 Shigella dysenteriae Sd197 3796339 YP_403382.1 CDS ynbD NC_007606.1 1616599 1617624 R Code: I; COG: COG0671; protein YnbD complement(1616599..1617624) Shigella dysenteriae Sd197 3796340 YP_403383.1 CDS SDY_1777 NC_007606.1 1617624 1617860 R hypothetical protein complement(1617624..1617860) Shigella dysenteriae Sd197 3796341 YP_009000740.1 CDS SDY_4670 NC_007606.1 1617756 1618028 D insertion element iso-IS1N protein InsA 1617756..1618028 Shigella dysenteriae Sd197 18263054 YP_403384.1 CDS SDY_1778 NC_007606.1 1618055 1618450 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1618055..1618450 Shigella dysenteriae Sd197 3796342 YP_403385.1 CDS SDY_1779 NC_007606.1 1618679 1620436 R Code: QR; COG: COG0500; hypothetical protein complement(1618679..1620436) Shigella dysenteriae Sd197 3796343 YP_009000741.1 CDS SDY_4671 NC_007606.1 1621773 1622045 R insertion element iso-IS1N protein InsA complement(1621773..1622045) Shigella dysenteriae Sd197 18263055 YP_403388.2 CDS SDY_1783 NC_007606.1 1622393 1623544 D may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; acyl-CoA dehydrogenase 1622393..1623544 Shigella dysenteriae Sd197 3796191 YP_403389.1 CDS SDY_1784 NC_007606.1 1623587 1624720 R Code: L; COG: COG2801; fused IS600 integrase core domain-containing protein/HTH-type transcriptional regulator complement(1623587..1624720) Shigella dysenteriae Sd197 3796192 YP_403390.1 CDS SDY_1785 NC_007606.1 1624861 1625163 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(1624861..1625163) Shigella dysenteriae Sd197 3796193 YP_403391.1 CDS SDY_1786 NC_007606.1 1625225 1625767 R Code: K; COG: COG2207; AraC family transcriptional regulator complement(1625225..1625767) Shigella dysenteriae Sd197 3796194 YP_403393.1 CDS SDY_1789 NC_007606.1 1627486 1627788 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(1627486..1627788) Shigella dysenteriae Sd197 3796197 YP_403394.1 CDS ydiS NC_007606.1 1629127 1630416 D flavoprotein; probably electron transport; Code: C; COG: COG0644; hypothetical protein 1629127..1630416 Shigella dysenteriae Sd197 3796199 YP_403395.1 CDS ydiT NC_007606.1 1630413 1630706 D Code: C; COG: COG2440; hypothetical protein 1630413..1630706 Shigella dysenteriae Sd197 3796200 YP_403396.1 CDS ppsA NC_007606.1 1632467 1634845 R catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase complement(1632467..1634845) Shigella dysenteriae Sd197 3796202 YP_403397.1 CDS SDY_1795 NC_007606.1 1635073 1635438 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 1635073..1635438 Shigella dysenteriae Sd197 3796203 YP_403399.1 CDS ydiA NC_007606.1 1636515 1637348 D Code: S; COG: COG1806; hypothetical protein 1636515..1637348 Shigella dysenteriae Sd197 3796205 YP_403400.1 CDS aroH NC_007606.1 1637505 1638551 D DAHP synthetase, tryptophan repressible; tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1637505..1638551 Shigella dysenteriae Sd197 3796206 YP_403401.1 CDS ydiE NC_007606.1 1638683 1638874 D Code: P; COG: COG4256; hypothetical protein 1638683..1638874 Shigella dysenteriae Sd197 3796207 YP_403404.1 CDS SDY_1802 NC_007606.1 1640375 1641088 R Code: T; COG: COG2200; hypothetical protein complement(1640375..1641088) Shigella dysenteriae Sd197 3795985 YP_403405.1 CDS nlpC NC_007606.1 1641335 1641799 R Code: M; COG: COG0791; lipoprotein complement(1641335..1641799) Shigella dysenteriae Sd197 3795986 YP_403406.1 CDS btuD NC_007606.1 1641877 1642626 R ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase complement(1641877..1642626) Shigella dysenteriae Sd197 3795987 YP_403407.1 CDS btuE NC_007606.1 1642626 1643177 R similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase complement(1642626..1643177) Shigella dysenteriae Sd197 3795988 YP_403408.1 CDS btuC NC_007606.1 1643240 1644220 R with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease complement(1643240..1644220) Shigella dysenteriae Sd197 3795989 YP_403409.1 CDS ihfA NC_007606.1 1644321 1644620 R IHF; site-specific recombination; ''This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control''; integration host factor subunit alpha complement(1644321..1644620) Shigella dysenteriae Sd197 3795990 YP_403410.1 CDS pheT NC_007606.1 1644625 1647012 R ''catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily''; phenylalanyl-tRNA synthetase subunit beta complement(1644625..1647012) Shigella dysenteriae Sd197 3795991 YP_403411.1 CDS pheS NC_007606.1 1647027 1648010 R ''catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily''; phenylalanyl-tRNA synthetase subunit alpha complement(1647027..1648010) Shigella dysenteriae Sd197 3795992 YP_403413.1 CDS rplT NC_007606.1 1648460 1648816 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(1648460..1648816) Shigella dysenteriae Sd197 3795994 YP_403414.1 CDS rpmI NC_007606.1 1648869 1649066 R Code: J; COG: COG0291; 50S ribosomal protein L35 complement(1648869..1649066) Shigella dysenteriae Sd197 3795995 YP_403415.2 CDS infC NC_007606.1 1649160 1649702 R IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 complement(1649160..1649702) Shigella dysenteriae Sd197 3795996 YP_403416.1 CDS thrS NC_007606.1 1649706 1651634 R ''catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''; threonyl-tRNA synthetase complement(1649706..1651634) Shigella dysenteriae Sd197 3795997 YP_009000742.1 CDS SDY_4672 NC_007606.1 1652079 1652351 D insertion element iso-IS1N protein InsA 1652079..1652351 Shigella dysenteriae Sd197 18263056 YP_403417.1 CDS SDY_1815 NC_007606.1 1652378 1652773 D Code: L; COG: COG1662; insertion element IS1 protein InsB 1652378..1652773 Shigella dysenteriae Sd197 3795998 YP_403418.1 CDS pfkB NC_007606.1 1652940 1653869 D suppressor of pfkA; Code: G; COG: COG1105; 6-phosphofructokinase 1652940..1653869 Shigella dysenteriae Sd197 3795999 YP_403419.1 CDS SDY_1817 NC_007606.1 1653970 1654260 D hypothetical protein 1653970..1654260 Shigella dysenteriae Sd197 3796000 YP_403420.1 CDS SDY_1818 NC_007606.1 1654366 1655226 D Code: G; COG: COG3001; hypothetical protein 1654366..1655226 Shigella dysenteriae Sd197 3796001 YP_403421.1 CDS SDY_1819 NC_007606.1 1655267 1655803 R hypothetical protein complement(1655267..1655803) Shigella dysenteriae Sd197 3795691 YP_403422.1 CDS yniC NC_007606.1 1655950 1656618 D ''YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate''; 2-deoxyglucose-6-phosphatase 1655950..1656618 Shigella dysenteriae Sd197 3795692 YP_403423.2 CDS SDY_1821 NC_007606.1 1656782 1657372 D Code: R; COG: COG1988; hypothetical protein 1656782..1657372 Shigella dysenteriae Sd197 3795693 YP_403424.1 CDS insB NC_007606.1 1657435 1657812 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(1657435..1657812) Shigella dysenteriae Sd197 3795694 YP_403425.1 CDS insA NC_007606.1 1657857 1658132 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(1657857..1658132) Shigella dysenteriae Sd197 3795695 YP_403426.1 CDS rstA NC_007606.1 1658219 1658935 D RstB sensor; response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1658219..1658935 Shigella dysenteriae Sd197 3795696 YP_403427.1 CDS rstB NC_007606.1 1658939 1660240 D RstA regulator; Code: T; COG: COG0642; sensor protein RstB 1658939..1660240 Shigella dysenteriae Sd197 3795697 YP_403428.1 CDS tus NC_007606.1 1660316 1661245 D inhibition of replication at Ter sites; binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1660316..1661245 Shigella dysenteriae Sd197 3795698 YP_403429.1 CDS fumC NC_007606.1 1661242 1662645 R fumarate hydratase Class II; isozyme; class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(1661242..1662645) Shigella dysenteriae Sd197 3795699 YP_403430.1 CDS fumA NC_007606.1 1662787 1664433 R fumarate hydratase Class I; aerobic isozyme; Code: C; COG: COG1951; fumarase A complement(1662787..1664433) Shigella dysenteriae Sd197 3795700 YP_403431.1 CDS manA NC_007606.1 1664632 1665807 D Code: G; COG: COG1482; mannose-6-phosphate isomerase 1664632..1665807 Shigella dysenteriae Sd197 3795701 YP_403432.1 CDS ydgA NC_007606.1 1665908 1667416 D Code: S; COG: COG5339; hypothetical protein 1665908..1667416 Shigella dysenteriae Sd197 3795702 YP_009000743.1 CDS SDY_4673 NC_007606.1 1668648 1668920 D insertion element iso-IS1N protein InsA 1668648..1668920 Shigella dysenteriae Sd197 18263057 YP_403433.1 CDS SDY_1832 NC_007606.1 1668947 1669342 D Code: L; COG: COG1662; insertion element IS1 protein InsB 1668947..1669342 Shigella dysenteriae Sd197 3795704 YP_403437.1 CDS uidR NC_007606.1 1673679 1674269 R Code: K; COG: COG1309; DNA-binding transcriptional repressor UidR complement(1673679..1674269) Shigella dysenteriae Sd197 3795709 YP_403438.1 CDS hdhA NC_007606.1 1674498 1675265 R dehydroxylation of bile acids; Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase complement(1674498..1675265) Shigella dysenteriae Sd197 3795710 YP_403441.1 CDS malI NC_007606.1 1676800 1677828 R regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI complement(1676800..1677828) Shigella dysenteriae Sd197 3795868 YP_403442.1 CDS malX NC_007606.1 1678003 1679403 D Code: G; COG: COG1263; PTS system maltose and glucose-specific transporter subunit IIABC 1678003..1679403 Shigella dysenteriae Sd197 3795869 YP_403443.1 CDS SDY_1843 NC_007606.1 1679378 1679773 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1679378..1679773) Shigella dysenteriae Sd197 3795870 YP_009000744.1 CDS SDY_4674 NC_007606.1 1679800 1680054 R insertion element iso-IS1N protein InsA complement(1679800..1680054) Shigella dysenteriae Sd197 18263058 YP_403445.1 CDS malY NC_007606.1 1680362 1681534 D enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase; Code: E; COG: COG1168; bifunctional beta-cystathionase/maltose operon regulator MalY 1680362..1681534 Shigella dysenteriae Sd197 3795872 YP_403446.1 CDS add NC_007606.1 1681638 1682639 D catalyzes the formation of inosine from adenosine; adenosine deaminase 1681638..1682639 Shigella dysenteriae Sd197 3795873 YP_403447.2 CDS SDY_1847 NC_007606.1 1682675 1683715 R Code: R; COG: COG0673; oxidoreductase complement(1682675..1683715) Shigella dysenteriae Sd197 3795874 YP_403448.1 CDS SDY_1848 NC_007606.1 1684362 1684577 D ''YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes''; oriC-binding nucleoid-associated protein 1684362..1684577 Shigella dysenteriae Sd197 3795875 YP_403450.1 CDS SDY_1850 NC_007606.1 1685172 1685753 D Code: C; COG: COG4657; Na(+)-translocating NADH-quinone reductase subunit E 1685172..1685753 Shigella dysenteriae Sd197 3795877 YP_403451.1 CDS SDY_1851 NC_007606.1 1685753 1686331 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1685753..1686331 Shigella dysenteriae Sd197 3795878 YP_403452.1 CDS SDY_1852 NC_007606.1 1686324 1688642 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1686324..1688642 Shigella dysenteriae Sd197 3795879 YP_403453.1 CDS rnfD NC_007606.1 1688643 1689701 D RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1688643..1689701 Shigella dysenteriae Sd197 3795880 YP_403454.1 CDS SDY_1854 NC_007606.1 1689705 1690325 D part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1689705..1690325 Shigella dysenteriae Sd197 3795881 YP_403455.1 CDS ydgQ NC_007606.1 1690329 1691024 D in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex protein RsxE 1690329..1691024 Shigella dysenteriae Sd197 3795882 YP_403456.1 CDS nth NC_007606.1 1691024 1691659 D specific for apurinic and/or apyrimidinic sites; ''DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines''; endonuclease III 1691024..1691659 Shigella dysenteriae Sd197 3795883 YP_403457.1 CDS tppB NC_007606.1 1692270 1693772 D mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 1692270..1693772 Shigella dysenteriae Sd197 3795884 YP_403458.1 CDS gst NC_007606.1 1693878 1694483 D Code: O; COG: COG0625; glutathionine S-transferase 1693878..1694483 Shigella dysenteriae Sd197 3795769 YP_403459.1 CDS pdxY NC_007606.1 1694527 1695390 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase complement(1694527..1695390) Shigella dysenteriae Sd197 3795770 YP_403460.1 CDS tyrS NC_007606.1 1695449 1696723 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(1695449..1696723) Shigella dysenteriae Sd197 3795771 YP_403461.1 CDS pdxH NC_007606.1 1696852 1697508 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(1696852..1697508) Shigella dysenteriae Sd197 3795772 YP_403462.2 CDS ydhA NC_007606.1 1697567 1697896 R Code: R; COG: COG3895; hypothetical protein complement(1697567..1697896) Shigella dysenteriae Sd197 3795773 YP_403463.1 CDS anmK NC_007606.1 1697994 1699103 R ''catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling''; anhydro-N-acetylmuramic acid kinase complement(1697994..1699103) Shigella dysenteriae Sd197 3795774 YP_403464.1 CDS slyB NC_007606.1 1699377 1699844 D Code: M; COG: COG3133; outer membrane protein 1699377..1699844 Shigella dysenteriae Sd197 3795775 YP_403465.2 CDS slyA NC_007606.1 1699891 1700325 R Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA complement(1699891..1700325) Shigella dysenteriae Sd197 3795776 YP_403466.1 CDS SDY_1866 NC_007606.1 1700526 1700762 D hypothetical protein 1700526..1700762 Shigella dysenteriae Sd197 3795777 YP_403467.1 CDS SDY_1867 NC_007606.1 1700723 1701622 D Code: V; COG: COG1566; hypothetical protein 1700723..1701622 Shigella dysenteriae Sd197 3795778 YP_403470.1 CDS sodC NC_007606.1 1703649 1704170 R SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase complement(1703649..1704170) Shigella dysenteriae Sd197 3795781 YP_403471.1 CDS SDY_1871 NC_007606.1 1704251 1705147 R Code: R; COG: COG4989; hypothetical protein complement(1704251..1705147) Shigella dysenteriae Sd197 3795782 YP_403472.1 CDS SDY_1873 NC_007606.1 1705196 1705573 R Code: R; COG: COG3313; hypothetical protein complement(1705196..1705573) Shigella dysenteriae Sd197 3795784 YP_403473.1 CDS SDY_1872 NC_007606.1 1705538 1706137 D Code: K; COG: COG1309; hypothetical protein 1705538..1706137 Shigella dysenteriae Sd197 3795783 YP_403474.1 CDS SDY_1874 NC_007606.1 1706252 1706647 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1706252..1706647) Shigella dysenteriae Sd197 3795785 YP_009000745.1 CDS SDY_4675 NC_007606.1 1706674 1706946 R insertion element iso-IS1N protein InsA complement(1706674..1706946) Shigella dysenteriae Sd197 18263059 YP_403477.1 CDS gloA NC_007606.1 1708126 1708533 D Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1708126..1708533 Shigella dysenteriae Sd197 3795788 YP_403478.1 CDS rnt NC_007606.1 1708636 1709283 D Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1708636..1709283 Shigella dysenteriae Sd197 3798217 YP_403479.1 CDS ydhD NC_007606.1 1714043 1714390 R Code: O; COG: COG0278; hypothetical protein complement(1714043..1714390) Shigella dysenteriae Sd197 3798219 YP_403480.1 CDS ydhO NC_007606.1 1714725 1715552 D Code: M; COG: COG0791; lipoprotein 1714725..1715552 Shigella dysenteriae Sd197 3798220 YP_403481.1 CDS sodB NC_007606.1 1715680 1716261 D SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1715680..1716261 Shigella dysenteriae Sd197 3798221 YP_403482.1 CDS SDY_1883 NC_007606.1 1716407 1717576 R Code: G; COG: COG2814; transport protein complement(1716407..1717576) Shigella dysenteriae Sd197 3798222 YP_403483.1 CDS purR NC_007606.1 1718130 1719155 D transcriptional repressor for pur regulon, glyA, glnB, prsA, speA; ''binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers''; DNA-binding transcriptional repressor PurR 1718130..1719155 Shigella dysenteriae Sd197 3798223 YP_403484.1 CDS ydhB NC_007606.1 1719152 1720084 R Code: K; COG: COG0583; DNA-binding transcriptional regulator complement(1719152..1720084) Shigella dysenteriae Sd197 3798224 YP_403485.1 CDS ydhC NC_007606.1 1720197 1721408 D uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1720197..1721408 Shigella dysenteriae Sd197 3798225 YP_403486.1 CDS cfa NC_007606.1 1721699 1722847 D catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane-fatty-acyl-phospholipid synthase 1721699..1722847 Shigella dysenteriae Sd197 3798226 YP_403487.1 CDS ribE NC_007606.1 1722887 1723528 R ''catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine''; riboflavin synthase subunit alpha complement(1722887..1723528) Shigella dysenteriae Sd197 3798227 YP_009000746.1 CDS SDY_4676 NC_007606.1 1723679 1723951 D insertion element iso-IS1N protein InsA 1723679..1723951 Shigella dysenteriae Sd197 18263060 YP_403488.1 CDS SDY_1889 NC_007606.1 1723978 1724373 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1723978..1724373 Shigella dysenteriae Sd197 3798228 YP_403489.1 CDS ydhE NC_007606.1 1724517 1725890 D NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1724517..1725890 Shigella dysenteriae Sd197 3798229 YP_403490.1 CDS SDY_1891 NC_007606.1 1725931 1727187 R Code: MU; COG: COG3468; hypothetical protein complement(1725931..1727187) Shigella dysenteriae Sd197 3798230 YP_403492.1 CDS SDY_1895 NC_007606.1 1728805 1729107 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(1728805..1729107) Shigella dysenteriae Sd197 3798311 YP_403494.1 CDS SDY_1897 NC_007606.1 1730729 1731541 R hypothetical protein complement(1730729..1731541) Shigella dysenteriae Sd197 3798313 YP_403495.1 CDS ydhU NC_007606.1 1731545 1732330 R Code: C; COG: COG4117; hypothetical protein complement(1731545..1732330) Shigella dysenteriae Sd197 3798314 YP_403496.1 CDS SDY_1899 NC_007606.1 1732327 1733046 R Code: C; COG: COG0437; oxidoreductase Fe-S subunit complement(1732327..1733046) Shigella dysenteriae Sd197 3798315 YP_403497.1 CDS SDY_1900 NC_007606.1 1733059 1733706 R hypothetical protein complement(1733059..1733706) Shigella dysenteriae Sd197 3798316 YP_403498.1 CDS SDY_1901 NC_007606.1 1733875 1734177 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1733875..1734177 Shigella dysenteriae Sd197 3798317 YP_403501.1 CDS SDY_1904 NC_007606.1 1735129 1735338 R hypothetical protein complement(1735129..1735338) Shigella dysenteriae Sd197 3798320 YP_403502.1 CDS pykF NC_007606.1 1735895 1737307 D formerly F; catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1735895..1737307 Shigella dysenteriae Sd197 3798321 YP_403503.1 CDS insA NC_007606.1 1737495 1737770 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1737495..1737770 Shigella dysenteriae Sd197 3798322 YP_403505.1 CDS lpp NC_007606.1 1738394 1738630 D Code: M; COG: COG4238; murein lipoprotein 1738394..1738630 Shigella dysenteriae Sd197 3798324 YP_403506.1 CDS ynhG NC_007606.1 1738693 1739697 R Code: S; COG: COG1376; hypothetical protein complement(1738693..1739697) Shigella dysenteriae Sd197 3798325 YP_403507.1 CDS ynhA NC_007606.1 1739846 1740262 R Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE complement(1739846..1740262) Shigella dysenteriae Sd197 3798326 YP_403509.1 CDS ynhC NC_007606.1 1741492 1742763 R with SufBC activates cysteine desulfurase SufS; cysteine desulfurase complement(1741492..1742763) Shigella dysenteriae Sd197 3798328 YP_403510.1 CDS sufC NC_007606.1 1742738 1743484 R part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase complement(1742738..1743484) Shigella dysenteriae Sd197 3798329 YP_403512.1 CDS SDY_1915 NC_007606.1 1744550 1745287 R phage Mu Mom-like protein complement(1744550..1745287) Shigella dysenteriae Sd197 3796443 YP_403513.1 CDS SDY_1916 NC_007606.1 1745479 1746072 R Code: L; COG: COG1961; DNA-invertase complement(1745479..1746072) Shigella dysenteriae Sd197 3796444 YP_403514.1 CDS SDY_1917 NC_007606.1 1746264 1746758 D hypothetical protein 1746264..1746758 Shigella dysenteriae Sd197 3796445 YP_403515.1 CDS SDY_1918 NC_007606.1 1746783 1747631 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(1746783..1747631) Shigella dysenteriae Sd197 3796446 YP_403516.1 CDS SDY_1919 NC_007606.1 1749620 1750015 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1749620..1750015) Shigella dysenteriae Sd197 3796447 YP_009000747.1 CDS SDY_4677 NC_007606.1 1750042 1750314 R insertion element iso-IS1N protein InsA complement(1750042..1750314) Shigella dysenteriae Sd197 18263061 YP_403517.1 CDS SDY_1920 NC_007606.1 1750428 1750730 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1750428..1750730 Shigella dysenteriae Sd197 3796448 YP_403519.1 CDS SDY_1922 NC_007606.1 1751625 1752287 R Fels-1 prophage DNA or RNA helicases of superfamily II; hypothetical protein complement(1751625..1752287) Shigella dysenteriae Sd197 3796450 YP_403520.1 CDS SDY_1923 NC_007606.1 1752281 1752652 R hypothetical protein complement(1752281..1752652) Shigella dysenteriae Sd197 3796451 YP_403521.1 CDS SDY_1924 NC_007606.1 1753199 1753402 R hypothetical protein complement(1753199..1753402) Shigella dysenteriae Sd197 3796452 YP_403522.1 CDS SDY_1925 NC_007606.1 1753498 1754211 D Code: KT; COG: COG1974; repressor protein CI 1753498..1754211 Shigella dysenteriae Sd197 3796453 YP_403523.1 CDS SDY_1926 NC_007606.1 1754305 1755774 D adenine-specific; site-specific DNA-methyltransferase 1754305..1755774 Shigella dysenteriae Sd197 3796454 YP_403524.1 CDS SDY_1927 NC_007606.1 1755771 1756724 D type II site-specific deoxyribonuclease 1755771..1756724 Shigella dysenteriae Sd197 3796455 YP_403525.1 CDS SDY_1928 NC_007606.1 1757618 1758034 D hypothetical protein 1757618..1758034 Shigella dysenteriae Sd197 3796456 YP_403526.1 CDS SDY_1929 NC_007606.1 1758031 1758264 D hypothetical protein 1758031..1758264 Shigella dysenteriae Sd197 3796457 YP_403529.1 CDS SDY_1932 NC_007606.1 1759284 1759586 R Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN complement(1759284..1759586) Shigella dysenteriae Sd197 3796460 YP_403530.1 CDS SDY_1933 NC_007606.1 1759633 1759800 D prophage Kil protein 1759633..1759800 Shigella dysenteriae Sd197 3796461 YP_403531.1 CDS insA NC_007606.1 1759856 1760131 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1759856..1760131 Shigella dysenteriae Sd197 3798689 YP_009000748.1 CDS SDY_1934a NC_007606.1 1760176 1760553 D insertion sequence element IS1 transposase 1760176..1760553 Shigella dysenteriae Sd197 18263062 YP_403532.1 CDS pspE NC_007606.1 1761846 1762160 R rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase complement(1761846..1762160) Shigella dysenteriae Sd197 3798691 YP_403533.1 CDS pspD NC_007606.1 1762235 1762456 R peripheral inner membrane phage-shock protein complement(1762235..1762456) Shigella dysenteriae Sd197 3798692 YP_403534.1 CDS pspC NC_007606.1 1762465 1762824 R activates phage shock-protein expression; ''with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock''; DNA-binding transcriptional activator PspC complement(1762465..1762824) Shigella dysenteriae Sd197 3798693 YP_403535.1 CDS pspB NC_007606.1 1762824 1763048 R ''acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding''; phage shock protein B complement(1762824..1763048) Shigella dysenteriae Sd197 3798694 YP_403536.1 CDS pspA NC_007606.1 1763102 1763770 R inner membrane protein; involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA complement(1763102..1763770) Shigella dysenteriae Sd197 3798695 YP_403537.2 CDS pspF NC_007606.1 1763937 1764914 D ''transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor''; phage shock protein operon transcriptional activator 1763937..1764914 Shigella dysenteriae Sd197 3798696 YP_403538.1 CDS ordL NC_007606.1 1766347 1767627 R Code: E; COG: COG0665; oxidoreductase complement(1766347..1767627) Shigella dysenteriae Sd197 3798698 YP_403539.1 CDS ycjC NC_007606.1 1769266 1769823 R regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR complement(1769266..1769823) Shigella dysenteriae Sd197 3798700 YP_403541.1 CDS SDY_1949 NC_007606.1 1773369 1773764 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1773369..1773764) Shigella dysenteriae Sd197 3798704 YP_009000749.1 CDS SDY_4678 NC_007606.1 1773791 1774063 R insertion element iso-IS1N protein InsA complement(1773791..1774063) Shigella dysenteriae Sd197 18263063 YP_403542.1 CDS SDY_1950 NC_007606.1 1774286 1774498 R hypothetical protein complement(1774286..1774498) Shigella dysenteriae Sd197 3798705 YP_403543.1 CDS SDY_1951 NC_007606.1 1774574 1775182 R Code: O; COG: COG0625; transferase complement(1774574..1775182) Shigella dysenteriae Sd197 3798706 YP_403544.1 CDS ansP NC_007606.1 1775398 1776948 D Code: E; COG: COG1113; L-asparagine permease 1775398..1776948 Shigella dysenteriae Sd197 3798707 YP_403545.1 CDS SDY_1953 NC_007606.1 1777061 1778122 R Code: S; COG: COG3391; receptor complement(1777061..1778122) Shigella dysenteriae Sd197 3798708 YP_403546.2 CDS SDY_1954 NC_007606.1 1778364 1780067 D Code: P; COG: COG1629; outer membrane receptor for iron transport 1778364..1780067 Shigella dysenteriae Sd197 3798080 YP_009000750.1 CDS SDY_4679 NC_007606.1 1780361 1780633 D insertion element iso-IS1N protein InsA 1780361..1780633 Shigella dysenteriae Sd197 18263064 YP_403548.1 CDS SDY_1956 NC_007606.1 1780660 1781055 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1780660..1781055 Shigella dysenteriae Sd197 3798082 YP_403549.1 CDS SDY_1957 NC_007606.1 1781276 1781713 R Code: K; COG: COG1802; hypothetical protein complement(1781276..1781713) Shigella dysenteriae Sd197 3798083 YP_403550.1 CDS insA NC_007606.1 1781775 1782050 D Code: L; COG: COG3677; insertion element IS1 protein InsA 1781775..1782050 Shigella dysenteriae Sd197 3798084 YP_403551.1 CDS insB NC_007606.1 1782095 1782472 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1782095..1782472 Shigella dysenteriae Sd197 3798085 YP_403554.1 CDS yoaE NC_007606.1 1783914 1785464 R Code: R; COG: COG1253; transport protein complement(1783914..1785464) Shigella dysenteriae Sd197 3798088 YP_403555.1 CDS manX NC_007606.1 1785928 1786899 D Code: G; COG: COG2893; PTS system mannose-specific transporter subunit IIAB 1785928..1786899 Shigella dysenteriae Sd197 3798089 YP_403556.1 CDS manZ NC_007606.1 1787767 1788627 D hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1787767..1788627 Shigella dysenteriae Sd197 3798091 YP_403557.1 CDS SDY_1966 NC_007606.1 1788682 1789140 D Code: S; COG: COG4811; hypothetical protein 1788682..1789140 Shigella dysenteriae Sd197 3798092 YP_403558.1 CDS SDY_1967 NC_007606.1 1789515 1790135 D membrane protein YebN; hypothetical protein 1789515..1790135 Shigella dysenteriae Sd197 3798093 YP_403559.1 CDS rrmA NC_007606.1 1790132 1790941 R methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase complement(1790132..1790941) Shigella dysenteriae Sd197 3798094 YP_403560.1 CDS cspC NC_007606.1 1791107 1791316 R Code: K; COG: COG1278; cold shock-like protein CspC complement(1791107..1791316) Shigella dysenteriae Sd197 3798095 YP_403561.1 CDS SDY_1970 NC_007606.1 1791329 1791472 R hypothetical protein complement(1791329..1791472) Shigella dysenteriae Sd197 3798096 YP_009000751.1 CDS SDY_4680 NC_007606.1 1792051 1792323 D insertion element iso-IS1N protein InsA 1792051..1792323 Shigella dysenteriae Sd197 18263065 YP_403562.1 CDS SDY_1971 NC_007606.1 1792350 1792745 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1792350..1792745 Shigella dysenteriae Sd197 3798097 YP_403563.1 CDS SDY_1972 NC_007606.1 1792762 1793049 R hypothetical protein complement(1792762..1793049) Shigella dysenteriae Sd197 3798098 YP_403564.1 CDS SDY_1973 NC_007606.1 1793124 1793267 R hypothetical protein complement(1793124..1793267) Shigella dysenteriae Sd197 3798822 YP_403565.1 CDS SDY_1974 NC_007606.1 1793426 1793665 D hypothetical protein 1793426..1793665 Shigella dysenteriae Sd197 3798823 YP_403566.1 CDS SDY_1975 NC_007606.1 1793809 1794600 R Code: K; COG: COG1414; regulator complement(1793809..1794600) Shigella dysenteriae Sd197 3798824 YP_403567.1 CDS SDY_1976 NC_007606.1 1794666 1796048 D Code: GEPR; COG: COG0477; transport protein 1794666..1796048 Shigella dysenteriae Sd197 3798825 YP_403568.1 CDS htpX NC_007606.1 1796191 1797072 R integral membrane protein; metalloprotease; heat shock protein HtpX complement(1796191..1797072) Shigella dysenteriae Sd197 3798826 YP_403569.1 CDS prc NC_007606.1 1797264 1799312 R Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease complement(1797264..1799312) Shigella dysenteriae Sd197 3798827 YP_403570.1 CDS proQ NC_007606.1 1799332 1800030 R affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector complement(1799332..1800030) Shigella dysenteriae Sd197 3798828 YP_403571.1 CDS SDY_1980 NC_007606.1 1800127 1800678 R Code: T; COG: COG1956; hypothetical protein complement(1800127..1800678) Shigella dysenteriae Sd197 3798829 YP_403572.1 CDS SDY_1981 NC_007606.1 1800754 1801074 D hypothetical protein 1800754..1801074 Shigella dysenteriae Sd197 3798830 YP_403573.1 CDS SDY_1982 NC_007606.1 1801111 1801611 D hypothetical protein 1801111..1801611 Shigella dysenteriae Sd197 3798831 YP_009000752.1 CDS SDY_4681 NC_007606.1 1801651 1801923 D insertion element iso-IS1N protein InsA 1801651..1801923 Shigella dysenteriae Sd197 18263066 YP_403574.1 CDS SDY_1983 NC_007606.1 1801950 1802345 D Code: L; COG: COG1662; insertion element IS1 protein InsB 1801950..1802345 Shigella dysenteriae Sd197 3798832 YP_403575.1 CDS SDY_1984 NC_007606.1 1802375 1802812 D hypothetical protein 1802375..1802812 Shigella dysenteriae Sd197 3798833 YP_403576.1 CDS SDY_1985 NC_007606.1 1802775 1805402 D Code: R; COG: COG3008; hypothetical protein 1802775..1805402 Shigella dysenteriae Sd197 3798834 YP_403577.1 CDS yebU NC_007606.1 1805476 1806921 D in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 1805476..1806921 Shigella dysenteriae Sd197 3798835 YP_403578.1 CDS SDY_1987 NC_007606.1 1807024 1807275 D hypothetical protein 1807024..1807275 Shigella dysenteriae Sd197 3798836 YP_403579.2 CDS SDY_1988 NC_007606.1 1807380 1807571 D hypothetical protein 1807380..1807571 Shigella dysenteriae Sd197 3798837 YP_403581.1 CDS SDY_1991 NC_007606.1 1808751 1809053 D Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 1808751..1809053 Shigella dysenteriae Sd197 3798840 YP_403582.1 CDS SDY_1992 NC_007606.1 1809080 1809919 D Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein 1809080..1809919 Shigella dysenteriae Sd197 3798841 YP_403583.1 CDS SDY_1993 NC_007606.1 1809934 1810203 R hypothetical protein complement(1809934..1810203) Shigella dysenteriae Sd197 3797538 YP_403584.1 CDS ybcR NC_007606.1 1810827 1811042 D hypothetical protein 1810827..1811042 Shigella dysenteriae Sd197 3797543 YP_403585.1 CDS SDY_1999 NC_007606.1 1811227 1811529 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1811227..1811529 Shigella dysenteriae Sd197 3797544 YP_403587.1 CDS ipaH_4 NC_007606.1 1812689 1814404 R Code: S; COG: COG4886; invasion plasmid antigen complement(1812689..1814404) Shigella dysenteriae Sd197 3797546 YP_009000753.1 CDS SDY_4682 NC_007606.1 1814862 1815134 D insertion element iso-IS1N protein InsA 1814862..1815134 Shigella dysenteriae Sd197 18263067 YP_403588.1 CDS SDY_2002 NC_007606.1 1815161 1815556 D Code: L; COG: COG1662; insertion element IS1 protein InsB 1815161..1815556 Shigella dysenteriae Sd197 3797547 YP_403589.1 CDS ipaH_5 NC_007606.1 1816133 1817884 D Code: S; COG: COG4886; invasion plasmid antigen 1816133..1817884 Shigella dysenteriae Sd197 3797548 YP_403592.1 CDS SDY_2006 NC_007606.1 1819408 1819680 R hypothetical protein complement(1819408..1819680) Shigella dysenteriae Sd197 3797551 YP_403593.1 CDS SDY_2007 NC_007606.1 1819681 1820076 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1819681..1820076) Shigella dysenteriae Sd197 3797552 YP_009000754.1 CDS SDY_4683 NC_007606.1 1820103 1820375 R insertion element iso-IS1N protein InsA complement(1820103..1820375) Shigella dysenteriae Sd197 18263068 YP_403594.1 CDS SDY_2008 NC_007606.1 1820489 1820791 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1820489..1820791 Shigella dysenteriae Sd197 3799904 YP_403597.1 CDS ybhE NC_007606.1 1821904 1822899 D catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 1821904..1822899 Shigella dysenteriae Sd197 3799907 YP_403598.1 CDS SDY_2012 NC_007606.1 1822940 1823392 R hypothetical protein complement(1822940..1823392) Shigella dysenteriae Sd197 3799908 YP_403599.1 CDS SDY_2013 NC_007606.1 1823444 1823839 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1823444..1823839) Shigella dysenteriae Sd197 3799909 YP_009000755.1 CDS SDY_4684 NC_007606.1 1823866 1824138 R insertion element iso-IS1N protein InsA complement(1823866..1824138) Shigella dysenteriae Sd197 18263069 YP_403601.1 CDS ycgW NC_007606.1 1824467 1824790 D hypothetical protein 1824467..1824790 Shigella dysenteriae Sd197 3799911 YP_403602.1 CDS icdA NC_007606.1 1824893 1826143 R Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase complement(1824893..1826143) Shigella dysenteriae Sd197 3799912 YP_403603.1 CDS ymfC NC_007606.1 1826345 1826968 D catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 1826345..1826968 Shigella dysenteriae Sd197 3799913 YP_403604.1 CDS SDY_2018 NC_007606.1 1826978 1827439 D Code: LR; COG: COG0494; phosphohydrolase 1826978..1827439 Shigella dysenteriae Sd197 3799914 YP_403605.2 CDS mnmA NC_007606.1 1827493 1828599 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1827493..1828599 Shigella dysenteriae Sd197 3799915 YP_403606.1 CDS ycfC NC_007606.1 1828635 1829276 D HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1828635..1829276 Shigella dysenteriae Sd197 3799916 YP_403607.1 CDS purB NC_007606.1 1829280 1830650 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1829280..1830650 Shigella dysenteriae Sd197 3799917 YP_403608.1 CDS phoP NC_007606.1 1830819 1831490 D response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 1830819..1831490 Shigella dysenteriae Sd197 3799918 YP_403609.1 CDS phoQ NC_007606.1 1831490 1832950 D Code: T; COG: COG0642; sensor protein PhoQ 1831490..1832950 Shigella dysenteriae Sd197 3799919 YP_403610.1 CDS ycfD NC_007606.1 1833017 1834147 D Code: S; COG: COG2850; hypothetical protein 1833017..1834147 Shigella dysenteriae Sd197 3799920 YP_403611.1 CDS pepT NC_007606.1 1834196 1835422 R catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T complement(1834196..1835422) Shigella dysenteriae Sd197 3799921 YP_403612.1 CDS potA NC_007606.1 1835672 1836808 D functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 1835672..1836808 Shigella dysenteriae Sd197 3799922 YP_403613.1 CDS potB NC_007606.1 1836822 1837649 D can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter permease 1836822..1837649 Shigella dysenteriae Sd197 3799768 YP_403614.1 CDS potC NC_007606.1 1837646 1838440 D can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter permease 1837646..1838440 Shigella dysenteriae Sd197 3799769 YP_403615.1 CDS potD NC_007606.1 1838437 1839483 D can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter substrate-binding protein 1838437..1839483 Shigella dysenteriae Sd197 3799770 YP_403616.1 CDS cobB NC_007606.1 1839639 1840460 R Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase complement(1839639..1840460) Shigella dysenteriae Sd197 3799771 YP_403617.1 CDS ycfX NC_007606.1 1840476 1841387 R catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase complement(1840476..1841387) Shigella dysenteriae Sd197 3799772 YP_403618.1 CDS ycfW NC_007606.1 1841416 1842660 R part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE complement(1841416..1842660) Shigella dysenteriae Sd197 3799773 YP_403619.2 CDS lolD NC_007606.1 1842660 1843361 R ''outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone''; lipoprotein ABC transporter ATP-binding subunit complement(1842660..1843361) Shigella dysenteriae Sd197 3799774 YP_403620.1 CDS ycfU NC_007606.1 1843354 1844553 R part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC complement(1843354..1844553) Shigella dysenteriae Sd197 3799775 YP_403621.1 CDS ycfT NC_007606.1 1844815 1845888 D Code: S; COG: COG4763; hypothetical protein 1844815..1845888 Shigella dysenteriae Sd197 3799776 YP_403622.1 CDS mfd NC_007606.1 1846016 1849462 D mutation frequency decline; Code: LK; COG: COG1197; transcription-repair coupling factor 1846016..1849462 Shigella dysenteriae Sd197 3799777 YP_403623.1 CDS ycfS NC_007606.1 1849604 1850566 D Code: S; COG: COG1376; hypothetical protein 1849604..1850566 Shigella dysenteriae Sd197 3799778 YP_403624.1 CDS ycfR NC_007606.1 1850649 1850906 R hypothetical protein complement(1850649..1850906) Shigella dysenteriae Sd197 3799779 YP_403625.1 CDS ycfQ NC_007606.1 1851069 1851779 D Code: K; COG: COG1309; hypothetical protein 1851069..1851779 Shigella dysenteriae Sd197 3799780 YP_403626.1 CDS ycfJ NC_007606.1 1851841 1852380 R Code: S; COG: COG3134; hypothetical protein complement(1851841..1852380) Shigella dysenteriae Sd197 3799781 YP_403627.1 CDS ndh NC_007606.1 1852607 1853911 R Code: C; COG: COG1252; respiratory NADH dehydrogenase complement(1852607..1853911) Shigella dysenteriae Sd197 3799782 YP_403628.2 CDS ycfP NC_007606.1 1854317 1854859 R Code: R; COG: COG3150; hypothetical protein complement(1854317..1854859) Shigella dysenteriae Sd197 3799783 YP_403629.1 CDS ycfO NC_007606.1 1854882 1855907 R hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase complement(1854882..1855907) Shigella dysenteriae Sd197 3799784 YP_403630.1 CDS thiK NC_007606.1 1855918 1856742 R catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase complement(1855918..1856742) Shigella dysenteriae Sd197 3799785 YP_403631.1 CDS ycfM NC_007606.1 1856723 1857364 R Code: R; COG: COG3417; hypothetical protein complement(1856723..1857364) Shigella dysenteriae Sd197 3799786 YP_403632.1 CDS ycfL NC_007606.1 1857378 1857755 R Code: R; COG: COG5633; hypothetical protein complement(1857378..1857755) Shigella dysenteriae Sd197 3799787 YP_403633.1 CDS ycfF NC_007606.1 1857758 1858117 R Code: FGR; COG: COG0537; purine nucleoside phosphoramidase complement(1857758..1858117) Shigella dysenteriae Sd197 3799518 YP_403634.1 CDS fhuE NC_007606.1 1858440 1860629 D Code: P; COG: COG4773; ferric-rhodotorulic acid outer membrane transporter 1858440..1860629 Shigella dysenteriae Sd197 3799519 YP_403635.1 CDS ptsG NC_007606.1 1860689 1862122 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunit IIBC complement(1860689..1862122) Shigella dysenteriae Sd197 3799520 YP_403636.1 CDS ycfH NC_007606.1 1862417 1863214 R Code: L; COG: COG0084; metallodependent hydrolase complement(1862417..1863214) Shigella dysenteriae Sd197 3799521 YP_403637.1 CDS holB NC_007606.1 1863225 1864229 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' complement(1863225..1864229) Shigella dysenteriae Sd197 3799522 YP_403638.1 CDS tmk NC_007606.1 1864226 1864867 R catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase complement(1864226..1864867) Shigella dysenteriae Sd197 3799523 YP_403639.1 CDS yceG NC_007606.1 1864857 1865879 R Code: R; COG: COG1559; hypothetical protein complement(1864857..1865879) Shigella dysenteriae Sd197 3799524 YP_403640.1 CDS pabC NC_007606.1 1865882 1866691 R catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase complement(1865882..1866691) Shigella dysenteriae Sd197 3799525 YP_403641.1 CDS fabF NC_007606.1 1866811 1868052 R ''FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP''; 3-oxoacyl-ACP synthase complement(1866811..1868052) Shigella dysenteriae Sd197 3799526 YP_403642.1 CDS acpP NC_007606.1 1868138 1868374 R carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein complement(1868138..1868374) Shigella dysenteriae Sd197 3799527 YP_403643.1 CDS fabG NC_007606.1 1868585 1869319 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(1868585..1869319) Shigella dysenteriae Sd197 3799528 YP_403644.1 CDS fabD NC_007606.1 1869332 1870261 R Code: I; COG: COG0331; malonyl CoA-ACP transacylase complement(1869332..1870261) Shigella dysenteriae Sd197 3799529 YP_403645.1 CDS fabH NC_007606.1 1870277 1871230 R acetylCoA ACP transacylase; FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase complement(1870277..1871230) Shigella dysenteriae Sd197 3799530 YP_403646.2 CDS plsX NC_007606.1 1871298 1872368 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX complement(1871298..1872368) Shigella dysenteriae Sd197 3799531 YP_403647.1 CDS rpmF NC_007606.1 1872449 1872622 R some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 complement(1872449..1872622) Shigella dysenteriae Sd197 3799532 YP_403648.1 CDS yceD NC_007606.1 1872674 1873195 R Code: R; COG: COG1399; hypothetical protein complement(1872674..1873195) Shigella dysenteriae Sd197 3799533 YP_403649.1 CDS SDY_2063 NC_007606.1 1873768 1874163 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1873768..1874163) Shigella dysenteriae Sd197 3799534 YP_403651.1 CDS yceC NC_007606.1 1874864 1875823 R ''catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA''; 23S rRNA pseudouridylate synthase C complement(1874864..1875823) Shigella dysenteriae Sd197 3799536 YP_403652.1 CDS SDY_2066 NC_007606.1 1875941 1876315 R hypothetical protein complement(1875941..1876315) Shigella dysenteriae Sd197 3799498 YP_403653.1 CDS rne NC_007606.1 1876396 1879581 D membrane attachment, mRNA turnover, maturation 5S RNA; ''bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase''; ribonuclease E 1876396..1879581 Shigella dysenteriae Sd197 3799499 YP_403655.1 CDS flgJ NC_007606.1 1882427 1883368 R flagellar biosynthesis; Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ complement(1882427..1883368) Shigella dysenteriae Sd197 3799502 YP_403656.1 CDS flgI NC_007606.1 1883368 1884465 R ''part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum''; flagellar basal body P-ring biosynthesis protein FlgA complement(1883368..1884465) Shigella dysenteriae Sd197 3799503 YP_403657.1 CDS flgH NC_007606.1 1884477 1885175 R flagellar biosynthesis; lipopolysaccharide layer; ''part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod''; flagellar basal body L-ring protein complement(1884477..1885175) Shigella dysenteriae Sd197 3799504 YP_403658.1 CDS flgE NC_007606.1 1886919 1888127 R flagellar biosynthesis; the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE complement(1886919..1888127) Shigella dysenteriae Sd197 3799507 YP_403659.1 CDS flgD NC_007606.1 1888152 1888847 R flagellar biosynthesis; ''acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production''; flagellar basal body rod modification protein complement(1888152..1888847) Shigella dysenteriae Sd197 3799508 YP_403660.1 CDS flgC NC_007606.1 1888859 1889263 R flagellar biosynthesis; with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC complement(1888859..1889263) Shigella dysenteriae Sd197 3799509 YP_403661.1 CDS flgB NC_007606.1 1889267 1889683 R flagellar biosynthesis; with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal-body rod protein FlgB complement(1889267..1889683) Shigella dysenteriae Sd197 3799510 YP_009000756.1 CDS SDY_4685 NC_007606.1 1889767 1890039 D insertion element iso-IS1N protein InsA 1889767..1890039 Shigella dysenteriae Sd197 18263070 YP_403662.1 CDS SDY_2079 NC_007606.1 1890066 1890461 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1890066..1890461 Shigella dysenteriae Sd197 3799511 YP_403663.1 CDS flgA NC_007606.1 1890612 1891271 D flagellar biosynthesis; required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 1890612..1891271 Shigella dysenteriae Sd197 3799512 YP_403664.1 CDS flgM NC_007606.1 1891347 1891640 D anti-sigma factor; also known as RflB protein; regulates the flagellar specific sigma28 transcription factor; anti-sigma-28 factor FlgM 1891347..1891640 Shigella dysenteriae Sd197 3799513 YP_403665.1 CDS mviN NC_007606.1 1892093 1893628 R Code: R; COG: COG0728; virulence factor complement(1892093..1893628) Shigella dysenteriae Sd197 3799515 YP_403666.1 CDS mviM NC_007606.1 1893738 1894661 R Code: R; COG: COG0673; virulence factor complement(1893738..1894661) Shigella dysenteriae Sd197 3799516 YP_403667.1 CDS yceH NC_007606.1 1894663 1895310 R Code: S; COG: COG3132; hypothetical protein complement(1894663..1895310) Shigella dysenteriae Sd197 3799517 YP_403668.1 CDS rimJ NC_007606.1 1895321 1895905 R Code: J; COG: COG1670; ribosomal-protein-S5-alanine N-acetyltransferase complement(1895321..1895905) Shigella dysenteriae Sd197 3798842 YP_403669.1 CDS SDY_2087 NC_007606.1 1896075 1896470 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1896075..1896470) Shigella dysenteriae Sd197 3798843 YP_009000757.1 CDS SDY_4686 NC_007606.1 1896497 1896769 R insertion element iso-IS1N protein InsA complement(1896497..1896769) Shigella dysenteriae Sd197 18263071 YP_403671.1 CDS grxB NC_007606.1 1898185 1898832 D cofactor involved in the reduction of disulfides; glutaredoxin 1898185..1898832 Shigella dysenteriae Sd197 3798845 YP_403672.1 CDS yceB NC_007606.1 1898966 1899526 D hypothetical protein 1898966..1899526 Shigella dysenteriae Sd197 3798846 YP_403673.1 CDS pyrC NC_007606.1 1899632 1900678 D catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1899632..1900678 Shigella dysenteriae Sd197 3798847 YP_403674.1 CDS dinI NC_007606.1 1900752 1900997 D DNA damage-inducible protein I 1900752..1900997 Shigella dysenteriae Sd197 3798848 YP_403675.1 CDS SDY_2093 NC_007606.1 1901073 1901468 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1901073..1901468) Shigella dysenteriae Sd197 3798849 YP_009000758.1 CDS SDY_4687 NC_007606.1 1901495 1901767 R insertion element iso-IS1N protein InsA complement(1901495..1901767) Shigella dysenteriae Sd197 18263072 YP_403677.1 CDS bssS NC_007606.1 1902061 1902315 D ''BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing''; biofilm formation regulatory protein BssS 1902061..1902315 Shigella dysenteriae Sd197 3798851 YP_403678.1 CDS solA NC_007606.1 1902430 1903548 D catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 1902430..1903548 Shigella dysenteriae Sd197 3798852 YP_403679.1 CDS yceO NC_007606.1 1903569 1903709 D hypothetical protein 1903569..1903709 Shigella dysenteriae Sd197 3798853 YP_403680.1 CDS SDY_2098 NC_007606.1 1903913 1904308 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1903913..1904308) Shigella dysenteriae Sd197 3798854 YP_009000759.1 CDS SDY_4688 NC_007606.1 1904335 1904607 R insertion element iso-IS1N protein InsA complement(1904335..1904607) Shigella dysenteriae Sd197 18263073 YP_403681.1 CDS yeiL NC_007606.1 1904733 1905392 R activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL complement(1904733..1905392) Shigella dysenteriae Sd197 3798855 YP_403682.2 CDS SDY_2100 NC_007606.1 1905416 1905811 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1905416..1905811) Shigella dysenteriae Sd197 3798856 YP_009000760.1 CDS SDY_4689 NC_007606.1 1905838 1906110 R insertion element iso-IS1N protein InsA complement(1905838..1906110) Shigella dysenteriae Sd197 18263074 YP_403685.1 CDS insA NC_007606.1 1906920 1907195 R Code: L; COG: COG3677; insertion element iso-IS1d protein InsA complement(1906920..1907195) Shigella dysenteriae Sd197 3798859 YP_403686.1 CDS yeiK NC_007606.1 1907237 1908052 D Code: F; COG: COG1957; hypothetical protein 1907237..1908052 Shigella dysenteriae Sd197 3798860 YP_403687.1 CDS yeiJ NC_007606.1 1908152 1909402 D Code: F; COG: COG1972; transport system permease 1908152..1909402 Shigella dysenteriae Sd197 3798861 YP_403688.1 CDS yeiI NC_007606.1 1909458 1910546 R Code: G; COG: COG0524; hypothetical protein complement(1909458..1910546) Shigella dysenteriae Sd197 3798862 YP_403689.1 CDS nfo NC_007606.1 1910549 1911406 R Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV complement(1910549..1911406) Shigella dysenteriae Sd197 3798863 YP_403690.1 CDS yeiH NC_007606.1 1911480 1912529 R Code: S; COG: COG2855; hypothetical protein complement(1911480..1912529) Shigella dysenteriae Sd197 3798864 YP_403691.1 CDS yeiE NC_007606.1 1912628 1913509 D Code: K; COG: COG0583; DNA-binding transcriptional regulator 1912628..1913509 Shigella dysenteriae Sd197 3798865 YP_403692.1 CDS lysP NC_007606.1 1913714 1915183 D Code: E; COG: COG0833; lysine transporter 1913714..1915183 Shigella dysenteriae Sd197 3798866 YP_403693.1 CDS yeiG NC_007606.1 1917488 1918324 R Code: R; COG: COG0627; esterase complement(1917488..1918324) Shigella dysenteriae Sd197 3798868 YP_403694.1 CDS SDY_2113 NC_007606.1 1918252 1918536 R hypothetical protein complement(1918252..1918536) Shigella dysenteriae Sd197 3798869 YP_009000761.1 CDS SDY_4690 NC_007606.1 1918432 1918704 D insertion element iso-IS1N protein InsA 1918432..1918704 Shigella dysenteriae Sd197 18263075 YP_403696.1 CDS SDY_2115 NC_007606.1 1919220 1919627 R bacteriophage protein complement(1919220..1919627) Shigella dysenteriae Sd197 3798871 YP_403697.1 CDS SDY_2116 NC_007606.1 1919856 1920797 R bacteriophage protein complement(1919856..1920797) Shigella dysenteriae Sd197 3798872 YP_403700.1 CDS SDY_2119 NC_007606.1 1921319 1922191 R bacteriophage protein complement(1921319..1922191) Shigella dysenteriae Sd197 3798875 YP_403701.1 CDS SDY_2120 NC_007606.1 1922269 1922532 R hypothetical protein complement(1922269..1922532) Shigella dysenteriae Sd197 3798876 YP_403702.1 CDS SDY_2121 NC_007606.1 1923170 1924252 R bacteriophage protein complement(1923170..1924252) Shigella dysenteriae Sd197 3798877 YP_403703.1 CDS insB NC_007606.1 1924345 1924722 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(1924345..1924722) Shigella dysenteriae Sd197 3798878 YP_403704.1 CDS SDY_2123 NC_007606.1 1925132 1926613 D Code: P; COG: COG3119; sulfatase 1925132..1926613 Shigella dysenteriae Sd197 3798879 YP_009000762.1 CDS SDY_4691 NC_007606.1 1927144 1927416 D insertion element iso-IS1N protein InsA 1927144..1927416 Shigella dysenteriae Sd197 18263076 YP_403706.1 CDS insB NC_007606.1 1927702 1928079 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(1927702..1928079) Shigella dysenteriae Sd197 3796520 YP_403708.1 CDS folE NC_007606.1 1928844 1929512 D ''involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer''; GTP cyclohydrolase I 1928844..1929512 Shigella dysenteriae Sd197 3796522 YP_403710.1 CDS galS NC_007606.1 1930827 1931867 D galactose operon inducer; negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 1930827..1931867 Shigella dysenteriae Sd197 3796524 YP_403711.1 CDS mglB NC_007606.1 1932147 1933145 D receptor for galactose taxis; Code: G; COG: COG1879; galactose-binding transport protein 1932147..1933145 Shigella dysenteriae Sd197 3796525 YP_403713.1 CDS SDY_2132 NC_007606.1 1933756 1934151 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1933756..1934151 Shigella dysenteriae Sd197 3796527 YP_403714.1 CDS insB NC_007606.1 1935402 1935779 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1935402..1935779 Shigella dysenteriae Sd197 3796529 YP_403715.1 CDS insB NC_007606.1 1936153 1936530 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(1936153..1936530) Shigella dysenteriae Sd197 3796530 YP_403716.1 CDS insA NC_007606.1 1936575 1936850 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(1936575..1936850) Shigella dysenteriae Sd197 3796531 YP_403717.1 CDS mglC NC_007606.1 1936984 1937877 D ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein 1936984..1937877 Shigella dysenteriae Sd197 3796532 YP_403718.1 CDS SDY_2138 NC_007606.1 1938145 1938540 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1938145..1938540) Shigella dysenteriae Sd197 3796533 YP_009000763.1 CDS SDY_4692 NC_007606.1 1938567 1938839 R insertion element iso-IS1N protein InsA complement(1938567..1938839) Shigella dysenteriae Sd197 18263077 YP_009000764.1 CDS SDY_2140a NC_007606.1 1938875 1939957 R dihydropyrimidine dehydrogenase complement(1938875..1939957) Shigella dysenteriae Sd197 18263078 YP_009000765.1 CDS SDY_4693 NC_007606.1 1941264 1941536 D insertion element iso-IS1N protein InsA 1941264..1941536 Shigella dysenteriae Sd197 18263079 YP_403720.1 CDS SDY_2141 NC_007606.1 1941563 1941958 D Code: L; COG: COG1662; insertion element IS1 protein InsB 1941563..1941958 Shigella dysenteriae Sd197 3796536 YP_403721.1 CDS SDY_2142 NC_007606.1 1942157 1942396 R hypothetical protein complement(1942157..1942396) Shigella dysenteriae Sd197 3796537 YP_403722.1 CDS sanA NC_007606.1 1942399 1943118 R Code: S; COG: COG2949; hypothetical protein complement(1942399..1943118) Shigella dysenteriae Sd197 3796538 YP_403723.1 CDS cdd NC_007606.1 1943268 1944152 R Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase complement(1943268..1944152) Shigella dysenteriae Sd197 3798920 YP_403724.1 CDS yohK NC_007606.1 1944282 1944977 R Code: M; COG: COG1346; hypothetical protein complement(1944282..1944977) Shigella dysenteriae Sd197 3798921 YP_403725.1 CDS yohJ NC_007606.1 1944974 1945372 R Code: R; COG: COG1380; hypothetical protein complement(1944974..1945372) Shigella dysenteriae Sd197 3798922 YP_403727.1 CDS SDY_2148 NC_007606.1 1946879 1947274 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(1946879..1947274) Shigella dysenteriae Sd197 3798924 YP_009000766.1 CDS SDY_4694 NC_007606.1 1947301 1947573 R insertion element iso-IS1N protein InsA complement(1947301..1947573) Shigella dysenteriae Sd197 18263080 YP_403730.1 CDS yohF NC_007606.1 1949351 1950112 D Code: IQR; COG: COG1028; acetoin dehydrogenase 1949351..1950112 Shigella dysenteriae Sd197 3798927 YP_403731.1 CDS yohD NC_007606.1 1950242 1950856 R Code: S; COG: COG0586; hypothetical protein complement(1950242..1950856) Shigella dysenteriae Sd197 3798928 YP_403732.1 CDS yohC NC_007606.1 1950966 1951577 D hypothetical protein 1950966..1951577 Shigella dysenteriae Sd197 3798929 YP_403733.1 CDS pbpG NC_007606.1 1951742 1952683 D specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 1951742..1952683 Shigella dysenteriae Sd197 3798930 YP_403734.1 CDS dld NC_007606.1 1952722 1954437 R ''component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent''; D-lactate dehydrogenase complement(1952722..1954437) Shigella dysenteriae Sd197 3798931 YP_403735.1 CDS bglX NC_007606.1 1954633 1956930 D Code: G; COG: COG1472; beta-D-glucoside glucohydrolase 1954633..1956930 Shigella dysenteriae Sd197 3798932 YP_403736.1 CDS yehZ NC_007606.1 1957182 1958099 D Code: M; COG: COG1732; transport system permease 1957182..1958099 Shigella dysenteriae Sd197 3798933 YP_403737.1 CDS yehW NC_007606.1 1960183 1960914 D Code: E; COG: COG1174; transport system permease 1960183..1960914 Shigella dysenteriae Sd197 3798936 YP_403738.1 CDS SDY_2161 NC_007606.1 1960895 1961002 R hypothetical protein complement(1960895..1961002) Shigella dysenteriae Sd197 3798937 YP_403739.1 CDS yehV NC_007606.1 1961062 1961793 R Code: K; COG: COG0789; transcriptional regulator complement(1961062..1961793) Shigella dysenteriae Sd197 3798938 YP_403740.1 CDS yehU NC_007606.1 1962015 1963700 D Code: T; COG: COG3275; 2-component sensor protein 1962015..1963700 Shigella dysenteriae Sd197 3798939 YP_403741.1 CDS yehT NC_007606.1 1963682 1964416 D unknown function; when overproduced it confers drug-resistance; two-component response-regulator YehT 1963682..1964416 Shigella dysenteriae Sd197 3799228 YP_403742.1 CDS yehS NC_007606.1 1964463 1964933 D Code: S; COG: COG4807; hypothetical protein 1964463..1964933 Shigella dysenteriae Sd197 3799229 YP_403743.1 CDS yehR NC_007606.1 1964975 1965448 R Code: S; COG: COG4808; hypothetical protein complement(1964975..1965448) Shigella dysenteriae Sd197 3799230 YP_403744.1 CDS SDY_2167 NC_007606.1 1965561 1966532 R hypothetical protein complement(1965561..1966532) Shigella dysenteriae Sd197 3799231 YP_403745.2 CDS SDY_2168 NC_007606.1 1966560 1967465 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(1966560..1967465) Shigella dysenteriae Sd197 3799232 YP_403746.1 CDS SDY_2169 NC_007606.1 1967423 1967788 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(1967423..1967788) Shigella dysenteriae Sd197 3799233 YP_403747.1 CDS SDY_2170 NC_007606.1 1967830 1968921 R Code: L; COG: COG2801; hypothetical protein complement(1967830..1968921) Shigella dysenteriae Sd197 3799234 YP_009000767.1 CDS SDY_4695 NC_007606.1 1972241 1972513 D insertion element iso-IS1N protein InsA 1972241..1972513 Shigella dysenteriae Sd197 18263081 YP_403752.1 CDS SDY_2175 NC_007606.1 1972540 1972935 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1972540..1972935 Shigella dysenteriae Sd197 3799239 YP_403755.1 CDS SDY_2178 NC_007606.1 1976253 1976651 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(1976253..1976651) Shigella dysenteriae Sd197 3799242 YP_009000768.1 CDS SDY_4696 NC_007606.1 1976678 1976950 R insertion element iso-IS1N protein InsA complement(1976678..1976950) Shigella dysenteriae Sd197 18263082 YP_403756.1 CDS SDY_2179 NC_007606.1 1976986 1977411 R hypothetical protein complement(1976986..1977411) Shigella dysenteriae Sd197 3799243 YP_403757.1 CDS SDY_2180 NC_007606.1 1977371 1978459 R hypothetical protein complement(1977371..1978459) Shigella dysenteriae Sd197 3799244 YP_403758.1 CDS metG NC_007606.1 1978813 1980846 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(1978813..1980846) Shigella dysenteriae Sd197 3799245 YP_403759.2 CDS mrp NC_007606.1 1980978 1982087 D Code: D; COG: COG0489; ATPase 1980978..1982087 Shigella dysenteriae Sd197 3799246 YP_403760.1 CDS yehE NC_007606.1 1982350 1982613 D hypothetical protein 1982350..1982613 Shigella dysenteriae Sd197 3799363 YP_403761.1 CDS SDY_2184 NC_007606.1 1982665 1982967 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 1982665..1982967 Shigella dysenteriae Sd197 3799364 YP_403762.1 CDS SDY_2185 NC_007606.1 1983108 1983923 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 1983108..1983923 Shigella dysenteriae Sd197 3799365 YP_009000769.1 CDS DY_2185a NC_007606.1 1983848 1984147 R hypothetical protein complement(1983848..1984147) Shigella dysenteriae Sd197 18263083 YP_403763.1 CDS baeR NC_007606.1 1984338 1985060 R sensor BaeS; ''response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport''; DNA-binding transcriptional regulator BaeR complement(1984338..1985060) Shigella dysenteriae Sd197 3799366 YP_403764.1 CDS baeS NC_007606.1 1985057 1986460 R Code: T; COG: COG0642; signal transduction histidine-protein kinase BaeS complement(1985057..1986460) Shigella dysenteriae Sd197 3799367 YP_403765.1 CDS yegB NC_007606.1 1986354 1987400 R Code: GEPR; COG: COG0477; transport protein complement(1986354..1987400) Shigella dysenteriae Sd197 3799368 YP_403766.1 CDS SDY_2189 NC_007606.1 1987467 1988663 R Code: L; COG: COG3547; insertion element IS110 transposase complement(1987467..1988663) Shigella dysenteriae Sd197 3799369 YP_403767.1 CDS SDY_2190 NC_007606.1 1989099 1989758 D Code: R; COG: COG4245; hypothetical protein 1989099..1989758 Shigella dysenteriae Sd197 3799370 YP_403768.1 CDS SDY_2191 NC_007606.1 1989755 1990516 D hypothetical protein 1989755..1990516 Shigella dysenteriae Sd197 3799371 YP_403769.1 CDS SDY_2192 NC_007606.1 1990513 1992453 D Code: R; COG: COG4248; chaperonin 1990513..1992453 Shigella dysenteriae Sd197 3799372 YP_403770.2 CDS yegD NC_007606.1 1992465 1993817 R Code: O; COG: COG0443; chaperone complement(1992465..1993817) Shigella dysenteriae Sd197 3799373 YP_403771.1 CDS alkA NC_007606.1 1993951 1994799 D ''inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine''; 3-methyladenine DNA glycosylase 1993951..1994799 Shigella dysenteriae Sd197 3799374 YP_403772.2 CDS udk NC_007606.1 1998534 1999175 D functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1998534..1999175 Shigella dysenteriae Sd197 3799376 YP_403773.1 CDS dcd NC_007606.1 1999267 1999848 D Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1999267..1999848 Shigella dysenteriae Sd197 3799377 YP_403774.1 CDS asmA NC_007606.1 1999870 2001723 D ''YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs''; assembly protein 1999870..2001723 Shigella dysenteriae Sd197 3799378 YP_403775.1 CDS SDY_2199 NC_007606.1 2001776 2002066 R Code: S; COG: COG5606; hypothetical protein complement(2001776..2002066) Shigella dysenteriae Sd197 3799379 YP_403776.1 CDS SDY_2200 NC_007606.1 2002056 2002277 R hypothetical protein complement(2002056..2002277) Shigella dysenteriae Sd197 3799380 YP_403777.1 CDS yegH NC_007606.1 2002615 2004237 R Code: R; COG: COG1253; transport protein complement(2002615..2004237) Shigella dysenteriae Sd197 3799381 YP_009000770.1 CDS SDY_4697 NC_007606.1 2004604 2004876 D insertion element iso-IS1N protein InsA 2004604..2004876 Shigella dysenteriae Sd197 18263084 YP_403778.1 CDS SDY_2202 NC_007606.1 2004903 2005298 D Code: L; COG: COG1662; insertion element IS1 protein InsB 2004903..2005298 Shigella dysenteriae Sd197 3799382 YP_403779.1 CDS galF NC_007606.1 2005517 2006410 D ''together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose''; UTP-glucose-1-phosphate uridylyltransferase 2005517..2006410 Shigella dysenteriae Sd197 3797481 YP_403780.1 CDS rfbB NC_007606.1 2006782 2007867 D NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose; dTDP-glucose-4,6-dehydratase 2006782..2007867 Shigella dysenteriae Sd197 3797482 YP_403781.1 CDS rfbD NC_007606.1 2007867 2008766 D ''with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose''; dTDP-4-dehydrorhamnose reductase 2007867..2008766 Shigella dysenteriae Sd197 3797483 YP_403782.1 CDS rfbA NC_007606.1 2008824 2009702 D Code: M; COG: COG1209; glucose-1-phosphate thymidylyltransferase 2008824..2009702 Shigella dysenteriae Sd197 3797484 YP_403783.1 CDS rfbC NC_007606.1 2009705 2010262 D Code: M; COG: COG1898; dTDP-4-dehydrorhamnose 3,5-epimerase 2009705..2010262 Shigella dysenteriae Sd197 3797485 YP_403784.1 CDS rfbX NC_007606.1 2010259 2011449 D Code: R; COG: COG2244; O-antigen transporter 2010259..2011449 Shigella dysenteriae Sd197 3797486 YP_403785.1 CDS rfc NC_007606.1 2011446 2012588 D O-antigen polymerase 2011446..2012588 Shigella dysenteriae Sd197 3797487 YP_403786.1 CDS rfbR NC_007606.1 2012581 2013429 D rhamnosyl transferase II 2012581..2013429 Shigella dysenteriae Sd197 3797488 YP_403787.1 CDS rfbQ NC_007606.1 2013454 2014365 D rhamnosyl transferase I 2013454..2014365 Shigella dysenteriae Sd197 3797489 YP_403788.1 CDS gnd NC_007606.1 2015551 2016957 D decarboxylating; catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2015551..2016957 Shigella dysenteriae Sd197 3797490 YP_403789.1 CDS ugd NC_007606.1 2017207 2018373 D Code: M; COG: COG1004; UDP-glucose 6-dehydrogenase 2017207..2018373 Shigella dysenteriae Sd197 3797491 YP_403790.1 CDS wzzB NC_007606.1 2018463 2019497 D Code: M; COG: COG3765; O-antigen chain length regulator 2018463..2019497 Shigella dysenteriae Sd197 3797492 YP_403791.1 CDS hisI NC_007606.1 2019594 2020205 R phosphoribosyl-ATP pyrophosphatase; catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase complement(2019594..2020205) Shigella dysenteriae Sd197 3797493 YP_403792.1 CDS hisF NC_007606.1 2020199 2020975 R imidazole glycerol phsphate synthase holoenzyme; ''catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase''; imidazole glycerol phosphate synthase subunit HisF complement(2020199..2020975) Shigella dysenteriae Sd197 3797494 YP_403793.2 CDS hisA NC_007606.1 2020957 2021694 R catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase complement(2020957..2021694) Shigella dysenteriae Sd197 3797495 YP_403794.1 CDS hisH NC_007606.1 2021694 2022284 R imidazole glycerol phosphate synthase holoenzyme; ''with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide''; imidazole glycerol phosphate synthase subunit HisH complement(2021694..2022284) Shigella dysenteriae Sd197 3797496 YP_403795.2 CDS hisB NC_007606.1 2022284 2023351 R catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase complement(2022284..2023351) Shigella dysenteriae Sd197 3797497 YP_403796.1 CDS hisC NC_007606.1 2023351 2024421 R catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase complement(2023351..2024421) Shigella dysenteriae Sd197 3797498 YP_403797.1 CDS hisD NC_007606.1 2024418 2025722 R L-histidinol:NAD+ oxidoreductase; catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase complement(2024418..2025722) Shigella dysenteriae Sd197 3797499 YP_403798.1 CDS hisG NC_007606.1 2025728 2026627 R long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase complement(2025728..2026627) Shigella dysenteriae Sd197 3797143 YP_403799.1 CDS SDY_2223 NC_007606.1 2027230 2028054 D Code: MG; COG: COG0451; nucleoside-diphosphate-sugar epimerase 2027230..2028054 Shigella dysenteriae Sd197 3797144 YP_403802.1 CDS yeeF NC_007606.1 2029290 2030654 D Code: E; COG: COG0531; amino acid/amine transport protein 2029290..2030654 Shigella dysenteriae Sd197 3797147 YP_403803.2 CDS SDY_2228 NC_007606.1 2031174 2032079 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(2031174..2032079) Shigella dysenteriae Sd197 3797149 YP_403804.1 CDS SDY_2229 NC_007606.1 2032037 2032402 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(2032037..2032402) Shigella dysenteriae Sd197 3797150 YP_403805.1 CDS yeeD NC_007606.1 2033229 2033456 D Code: O; COG: COG0425; hypothetical protein 2033229..2033456 Shigella dysenteriae Sd197 3797151 YP_403806.1 CDS sbcB NC_007606.1 2033499 2034926 R 3' --> 5' specific; deoxyribophosphodiesterase; Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I complement(2033499..2034926) Shigella dysenteriae Sd197 3797152 YP_403807.1 CDS SDY_2232 NC_007606.1 2035177 2035572 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2035177..2035572) Shigella dysenteriae Sd197 3797153 YP_009000771.1 CDS SDY_4698 NC_007606.1 2035599 2035871 R insertion element iso-IS1N protein InsA complement(2035599..2035871) Shigella dysenteriae Sd197 18263085 YP_403808.1 CDS dacD NC_007606.1 2035938 2037074 D ''removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains''; D-alanyl-D-alanine carboxypeptidase 2035938..2037074 Shigella dysenteriae Sd197 3797154 YP_009000772.1 CDS SDY_4699 NC_007606.1 2037591 2037863 D insertion element iso-IS1N protein InsA 2037591..2037863 Shigella dysenteriae Sd197 18263086 YP_403809.1 CDS SDY_2235 NC_007606.1 2037890 2038285 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2037890..2038285 Shigella dysenteriae Sd197 3797156 YP_403810.1 CDS yeeA NC_007606.1 2038639 2039697 D Code: S; COG: COG1289; hypothetical protein 2038639..2039697 Shigella dysenteriae Sd197 3797157 YP_403811.1 CDS yeeX NC_007606.1 2039803 2040198 D Code: S; COG: COG2926; hypothetical protein 2039803..2040198 Shigella dysenteriae Sd197 3797158 YP_403812.1 CDS SDY_2238 NC_007606.1 2040427 2040822 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2040427..2040822) Shigella dysenteriae Sd197 3797159 YP_403813.1 CDS SDY_2239 NC_007606.1 2041017 2041358 D hypothetical protein 2041017..2041358 Shigella dysenteriae Sd197 3797160 YP_403814.1 CDS cobU NC_007606.1 2041772 2042317 D catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase 2041772..2042317 Shigella dysenteriae Sd197 3797161 YP_403815.1 CDS cobS NC_007606.1 2042314 2043057 D catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2042314..2043057 Shigella dysenteriae Sd197 3797162 YP_403816.1 CDS cobT NC_007606.1 2043069 2044148 D ''catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole''; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2043069..2044148 Shigella dysenteriae Sd197 3796976 YP_403817.1 CDS erfK NC_007606.1 2044213 2045145 D Code: S; COG: COG1376; hypothetical protein 2044213..2045145 Shigella dysenteriae Sd197 3796977 YP_403818.1 CDS nac NC_007606.1 2045602 2046519 D ''Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation''; nitrogen assimilation transcriptional regulator 2045602..2046519 Shigella dysenteriae Sd197 3796979 YP_403819.1 CDS cbl NC_007606.1 2046621 2047571 D accessory regulatory circuit affecting cysM; LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 2046621..2047571 Shigella dysenteriae Sd197 3796980 YP_403820.1 CDS SDY_2248 NC_007606.1 2048019 2048519 D hypothetical protein 2048019..2048519 Shigella dysenteriae Sd197 3796982 YP_403821.1 CDS SDY_2249 NC_007606.1 2048510 2049358 D hypothetical protein 2048510..2049358 Shigella dysenteriae Sd197 3796983 YP_403822.1 CDS insA NC_007606.1 2049619 2049894 D Code: L; COG: COG3677; insertion element IS1 protein InsA 2049619..2049894 Shigella dysenteriae Sd197 3796985 YP_403823.1 CDS insB NC_007606.1 2049939 2050316 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2049939..2050316 Shigella dysenteriae Sd197 3796986 YP_403824.1 CDS amn NC_007606.1 2050352 2051806 R Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase complement(2050352..2051806) Shigella dysenteriae Sd197 3796987 YP_403825.1 CDS shiA NC_007606.1 2051908 2053224 R Code: GEPR; COG: COG0477; shikimate transporter complement(2051908..2053224) Shigella dysenteriae Sd197 3796988 YP_403828.1 CDS SDY_2257 NC_007606.1 2054303 2054554 D Code: K; COG: COG3609; hypothetical protein 2054303..2054554 Shigella dysenteriae Sd197 3796991 YP_403829.1 CDS SDY_2258 NC_007606.1 2054574 2054852 D Code: R; COG: COG3668; plasmid stabilization protein 2054574..2054852 Shigella dysenteriae Sd197 3797026 YP_403830.1 CDS yegQ NC_007606.1 2054955 2056316 D Code: O; COG: COG0826; hypothetical protein 2054955..2056316 Shigella dysenteriae Sd197 3797027 YP_403831.1 CDS SDY_2260 NC_007606.1 2056646 2056978 R hypothetical protein complement(2056646..2056978) Shigella dysenteriae Sd197 3797028 YP_403832.1 CDS SDY_2261 NC_007606.1 2057377 2058276 D cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2057377..2058276 Shigella dysenteriae Sd197 3797029 YP_403833.1 CDS gatR NC_007606.1 2058358 2059137 R Code: KG; COG: COG1349; galactitol utilization operon repressor complement(2058358..2059137) Shigella dysenteriae Sd197 3797030 YP_403834.1 CDS gatD NC_007606.1 2059237 2060277 R Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase complement(2059237..2060277) Shigella dysenteriae Sd197 3797031 YP_403835.1 CDS gatB NC_007606.1 2061709 2061969 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB complement(2061709..2061969) Shigella dysenteriae Sd197 3797033 YP_403836.1 CDS SDY_2267 NC_007606.1 2062586 2062981 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2062586..2062981) Shigella dysenteriae Sd197 3797035 YP_009000773.1 CDS SDY_4700 NC_007606.1 2063008 2063280 R insertion element iso-IS1N protein InsA complement(2063008..2063280) Shigella dysenteriae Sd197 18263087 YP_403837.2 CDS gatY NC_007606.1 2064363 2065217 R ''catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway''; tagatose-bisphosphate aldolase complement(2064363..2065217) Shigella dysenteriae Sd197 3797037 YP_403838.2 CDS SDY_2270 NC_007606.1 2065447 2066499 R ''catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate''; fructose-bisphosphate aldolase complement(2065447..2066499) Shigella dysenteriae Sd197 3797038 YP_403839.1 CDS yegT NC_007606.1 2066756 2068033 D Code: GEPR; COG: COG0477; nucleoside permease 2066756..2068033 Shigella dysenteriae Sd197 3797039 YP_403840.1 CDS SDY_2272 NC_007606.1 2068030 2069034 D Code: O; COG: COG1397; hypothetical protein 2068030..2069034 Shigella dysenteriae Sd197 3797040 YP_403841.1 CDS SDY_2273 NC_007606.1 2069031 2069996 D Code: G; COG: COG0524; kinase 2069031..2069996 Shigella dysenteriae Sd197 3797041 YP_403842.1 CDS yegW NC_007606.1 2069970 2070716 R Code: K; COG: COG2188; transcriptional regulator complement(2069970..2070716) Shigella dysenteriae Sd197 3797042 YP_403845.1 CDS thiD NC_007606.1 2071651 2072451 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(2071651..2072451) Shigella dysenteriae Sd197 3797045 YP_403846.1 CDS thiM NC_007606.1 2072448 2073236 R catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase complement(2072448..2073236) Shigella dysenteriae Sd197 3796919 YP_403847.1 CDS yohL NC_007606.1 2073459 2073731 R Code: S; COG: COG1937; hypothetical protein complement(2073459..2073731) Shigella dysenteriae Sd197 3796920 YP_403848.1 CDS yohM NC_007606.1 2073829 2074686 D membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2073829..2074686 Shigella dysenteriae Sd197 3796921 YP_403849.2 CDS SDY_2281 NC_007606.1 2074904 2075242 D Code: S; COG: COG5455; hypothetical protein 2074904..2075242 Shigella dysenteriae Sd197 3796922 YP_009000774.1 CDS SDY_4701 NC_007606.1 2075480 2075752 D insertion element iso-IS1N protein InsA 2075480..2075752 Shigella dysenteriae Sd197 18263088 YP_403853.1 CDS SDY_2285 NC_007606.1 2076763 2077158 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2076763..2077158) Shigella dysenteriae Sd197 3796926 YP_009000775.1 CDS SDY_4702 NC_007606.1 2077185 2077457 R insertion element iso-IS1N protein InsA complement(2077185..2077457) Shigella dysenteriae Sd197 18263089 YP_403855.1 CDS yehB NC_007606.1 2077541 2079334 R Code: NU; COG: COG3188; outer membrane protein complement(2077541..2079334) Shigella dysenteriae Sd197 3796928 YP_403856.1 CDS insB NC_007606.1 2079455 2079832 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2079455..2079832) Shigella dysenteriae Sd197 3796929 YP_403857.1 CDS insA NC_007606.1 2079877 2080152 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2079877..2080152) Shigella dysenteriae Sd197 3796930 YP_403859.1 CDS SDY_2291 NC_007606.1 2080948 2081250 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(2080948..2081250) Shigella dysenteriae Sd197 3796932 YP_403860.1 CDS yceA NC_007606.1 2081395 2082447 R Code: R; COG: COG1054; hypothetical protein complement(2081395..2082447) Shigella dysenteriae Sd197 3796933 YP_403861.1 CDS htrB NC_007606.1 2082672 2083592 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 2082672..2083592 Shigella dysenteriae Sd197 3796934 YP_403864.1 CDS SDY_2296 NC_007606.1 2085138 2085440 R Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN complement(2085138..2085440) Shigella dysenteriae Sd197 3796937 YP_403865.1 CDS yceE NC_007606.1 2085936 2086907 D Code: GEPR; COG: COG0477; transport protein 2085936..2086907 Shigella dysenteriae Sd197 3798177 YP_403866.1 CDS SDY_2298 NC_007606.1 2086862 2086960 D hypothetical protein 2086862..2086960 Shigella dysenteriae Sd197 3798178 YP_403867.1 CDS msyB NC_007606.1 2086987 2087364 D suppresses mutants lacking function of protein export; hypothetical protein 2086987..2087364 Shigella dysenteriae Sd197 3798179 YP_403868.1 CDS yceK NC_007606.1 2087365 2087592 R Code: R; COG: COG5645; hypothetical protein complement(2087365..2087592) Shigella dysenteriae Sd197 3798180 YP_403869.1 CDS mdoH NC_007606.1 2087765 2090308 R synthesis of membrane-derived oligosaccharide (MDO); necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH complement(2087765..2090308) Shigella dysenteriae Sd197 3798181 YP_403870.1 CDS mdoG NC_007606.1 2090301 2091836 R involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G complement(2090301..2091836) Shigella dysenteriae Sd197 3798182 YP_403871.1 CDS mdoC NC_007606.1 2092230 2093387 D required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 2092230..2093387 Shigella dysenteriae Sd197 3798183 YP_403872.1 CDS ymdC NC_007606.1 2093395 2094876 R Code: I; COG: COG1502; synthase complement(2093395..2094876) Shigella dysenteriae Sd197 3798184 YP_403873.1 CDS SDY_2305 NC_007606.1 2094818 2095351 R Code: R; COG: COG2110; hypothetical protein complement(2094818..2095351) Shigella dysenteriae Sd197 3798185 YP_403874.1 CDS SDY_2306 NC_007606.1 2095446 2095757 R hypothetical protein complement(2095446..2095757) Shigella dysenteriae Sd197 3798186 YP_403875.1 CDS insA NC_007606.1 2096116 2096391 D Code: L; COG: COG3677; insertion element IS1 protein InsA 2096116..2096391 Shigella dysenteriae Sd197 3798187 YP_403876.1 CDS insB NC_007606.1 2096436 2096813 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2096436..2096813 Shigella dysenteriae Sd197 3798188 YP_403879.1 CDS yceI NC_007606.1 2097982 2098569 R Code: S; COG: COG2353; hypothetical protein complement(2097982..2098569) Shigella dysenteriae Sd197 3798191 YP_403880.1 CDS SDY_2312 NC_007606.1 2098573 2099139 R Code: C; COG: COG3038; cytochrome complement(2098573..2099139) Shigella dysenteriae Sd197 3798192 YP_403881.1 CDS SDY_2313 NC_007606.1 2099117 2099380 R hypothetical protein complement(2099117..2099380) Shigella dysenteriae Sd197 3798193 YP_009000776.1 CDS SDY_4703 NC_007606.1 2099276 2099548 D insertion element iso-IS1N protein InsA 2099276..2099548 Shigella dysenteriae Sd197 18263090 YP_403882.1 CDS SDY_2314 NC_007606.1 2099575 2099970 D Code: L; COG: COG1662; insertion element IS1 protein InsB 2099575..2099970 Shigella dysenteriae Sd197 3798194 YP_403883.1 CDS fruA NC_007606.1 2100400 2102091 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunit IIBC complement(2100400..2102091) Shigella dysenteriae Sd197 3798195 YP_403884.1 CDS fruK NC_007606.1 2102108 2103046 R ''converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers''; 1-phosphofructokinase complement(2102108..2103046) Shigella dysenteriae Sd197 3798196 YP_403885.1 CDS fruB NC_007606.1 2103046 2104176 R ''phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr''; bifunctional fructose-specific PTS IIA/HPr protein complement(2103046..2104176) Shigella dysenteriae Sd197 3795616 YP_403886.1 CDS SDY_2318 NC_007606.1 2104448 2104843 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2104448..2104843) Shigella dysenteriae Sd197 3795617 YP_009000777.1 CDS SDY_4704 NC_007606.1 2104870 2105142 R insertion element iso-IS1N protein InsA complement(2104870..2105142) Shigella dysenteriae Sd197 18263091 YP_403887.1 CDS ycbP NC_007606.1 2105310 2105885 D Code: R; COG: COG0431; NAD(P)H-dependent FMN reductase 2105310..2105885 Shigella dysenteriae Sd197 3795618 YP_403888.1 CDS ycbO NC_007606.1 2105878 2106870 D part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 2105878..2106870 Shigella dysenteriae Sd197 3795619 YP_403891.1 CDS ssuC NC_007606.1 2107845 2108636 D part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease 2107845..2108636 Shigella dysenteriae Sd197 3795622 YP_403893.1 CDS pepN NC_007606.1 2109427 2112039 R Code: E; COG: COG0308; aminopeptidase complement(2109427..2112039) Shigella dysenteriae Sd197 3795624 YP_403894.1 CDS pncB NC_007606.1 2112305 2113507 D catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 2112305..2113507 Shigella dysenteriae Sd197 3795625 YP_403895.1 CDS asnC NC_007606.1 2113677 2115077 D ''catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''; asparaginyl-tRNA synthetase 2113677..2115077 Shigella dysenteriae Sd197 3795626 YP_403896.1 CDS ompF NC_007606.1 2115680 2116768 D outer membrane porin F; 1a; Ia; b; outer membrane protein F 2115680..2116768 Shigella dysenteriae Sd197 3795627 YP_403897.1 CDS aspC NC_007606.1 2116953 2118143 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 2116953..2118143 Shigella dysenteriae Sd197 3795628 YP_403898.1 CDS ycbL NC_007606.1 2118193 2118840 R Code: R; COG: COG0491; hypothetical protein complement(2118193..2118840) Shigella dysenteriae Sd197 3795629 YP_403899.1 CDS ycbK NC_007606.1 2118867 2119415 R Code: S; COG: COG3108; hypothetical protein complement(2118867..2119415) Shigella dysenteriae Sd197 3795630 YP_403900.1 CDS ycbB NC_007606.1 2119596 2121443 R Code: S; COG: COG2989; hypothetical protein complement(2119596..2121443) Shigella dysenteriae Sd197 3795631 YP_403901.1 CDS SDY_2333 NC_007606.1 2121629 2122024 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2121629..2122024) Shigella dysenteriae Sd197 3795632 YP_009000778.1 CDS SDY_4705 NC_007606.1 2122051 2122323 R insertion element iso-IS1N protein InsA complement(2122051..2122323) Shigella dysenteriae Sd197 18263092 YP_403902.1 CDS mukB NC_007606.1 2122426 2126877 R SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB complement(2122426..2126877) Shigella dysenteriae Sd197 3795633 YP_403903.1 CDS mukE NC_007606.1 2126877 2127554 R acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E complement(2126877..2127554) Shigella dysenteriae Sd197 3795634 YP_403904.1 CDS mukF NC_007606.1 2127562 2128884 R killing factor KICB; acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F complement(2127562..2128884) Shigella dysenteriae Sd197 3795425 YP_403905.1 CDS smtA NC_007606.1 2128881 2129666 R involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA complement(2128881..2129666) Shigella dysenteriae Sd197 3795426 YP_403906.1 CDS ycbC NC_007606.1 2129804 2130583 D Code: S; COG: COG1434; hypothetical protein 2129804..2130583 Shigella dysenteriae Sd197 3795427 YP_403907.1 CDS SDY_2339 NC_007606.1 2130560 2131453 R hypothetical protein complement(2130560..2131453) Shigella dysenteriae Sd197 3795428 YP_403908.1 CDS kdsB NC_007606.1 2131607 2132353 R CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase complement(2131607..2132353) Shigella dysenteriae Sd197 3795429 YP_403909.1 CDS ycaR NC_007606.1 2132350 2132532 R Code: S; COG: COG2835; hypothetical protein complement(2132350..2132532) Shigella dysenteriae Sd197 3795430 YP_403910.1 CDS ycaQ NC_007606.1 2132584 2133816 R Code: S; COG: COG3214; hypothetical protein complement(2132584..2133816) Shigella dysenteriae Sd197 3795431 YP_403911.1 CDS lpxK NC_007606.1 2133853 2134839 R ''transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate''; tetraacyldisaccharide 4'-kinase complement(2133853..2134839) Shigella dysenteriae Sd197 3795432 YP_403912.1 CDS msbA NC_007606.1 2134836 2136584 R multicopy suppressor of htrB; involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease complement(2134836..2136584) Shigella dysenteriae Sd197 3795433 YP_403913.2 CDS ycaI NC_007606.1 2136621 2138885 R Code: R; COG: COG0658; hypothetical protein complement(2136621..2138885) Shigella dysenteriae Sd197 3795434 YP_403914.1 CDS ihfB NC_007606.1 2139092 2139376 R IHF; site-specific recombination; ''This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control''; integration host factor subunit beta complement(2139092..2139376) Shigella dysenteriae Sd197 3795435 YP_403915.1 CDS rpsA NC_007606.1 2139536 2141209 R in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 complement(2139536..2141209) Shigella dysenteriae Sd197 3795436 YP_403916.1 CDS cmk NC_007606.1 2141320 2142003 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(2141320..2142003) Shigella dysenteriae Sd197 3795437 YP_403917.1 CDS ycaL NC_007606.1 2142176 2142940 R Code: O; COG: COG0501; heat shock protein complement(2142176..2142940) Shigella dysenteriae Sd197 3795438 YP_403918.1 CDS SDY_2350 NC_007606.1 2142994 2143404 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 2142994..2143404 Shigella dysenteriae Sd197 3795439 YP_403919.2 CDS SDY_2351 NC_007606.1 2143362 2144267 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2143362..2144267 Shigella dysenteriae Sd197 3795440 YP_403920.1 CDS SDY_2352 NC_007606.1 2144465 2145811 D Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG 2144465..2145811 Shigella dysenteriae Sd197 3795441 YP_403921.1 CDS aroA NC_007606.1 2145893 2147167 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(2145893..2147167) Shigella dysenteriae Sd197 3795442 YP_403922.1 CDS serC NC_007606.1 2147238 2148326 R catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase complement(2147238..2148326) Shigella dysenteriae Sd197 3795443 YP_403923.1 CDS ycaP NC_007606.1 2148525 2149217 R Code: S; COG: COG2323; hypothetical protein complement(2148525..2149217) Shigella dysenteriae Sd197 3795444 YP_403925.1 CDS focA NC_007606.1 2151514 2152371 D formate channel 1; Code: P; COG: COG2116; formate transporter 2151514..2152371 Shigella dysenteriae Sd197 3795965 YP_403926.1 CDS pflB NC_007606.1 2152426 2154708 D Code: C; COG: COG1882; formate acetyltransferase 1 2152426..2154708 Shigella dysenteriae Sd197 3795966 YP_403927.1 CDS pflA NC_007606.1 2154900 2155640 D activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 2154900..2155640 Shigella dysenteriae Sd197 3795967 YP_009000779.1 CDS SDY_4706 NC_007606.1 2156213 2156485 D insertion element iso-IS1N protein InsA 2156213..2156485 Shigella dysenteriae Sd197 18263093 YP_403928.2 CDS SDY_2360 NC_007606.1 2156512 2156907 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2156512..2156907 Shigella dysenteriae Sd197 3795968 YP_403929.1 CDS SDY_2361 NC_007606.1 2158741 2159043 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(2158741..2159043) Shigella dysenteriae Sd197 3795969 YP_403930.1 CDS ycaD NC_007606.1 2159533 2160681 R Code: GEPR; COG: COG0477; MFS family transporter protein complement(2159533..2160681) Shigella dysenteriae Sd197 3795971 YP_403932.1 CDS dmsC NC_007606.1 2161658 2162521 R Code: R; COG: COG3302; anaerobic dimethyl sulfoxide reductase subunit C complement(2161658..2162521) Shigella dysenteriae Sd197 3795973 YP_403933.1 CDS dmsA NC_007606.1 2163150 2165507 R Code: C; COG: COG0243; anaerobic dimethyl sulfoxide reductase subunit A complement(2163150..2165507) Shigella dysenteriae Sd197 3795975 YP_403934.1 CDS serS NC_007606.1 2165833 2167125 R ''catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''; seryl-tRNA synthetase complement(2165833..2167125) Shigella dysenteriae Sd197 3795976 YP_403935.1 CDS ycaJ NC_007606.1 2167216 2168559 R Code: L; COG: COG2256; recombination factor protein RarA complement(2167216..2168559) Shigella dysenteriae Sd197 3795977 YP_403936.1 CDS lolA NC_007606.1 2168570 2169184 R participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein complement(2168570..2169184) Shigella dysenteriae Sd197 3795978 YP_403937.1 CDS ftsK NC_007606.1 2169336 2173442 R DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK complement(2169336..2173442) Shigella dysenteriae Sd197 3795979 YP_403938.1 CDS lrp NC_007606.1 2173577 2174071 R mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator complement(2173577..2174071) Shigella dysenteriae Sd197 3795980 YP_403939.1 CDS trxB NC_007606.1 2174616 2175581 D catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 2174616..2175581 Shigella dysenteriae Sd197 3795981 YP_403940.1 CDS cydD NC_007606.1 2175704 2177470 D in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 2175704..2177470 Shigella dysenteriae Sd197 3795982 YP_403941.1 CDS cydC NC_007606.1 2177471 2179192 D in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 2177471..2179192 Shigella dysenteriae Sd197 3798901 YP_403942.1 CDS aat NC_007606.1 2179234 2179938 D ''leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys''; leucyl/phenylalanyl-tRNA--protein transferase 2179234..2179938 Shigella dysenteriae Sd197 3798902 YP_403943.1 CDS infA NC_007606.1 2180223 2180441 D ''stimulates the activities of the other two initiation factors, IF-2 and IF-3''; translation initiation factor IF-1 2180223..2180441 Shigella dysenteriae Sd197 3798903 YP_403944.1 CDS clpA NC_007606.1 2181125 2183401 R ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit complement(2181125..2183401) Shigella dysenteriae Sd197 3798905 YP_403945.1 CDS clpS NC_007606.1 2183431 2183751 R involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS complement(2183431..2183751) Shigella dysenteriae Sd197 3798906 YP_403946.1 CDS cspD NC_007606.1 2184074 2184298 D inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 2184074..2184298 Shigella dysenteriae Sd197 3798907 YP_403947.1 CDS ybjZ NC_007606.1 2184371 2186323 R with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease complement(2184371..2186323) Shigella dysenteriae Sd197 3798908 YP_403948.2 CDS SDY_2383 NC_007606.1 2186320 2187369 R confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA complement(2186320..2187369) Shigella dysenteriae Sd197 3798909 YP_403949.1 CDS ybjX NC_007606.1 2187484 2188476 D Code: S; COG: COG2990; hypothetical protein 2187484..2188476 Shigella dysenteriae Sd197 3798910 YP_403950.1 CDS ybjD NC_007606.1 2188473 2190131 R Code: L; COG: COG3593; hypothetical protein complement(2188473..2190131) Shigella dysenteriae Sd197 3798911 YP_403951.1 CDS insB NC_007606.1 2190304 2190681 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2190304..2190681) Shigella dysenteriae Sd197 3798912 YP_403952.1 CDS insA NC_007606.1 2190726 2191001 R Code: L; COG: COG3677; insertion element iso-IS1d protein InsA complement(2190726..2191001) Shigella dysenteriae Sd197 3798913 YP_403953.1 CDS aqpZ NC_007606.1 2191334 2192011 D porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 2191334..2192011 Shigella dysenteriae Sd197 3798914 YP_403954.1 CDS ybjE NC_007606.1 2192145 2193044 D Code: S; COG: COG2431; surface protein 2192145..2193044 Shigella dysenteriae Sd197 3798915 YP_403955.2 CDS ybjW NC_007606.1 2193188 2194840 D catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 2193188..2194840 Shigella dysenteriae Sd197 3798916 YP_403956.1 CDS SDY_2391 NC_007606.1 2194852 2195820 D Code: C; COG: COG1018; HCP oxidoreductase 2194852..2195820 Shigella dysenteriae Sd197 3798917 YP_403957.1 CDS poxB NC_007606.1 2195953 2197671 D catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 2195953..2197671 Shigella dysenteriae Sd197 3798918 YP_403958.1 CDS ybjU NC_007606.1 2197708 2198709 D ''low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine''; L-threonine aldolase 2197708..2198709 Shigella dysenteriae Sd197 3798919 YP_403959.1 CDS ybjT NC_007606.1 2198720 2200150 D Code: MG; COG: COG0702; dTDP-glucose enzyme 2198720..2200150 Shigella dysenteriae Sd197 3797969 YP_403960.1 CDS SDY_2395 NC_007606.1 2200213 2201262 D Code: MG; COG: COG0451; nucleotide di-P-sugar epimerase or dehydratase 2200213..2201262 Shigella dysenteriae Sd197 3797970 YP_403961.1 CDS SDY_2396 NC_007606.1 2201259 2202089 R Code: V; COG: COG3023; regulator complement(2201259..2202089) Shigella dysenteriae Sd197 3797971 YP_403962.1 CDS SDY_2397 NC_007606.1 2202086 2202409 R Code: S; COG: COG0393; hypothetical protein complement(2202086..2202409) Shigella dysenteriae Sd197 3797972 YP_403963.1 CDS insA NC_007606.1 2203083 2203358 D Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 2203083..2203358 Shigella dysenteriae Sd197 3797973 YP_009000780.1 CDS SDY_2398a NC_007606.1 2203403 2203780 D transposase IS1 2203403..2203780 Shigella dysenteriae Sd197 18263094 YP_403965.1 CDS SDY_2400 NC_007606.1 2204333 2204728 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2204333..2204728) Shigella dysenteriae Sd197 3797975 YP_009000781.1 CDS SDY_4707 NC_007606.1 2204755 2205027 R insertion element iso-IS1N protein InsA complement(2204755..2205027) Shigella dysenteriae Sd197 18263095 YP_403966.1 CDS SDY_2401 NC_007606.1 2205067 2205846 R hypothetical protein complement(2205067..2205846) Shigella dysenteriae Sd197 3797976 YP_009000782.1 CDS SDY_4708 NC_007606.1 2206170 2206442 D insertion element iso-IS1N protein InsA 2206170..2206442 Shigella dysenteriae Sd197 18263096 YP_403967.1 CDS SDY_2402 NC_007606.1 2206469 2206864 D Code: L; COG: COG1662; insertion element IS1 protein InsB 2206469..2206864 Shigella dysenteriae Sd197 3797977 YP_403969.1 CDS artP NC_007606.1 2208003 2208731 D With ArtMQJI transports arginine across the inner membrane; arginine ABC transporter ATP-binding protein 2208003..2208731 Shigella dysenteriae Sd197 3797979 YP_403970.1 CDS artI NC_007606.1 2208749 2209480 D Code: ET; COG: COG0834; arginine ABC transporter substrate-binding protein 2208749..2209480 Shigella dysenteriae Sd197 3797980 YP_403971.1 CDS artQ NC_007606.1 2209487 2210203 D with ArtPMJI transports arginine across the inner membrane; arginine ABC transporter permease ArtQ 2209487..2210203 Shigella dysenteriae Sd197 3797981 YP_403972.1 CDS artM NC_007606.1 2210203 2210871 D with ArtPQJI acts to transport arginine across the inner membrane; arginine ABC transporter permease ArtM 2210203..2210871 Shigella dysenteriae Sd197 3797982 YP_403974.1 CDS SDY_2410 NC_007606.1 2211710 2212519 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(2211710..2212519) Shigella dysenteriae Sd197 3797985 YP_403975.1 CDS SDY_2411 NC_007606.1 2212660 2212962 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(2212660..2212962) Shigella dysenteriae Sd197 3797986 YP_009000783.1 CDS SDY_4709 NC_007606.1 2213189 2213461 R insertion element iso-IS1N protein InsA complement(2213189..2213461) Shigella dysenteriae Sd197 18263097 YP_403978.1 CDS SDY_2414 NC_007606.1 2213696 2214424 R Code: S; COG: COG3645; DNA-binding protein Roi of bacteriophage BP-933W complement(2213696..2214424) Shigella dysenteriae Sd197 3797408 YP_403979.2 CDS SDY_2415 NC_007606.1 2214493 2215170 R Code: K; COG: COG3561; antirepressor protein complement(2214493..2215170) Shigella dysenteriae Sd197 3797409 YP_403980.1 CDS SDY_2416 NC_007606.1 2215810 2216118 D hypothetical protein 2215810..2216118 Shigella dysenteriae Sd197 3797410 YP_403981.1 CDS ninB NC_007606.1 2216333 2216743 R recombination protein complement(2216333..2216743) Shigella dysenteriae Sd197 3797411 YP_403982.1 CDS SDY_2418 NC_007606.1 2216796 2217584 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(2216796..2217584) Shigella dysenteriae Sd197 3797412 YP_403983.1 CDS SDY_2419 NC_007606.1 2217725 2218027 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(2217725..2218027) Shigella dysenteriae Sd197 3797413 YP_403984.1 CDS SDY_2420 NC_007606.1 2218110 2219165 D Code: L; COG: COG0582; integrase 2218110..2219165 Shigella dysenteriae Sd197 3797414 YP_403985.1 CDS SDY_2421 NC_007606.1 2219223 2219783 R Code: S; COG: COG3234; hypothetical protein complement(2219223..2219783) Shigella dysenteriae Sd197 3797415 YP_403986.1 CDS SDY_2422 NC_007606.1 2219780 2220256 R hypothetical protein complement(2219780..2220256) Shigella dysenteriae Sd197 3797416 YP_403987.1 CDS gyrA NC_007606.1 2220357 2222984 R type II topoisomerase; negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(2220357..2222984) Shigella dysenteriae Sd197 3797417 YP_403988.1 CDS ubiG NC_007606.1 2223131 2223853 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2223131..2223853 Shigella dysenteriae Sd197 3797418 YP_403992.1 CDS nrdA NC_007606.1 2228442 2230727 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2228442..2230727 Shigella dysenteriae Sd197 3797422 YP_403993.1 CDS nrdB NC_007606.1 2230873 2232003 D B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2230873..2232003 Shigella dysenteriae Sd197 3797423 YP_403994.1 CDS yfaE NC_007606.1 2232003 2232257 D ''plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases''; 2Fe-2S ferredoxin 2232003..2232257 Shigella dysenteriae Sd197 3797424 YP_403996.1 CDS SDY_2432 NC_007606.1 2233042 2234232 R Code: GEPR; COG: COG0477; antibiotic resistance protein complement(2233042..2234232) Shigella dysenteriae Sd197 3797426 YP_403998.1 CDS glpQ NC_007606.1 2235313 2236392 R hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase complement(2235313..2236392) Shigella dysenteriae Sd197 3798235 YP_403999.1 CDS glpT NC_007606.1 2236397 2237755 R catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter complement(2236397..2237755) Shigella dysenteriae Sd197 3798236 YP_404000.1 CDS glpA NC_007606.1 2238028 2239656 D ''anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor''; sn-glycerol-3-phosphate dehydrogenase subunit A 2238028..2239656 Shigella dysenteriae Sd197 3798237 YP_404001.1 CDS glpB NC_007606.1 2239646 2240905 D sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2239646..2240905 Shigella dysenteriae Sd197 3798238 YP_404002.1 CDS glpC NC_007606.1 2240902 2242092 D anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2240902..2242092 Shigella dysenteriae Sd197 3798239 YP_404003.1 CDS yfaD NC_007606.1 2242285 2243211 D Code: S; COG: COG5464; hypothetical protein 2242285..2243211 Shigella dysenteriae Sd197 3798240 YP_404004.1 CDS SDY_2440 NC_007606.1 2243252 2244055 R Code: G; COG: COG3836; aldolase complement(2243252..2244055) Shigella dysenteriae Sd197 3798241 YP_009000784.1 CDS SDY_2440a NC_007606.1 2245207 2245482 D transposase IS1 2245207..2245482 Shigella dysenteriae Sd197 18263098 YP_404005.1 CDS insB NC_007606.1 2245527 2245904 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2245527..2245904 Shigella dysenteriae Sd197 3798243 YP_404007.1 CDS insA NC_007606.1 2247649 2247924 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2247649..2247924) Shigella dysenteriae Sd197 3798246 YP_404010.1 CDS SDY_2448 NC_007606.1 2249008 2249403 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2249008..2249403 Shigella dysenteriae Sd197 3798249 YP_404011.1 CDS SDY_2449 NC_007606.1 2249487 2250014 D hypothetical protein 2249487..2250014 Shigella dysenteriae Sd197 3798250 YP_404014.1 CDS SDY_2452 NC_007606.1 2252964 2253854 D Code: G; COG: COG0726; hypothetical protein 2252964..2253854 Shigella dysenteriae Sd197 3797275 YP_404015.1 CDS arnT NC_007606.1 2253854 2255506 D catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2253854..2255506 Shigella dysenteriae Sd197 3797276 YP_404016.2 CDS SDY_2454 NC_007606.1 2255838 2256224 D Code: GER; COG: COG0697; hypothetical protein 2255838..2256224 Shigella dysenteriae Sd197 3797277 YP_404017.1 CDS pmrD NC_007606.1 2256252 2256512 R polymyxin resistance protein B complement(2256252..2256512) Shigella dysenteriae Sd197 3797278 YP_404018.1 CDS menE NC_007606.1 2256592 2257947 R Code: IQ; COG: COG0318; O-succinylbenzoic acid--CoA ligase complement(2256592..2257947) Shigella dysenteriae Sd197 3797279 YP_404019.1 CDS menC NC_007606.1 2257944 2258906 R conversion of chorismate to 2-o-succinylbenzoyl-CoA; ''catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate''; O-succinylbenzoate synthase complement(2257944..2258906) Shigella dysenteriae Sd197 3797280 YP_404020.1 CDS menB NC_007606.1 2258906 2259763 R ''catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA''; naphthoate synthase complement(2258906..2259763) Shigella dysenteriae Sd197 3797281 YP_404021.1 CDS yfbB NC_007606.1 2259778 2260536 R catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase complement(2259778..2260536) Shigella dysenteriae Sd197 3797282 YP_404022.1 CDS menD NC_007606.1 2260533 2262203 R SHCHC synthase; SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase complement(2260533..2262203) Shigella dysenteriae Sd197 3797283 YP_404023.2 CDS menF NC_007606.1 2262292 2263587 R Code: HQ; COG: COG1169; isochorismate hydroxymutase complement(2262292..2263587) Shigella dysenteriae Sd197 3797284 YP_404024.1 CDS elaB NC_007606.1 2263666 2263971 R Code: S; COG: COG4575; hypothetical protein complement(2263666..2263971) Shigella dysenteriae Sd197 3797285 YP_404025.1 CDS elaA NC_007606.1 2264026 2264487 R Code: R; COG: COG2153; hypothetical protein complement(2264026..2264487) Shigella dysenteriae Sd197 3797286 YP_404026.2 CDS elaC NC_007606.1 2264552 2265469 D member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2264552..2265469 Shigella dysenteriae Sd197 3797287 YP_404027.1 CDS insA NC_007606.1 2266277 2266552 D Code: L; COG: COG3677; insertion element IS1 protein InsA 2266277..2266552 Shigella dysenteriae Sd197 3797289 YP_404028.1 CDS insB NC_007606.1 2266597 2266974 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2266597..2266974 Shigella dysenteriae Sd197 3797290 YP_009000785.1 CDS SDY_4710 NC_007606.1 2267333 2267605 R insertion element iso-IS1N protein InsA complement(2267333..2267605) Shigella dysenteriae Sd197 18263099 YP_009000786.1 CDS SDY_4711 NC_007606.1 2268084 2268356 D insertion element iso-IS1N protein InsA 2268084..2268356 Shigella dysenteriae Sd197 18263100 YP_404030.1 CDS SDY_2469 NC_007606.1 2268383 2268778 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2268383..2268778 Shigella dysenteriae Sd197 3797292 YP_404032.1 CDS yfbM NC_007606.1 2269166 2269669 D hypothetical protein 2269166..2269669 Shigella dysenteriae Sd197 3797294 YP_404033.2 CDS nuoN NC_007606.1 2269736 2271193 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N complement(2269736..2271193) Shigella dysenteriae Sd197 3797592 YP_404034.1 CDS nuoM NC_007606.1 2271200 2272729 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M complement(2271200..2272729) Shigella dysenteriae Sd197 3797593 YP_404035.1 CDS nuoL NC_007606.1 2272960 2274801 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L complement(2272960..2274801) Shigella dysenteriae Sd197 3797594 YP_404036.1 CDS nuoK NC_007606.1 2274798 2275100 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K complement(2274798..2275100) Shigella dysenteriae Sd197 3797595 YP_404037.1 CDS nuoJ NC_007606.1 2275097 2275651 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J complement(2275097..2275651) Shigella dysenteriae Sd197 3797596 YP_404038.1 CDS nuoI NC_007606.1 2275663 2276205 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(2275663..2276205) Shigella dysenteriae Sd197 3797597 YP_404039.1 CDS nuoH NC_007606.1 2276220 2277197 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(2276220..2277197) Shigella dysenteriae Sd197 3797598 YP_404040.1 CDS nuoG NC_007606.1 2277194 2279926 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(2277194..2279926) Shigella dysenteriae Sd197 3797599 YP_404041.1 CDS nuoF NC_007606.1 2279973 2281310 R ''shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase''; NADH dehydrogenase I subunit F complement(2279973..2281310) Shigella dysenteriae Sd197 3797600 YP_404042.1 CDS nuoE NC_007606.1 2281307 2281807 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(2281307..2281807) Shigella dysenteriae Sd197 3797601 YP_404043.1 CDS nuoC NC_007606.1 2281810 2283612 R ''NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms''; bifunctional NADH:ubiquinone oxidoreductase subunit C/D complement(2281810..2283612) Shigella dysenteriae Sd197 3797602 YP_404044.1 CDS nuoB NC_007606.1 2283706 2284368 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(2283706..2284368) Shigella dysenteriae Sd197 3797603 YP_404045.1 CDS nuoA NC_007606.1 2284384 2284827 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A complement(2284384..2284827) Shigella dysenteriae Sd197 3797604 YP_404046.1 CDS lrhA NC_007606.1 2285459 2286397 R Code: K; COG: COG0583; LysR family transcriptional regulator complement(2285459..2286397) Shigella dysenteriae Sd197 3797605 YP_404047.1 CDS SDY_2486 NC_007606.1 2287311 2288528 D ''broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor''; aminotransferase 2287311..2288528 Shigella dysenteriae Sd197 3797606 YP_404048.1 CDS SDY_2487 NC_007606.1 2288612 2289211 D Code: R; COG: COG1896; hypothetical protein 2288612..2289211 Shigella dysenteriae Sd197 3797607 YP_404049.1 CDS yfbS NC_007606.1 2289270 2291102 R Code: P; COG: COG0471; transport protein complement(2289270..2291102) Shigella dysenteriae Sd197 3797608 YP_404050.1 CDS yfbT NC_007606.1 2291189 2291839 R Code: R; COG: COG0637; phosphatase complement(2291189..2291839) Shigella dysenteriae Sd197 3797609 YP_404051.2 CDS SDY_2490 NC_007606.1 2291850 2292344 R Code: S; COG: COG3013; hypothetical protein complement(2291850..2292344) Shigella dysenteriae Sd197 3797610 YP_404052.1 CDS SDY_2491 NC_007606.1 2292427 2292882 R Code: S; COG: COG3092; hypothetical protein complement(2292427..2292882) Shigella dysenteriae Sd197 3799537 YP_404053.1 CDS ackA NC_007606.1 2293220 2294422 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2293220..2294422 Shigella dysenteriae Sd197 3799538 YP_404054.1 CDS pta NC_007606.1 2294497 2296641 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2294497..2296641 Shigella dysenteriae Sd197 3799539 YP_404055.2 CDS yfcC NC_007606.1 2296831 2298351 D Code: S; COG: COG1288; hypothetical protein 2296831..2298351 Shigella dysenteriae Sd197 3799540 YP_404056.1 CDS SDY_2495 NC_007606.1 2298384 2298926 R Code: LR; COG: COG0494; regulator complement(2298384..2298926) Shigella dysenteriae Sd197 3799541 YP_404057.1 CDS yfcE NC_007606.1 2298984 2299538 R Code: R; COG: COG0622; phosphodiesterase complement(2298984..2299538) Shigella dysenteriae Sd197 3799542 YP_404060.1 CDS yfcG NC_007606.1 2300371 2301018 D Code: O; COG: COG0625; glutathione S-transferase 2300371..2301018 Shigella dysenteriae Sd197 3799545 YP_404061.1 CDS folX NC_007606.1 2301075 2301437 D catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2301075..2301437 Shigella dysenteriae Sd197 3799546 YP_404062.1 CDS SDY_2501 NC_007606.1 2301458 2302351 D Code: R; COG: COG1090; sugar nucleotide epimerase 2301458..2302351 Shigella dysenteriae Sd197 3799547 YP_404063.1 CDS yfcI NC_007606.1 2302399 2303019 R Code: S; COG: COG5464; hypothetical protein complement(2302399..2303019) Shigella dysenteriae Sd197 3799548 YP_404066.1 CDS hisP NC_007606.1 2304242 2305015 R Code: E; COG: COG4598; histidine/lysine/arginine/ornithine transporter protein complement(2304242..2305015) Shigella dysenteriae Sd197 3799551 YP_404067.1 CDS hisM NC_007606.1 2305023 2305739 R Code: E; COG: COG4160; histidine transport system protein M complement(2305023..2305739) Shigella dysenteriae Sd197 3799552 YP_404068.1 CDS hisQ NC_007606.1 2305736 2306422 R Code: E; COG: COG4215; histidine transport system permease complement(2305736..2306422) Shigella dysenteriae Sd197 3799553 YP_404069.1 CDS hisJ NC_007606.1 2306512 2307294 R Code: ET; COG: COG0834; high-affinity histidine transport system substrate-binding protein complement(2306512..2307294) Shigella dysenteriae Sd197 3799554 YP_404070.1 CDS argT NC_007606.1 2307515 2308297 R Code: ET; COG: COG0834; lysine-, arginine-, ornithine-binding periplasmic protein complement(2307515..2308297) Shigella dysenteriae Sd197 3799555 YP_404071.1 CDS ubiX NC_007606.1 2308562 2309131 R catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(2308562..2309131) Shigella dysenteriae Sd197 3799556 YP_404072.1 CDS purF NC_007606.1 2309226 2310743 R PRPP amidotransferase; Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(2309226..2310743) Shigella dysenteriae Sd197 3797651 YP_404073.1 CDS cvpA NC_007606.1 2310780 2311268 R membrane protein required for colicin V production; colicin V production protein complement(2310780..2311268) Shigella dysenteriae Sd197 3797652 YP_404074.2 CDS dedD NC_007606.1 2311709 2312371 R Code: S; COG: COG3147; hypothetical protein complement(2311709..2312371) Shigella dysenteriae Sd197 3797653 YP_404075.1 CDS folC NC_007606.1 2312361 2313629 R dihydrofolate synthetase; Code: H; COG: COG0285; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase complement(2312361..2313629) Shigella dysenteriae Sd197 3797654 YP_404076.1 CDS accD NC_007606.1 2313699 2314613 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(2313699..2314613) Shigella dysenteriae Sd197 3797655 YP_404077.1 CDS dedA NC_007606.1 2314769 2315428 R Code: S; COG: COG0586; hypothetical protein complement(2314769..2315428) Shigella dysenteriae Sd197 3797656 YP_404078.1 CDS truA NC_007606.1 2315511 2316323 R ''mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability''; tRNA pseudouridine synthase A complement(2315511..2316323) Shigella dysenteriae Sd197 3797657 YP_404079.1 CDS usg NC_007606.1 2316323 2317336 R Code: E; COG: COG0136; semialdehyde dehydrogenase complement(2316323..2317336) Shigella dysenteriae Sd197 3797658 YP_404080.1 CDS pdxB NC_007606.1 2317402 2318538 R Code: HE; COG: COG0111; erythronate-4-phosphate dehydrogenase complement(2317402..2318538) Shigella dysenteriae Sd197 3797659 YP_404081.1 CDS flk NC_007606.1 2318637 2319632 D in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2318637..2319632 Shigella dysenteriae Sd197 3797660 YP_404082.1 CDS SDY_2521 NC_007606.1 2319629 2320081 R hypothetical protein complement(2319629..2320081) Shigella dysenteriae Sd197 3797661 YP_404083.1 CDS fabB NC_007606.1 2320477 2321697 R ''FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP''; 3-oxoacyl-ACP synthase complement(2320477..2321697) Shigella dysenteriae Sd197 3797662 YP_404084.2 CDS mnmC NC_007606.1 2321856 2323862 D catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2321856..2323862 Shigella dysenteriae Sd197 3797663 YP_404085.1 CDS SDY_2524 NC_007606.1 2323983 2324261 R hypothetical protein complement(2323983..2324261) Shigella dysenteriae Sd197 3797664 YP_404086.1 CDS SDY_2525 NC_007606.1 2324295 2324843 R Code: S; COG: COG3101; transporting ATPase complement(2324295..2324843) Shigella dysenteriae Sd197 3797665 YP_404087.1 CDS mepA NC_007606.1 2325652 2326476 R D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase complement(2325652..2326476) Shigella dysenteriae Sd197 3797667 YP_404088.1 CDS aroC NC_007606.1 2326480 2327565 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(2326480..2327565) Shigella dysenteriae Sd197 3797668 YP_404089.2 CDS SDY_2530 NC_007606.1 2327600 2328532 R involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(2327600..2328532) Shigella dysenteriae Sd197 3797631 YP_404090.1 CDS SDY_2529 NC_007606.1 2328698 2329249 D Code: S; COG: COG2840; hypothetical protein 2328698..2329249 Shigella dysenteriae Sd197 3797669 YP_404092.1 CDS SDY_2532 NC_007606.1 2330258 2330797 R Code: NU; COG: COG3539; fimbrial-like protein complement(2330258..2330797) Shigella dysenteriae Sd197 3797633 YP_404093.1 CDS SDY_2533 NC_007606.1 2330794 2331282 R Code: NU; COG: COG3539; hypothetical protein complement(2330794..2331282) Shigella dysenteriae Sd197 3797634 YP_404094.1 CDS SDY_2534 NC_007606.1 2331279 2331785 R Code: NU; COG: COG3539; fimbrial protein complement(2331279..2331785) Shigella dysenteriae Sd197 3797635 YP_404095.1 CDS yfcS NC_007606.1 2331801 2332550 R Code: NU; COG: COG3121; chaperone complement(2331801..2332550) Shigella dysenteriae Sd197 3797636 YP_404099.1 CDS insB NC_007606.1 2336242 2336619 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2336242..2336619) Shigella dysenteriae Sd197 3797640 YP_404100.1 CDS insA NC_007606.1 2336664 2336939 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2336664..2336939) Shigella dysenteriae Sd197 3797641 YP_404101.1 CDS SDY_2541 NC_007606.1 2337298 2337783 R Code: T; COG: COG2062; phosphohistidine phosphatase complement(2337298..2337783) Shigella dysenteriae Sd197 3797642 YP_404102.1 CDS fadJ NC_007606.1 2337986 2340130 R multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha complement(2337986..2340130) Shigella dysenteriae Sd197 3797643 YP_404103.1 CDS fadI NC_007606.1 2340130 2341440 R FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase complement(2340130..2341440) Shigella dysenteriae Sd197 3797644 YP_404104.1 CDS SDY_2544 NC_007606.1 2341621 2341929 R Code: S; COG: COG3691; hypothetical protein complement(2341621..2341929) Shigella dysenteriae Sd197 3797645 YP_404105.1 CDS fadL NC_007606.1 2342270 2343616 D transport of long-chain fatty acids; sensitivity to phage T2; Code: I; COG: COG2067; long-chain fatty acid outer membrane transporter 2342270..2343616 Shigella dysenteriae Sd197 3797646 YP_009000787.1 CDS SDY_4712 NC_007606.1 2343883 2344155 D insertion element iso-IS1N protein InsA 2343883..2344155 Shigella dysenteriae Sd197 18263101 YP_404108.1 CDS insB NC_007606.1 2344556 2344933 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2344556..2344933) Shigella dysenteriae Sd197 3797649 YP_404109.1 CDS insA NC_007606.1 2344978 2345253 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2344978..2345253) Shigella dysenteriae Sd197 3797650 YP_404110.1 CDS vacJ NC_007606.1 2346527 2347282 R Code: M; COG: COG2853; lipoprotein complement(2346527..2347282) Shigella dysenteriae Sd197 3795635 YP_404111.1 CDS yfdC NC_007606.1 2347575 2348507 D Code: P; COG: COG2116; transporter 2347575..2348507 Shigella dysenteriae Sd197 3795636 YP_404112.1 CDS insB NC_007606.1 2349124 2349501 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2349124..2349501) Shigella dysenteriae Sd197 3795638 YP_404113.1 CDS insA NC_007606.1 2349546 2349821 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2349546..2349821) Shigella dysenteriae Sd197 3795639 YP_404114.1 CDS SDY_2555 NC_007606.1 2350792 2351187 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2350792..2351187 Shigella dysenteriae Sd197 3795640 YP_404115.1 CDS SDY_2558 NC_007606.1 2353098 2354531 D Code: G; COG: COG1621; sucrose hydrolase 2353098..2354531 Shigella dysenteriae Sd197 3795643 YP_404116.1 CDS SDY_2559 NC_007606.1 2354539 2355534 R Code: K; COG: COG1609; sucrose operon repressor complement(2354539..2355534) Shigella dysenteriae Sd197 3795644 YP_404117.1 CDS SDY_2560 NC_007606.1 2355777 2355995 D D-serine permease 2355777..2355995 Shigella dysenteriae Sd197 3795645 YP_404118.1 CDS dsdA NC_007606.1 2356013 2357341 D deaminase; catalyzes the formation of pyruvate from serine; D-serine dehydratase 2356013..2357341 Shigella dysenteriae Sd197 3795646 YP_404119.1 CDS emrY NC_007606.1 2357449 2358987 R Code: GEPR; COG: COG0477; multidrug resistance protein Y complement(2357449..2358987) Shigella dysenteriae Sd197 3795647 YP_404120.1 CDS emrK NC_007606.1 2358987 2360150 R Code: V; COG: COG1566; multidrug resistance protein K complement(2358987..2360150) Shigella dysenteriae Sd197 3795648 YP_009000788.1 CDS SDY_4713 NC_007606.1 2360937 2361209 D insertion element iso-IS1N protein InsA 2360937..2361209 Shigella dysenteriae Sd197 18263102 YP_404121.1 CDS SDY_2565 NC_007606.1 2361236 2361631 D Code: L; COG: COG1662; insertion element IS1 protein InsB 2361236..2361631 Shigella dysenteriae Sd197 3795650 YP_404122.1 CDS SDY_2567 NC_007606.1 2363192 2363587 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(2363192..2363587) Shigella dysenteriae Sd197 3795652 YP_009000789.1 CDS SDY_4714 NC_007606.1 2363614 2363886 R insertion element iso-IS1N protein InsA complement(2363614..2363886) Shigella dysenteriae Sd197 18263103 YP_404123.1 CDS insA NC_007606.1 2364711 2364986 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2364711..2364986) Shigella dysenteriae Sd197 3797086 YP_404124.1 CDS yfdE NC_007606.1 2365253 2366437 R Code: C; COG: COG1804; hypothetical protein complement(2365253..2366437) Shigella dysenteriae Sd197 3797087 YP_404125.1 CDS SDY_2570 NC_007606.1 2366472 2367416 R member of the AEC family of auxin efflux transporters; unknown function; transporter YfdV complement(2366472..2367416) Shigella dysenteriae Sd197 3797088 YP_404126.1 CDS SDY_2571 NC_007606.1 2367486 2369180 R catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase complement(2367486..2369180) Shigella dysenteriae Sd197 3797089 YP_404127.1 CDS SDY_2572 NC_007606.1 2369234 2370484 R catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase complement(2369234..2370484) Shigella dysenteriae Sd197 3797090 YP_404128.1 CDS SDY_2573 NC_007606.1 2370996 2371628 R hypothetical protein complement(2370996..2371628) Shigella dysenteriae Sd197 3797091 YP_404129.1 CDS SDY_2574 NC_007606.1 2371924 2372199 D hypothetical protein 2371924..2372199 Shigella dysenteriae Sd197 3797092 YP_404130.1 CDS SDY_2575 NC_007606.1 2372276 2372518 R hypothetical protein complement(2372276..2372518) Shigella dysenteriae Sd197 3797093 YP_404131.2 CDS ddg NC_007606.1 2372871 2373791 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2372871..2373791 Shigella dysenteriae Sd197 3797094 YP_404132.1 CDS SDY_2577 NC_007606.1 2374284 2375522 R Code: E; COG: COG0436; aminotransferase complement(2374284..2375522) Shigella dysenteriae Sd197 3797095 YP_404133.1 CDS SDY_2578 NC_007606.1 2375602 2375847 R hypothetical protein complement(2375602..2375847) Shigella dysenteriae Sd197 3797096 YP_404134.1 CDS SDY_2579 NC_007606.1 2375899 2377596 D Code: T; COG: COG3275; sensor protein 2375899..2377596 Shigella dysenteriae Sd197 3797097 YP_404135.1 CDS SDY_2583 NC_007606.1 2381611 2382648 R metalloprotein; exoaminopeptidase complement(2381611..2382648) Shigella dysenteriae Sd197 3797101 YP_404136.1 CDS SDY_2584 NC_007606.1 2382648 2383562 R Code: E; COG: COG0006; peptidase complement(2382648..2383562) Shigella dysenteriae Sd197 3797102 YP_404137.1 CDS SDY_2585 NC_007606.1 2383577 2384824 R Code: G; COG: COG1299; transport protein complement(2383577..2384824) Shigella dysenteriae Sd197 3797103 YP_404138.1 CDS SDY_2586 NC_007606.1 2384846 2385172 R Code: G; COG: COG1445; PTS system transporter subunit IIB complement(2384846..2385172) Shigella dysenteriae Sd197 3797104 YP_404139.1 CDS glk NC_007606.1 2385391 2386356 R catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase complement(2385391..2386356) Shigella dysenteriae Sd197 3797105 YP_404140.1 CDS SDY_2588 NC_007606.1 2386735 2387973 R Code: P; COG: COG1914; manganese transport protein MntH complement(2386735..2387973) Shigella dysenteriae Sd197 3798544 YP_404141.1 CDS SDY_2589 NC_007606.1 2388271 2388681 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 2388271..2388681 Shigella dysenteriae Sd197 3798545 YP_404143.1 CDS SDY_2591 NC_007606.1 2389430 2389645 R insertion element iso-IS1n protein InsB complement(2389430..2389645) Shigella dysenteriae Sd197 3798547 YP_009000790.1 CDS SDY_4715 NC_007606.1 2389852 2390124 R insertion element iso-IS1N protein InsA complement(2389852..2390124) Shigella dysenteriae Sd197 18263104 YP_404145.1 CDS nupC NC_007606.1 2390420 2391622 D Code: F; COG: COG1972; nucleosides transporter 2390420..2391622 Shigella dysenteriae Sd197 3798549 YP_404146.1 CDS yfeC NC_007606.1 2394271 2394630 D hypothetical protein 2394271..2394630 Shigella dysenteriae Sd197 3798552 YP_404147.1 CDS yfeD NC_007606.1 2394632 2395024 D hypothetical protein 2394632..2395024 Shigella dysenteriae Sd197 3798553 YP_404148.1 CDS SDY_2598 NC_007606.1 2395064 2396272 R Code: L; COG: COG0675; virulence protein complement(2395064..2396272) Shigella dysenteriae Sd197 3798554 YP_404149.1 CDS SDY_2599 NC_007606.1 2396280 2396822 D Code: L; COG: COG1943; transposase TnA 2396280..2396822 Shigella dysenteriae Sd197 3798555 YP_404150.1 CDS gltX NC_007606.1 2396823 2398238 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(2396823..2398238) Shigella dysenteriae Sd197 3798556 YP_404151.1 CDS flxA NC_007606.1 2399046 2399387 D hypothetical protein 2399046..2399387 Shigella dysenteriae Sd197 3799788 YP_404152.1 CDS yfeH NC_007606.1 2400394 2401392 D Code: R; COG: COG0385; cytochrome oxidase 2400394..2401392 Shigella dysenteriae Sd197 3799790 YP_404153.1 CDS SDY_2607 NC_007606.1 2401389 2401607 R Code: S; COG: COG3530; hypothetical protein complement(2401389..2401607) Shigella dysenteriae Sd197 3799791 YP_404154.1 CDS ligA NC_007606.1 2401609 2403624 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(2401609..2403624) Shigella dysenteriae Sd197 3799792 YP_404155.1 CDS zipA NC_007606.1 2403695 2404693 R interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA complement(2403695..2404693) Shigella dysenteriae Sd197 3799793 YP_404156.1 CDS cysZ NC_007606.1 2404923 2405684 D role in sulfur assimilation; sulfate transport protein CysZ 2404923..2405684 Shigella dysenteriae Sd197 3799794 YP_404157.1 CDS cysK NC_007606.1 2405869 2406840 D O-acetylserine sulfhydrolase A; CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2405869..2406840 Shigella dysenteriae Sd197 3799795 YP_404158.1 CDS ptsH NC_007606.1 2407224 2407481 D Code: G; COG: COG1925; phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr) 2407224..2407481 Shigella dysenteriae Sd197 3799796 YP_404159.1 CDS ptsI NC_007606.1 2407526 2409253 D ''Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system''; phosphoenolpyruvate-protein phosphotransferase 2407526..2409253 Shigella dysenteriae Sd197 3799797 YP_404160.1 CDS crr NC_007606.1 2409294 2409803 D functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit IIA 2409294..2409803 Shigella dysenteriae Sd197 3799798 YP_404161.1 CDS pdxK NC_007606.1 2409846 2410697 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase complement(2409846..2410697) Shigella dysenteriae Sd197 3799799 YP_404162.1 CDS yfeK NC_007606.1 2410802 2411170 D hypothetical protein 2410802..2411170 Shigella dysenteriae Sd197 3799800 YP_404163.1 CDS cysM NC_007606.1 2411173 2412084 R O-acetylserine sulfhydrolase B; catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B complement(2411173..2412084) Shigella dysenteriae Sd197 3799801 YP_404164.1 CDS cysA NC_007606.1 2412218 2413315 R chromate resistance; Code: P; COG: COG1118; sulfate/thiosulfate ABC transporter ATP-binding protein complement(2412218..2413315) Shigella dysenteriae Sd197 3799802 YP_404165.1 CDS cysW NC_007606.1 2413305 2414180 R Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate ABC transporter substrate-binding protein complement(2413305..2414180) Shigella dysenteriae Sd197 3799803 YP_404166.1 CDS cysU NC_007606.1 2414180 2415013 R Code: O; COG: COG0555; sulfate/thiosulfate transporter permease complement(2414180..2415013) Shigella dysenteriae Sd197 3799804 YP_404167.1 CDS cysP NC_007606.1 2415013 2416029 R Code: P; COG: COG4150; thiosulfate transporter extracellular solute-binding protein complement(2415013..2416029) Shigella dysenteriae Sd197 3799805 YP_404168.2 CDS ucpA NC_007606.1 2416333 2417124 R Code: IQR; COG: COG1028; short chain dehydrogenase complement(2416333..2417124) Shigella dysenteriae Sd197 3797949 YP_404169.1 CDS yfeT NC_007606.1 2417253 2418110 R Code: K; COG: COG1737; hypothetical protein complement(2417253..2418110) Shigella dysenteriae Sd197 3797950 YP_404170.1 CDS murQ NC_007606.1 2418274 2419170 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 2418274..2419170 Shigella dysenteriae Sd197 3797951 YP_404171.1 CDS murP NC_007606.1 2419174 2420598 D belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; N-acetylmuramic acid phosphotransfer permease 2419174..2420598 Shigella dysenteriae Sd197 3797952 YP_009000791.1 CDS SDY_4716 NC_007606.1 2421945 2422217 R insertion element iso-IS1N protein InsA complement(2421945..2422217) Shigella dysenteriae Sd197 18263105 YP_404174.1 CDS SDY_2629 NC_007606.1 2422738 2423664 R Code: P; COG: COG2837; hypothetical protein complement(2422738..2423664) Shigella dysenteriae Sd197 3797956 YP_404175.1 CDS SDY_2630 NC_007606.1 2423733 2424308 R hypothetical protein complement(2423733..2424308) Shigella dysenteriae Sd197 3797957 YP_404176.1 CDS SDY_2631 NC_007606.1 2424369 2424824 R hypothetical protein complement(2424369..2424824) Shigella dysenteriae Sd197 3797958 YP_404177.2 CDS SDY_2632 NC_007606.1 2424805 2425230 R Code: R; COG: COG0456; acetyltransferase complement(2424805..2425230) Shigella dysenteriae Sd197 3797959 YP_404178.1 CDS amiA NC_007606.1 2425444 2426313 D Code: M; COG: COG0860; N-acetylmuramoyl-L-alanine amidase 2425444..2426313 Shigella dysenteriae Sd197 3797960 YP_404179.1 CDS hemF NC_007606.1 2426317 2427216 D catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2426317..2427216 Shigella dysenteriae Sd197 3797961 YP_404180.1 CDS yfeG NC_007606.1 2427222 2428274 R activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR complement(2427222..2428274) Shigella dysenteriae Sd197 3797962 YP_404181.1 CDS SDY_2636 NC_007606.1 2428320 2428826 R Code: QC; COG: COG4577; hypothetical protein complement(2428320..2428826) Shigella dysenteriae Sd197 3797963 YP_404182.1 CDS SDY_2637 NC_007606.1 2428833 2429492 R Code: E; COG: COG4816; hypothetical protein complement(2428833..2429492) Shigella dysenteriae Sd197 3797964 YP_404183.1 CDS eutC NC_007606.1 2429502 2430389 R catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit complement(2429502..2430389) Shigella dysenteriae Sd197 3797965 YP_009000792.1 CDS SDY_4717 NC_007606.1 2431210 2431482 D insertion element iso-IS1N protein InsA 2431210..2431482 Shigella dysenteriae Sd197 18263106 YP_009000793.1 CDS SDY_4718 NC_007606.1 2432675 2432947 R insertion element iso-IS1N protein InsA complement(2432675..2432947) Shigella dysenteriae Sd197 18263107 YP_404188.1 CDS SDY_2644 NC_007606.1 2432843 2433073 D hypothetical protein 2432843..2433073 Shigella dysenteriae Sd197 3797297 YP_404189.1 CDS SDY_2645 NC_007606.1 2433384 2435663 R NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme complement(2433384..2435663) Shigella dysenteriae Sd197 3797298 YP_404190.1 CDS SDY_2648 NC_007606.1 2437903 2438298 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(2437903..2438298) Shigella dysenteriae Sd197 3797301 YP_009000794.1 CDS SDY_4719 NC_007606.1 2438325 2438597 R insertion element iso-IS1N protein InsA complement(2438325..2438597) Shigella dysenteriae Sd197 18263108 YP_404191.1 CDS SDY_2649 NC_007606.1 2439779 2440846 R hypothetical protein complement(2439779..2440846) Shigella dysenteriae Sd197 3797302 YP_404192.1 CDS yffH NC_007606.1 2440972 2441547 R Code: LR; COG: COG0494; hypothetical protein complement(2440972..2441547) Shigella dysenteriae Sd197 3797303 YP_404193.1 CDS yffG NC_007606.1 2441615 2443594 R ''unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)''; oxidoreductase Fe-S binding subunit complement(2441615..2443594) Shigella dysenteriae Sd197 3797304 YP_404194.1 CDS SDY_2652 NC_007606.1 2443626 2444021 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2443626..2444021) Shigella dysenteriae Sd197 3797305 YP_009000795.1 CDS SDY_4720 NC_007606.1 2444048 2444320 R insertion element iso-IS1N protein InsA complement(2444048..2444320) Shigella dysenteriae Sd197 18263109 YP_404195.1 CDS narQ NC_007606.1 2444574 2446274 D protein histidine kinase (acts on NarP and narL); Code: T; COG: COG3850; nitrate/nitrite sensor protein NarQ 2444574..2446274 Shigella dysenteriae Sd197 3797306 YP_404196.1 CDS acrD NC_007606.1 2446438 2449551 D sensitivity to acriflavine, integral membrane protein, possible efflux pump; Code: V; COG: COG0841; aminoglycoside/multidrug efflux system 2446438..2449551 Shigella dysenteriae Sd197 3797307 YP_404197.1 CDS yffB NC_007606.1 2450090 2450446 D Code: P; COG: COG1393; hypothetical protein 2450090..2450446 Shigella dysenteriae Sd197 3797308 YP_404198.1 CDS dapE NC_007606.1 2450450 2451577 D ''dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.''; succinyl-diaminopimelate desuccinylase 2450450..2451577 Shigella dysenteriae Sd197 3797309 YP_404199.2 CDS SDY_2657 NC_007606.1 2451605 2451805 D hypothetical protein 2451605..2451805 Shigella dysenteriae Sd197 3797310 YP_404202.1 CDS SDY_2660 NC_007606.1 2452667 2453062 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(2452667..2453062) Shigella dysenteriae Sd197 3797313 YP_009000796.1 CDS SDY_4721 NC_007606.1 2453089 2453361 R insertion element iso-IS1N protein InsA complement(2453089..2453361) Shigella dysenteriae Sd197 18263110 YP_404203.1 CDS ypfI NC_007606.1 2453433 2455448 R Code: R; COG: COG1444; hypothetical protein complement(2453433..2455448) Shigella dysenteriae Sd197 3798579 YP_404206.1 CDS purC NC_007606.1 2456494 2457207 R SAICAR synthetase; catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(2456494..2457207) Shigella dysenteriae Sd197 3798582 YP_404208.1 CDS nlpB NC_007606.1 2457420 2458457 R Code: M; COG: COG3317; lipoprotein complement(2457420..2458457) Shigella dysenteriae Sd197 3798584 YP_404209.1 CDS dapA NC_007606.1 2458471 2459349 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(2458471..2459349) Shigella dysenteriae Sd197 3798585 YP_404210.2 CDS gcvR NC_007606.1 2459495 2460067 D negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2459495..2460067 Shigella dysenteriae Sd197 3798586 YP_404211.1 CDS bcp NC_007606.1 2460067 2460537 D bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2460067..2460537 Shigella dysenteriae Sd197 3798587 YP_404212.1 CDS hyfA NC_007606.1 2460751 2461407 D Code: C; COG: COG1142; hydrogenase 4 Fe-S subunit 2460751..2461407 Shigella dysenteriae Sd197 3798588 YP_404213.1 CDS hyfB NC_007606.1 2461407 2463425 D Code: CP; COG: COG0651; hydrogenase 4 subunit B 2461407..2463425 Shigella dysenteriae Sd197 3798589 YP_404214.1 CDS hyfC NC_007606.1 2463415 2464383 D Code: C; COG: COG0650; hydrogenase 4 membrane subunit 2463415..2464383 Shigella dysenteriae Sd197 3798590 YP_404215.1 CDS hyfE NC_007606.1 2465851 2466501 D interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2465851..2466501 Shigella dysenteriae Sd197 3798592 YP_404216.1 CDS hyfF NC_007606.1 2466506 2468086 D Code: CP; COG: COG0651; hydrogenase 4 subunit F 2466506..2468086 Shigella dysenteriae Sd197 3798593 YP_404217.1 CDS hyfG NC_007606.1 2468076 2469791 D Code: C; COG: COG3261; hydrogenase 4 subunit G 2468076..2469791 Shigella dysenteriae Sd197 3798594 YP_404218.1 CDS hyfI NC_007606.1 2470343 2471101 D Code: C; COG: COG3260; hydrogenase 4 Fe-S subunit 2470343..2471101 Shigella dysenteriae Sd197 3798596 YP_404219.1 CDS SDY_2679 NC_007606.1 2471031 2471507 D protein processing element 2471031..2471507 Shigella dysenteriae Sd197 3798597 YP_404220.1 CDS focB NC_007606.1 2473571 2474419 D formate channel 2; inner membrane protein presumed to act as a formate transporter; member of the hyf operon; formate transporter 2473571..2474419 Shigella dysenteriae Sd197 3798099 YP_404221.1 CDS perM NC_007606.1 2474457 2475518 R Code: R; COG: COG0628; permease complement(2474457..2475518) Shigella dysenteriae Sd197 3798100 YP_404222.1 CDS SDY_2683 NC_007606.1 2475732 2477195 D Code: R; COG: COG4783; hypothetical protein 2475732..2477195 Shigella dysenteriae Sd197 3798101 YP_404223.1 CDS SDY_2684 NC_007606.1 2477216 2477575 D Code: P; COG: COG1393; oxidoreductase 2477216..2477575 Shigella dysenteriae Sd197 3798102 YP_404224.1 CDS SDY_2685 NC_007606.1 2477713 2478459 R ''controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP''; DNA replication initiation factor complement(2477713..2478459) Shigella dysenteriae Sd197 3798103 YP_404225.1 CDS uraA NC_007606.1 2478509 2479798 R Code: F; COG: COG2233; uracil transporter complement(2478509..2479798) Shigella dysenteriae Sd197 3798104 YP_404226.2 CDS upp NC_007606.1 2479884 2480510 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(2479884..2480510) Shigella dysenteriae Sd197 3798105 YP_404227.1 CDS purM NC_007606.1 2480836 2481873 D AIR synthetase; catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2480836..2481873 Shigella dysenteriae Sd197 3798106 YP_404228.1 CDS purN NC_007606.1 2481873 2482511 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2481873..2482511 Shigella dysenteriae Sd197 3798107 YP_404229.1 CDS ppk NC_007606.1 2482682 2484748 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2482682..2484748 Shigella dysenteriae Sd197 3798108 YP_404230.1 CDS ppx NC_007606.1 2484753 2486294 D Code: FP; COG: COG0248; exopolyphosphatase 2484753..2486294 Shigella dysenteriae Sd197 3798109 YP_404231.2 CDS SDY_2693 NC_007606.1 2488581 2488976 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2488581..2488976) Shigella dysenteriae Sd197 3798111 YP_009000797.1 CDS SDY_4722 NC_007606.1 2489003 2489275 R insertion element iso-IS1N protein InsA complement(2489003..2489275) Shigella dysenteriae Sd197 18263111 YP_404233.1 CDS SDY_2695 NC_007606.1 2489488 2489883 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(2489488..2489883) Shigella dysenteriae Sd197 3798113 YP_009000798.1 CDS SDY_4723 NC_007606.1 2489910 2490137 R insertion element iso-IS1N protein InsA complement(2489910..2490137) Shigella dysenteriae Sd197 18263112 YP_404234.1 CDS SDY_2696 NC_007606.1 2490459 2490650 D hypothetical protein 2490459..2490650 Shigella dysenteriae Sd197 3798114 YP_009000799.1 CDS SDY_4724 NC_007606.1 2491021 2491293 D insertion element iso-IS1N protein InsA 2491021..2491293 Shigella dysenteriae Sd197 18263113 YP_404236.1 CDS SDY_2698 NC_007606.1 2491320 2491715 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2491320..2491715 Shigella dysenteriae Sd197 3798116 YP_404237.1 CDS SDY_2699 NC_007606.1 2491735 2492265 D Code: M; COG: COG3133; outer membrane lipoprotein 2491735..2492265 Shigella dysenteriae Sd197 3798117 YP_404238.2 CDS SDY_2700 NC_007606.1 2492236 2493141 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(2492236..2493141) Shigella dysenteriae Sd197 3798802 YP_404239.1 CDS SDY_2701 NC_007606.1 2493099 2493464 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(2493099..2493464) Shigella dysenteriae Sd197 3798803 YP_404240.1 CDS SDY_2702 NC_007606.1 2493605 2494144 D hypothetical protein 2493605..2494144 Shigella dysenteriae Sd197 3798804 YP_404241.1 CDS guaA NC_007606.1 2494237 2495814 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(2494237..2495814) Shigella dysenteriae Sd197 3798805 YP_404242.1 CDS guaB NC_007606.1 2495883 2497349 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2495883..2497349) Shigella dysenteriae Sd197 3798806 YP_404243.1 CDS xseA NC_007606.1 2497511 2498881 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2497511..2498881 Shigella dysenteriae Sd197 3798807 YP_404244.1 CDS SDY_2706 NC_007606.1 2498878 2499114 R hypothetical protein complement(2498878..2499114) Shigella dysenteriae Sd197 3798808 YP_404245.2 CDS engA NC_007606.1 2499162 2500634 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(2499162..2500634) Shigella dysenteriae Sd197 3798809 YP_404246.1 CDS SDY_2708 NC_007606.1 2500752 2501930 R ''with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis''; outer membrane protein assembly complex subunit YfgL complement(2500752..2501930) Shigella dysenteriae Sd197 3798810 YP_404247.1 CDS SDY_2709 NC_007606.1 2501941 2502561 R Code: S; COG: COG2976; hypothetical protein complement(2501941..2502561) Shigella dysenteriae Sd197 3798811 YP_404248.1 CDS hisS NC_007606.1 2502579 2503853 R ''catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG''; histidyl-tRNA synthetase complement(2502579..2503853) Shigella dysenteriae Sd197 3798812 YP_404249.1 CDS ispG NC_007606.1 2503964 2505082 R ''catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis''; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(2503964..2505082) Shigella dysenteriae Sd197 3798813 YP_404250.1 CDS yfgA NC_007606.1 2505109 2506122 R Code: S; COG: COG1426; hypothetical protein complement(2505109..2506122) Shigella dysenteriae Sd197 3798814 YP_404251.1 CDS yfgB NC_007606.1 2506407 2507561 R Code: R; COG: COG0820; hypothetical protein complement(2506407..2507561) Shigella dysenteriae Sd197 3798815 YP_404252.1 CDS ndk NC_007606.1 2507711 2508142 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(2507711..2508142) Shigella dysenteriae Sd197 3798816 YP_404253.2 CDS sseA NC_007606.1 2515771 2516616 D catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2515771..2516616 Shigella dysenteriae Sd197 3798819 YP_404254.2 CDS sseB NC_007606.1 2517763 2518539 R enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB complement(2517763..2518539) Shigella dysenteriae Sd197 3798820 YP_404255.2 CDS pepB NC_007606.1 2518682 2519965 R catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase complement(2518682..2519965) Shigella dysenteriae Sd197 3798821 YP_404256.1 CDS yfhJ NC_007606.1 2520143 2520343 R Code: S; COG: COG2975; hypothetical protein complement(2520143..2520343) Shigella dysenteriae Sd197 3798253 YP_404257.1 CDS fdx NC_007606.1 2520355 2520690 R Code: C; COG: COG0633; [2FE-2S] ferredoxin, electron carrer protein complement(2520355..2520690) Shigella dysenteriae Sd197 3798254 YP_404258.1 CDS hscA NC_007606.1 2520692 2522542 R heat shock protein, chaperone, member of Hsp70 protein family; involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(2520692..2522542) Shigella dysenteriae Sd197 3798255 YP_404259.1 CDS hscB NC_007606.1 2522559 2523074 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(2522559..2523074) Shigella dysenteriae Sd197 3798256 YP_404260.1 CDS iscA NC_007606.1 2523170 2523493 R forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein complement(2523170..2523493) Shigella dysenteriae Sd197 3798257 YP_404261.1 CDS SDY_2725 NC_007606.1 2523510 2523896 R Code: C; COG: COG0822; scaffold protein complement(2523510..2523896) Shigella dysenteriae Sd197 3798258 YP_404262.1 CDS yfhO NC_007606.1 2523924 2525162 R catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase complement(2523924..2525162) Shigella dysenteriae Sd197 3798259 YP_404263.1 CDS SDY_2727 NC_007606.1 2525250 2525738 R regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR complement(2525250..2525738) Shigella dysenteriae Sd197 3798260 YP_404264.1 CDS SDY_2728 NC_007606.1 2526038 2526775 R Code: J; COG: COG0565; ATP synthase subunit beta complement(2526038..2526775) Shigella dysenteriae Sd197 3798261 YP_404265.1 CDS suhB NC_007606.1 2526894 2527697 D enhances synthesis of sigma32 in mutant; extragenic suppressor, may modulate RNAse III lethal action; Code: G; COG: COG0483; inositol monophosphatase 2526894..2527697 Shigella dysenteriae Sd197 3798262 YP_404266.1 CDS SDY_2730 NC_007606.1 2527815 2528696 D Code: R; COG: COG1073; hydrolase 2527815..2528696 Shigella dysenteriae Sd197 3798263 YP_404267.2 CDS csiE NC_007606.1 2528887 2530167 D Code: K; COG: COG3711; stationary phase inducible protein CsiE 2528887..2530167 Shigella dysenteriae Sd197 3798264 YP_404268.1 CDS hcaT NC_007606.1 2530159 2531298 R transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter complement(2530159..2531298) Shigella dysenteriae Sd197 3798265 YP_404269.1 CDS SDY_2734 NC_007606.1 2531458 2531748 R hypothetical protein complement(2531458..2531748) Shigella dysenteriae Sd197 3798267 YP_404270.1 CDS SDY_2735 NC_007606.1 2531970 2532365 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2531970..2532365 Shigella dysenteriae Sd197 3798268 YP_404273.1 CDS SDY_2739 NC_007606.1 2536016 2536411 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2536016..2536411) Shigella dysenteriae Sd197 3797611 YP_009000800.1 CDS SDY_4725 NC_007606.1 2536438 2536710 R insertion element iso-IS1N protein InsA complement(2536438..2536710) Shigella dysenteriae Sd197 18263114 YP_404274.1 CDS yphH NC_007606.1 2536864 2538063 D Code: KG; COG: COG1940; NAGC-like transcriptional regulator 2536864..2538063 Shigella dysenteriae Sd197 3797612 YP_404275.1 CDS glyA NC_007606.1 2538126 2539379 R ''catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate''; serine hydroxymethyltransferase complement(2538126..2539379) Shigella dysenteriae Sd197 3797613 YP_404276.1 CDS hmpA NC_007606.1 2539706 2540896 D flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2539706..2540896 Shigella dysenteriae Sd197 3797614 YP_404277.1 CDS glnB NC_007606.1 2540941 2541279 R ''indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA''; nitrogen regulatory protein P-II 1 complement(2540941..2541279) Shigella dysenteriae Sd197 3797615 YP_404278.1 CDS yfhA NC_007606.1 2541340 2542674 R Code: T; COG: COG2204; 2-component transcriptional regulator complement(2541340..2542674) Shigella dysenteriae Sd197 3797616 YP_404279.1 CDS yfhG NC_007606.1 2542664 2543377 R hypothetical protein complement(2542664..2543377) Shigella dysenteriae Sd197 3797617 YP_404280.1 CDS yfhK NC_007606.1 2543542 2545032 R Code: T; COG: COG0642; 2-component sensor protein complement(2543542..2545032) Shigella dysenteriae Sd197 3797618 YP_404281.1 CDS purL NC_007606.1 2545533 2549420 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(2545533..2549420) Shigella dysenteriae Sd197 3797619 YP_404282.1 CDS yfhD NC_007606.1 2549820 2551238 D ''YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function''; transglycosylase 2549820..2551238 Shigella dysenteriae Sd197 3797620 YP_404283.1 CDS yfhC NC_007606.1 2551235 2551771 R Code: FJ; COG: COG0590; tRNA-specific adenosine deaminase complement(2551235..2551771) Shigella dysenteriae Sd197 3797621 YP_404284.2 CDS yfhB NC_007606.1 2551796 2552431 R Code: E; COG: COG0560; hypothetical protein complement(2551796..2552431) Shigella dysenteriae Sd197 3797622 YP_404285.2 CDS yfhH NC_007606.1 2552640 2553488 D Code: K; COG: COG1737; DNA-binding transcriptional regulator 2552640..2553488 Shigella dysenteriae Sd197 3797623 YP_404286.1 CDS SDY_2752 NC_007606.1 2554379 2554819 R Code: L; COG: COG1961; DNA-invertase complement(2554379..2554819) Shigella dysenteriae Sd197 3797624 YP_404287.1 CDS ipaH_6 NC_007606.1 2555309 2557135 D Code: S; COG: COG4886; invasion plasmid antigen 2555309..2557135 Shigella dysenteriae Sd197 3797625 YP_404289.1 CDS SDY_2755 NC_007606.1 2558149 2558451 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(2558149..2558451) Shigella dysenteriae Sd197 3797627 YP_009000801.1 CDS SDY_4726 NC_007606.1 2561099 2561371 D insertion element iso-IS1N protein InsA 2561099..2561371 Shigella dysenteriae Sd197 18263115 YP_404295.1 CDS SDY_2761 NC_007606.1 2561398 2561793 D Code: L; COG: COG1662; insertion element IS1 protein InsB 2561398..2561793 Shigella dysenteriae Sd197 3795355 YP_404296.1 CDS yfiL NC_007606.1 2561768 2562136 R hypothetical protein complement(2561768..2562136) Shigella dysenteriae Sd197 3795356 YP_404297.1 CDS insA NC_007606.1 2562219 2562494 D Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 2562219..2562494 Shigella dysenteriae Sd197 3795357 YP_404299.1 CDS aroF NC_007606.1 2563123 2564193 D DAHP synthetase, tyrosine repressible; ''catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive''; phospho-2-dehydro-3-deoxyheptonate aldolase 2563123..2564193 Shigella dysenteriae Sd197 3795359 YP_404300.1 CDS tyrA NC_007606.1 2564204 2565325 D prephenate dehydrogenase; catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 2564204..2565325 Shigella dysenteriae Sd197 3795360 YP_404301.1 CDS pheA NC_007606.1 2565368 2566528 R prephenate dehydratase; catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase complement(2565368..2566528) Shigella dysenteriae Sd197 3795361 YP_404302.1 CDS yfiA NC_007606.1 2566779 2567120 R associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA complement(2566779..2567120) Shigella dysenteriae Sd197 3795362 YP_404304.1 CDS SDY_2770 NC_007606.1 2569222 2569524 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 2569222..2569524 Shigella dysenteriae Sd197 3795364 YP_404305.1 CDS SDY_2771 NC_007606.1 2569665 2570378 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 2569665..2570378 Shigella dysenteriae Sd197 3795365 YP_404306.1 CDS SDY_2772 NC_007606.1 2570452 2571057 D hypothetical protein 2570452..2571057 Shigella dysenteriae Sd197 3795366 YP_404307.1 CDS SDY_2773 NC_007606.1 2571250 2571927 D tail fiber protein 2571250..2571927 Shigella dysenteriae Sd197 3795367 YP_404308.1 CDS SDY_2774 NC_007606.1 2571971 2572381 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 2571971..2572381 Shigella dysenteriae Sd197 3795368 YP_404310.1 CDS SDY_2776 NC_007606.1 2573130 2573525 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(2573130..2573525) Shigella dysenteriae Sd197 3795370 YP_404311.1 CDS SDY_2777 NC_007606.1 2573720 2574028 D hypothetical protein 2573720..2574028 Shigella dysenteriae Sd197 3795371 YP_404314.1 CDS rplS NC_007606.1 2575807 2576154 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(2575807..2576154) Shigella dysenteriae Sd197 3795887 YP_404315.1 CDS trmD NC_007606.1 2576196 2576963 R tRNA (guanine-7-)-methyltransferase; methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(2576196..2576963) Shigella dysenteriae Sd197 3795888 YP_404316.2 CDS rimM NC_007606.1 2576994 2577542 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(2576994..2577542) Shigella dysenteriae Sd197 3795889 YP_404317.1 CDS rpsP NC_007606.1 2577561 2577809 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(2577561..2577809) Shigella dysenteriae Sd197 3795890 YP_404318.1 CDS ffh NC_007606.1 2577946 2579307 R binds to signal sequence, GTP and RNA; with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein complement(2577946..2579307) Shigella dysenteriae Sd197 3795891 YP_404319.1 CDS SDY_2785 NC_007606.1 2579399 2580265 D Code: R; COG: COG4137; hypothetical protein 2579399..2580265 Shigella dysenteriae Sd197 3795892 YP_404320.2 CDS yfjD NC_007606.1 2580376 2581572 D Code: P; COG: COG4536; hypothetical protein 2580376..2581572 Shigella dysenteriae Sd197 3795893 YP_404321.1 CDS grpE NC_007606.1 2581627 2582220 R phage lambda replication; host DNA synthesis; heat shock protein; protein repair; with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(2581627..2582220) Shigella dysenteriae Sd197 3795894 YP_404322.1 CDS ppnK NC_007606.1 2582343 2583221 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2582343..2583221 Shigella dysenteriae Sd197 3795895 YP_404323.1 CDS recN NC_007606.1 2583307 2584968 D Code: L; COG: COG0497; recombination and repair protein 2583307..2584968 Shigella dysenteriae Sd197 3795896 YP_404324.2 CDS smpA NC_007606.1 2585117 2585458 D Code: J; COG: COG2913; hypothetical protein 2585117..2585458 Shigella dysenteriae Sd197 3795897 YP_404325.2 CDS SDY_2791 NC_007606.1 2585520 2585810 R Code: S; COG: COG2914; hypothetical protein complement(2585520..2585810) Shigella dysenteriae Sd197 3795898 YP_404326.1 CDS SDY_2792 NC_007606.1 2585800 2586276 R Code: I; COG: COG2867; hypothetical protein complement(2585800..2586276) Shigella dysenteriae Sd197 3795899 YP_404327.1 CDS smpB NC_007606.1 2586408 2586890 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2586408..2586890 Shigella dysenteriae Sd197 3795900 YP_404328.1 CDS SDY_2794 NC_007606.1 2587628 2587840 R hypothetical protein complement(2587628..2587840) Shigella dysenteriae Sd197 3795901 YP_009000802.1 CDS SDY_4727 NC_007606.1 2590094 2590366 D insertion element iso-IS1N protein InsA 2590094..2590366 Shigella dysenteriae Sd197 18263116 YP_404331.1 CDS SDY_2797 NC_007606.1 2590393 2590788 D Code: L; COG: COG1662; insertion element IS1 protein InsB 2590393..2590788 Shigella dysenteriae Sd197 3795904 YP_404332.1 CDS SDY_2798 NC_007606.1 2590988 2591923 D Code: KL; COG: COG0553; hypothetical protein 2590988..2591923 Shigella dysenteriae Sd197 3795499 YP_404335.1 CDS yfhL NC_007606.1 2593728 2593988 D Code: C; COG: COG1145; hypothetical protein 2593728..2593988 Shigella dysenteriae Sd197 3795502 YP_404336.1 CDS SDY_2802 NC_007606.1 2594468 2594863 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(2594468..2594863) Shigella dysenteriae Sd197 3795503 YP_009000803.1 CDS SDY_4728 NC_007606.1 2594890 2595162 R insertion element iso-IS1N protein InsA complement(2594890..2595162) Shigella dysenteriae Sd197 18263117 YP_404338.1 CDS acpS NC_007606.1 2595458 2595838 R ''Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids''; 4'-phosphopantetheinyl transferase complement(2595458..2595838) Shigella dysenteriae Sd197 3795505 YP_404339.1 CDS pdxJ NC_007606.1 2595838 2596569 R involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase complement(2595838..2596569) Shigella dysenteriae Sd197 3795506 YP_404340.1 CDS recO NC_007606.1 2596581 2597309 R protein interacts with RecR and possibly RecF proteins; involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(2596581..2597309) Shigella dysenteriae Sd197 3795507 YP_404341.1 CDS era NC_007606.1 2597321 2598226 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(2597321..2598226) Shigella dysenteriae Sd197 3795508 YP_404342.1 CDS rnc NC_007606.1 2598223 2598903 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(2598223..2598903) Shigella dysenteriae Sd197 3795509 YP_404343.1 CDS lepB NC_007606.1 2599176 2600150 R catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I complement(2599176..2600150) Shigella dysenteriae Sd197 3795510 YP_404344.1 CDS lepA NC_007606.1 2600166 2601965 R may be inner membrane protein; binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(2600166..2601965) Shigella dysenteriae Sd197 3795511 YP_404345.1 CDS rseC NC_007606.1 2602163 2602642 R involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC complement(2602163..2602642) Shigella dysenteriae Sd197 3795512 YP_404346.1 CDS rseB NC_007606.1 2602639 2603595 R periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE complement(2602639..2603595) Shigella dysenteriae Sd197 3795513 YP_404347.1 CDS rseA NC_007606.1 2603595 2604245 R Code: T; COG: COG3073; anti-RNA polymerase sigma factor SigE complement(2603595..2604245) Shigella dysenteriae Sd197 3795514 YP_404348.1 CDS rpoE NC_007606.1 2604278 2604853 R sigma-E factor; heat shock and oxidative stress; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(2604278..2604853) Shigella dysenteriae Sd197 3795515 YP_404349.1 CDS nadB NC_007606.1 2605261 2606883 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2605261..2606883 Shigella dysenteriae Sd197 3795516 YP_404350.1 CDS yfiC NC_007606.1 2606868 2607725 R Code: R; COG: COG4123; O-methyltransferase complement(2606868..2607725) Shigella dysenteriae Sd197 3795517 YP_404351.1 CDS srmB NC_007606.1 2607737 2609071 D facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2607737..2609071 Shigella dysenteriae Sd197 3795408 YP_404352.1 CDS yfiE NC_007606.1 2609104 2610030 R Code: K; COG: COG0583; LysR family transcriptional regulator complement(2609104..2610030) Shigella dysenteriae Sd197 3795409 YP_404353.1 CDS SDY_2819 NC_007606.1 2610310 2610612 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 2610310..2610612 Shigella dysenteriae Sd197 3795410 YP_404355.1 CDS yfiK NC_007606.1 2611478 2611867 D Code: E; COG: COG1280; hypothetical protein 2611478..2611867 Shigella dysenteriae Sd197 3795412 YP_404356.1 CDS yfiD NC_007606.1 2611923 2612306 R stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA complement(2611923..2612306) Shigella dysenteriae Sd197 3795413 YP_404357.1 CDS ung NC_007606.1 2612610 2613299 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2612610..2613299 Shigella dysenteriae Sd197 3795414 YP_404358.1 CDS yfiF NC_007606.1 2613347 2614384 R Code: J; COG: COG0566; methyltransferase complement(2613347..2614384) Shigella dysenteriae Sd197 3795415 YP_404359.1 CDS trxC NC_007606.1 2614591 2615010 D Code: OC; COG: COG0526; thioredoxin 2614591..2615010 Shigella dysenteriae Sd197 3795416 YP_404360.1 CDS yfiP NC_007606.1 2615055 2615777 D Code: S; COG: COG3148; hypothetical protein 2615055..2615777 Shigella dysenteriae Sd197 3795417 YP_404361.1 CDS yfiQ NC_007606.1 2615809 2618469 D Code: C; COG: COG1042; hypothetical protein 2615809..2618469 Shigella dysenteriae Sd197 3795418 YP_404362.1 CDS pssA NC_007606.1 2618580 2619938 D phospholipid synthesis; catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2618580..2619938 Shigella dysenteriae Sd197 3795419 YP_404363.1 CDS yfiM NC_007606.1 2620011 2620307 D Code: R; COG: COG5544; hypothetical protein 2620011..2620307 Shigella dysenteriae Sd197 3795420 YP_404364.1 CDS kgtP NC_007606.1 2620304 2621602 R Code: GEPR; COG: COG0477; alpha-ketoglutarate transporter complement(2620304..2621602) Shigella dysenteriae Sd197 3795421 YP_404365.1 CDS clpB NC_007606.1 2627369 2629942 R Code: O; COG: COG0542; protein disaggregation chaperone complement(2627369..2629942) Shigella dysenteriae Sd197 3796209 YP_404366.1 CDS yfiH NC_007606.1 2630072 2630803 R Code: S; COG: COG1496; hypothetical protein complement(2630072..2630803) Shigella dysenteriae Sd197 3796210 YP_404367.1 CDS rluD NC_007606.1 2630800 2631780 R ''responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA''; 23S rRNA pseudouridine synthase D complement(2630800..2631780) Shigella dysenteriae Sd197 3796211 YP_404368.1 CDS SDY_2838 NC_007606.1 2631915 2632652 D ''with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline''; outer membrane protein assembly complex subunit YfiO 2631915..2632652 Shigella dysenteriae Sd197 3796212 YP_404369.1 CDS SDY_2839 NC_007606.1 2632703 2634049 R Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG complement(2632703..2634049) Shigella dysenteriae Sd197 3796213 YP_404371.1 CDS SDY_2841 NC_007606.1 2634493 2634813 D Code: L; COG: COG3436; insertion sequence element ISSfl4 ORF2 2634493..2634813 Shigella dysenteriae Sd197 3796215 YP_404372.1 CDS SDY_2842 NC_007606.1 2635051 2635881 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(2635051..2635881) Shigella dysenteriae Sd197 3796216 YP_404373.1 CDS SDY_2843 NC_007606.1 2636022 2636324 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(2636022..2636324) Shigella dysenteriae Sd197 3796217 YP_009000804.1 CDS SDY_2844a NC_007606.1 2636520 2636681 D hypothetical protein 2636520..2636681 Shigella dysenteriae Sd197 18263118 YP_404375.1 CDS SDY_2845 NC_007606.1 2637298 2637600 R Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN complement(2637298..2637600) Shigella dysenteriae Sd197 3796219 YP_404376.1 CDS SDY_2846 NC_007606.1 2637670 2638437 R Code: L; COG: COG2801; hypothetical protein complement(2637670..2638437) Shigella dysenteriae Sd197 3796220 YP_404377.1 CDS SDY_2847 NC_007606.1 2638542 2638937 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2638542..2638937) Shigella dysenteriae Sd197 3796221 YP_009000805.1 CDS SDY_4729 NC_007606.1 2638964 2639236 R insertion element iso-IS1N protein InsA complement(2638964..2639236) Shigella dysenteriae Sd197 18263119 YP_404378.1 CDS SDY_2848 NC_007606.1 2639272 2639802 R hypothetical protein complement(2639272..2639802) Shigella dysenteriae Sd197 3796222 YP_404379.1 CDS insB NC_007606.1 2639839 2640216 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2639839..2640216) Shigella dysenteriae Sd197 3796223 YP_404380.1 CDS insA NC_007606.1 2640261 2640536 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2640261..2640536) Shigella dysenteriae Sd197 3796224 YP_404381.1 CDS gabP NC_007606.1 2642377 2643777 D Code: E; COG: COG1113; gamma-aminobutyrate transporter 2642377..2643777 Shigella dysenteriae Sd197 3796131 YP_404382.2 CDS ygaE NC_007606.1 2643798 2644460 D regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2643798..2644460 Shigella dysenteriae Sd197 3796132 YP_404383.1 CDS ygaU NC_007606.1 2644461 2644910 R Code: S; COG: COG1652; LysM domain/BON superfamily protein complement(2644461..2644910) Shigella dysenteriae Sd197 3796133 YP_404384.1 CDS SDY_2856 NC_007606.1 2644994 2645152 R Code: S; COG: COG0401; hypothetical protein complement(2644994..2645152) Shigella dysenteriae Sd197 3796134 YP_404385.1 CDS SDY_2857 NC_007606.1 2645335 2645634 D Code: K; COG: COG0640; hypothetical protein 2645335..2645634 Shigella dysenteriae Sd197 3796135 YP_404386.1 CDS ygaP NC_007606.1 2645644 2646162 D Code: P; COG: COG0607; hypothetical protein 2645644..2646162 Shigella dysenteriae Sd197 3796136 YP_404387.1 CDS stpA NC_007606.1 2646215 2646619 R H-NS-like protein; chaperone activity; possibly involved in RNA splicing; Code: R; COG: COG2916; DNA binding protein complement(2646215..2646619) Shigella dysenteriae Sd197 3796137 YP_404388.1 CDS SDY_2860 NC_007606.1 2647288 2647737 D hypothetical protein 2647288..2647737 Shigella dysenteriae Sd197 3796138 YP_009000806.1 CDS SDY_4730 NC_007606.1 2647858 2648130 D insertion element iso-IS1N protein InsA 2647858..2648130 Shigella dysenteriae Sd197 18263120 YP_404390.1 CDS ygaC NC_007606.1 2648528 2648893 R hypothetical protein complement(2648528..2648893) Shigella dysenteriae Sd197 3796140 YP_404391.1 CDS ygaM NC_007606.1 2649033 2649374 D Code: S; COG: COG4575; hypothetical protein 2649033..2649374 Shigella dysenteriae Sd197 3796141 YP_404392.1 CDS SDY_2864 NC_007606.1 2649524 2650858 R Code: KE; COG: COG1167; transcriptional regulator complement(2649524..2650858) Shigella dysenteriae Sd197 3796142 YP_404393.1 CDS SDY_2865 NC_007606.1 2650946 2651377 D Code: S; COG: COG2128; hypothetical protein 2650946..2651377 Shigella dysenteriae Sd197 3796143 YP_404394.1 CDS nrdH NC_007606.1 2651587 2651832 D hydrogen donor; Code: O; COG: COG0695; glutaredoxin-like protein 2651587..2651832 Shigella dysenteriae Sd197 3796144 YP_404395.1 CDS nrdI NC_007606.1 2651829 2652239 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2651829..2652239 Shigella dysenteriae Sd197 3796145 YP_404397.1 CDS nrdF NC_007606.1 2654366 2655334 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2654366..2655334 Shigella dysenteriae Sd197 3796147 YP_404398.1 CDS insB NC_007606.1 2655328 2655705 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2655328..2655705) Shigella dysenteriae Sd197 3796148 YP_404399.1 CDS insA NC_007606.1 2655750 2656025 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2655750..2656025) Shigella dysenteriae Sd197 3796149 YP_404400.1 CDS proV NC_007606.1 2656201 2657226 D Code: E; COG: COG4175; glycine, betaine and proline ABC transporter ATP-binding protein 2656201..2657226 Shigella dysenteriae Sd197 3799634 YP_404401.1 CDS proW NC_007606.1 2657219 2658283 D with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2657219..2658283 Shigella dysenteriae Sd197 3799635 YP_404402.1 CDS SDY_2874 NC_007606.1 2658396 2658791 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(2658396..2658791) Shigella dysenteriae Sd197 3799636 YP_009000807.1 CDS SDY_4732 NC_007606.1 2658818 2659090 R insertion element iso-IS1N protein InsA complement(2658818..2659090) Shigella dysenteriae Sd197 18263121 YP_404403.1 CDS SDY_2876 NC_007606.1 2660298 2661482 D major facilitator superfamily; Code: GEPR; COG: COG0477; permease 2660298..2661482 Shigella dysenteriae Sd197 3799638 YP_404404.1 CDS SDY_2877 NC_007606.1 2661606 2662343 D Code: E; COG: COG1296; hypothetical protein 2661606..2662343 Shigella dysenteriae Sd197 3799639 YP_404405.1 CDS ygaH NC_007606.1 2662333 2662668 D hypothetical protein 2662333..2662668 Shigella dysenteriae Sd197 3799640 YP_404406.1 CDS emrR NC_007606.1 2662759 2663289 D microcin B17 synthesis; DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2662759..2663289 Shigella dysenteriae Sd197 3799641 YP_404407.1 CDS emrA NC_007606.1 2663416 2664588 D Code: V; COG: COG1566; multidrug resistance secretion protein 2663416..2664588 Shigella dysenteriae Sd197 3799642 YP_404408.1 CDS SDY_2882 NC_007606.1 2666401 2667108 D hypothetical protein 2666401..2667108 Shigella dysenteriae Sd197 3799644 YP_404409.1 CDS SDY_2883 NC_007606.1 2667174 2668217 D Code: J; COG: COG0617; hypothetical protein 2667174..2668217 Shigella dysenteriae Sd197 3799645 YP_404410.1 CDS ygaG NC_007606.1 2668266 2668781 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(2668266..2668781) Shigella dysenteriae Sd197 3799646 YP_404411.1 CDS gshA NC_007606.1 2668931 2670487 R involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase complement(2668931..2670487) Shigella dysenteriae Sd197 3799647 YP_404413.1 CDS yqaB NC_007606.1 2670984 2671550 R ''YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent''; fructose-1-phosphatase complement(2670984..2671550) Shigella dysenteriae Sd197 3799649 YP_404414.1 CDS csrA NC_007606.1 2672733 2672918 R affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator complement(2672733..2672918) Shigella dysenteriae Sd197 3796619 YP_404415.1 CDS alaS NC_007606.1 2673153 2675783 R ''Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''; alanyl-tRNA synthetase complement(2673153..2675783) Shigella dysenteriae Sd197 3796620 YP_404416.1 CDS recX NC_007606.1 2675911 2676411 R regulator; binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(2675911..2676411) Shigella dysenteriae Sd197 3796621 YP_404417.1 CDS recA NC_007606.1 2676654 2677715 R DNA strand exchange and renaturation; ''catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs''; recombinase A complement(2676654..2677715) Shigella dysenteriae Sd197 3796622 YP_404418.1 CDS ygaD NC_007606.1 2677795 2678292 R Code: R; COG: COG1546; competence damage-inducible protein A complement(2677795..2678292) Shigella dysenteriae Sd197 3796623 YP_404419.1 CDS mltB NC_007606.1 2678438 2679523 R membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B complement(2678438..2679523) Shigella dysenteriae Sd197 3796624 YP_404420.1 CDS srlA NC_007606.1 2679779 2680342 D one of two; Code: G; COG: COG3730; PTS system glucitol/sorbitol-specific transporter subunit IIC 2679779..2680342 Shigella dysenteriae Sd197 3796625 YP_009000808.1 CDS SDY_4733 NC_007606.1 2681535 2681807 R insertion element iso-IS1N protein InsA complement(2681535..2681807) Shigella dysenteriae Sd197 18263122 YP_404422.1 CDS srlB NC_007606.1 2682083 2682454 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 2682083..2682454 Shigella dysenteriae Sd197 3796628 YP_404423.1 CDS srlD NC_007606.1 2682458 2683237 D catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2682458..2683237 Shigella dysenteriae Sd197 3796629 YP_404424.1 CDS gutM NC_007606.1 2683343 2683702 D regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2683343..2683702 Shigella dysenteriae Sd197 3796630 YP_404425.1 CDS srlR NC_007606.1 2683769 2684542 D regulator for gut (srl) operon; regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 2683769..2684542 Shigella dysenteriae Sd197 3796631 YP_404426.2 CDS gutQ NC_007606.1 2684535 2685500 D catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 2684535..2685500 Shigella dysenteriae Sd197 3796632 YP_404427.2 CDS ygaA NC_007606.1 2685497 2687011 R Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcriptional regulator complement(2685497..2687011) Shigella dysenteriae Sd197 3796633 YP_404428.1 CDS SDY_2907 NC_007606.1 2687198 2688637 D detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 2687198..2688637 Shigella dysenteriae Sd197 3796383 YP_404429.1 CDS ygbD NC_007606.1 2688634 2689767 D catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 2688634..2689767 Shigella dysenteriae Sd197 3796384 YP_404430.1 CDS hypF NC_007606.1 2689899 2692151 R Code: O; COG: COG0068; transcriptional regulator complement(2689899..2692151) Shigella dysenteriae Sd197 3796385 YP_404431.1 CDS ascG NC_007606.1 2692712 2693725 R Code: K; COG: COG1609; ascBF operon repressor complement(2692712..2693725) Shigella dysenteriae Sd197 3796387 YP_404432.1 CDS ascB NC_007606.1 2694840 2696264 D cryptic protein; Code: G; COG: COG2723; cryptic 6-phospho-beta-glucosidase 2694840..2696264 Shigella dysenteriae Sd197 3796388 YP_404433.1 CDS SDY_2913 NC_007606.1 2696379 2696864 R Code: K; COG: COG5499; hypothetical protein complement(2696379..2696864) Shigella dysenteriae Sd197 3796389 YP_404434.1 CDS hycI NC_007606.1 2697034 2697501 R protease involved in processing C-terminal end of the large subunit of hydrogenase 3; involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease complement(2697034..2697501) Shigella dysenteriae Sd197 3796390 YP_404435.1 CDS hycH NC_007606.1 2697494 2697904 R processing of large subunit (HycE) of hydrogenase 3 (part of the FHL complex); formate hydrogenlyase maturation protein HycH complement(2697494..2697904) Shigella dysenteriae Sd197 3796391 YP_404436.1 CDS hycF NC_007606.1 2698667 2699209 R part of FHL complex; ''electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate''; formate hydrogenlyase complex iron-sulfur subunit complement(2698667..2699209) Shigella dysenteriae Sd197 3796393 YP_404437.1 CDS hycE NC_007606.1 2699219 2700928 R part of FHL complex; Code: C; COG: COG3261; hydrogenase 3 large subunit complement(2699219..2700928) Shigella dysenteriae Sd197 3796394 YP_404439.1 CDS hycB NC_007606.1 2703737 2704348 R part of formate hydrogenlyase (FHL) complex; Code: C; COG: COG1142; hydrogenase-3 iron-sulfur small subunit complement(2703737..2704348) Shigella dysenteriae Sd197 3796397 YP_404440.1 CDS hycA NC_007606.1 2704473 2704934 R regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA complement(2704473..2704934) Shigella dysenteriae Sd197 3796398 YP_404441.1 CDS hypA NC_007606.1 2705146 2705496 D plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 2705146..2705496 Shigella dysenteriae Sd197 3796399 YP_404442.1 CDS hypB NC_007606.1 2705500 2706372 D functions as nickel donor for large subunit of hydrogenase 3; GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 2705500..2706372 Shigella dysenteriae Sd197 3796400 YP_404443.1 CDS hypC NC_007606.1 2706363 2706635 D ''HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase''; hydrogenase assembly chaperone 2706363..2706635 Shigella dysenteriae Sd197 3796401 YP_404444.1 CDS hypD NC_007606.1 2706635 2707756 D Code: O; COG: COG0409; hydrogenase expression/formation protein HypD 2706635..2707756 Shigella dysenteriae Sd197 3796402 YP_404445.1 CDS hypE NC_007606.1 2707795 2708763 D plays structural role in maturation of all 3 hydrogenases; Code: O; COG: COG0309; hypothetical protein 2707795..2708763 Shigella dysenteriae Sd197 3796501 YP_404446.1 CDS SDY_2929 NC_007606.1 2710642 2711355 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(2710642..2711355) Shigella dysenteriae Sd197 3796503 YP_404447.1 CDS SDY_2930 NC_007606.1 2711496 2711798 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(2711496..2711798) Shigella dysenteriae Sd197 3796504 YP_404448.1 CDS SDY_2931 NC_007606.1 2712202 2712645 D Code: R; COG: COG2005; molybdenum-pterin-binding-protein 2712202..2712645 Shigella dysenteriae Sd197 3796505 YP_404449.1 CDS ygbA NC_007606.1 2712684 2713028 R hypothetical protein complement(2712684..2713028) Shigella dysenteriae Sd197 3796506 YP_404450.1 CDS mutS NC_007606.1 2713315 2715876 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2713315..2715876 Shigella dysenteriae Sd197 3796507 YP_404451.1 CDS insB NC_007606.1 2715940 2716317 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2715940..2716317) Shigella dysenteriae Sd197 3796508 YP_404452.1 CDS insA NC_007606.1 2716362 2716637 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2716362..2716637) Shigella dysenteriae Sd197 3796509 YP_404453.1 CDS SDY_2936 NC_007606.1 2716734 2716970 R hypothetical protein complement(2716734..2716970) Shigella dysenteriae Sd197 3796510 YP_404455.1 CDS SDY_2938 NC_007606.1 2718407 2719000 R Code: H; COG: COG0163; phenylacrylic acid decarboxylase-like protein complement(2718407..2719000) Shigella dysenteriae Sd197 3796512 YP_404456.1 CDS SDY_2939 NC_007606.1 2719147 2719554 D Code: K; COG: COG1846; transcriptional regulator 2719147..2719554 Shigella dysenteriae Sd197 3796513 YP_404457.1 CDS rpoS NC_007606.1 2719674 2720666 R sigma38 factor; synthesis of many growth phase related proteins; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS complement(2719674..2720666) Shigella dysenteriae Sd197 3796514 YP_404458.1 CDS nlpD NC_007606.1 2720729 2721868 R outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD complement(2720729..2721868) Shigella dysenteriae Sd197 3796515 YP_404459.1 CDS pcm NC_007606.1 2722008 2722634 R catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase complement(2722008..2722634) Shigella dysenteriae Sd197 3796516 YP_404460.1 CDS surE NC_007606.1 2722628 2723389 R catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE complement(2722628..2723389) Shigella dysenteriae Sd197 3796517 YP_404461.1 CDS truD NC_007606.1 2723370 2724419 R catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D complement(2723370..2724419) Shigella dysenteriae Sd197 3796518 YP_404462.1 CDS ispF NC_007606.1 2724416 2724895 R ''catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate''; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(2724416..2724895) Shigella dysenteriae Sd197 3796519 YP_404463.1 CDS ispD NC_007606.1 2724895 2725605 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(2724895..2725605) Shigella dysenteriae Sd197 3796403 YP_404464.1 CDS ftsB NC_007606.1 2725624 2725935 R forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB complement(2725624..2725935) Shigella dysenteriae Sd197 3796404 YP_404465.1 CDS ygbE NC_007606.1 2726129 2726452 R hypothetical protein complement(2726129..2726452) Shigella dysenteriae Sd197 3796405 YP_404466.1 CDS cysC NC_007606.1 2726502 2727107 R converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase complement(2726502..2727107) Shigella dysenteriae Sd197 3796406 YP_404467.1 CDS cysN NC_007606.1 2727107 2728534 R ATP:sulfate adenylyltransferase; probably a GTPase; may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 complement(2727107..2728534) Shigella dysenteriae Sd197 3796407 YP_404468.1 CDS cysD NC_007606.1 2728536 2729444 R ATP:sulfate adenylyltransferase; probably a GTPase; with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 complement(2728536..2729444) Shigella dysenteriae Sd197 3796408 YP_404469.1 CDS iap NC_007606.1 2729697 2730734 D alkaline phosphatase isozyme conversion; catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase 2729697..2730734 Shigella dysenteriae Sd197 3796409 YP_404470.2 CDS ygbF NC_007606.1 2731133 2731417 R hypothetical protein complement(2731133..2731417) Shigella dysenteriae Sd197 3796410 YP_404472.1 CDS SDY_2955 NC_007606.1 2732352 2732951 R hypothetical protein complement(2732352..2732951) Shigella dysenteriae Sd197 3796412 YP_404473.1 CDS insA NC_007606.1 2733329 2733604 D Code: L; COG: COG3677; insertion element IS1 protein InsA 2733329..2733604 Shigella dysenteriae Sd197 3796413 YP_404474.1 CDS insB NC_007606.1 2733649 2734026 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2733649..2734026 Shigella dysenteriae Sd197 3796414 YP_404477.1 CDS SDY_2960 NC_007606.1 2735185 2735487 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 2735185..2735487 Shigella dysenteriae Sd197 3796417 YP_404478.1 CDS SDY_2961 NC_007606.1 2735628 2736440 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 2735628..2736440 Shigella dysenteriae Sd197 3796418 YP_404479.1 CDS insB NC_007606.1 2736469 2736846 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2736469..2736846) Shigella dysenteriae Sd197 3796419 YP_404480.1 CDS insA NC_007606.1 2736891 2737166 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2736891..2737166) Shigella dysenteriae Sd197 3796420 YP_404481.1 CDS cysH NC_007606.1 2737233 2737967 R catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase complement(2737233..2737967) Shigella dysenteriae Sd197 3796421 YP_404482.1 CDS cysI NC_007606.1 2738041 2739753 R hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta complement(2738041..2739753) Shigella dysenteriae Sd197 3796422 YP_404483.1 CDS cysJ NC_007606.1 2739753 2741552 R catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha complement(2739753..2741552) Shigella dysenteriae Sd197 3798041 YP_404484.1 CDS ygcM NC_007606.1 2741868 2742233 D Code: H; COG: COG0720; 6-pyruvoyl tetrahydrobiopterin synthase 2741868..2742233 Shigella dysenteriae Sd197 3798042 YP_404485.1 CDS ygcN NC_007606.1 2742281 2743582 D Code: C; COG: COG0644; hypothetical protein 2742281..2743582 Shigella dysenteriae Sd197 3798043 YP_404486.1 CDS ygcO NC_007606.1 2743537 2743833 D Code: C; COG: COG2440; hypothetical protein 2743537..2743833 Shigella dysenteriae Sd197 3798044 YP_404487.1 CDS ygcP NC_007606.1 2743850 2744425 D Code: K; COG: COG1954; anti-terminator regulatory protein 2743850..2744425 Shigella dysenteriae Sd197 3798045 YP_404488.1 CDS ygcS NC_007606.1 2746187 2747596 R Code: GEPR; COG: COG0477; transport protein complement(2746187..2747596) Shigella dysenteriae Sd197 3798048 YP_404490.1 CDS SDY_2975 NC_007606.1 2749115 2749510 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(2749115..2749510) Shigella dysenteriae Sd197 3798050 YP_009000809.1 CDS SDY_4734 NC_007606.1 2749537 2749809 R insertion element iso-IS1N protein InsA complement(2749537..2749809) Shigella dysenteriae Sd197 18263123 YP_404491.1 CDS ygcW NC_007606.1 2749916 2750701 R Code: IQR; COG: COG1028; oxidoreductase complement(2749916..2750701) Shigella dysenteriae Sd197 3798051 YP_404492.1 CDS ygcE NC_007606.1 2752322 2753800 D Code: G; COG: COG1070; kinase 2752322..2753800 Shigella dysenteriae Sd197 3798053 YP_404493.2 CDS SDY_2979 NC_007606.1 2753973 2754878 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(2753973..2754878) Shigella dysenteriae Sd197 3798054 YP_404494.1 CDS SDY_2980 NC_007606.1 2754836 2755201 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(2754836..2755201) Shigella dysenteriae Sd197 3798055 YP_404495.1 CDS ygcF NC_007606.1 2755549 2756220 R Code: O; COG: COG0602; hypothetical protein complement(2755549..2756220) Shigella dysenteriae Sd197 3798056 YP_009000810.1 CDS SDY_4735 NC_007606.1 2756464 2756736 D insertion element iso-IS1N protein InsA 2756464..2756736 Shigella dysenteriae Sd197 18263124 YP_404497.1 CDS SDY_2983 NC_007606.1 2756763 2757158 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2756763..2757158 Shigella dysenteriae Sd197 3798058 YP_404500.1 CDS SDY_2986 NC_007606.1 2757727 2758122 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2757727..2758122) Shigella dysenteriae Sd197 3797388 YP_009000811.1 CDS SDY_4736 NC_007606.1 2758149 2758421 R insertion element iso-IS1N protein InsA complement(2758149..2758421) Shigella dysenteriae Sd197 18263125 YP_404501.1 CDS SDY_2987 NC_007606.1 2758535 2758837 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 2758535..2758837 Shigella dysenteriae Sd197 3797389 YP_404504.1 CDS SDY_2990 NC_007606.1 2760150 2760452 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(2760150..2760452) Shigella dysenteriae Sd197 3797392 YP_404506.1 CDS SDY_2992 NC_007606.1 2760757 2761467 D Code: R; COG: COG1512; hypothetical protein 2760757..2761467 Shigella dysenteriae Sd197 3797394 YP_404507.1 CDS insB NC_007606.1 2761461 2761838 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2761461..2761838) Shigella dysenteriae Sd197 3797395 YP_404508.1 CDS insA NC_007606.1 2761883 2762158 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2761883..2762158) Shigella dysenteriae Sd197 3797396 YP_404509.1 CDS SDY_2995 NC_007606.1 2762297 2762563 D hypothetical protein 2762297..2762563 Shigella dysenteriae Sd197 3797397 YP_404510.1 CDS eno NC_007606.1 2762623 2763921 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(2762623..2763921) Shigella dysenteriae Sd197 3797398 YP_404511.1 CDS pyrG NC_007606.1 2764009 2765646 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(2764009..2765646) Shigella dysenteriae Sd197 3797399 YP_404512.1 CDS mazG NC_007606.1 2765869 2766660 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase complement(2765869..2766660) Shigella dysenteriae Sd197 3797400 YP_404513.1 CDS chpA NC_007606.1 2766731 2767066 R autoregulated; MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA complement(2766731..2767066) Shigella dysenteriae Sd197 3797401 YP_404514.1 CDS chpR NC_007606.1 2767066 2767314 R autoregulated; part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE complement(2767066..2767314) Shigella dysenteriae Sd197 3797402 YP_404515.1 CDS relA NC_007606.1 2767392 2769626 R GTP pyrophosphokinase; regulation of RNA synthesis; stringent factor; (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase complement(2767392..2769626) Shigella dysenteriae Sd197 3797403 YP_404516.1 CDS rumA NC_007606.1 2769674 2770975 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(2769674..2770975) Shigella dysenteriae Sd197 3797404 YP_404517.1 CDS barA NC_007606.1 2771032 2773788 D activates OmpR by phophorylation; part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 2771032..2773788 Shigella dysenteriae Sd197 3797405 YP_404518.1 CDS SDY_3007 NC_007606.1 2778498 2778947 R ''An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group''; flavodoxin complement(2778498..2778947) Shigella dysenteriae Sd197 3796346 YP_404519.1 CDS yqcB NC_007606.1 2778965 2779747 R catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C complement(2778965..2779747) Shigella dysenteriae Sd197 3796347 YP_404520.1 CDS SDY_3009 NC_007606.1 2779747 2780076 R Code: S; COG: COG3098; hypothetical protein complement(2779747..2780076) Shigella dysenteriae Sd197 3796348 YP_404521.1 CDS syd NC_007606.1 2780698 2781243 R interacts with secY; SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd complement(2780698..2781243) Shigella dysenteriae Sd197 3796349 YP_404522.1 CDS queF NC_007606.1 2781311 2782159 D catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 2781311..2782159 Shigella dysenteriae Sd197 3796350 YP_404523.1 CDS ygdH NC_007606.1 2782271 2783635 D Code: R; COG: COG1611; hypothetical protein 2782271..2783635 Shigella dysenteriae Sd197 3796351 YP_404524.1 CDS sdaC NC_007606.1 2784192 2785481 D Code: E; COG: COG0814; serine transporter 2784192..2785481 Shigella dysenteriae Sd197 3796352 YP_404525.1 CDS sdaB NC_007606.1 2785539 2786906 D deaminase, L-SD2; Code: E; COG: COG1760; L-serine dehydratase 2785539..2786906 Shigella dysenteriae Sd197 3796353 YP_404526.1 CDS xni NC_007606.1 2786928 2787773 D has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 2786928..2787773 Shigella dysenteriae Sd197 3796354 YP_404527.1 CDS fucO NC_007606.1 2787828 2788979 R Code: C; COG: COG1454; L-1,2-propanediol oxidoreductase complement(2787828..2788979) Shigella dysenteriae Sd197 3796355 YP_404528.1 CDS fucA NC_007606.1 2789004 2789651 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(2789004..2789651) Shigella dysenteriae Sd197 3796356 YP_404529.1 CDS SDY_3019 NC_007606.1 2791116 2791511 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2791116..2791511 Shigella dysenteriae Sd197 3796358 YP_404530.1 CDS fucI NC_007606.1 2792322 2794097 D catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2792322..2794097 Shigella dysenteriae Sd197 3796359 YP_404531.1 CDS fucK NC_007606.1 2794176 2795624 D Code: G; COG: COG1070; L-fuculokinase 2794176..2795624 Shigella dysenteriae Sd197 3796360 YP_404532.1 CDS fucU NC_007606.1 2795626 2796048 D Code: G; COG: COG4154; L-fucose mutarotase 2795626..2796048 Shigella dysenteriae Sd197 3796361 YP_404533.1 CDS fucR NC_007606.1 2796106 2796837 D regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 2796106..2796837 Shigella dysenteriae Sd197 3796362 YP_404534.1 CDS ygdE NC_007606.1 2796881 2797981 R Code: R; COG: COG2933; RNA 2'-O-ribose methyltransferase complement(2796881..2797981) Shigella dysenteriae Sd197 3796113 YP_404535.1 CDS ygdD NC_007606.1 2797974 2798369 R Code: S; COG: COG2363; hypothetical protein complement(2797974..2798369) Shigella dysenteriae Sd197 3796114 YP_404536.1 CDS gcvA NC_007606.1 2798388 2799305 R Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA complement(2798388..2799305) Shigella dysenteriae Sd197 3796115 YP_404537.1 CDS SDY_3027 NC_007606.1 2799656 2799886 R hypothetical protein complement(2799656..2799886) Shigella dysenteriae Sd197 3796116 YP_404538.1 CDS SDY_3028 NC_007606.1 2800075 2801280 D Code: E; COG: COG0520; cysteine sulfinate desulfinase 2800075..2801280 Shigella dysenteriae Sd197 3796117 YP_404539.1 CDS ygdK NC_007606.1 2801280 2801723 D Code: R; COG: COG2166; hypothetical protein 2801280..2801723 Shigella dysenteriae Sd197 3796118 YP_404540.1 CDS ygdL NC_007606.1 2801774 2802580 R Code: H; COG: COG1179; sulfur acceptor protein CsdL complement(2801774..2802580) Shigella dysenteriae Sd197 3796119 YP_404541.1 CDS mltA NC_007606.1 2802819 2803916 R ''membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues''; murein transglycosylase A complement(2802819..2803916) Shigella dysenteriae Sd197 3796120 YP_404542.1 CDS SDY_3034 NC_007606.1 2804385 2805728 R Code: M; COG: COG0860; amidase complement(2804385..2805728) Shigella dysenteriae Sd197 3796123 YP_404543.1 CDS argA NC_007606.1 2805870 2807201 D amino acid acetyltransferase; catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 2805870..2807201 Shigella dysenteriae Sd197 3796124 YP_404544.1 CDS recD NC_007606.1 2807263 2809089 R DNA helicase; ssDNA endonuclease; helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha complement(2807263..2809089) Shigella dysenteriae Sd197 3796125 YP_404545.1 CDS recB NC_007606.1 2809089 2812631 R DNA helicase; ssDNA endonuclease; helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta complement(2809089..2812631) Shigella dysenteriae Sd197 3796126 YP_404546.1 CDS ptr NC_007606.1 2812624 2815512 R Code: O; COG: COG1025; protease III complement(2812624..2815512) Shigella dysenteriae Sd197 3796127 YP_404547.1 CDS recC NC_007606.1 2815688 2819056 R DNA helicase; ssDNA endonuclease; catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma complement(2815688..2819056) Shigella dysenteriae Sd197 3796128 YP_404548.1 CDS ppdC NC_007606.1 2819069 2819392 R Code: NU; COG: COG4967; hypothetical protein complement(2819069..2819392) Shigella dysenteriae Sd197 3796129 YP_404549.2 CDS ygdB NC_007606.1 2819377 2819784 R hypothetical protein complement(2819377..2819784) Shigella dysenteriae Sd197 3796130 YP_404550.1 CDS ppdB NC_007606.1 2819781 2820344 R Code: U; COG: COG4795; hypothetical protein complement(2819781..2820344) Shigella dysenteriae Sd197 3795925 YP_404551.1 CDS ppdA NC_007606.1 2820335 2820805 R Code: NU; COG: COG2165; hypothetical protein complement(2820335..2820805) Shigella dysenteriae Sd197 3795926 YP_404552.1 CDS thyA NC_007606.1 2820990 2821784 R ''ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived''; thymidylate synthase complement(2820990..2821784) Shigella dysenteriae Sd197 3795927 YP_404553.1 CDS lgt NC_007606.1 2821791 2822666 R a major membrane phospholipid; transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(2821791..2822666) Shigella dysenteriae Sd197 3795928 YP_404554.1 CDS ptsP NC_007606.1 2822818 2825064 R member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain complement(2822818..2825064) Shigella dysenteriae Sd197 3795929 YP_404555.1 CDS ygdP NC_007606.1 2825077 2825607 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(2825077..2825607) Shigella dysenteriae Sd197 3795930 YP_404556.1 CDS mutH NC_007606.1 2826292 2826981 D MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 2826292..2826981 Shigella dysenteriae Sd197 3795931 YP_404557.1 CDS SDY_3049 NC_007606.1 2827050 2827763 D Code: P; COG: COG0861; transport protein 2827050..2827763 Shigella dysenteriae Sd197 3795932 YP_404558.1 CDS SDY_3050 NC_007606.1 2827901 2828119 D hypothetical protein 2827901..2828119 Shigella dysenteriae Sd197 3795933 YP_404559.1 CDS tas NC_007606.1 2828227 2829267 D complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo-keto reductase 2828227..2829267 Shigella dysenteriae Sd197 3795934 YP_404560.1 CDS ygeD NC_007606.1 2829299 2830492 R Code: GEPR; COG: COG0477; lysophospholipid transporter LplT complement(2829299..2830492) Shigella dysenteriae Sd197 3795935 YP_404561.1 CDS aas NC_007606.1 2830485 2832644 R acyl-acyl-carrier protein synthetase; Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase complement(2830485..2832644) Shigella dysenteriae Sd197 3795936 YP_404562.1 CDS galR NC_007606.1 2833230 2834261 D controls transcription of galETKM; DNA-binding transcriptional regulator GalR 2833230..2834261 Shigella dysenteriae Sd197 3795937 YP_404563.1 CDS lysA NC_007606.1 2834268 2835530 R catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase complement(2834268..2835530) Shigella dysenteriae Sd197 3795938 YP_404564.1 CDS lysR NC_007606.1 2835652 2836587 D activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; LysR family transcriptional regulator 2835652..2836587 Shigella dysenteriae Sd197 3795939 YP_404565.1 CDS ygeA NC_007606.1 2836574 2837257 R Code: M; COG: COG1794; racemase complement(2836574..2837257) Shigella dysenteriae Sd197 3795940 YP_404566.1 CDS araE NC_007606.1 2837386 2838615 R Code: GEPR; COG: COG0477; low-affinity L-arabinose transport system proton symport protein complement(2837386..2838615) Shigella dysenteriae Sd197 3795941 YP_404567.1 CDS insB NC_007606.1 2838863 2839240 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2838863..2839240) Shigella dysenteriae Sd197 3795942 YP_404568.1 CDS insA NC_007606.1 2839285 2839560 R Code: L; COG: COG3677; insertion element iso-IS1d protein InsA complement(2839285..2839560) Shigella dysenteriae Sd197 3795943 YP_404569.2 CDS dkgA NC_007606.1 2839759 2840586 R ''methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate''; 2,5-diketo-D-gluconate reductase A complement(2839759..2840586) Shigella dysenteriae Sd197 3796059 YP_404570.1 CDS yqhD NC_007606.1 2840691 2841854 R Code: C; COG: COG1979; oxidoreductase complement(2840691..2841854) Shigella dysenteriae Sd197 3796061 YP_404571.1 CDS yqhC NC_007606.1 2841820 2842947 D Code: K; COG: COG2207; AraC family transcriptional regulator 2841820..2842947 Shigella dysenteriae Sd197 3796060 YP_404572.1 CDS yghB NC_007606.1 2842987 2843646 R Code: S; COG: COG0586; hypothetical protein complement(2842987..2843646) Shigella dysenteriae Sd197 3796062 YP_404573.1 CDS metC NC_007606.1 2843787 2844974 R beta-cystathionase; catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase complement(2843787..2844974) Shigella dysenteriae Sd197 3796063 YP_404574.1 CDS SDY_3066 NC_007606.1 2845078 2845233 D hypothetical protein 2845078..2845233 Shigella dysenteriae Sd197 3796064 YP_404575.1 CDS exbB NC_007606.1 2845226 2845960 D uptake of enterochelin; tonB-dependent uptake of B colicins; membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 2845226..2845960 Shigella dysenteriae Sd197 3796065 YP_404576.1 CDS exbD NC_007606.1 2845967 2846392 D uptake of enterochelin; tonB-dependent uptake of B colicins; membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 2845967..2846392 Shigella dysenteriae Sd197 3796066 YP_404577.1 CDS yghA NC_007606.1 2846431 2847315 R Code: IQR; COG: COG1028; oxidoreductase complement(2846431..2847315) Shigella dysenteriae Sd197 3796067 YP_404578.1 CDS yqhA NC_007606.1 2847506 2848000 D Code: S; COG: COG2862; hypothetical protein 2847506..2848000 Shigella dysenteriae Sd197 3796068 YP_404579.1 CDS insB NC_007606.1 2848300 2848677 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2848300..2848677) Shigella dysenteriae Sd197 3796069 YP_404580.1 CDS insA NC_007606.1 2848722 2848997 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2848722..2848997) Shigella dysenteriae Sd197 3796070 YP_404581.1 CDS SDY_3073 NC_007606.1 2849048 2849857 R Code: C; COG: COG0667; reductase complement(2849048..2849857) Shigella dysenteriae Sd197 3796071 YP_404582.1 CDS SDY_3075 NC_007606.1 2851021 2851308 D hypothetical protein 2851021..2851308 Shigella dysenteriae Sd197 3796073 YP_404583.1 CDS SDY_3076 NC_007606.1 2851497 2852615 D involved in hydrogen uptake; hydrogenase 2 small subunit 2851497..2852615 Shigella dysenteriae Sd197 3796074 YP_404584.1 CDS hybA NC_007606.1 2852618 2853604 D Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 2852618..2853604 Shigella dysenteriae Sd197 3796075 YP_404585.1 CDS hybB NC_007606.1 2853594 2854772 D ''HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits''; hydrogenase 2 b cytochrome subunit 2853594..2854772 Shigella dysenteriae Sd197 3796076 YP_404586.1 CDS hybC NC_007606.1 2854769 2856472 D involved in hydrogen uptake; hydrogenase 2 large subunit 2854769..2856472 Shigella dysenteriae Sd197 3796077 YP_404587.1 CDS hybD NC_007606.1 2856472 2856966 D protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 2856472..2856966 Shigella dysenteriae Sd197 3796078 YP_404588.1 CDS hybE NC_007606.1 2856959 2857447 D hydrogenase 2-specific chaperone 2856959..2857447 Shigella dysenteriae Sd197 3799729 YP_404589.1 CDS hybF NC_007606.1 2857440 2857781 D may modulate levels of hydrogenase-2; plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 2857440..2857781 Shigella dysenteriae Sd197 3799730 YP_404590.1 CDS hybG NC_007606.1 2857794 2858042 D may effect maturation of large subunit of hydrogenase-2; Code: O; COG: COG0298; hydrogenase 2 accessory protein HypG 2857794..2858042 Shigella dysenteriae Sd197 3799731 YP_404591.1 CDS SDY_3084 NC_007606.1 2858165 2859079 R YghU; B2989; one of eight glutathione transferases from E. coli; glutathione S-transferase YghU complement(2858165..2859079) Shigella dysenteriae Sd197 3799732 YP_404592.1 CDS gsp NC_007606.1 2859236 2861095 D catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 2859236..2861095 Shigella dysenteriae Sd197 3799733 YP_404593.1 CDS pitB NC_007606.1 2861387 2862886 D Code: P; COG: COG0306; low-affinity phosphate transport protein 2861387..2862886 Shigella dysenteriae Sd197 3799734 YP_404594.1 CDS yghT NC_007606.1 2862935 2863639 R hypothetical protein complement(2862935..2863639) Shigella dysenteriae Sd197 3799735 YP_404595.1 CDS insA NC_007606.1 2863681 2863956 D Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 2863681..2863956 Shigella dysenteriae Sd197 3799736 YP_404596.1 CDS SDY_3089 NC_007606.1 2864313 2865290 R Code: MG; COG: COG0702; hypothetical protein complement(2864313..2865290) Shigella dysenteriae Sd197 3799737 YP_404597.2 CDS SDY_3090 NC_007606.1 2865287 2866975 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(2865287..2866975) Shigella dysenteriae Sd197 3799738 YP_404598.1 CDS SDY_3091 NC_007606.1 2867021 2867416 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2867021..2867416) Shigella dysenteriae Sd197 3799739 YP_009000812.1 CDS SDY_4737 NC_007606.1 2867443 2867715 R insertion element iso-IS1N protein InsA complement(2867443..2867715) Shigella dysenteriae Sd197 18263126 YP_404599.1 CDS gspC NC_007606.1 2867995 2868825 D ''part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm''; type II secretion protein GspC 2867995..2868825 Shigella dysenteriae Sd197 3799740 YP_404600.1 CDS gspD NC_007606.1 2869065 2870900 D Code: NU; COG: COG1450; type II secretion protein 2869065..2870900 Shigella dysenteriae Sd197 3799741 YP_404601.1 CDS gspE NC_007606.1 2870900 2872393 D Code: NU; COG: COG2804; type II secretion protein 2870900..2872393 Shigella dysenteriae Sd197 3799742 YP_404602.1 CDS gspF NC_007606.1 2872393 2873592 D Code: NU; COG: COG1459; type II secretion protein 2872393..2873592 Shigella dysenteriae Sd197 3799743 YP_404603.1 CDS gspG NC_007606.1 2873633 2874088 D Code: NU; COG: COG2165; type II secretion protein 2873633..2874088 Shigella dysenteriae Sd197 3799744 YP_404604.1 CDS gspH NC_007606.1 2874125 2874655 D type II secretion protein 2874125..2874655 Shigella dysenteriae Sd197 3799745 YP_404605.1 CDS gspI NC_007606.1 2874652 2875023 D Code: NU; COG: COG2165; type II secretion protein 2874652..2875023 Shigella dysenteriae Sd197 3799746 YP_404606.1 CDS gspJ NC_007606.1 2875056 2875625 D Code: U; COG: COG4795; type II secretion protein 2875056..2875625 Shigella dysenteriae Sd197 3799747 YP_404607.1 CDS gspK NC_007606.1 2875622 2876599 D Code: U; COG: COG3156; type II secretion protein 2875622..2876599 Shigella dysenteriae Sd197 3799035 YP_404608.1 CDS gspL NC_007606.1 2876914 2877774 D similar to general secretory pathway protein L; GspL-like protein 2876914..2877774 Shigella dysenteriae Sd197 3799036 YP_404610.1 CDS insA NC_007606.1 2879112 2879387 D Code: L; COG: COG3677; insertion element IS1 protein InsA 2879112..2879387 Shigella dysenteriae Sd197 3799039 YP_404611.1 CDS insB NC_007606.1 2879432 2879809 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2879432..2879809 Shigella dysenteriae Sd197 3799040 YP_404612.1 CDS speC NC_007606.1 2880516 2882651 D Code: E; COG: COG1982; ornithine decarboxylase 2880516..2882651 Shigella dysenteriae Sd197 3799042 YP_404613.1 CDS nupG NC_007606.1 2882701 2884005 R permease; Code: GEPR; COG: COG0477; nucleosides transporter complement(2882701..2884005) Shigella dysenteriae Sd197 3799043 YP_404614.1 CDS mltC NC_007606.1 2884159 2885241 R ''Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues''; murein transglycosylase C complement(2884159..2885241) Shigella dysenteriae Sd197 3799044 YP_404615.1 CDS yggX NC_007606.1 2885303 2885578 R Code: CO; COG: COG2924; hypothetical protein complement(2885303..2885578) Shigella dysenteriae Sd197 3799045 YP_404616.1 CDS mutY NC_007606.1 2885606 2886658 R G.C --> T.A transversions; Code: L; COG: COG1194; adenine DNA glycosylase complement(2885606..2886658) Shigella dysenteriae Sd197 3799046 YP_404617.1 CDS trmB NC_007606.1 2886819 2887538 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 2886819..2887538 Shigella dysenteriae Sd197 3799047 YP_404618.2 CDS yggL NC_007606.1 2887538 2887864 D Code: S; COG: COG3171; hypothetical protein 2887538..2887864 Shigella dysenteriae Sd197 3799048 YP_404619.1 CDS yggN NC_007606.1 2888048 2888767 D hypothetical protein 2888048..2888767 Shigella dysenteriae Sd197 3799049 YP_404620.1 CDS ansB NC_007606.1 2888943 2889989 D ''catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis''; L-asparaginase II 2888943..2889989 Shigella dysenteriae Sd197 3799050 YP_404621.1 CDS yggM NC_007606.1 2890106 2891113 D alpha helix chain 2890106..2891113 Shigella dysenteriae Sd197 3799051 YP_404622.1 CDS yggW NC_007606.1 2891265 2892401 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(2891265..2892401) Shigella dysenteriae Sd197 3799052 YP_404623.1 CDS yggV NC_007606.1 2892394 2892987 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase complement(2892394..2892987) Shigella dysenteriae Sd197 3799053 YP_404624.2 CDS yggU NC_007606.1 2892995 2893285 R Code: S; COG: COG1872; hypothetical protein complement(2892995..2893285) Shigella dysenteriae Sd197 3798997 YP_404625.1 CDS yggT NC_007606.1 2893282 2893848 R Code: S; COG: COG0762; resistance protein complement(2893282..2893848) Shigella dysenteriae Sd197 3798998 YP_404626.1 CDS yggS NC_007606.1 2893866 2894570 R Code: R; COG: COG0325; hypothetical protein complement(2893866..2894570) Shigella dysenteriae Sd197 3799000 YP_404627.1 CDS yggR NC_007606.1 2894543 2895568 D Code: NU; COG: COG2805; pilus retraction ATPase PilT 2894543..2895568 Shigella dysenteriae Sd197 3798999 YP_404628.1 CDS yqgF NC_007606.1 2895757 2896173 R similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein complement(2895757..2896173) Shigella dysenteriae Sd197 3799001 YP_404629.2 CDS yqgE NC_007606.1 2896173 2896736 R Code: K; COG: COG1678; hypothetical protein complement(2896173..2896736) Shigella dysenteriae Sd197 3799002 YP_404630.1 CDS gshB NC_007606.1 2896845 2897795 R ''The second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione''; glutathione synthetase complement(2896845..2897795) Shigella dysenteriae Sd197 3799003 YP_404631.2 CDS yggJ NC_007606.1 2897808 2898539 R ''in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase''; 16S ribosomal RNA methyltransferase RsmE complement(2897808..2898539) Shigella dysenteriae Sd197 3799004 YP_404632.1 CDS endA NC_007606.1 2898619 2899326 R Code: L; COG: COG2356; DNA-specific endonuclease I complement(2898619..2899326) Shigella dysenteriae Sd197 3799005 YP_404633.1 CDS sprT NC_007606.1 2899421 2899918 R Code: S; COG: COG3091; hypothetical protein complement(2899421..2899918) Shigella dysenteriae Sd197 3799006 YP_404634.1 CDS galP NC_007606.1 2899995 2901389 R Code: GEPR; COG: COG0477; galactose-proton symporter complement(2899995..2901389) Shigella dysenteriae Sd197 3799007 YP_404635.1 CDS metK NC_007606.1 2901826 2902980 R AdoMet synthetase; methyl and propylamine donor, corepressor of met genes; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase complement(2901826..2902980) Shigella dysenteriae Sd197 3799008 YP_404636.1 CDS yqgD NC_007606.1 2903036 2903287 D hypothetical protein 2903036..2903287 Shigella dysenteriae Sd197 3799009 YP_404637.1 CDS yqgC NC_007606.1 2903284 2903499 R hypothetical protein complement(2903284..2903499) Shigella dysenteriae Sd197 3799010 YP_404638.1 CDS yqgB NC_007606.1 2903620 2903766 D hypothetical protein 2903620..2903766 Shigella dysenteriae Sd197 3799011 YP_404639.1 CDS speA NC_007606.1 2903775 2905751 D catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 2903775..2905751 Shigella dysenteriae Sd197 3799012 YP_404640.1 CDS SDY_3135 NC_007606.1 2905897 2906169 D hypothetical protein 2905897..2906169 Shigella dysenteriae Sd197 3799013 YP_009000813.1 CDS SDY_4738 NC_007606.1 2906209 2906481 D insertion element iso-IS1N protein InsA 2906209..2906481 Shigella dysenteriae Sd197 18263127 YP_404642.1 CDS SDY_3137 NC_007606.1 2906508 2906903 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2906508..2906903 Shigella dysenteriae Sd197 3799015 YP_404643.1 CDS SDY_3138 NC_007606.1 2907035 2907409 D lipoprotein 2907035..2907409 Shigella dysenteriae Sd197 3795388 YP_404644.1 CDS speB NC_007606.1 2907545 2908465 D catalyzes the formation of putrescine from agmatine; agmatinase 2907545..2908465 Shigella dysenteriae Sd197 3795389 YP_404645.1 CDS yggG NC_007606.1 2908513 2909271 R Code: O; COG: COG0501; hypothetical protein complement(2908513..2909271) Shigella dysenteriae Sd197 3795390 YP_404646.1 CDS tktA NC_007606.1 2909549 2911540 D ''catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase''; transketolase 2909549..2911540 Shigella dysenteriae Sd197 3795391 YP_404647.1 CDS SDY_3142 NC_007606.1 2911856 2912251 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2911856..2912251) Shigella dysenteriae Sd197 3795392 YP_009000814.1 CDS SDY_4739 NC_007606.1 2912278 2912550 R insertion element iso-IS1N protein InsA complement(2912278..2912550) Shigella dysenteriae Sd197 18263128 YP_404648.1 CDS cmtB NC_007606.1 2912628 2913071 D ''TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein''; PTS system mannitol transporter subunit IIA 2912628..2913071 Shigella dysenteriae Sd197 3795393 YP_404649.1 CDS cmtA NC_007606.1 2913099 2914487 D Code: G; COG: COG2213; cryptic PTS system mannitol-specific transporter subunit IIBC 2913099..2914487 Shigella dysenteriae Sd197 3795394 YP_404650.2 CDS SDY_3145 NC_007606.1 2914502 2915779 D Code: ER; COG: COG1063; oxidoreductase 2914502..2915779 Shigella dysenteriae Sd197 3795395 YP_404651.1 CDS yggD NC_007606.1 2916763 2917272 D Code: K; COG: COG3722; DNA-binding transcriptional regulator 2916763..2917272 Shigella dysenteriae Sd197 3795397 YP_404652.1 CDS frcK NC_007606.1 2917269 2917982 D Code: H; COG: COG1072; fructose transport system kinase 2917269..2917982 Shigella dysenteriae Sd197 3795398 YP_404653.1 CDS SDY_3149 NC_007606.1 2917954 2918631 R Code: P; COG: COG1118; ABC transporter ATP-binding protein complement(2917954..2918631) Shigella dysenteriae Sd197 3795399 YP_404656.1 CDS SDY_3152 NC_007606.1 2919290 2919997 R Code: P; COG: COG0619; hypothetical protein complement(2919290..2919997) Shigella dysenteriae Sd197 3795402 YP_404657.1 CDS SDY_3153 NC_007606.1 2919998 2920576 R hypothetical protein complement(2919998..2920576) Shigella dysenteriae Sd197 3795403 YP_404658.1 CDS SDY_3154 NC_007606.1 2920599 2921030 R Code: R; COG: COG1661; hypothetical protein complement(2920599..2921030) Shigella dysenteriae Sd197 3795404 YP_404659.1 CDS epd NC_007606.1 2921402 2922421 D NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 2921402..2922421 Shigella dysenteriae Sd197 3795405 YP_404660.1 CDS pgk NC_007606.1 2922471 2923634 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 2922471..2923634 Shigella dysenteriae Sd197 3795406 YP_404661.1 CDS fba NC_007606.1 2923849 2924928 D ''catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate''; fructose-bisphosphate aldolase 2923849..2924928 Shigella dysenteriae Sd197 3795407 YP_404662.1 CDS yggB NC_007606.1 2925119 2925979 D participates in the regulation of osmotic pressure changes within the cel; mechanosensitive ion channel MscS 2925119..2925979 Shigella dysenteriae Sd197 3795558 YP_404663.1 CDS yggA NC_007606.1 2926118 2926753 D Involved in the export of arginine; arginine exporter protein 2926118..2926753 Shigella dysenteriae Sd197 3795559 YP_404664.1 CDS yggE NC_007606.1 2926846 2927586 D Code: S; COG: COG2968; hypothetical protein 2926846..2927586 Shigella dysenteriae Sd197 3795560 YP_009000815.1 CDS SDY_4740 NC_007606.1 2927835 2928107 D insertion element iso-IS1N protein InsA 2927835..2928107 Shigella dysenteriae Sd197 18263129 YP_404666.1 CDS SDY_3162 NC_007606.1 2928134 2928529 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2928134..2928529 Shigella dysenteriae Sd197 3795562 YP_404668.1 CDS iciA NC_007606.1 2931985 2932878 R binds to 13-mers at oriC; specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein complement(2931985..2932878) Shigella dysenteriae Sd197 3795565 YP_404669.1 CDS SDY_3166 NC_007606.1 2932990 2933385 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2932990..2933385) Shigella dysenteriae Sd197 3795566 YP_009000816.1 CDS SDY_4741 NC_007606.1 2933412 2933684 R insertion element iso-IS1N protein InsA complement(2933412..2933684) Shigella dysenteriae Sd197 18263130 YP_404671.1 CDS rpiA NC_007606.1 2934073 2934732 D Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 2934073..2934732 Shigella dysenteriae Sd197 3795568 YP_404672.1 CDS serA NC_007606.1 2934988 2936220 D catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 2934988..2936220 Shigella dysenteriae Sd197 3795569 YP_404673.1 CDS ygfA NC_007606.1 2936601 2937149 R ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase complement(2936601..2937149) Shigella dysenteriae Sd197 3795570 YP_404674.1 CDS ygfE NC_007606.1 2937449 2937778 R Code: S; COG: COG3027; Z-ring-associated protein complement(2937449..2937778) Shigella dysenteriae Sd197 3795571 YP_404675.2 CDS ygfB NC_007606.1 2937946 2938524 D the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 2937946..2938524 Shigella dysenteriae Sd197 3795572 YP_404676.1 CDS pepP NC_007606.1 2938550 2939875 D exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 2938550..2939875 Shigella dysenteriae Sd197 3795573 YP_404677.1 CDS ubiH NC_007606.1 2939872 2941050 D 2-octaprenyl-6-methoxyphenol--> 2-octaprenyl-6-methoxy-1, 4-benzoquinone; ''Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone''; 2-octaprenyl-6-methoxyphenyl hydroxylase 2939872..2941050 Shigella dysenteriae Sd197 3795574 YP_404678.1 CDS visC NC_007606.1 2941073 2942275 D Code: HC; COG: COG0654; hypothetical protein 2941073..2942275 Shigella dysenteriae Sd197 3795575 YP_404679.1 CDS gcvT NC_007606.1 2942723 2943817 D T protein; tetrahydrofolate-dependent; ''catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein''; glycine cleavage system aminomethyltransferase T 2942723..2943817 Shigella dysenteriae Sd197 3795576 YP_404680.1 CDS gcvH NC_007606.1 2943841 2944230 D ''part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor''; glycine cleavage system protein H 2943841..2944230 Shigella dysenteriae Sd197 3796002 YP_404681.1 CDS gcvP NC_007606.1 2944348 2947221 D P protein of glycine cleavage system; acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 2944348..2947221 Shigella dysenteriae Sd197 3796003 YP_404682.1 CDS yqfB NC_007606.1 2949765 2950076 D Code: S; COG: COG3097; hypothetical protein 2949765..2950076 Shigella dysenteriae Sd197 3796006 YP_404683.1 CDS SDY_3182 NC_007606.1 2950325 2950720 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(2950325..2950720) Shigella dysenteriae Sd197 3796007 YP_009000817.1 CDS SDY_4742 NC_007606.1 2950747 2951019 R insertion element iso-IS1N protein InsA complement(2950747..2951019) Shigella dysenteriae Sd197 18263131 YP_404684.1 CDS SDY_3183 NC_007606.1 2950999 2951673 D Code: R; COG: COG1272; oxidoreductase 2950999..2951673 Shigella dysenteriae Sd197 3796008 YP_404685.1 CDS ygfZ NC_007606.1 2951750 2952730 R physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator complement(2951750..2952730) Shigella dysenteriae Sd197 3796009 YP_404686.1 CDS ygfY NC_007606.1 2952973 2953239 D Code: S; COG: COG2938; hypothetical protein 2952973..2953239 Shigella dysenteriae Sd197 3796010 YP_404687.1 CDS SDY_3186 NC_007606.1 2953220 2953627 D hypothetical protein 2953220..2953627 Shigella dysenteriae Sd197 3796011 YP_404688.1 CDS fldB NC_007606.1 2953667 2954188 R ''An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic''; flavodoxin FldB complement(2953667..2954188) Shigella dysenteriae Sd197 3796012 YP_404689.1 CDS xerD NC_007606.1 2954300 2955196 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 2954300..2955196 Shigella dysenteriae Sd197 3796013 YP_404690.1 CDS dsbC NC_007606.1 2955221 2955931 D DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 2955221..2955931 Shigella dysenteriae Sd197 3796014 YP_404691.1 CDS recJ NC_007606.1 2955937 2957670 D 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 2955937..2957670 Shigella dysenteriae Sd197 3796015 YP_404692.1 CDS prfB NC_007606.1 2957978 2958859 D Code: J; COG: COG1186; peptide chain release factor 2 2957978..2958859 Shigella dysenteriae Sd197 3796016 YP_404693.1 CDS lysS NC_007606.1 2958869 2960386 D suppressor of ColE1 mutation in primer RNA; ''class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1''; lysyl-tRNA synthetase 2958869..2960386 Shigella dysenteriae Sd197 3796017 YP_404694.1 CDS SDY_3193 NC_007606.1 2960429 2960977 R catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase complement(2960429..2960977) Shigella dysenteriae Sd197 3796018 YP_404695.1 CDS insA NC_007606.1 2961191 2961466 D Code: L; COG: COG3677; insertion element IS1 protein InsA 2961191..2961466 Shigella dysenteriae Sd197 3796019 YP_404696.1 CDS SDY_3195 NC_007606.1 2961724 2962026 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 2961724..2962026 Shigella dysenteriae Sd197 3796020 YP_404697.1 CDS SDY_3196 NC_007606.1 2962167 2962934 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 2962167..2962934 Shigella dysenteriae Sd197 3796021 YP_009000818.1 CDS SDY_4743 NC_007606.1 2963433 2963705 D insertion element iso-IS1N protein InsA 2963433..2963705 Shigella dysenteriae Sd197 18263132 YP_404700.1 CDS SDY_3199 NC_007606.1 2963732 2964127 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2963732..2964127 Shigella dysenteriae Sd197 3798449 YP_404701.1 CDS ygiE NC_007606.1 2964216 2964989 R Code: P; COG: COG0428; zinc transporter ZupT complement(2964216..2964989) Shigella dysenteriae Sd197 3798450 YP_404702.1 CDS ygiC NC_007606.1 2965958 2967118 R Code: E; COG: COG0754; synthetase/amidase complement(2965958..2967118) Shigella dysenteriae Sd197 3798452 YP_404703.2 CDS ygiB NC_007606.1 2967124 2967795 R Code: S; COG: COG5463; hypothetical protein complement(2967124..2967795) Shigella dysenteriae Sd197 3798453 YP_404704.1 CDS ygiA NC_007606.1 2967683 2967943 R hypothetical protein complement(2967683..2967943) Shigella dysenteriae Sd197 3798454 YP_404705.2 CDS tolC NC_007606.1 2967943 2969424 R specific tolerance to colicin E1; segregation of daughter chromosomes; trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein complement(2967943..2969424) Shigella dysenteriae Sd197 3798455 YP_404706.1 CDS nudF NC_007606.1 2969629 2970258 D ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase 2969629..2970258 Shigella dysenteriae Sd197 3798456 YP_404707.1 CDS yqiB NC_007606.1 2970259 2970681 D Code: S; COG: COG3151; hypothetical protein 2970259..2970681 Shigella dysenteriae Sd197 3798457 YP_404708.1 CDS icc NC_007606.1 2970706 2971533 D Code: R; COG: COG1409; cyclic 3',5'-adenosine monophosphate phosphodiesterase 2970706..2971533 Shigella dysenteriae Sd197 3798458 YP_404709.1 CDS yqiA NC_007606.1 2971533 2972114 D Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase 2971533..2972114 Shigella dysenteriae Sd197 3798459 YP_404710.1 CDS parE NC_007606.1 2972143 2974035 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 2972143..2974035 Shigella dysenteriae Sd197 3798460 YP_404711.1 CDS ygiN NC_007606.1 2974083 2974397 R Code: S; COG: COG1359; hypothetical protein complement(2974083..2974397) Shigella dysenteriae Sd197 3798461 YP_404712.1 CDS mdaB NC_007606.1 2974428 2975009 R Code: R; COG: COG2249; modulator of drug activity B complement(2974428..2975009) Shigella dysenteriae Sd197 3798462 YP_404713.1 CDS qseC NC_007606.1 2975119 2976468 R Code: T; COG: COG0642; sensor protein QseC complement(2975119..2976468) Shigella dysenteriae Sd197 3798463 YP_404714.1 CDS ygiX NC_007606.1 2976465 2977124 R response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB complement(2976465..2977124) Shigella dysenteriae Sd197 3798464 YP_404715.1 CDS ygiW NC_007606.1 2977276 2977668 D Code: S; COG: COG3111; hypothetical protein 2977276..2977668 Shigella dysenteriae Sd197 3798465 YP_404716.1 CDS SDY_3216 NC_007606.1 2977721 2978203 D Code: L; COG: COG3449; hypothetical protein 2977721..2978203 Shigella dysenteriae Sd197 3798427 YP_404717.1 CDS SDY_3217 NC_007606.1 2978312 2979919 D YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; binding protein 2978312..2979919 Shigella dysenteriae Sd197 3798428 YP_404718.1 CDS parC NC_007606.1 2980057 2982315 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 2980057..2982315 Shigella dysenteriae Sd197 3798429 YP_404719.1 CDS plsC NC_007606.1 2982549 2983286 D Code: I; COG: COG0204; 1-acyl-sn-glycerol-3-phosphate acyltransferase 2982549..2983286 Shigella dysenteriae Sd197 3798430 YP_404720.1 CDS sufI NC_007606.1 2983361 2984773 D Code: Q; COG: COG2132; FtsI repressor 2983361..2984773 Shigella dysenteriae Sd197 3798431 YP_404721.1 CDS yqhH NC_007606.1 2987147 2987404 R Code: M; COG: COG4238; outer membrane lipoprotein complement(2987147..2987404) Shigella dysenteriae Sd197 3798433 YP_404722.1 CDS SDY_3223 NC_007606.1 2987453 2988052 R hypothetical protein complement(2987453..2988052) Shigella dysenteriae Sd197 3798434 YP_404723.1 CDS insB NC_007606.1 2988113 2988490 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2988113..2988490) Shigella dysenteriae Sd197 3798435 YP_404724.1 CDS insA NC_007606.1 2988535 2988810 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2988535..2988810) Shigella dysenteriae Sd197 3798436 YP_404725.1 CDS ribB NC_007606.1 2989128 2989781 R DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(2989128..2989781) Shigella dysenteriae Sd197 3798437 YP_404726.1 CDS SDY_3227 NC_007606.1 2990095 2990454 D Code: S; COG: COG2960; hypothetical protein 2990095..2990454 Shigella dysenteriae Sd197 3798438 YP_404727.1 CDS glgS NC_007606.1 2990489 2990689 R Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS complement(2990489..2990689) Shigella dysenteriae Sd197 3798439 YP_404728.1 CDS SDY_3229 NC_007606.1 2990706 2991101 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(2990706..2991101) Shigella dysenteriae Sd197 3798440 YP_009000819.1 CDS SDY_4744 NC_007606.1 2991128 2991400 R insertion element iso-IS1N protein InsA complement(2991128..2991400) Shigella dysenteriae Sd197 18263133 YP_404729.1 CDS insB NC_007606.1 2991621 2991998 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(2991621..2991998) Shigella dysenteriae Sd197 3798441 YP_404730.1 CDS insA NC_007606.1 2992043 2992318 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(2992043..2992318) Shigella dysenteriae Sd197 3798442 YP_009000820.1 CDS SDY_4745 NC_007606.1 2992529 2992801 D insertion element iso-IS1N protein InsA 2992529..2992801 Shigella dysenteriae Sd197 18263134 YP_404732.1 CDS SDY_3233 NC_007606.1 2992828 2993223 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2992828..2993223 Shigella dysenteriae Sd197 3798444 YP_404733.1 CDS SDY_3234 NC_007606.1 2993224 2994642 D Code: S; COG: COG2268; hypothetical protein 2993224..2994642 Shigella dysenteriae Sd197 3798445 YP_404734.1 CDS SDY_3235 NC_007606.1 2995436 2996869 R ''catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose''; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(2995436..2996869) Shigella dysenteriae Sd197 3798446 YP_404735.1 CDS glnE NC_007606.1 2996917 2999757 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(2996917..2999757) Shigella dysenteriae Sd197 3796748 YP_404736.1 CDS ygiF NC_007606.1 2999780 3001081 R Code: S; COG: COG3025; hypothetical protein complement(2999780..3001081) Shigella dysenteriae Sd197 3796749 YP_404737.1 CDS ygiM NC_007606.1 3001323 3001943 D Code: T; COG: COG3103; signal transduction protein 3001323..3001943 Shigella dysenteriae Sd197 3796750 YP_404738.1 CDS cca NC_007606.1 3002007 3003245 D ''catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases''; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3002007..3003245 Shigella dysenteriae Sd197 3796751 YP_404739.1 CDS folB NC_007606.1 3004319 3004690 R ''catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin''; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase complement(3004319..3004690) Shigella dysenteriae Sd197 3796753 YP_404740.1 CDS ygiH NC_007606.1 3004792 3005409 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 3004792..3005409 Shigella dysenteriae Sd197 3796754 YP_009000821.1 CDS SDY_4746 NC_007606.1 3006081 3006353 D insertion element iso-IS1N protein InsA 3006081..3006353 Shigella dysenteriae Sd197 18263135 YP_404741.1 CDS SDY_3244 NC_007606.1 3006380 3006775 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3006380..3006775 Shigella dysenteriae Sd197 3796756 YP_404742.1 CDS ygjE NC_007606.1 3008327 3009790 D Code: P; COG: COG0471; hypothetical protein 3008327..3009790 Shigella dysenteriae Sd197 3796759 YP_404743.1 CDS ygjD NC_007606.1 3009833 3010846 R ''in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity''; DNA-binding/iron metalloprotein/AP endonuclease complement(3009833..3010846) Shigella dysenteriae Sd197 3796760 YP_404744.1 CDS rpsU NC_007606.1 3011084 3011299 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3011084..3011299 Shigella dysenteriae Sd197 3796761 YP_404745.1 CDS dnaG NC_007606.1 3011411 3013156 D DNA biosynthesis; synthesizes RNA primers at the replication forks; DNA primase 3011411..3013156 Shigella dysenteriae Sd197 3796762 YP_404746.1 CDS rpoD NC_007606.1 3013351 3015192 D regulation of proteins induced at high temperatures; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3013351..3015192 Shigella dysenteriae Sd197 3796763 YP_404747.1 CDS ygjF NC_007606.1 3015271 3015777 R Code: L; COG: COG3663; G/U mismatch-specific DNA glycosylase complement(3015271..3015777) Shigella dysenteriae Sd197 3796764 YP_404748.1 CDS yqjH NC_007606.1 3016031 3016795 R Code: P; COG: COG2375; hypothetical protein complement(3016031..3016795) Shigella dysenteriae Sd197 3798369 YP_404749.1 CDS yqjI NC_007606.1 3017083 3017706 D Code: K; COG: COG1695; hypothetical protein 3017083..3017706 Shigella dysenteriae Sd197 3798370 YP_404750.1 CDS aer NC_007606.1 3017813 3019333 R Code: NT; COG: COG0840; aerotaxis sensor receptor, flavoprotein complement(3017813..3019333) Shigella dysenteriae Sd197 3798371 YP_404751.1 CDS ygjH NC_007606.1 3021172 3021504 R Code: R; COG: COG0073; hypothetical protein complement(3021172..3021504) Shigella dysenteriae Sd197 3798373 YP_404752.1 CDS ebgR NC_007606.1 3021723 3022706 D Code: K; COG: COG1609; DNA-binding transcriptional repressor EbgR 3021723..3022706 Shigella dysenteriae Sd197 3798374 YP_404753.1 CDS SDY_3261 NC_007606.1 3025539 3025934 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3025539..3025934) Shigella dysenteriae Sd197 3798376 YP_009000822.1 CDS SDY_4747 NC_007606.1 3025961 3026233 R insertion element iso-IS1N protein InsA complement(3025961..3026233) Shigella dysenteriae Sd197 18263136 YP_404754.1 CDS ygjK NC_007606.1 3027514 3029865 D glycosyl hydrolase 3027514..3029865 Shigella dysenteriae Sd197 3798378 YP_404755.1 CDS SDY_3264 NC_007606.1 3030250 3031689 D hypothetical protein 3030250..3031689 Shigella dysenteriae Sd197 3798379 YP_404756.1 CDS ygjL NC_007606.1 3031993 3034011 D Code: C; COG: COG1902; NADPH dehydrogenase 3031993..3034011 Shigella dysenteriae Sd197 3798380 YP_404757.1 CDS ygjM NC_007606.1 3034056 3034472 R Code: K; COG: COG5499; hypothetical protein complement(3034056..3034472) Shigella dysenteriae Sd197 3798381 YP_404758.1 CDS ygjO NC_007606.1 3034742 3035908 R Code: J; COG: COG2813; SAM-dependent 23S ribosomal RNA mG1835 methyltransferase complement(3034742..3035908) Shigella dysenteriae Sd197 3798382 YP_404759.1 CDS ygjP NC_007606.1 3035927 3036466 D Code: R; COG: COG1451; hypothetical protein 3035927..3036466 Shigella dysenteriae Sd197 3798383 YP_009000823.1 CDS SDY_4748 NC_007606.1 3036596 3036868 D insertion element iso-IS1N protein InsA 3036596..3036868 Shigella dysenteriae Sd197 18263137 YP_404761.1 CDS SDY_3270 NC_007606.1 3036895 3037290 D Code: L; COG: COG1662; insertion element IS1 protein InsB 3036895..3037290 Shigella dysenteriae Sd197 3798385 YP_404762.1 CDS ygjR NC_007606.1 3038071 3039075 D Code: R; COG: COG0673; hypothetical protein 3038071..3039075 Shigella dysenteriae Sd197 3798387 YP_404763.1 CDS ygjT NC_007606.1 3039358 3040323 D Code: P; COG: COG0861; transport protein 3039358..3040323 Shigella dysenteriae Sd197 3798670 YP_404764.1 CDS ygjU NC_007606.1 3040877 3042121 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3040877..3042121 Shigella dysenteriae Sd197 3798671 YP_404765.1 CDS ygjV NC_007606.1 3042126 3042665 R hypothetical protein complement(3042126..3042665) Shigella dysenteriae Sd197 3798672 YP_404766.1 CDS uxaA NC_007606.1 3042759 3044246 R Code: G; COG: COG2721; altronate hydrolase complement(3042759..3044246) Shigella dysenteriae Sd197 3798673 YP_404767.1 CDS exuT NC_007606.1 3045854 3047272 D Code: GEPR; COG: COG0477; hexuronates transporter 3045854..3047272 Shigella dysenteriae Sd197 3798675 YP_404768.1 CDS insB NC_007606.1 3047297 3047674 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(3047297..3047674) Shigella dysenteriae Sd197 3798676 YP_404769.1 CDS insA NC_007606.1 3047719 3047994 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3047719..3047994) Shigella dysenteriae Sd197 3798677 YP_404770.2 CDS exuR NC_007606.1 3048179 3048955 D ''regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.''; DNA-binding transcriptional repressor ExuR 3048179..3048955 Shigella dysenteriae Sd197 3798678 YP_404771.1 CDS yqjA NC_007606.1 3049300 3049962 D Code: S; COG: COG0586; hypothetical protein 3049300..3049962 Shigella dysenteriae Sd197 3798679 YP_404772.1 CDS yqjB NC_007606.1 3049966 3050349 D hypothetical protein 3049966..3050349 Shigella dysenteriae Sd197 3798680 YP_404773.1 CDS yqjC NC_007606.1 3050481 3050864 D hypothetical protein 3050481..3050864 Shigella dysenteriae Sd197 3798681 YP_404774.1 CDS yqjD NC_007606.1 3050902 3051207 D Code: S; COG: COG4575; hypothetical protein 3050902..3051207 Shigella dysenteriae Sd197 3798682 YP_404775.1 CDS yqjE NC_007606.1 3051210 3051614 D Code: S; COG: COG5393; hypothetical protein 3051210..3051614 Shigella dysenteriae Sd197 3798683 YP_404776.1 CDS SDY_3287 NC_007606.1 3051604 3051903 D hypothetical protein 3051604..3051903 Shigella dysenteriae Sd197 3798684 YP_404777.2 CDS SDY_3288 NC_007606.1 3052028 3052933 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(3052028..3052933) Shigella dysenteriae Sd197 3798685 YP_404778.1 CDS SDY_3289 NC_007606.1 3052891 3053256 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(3052891..3053256) Shigella dysenteriae Sd197 3798686 YP_404779.2 CDS yqjF NC_007606.1 3053426 3053818 D Code: S; COG: COG2259; hypothetical protein 3053426..3053818 Shigella dysenteriae Sd197 3798687 YP_404780.1 CDS yqjG NC_007606.1 3053888 3054874 D Code: O; COG: COG0435; transferase 3053888..3054874 Shigella dysenteriae Sd197 3798688 YP_404781.1 CDS yhaH NC_007606.1 3055157 3055522 D Code: S; COG: COG3152; cytochrome 3055157..3055522 Shigella dysenteriae Sd197 3796363 YP_404782.1 CDS SDY_3293 NC_007606.1 3055712 3056107 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(3055712..3056107) Shigella dysenteriae Sd197 3796364 YP_009000824.1 CDS SDY_4749 NC_007606.1 3056134 3056406 R insertion element iso-IS1N protein InsA complement(3056134..3056406) Shigella dysenteriae Sd197 18263138 YP_404783.1 CDS insA NC_007606.1 3056700 3056975 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3056700..3056975 Shigella dysenteriae Sd197 3796366 YP_404784.1 CDS insB NC_007606.1 3057020 3057397 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3057020..3057397 Shigella dysenteriae Sd197 3796367 YP_404785.1 CDS yhaJ NC_007606.1 3057722 3058627 R Code: K; COG: COG0583; LysR family transcriptional regulator complement(3057722..3058627) Shigella dysenteriae Sd197 3796368 YP_404786.1 CDS yhaK NC_007606.1 3058732 3059433 D Code: R; COG: COG1741; hypothetical protein 3058732..3059433 Shigella dysenteriae Sd197 3796369 YP_404787.1 CDS yhaL NC_007606.1 3059453 3059620 D hypothetical protein 3059453..3059620 Shigella dysenteriae Sd197 3796370 YP_404788.1 CDS yhaNM NC_007606.1 3059754 3061064 R Code: S; COG: COG3681; hypothetical protein complement(3059754..3061064) Shigella dysenteriae Sd197 3796371 YP_404789.1 CDS yhaO NC_007606.1 3061092 3062423 R Code: E; COG: COG0814; transport system permease complement(3061092..3062423) Shigella dysenteriae Sd197 3796372 YP_404790.1 CDS insB NC_007606.1 3062613 3062990 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(3062613..3062990) Shigella dysenteriae Sd197 3796373 YP_404791.1 CDS insA NC_007606.1 3063035 3063310 R Code: L; COG: COG3677; insertion element iso-IS1d protein InsA complement(3063035..3063310) Shigella dysenteriae Sd197 3796374 YP_404792.2 CDS yhaP NC_007606.1 3063475 3064839 R Code: E; COG: COG1760; L-serine dehydratase complement(3063475..3064839) Shigella dysenteriae Sd197 3796375 YP_404793.1 CDS tdcE NC_007606.1 3065315 3067609 R Code: C; COG: COG1882; formate acetyltransferase 3 complement(3065315..3067609) Shigella dysenteriae Sd197 3796377 YP_404794.1 CDS tdcD NC_007606.1 3067643 3068863 R catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase complement(3067643..3068863) Shigella dysenteriae Sd197 3796378 YP_404795.1 CDS tdcC NC_007606.1 3068877 3070208 R involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC complement(3068877..3070208) Shigella dysenteriae Sd197 3796379 YP_404796.1 CDS tdcB NC_007606.1 3070230 3071219 R catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase complement(3070230..3071219) Shigella dysenteriae Sd197 3796380 YP_404797.1 CDS tdcA NC_007606.1 3071318 3072256 R regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA complement(3071318..3072256) Shigella dysenteriae Sd197 3796381 YP_404798.1 CDS tdcR NC_007606.1 3072445 3072789 D participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3072445..3072789 Shigella dysenteriae Sd197 3796382 YP_009000825.1 CDS SDY_4750 NC_007606.1 3073132 3073404 D insertion element iso-IS1N protein InsA 3073132..3073404 Shigella dysenteriae Sd197 18263139 YP_404801.1 CDS insB NC_007606.1 3074215 3074592 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(3074215..3074592) Shigella dysenteriae Sd197 3798390 YP_404802.1 CDS insA NC_007606.1 3074637 3074912 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3074637..3074912) Shigella dysenteriae Sd197 3798391 YP_404803.1 CDS SDY_3317 NC_007606.1 3075357 3075752 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3075357..3075752) Shigella dysenteriae Sd197 3798393 YP_009000826.1 CDS SDY_4752 NC_007606.1 3075779 3076051 R insertion element iso-IS1N protein InsA complement(3075779..3076051) Shigella dysenteriae Sd197 18263140 YP_404804.2 CDS yhaD NC_007606.1 3077008 3078153 R Code: G; COG: COG1929; glycerate kinase complement(3077008..3078153) Shigella dysenteriae Sd197 3798394 YP_404805.2 CDS garR NC_007606.1 3078250 3079140 R catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase complement(3078250..3079140) Shigella dysenteriae Sd197 3798395 YP_404806.1 CDS yhaF NC_007606.1 3079170 3079940 R cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase complement(3079170..3079940) Shigella dysenteriae Sd197 3798396 YP_404807.1 CDS insA NC_007606.1 3081323 3081598 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3081323..3081598 Shigella dysenteriae Sd197 3798398 YP_404808.1 CDS insB NC_007606.1 3081643 3082020 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3081643..3082020 Shigella dysenteriae Sd197 3798399 YP_404809.1 CDS yraK NC_007606.1 3082053 3083144 D Code: NU; COG: COG3539; fimbrial protein 3082053..3083144 Shigella dysenteriae Sd197 3798400 YP_404810.1 CDS yraL NC_007606.1 3083187 3084047 R Code: R; COG: COG0313; hypothetical protein complement(3083187..3084047) Shigella dysenteriae Sd197 3798401 YP_404811.1 CDS yraM NC_007606.1 3084112 3086148 D Code: R; COG: COG3107; glycosylase 3084112..3086148 Shigella dysenteriae Sd197 3798402 YP_404812.1 CDS yraN NC_007606.1 3086106 3086501 D Code: L; COG: COG0792; hypothetical protein 3086106..3086501 Shigella dysenteriae Sd197 3798403 YP_404813.1 CDS yraO NC_007606.1 3086521 3087111 D Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; chromosome replication initiator DnaA 3086521..3087111 Shigella dysenteriae Sd197 3798404 YP_404814.1 CDS yraP NC_007606.1 3087121 3087696 D Code: R; COG: COG2823; hypothetical protein 3087121..3087696 Shigella dysenteriae Sd197 3798405 YP_404815.1 CDS yraR NC_007606.1 3088923 3089603 R Code: MG; COG: COG0702; hypothetical protein complement(3088923..3089603) Shigella dysenteriae Sd197 3798407 YP_404816.1 CDS yhbO NC_007606.1 3089644 3090204 D Code: R; COG: COG0693; hypothetical protein 3089644..3090204 Shigella dysenteriae Sd197 3798408 YP_404817.1 CDS yhbP NC_007606.1 3090184 3090627 R Code: S; COG: COG3787; hypothetical protein complement(3090184..3090627) Shigella dysenteriae Sd197 3798409 YP_404818.1 CDS yhbQ NC_007606.1 3090678 3090980 D Code: L; COG: COG2827; GIY-YIG nuclease superfamily protein 3090678..3090980 Shigella dysenteriae Sd197 3798410 YP_404819.1 CDS yhbS NC_007606.1 3090967 3091470 R Code: R; COG: COG3153; hypothetical protein complement(3090967..3091470) Shigella dysenteriae Sd197 3798411 YP_404820.1 CDS yhbT NC_007606.1 3091464 3091988 R Code: I; COG: COG3154; hypothetical protein complement(3091464..3091988) Shigella dysenteriae Sd197 3798412 YP_404821.1 CDS yhbU NC_007606.1 3092197 3093192 D Code: O; COG: COG0826; collagenase 3092197..3093192 Shigella dysenteriae Sd197 3798413 YP_404822.1 CDS yhbV NC_007606.1 3093183 3094079 D Code: O; COG: COG0826; hypothetical protein 3093183..3094079 Shigella dysenteriae Sd197 3798414 YP_404823.1 CDS yhbW NC_007606.1 3094160 3095167 D Code: C; COG: COG2141; hypothetical protein 3094160..3095167 Shigella dysenteriae Sd197 3798415 YP_404824.1 CDS mtr NC_007606.1 3095284 3096528 R tryptophan transporter of high affinity; tryptophan permease complement(3095284..3096528) Shigella dysenteriae Sd197 3798416 YP_404825.2 CDS deaD NC_007606.1 3096682 3098571 R participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD complement(3096682..3098571) Shigella dysenteriae Sd197 3798417 YP_404826.1 CDS yhbM NC_007606.1 3098751 3099635 R lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI complement(3098751..3099635) Shigella dysenteriae Sd197 3798418 YP_404827.1 CDS pnp NC_007606.1 3099744 3101948 R cytidylate kinase activity; Code: J; COG: COG1185; polynucleotide phosphorylase complement(3099744..3101948) Shigella dysenteriae Sd197 3798419 YP_404828.1 CDS rpsO NC_007606.1 3102126 3102395 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(3102126..3102395) Shigella dysenteriae Sd197 3798420 YP_404829.1 CDS truB NC_007606.1 3102544 3103488 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(3102544..3103488) Shigella dysenteriae Sd197 3798421 YP_404830.1 CDS rbfA NC_007606.1 3103488 3103889 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(3103488..3103889) Shigella dysenteriae Sd197 3798422 YP_404831.1 CDS infB NC_007606.1 3104053 3106725 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(3104053..3106725) Shigella dysenteriae Sd197 3798423 YP_404832.1 CDS nusA NC_007606.1 3106750 3108237 R L factor; ''modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination''; transcription elongation factor NusA complement(3106750..3108237) Shigella dysenteriae Sd197 3798424 YP_404833.2 CDS yhbC NC_007606.1 3108265 3108717 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(3108265..3108717) Shigella dysenteriae Sd197 3798425 YP_404834.1 CDS argG NC_007606.1 3109348 3110691 D catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3109348..3110691 Shigella dysenteriae Sd197 3798766 YP_404835.2 CDS yhbX NC_007606.1 3110699 3112306 R Code: R; COG: COG2194; alkaline phosphatase I complement(3110699..3112306) Shigella dysenteriae Sd197 3798767 YP_009000827.1 CDS SDY_4754 NC_007606.1 3112800 3113072 R insertion element iso-IS1N protein InsA complement(3112800..3113072) Shigella dysenteriae Sd197 18263141 YP_404838.1 CDS secG NC_007606.1 3113578 3113910 R Code: U; COG: COG1314; preprotein translocase subunit SecG complement(3113578..3113910) Shigella dysenteriae Sd197 3798771 YP_404839.1 CDS glmM NC_007606.1 3114138 3115475 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(3114138..3115475) Shigella dysenteriae Sd197 3798772 YP_404840.2 CDS folP NC_007606.1 3115468 3116316 R ''catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate''; dihydropteroate synthase complement(3115468..3116316) Shigella dysenteriae Sd197 3798773 YP_404841.1 CDS hflB NC_007606.1 3116406 3118340 R degrades sigma32, integral membrane peptidase, cell division protein; inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease complement(3116406..3118340) Shigella dysenteriae Sd197 3798774 YP_404842.1 CDS rrmJ NC_007606.1 3118440 3119069 R Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase complement(3118440..3119069) Shigella dysenteriae Sd197 3798775 YP_404843.1 CDS yhbY NC_007606.1 3119195 3119488 D RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3119195..3119488 Shigella dysenteriae Sd197 3798776 YP_404844.2 CDS greA NC_007606.1 3119645 3120121 R cleaves 3' nucleotide of paused mRNA; ''necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus''; transcription elongation factor GreA complement(3119645..3120121) Shigella dysenteriae Sd197 3798777 YP_404845.1 CDS dacB NC_007606.1 3120368 3121801 D penicillin-binding protein 4; ''penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains''; D-alanyl-D-alanine carboxypeptidase 3120368..3121801 Shigella dysenteriae Sd197 3798778 YP_404846.1 CDS obgE NC_007606.1 3121841 3123013 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(3121841..3123013) Shigella dysenteriae Sd197 3798779 YP_404847.1 CDS yhbE NC_007606.1 3123029 3123994 R Code: GER; COG: COG0697; hypothetical protein complement(3123029..3123994) Shigella dysenteriae Sd197 3798780 YP_404848.1 CDS rpmA NC_007606.1 3124121 3124378 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(3124121..3124378) Shigella dysenteriae Sd197 3798781 YP_404849.1 CDS rplU NC_007606.1 3124399 3124710 R Code: J; COG: COG0261; 50S ribosomal protein L21 complement(3124399..3124710) Shigella dysenteriae Sd197 3798782 YP_404850.1 CDS ispB NC_007606.1 3124968 3125939 D Code: H; COG: COG0142; octaprenyl diphosphate synthase 3124968..3125939 Shigella dysenteriae Sd197 3796558 YP_404851.1 CDS nlp NC_007606.1 3126167 3126445 D activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3126167..3126445 Shigella dysenteriae Sd197 3796559 YP_404852.1 CDS murA NC_007606.1 3126493 3127752 R first step in murein biosynthesis; adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(3126493..3127752) Shigella dysenteriae Sd197 3796560 YP_404853.1 CDS yrbA NC_007606.1 3127807 3128076 R Code: K; COG: COG5007; hypothetical protein complement(3127807..3128076) Shigella dysenteriae Sd197 3796561 YP_404854.2 CDS yrbB NC_007606.1 3128221 3128514 R Code: R; COG: COG3113; hypothetical protein complement(3128221..3128514) Shigella dysenteriae Sd197 3796562 YP_404855.1 CDS yrbC NC_007606.1 3128514 3129149 R Code: Q; COG: COG2854; hypothetical protein complement(3128514..3129149) Shigella dysenteriae Sd197 3796563 YP_404856.1 CDS yrbD NC_007606.1 3129168 3129719 R Code: Q; COG: COG1463; hypothetical protein complement(3129168..3129719) Shigella dysenteriae Sd197 3796564 YP_404857.1 CDS yrbE NC_007606.1 3129724 3130506 R Code: Q; COG: COG0767; hypothetical protein complement(3129724..3130506) Shigella dysenteriae Sd197 3796565 YP_404858.1 CDS yrbF NC_007606.1 3130514 3131323 R ATP-binding subunit of a ABC toluene efflux transporter; ABC transporter ATP-binding protein YrbF complement(3130514..3131323) Shigella dysenteriae Sd197 3796566 YP_404859.1 CDS yrbG NC_007606.1 3131536 3132501 D YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 3131536..3132501 Shigella dysenteriae Sd197 3796567 YP_404860.1 CDS yrbH NC_007606.1 3132515 3133501 D Code: M; COG: COG0794; D-arabinose 5-phosphate isomerase 3132515..3133501 Shigella dysenteriae Sd197 3796568 YP_404861.1 CDS yrbI NC_007606.1 3133522 3134088 D forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3133522..3134088 Shigella dysenteriae Sd197 3796569 YP_404862.1 CDS yrbK NC_007606.1 3134085 3134660 D Code: S; COG: COG3117; hypothetical protein 3134085..3134660 Shigella dysenteriae Sd197 3796570 YP_404863.1 CDS yhbN NC_007606.1 3134629 3135186 D ''LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system''; lipopolysaccharide transport periplasmic protein LptA 3134629..3135186 Shigella dysenteriae Sd197 3796571 YP_404864.1 CDS yhbG NC_007606.1 3135193 3135918 D Code: R; COG: COG1137; ABC transporter ATP-binding protein YhbG 3135193..3135918 Shigella dysenteriae Sd197 3796572 YP_404865.1 CDS rpoN NC_007606.1 3135966 3137399 D nitrogen and fermentation regulation; ''sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen''; RNA polymerase factor sigma-54 3135966..3137399 Shigella dysenteriae Sd197 3796573 YP_404866.1 CDS yhbH NC_007606.1 3137422 3137709 D YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 3137422..3137709 Shigella dysenteriae Sd197 3796574 YP_404867.1 CDS ptsN NC_007606.1 3137827 3138318 D regulates N metabolism; Code: GT; COG: COG1762; PTS system transporter subunit IIA 3137827..3138318 Shigella dysenteriae Sd197 3796575 YP_404868.1 CDS yhbJ NC_007606.1 3138364 3139218 D Code: R; COG: COG1660; hypothetical protein 3138364..3139218 Shigella dysenteriae Sd197 3796576 YP_404869.1 CDS ptsO NC_007606.1 3139215 3139487 D nitrogen related, exchanges phosphate with Enzyme I, Hpr; Code: G; COG: COG1925; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3139215..3139487 Shigella dysenteriae Sd197 3796577 YP_404870.1 CDS yrbL NC_007606.1 3139701 3140333 D hypothetical protein 3139701..3140333 Shigella dysenteriae Sd197 3796462 YP_404871.1 CDS mtgA NC_007606.1 3140330 3141058 R glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase complement(3140330..3141058) Shigella dysenteriae Sd197 3796463 YP_404872.1 CDS yhbL NC_007606.1 3141055 3141717 R SCRP-27A; Code: Q; COG: COG3155; isoprenoid biosynthesis protein with amidotransferase-like domain complement(3141055..3141717) Shigella dysenteriae Sd197 3796464 YP_404873.1 CDS arcB NC_007606.1 3141938 3144274 R histidine protein kinase/phosphatase, sensor for arcA; sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB complement(3141938..3144274) Shigella dysenteriae Sd197 3796465 YP_404874.1 CDS yhcC NC_007606.1 3144370 3145299 R Code: R; COG: COG1242; hypothetical protein complement(3144370..3145299) Shigella dysenteriae Sd197 3796466 YP_404875.1 CDS gltB NC_007606.1 3145973 3150433 D catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3145973..3150433 Shigella dysenteriae Sd197 3796467 YP_404876.1 CDS gltD NC_007606.1 3150446 3151864 D ''glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate''; glutamate synthase subunit beta 3150446..3151864 Shigella dysenteriae Sd197 3796468 YP_404877.1 CDS yhcG NC_007606.1 3152048 3153175 D Code: S; COG: COG4804; hypothetical protein 3152048..3153175 Shigella dysenteriae Sd197 3796469 YP_404878.1 CDS yhcH NC_007606.1 3153235 3153699 R Code: G; COG: COG2731; hypothetical protein complement(3153235..3153699) Shigella dysenteriae Sd197 3796470 YP_404879.2 CDS yhcI NC_007606.1 3153696 3154571 R catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase complement(3153696..3154571) Shigella dysenteriae Sd197 3796471 YP_404880.1 CDS yhcJ NC_007606.1 3154568 3155257 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(3154568..3155257) Shigella dysenteriae Sd197 3796472 YP_404881.2 CDS nanT NC_007606.1 3155305 3156795 R Code: GEPR; COG: COG0477; sialic acid transporter complement(3155305..3156795) Shigella dysenteriae Sd197 3796473 YP_404882.1 CDS nanA NC_007606.1 3156904 3157797 R aldolase; catabolism of sialic acid; not K12?; catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase complement(3156904..3157797) Shigella dysenteriae Sd197 3796474 YP_404883.1 CDS yhcK NC_007606.1 3157991 3158782 R Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR complement(3157991..3158782) Shigella dysenteriae Sd197 3796475 YP_404885.1 CDS sspB NC_007606.1 3160299 3160796 R Code: R; COG: COG2969; ClpXP protease specificity-enhancing factor complement(3160299..3160796) Shigella dysenteriae Sd197 3796478 YP_404886.1 CDS sspA NC_007606.1 3160802 3161440 R regulator of transcription; transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A complement(3160802..3161440) Shigella dysenteriae Sd197 3796479 YP_404887.1 CDS rpsI NC_007606.1 3161834 3162226 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(3161834..3162226) Shigella dysenteriae Sd197 3796480 YP_404888.1 CDS rplM NC_007606.1 3162242 3162670 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(3162242..3162670) Shigella dysenteriae Sd197 3797572 YP_404889.1 CDS yhcM NC_007606.1 3162889 3164016 R Code: R; COG: COG1485; hypothetical protein complement(3162889..3164016) Shigella dysenteriae Sd197 3797573 YP_404890.1 CDS yhcB NC_007606.1 3164204 3164608 D Code: S; COG: COG3105; cytochrome d ubiquinol oxidase subunit III 3164204..3164608 Shigella dysenteriae Sd197 3797574 YP_404891.1 CDS degQ NC_007606.1 3164762 3166129 D Code: O; COG: COG0265; serine endoprotease 3164762..3166129 Shigella dysenteriae Sd197 3797575 YP_404892.1 CDS degS NC_007606.1 3166219 3167286 D Code: O; COG: COG0265; serine endoprotease 3166219..3167286 Shigella dysenteriae Sd197 3797576 YP_404893.1 CDS mdh NC_007606.1 3167349 3168287 R oxidizes malate to oxaloacetate; malate dehydrogenase complement(3167349..3168287) Shigella dysenteriae Sd197 3797577 YP_404894.1 CDS argR NC_007606.1 3168722 3169192 D cer-mediated site-specific recombination; regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 3168722..3169192 Shigella dysenteriae Sd197 3797578 YP_404895.1 CDS yhcN NC_007606.1 3169557 3169820 D hypothetical protein 3169557..3169820 Shigella dysenteriae Sd197 3797579 YP_404896.1 CDS yhcO NC_007606.1 3169876 3170148 R Code: K; COG: COG2732; hypothetical protein complement(3169876..3170148) Shigella dysenteriae Sd197 3797580 YP_404897.1 CDS yhcP NC_007606.1 3170240 3172207 R with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB complement(3170240..3172207) Shigella dysenteriae Sd197 3797581 YP_404898.1 CDS yhcQ NC_007606.1 3172213 3173145 R ''with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate''; p-hydroxybenzoic acid efflux subunit AaeA complement(3172213..3173145) Shigella dysenteriae Sd197 3797582 YP_404899.2 CDS yhcR NC_007606.1 3173153 3173356 R membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein complement(3173153..3173356) Shigella dysenteriae Sd197 3797583 YP_404900.1 CDS qseA NC_007606.1 3173539 3174468 D Code: K; COG: COG0583; DNA-binding transcriptional regulator 3173539..3174468 Shigella dysenteriae Sd197 3797584 YP_404901.1 CDS tldD NC_007606.1 3174596 3176041 R ''responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA''; protease TldD complement(3174596..3176041) Shigella dysenteriae Sd197 3797585 YP_404902.1 CDS yhdRP NC_007606.1 3176197 3179997 R Code: S; COG: COG3164; hypothetical protein complement(3176197..3179997) Shigella dysenteriae Sd197 3797586 YP_404903.2 CDS cafA NC_007606.1 3180065 3181534 R involved in the processing of the 5'end of 16S rRNA; ribonuclease G complement(3180065..3181534) Shigella dysenteriae Sd197 3797587 YP_404904.1 CDS yhdE NC_007606.1 3181524 3182117 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(3181524..3182117) Shigella dysenteriae Sd197 3797588 YP_404905.1 CDS mreD NC_007606.1 3182126 3182614 R part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD complement(3182126..3182614) Shigella dysenteriae Sd197 3797589 YP_404906.1 CDS mreC NC_007606.1 3182614 3183717 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(3182614..3183717) Shigella dysenteriae Sd197 3797590 YP_404907.2 CDS mreB NC_007606.1 3183783 3184826 R regulator of ftsI; septation function; functions in MreBCD complex in some organisms; rod shape-determining protein MreB complement(3183783..3184826) Shigella dysenteriae Sd197 3797591 YP_404908.1 CDS yhdA NC_007606.1 3185131 3187071 R regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD complement(3185131..3187071) Shigella dysenteriae Sd197 3797729 YP_404909.1 CDS yhdH NC_007606.1 3187223 3188197 D Code: CR; COG: COG0604; dehydrogenase 3187223..3188197 Shigella dysenteriae Sd197 3797730 YP_404911.1 CDS SDY_3429 NC_007606.1 3188339 3189064 D hypothetical protein 3188339..3189064 Shigella dysenteriae Sd197 3797731 YP_404913.1 CDS accB NC_007606.1 3189930 3190400 D carrier of biotin; ''composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism''; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3189930..3190400 Shigella dysenteriae Sd197 3797734 YP_404914.1 CDS accC NC_007606.1 3190411 3191760 D ''an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism''; acetyl-CoA carboxylase biotin carboxylase subunit 3190411..3191760 Shigella dysenteriae Sd197 3797735 YP_404915.1 CDS yhdT NC_007606.1 3191869 3192111 D Code: S; COG: COG3924; hypothetical protein 3191869..3192111 Shigella dysenteriae Sd197 3797736 YP_404916.2 CDS panF NC_007606.1 3192101 3193552 D mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3192101..3193552 Shigella dysenteriae Sd197 3797737 YP_404917.1 CDS prmA NC_007606.1 3193564 3194445 D methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 3193564..3194445 Shigella dysenteriae Sd197 3797738 YP_404918.1 CDS yhdG NC_007606.1 3194774 3195739 D Code: J; COG: COG0042; tRNA-dihydrouridine synthase B 3194774..3195739 Shigella dysenteriae Sd197 3797739 YP_404919.1 CDS fis NC_007606.1 3195765 3196061 D DNA-binding protein; a trans activator for transcription; Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; Fis family transcriptional regulator 3195765..3196061 Shigella dysenteriae Sd197 3797740 YP_404920.1 CDS insA NC_007606.1 3196778 3197053 D Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 3196778..3197053 Shigella dysenteriae Sd197 3797742 YP_404921.1 CDS insB NC_007606.1 3197098 3197475 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3197098..3197475 Shigella dysenteriae Sd197 3797743 YP_404923.1 CDS insA NC_007606.1 3201152 3201427 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3201152..3201427) Shigella dysenteriae Sd197 3797746 YP_404924.1 CDS yhdW NC_007606.1 3201757 3202674 D Code: ET; COG: COG0834; periplasmic binding transport protein 3201757..3202674 Shigella dysenteriae Sd197 3797747 YP_404925.1 CDS yhdY NC_007606.1 3203930 3205036 D Code: E; COG: COG0765; transport system permease 3203930..3205036 Shigella dysenteriae Sd197 3798658 YP_404926.2 CDS yrdA NC_007606.1 3211672 3212226 D Code: R; COG: COG0663; transferase 3211672..3212226 Shigella dysenteriae Sd197 3798667 YP_404927.1 CDS yrdB NC_007606.1 3212202 3212459 R hypothetical protein complement(3212202..3212459) Shigella dysenteriae Sd197 3798668 YP_404928.1 CDS aroE NC_007606.1 3212456 3213274 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(3212456..3213274) Shigella dysenteriae Sd197 3798669 YP_404929.1 CDS yrdC NC_007606.1 3213279 3213851 R RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor complement(3213279..3213851) Shigella dysenteriae Sd197 3798709 YP_404930.1 CDS yrdD NC_007606.1 3213856 3214398 R Code: L; COG: COG0551; DNA topoisomerase complement(3213856..3214398) Shigella dysenteriae Sd197 3798710 YP_404931.1 CDS smg NC_007606.1 3214427 3214900 R Code: S; COG: COG2922; hypothetical protein complement(3214427..3214900) Shigella dysenteriae Sd197 3798711 YP_404932.1 CDS smf NC_007606.1 3214872 3215996 R involved in DNA uptake; Code: LU; COG: COG0758; DNA protecting protein DprA complement(3214872..3215996) Shigella dysenteriae Sd197 3798712 YP_404933.1 CDS def NC_007606.1 3216126 3216635 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3216126..3216635 Shigella dysenteriae Sd197 3798713 YP_404934.1 CDS fmt NC_007606.1 3216650 3217597 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3216650..3217597 Shigella dysenteriae Sd197 3798714 YP_404935.1 CDS sun NC_007606.1 3217643 3218932 D catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase GidB 3217643..3218932 Shigella dysenteriae Sd197 3798715 YP_404936.1 CDS trkA NC_007606.1 3218954 3220330 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 3218954..3220330 Shigella dysenteriae Sd197 3798716 YP_404937.1 CDS zntR NC_007606.1 3221143 3221568 R mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator complement(3221143..3221568) Shigella dysenteriae Sd197 3798718 YP_404938.1 CDS yhdN NC_007606.1 3221579 3221947 R hypothetical protein complement(3221579..3221947) Shigella dysenteriae Sd197 3798719 YP_404939.1 CDS rplQ NC_007606.1 3222054 3222437 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(3222054..3222437) Shigella dysenteriae Sd197 3798720 YP_404940.1 CDS rpoA NC_007606.1 3222478 3223467 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(3222478..3223467) Shigella dysenteriae Sd197 3798721 YP_404941.1 CDS rpsD NC_007606.1 3223493 3224113 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(3223493..3224113) Shigella dysenteriae Sd197 3798722 YP_404942.1 CDS rpsK NC_007606.1 3224147 3224536 R ''located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3''; 30S ribosomal protein S11 complement(3224147..3224536) Shigella dysenteriae Sd197 3798723 YP_404943.1 CDS rpsM NC_007606.1 3224553 3224909 R ''located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA''; 30S ribosomal protein S13 complement(3224553..3224909) Shigella dysenteriae Sd197 3798724 YP_404944.1 CDS rpmJ NC_007606.1 3225056 3225172 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(3225056..3225172) Shigella dysenteriae Sd197 3798725 YP_404945.1 CDS secY NC_007606.1 3225204 3226535 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(3225204..3226535) Shigella dysenteriae Sd197 3798726 YP_404946.1 CDS rplO NC_007606.1 3226543 3226977 R late assembly protein; 50S ribosomal protein L15 complement(3226543..3226977) Shigella dysenteriae Sd197 3798727 YP_404947.1 CDS rpmD NC_007606.1 3226981 3227160 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(3226981..3227160) Shigella dysenteriae Sd197 3796670 YP_404948.1 CDS rpsE NC_007606.1 3227164 3227667 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(3227164..3227667) Shigella dysenteriae Sd197 3796671 YP_404949.1 CDS rplR NC_007606.1 3227682 3228035 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(3227682..3228035) Shigella dysenteriae Sd197 3796672 YP_404950.1 CDS rplF NC_007606.1 3228045 3228578 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(3228045..3228578) Shigella dysenteriae Sd197 3796673 YP_404951.1 CDS rpsH NC_007606.1 3228591 3228983 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(3228591..3228983) Shigella dysenteriae Sd197 3796674 YP_404952.1 CDS rpsN NC_007606.1 3229017 3229322 R ''located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif''; 30S ribosomal protein S14 complement(3229017..3229322) Shigella dysenteriae Sd197 3796675 YP_404953.1 CDS rplE NC_007606.1 3229337 3229876 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(3229337..3229876) Shigella dysenteriae Sd197 3796676 YP_404954.1 CDS rplX NC_007606.1 3229891 3230205 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(3229891..3230205) Shigella dysenteriae Sd197 3796677 YP_404955.1 CDS rplN NC_007606.1 3230216 3230587 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(3230216..3230587) Shigella dysenteriae Sd197 3796678 YP_404956.1 CDS rpsQ NC_007606.1 3230752 3231006 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(3230752..3231006) Shigella dysenteriae Sd197 3796679 YP_404957.1 CDS rpmC NC_007606.1 3231006 3231197 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(3231006..3231197) Shigella dysenteriae Sd197 3796680 YP_404958.1 CDS rplP NC_007606.1 3231197 3231607 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(3231197..3231607) Shigella dysenteriae Sd197 3796681 YP_404959.1 CDS rpsC NC_007606.1 3231620 3232321 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(3231620..3232321) Shigella dysenteriae Sd197 3796682 YP_404960.1 CDS rplV NC_007606.1 3232339 3232671 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(3232339..3232671) Shigella dysenteriae Sd197 3796683 YP_404961.1 CDS rpsS NC_007606.1 3232686 3232964 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(3232686..3232964) Shigella dysenteriae Sd197 3796684 YP_404962.1 CDS rplB NC_007606.1 3232981 3233802 R ''one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation''; 50S ribosomal protein L2 complement(3232981..3233802) Shigella dysenteriae Sd197 3796685 YP_404963.1 CDS rplW NC_007606.1 3233820 3234122 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(3233820..3234122) Shigella dysenteriae Sd197 3796686 YP_404964.1 CDS rplD NC_007606.1 3234119 3234724 R regulates expression of S10 operon; L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(3234119..3234724) Shigella dysenteriae Sd197 3796687 YP_404965.1 CDS rplC NC_007606.1 3234735 3235364 R ''binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin''; 50S ribosomal protein L3 complement(3234735..3235364) Shigella dysenteriae Sd197 3796688 YP_404966.1 CDS rpsJ NC_007606.1 3235397 3235708 R ''NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex''; 30S ribosomal protein S10 complement(3235397..3235708) Shigella dysenteriae Sd197 3796689 YP_404967.1 CDS bfr NC_007606.1 3236551 3237027 R an iron storage homoprotein; iron storage protein; bacterioferritin complement(3236551..3237027) Shigella dysenteriae Sd197 3797787 YP_404968.1 CDS SDY_3499 NC_007606.1 3237100 3237294 R Code: P; COG: COG2906; bacterioferritin-associated ferredoxin complement(3237100..3237294) Shigella dysenteriae Sd197 3797788 YP_404969.1 CDS tufA NC_007606.1 3237477 3238661 R duplicate of tufB; ''EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu''; elongation factor Tu complement(3237477..3238661) Shigella dysenteriae Sd197 3797789 YP_404970.1 CDS fusA NC_007606.1 3238732 3240846 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(3238732..3240846) Shigella dysenteriae Sd197 3797790 YP_404971.1 CDS rpsG NC_007606.1 3240943 3241413 R initiates assembly; binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(3240943..3241413) Shigella dysenteriae Sd197 3797791 YP_404972.1 CDS rpsL NC_007606.1 3241510 3241884 R ''interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance''; 30S ribosomal protein S12 complement(3241510..3241884) Shigella dysenteriae Sd197 3797792 YP_404973.1 CDS yheL NC_007606.1 3242010 3242297 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB complement(3242010..3242297) Shigella dysenteriae Sd197 3797793 YP_404974.1 CDS yheM NC_007606.1 3242305 3242664 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC complement(3242305..3242664) Shigella dysenteriae Sd197 3797794 YP_404975.1 CDS yheN NC_007606.1 3242664 3243050 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD complement(3242664..3243050) Shigella dysenteriae Sd197 3797795 YP_404976.1 CDS yheO NC_007606.1 3243050 3243784 R Code: S; COG: COG2964; hypothetical protein complement(3243050..3243784) Shigella dysenteriae Sd197 3797796 YP_404977.1 CDS fkpA NC_007606.1 3243939 3244733 R rotamase; FKBP-type peptidylprolyl isomerase complement(3243939..3244733) Shigella dysenteriae Sd197 3797797 YP_404978.1 CDS slyX NC_007606.1 3244954 3245172 D Code: S; COG: COG2900; hypothetical protein 3244954..3245172 Shigella dysenteriae Sd197 3797798 YP_404979.1 CDS slyD NC_007606.1 3245221 3245799 R rotamase; FKBP-type peptidylprolyl isomerase complement(3245221..3245799) Shigella dysenteriae Sd197 3797799 YP_404980.1 CDS SDY_3511 NC_007606.1 3245894 3246094 R Code: R; COG: COG3529; hypothetical protein complement(3245894..3246094) Shigella dysenteriae Sd197 3797800 YP_404981.1 CDS kefB NC_007606.1 3246104 3247648 R K+ efflux; Code: P; COG: COG1226; NEM-activable K+/H+ antiporter complement(3246104..3247648) Shigella dysenteriae Sd197 3797801 YP_404982.1 CDS yheR NC_007606.1 3247648 3248202 R required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG complement(3247648..3248202) Shigella dysenteriae Sd197 3797802 YP_404983.1 CDS yheS NC_007606.1 3248330 3250243 D Code: R; COG: COG0488; ABC transporter ATP-binding protein 3248330..3250243 Shigella dysenteriae Sd197 3797803 YP_404984.1 CDS yheT NC_007606.1 3250243 3251265 D Code: R; COG: COG0429; hydrolase 3250243..3251265 Shigella dysenteriae Sd197 3797804 YP_404985.1 CDS yheU NC_007606.1 3251259 3251477 D Code: S; COG: COG3089; hypothetical protein 3251259..3251477 Shigella dysenteriae Sd197 3797805 YP_404986.1 CDS yhfA NC_007606.1 3252456 3252860 R Code: O; COG: COG1765; hypothetical protein complement(3252456..3252860) Shigella dysenteriae Sd197 3798119 YP_404987.1 CDS crp NC_007606.1 3253162 3253794 D complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3253162..3253794 Shigella dysenteriae Sd197 3798120 YP_404988.1 CDS yhfK NC_007606.1 3253845 3255935 D Code: S; COG: COG1289; hypothetical protein 3253845..3255935 Shigella dysenteriae Sd197 3798121 YP_404989.1 CDS argD NC_007606.1 3256002 3257222 R ''DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate''; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase complement(3256002..3257222) Shigella dysenteriae Sd197 3798122 YP_404990.1 CDS pabA NC_007606.1 3257308 3257871 R aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II complement(3257308..3257871) Shigella dysenteriae Sd197 3798123 YP_404991.1 CDS fic NC_007606.1 3257903 3258505 R induced in stationary phase, recognized by rpoS, affects cell division; Code: D; COG: COG2184; cell filamentation protein Fic complement(3257903..3258505) Shigella dysenteriae Sd197 3798124 YP_404992.1 CDS yhfG NC_007606.1 3258495 3258662 R hypothetical protein complement(3258495..3258662) Shigella dysenteriae Sd197 3798125 YP_404993.1 CDS ppiA NC_007606.1 3258767 3259339 R rotamase A; Code: O; COG: COG0652; peptidyl-prolyl cis-trans isomerase A complement(3258767..3259339) Shigella dysenteriae Sd197 3798126 YP_404994.1 CDS yhfC NC_007606.1 3259610 3260791 D Code: GEPR; COG: COG0477; hypothetical protein 3259610..3260791 Shigella dysenteriae Sd197 3798127 YP_404995.1 CDS nirB NC_007606.1 3261053 3263596 D Code: C; COG: COG1251; nitrite reductase (NAD(P)H) subunit 3261053..3263596 Shigella dysenteriae Sd197 3798128 YP_404996.1 CDS nirD NC_007606.1 3263593 3263919 D ''involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations''; nitrite reductase small subunit 3263593..3263919 Shigella dysenteriae Sd197 3798129 YP_404997.1 CDS nirC NC_007606.1 3264045 3264851 D member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3264045..3264851 Shigella dysenteriae Sd197 3798130 YP_404998.1 CDS cysG NC_007606.1 3264870 3266243 D sirohaeme biosynthesis; ''multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin''; siroheme synthase 3264870..3266243 Shigella dysenteriae Sd197 3798131 YP_404999.1 CDS SDY_3531 NC_007606.1 3266260 3266655 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3266260..3266655) Shigella dysenteriae Sd197 3798132 YP_405000.1 CDS gadA NC_007606.1 3266877 3268271 D Code: E; COG: COG0076; glutamate decarboxylase 3266877..3268271 Shigella dysenteriae Sd197 3798133 YP_405001.1 CDS yhiX NC_007606.1 3268639 3269463 D regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 3268639..3269463 Shigella dysenteriae Sd197 3798134 YP_405002.1 CDS SDY_3535 NC_007606.1 3269965 3270360 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(3269965..3270360) Shigella dysenteriae Sd197 3798136 YP_405004.1 CDS yhiV NC_007606.1 3271688 3274807 R Code: V; COG: COG0841; transport system permease complement(3271688..3274807) Shigella dysenteriae Sd197 3796766 YP_405005.1 CDS yhiU NC_007606.1 3274832 3275986 R ''with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds''; multidrug efflux system protein MdtE complement(3274832..3275986) Shigella dysenteriae Sd197 3796767 YP_405006.1 CDS yhiE NC_007606.1 3276325 3276852 R Code: K; COG: COG2771; hypothetical protein complement(3276325..3276852) Shigella dysenteriae Sd197 3796768 YP_405007.1 CDS insA NC_007606.1 3277570 3277845 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3277570..3277845 Shigella dysenteriae Sd197 3796769 YP_405008.1 CDS insB NC_007606.1 3277890 3278267 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3277890..3278267 Shigella dysenteriae Sd197 3796770 YP_405009.1 CDS hdeD NC_007606.1 3278429 3279001 R Code: S; COG: COG3247; acid-resistance membrane protein complement(3278429..3279001) Shigella dysenteriae Sd197 3796771 YP_405010.1 CDS hdeA NC_007606.1 3279256 3279588 D inactive form; acid-resistance protein 3279256..3279588 Shigella dysenteriae Sd197 3796772 YP_405011.1 CDS hdeB NC_007606.1 3279692 3280030 D acid-resistance protein 3279692..3280030 Shigella dysenteriae Sd197 3796773 YP_405012.1 CDS SDY_3546 NC_007606.1 3280366 3280761 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(3280366..3280761) Shigella dysenteriae Sd197 3796775 YP_009000828.1 CDS SDY_4756 NC_007606.1 3280788 3281060 R insertion element iso-IS1N protein InsA complement(3280788..3281060) Shigella dysenteriae Sd197 18263142 YP_405013.1 CDS hmuV NC_007606.1 3281566 3282336 R with HmuTU is involved in the transport of hemin; hemin importer ATP-binding subunit complement(3281566..3282336) Shigella dysenteriae Sd197 3796776 YP_405014.1 CDS shuU NC_007606.1 3282333 3283289 R Code: P; COG: COG0609; iron compound ABC transporter permease complement(3282333..3283289) Shigella dysenteriae Sd197 3796777 YP_405015.1 CDS shuY NC_007606.1 3283376 3283999 R Code: MG; COG: COG0702; hypothetical protein complement(3283376..3283999) Shigella dysenteriae Sd197 3796778 YP_405016.1 CDS shuX NC_007606.1 3283999 3284493 R Code: P; COG: COG3721; hypothetical protein complement(3283999..3284493) Shigella dysenteriae Sd197 3796779 YP_405017.1 CDS shuT NC_007606.1 3285863 3286855 R Code: P; COG: COG4558; periplasmic binding protein complement(3285863..3286855) Shigella dysenteriae Sd197 3796781 YP_405018.1 CDS SDY_3553 NC_007606.1 3286885 3287181 D hypothetical protein 3286885..3287181 Shigella dysenteriae Sd197 3796782 YP_405019.1 CDS shuA NC_007606.1 3287457 3289439 D Code: P; COG: COG1629; outer membrane heme/hemoglobin receptor 3287457..3289439 Shigella dysenteriae Sd197 3796783 YP_405020.1 CDS shuS NC_007606.1 3289488 3290516 D Code: P; COG: COG3720; heme/hemoglobin transport protein 3289488..3290516 Shigella dysenteriae Sd197 3796784 YP_405021.1 CDS yhiF NC_007606.1 3290577 3291107 R Code: K; COG: COG2771; hypothetical protein complement(3290577..3291107) Shigella dysenteriae Sd197 3799940 YP_405022.1 CDS slp NC_007606.1 3291263 3291862 R Code: M; COG: COG3065; hypothetical protein complement(3291263..3291862) Shigella dysenteriae Sd197 3799941 YP_009000829.1 CDS SDY_4757 NC_007606.1 3292224 3292496 D insertion element iso-IS1N protein InsA 3292224..3292496 Shigella dysenteriae Sd197 18263143 YP_405023.1 CDS SDY_3558 NC_007606.1 3292523 3292918 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3292523..3292918 Shigella dysenteriae Sd197 3799942 YP_405024.1 CDS arsC NC_007606.1 3293052 3293477 R Code: P; COG: COG1393; arsenate reductase complement(3293052..3293477) Shigella dysenteriae Sd197 3799943 YP_405025.1 CDS arsB NC_007606.1 3293490 3294800 R Code: P; COG: COG1055; arsenical pump membrane protein complement(3293490..3294800) Shigella dysenteriae Sd197 3799944 YP_405026.1 CDS arsR NC_007606.1 3294834 3295187 R regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR complement(3294834..3295187) Shigella dysenteriae Sd197 3799945 YP_405027.1 CDS gor NC_007606.1 3296067 3297419 R catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase complement(3296067..3297419) Shigella dysenteriae Sd197 3799946 YP_405028.1 CDS yhiR NC_007606.1 3297491 3298333 R Code: R; COG: COG2961; hypothetical protein complement(3297491..3298333) Shigella dysenteriae Sd197 3799947 YP_405029.1 CDS prlC NC_007606.1 3298536 3300578 D Code: E; COG: COG0339; oligopeptidase A 3298536..3300578 Shigella dysenteriae Sd197 3799948 YP_405030.1 CDS yhiQ NC_007606.1 3300584 3301336 D predicted SAM-dependent methyltransferase; methyltransferase 3300584..3301336 Shigella dysenteriae Sd197 3799949 YP_405032.1 CDS uspA NC_007606.1 3303167 3303601 R Code: T; COG: COG0589; universal stress protein complement(3303167..3303601) Shigella dysenteriae Sd197 3799951 YP_405033.1 CDS yhiO NC_007606.1 3303992 3304327 D ''ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress''; universal stress protein UspB 3303992..3304327 Shigella dysenteriae Sd197 3799952 YP_405034.1 CDS pitA NC_007606.1 3304398 3305897 R Code: P; COG: COG0306; low-affinity phosphate transport protein complement(3304398..3305897) Shigella dysenteriae Sd197 3799953 YP_405035.1 CDS yhiN NC_007606.1 3306129 3307331 D Code: R; COG: COG2081; hypothetical protein 3306129..3307331 Shigella dysenteriae Sd197 3799954 YP_009000830.1 CDS SDY_4758 NC_007606.1 3307396 3307668 D insertion element iso-IS1N protein InsA 3307396..3307668 Shigella dysenteriae Sd197 18263144 YP_405039.1 CDS glgP NC_007606.1 3308987 3311434 R Code: G; COG: COG0058; glycogen phosphorylase complement(3308987..3311434) Shigella dysenteriae Sd197 3799958 YP_405040.1 CDS glgA NC_007606.1 3311453 3312886 R ''catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose''; glycogen synthase complement(3311453..3312886) Shigella dysenteriae Sd197 3799959 YP_405041.1 CDS glgC NC_007606.1 3312886 3314181 R catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase complement(3312886..3314181) Shigella dysenteriae Sd197 3798292 YP_405042.1 CDS glgX NC_007606.1 3314199 3316172 R part of glycogen operon, a glycosyl hydrolase, debranching enzyme; ''catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen''; glycogen debranching protein complement(3314199..3316172) Shigella dysenteriae Sd197 3798293 YP_405043.1 CDS glgB NC_007606.1 3316169 3318355 R ''catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain''; glycogen branching protein complement(3316169..3318355) Shigella dysenteriae Sd197 3798294 YP_405044.1 CDS asd NC_007606.1 3318628 3319731 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(3318628..3319731) Shigella dysenteriae Sd197 3798295 YP_405045.1 CDS yhgN NC_007606.1 3319923 3320516 D ''YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP)''; dITP- and XTP- hydrolase 3319923..3320516 Shigella dysenteriae Sd197 3798296 YP_405046.1 CDS SDY_3581 NC_007606.1 3320562 3321857 R Code: LU; COG: COG0758; DNA processing protein complement(3320562..3321857) Shigella dysenteriae Sd197 3798297 YP_405047.1 CDS SDY_3582 NC_007606.1 3322235 3322723 R hypothetical protein complement(3322235..3322723) Shigella dysenteriae Sd197 3798298 YP_009000831.1 CDS SDY_4759 NC_007606.1 3322703 3322975 D insertion element iso-IS1N protein InsA 3322703..3322975 Shigella dysenteriae Sd197 18263145 YP_405048.1 CDS SDY_3583 NC_007606.1 3323002 3323397 D Code: L; COG: COG1662; insertion element IS1 protein InsB 3323002..3323397 Shigella dysenteriae Sd197 3798299 YP_405049.1 CDS insA NC_007606.1 3323545 3323820 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3323545..3323820 Shigella dysenteriae Sd197 3798300 YP_405050.1 CDS insB NC_007606.1 3323865 3324242 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3323865..3324242 Shigella dysenteriae Sd197 3798301 YP_405051.1 CDS SDY_3586 NC_007606.1 3324253 3325410 R Code: L; COG: COG0514; hypothetical protein complement(3324253..3325410) Shigella dysenteriae Sd197 3798302 YP_405052.1 CDS gntU NC_007606.1 3325550 3326890 R Code: GE; COG: COG2610; low affinity gluconate transporter complement(3325550..3326890) Shigella dysenteriae Sd197 3798303 YP_405053.2 CDS gntK NC_007606.1 3326894 3327421 R thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase complement(3326894..3327421) Shigella dysenteriae Sd197 3798304 YP_405054.1 CDS gntR NC_007606.1 3327560 3328498 R regulator of gnt operon; Code: K; COG: COG1609; gluconate operon regulator complement(3327560..3328498) Shigella dysenteriae Sd197 3798305 YP_405055.1 CDS yhhW NC_007606.1 3328681 3329466 R Code: R; COG: COG1741; hypothetical protein complement(3328681..3329466) Shigella dysenteriae Sd197 3798306 YP_405056.1 CDS yhhX NC_007606.1 3329589 3330626 R Code: R; COG: COG0673; dehydrogenase complement(3329589..3330626) Shigella dysenteriae Sd197 3798307 YP_009000832.1 CDS SDY_4760 NC_007606.1 3331369 3331641 D insertion element iso-IS1N protein InsA 3331369..3331641 Shigella dysenteriae Sd197 18263146 YP_405059.1 CDS ggt NC_007606.1 3332237 3333982 R periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase complement(3332237..3333982) Shigella dysenteriae Sd197 3796650 YP_405060.1 CDS yhhA NC_007606.1 3334102 3334542 D hypothetical protein 3334102..3334542 Shigella dysenteriae Sd197 3796651 YP_405061.1 CDS ugpE NC_007606.1 3336330 3337175 R with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate ABC transporter permease complement(3336330..3337175) Shigella dysenteriae Sd197 3796654 YP_405062.1 CDS ugpA NC_007606.1 3337172 3338059 R with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate ABC transporter permease complement(3337172..3338059) Shigella dysenteriae Sd197 3796655 YP_405063.1 CDS ugpB NC_007606.1 3338157 3339473 R with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate ABC transporter substrate-binding protein complement(3338157..3339473) Shigella dysenteriae Sd197 3796656 YP_405064.1 CDS SDY_3602 NC_007606.1 3339833 3340579 R Code: S; COG: COG4700; hypothetical protein complement(3339833..3340579) Shigella dysenteriae Sd197 3796657 YP_405065.2 CDS livF NC_007606.1 3340698 3341411 R ''with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine''; leucine/isoleucine/valine ABC transporter ATP-binding protein complement(3340698..3341411) Shigella dysenteriae Sd197 3796658 YP_405066.1 CDS livG NC_007606.1 3341413 3342180 R ''Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine''; leucine/isoleucine/valine ABC transporter ATP-binding protein complement(3341413..3342180) Shigella dysenteriae Sd197 3796659 YP_405067.1 CDS livM NC_007606.1 3342177 3343454 R ''Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine''; leucine/isoleucine/valine ABC transporter permease complement(3342177..3343454) Shigella dysenteriae Sd197 3796660 YP_405068.1 CDS livH NC_007606.1 3343451 3344299 R Code: E; COG: COG0559; high-affinity branched-chain amino acid transport system permease complement(3343451..3344299) Shigella dysenteriae Sd197 3796661 YP_405069.1 CDS livK NC_007606.1 3344347 3345456 R Code: E; COG: COG0683; high-affinity leucine-specific transport system substrate-binding protein complement(3344347..3345456) Shigella dysenteriae Sd197 3796662 YP_405070.1 CDS insB NC_007606.1 3345525 3345902 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(3345525..3345902) Shigella dysenteriae Sd197 3796663 YP_405071.1 CDS insA NC_007606.1 3345947 3346222 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3345947..3346222) Shigella dysenteriae Sd197 3796664 YP_405072.1 CDS yhhK NC_007606.1 3346657 3347040 D hypothetical protein 3346657..3347040 Shigella dysenteriae Sd197 3796665 YP_405073.1 CDS livJ NC_007606.1 3347240 3348400 R Code: E; COG: COG0683; high-affinity amino acid transport system substrate-binding protein complement(3347240..3348400) Shigella dysenteriae Sd197 3796666 YP_405074.1 CDS rpoH NC_007606.1 3348614 3349468 R regulation of proteins induced at high temperatures; binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(3348614..3349468) Shigella dysenteriae Sd197 3796667 YP_405075.1 CDS ftsX NC_007606.1 3349713 3350771 R ''ABC transporter, membrane protein''; cell division protein FtsX complement(3349713..3350771) Shigella dysenteriae Sd197 3796668 YP_405076.1 CDS ftsE NC_007606.1 3350764 3351432 R ''ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions''; cell division protein FtsE complement(3350764..3351432) Shigella dysenteriae Sd197 3796669 YP_405077.1 CDS ftsY NC_007606.1 3351435 3352931 R signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY complement(3351435..3352931) Shigella dysenteriae Sd197 3797860 YP_405078.1 CDS rsmD NC_007606.1 3353081 3353677 D catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3353081..3353677 Shigella dysenteriae Sd197 3797861 YP_405079.1 CDS yhhL NC_007606.1 3353667 3353936 D Code: S; COG: COG3776; hypothetical protein 3353667..3353936 Shigella dysenteriae Sd197 3797862 YP_405080.1 CDS yhhM NC_007606.1 3353939 3354298 R receptor complement(3353939..3354298) Shigella dysenteriae Sd197 3797863 YP_405081.1 CDS zntA NC_007606.1 3355139 3357337 D ''P-type ATPase involved in the export of lead, cadmium, zinc and mercury''; zinc/cadmium/mercury/lead-transporting ATPase 3355139..3357337 Shigella dysenteriae Sd197 3797865 YP_405082.1 CDS yhhP NC_007606.1 3357439 3357684 R TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA complement(3357439..3357684) Shigella dysenteriae Sd197 3797866 YP_405083.1 CDS yhhQ NC_007606.1 3357905 3358570 D Code: S; COG: COG1738; hypothetical protein 3357905..3358570 Shigella dysenteriae Sd197 3797867 YP_405084.2 CDS SDY_3623 NC_007606.1 3358643 3359200 D hypothetical protein 3358643..3359200 Shigella dysenteriae Sd197 3797868 YP_405086.1 CDS SDY_3626 NC_007606.1 3361513 3361908 D Code: L; COG: COG1662; insertion element IS1 protein InsB 3361513..3361908 Shigella dysenteriae Sd197 3797871 YP_405087.1 CDS insB NC_007606.1 3362363 3362740 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(3362363..3362740) Shigella dysenteriae Sd197 3797872 YP_405088.1 CDS insA NC_007606.1 3362785 3363060 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3362785..3363060) Shigella dysenteriae Sd197 3797873 YP_405089.1 CDS SDY_3629 NC_007606.1 3363131 3364360 D ''FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP''; 3-oxoacyl-ACP synthase 3363131..3364360 Shigella dysenteriae Sd197 3797874 YP_405090.1 CDS yhhU NC_007606.1 3364362 3364949 D Code: H; COG: COG2091; holo-(acyl carrier protein) synthase 2 3364362..3364949 Shigella dysenteriae Sd197 3797875 YP_405091.1 CDS nikA NC_007606.1 3365060 3366634 D Code: E; COG: COG0747; nickel periplasmic binding protein 3365060..3366634 Shigella dysenteriae Sd197 3797876 YP_405092.1 CDS nikB NC_007606.1 3366634 3367578 D with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3366634..3367578 Shigella dysenteriae Sd197 3797877 YP_405093.1 CDS nikC NC_007606.1 3367575 3368408 D with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3367575..3368408 Shigella dysenteriae Sd197 3797878 YP_405094.1 CDS nikD NC_007606.1 3368408 3369172 D with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3368408..3369172 Shigella dysenteriae Sd197 3797806 YP_405095.1 CDS nikE NC_007606.1 3369169 3369975 D with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3369169..3369975 Shigella dysenteriae Sd197 3797807 YP_405096.1 CDS yhhG NC_007606.1 3369981 3370382 D Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3369981..3370382 Shigella dysenteriae Sd197 3797808 YP_009000833.1 CDS SDY_4761 NC_007606.1 3370872 3371144 D insertion element iso-IS1N protein InsA 3370872..3371144 Shigella dysenteriae Sd197 18263147 YP_405098.2 CDS SDY_3639 NC_007606.1 3372022 3372417 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3372022..3372417) Shigella dysenteriae Sd197 3797811 YP_009000834.1 CDS SDY_4762 NC_007606.1 3372444 3372716 R insertion element iso-IS1N protein InsA complement(3372444..3372716) Shigella dysenteriae Sd197 18263148 YP_405100.1 CDS SDY_3641 NC_007606.1 3372900 3373373 D Code: GT; COG: COG1762; PTS system transporter subunit IIA 3372900..3373373 Shigella dysenteriae Sd197 3797813 YP_405101.1 CDS SDY_3642 NC_007606.1 3373370 3373651 D Code: G; COG: COG3414; PTS system transporter subunit IIB 3373370..3373651 Shigella dysenteriae Sd197 3797814 YP_405102.1 CDS SDY_3643 NC_007606.1 3373728 3374111 D hypothetical protein 3373728..3374111 Shigella dysenteriae Sd197 3797815 YP_405103.1 CDS insA NC_007606.1 3374220 3374495 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3374220..3374495 Shigella dysenteriae Sd197 3797816 YP_405104.1 CDS insB NC_007606.1 3374540 3374917 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3374540..3374917 Shigella dysenteriae Sd197 3797817 YP_405105.1 CDS SDY_3646 NC_007606.1 3374999 3375532 D hypothetical protein 3374999..3375532 Shigella dysenteriae Sd197 3797818 YP_405108.1 CDS glpD NC_007606.1 3377119 3378624 R in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase complement(3377119..3378624) Shigella dysenteriae Sd197 3797821 YP_405109.1 CDS glpE NC_007606.1 3378814 3379140 D belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 3378814..3379140 Shigella dysenteriae Sd197 3797822 YP_405110.1 CDS glpG NC_007606.1 3379185 3380015 D protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 3379185..3380015 Shigella dysenteriae Sd197 3797823 YP_405111.1 CDS glpR NC_007606.1 3380032 3380790 D ''represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism''; DNA-binding transcriptional repressor GlpR 3380032..3380790 Shigella dysenteriae Sd197 3797824 YP_405112.1 CDS yhgKJ NC_007606.1 3381782 3382813 D ''catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester''; RNA 3'-terminal-phosphate cyclase 3381782..3382813 Shigella dysenteriae Sd197 3796710 YP_405113.1 CDS SDY_3656 NC_007606.1 3382863 3383348 R Code: KR; COG: COG0454; hypothetical protein complement(3382863..3383348) Shigella dysenteriae Sd197 3796711 YP_405114.1 CDS SDY_3657 NC_007606.1 3383339 3383623 R Code: S; COG: COG4453; hypothetical protein complement(3383339..3383623) Shigella dysenteriae Sd197 3796712 YP_405115.1 CDS malT NC_007606.1 3383684 3386383 R Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT complement(3383684..3386383) Shigella dysenteriae Sd197 3796713 YP_405116.1 CDS malP NC_007606.1 3386995 3389388 D Code: G; COG: COG0058; maltodextrin phosphorylase 3386995..3389388 Shigella dysenteriae Sd197 3796714 YP_405117.1 CDS malQ NC_007606.1 3389398 3391482 D amylomaltase; amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 3389398..3391482 Shigella dysenteriae Sd197 3796715 YP_405118.1 CDS gntT NC_007606.1 3391527 3392843 R Code: GE; COG: COG2610; high-affinity gluconate/gluconate transporter permease complement(3391527..3392843) Shigella dysenteriae Sd197 3796716 YP_405119.1 CDS yhgI NC_007606.1 3393204 3393779 R cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein complement(3393204..3393779) Shigella dysenteriae Sd197 3796717 YP_405120.1 CDS bioH NC_007606.1 3394545 3395315 D Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 3394545..3395315 Shigella dysenteriae Sd197 3796718 YP_405121.1 CDS yhgA NC_007606.1 3395342 3396220 R Code: S; COG: COG5464; hypothetical protein complement(3395342..3396220) Shigella dysenteriae Sd197 3796720 YP_405122.1 CDS yhgG NC_007606.1 3396423 3396659 R hypothetical protein complement(3396423..3396659) Shigella dysenteriae Sd197 3796721 YP_405123.1 CDS feoB NC_007606.1 3396659 3398980 R cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B complement(3396659..3398980) Shigella dysenteriae Sd197 3796722 YP_405124.1 CDS feoA NC_007606.1 3398997 3399224 R Code: P; COG: COG1918; ferrous iron transport protein A complement(3398997..3399224) Shigella dysenteriae Sd197 3796723 YP_405125.1 CDS yhgF NC_007606.1 3399681 3401903 R Code: K; COG: COG2183; hypothetical protein complement(3399681..3401903) Shigella dysenteriae Sd197 3796724 YP_405126.1 CDS greB NC_007606.1 3402099 3402575 R ''necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus''; transcription elongation factor GreB complement(3402099..3402575) Shigella dysenteriae Sd197 3796725 YP_405127.1 CDS ompR NC_007606.1 3402803 3403522 D sensor, EnvZ; outer membrane protein synthesis; part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 3402803..3403522 Shigella dysenteriae Sd197 3796726 YP_405128.1 CDS envZ NC_007606.1 3403519 3404871 D modulates expression of ompF and ompC; membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 3403519..3404871 Shigella dysenteriae Sd197 3796727 YP_405129.1 CDS pckA NC_007606.1 3404947 3406569 R PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase complement(3404947..3406569) Shigella dysenteriae Sd197 3797748 YP_405130.1 CDS yhgE NC_007606.1 3406949 3408673 D transporter 3406949..3408673 Shigella dysenteriae Sd197 3797749 YP_009000835.1 CDS SDY_4763 NC_007606.1 3409164 3409436 R insertion element iso-IS1N protein InsA complement(3409164..3409436) Shigella dysenteriae Sd197 18263149 YP_405133.2 CDS hslO NC_007606.1 3409509 3410387 R ''becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers''; heat shock protein 33 complement(3409509..3410387) Shigella dysenteriae Sd197 3797752 YP_405134.1 CDS yrfH NC_007606.1 3410412 3410813 R Code: J; COG: COG1188; ribosome-associated heat shock protein Hsp15 complement(3410412..3410813) Shigella dysenteriae Sd197 3797753 YP_405135.1 CDS yrfG NC_007606.1 3410824 3411537 R Code: R; COG: COG1011; phosphatase complement(3410824..3411537) Shigella dysenteriae Sd197 3797754 YP_405136.1 CDS yrfF NC_007606.1 3411557 3413692 R dehydrogenase complement(3411557..3413692) Shigella dysenteriae Sd197 3797755 YP_405137.1 CDS nudE NC_007606.1 3414012 3414572 D ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 3414012..3414572 Shigella dysenteriae Sd197 3797756 YP_405138.2 CDS mrcA NC_007606.1 3414737 3417289 R penicillin-binding protein 1A; bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase complement(3414737..3417289) Shigella dysenteriae Sd197 3797757 YP_405141.1 CDS yrfC NC_007606.1 3418188 3418727 D Code: NU; COG: COG3166; hypothetical protein 3418188..3418727 Shigella dysenteriae Sd197 3797760 YP_405142.1 CDS yrfB NC_007606.1 3418711 3419091 D hypothetical protein 3418711..3419091 Shigella dysenteriae Sd197 3797761 YP_405143.1 CDS yrfA NC_007606.1 3419101 3419544 D hypothetical protein 3419101..3419544 Shigella dysenteriae Sd197 3797762 YP_405144.1 CDS aroK NC_007606.1 3421095 3421616 D type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 3421095..3421616 Shigella dysenteriae Sd197 3797764 YP_405145.1 CDS aroB NC_007606.1 3421673 3422761 D catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 3421673..3422761 Shigella dysenteriae Sd197 3797765 YP_405146.1 CDS damX NC_007606.1 3422853 3424130 D interferes with cell division; Code: S; COG: COG3266; hypothetical protein 3422853..3424130 Shigella dysenteriae Sd197 3797766 YP_405147.1 CDS dam NC_007606.1 3424237 3425073 D Code: L; COG: COG0338; DNA adenine methylase 3424237..3425073 Shigella dysenteriae Sd197 3797767 YP_405148.1 CDS rpe NC_007606.1 3425091 3425768 D catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 3425091..3425768 Shigella dysenteriae Sd197 3798138 YP_405149.1 CDS gph NC_007606.1 3425761 3426519 D catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 3425761..3426519 Shigella dysenteriae Sd197 3798139 YP_405150.1 CDS trpS NC_007606.1 3426512 3427516 D ''catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''; tryptophanyl-tRNA synthetase 3426512..3427516 Shigella dysenteriae Sd197 3798140 YP_405151.2 CDS yhfZ NC_007606.1 3427784 3428689 D hypothetical protein 3427784..3428689 Shigella dysenteriae Sd197 3798141 YP_405152.1 CDS SDY_3698 NC_007606.1 3428847 3429212 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 3428847..3429212 Shigella dysenteriae Sd197 3798143 YP_405153.2 CDS SDY_3699 NC_007606.1 3429170 3430075 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3429170..3430075 Shigella dysenteriae Sd197 3798144 YP_405154.1 CDS yhfW NC_007606.1 3431652 3432878 D Code: G; COG: COG1015; mutase 3431652..3432878 Shigella dysenteriae Sd197 3798146 YP_405155.1 CDS yhfV NC_007606.1 3432875 3433753 D phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); hydrolase 3432875..3433753 Shigella dysenteriae Sd197 3798147 YP_405156.1 CDS SDY_3704 NC_007606.1 3434305 3434700 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3434305..3434700) Shigella dysenteriae Sd197 3798149 YP_009000836.1 CDS SDY_4764 NC_007606.1 3434727 3434999 R insertion element iso-IS1N protein InsA complement(3434727..3434999) Shigella dysenteriae Sd197 18263150 YP_405157.1 CDS SDY_3705 NC_007606.1 3434922 3435623 D Code: K; COG: COG2207; transcriptional regulator 3434922..3435623 Shigella dysenteriae Sd197 3798150 YP_405158.1 CDS yiaI NC_007606.1 3435867 3436340 D Code: C; COG: COG1142; hypothetical protein 3435867..3436340 Shigella dysenteriae Sd197 3798151 YP_405159.1 CDS avtA NC_007606.1 3436379 3437632 R transaminase C; ''transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis''; valine--pyruvate transaminase complement(3436379..3437632) Shigella dysenteriae Sd197 3798152 YP_405160.1 CDS bax NC_007606.1 3440160 3440984 D Code: R; COG: COG2992; hypothetical protein 3440160..3440984 Shigella dysenteriae Sd197 3798154 YP_405161.1 CDS xylR NC_007606.1 3441092 3442270 R Code: K; COG: COG1609; xyl operon regulator complement(3441092..3442270) Shigella dysenteriae Sd197 3798155 YP_009000837.1 CDS SDY_4765 NC_007606.1 3442777 3443049 R insertion element iso-IS1N protein InsA complement(3442777..3443049) Shigella dysenteriae Sd197 18263151 YP_405167.1 CDS purH NC_007606.1 3450399 3451988 D AICAR formyltransferase; IMP cyclohydrolase; involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 3450399..3451988 Shigella dysenteriae Sd197 3797210 YP_405168.1 CDS purD NC_007606.1 3452000 3453289 D GAR synthetase; catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 3452000..3453289 Shigella dysenteriae Sd197 3797211 YP_405169.1 CDS hydG NC_007606.1 3453286 3454611 R DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulator ZraR complement(3453286..3454611) Shigella dysenteriae Sd197 3797212 YP_405170.1 CDS hydH NC_007606.1 3454608 3455984 R Code: T; COG: COG0642; sensor protein ZraS complement(3454608..3455984) Shigella dysenteriae Sd197 3797213 YP_405171.2 CDS zraP NC_007606.1 3456222 3456641 D Code: UNTP; COG: COG3678; zinc resistance protein 3456222..3456641 Shigella dysenteriae Sd197 3797214 YP_405172.1 CDS yjaH NC_007606.1 3456643 3457338 R hypothetical protein complement(3456643..3457338) Shigella dysenteriae Sd197 3797215 YP_405173.1 CDS hupA NC_007606.1 3457351 3457623 R HU-2; histone-like DNA-binding protein; transcriptional regulator HU subunit alpha complement(3457351..3457623) Shigella dysenteriae Sd197 3797216 YP_405174.1 CDS yjaG NC_007606.1 3457810 3458400 R Code: S; COG: COG3068; hypothetical protein complement(3457810..3458400) Shigella dysenteriae Sd197 3797217 YP_405175.1 CDS nfi NC_007606.1 3458443 3459114 R deoxyinosine 3'endoduclease; ''Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures''; endonuclease V complement(3458443..3459114) Shigella dysenteriae Sd197 3798272 YP_405176.1 CDS hemE NC_007606.1 3459124 3460188 R catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase complement(3459124..3460188) Shigella dysenteriae Sd197 3798273 YP_405177.1 CDS nudC NC_007606.1 3460228 3461001 R can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase complement(3460228..3461001) Shigella dysenteriae Sd197 3798274 YP_405178.1 CDS yjaE NC_007606.1 3461096 3461572 D binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 3461096..3461572 Shigella dysenteriae Sd197 3798275 YP_405179.1 CDS thiC NC_007606.1 3461806 3463701 D required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 3461806..3463701 Shigella dysenteriae Sd197 3798276 YP_405180.1 CDS thiE NC_007606.1 3463701 3464336 D catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 3463701..3464336 Shigella dysenteriae Sd197 3798277 YP_405181.2 CDS thiF NC_007606.1 3464329 3465084 D Code: H; COG: COG0476; thiazole biosynthesis adenylyltransferase ThiF 3464329..3465084 Shigella dysenteriae Sd197 3798278 YP_405182.1 CDS thiS NC_007606.1 3465068 3465268 D ''with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate''; sulfur carrier protein ThiS 3465068..3465268 Shigella dysenteriae Sd197 3798279 YP_405183.2 CDS thiG NC_007606.1 3465270 3466040 D functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 3465270..3466040 Shigella dysenteriae Sd197 3798280 YP_405184.1 CDS thiH NC_007606.1 3466037 3467170 D ''in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center''; thiamine biosynthesis protein ThiH 3466037..3467170 Shigella dysenteriae Sd197 3798281 YP_009000838.1 CDS SDY_4766 NC_007606.1 3467840 3468112 D insertion element iso-IS1N protein InsA 3467840..3468112 Shigella dysenteriae Sd197 18263152 YP_405185.1 CDS SDY_3738 NC_007606.1 3468139 3468534 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3468139..3468534 Shigella dysenteriae Sd197 3798282 YP_405186.1 CDS rpoC NC_007606.1 3469106 3473329 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(3469106..3473329) Shigella dysenteriae Sd197 3798284 YP_405187.1 CDS rpoB NC_007606.1 3473406 3477434 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(3473406..3477434) Shigella dysenteriae Sd197 3798285 YP_405188.1 CDS rplL NC_007606.1 3477743 3478108 R ''present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors''; 50S ribosomal protein L7/L12 complement(3477743..3478108) Shigella dysenteriae Sd197 3798286 YP_405189.1 CDS rplJ NC_007606.1 3478175 3478672 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(3478175..3478672) Shigella dysenteriae Sd197 3798287 YP_405190.1 CDS rplA NC_007606.1 3479085 3479789 R regulates synthesis of L1 and L11; ''in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA''; 50S ribosomal protein L1 complement(3479085..3479789) Shigella dysenteriae Sd197 3798288 YP_405191.1 CDS rplK NC_007606.1 3479793 3480221 R binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 complement(3479793..3480221) Shigella dysenteriae Sd197 3798289 YP_405192.1 CDS nusG NC_007606.1 3480380 3480925 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(3480380..3480925) Shigella dysenteriae Sd197 3798290 YP_405193.1 CDS secE NC_007606.1 3480927 3481310 R ''forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force''; preprotein translocase subunit SecE complement(3480927..3481310) Shigella dysenteriae Sd197 3798291 YP_405194.1 CDS tufB NC_007606.1 3481540 3482724 R ''EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu''; elongation factor Tu complement(3481540..3482724) Shigella dysenteriae Sd197 3797937 YP_405196.1 CDS coaA NC_007606.1 3483642 3484592 D catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 3483642..3484592 Shigella dysenteriae Sd197 3797943 YP_405197.1 CDS birA NC_007606.1 3484621 3485586 R ''catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon''; biotin--protein ligase complement(3484621..3485586) Shigella dysenteriae Sd197 3797944 YP_405198.1 CDS murB NC_007606.1 3485583 3486611 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(3485583..3486611) Shigella dysenteriae Sd197 3797945 YP_405199.2 CDS murI NC_007606.1 3492121 3492978 R required for biosynthesis of D-glutamate and peptidoglycan; ''converts L-glutamate to D-glutamate, a component of peptidoglycan''; glutamate racemase complement(3492121..3492978) Shigella dysenteriae Sd197 3798619 YP_405200.1 CDS btuB NC_007606.1 3492923 3494767 R involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter complement(3492923..3494767) Shigella dysenteriae Sd197 3798620 YP_405201.1 CDS trmA NC_007606.1 3495136 3496236 D catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 3495136..3496236 Shigella dysenteriae Sd197 3798621 YP_405202.1 CDS yijD NC_007606.1 3496276 3496635 R hypothetical protein complement(3496276..3496635) Shigella dysenteriae Sd197 3798622 YP_405203.1 CDS yijC NC_007606.1 3496635 3497339 R ''negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis''; DNA-binding transcriptional repressor FabR complement(3496635..3497339) Shigella dysenteriae Sd197 3798623 YP_405205.1 CDS insB NC_007606.1 3498300 3498677 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3498300..3498677 Shigella dysenteriae Sd197 3798625 YP_405209.1 CDS yiiX NC_007606.1 3501678 3502286 R member of the NlpC/P60 superfamily of peptidases; peptidoglycan peptidase complement(3501678..3502286) Shigella dysenteriae Sd197 3798630 YP_405210.1 CDS metJ NC_007606.1 3502346 3502663 R when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor MetJ complement(3502346..3502663) Shigella dysenteriae Sd197 3798631 YP_405211.1 CDS metB NC_007606.1 3502940 3504100 D catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 3502940..3504100 Shigella dysenteriae Sd197 3798632 YP_405212.1 CDS metL NC_007606.1 3504103 3506535 D multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 3504103..3506535 Shigella dysenteriae Sd197 3798633 YP_405213.1 CDS metF NC_007606.1 3506884 3507774 D ''MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor''; 5,10-methylenetetrahydrofolate reductase 3506884..3507774 Shigella dysenteriae Sd197 3798634 YP_405214.1 CDS yijE NC_007606.1 3510276 3511214 D Code: GER; COG: COG0697; hypothetical protein 3510276..3511214 Shigella dysenteriae Sd197 3798636 YP_405215.1 CDS yijF NC_007606.1 3511241 3511858 R Code: S; COG: COG3738; hypothetical protein complement(3511241..3511858) Shigella dysenteriae Sd197 3798505 YP_405216.2 CDS gldA NC_007606.1 3512132 3513235 R forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase complement(3512132..3513235) Shigella dysenteriae Sd197 3798506 YP_405217.1 CDS talC NC_007606.1 3513246 3513908 R similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase complement(3513246..3513908) Shigella dysenteriae Sd197 3798507 YP_405218.1 CDS ptsA NC_007606.1 3513920 3516055 R Code: G; COG: COG1080; PTS system transporter subunit I phosphoenolpyruvate-protein kinase /IIA complement(3513920..3516055) Shigella dysenteriae Sd197 3798508 YP_405220.1 CDS frwC NC_007606.1 3516730 3517809 D ''FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site''; PTS system fructose-like transporter subunit IIC 3516730..3517809 Shigella dysenteriae Sd197 3798510 YP_405221.1 CDS frwB NC_007606.1 3517824 3518144 D ''FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS''; PTS system fructose-like transporter subunit IIB 3517824..3518144 Shigella dysenteriae Sd197 3798511 YP_405222.1 CDS pflD NC_007606.1 3518195 3520492 D involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 3518195..3520492 Shigella dysenteriae Sd197 3798512 YP_405223.1 CDS pflC NC_007606.1 3520458 3521336 D Code: O; COG: COG1180; pyruvate formate lyase II activase 3520458..3521336 Shigella dysenteriae Sd197 3798513 YP_405224.1 CDS frwD NC_007606.1 3521338 3521679 D ''FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog''; PTS system fructose-like transporter subunit IIB 3521338..3521679 Shigella dysenteriae Sd197 3798514 YP_405225.1 CDS yijO NC_007606.1 3521666 3522517 R Code: K; COG: COG2207; AraC family transcriptional regulator complement(3521666..3522517) Shigella dysenteriae Sd197 3798515 YP_405226.1 CDS yijP NC_007606.1 3522666 3524399 R Code: R; COG: COG2194; hypothetical protein complement(3522666..3524399) Shigella dysenteriae Sd197 3798516 YP_405227.1 CDS ppc NC_007606.1 3524581 3527232 R catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase complement(3524581..3527232) Shigella dysenteriae Sd197 3798517 YP_405228.1 CDS argE NC_007606.1 3527707 3528858 R catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase complement(3527707..3528858) Shigella dysenteriae Sd197 3798518 YP_405229.1 CDS argC NC_007606.1 3529012 3530016 D ''catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate''; N-acetyl-gamma-glutamyl-phosphate reductase 3529012..3530016 Shigella dysenteriae Sd197 3798519 YP_405230.2 CDS argB NC_007606.1 3530027 3530800 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 3530027..3530800 Shigella dysenteriae Sd197 3798520 YP_405231.1 CDS argH NC_007606.1 3530861 3532234 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 3530861..3532234 Shigella dysenteriae Sd197 3798521 YP_405232.1 CDS oxyR NC_007606.1 3532501 3533418 D activator of hydrogen peroxide-inducible genes; ''Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA''; DNA-binding transcriptional regulator OxyR 3532501..3533418 Shigella dysenteriae Sd197 3798522 YP_405233.2 CDS udhA NC_007606.1 3533401 3534801 R catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase complement(3533401..3534801) Shigella dysenteriae Sd197 3798523 YP_009000839.1 CDS SDY_4767 NC_007606.1 3535059 3535331 D insertion element iso-IS1N protein InsA 3535059..3535331 Shigella dysenteriae Sd197 18263153 YP_405235.1 CDS SDY_3799 NC_007606.1 3535358 3535753 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3535358..3535753 Shigella dysenteriae Sd197 3799864 YP_405236.1 CDS rhsB NC_007606.1 3535728 3539369 R Code: M; COG: COG3209; rhs element protein RhsB complement(3535728..3539369) Shigella dysenteriae Sd197 3799865 YP_405237.1 CDS rpmE NC_007606.1 3539529 3539741 R ''RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome''; 50S ribosomal protein L31 complement(3539529..3539741) Shigella dysenteriae Sd197 3799866 YP_405238.1 CDS priA NC_007606.1 3539944 3542142 D factor Y; helicase; ''binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity''; primosome assembly protein PriA 3539944..3542142 Shigella dysenteriae Sd197 3799867 YP_405239.1 CDS cytR NC_007606.1 3542298 3543323 D ''negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins''; DNA-binding transcriptional regulator CytR 3542298..3543323 Shigella dysenteriae Sd197 3799868 YP_405240.1 CDS ftsN NC_007606.1 3543415 3544374 D Code: D; COG: COG3087; cell division protein FtsN 3543415..3544374 Shigella dysenteriae Sd197 3799869 YP_405241.1 CDS hslV NC_007606.1 3544467 3544997 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 3544467..3544997 Shigella dysenteriae Sd197 3799870 YP_405242.1 CDS hslU NC_007606.1 3545007 3546338 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 3545007..3546338 Shigella dysenteriae Sd197 3799871 YP_405243.1 CDS menA NC_007606.1 3546405 3547331 D 1,4-dihydroxy-2-naphthoate --> dimethylmenaquinone; ''catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate''; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 3546405..3547331 Shigella dysenteriae Sd197 3799872 YP_405244.1 CDS menG NC_007606.1 3547424 3547909 D regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 3547424..3547909 Shigella dysenteriae Sd197 3799873 YP_405245.1 CDS SDY_3809 NC_007606.1 3547966 3548361 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3547966..3548361) Shigella dysenteriae Sd197 3799874 YP_009000840.1 CDS SDY_4768 NC_007606.1 3548388 3548660 R insertion element iso-IS1N protein InsA complement(3548388..3548660) Shigella dysenteriae Sd197 18263154 YP_405246.1 CDS SDY_3810 NC_007606.1 3548759 3549010 D hypothetical protein 3548759..3549010 Shigella dysenteriae Sd197 3799875 YP_405247.1 CDS insA NC_007606.1 3549146 3549421 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3549146..3549421 Shigella dysenteriae Sd197 3799876 YP_405248.1 CDS insB NC_007606.1 3549466 3549843 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3549466..3549843 Shigella dysenteriae Sd197 3799877 YP_405249.1 CDS SDY_3813 NC_007606.1 3550322 3550624 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 3550322..3550624 Shigella dysenteriae Sd197 3799878 YP_405251.1 CDS SDY_3815 NC_007606.1 3551506 3551802 D hypothetical protein 3551506..3551802 Shigella dysenteriae Sd197 3799880 YP_405252.1 CDS yiiU NC_007606.1 3551841 3552086 R Code: S; COG: COG3074; hypothetical protein complement(3551841..3552086) Shigella dysenteriae Sd197 3799881 YP_405253.1 CDS glpF NC_007606.1 3552512 3553357 D Code: G; COG: COG0580; facilitated diffusion of glycerol 3552512..3553357 Shigella dysenteriae Sd197 3799882 YP_405254.1 CDS glpK NC_007606.1 3553380 3554888 D Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 3553380..3554888 Shigella dysenteriae Sd197 3799265 YP_405255.1 CDS glpX NC_007606.1 3555118 3556128 D unknown function in glycerol metabolism; ''type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese''; fructose 1,6-bisphosphatase II 3555118..3556128 Shigella dysenteriae Sd197 3799266 YP_405256.1 CDS fpr NC_007606.1 3556225 3556971 D Code: C; COG: COG1018; ferredoxin-NADP reductase 3556225..3556971 Shigella dysenteriae Sd197 3799267 YP_405257.1 CDS yiiT NC_007606.1 3556976 3557404 R with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD complement(3556976..3557404) Shigella dysenteriae Sd197 3799268 YP_405258.1 CDS yiiS NC_007606.1 3557407 3557730 R Code: S; COG: COG3691; hypothetical protein complement(3557407..3557730) Shigella dysenteriae Sd197 3799269 YP_405259.1 CDS SDY_3823 NC_007606.1 3557991 3558386 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3557991..3558386) Shigella dysenteriae Sd197 3799270 YP_009000841.1 CDS SDY_4769 NC_007606.1 3558413 3558685 R insertion element iso-IS1N protein InsA complement(3558413..3558685) Shigella dysenteriae Sd197 18263155 YP_405260.1 CDS yiiR NC_007606.1 3558725 3559156 R Code: S; COG: COG3152; hypothetical protein complement(3558725..3559156) Shigella dysenteriae Sd197 3799271 YP_405261.1 CDS yiiQ NC_007606.1 3559257 3559856 D hypothetical protein 3559257..3559856 Shigella dysenteriae Sd197 3799272 YP_405262.1 CDS tpiA NC_007606.1 3559964 3560731 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 3559964..3560731 Shigella dysenteriae Sd197 3799273 YP_405263.1 CDS insB NC_007606.1 3561298 3561675 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(3561298..3561675) Shigella dysenteriae Sd197 3799274 YP_405264.1 CDS insA NC_007606.1 3561720 3561995 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3561720..3561995) Shigella dysenteriae Sd197 3799275 YP_405265.1 CDS sbp NC_007606.1 3562425 3563414 R Code: P; COG: COG1613; sulfate transporter subunit complement(3562425..3563414) Shigella dysenteriae Sd197 3799277 YP_405266.1 CDS pfkA NC_007606.1 3563733 3564695 R ''catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis''; 6-phosphofructokinase complement(3563733..3564695) Shigella dysenteriae Sd197 3799278 YP_405267.1 CDS fieF NC_007606.1 3564876 3565778 R ''member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers''; ferrous iron efflux protein F complement(3564876..3565778) Shigella dysenteriae Sd197 3799279 YP_405268.2 CDS cpxP NC_007606.1 3565926 3566426 R repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; repressor CpxP complement(3565926..3566426) Shigella dysenteriae Sd197 3799280 YP_405269.1 CDS cpxR NC_007606.1 3566576 3567274 D response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 3566576..3567274 Shigella dysenteriae Sd197 3799281 YP_405270.1 CDS cpxA NC_007606.1 3567271 3568644 D probable sensor protein; acting on arcA; part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 3567271..3568644 Shigella dysenteriae Sd197 3799282 YP_405271.2 CDS yiiM NC_007606.1 3568712 3569386 R Code: S; COG: COG2258; hypothetical protein complement(3568712..3569386) Shigella dysenteriae Sd197 3799283 YP_405272.2 CDS kdgT NC_007606.1 3569535 3570521 R transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease complement(3569535..3570521) Shigella dysenteriae Sd197 3798466 YP_405273.1 CDS sodA NC_007606.1 3570781 3571401 R SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase complement(3570781..3571401) Shigella dysenteriae Sd197 3798467 YP_405274.1 CDS rhaT NC_007606.1 3571686 3572720 D transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter 3571686..3572720 Shigella dysenteriae Sd197 3798468 YP_405275.1 CDS rhaR NC_007606.1 3572717 3573655 R activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR complement(3572717..3573655) Shigella dysenteriae Sd197 3798469 YP_405276.1 CDS rhaS NC_007606.1 3573639 3574475 R activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS complement(3573639..3574475) Shigella dysenteriae Sd197 3798470 YP_405277.1 CDS rhaB NC_007606.1 3574763 3575926 D Code: G; COG: COG1070; rhamnulokinase 3574763..3575926 Shigella dysenteriae Sd197 3798471 YP_405278.1 CDS rhaD NC_007606.1 3577181 3578005 D Code: G; COG: COG0235; rhamnulose-1-phosphate aldolase 3577181..3578005 Shigella dysenteriae Sd197 3798473 YP_405279.1 CDS yiiL NC_007606.1 3578015 3578329 D Code: S; COG: COG3254; hypothetical protein 3578015..3578329 Shigella dysenteriae Sd197 3798474 YP_009000842.1 CDS SDY_4770 NC_007606.1 3579074 3579346 R insertion element iso-IS1N protein InsA complement(3579074..3579346) Shigella dysenteriae Sd197 18263156 YP_405281.1 CDS fdhD NC_007606.1 3580174 3581007 R involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein complement(3580174..3581007) Shigella dysenteriae Sd197 3798477 YP_405282.1 CDS fdoG NC_007606.1 3581201 3584251 D Code: C; COG: COG0243; formate dehydrogenase-O, major subunit 3581201..3584251 Shigella dysenteriae Sd197 3798478 YP_405283.1 CDS fdoH NC_007606.1 3584264 3585166 D Code: C; COG: COG0437; formate dehydrogenase-O, iron-sulfur subunit 3584264..3585166 Shigella dysenteriae Sd197 3798479 YP_405284.1 CDS fdoI NC_007606.1 3585163 3585798 D cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 3585163..3585798 Shigella dysenteriae Sd197 3798480 YP_405285.1 CDS fdhE NC_007606.1 3585795 3586724 D required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 3585795..3586724 Shigella dysenteriae Sd197 3798481 YP_405286.1 CDS insB NC_007606.1 3587044 3587421 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(3587044..3587421) Shigella dysenteriae Sd197 3798482 YP_405287.1 CDS insA NC_007606.1 3587466 3587741 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3587466..3587741) Shigella dysenteriae Sd197 3798483 YP_405288.1 CDS yiiD NC_007606.1 3587919 3588908 R Code: KR; COG: COG0454; acetyltransferase complement(3587919..3588908) Shigella dysenteriae Sd197 3798484 YP_405289.1 CDS yihZ NC_007606.1 3588905 3589342 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(3588905..3589342) Shigella dysenteriae Sd197 3798485 YP_405290.1 CDS rbn NC_007606.1 3589339 3590211 R RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN complement(3589339..3590211) Shigella dysenteriae Sd197 3797237 YP_405291.2 CDS yihX NC_007606.1 3590205 3590804 R Code: R; COG: COG1011; phosphatase complement(3590205..3590804) Shigella dysenteriae Sd197 3797238 YP_405295.1 CDS SDY_3862 NC_007606.1 3593155 3593457 R Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN complement(3593155..3593457) Shigella dysenteriae Sd197 3797242 YP_405296.1 CDS SDY_3863 NC_007606.1 3593621 3594352 R hypothetical protein complement(3593621..3594352) Shigella dysenteriae Sd197 3797243 YP_009000843.1 CDS SDY_4771 NC_007606.1 3594623 3594895 D insertion element iso-IS1N protein InsA 3594623..3594895 Shigella dysenteriae Sd197 18263157 YP_405300.1 CDS SDY_3867 NC_007606.1 3595326 3596030 R Code: GEPR; COG: COG0477; shikimate transporter complement(3595326..3596030) Shigella dysenteriae Sd197 3797247 YP_405301.1 CDS insA NC_007606.1 3596178 3596453 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3596178..3596453 Shigella dysenteriae Sd197 3797248 YP_405302.1 CDS insB NC_007606.1 3596498 3596875 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3596498..3596875 Shigella dysenteriae Sd197 3797249 YP_405303.1 CDS SDY_3871 NC_007606.1 3597568 3598914 R Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG complement(3597568..3598914) Shigella dysenteriae Sd197 3797251 YP_405304.1 CDS yihK NC_007606.1 3599019 3600842 R Code: T; COG: COG1217; GTP-binding protein complement(3599019..3600842) Shigella dysenteriae Sd197 3797252 YP_405305.1 CDS glnA NC_007606.1 3601215 3602624 D forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 3601215..3602624 Shigella dysenteriae Sd197 3797253 YP_405306.1 CDS glnL NC_007606.1 3602798 3603847 D nitrogen regulator II, NRII; sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 3602798..3603847 Shigella dysenteriae Sd197 3797254 YP_405307.1 CDS glnG NC_007606.1 3603859 3605268 D sensor glnL; nitrogen regulator I, NRI; response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 3603859..3605268 Shigella dysenteriae Sd197 3797255 YP_405308.2 CDS hemN NC_007606.1 3605680 3607053 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(3605680..3607053) Shigella dysenteriae Sd197 3796992 YP_405309.1 CDS yihI NC_007606.1 3607242 3607748 R Code: S; COG: COG3078; hypothetical protein complement(3607242..3607748) Shigella dysenteriae Sd197 3796993 YP_405310.2 CDS engB NC_007606.1 3608330 3608962 D binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 3608330..3608962 Shigella dysenteriae Sd197 3796994 YP_405311.1 CDS polA NC_007606.1 3609343 3612129 R DNA polymerase I, 3' --> 5' polymerase, 5' --> 3' and 3' --> 5' exonuclease; ''has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair''; DNA polymerase I complement(3609343..3612129) Shigella dysenteriae Sd197 3796995 YP_405312.1 CDS yihG NC_007606.1 3612493 3613425 D Code: I; COG: COG0204; acyltransferase 3612493..3613425 Shigella dysenteriae Sd197 3796996 YP_405313.1 CDS SDY_3881 NC_007606.1 3614226 3614441 R insertion element iso-IS1n protein InsB complement(3614226..3614441) Shigella dysenteriae Sd197 3796997 YP_009000844.1 CDS SDY_4772 NC_007606.1 3614647 3614919 R insertion element iso-IS1N protein InsA complement(3614647..3614919) Shigella dysenteriae Sd197 18263158 YP_405314.1 CDS insB NC_007606.1 3615684 3616061 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(3615684..3616061) Shigella dysenteriae Sd197 3796999 YP_405315.1 CDS insA NC_007606.1 3616106 3616381 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3616106..3616381) Shigella dysenteriae Sd197 3797000 YP_405316.1 CDS dsbA NC_007606.1 3616601 3617227 R essential for cytochrome c synthesis and formate-dependent reduction; Code: OC; COG: COG0526; protein disulfide isomerase complement(3616601..3617227) Shigella dysenteriae Sd197 3797001 YP_405317.1 CDS yihE NC_007606.1 3617244 3618230 R catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase complement(3617244..3618230) Shigella dysenteriae Sd197 3797002 YP_405318.1 CDS yihD NC_007606.1 3618307 3618576 R Code: S; COG: COG3084; hypothetical protein complement(3618307..3618576) Shigella dysenteriae Sd197 3797003 YP_405319.1 CDS mobA NC_007606.1 3618646 3619230 D molybdopterin ---> molybdopterin-guanine dinucleotide, protein Ar; Links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A 3618646..3619230 Shigella dysenteriae Sd197 3797004 YP_405320.1 CDS mobB NC_007606.1 3619227 3619739 D Code: H; COG: COG1763; molybdopterin-guanine dinucleotide biosynthesis protein B 3619227..3619739 Shigella dysenteriae Sd197 3797005 YP_405321.1 CDS hemG NC_007606.1 3625309 3625854 R catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase complement(3625309..3625854) Shigella dysenteriae Sd197 3797011 YP_405322.1 CDS trkH NC_007606.1 3625866 3627317 R requires TrkE; Code: P; COG: COG0168; potassium transporter complement(3625866..3627317) Shigella dysenteriae Sd197 3797012 YP_405323.1 CDS yigZ NC_007606.1 3627356 3627973 R Code: S; COG: COG1739; hypothetical protein complement(3627356..3627973) Shigella dysenteriae Sd197 3797013 YP_405324.1 CDS pepQ NC_007606.1 3627970 3629301 R catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase complement(3627970..3629301) Shigella dysenteriae Sd197 3797014 YP_405325.1 CDS fadB NC_007606.1 3629491 3631680 D 4-enzyme protein; ''includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids''; multifunctional fatty acid oxidation complex subunit alpha 3629491..3631680 Shigella dysenteriae Sd197 3797015 YP_405326.1 CDS fadA NC_007606.1 3631690 3632853 D 3-ketoacyl-CoA thiolase; acetyl-CoA transferase; FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 3631690..3632853 Shigella dysenteriae Sd197 3797016 YP_405327.1 CDS fre NC_007606.1 3633046 3633747 R flavin reductase; NADPH:flavin oxidoreductase; NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase complement(3633046..3633747) Shigella dysenteriae Sd197 3797017 YP_405328.1 CDS yigC NC_007606.1 3633793 3635286 R catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(3633793..3635286) Shigella dysenteriae Sd197 3797018 YP_405329.1 CDS rfaH NC_007606.1 3635453 3635941 D Code: K; COG: COG0250; transcriptional activator RfaH 3635453..3635941 Shigella dysenteriae Sd197 3797019 YP_405330.1 CDS yigU NC_007606.1 3636761 3637537 R with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC complement(3636761..3637537) Shigella dysenteriae Sd197 3797021 YP_405331.2 CDS SDY_3906 NC_007606.1 3637540 3638055 R mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase complement(3637540..3638055) Shigella dysenteriae Sd197 3797022 YP_405332.1 CDS tatA NC_007606.1 3638059 3638370 R TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin-arginine translocation protein TatA complement(3638059..3638370) Shigella dysenteriae Sd197 3797023 YP_405333.1 CDS ubiB NC_007606.1 3638407 3640047 R an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB complement(3638407..3640047) Shigella dysenteriae Sd197 3797024 YP_405334.1 CDS yigP NC_007606.1 3640044 3640649 R Code: S; COG: COG3165; hypothetical protein complement(3640044..3640649) Shigella dysenteriae Sd197 3797025 YP_405335.1 CDS ubiE NC_007606.1 3640663 3641418 R 2-octaprenyl-6-methoxy-1,4-benzoquinone --> 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone; Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase complement(3640663..3641418) Shigella dysenteriae Sd197 3796597 YP_405336.1 CDS yigN NC_007606.1 3641513 3642940 R YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC complement(3641513..3642940) Shigella dysenteriae Sd197 3796598 YP_405337.1 CDS udp NC_007606.1 3643081 3643842 R catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase complement(3643081..3643842) Shigella dysenteriae Sd197 3796599 YP_405338.1 CDS SDY_3913 NC_007606.1 3644050 3644919 D Code: Q; COG: COG0412; dienelactone hydrolase 3644050..3644919 Shigella dysenteriae Sd197 3796600 YP_405339.1 CDS metE NC_007606.1 3644959 3647220 R catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase complement(3644959..3647220) Shigella dysenteriae Sd197 3796601 YP_405340.1 CDS metR NC_007606.1 3647456 3648409 D Code: K; COG: COG0583; metE and metH regulator 3647456..3648409 Shigella dysenteriae Sd197 3796602 YP_405341.1 CDS yigM NC_007606.1 3648297 3649196 R Code: GER; COG: COG0697; hypothetical protein complement(3648297..3649196) Shigella dysenteriae Sd197 3796603 YP_405342.1 CDS SDY_3917 NC_007606.1 3649272 3650072 R ''purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium''; sugar phosphatase complement(3649272..3650072) Shigella dysenteriae Sd197 3796604 YP_405343.1 CDS pldB NC_007606.1 3650080 3651102 R lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 complement(3650080..3651102) Shigella dysenteriae Sd197 3796605 YP_405344.2 CDS yigK NC_007606.1 3651213 3651833 D Code: E; COG: COG1280; hypothetical protein 3651213..3651833 Shigella dysenteriae Sd197 3796606 YP_405345.2 CDS yigJ NC_007606.1 3651895 3652515 R Code: E; COG: COG1280; hypothetical protein complement(3651895..3652515) Shigella dysenteriae Sd197 3796607 YP_405346.1 CDS recQ NC_007606.1 3652579 3654414 R ''functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway''; ATP-dependent DNA helicase RecQ complement(3652579..3654414) Shigella dysenteriae Sd197 3796608 YP_405347.1 CDS pldA NC_007606.1 3654541 3655410 R catalyzes the hydrolysis of phosphatidylcholine; phospholipase A complement(3654541..3655410) Shigella dysenteriae Sd197 3796609 YP_405348.2 CDS yigI NC_007606.1 3655575 3656042 D Code: Q; COG: COG2050; hypothetical protein 3655575..3656042 Shigella dysenteriae Sd197 3796610 YP_405349.1 CDS rarD NC_007606.1 3656094 3656987 D Code: R; COG: COG2962; hypothetical protein 3656094..3656987 Shigella dysenteriae Sd197 3796611 YP_405350.1 CDS insA NC_007606.1 3657107 3657382 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3657107..3657382 Shigella dysenteriae Sd197 3796612 YP_405351.1 CDS insB NC_007606.1 3657427 3657804 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3657427..3657804 Shigella dysenteriae Sd197 3796613 YP_405352.1 CDS insB NC_007606.1 3658262 3658639 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(3658262..3658639) Shigella dysenteriae Sd197 3796614 YP_405353.1 CDS insA NC_007606.1 3658684 3658959 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3658684..3658959) Shigella dysenteriae Sd197 3796615 YP_405354.1 CDS corA NC_007606.1 3659193 3660143 R responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA complement(3659193..3660143) Shigella dysenteriae Sd197 3796616 YP_405355.1 CDS yigE NC_007606.1 3660513 3661277 D Code: S; COG: COG3698; hypothetical protein 3660513..3661277 Shigella dysenteriae Sd197 3797768 YP_405356.1 CDS SDY_3931 NC_007606.1 3661360 3662262 D Code: S; COG: COG1912; hypothetical protein 3661360..3662262 Shigella dysenteriae Sd197 3797769 YP_405357.1 CDS uvrD NC_007606.1 3662317 3664479 R unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II complement(3662317..3664479) Shigella dysenteriae Sd197 3797770 YP_405358.1 CDS yigB NC_007606.1 3664563 3665279 R YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase complement(3664563..3665279) Shigella dysenteriae Sd197 3797771 YP_405359.1 CDS xerC NC_007606.1 3665279 3666175 R acts on cer sequence of ColE1; effects chromosome segregation at cell division; site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC complement(3665279..3666175) Shigella dysenteriae Sd197 3797772 YP_405360.1 CDS yigA NC_007606.1 3666172 3666879 R Code: S; COG: COG3159; hypothetical protein complement(3666172..3666879) Shigella dysenteriae Sd197 3797773 YP_405361.2 CDS dapF NC_007606.1 3666876 3667700 R involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase complement(3666876..3667700) Shigella dysenteriae Sd197 3797774 YP_405362.1 CDS yifL NC_007606.1 3667737 3667940 R Code: N; COG: COG5567; hypothetical protein complement(3667737..3667940) Shigella dysenteriae Sd197 3797775 YP_405363.1 CDS SDY_3939 NC_007606.1 3668127 3668612 R hypothetical protein complement(3668127..3668612) Shigella dysenteriae Sd197 3797777 YP_405364.1 CDS cyaY NC_007606.1 3668403 3668723 D defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 3668403..3668723 Shigella dysenteriae Sd197 3797776 YP_405365.1 CDS cyaA NC_007606.1 3668763 3671309 R catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase complement(3668763..3671309) Shigella dysenteriae Sd197 3797778 YP_405366.1 CDS hemC NC_007606.1 3671675 3672637 D hydroxymethylbilane synthase; transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 3671675..3672637 Shigella dysenteriae Sd197 3797779 YP_405367.1 CDS hemD NC_007606.1 3672634 3673374 D catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 3672634..3673374 Shigella dysenteriae Sd197 3797780 YP_405368.1 CDS hemX NC_007606.1 3673396 3674577 D Code: H; COG: COG2959; uroporphyrinogen III C-methyltransferase 3673396..3674577 Shigella dysenteriae Sd197 3797781 YP_405369.1 CDS hemY NC_007606.1 3674580 3675776 D Code: H; COG: COG3071; protoheme IX biogenesis protein 3674580..3675776 Shigella dysenteriae Sd197 3797782 YP_405370.1 CDS aslA NC_007606.1 3676454 3678109 D Code: P; COG: COG3119; arylsulfatase 3676454..3678109 Shigella dysenteriae Sd197 3797783 YP_009000845.1 CDS SDY_4773 NC_007606.1 3679015 3679287 D insertion element iso-IS1N protein InsA 3679015..3679287 Shigella dysenteriae Sd197 18263159 YP_405371.1 CDS SDY_3946 NC_007606.1 3679314 3679709 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3679314..3679709 Shigella dysenteriae Sd197 3797784 YP_405372.1 CDS yifK NC_007606.1 3680972 3682357 R uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transport protein YifK complement(3680972..3682357) Shigella dysenteriae Sd197 3797449 YP_405373.1 CDS wecG NC_007606.1 3682548 3683288 R synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG1922; UDP-N-acetyl-D-mannosaminuronic acid transferase complement(3682548..3683288) Shigella dysenteriae Sd197 3797450 YP_405374.1 CDS wecF NC_007606.1 3683291 3684643 R synthesis of enterobacterial common antigen (ECA); enterobacterial common antigen polymerase; common antigen polymerase complement(3683291..3684643) Shigella dysenteriae Sd197 3797451 YP_405375.1 CDS yifM NC_007606.1 3684640 3685719 R catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase complement(3684640..3685719) Shigella dysenteriae Sd197 3797452 YP_405376.1 CDS wzxE NC_007606.1 3685716 3686966 R Code: R; COG: COG2244; cytochrome complement(3685716..3686966) Shigella dysenteriae Sd197 3797453 YP_405377.1 CDS wecE NC_007606.1 3686968 3688098 R catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase complement(3686968..3688098) Shigella dysenteriae Sd197 3797454 YP_405378.1 CDS wecD NC_007606.1 3688103 3688648 R Code: KR; COG: COG0454; TDP-fucosamine acetyltransferase complement(3688103..3688648) Shigella dysenteriae Sd197 3797455 YP_405379.1 CDS rffH NC_007606.1 3688755 3689636 R Code: M; COG: COG1209; glucose-1-phosphate thymidylyltransferase complement(3688755..3689636) Shigella dysenteriae Sd197 3797456 YP_405380.1 CDS wecC NC_007606.1 3690630 3691892 R synthesis of enterobacterial common antigen (ECA); catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase complement(3690630..3691892) Shigella dysenteriae Sd197 3797458 YP_405381.1 CDS wecB NC_007606.1 3691889 3693061 R synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG0381; UDP-N-acetyl glucosamine -2-epimerase complement(3691889..3693061) Shigella dysenteriae Sd197 3797459 YP_405382.1 CDS wzzE NC_007606.1 3693075 3694124 R Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE complement(3693075..3694124) Shigella dysenteriae Sd197 3797460 YP_405383.1 CDS rfe NC_007606.1 3694133 3695236 R synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG0472; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase complement(3694133..3695236) Shigella dysenteriae Sd197 3797709 YP_405384.1 CDS SDY_3965 NC_007606.1 3695248 3695466 R hypothetical protein complement(3695248..3695466) Shigella dysenteriae Sd197 3797710 YP_405385.1 CDS rho NC_007606.1 3695476 3696735 R polarity suppressor; An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho complement(3695476..3696735) Shigella dysenteriae Sd197 3797711 YP_405386.1 CDS rhoL NC_007606.1 3696820 3696921 R rho operon leader peptide complement(3696820..3696921) Shigella dysenteriae Sd197 3797712 YP_405387.1 CDS trxA NC_007606.1 3697062 3697445 R Code: OC; COG: COG0526; thioredoxin complement(3697062..3697445) Shigella dysenteriae Sd197 3797713 YP_405388.1 CDS rhlB NC_007606.1 3697522 3698787 D ''enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation''; ATP-dependent RNA helicase RhlB 3697522..3698787 Shigella dysenteriae Sd197 3797714 YP_405389.1 CDS gppA NC_007606.1 3698921 3700405 D exopolyphosphatase; ''catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation''; guanosine pentaphosphate phosphohydrolase 3698921..3700405 Shigella dysenteriae Sd197 3797715 YP_405390.1 CDS rep NC_007606.1 3700452 3702473 R a single-stranded DNA dependent ATPase; single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep complement(3700452..3702473) Shigella dysenteriae Sd197 3797716 YP_405391.2 CDS SDY_3972 NC_007606.1 3703253 3704158 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3703253..3704158 Shigella dysenteriae Sd197 3797717 YP_009000846.1 CDS SDY_3972a NC_007606.1 3704165 3704476 D hypothetical protein 3704165..3704476 Shigella dysenteriae Sd197 18263160 YP_405392.1 CDS ppiC NC_007606.1 3704675 3704956 D rotamase C; Code: O; COG: COG0760; peptidyl-prolyl cis-trans isomerase C 3704675..3704956 Shigella dysenteriae Sd197 3797718 YP_405393.1 CDS ilvC NC_007606.1 3705002 3706477 R ''catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis''; ketol-acid reductoisomerase complement(3705002..3706477) Shigella dysenteriae Sd197 3797719 YP_405394.2 CDS ilvY NC_007606.1 3706627 3707517 D participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 3706627..3707517 Shigella dysenteriae Sd197 3797720 YP_405395.1 CDS ilvA NC_007606.1 3707514 3709058 R dehydratase; ''threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway''; threonine dehydratase complement(3707514..3709058) Shigella dysenteriae Sd197 3797721 YP_405396.1 CDS ilvD NC_007606.1 3709061 3710911 R ''catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis''; dihydroxy-acid dehydratase complement(3709061..3710911) Shigella dysenteriae Sd197 3797722 YP_405397.1 CDS ilvE NC_007606.1 3710976 3711905 R catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase complement(3710976..3711905) Shigella dysenteriae Sd197 3797723 YP_405398.1 CDS ilvM NC_007606.1 3711925 3712188 R Code: S; COG: COG3978; acetolactate synthase 2 regulatory subunit complement(3711925..3712188) Shigella dysenteriae Sd197 3797724 YP_405399.1 CDS ilvG NC_007606.1 3712185 3713831 R catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit complement(3712185..3713831) Shigella dysenteriae Sd197 3797725 YP_405400.1 CDS ilvL NC_007606.1 3713971 3714069 R ilvG operon leader peptide complement(3713971..3714069) Shigella dysenteriae Sd197 3797726 YP_405401.1 CDS SDY_3983 NC_007606.1 3715802 3716998 D Code: L; COG: COG3547; insertion element IS110 transposase 3715802..3716998 Shigella dysenteriae Sd197 3797728 YP_405402.1 CDS yifE NC_007606.1 3717404 3717742 R Code: S; COG: COG3085; hypothetical protein complement(3717404..3717742) Shigella dysenteriae Sd197 3798008 YP_405403.1 CDS yifDA NC_007606.1 3717861 3718700 D Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 3717861..3718700 Shigella dysenteriae Sd197 3798009 YP_405404.1 CDS yieP NC_007606.1 3724491 3725183 D Code: K; COG: COG2186; hypothetical protein 3724491..3725183 Shigella dysenteriae Sd197 3798016 YP_405405.1 CDS yieO NC_007606.1 3725206 3726633 D Code: GEPR; COG: COG0477; transport protein 3725206..3726633 Shigella dysenteriae Sd197 3798017 YP_405406.1 CDS rbsR NC_007606.1 3726641 3727591 R DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR complement(3726641..3727591) Shigella dysenteriae Sd197 3798018 YP_405407.1 CDS rbsK NC_007606.1 3727595 3728524 R catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase complement(3727595..3728524) Shigella dysenteriae Sd197 3798019 YP_405408.1 CDS rbsC NC_007606.1 3729561 3730526 R functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease complement(3729561..3730526) Shigella dysenteriae Sd197 3797670 YP_405409.1 CDS SDY_3998 NC_007606.1 3730634 3731029 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3730634..3731029) Shigella dysenteriae Sd197 3797671 YP_009000847.1 CDS SDY_4774 NC_007606.1 3731056 3731328 R insertion element iso-IS1N protein InsA complement(3731056..3731328) Shigella dysenteriae Sd197 18263161 YP_405410.1 CDS trkD NC_007606.1 3733404 3735278 R Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup complement(3733404..3735278) Shigella dysenteriae Sd197 3797674 YP_405411.2 CDS yieN NC_007606.1 3735501 3736997 D ''interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase''; regulatory ATPase RavA 3735501..3736997 Shigella dysenteriae Sd197 3797675 YP_405412.1 CDS yieM NC_007606.1 3736991 3738442 D contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 3736991..3738442 Shigella dysenteriae Sd197 3797676 YP_405413.1 CDS asnA NC_007606.1 3738447 3739439 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(3738447..3739439) Shigella dysenteriae Sd197 3797677 YP_405414.1 CDS asnC NC_007606.1 3739591 3740049 D transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 3739591..3740049 Shigella dysenteriae Sd197 3797678 YP_405415.1 CDS mioC NC_007606.1 3740139 3740582 D ''An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group''; flavodoxin 3740139..3740582 Shigella dysenteriae Sd197 3797679 YP_405416.1 CDS gidA NC_007606.1 3740961 3742850 D possibly involved in chromosome replication; GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 3740961..3742850 Shigella dysenteriae Sd197 3797680 YP_405417.1 CDS gidB NC_007606.1 3742914 3743537 D possibly involved in chromosome replication; glucose-inhibited division; glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 3742914..3743537 Shigella dysenteriae Sd197 3797681 YP_405418.2 CDS atpI NC_007606.1 3744154 3744534 D dispensable protein; affects expression of atpB; Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 3744154..3744534 Shigella dysenteriae Sd197 3797682 YP_405419.1 CDS atpB NC_007606.1 3744543 3745358 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 3744543..3745358 Shigella dysenteriae Sd197 3797683 YP_405420.1 CDS atpE NC_007606.1 3745405 3745644 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 3745405..3745644 Shigella dysenteriae Sd197 3797684 YP_405421.1 CDS atpF NC_007606.1 3745706 3746176 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 3745706..3746176 Shigella dysenteriae Sd197 3797685 YP_405422.1 CDS atpH NC_007606.1 3746191 3746724 D Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 3746191..3746724 Shigella dysenteriae Sd197 3797686 YP_405423.1 CDS atpA NC_007606.1 3746737 3748278 D produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 3746737..3748278 Shigella dysenteriae Sd197 3797687 YP_405424.1 CDS atpG NC_007606.1 3748329 3749192 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 3748329..3749192 Shigella dysenteriae Sd197 3797688 YP_405425.1 CDS atpD NC_007606.1 3749219 3750601 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 3749219..3750601 Shigella dysenteriae Sd197 3797689 YP_405426.1 CDS atpC NC_007606.1 3750622 3751041 D part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 3750622..3751041 Shigella dysenteriae Sd197 3796862 YP_405427.1 CDS glmU NC_007606.1 3751393 3752763 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 3751393..3752763 Shigella dysenteriae Sd197 3796863 YP_405428.1 CDS glmS NC_007606.1 3752925 3754754 D ''Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source''; glucosamine--fructose-6-phosphate aminotransferase 3752925..3754754 Shigella dysenteriae Sd197 3796864 YP_405429.1 CDS SDY_4020 NC_007606.1 3755155 3756363 R insertion sequence element IS1294 transposase complement(3755155..3756363) Shigella dysenteriae Sd197 3796865 YP_405430.1 CDS SDY_4021 NC_007606.1 3756344 3756616 R hypothetical protein complement(3756344..3756616) Shigella dysenteriae Sd197 3796866 YP_405431.1 CDS pstS NC_007606.1 3756878 3757918 D periplasmic phosphate-binding protein; Code: P; COG: COG0226; phosphate ABC transporter substrate-binding protein 3756878..3757918 Shigella dysenteriae Sd197 3796867 YP_405432.1 CDS pstC NC_007606.1 3758004 3759005 D part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease PstC 3758004..3759005 Shigella dysenteriae Sd197 3796868 YP_405433.1 CDS pstA NC_007606.1 3759005 3759895 D Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease PtsA 3759005..3759895 Shigella dysenteriae Sd197 3796869 YP_405434.1 CDS pstB NC_007606.1 3760078 3760851 D Code: P; COG: COG1117; phosphate transporter subunit 3760078..3760851 Shigella dysenteriae Sd197 3796870 YP_405435.1 CDS phoU NC_007606.1 3760866 3761591 D enzyme in phosphate metabolism; regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 3760866..3761591 Shigella dysenteriae Sd197 3796871 YP_405436.1 CDS SDY_4027 NC_007606.1 3762014 3763675 D hypothetical protein 3762014..3763675 Shigella dysenteriae Sd197 3796872 YP_405437.1 CDS SDY_4028 NC_007606.1 3763990 3764493 D hypothetical protein 3763990..3764493 Shigella dysenteriae Sd197 3796873 YP_405438.1 CDS insA NC_007606.1 3764736 3765011 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3764736..3765011 Shigella dysenteriae Sd197 3796874 YP_405439.1 CDS insB NC_007606.1 3765056 3765433 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3765056..3765433 Shigella dysenteriae Sd197 3796875 YP_009000848.1 CDS SDY_4775 NC_007606.1 3766246 3766518 D insertion element iso-IS1N protein InsA 3766246..3766518 Shigella dysenteriae Sd197 18263162 YP_405442.1 CDS SDY_4033 NC_007606.1 3767585 3768784 D hypothetical protein 3767585..3768784 Shigella dysenteriae Sd197 3796878 YP_405443.1 CDS SDY_4034 NC_007606.1 3769333 3771840 D Code: UW; COG: COG5295; hypothetical protein 3769333..3771840 Shigella dysenteriae Sd197 3796879 YP_405444.1 CDS SDY_4035 NC_007606.1 3771929 3772765 D hypothetical protein 3771929..3772765 Shigella dysenteriae Sd197 3796880 YP_405445.1 CDS lldP NC_007606.1 3773192 3774847 D Code: C; COG: COG1620; L-lactate permease 3773192..3774847 Shigella dysenteriae Sd197 3795518 YP_405446.1 CDS lldR NC_007606.1 3774847 3775623 D represses the lctPRD operon; DNA-binding transcriptional repressor LldR 3774847..3775623 Shigella dysenteriae Sd197 3795519 YP_405447.1 CDS lldD NC_007606.1 3775620 3776810 D flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 3775620..3776810 Shigella dysenteriae Sd197 3795520 YP_405448.1 CDS yibK NC_007606.1 3776996 3777469 D member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 3776996..3777469 Shigella dysenteriae Sd197 3795521 YP_405449.1 CDS cysE NC_007606.1 3777522 3778343 R catalyzes the O-acetylation of serine; serine acetyltransferase complement(3777522..3778343) Shigella dysenteriae Sd197 3795522 YP_405450.1 CDS gpsA NC_007606.1 3778423 3779442 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(3778423..3779442) Shigella dysenteriae Sd197 3795523 YP_405451.1 CDS secB NC_007606.1 3779442 3779909 R protein export; molecular chaperone; may bind to signel sequence; molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB complement(3779442..3779909) Shigella dysenteriae Sd197 3795524 YP_405452.1 CDS grxC NC_007606.1 3779972 3780223 R Code: O; COG: COG0695; glutaredoxin 3 complement(3779972..3780223) Shigella dysenteriae Sd197 3795525 YP_405453.1 CDS yibN NC_007606.1 3780365 3780796 R Code: P; COG: COG0607; hypothetical protein complement(3780365..3780796) Shigella dysenteriae Sd197 3795526 YP_405454.1 CDS yibO NC_007606.1 3781041 3782585 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 3781041..3782585 Shigella dysenteriae Sd197 3795527 YP_405455.1 CDS yibP NC_007606.1 3782595 3783878 D Code: D; COG: COG4942; hypothetical protein 3782595..3783878 Shigella dysenteriae Sd197 3795528 YP_405456.1 CDS yibQ NC_007606.1 3784008 3784841 D Code: S; COG: COG2861; hypothetical protein 3784008..3784841 Shigella dysenteriae Sd197 3795529 YP_405457.1 CDS yibD NC_007606.1 3784847 3785851 R Code: M; COG: COG0463; glycosyl transferase complement(3784847..3785851) Shigella dysenteriae Sd197 3795530 YP_405458.1 CDS tdh NC_007606.1 3786090 3787115 R ''converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism''; L-threonine 3-dehydrogenase complement(3786090..3787115) Shigella dysenteriae Sd197 3795531 YP_405459.1 CDS kbl NC_007606.1 3787125 3788321 R glycine acetyltransferase; catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase complement(3787125..3788321) Shigella dysenteriae Sd197 3795532 YP_405460.1 CDS rfaD NC_007606.1 3788535 3789467 D catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 3788535..3789467 Shigella dysenteriae Sd197 3795533 YP_405461.1 CDS rfaF NC_007606.1 3789477 3790523 D lipopolysaccharide core biosynthesis; catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose--LPS heptosyltransferase 3789477..3790523 Shigella dysenteriae Sd197 3795534 YP_405462.1 CDS rfaC NC_007606.1 3790527 3791486 D lipopolysaccharide core biosynthesis; Code: M; COG: COG0859; ADP-heptose--LPS heptosyltransferase 3790527..3791486 Shigella dysenteriae Sd197 3795535 YP_405463.1 CDS waaL NC_007606.1 3791534 3792787 R lipid A-core:surface polymer ligase WaaL complement(3791534..3792787) Shigella dysenteriae Sd197 3795536 YP_405464.1 CDS waaX NC_007606.1 3792822 3793595 R Code: M; COG: COG3306; beta 1,4-galactosyltransferase WaaX complement(3792822..3793595) Shigella dysenteriae Sd197 3795537 YP_405465.1 CDS waaW NC_007606.1 3793627 3794655 R Code: M; COG: COG1442; UDP-galactose:(galactosyl) LPS alpha1,2-galactosyltransferase complement(3793627..3794655) Shigella dysenteriae Sd197 3795828 YP_405466.1 CDS rfaY NC_007606.1 3794681 3795373 R lipopolysaccharide core biosynthesis protein complement(3794681..3795373) Shigella dysenteriae Sd197 3795829 YP_405467.1 CDS rfaJ NC_007606.1 3795383 3796378 R Code: M; COG: COG1442; lipopolysaccharide 1,2-glucosyltransferase complement(3795383..3796378) Shigella dysenteriae Sd197 3795830 YP_405468.1 CDS rfaI NC_007606.1 3796395 3797411 R Code: M; COG: COG1442; lipopolysaccharide 1,3-galactosyltransferase complement(3796395..3797411) Shigella dysenteriae Sd197 3795831 YP_405469.1 CDS waaP NC_007606.1 3797427 3798233 R LPS biosynthesis protein complement(3797427..3798233) Shigella dysenteriae Sd197 3795832 YP_405470.1 CDS rfaG NC_007606.1 3798217 3799341 R lipopolysaccharide core biosynthesis; Code: M; COG: COG0438; glucosyltransferase I complement(3798217..3799341) Shigella dysenteriae Sd197 3795833 YP_405471.1 CDS waaQ NC_007606.1 3799338 3800396 R Code: M; COG: COG0859; lipopolysaccharide core biosynthesis protein complement(3799338..3800396) Shigella dysenteriae Sd197 3795834 YP_405472.1 CDS kdtA NC_007606.1 3800809 3802086 D KDO transferase; catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 3800809..3802086 Shigella dysenteriae Sd197 3795835 YP_405473.1 CDS coaD NC_007606.1 3802094 3802573 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 3802094..3802573 Shigella dysenteriae Sd197 3795836 YP_405474.1 CDS mutM NC_007606.1 3802612 3803421 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(3802612..3803421) Shigella dysenteriae Sd197 3795837 YP_405475.1 CDS rpmG NC_007606.1 3803519 3803686 R ''in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif''; 50S ribosomal protein L33 complement(3803519..3803686) Shigella dysenteriae Sd197 3795838 YP_405476.1 CDS rpmB NC_007606.1 3803707 3803943 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(3803707..3803943) Shigella dysenteriae Sd197 3795839 YP_405477.1 CDS radC NC_007606.1 3804160 3804834 R Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC complement(3804160..3804834) Shigella dysenteriae Sd197 3795840 YP_405478.2 CDS dfp NC_007606.1 3805000 3806220 D flavoprotein affecting synthesis of DNA and pantothenate metabolism; ''catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine''; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 3805000..3806220 Shigella dysenteriae Sd197 3795841 YP_405479.1 CDS dut NC_007606.1 3806201 3806656 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 3806201..3806656 Shigella dysenteriae Sd197 3795842 YP_405480.2 CDS slmA NC_007606.1 3806763 3807359 D FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 3806763..3807359 Shigella dysenteriae Sd197 3795843 YP_405482.1 CDS pyrE NC_007606.1 3808651 3809292 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(3808651..3809292) Shigella dysenteriae Sd197 3795845 YP_405483.1 CDS rph NC_007606.1 3809358 3810074 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(3809358..3810074) Shigella dysenteriae Sd197 3795846 YP_405484.1 CDS yicC NC_007606.1 3810201 3811064 D Code: S; COG: COG1561; hypothetical protein 3810201..3811064 Shigella dysenteriae Sd197 3795749 YP_405485.2 CDS dinD NC_007606.1 3811284 3812108 D DNA-damage-inducible protein D 3811284..3812108 Shigella dysenteriae Sd197 3795750 YP_405486.1 CDS yicG NC_007606.1 3812346 3813017 D Code: S; COG: COG2860; hypothetical protein 3812346..3813017 Shigella dysenteriae Sd197 3795751 YP_405488.1 CDS gmk NC_007606.1 3814950 3815573 D ''Essential for recycling GMP and indirectly, cGMP''; guanylate kinase 3814950..3815573 Shigella dysenteriae Sd197 3795754 YP_405489.1 CDS rpoZ NC_007606.1 3815628 3815903 D promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 3815628..3815903 Shigella dysenteriae Sd197 3795755 YP_405490.1 CDS spoT NC_007606.1 3815922 3818030 D also guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Code: TK; COG: COG0317; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 3815922..3818030 Shigella dysenteriae Sd197 3795756 YP_405491.1 CDS spoU NC_007606.1 3818037 3818726 D specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 3818037..3818726 Shigella dysenteriae Sd197 3795757 YP_405492.1 CDS recG NC_007606.1 3818732 3820813 D resolution of Holliday junctions; branch migration; catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 3818732..3820813 Shigella dysenteriae Sd197 3795758 YP_405493.1 CDS gltS NC_007606.1 3820989 3822194 R Code: E; COG: COG0786; glutamate transport complement(3820989..3822194) Shigella dysenteriae Sd197 3795759 YP_405494.1 CDS yicE NC_007606.1 3822473 3823864 D Code: F; COG: COG2233; transport protein 3822473..3823864 Shigella dysenteriae Sd197 3795760 YP_405495.1 CDS yicH NC_007606.1 3823985 3825694 D hypothetical protein 3823985..3825694 Shigella dysenteriae Sd197 3795761 YP_405496.1 CDS SDY_4089 NC_007606.1 3826217 3826519 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 3826217..3826519 Shigella dysenteriae Sd197 3795763 YP_405498.1 CDS melA NC_007606.1 3828164 3829519 R Code: G; COG: COG1486; alpha-galactosidase complement(3828164..3829519) Shigella dysenteriae Sd197 3795766 YP_405499.1 CDS adiA NC_007606.1 3830790 3833060 D Code: E; COG: COG1982; biodegradative arginine decarboxylase 3830790..3833060 Shigella dysenteriae Sd197 3795768 YP_405500.1 CDS insA NC_007606.1 3833180 3833455 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3833180..3833455 Shigella dysenteriae Sd197 3799421 YP_405501.1 CDS insB NC_007606.1 3833500 3833877 D Code: L; COG: COG1662; insertion sequence element IS1 transposase 3833500..3833877 Shigella dysenteriae Sd197 3799422 YP_405502.1 CDS adiY NC_007606.1 3834162 3834923 D Code: K; COG: COG2207; AraC family transcriptional regulator 3834162..3834923 Shigella dysenteriae Sd197 3799423 YP_405503.1 CDS yjdE NC_007606.1 3835060 3836397 D Code: E; COG: COG0531; arginine:agmatin antiporter 3835060..3836397 Shigella dysenteriae Sd197 3799424 YP_405504.1 CDS yjdB NC_007606.1 3836456 3838144 D with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein 3836456..3838144 Shigella dysenteriae Sd197 3799425 YP_405505.1 CDS basS NC_007606.1 3838799 3839890 D Code: T; COG: COG0642; sensor protein BasS/PmrB 3838799..3839890 Shigella dysenteriae Sd197 3799427 YP_405506.1 CDS proP NC_007606.1 3840067 3841569 R low-affinity transport system; Code: GEPR; COG: COG0477; proline/glycine betaine transporter complement(3840067..3841569) Shigella dysenteriae Sd197 3799428 YP_405507.1 CDS yjcZ NC_007606.1 3841833 3842678 R hypothetical protein complement(3841833..3842678) Shigella dysenteriae Sd197 3799429 YP_405508.1 CDS insA NC_007606.1 3844513 3844788 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3844513..3844788 Shigella dysenteriae Sd197 3799430 YP_405509.1 CDS insB NC_007606.1 3844833 3845210 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3844833..3845210 Shigella dysenteriae Sd197 3799431 YP_405510.1 CDS insB NC_007606.1 3845798 3846175 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(3845798..3846175) Shigella dysenteriae Sd197 3799433 YP_405511.1 CDS insA NC_007606.1 3846220 3846495 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3846220..3846495) Shigella dysenteriae Sd197 3799434 YP_405512.1 CDS phnA NC_007606.1 3846892 3847227 D Code: P; COG: COG2824; hypothetical protein 3846892..3847227 Shigella dysenteriae Sd197 3799435 YP_405513.1 CDS phnC NC_007606.1 3847963 3848751 D Code: P; COG: COG3638; phosphonate/organophosphate ester ABC transporter ATP-binding protein 3847963..3848751 Shigella dysenteriae Sd197 3799437 YP_405514.1 CDS phnD NC_007606.1 3848776 3849792 D Code: P; COG: COG3221; phosphonate/organophosphate ester ABC transporter substrate-binding protein 3848776..3849792 Shigella dysenteriae Sd197 3799438 YP_405515.1 CDS phnE NC_007606.1 3849847 3850677 D Code: P; COG: COG3639; phosphonate/organophosphate ester ABC transporter permease 3849847..3850677 Shigella dysenteriae Sd197 3799439 YP_405516.1 CDS phnF NC_007606.1 3850698 3851423 D may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF 3850698..3851423 Shigella dysenteriae Sd197 3798881 YP_405517.1 CDS phnH NC_007606.1 3851860 3852444 D Code: P; COG: COG3625; carbon-phosphorus lyase complex subunit 3851860..3852444 Shigella dysenteriae Sd197 3798883 YP_405518.1 CDS phnI NC_007606.1 3852444 3853508 D Code: P; COG: COG3626; phosphonate metabolism protein 3852444..3853508 Shigella dysenteriae Sd197 3798884 YP_405519.1 CDS phnJ NC_007606.1 3853501 3854346 D Code: P; COG: COG3627; phosphonate metabolism protein 3853501..3854346 Shigella dysenteriae Sd197 3798885 YP_405520.1 CDS phnK NC_007606.1 3854343 3855101 D Code: P; COG: COG4107; phosphonate C-P lyase system protein PhnK 3854343..3855101 Shigella dysenteriae Sd197 3798886 YP_405521.1 CDS phnL NC_007606.1 3855212 3855892 D Code: P; COG: COG4778; phosphonate ABC transporter ATP-binding protein 3855212..3855892 Shigella dysenteriae Sd197 3798887 YP_405522.1 CDS phnM NC_007606.1 3855889 3856941 D Code: P; COG: COG3454; phosphonate metabolism protein 3855889..3856941 Shigella dysenteriae Sd197 3798888 YP_405523.1 CDS phnN NC_007606.1 3856941 3857498 D Code: P; COG: COG3709; ribose 1,5-bisphosphokinase 3856941..3857498 Shigella dysenteriae Sd197 3798889 YP_405524.1 CDS phnO NC_007606.1 3857485 3857919 D PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase 3857485..3857919 Shigella dysenteriae Sd197 3798890 YP_405525.1 CDS phnP NC_007606.1 3857921 3858679 D required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein 3857921..3858679 Shigella dysenteriae Sd197 3798891 YP_405526.1 CDS SDY_4125 NC_007606.1 3858756 3859085 R hypothetical protein complement(3858756..3859085) Shigella dysenteriae Sd197 3798892 YP_405527.1 CDS SDY_4126 NC_007606.1 3859154 3859909 R hypothetical protein complement(3859154..3859909) Shigella dysenteriae Sd197 3798893 YP_405528.1 CDS SDY_4127 NC_007606.1 3859899 3862163 R Code: T; COG: COG0642; histidine kinase complement(3859899..3862163) Shigella dysenteriae Sd197 3798894 YP_405529.1 CDS SDY_4128 NC_007606.1 3862277 3863764 D Code: G; COG: COG1129; ribose ABC transporter ATP-binding protein 3862277..3863764 Shigella dysenteriae Sd197 3798895 YP_405531.1 CDS SDY_4130 NC_007606.1 3864769 3865710 D Code: G; COG: COG1879; ribose ABC transporter substrate-binding protein 3864769..3865710 Shigella dysenteriae Sd197 3798897 YP_405532.1 CDS SDY_4131 NC_007606.1 3865765 3866448 D Code: R; COG: COG3822; hypothetical protein 3865765..3866448 Shigella dysenteriae Sd197 3798898 YP_405533.1 CDS SDY_4132 NC_007606.1 3866463 3867323 D Code: G; COG: COG0191; hypothetical protein 3866463..3867323 Shigella dysenteriae Sd197 3798899 YP_405534.1 CDS SDY_4133 NC_007606.1 3867320 3868321 D Code: G; COG: COG0524; kinase 3867320..3868321 Shigella dysenteriae Sd197 3798900 YP_405535.1 CDS SDY_4134 NC_007606.1 3868318 3869043 R Code: TK; COG: COG0745; transcriptional regulator complement(3868318..3869043) Shigella dysenteriae Sd197 3797218 YP_405536.1 CDS SDY_4135 NC_007606.1 3869067 3869462 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3869067..3869462) Shigella dysenteriae Sd197 3797219 YP_009000849.1 CDS SDY_4776 NC_007606.1 3869489 3869761 R insertion element iso-IS1N protein InsA complement(3869489..3869761) Shigella dysenteriae Sd197 18263163 YP_405537.1 CDS SDY_4136 NC_007606.1 3869814 3870608 R hypothetical protein complement(3869814..3870608) Shigella dysenteriae Sd197 3797220 YP_405538.1 CDS SDY_4137 NC_007606.1 3870707 3872221 R hypothetical protein complement(3870707..3872221) Shigella dysenteriae Sd197 3797221 YP_405540.1 CDS insA NC_007606.1 3872967 3873242 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3872967..3873242 Shigella dysenteriae Sd197 3797223 YP_405541.1 CDS insB NC_007606.1 3873287 3873664 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3873287..3873664 Shigella dysenteriae Sd197 3797224 YP_405542.2 CDS yicM NC_007606.1 3873880 3875064 R Code: G; COG: COG2814; transport protein complement(3873880..3875064) Shigella dysenteriae Sd197 3797225 YP_405543.1 CDS SDY_4142 NC_007606.1 3875292 3875651 D Code: S; COG: COG4737; hypothetical protein 3875292..3875651 Shigella dysenteriae Sd197 3797226 YP_405544.1 CDS SDY_4143 NC_007606.1 3875635 3875958 D Code: K; COG: COG2944; DNA-binding protein 3875635..3875958 Shigella dysenteriae Sd197 3797227 YP_405545.1 CDS yicN NC_007606.1 3876073 3876552 R hypothetical protein complement(3876073..3876552) Shigella dysenteriae Sd197 3797228 YP_405546.1 CDS yicP NC_007606.1 3878058 3879812 D catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 3878058..3879812 Shigella dysenteriae Sd197 3797230 YP_405547.1 CDS uhpT NC_007606.1 3879856 3881247 R cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter complement(3879856..3881247) Shigella dysenteriae Sd197 3797231 YP_405548.1 CDS uhpC NC_007606.1 3881385 3882707 R membrane protein regulates uhpT expression; regulatory protein UhpC complement(3881385..3882707) Shigella dysenteriae Sd197 3797232 YP_405549.1 CDS uhpB NC_007606.1 3882714 3884219 R Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB complement(3882714..3884219) Shigella dysenteriae Sd197 3797233 YP_405550.1 CDS uhpA NC_007606.1 3884216 3884806 R sensor, uhpB; ''response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter''; DNA-binding transcriptional activator UhpA complement(3884216..3884806) Shigella dysenteriae Sd197 3797234 YP_405551.1 CDS SDY_4151 NC_007606.1 3885501 3885896 D Code: L; COG: COG1662; insertion element IS1 protein InsB 3885501..3885896 Shigella dysenteriae Sd197 3797235 YP_405552.1 CDS SDY_4152 NC_007606.1 3886743 3887138 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3886743..3887138) Shigella dysenteriae Sd197 3797236 YP_009000850.1 CDS SDY_4777 NC_007606.1 3887165 3887437 R insertion element iso-IS1N protein InsA complement(3887165..3887437) Shigella dysenteriae Sd197 18263164 YP_405554.1 CDS ilvN NC_007606.1 3888603 3888893 R ''with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit''; acetolactate synthase 1 regulatory subunit complement(3888603..3888893) Shigella dysenteriae Sd197 3799171 YP_405555.1 CDS ilvB NC_007606.1 3888897 3890585 R Code: EH; COG: COG0028; acetolactate synthase catalytic subunit complement(3888897..3890585) Shigella dysenteriae Sd197 3799172 YP_405556.1 CDS ivbL NC_007606.1 3890691 3890789 R ilvB operon leader peptide complement(3890691..3890789) Shigella dysenteriae Sd197 3799173 YP_405557.1 CDS emrD NC_007606.1 3891717 3892907 D multidrug resistance; multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 3891717..3892907 Shigella dysenteriae Sd197 3799174 YP_405558.1 CDS yidF NC_007606.1 3892915 3893412 R Code: R; COG: COG0641; transcriptional regulator complement(3892915..3893412) Shigella dysenteriae Sd197 3799175 YP_405559.1 CDS yidG NC_007606.1 3893409 3893771 R hypothetical protein complement(3893409..3893771) Shigella dysenteriae Sd197 3799176 YP_405560.1 CDS yidH NC_007606.1 3893761 3894108 R Code: S; COG: COG2149; hypothetical protein complement(3893761..3894108) Shigella dysenteriae Sd197 3799177 YP_405561.1 CDS yidI NC_007606.1 3894218 3894667 D hypothetical protein 3894218..3894667 Shigella dysenteriae Sd197 3799178 YP_405562.1 CDS yidJ NC_007606.1 3894714 3896207 R Code: P; COG: COG3119; sulfatase complement(3894714..3896207) Shigella dysenteriae Sd197 3799179 YP_405563.1 CDS insB NC_007606.1 3897171 3897548 R Code: L; COG: COG1662; insertion sequence element IS1 transposase complement(3897171..3897548) Shigella dysenteriae Sd197 3799180 YP_405564.1 CDS insA NC_007606.1 3897593 3897868 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3897593..3897868) Shigella dysenteriae Sd197 3799181 YP_009000851.1 CDS SDY_4778 NC_007606.1 3899435 3899707 D insertion element iso-IS1N protein InsA 3899435..3899707 Shigella dysenteriae Sd197 18263165 YP_405565.1 CDS SDY_4167 NC_007606.1 3899734 3900129 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3899734..3900129 Shigella dysenteriae Sd197 3799184 YP_405566.1 CDS SDY_4168 NC_007606.1 3900527 3901849 R Code: G; COG: COG1486; 6-phospho-beta-glucosidase complement(3900527..3901849) Shigella dysenteriae Sd197 3799185 YP_405567.1 CDS yidP NC_007606.1 3903761 3904477 D Code: K; COG: COG2188; transcriptional regulator 3903761..3904477 Shigella dysenteriae Sd197 3799187 YP_405568.2 CDS yidE NC_007606.1 3904474 3906135 R Code: R; COG: COG2985; hypothetical protein complement(3904474..3906135) Shigella dysenteriae Sd197 3799188 YP_405569.2 CDS ibpB NC_007606.1 3906331 3906759 R ''16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent''; heat shock chaperone IbpB complement(3906331..3906759) Shigella dysenteriae Sd197 3799189 YP_405570.1 CDS ibpA NC_007606.1 3906871 3907284 R with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA complement(3906871..3907284) Shigella dysenteriae Sd197 3799825 YP_405571.2 CDS yidQ NC_007606.1 3907590 3907922 D Code: R; COG: COG5645; hypothetical protein 3907590..3907922 Shigella dysenteriae Sd197 3799826 YP_405572.1 CDS yidR NC_007606.1 3907924 3909168 R hypothetical protein complement(3907924..3909168) Shigella dysenteriae Sd197 3799827 YP_405573.2 CDS yidS NC_007606.1 3909233 3910297 D FAD/NAD(P)-binding domain; oxidoreductase 3909233..3910297 Shigella dysenteriae Sd197 3799828 YP_009000852.1 CDS SDY_4779 NC_007606.1 3911091 3911363 D insertion element iso-IS1N protein InsA 3911091..3911363 Shigella dysenteriae Sd197 18263166 YP_405575.1 CDS yidA NC_007606.1 3912019 3912831 R ''YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins''; sugar phosphatase complement(3912019..3912831) Shigella dysenteriae Sd197 3799831 YP_405576.1 CDS yidB NC_007606.1 3912946 3913344 R Code: S; COG: COG3753; hypothetical protein complement(3912946..3913344) Shigella dysenteriae Sd197 3799832 YP_405577.1 CDS gyrB NC_007606.1 3913584 3915998 R type II topoisomerase; ATPase activity; negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(3913584..3915998) Shigella dysenteriae Sd197 3799833 YP_405578.1 CDS recF NC_007606.1 3916027 3917100 R ''Required for DNA replication; binds preferentially to single-stranded, linear DNA''; recombination protein F complement(3916027..3917100) Shigella dysenteriae Sd197 3799834 YP_405579.1 CDS dnaN NC_007606.1 3917100 3918200 R binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta complement(3917100..3918200) Shigella dysenteriae Sd197 3799835 YP_405580.1 CDS dnaA NC_007606.1 3918205 3919608 R DNA biosynthesis; initiation of chromosome replication; can be transcription regulator; binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself; chromosome replication initiator DnaA complement(3918205..3919608) Shigella dysenteriae Sd197 3799836 YP_405581.1 CDS rpmH NC_007606.1 3920215 3920355 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 3920215..3920355 Shigella dysenteriae Sd197 3799837 YP_405582.1 CDS rnpA NC_007606.1 3920372 3920731 D protein C5; processes tRNA, 4.5S RNA; protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 3920372..3920731 Shigella dysenteriae Sd197 3799838 YP_405583.1 CDS yidD NC_007606.1 3920695 3920952 D Code: S; COG: COG0759; hypothetical protein 3920695..3920952 Shigella dysenteriae Sd197 3799839 YP_405584.1 CDS yidC NC_007606.1 3920955 3922601 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 3920955..3922601 Shigella dysenteriae Sd197 3799840 YP_405585.1 CDS trmE NC_007606.1 3922707 3924071 D thiophene and furan oxidation; ''in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE''; tRNA modification GTPase TrmE 3922707..3924071 Shigella dysenteriae Sd197 3799841 YP_405586.1 CDS SDY_4190 NC_007606.1 3924317 3924712 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(3924317..3924712) Shigella dysenteriae Sd197 3799842 YP_009000853.1 CDS SDY_4780 NC_007606.1 3924739 3925011 R insertion element iso-IS1N protein InsA complement(3924739..3925011) Shigella dysenteriae Sd197 18263167 YP_405588.1 CDS insB NC_007606.1 3925682 3926059 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(3925682..3926059) Shigella dysenteriae Sd197 3798021 YP_405589.1 CDS insA NC_007606.1 3926104 3926379 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3926104..3926379) Shigella dysenteriae Sd197 3798022 YP_405591.1 CDS SDY_4195 NC_007606.1 3927304 3927606 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(3927304..3927606) Shigella dysenteriae Sd197 3798024 YP_405592.1 CDS insA NC_007606.1 3927700 3927975 D Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 3927700..3927975 Shigella dysenteriae Sd197 3798025 YP_405593.1 CDS insB NC_007606.1 3928020 3928397 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3928020..3928397 Shigella dysenteriae Sd197 3798026 YP_405594.1 CDS yieH NC_007606.1 3928581 3929246 R ''YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily''; 6-phosphogluconate phosphatase complement(3928581..3929246) Shigella dysenteriae Sd197 3798027 YP_405595.1 CDS yieG NC_007606.1 3929413 3930750 D Code: R; COG: COG2252; membrane/transport protein 3929413..3930750 Shigella dysenteriae Sd197 3798028 YP_405596.1 CDS yieE NC_007606.1 3931392 3932153 R Code: H; COG: COG2091; hypothetical protein complement(3931392..3932153) Shigella dysenteriae Sd197 3798030 YP_405597.1 CDS yidZ NC_007606.1 3932298 3933257 R Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ complement(3932298..3933257) Shigella dysenteriae Sd197 3798031 YP_405598.1 CDS yidY NC_007606.1 3933232 3934407 R Confers resistance to chloramphenicol; multidrug efflux system protein MdtL complement(3933232..3934407) Shigella dysenteriae Sd197 3798032 YP_405599.1 CDS tnaB NC_007606.1 3934539 3935726 R Code: E; COG: COG0814; low affinity tryptophan permease complement(3934539..3935726) Shigella dysenteriae Sd197 3798033 YP_405600.2 CDS SDY_4205 NC_007606.1 3935701 3936606 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(3935701..3936606) Shigella dysenteriae Sd197 3798034 YP_405601.1 CDS SDY_4207 NC_007606.1 3936564 3936929 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(3936564..3936929) Shigella dysenteriae Sd197 3798036 YP_009000854.1 CDS SDY_4781 NC_007606.1 3937190 3937462 D insertion element iso-IS1N protein InsA 3937190..3937462 Shigella dysenteriae Sd197 18263168 YP_405604.1 CDS SDY_4209 NC_007606.1 3937489 3937884 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3937489..3937884 Shigella dysenteriae Sd197 3798038 YP_405605.1 CDS rhsA NC_007606.1 3937859 3941500 R Code: M; COG: COG3209; rhs element protein RhsA complement(3937859..3941500) Shigella dysenteriae Sd197 3798039 YP_405606.1 CDS yibF NC_007606.1 3941729 3942337 D Code: O; COG: COG0625; glutathione S-transferase 3941729..3942337 Shigella dysenteriae Sd197 3798040 YP_405607.1 CDS selA NC_007606.1 3942435 3943826 D L-seryl-tRNA (Ser) selenium transferase; catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 3942435..3943826 Shigella dysenteriae Sd197 3797256 YP_405608.1 CDS selB NC_007606.1 3943823 3945667 D Code: J; COG: COG3276; selenocysteinyl-tRNA-specific translation factor 3943823..3945667 Shigella dysenteriae Sd197 3797257 YP_009000855.1 CDS SDY_4782 NC_007606.1 3945769 3946041 D insertion element iso-IS1N protein InsA 3945769..3946041 Shigella dysenteriae Sd197 18263169 YP_405610.1 CDS insA NC_007606.1 3947361 3947636 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3947361..3947636 Shigella dysenteriae Sd197 3797259 YP_405611.1 CDS insB NC_007606.1 3947681 3948058 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3947681..3948058 Shigella dysenteriae Sd197 3797260 YP_405612.1 CDS yjbA NC_007606.1 3950183 3950593 R Code: S; COG: COG3223; phosphate-starvation-inducible protein PsiE complement(3950183..3950593) Shigella dysenteriae Sd197 3797262 YP_405613.1 CDS yjbG NC_007606.1 3953184 3953921 R hypothetical protein complement(3953184..3953921) Shigella dysenteriae Sd197 3797264 YP_405614.1 CDS yjbF NC_007606.1 3953918 3954586 R hypothetical protein complement(3953918..3954586) Shigella dysenteriae Sd197 3797265 YP_405615.1 CDS yjbE NC_007606.1 3954670 3954912 R hypothetical protein complement(3954670..3954912) Shigella dysenteriae Sd197 3797266 YP_405616.1 CDS SDY_4223 NC_007606.1 3955296 3955691 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3955296..3955691) Shigella dysenteriae Sd197 3797267 YP_009000856.1 CDS SDY_4783 NC_007606.1 3955718 3955990 R insertion element iso-IS1N protein InsA complement(3955718..3955990) Shigella dysenteriae Sd197 18263170 YP_405618.1 CDS SDY_4225 NC_007606.1 3956304 3957512 D insertion sequence element IS1294 transposase 3956304..3957512 Shigella dysenteriae Sd197 3797269 YP_405619.1 CDS pgi NC_007606.1 3957906 3959555 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(3957906..3959555) Shigella dysenteriae Sd197 3797270 YP_405620.1 CDS lysC NC_007606.1 3960080 3961429 D lysine sensitive; catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase 3960080..3961429 Shigella dysenteriae Sd197 3797271 YP_405621.2 CDS SDY_4228 NC_007606.1 3961506 3962411 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(3961506..3962411) Shigella dysenteriae Sd197 3797272 YP_405622.1 CDS SDY_4229 NC_007606.1 3962369 3962734 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(3962369..3962734) Shigella dysenteriae Sd197 3797273 YP_405623.1 CDS fumB NC_007606.1 3963868 3965514 R fumarate hydratase Class I; anaerobic isozyme; Code: C; COG: COG1951; fumarase B complement(3963868..3965514) Shigella dysenteriae Sd197 3795671 YP_405624.1 CDS dcuB NC_007606.1 3965592 3966779 R ''functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters''; anaerobic C4-dicarboxylate transporter complement(3965592..3966779) Shigella dysenteriae Sd197 3795672 YP_405625.1 CDS insB NC_007606.1 3966914 3967291 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(3966914..3967291) Shigella dysenteriae Sd197 3795673 YP_405626.1 CDS insA NC_007606.1 3967336 3967611 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(3967336..3967611) Shigella dysenteriae Sd197 3795674 YP_405627.1 CDS SDY_4235 NC_007606.1 3968233 3968628 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3968233..3968628) Shigella dysenteriae Sd197 3795675 YP_009000857.1 CDS SDY_4784 NC_007606.1 3968655 3968927 R insertion element iso-IS1N protein InsA complement(3968655..3968927) Shigella dysenteriae Sd197 18263171 YP_405629.1 CDS yjdG NC_007606.1 3969054 3969773 R response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR complement(3969054..3969773) Shigella dysenteriae Sd197 3795677 YP_405630.1 CDS yjdH NC_007606.1 3969770 3971401 R C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS complement(3969770..3971401) Shigella dysenteriae Sd197 3795678 YP_405631.1 CDS yjdI NC_007606.1 3971582 3971812 D Code: S; COG: COG3592; hypothetical protein 3971582..3971812 Shigella dysenteriae Sd197 3795679 YP_405632.1 CDS yjdJ NC_007606.1 3971824 3972096 D Code: R; COG: COG2388; hypothetical protein 3971824..3972096 Shigella dysenteriae Sd197 3795680 YP_405633.1 CDS SDY_4241 NC_007606.1 3972446 3972841 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3972446..3972841) Shigella dysenteriae Sd197 3795681 YP_009000858.1 CDS SDY_4785 NC_007606.1 3972868 3973140 R insertion element iso-IS1N protein InsA complement(3972868..3973140) Shigella dysenteriae Sd197 18263172 YP_405634.1 CDS insB NC_007606.1 3973786 3974163 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3973786..3974163 Shigella dysenteriae Sd197 3795682 YP_405635.1 CDS SDY_4243 NC_007606.1 3974316 3974711 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(3974316..3974711) Shigella dysenteriae Sd197 3795683 YP_009000859.1 CDS SDY_4786 NC_007606.1 3974738 3975010 R insertion element iso-IS1N protein InsA complement(3974738..3975010) Shigella dysenteriae Sd197 18263173 YP_405637.1 CDS insA NC_007606.1 3975164 3975439 D Code: L; COG: COG3677; insertion element IS1 protein InsA 3975164..3975439 Shigella dysenteriae Sd197 3795685 YP_405638.1 CDS insB NC_007606.1 3975484 3975861 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3975484..3975861 Shigella dysenteriae Sd197 3795686 YP_405639.1 CDS ytfR NC_007606.1 3976254 3977756 D Code: G; COG: COG1129; ATPase 3976254..3977756 Shigella dysenteriae Sd197 3795687 YP_405640.1 CDS ytfT NC_007606.1 3977767 3978696 D Code: G; COG: COG1172; transport system permease 3977767..3978696 Shigella dysenteriae Sd197 3795688 YP_405641.1 CDS yjfF NC_007606.1 3978803 3979774 D membrane component of a sugar ABC transporter system; ABC transporter permease 3978803..3979774 Shigella dysenteriae Sd197 3795689 YP_405642.1 CDS fbp NC_007606.1 3979807 3980805 R ''catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate''; fructose-1,6-bisphosphatase complement(3979807..3980805) Shigella dysenteriae Sd197 3795690 YP_405643.1 CDS yjfG NC_007606.1 3980981 3982354 D Code: M; COG: COG0773; ligase 3980981..3982354 Shigella dysenteriae Sd197 3799112 YP_405644.1 CDS yjgA NC_007606.1 3982437 3982982 R Code: S; COG: COG3028; hypothetical protein complement(3982437..3982982) Shigella dysenteriae Sd197 3799113 YP_405645.1 CDS pmbA NC_007606.1 3983076 3984428 D maturation of antibiotic MccB17, see tld genes; protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 3983076..3984428 Shigella dysenteriae Sd197 3799114 YP_009000860.1 CDS SDY_4255a NC_007606.1 3984612 3984998 D cytochrome b562 3984612..3984998 Shigella dysenteriae Sd197 18263174 YP_405647.1 CDS relB NC_007606.1 3985189 3985428 D Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor; bifunctional antitoxin/transcriptional repressor RelB 3985189..3985428 Shigella dysenteriae Sd197 3799116 YP_405648.1 CDS nrdG NC_007606.1 3985429 3985893 R activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein complement(3985429..3985893) Shigella dysenteriae Sd197 3799117 YP_405649.1 CDS nrdD NC_007606.1 3986083 3988221 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(3986083..3988221) Shigella dysenteriae Sd197 3799118 YP_405650.1 CDS treC NC_007606.1 3988615 3990270 R Code: G; COG: COG0366; trehalose-6-phosphate hydrolase complement(3988615..3990270) Shigella dysenteriae Sd197 3799119 YP_405651.1 CDS treB NC_007606.1 3990320 3991741 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunit IIBC complement(3990320..3991741) Shigella dysenteriae Sd197 3799120 YP_405652.1 CDS treR NC_007606.1 3991860 3992807 R regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor complement(3991860..3992807) Shigella dysenteriae Sd197 3799121 YP_405653.1 CDS mgtA NC_007606.1 3993186 3995882 D P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 3993186..3995882 Shigella dysenteriae Sd197 3799122 YP_405654.1 CDS yjgF NC_007606.1 3996088 3996513 R Code: J; COG: COG0251; hypothetical protein complement(3996088..3996513) Shigella dysenteriae Sd197 3799123 YP_405655.1 CDS pyrI NC_007606.1 3996547 3997008 R involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase complement(3996547..3997008) Shigella dysenteriae Sd197 3799124 YP_405656.1 CDS pyrB NC_007606.1 3997021 3997956 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase complement(3997021..3997956) Shigella dysenteriae Sd197 3799125 YP_405657.1 CDS pyrL NC_007606.1 3997960 3998094 R pyrBI operon leader peptide complement(3997960..3998094) Shigella dysenteriae Sd197 3799126 YP_405658.1 CDS yjgH NC_007606.1 3998374 3998769 R Code: J; COG: COG0251; hypothetical protein complement(3998374..3998769) Shigella dysenteriae Sd197 3799127 YP_405659.1 CDS yjgI NC_007606.1 3998900 3999613 R Code: IQR; COG: COG1028; oxidoreductase complement(3998900..3999613) Shigella dysenteriae Sd197 3799128 YP_405661.2 CDS yjgJ NC_007606.1 3999684 4000277 D hypothetical protein 3999684..4000277 Shigella dysenteriae Sd197 3799130 YP_405660.1 CDS SDY_4268 NC_007606.1 3999787 3999951 D hypothetical protein 3999787..3999951 Shigella dysenteriae Sd197 3799129 YP_405662.1 CDS yjgK NC_007606.1 4000413 4000874 D Code: G; COG: COG2731; hypothetical protein 4000413..4000874 Shigella dysenteriae Sd197 3796938 YP_009000861.1 CDS SDY_4787 NC_007606.1 4001036 4001308 D insertion element iso-IS1N protein InsA 4001036..4001308 Shigella dysenteriae Sd197 18263175 YP_405664.1 CDS insA NC_007606.1 4001938 4002213 D Code: L; COG: COG3677; insertion element IS1 protein InsA 4001938..4002213 Shigella dysenteriae Sd197 3796940 YP_405665.1 CDS insB NC_007606.1 4002258 4002635 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4002258..4002635 Shigella dysenteriae Sd197 3796941 YP_405666.1 CDS SDY_4274 NC_007606.1 4002735 4003100 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 4002735..4003100 Shigella dysenteriae Sd197 3796942 YP_405667.2 CDS SDY_4275 NC_007606.1 4003058 4003963 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4003058..4003963 Shigella dysenteriae Sd197 3796943 YP_405668.1 CDS argI NC_007606.1 4004057 4005061 R ''catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.''; ornithine carbamoyltransferase subunit I complement(4004057..4005061) Shigella dysenteriae Sd197 3796944 YP_405669.1 CDS yjgD NC_007606.1 4005223 4005639 D Code: S; COG: COG3076; hypothetical protein 4005223..4005639 Shigella dysenteriae Sd197 3796945 YP_405670.2 CDS SDY_4278 NC_007606.1 4005684 4006187 R Code: KR; COG: COG0454; hypothetical protein complement(4005684..4006187) Shigella dysenteriae Sd197 3796946 YP_405671.1 CDS SDY_4279 NC_007606.1 4006225 4006620 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4006225..4006620) Shigella dysenteriae Sd197 3796947 YP_009000862.1 CDS SDY_4788 NC_007606.1 4006647 4006919 R insertion element iso-IS1N protein InsA complement(4006647..4006919) Shigella dysenteriae Sd197 18263176 YP_009000863.1 CDS SDY_4789 NC_007606.1 4007792 4008064 D insertion element iso-IS1N protein InsA 4007792..4008064 Shigella dysenteriae Sd197 18263177 YP_405672.1 CDS SDY_4281 NC_007606.1 4008091 4008486 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4008091..4008486 Shigella dysenteriae Sd197 3796949 YP_405673.1 CDS valS NC_007606.1 4009180 4012035 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(4009180..4012035) Shigella dysenteriae Sd197 3796950 YP_405674.1 CDS holC NC_007606.1 4012035 4012478 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(4012035..4012478) Shigella dysenteriae Sd197 3796951 YP_405675.1 CDS pepA NC_007606.1 4012736 4014247 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(4012736..4014247) Shigella dysenteriae Sd197 3796952 YP_405676.1 CDS yjgP NC_007606.1 4014514 4015614 D Code: R; COG: COG0795; hypothetical protein 4014514..4015614 Shigella dysenteriae Sd197 3796953 YP_405677.1 CDS yjgQ NC_007606.1 4015611 4016696 D Code: R; COG: COG0795; hypothetical protein 4015611..4016696 Shigella dysenteriae Sd197 3796954 YP_405678.1 CDS yjgR NC_007606.1 4016857 4018359 R Code: R; COG: COG0433; hypothetical protein complement(4016857..4018359) Shigella dysenteriae Sd197 3796955 YP_405679.1 CDS yjgB NC_007606.1 4018489 4019550 R Code: R; COG: COG1064; oxidoreductase complement(4018489..4019550) Shigella dysenteriae Sd197 3796956 YP_405681.1 CDS SDY_4292 NC_007606.1 4021038 4021340 R Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN complement(4021038..4021340) Shigella dysenteriae Sd197 3799249 YP_405682.1 CDS fecE NC_007606.1 4022300 4023067 R Part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate ABC transporter ATP-binding protein complement(4022300..4023067) Shigella dysenteriae Sd197 3799250 YP_405683.1 CDS fecD NC_007606.1 4023068 4024024 R ''Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter.''; iron-dicitrate transporter subunit FecD complement(4023068..4024024) Shigella dysenteriae Sd197 3799251 YP_405684.1 CDS fecC NC_007606.1 4024021 4025016 R part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate ABC transporter permease complement(4024021..4025016) Shigella dysenteriae Sd197 3799252 YP_405685.1 CDS fecA NC_007606.1 4025959 4028283 R Code: P; COG: COG4772; citrate-dependent iron transport, outer membrane receptor complement(4025959..4028283) Shigella dysenteriae Sd197 3799254 YP_405686.1 CDS fecI NC_007606.1 4029320 4029841 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport; RNA polymerase sigma factor FecI complement(4029320..4029841) Shigella dysenteriae Sd197 3799256 YP_009000864.1 CDS SDY_4790 NC_007606.1 4029995 4030267 D insertion element iso-IS1N protein InsA 4029995..4030267 Shigella dysenteriae Sd197 18263178 YP_405688.1 CDS SDY_4301 NC_007606.1 4030294 4030689 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4030294..4030689 Shigella dysenteriae Sd197 3799258 YP_405689.1 CDS insA NC_007606.1 4030907 4031182 D Code: L; COG: COG3677; insertion element IS1 7 protein InsA 4030907..4031182 Shigella dysenteriae Sd197 3799259 YP_405691.1 CDS SDY_4304 NC_007606.1 4033358 4034731 D hypothetical protein 4033358..4034731 Shigella dysenteriae Sd197 3799261 YP_405693.1 CDS SDY_4306 NC_007606.1 4036046 4036480 R hypothetical protein complement(4036046..4036480) Shigella dysenteriae Sd197 3799263 YP_405694.2 CDS SDY_4307 NC_007606.1 4036964 4037869 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(4036964..4037869) Shigella dysenteriae Sd197 3799264 YP_405695.1 CDS SDY_4308 NC_007606.1 4037827 4038192 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(4037827..4038192) Shigella dysenteriae Sd197 3796481 YP_405696.1 CDS yjbD NC_007606.1 4038476 4038748 D hypothetical protein 4038476..4038748 Shigella dysenteriae Sd197 3796482 YP_405697.1 CDS yjbC NC_007606.1 4038749 4039621 R catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F complement(4038749..4039621) Shigella dysenteriae Sd197 3796483 YP_405698.1 CDS SDY_4311 NC_007606.1 4039969 4040916 D Code: K; COG: COG2390; sorbose uptake and utilization genes transcriptional regulator 4039969..4040916 Shigella dysenteriae Sd197 3796484 YP_405701.1 CDS SDY_4315 NC_007606.1 4042122 4042919 D Code: G; COG: COG3715; PTS system sorbose transporter subunit IIC 4042122..4042919 Shigella dysenteriae Sd197 3796488 YP_405703.1 CDS SDY_4317 NC_007606.1 4043805 4045034 D Code: ER; COG: COG1063; L-sorbose 1-phosphate dehydrogenase 4043805..4045034 Shigella dysenteriae Sd197 3796490 YP_405704.1 CDS yjbB NC_007606.1 4046194 4047750 R Code: P; COG: COG1283; alpha helix protein complement(4046194..4047750) Shigella dysenteriae Sd197 3796492 YP_405705.1 CDS insB NC_007606.1 4048081 4048458 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(4048081..4048458) Shigella dysenteriae Sd197 3796493 YP_405706.1 CDS insA NC_007606.1 4048503 4048778 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(4048503..4048778) Shigella dysenteriae Sd197 3796494 YP_405707.1 CDS metH NC_007606.1 4048807 4052505 R repressor of metE and metF; one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase complement(4048807..4052505) Shigella dysenteriae Sd197 3796495 YP_405708.2 CDS iclR NC_007606.1 4052705 4053529 D ''regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase''; IclR family transcriptional regulator 4052705..4053529 Shigella dysenteriae Sd197 3796496 YP_405709.1 CDS SDY_4325 NC_007606.1 4055288 4055683 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4055288..4055683) Shigella dysenteriae Sd197 3796498 YP_009000865.1 CDS SDY_4791 NC_007606.1 4055710 4055982 R insertion element iso-IS1N protein InsA complement(4055710..4055982) Shigella dysenteriae Sd197 18263179 YP_405711.1 CDS aceK NC_007606.1 4056062 4057798 R catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase complement(4056062..4057798) Shigella dysenteriae Sd197 3796500 YP_405712.1 CDS aceA NC_007606.1 4057982 4059286 R Code: C; COG: COG2224; isocitrate lyase complement(4057982..4059286) Shigella dysenteriae Sd197 3797899 YP_405713.1 CDS metA NC_007606.1 4061145 4062074 R catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase complement(4061145..4062074) Shigella dysenteriae Sd197 3797901 YP_405714.1 CDS insB NC_007606.1 4062208 4062585 R Code: L; COG: COG1662; insertion sequence element IS1 transposase complement(4062208..4062585) Shigella dysenteriae Sd197 3797902 YP_405715.1 CDS insA NC_007606.1 4062630 4062905 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(4062630..4062905) Shigella dysenteriae Sd197 3797903 YP_405716.1 CDS yjaB NC_007606.1 4063007 4063450 D Code: KR; COG: COG0454; hypothetical protein 4063007..4063450 Shigella dysenteriae Sd197 3797904 YP_405717.1 CDS yjaA NC_007606.1 4063514 4063897 R hypothetical protein complement(4063514..4063897) Shigella dysenteriae Sd197 3797905 YP_405718.1 CDS SDY_4335 NC_007606.1 4064021 4065367 D Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG 4064021..4065367 Shigella dysenteriae Sd197 3797906 YP_009000866.1 CDS SDY_4792 NC_007606.1 4065894 4066166 D insertion element iso-IS1N protein InsA 4065894..4066166 Shigella dysenteriae Sd197 18263180 YP_405719.1 CDS SDY_4337 NC_007606.1 4066193 4066540 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4066193..4066540 Shigella dysenteriae Sd197 3797908 YP_405720.1 CDS insA NC_007606.1 4066574 4066849 D Code: L; COG: COG3677; insertion element IS1 protein InsA 4066574..4066849 Shigella dysenteriae Sd197 3797909 YP_405721.1 CDS insB NC_007606.1 4066894 4067271 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4066894..4067271 Shigella dysenteriae Sd197 3797910 YP_405722.1 CDS yiaH NC_007606.1 4067282 4068280 R Code: S; COG: COG3274; hypothetical protein complement(4067282..4068280) Shigella dysenteriae Sd197 3797911 YP_405723.1 CDS SDY_4341 NC_007606.1 4068418 4068720 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 4068418..4068720 Shigella dysenteriae Sd197 3797912 YP_405724.1 CDS SDY_4342 NC_007606.1 4068861 4069691 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 4068861..4069691 Shigella dysenteriae Sd197 3797913 YP_405725.1 CDS SDY_4343 NC_007606.1 4069724 4070023 D hypothetical protein 4069724..4070023 Shigella dysenteriae Sd197 3797914 YP_405726.1 CDS glyQ NC_007606.1 4070118 4071029 D glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 4070118..4071029 Shigella dysenteriae Sd197 3797915 YP_405727.1 CDS glyS NC_007606.1 4071039 4073108 D glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 4071039..4073108 Shigella dysenteriae Sd197 3797916 YP_405728.1 CDS yiaZ NC_007606.1 4073431 4073583 D small toxic polypeptide 4073431..4073583 Shigella dysenteriae Sd197 3797917 YP_405729.1 CDS cspA NC_007606.1 4073771 4073983 R transcriptional activator of hns; Code: K; COG: COG1278; cold-shock protein complement(4073771..4073983) Shigella dysenteriae Sd197 3798157 YP_405730.1 CDS yiaG NC_007606.1 4074264 4074554 R Code: K; COG: COG2944; transcriptional regulator complement(4074264..4074554) Shigella dysenteriae Sd197 3798158 YP_405731.1 CDS yiaF NC_007606.1 4074812 4075642 D hypothetical protein 4074812..4075642 Shigella dysenteriae Sd197 3798159 YP_405732.2 CDS yiaE NC_007606.1 4075692 4076666 R Code: CHR; COG: COG1052; dehydrogenase complement(4075692..4076666) Shigella dysenteriae Sd197 3798160 YP_405733.1 CDS bisC NC_007606.1 4077283 4079502 D Code: C; COG: COG0243; biotin sulfoxide reductase 4077283..4079502 Shigella dysenteriae Sd197 3798162 YP_405734.1 CDS tag NC_007606.1 4079908 4080471 R ''constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine''; 3-methyladenine DNA glycosylase complement(4079908..4080471) Shigella dysenteriae Sd197 3798163 YP_009000867.1 CDS SDY_4793 NC_007606.1 4082831 4083103 D insertion element iso-IS1N protein InsA 4082831..4083103 Shigella dysenteriae Sd197 18263181 YP_405736.1 CDS SDY_4356 NC_007606.1 4083130 4083525 D Code: L; COG: COG1662; insertion element IS1 protein InsB 4083130..4083525 Shigella dysenteriae Sd197 3798166 YP_405737.1 CDS yjfN NC_007606.1 4083607 4083909 R hypothetical protein complement(4083607..4083909) Shigella dysenteriae Sd197 3798167 YP_405738.2 CDS yjfO NC_007606.1 4084031 4084360 R hypothetical protein complement(4084031..4084360) Shigella dysenteriae Sd197 3798168 YP_405739.1 CDS yjfP NC_007606.1 4084542 4085291 D YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4084542..4085291 Shigella dysenteriae Sd197 3798169 YP_405740.1 CDS yjfQ NC_007606.1 4085288 4086043 R negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR complement(4085288..4086043) Shigella dysenteriae Sd197 3798170 YP_405742.2 CDS ulaA NC_007606.1 4087560 4088957 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4087560..4088957 Shigella dysenteriae Sd197 3798172 YP_405743.1 CDS sgaB NC_007606.1 4088973 4089278 D Code: G; COG: COG3414; PTS system L-ascorbate-specific transporter subunit IIB 4088973..4089278 Shigella dysenteriae Sd197 3798173 YP_405744.1 CDS ptxA NC_007606.1 4089288 4089752 D Code: GT; COG: COG1762; PTS system L-ascorbate-specific transporter subunit IIA 4089288..4089752 Shigella dysenteriae Sd197 3798174 YP_405745.1 CDS ulaD NC_007606.1 4089766 4090416 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4089766..4090416 Shigella dysenteriae Sd197 3798175 YP_405746.1 CDS sgaE NC_007606.1 4091280 4091966 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4091280..4091966 Shigella dysenteriae Sd197 3797690 YP_405747.1 CDS rpsF NC_007606.1 4092697 4093092 D ''binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21''; 30S ribosomal protein S6 4092697..4093092 Shigella dysenteriae Sd197 3797692 YP_405748.1 CDS priB NC_007606.1 4093099 4093413 D binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4093099..4093413 Shigella dysenteriae Sd197 3797693 YP_405749.1 CDS rpsR NC_007606.1 4093418 4093645 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4093418..4093645 Shigella dysenteriae Sd197 3797694 YP_405750.1 CDS rplI NC_007606.1 4093687 4094136 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4093687..4094136 Shigella dysenteriae Sd197 3797695 YP_405751.1 CDS SDY_4373 NC_007606.1 4095003 4095398 R Code: L; COG: COG1662; insertion element IS1 protein InsB complement(4095003..4095398) Shigella dysenteriae Sd197 3797696 YP_009000868.1 CDS SDY_4794 NC_007606.1 4095425 4095697 R insertion element iso-IS1N protein InsA complement(4095425..4095697) Shigella dysenteriae Sd197 18263182 YP_405752.1 CDS insA NC_007606.1 4095834 4096109 D Code: L; COG: COG3677; insertion element IS1 protein InsA 4095834..4096109 Shigella dysenteriae Sd197 3797697 YP_405753.1 CDS insB NC_007606.1 4096154 4096531 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4096154..4096531 Shigella dysenteriae Sd197 3797698 YP_405754.1 CDS ytfB NC_007606.1 4096641 4097315 R Code: M; COG: COG3061; hypothetical protein complement(4096641..4097315) Shigella dysenteriae Sd197 3797699 YP_405755.2 CDS fklB NC_007606.1 4097497 4098117 D rotamase; FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4097497..4098117 Shigella dysenteriae Sd197 3797700 YP_405756.1 CDS cycA NC_007606.1 4098426 4099838 D ''involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine''; D-alanine/D-serine/glycine permease 4098426..4099838 Shigella dysenteriae Sd197 3797701 YP_405757.1 CDS ytfE NC_007606.1 4099883 4100545 R Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein complement(4099883..4100545) Shigella dysenteriae Sd197 3797702 YP_405758.1 CDS ytfF NC_007606.1 4100648 4101622 R Code: GER; COG: COG0697; transmembrane subunit complement(4100648..4101622) Shigella dysenteriae Sd197 3797703 YP_405759.1 CDS ytfG NC_007606.1 4101721 4102581 R Code: MG; COG: COG0702; oxidoreductase complement(4101721..4102581) Shigella dysenteriae Sd197 3797705 YP_405760.1 CDS ytfH NC_007606.1 4102580 4103050 D Code: K; COG: COG1733; hypothetical protein 4102580..4103050 Shigella dysenteriae Sd197 3797704 YP_405761.1 CDS cpdB NC_007606.1 4103167 4105116 R ''periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate''; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein complement(4103167..4105116) Shigella dysenteriae Sd197 3797706 YP_405762.1 CDS SDY_4384 NC_007606.1 4105117 4105512 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4105117..4105512) Shigella dysenteriae Sd197 3797707 YP_009000869.1 CDS SDY_4795 NC_007606.1 4105539 4105811 R insertion element iso-IS1N protein InsA complement(4105539..4105811) Shigella dysenteriae Sd197 18263183 YP_405763.1 CDS cysQ NC_007606.1 4106074 4106814 D affects pool of 3'-phosphoadenosine-5'-phosphosulfate in pathway of sulfite synthesis; ''catalyzes the formation of AMP from adenosine-3',5'-bisphosphate''; adenosine-3'(2'),5'-bisphosphate nucleotidase 4106074..4106814 Shigella dysenteriae Sd197 3797708 YP_405764.1 CDS insB NC_007606.1 4107001 4107378 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(4107001..4107378) Shigella dysenteriae Sd197 3798197 YP_405765.1 CDS insA NC_007606.1 4107423 4107698 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(4107423..4107698) Shigella dysenteriae Sd197 3798198 YP_405766.1 CDS SDY_4388 NC_007606.1 4107769 4108164 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4107769..4108164) Shigella dysenteriae Sd197 3798199 YP_009000870.1 CDS SDY_4796 NC_007606.1 4108191 4108463 R insertion element iso-IS1N protein InsA complement(4108191..4108463) Shigella dysenteriae Sd197 18263184 YP_405767.1 CDS yjeK NC_007606.1 4108569 4109597 R Code: E; COG: COG1509; hypothetical protein complement(4108569..4109597) Shigella dysenteriae Sd197 3798200 YP_405768.1 CDS efp NC_007606.1 4109639 4110205 D EF-P; Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4109639..4110205 Shigella dysenteriae Sd197 3798201 YP_405769.1 CDS SDY_4391 NC_007606.1 4110257 4110382 D acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 4110257..4110382 Shigella dysenteriae Sd197 3798202 YP_405770.2 CDS sugE NC_007606.1 4110815 4111132 D suppresses groEL, may be chaperone; Code: P; COG: COG2076; SugE protein 4110815..4111132 Shigella dysenteriae Sd197 3798203 YP_405771.1 CDS blc NC_007606.1 4111129 4111662 R lipocalin; lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc complement(4111129..4111662) Shigella dysenteriae Sd197 3798204 YP_405772.1 CDS ampC NC_007606.1 4111751 4112884 R penicillin resistance; Code: V; COG: COG1680; beta-lactamase complement(4111751..4112884) Shigella dysenteriae Sd197 3798205 YP_405773.1 CDS frdD NC_007606.1 4112947 4113306 R membrane anchor polypeptide; in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D complement(4112947..4113306) Shigella dysenteriae Sd197 3798206 YP_405774.1 CDS frdC NC_007606.1 4113317 4113712 R membrane anchor polypeptide; ''part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB''; fumarate reductase subunit C complement(4113317..4113712) Shigella dysenteriae Sd197 3798207 YP_405775.1 CDS frdB NC_007606.1 4113723 4114457 R ''part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB''; fumarate reductase iron-sulfur subunit complement(4113723..4114457) Shigella dysenteriae Sd197 3798208 YP_405776.1 CDS frdA NC_007606.1 4114450 4116258 R ''part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB''; fumarate reductase flavoprotein subunit complement(4114450..4116258) Shigella dysenteriae Sd197 3798209 YP_405777.2 CDS yjeA NC_007606.1 4116583 4117560 D lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4116583..4117560 Shigella dysenteriae Sd197 3798210 YP_009000871.1 CDS SDY_4797 NC_007606.1 4118239 4118511 R insertion element iso-IS1N protein InsA complement(4118239..4118511) Shigella dysenteriae Sd197 18263185 YP_405780.1 CDS yjfM NC_007606.1 4118639 4119277 D Code: S; COG: COG5463; hypothetical protein 4118639..4119277 Shigella dysenteriae Sd197 3798213 YP_405781.1 CDS yjfC NC_007606.1 4119280 4120443 D Code: E; COG: COG0754; synthetase/amidase 4119280..4120443 Shigella dysenteriae Sd197 3798214 YP_405782.1 CDS aidB NC_007606.1 4120512 4122140 D catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4120512..4122140 Shigella dysenteriae Sd197 3798215 YP_009000872.1 CDS SDY_4798 NC_007606.1 4122255 4122527 D insertion element iso-IS1N protein InsA 4122255..4122527 Shigella dysenteriae Sd197 18263186 YP_405784.1 CDS SDY_4406 NC_007606.1 4122554 4122949 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4122554..4122949 Shigella dysenteriae Sd197 3797368 YP_405785.1 CDS insA NC_007606.1 4123058 4123333 D Code: L; COG: COG3677; insertion element IS1 protein InsA 4123058..4123333 Shigella dysenteriae Sd197 3797369 YP_405786.1 CDS insB NC_007606.1 4123378 4123755 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4123378..4123755 Shigella dysenteriae Sd197 3797370 YP_405787.1 CDS yjfH NC_007606.1 4123832 4124563 R Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase complement(4123832..4124563) Shigella dysenteriae Sd197 3797371 YP_405788.2 CDS vacB NC_007606.1 4124744 4127173 R ''3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs''; exoribonuclease R complement(4124744..4127173) Shigella dysenteriae Sd197 3797372 YP_405789.1 CDS yjeB NC_007606.1 4127212 4127637 R negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR complement(4127212..4127637) Shigella dysenteriae Sd197 3797373 YP_405790.1 CDS purA NC_007606.1 4127842 4129140 R ''catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis''; adenylosuccinate synthetase complement(4127842..4129140) Shigella dysenteriae Sd197 3797374 YP_405791.1 CDS yjeT NC_007606.1 4129244 4129441 R Code: S; COG: COG3242; hypothetical protein complement(4129244..4129441) Shigella dysenteriae Sd197 3797375 YP_405792.1 CDS hflC NC_007606.1 4129523 4130527 R with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC complement(4129523..4130527) Shigella dysenteriae Sd197 3797376 YP_405793.1 CDS hflK NC_007606.1 4130530 4131789 R with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK complement(4130530..4131789) Shigella dysenteriae Sd197 3797377 YP_405794.1 CDS hflX NC_007606.1 4131875 4133155 R involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX complement(4131875..4133155) Shigella dysenteriae Sd197 3797378 YP_405795.1 CDS hfq NC_007606.1 4133231 4133539 R a growth-related protein; Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq complement(4133231..4133539) Shigella dysenteriae Sd197 3797379 YP_405796.1 CDS miaA NC_007606.1 4133625 4134575 R IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase complement(4133625..4134575) Shigella dysenteriae Sd197 3797380 YP_405797.1 CDS mutL NC_007606.1 4134568 4136415 R enzyme in methyl-directed mismatch repair; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein complement(4134568..4136415) Shigella dysenteriae Sd197 3797381 YP_405798.1 CDS amiB NC_007606.1 4136425 4137762 R a murein hydrolase; Code: M; COG: COG0860; N-acetylmuramoyl-L-alanine amidase complement(4136425..4137762) Shigella dysenteriae Sd197 3797382 YP_405799.1 CDS yjeE NC_007606.1 4137781 4138242 R possibly involved in cell wall synthesis; ATPase complement(4137781..4138242) Shigella dysenteriae Sd197 3797383 YP_405800.1 CDS SDY_4422 NC_007606.1 4139419 4139814 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4139419..4139814) Shigella dysenteriae Sd197 3797384 YP_009000873.1 CDS SDY_4799 NC_007606.1 4139841 4140113 R insertion element iso-IS1N protein InsA complement(4139841..4140113) Shigella dysenteriae Sd197 18263187 YP_405802.1 CDS SDY_4424 NC_007606.1 4140193 4140588 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4140193..4140588) Shigella dysenteriae Sd197 3797386 YP_009000874.1 CDS SDY_4800 NC_007606.1 4140615 4140887 R insertion element iso-IS1N protein InsA complement(4140615..4140887) Shigella dysenteriae Sd197 18263188 YP_405803.1 CDS yjeS NC_007606.1 4141308 4142447 D Code: C; COG: COG1600; hypothetical protein 4141308..4142447 Shigella dysenteriae Sd197 3797353 YP_405804.2 CDS yjeR NC_007606.1 4143225 4143770 R 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease complement(4143225..4143770) Shigella dysenteriae Sd197 3797358 YP_405805.2 CDS yjeQ NC_007606.1 4143865 4144917 D EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 4143865..4144917 Shigella dysenteriae Sd197 3797359 YP_405806.1 CDS psd NC_007606.1 4145014 4145982 D phospholipid synthesis; catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 4145014..4145982 Shigella dysenteriae Sd197 3797360 YP_405807.1 CDS yjeP NC_007606.1 4146004 4149327 D Code: M; COG: COG3264; hypothetical protein 4146004..4149327 Shigella dysenteriae Sd197 3797361 YP_405808.1 CDS yjeM NC_007606.1 4149478 4150959 R Code: E; COG: COG0531; transporter complement(4149478..4150959) Shigella dysenteriae Sd197 3797362 YP_405809.1 CDS SDY_4435 NC_007606.1 4150980 4151375 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4150980..4151375) Shigella dysenteriae Sd197 3797363 YP_009000875.1 CDS SDY_4801 NC_007606.1 4151402 4151674 R insertion element iso-IS1N protein InsA complement(4151402..4151674) Shigella dysenteriae Sd197 18263189 YP_405811.1 CDS insB NC_007606.1 4151918 4152295 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(4151918..4152295) Shigella dysenteriae Sd197 3797365 YP_405812.1 CDS insA NC_007606.1 4152340 4152615 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(4152340..4152615) Shigella dysenteriae Sd197 3797366 YP_405814.1 CDS dipZ NC_007606.1 4154160 4155857 R copper tolerance; two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein complement(4154160..4155857) Shigella dysenteriae Sd197 3798332 YP_405815.1 CDS cutA NC_007606.1 4155833 4156171 R cytochrome c biogenesis; copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA complement(4155833..4156171) Shigella dysenteriae Sd197 3798333 YP_405816.1 CDS dcuA NC_007606.1 4156287 4157588 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(4156287..4157588) Shigella dysenteriae Sd197 3798334 YP_405817.1 CDS aspA NC_007606.1 4157706 4159187 R aspartase; catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(4157706..4159187) Shigella dysenteriae Sd197 3798335 YP_405818.1 CDS fxsA NC_007606.1 4159478 4159954 D Protein affecting phage T7 exclusion by the F plasmid; F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 4159478..4159954 Shigella dysenteriae Sd197 3798336 YP_405819.1 CDS SDY_4446 NC_007606.1 4160023 4160418 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4160023..4160418) Shigella dysenteriae Sd197 3798337 YP_009000876.1 CDS SDY_4802 NC_007606.1 4160445 4160717 R insertion element iso-IS1N protein InsA complement(4160445..4160717) Shigella dysenteriae Sd197 18263190 YP_405820.1 CDS yjeH NC_007606.1 4160753 4162000 R uncharacterized member of the APC superfamily of amino acid transporters; unknown function; hypothetical protein complement(4160753..4162000) Shigella dysenteriae Sd197 3798338 YP_405821.1 CDS groES NC_007606.1 4162276 4162569 D 10 kDa chaperone binds to Hsp60 in pres. Mg-ATP, suppressing its ATPase activity; 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4162276..4162569 Shigella dysenteriae Sd197 3798339 YP_405822.1 CDS groEL NC_007606.1 4162613 4164259 D chaperone Hsp60, peptide-dependent ATPase, heat shock protein; ''60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth''; molecular chaperone GroEL 4162613..4164259 Shigella dysenteriae Sd197 3798340 YP_405823.1 CDS yjeI NC_007606.1 4164364 4164750 D hypothetical protein 4164364..4164750 Shigella dysenteriae Sd197 3798341 YP_009000877.1 CDS SDY_4803 NC_007606.1 4165174 4165446 D insertion element iso-IS1N protein InsA 4165174..4165446 Shigella dysenteriae Sd197 18263191 YP_405824.1 CDS SDY_4452 NC_007606.1 4165473 4165868 D Code: L; COG: COG1662; insertion element IS1 protein InsB 4165473..4165868 Shigella dysenteriae Sd197 3798343 YP_405825.1 CDS ytfJ NC_007606.1 4166304 4166858 R Code: R; COG: COG3054; hypothetical protein complement(4166304..4166858) Shigella dysenteriae Sd197 3798344 YP_405826.1 CDS ytfK NC_007606.1 4167144 4167389 D hypothetical protein 4167144..4167389 Shigella dysenteriae Sd197 3798345 YP_405827.1 CDS ytfL NC_007606.1 4167468 4168811 R Code: R; COG: COG1253; transport protein complement(4167468..4168811) Shigella dysenteriae Sd197 3798346 YP_405828.1 CDS msrA NC_007606.1 4169134 4169772 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(4169134..4169772) Shigella dysenteriae Sd197 3798347 YP_405829.1 CDS ytfM NC_007606.1 4169978 4171711 D Code: M; COG: COG0729; hypothetical protein 4169978..4171711 Shigella dysenteriae Sd197 3798348 YP_405830.1 CDS ytfN NC_007606.1 4171708 4175487 D Code: S; COG: COG2911; hypothetical protein 4171708..4175487 Shigella dysenteriae Sd197 3797519 YP_405831.1 CDS ytfP NC_007606.1 4175490 4175831 D Code: S; COG: COG2105; hypothetical protein 4175490..4175831 Shigella dysenteriae Sd197 3797520 YP_405832.1 CDS chpS NC_007606.1 4176037 4176294 D part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 4176037..4176294 Shigella dysenteriae Sd197 3797521 YP_405833.1 CDS chpB NC_007606.1 4176288 4176638 D toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 4176288..4176638 Shigella dysenteriae Sd197 3797522 YP_405834.1 CDS ppa NC_007606.1 4176715 4177245 R catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase complement(4176715..4177245) Shigella dysenteriae Sd197 3797523 YP_405835.1 CDS SDY_4464 NC_007606.1 4178069 4178464 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4178069..4178464) Shigella dysenteriae Sd197 3797525 YP_009000878.1 CDS SDY_4804 NC_007606.1 4178491 4178763 R insertion element iso-IS1N protein InsA complement(4178491..4178763) Shigella dysenteriae Sd197 18263192 YP_405836.1 CDS yjdL NC_007606.1 4182188 4183645 D Code: E; COG: COG3104; peptide transporter 4182188..4183645 Shigella dysenteriae Sd197 3797528 YP_405837.1 CDS SDY_4469 NC_007606.1 4184098 4184811 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(4184098..4184811) Shigella dysenteriae Sd197 3797530 YP_405838.1 CDS SDY_4470 NC_007606.1 4185270 4186106 D Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein 4185270..4186106 Shigella dysenteriae Sd197 3797531 YP_009000879.1 CDS SDY_4805 NC_007606.1 4188024 4188296 D insertion element iso-IS1N protein InsA 4188024..4188296 Shigella dysenteriae Sd197 18263193 YP_405840.1 CDS SDY_4473 NC_007606.1 4188323 4188718 D Code: L; COG: COG1662; insertion element IS1 protein InsB 4188323..4188718 Shigella dysenteriae Sd197 3797534 YP_405841.1 CDS SDY_4474 NC_007606.1 4188742 4189452 D Code: L; COG: COG3328; transposase 4188742..4189452 Shigella dysenteriae Sd197 3797535 YP_009000880.1 CDS SDY_4806 NC_007606.1 4190220 4190492 D insertion element iso-IS1N protein InsA 4190220..4190492 Shigella dysenteriae Sd197 18263194 YP_405843.1 CDS SDY_4476 NC_007606.1 4190519 4190914 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4190519..4190914 Shigella dysenteriae Sd197 3797537 YP_405844.1 CDS evgA NC_007606.1 4191566 4192180 D sensor EvgS; ''response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance''; DNA-binding transcriptional activator EvgA 4191566..4192180 Shigella dysenteriae Sd197 3798599 YP_405845.1 CDS evgS NC_007606.1 4192185 4195778 D Code: ET; COG: COG0834; hybrid sensory histidine kinase in two-component regulatory system with EvgA 4192185..4195778 Shigella dysenteriae Sd197 3798600 YP_405846.1 CDS SDY_4479 NC_007606.1 4195938 4197476 R Code: L; COG: COG3436; insertion sequence element ISSfl4 transposase complement(4195938..4197476) Shigella dysenteriae Sd197 3798601 YP_405847.1 CDS SDY_4480 NC_007606.1 4197526 4197873 R Code: L; COG: COG3436; insertion sequence element ISSfl4 ORF2 complement(4197526..4197873) Shigella dysenteriae Sd197 3798602 YP_405848.1 CDS SDY_4481 NC_007606.1 4198920 4199255 D Code: L; COG: COG3436; insertion sequence element ISSfl4 ORF2 4198920..4199255 Shigella dysenteriae Sd197 3798603 YP_405849.1 CDS SDY_4482 NC_007606.1 4199275 4199685 D hypothetical protein 4199275..4199685 Shigella dysenteriae Sd197 3798604 YP_405850.1 CDS insA NC_007606.1 4199817 4200092 D Code: L; COG: COG3677; insertion element IS1 protein InsA 4199817..4200092 Shigella dysenteriae Sd197 3798605 YP_405851.1 CDS insB NC_007606.1 4200137 4200514 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4200137..4200514 Shigella dysenteriae Sd197 3798606 YP_405852.1 CDS SDY_4485 NC_007606.1 4200709 4201422 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 4200709..4201422 Shigella dysenteriae Sd197 3798607 YP_405853.1 CDS SDY_4486 NC_007606.1 4201419 4201622 R hypothetical protein complement(4201419..4201622) Shigella dysenteriae Sd197 3798608 YP_009000881.1 CDS SDY_4807 NC_007606.1 4202174 4202446 D insertion element iso-IS1N protein InsA 4202174..4202446 Shigella dysenteriae Sd197 18263195 YP_405854.1 CDS SDY_4487 NC_007606.1 4202473 4202868 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4202473..4202868 Shigella dysenteriae Sd197 3798609 YP_405855.1 CDS SDY_4488 NC_007606.1 4202980 4203927 R hypothetical protein complement(4202980..4203927) Shigella dysenteriae Sd197 3798610 YP_405856.1 CDS SDY_4489 NC_007606.1 4204174 4204569 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4204174..4204569) Shigella dysenteriae Sd197 3798611 YP_009000882.1 CDS SDY_4808 NC_007606.1 4204596 4204868 R insertion element iso-IS1N protein InsA complement(4204596..4204868) Shigella dysenteriae Sd197 18263196 YP_405857.1 CDS SDY_4490 NC_007606.1 4205317 4206093 R Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein complement(4205317..4206093) Shigella dysenteriae Sd197 3798612 YP_405858.1 CDS SDY_4491 NC_007606.1 4206234 4206536 R Code: L; COG: COG2963; insertion sequence element IS600 transposase complement(4206234..4206536) Shigella dysenteriae Sd197 3798613 YP_405859.1 CDS SDY_4492 NC_007606.1 4206637 4206981 D hypothetical protein 4206637..4206981 Shigella dysenteriae Sd197 3798614 YP_405862.1 CDS SDY_4495 NC_007606.1 4207854 4208156 R Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN complement(4207854..4208156) Shigella dysenteriae Sd197 3798617 YP_009000883.1 CDS SDY_4809 NC_007606.1 4208255 4208527 D insertion element iso-IS1N protein InsA 4208255..4208527 Shigella dysenteriae Sd197 18263197 YP_405863.1 CDS SDY_4496 NC_007606.1 4208554 4208949 D Code: L; COG: COG1662; insertion element IS1 protein InsB 4208554..4208949 Shigella dysenteriae Sd197 3798637 YP_405864.1 CDS yicL NC_007606.1 4210361 4211284 D Code: GER; COG: COG0697; permease 4210361..4211284 Shigella dysenteriae Sd197 3798639 YP_405865.1 CDS nlpA NC_007606.1 4211288 4212106 R Code: P; COG: COG1464; hypothetical protein complement(4211288..4212106) Shigella dysenteriae Sd197 3798640 YP_405866.1 CDS insB NC_007606.1 4212189 4212566 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(4212189..4212566) Shigella dysenteriae Sd197 3798641 YP_405867.1 CDS insA NC_007606.1 4212611 4212886 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(4212611..4212886) Shigella dysenteriae Sd197 3798642 YP_405868.1 CDS yjcE NC_007606.1 4213119 4214768 R Code: P; COG: COG0025; hypothetical protein complement(4213119..4214768) Shigella dysenteriae Sd197 3798643 YP_405869.1 CDS yjcD NC_007606.1 4214919 4216268 R Code: R; COG: COG2252; hypothetical protein complement(4214919..4216268) Shigella dysenteriae Sd197 3798644 YP_405870.1 CDS soxR NC_007606.1 4216815 4217279 R Code: K; COG: COG0789; redox-sensing activator of soxS complement(4216815..4217279) Shigella dysenteriae Sd197 3798645 YP_405871.1 CDS soxS NC_007606.1 4217365 4217688 D regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 4217365..4217688 Shigella dysenteriae Sd197 3798646 YP_009000884.1 CDS SDY_4810 NC_007606.1 4217957 4218229 D insertion element iso-IS1N protein InsA 4217957..4218229 Shigella dysenteriae Sd197 18263198 YP_405872.1 CDS SDY_4506 NC_007606.1 4218256 4218651 D Code: L; COG: COG1662; insertion element IS1 protein InsB 4218256..4218651 Shigella dysenteriae Sd197 3798647 YP_405873.2 CDS yjcB NC_007606.1 4219013 4219294 D hypothetical protein 4219013..4219294 Shigella dysenteriae Sd197 3798648 YP_405874.1 CDS ssb NC_007606.1 4219393 4219929 R binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein complement(4219393..4219929) Shigella dysenteriae Sd197 3798649 YP_405875.1 CDS uvrA NC_007606.1 4220183 4223005 D ''The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate''; excinuclease ABC subunit A 4220183..4223005 Shigella dysenteriae Sd197 3798650 YP_405876.1 CDS yjbR NC_007606.1 4223040 4223396 R Code: S; COG: COG2315; hypothetical protein complement(4223040..4223396) Shigella dysenteriae Sd197 3798651 YP_405877.1 CDS yjbQ NC_007606.1 4223400 4223816 R Code: S; COG: COG0432; hypothetical protein complement(4223400..4223816) Shigella dysenteriae Sd197 3798652 YP_405878.1 CDS insB NC_007606.1 4224140 4224517 R Code: L; COG: COG1662; insertion element iso-IS1d protein InsB complement(4224140..4224517) Shigella dysenteriae Sd197 3798653 YP_405879.1 CDS insA NC_007606.1 4224562 4224837 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(4224562..4224837) Shigella dysenteriae Sd197 3798654 YP_009000885.1 CDS SDY_4811 NC_007606.1 4225640 4225912 D insertion element iso-IS1N protein InsA 4225640..4225912 Shigella dysenteriae Sd197 18263199 YP_405882.1 CDS SDY_4517 NC_007606.1 4226602 4227087 D hypothetical protein 4226602..4227087 Shigella dysenteriae Sd197 3795712 YP_405885.1 CDS tyrB NC_007606.1 4228095 4229288 R tyrosine repressible; catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase complement(4228095..4229288) Shigella dysenteriae Sd197 3795715 YP_405886.1 CDS alr NC_007606.1 4229531 4230610 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(4229531..4230610) Shigella dysenteriae Sd197 3795716 YP_405887.1 CDS dnaB NC_007606.1 4230663 4232078 R part of primosome; unwinds double stranded DNA; replicative DNA helicase complement(4230663..4232078) Shigella dysenteriae Sd197 3795717 YP_405888.1 CDS qor NC_007606.1 4232161 4233144 D Code: CR; COG: COG0604; quinone oxidoreductase 4232161..4233144 Shigella dysenteriae Sd197 3795718 YP_405889.2 CDS pspG NC_007606.1 4233310 4233552 R coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G complement(4233310..4233552) Shigella dysenteriae Sd197 3795719 YP_405890.1 CDS yjbN NC_007606.1 4233686 4234723 R Code: J; COG: COG0042; tRNA-dihydrouridine synthase A complement(4233686..4234723) Shigella dysenteriae Sd197 3795720 YP_405892.1 CDS SDY_4527 NC_007606.1 4235281 4235607 D hypothetical protein 4235281..4235607 Shigella dysenteriae Sd197 3795722 YP_009000886.1 CDS SDY_4527a NC_007606.1 4235569 4235859 R hypothetical protein complement(4235569..4235859) Shigella dysenteriae Sd197 18263200 YP_405893.2 CDS yjbK NC_007606.1 4236178 4236693 D ''Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB''; zinc uptake transcriptional repressor 4236178..4236693 Shigella dysenteriae Sd197 3795723 YP_405894.1 CDS yjbJ NC_007606.1 4236735 4236944 R unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein complement(4236735..4236944) Shigella dysenteriae Sd197 3795724 YP_405895.2 CDS dinF NC_007606.1 4237060 4238385 R Code: V; COG: COG0534; DNA-damage-inducible SOS response protein complement(4237060..4238385) Shigella dysenteriae Sd197 3795725 YP_405896.1 CDS lexA NC_007606.1 4238458 4239066 R regulator for lexA regulon; Represses a number of genes involved in the response to DNA damage; LexA repressor complement(4238458..4239066) Shigella dysenteriae Sd197 3795726 YP_405897.1 CDS dgkA NC_007606.1 4239176 4239544 R Code: M; COG: COG0818; diacylglycerol kinase complement(4239176..4239544) Shigella dysenteriae Sd197 3795727 YP_405898.2 CDS plsB NC_007606.1 4239715 4242138 D PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 4239715..4242138 Shigella dysenteriae Sd197 3795728 YP_405899.1 CDS ubiA NC_007606.1 4242293 4243165 R ''catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway''; 4-hydroxybenzoate octaprenyltransferase complement(4242293..4243165) Shigella dysenteriae Sd197 3795729 YP_405900.2 CDS ubiC NC_007606.1 4243178 4243675 R catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase complement(4243178..4243675) Shigella dysenteriae Sd197 3795538 YP_405901.1 CDS insA NC_007606.1 4244222 4244497 D Code: L; COG: COG3677; insertion element IS1 protein InsA 4244222..4244497 Shigella dysenteriae Sd197 3795539 YP_405902.1 CDS insB NC_007606.1 4244542 4244919 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4244542..4244919 Shigella dysenteriae Sd197 3795540 YP_009000887.1 CDS SDY_4812 NC_007606.1 4246204 4246476 D insertion element iso-IS1N protein InsA 4246204..4246476 Shigella dysenteriae Sd197 18263201 YP_405903.1 CDS SDY_4540 NC_007606.1 4246503 4246898 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4246503..4246898 Shigella dysenteriae Sd197 3795543 YP_405904.1 CDS yhjC NC_007606.1 4247198 4248073 D Code: K; COG: COG0583; LysR family transcriptional regulator 4247198..4248073 Shigella dysenteriae Sd197 3795544 YP_405905.1 CDS yhjD NC_007606.1 4248122 4249135 D Code: S; COG: COG1295; hypothetical protein 4248122..4249135 Shigella dysenteriae Sd197 3795545 YP_405906.1 CDS yhjE NC_007606.1 4249527 4250849 D Code: GEPR; COG: COG0477; transport protein 4249527..4250849 Shigella dysenteriae Sd197 3795546 YP_405907.1 CDS yhjG NC_007606.1 4251031 4253106 R Code: M; COG: COG2982; hypothetical protein complement(4251031..4253106) Shigella dysenteriae Sd197 3795547 YP_405908.1 CDS yhjH NC_007606.1 4253161 4253931 R in Escherichia coli this protein is involved in flagellar function; diguanylate phosphodiesterase complement(4253161..4253931) Shigella dysenteriae Sd197 3795548 YP_009000888.1 CDS SDY_4546 NC_007606.1 4254160 4255089 D ketodeoxygluconokinase 4254160..4255089 Shigella dysenteriae Sd197 3795549 YP_405909.1 CDS yhjJ NC_007606.1 4255185 4256681 R Code: R; COG: COG0612; hypothetical protein complement(4255185..4256681) Shigella dysenteriae Sd197 3795550 YP_405910.1 CDS dctA NC_007606.1 4256902 4258188 R involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA complement(4256902..4258188) Shigella dysenteriae Sd197 3795551 YP_405911.1 CDS yhjK NC_007606.1 4258371 4260326 R HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli; phosphodiesterase complement(4258371..4260326) Shigella dysenteriae Sd197 3795552 YP_405912.1 CDS yhjN NC_007606.1 4265009 4267348 R ''binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP)''; cellulose synthase regulator protein complement(4265009..4267348) Shigella dysenteriae Sd197 3795555 YP_405913.2 CDS bcsA NC_007606.1 4267359 4269977 R ''polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis''; cellulose synthase catalytic subunit complement(4267359..4269977) Shigella dysenteriae Sd197 3795556 YP_405914.1 CDS yhjR NC_007606.1 4270738 4270926 R hypothetical protein complement(4270738..4270926) Shigella dysenteriae Sd197 3795653 YP_405915.1 CDS SDY_4557 NC_007606.1 4271658 4272035 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4271658..4272035) Shigella dysenteriae Sd197 3795308 YP_405916.1 CDS SDY_4558 NC_007606.1 4272080 4272355 R Code: L; COG: COG3677; insertion element IS1 protein InsA complement(4272080..4272355) Shigella dysenteriae Sd197 3795309 YP_405917.1 CDS SDY_4559 NC_007606.1 4272464 4272859 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4272464..4272859) Shigella dysenteriae Sd197 3795655 YP_009000889.1 CDS SDY_4560 NC_007606.1 4276254 4276451 R small toxic polypeptide complement(4276254..4276451) Shigella dysenteriae Sd197 3795656 YP_405919.1 CDS yhjV NC_007606.1 4276837 4278108 D Code: E; COG: COG0814; transporter protein 4276837..4278108 Shigella dysenteriae Sd197 3795658 YP_405920.1 CDS dppF NC_007606.1 4278138 4279142 R Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide ABC transporter ATP-binding protein complement(4278138..4279142) Shigella dysenteriae Sd197 3795659 YP_405921.1 CDS dppD NC_007606.1 4279139 4280122 R DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide ABC transporter ATP-binding protein complement(4279139..4280122) Shigella dysenteriae Sd197 3795660 YP_405922.1 CDS dppC NC_007606.1 4280133 4281035 R Code: EP; COG: COG1173; dipeptide transporter complement(4280133..4281035) Shigella dysenteriae Sd197 3795661 YP_405923.1 CDS dppB NC_007606.1 4281045 4282064 R transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB complement(4281045..4282064) Shigella dysenteriae Sd197 3795662 YP_405924.1 CDS dppA NC_007606.1 4282215 4283822 R Code: E; COG: COG0747; dipeptide transport protein complement(4282215..4283822) Shigella dysenteriae Sd197 3795663 YP_405925.1 CDS SDY_4570 NC_007606.1 4285579 4286790 R hypothetical protein complement(4285579..4286790) Shigella dysenteriae Sd197 3795666 YP_405926.2 CDS SDY_4571 NC_007606.1 4286802 4287707 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(4286802..4287707) Shigella dysenteriae Sd197 3795667 YP_405927.1 CDS SDY_4572 NC_007606.1 4287665 4288030 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA complement(4287665..4288030) Shigella dysenteriae Sd197 3795668 YP_405929.1 CDS SDY_4574 NC_007606.1 4288450 4289163 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 4288450..4289163 Shigella dysenteriae Sd197 3795670 YP_405930.1 CDS SDY_4576 NC_007606.1 4292076 4292471 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4292076..4292471) Shigella dysenteriae Sd197 3795578 YP_009000890.1 CDS SDY_4813 NC_007606.1 4292498 4292770 R insertion element iso-IS1N protein InsA complement(4292498..4292770) Shigella dysenteriae Sd197 18263202 YP_405932.1 CDS SDY_4580 NC_007606.1 4293697 4294050 D hypothetical protein 4293697..4294050 Shigella dysenteriae Sd197 3795582 YP_405933.1 CDS SDY_4581 NC_007606.1 4294119 4294394 D Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 4294119..4294394 Shigella dysenteriae Sd197 3795310 YP_405934.1 CDS SDY_4582 NC_007606.1 4294439 4294816 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4294439..4294816 Shigella dysenteriae Sd197 3795311 YP_405936.1 CDS SDY_4584 NC_007606.1 4294974 4295339 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 4294974..4295339 Shigella dysenteriae Sd197 3795584 YP_405937.2 CDS SDY_4585 NC_007606.1 4295297 4296202 D IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4295297..4296202 Shigella dysenteriae Sd197 3795585 YP_405938.1 CDS SDY_4586 NC_007606.1 4296302 4297066 D Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 4296302..4297066 Shigella dysenteriae Sd197 3795586 YP_405940.1 CDS SDY_4589 NC_007606.1 4300128 4300601 D hypothetical protein 4300128..4300601 Shigella dysenteriae Sd197 3795589 YP_405941.1 CDS SDY_4590 NC_007606.1 4300617 4301093 D Code: L; COG: COG2003; DNA repair protein 4300617..4301093 Shigella dysenteriae Sd197 3795590 YP_405942.1 CDS SDY_4591 NC_007606.1 4301162 4301383 D hypothetical protein 4301162..4301383 Shigella dysenteriae Sd197 3795591 YP_009000891.1 CDS SDY_4591a NC_007606.1 4301546 4301914 D cytoskeleton bundling-enhancing factor A 4301546..4301914 Shigella dysenteriae Sd197 18263203 YP_405943.1 CDS SDY_4592 NC_007606.1 4302375 4302866 D hypothetical protein 4302375..4302866 Shigella dysenteriae Sd197 3795592 YP_009000892.1 CDS SDY_4814 NC_007606.1 4303990 4304262 D insertion element iso-IS1N protein InsA 4303990..4304262 Shigella dysenteriae Sd197 18263204 YP_405946.1 CDS SDY_4595 NC_007606.1 4304805 4305062 R hypothetical protein complement(4304805..4305062) Shigella dysenteriae Sd197 3795595 YP_405947.1 CDS yjiL NC_007606.1 4305059 4305832 R activator of (R)-hydroxyglutaryl-CoA dehydratase; ATPase complement(4305059..4305832) Shigella dysenteriae Sd197 3795314 YP_405948.1 CDS yjiO NC_007606.1 4308424 4309656 R Code: GEPR; COG: COG0477; transport protein complement(4308424..4309656) Shigella dysenteriae Sd197 3795317 YP_405949.1 CDS SDY_4600 NC_007606.1 4310123 4311067 D Code: S; COG: COG5464; hypothetical protein 4310123..4311067 Shigella dysenteriae Sd197 3795318 YP_405950.1 CDS yjiR NC_007606.1 4311310 4312722 R Code: KE; COG: COG1167; regulator complement(4311310..4312722) Shigella dysenteriae Sd197 3795319 YP_405951.1 CDS yjiS NC_007606.1 4312899 4313063 D Code: S; COG: COG5457; hypothetical protein 4312899..4313063 Shigella dysenteriae Sd197 3795320 YP_405953.1 CDS SDY_4604 NC_007606.1 4313365 4313760 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4313365..4313760) Shigella dysenteriae Sd197 3795322 YP_009000893.1 CDS SDY_4815 NC_007606.1 4313787 4314059 R insertion element iso-IS1N protein InsA complement(4313787..4314059) Shigella dysenteriae Sd197 18263205 YP_405954.1 CDS yjiA NC_007606.1 4314122 4314976 R Code: R; COG: COG0523; GTP-binding protein YjiA complement(4314122..4314976) Shigella dysenteriae Sd197 3795323 YP_405955.1 CDS yjiX NC_007606.1 4315089 4315292 R Code: S; COG: COG2879; hypothetical protein complement(4315089..4315292) Shigella dysenteriae Sd197 3795324 YP_405956.1 CDS yjiY NC_007606.1 4315423 4317588 R Code: T; COG: COG1966; carbon starvation protein complement(4315423..4317588) Shigella dysenteriae Sd197 3795325 YP_405957.1 CDS SDY_4609 NC_007606.1 4320060 4320362 D Code: L; COG: COG2963; insertion sequence element IS600 transposase 4320060..4320362 Shigella dysenteriae Sd197 3795327 YP_405959.2 CDS mdoB NC_007606.1 4322255 4324546 R catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I complement(4322255..4324546) Shigella dysenteriae Sd197 3795331 YP_405960.1 CDS yjjA NC_007606.1 4324800 4325297 R hypothetical protein complement(4324800..4325297) Shigella dysenteriae Sd197 3795332 YP_405961.1 CDS dnaC NC_007606.1 4325343 4326080 R initiation and chain elongation; acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC complement(4325343..4326080) Shigella dysenteriae Sd197 3795372 YP_405962.1 CDS dnaT NC_007606.1 4326083 4326622 R primosomal protein i; ''This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'''; primosomal protein DnaI complement(4326083..4326622) Shigella dysenteriae Sd197 3795373 YP_405963.2 CDS yjjB NC_007606.1 4326729 4327202 R Code: S; COG: COG3610; hypothetical protein complement(4326729..4327202) Shigella dysenteriae Sd197 3795374 YP_405964.1 CDS SDY_4618 NC_007606.1 4328009 4328284 D Code: L; COG: COG3677; insertion element IS1 protein InsA 4328009..4328284 Shigella dysenteriae Sd197 3795312 YP_405965.1 CDS SDY_4619 NC_007606.1 4328329 4328706 D Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4328329..4328706 Shigella dysenteriae Sd197 3795313 YP_405966.1 CDS SDY_4621 NC_007606.1 4329068 4329463 R Code: L; COG: COG1662; insertion element iso-IS1n protein InsB complement(4329068..4329463) Shigella dysenteriae Sd197 3795376 YP_009000894.1 CDS SDY_4816 NC_007606.1 4329490 4329762 R insertion element iso-IS1N protein InsA complement(4329490..4329762) Shigella dysenteriae Sd197 18263206 YP_009000895.1 CDS SDY_4817 NC_007606.1 4330439 4330735 D insertion element iso-IS1N protein InsA 4330439..4330735 Shigella dysenteriae Sd197 18263207 YP_405967.1 CDS SDY_4623 NC_007606.1 4330737 4331132 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4330737..4331132 Shigella dysenteriae Sd197 3795378 YP_405968.1 CDS fhuF NC_007606.1 4332304 4333092 R Code: R; COG: COG4114; ferric hydroximate transport ferric iron reductase complement(4332304..4333092) Shigella dysenteriae Sd197 3795380 YP_405969.2 CDS SDY_4626 NC_007606.1 4333233 4333469 D hypothetical protein 4333233..4333469 Shigella dysenteriae Sd197 3795381 YP_405970.1 CDS rsmC NC_007606.1 4334031 4335062 R 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase complement(4334031..4335062) Shigella dysenteriae Sd197 3795385 YP_405971.1 CDS holD NC_007606.1 4335165 4335578 D with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 4335165..4335578 Shigella dysenteriae Sd197 3795386 YP_405972.1 CDS rimI NC_007606.1 4335547 4335993 D acetylation of N-terminal alanine; alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 4335547..4335993 Shigella dysenteriae Sd197 3795387 YP_405973.1 CDS yjjG NC_007606.1 4336008 4336685 D ''manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily''; nucleotidase 4336008..4336685 Shigella dysenteriae Sd197 3795333 YP_405974.1 CDS prfC NC_007606.1 4336776 4338365 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 4336776..4338365 Shigella dysenteriae Sd197 3795334 YP_009000896.1 CDS SDY_4818 NC_007606.1 4338484 4338756 D insertion element iso-IS1N protein InsA 4338484..4338756 Shigella dysenteriae Sd197 18263208 YP_405975.1 CDS SDY_4635 NC_007606.1 4338783 4339178 D Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4338783..4339178 Shigella dysenteriae Sd197 3795335 YP_405976.1 CDS osmY NC_007606.1 4339532 4340137 D Code: R; COG: COG2823; hypothetical protein 4339532..4340137 Shigella dysenteriae Sd197 3795336 YP_009000897.1 CDS SDY_4636a NC_007606.1 4340264 4340425 D hypothetical protein 4340264..4340425 Shigella dysenteriae Sd197 18263209 YP_405977.1 CDS yjjU NC_007606.1 4340547 4341620 D Code: R; COG: COG4667; hypothetical protein 4340547..4341620 Shigella dysenteriae Sd197 3795337 YP_405978.1 CDS yjjV NC_007606.1 4341617 4342399 D Code: L; COG: COG0084; deoxyribonuclease YjjV 4341617..4342399 Shigella dysenteriae Sd197 3795338 YP_405979.1 CDS yjjW NC_007606.1 4342612 4343475 R Code: O; COG: COG1180; activating enzyme complement(4342612..4343475) Shigella dysenteriae Sd197 3795339 YP_405980.1 CDS yjjI NC_007606.1 4343447 4344997 R hypothetical protein complement(4343447..4344997) Shigella dysenteriae Sd197 3795340 YP_405981.1 CDS deoC NC_007606.1 4345255 4346034 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 4345255..4346034 Shigella dysenteriae Sd197 3795341 YP_405982.1 CDS deoA NC_007606.1 4346161 4347483 D ''Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate''; thymidine phosphorylase 4346161..4347483 Shigella dysenteriae Sd197 3795342 YP_405983.1 CDS deoB NC_007606.1 4347535 4348758 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 4347535..4348758 Shigella dysenteriae Sd197 3795343 YP_405984.1 CDS deoD NC_007606.1 4348838 4349557 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 4348838..4349557 Shigella dysenteriae Sd197 3795344 YP_009000898.1 CDS SDY_4819 NC_007606.1 4349760 4350032 D insertion element iso-IS1N protein InsA 4349760..4350032 Shigella dysenteriae Sd197 18263210 YP_405985.1 CDS SDY_4645 NC_007606.1 4350059 4350454 D Code: L; COG: COG1662; insertion element IS1 protein InsB 4350059..4350454 Shigella dysenteriae Sd197 3795345 YP_405986.1 CDS SDY_4646 NC_007606.1 4350492 4350755 R Code: K; COG: COG1396; hypothetical protein complement(4350492..4350755) Shigella dysenteriae Sd197 3795346 YP_405987.1 CDS lplA NC_007606.1 4350787 4351803 R Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A complement(4350787..4351803) Shigella dysenteriae Sd197 3795347 YP_405988.1 CDS smp NC_007606.1 4351831 4352475 R Code: R; COG: COG3726; hypothetical protein complement(4351831..4352475) Shigella dysenteriae Sd197 3795348 YP_405989.1 CDS serB NC_007606.1 4352581 4353549 D catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 4352581..4353549 Shigella dysenteriae Sd197 3795349 YP_405990.1 CDS sms NC_007606.1 4353598 4354980 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4353598..4354980 Shigella dysenteriae Sd197 3795350 YP_405991.2 CDS nadR NC_007606.1 4355001 4356233 D catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 4355001..4356233 Shigella dysenteriae Sd197 3795351 YP_405992.1 CDS yjjK NC_007606.1 4356540 4358207 R ''ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence''; ABC transporter ATP-binding protein complement(4356540..4358207) Shigella dysenteriae Sd197 3795352 YP_405993.2 CDS slt NC_007606.1 4358418 4360355 D catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 4358418..4360355 Shigella dysenteriae Sd197 3795296 YP_405994.1 CDS trpR NC_007606.1 4360445 4360771 D trp aporepressor; When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 4360445..4360771 Shigella dysenteriae Sd197 3795297 YP_405995.2 CDS yjjX NC_007606.1 4360814 4361326 R pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase complement(4360814..4361326) Shigella dysenteriae Sd197 3795298 YP_405996.1 CDS gpmB NC_007606.1 4361378 4362025 D catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 4361378..4362025 Shigella dysenteriae Sd197 3795299 YP_405997.1 CDS rob NC_007606.1 4362022 4362891 R Code: K; COG: COG2207; right origin-binding protein complement(4362022..4362891) Shigella dysenteriae Sd197 3795300 YP_405998.1 CDS creA NC_007606.1 4363102 4363575 D Code: S; COG: COG3045; hypothetical protein 4363102..4363575 Shigella dysenteriae Sd197 3795301 YP_405999.1 CDS creB NC_007606.1 4363588 4364277 D response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 4363588..4364277 Shigella dysenteriae Sd197 3795302 YP_406000.1 CDS arcA NC_007606.1 4367170 4367886 R sensors, ArcB and CpxA; Code: TK; COG: COG0745; two-component response regulator complement(4367170..4367886) Shigella dysenteriae Sd197 3795305 YP_406001.1 CDS yjjY NC_007606.1 4367982 4368122 D hypothetical protein 4367982..4368122 Shigella dysenteriae Sd197 3795306 YP_406002.1 CDS lasT NC_007606.1 4368522 4369208 D member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 4368522..4369208 Shigella dysenteriae Sd197 3795307 YP_406003.1 CDS SDY_P002 NC_007607.1 191 367 R IS2 ORF2 complement(191..367) Shigella dysenteriae Sd197 3776545 YP_406004.1 CDS SDY_P001 NC_007607.1 359 823 D putative resolvase, fragment 359..823 Shigella dysenteriae Sd197 3776544 YP_406005.1 CDS ospB NC_007607.1 1233 1916 D protein secreted by the Mxi-Spa secretion machinery; OspB 1233..1916 Shigella dysenteriae Sd197 3776546 YP_406006.1 CDS phoN2/apy NC_007607.1 2244 2984 D periplasmic phosphatase, apyrase, ATP diphosphohydrolase; PhoN2/Apy 2244..2984 Shigella dysenteriae Sd197 3776547 YP_406007.1 CDS SDY_P005 NC_007607.1 4663 5058 D iso-IS1 ORF2 4663..5058 Shigella dysenteriae Sd197 3776548 YP_406008.1 CDS SDY_P007 NC_007607.1 5493 5894 R ISEc8 orf, fragment complement(5493..5894) Shigella dysenteriae Sd197 3776550 YP_406009.1 CDS SDY_P008 NC_007607.1 5974 6396 R IS600 ORF2 complement(5974..6396) Shigella dysenteriae Sd197 3776551 YP_406010.1 CDS SDY_P009 NC_007607.1 6432 6734 R IS600 ORF1 complement(6432..6734) Shigella dysenteriae Sd197 3776552 YP_406011.1 CDS ospD2 NC_007607.1 7424 9142 R probably secreted by the Mxi-Spa secretion machinery; OspD2 complement(7424..9142) Shigella dysenteriae Sd197 3776553 YP_406012.2 CDS SDY_P011 NC_007607.1 9498 10403 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(9498..10403) Shigella dysenteriae Sd197 3776554 YP_406013.1 CDS SDY_P012 NC_007607.1 10361 10726 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(10361..10726) Shigella dysenteriae Sd197 3776555 YP_406014.1 CDS ospF NC_007607.1 10901 11620 R secreted by the Mxi-Spa secretion machinery; OspF complement(10901..11620) Shigella dysenteriae Sd197 3776469 YP_406015.1 CDS SDY_P014 NC_007607.1 11826 12203 R putative transposase complement(11826..12203) Shigella dysenteriae Sd197 3776470 YP_406016.1 CDS SDY_P015 NC_007607.1 12740 13318 R hypothetical protein complement(12740..13318) Shigella dysenteriae Sd197 3776471 YP_406017.1 CDS SDY_P016 NC_007607.1 13547 13666 R IS3 orf2, fragment complement(13547..13666) Shigella dysenteriae Sd197 3776472 YP_406018.1 CDS SDY_P018 NC_007607.1 14289 14690 R IS91 orf complement(14289..14690) Shigella dysenteriae Sd197 3776474 YP_406019.1 CDS SDY_P017 NC_007607.1 14675 14962 D hypothetical protein 14675..14962 Shigella dysenteriae Sd197 3776473 YP_406020.1 CDS SDY_P019 NC_007607.1 15233 15640 D putative IS orf, fragment 15233..15640 Shigella dysenteriae Sd197 3776475 YP_406021.1 CDS SDY_P020 NC_007607.1 15640 15987 D ISSfl4 ORF2 15640..15987 Shigella dysenteriae Sd197 3776476 YP_406022.1 CDS SDY_P021 NC_007607.1 16115 17314 D putative IS orf, fragment 16115..17314 Shigella dysenteriae Sd197 3776477 YP_406023.1 CDS SDY_P022 NC_007607.1 18083 18289 D putative transposase, fragment 18083..18289 Shigella dysenteriae Sd197 3776478 YP_406024.1 CDS ospD1 NC_007607.1 18877 19554 D secreted by the Mxi-Spa secretion machinery; OspD1 18877..19554 Shigella dysenteriae Sd197 3776479 YP_406025.1 CDS SDY_P024 NC_007607.1 20036 20260 R hypothetical protein complement(20036..20260) Shigella dysenteriae Sd197 3776480 YP_406026.1 CDS ipgB2 NC_007607.1 20653 21228 D probably secreted by the Mxi-Spa secretion machinery; IpgB2 20653..21228 Shigella dysenteriae Sd197 3776481 YP_406027.1 CDS SDY_P026 NC_007607.1 21800 22099 D IS3 ORF1 21800..22099 Shigella dysenteriae Sd197 3776482 YP_406028.1 CDS SDY_P027 NC_007607.1 22096 22965 D IS3 ORF2 22096..22965 Shigella dysenteriae Sd197 3776483 YP_406029.1 CDS SDY_P028 NC_007607.1 23305 23577 D iso-IS1 ORF1 23305..23577 Shigella dysenteriae Sd197 3776484 YP_406030.1 CDS SDY_P029 NC_007607.1 23820 24908 D IS100 ORF1 23820..24908 Shigella dysenteriae Sd197 3776485 YP_406031.1 CDS SDY_P030 NC_007607.1 24880 25521 D transposase/IS protein 24880..25521 Shigella dysenteriae Sd197 3776486 YP_406032.1 CDS parA NC_007607.1 26268 27467 D plasmid segregation protein 26268..27467 Shigella dysenteriae Sd197 3776487 YP_406033.1 CDS parB NC_007607.1 27467 28447 D plasmid segregation protein 27467..28447 Shigella dysenteriae Sd197 3776631 YP_406034.1 CDS SDY_P033 NC_007607.1 28703 29188 D putative transposase, fragment 28703..29188 Shigella dysenteriae Sd197 3776632 YP_406035.1 CDS SDY_P034 NC_007607.1 29477 30604 R putative reverse transcriptase complement(29477..30604) Shigella dysenteriae Sd197 3776633 YP_406036.1 CDS SDY_P035 NC_007607.1 31384 32007 R IS629 ORF2 complement(31384..32007) Shigella dysenteriae Sd197 3776634 YP_406037.1 CDS SDY_P036 NC_007607.1 32204 32524 D hypothetical protein 32204..32524 Shigella dysenteriae Sd197 3776635 YP_406038.1 CDS ipaH4.5 NC_007607.1 32657 34381 R probably secreted by the Mxi-Spa machinery; invasion plasmid antigen complement(32657..34381) Shigella dysenteriae Sd197 3776636 YP_406039.1 CDS ipaH7.8 NC_007607.1 34809 36506 R probably secreted by the Mxi-Spa machinery; invasion plasmid antigen complement(34809..36506) Shigella dysenteriae Sd197 3776637 YP_406040.1 CDS SDY_P039 NC_007607.1 37326 37700 R IS600 ORF2 complement(37326..37700) Shigella dysenteriae Sd197 3776638 YP_406041.1 CDS SDY_P040 NC_007607.1 37678 38133 R IS600 ORF2 complement(37678..38133) Shigella dysenteriae Sd197 3776639 YP_406042.1 CDS insB NC_007607.1 38236 38613 R IS1 ORF2 complement(38236..38613) Shigella dysenteriae Sd197 3776640 YP_406043.1 CDS SDY_P042 NC_007607.1 39246 39695 D ISSfl1 ORF1 39246..39695 Shigella dysenteriae Sd197 3776641 YP_406044.1 CDS SDY_P043 NC_007607.1 39701 40090 D ISSfl1 ORF2 39701..40090 Shigella dysenteriae Sd197 3776642 YP_406045.1 CDS SDY_P044 NC_007607.1 40229 40396 D hypothetical protein 40229..40396 Shigella dysenteriae Sd197 3776643 YP_406046.1 CDS ipaH1.4 NC_007607.1 40414 42162 R secreted by the Mxi-Spa secretion machinery; invasion plasmid antigen complement(40414..42162) Shigella dysenteriae Sd197 3776644 YP_406047.1 CDS ospE1 NC_007607.1 42529 42795 R secreted by the Mxi-Spa secretion machinery; OspE1 complement(42529..42795) Shigella dysenteriae Sd197 3776645 YP_406048.1 CDS SDY_P047 NC_007607.1 42851 43135 R IS1 ORF, fragment complement(42851..43135) Shigella dysenteriae Sd197 3776646 YP_406049.1 CDS SDY_P048 NC_007607.1 43633 43935 D IS600 ORF1 43633..43935 Shigella dysenteriae Sd197 3776647 YP_406050.1 CDS SDY_P049 NC_007607.1 44084 44479 R iso-IS1 ORF2 complement(44084..44479) Shigella dysenteriae Sd197 3776466 YP_406051.1 CDS SDY_P050 NC_007607.1 44506 44778 R iso-IS1 ORF1 complement(44506..44778) Shigella dysenteriae Sd197 3776467 YP_406052.1 CDS SDY_P051 NC_007607.1 44973 45620 R IS629 ORF2 complement(44973..45620) Shigella dysenteriae Sd197 3776468 YP_406053.1 CDS SDY_P052 NC_007607.1 45781 46101 D hypothetical protein 45781..46101 Shigella dysenteriae Sd197 3776556 YP_406054.1 CDS SDY_P053 NC_007607.1 46208 46537 R putative transposase complement(46208..46537) Shigella dysenteriae Sd197 3776648 YP_406055.1 CDS SDY_P054 NC_007607.1 46613 46786 R hypothetical protein complement(46613..46786) Shigella dysenteriae Sd197 3776649 YP_406056.1 CDS ospC1 NC_007607.1 47797 49209 D secreted by the Mxi-Spa secretion machinery; OspC1 47797..49209 Shigella dysenteriae Sd197 3776650 YP_406057.1 CDS ospD3 NC_007607.1 49566 51215 D SenA; probably secreted by the Mxi-Spa secretion machinery; OspD3 49566..51215 Shigella dysenteriae Sd197 3776651 YP_406058.1 CDS SDY_P057 NC_007607.1 51512 51907 R iso-IS1 ORF2 complement(51512..51907) Shigella dysenteriae Sd197 3776652 YP_406059.1 CDS SDY_P058 NC_007607.1 51934 52206 R iso-IS1 ORF1 complement(51934..52206) Shigella dysenteriae Sd197 3776653 YP_406060.1 CDS SDY_P059 NC_007607.1 52421 52549 D putative transposase, fragment 52421..52549 Shigella dysenteriae Sd197 3776654 YP_406061.1 CDS SDY_P060 NC_007607.1 52645 53223 D putative transposase 52645..53223 Shigella dysenteriae Sd197 3776655 YP_406062.1 CDS SDY_P061 NC_007607.1 53208 53498 D hypothetical protein 53208..53498 Shigella dysenteriae Sd197 3776656 YP_406063.1 CDS SDY_P063 NC_007607.1 53802 54053 R hypothetical protein complement(53802..54053) Shigella dysenteriae Sd197 3776658 YP_406064.1 CDS SDY_P062 NC_007607.1 54044 54934 D IS629 ORF2 54044..54934 Shigella dysenteriae Sd197 3776657 YP_406065.1 CDS ushA NC_007607.1 55224 56927 D probable periplasmic UDP-sugar hydrolase; catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor 55224..56927 Shigella dysenteriae Sd197 3776659 YP_406066.1 CDS SDY_P065 NC_007607.1 56996 57268 D iso-IS1 ORF1 56996..57268 Shigella dysenteriae Sd197 3776660 YP_406067.1 CDS SDY_P066 NC_007607.1 57295 57690 D iso-IS1 ORF2 57295..57690 Shigella dysenteriae Sd197 3776661 YP_406068.1 CDS phoN1 NC_007607.1 58105 58854 D periplasmic non specific acid ohosphatase; PhoN1 58105..58854 Shigella dysenteriae Sd197 3776662 YP_406069.1 CDS SDY_P068 NC_007607.1 59024 59413 R ISSfl1 ORF2 complement(59024..59413) Shigella dysenteriae Sd197 3776663 YP_406070.1 CDS SDY_P069 NC_007607.1 59419 59643 R ISSfl1 ORF1 complement(59419..59643) Shigella dysenteriae Sd197 3776664 YP_406071.1 CDS ospC2 NC_007607.1 60293 61747 D probably secreted by the Mxi-Spa secretion machinery; OspC2 60293..61747 Shigella dysenteriae Sd197 3776665 YP_406072.1 CDS SDY_P071 NC_007607.1 61897 62286 R ISSfl1 ORF2 complement(61897..62286) Shigella dysenteriae Sd197 3776573 YP_406073.1 CDS SDY_P072 NC_007607.1 62292 62741 R ISSfl1 ORF1 complement(62292..62741) Shigella dysenteriae Sd197 3776574 YP_406074.1 CDS SDY_P073 NC_007607.1 62787 63161 R hypothetical protein complement(62787..63161) Shigella dysenteriae Sd197 3776575 YP_406075.1 CDS stbB NC_007607.1 63347 63742 R plasmid stable inheritance protein complement(63347..63742) Shigella dysenteriae Sd197 3776576 YP_406076.1 CDS stbA NC_007607.1 63742 64701 R plasmid stable inheritance protein complement(63742..64701) Shigella dysenteriae Sd197 3776577 YP_406077.1 CDS SDY_P076 NC_007607.1 65116 65511 D hypothetical protein 65116..65511 Shigella dysenteriae Sd197 3776578 YP_406078.1 CDS SDY_P077 NC_007607.1 65508 66221 R IS600 ORF2 complement(65508..66221) Shigella dysenteriae Sd197 3776579 YP_406079.1 CDS insB NC_007607.1 66288 66665 R IS1 ORF2 complement(66288..66665) Shigella dysenteriae Sd197 3776580 YP_406080.1 CDS SDY_P079 NC_007607.1 67139 67441 R IS600 ORF1 complement(67139..67441) Shigella dysenteriae Sd197 3776581 YP_406081.1 CDS SDY_P080 NC_007607.1 67698 67853 R hypothetical protein complement(67698..67853) Shigella dysenteriae Sd197 3776582 YP_406082.1 CDS SDY_P081 NC_007607.1 68076 68294 R IS2 orf1, fragment complement(68076..68294) Shigella dysenteriae Sd197 3776583 YP_406083.1 CDS SDY_P082 NC_007607.1 68349 68987 R hypothetical protein complement(68349..68987) Shigella dysenteriae Sd197 3776584 YP_406084.1 CDS SDY_P083 NC_007607.1 69343 69615 R iso-IS1 ORF1 complement(69343..69615) Shigella dysenteriae Sd197 3776585 YP_406085.1 CDS SDY_P084 NC_007607.1 69951 70184 D IS100 ORF2 69951..70184 Shigella dysenteriae Sd197 3776586 YP_406086.1 CDS SDY_P085 NC_007607.1 70236 70526 R hypothetical protein complement(70236..70526) Shigella dysenteriae Sd197 3776587 YP_406087.1 CDS SDY_P086 NC_007607.1 70533 70745 R hypothetical protein complement(70533..70745) Shigella dysenteriae Sd197 3776588 YP_406088.1 CDS SDY_P087 NC_007607.1 71197 71481 D hypothetical protein 71197..71481 Shigella dysenteriae Sd197 3776589 YP_406089.1 CDS SDY_P088 NC_007607.1 71481 71756 D hypothetical protein 71481..71756 Shigella dysenteriae Sd197 3776590 YP_406090.1 CDS SDY_P089 NC_007607.1 71809 71982 D hypothetical protein 71809..71982 Shigella dysenteriae Sd197 3776591 YP_406091.1 CDS SDY_P090 NC_007607.1 72117 72482 R plasmid stable inheritance protein complement(72117..72482) Shigella dysenteriae Sd197 3776592 YP_406092.1 CDS SDY_P092 NC_007607.1 72514 73011 R putative plasmid stable inheritance protein complement(72514..73011) Shigella dysenteriae Sd197 3776594 YP_406093.1 CDS SDY_P091 NC_007607.1 73010 73771 D putative IS orf, fragment 73010..73771 Shigella dysenteriae Sd197 3776593 YP_406094.1 CDS SDY_P093 NC_007607.1 73771 74151 D putative IS orf, fragment 73771..74151 Shigella dysenteriae Sd197 3776595 YP_406095.1 CDS SDY_P094 NC_007607.1 74527 74742 R iso-IS1 ORF2 complement(74527..74742) Shigella dysenteriae Sd197 3776596 YP_406096.1 CDS SDY_P095 NC_007607.1 74948 75220 R iso-IS1 ORF1 complement(74948..75220) Shigella dysenteriae Sd197 3776597 YP_406097.1 CDS ccdA NC_007607.1 75460 75678 D plasmid maintenance protein CcdA 75460..75678 Shigella dysenteriae Sd197 3776598 YP_406098.1 CDS ccdB NC_007607.1 75680 75985 D controlled cell death protein; post-segregation toxin; toxin addiction system; plasmid maintenance protein CcdB 75680..75985 Shigella dysenteriae Sd197 3776599 YP_406099.1 CDS SDY_P098 NC_007607.1 76543 76938 D iso-IS1 ORF2 76543..76938 Shigella dysenteriae Sd197 3776600 YP_406100.1 CDS ipaH9.8 NC_007607.1 77122 78789 D secreted by the Mxi-Spa secretion machinery; invasion plasmid antigen 77122..78789 Shigella dysenteriae Sd197 3776601 YP_406101.1 CDS yacA NC_007607.1 78997 79266 D hypothetical protein 78997..79266 Shigella dysenteriae Sd197 3776602 YP_406102.1 CDS ospG NC_007607.1 79518 80108 D secreted by the Mxi-Spa secretion machinery; OspG 79518..80108 Shigella dysenteriae Sd197 3776603 YP_406103.1 CDS SDY_P102 NC_007607.1 80513 80755 D putative IS orf 80513..80755 Shigella dysenteriae Sd197 3776604 YP_406104.1 CDS SDY_P103 NC_007607.1 80794 82140 D IS4 orf 80794..82140 Shigella dysenteriae Sd197 3776605 YP_406105.1 CDS SDY_P104 NC_007607.1 82151 82393 R putative IS orf complement(82151..82393) Shigella dysenteriae Sd197 3776606 YP_406106.1 CDS SDY_P105 NC_007607.1 82491 82709 D IS3 ORF2 82491..82709 Shigella dysenteriae Sd197 3776607 YP_406107.1 CDS SDY_P106 NC_007607.1 82697 85546 R hypothetical protein complement(82697..85546) Shigella dysenteriae Sd197 3776608 YP_406108.1 CDS shf NC_007607.1 86143 86934 D putative carbohydrate transport protein 86143..86934 Shigella dysenteriae Sd197 3776609 YP_406109.1 CDS rfbU NC_007607.1 87084 88025 D UDP-sugar hydrolase 87084..88025 Shigella dysenteriae Sd197 3776610 YP_406110.1 CDS virK NC_007607.1 88030 88980 D required for proper localization of IcsA (VirG) at the surface of bacteria; VirK 88030..88980 Shigella dysenteriae Sd197 3776611 YP_406111.1 CDS msbB2 NC_007607.1 89045 89989 D probable lipid A transacetylase; Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 89045..89989 Shigella dysenteriae Sd197 3776666 YP_406112.1 CDS SDY_P111 NC_007607.1 90163 90831 D putative transposase 90163..90831 Shigella dysenteriae Sd197 3776667 YP_406113.1 CDS SDY_P112 NC_007607.1 90973 91281 R hypothetical protein complement(90973..91281) Shigella dysenteriae Sd197 3776668 YP_406114.1 CDS SDY_P113 NC_007607.1 91342 91545 R hypothetical protein complement(91342..91545) Shigella dysenteriae Sd197 3776669 YP_406115.1 CDS SDY_P114 NC_007607.1 91637 92329 D IS186 ORF1 91637..92329 Shigella dysenteriae Sd197 3776670 YP_406116.1 CDS SDY_P115 NC_007607.1 92370 93083 R IS600 ORF2 complement(92370..93083) Shigella dysenteriae Sd197 3776671 YP_406117.1 CDS SDY_P116 NC_007607.1 93224 93526 R IS600 ORF1 complement(93224..93526) Shigella dysenteriae Sd197 3776672 YP_406118.1 CDS traD NC_007607.1 93565 95079 D hypothetical protein 93565..95079 Shigella dysenteriae Sd197 3776673 YP_406119.1 CDS SDY_P118 NC_007607.1 94961 95374 D hypothetical protein 94961..95374 Shigella dysenteriae Sd197 3776674 YP_406120.1 CDS trbH NC_007607.1 95374 96093 D TrbH 95374..96093 Shigella dysenteriae Sd197 3776675 YP_406121.1 CDS mvpT NC_007607.1 95781 96008 R plasmid maintenance protein complement(95781..96008) Shigella dysenteriae Sd197 3776676 YP_406122.1 CDS SDY_P121 NC_007607.1 96090 96509 D oriT nicking and unwinding protein, fragment 96090..96509 Shigella dysenteriae Sd197 3776677 YP_406123.1 CDS SDY_P122 NC_007607.1 96517 100710 D cleaves origin of transfer and unwinds; oriT relaxase; conjugal transfer nickase/helicase TraI 96517..100710 Shigella dysenteriae Sd197 3776678 YP_406124.1 CDS SDY_P123 NC_007607.1 100659 101351 D putative DNA helicase I, fragment 100659..101351 Shigella dysenteriae Sd197 3776679 YP_406125.1 CDS traX NC_007607.1 101371 102117 D conjugal transfer pilus acetylation protein TraX 101371..102117 Shigella dysenteriae Sd197 3776680 YP_406126.1 CDS finO NC_007607.1 102172 102732 D putative fertility inhibition protein; conjugal transfer fertility inhibition protein FinO 102172..102732 Shigella dysenteriae Sd197 3776681 YP_406127.1 CDS yigA NC_007607.1 102863 103075 D hypothetical protein 102863..103075 Shigella dysenteriae Sd197 3776682 YP_406128.1 CDS SDY_P127 NC_007607.1 103259 103561 D hypothetical protein 103259..103561 Shigella dysenteriae Sd197 3776683 YP_406129.1 CDS insB NC_007607.1 103496 103741 R IS1 ORF2 complement(103496..103741) Shigella dysenteriae Sd197 3776684 YP_406130.1 CDS SDY_P129 NC_007607.1 104009 104221 R putative iso-IS1 orf complement(104009..104221) Shigella dysenteriae Sd197 3776685 YP_406131.1 CDS SDY_P130 NC_007607.1 104290 104520 D hypothetical protein 104290..104520 Shigella dysenteriae Sd197 3776612 YP_406132.1 CDS hmo NC_007607.1 104623 104811 D putative regulator 104623..104811 Shigella dysenteriae Sd197 3776613 YP_406133.1 CDS SDY_P132 NC_007607.1 104850 104963 D hypothetical protein 104850..104963 Shigella dysenteriae Sd197 3776614 YP_406134.1 CDS SDY_P133 NC_007607.1 104960 105355 R iso-IS1 ORF2 complement(104960..105355) Shigella dysenteriae Sd197 3776615 YP_406135.1 CDS SDY_P134 NC_007607.1 105382 105654 R iso-IS1 ORF1 complement(105382..105654) Shigella dysenteriae Sd197 3776616 YP_406136.1 CDS yihA NC_007607.1 105714 106214 D hypothetical protein 105714..106214 Shigella dysenteriae Sd197 3776617 YP_406137.1 CDS repB NC_007607.1 106454 106714 D replication protein 106454..106714 Shigella dysenteriae Sd197 3776618 YP_406138.1 CDS repA NC_007607.1 107005 107862 D RepA; replication protein 107005..107862 Shigella dysenteriae Sd197 3776619 YP_406139.1 CDS SDY_P138 NC_007607.1 108605 108700 D hypothetical protein 108605..108700 Shigella dysenteriae Sd197 3776620 YP_406140.1 CDS SDY_P139 NC_007607.1 108972 110180 R IS1294 transposase complement(108972..110180) Shigella dysenteriae Sd197 3776621 YP_406141.1 CDS SDY_P141 NC_007607.1 110161 110433 R hypothetical protein complement(110161..110433) Shigella dysenteriae Sd197 3776623 YP_406142.1 CDS ipaH NC_007607.1 110427 111971 D invasion plasmid antigen, fragment 110427..111971 Shigella dysenteriae Sd197 3776622 YP_406143.1 CDS SDY_P142 NC_007607.1 112011 112199 R IS600 ORF2 complement(112011..112199) Shigella dysenteriae Sd197 3776624 YP_406144.1 CDS SDY_P143 NC_007607.1 112235 112537 R IS600 ORF1 complement(112235..112537) Shigella dysenteriae Sd197 3776625 YP_406145.1 CDS SDY_P144 NC_007607.1 112605 113087 R hypothetical protein complement(112605..113087) Shigella dysenteriae Sd197 3776626 YP_406146.1 CDS SDY_P145 NC_007607.1 113078 113368 R hypothetical protein complement(113078..113368) Shigella dysenteriae Sd197 3776627 YP_406147.1 CDS SDY_P146 NC_007607.1 113794 114456 R transposase/IS protein complement(113794..114456) Shigella dysenteriae Sd197 3776628 YP_406148.1 CDS SDY_P147 NC_007607.1 114511 115803 R IS1294 transposase complement(114511..115803) Shigella dysenteriae Sd197 3776629 YP_406149.1 CDS SDY_P148 NC_007607.1 115784 116056 R hypothetical protein complement(115784..116056) Shigella dysenteriae Sd197 3776630 YP_406150.1 CDS SDY_P149 NC_007607.1 116076 116663 R ISSfl4 ORF1 complement(116076..116663) Shigella dysenteriae Sd197 3776686 YP_406151.1 CDS SDY_P150 NC_007607.1 116800 116973 R hypothetical protein complement(116800..116973) Shigella dysenteriae Sd197 3776687 YP_406152.1 CDS ospC3 NC_007607.1 117314 118768 D probably secreted by the Mxi-Spa secretion machinery; OspC3 117314..118768 Shigella dysenteriae Sd197 3776688 YP_406153.1 CDS SDY_P152 NC_007607.1 119107 119409 D IS600 ORF1 119107..119409 Shigella dysenteriae Sd197 3776689 YP_406154.1 CDS SDY_P153 NC_007607.1 119550 120263 D IS600 ORF2 119550..120263 Shigella dysenteriae Sd197 3776557 YP_406155.1 CDS SDY_P154 NC_007607.1 120388 120630 D IS1353 transposase 120388..120630 Shigella dysenteriae Sd197 3776558 YP_406156.1 CDS SDY_P155 NC_007607.1 120685 121038 D IS1353 transposase 120685..121038 Shigella dysenteriae Sd197 3776559 YP_406157.1 CDS SDY_P156 NC_007607.1 121228 122343 D putative transposase 121228..122343 Shigella dysenteriae Sd197 3776560 YP_406159.1 CDS SDY_P158 NC_007607.1 122432 123628 R ISSfl2 ORF complement(122432..123628) Shigella dysenteriae Sd197 3776562 YP_406160.1 CDS SDY_P159 NC_007607.1 123820 124746 R IS100 ORF1 complement(123820..124746) Shigella dysenteriae Sd197 3776563 YP_406161.1 CDS ipaJ NC_007607.1 126261 126944 D invasion plasmid antigen; IpaJ 126261..126944 Shigella dysenteriae Sd197 3776564 YP_406162.1 CDS virB NC_007607.1 127894 128823 R transcriptional activator required for tanscription of the ipa, mxi, and spa operons; VirB complement(127894..128823) Shigella dysenteriae Sd197 3776565 YP_406163.1 CDS acp NC_007607.1 129030 129266 R putative acyl carrier protein; Acp complement(129030..129266) Shigella dysenteriae Sd197 3776566 YP_406164.1 CDS ipaA NC_007607.1 129270 131171 R secreted by the Mxi-Spa machinery, modulates entry of bacteria into epithelial cells; IpaA complement(129270..131171) Shigella dysenteriae Sd197 3776567 YP_406165.1 CDS ipaD NC_007607.1 131180 132178 R secreted by the Mxi-Spa machinery, required for entry of bacteria into epithelial cells; IpaD complement(131180..132178) Shigella dysenteriae Sd197 3776568 YP_406166.1 CDS ipaC NC_007607.1 132229 133320 R secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells; IpaC complement(132229..133320) Shigella dysenteriae Sd197 3776569 YP_406167.1 CDS ipaB NC_007607.1 133340 135082 R secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells; IpaB complement(133340..135082) Shigella dysenteriae Sd197 3776570 YP_406168.1 CDS ipgC NC_007607.1 135088 135555 R cytoplasmic chaperone for IpaB and IpaC; IpgC complement(135088..135555) Shigella dysenteriae Sd197 3776571 YP_406169.1 CDS ipgB1 NC_007607.1 135613 136239 R secreted by the Mxi-Spa machinery; IpgB1 complement(135613..136239) Shigella dysenteriae Sd197 3776572 YP_406170.1 CDS ipgA NC_007607.1 136255 136644 R similar to IpgE, putative chaperone; IpgA complement(136255..136644) Shigella dysenteriae Sd197 3776525 YP_406171.1 CDS icsB NC_007607.1 136657 138141 R invasion protein; IcsB complement(136657..138141) Shigella dysenteriae Sd197 3776526 YP_406172.1 CDS ipgD NC_007607.1 138455 140071 D secreted by the Mxi-Spa machinery, modulates entry of bacteria into epithelial cells; IpgD 138455..140071 Shigella dysenteriae Sd197 3776527 YP_406173.1 CDS ipgE NC_007607.1 140081 140443 D cytoplasmic chaperone for IpgD; IpgE 140081..140443 Shigella dysenteriae Sd197 3776528 YP_406174.1 CDS ipgF NC_007607.1 140443 140901 D periplasmic protein, similar to the catalytic site of lyzozymes; IpgF 140443..140901 Shigella dysenteriae Sd197 3776529 YP_406175.1 CDS mxiG NC_007607.1 140910 142025 D component of the Mxi-Spa secretion machinery, contains one transmembrane segment; MxiG 140910..142025 Shigella dysenteriae Sd197 3776530 YP_406176.1 CDS mxiH NC_007607.1 142033 142284 D component of the Mxi-Spa secretion machinery; MxiH 142033..142284 Shigella dysenteriae Sd197 3776531 YP_406177.1 CDS mxiI NC_007607.1 142297 142590 D component of the Mxi-Spa secretion machinery; MxiI 142297..142590 Shigella dysenteriae Sd197 3776532 YP_406178.1 CDS mxiJ NC_007607.1 142596 143321 D lipoprotein, component of the Mxi-Spa secretion machinery; MxiJ 142596..143321 Shigella dysenteriae Sd197 3776533 YP_406179.1 CDS mxiK NC_007607.1 143327 143845 D putative component of the Mxi-Spa secretion machinery; MxiK 143327..143845 Shigella dysenteriae Sd197 3776534 YP_406180.1 CDS mxiN NC_007607.1 143787 144482 D putative component of the Mxi-Spa secretion machinery; MxiN 143787..144482 Shigella dysenteriae Sd197 3776535 YP_406181.1 CDS mxiL NC_007607.1 144475 144882 D secreted by and putative component of the Mxi-Spa secretion machinery; MxiL 144475..144882 Shigella dysenteriae Sd197 3776536 YP_406182.1 CDS mxiM NC_007607.1 144866 145294 D lipoprotein, component of the Mxi-Spa secretion machinery; MxiM 144866..145294 Shigella dysenteriae Sd197 3776537 YP_406183.1 CDS mxiE NC_007607.1 145424 146056 D similar to transcriptional activators of the AraC family; MxiE 145424..146056 Shigella dysenteriae Sd197 3776538 YP_406184.1 CDS mxiD NC_007607.1 146043 147743 D outermembrane protein of the secretin family, component of the Mxi-Spa secretion machinery; MxiD 146043..147743 Shigella dysenteriae Sd197 3776539 YP_406185.1 CDS mxiC NC_007607.1 147822 148829 D secreted by and putative component of the Mxi-Spa secretion machinery, similar to YopN (secreted by the type III secretion machinery of Yersinia enterocoltica); MxiC 147822..148829 Shigella dysenteriae Sd197 3776540 YP_406186.1 CDS mxiA NC_007607.1 148836 150902 D innermembrane protein, component of the Mxi-Spa secretion machinery; MxiA 148836..150902 Shigella dysenteriae Sd197 3776541 YP_406187.1 CDS spa15 NC_007607.1 150915 151316 D putative component of the Mxi-Spa secretion machinery; Spa15 150915..151316 Shigella dysenteriae Sd197 3776542 YP_406188.1 CDS spa47 NC_007607.1 151320 152612 D component of the Mxi-Spa secretion machinery, putative ATPase; Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase; ATP synthase SpaL 151320..152612 Shigella dysenteriae Sd197 3776543 YP_406189.1 CDS spa13 NC_007607.1 152756 153043 D component of the Mxi-Spa secretion machinery; Spa13 152756..153043 Shigella dysenteriae Sd197 3776505 YP_406190.1 CDS spa32 NC_007607.1 153030 153908 D secreted by and component of the Mxi-Spa machinery; Spa32 153030..153908 Shigella dysenteriae Sd197 3776506 YP_406191.1 CDS spa33 NC_007607.1 153902 154783 D component of the Mxi-Spa secretion machinery; Spa33 153902..154783 Shigella dysenteriae Sd197 3776507 YP_406192.1 CDS spaP NC_007607.1 154788 155438 D component of the Mxi-Spa secretion machinery; part of a type III secretory system probably involved in invasion into eukaryotic cells; surface presentation of antigens protein SpaP 154788..155438 Shigella dysenteriae Sd197 3776508 YP_001449235.1 CDS spa9 NC_007607.1 155453 155713 D Spa9 155453..155713 Shigella dysenteriae Sd197 5563324 YP_406193.1 CDS spa29 NC_007607.1 155713 156483 D component of the Mxi-Spa secretion machinery; Spa29 155713..156483 Shigella dysenteriae Sd197 3776509 YP_406194.1 CDS spa40 NC_007607.1 156490 157518 D component of the Mxi-Spa secretion machinery; Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins; surface presentation of antigens protein SpaS 156490..157518 Shigella dysenteriae Sd197 3776510 YP_406195.1 CDS spa-orf10 NC_007607.1 157540 157773 D hypothetical protein 157540..157773 Shigella dysenteriae Sd197 3776511 YP_406196.1 CDS SDY_P195 NC_007607.1 158350 158970 R IS600 ORF2 complement(158350..158970) Shigella dysenteriae Sd197 3776512 YP_406197.1 CDS SDY_P196 NC_007607.1 159179 159607 R IS3 ORF2 complement(159179..159607) Shigella dysenteriae Sd197 3776513 YP_406198.1 CDS SDY_P197 NC_007607.1 159579 159797 R IS3 ORF1 complement(159579..159797) Shigella dysenteriae Sd197 3776514 YP_406199.1 CDS SDY_P198 NC_007607.1 160815 161591 R hypothetical protein complement(160815..161591) Shigella dysenteriae Sd197 3776515 YP_406200.1 CDS SDY_P199 NC_007607.1 162115 162315 R putative transposase complement(162115..162315) Shigella dysenteriae Sd197 3776516 YP_406201.1 CDS SDY_P200 NC_007607.1 162252 162452 R putative transposase complement(162252..162452) Shigella dysenteriae Sd197 3776517 YP_406202.1 CDS SDY_P201 NC_007607.1 162546 162923 R putative transposase complement(162546..162923) Shigella dysenteriae Sd197 3776518 YP_406203.1 CDS SDY_P202 NC_007607.1 163141 163461 R hypothetical protein complement(163141..163461) Shigella dysenteriae Sd197 3776519 YP_406204.1 CDS SDY_P203 NC_007607.1 163622 164269 D IS629 ORF2 163622..164269 Shigella dysenteriae Sd197 3776520 YP_406205.1 CDS SDY_P204 NC_007607.1 164747 165148 R IS91 orf complement(164747..165148) Shigella dysenteriae Sd197 3776521 YP_406206.1 CDS SDY_P205 NC_007607.1 165211 165468 R putative IS91 ORF2 complement(165211..165468) Shigella dysenteriae Sd197 3776522 YP_406207.1 CDS SDY_P206 NC_007607.1 166459 166659 R putative reverse transcriptase, fragment complement(166459..166659) Shigella dysenteriae Sd197 3776523 YP_406208.1 CDS SDY_P207 NC_007607.1 166574 166816 R IS3 ORF2 complement(166574..166816) Shigella dysenteriae Sd197 3776524 YP_406209.1 CDS SDY_P208 NC_007607.1 166789 167112 R IS629 ORF2 complement(166789..167112) Shigella dysenteriae Sd197 3776488 YP_406210.1 CDS SDY_P210 NC_007607.1 166995 167351 R IS629 ORF2 complement(166995..167351) Shigella dysenteriae Sd197 3776490 YP_406211.1 CDS SDY_P209 NC_007607.1 167342 167593 D hypothetical protein 167342..167593 Shigella dysenteriae Sd197 3776489 YP_406212.1 CDS virA NC_007607.1 167852 169054 R secreted by the Mxi-Spa secretion machinery; VirA complement(167852..169054) Shigella dysenteriae Sd197 3776491 YP_406213.1 CDS SDY_P212 NC_007607.1 169389 169784 R iso-IS1 ORF2 complement(169389..169784) Shigella dysenteriae Sd197 3776492 YP_406214.1 CDS SDY_P213 NC_007607.1 169811 170083 R iso-IS1 ORF1 complement(169811..170083) Shigella dysenteriae Sd197 3776493 YP_406215.1 CDS icsA NC_007607.1 170357 173665 D VirG; outermembrane protein exposed to the bacterial surface by a C-terminal autotransporter domain and involved in the movement of intracellular bacteria by binding to N-WASP; IcsA 170357..173665 Shigella dysenteriae Sd197 3776494 YP_406216.2 CDS SDY_P215 NC_007607.1 173891 174796 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(173891..174796) Shigella dysenteriae Sd197 3776495 YP_406217.1 CDS SDY_P216 NC_007607.1 174754 175119 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(174754..175119) Shigella dysenteriae Sd197 3776496 YP_406218.1 CDS SDY_P217 NC_007607.1 175253 175876 D IS629 ORF2 175253..175876 Shigella dysenteriae Sd197 3776497 YP_406219.1 CDS SDY_P218 NC_007607.1 176003 176233 D hypothetical protein 176003..176233 Shigella dysenteriae Sd197 3776498 YP_406220.1 CDS repB NC_007607.1 176278 176538 D replication protein 176278..176538 Shigella dysenteriae Sd197 3776499 YP_406221.1 CDS repA NC_007607.1 176840 177697 D RepA; replication protein 176840..177697 Shigella dysenteriae Sd197 3776500 YP_406222.1 CDS SDY_P221 NC_007607.1 179127 179837 R hypothetical protein complement(179127..179837) Shigella dysenteriae Sd197 3776501 YP_406223.1 CDS SDY_P222 NC_007607.1 179875 180027 D IS3 ORF2 179875..180027 Shigella dysenteriae Sd197 3776502 YP_406224.1 CDS SDY_P223 NC_007607.1 180309 180446 R hypothetical protein complement(180309..180446) Shigella dysenteriae Sd197 3776503 YP_406225.2 CDS icsP NC_007607.1 181408 182355 D SopA; outermembrane protease of the OmpP family, involved in cleavage of surface exposed IcsA; outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease 181408..182355 Shigella dysenteriae Sd197 3776504 YP_001139944.1 CDS repA NC_009344.1 741 1697 D replication initiation protein; hypothetical protein 741..1697 Shigella dysenteriae Sd197 4991496 YP_001139945.1 CDS insA NC_009344.1 2073 2348 D IS1 ORF1; hypothetical protein 2073..2348 Shigella dysenteriae Sd197 4991497 YP_001139946.1 CDS insB NC_009344.1 2393 2770 D IS1 ORF2; hypothetical protein 2393..2770 Shigella dysenteriae Sd197 4991498 YP_001139947.1 CDS rfpB NC_009344.1 2979 4112 R glycosyltransferase; RfpB complement(2979..4112) Shigella dysenteriae Sd197 4991499 YP_001139948.1 CDS rfpA NC_009344.1 4330 4920 R glycosyltransferase; RfpA complement(4330..4920) Shigella dysenteriae Sd197 4991500 YP_001139949.1 CDS SDY_PA06 NC_009344.1 5327 6097 R hypothetical protein complement(5327..6097) Shigella dysenteriae Sd197 4991501 YP_001139950.1 CDS SDY_PA07 NC_009344.1 7225 7497 D hypothetical protein 7225..7497 Shigella dysenteriae Sd197 4991502 YP_001139951.1 CDS SDY_PA08 NC_009344.1 7478 8686 D IS1294 transposase 7478..8686 Shigella dysenteriae Sd197 4991503 SDY_0221 tRNA SDY_0221 NC_007606.1 226354 226430 D tRNA-Ile 226354..226430 Shigella dysenteriae Sd197 3797851 SDY_0222 tRNA SDY_0222 NC_007606.1 226473 226548 D tRNA-Ala 226473..226548 Shigella dysenteriae Sd197 3797852 SDY_0225 tRNA SDY_0225 NC_007606.1 229889 229965 D tRNA-Asp 229889..229965 Shigella dysenteriae Sd197 3797855 SDY_0235 tRNA SDY_0235 NC_007606.1 238096 238172 D tRNA-Asp 238096..238172 Shigella dysenteriae Sd197 3796963 SDY_0259 tRNA SDY_0259 NC_007606.1 254305 254381 D tRNA-Arg 254305..254381 Shigella dysenteriae Sd197 3799607 SDY_0472 tRNA SDY_0472 NC_007606.1 460403 460478 R tRNA-Thr complement(460403..460478) Shigella dysenteriae Sd197 3796180 SDY_0573 tRNA SDY_0573 NC_007606.1 552537 552610 R tRNA-Gly complement(552537..552610) Shigella dysenteriae Sd197 3799687 SDY_0574 tRNA SDY_0574 NC_007606.1 552614 552689 R tRNA-Thr complement(552614..552689) Shigella dysenteriae Sd197 3799688 SDY_0575 tRNA SDY_0575 NC_007606.1 552692 552768 R tRNA-Arg complement(552692..552768) Shigella dysenteriae Sd197 3799689 SDY_0576 tRNA SDY_0576 NC_007606.1 552770 552846 R tRNA-Met complement(552770..552846) Shigella dysenteriae Sd197 3798980 SDY_0600 tRNA SDY_0600 NC_007606.1 569916 569990 R tRNA-Gln complement(569916..569990) Shigella dysenteriae Sd197 3796106 SDY_0602 tRNA SDY_0602 NC_007606.1 570039 570115 R tRNA-Met complement(570039..570115) Shigella dysenteriae Sd197 3796108 SDY_0603 tRNA SDY_0603 NC_007606.1 570131 570205 R tRNA-Gln complement(570131..570205) Shigella dysenteriae Sd197 3796109 SDY_0605 tRNA SDY_0605 NC_007606.1 570240 570314 R tRNA-Gln complement(570240..570314) Shigella dysenteriae Sd197 3796111 SDY_0606 tRNA SDY_0606 NC_007606.1 570338 570422 R tRNA-Leu complement(570338..570422) Shigella dysenteriae Sd197 3796112 SDY_0607 tRNA SDY_0607 NC_007606.1 570431 570507 R tRNA-Met complement(570431..570507) Shigella dysenteriae Sd197 3798560 SDY_0691 tRNA SDY_0691 NC_007606.1 653182 653257 D tRNA-Lys 653182..653257 Shigella dysenteriae Sd197 3796641 SDY_0692 tRNA SDY_0692 NC_007606.1 653404 653479 D tRNA-Lys 653404..653479 Shigella dysenteriae Sd197 3796642 SDY_0693 tRNA SDY_0693 NC_007606.1 653513 653588 D tRNA-Lys 653513..653588 Shigella dysenteriae Sd197 3796643 SDY_0890 tRNA SDY_0890 NC_007606.1 838023 838099 R tRNA-Pro complement(838023..838099) Shigella dysenteriae Sd197 3796895 SDY_0946 tRNA SDY_0946 NC_007606.1 894284 894371 R tRNA-Ser complement(894284..894371) Shigella dysenteriae Sd197 3798499 SDY_1005 tRNA SDY_1005 NC_007606.1 952153 952240 D tRNA-Ser 952153..952240 Shigella dysenteriae Sd197 3797140 SDY_1071 tRNA SDY_1071 NC_007606.1 1005132 1005221 R tRNA-Ser complement(1005132..1005221) Shigella dysenteriae Sd197 3799927 SDY_1073 tRNA SDY_1073 NC_007606.1 1006213 1006288 D tRNA-Asn 1006213..1006288 Shigella dysenteriae Sd197 3799929 SDY_1107 tRNA SDY_1107 NC_007606.1 1032986 1033061 D tRNA-Gly 1032986..1033061 Shigella dysenteriae Sd197 3795448 SDY_1108 tRNA SDY_1108 NC_007606.1 1033116 1033189 D tRNA-Cys 1033116..1033189 Shigella dysenteriae Sd197 3795449 SDY_1109 tRNA SDY_1109 NC_007606.1 1033202 1033288 D tRNA-Leu 1033202..1033288 Shigella dysenteriae Sd197 3795450 SDY_1283 tRNA SDY_1283 NC_007606.1 1189324 1189408 R tRNA-Tyr complement(1189324..1189408) Shigella dysenteriae Sd197 3796792 SDY_1437 tRNA SDY_1437 NC_007606.1 1324384 1324459 D tRNA-Met 1324384..1324459 Shigella dysenteriae Sd197 3796028 SDY_1438 tRNA SDY_1438 NC_007606.1 1324558 1324634 D tRNA-Arg 1324558..1324634 Shigella dysenteriae Sd197 3796029 SDY_1892 tRNA SDY_1892 NC_007606.1 1727495 1727571 D tRNA-Val 1727495..1727571 Shigella dysenteriae Sd197 3798231 SDY_1893 tRNA SDY_1893 NC_007606.1 1727576 1727652 D tRNA-Val 1727576..1727652 Shigella dysenteriae Sd197 3798232 SDY_1994 tRNA SDY_1994 NC_007606.1 1810224 1810300 D tRNA-Met 1810224..1810300 Shigella dysenteriae Sd197 3797539 SDY_1995 tRNA SDY_1995 NC_007606.1 1810302 1810378 D tRNA-Arg 1810302..1810378 Shigella dysenteriae Sd197 3797540 SDY_1996 tRNA SDY_1996 NC_007606.1 1810381 1810456 D tRNA-Thr 1810381..1810456 Shigella dysenteriae Sd197 3797541 SDY_1997 tRNA SDY_1997 NC_007606.1 1810460 1810534 D tRNA-Gly 1810460..1810534 Shigella dysenteriae Sd197 3797542 SDY_2244 tRNA SDY_2244 NC_007606.1 2045201 2045276 R tRNA-Asn complement(2045201..2045276) Shigella dysenteriae Sd197 3796978 SDY_2247 tRNA SDY_2247 NC_007606.1 2047609 2047684 R tRNA-Asn complement(2047609..2047684) Shigella dysenteriae Sd197 3796981 SDY_2250 tRNA SDY_2250 NC_007606.1 2049416 2049491 D tRNA-Asn 2049416..2049491 Shigella dysenteriae Sd197 3796984 SDY_2378 tRNA SDY_2378 NC_007606.1 2180695 2180782 D tRNA-Ser 2180695..2180782 Shigella dysenteriae Sd197 3798904 SDY_2552 tRNA SDY_2552 NC_007606.1 2348583 2348657 D tRNA-Arg 2348583..2348657 Shigella dysenteriae Sd197 3795637 SDY_2595 tRNA SDY_2595 NC_007606.1 2393975 2394050 R tRNA-Ala complement(2393975..2394050) Shigella dysenteriae Sd197 3798551 SDY_2601 tRNA SDY_2601 NC_007606.1 2398497 2398572 D tRNA-Val 2398497..2398572 Shigella dysenteriae Sd197 3798557 SDY_2602 tRNA SDY_2602 NC_007606.1 2398616 2398691 D tRNA-Val 2398616..2398691 Shigella dysenteriae Sd197 3798558 SDY_2603 tRNA SDY_2603 NC_007606.1 2398696 2398771 D tRNA-Lys 2398696..2398771 Shigella dysenteriae Sd197 3798559 SDY_2833 tRNA SDY_2833 NC_007606.1 2625222 2625297 R tRNA-Glu complement(2625222..2625297) Shigella dysenteriae Sd197 3795424 SDY_2888 tRNA SDY_2888 NC_007606.1 2671698 2671774 R tRNA-Arg complement(2671698..2671774) Shigella dysenteriae Sd197 3799650 SDY_2889 tRNA SDY_2889 NC_007606.1 2671973 2672049 R tRNA-Arg complement(2671973..2672049) Shigella dysenteriae Sd197 3799651 SDY_2890 tRNA SDY_2890 NC_007606.1 2672245 2672321 R tRNA-Arg complement(2672245..2672321) Shigella dysenteriae Sd197 3796617 SDY_2891 tRNA SDY_2891 NC_007606.1 2672325 2672417 R tRNA-Ser complement(2672325..2672417) Shigella dysenteriae Sd197 3796618 SDY_3032 tRNA SDY_3032 NC_007606.1 2804124 2804200 D tRNA-Met 2804124..2804200 Shigella dysenteriae Sd197 3796121 SDY_3033 tRNA SDY_3033 NC_007606.1 2804235 2804311 D tRNA-Met 2804235..2804311 Shigella dysenteriae Sd197 3796122 SDY_3103 tRNA SDY_3103 NC_007606.1 2878460 2878535 R tRNA-Phe complement(2878460..2878535) Shigella dysenteriae Sd197 3799038 SDY_3253 tRNA SDY_3253 NC_007606.1 3015902 3015977 D tRNA-Met 3015902..3015977 Shigella dysenteriae Sd197 3796765 SDY_3350 tRNA SDY_3350 NC_007606.1 3108924 3109000 R tRNA-Met complement(3108924..3109000) Shigella dysenteriae Sd197 3798426 SDY_3355 tRNA SDY_3355 NC_007606.1 3113477 3113563 R tRNA-Leu complement(3113477..3113563) Shigella dysenteriae Sd197 3798770 SDY_3450 tRNA SDY_3450 NC_007606.1 3206019 3206094 R tRNA-Thr complement(3206019..3206094) Shigella dysenteriae Sd197 3798661 SDY_3453 tRNA SDY_3453 NC_007606.1 3209395 3209470 R tRNA-Ala complement(3209395..3209470) Shigella dysenteriae Sd197 3798664 SDY_3454 tRNA SDY_3454 NC_007606.1 3209513 3209589 R tRNA-Ile complement(3209513..3209589) Shigella dysenteriae Sd197 3798665 SDY_3718 tRNA SDY_3718 NC_007606.1 3448082 3448157 R tRNA-Glu complement(3448082..3448157) Shigella dysenteriae Sd197 3797208 SDY_3749 tRNA SDY_3749 NC_007606.1 3482839 3482914 R tRNA-Thr complement(3482839..3482914) Shigella dysenteriae Sd197 3797938 SDY_3750 tRNA SDY_3750 NC_007606.1 3482921 3482995 R tRNA-Gly complement(3482921..3482995) Shigella dysenteriae Sd197 3797939 SDY_3751 tRNA SDY_3751 NC_007606.1 3483112 3483196 R tRNA-Tyr complement(3483112..3483196) Shigella dysenteriae Sd197 3797940 SDY_3752 tRNA SDY_3752 NC_007606.1 3483205 3483280 R tRNA-Thr complement(3483205..3483280) Shigella dysenteriae Sd197 3797941 SDY_3759 tRNA SDY_3759 NC_007606.1 3490044 3490119 R tRNA-Glu complement(3490044..3490119) Shigella dysenteriae Sd197 3797948 SDY_3892 tRNA SDY_3892 NC_007606.1 3623127 3623202 R tRNA-Ala complement(3623127..3623202) Shigella dysenteriae Sd197 3797008 SDY_3893 tRNA SDY_3893 NC_007606.1 3623245 3623321 R tRNA-Ile complement(3623245..3623321) Shigella dysenteriae Sd197 3797009 SDY_3948 tRNA SDY_3948 NC_007606.1 3680433 3680509 R tRNA-Pro complement(3680433..3680509) Shigella dysenteriae Sd197 3797786 SDY_3949 tRNA SDY_3949 NC_007606.1 3680552 3680638 R tRNA-Leu complement(3680552..3680638) Shigella dysenteriae Sd197 3797446 SDY_3950 tRNA SDY_3950 NC_007606.1 3680659 3680734 R tRNA-His complement(3680659..3680734) Shigella dysenteriae Sd197 3797447 SDY_3951 tRNA SDY_3951 NC_007606.1 3680793 3680869 R tRNA-Arg complement(3680793..3680869) Shigella dysenteriae Sd197 3797448 SDY_3986 tRNA SDY_3986 NC_007606.1 3718795 3718870 R tRNA-Trp complement(3718795..3718870) Shigella dysenteriae Sd197 3798010 SDY_3987 tRNA SDY_3987 NC_007606.1 3718879 3718955 R tRNA-Asp complement(3718879..3718955) Shigella dysenteriae Sd197 3798011 SDY_3990 tRNA SDY_3990 NC_007606.1 3722306 3722381 R tRNA-Glu complement(3722306..3722381) Shigella dysenteriae Sd197 3798014 SDY_4289 tRNA SDY_4289 NC_007606.1 4019704 4019788 D tRNA-Leu 4019704..4019788 Shigella dysenteriae Sd197 3796957 SDY_4427 tRNA SDY_4427 NC_007606.1 4142716 4142791 R tRNA-Gly complement(4142716..4142791) Shigella dysenteriae Sd197 3797355 SDY_4428 tRNA SDY_4428 NC_007606.1 4142827 4142902 R tRNA-Gly complement(4142827..4142902) Shigella dysenteriae Sd197 3797356 SDY_4429 tRNA SDY_4429 NC_007606.1 4142939 4143014 R tRNA-Gly complement(4142939..4143014) Shigella dysenteriae Sd197 3797357 SDY_4439 tRNA SDY_4439 NC_007606.1 4153366 4153441 R tRNA-Phe complement(4153366..4153441) Shigella dysenteriae Sd197 3797367 SDY_4471 tRNA SDY_4471 NC_007606.1 4186256 4186326 D tRNA-Leu 4186256..4186326 Shigella dysenteriae Sd197 3797532 SDY_4568 tRNA SDY_4568 NC_007606.1 4284566 4284642 R tRNA-Pro complement(4284566..4284642) Shigella dysenteriae Sd197 3795664 SDY_4579 tRNA SDY_4579 NC_007606.1 4293303 4293397 D tRNA-Sec 4293303..4293397 Shigella dysenteriae Sd197 3795581 SDY_4627 tRNA SDY_4627 NC_007606.1 4333508 4333594 R tRNA-Leu complement(4333508..4333594) Shigella dysenteriae Sd197 3795382 SDY_4628 tRNA SDY_4628 NC_007606.1 4333629 4333716 R tRNA-Leu complement(4333629..4333716) Shigella dysenteriae Sd197 3795383 SDY_4629 tRNA SDY_4629 NC_007606.1 4333745 4333831 R tRNA-Leu complement(4333745..4333831) Shigella dysenteriae Sd197 3795384 SDY_0220 rRNA rrsH NC_007606.1 224744 226285 D 16S ribosomal RNA 224744..226285 Shigella dysenteriae Sd197 3797850 SDY_0223 rRNA rrlH NC_007606.1 226723 229624 D 23S ribosomal RNA 226723..229624 Shigella dysenteriae Sd197 3797853 SDY_0224 rRNA rrfH NC_007606.1 229718 229836 D 5S ribosomal RNA 229718..229836 Shigella dysenteriae Sd197 3797854 SDY_2831 rRNA rrfG NC_007606.1 2621924 2622042 R 5S ribosomal RNA complement(2621924..2622042) Shigella dysenteriae Sd197 3795422 SDY_2832 rRNA rrlG NC_007606.1 2622136 2625037 R 23S ribosomal RNA complement(2622136..2625037) Shigella dysenteriae Sd197 3795423 SDY_2834 rRNA rrsG NC_007606.1 2625384 2626925 R 16S ribosomal RNA complement(2625384..2626925) Shigella dysenteriae Sd197 3796208 SDY_3449 rRNA rrfF NC_007606.1 3205862 3205978 R 5S ribosomal RNA complement(3205862..3205978) Shigella dysenteriae Sd197 3798660 SDY_3451 rRNA rrfD NC_007606.1 3206107 3206225 R 5S ribosomal RNA complement(3206107..3206225) Shigella dysenteriae Sd197 3798662 SDY_3452 rRNA rrlD NC_007606.1 3206319 3209220 R 23S ribosomal RNA complement(3206319..3209220) Shigella dysenteriae Sd197 3798663 SDY_3455 rRNA rrsD NC_007606.1 3209658 3211199 R 16S ribosomal RNA complement(3209658..3211199) Shigella dysenteriae Sd197 3798666 SDY_3716 rRNA rrfC NC_007606.1 3444784 3444902 R 5S ribosomal RNA complement(3444784..3444902) Shigella dysenteriae Sd197 3797206 SDY_3717 rRNA rrlC NC_007606.1 3444996 3447897 R 23S ribosomal RNA complement(3444996..3447897) Shigella dysenteriae Sd197 3797207 SDY_3719 rRNA rrsC NC_007606.1 3448244 3449785 R 16S ribosomal RNA complement(3448244..3449785) Shigella dysenteriae Sd197 3797209 SDY_3757 rRNA rrfA NC_007606.1 3486746 3486864 R 5S ribosomal RNA complement(3486746..3486864) Shigella dysenteriae Sd197 3797946 SDY_3758 rRNA rrlA NC_007606.1 3486958 3489859 R 23S ribosomal RNA complement(3486958..3489859) Shigella dysenteriae Sd197 3797947 SDY_3760 rRNA rrsA NC_007606.1 3490206 3491747 R 16S ribosomal RNA complement(3490206..3491747) Shigella dysenteriae Sd197 3798618 SDY_3890 rRNA rrfB NC_007606.1 3619839 3619957 R 5S ribosomal RNA complement(3619839..3619957) Shigella dysenteriae Sd197 3797006 SDY_3891 rRNA rrlB NC_007606.1 3620051 3622952 R 23S ribosomal RNA complement(3620051..3622952) Shigella dysenteriae Sd197 3797007 SDY_3894 rRNA rrsB NC_007606.1 3623390 3624931 R 16S ribosomal RNA complement(3623390..3624931) Shigella dysenteriae Sd197 3797010 SDY_3988 rRNA rrfE NC_007606.1 3719008 3719126 R 5S ribosomal RNA complement(3719008..3719126) Shigella dysenteriae Sd197 3798012 SDY_3989 rRNA rrlE NC_007606.1 3719220 3722121 R 23S ribosomal RNA complement(3719220..3722121) Shigella dysenteriae Sd197 3798013 SDY_3991 rRNA rrsE NC_007606.1 3722468 3724009 R 16S ribosomal RNA complement(3722468..3724009) Shigella dysenteriae Sd197 3798015