-- dump date   	20140620_064533
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
425104000001	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
425104000002	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
425104000003	trmE is a tRNA modification GTPase; Region: trmE; cd04164
425104000004	G1 box; other site
425104000005	GTP/Mg2+ binding site [chemical binding]; other site
425104000006	Switch I region; other site
425104000007	G2 box; other site
425104000008	Switch II region; other site
425104000009	G3 box; other site
425104000010	G4 box; other site
425104000011	G5 box; other site
425104000012	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
425104000013	membrane protein insertase; Provisional; Region: PRK01318
425104000014	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
425104000015	Haemolytic domain; Region: Haemolytic; pfam01809
425104000016	ribonuclease P; Reviewed; Region: rnpA; PRK01732
425104000017	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
425104000018	DnaA N-terminal domain; Region: DnaA_N; pfam11638
425104000019	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
425104000020	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104000021	Walker A motif; other site
425104000022	ATP binding site [chemical binding]; other site
425104000023	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
425104000024	Walker B motif; other site
425104000025	arginine finger; other site
425104000026	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
425104000027	DnaA box-binding interface [nucleotide binding]; other site
425104000028	DNA polymerase III subunit beta; Validated; Region: PRK05643
425104000029	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
425104000030	putative DNA binding surface [nucleotide binding]; other site
425104000031	dimer interface [polypeptide binding]; other site
425104000032	beta-clamp/clamp loader binding surface; other site
425104000033	beta-clamp/translesion DNA polymerase binding surface; other site
425104000034	recombination protein F; Reviewed; Region: recF; PRK00064
425104000035	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104000036	Walker A/P-loop; other site
425104000037	ATP binding site [chemical binding]; other site
425104000038	Q-loop/lid; other site
425104000039	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104000040	ABC transporter signature motif; other site
425104000041	Walker B; other site
425104000042	D-loop; other site
425104000043	H-loop/switch region; other site
425104000044	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
425104000045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104000046	Mg2+ binding site [ion binding]; other site
425104000047	G-X-G motif; other site
425104000048	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
425104000049	anchoring element; other site
425104000050	dimer interface [polypeptide binding]; other site
425104000051	ATP binding site [chemical binding]; other site
425104000052	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
425104000053	active site
425104000054	putative metal-binding site [ion binding]; other site
425104000055	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
425104000056	uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801
425104000057	putative active site [active]
425104000058	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
425104000059	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
425104000060	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
425104000061	HDOD domain; Region: HDOD; pfam08668
425104000062	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104000063	Zn2+ binding site [ion binding]; other site
425104000064	Mg2+ binding site [ion binding]; other site
425104000065	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
425104000066	DALR anticodon binding domain; Region: DALR_1; pfam05746
425104000067	anticodon binding site; other site
425104000068	tRNA binding surface [nucleotide binding]; other site
425104000069	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
425104000070	dimer interface [polypeptide binding]; other site
425104000071	motif 1; other site
425104000072	active site
425104000073	motif 2; other site
425104000074	motif 3; other site
425104000075	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
425104000076	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
425104000077	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104000078	putative substrate translocation pore; other site
425104000079	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
425104000080	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
425104000081	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
425104000082	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
425104000083	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
425104000084	active site
425104000085	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
425104000086	MOSC domain; Region: MOSC; pfam03473
425104000087	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
425104000088	CPxP  motif; other site
425104000089	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
425104000090	putative deacylase active site [active]
425104000091	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
425104000092	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
425104000093	dimer interface [polypeptide binding]; other site
425104000094	active site
425104000095	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
425104000096	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
425104000097	substrate binding site [chemical binding]; other site
425104000098	oxyanion hole (OAH) forming residues; other site
425104000099	trimer interface [polypeptide binding]; other site
425104000100	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
425104000101	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
425104000102	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
425104000103	proline dipeptidase; Provisional; Region: PRK13607
425104000104	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
425104000105	active site
425104000106	hypothetical protein; Provisional; Region: PRK11568
425104000107	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
425104000108	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
425104000109	Cation transport protein; Region: TrkH; cl17365
425104000110	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
425104000111	Flavodoxin domain; Region: Flavodoxin_5; cl17428
425104000112	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
425104000113	dimerization interface [polypeptide binding]; other site
425104000114	putative DNA binding site [nucleotide binding]; other site
425104000115	putative Zn2+ binding site [ion binding]; other site
425104000116	Flavodoxin domain; Region: Flavodoxin_5; cl17428
425104000117	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
425104000118	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
425104000119	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
425104000120	TrkA-N domain; Region: TrkA_N; pfam02254
425104000121	TrkA-C domain; Region: TrkA_C; pfam02080
425104000122	TrkA-N domain; Region: TrkA_N; pfam02254
425104000123	TrkA-C domain; Region: TrkA_C; pfam02080
425104000124	16S rRNA methyltransferase B; Provisional; Region: PRK10901
425104000125	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
425104000126	putative RNA binding site [nucleotide binding]; other site
425104000127	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104000128	S-adenosylmethionine binding site [chemical binding]; other site
425104000129	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
425104000130	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
425104000131	putative active site [active]
425104000132	substrate binding site [chemical binding]; other site
425104000133	putative cosubstrate binding site; other site
425104000134	catalytic site [active]
425104000135	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
425104000136	substrate binding site [chemical binding]; other site
425104000137	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
425104000138	active site
425104000139	catalytic residues [active]
425104000140	metal binding site [ion binding]; metal-binding site
425104000141	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
425104000142	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
425104000143	DNA protecting protein DprA; Region: dprA; TIGR00732
425104000144	Protein of unknown function (DUF494); Region: DUF494; pfam04361
425104000145	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
425104000146	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
425104000147	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
425104000148	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
425104000149	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
425104000150	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
425104000151	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
425104000152	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
425104000153	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
425104000154	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
425104000155	shikimate binding site; other site
425104000156	NAD(P) binding site [chemical binding]; other site
425104000157	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
425104000158	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
425104000159	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
425104000160	trimer interface [polypeptide binding]; other site
425104000161	putative metal binding site [ion binding]; other site
425104000162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104000163	PAS fold; Region: PAS_3; pfam08447
425104000164	putative active site [active]
425104000165	heme pocket [chemical binding]; other site
425104000166	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104000167	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104000168	metal binding site [ion binding]; metal-binding site
425104000169	active site
425104000170	I-site; other site
425104000171	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104000172	flagellar motor protein MotB; Validated; Region: motB; PRK09041
425104000173	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
425104000174	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
425104000175	ligand binding site [chemical binding]; other site
425104000176	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
425104000177	flagellar motor stator protein MotA; Region: MotA1; TIGR03818
425104000178	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
425104000179	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
425104000180	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
425104000181	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
425104000182	DNA binding residues [nucleotide binding]
425104000183	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
425104000184	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
425104000185	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
425104000186	Flagellar protein FliS; Region: FliS; cl00654
425104000187	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
425104000188	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
425104000189	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
425104000190	flagellin; Provisional; Region: PRK12802
425104000191	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
425104000192	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
425104000193	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
425104000194	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
425104000195	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191
425104000196	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
425104000197	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
425104000198	peptidoglycan hydrolase; Reviewed; Region: flgJ; PRK12708
425104000199	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
425104000200	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
425104000201	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407
425104000202	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
425104000203	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
425104000204	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
425104000205	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
425104000206	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
425104000207	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
425104000208	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
425104000209	flagellar hook protein FlgE; Validated; Region: flgE; PRK06803
425104000210	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
425104000211	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
425104000212	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK12633
425104000213	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
425104000214	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
425104000215	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802
425104000216	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
425104000217	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
425104000218	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685
425104000219	SAF-like; Region: SAF_2; pfam13144
425104000220	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
425104000221	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
425104000222	FlgN protein; Region: FlgN; pfam05130
425104000223	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
425104000224	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
425104000225	Walker A motif/ATP binding site; other site
425104000226	Walker B motif; other site
425104000227	flagellar assembly protein H; Provisional; Region: fliH; PRK13386
425104000228	Flagellar assembly protein FliH; Region: FliH; pfam02108
425104000229	flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194
425104000230	FliG C-terminal domain; Region: FliG_C; pfam01706
425104000231	flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193
425104000232	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
425104000233	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
425104000234	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
425104000235	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
425104000236	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104000237	Walker A motif; other site
425104000238	ATP binding site [chemical binding]; other site
425104000239	Walker B motif; other site
425104000240	arginine finger; other site
425104000241	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104000242	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
425104000243	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
425104000244	ligand binding site [chemical binding]; other site
425104000245	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
425104000246	flagellar motor switch protein FliN; Region: fliN; TIGR02480
425104000247	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
425104000248	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
425104000249	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
425104000250	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
425104000251	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
425104000252	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
425104000253	FHIPEP family; Region: FHIPEP; pfam00771
425104000254	lysophospholipase L2; Provisional; Region: PRK10749
425104000255	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
425104000256	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
425104000257	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
425104000258	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104000259	FeS/SAM binding site; other site
425104000260	HemN C-terminal domain; Region: HemN_C; pfam06969
425104000261	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
425104000262	Der GTPase activator; Provisional; Region: PRK05244
425104000263	Methyltransferase domain; Region: Methyltransf_23; pfam13489
425104000264	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
425104000265	Cytochrome c553 [Energy production and conversion]; Region: COG2863
425104000266	Cytochrome c; Region: Cytochrom_C; cl11414
425104000267	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
425104000268	G1 box; other site
425104000269	GTP/Mg2+ binding site [chemical binding]; other site
425104000270	Switch I region; other site
425104000271	G2 box; other site
425104000272	G3 box; other site
425104000273	Switch II region; other site
425104000274	G4 box; other site
425104000275	G5 box; other site
425104000276	DNA polymerase I; Provisional; Region: PRK05755
425104000277	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
425104000278	active site
425104000279	metal binding site 1 [ion binding]; metal-binding site
425104000280	putative 5' ssDNA interaction site; other site
425104000281	metal binding site 3; metal-binding site
425104000282	metal binding site 2 [ion binding]; metal-binding site
425104000283	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
425104000284	putative DNA binding site [nucleotide binding]; other site
425104000285	putative metal binding site [ion binding]; other site
425104000286	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
425104000287	active site
425104000288	catalytic site [active]
425104000289	substrate binding site [chemical binding]; other site
425104000290	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
425104000291	active site
425104000292	DNA binding site [nucleotide binding]
425104000293	catalytic site [active]
425104000294	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
425104000295	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
425104000296	conserved cys residue [active]
425104000297	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
425104000298	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
425104000299	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
425104000300	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
425104000301	active site residue [active]
425104000302	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
425104000303	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
425104000304	NAD(P) binding site [chemical binding]; other site
425104000305	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
425104000306	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
425104000307	substrate-cofactor binding pocket; other site
425104000308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104000309	catalytic residue [active]
425104000310	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104000311	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104000312	Bacterial transcriptional repressor; Region: TetR; pfam13972
425104000313	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104000314	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104000315	Bacterial transcriptional repressor; Region: TetR; pfam13972
425104000316	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
425104000317	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
425104000318	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
425104000319	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
425104000320	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
425104000321	active site
425104000322	ATP binding site [chemical binding]; other site
425104000323	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
425104000324	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
425104000325	NADP binding site [chemical binding]; other site
425104000326	active site
425104000327	putative substrate binding site [chemical binding]; other site
425104000328	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
425104000329	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
425104000330	NAD binding site [chemical binding]; other site
425104000331	substrate binding site [chemical binding]; other site
425104000332	homodimer interface [polypeptide binding]; other site
425104000333	active site
425104000334	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
425104000335	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
425104000336	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
425104000337	putative active site [active]
425104000338	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
425104000339	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
425104000340	Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174
425104000341	active site
425104000342	metal binding site [ion binding]; metal-binding site
425104000343	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964
425104000344	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
425104000345	active site
425104000346	nucleotide binding site [chemical binding]; other site
425104000347	HIGH motif; other site
425104000348	KMSKS motif; other site
425104000349	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
425104000350	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
425104000351	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
425104000352	active site
425104000353	(T/H)XGH motif; other site
425104000354	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
425104000355	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
425104000356	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
425104000357	DNA binding site [nucleotide binding]
425104000358	catalytic residue [active]
425104000359	H2TH interface [polypeptide binding]; other site
425104000360	putative catalytic residues [active]
425104000361	turnover-facilitating residue; other site
425104000362	intercalation triad [nucleotide binding]; other site
425104000363	8OG recognition residue [nucleotide binding]; other site
425104000364	putative reading head residues; other site
425104000365	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
425104000366	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
425104000367	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
425104000368	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104000369	FeS/SAM binding site; other site
425104000370	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
425104000371	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491
425104000372	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
425104000373	Walker A motif; other site
425104000374	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
425104000375	dimer interface [polypeptide binding]; other site
425104000376	putative functional site; other site
425104000377	putative MPT binding site; other site
425104000378	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
425104000379	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
425104000380	GTP binding site; other site
425104000381	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
425104000382	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104000383	Walker A/P-loop; other site
425104000384	ATP binding site [chemical binding]; other site
425104000385	Q-loop/lid; other site
425104000386	ABC transporter signature motif; other site
425104000387	Walker B; other site
425104000388	D-loop; other site
425104000389	H-loop/switch region; other site
425104000390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104000391	dimer interface [polypeptide binding]; other site
425104000392	conserved gate region; other site
425104000393	putative PBP binding loops; other site
425104000394	ABC-ATPase subunit interface; other site
425104000395	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
425104000396	PBP superfamily domain; Region: PBP_like_2; pfam12849
425104000397	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
425104000398	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104000399	active site
425104000400	phosphorylation site [posttranslational modification]
425104000401	intermolecular recognition site; other site
425104000402	dimerization interface [polypeptide binding]; other site
425104000403	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104000404	Walker A motif; other site
425104000405	ATP binding site [chemical binding]; other site
425104000406	Walker B motif; other site
425104000407	arginine finger; other site
425104000408	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104000409	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
425104000410	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104000411	dimer interface [polypeptide binding]; other site
425104000412	phosphorylation site [posttranslational modification]
425104000413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104000414	ATP binding site [chemical binding]; other site
425104000415	G-X-G motif; other site
425104000416	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104000417	Coenzyme A binding pocket [chemical binding]; other site
425104000418	hypothetical protein; Provisional; Region: PRK11212
425104000419	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104000420	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104000421	substrate binding pocket [chemical binding]; other site
425104000422	membrane-bound complex binding site; other site
425104000423	hinge residues; other site
425104000424	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
425104000425	chorismate binding enzyme; Region: Chorismate_bind; cl10555
425104000426	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
425104000427	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104000428	N-terminal plug; other site
425104000429	ligand-binding site [chemical binding]; other site
425104000430	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
425104000431	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
425104000432	Walker A/P-loop; other site
425104000433	ATP binding site [chemical binding]; other site
425104000434	Q-loop/lid; other site
425104000435	ABC transporter signature motif; other site
425104000436	Walker B; other site
425104000437	D-loop; other site
425104000438	H-loop/switch region; other site
425104000439	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
425104000440	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104000441	Walker A/P-loop; other site
425104000442	ATP binding site [chemical binding]; other site
425104000443	Q-loop/lid; other site
425104000444	ABC transporter signature motif; other site
425104000445	Walker B; other site
425104000446	D-loop; other site
425104000447	H-loop/switch region; other site
425104000448	Cobalt transport protein; Region: CbiQ; cl00463
425104000449	methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280
425104000450	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
425104000451	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
425104000452	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104000453	Zn2+ binding site [ion binding]; other site
425104000454	Mg2+ binding site [ion binding]; other site
425104000455	Paraquat-inducible protein A; Region: PqiA; pfam04403
425104000456	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104000457	dimerization interface [polypeptide binding]; other site
425104000458	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104000459	dimer interface [polypeptide binding]; other site
425104000460	phosphorylation site [posttranslational modification]
425104000461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104000462	ATP binding site [chemical binding]; other site
425104000463	Mg2+ binding site [ion binding]; other site
425104000464	G-X-G motif; other site
425104000465	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
425104000466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104000467	active site
425104000468	phosphorylation site [posttranslational modification]
425104000469	intermolecular recognition site; other site
425104000470	dimerization interface [polypeptide binding]; other site
425104000471	Hpt domain; Region: Hpt; pfam01627
425104000472	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
425104000473	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
425104000474	conserved cys residue [active]
425104000475	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
425104000476	glutathione reductase; Validated; Region: PRK06116
425104000477	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
425104000478	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
425104000479	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
425104000480	oligopeptidase A; Provisional; Region: PRK10911
425104000481	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
425104000482	active site
425104000483	Zn binding site [ion binding]; other site
425104000484	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
425104000485	active site
425104000486	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
425104000487	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
425104000488	GSH binding site (G-site) [chemical binding]; other site
425104000489	C-terminal domain interface [polypeptide binding]; other site
425104000490	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
425104000491	N-terminal domain interface [polypeptide binding]; other site
425104000492	dimer interface [polypeptide binding]; other site
425104000493	substrate binding pocket (H-site) [chemical binding]; other site
425104000494	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104000495	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104000496	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104000497	putative effector binding pocket; other site
425104000498	dimerization interface [polypeptide binding]; other site
425104000499	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
425104000500	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
425104000501	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
425104000502	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104000503	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104000504	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
425104000505	Protein export membrane protein; Region: SecD_SecF; cl14618
425104000506	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
425104000507	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
425104000508	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
425104000509	putative N-terminal domain interface [polypeptide binding]; other site
425104000510	putative dimer interface [polypeptide binding]; other site
425104000511	putative substrate binding pocket (H-site) [chemical binding]; other site
425104000512	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
425104000513	Mechanosensitive ion channel; Region: MS_channel; pfam00924
425104000514	AbgT putative transporter family; Region: ABG_transport; pfam03806
425104000515	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
425104000516	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
425104000517	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
425104000518	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
425104000519	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
425104000520	N-acetyl-D-glucosamine binding site [chemical binding]; other site
425104000521	catalytic residue [active]
425104000522	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
425104000523	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
425104000524	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104000525	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104000526	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104000527	dimerization interface [polypeptide binding]; other site
425104000528	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
425104000529	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
425104000530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104000531	S-adenosylmethionine binding site [chemical binding]; other site
425104000532	Protein of unknown function (DUF2860); Region: DUF2860; pfam11059
425104000533	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
425104000534	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104000535	dimerization interface [polypeptide binding]; other site
425104000536	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104000537	dimer interface [polypeptide binding]; other site
425104000538	phosphorylation site [posttranslational modification]
425104000539	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104000540	ATP binding site [chemical binding]; other site
425104000541	Mg2+ binding site [ion binding]; other site
425104000542	G-X-G motif; other site
425104000543	osmolarity response regulator; Provisional; Region: ompR; PRK09468
425104000544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104000545	active site
425104000546	phosphorylation site [posttranslational modification]
425104000547	intermolecular recognition site; other site
425104000548	dimerization interface [polypeptide binding]; other site
425104000549	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104000550	DNA binding site [nucleotide binding]
425104000551	Escherichia coli YaeB and related proteins; Region: UPF0066; cl00749
425104000552	cofactor binding site; other site
425104000553	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
425104000554	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
425104000555	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
425104000556	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
425104000557	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
425104000558	PYR/PP interface [polypeptide binding]; other site
425104000559	dimer interface [polypeptide binding]; other site
425104000560	TPP binding site [chemical binding]; other site
425104000561	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
425104000562	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
425104000563	TPP-binding site [chemical binding]; other site
425104000564	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
425104000565	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
425104000566	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
425104000567	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
425104000568	RNA binding site [nucleotide binding]; other site
425104000569	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
425104000570	Sulfatase; Region: Sulfatase; pfam00884
425104000571	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
425104000572	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
425104000573	DNA utilization protein GntX; Provisional; Region: PRK11595
425104000574	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
425104000575	active site
425104000576	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
425104000577	putative active site [active]
425104000578	Zn binding site [ion binding]; other site
425104000579	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
425104000580	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
425104000581	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
425104000582	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
425104000583	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
425104000584	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973
425104000585	putative active site [active]
425104000586	putative metal binding site [ion binding]; other site
425104000587	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
425104000588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104000589	active site
425104000590	phosphorylation site [posttranslational modification]
425104000591	intermolecular recognition site; other site
425104000592	dimerization interface [polypeptide binding]; other site
425104000593	CheB methylesterase; Region: CheB_methylest; pfam01339
425104000594	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
425104000595	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
425104000596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104000597	PAS domain; Region: PAS_9; pfam13426
425104000598	PAS domain; Region: PAS_9; pfam13426
425104000599	PAS domain; Region: PAS_9; pfam13426
425104000600	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104000601	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104000602	dimer interface [polypeptide binding]; other site
425104000603	putative CheW interface [polypeptide binding]; other site
425104000604	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
425104000605	putative CheA interaction surface; other site
425104000606	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
425104000607	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
425104000608	putative binding surface; other site
425104000609	active site
425104000610	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
425104000611	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104000612	ATP binding site [chemical binding]; other site
425104000613	G-X-G motif; other site
425104000614	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
425104000615	Response regulator receiver domain; Region: Response_reg; pfam00072
425104000616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104000617	active site
425104000618	phosphorylation site [posttranslational modification]
425104000619	intermolecular recognition site; other site
425104000620	dimerization interface [polypeptide binding]; other site
425104000621	STAS domain; Region: STAS_2; pfam13466
425104000622	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
425104000623	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
425104000624	Cu(I) binding site [ion binding]; other site
425104000625	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
425104000626	UbiA prenyltransferase family; Region: UbiA; pfam01040
425104000627	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
425104000628	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
425104000629	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
425104000630	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
425104000631	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
425104000632	Subunit III/VIIa interface [polypeptide binding]; other site
425104000633	Phospholipid binding site [chemical binding]; other site
425104000634	Subunit I/III interface [polypeptide binding]; other site
425104000635	Subunit III/VIb interface [polypeptide binding]; other site
425104000636	Subunit III/VIa interface; other site
425104000637	Subunit III/Vb interface [polypeptide binding]; other site
425104000638	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
425104000639	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
425104000640	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
425104000641	Subunit I/III interface [polypeptide binding]; other site
425104000642	D-pathway; other site
425104000643	Subunit I/VIIc interface [polypeptide binding]; other site
425104000644	Subunit I/IV interface [polypeptide binding]; other site
425104000645	Subunit I/II interface [polypeptide binding]; other site
425104000646	Low-spin heme (heme a) binding site [chemical binding]; other site
425104000647	Subunit I/VIIa interface [polypeptide binding]; other site
425104000648	Subunit I/VIa interface [polypeptide binding]; other site
425104000649	Dimer interface; other site
425104000650	Putative water exit pathway; other site
425104000651	Binuclear center (heme a3/CuB) [ion binding]; other site
425104000652	K-pathway; other site
425104000653	Subunit I/Vb interface [polypeptide binding]; other site
425104000654	Putative proton exit pathway; other site
425104000655	Subunit I/VIb interface; other site
425104000656	Subunit I/VIc interface [polypeptide binding]; other site
425104000657	Electron transfer pathway; other site
425104000658	Subunit I/VIIIb interface [polypeptide binding]; other site
425104000659	Subunit I/VIIb interface [polypeptide binding]; other site
425104000660	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
425104000661	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
425104000662	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
425104000663	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
425104000664	Cytochrome c; Region: Cytochrom_C; pfam00034
425104000665	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
425104000666	Cytochrome c; Region: Cytochrom_C; pfam00034
425104000667	Cell division inhibitor SulA; Region: SulA; cl01880
425104000668	LexA repressor; Validated; Region: PRK00215
425104000669	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
425104000670	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
425104000671	Catalytic site [active]
425104000672	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
425104000673	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
425104000674	putative acyl-acceptor binding pocket; other site
425104000675	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
425104000676	aromatic amino acid transport protein; Region: araaP; TIGR00837
425104000677	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
425104000678	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
425104000679	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104000680	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
425104000681	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104000682	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104000683	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104000684	metal binding site [ion binding]; metal-binding site
425104000685	active site
425104000686	I-site; other site
425104000687	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
425104000688	heme-binding site [chemical binding]; other site
425104000689	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
425104000690	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104000691	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
425104000692	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104000693	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104000694	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104000695	dimerization interface [polypeptide binding]; other site
425104000696	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104000697	dimer interface [polypeptide binding]; other site
425104000698	putative CheW interface [polypeptide binding]; other site
425104000699	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
425104000700	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104000701	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104000702	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
425104000703	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
425104000704	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
425104000705	Protein of unknown function (DUF1145); Region: DUF1145; cl11481
425104000706	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
425104000707	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104000708	S-adenosylmethionine binding site [chemical binding]; other site
425104000709	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
425104000710	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
425104000711	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
425104000712	P loop; other site
425104000713	GTP binding site [chemical binding]; other site
425104000714	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
425104000715	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104000716	Walker A/P-loop; other site
425104000717	ATP binding site [chemical binding]; other site
425104000718	Q-loop/lid; other site
425104000719	ABC transporter signature motif; other site
425104000720	Walker B; other site
425104000721	D-loop; other site
425104000722	H-loop/switch region; other site
425104000723	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
425104000724	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
425104000725	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
425104000726	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
425104000727	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
425104000728	DNA binding residues [nucleotide binding]
425104000729	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
425104000730	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
425104000731	acyl-activating enzyme (AAE) consensus motif; other site
425104000732	putative AMP binding site [chemical binding]; other site
425104000733	putative active site [active]
425104000734	putative CoA binding site [chemical binding]; other site
425104000735	O-succinylbenzoate synthase; Provisional; Region: PRK05105
425104000736	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
425104000737	active site
425104000738	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
425104000739	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
425104000740	nucleophilic elbow; other site
425104000741	catalytic triad; other site
425104000742	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
425104000743	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
425104000744	dimer interface [polypeptide binding]; other site
425104000745	tetramer interface [polypeptide binding]; other site
425104000746	PYR/PP interface [polypeptide binding]; other site
425104000747	TPP binding site [chemical binding]; other site
425104000748	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
425104000749	TPP-binding site; other site
425104000750	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104000751	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104000752	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104000753	Protein of unknown function (DUF3374); Region: DUF3374; pfam11854
425104000754	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
425104000755	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
425104000756	molybdopterin cofactor binding site; other site
425104000757	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
425104000758	molybdopterin cofactor binding site; other site
425104000759	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
425104000760	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
425104000761	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104000762	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104000763	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
425104000764	catalytic residues [active]
425104000765	hinge region; other site
425104000766	alpha helical domain; other site
425104000767	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
425104000768	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
425104000769	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
425104000770	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104000771	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104000772	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104000773	dimerization interface [polypeptide binding]; other site
425104000774	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104000775	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104000776	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104000777	dimerization interface [polypeptide binding]; other site
425104000778	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
425104000779	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
425104000780	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
425104000781	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
425104000782	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
425104000783	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
425104000784	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
425104000785	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104000786	S-adenosylmethionine binding site [chemical binding]; other site
425104000787	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
425104000788	putative metal binding site [ion binding]; other site
425104000789	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
425104000790	multidrug efflux protein; Reviewed; Region: PRK09577
425104000791	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
425104000792	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
425104000793	Sel1-like repeats; Region: SEL1; smart00671
425104000794	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
425104000795	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104000796	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
425104000797	substrate binding pocket [chemical binding]; other site
425104000798	dimerization interface [polypeptide binding]; other site
425104000799	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104000800	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
425104000801	putative substrate translocation pore; other site
425104000802	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
425104000803	DTW domain; Region: DTW; cl01221
425104000804	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104000805	PAS domain; Region: PAS_9; pfam13426
425104000806	putative active site [active]
425104000807	heme pocket [chemical binding]; other site
425104000808	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104000809	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104000810	metal binding site [ion binding]; metal-binding site
425104000811	active site
425104000812	I-site; other site
425104000813	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104000814	Methyltransferase domain; Region: Methyltransf_23; pfam13489
425104000815	Methyltransferase domain; Region: Methyltransf_11; pfam08241
425104000816	Flagellar protein YcgR; Region: YcgR_2; pfam12945
425104000817	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
425104000818	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
425104000819	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
425104000820	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
425104000821	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
425104000822	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
425104000823	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104000824	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104000825	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
425104000826	substrate binding pocket [chemical binding]; other site
425104000827	dimerization interface [polypeptide binding]; other site
425104000828	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
425104000829	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
425104000830	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104000831	FeS/SAM binding site; other site
425104000832	hypothetical protein; Provisional; Region: PRK10977
425104000833	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
425104000834	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
425104000835	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
425104000836	NAD(P) binding site [chemical binding]; other site
425104000837	catalytic residues [active]
425104000838	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
425104000839	GAF domain; Region: GAF; pfam01590
425104000840	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104000841	putative active site [active]
425104000842	heme pocket [chemical binding]; other site
425104000843	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104000844	Walker A motif; other site
425104000845	ATP binding site [chemical binding]; other site
425104000846	Walker B motif; other site
425104000847	arginine finger; other site
425104000848	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104000849	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
425104000850	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
425104000851	NADP binding site [chemical binding]; other site
425104000852	dimer interface [polypeptide binding]; other site
425104000853	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104000854	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104000855	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
425104000856	substrate binding pocket [chemical binding]; other site
425104000857	dimerization interface [polypeptide binding]; other site
425104000858	L-aspartate oxidase; Provisional; Region: PRK06175
425104000859	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
425104000860	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
425104000861	heme-binding residues [chemical binding]; other site
425104000862	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104000863	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104000864	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104000865	dimerization interface [polypeptide binding]; other site
425104000866	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104000867	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104000868	two-component sensor protein; Provisional; Region: cpxA; PRK09470
425104000869	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104000870	dimerization interface [polypeptide binding]; other site
425104000871	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104000872	ATP binding site [chemical binding]; other site
425104000873	Mg2+ binding site [ion binding]; other site
425104000874	G-X-G motif; other site
425104000875	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
425104000876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104000877	active site
425104000878	phosphorylation site [posttranslational modification]
425104000879	intermolecular recognition site; other site
425104000880	dimerization interface [polypeptide binding]; other site
425104000881	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104000882	DNA binding site [nucleotide binding]
425104000883	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
425104000884	dimer interface [polypeptide binding]; other site
425104000885	Cation efflux family; Region: Cation_efflux; cl00316
425104000886	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
425104000887	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
425104000888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104000889	active site
425104000890	phosphorylation site [posttranslational modification]
425104000891	intermolecular recognition site; other site
425104000892	dimerization interface [polypeptide binding]; other site
425104000893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104000894	Walker A motif; other site
425104000895	ATP binding site [chemical binding]; other site
425104000896	Walker B motif; other site
425104000897	arginine finger; other site
425104000898	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104000899	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
425104000900	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
425104000901	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104000902	dimer interface [polypeptide binding]; other site
425104000903	phosphorylation site [posttranslational modification]
425104000904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104000905	ATP binding site [chemical binding]; other site
425104000906	Mg2+ binding site [ion binding]; other site
425104000907	G-X-G motif; other site
425104000908	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
425104000909	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
425104000910	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
425104000911	potential catalytic triad [active]
425104000912	conserved cys residue [active]
425104000913	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
425104000914	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
425104000915	dimer interface [polypeptide binding]; other site
425104000916	active site
425104000917	metal binding site [ion binding]; metal-binding site
425104000918	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104000919	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104000920	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
425104000921	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
425104000922	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
425104000923	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104000924	putative active site [active]
425104000925	heme pocket [chemical binding]; other site
425104000926	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104000927	dimer interface [polypeptide binding]; other site
425104000928	phosphorylation site [posttranslational modification]
425104000929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104000930	ATP binding site [chemical binding]; other site
425104000931	Mg2+ binding site [ion binding]; other site
425104000932	G-X-G motif; other site
425104000933	Response regulator receiver domain; Region: Response_reg; pfam00072
425104000934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104000935	active site
425104000936	phosphorylation site [posttranslational modification]
425104000937	intermolecular recognition site; other site
425104000938	dimerization interface [polypeptide binding]; other site
425104000939	NMT1/THI5 like; Region: NMT1; pfam09084
425104000940	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
425104000941	glutamine synthetase; Provisional; Region: glnA; PRK09469
425104000942	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
425104000943	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
425104000944	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
425104000945	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
425104000946	G1 box; other site
425104000947	putative GEF interaction site [polypeptide binding]; other site
425104000948	GTP/Mg2+ binding site [chemical binding]; other site
425104000949	Switch I region; other site
425104000950	G2 box; other site
425104000951	G3 box; other site
425104000952	Switch II region; other site
425104000953	G4 box; other site
425104000954	G5 box; other site
425104000955	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
425104000956	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
425104000957	4Fe-4S binding domain; Region: Fer4_5; pfam12801
425104000958	4Fe-4S binding domain; Region: Fer4_5; pfam12801
425104000959	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
425104000960	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
425104000961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104000962	Major Facilitator Superfamily; Region: MFS_1; pfam07690
425104000963	putative substrate translocation pore; other site
425104000964	chaperone protein DnaJ; Provisional; Region: PRK14281
425104000965	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
425104000966	Activator of aromatic catabolism; Region: XylR_N; pfam06505
425104000967	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
425104000968	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
425104000969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104000970	Walker B motif; other site
425104000971	arginine finger; other site
425104000972	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104000973	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
425104000974	hypothetical protein; Reviewed; Region: PRK01637
425104000975	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
425104000976	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
425104000977	putative active site [active]
425104000978	dimerization interface [polypeptide binding]; other site
425104000979	putative tRNAtyr binding site [nucleotide binding]; other site
425104000980	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
425104000981	azoreductase; Reviewed; Region: PRK00170
425104000982	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
425104000983	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
425104000984	active site residue [active]
425104000985	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
425104000986	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
425104000987	dimer interface [polypeptide binding]; other site
425104000988	active site
425104000989	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
425104000990	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
425104000991	NAD(P) binding site [chemical binding]; other site
425104000992	homotetramer interface [polypeptide binding]; other site
425104000993	homodimer interface [polypeptide binding]; other site
425104000994	active site
425104000995	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
425104000996	putative active site 1 [active]
425104000997	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
425104000998	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
425104000999	dimer interface [polypeptide binding]; other site
425104001000	active site
425104001001	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
425104001002	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
425104001003	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
425104001004	Predicted exporter [General function prediction only]; Region: COG4258
425104001005	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
425104001006	active site
425104001007	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
425104001008	active sites [active]
425104001009	tetramer interface [polypeptide binding]; other site
425104001010	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
425104001011	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
425104001012	Ligand binding site; other site
425104001013	Putative Catalytic site; other site
425104001014	DXD motif; other site
425104001015	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
425104001016	putative acyl-acceptor binding pocket; other site
425104001017	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
425104001018	active site 1 [active]
425104001019	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
425104001020	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
425104001021	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
425104001022	acyl-activating enzyme (AAE) consensus motif; other site
425104001023	acyl-activating enzyme (AAE) consensus motif; other site
425104001024	AMP binding site [chemical binding]; other site
425104001025	active site
425104001026	CoA binding site [chemical binding]; other site
425104001027	Predicted membrane protein [Function unknown]; Region: COG4648
425104001028	acyl carrier protein; Provisional; Region: PRK05350
425104001029	Phosphopantetheine attachment site; Region: PP-binding; cl09936
425104001030	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
425104001031	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
425104001032	putative acyl-acceptor binding pocket; other site
425104001033	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
425104001034	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
425104001035	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
425104001036	Y-family of DNA polymerases; Region: PolY; cl12025
425104001037	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
425104001038	generic binding surface II; other site
425104001039	ssDNA binding site; other site
425104001040	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104001041	ATP binding site [chemical binding]; other site
425104001042	putative Mg++ binding site [ion binding]; other site
425104001043	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104001044	nucleotide binding region [chemical binding]; other site
425104001045	ATP-binding site [chemical binding]; other site
425104001046	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
425104001047	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
425104001048	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
425104001049	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
425104001050	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
425104001051	acyl-activating enzyme (AAE) consensus motif; other site
425104001052	putative AMP binding site [chemical binding]; other site
425104001053	putative active site [active]
425104001054	putative CoA binding site [chemical binding]; other site
425104001055	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
425104001056	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
425104001057	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
425104001058	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
425104001059	homotrimer interaction site [polypeptide binding]; other site
425104001060	putative active site [active]
425104001061	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
425104001062	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104001063	Zn2+ binding site [ion binding]; other site
425104001064	Mg2+ binding site [ion binding]; other site
425104001065	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
425104001066	synthetase active site [active]
425104001067	NTP binding site [chemical binding]; other site
425104001068	metal binding site [ion binding]; metal-binding site
425104001069	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
425104001070	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
425104001071	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
425104001072	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
425104001073	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
425104001074	catalytic site [active]
425104001075	G-X2-G-X-G-K; other site
425104001076	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
425104001077	active site
425104001078	TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; Region: TAF12; cl17384
425104001079	Phosphotransferase enzyme family; Region: APH; pfam01636
425104001080	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
425104001081	active site
425104001082	substrate binding site [chemical binding]; other site
425104001083	ATP binding site [chemical binding]; other site
425104001084	Protein of unknown function (DUF3360); Region: DUF3360; pfam11840
425104001085	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
425104001086	active sites [active]
425104001087	tetramer interface [polypeptide binding]; other site
425104001088	L-aspartate oxidase; Provisional; Region: PRK06175
425104001089	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
425104001090	L-aspartate oxidase; Provisional; Region: PRK06175
425104001091	GAF domain; Region: GAF_2; pfam13185
425104001092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104001093	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
425104001094	Walker A motif; other site
425104001095	ATP binding site [chemical binding]; other site
425104001096	Walker B motif; other site
425104001097	arginine finger; other site
425104001098	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104001099	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
425104001100	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
425104001101	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
425104001102	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
425104001103	molybdopterin cofactor binding site; other site
425104001104	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
425104001105	putative molybdopterin cofactor binding site; other site
425104001106	Protein of unknown function (DUF3374); Region: DUF3374; pfam11854
425104001107	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104001108	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104001109	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104001110	OPT oligopeptide transporter protein; Region: OPT; pfam03169
425104001111	oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728
425104001112	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104001113	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104001114	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
425104001115	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
425104001116	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
425104001117	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
425104001118	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
425104001119	molybdopterin cofactor binding site; other site
425104001120	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
425104001121	molybdopterin cofactor binding site; other site
425104001122	Protein of unknown function (DUF3374); Region: DUF3374; pfam11854
425104001123	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104001124	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104001125	Winged helix-turn helix; Region: HTH_29; pfam13551
425104001126	Helix-turn-helix domain; Region: HTH_28; pfam13518
425104001127	Homeodomain-like domain; Region: HTH_32; pfam13565
425104001128	Integrase core domain; Region: rve; pfam00665
425104001129	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
425104001130	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
425104001131	transmembrane helices; other site
425104001132	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
425104001133	putative active site [active]
425104001134	putative metal binding residues [ion binding]; other site
425104001135	signature motif; other site
425104001136	putative dimer interface [polypeptide binding]; other site
425104001137	putative phosphate binding site [ion binding]; other site
425104001138	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
425104001139	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
425104001140	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
425104001141	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
425104001142	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
425104001143	DHH family; Region: DHH; pfam01368
425104001144	DHHA2 domain; Region: DHHA2; pfam02833
425104001145	adenylate kinase; Reviewed; Region: adk; PRK00279
425104001146	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
425104001147	AMP-binding site [chemical binding]; other site
425104001148	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
425104001149	ERCC4 domain; Region: ERCC4; smart00891
425104001150	Helix-hairpin-helix motif; Region: HHH; pfam00633
425104001151	HipA N-terminal domain; Region: Couple_hipA; pfam13657
425104001152	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
425104001153	HipA-like N-terminal domain; Region: HipA_N; pfam07805
425104001154	HipA-like C-terminal domain; Region: HipA_C; pfam07804
425104001155	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
425104001156	non-specific DNA binding site [nucleotide binding]; other site
425104001157	salt bridge; other site
425104001158	sequence-specific DNA binding site [nucleotide binding]; other site
425104001159	hypothetical protein; Provisional; Region: PRK11820
425104001160	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
425104001161	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
425104001162	ribonuclease PH; Reviewed; Region: rph; PRK00173
425104001163	Ribonuclease PH; Region: RNase_PH_bact; cd11362
425104001164	hexamer interface [polypeptide binding]; other site
425104001165	active site
425104001166	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
425104001167	active site
425104001168	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
425104001169	GTP cyclohydrolase I; Provisional; Region: PLN03044
425104001170	active site
425104001171	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
425104001172	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104001173	division inhibitor protein; Provisional; Region: slmA; PRK09480
425104001174	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104001175	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
425104001176	trimer interface [polypeptide binding]; other site
425104001177	active site
425104001178	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
425104001179	Flavoprotein; Region: Flavoprotein; pfam02441
425104001180	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
425104001181	hypothetical protein; Reviewed; Region: PRK00024
425104001182	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
425104001183	MPN+ (JAMM) motif; other site
425104001184	Zinc-binding site [ion binding]; other site
425104001185	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
425104001186	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
425104001187	N-acetylglutamate synthase; Validated; Region: PRK05279
425104001188	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
425104001189	putative feedback inhibition sensing region; other site
425104001190	putative nucleotide binding site [chemical binding]; other site
425104001191	putative substrate binding site [chemical binding]; other site
425104001192	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104001193	Coenzyme A binding pocket [chemical binding]; other site
425104001194	Predicted permeases [General function prediction only]; Region: RarD; COG2962
425104001195	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
425104001196	CoenzymeA binding site [chemical binding]; other site
425104001197	subunit interaction site [polypeptide binding]; other site
425104001198	PHB binding site; other site
425104001199	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
425104001200	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104001201	ATP binding site [chemical binding]; other site
425104001202	putative Mg++ binding site [ion binding]; other site
425104001203	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104001204	nucleotide binding region [chemical binding]; other site
425104001205	ATP-binding site [chemical binding]; other site
425104001206	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
425104001207	HRDC domain; Region: HRDC; pfam00570
425104001208	Tetratricopeptide repeat; Region: TPR_12; pfam13424
425104001209	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
425104001210	binding surface
425104001211	TPR motif; other site
425104001212	Tetratricopeptide repeat; Region: TPR_12; pfam13424
425104001213	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104001214	active site
425104001215	I-site; other site
425104001216	2-isopropylmalate synthase; Validated; Region: PRK00915
425104001217	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
425104001218	active site
425104001219	catalytic residues [active]
425104001220	metal binding site [ion binding]; metal-binding site
425104001221	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
425104001222	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
425104001223	tartrate dehydrogenase; Provisional; Region: PRK08194
425104001224	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
425104001225	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
425104001226	substrate binding site [chemical binding]; other site
425104001227	ligand binding site [chemical binding]; other site
425104001228	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
425104001229	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
425104001230	substrate binding site [chemical binding]; other site
425104001231	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
425104001232	SnoaL-like domain; Region: SnoaL_2; pfam12680
425104001233	glycerol kinase; Provisional; Region: glpK; PRK00047
425104001234	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
425104001235	N- and C-terminal domain interface [polypeptide binding]; other site
425104001236	active site
425104001237	MgATP binding site [chemical binding]; other site
425104001238	catalytic site [active]
425104001239	metal binding site [ion binding]; metal-binding site
425104001240	glycerol binding site [chemical binding]; other site
425104001241	homotetramer interface [polypeptide binding]; other site
425104001242	homodimer interface [polypeptide binding]; other site
425104001243	FBP binding site [chemical binding]; other site
425104001244	protein IIAGlc interface [polypeptide binding]; other site
425104001245	cell division protein MraZ; Reviewed; Region: PRK00326
425104001246	MraZ protein; Region: MraZ; pfam02381
425104001247	MraZ protein; Region: MraZ; pfam02381
425104001248	MraW methylase family; Region: Methyltransf_5; pfam01795
425104001249	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
425104001250	Cell division protein FtsL; Region: FtsL; pfam04999
425104001251	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
425104001252	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
425104001253	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
425104001254	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
425104001255	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
425104001256	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
425104001257	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
425104001258	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
425104001259	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
425104001260	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
425104001261	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
425104001262	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
425104001263	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
425104001264	Mg++ binding site [ion binding]; other site
425104001265	putative catalytic motif [active]
425104001266	putative substrate binding site [chemical binding]; other site
425104001267	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
425104001268	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
425104001269	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
425104001270	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
425104001271	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
425104001272	active site
425104001273	homodimer interface [polypeptide binding]; other site
425104001274	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
425104001275	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
425104001276	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
425104001277	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
425104001278	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
425104001279	Cell division protein FtsQ; Region: FtsQ; pfam03799
425104001280	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
425104001281	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
425104001282	nucleotide binding site [chemical binding]; other site
425104001283	Cell division protein FtsA; Region: FtsA; pfam14450
425104001284	cell division protein FtsZ; Validated; Region: PRK09330
425104001285	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
425104001286	nucleotide binding site [chemical binding]; other site
425104001287	SulA interaction site; other site
425104001288	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
425104001289	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
425104001290	Protein of unknown function (DUF721); Region: DUF721; cl02324
425104001291	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
425104001292	Peptidase family M23; Region: Peptidase_M23; pfam01551
425104001293	preprotein translocase subunit SecA; Reviewed; Region: PRK13107
425104001294	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
425104001295	SEC-C motif; Region: SEC-C; pfam02810
425104001296	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
425104001297	active site
425104001298	8-oxo-dGMP binding site [chemical binding]; other site
425104001299	nudix motif; other site
425104001300	metal binding site [ion binding]; metal-binding site
425104001301	Domain of unknown function (DUF329); Region: DUF329; pfam03884
425104001302	hypothetical protein; Provisional; Region: PRK05287
425104001303	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
425104001304	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
425104001305	CoA-binding site [chemical binding]; other site
425104001306	ATP-binding [chemical binding]; other site
425104001307	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
425104001308	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
425104001309	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
425104001310	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
425104001311	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
425104001312	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
425104001313	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
425104001314	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
425104001315	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
425104001316	Walker A motif; other site
425104001317	ATP binding site [chemical binding]; other site
425104001318	Walker B motif; other site
425104001319	putative major pilin subunit; Provisional; Region: PRK10574
425104001320	Pilin (bacterial filament); Region: Pilin; pfam00114
425104001321	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
425104001322	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
425104001323	dimerization interface [polypeptide binding]; other site
425104001324	active site
425104001325	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
425104001326	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
425104001327	amidase catalytic site [active]
425104001328	Zn binding residues [ion binding]; other site
425104001329	substrate binding site [chemical binding]; other site
425104001330	regulatory protein AmpE; Provisional; Region: PRK10987
425104001331	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
425104001332	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
425104001333	DNA-binding site [nucleotide binding]; DNA binding site
425104001334	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
425104001335	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
425104001336	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
425104001337	dimer interface [polypeptide binding]; other site
425104001338	TPP-binding site [chemical binding]; other site
425104001339	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
425104001340	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
425104001341	E3 interaction surface; other site
425104001342	lipoyl attachment site [posttranslational modification]; other site
425104001343	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
425104001344	E3 interaction surface; other site
425104001345	lipoyl attachment site [posttranslational modification]; other site
425104001346	e3 binding domain; Region: E3_binding; pfam02817
425104001347	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
425104001348	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
425104001349	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
425104001350	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
425104001351	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
425104001352	PAS fold; Region: PAS_3; pfam08447
425104001353	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
425104001354	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104001355	PAS domain; Region: PAS_9; pfam13426
425104001356	putative active site [active]
425104001357	heme pocket [chemical binding]; other site
425104001358	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104001359	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104001360	metal binding site [ion binding]; metal-binding site
425104001361	active site
425104001362	I-site; other site
425104001363	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104001364	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
425104001365	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
425104001366	active site
425104001367	nucleophile elbow; other site
425104001368	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
425104001369	Surface antigen; Region: Bac_surface_Ag; pfam01103
425104001370	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
425104001371	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
425104001372	active site
425104001373	Zn binding site [ion binding]; other site
425104001374	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
425104001375	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
425104001376	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104001377	motif II; other site
425104001378	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
425104001379	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
425104001380	substrate binding site [chemical binding]; other site
425104001381	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
425104001382	substrate binding site [chemical binding]; other site
425104001383	ligand binding site [chemical binding]; other site
425104001384	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
425104001385	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
425104001386	substrate binding site [chemical binding]; other site
425104001387	active site
425104001388	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104001389	PAS domain; Region: PAS_9; pfam13426
425104001390	putative active site [active]
425104001391	heme pocket [chemical binding]; other site
425104001392	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104001393	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104001394	metal binding site [ion binding]; metal-binding site
425104001395	active site
425104001396	I-site; other site
425104001397	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104001398	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
425104001399	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
425104001400	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
425104001401	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
425104001402	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
425104001403	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
425104001404	purine monophosphate binding site [chemical binding]; other site
425104001405	dimer interface [polypeptide binding]; other site
425104001406	putative catalytic residues [active]
425104001407	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
425104001408	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
425104001409	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
425104001410	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
425104001411	DNA binding residues [nucleotide binding]
425104001412	dimer interface [polypeptide binding]; other site
425104001413	metal binding site [ion binding]; metal-binding site
425104001414	Predicted permease; Region: DUF318; cl17795
425104001415	Predicted permease; Region: DUF318; cl17795
425104001416	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
425104001417	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
425104001418	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104001419	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
425104001420	hypothetical protein; Provisional; Region: PRK12378
425104001421	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104001422	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104001423	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104001424	putative effector binding pocket; other site
425104001425	dimerization interface [polypeptide binding]; other site
425104001426	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
425104001427	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104001428	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104001429	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
425104001430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104001431	putative substrate translocation pore; other site
425104001432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104001433	Autoinducer synthetase; Region: Autoind_synth; cl17404
425104001434	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104001435	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
425104001436	Coenzyme A binding pocket [chemical binding]; other site
425104001437	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
425104001438	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104001439	FeS/SAM binding site; other site
425104001440	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
425104001441	Conserved TM helix; Region: TM_helix; pfam05552
425104001442	Mechanosensitive ion channel; Region: MS_channel; pfam00924
425104001443	Protein of unknown function (DUF465); Region: DUF465; cl01070
425104001444	uridine phosphorylase; Provisional; Region: PRK11178
425104001445	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
425104001446	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
425104001447	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
425104001448	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
425104001449	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
425104001450	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
425104001451	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
425104001452	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
425104001453	homotrimer interaction site [polypeptide binding]; other site
425104001454	putative active site [active]
425104001455	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
425104001456	Part of AAA domain; Region: AAA_19; pfam13245
425104001457	Family description; Region: UvrD_C_2; pfam13538
425104001458	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
425104001459	UbiA prenyltransferase family; Region: UbiA; pfam01040
425104001460	putative transposase OrfB; Reviewed; Region: PHA02517
425104001461	HTH-like domain; Region: HTH_21; pfam13276
425104001462	Integrase core domain; Region: rve; pfam00665
425104001463	Integrase core domain; Region: rve_3; pfam13683
425104001464	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
425104001465	Transposase; Region: HTH_Tnp_1; cl17663
425104001466	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
425104001467	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
425104001468	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
425104001469	metal binding site [ion binding]; metal-binding site
425104001470	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
425104001471	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
425104001472	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104001473	Predicted transcriptional regulator [Transcription]; Region: COG3655
425104001474	sequence-specific DNA binding site [nucleotide binding]; other site
425104001475	salt bridge; other site
425104001476	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
425104001477	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
425104001478	catalytic residues [active]
425104001479	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
425104001480	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
425104001481	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
425104001482	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
425104001483	active site residue [active]
425104001484	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
425104001485	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
425104001486	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
425104001487	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
425104001488	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
425104001489	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
425104001490	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
425104001491	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
425104001492	NosL; Region: NosL; pfam05573
425104001493	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
425104001494	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
425104001495	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
425104001496	Walker A/P-loop; other site
425104001497	ATP binding site [chemical binding]; other site
425104001498	Q-loop/lid; other site
425104001499	ABC transporter signature motif; other site
425104001500	Walker B; other site
425104001501	D-loop; other site
425104001502	H-loop/switch region; other site
425104001503	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
425104001504	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
425104001505	DNA binding site [nucleotide binding]
425104001506	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
425104001507	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
425104001508	active site residue [active]
425104001509	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
425104001510	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
425104001511	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
425104001512	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
425104001513	binding surface
425104001514	TPR motif; other site
425104001515	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
425104001516	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
425104001517	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
425104001518	NosL; Region: NosL; pfam05573
425104001519	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
425104001520	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
425104001521	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
425104001522	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
425104001523	Walker A/P-loop; other site
425104001524	ATP binding site [chemical binding]; other site
425104001525	Q-loop/lid; other site
425104001526	ABC transporter signature motif; other site
425104001527	Walker B; other site
425104001528	D-loop; other site
425104001529	H-loop/switch region; other site
425104001530	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
425104001531	DNA binding site [nucleotide binding]
425104001532	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
425104001533	FMN reductase; Validated; Region: fre; PRK08051
425104001534	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
425104001535	FAD binding pocket [chemical binding]; other site
425104001536	FAD binding motif [chemical binding]; other site
425104001537	phosphate binding motif [ion binding]; other site
425104001538	beta-alpha-beta structure motif; other site
425104001539	NAD binding pocket [chemical binding]; other site
425104001540	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
425104001541	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
425104001542	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
425104001543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104001544	active site
425104001545	phosphorylation site [posttranslational modification]
425104001546	intermolecular recognition site; other site
425104001547	dimerization interface [polypeptide binding]; other site
425104001548	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
425104001549	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
425104001550	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
425104001551	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
425104001552	catalytic residues [active]
425104001553	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
425104001554	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104001555	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104001556	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
425104001557	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
425104001558	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
425104001559	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
425104001560	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
425104001561	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
425104001562	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
425104001563	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104001564	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104001565	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104001566	Domain of unknown function (DUF3859); Region: DUF3859; pfam12975
425104001567	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104001568	dimer interface [polypeptide binding]; other site
425104001569	putative CheW interface [polypeptide binding]; other site
425104001570	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
425104001571	Predicted amidohydrolase [General function prediction only]; Region: COG0388
425104001572	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
425104001573	putative active site [active]
425104001574	catalytic triad [active]
425104001575	putative dimer interface [polypeptide binding]; other site
425104001576	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
425104001577	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104001578	DNA binding residues [nucleotide binding]
425104001579	dimerization interface [polypeptide binding]; other site
425104001580	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
425104001581	heme-binding residues [chemical binding]; other site
425104001582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
425104001583	CHASE3 domain; Region: CHASE3; cl05000
425104001584	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104001585	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
425104001586	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104001587	dimer interface [polypeptide binding]; other site
425104001588	putative CheW interface [polypeptide binding]; other site
425104001589	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
425104001590	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104001591	Walker A motif; other site
425104001592	ATP binding site [chemical binding]; other site
425104001593	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
425104001594	Walker B motif; other site
425104001595	arginine finger; other site
425104001596	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
425104001597	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
425104001598	active site
425104001599	HslU subunit interaction site [polypeptide binding]; other site
425104001600	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
425104001601	Sporulation related domain; Region: SPOR; cl10051
425104001602	Sporulation related domain; Region: SPOR; pfam05036
425104001603	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
425104001604	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
425104001605	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
425104001606	active site
425104001607	HIGH motif; other site
425104001608	KMSK motif region; other site
425104001609	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
425104001610	tRNA binding surface [nucleotide binding]; other site
425104001611	anticodon binding site; other site
425104001612	primosome assembly protein PriA; Validated; Region: PRK05580
425104001613	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104001614	ATP binding site [chemical binding]; other site
425104001615	putative Mg++ binding site [ion binding]; other site
425104001616	helicase superfamily c-terminal domain; Region: HELICc; smart00490
425104001617	FimV N-terminal domain; Region: FimV_core; TIGR03505
425104001618	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
425104001619	Staphylococcal nuclease homologues; Region: SNc; smart00318
425104001620	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
425104001621	Catalytic site; other site
425104001622	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
425104001623	Malic enzyme, N-terminal domain; Region: malic; pfam00390
425104001624	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
425104001625	putative NAD(P) binding site [chemical binding]; other site
425104001626	regulatory protein CsrD; Provisional; Region: PRK11059
425104001627	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104001628	metal binding site [ion binding]; metal-binding site
425104001629	active site
425104001630	I-site; other site
425104001631	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104001632	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
425104001633	Pilus assembly protein, PilO; Region: PilO; cl01234
425104001634	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
425104001635	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
425104001636	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
425104001637	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
425104001638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104001639	Walker A motif; other site
425104001640	ATP binding site [chemical binding]; other site
425104001641	Walker B motif; other site
425104001642	arginine finger; other site
425104001643	Tetratricopeptide repeat; Region: TPR_16; pfam13432
425104001644	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104001645	TPR motif; other site
425104001646	binding surface
425104001647	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
425104001648	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
425104001649	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
425104001650	Walker A motif; other site
425104001651	ATP binding site [chemical binding]; other site
425104001652	Walker B motif; other site
425104001653	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
425104001654	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
425104001655	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
425104001656	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
425104001657	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
425104001658	Verru_Chthon cassette protein C; Region: TIGR02599
425104001659	rod shape-determining protein MreB; Provisional; Region: PRK13927
425104001660	MreB and similar proteins; Region: MreB_like; cd10225
425104001661	nucleotide binding site [chemical binding]; other site
425104001662	Mg binding site [ion binding]; other site
425104001663	putative protofilament interaction site [polypeptide binding]; other site
425104001664	RodZ interaction site [polypeptide binding]; other site
425104001665	rod shape-determining protein MreC; Region: mreC; TIGR00219
425104001666	rod shape-determining protein MreC; Region: MreC; pfam04085
425104001667	rod shape-determining protein MreD; Region: MreD; cl01087
425104001668	Maf-like protein; Region: Maf; pfam02545
425104001669	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
425104001670	active site
425104001671	dimer interface [polypeptide binding]; other site
425104001672	ribonuclease G; Provisional; Region: PRK11712
425104001673	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
425104001674	homodimer interface [polypeptide binding]; other site
425104001675	oligonucleotide binding site [chemical binding]; other site
425104001676	TIGR02099 family protein; Region: TIGR02099
425104001677	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
425104001678	nitrilase; Region: PLN02798
425104001679	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
425104001680	putative active site [active]
425104001681	catalytic triad [active]
425104001682	dimer interface [polypeptide binding]; other site
425104001683	protease TldD; Provisional; Region: tldD; PRK10735
425104001684	Outer membrane efflux protein; Region: OEP; pfam02321
425104001685	Outer membrane efflux protein; Region: OEP; pfam02321
425104001686	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
425104001687	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104001688	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104001689	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
425104001690	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
425104001691	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
425104001692	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
425104001693	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
425104001694	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
425104001695	hypothetical protein; Provisional; Region: PRK05255
425104001696	peptidase PmbA; Provisional; Region: PRK11040
425104001697	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
425104001698	dimerization interface [polypeptide binding]; other site
425104001699	putative DNA binding site [nucleotide binding]; other site
425104001700	putative Zn2+ binding site [ion binding]; other site
425104001701	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
425104001702	arsenical-resistance protein; Region: acr3; TIGR00832
425104001703	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
425104001704	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
425104001705	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
425104001706	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104001707	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104001708	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104001709	dimerization interface [polypeptide binding]; other site
425104001710	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
425104001711	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
425104001712	Chromate transporter; Region: Chromate_transp; pfam02417
425104001713	TPR repeat; Region: TPR_11; pfam13414
425104001714	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104001715	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104001716	metal binding site [ion binding]; metal-binding site
425104001717	active site
425104001718	I-site; other site
425104001719	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
425104001720	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104001721	Coenzyme A binding pocket [chemical binding]; other site
425104001722	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
425104001723	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
425104001724	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
425104001725	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
425104001726	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
425104001727	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
425104001728	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
425104001729	Walker A/P-loop; other site
425104001730	ATP binding site [chemical binding]; other site
425104001731	Q-loop/lid; other site
425104001732	ABC transporter signature motif; other site
425104001733	Walker B; other site
425104001734	D-loop; other site
425104001735	H-loop/switch region; other site
425104001736	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104001737	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
425104001738	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104001739	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104001740	dimer interface [polypeptide binding]; other site
425104001741	putative CheW interface [polypeptide binding]; other site
425104001742	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
425104001743	Helix-turn-helix domain; Region: HTH_18; pfam12833
425104001744	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
425104001745	FAD binding domain; Region: FAD_binding_4; pfam01565
425104001746	FAD dependent oxidoreductase; Region: DAO; pfam01266
425104001747	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
425104001748	uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779
425104001749	putative N- and C-terminal domain interface [polypeptide binding]; other site
425104001750	putative active site [active]
425104001751	MgATP binding site [chemical binding]; other site
425104001752	catalytic site [active]
425104001753	metal binding site [ion binding]; metal-binding site
425104001754	putative carbohydrate binding site [chemical binding]; other site
425104001755	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
425104001756	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
425104001757	IHF dimer interface [polypeptide binding]; other site
425104001758	IHF - DNA interface [nucleotide binding]; other site
425104001759	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
425104001760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104001761	active site
425104001762	phosphorylation site [posttranslational modification]
425104001763	intermolecular recognition site; other site
425104001764	dimerization interface [polypeptide binding]; other site
425104001765	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
425104001766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104001767	active site
425104001768	phosphorylation site [posttranslational modification]
425104001769	intermolecular recognition site; other site
425104001770	dimerization interface [polypeptide binding]; other site
425104001771	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
425104001772	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
425104001773	TraB family; Region: TraB; pfam01963
425104001774	CheD chemotactic sensory transduction; Region: CheD; cl00810
425104001775	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
425104001776	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
425104001777	active site 2 [active]
425104001778	active site 1 [active]
425104001779	formate--tetrahydrofolate ligase; Provisional; Region: PRK13506
425104001780	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
425104001781	Potassium binding sites [ion binding]; other site
425104001782	Cesium cation binding sites [ion binding]; other site
425104001783	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
425104001784	Mechanosensitive ion channel; Region: MS_channel; pfam00924
425104001785	Periplasmic binding protein TroA_c.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145
425104001786	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
425104001787	putative ligand binding site [chemical binding]; other site
425104001788	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
425104001789	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
425104001790	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
425104001791	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
425104001792	putative acyl-acceptor binding pocket; other site
425104001793	RNase E inhibitor protein; Provisional; Region: PRK11191
425104001794	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
425104001795	PAS fold; Region: PAS; pfam00989
425104001796	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104001797	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104001798	metal binding site [ion binding]; metal-binding site
425104001799	active site
425104001800	I-site; other site
425104001801	Response regulator receiver domain; Region: Response_reg; pfam00072
425104001802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104001803	active site
425104001804	phosphorylation site [posttranslational modification]
425104001805	intermolecular recognition site; other site
425104001806	dimerization interface [polypeptide binding]; other site
425104001807	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
425104001808	enoyl-CoA hydratase; Provisional; Region: PRK07509
425104001809	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
425104001810	substrate binding site [chemical binding]; other site
425104001811	oxyanion hole (OAH) forming residues; other site
425104001812	trimer interface [polypeptide binding]; other site
425104001813	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
425104001814	ATP-dependent helicase HepA; Validated; Region: PRK04914
425104001815	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104001816	ATP binding site [chemical binding]; other site
425104001817	putative Mg++ binding site [ion binding]; other site
425104001818	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104001819	nucleotide binding region [chemical binding]; other site
425104001820	ATP-binding site [chemical binding]; other site
425104001821	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
425104001822	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
425104001823	putative active site [active]
425104001824	PhoH-like protein; Region: PhoH; pfam02562
425104001825	Cache domain; Region: Cache_1; pfam02743
425104001826	PAS fold; Region: PAS_4; pfam08448
425104001827	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104001828	putative active site [active]
425104001829	heme pocket [chemical binding]; other site
425104001830	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104001831	PAS fold; Region: PAS_3; pfam08447
425104001832	putative active site [active]
425104001833	heme pocket [chemical binding]; other site
425104001834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104001835	dimer interface [polypeptide binding]; other site
425104001836	phosphorylation site [posttranslational modification]
425104001837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104001838	ATP binding site [chemical binding]; other site
425104001839	Mg2+ binding site [ion binding]; other site
425104001840	G-X-G motif; other site
425104001841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104001842	Response regulator receiver domain; Region: Response_reg; pfam00072
425104001843	active site
425104001844	phosphorylation site [posttranslational modification]
425104001845	intermolecular recognition site; other site
425104001846	dimerization interface [polypeptide binding]; other site
425104001847	Response regulator receiver domain; Region: Response_reg; pfam00072
425104001848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104001849	active site
425104001850	phosphorylation site [posttranslational modification]
425104001851	intermolecular recognition site; other site
425104001852	dimerization interface [polypeptide binding]; other site
425104001853	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
425104001854	active site
425104001855	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104001856	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104001857	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104001858	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104001859	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104001860	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104001861	putative effector binding pocket; other site
425104001862	dimerization interface [polypeptide binding]; other site
425104001863	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
425104001864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
425104001865	non-specific DNA binding site [nucleotide binding]; other site
425104001866	salt bridge; other site
425104001867	sequence-specific DNA binding site [nucleotide binding]; other site
425104001868	Cupin domain; Region: Cupin_2; pfam07883
425104001869	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
425104001870	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
425104001871	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
425104001872	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
425104001873	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
425104001874	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
425104001875	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
425104001876	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
425104001877	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
425104001878	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
425104001879	oligomerisation interface [polypeptide binding]; other site
425104001880	mobile loop; other site
425104001881	roof hairpin; other site
425104001882	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
425104001883	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
425104001884	ring oligomerisation interface [polypeptide binding]; other site
425104001885	ATP/Mg binding site [chemical binding]; other site
425104001886	stacking interactions; other site
425104001887	hinge regions; other site
425104001888	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104001889	AAA domain; Region: AAA_13; pfam13166
425104001890	Walker A/P-loop; other site
425104001891	ATP binding site [chemical binding]; other site
425104001892	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
425104001893	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104001894	ABC transporter signature motif; other site
425104001895	Walker B; other site
425104001896	D-loop; other site
425104001897	H-loop/switch region; other site
425104001898	HTH-like domain; Region: HTH_21; pfam13276
425104001899	Integrase core domain; Region: rve; pfam00665
425104001900	Integrase core domain; Region: rve_2; pfam13333
425104001901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
425104001902	Transposase; Region: HTH_Tnp_1; pfam01527
425104001903	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
425104001904	DNA-binding site [nucleotide binding]; DNA binding site
425104001905	RNA-binding motif; other site
425104001906	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
425104001907	This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein; Region: BCS1_N; smart01024
425104001908	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104001909	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
425104001910	Walker A motif; other site
425104001911	ATP binding site [chemical binding]; other site
425104001912	Walker B motif; other site
425104001913	arginine finger; other site
425104001914	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
425104001915	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
425104001916	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
425104001917	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
425104001918	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
425104001919	FMN-binding domain; Region: FMN_bind; cl01081
425104001920	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104001921	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104001922	substrate binding pocket [chemical binding]; other site
425104001923	membrane-bound complex binding site; other site
425104001924	hinge residues; other site
425104001925	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
425104001926	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
425104001927	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104001928	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296
425104001929	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
425104001930	ADP-ribose binding site [chemical binding]; other site
425104001931	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
425104001932	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
425104001933	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
425104001934	putative NAD(P) binding site [chemical binding]; other site
425104001935	homodimer interface [polypeptide binding]; other site
425104001936	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104001937	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104001938	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104001939	putative effector binding pocket; other site
425104001940	dimerization interface [polypeptide binding]; other site
425104001941	Surface antigen; Region: Bac_surface_Ag; pfam01103
425104001942	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
425104001943	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
425104001944	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
425104001945	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104001946	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104001947	ATP binding site [chemical binding]; other site
425104001948	Mg2+ binding site [ion binding]; other site
425104001949	G-X-G motif; other site
425104001950	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
425104001951	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
425104001952	urease accessory protein UreE; Provisional; Region: ureE; PRK13262
425104001953	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104001954	MFS transport protein AraJ; Provisional; Region: PRK10091
425104001955	putative substrate translocation pore; other site
425104001956	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104001957	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104001958	transcriptional activator TtdR; Provisional; Region: PRK09801
425104001959	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104001960	putative effector binding pocket; other site
425104001961	dimerization interface [polypeptide binding]; other site
425104001962	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
425104001963	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
425104001964	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
425104001965	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
425104001966	NAD binding site [chemical binding]; other site
425104001967	active site
425104001968	Protein of unknown function (DUF2999); Region: DUF2999; pfam11212
425104001969	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
425104001970	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
425104001971	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
425104001972	dimer interface [polypeptide binding]; other site
425104001973	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104001974	catalytic residue [active]
425104001975	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104001976	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104001977	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104001978	dimerization interface [polypeptide binding]; other site
425104001979	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104001980	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
425104001981	active site
425104001982	metal binding site [ion binding]; metal-binding site
425104001983	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
425104001984	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
425104001985	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
425104001986	substrate binding site [chemical binding]; other site
425104001987	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
425104001988	dimerization interface [polypeptide binding]; other site
425104001989	substrate binding site [chemical binding]; other site
425104001990	active site
425104001991	calcium binding site [ion binding]; other site
425104001992	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
425104001993	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
425104001994	MarR family; Region: MarR; pfam01047
425104001995	Response regulator receiver domain; Region: Response_reg; pfam00072
425104001996	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104001997	active site
425104001998	phosphorylation site [posttranslational modification]
425104001999	intermolecular recognition site; other site
425104002000	dimerization interface [polypeptide binding]; other site
425104002001	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
425104002002	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
425104002003	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
425104002004	putative dimer interface [polypeptide binding]; other site
425104002005	NnrS protein; Region: NnrS; pfam05940
425104002006	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
425104002007	Major Facilitator Superfamily; Region: MFS_1; pfam07690
425104002008	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104002009	putative substrate translocation pore; other site
425104002010	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
425104002011	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104002012	dimerization interface [polypeptide binding]; other site
425104002013	DNA binding residues [nucleotide binding]
425104002014	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
425104002015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104002016	active site
425104002017	phosphorylation site [posttranslational modification]
425104002018	intermolecular recognition site; other site
425104002019	dimerization interface [polypeptide binding]; other site
425104002020	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
425104002021	DNA binding site [nucleotide binding]
425104002022	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104002023	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
425104002024	Mg2+ binding site [ion binding]; other site
425104002025	G-X-G motif; other site
425104002026	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
425104002027	FMN-binding domain; Region: FMN_bind; pfam04205
425104002028	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
425104002029	L-aspartate oxidase; Provisional; Region: PRK06175
425104002030	Predicted oxidoreductase [General function prediction only]; Region: COG3573
425104002031	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
425104002032	ApbE family; Region: ApbE; pfam02424
425104002033	PBP superfamily domain; Region: PBP_like_2; cl17296
425104002034	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
425104002035	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104002036	ABC-ATPase subunit interface; other site
425104002037	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104002038	dimer interface [polypeptide binding]; other site
425104002039	conserved gate region; other site
425104002040	putative PBP binding loops; other site
425104002041	ABC-ATPase subunit interface; other site
425104002042	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
425104002043	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
425104002044	Walker A/P-loop; other site
425104002045	ATP binding site [chemical binding]; other site
425104002046	Q-loop/lid; other site
425104002047	ABC transporter signature motif; other site
425104002048	Walker B; other site
425104002049	D-loop; other site
425104002050	H-loop/switch region; other site
425104002051	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
425104002052	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
425104002053	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104002054	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
425104002055	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
425104002056	fumarate hydratase; Reviewed; Region: fumC; PRK00485
425104002057	Class II fumarases; Region: Fumarase_classII; cd01362
425104002058	active site
425104002059	tetramer interface [polypeptide binding]; other site
425104002060	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
425104002061	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
425104002062	putative RNA binding site [nucleotide binding]; other site
425104002063	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104002064	S-adenosylmethionine binding site [chemical binding]; other site
425104002065	Putative serine esterase (DUF676); Region: DUF676; pfam05057
425104002066	Predicted permeases [General function prediction only]; Region: RarD; COG2962
425104002067	EamA-like transporter family; Region: EamA; pfam00892
425104002068	Family description; Region: VCBS; pfam13517
425104002069	Family description; Region: VCBS; pfam13517
425104002070	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
425104002071	non-specific DNA binding site [nucleotide binding]; other site
425104002072	salt bridge; other site
425104002073	sequence-specific DNA binding site [nucleotide binding]; other site
425104002074	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
425104002075	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
425104002076	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
425104002077	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104002078	dimer interface [polypeptide binding]; other site
425104002079	phosphorylation site [posttranslational modification]
425104002080	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104002081	ATP binding site [chemical binding]; other site
425104002082	G-X-G motif; other site
425104002083	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
425104002084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104002085	active site
425104002086	phosphorylation site [posttranslational modification]
425104002087	intermolecular recognition site; other site
425104002088	dimerization interface [polypeptide binding]; other site
425104002089	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104002090	DNA binding site [nucleotide binding]
425104002091	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
425104002092	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
425104002093	Ligand binding site; other site
425104002094	Putative Catalytic site; other site
425104002095	DXD motif; other site
425104002096	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
425104002097	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
425104002098	Predicted membrane protein [Function unknown]; Region: COG2246
425104002099	GtrA-like protein; Region: GtrA; pfam04138
425104002100	putative outer membrane lipoprotein; Provisional; Region: PRK10510
425104002101	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
425104002102	ligand binding site [chemical binding]; other site
425104002103	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551
425104002104	active site
425104002105	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
425104002106	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
425104002107	MgtE intracellular N domain; Region: MgtE_N; smart00924
425104002108	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
425104002109	Divalent cation transporter; Region: MgtE; cl00786
425104002110	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
425104002111	dimerization domain swap beta strand [polypeptide binding]; other site
425104002112	regulatory protein interface [polypeptide binding]; other site
425104002113	active site
425104002114	regulatory phosphorylation site [posttranslational modification]; other site
425104002115	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
425104002116	AAA domain; Region: AAA_18; pfam13238
425104002117	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
425104002118	active site
425104002119	phosphorylation site [posttranslational modification]
425104002120	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
425104002121	30S subunit binding site; other site
425104002122	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
425104002123	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
425104002124	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
425104002125	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
425104002126	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
425104002127	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
425104002128	Walker A/P-loop; other site
425104002129	ATP binding site [chemical binding]; other site
425104002130	Q-loop/lid; other site
425104002131	ABC transporter signature motif; other site
425104002132	Walker B; other site
425104002133	D-loop; other site
425104002134	H-loop/switch region; other site
425104002135	OstA-like protein; Region: OstA; cl00844
425104002136	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
425104002137	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
425104002138	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
425104002139	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
425104002140	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
425104002141	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
425104002142	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
425104002143	putative active site [active]
425104002144	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
425104002145	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
425104002146	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
425104002147	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
425104002148	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
425104002149	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
425104002150	Walker A/P-loop; other site
425104002151	ATP binding site [chemical binding]; other site
425104002152	Q-loop/lid; other site
425104002153	ABC transporter signature motif; other site
425104002154	Walker B; other site
425104002155	D-loop; other site
425104002156	H-loop/switch region; other site
425104002157	conserved hypothetical integral membrane protein; Region: TIGR00056
425104002158	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
425104002159	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
425104002160	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
425104002161	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
425104002162	anti sigma factor interaction site; other site
425104002163	regulatory phosphorylation site [posttranslational modification]; other site
425104002164	BolA-like protein; Region: BolA; cl00386
425104002165	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
425104002166	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
425104002167	hinge; other site
425104002168	active site
425104002169	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104002170	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104002171	dimer interface [polypeptide binding]; other site
425104002172	phosphorylation site [posttranslational modification]
425104002173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104002174	ATP binding site [chemical binding]; other site
425104002175	Mg2+ binding site [ion binding]; other site
425104002176	G-X-G motif; other site
425104002177	Response regulator receiver domain; Region: Response_reg; pfam00072
425104002178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104002179	active site
425104002180	phosphorylation site [posttranslational modification]
425104002181	intermolecular recognition site; other site
425104002182	dimerization interface [polypeptide binding]; other site
425104002183	dimerization interface [polypeptide binding]; other site
425104002184	putative DNA binding site [nucleotide binding]; other site
425104002185	Helix-turn-helix domain; Region: HTH_20; pfam12840
425104002186	putative Zn2+ binding site [ion binding]; other site
425104002187	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104002188	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
425104002189	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
425104002190	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
425104002191	protein binding site [polypeptide binding]; other site
425104002192	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
425104002193	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
425104002194	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
425104002195	protein binding site [polypeptide binding]; other site
425104002196	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
425104002197	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
425104002198	Predicted ATPase [General function prediction only]; Region: COG1485
425104002199	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
425104002200	23S rRNA interface [nucleotide binding]; other site
425104002201	L3 interface [polypeptide binding]; other site
425104002202	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
425104002203	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
425104002204	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
425104002205	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
425104002206	GDP-binding site [chemical binding]; other site
425104002207	ACT binding site; other site
425104002208	IMP binding site; other site
425104002209	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
425104002210	Sel1 repeat; Region: Sel1; cl02723
425104002211	exoribonuclease R; Provisional; Region: PRK11642
425104002212	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
425104002213	RNB domain; Region: RNB; pfam00773
425104002214	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
425104002215	RNA binding site [nucleotide binding]; other site
425104002216	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
425104002217	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
425104002218	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
425104002219	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879
425104002220	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
425104002221	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104002222	dimerization interface [polypeptide binding]; other site
425104002223	DNA binding residues [nucleotide binding]
425104002224	Protein of unknown function, DUF481; Region: DUF481; pfam04338
425104002225	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
425104002226	primosomal replication protein N; Provisional; Region: PRK02801
425104002227	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
425104002228	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
425104002229	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
425104002230	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
425104002231	Peptidase S46; Region: Peptidase_S46; pfam10459
425104002232	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
425104002233	replicative DNA helicase; Provisional; Region: PRK08840
425104002234	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
425104002235	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
425104002236	Walker A motif; other site
425104002237	ATP binding site [chemical binding]; other site
425104002238	Walker B motif; other site
425104002239	DNA binding loops [nucleotide binding]
425104002240	alanine racemase; Reviewed; Region: alr; PRK00053
425104002241	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
425104002242	active site
425104002243	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
425104002244	substrate binding site [chemical binding]; other site
425104002245	catalytic residues [active]
425104002246	dimer interface [polypeptide binding]; other site
425104002247	Surface antigen; Region: Bac_surface_Ag; pfam01103
425104002248	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
425104002249	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
425104002250	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
425104002251	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
425104002252	FMN binding site [chemical binding]; other site
425104002253	active site
425104002254	catalytic residues [active]
425104002255	substrate binding site [chemical binding]; other site
425104002256	PspC domain; Region: PspC; pfam04024
425104002257	enoyl-CoA hydratase; Provisional; Region: PRK06688
425104002258	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
425104002259	substrate binding site [chemical binding]; other site
425104002260	oxyanion hole (OAH) forming residues; other site
425104002261	trimer interface [polypeptide binding]; other site
425104002262	Protein of unknown function (DUF461); Region: DUF461; pfam04314
425104002263	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
425104002264	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
425104002265	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
425104002266	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
425104002267	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
425104002268	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
425104002269	dimer interface [polypeptide binding]; other site
425104002270	ADP-ribose binding site [chemical binding]; other site
425104002271	active site
425104002272	nudix motif; other site
425104002273	metal binding site [ion binding]; metal-binding site
425104002274	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
425104002275	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
425104002276	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
425104002277	active site
425104002278	metal binding site [ion binding]; metal-binding site
425104002279	hexamer interface [polypeptide binding]; other site
425104002280	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
425104002281	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
425104002282	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
425104002283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104002284	ATP binding site [chemical binding]; other site
425104002285	Mg2+ binding site [ion binding]; other site
425104002286	G-X-G motif; other site
425104002287	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
425104002288	anchoring element; other site
425104002289	dimer interface [polypeptide binding]; other site
425104002290	ATP binding site [chemical binding]; other site
425104002291	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
425104002292	active site
425104002293	metal binding site [ion binding]; metal-binding site
425104002294	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
425104002295	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
425104002296	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
425104002297	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
425104002298	CAP-like domain; other site
425104002299	active site
425104002300	primary dimer interface [polypeptide binding]; other site
425104002301	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
425104002302	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
425104002303	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
425104002304	NAD binding site [chemical binding]; other site
425104002305	ligand binding site [chemical binding]; other site
425104002306	catalytic site [active]
425104002307	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
425104002308	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
425104002309	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
425104002310	active site
425104002311	catalytic site [active]
425104002312	putative mechanosensitive channel protein; Provisional; Region: PRK10929
425104002313	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
425104002314	Mechanosensitive ion channel; Region: MS_channel; pfam00924
425104002315	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
425104002316	EamA-like transporter family; Region: EamA; pfam00892
425104002317	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
425104002318	GTPase RsgA; Reviewed; Region: PRK12288
425104002319	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
425104002320	RNA binding site [nucleotide binding]; other site
425104002321	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
425104002322	GTPase/Zn-binding domain interface [polypeptide binding]; other site
425104002323	GTP/Mg2+ binding site [chemical binding]; other site
425104002324	G4 box; other site
425104002325	G5 box; other site
425104002326	G1 box; other site
425104002327	Switch I region; other site
425104002328	G2 box; other site
425104002329	G3 box; other site
425104002330	Switch II region; other site
425104002331	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
425104002332	catalytic site [active]
425104002333	putative active site [active]
425104002334	putative substrate binding site [chemical binding]; other site
425104002335	dimer interface [polypeptide binding]; other site
425104002336	putative carbohydrate kinase; Provisional; Region: PRK10565
425104002337	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
425104002338	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
425104002339	putative substrate binding site [chemical binding]; other site
425104002340	putative ATP binding site [chemical binding]; other site
425104002341	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
425104002342	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
425104002343	AMIN domain; Region: AMIN; pfam11741
425104002344	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
425104002345	active site
425104002346	metal binding site [ion binding]; metal-binding site
425104002347	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
425104002348	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
425104002349	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104002350	Mg2+ binding site [ion binding]; other site
425104002351	G-X-G motif; other site
425104002352	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
425104002353	ATP binding site [chemical binding]; other site
425104002354	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
425104002355	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
425104002356	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
425104002357	bacterial Hfq-like; Region: Hfq; cd01716
425104002358	hexamer interface [polypeptide binding]; other site
425104002359	Sm1 motif; other site
425104002360	RNA binding site [nucleotide binding]; other site
425104002361	Sm2 motif; other site
425104002362	GTPase HflX; Provisional; Region: PRK11058
425104002363	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
425104002364	HflX GTPase family; Region: HflX; cd01878
425104002365	G1 box; other site
425104002366	GTP/Mg2+ binding site [chemical binding]; other site
425104002367	Switch I region; other site
425104002368	G2 box; other site
425104002369	G3 box; other site
425104002370	Switch II region; other site
425104002371	G4 box; other site
425104002372	G5 box; other site
425104002373	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
425104002374	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
425104002375	HflK protein; Region: hflK; TIGR01933
425104002376	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
425104002377	FtsH protease regulator HflC; Provisional; Region: PRK11029
425104002378	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
425104002379	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
425104002380	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
425104002381	[2Fe-2S] cluster binding site [ion binding]; other site
425104002382	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
425104002383	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
425104002384	Qi binding site; other site
425104002385	intrachain domain interface; other site
425104002386	interchain domain interface [polypeptide binding]; other site
425104002387	heme bH binding site [chemical binding]; other site
425104002388	heme bL binding site [chemical binding]; other site
425104002389	Qo binding site; other site
425104002390	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
425104002391	interchain domain interface [polypeptide binding]; other site
425104002392	intrachain domain interface; other site
425104002393	Qi binding site; other site
425104002394	Qo binding site; other site
425104002395	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
425104002396	stringent starvation protein A; Provisional; Region: sspA; PRK09481
425104002397	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
425104002398	C-terminal domain interface [polypeptide binding]; other site
425104002399	putative GSH binding site (G-site) [chemical binding]; other site
425104002400	dimer interface [polypeptide binding]; other site
425104002401	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
425104002402	dimer interface [polypeptide binding]; other site
425104002403	N-terminal domain interface [polypeptide binding]; other site
425104002404	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
425104002405	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
425104002406	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
425104002407	glutamine binding [chemical binding]; other site
425104002408	catalytic triad [active]
425104002409	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
425104002410	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104002411	HDOD domain; Region: HDOD; pfam08668
425104002412	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
425104002413	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
425104002414	inhibitor-cofactor binding pocket; inhibition site
425104002415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104002416	catalytic residue [active]
425104002417	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
425104002418	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
425104002419	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
425104002420	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
425104002421	NAD(P) binding site [chemical binding]; other site
425104002422	catalytic residues [active]
425104002423	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
425104002424	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
425104002425	AMP binding site [chemical binding]; other site
425104002426	metal binding site [ion binding]; metal-binding site
425104002427	active site
425104002428	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
425104002429	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
425104002430	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104002431	two-component response regulator; Provisional; Region: PRK11173
425104002432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104002433	active site
425104002434	phosphorylation site [posttranslational modification]
425104002435	intermolecular recognition site; other site
425104002436	dimerization interface [polypeptide binding]; other site
425104002437	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104002438	DNA binding site [nucleotide binding]
425104002439	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
425104002440	aspartate kinase III; Validated; Region: PRK09084
425104002441	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
425104002442	nucleotide binding site [chemical binding]; other site
425104002443	substrate binding site [chemical binding]; other site
425104002444	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
425104002445	dimer interface [polypeptide binding]; other site
425104002446	allosteric regulatory binding pocket; other site
425104002447	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
425104002448	dimer interface [polypeptide binding]; other site
425104002449	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
425104002450	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
425104002451	active site
425104002452	Zn binding site [ion binding]; other site
425104002453	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
425104002454	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
425104002455	active site
425104002456	catalytic residues [active]
425104002457	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
425104002458	PA/protease or protease-like domain interface [polypeptide binding]; other site
425104002459	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
425104002460	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
425104002461	GlyGly-CTERM domain; Region: GlyGly_CTERM; TIGR03501
425104002462	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
425104002463	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
425104002464	putative DNA binding site [nucleotide binding]; other site
425104002465	putative Zn2+ binding site [ion binding]; other site
425104002466	AsnC family; Region: AsnC_trans_reg; pfam01037
425104002467	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
425104002468	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
425104002469	active site
425104002470	tellurite resistance protein TehB; Provisional; Region: PRK11207
425104002471	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104002472	S-adenosylmethionine binding site [chemical binding]; other site
425104002473	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
425104002474	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
425104002475	putative ligand binding site [chemical binding]; other site
425104002476	putative NAD binding site [chemical binding]; other site
425104002477	catalytic site [active]
425104002478	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
425104002479	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
425104002480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104002481	peroxiredoxin; Region: AhpC; TIGR03137
425104002482	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
425104002483	dimer interface [polypeptide binding]; other site
425104002484	decamer (pentamer of dimers) interface [polypeptide binding]; other site
425104002485	catalytic triad [active]
425104002486	peroxidatic and resolving cysteines [active]
425104002487	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
425104002488	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
425104002489	catalytic residue [active]
425104002490	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
425104002491	catalytic residues [active]
425104002492	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
425104002493	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
425104002494	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104002495	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104002496	metal binding site [ion binding]; metal-binding site
425104002497	active site
425104002498	I-site; other site
425104002499	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
425104002500	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
425104002501	MarR family; Region: MarR; pfam01047
425104002502	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
425104002503	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
425104002504	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104002505	dimerization interface [polypeptide binding]; other site
425104002506	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104002507	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104002508	dimer interface [polypeptide binding]; other site
425104002509	putative CheW interface [polypeptide binding]; other site
425104002510	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
425104002511	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
425104002512	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
425104002513	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
425104002514	4Fe-4S binding domain; Region: Fer4; pfam00037
425104002515	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
425104002516	4Fe-4S binding domain; Region: Fer4; pfam00037
425104002517	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
425104002518	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
425104002519	[4Fe-4S] binding site [ion binding]; other site
425104002520	molybdopterin cofactor binding site; other site
425104002521	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
425104002522	molybdopterin cofactor binding site; other site
425104002523	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
425104002524	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
425104002525	Ion channel; Region: Ion_trans_2; pfam07885
425104002526	peptide chain release factor 2; Validated; Region: prfB; PRK00578
425104002527	This domain is found in peptide chain release factors; Region: PCRF; smart00937
425104002528	RF-1 domain; Region: RF-1; pfam00472
425104002529	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
425104002530	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
425104002531	dimer interface [polypeptide binding]; other site
425104002532	putative anticodon binding site; other site
425104002533	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
425104002534	motif 1; other site
425104002535	active site
425104002536	motif 2; other site
425104002537	motif 3; other site
425104002538	PAS domain S-box; Region: sensory_box; TIGR00229
425104002539	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104002540	putative active site [active]
425104002541	heme pocket [chemical binding]; other site
425104002542	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104002543	PAS domain; Region: PAS_9; pfam13426
425104002544	putative active site [active]
425104002545	heme pocket [chemical binding]; other site
425104002546	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104002547	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104002548	metal binding site [ion binding]; metal-binding site
425104002549	active site
425104002550	I-site; other site
425104002551	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104002552	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
425104002553	pseudouridine synthase; Region: TIGR00093
425104002554	active site
425104002555	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
425104002556	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
425104002557	active site
425104002558	trimer interface [polypeptide binding]; other site
425104002559	allosteric site; other site
425104002560	active site lid [active]
425104002561	hexamer (dimer of trimers) interface [polypeptide binding]; other site
425104002562	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
425104002563	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
425104002564	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104002565	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104002566	metal binding site [ion binding]; metal-binding site
425104002567	active site
425104002568	I-site; other site
425104002569	Cupin domain; Region: Cupin_2; pfam07883
425104002570	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
425104002571	Peptidase family U32; Region: Peptidase_U32; pfam01136
425104002572	Collagenase; Region: DUF3656; pfam12392
425104002573	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
425104002574	pentamer interface [polypeptide binding]; other site
425104002575	dodecaamer interface [polypeptide binding]; other site
425104002576	Predicted ATPase [General function prediction only]; Region: COG4637
425104002577	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104002578	Walker A/P-loop; other site
425104002579	ATP binding site [chemical binding]; other site
425104002580	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
425104002581	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
425104002582	TPR repeat; Region: TPR_11; pfam13414
425104002583	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104002584	binding surface
425104002585	TPR motif; other site
425104002586	TPR repeat; Region: TPR_11; pfam13414
425104002587	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104002588	TPR motif; other site
425104002589	TPR repeat; Region: TPR_11; pfam13414
425104002590	binding surface
425104002591	Uncharacterized conserved protein [Function unknown]; Region: COG1359
425104002592	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
425104002593	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
425104002594	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
425104002595	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
425104002596	catalytic residue [active]
425104002597	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
425104002598	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
425104002599	active site
425104002600	catalytic tetrad [active]
425104002601	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
425104002602	MarR family; Region: MarR_2; pfam12802
425104002603	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104002604	Coenzyme A binding pocket [chemical binding]; other site
425104002605	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
425104002606	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
425104002607	serine transporter; Region: stp; TIGR00814
425104002608	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
425104002609	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
425104002610	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
425104002611	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
425104002612	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104002613	Coenzyme A binding pocket [chemical binding]; other site
425104002614	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
425104002615	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
425104002616	META domain; Region: META; pfam03724
425104002617	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
425104002618	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
425104002619	metal binding site [ion binding]; metal-binding site
425104002620	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104002621	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104002622	metal binding site [ion binding]; metal-binding site
425104002623	active site
425104002624	I-site; other site
425104002625	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
425104002626	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104002627	DNA binding residues [nucleotide binding]
425104002628	dimerization interface [polypeptide binding]; other site
425104002629	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
425104002630	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
425104002631	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
425104002632	PYR/PP interface [polypeptide binding]; other site
425104002633	dimer interface [polypeptide binding]; other site
425104002634	TPP binding site [chemical binding]; other site
425104002635	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
425104002636	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
425104002637	TPP-binding site [chemical binding]; other site
425104002638	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
425104002639	S-adenosylmethionine synthetase; Validated; Region: PRK05250
425104002640	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
425104002641	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
425104002642	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
425104002643	transketolase; Reviewed; Region: PRK12753
425104002644	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
425104002645	TPP-binding site [chemical binding]; other site
425104002646	dimer interface [polypeptide binding]; other site
425104002647	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
425104002648	PYR/PP interface [polypeptide binding]; other site
425104002649	dimer interface [polypeptide binding]; other site
425104002650	TPP binding site [chemical binding]; other site
425104002651	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
425104002652	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
425104002653	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
425104002654	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
425104002655	Phosphoglycerate kinase; Region: PGK; pfam00162
425104002656	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
425104002657	substrate binding site [chemical binding]; other site
425104002658	hinge regions; other site
425104002659	ADP binding site [chemical binding]; other site
425104002660	catalytic site [active]
425104002661	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
425104002662	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
425104002663	intersubunit interface [polypeptide binding]; other site
425104002664	active site
425104002665	zinc binding site [ion binding]; other site
425104002666	Na+ binding site [ion binding]; other site
425104002667	Protein of unknown function, DUF481; Region: DUF481; pfam04338
425104002668	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
425104002669	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
425104002670	DNA binding site [nucleotide binding]
425104002671	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104002672	PAS domain; Region: PAS_9; pfam13426
425104002673	putative active site [active]
425104002674	heme pocket [chemical binding]; other site
425104002675	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104002676	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104002677	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
425104002678	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104002679	FeS/SAM binding site; other site
425104002680	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104002681	Protein export membrane protein; Region: SecD_SecF; cl14618
425104002682	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104002683	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104002684	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
425104002685	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
425104002686	ATP binding site [chemical binding]; other site
425104002687	Mg++ binding site [ion binding]; other site
425104002688	motif III; other site
425104002689	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104002690	nucleotide binding region [chemical binding]; other site
425104002691	ATP-binding site [chemical binding]; other site
425104002692	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
425104002693	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104002694	S-adenosylmethionine binding site [chemical binding]; other site
425104002695	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
425104002696	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
425104002697	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
425104002698	active site
425104002699	Int/Topo IB signature motif; other site
425104002700	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
425104002701	dimerization domain [polypeptide binding]; other site
425104002702	dimer interface [polypeptide binding]; other site
425104002703	catalytic residues [active]
425104002704	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
425104002705	DHH family; Region: DHH; pfam01368
425104002706	DHHA1 domain; Region: DHHA1; pfam02272
425104002707	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104002708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104002709	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
425104002710	putative dimerization interface [polypeptide binding]; other site
425104002711	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
425104002712	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
425104002713	tetramer (dimer of dimers) interface [polypeptide binding]; other site
425104002714	active site
425104002715	dimer interface [polypeptide binding]; other site
425104002716	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
425104002717	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104002718	Zn2+ binding site [ion binding]; other site
425104002719	Mg2+ binding site [ion binding]; other site
425104002720	Protein of unknown function (DUF808); Region: DUF808; pfam05661
425104002721	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104002722	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104002723	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104002724	dimerization interface [polypeptide binding]; other site
425104002725	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
425104002726	LrgB-like family; Region: LrgB; pfam04172
425104002727	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
425104002728	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104002729	active site
425104002730	phosphorylation site [posttranslational modification]
425104002731	intermolecular recognition site; other site
425104002732	dimerization interface [polypeptide binding]; other site
425104002733	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104002734	DNA binding residues [nucleotide binding]
425104002735	dimerization interface [polypeptide binding]; other site
425104002736	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
425104002737	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
425104002738	Histidine kinase; Region: HisKA_3; pfam07730
425104002739	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104002740	ATP binding site [chemical binding]; other site
425104002741	Mg2+ binding site [ion binding]; other site
425104002742	G-X-G motif; other site
425104002743	L-lactate permease; Region: Lactate_perm; cl00701
425104002744	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
425104002745	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
425104002746	FAD binding domain; Region: FAD_binding_4; pfam01565
425104002747	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
425104002748	FOG: CBS domain [General function prediction only]; Region: COG0517
425104002749	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
425104002750	PhoD-like phosphatase; Region: PhoD; pfam09423
425104002751	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
425104002752	putative active site [active]
425104002753	putative metal binding site [ion binding]; other site
425104002754	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
425104002755	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
425104002756	active site
425104002757	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
425104002758	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
425104002759	Zn binding site [ion binding]; other site
425104002760	uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722
425104002761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
425104002762	SlyX; Region: SlyX; pfam04102
425104002763	FOG: WD40 repeat [General function prediction only]; Region: COG2319
425104002764	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
425104002765	structural tetrad; other site
425104002766	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
425104002767	structural tetrad; other site
425104002768	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
425104002769	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
425104002770	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
425104002771	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
425104002772	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
425104002773	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
425104002774	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
425104002775	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
425104002776	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
425104002777	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
425104002778	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
425104002779	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
425104002780	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
425104002781	putative active site [active]
425104002782	putative catalytic site [active]
425104002783	putative Zn binding site [ion binding]; other site
425104002784	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
425104002785	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
425104002786	active site
425104002787	substrate binding site [chemical binding]; other site
425104002788	cosubstrate binding site; other site
425104002789	catalytic site [active]
425104002790	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
425104002791	active site
425104002792	hexamer interface [polypeptide binding]; other site
425104002793	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
425104002794	NAD binding site [chemical binding]; other site
425104002795	substrate binding site [chemical binding]; other site
425104002796	active site
425104002797	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
425104002798	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
425104002799	Ligand binding site; other site
425104002800	Putative Catalytic site; other site
425104002801	DXD motif; other site
425104002802	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
425104002803	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
425104002804	inhibitor-cofactor binding pocket; inhibition site
425104002805	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104002806	catalytic residue [active]
425104002807	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
425104002808	Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062
425104002809	transcriptional regulator NarL; Provisional; Region: PRK10651
425104002810	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104002811	active site
425104002812	phosphorylation site [posttranslational modification]
425104002813	intermolecular recognition site; other site
425104002814	dimerization interface [polypeptide binding]; other site
425104002815	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104002816	DNA binding residues [nucleotide binding]
425104002817	dimerization interface [polypeptide binding]; other site
425104002818	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
425104002819	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
425104002820	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104002821	dimerization interface [polypeptide binding]; other site
425104002822	Histidine kinase; Region: HisKA_3; pfam07730
425104002823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104002824	ATP binding site [chemical binding]; other site
425104002825	Mg2+ binding site [ion binding]; other site
425104002826	G-X-G motif; other site
425104002827	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
425104002828	Isochorismatase family; Region: Isochorismatase; pfam00857
425104002829	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
425104002830	catalytic triad [active]
425104002831	dimer interface [polypeptide binding]; other site
425104002832	conserved cis-peptide bond; other site
425104002833	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
425104002834	Nitrogen regulatory protein P-II; Region: P-II; smart00938
425104002835	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
425104002836	Tetratricopeptide repeat; Region: TPR_12; pfam13424
425104002837	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104002838	binding surface
425104002839	TPR motif; other site
425104002840	TPR repeat; Region: TPR_11; pfam13414
425104002841	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
425104002842	binding surface
425104002843	TPR motif; other site
425104002844	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
425104002845	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
425104002846	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
425104002847	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
425104002848	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104002849	Walker A/P-loop; other site
425104002850	ATP binding site [chemical binding]; other site
425104002851	Q-loop/lid; other site
425104002852	ABC transporter signature motif; other site
425104002853	Walker B; other site
425104002854	D-loop; other site
425104002855	H-loop/switch region; other site
425104002856	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
425104002857	catalytic core [active]
425104002858	ferredoxin-NADP reductase; Provisional; Region: PRK10926
425104002859	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
425104002860	FAD binding pocket [chemical binding]; other site
425104002861	FAD binding motif [chemical binding]; other site
425104002862	phosphate binding motif [ion binding]; other site
425104002863	beta-alpha-beta structure motif; other site
425104002864	NAD binding pocket [chemical binding]; other site
425104002865	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
425104002866	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
425104002867	putative C-terminal domain interface [polypeptide binding]; other site
425104002868	putative GSH binding site (G-site) [chemical binding]; other site
425104002869	putative dimer interface [polypeptide binding]; other site
425104002870	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
425104002871	dimer interface [polypeptide binding]; other site
425104002872	N-terminal domain interface [polypeptide binding]; other site
425104002873	putative substrate binding pocket (H-site) [chemical binding]; other site
425104002874	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
425104002875	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
425104002876	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
425104002877	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104002878	dimer interface [polypeptide binding]; other site
425104002879	conserved gate region; other site
425104002880	putative PBP binding loops; other site
425104002881	ABC-ATPase subunit interface; other site
425104002882	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104002883	dimer interface [polypeptide binding]; other site
425104002884	conserved gate region; other site
425104002885	putative PBP binding loops; other site
425104002886	ABC-ATPase subunit interface; other site
425104002887	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
425104002888	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
425104002889	Walker A/P-loop; other site
425104002890	ATP binding site [chemical binding]; other site
425104002891	Q-loop/lid; other site
425104002892	ABC transporter signature motif; other site
425104002893	Walker B; other site
425104002894	D-loop; other site
425104002895	H-loop/switch region; other site
425104002896	TOBE domain; Region: TOBE_2; pfam08402
425104002897	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
425104002898	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
425104002899	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
425104002900	Cupin domain; Region: Cupin_2; cl17218
425104002901	arginine repressor; Provisional; Region: PRK05066
425104002902	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
425104002903	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
425104002904	malate dehydrogenase; Provisional; Region: PRK05086
425104002905	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
425104002906	NAD binding site [chemical binding]; other site
425104002907	dimerization interface [polypeptide binding]; other site
425104002908	Substrate binding site [chemical binding]; other site
425104002909	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
425104002910	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
425104002911	substrate binding pocket [chemical binding]; other site
425104002912	chain length determination region; other site
425104002913	substrate-Mg2+ binding site; other site
425104002914	catalytic residues [active]
425104002915	aspartate-rich region 1; other site
425104002916	active site lid residues [active]
425104002917	aspartate-rich region 2; other site
425104002918	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
425104002919	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
425104002920	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
425104002921	GTPase CgtA; Reviewed; Region: obgE; PRK12298
425104002922	GTP1/OBG; Region: GTP1_OBG; pfam01018
425104002923	Obg GTPase; Region: Obg; cd01898
425104002924	G1 box; other site
425104002925	GTP/Mg2+ binding site [chemical binding]; other site
425104002926	Switch I region; other site
425104002927	G2 box; other site
425104002928	G3 box; other site
425104002929	Switch II region; other site
425104002930	G4 box; other site
425104002931	G5 box; other site
425104002932	Uncharacterized conserved protein [Function unknown]; Region: COG2966
425104002933	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
425104002934	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
425104002935	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
425104002936	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
425104002937	NADP+ binding site [chemical binding]; other site
425104002938	folate binding site [chemical binding]; other site
425104002939	Protein of unknown function (DUF3718); Region: DUF3718; pfam12514
425104002940	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104002941	dimerization interface [polypeptide binding]; other site
425104002942	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104002943	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104002944	dimer interface [polypeptide binding]; other site
425104002945	putative CheW interface [polypeptide binding]; other site
425104002946	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
425104002947	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
425104002948	active site
425104002949	metal binding site [ion binding]; metal-binding site
425104002950	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
425104002951	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
425104002952	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104002953	S-adenosylmethionine binding site [chemical binding]; other site
425104002954	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
425104002955	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
425104002956	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
425104002957	SurA N-terminal domain; Region: SurA_N; pfam09312
425104002958	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
425104002959	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
425104002960	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
425104002961	OstA-like protein; Region: OstA; cl00844
425104002962	Organic solvent tolerance protein; Region: OstA_C; pfam04453
425104002963	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
425104002964	Phosphotransferase enzyme family; Region: APH; pfam01636
425104002965	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
425104002966	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
425104002967	Substrate binding site; other site
425104002968	metal-binding site
425104002969	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
425104002970	putative metal binding site [ion binding]; other site
425104002971	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
425104002972	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
425104002973	HSP70 interaction site [polypeptide binding]; other site
425104002974	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
425104002975	glycerate dehydrogenase; Provisional; Region: PRK06487
425104002976	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
425104002977	putative ligand binding site [chemical binding]; other site
425104002978	putative NAD binding site [chemical binding]; other site
425104002979	catalytic site [active]
425104002980	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
425104002981	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104002982	ATP-grasp domain; Region: ATP-grasp; pfam02222
425104002983	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
425104002984	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
425104002985	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104002986	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104002987	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
425104002988	Sel1-like repeats; Region: SEL1; smart00671
425104002989	Sel1-like repeats; Region: SEL1; smart00671
425104002990	Ycf46; Provisional; Region: ycf46; CHL00195
425104002991	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104002992	Walker A motif; other site
425104002993	ATP binding site [chemical binding]; other site
425104002994	Walker B motif; other site
425104002995	arginine finger; other site
425104002996	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
425104002997	Predicted Fe-S protein [General function prediction only]; Region: COG3313
425104002998	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
425104002999	HAMP domain; Region: HAMP; pfam00672
425104003000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104003001	dimer interface [polypeptide binding]; other site
425104003002	phosphorylation site [posttranslational modification]
425104003003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104003004	ATP binding site [chemical binding]; other site
425104003005	Mg2+ binding site [ion binding]; other site
425104003006	G-X-G motif; other site
425104003007	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
425104003008	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104003009	active site
425104003010	phosphorylation site [posttranslational modification]
425104003011	intermolecular recognition site; other site
425104003012	dimerization interface [polypeptide binding]; other site
425104003013	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104003014	DNA binding site [nucleotide binding]
425104003015	Protein of unknown function (DUF3019); Region: DUF3019; pfam11456
425104003016	MltA-interacting protein MipA; Region: MipA; cl01504
425104003017	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
425104003018	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
425104003019	FAD binding site [chemical binding]; other site
425104003020	substrate binding pocket [chemical binding]; other site
425104003021	catalytic base [active]
425104003022	Response regulator receiver domain; Region: Response_reg; pfam00072
425104003023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104003024	active site
425104003025	phosphorylation site [posttranslational modification]
425104003026	intermolecular recognition site; other site
425104003027	dimerization interface [polypeptide binding]; other site
425104003028	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
425104003029	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104003030	PAS fold; Region: PAS_3; pfam08447
425104003031	putative active site [active]
425104003032	heme pocket [chemical binding]; other site
425104003033	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
425104003034	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104003035	dimer interface [polypeptide binding]; other site
425104003036	phosphorylation site [posttranslational modification]
425104003037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104003038	ATP binding site [chemical binding]; other site
425104003039	Mg2+ binding site [ion binding]; other site
425104003040	G-X-G motif; other site
425104003041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104003042	active site
425104003043	phosphorylation site [posttranslational modification]
425104003044	intermolecular recognition site; other site
425104003045	universal stress protein UspE; Provisional; Region: PRK11175
425104003046	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104003047	Ligand Binding Site [chemical binding]; other site
425104003048	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104003049	Ligand Binding Site [chemical binding]; other site
425104003050	YcxB-like protein; Region: YcxB; pfam14317
425104003051	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104003052	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
425104003053	active site
425104003054	metal binding site [ion binding]; metal-binding site
425104003055	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104003056	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
425104003057	active site
425104003058	metal binding site [ion binding]; metal-binding site
425104003059	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
425104003060	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
425104003061	Predicted transcriptional regulator [Transcription]; Region: COG2345
425104003062	Adenosine deaminase z-alpha domain; Region: z-alpha; cl02659
425104003063	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
425104003064	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
425104003065	RNA binding surface [nucleotide binding]; other site
425104003066	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
425104003067	active site
425104003068	uracil binding [chemical binding]; other site
425104003069	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104003070	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104003071	LysR substrate binding domain; Region: LysR_substrate; pfam03466
425104003072	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
425104003073	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
425104003074	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104003075	Major Facilitator Superfamily; Region: MFS_1; pfam07690
425104003076	putative substrate translocation pore; other site
425104003077	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
425104003078	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104003079	Coenzyme A binding pocket [chemical binding]; other site
425104003080	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104003081	HAMP domain; Region: HAMP; pfam00672
425104003082	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104003083	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104003084	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104003085	dimer interface [polypeptide binding]; other site
425104003086	putative CheW interface [polypeptide binding]; other site
425104003087	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
425104003088	AMMECR1; Region: AMMECR1; pfam01871
425104003089	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
425104003090	putative ligand binding pocket/active site [active]
425104003091	putative metal binding site [ion binding]; other site
425104003092	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
425104003093	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104003094	FeS/SAM binding site; other site
425104003095	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
425104003096	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104003097	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
425104003098	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104003099	dimer interface [polypeptide binding]; other site
425104003100	putative CheW interface [polypeptide binding]; other site
425104003101	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
425104003102	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
425104003103	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
425104003104	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104003105	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104003106	dimer interface [polypeptide binding]; other site
425104003107	putative CheW interface [polypeptide binding]; other site
425104003108	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
425104003109	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
425104003110	HIGH motif; other site
425104003111	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
425104003112	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
425104003113	active site
425104003114	KMSKS motif; other site
425104003115	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
425104003116	tRNA binding surface [nucleotide binding]; other site
425104003117	anticodon binding site; other site
425104003118	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
425104003119	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
425104003120	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
425104003121	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
425104003122	GTPase RsgA; Reviewed; Region: PRK01889
425104003123	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
425104003124	GTPase/Zn-binding domain interface [polypeptide binding]; other site
425104003125	GTP/Mg2+ binding site [chemical binding]; other site
425104003126	G4 box; other site
425104003127	G5 box; other site
425104003128	G1 box; other site
425104003129	Switch I region; other site
425104003130	G2 box; other site
425104003131	G3 box; other site
425104003132	Switch II region; other site
425104003133	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104003134	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104003135	dimer interface [polypeptide binding]; other site
425104003136	putative CheW interface [polypeptide binding]; other site
425104003137	Protein of unknown function, DUF393; Region: DUF393; pfam04134
425104003138	multifunctional aminopeptidase A; Provisional; Region: PRK00913
425104003139	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
425104003140	interface (dimer of trimers) [polypeptide binding]; other site
425104003141	Substrate-binding/catalytic site; other site
425104003142	Zn-binding sites [ion binding]; other site
425104003143	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
425104003144	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
425104003145	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
425104003146	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
425104003147	RDD family; Region: RDD; pfam06271
425104003148	Protein of unknown function (DUF2960); Region: DUF2960; pfam11173
425104003149	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
425104003150	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104003151	Coenzyme A binding pocket [chemical binding]; other site
425104003152	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
425104003153	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
425104003154	active site
425104003155	Zn binding site [ion binding]; other site
425104003156	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
425104003157	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
425104003158	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
425104003159	ATP binding site [chemical binding]; other site
425104003160	Mg++ binding site [ion binding]; other site
425104003161	motif III; other site
425104003162	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104003163	nucleotide binding region [chemical binding]; other site
425104003164	ATP-binding site [chemical binding]; other site
425104003165	Response regulator receiver domain; Region: Response_reg; pfam00072
425104003166	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104003167	active site
425104003168	phosphorylation site [posttranslational modification]
425104003169	intermolecular recognition site; other site
425104003170	dimerization interface [polypeptide binding]; other site
425104003171	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104003172	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
425104003173	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
425104003174	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
425104003175	active site
425104003176	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
425104003177	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
425104003178	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
425104003179	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
425104003180	active site
425104003181	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
425104003182	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
425104003183	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
425104003184	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
425104003185	active site
425104003186	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
425104003187	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
425104003188	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
425104003189	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
425104003190	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104003191	dimer interface [polypeptide binding]; other site
425104003192	phosphorylation site [posttranslational modification]
425104003193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104003194	ATP binding site [chemical binding]; other site
425104003195	Mg2+ binding site [ion binding]; other site
425104003196	G-X-G motif; other site
425104003197	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
425104003198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104003199	active site
425104003200	phosphorylation site [posttranslational modification]
425104003201	intermolecular recognition site; other site
425104003202	dimerization interface [polypeptide binding]; other site
425104003203	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104003204	DNA binding site [nucleotide binding]
425104003205	Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574
425104003206	active site
425104003207	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
425104003208	Predicted integral membrane protein [Function unknown]; Region: COG5615
425104003209	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
425104003210	MarR family; Region: MarR_2; cl17246
425104003211	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
425104003212	CoenzymeA binding site [chemical binding]; other site
425104003213	subunit interaction site [polypeptide binding]; other site
425104003214	PHB binding site; other site
425104003215	Domain of unknown function (DUF368); Region: DUF368; pfam04018
425104003216	Protein of unknown function (DUF3634); Region: DUF3634; pfam12321
425104003217	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
425104003218	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
425104003219	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
425104003220	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
425104003221	tetrameric interface [polypeptide binding]; other site
425104003222	NAD binding site [chemical binding]; other site
425104003223	catalytic residues [active]
425104003224	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
425104003225	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
425104003226	inhibitor-cofactor binding pocket; inhibition site
425104003227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104003228	catalytic residue [active]
425104003229	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
425104003230	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
425104003231	NAD(P) binding site [chemical binding]; other site
425104003232	catalytic residues [active]
425104003233	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
425104003234	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
425104003235	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104003236	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104003237	substrate binding pocket [chemical binding]; other site
425104003238	membrane-bound complex binding site; other site
425104003239	hinge residues; other site
425104003240	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
425104003241	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
425104003242	substrate binding site [chemical binding]; other site
425104003243	dimer interface [polypeptide binding]; other site
425104003244	ATP binding site [chemical binding]; other site
425104003245	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
425104003246	active site
425104003247	tetramer interface [polypeptide binding]; other site
425104003248	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
425104003249	putative active site [active]
425104003250	putative metal binding residues [ion binding]; other site
425104003251	signature motif; other site
425104003252	putative triphosphate binding site [ion binding]; other site
425104003253	dimer interface [polypeptide binding]; other site
425104003254	Uncharacterized conserved protein [Function unknown]; Region: COG3791
425104003255	Uncharacterized conserved protein [Function unknown]; Region: COG3791
425104003256	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
425104003257	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
425104003258	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
425104003259	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
425104003260	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
425104003261	non-specific DNA binding site [nucleotide binding]; other site
425104003262	salt bridge; other site
425104003263	sequence-specific DNA binding site [nucleotide binding]; other site
425104003264	Cupin domain; Region: Cupin_2; pfam07883
425104003265	Peptidase C26; Region: Peptidase_C26; pfam07722
425104003266	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
425104003267	catalytic triad [active]
425104003268	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
425104003269	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
425104003270	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
425104003271	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
425104003272	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
425104003273	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104003274	Walker A/P-loop; other site
425104003275	ATP binding site [chemical binding]; other site
425104003276	Q-loop/lid; other site
425104003277	ABC transporter signature motif; other site
425104003278	Walker B; other site
425104003279	D-loop; other site
425104003280	H-loop/switch region; other site
425104003281	TOBE domain; Region: TOBE_2; pfam08402
425104003282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104003283	dimer interface [polypeptide binding]; other site
425104003284	conserved gate region; other site
425104003285	putative PBP binding loops; other site
425104003286	ABC-ATPase subunit interface; other site
425104003287	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
425104003288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104003289	dimer interface [polypeptide binding]; other site
425104003290	conserved gate region; other site
425104003291	putative PBP binding loops; other site
425104003292	ABC-ATPase subunit interface; other site
425104003293	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
425104003294	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
425104003295	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104003296	dimerization interface [polypeptide binding]; other site
425104003297	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104003298	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104003299	dimer interface [polypeptide binding]; other site
425104003300	putative CheW interface [polypeptide binding]; other site
425104003301	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
425104003302	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
425104003303	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
425104003304	4Fe-4S binding domain; Region: Fer4; pfam00037
425104003305	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
425104003306	4Fe-4S binding domain; Region: Fer4; pfam00037
425104003307	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
425104003308	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
425104003309	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
425104003310	dimer interface [polypeptide binding]; other site
425104003311	PYR/PP interface [polypeptide binding]; other site
425104003312	TPP binding site [chemical binding]; other site
425104003313	substrate binding site [chemical binding]; other site
425104003314	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
425104003315	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
425104003316	TPP-binding site [chemical binding]; other site
425104003317	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
425104003318	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
425104003319	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
425104003320	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
425104003321	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
425104003322	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
425104003323	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
425104003324	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
425104003325	DNA binding residues [nucleotide binding]
425104003326	DNA primase; Validated; Region: dnaG; PRK05667
425104003327	CHC2 zinc finger; Region: zf-CHC2; pfam01807
425104003328	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
425104003329	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
425104003330	active site
425104003331	metal binding site [ion binding]; metal-binding site
425104003332	interdomain interaction site; other site
425104003333	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
425104003334	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
425104003335	Yqey-like protein; Region: YqeY; pfam09424
425104003336	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
425104003337	UGMP family protein; Validated; Region: PRK09604
425104003338	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
425104003339	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
425104003340	Dihydroneopterin aldolase; Region: FolB; smart00905
425104003341	active site
425104003342	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
425104003343	catalytic center binding site [active]
425104003344	ATP binding site [chemical binding]; other site
425104003345	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
425104003346	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
425104003347	Methyltransferase domain; Region: Methyltransf_11; pfam08241
425104003348	L,D-transpeptidase; Provisional; Region: PRK10190
425104003349	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
425104003350	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
425104003351	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
425104003352	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
425104003353	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
425104003354	active site
425104003355	NTP binding site [chemical binding]; other site
425104003356	metal binding triad [ion binding]; metal-binding site
425104003357	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
425104003358	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104003359	Zn2+ binding site [ion binding]; other site
425104003360	Mg2+ binding site [ion binding]; other site
425104003361	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
425104003362	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104003363	Walker A motif; other site
425104003364	ATP binding site [chemical binding]; other site
425104003365	Walker B motif; other site
425104003366	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
425104003367	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
425104003368	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
425104003369	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
425104003370	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
425104003371	inhibitor-cofactor binding pocket; inhibition site
425104003372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104003373	catalytic residue [active]
425104003374	aspartate carbamoyltransferase; Provisional; Region: PRK08192
425104003375	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
425104003376	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
425104003377	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
425104003378	Aspartase; Region: Aspartase; cd01357
425104003379	active sites [active]
425104003380	tetramer interface [polypeptide binding]; other site
425104003381	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
425104003382	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
425104003383	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
425104003384	Cl- selectivity filter; other site
425104003385	Cl- binding residues [ion binding]; other site
425104003386	pore gating glutamate residue; other site
425104003387	dimer interface [polypeptide binding]; other site
425104003388	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
425104003389	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
425104003390	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
425104003391	dimer interface [polypeptide binding]; other site
425104003392	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
425104003393	active site
425104003394	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
425104003395	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104003396	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104003397	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
425104003398	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104003399	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104003400	DNA binding site [nucleotide binding]
425104003401	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
425104003402	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
425104003403	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
425104003404	putative peptidase; Provisional; Region: PRK11649
425104003405	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
425104003406	Peptidase family M23; Region: Peptidase_M23; pfam01551
425104003407	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
425104003408	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
425104003409	active site
425104003410	HIGH motif; other site
425104003411	dimer interface [polypeptide binding]; other site
425104003412	KMSKS motif; other site
425104003413	S4 RNA-binding domain; Region: S4; smart00363
425104003414	RNA binding surface [nucleotide binding]; other site
425104003415	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
425104003416	POT family; Region: PTR2; cl17359
425104003417	Right handed beta helix region; Region: Beta_helix; pfam13229
425104003418	Cytochrome c; Region: Cytochrom_C; pfam00034
425104003419	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
425104003420	Cytochrome c; Region: Cytochrom_C; pfam00034
425104003421	Cytochrome c; Region: Cytochrom_C; pfam00034
425104003422	Helix-turn-helix domain; Region: HTH_18; pfam12833
425104003423	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104003424	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104003425	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
425104003426	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104003427	SnoaL-like domain; Region: SnoaL_2; pfam12680
425104003428	Predicted membrane protein [Function unknown]; Region: COG2860
425104003429	UPF0126 domain; Region: UPF0126; pfam03458
425104003430	UPF0126 domain; Region: UPF0126; pfam03458
425104003431	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
425104003432	Cobalamin biosynthesis protein CobD/CbiB [Coenzyme metabolism]; Region: CbiB; COG1270
425104003433	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
425104003434	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
425104003435	CHASE3 domain; Region: CHASE3; pfam05227
425104003436	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104003437	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104003438	metal binding site [ion binding]; metal-binding site
425104003439	active site
425104003440	I-site; other site
425104003441	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
425104003442	BCCT family transporter; Region: BCCT; cl00569
425104003443	choline dehydrogenase; Validated; Region: PRK02106
425104003444	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
425104003445	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
425104003446	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
425104003447	tetrameric interface [polypeptide binding]; other site
425104003448	NAD binding site [chemical binding]; other site
425104003449	catalytic residues [active]
425104003450	transcriptional regulator BetI; Validated; Region: PRK00767
425104003451	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104003452	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
425104003453	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
425104003454	active site
425104003455	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
425104003456	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
425104003457	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
425104003458	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
425104003459	substrate binding site [chemical binding]; other site
425104003460	dimer interface [polypeptide binding]; other site
425104003461	ATP binding site [chemical binding]; other site
425104003462	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
425104003463	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
425104003464	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
425104003465	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
425104003466	active site
425104003467	dimer interface [polypeptide binding]; other site
425104003468	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
425104003469	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
425104003470	active site
425104003471	FMN binding site [chemical binding]; other site
425104003472	substrate binding site [chemical binding]; other site
425104003473	3Fe-4S cluster binding site [ion binding]; other site
425104003474	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
425104003475	domain interface; other site
425104003476	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
425104003477	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
425104003478	putative binding surface; other site
425104003479	active site
425104003480	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
425104003481	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104003482	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
425104003483	dimerization interface [polypeptide binding]; other site
425104003484	cyclase homology domain; Region: CHD; cd07302
425104003485	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
425104003486	nucleotidyl binding site; other site
425104003487	metal binding site [ion binding]; metal-binding site
425104003488	dimer interface [polypeptide binding]; other site
425104003489	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
425104003490	putative DNA-binding cleft [nucleotide binding]; other site
425104003491	putative DNA clevage site; other site
425104003492	molecular lever; other site
425104003493	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
425104003494	putative active site [active]
425104003495	Ap4A binding site [chemical binding]; other site
425104003496	nudix motif; other site
425104003497	putative metal binding site [ion binding]; other site
425104003498	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
425104003499	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
425104003500	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
425104003501	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
425104003502	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
425104003503	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
425104003504	thymidylate synthase; Reviewed; Region: thyA; PRK01827
425104003505	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
425104003506	dimerization interface [polypeptide binding]; other site
425104003507	active site
425104003508	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
425104003509	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
425104003510	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104003511	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104003512	dimerization interface [polypeptide binding]; other site
425104003513	Uncharacterized conserved protein [Function unknown]; Region: COG2938
425104003514	L-aspartate oxidase; Provisional; Region: PRK09077
425104003515	L-aspartate oxidase; Provisional; Region: PRK06175
425104003516	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
425104003517	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
425104003518	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
425104003519	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
425104003520	DNA binding residues [nucleotide binding]
425104003521	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
425104003522	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
425104003523	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
425104003524	anti-sigma E factor; Provisional; Region: rseB; PRK09455
425104003525	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
425104003526	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
425104003527	GTP-binding protein LepA; Provisional; Region: PRK05433
425104003528	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
425104003529	G1 box; other site
425104003530	putative GEF interaction site [polypeptide binding]; other site
425104003531	GTP/Mg2+ binding site [chemical binding]; other site
425104003532	Switch I region; other site
425104003533	G2 box; other site
425104003534	G3 box; other site
425104003535	Switch II region; other site
425104003536	G4 box; other site
425104003537	G5 box; other site
425104003538	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
425104003539	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
425104003540	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
425104003541	signal peptidase I; Provisional; Region: PRK10861
425104003542	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
425104003543	Catalytic site [active]
425104003544	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
425104003545	ribonuclease III; Reviewed; Region: rnc; PRK00102
425104003546	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
425104003547	dimerization interface [polypeptide binding]; other site
425104003548	active site
425104003549	metal binding site [ion binding]; metal-binding site
425104003550	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
425104003551	dsRNA binding site [nucleotide binding]; other site
425104003552	GTPase Era; Reviewed; Region: era; PRK00089
425104003553	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
425104003554	G1 box; other site
425104003555	GTP/Mg2+ binding site [chemical binding]; other site
425104003556	Switch I region; other site
425104003557	G2 box; other site
425104003558	Switch II region; other site
425104003559	G3 box; other site
425104003560	G4 box; other site
425104003561	G5 box; other site
425104003562	KH domain; Region: KH_2; pfam07650
425104003563	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
425104003564	Recombination protein O N terminal; Region: RecO_N; pfam11967
425104003565	Recombination protein O C terminal; Region: RecO_C; pfam02565
425104003566	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
425104003567	active site
425104003568	hydrophilic channel; other site
425104003569	dimerization interface [polypeptide binding]; other site
425104003570	catalytic residues [active]
425104003571	active site lid [active]
425104003572	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
425104003573	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
425104003574	active site
425104003575	Zn binding site [ion binding]; other site
425104003576	PAS fold; Region: PAS_3; pfam08447
425104003577	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104003578	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104003579	metal binding site [ion binding]; metal-binding site
425104003580	active site
425104003581	I-site; other site
425104003582	Protein of unknown function (DUF962); Region: DUF962; cl01879
425104003583	hypothetical protein; Provisional; Region: PRK11573
425104003584	Domain of unknown function DUF21; Region: DUF21; pfam01595
425104003585	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
425104003586	Transporter associated domain; Region: CorC_HlyC; smart01091
425104003587	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
425104003588	signal recognition particle protein; Provisional; Region: PRK10867
425104003589	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
425104003590	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
425104003591	P loop; other site
425104003592	GTP binding site [chemical binding]; other site
425104003593	Signal peptide binding domain; Region: SRP_SPB; pfam02978
425104003594	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
425104003595	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
425104003596	RimM N-terminal domain; Region: RimM; pfam01782
425104003597	PRC-barrel domain; Region: PRC; pfam05239
425104003598	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
425104003599	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
425104003600	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
425104003601	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
425104003602	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
425104003603	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
425104003604	prephenate dehydrogenase; Validated; Region: PRK08507
425104003605	hybrid cluster protein; Provisional; Region: PRK05290
425104003606	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
425104003607	ACS interaction site; other site
425104003608	CODH interaction site; other site
425104003609	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
425104003610	hybrid metal cluster; other site
425104003611	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
425104003612	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
425104003613	FAD binding pocket [chemical binding]; other site
425104003614	FAD binding motif [chemical binding]; other site
425104003615	phosphate binding motif [ion binding]; other site
425104003616	beta-alpha-beta structure motif; other site
425104003617	NAD binding pocket [chemical binding]; other site
425104003618	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
425104003619	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
425104003620	catalytic loop [active]
425104003621	iron binding site [ion binding]; other site
425104003622	Predicted membrane protein [Function unknown]; Region: COG3671
425104003623	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
425104003624	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
425104003625	Prephenate dehydratase; Region: PDT; pfam00800
425104003626	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
425104003627	putative L-Phe binding site [chemical binding]; other site
425104003628	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
425104003629	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
425104003630	30S subunit binding site; other site
425104003631	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
425104003632	Cytochrome C' Region: Cytochrom_C_2; pfam01322
425104003633	Trp repressor protein; Region: Trp_repressor; cl17266
425104003634	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
425104003635	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
425104003636	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
425104003637	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
425104003638	putative catalytic residues [active]
425104003639	putative nucleotide binding site [chemical binding]; other site
425104003640	putative aspartate binding site [chemical binding]; other site
425104003641	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
425104003642	dimer interface [polypeptide binding]; other site
425104003643	putative threonine allosteric regulatory site; other site
425104003644	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
425104003645	putative threonine allosteric regulatory site; other site
425104003646	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
425104003647	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
425104003648	homoserine kinase; Provisional; Region: PRK01212
425104003649	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
425104003650	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
425104003651	threonine synthase; Validated; Region: PRK09225
425104003652	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
425104003653	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
425104003654	catalytic residue [active]
425104003655	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
425104003656	endonuclease IV; Provisional; Region: PRK01060
425104003657	AP (apurinic/apyrimidinic) site pocket; other site
425104003658	DNA interaction; other site
425104003659	Metal-binding active site; metal-binding site
425104003660	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
425104003661	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104003662	putative active site [active]
425104003663	heme pocket [chemical binding]; other site
425104003664	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104003665	dimer interface [polypeptide binding]; other site
425104003666	phosphorylation site [posttranslational modification]
425104003667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104003668	ATP binding site [chemical binding]; other site
425104003669	Mg2+ binding site [ion binding]; other site
425104003670	G-X-G motif; other site
425104003671	Response regulator receiver domain; Region: Response_reg; pfam00072
425104003672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104003673	active site
425104003674	phosphorylation site [posttranslational modification]
425104003675	intermolecular recognition site; other site
425104003676	dimerization interface [polypeptide binding]; other site
425104003677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104003678	Response regulator receiver domain; Region: Response_reg; pfam00072
425104003679	active site
425104003680	phosphorylation site [posttranslational modification]
425104003681	intermolecular recognition site; other site
425104003682	dimerization interface [polypeptide binding]; other site
425104003683	Hemerythrin-like domain; Region: Hr-like; cd12108
425104003684	Fe binding site [ion binding]; other site
425104003685	Protein of unknown function (DUF3545); Region: DUF3545; pfam12065
425104003686	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
425104003687	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
425104003688	active site
425104003689	dimer interface [polypeptide binding]; other site
425104003690	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
425104003691	dimer interface [polypeptide binding]; other site
425104003692	active site
425104003693	transaldolase-like protein; Provisional; Region: PTZ00411
425104003694	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
425104003695	active site
425104003696	dimer interface [polypeptide binding]; other site
425104003697	catalytic residue [active]
425104003698	putative phosphoketolase; Provisional; Region: PRK05261
425104003699	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
425104003700	TPP-binding site; other site
425104003701	XFP C-terminal domain; Region: XFP_C; pfam09363
425104003702	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
425104003703	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
425104003704	hypothetical protein; Validated; Region: PRK02101
425104003705	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
425104003706	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
425104003707	PA/protease or protease-like domain interface [polypeptide binding]; other site
425104003708	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
425104003709	Peptidase family M28; Region: Peptidase_M28; pfam04389
425104003710	metal binding site [ion binding]; metal-binding site
425104003711	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
425104003712	dimerization interface [polypeptide binding]; other site
425104003713	putative DNA binding site [nucleotide binding]; other site
425104003714	putative Zn2+ binding site [ion binding]; other site
425104003715	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
425104003716	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
425104003717	MviN-like protein; Region: MVIN; pfam03023
425104003718	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
425104003719	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
425104003720	active site
425104003721	Riboflavin kinase; Region: Flavokinase; smart00904
425104003722	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
425104003723	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
425104003724	active site
425104003725	HIGH motif; other site
425104003726	nucleotide binding site [chemical binding]; other site
425104003727	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
425104003728	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
425104003729	active site
425104003730	KMSKS motif; other site
425104003731	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
425104003732	tRNA binding surface [nucleotide binding]; other site
425104003733	anticodon binding site; other site
425104003734	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
425104003735	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
425104003736	lipoprotein signal peptidase; Provisional; Region: PRK14787
425104003737	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
425104003738	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
425104003739	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
425104003740	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
425104003741	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
425104003742	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
425104003743	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
425104003744	PilX N-terminal; Region: PilX_N; pfam14341
425104003745	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
425104003746	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
425104003747	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
425104003748	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
425104003749	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
425104003750	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
425104003751	Type II transport protein GspH; Region: GspH; pfam12019
425104003752	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
425104003753	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
425104003754	Type II transport protein GspH; Region: GspH; pfam12019
425104003755	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
425104003756	Nitrogen regulatory protein P-II; Region: P-II; smart00938
425104003757	Transcriptional regulators [Transcription]; Region: PurR; COG1609
425104003758	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
425104003759	DNA binding site [nucleotide binding]
425104003760	domain linker motif; other site
425104003761	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
425104003762	putative dimerization interface [polypeptide binding]; other site
425104003763	putative ligand binding site [chemical binding]; other site
425104003764	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
425104003765	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104003766	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104003767	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
425104003768	SapC; Region: SapC; pfam07277
425104003769	Putative carbohydrate binding domain; Region: CHB_HEX; smart01081
425104003770	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
425104003771	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
425104003772	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569
425104003773	active site
425104003774	C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847
425104003775	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
425104003776	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
425104003777	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
425104003778	active site
425104003779	dimer interface [polypeptide binding]; other site
425104003780	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
425104003781	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
425104003782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104003783	putative substrate translocation pore; other site
425104003784	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
425104003785	hypothetical protein; Provisional; Region: PRK03757
425104003786	oxidative damage protection protein; Provisional; Region: PRK05408
425104003787	adenine DNA glycosylase; Provisional; Region: PRK10880
425104003788	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
425104003789	minor groove reading motif; other site
425104003790	helix-hairpin-helix signature motif; other site
425104003791	substrate binding pocket [chemical binding]; other site
425104003792	active site
425104003793	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
425104003794	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
425104003795	DNA binding and oxoG recognition site [nucleotide binding]
425104003796	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104003797	S-adenosylmethionine binding site [chemical binding]; other site
425104003798	hypothetical protein; Provisional; Region: PRK11702
425104003799	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
425104003800	glutaminase; Provisional; Region: PRK00971
425104003801	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
425104003802	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104003803	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104003804	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104003805	putative effector binding pocket; other site
425104003806	dimerization interface [polypeptide binding]; other site
425104003807	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
425104003808	HemN family oxidoreductase; Provisional; Region: PRK05660
425104003809	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104003810	FeS/SAM binding site; other site
425104003811	HemN C-terminal domain; Region: HemN_C; pfam06969
425104003812	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
425104003813	active site
425104003814	dimerization interface [polypeptide binding]; other site
425104003815	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
425104003816	hypothetical protein; Validated; Region: PRK05090
425104003817	YGGT family; Region: YGGT; pfam02325
425104003818	YGGT family; Region: YGGT; pfam02325
425104003819	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
425104003820	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
425104003821	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
425104003822	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
425104003823	catalytic residue [active]
425104003824	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
425104003825	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
425104003826	Walker A motif; other site
425104003827	ATP binding site [chemical binding]; other site
425104003828	Walker B motif; other site
425104003829	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
425104003830	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
425104003831	Walker A motif; other site
425104003832	ATP binding site [chemical binding]; other site
425104003833	Walker B motif; other site
425104003834	ferrochelatase; Reviewed; Region: hemH; PRK00035
425104003835	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
425104003836	C-terminal domain interface [polypeptide binding]; other site
425104003837	active site
425104003838	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
425104003839	active site
425104003840	N-terminal domain interface [polypeptide binding]; other site
425104003841	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
425104003842	hypothetical protein; Validated; Region: PRK00228
425104003843	translation initiation factor Sui1; Validated; Region: PRK06824
425104003844	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
425104003845	putative rRNA binding site [nucleotide binding]; other site
425104003846	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
425104003847	Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561
425104003848	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104003849	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104003850	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104003851	dimerization interface [polypeptide binding]; other site
425104003852	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
425104003853	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
425104003854	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
425104003855	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
425104003856	ligand binding site [chemical binding]; other site
425104003857	mechanosensitive channel MscS; Provisional; Region: PRK10334
425104003858	Conserved TM helix; Region: TM_helix; pfam05552
425104003859	Mechanosensitive ion channel; Region: MS_channel; pfam00924
425104003860	Predicted membrane protein [Function unknown]; Region: COG2860
425104003861	UPF0126 domain; Region: UPF0126; pfam03458
425104003862	UPF0126 domain; Region: UPF0126; pfam03458
425104003863	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
425104003864	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
425104003865	tetramer interface [polypeptide binding]; other site
425104003866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104003867	catalytic residue [active]
425104003868	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
425104003869	dimer interface [polypeptide binding]; other site
425104003870	Alkaline phosphatase homologues; Region: alkPPc; smart00098
425104003871	active site
425104003872	Alkaline phosphatase homologues; Region: alkPPc; smart00098
425104003873	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
425104003874	active site
425104003875	dimer interface [polypeptide binding]; other site
425104003876	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
425104003877	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
425104003878	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
425104003879	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104003880	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104003881	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104003882	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104003883	Protein export membrane protein; Region: SecD_SecF; cl14618
425104003884	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
425104003885	DNA-binding site [nucleotide binding]; DNA binding site
425104003886	RNA-binding motif; other site
425104003887	putative alcohol dehydrogenase; Provisional; Region: PRK09860
425104003888	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
425104003889	dimer interface [polypeptide binding]; other site
425104003890	active site
425104003891	metal binding site [ion binding]; metal-binding site
425104003892	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104003893	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
425104003894	putative deacylase active site [active]
425104003895	Uncharacterized conserved protein [Function unknown]; Region: COG1432
425104003896	LabA_like proteins; Region: LabA; cd10911
425104003897	putative metal binding site [ion binding]; other site
425104003898	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104003899	binding surface
425104003900	TPR motif; other site
425104003901	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104003902	binding surface
425104003903	TPR motif; other site
425104003904	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
425104003905	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
425104003906	SEC-C motif; Region: SEC-C; pfam02810
425104003907	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
425104003908	SEC-C motif; Region: SEC-C; pfam02810
425104003909	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
425104003910	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104003911	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104003912	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104003913	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104003914	Protein of unknown function (DUF419); Region: DUF419; pfam04237
425104003915	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
425104003916	Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425
425104003917	active site
425104003918	metal binding site [ion binding]; metal-binding site
425104003919	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
425104003920	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104003921	Walker A/P-loop; other site
425104003922	ATP binding site [chemical binding]; other site
425104003923	Q-loop/lid; other site
425104003924	ABC transporter signature motif; other site
425104003925	Walker B; other site
425104003926	D-loop; other site
425104003927	H-loop/switch region; other site
425104003928	ABC transporter; Region: ABC_tran_2; pfam12848
425104003929	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104003930	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
425104003931	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
425104003932	dimer interface [polypeptide binding]; other site
425104003933	active site
425104003934	glycine-pyridoxal phosphate binding site [chemical binding]; other site
425104003935	folate binding site [chemical binding]; other site
425104003936	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
425104003937	ATP cone domain; Region: ATP-cone; pfam03477
425104003938	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
425104003939	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
425104003940	catalytic motif [active]
425104003941	Zn binding site [ion binding]; other site
425104003942	RibD C-terminal domain; Region: RibD_C; cl17279
425104003943	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
425104003944	Lumazine binding domain; Region: Lum_binding; pfam00677
425104003945	Lumazine binding domain; Region: Lum_binding; pfam00677
425104003946	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
425104003947	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
425104003948	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
425104003949	dimerization interface [polypeptide binding]; other site
425104003950	active site
425104003951	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
425104003952	homopentamer interface [polypeptide binding]; other site
425104003953	active site
425104003954	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
425104003955	putative RNA binding site [nucleotide binding]; other site
425104003956	thiamine monophosphate kinase; Provisional; Region: PRK05731
425104003957	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
425104003958	ATP binding site [chemical binding]; other site
425104003959	dimerization interface [polypeptide binding]; other site
425104003960	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
425104003961	tetramer interfaces [polypeptide binding]; other site
425104003962	binuclear metal-binding site [ion binding]; other site
425104003963	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
425104003964	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104003965	S-adenosylmethionine binding site [chemical binding]; other site
425104003966	Ets-domain; Region: Ets; cl02599
425104003967	recombination and repair protein; Provisional; Region: PRK10869
425104003968	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
425104003969	Walker A/P-loop; other site
425104003970	ATP binding site [chemical binding]; other site
425104003971	Q-loop/lid; other site
425104003972	The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397
425104003973	coregulator recognition site; other site
425104003974	ligand binding site [chemical binding]; other site
425104003975	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
425104003976	ABC transporter signature motif; other site
425104003977	Walker B; other site
425104003978	D-loop; other site
425104003979	H-loop/switch region; other site
425104003980	Predicted permeases [General function prediction only]; Region: COG0679
425104003981	Protein of unknown function (DUF3319); Region: DUF3319; pfam11782
425104003982	Protein of unknown function (DUF416); Region: DUF416; pfam04222
425104003983	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
425104003984	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
425104003985	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104003986	dimerization interface [polypeptide binding]; other site
425104003987	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104003988	dimer interface [polypeptide binding]; other site
425104003989	phosphorylation site [posttranslational modification]
425104003990	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104003991	ATP binding site [chemical binding]; other site
425104003992	Mg2+ binding site [ion binding]; other site
425104003993	G-X-G motif; other site
425104003994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104003995	active site
425104003996	phosphorylation site [posttranslational modification]
425104003997	intermolecular recognition site; other site
425104003998	dimerization interface [polypeptide binding]; other site
425104003999	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
425104004000	putative binding surface; other site
425104004001	active site
425104004002	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
425104004003	TRAM domain; Region: TRAM; pfam01938
425104004004	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104004005	S-adenosylmethionine binding site [chemical binding]; other site
425104004006	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
425104004007	HD domain; Region: HD_4; pfam13328
425104004008	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
425104004009	synthetase active site [active]
425104004010	NTP binding site [chemical binding]; other site
425104004011	metal binding site [ion binding]; metal-binding site
425104004012	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
425104004013	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
425104004014	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
425104004015	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
425104004016	homodimer interface [polypeptide binding]; other site
425104004017	metal binding site [ion binding]; metal-binding site
425104004018	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
425104004019	homodimer interface [polypeptide binding]; other site
425104004020	active site
425104004021	putative chemical substrate binding site [chemical binding]; other site
425104004022	metal binding site [ion binding]; metal-binding site
425104004023	CTP synthetase; Validated; Region: pyrG; PRK05380
425104004024	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
425104004025	Catalytic site [active]
425104004026	active site
425104004027	UTP binding site [chemical binding]; other site
425104004028	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
425104004029	active site
425104004030	putative oxyanion hole; other site
425104004031	catalytic triad [active]
425104004032	enolase; Provisional; Region: eno; PRK00077
425104004033	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
425104004034	dimer interface [polypeptide binding]; other site
425104004035	metal binding site [ion binding]; metal-binding site
425104004036	substrate binding pocket [chemical binding]; other site
425104004037	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
425104004038	Septum formation initiator; Region: DivIC; cl17659
425104004039	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
425104004040	substrate binding site; other site
425104004041	dimer interface; other site
425104004042	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
425104004043	homotrimer interaction site [polypeptide binding]; other site
425104004044	zinc binding site [ion binding]; other site
425104004045	CDP-binding sites; other site
425104004046	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
425104004047	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
425104004048	Permutation of conserved domain; other site
425104004049	active site
425104004050	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
425104004051	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
425104004052	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
425104004053	Methyltransferase domain; Region: Methyltransf_18; pfam12847
425104004054	S-adenosylmethionine binding site [chemical binding]; other site
425104004055	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
425104004056	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
425104004057	Peptidase family M23; Region: Peptidase_M23; pfam01551
425104004058	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
425104004059	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
425104004060	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
425104004061	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
425104004062	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
425104004063	DNA binding residues [nucleotide binding]
425104004064	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
425104004065	MutS domain I; Region: MutS_I; pfam01624
425104004066	MutS domain II; Region: MutS_II; pfam05188
425104004067	MutS domain III; Region: MutS_III; pfam05192
425104004068	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
425104004069	Walker A/P-loop; other site
425104004070	ATP binding site [chemical binding]; other site
425104004071	Q-loop/lid; other site
425104004072	ABC transporter signature motif; other site
425104004073	Walker B; other site
425104004074	D-loop; other site
425104004075	H-loop/switch region; other site
425104004076	recombinase A; Provisional; Region: recA; PRK09354
425104004077	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
425104004078	hexamer interface [polypeptide binding]; other site
425104004079	Walker A motif; other site
425104004080	ATP binding site [chemical binding]; other site
425104004081	Walker B motif; other site
425104004082	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
425104004083	Transposase; Region: DEDD_Tnp_IS110; pfam01548
425104004084	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
425104004085	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
425104004086	NIPSNAP; Region: NIPSNAP; pfam07978
425104004087	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104004088	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104004089	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104004090	Protein of unknown function (DUF3374); Region: DUF3374; pfam11854
425104004091	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
425104004092	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
425104004093	molybdopterin cofactor binding site; other site
425104004094	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
425104004095	molybdopterin cofactor binding site; other site
425104004096	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
425104004097	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
425104004098	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
425104004099	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
425104004100	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
425104004101	minor groove reading motif; other site
425104004102	helix-hairpin-helix signature motif; other site
425104004103	substrate binding pocket [chemical binding]; other site
425104004104	active site
425104004105	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104004106	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104004107	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104004108	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104004109	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104004110	dimerization interface [polypeptide binding]; other site
425104004111	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
425104004112	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
425104004113	ADP-ribose binding site [chemical binding]; other site
425104004114	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
425104004115	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
425104004116	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
425104004117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104004118	transcriptional regulator; Provisional; Region: PRK10632
425104004119	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104004120	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104004121	putative effector binding pocket; other site
425104004122	dimerization interface [polypeptide binding]; other site
425104004123	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
425104004124	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
425104004125	motif 1; other site
425104004126	active site
425104004127	motif 2; other site
425104004128	motif 3; other site
425104004129	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
425104004130	DHHA1 domain; Region: DHHA1; pfam02272
425104004131	carbon storage regulator; Provisional; Region: PRK01712
425104004132	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
425104004133	oxaloacetate decarboxylase; Provisional; Region: PRK14040
425104004134	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
425104004135	active site
425104004136	catalytic residues [active]
425104004137	metal binding site [ion binding]; metal-binding site
425104004138	homodimer binding site [polypeptide binding]; other site
425104004139	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
425104004140	carboxyltransferase (CT) interaction site; other site
425104004141	biotinylation site [posttranslational modification]; other site
425104004142	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
425104004143	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
425104004144	SEC-C motif; Region: SEC-C; pfam02810
425104004145	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
425104004146	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
425104004147	Predicted membrane protein [Function unknown]; Region: COG1238
425104004148	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
425104004149	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
425104004150	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
425104004151	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
425104004152	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
425104004153	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
425104004154	glutamate--cysteine ligase; Provisional; Region: PRK02107
425104004155	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
425104004156	N-acetyl-D-glucosamine binding site [chemical binding]; other site
425104004157	catalytic residue [active]
425104004158	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
425104004159	GAF domain; Region: GAF; pfam01590
425104004160	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104004161	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104004162	metal binding site [ion binding]; metal-binding site
425104004163	active site
425104004164	I-site; other site
425104004165	AIR carboxylase; Region: AIRC; pfam00731
425104004166	putative transporter; Provisional; Region: PRK11660
425104004167	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
425104004168	Sulfate transporter family; Region: Sulfate_transp; pfam00916
425104004169	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
425104004170	RNA polymerase sigma factor; Provisional; Region: PRK12513
425104004171	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
425104004172	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
425104004173	DNA binding residues [nucleotide binding]
425104004174	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
425104004175	A new structural DNA glycosylase; Region: AlkD_like; cd06561
425104004176	active site
425104004177	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
425104004178	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
425104004179	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
425104004180	structural tetrad; other site
425104004181	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
425104004182	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
425104004183	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
425104004184	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
425104004185	protein binding site [polypeptide binding]; other site
425104004186	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
425104004187	Domain interface; other site
425104004188	Peptide binding site; other site
425104004189	Active site tetrad [active]
425104004190	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
425104004191	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
425104004192	Protein of unknown function (DUF3649); Region: DUF3649; pfam12365
425104004193	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
425104004194	30S subunit binding site; other site
425104004195	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
425104004196	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
425104004197	TrkA-N domain; Region: TrkA_N; pfam02254
425104004198	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
425104004199	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
425104004200	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
425104004201	PhnA protein; Region: PhnA; pfam03831
425104004202	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
425104004203	putative kinase; Provisional; Region: PRK09954
425104004204	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
425104004205	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
425104004206	substrate binding site [chemical binding]; other site
425104004207	ATP binding site [chemical binding]; other site
425104004208	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
425104004209	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
425104004210	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
425104004211	Hemerythrin; Region: Hemerythrin; cd12107
425104004212	Fe binding site [ion binding]; other site
425104004213	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104004214	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104004215	metal binding site [ion binding]; metal-binding site
425104004216	active site
425104004217	I-site; other site
425104004218	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
425104004219	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686
425104004220	nudix motif; other site
425104004221	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
425104004222	Family of unknown function (DUF633); Region: DUF633; pfam04816
425104004223	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104004224	hypothetical protein; Provisional; Region: PRK11038
425104004225	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
425104004226	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
425104004227	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
425104004228	classical (c) SDRs; Region: SDR_c; cd05233
425104004229	NAD(P) binding site [chemical binding]; other site
425104004230	active site
425104004231	Predicted transcriptional regulators [Transcription]; Region: COG1733
425104004232	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
425104004233	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
425104004234	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104004235	putative active site [active]
425104004236	PAS fold; Region: PAS_3; pfam08447
425104004237	heme pocket [chemical binding]; other site
425104004238	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104004239	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104004240	metal binding site [ion binding]; metal-binding site
425104004241	active site
425104004242	I-site; other site
425104004243	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
425104004244	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
425104004245	Beta-lactamase; Region: Beta-lactamase; pfam00144
425104004246	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104004247	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104004248	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104004249	LrgA family; Region: LrgA; cl00608
425104004250	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
425104004251	Beta-lactamase; Region: Beta-lactamase; pfam00144
425104004252	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
425104004253	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
425104004254	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
425104004255	Domain of unknown function (DUF333); Region: DUF333; pfam03891
425104004256	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104004257	dimerization interface [polypeptide binding]; other site
425104004258	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104004259	PAS domain; Region: PAS_9; pfam13426
425104004260	putative active site [active]
425104004261	heme pocket [chemical binding]; other site
425104004262	PAS domain; Region: PAS; smart00091
425104004263	PAS domain S-box; Region: sensory_box; TIGR00229
425104004264	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104004265	dimer interface [polypeptide binding]; other site
425104004266	phosphorylation site [posttranslational modification]
425104004267	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104004268	ATP binding site [chemical binding]; other site
425104004269	Mg2+ binding site [ion binding]; other site
425104004270	G-X-G motif; other site
425104004271	Response regulator receiver domain; Region: Response_reg; pfam00072
425104004272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104004273	active site
425104004274	phosphorylation site [posttranslational modification]
425104004275	intermolecular recognition site; other site
425104004276	dimerization interface [polypeptide binding]; other site
425104004277	Response regulator receiver domain; Region: Response_reg; pfam00072
425104004278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104004279	active site
425104004280	phosphorylation site [posttranslational modification]
425104004281	intermolecular recognition site; other site
425104004282	dimerization interface [polypeptide binding]; other site
425104004283	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
425104004284	putative binding surface; other site
425104004285	active site
425104004286	Response regulator receiver domain; Region: Response_reg; pfam00072
425104004287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104004288	active site
425104004289	phosphorylation site [posttranslational modification]
425104004290	intermolecular recognition site; other site
425104004291	dimerization interface [polypeptide binding]; other site
425104004292	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104004293	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104004294	metal binding site [ion binding]; metal-binding site
425104004295	active site
425104004296	I-site; other site
425104004297	Response regulator receiver domain; Region: Response_reg; pfam00072
425104004298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104004299	active site
425104004300	phosphorylation site [posttranslational modification]
425104004301	intermolecular recognition site; other site
425104004302	dimerization interface [polypeptide binding]; other site
425104004303	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
425104004304	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
425104004305	NnrU protein; Region: NnrU; pfam07298
425104004306	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
425104004307	universal stress protein UspE; Provisional; Region: PRK11175
425104004308	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104004309	Ligand Binding Site [chemical binding]; other site
425104004310	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104004311	Ligand Binding Site [chemical binding]; other site
425104004312	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
425104004313	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
425104004314	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
425104004315	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
425104004316	Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006
425104004317	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
425104004318	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
425104004319	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
425104004320	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
425104004321	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
425104004322	Helix-turn-helix domain; Region: HTH_18; pfam12833
425104004323	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104004324	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104004325	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104004326	Protein of unknown function (DUF3374); Region: DUF3374; pfam11854
425104004327	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
425104004328	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
425104004329	molybdopterin cofactor binding site; other site
425104004330	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
425104004331	molybdopterin cofactor binding site; other site
425104004332	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
425104004333	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
425104004334	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
425104004335	SmpB-tmRNA interface; other site
425104004336	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
425104004337	putative coenzyme Q binding site [chemical binding]; other site
425104004338	hypothetical protein; Validated; Region: PRK01777
425104004339	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
425104004340	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
425104004341	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
425104004342	active site
425104004343	SAM binding site [chemical binding]; other site
425104004344	homodimer interface [polypeptide binding]; other site
425104004345	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
425104004346	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104004347	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104004348	metal binding site [ion binding]; metal-binding site
425104004349	active site
425104004350	I-site; other site
425104004351	malate synthase A; Region: malate_syn_A; TIGR01344
425104004352	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
425104004353	active site
425104004354	isocitrate lyase; Provisional; Region: PRK15063
425104004355	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
425104004356	tetramer interface [polypeptide binding]; other site
425104004357	active site
425104004358	Mg2+/Mn2+ binding site [ion binding]; other site
425104004359	HDOD domain; Region: HDOD; pfam08668
425104004360	GAF domain; Region: GAF_3; pfam13492
425104004361	SnoaL-like domain; Region: SnoaL_3; pfam13474
425104004362	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
425104004363	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
425104004364	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104004365	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104004366	metal binding site [ion binding]; metal-binding site
425104004367	active site
425104004368	I-site; other site
425104004369	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
425104004370	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
425104004371	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
425104004372	ParA-like protein; Provisional; Region: PHA02518
425104004373	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
425104004374	P-loop; other site
425104004375	Magnesium ion binding site [ion binding]; other site
425104004376	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
425104004377	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
425104004378	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104004379	Coenzyme A binding pocket [chemical binding]; other site
425104004380	Predicted membrane protein [Function unknown]; Region: COG2259
425104004381	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
425104004382	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
425104004383	active site
425104004384	metal binding site [ion binding]; metal-binding site
425104004385	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
425104004386	Domain of unknown function DUF21; Region: DUF21; pfam01595
425104004387	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
425104004388	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
425104004389	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104004390	FeS/SAM binding site; other site
425104004391	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
425104004392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104004393	TPR motif; other site
425104004394	binding surface
425104004395	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
425104004396	Helix-turn-helix domain; Region: HTH_25; pfam13413
425104004397	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
425104004398	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
425104004399	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
425104004400	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
425104004401	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
425104004402	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
425104004403	dimer interface [polypeptide binding]; other site
425104004404	motif 1; other site
425104004405	active site
425104004406	motif 2; other site
425104004407	motif 3; other site
425104004408	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
425104004409	anticodon binding site; other site
425104004410	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
425104004411	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
425104004412	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
425104004413	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
425104004414	Trp docking motif [polypeptide binding]; other site
425104004415	active site
425104004416	GTP-binding protein Der; Reviewed; Region: PRK00093
425104004417	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
425104004418	G1 box; other site
425104004419	GTP/Mg2+ binding site [chemical binding]; other site
425104004420	Switch I region; other site
425104004421	G2 box; other site
425104004422	Switch II region; other site
425104004423	G3 box; other site
425104004424	G4 box; other site
425104004425	G5 box; other site
425104004426	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
425104004427	G1 box; other site
425104004428	GTP/Mg2+ binding site [chemical binding]; other site
425104004429	Switch I region; other site
425104004430	G2 box; other site
425104004431	G3 box; other site
425104004432	Switch II region; other site
425104004433	G4 box; other site
425104004434	G5 box; other site
425104004435	Helix-Turn-Helix DNA binding domain of the Cfa transcription regulator; Region: HTH_Cfa; cd04789
425104004436	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
425104004437	DNA binding residues [nucleotide binding]
425104004438	putative dimer interface [polypeptide binding]; other site
425104004439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104004440	S-adenosylmethionine binding site [chemical binding]; other site
425104004441	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
425104004442	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
425104004443	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
425104004444	putative active site [active]
425104004445	putative NTP binding site [chemical binding]; other site
425104004446	putative nucleic acid binding site [nucleotide binding]; other site
425104004447	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
425104004448	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
425104004449	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
425104004450	trimer interface [polypeptide binding]; other site
425104004451	active site
425104004452	substrate binding site [chemical binding]; other site
425104004453	CoA binding site [chemical binding]; other site
425104004454	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
425104004455	homodimer interaction site [polypeptide binding]; other site
425104004456	cofactor binding site; other site
425104004457	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
425104004458	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
425104004459	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
425104004460	active site
425104004461	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
425104004462	active site
425104004463	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
425104004464	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
425104004465	active site
425104004466	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
425104004467	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
425104004468	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
425104004469	Ligand binding site [chemical binding]; other site
425104004470	Electron transfer flavoprotein domain; Region: ETF; pfam01012
425104004471	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
425104004472	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
425104004473	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
425104004474	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
425104004475	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
425104004476	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
425104004477	active site
425104004478	Zn binding site [ion binding]; other site
425104004479	thymidine kinase; Provisional; Region: PRK04296
425104004480	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
425104004481	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
425104004482	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
425104004483	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
425104004484	active site
425104004485	catalytic residues [active]
425104004486	metal binding site [ion binding]; metal-binding site
425104004487	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
425104004488	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
425104004489	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
425104004490	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
425104004491	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
425104004492	carboxyltransferase (CT) interaction site; other site
425104004493	biotinylation site [posttranslational modification]; other site
425104004494	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
425104004495	gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674
425104004496	substrate binding site [chemical binding]; other site
425104004497	oxyanion hole (OAH) forming residues; other site
425104004498	trimer interface [polypeptide binding]; other site
425104004499	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
425104004500	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
425104004501	isovaleryl-CoA dehydrogenase; Region: PLN02519
425104004502	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
425104004503	substrate binding site [chemical binding]; other site
425104004504	FAD binding site [chemical binding]; other site
425104004505	catalytic base [active]
425104004506	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
425104004507	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
425104004508	DNA binding residues [nucleotide binding]
425104004509	putative dimer interface [polypeptide binding]; other site
425104004510	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
425104004511	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
425104004512	acyl-activating enzyme (AAE) consensus motif; other site
425104004513	AMP binding site [chemical binding]; other site
425104004514	active site
425104004515	CoA binding site [chemical binding]; other site
425104004516	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
425104004517	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
425104004518	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
425104004519	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104004520	Zn2+ binding site [ion binding]; other site
425104004521	Mg2+ binding site [ion binding]; other site
425104004522	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
425104004523	UbiA prenyltransferase family; Region: UbiA; pfam01040
425104004524	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
425104004525	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104004526	NAD(P) binding site [chemical binding]; other site
425104004527	active site
425104004528	acyl-CoA thioesterase II; Provisional; Region: PRK10526
425104004529	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
425104004530	active site
425104004531	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
425104004532	catalytic triad [active]
425104004533	dimer interface [polypeptide binding]; other site
425104004534	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
425104004535	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
425104004536	outer membrane protein W; Provisional; Region: PRK10959
425104004537	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
425104004538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104004539	NAD(P) binding site [chemical binding]; other site
425104004540	active site
425104004541	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
425104004542	homoserine O-succinyltransferase; Provisional; Region: PRK05368
425104004543	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
425104004544	proposed active site lysine [active]
425104004545	conserved cys residue [active]
425104004546	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
425104004547	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
425104004548	dimer interface [polypeptide binding]; other site
425104004549	active site
425104004550	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
425104004551	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
425104004552	tetrameric interface [polypeptide binding]; other site
425104004553	NAD binding site [chemical binding]; other site
425104004554	catalytic residues [active]
425104004555	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
425104004556	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
425104004557	active site
425104004558	enoyl-CoA hydratase; Provisional; Region: PRK09076
425104004559	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
425104004560	substrate binding site [chemical binding]; other site
425104004561	oxyanion hole (OAH) forming residues; other site
425104004562	trimer interface [polypeptide binding]; other site
425104004563	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
425104004564	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
425104004565	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
425104004566	substrate binding site [chemical binding]; other site
425104004567	oxyanion hole (OAH) forming residues; other site
425104004568	trimer interface [polypeptide binding]; other site
425104004569	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
425104004570	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
425104004571	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
425104004572	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
425104004573	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104004574	NAD(P) binding site [chemical binding]; other site
425104004575	active site
425104004576	B12 binding domain; Region: B12-binding; pfam02310
425104004577	B12 binding site [chemical binding]; other site
425104004578	Radical SAM superfamily; Region: Radical_SAM; pfam04055
425104004579	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
425104004580	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104004581	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
425104004582	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
425104004583	DNA binding residues [nucleotide binding]
425104004584	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
425104004585	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
425104004586	metal-binding site [ion binding]
425104004587	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
425104004588	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104004589	motif II; other site
425104004590	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
425104004591	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104004592	Walker A/P-loop; other site
425104004593	ATP binding site [chemical binding]; other site
425104004594	Q-loop/lid; other site
425104004595	ABC transporter signature motif; other site
425104004596	Walker B; other site
425104004597	D-loop; other site
425104004598	H-loop/switch region; other site
425104004599	ABC transporter; Region: ABC_tran_2; pfam12848
425104004600	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104004601	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
425104004602	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
425104004603	Nucleoside recognition; Region: Gate; pfam07670
425104004604	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
425104004605	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
425104004606	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
425104004607	interface (dimer of trimers) [polypeptide binding]; other site
425104004608	Substrate-binding/catalytic site; other site
425104004609	Zn-binding sites [ion binding]; other site
425104004610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104004611	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
425104004612	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
425104004613	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
425104004614	active site
425104004615	RNA/DNA hybrid binding site [nucleotide binding]; other site
425104004616	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
425104004617	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
425104004618	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
425104004619	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
425104004620	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104004621	N-terminal plug; other site
425104004622	ligand-binding site [chemical binding]; other site
425104004623	PEGA domain; Region: PEGA; pfam08308
425104004624	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104004625	HAMP domain; Region: HAMP; pfam00672
425104004626	dimerization interface [polypeptide binding]; other site
425104004627	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104004628	dimer interface [polypeptide binding]; other site
425104004629	putative CheW interface [polypeptide binding]; other site
425104004630	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
425104004631	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
425104004632	ACT domain; Region: ACT_6; pfam13740
425104004633	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
425104004634	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
425104004635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104004636	conserved gate region; other site
425104004637	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104004638	ABC-ATPase subunit interface; other site
425104004639	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
425104004640	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
425104004641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104004642	dimer interface [polypeptide binding]; other site
425104004643	conserved gate region; other site
425104004644	putative PBP binding loops; other site
425104004645	ABC-ATPase subunit interface; other site
425104004646	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
425104004647	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
425104004648	Walker A/P-loop; other site
425104004649	ATP binding site [chemical binding]; other site
425104004650	Q-loop/lid; other site
425104004651	ABC transporter signature motif; other site
425104004652	Walker B; other site
425104004653	D-loop; other site
425104004654	H-loop/switch region; other site
425104004655	transcriptional regulator PhoU; Provisional; Region: PRK11115
425104004656	PhoU domain; Region: PhoU; pfam01895
425104004657	PhoU domain; Region: PhoU; pfam01895
425104004658	BCCT family transporter; Region: BCCT; pfam02028
425104004659	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
425104004660	active site
425104004661	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
425104004662	Methyltransferase domain; Region: Methyltransf_32; pfam13679
425104004663	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
425104004664	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
425104004665	dimer interface [polypeptide binding]; other site
425104004666	active site
425104004667	CoA binding pocket [chemical binding]; other site
425104004668	haloalkane dehalogenase; Provisional; Region: PRK03592
425104004669	peptide synthase; Provisional; Region: PRK09274
425104004670	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910
425104004671	acyl-activating enzyme (AAE) consensus motif; other site
425104004672	putative AMP binding site [chemical binding]; other site
425104004673	putative active site [active]
425104004674	putative CoA binding site [chemical binding]; other site
425104004675	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104004676	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
425104004677	NAD(P) binding site [chemical binding]; other site
425104004678	active site
425104004679	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
425104004680	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
425104004681	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
425104004682	active site
425104004683	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
425104004684	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
425104004685	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
425104004686	active site
425104004687	substrate binding site [chemical binding]; other site
425104004688	metal binding site [ion binding]; metal-binding site
425104004689	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
425104004690	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
425104004691	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
425104004692	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104004693	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104004694	metal binding site [ion binding]; metal-binding site
425104004695	active site
425104004696	I-site; other site
425104004697	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
425104004698	ligand binding site [chemical binding]; other site
425104004699	active site
425104004700	Protein of unknown function (DUF3374); Region: DUF3374; pfam11854
425104004701	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104004702	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104004703	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104004704	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
425104004705	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
425104004706	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
425104004707	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
425104004708	heme-binding residues [chemical binding]; other site
425104004709	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
425104004710	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
425104004711	heme-binding residues [chemical binding]; other site
425104004712	Protein of unknown function (DUF3374); Region: DUF3374; pfam11854
425104004713	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104004714	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104004715	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104004716	FeoA domain; Region: FeoA; pfam04023
425104004717	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
425104004718	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
425104004719	G1 box; other site
425104004720	GTP/Mg2+ binding site [chemical binding]; other site
425104004721	Switch I region; other site
425104004722	G2 box; other site
425104004723	G3 box; other site
425104004724	Switch II region; other site
425104004725	G4 box; other site
425104004726	G5 box; other site
425104004727	Nucleoside recognition; Region: Gate; pfam07670
425104004728	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
425104004729	Nucleoside recognition; Region: Gate; pfam07670
425104004730	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
425104004731	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
425104004732	active site
425104004733	HIGH motif; other site
425104004734	nucleotide binding site [chemical binding]; other site
425104004735	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
425104004736	KMSKS motif; other site
425104004737	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
425104004738	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
425104004739	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
425104004740	active site
425104004741	dinuclear metal binding site [ion binding]; other site
425104004742	dimerization interface [polypeptide binding]; other site
425104004743	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
425104004744	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
425104004745	putative active site [active]
425104004746	putative metal binding site [ion binding]; other site
425104004747	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
425104004748	substrate binding site [chemical binding]; other site
425104004749	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
425104004750	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
425104004751	active site
425104004752	HIGH motif; other site
425104004753	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
425104004754	KMSKS motif; other site
425104004755	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
425104004756	tRNA binding surface [nucleotide binding]; other site
425104004757	anticodon binding site; other site
425104004758	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
425104004759	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
425104004760	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
425104004761	homodimer interface [polypeptide binding]; other site
425104004762	NADP binding site [chemical binding]; other site
425104004763	substrate binding site [chemical binding]; other site
425104004764	trigger factor; Provisional; Region: tig; PRK01490
425104004765	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
425104004766	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
425104004767	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
425104004768	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
425104004769	oligomer interface [polypeptide binding]; other site
425104004770	active site residues [active]
425104004771	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
425104004772	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
425104004773	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104004774	Walker A motif; other site
425104004775	ATP binding site [chemical binding]; other site
425104004776	Walker B motif; other site
425104004777	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
425104004778	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
425104004779	Found in ATP-dependent protease La (LON); Region: LON; smart00464
425104004780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104004781	Walker A motif; other site
425104004782	ATP binding site [chemical binding]; other site
425104004783	Walker B motif; other site
425104004784	arginine finger; other site
425104004785	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
425104004786	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
425104004787	IHF dimer interface [polypeptide binding]; other site
425104004788	IHF - DNA interface [nucleotide binding]; other site
425104004789	periplasmic folding chaperone; Provisional; Region: PRK10788
425104004790	SurA N-terminal domain; Region: SurA_N_3; cl07813
425104004791	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
425104004792	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
425104004793	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
425104004794	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
425104004795	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
425104004796	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
425104004797	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
425104004798	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
425104004799	Walker A/P-loop; other site
425104004800	ATP binding site [chemical binding]; other site
425104004801	Q-loop/lid; other site
425104004802	ABC transporter signature motif; other site
425104004803	Walker B; other site
425104004804	D-loop; other site
425104004805	H-loop/switch region; other site
425104004806	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
425104004807	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
425104004808	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
425104004809	Walker A/P-loop; other site
425104004810	ATP binding site [chemical binding]; other site
425104004811	Q-loop/lid; other site
425104004812	ABC transporter signature motif; other site
425104004813	Walker B; other site
425104004814	D-loop; other site
425104004815	H-loop/switch region; other site
425104004816	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
425104004817	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
425104004818	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
425104004819	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104004820	dimer interface [polypeptide binding]; other site
425104004821	conserved gate region; other site
425104004822	putative PBP binding loops; other site
425104004823	ABC-ATPase subunit interface; other site
425104004824	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
425104004825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104004826	dimer interface [polypeptide binding]; other site
425104004827	conserved gate region; other site
425104004828	putative PBP binding loops; other site
425104004829	ABC-ATPase subunit interface; other site
425104004830	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
425104004831	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
425104004832	peptide binding site [polypeptide binding]; other site
425104004833	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
425104004834	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104004835	Walker A motif; other site
425104004836	ATP binding site [chemical binding]; other site
425104004837	Walker B motif; other site
425104004838	arginine finger; other site
425104004839	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104004840	phage shock protein A; Region: phageshock_pspA; TIGR02977
425104004841	phage shock protein B; Provisional; Region: pspB; PRK09458
425104004842	PspC domain; Region: PspC; cl00864
425104004843	phage shock protein C; Region: phageshock_pspC; TIGR02978
425104004844	YcjX-like family, DUF463; Region: DUF463; pfam04317
425104004845	hypothetical protein; Provisional; Region: PRK05415
425104004846	Domain of unknown function (DUF697); Region: DUF697; cl12064
425104004847	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
425104004848	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
425104004849	homodimer interface [polypeptide binding]; other site
425104004850	substrate-cofactor binding pocket; other site
425104004851	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104004852	catalytic residue [active]
425104004853	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
425104004854	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
425104004855	transmembrane helices; other site
425104004856	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
425104004857	Helix-hairpin-helix motif; Region: HHH; pfam00633
425104004858	Late competence development protein ComFB; Region: ComFB; pfam10719
425104004859	hypothetical protein; Provisional; Region: PRK03641
425104004860	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
425104004861	Primosomal replication protein priB and priC; Region: priB_priC; cl11483
425104004862	hypothetical protein; Provisional; Region: PRK10621
425104004863	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
425104004864	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
425104004865	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
425104004866	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
425104004867	DNA polymerase II; Reviewed; Region: PRK05762
425104004868	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
425104004869	active site
425104004870	catalytic site [active]
425104004871	substrate binding site [chemical binding]; other site
425104004872	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
425104004873	active site
425104004874	metal-binding site
425104004875	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
425104004876	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
425104004877	trimer interface [polypeptide binding]; other site
425104004878	eyelet of channel; other site
425104004879	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
425104004880	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104004881	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104004882	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104004883	S-adenosylmethionine binding site [chemical binding]; other site
425104004884	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
425104004885	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
425104004886	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
425104004887	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
425104004888	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
425104004889	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
425104004890	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
425104004891	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104004892	TPR motif; other site
425104004893	binding surface
425104004894	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
425104004895	TPR motif; other site
425104004896	binding surface
425104004897	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104004898	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104004899	metal binding site [ion binding]; metal-binding site
425104004900	active site
425104004901	I-site; other site
425104004902	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
425104004903	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
425104004904	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
425104004905	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
425104004906	S4 domain; Region: S4_2; pfam13275
425104004907	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
425104004908	Nuclease-related domain; Region: NERD; pfam08378
425104004909	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
425104004910	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
425104004911	active site
425104004912	ATP binding site [chemical binding]; other site
425104004913	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
425104004914	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104004915	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104004916	dimerization interface [polypeptide binding]; other site
425104004917	hypothetical protein; Provisional; Region: PRK10621
425104004918	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
425104004919	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
425104004920	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
425104004921	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104004922	homodimer interface [polypeptide binding]; other site
425104004923	catalytic residue [active]
425104004924	Predicted membrane protein [Function unknown]; Region: COG3174
425104004925	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
425104004926	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
425104004927	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
425104004928	active site
425104004929	metal binding site [ion binding]; metal-binding site
425104004930	DNA binding site [nucleotide binding]
425104004931	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
425104004932	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
425104004933	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
425104004934	Walker A/P-loop; other site
425104004935	ATP binding site [chemical binding]; other site
425104004936	Q-loop/lid; other site
425104004937	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
425104004938	ABC transporter signature motif; other site
425104004939	Walker B; other site
425104004940	D-loop; other site
425104004941	H-loop/switch region; other site
425104004942	putative peptidase; Provisional; Region: PRK11649
425104004943	Peptidase family M23; Region: Peptidase_M23; pfam01551
425104004944	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
425104004945	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
425104004946	substrate binding pocket [chemical binding]; other site
425104004947	membrane-bound complex binding site; other site
425104004948	hinge residues; other site
425104004949	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
425104004950	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
425104004951	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
425104004952	DEAD-like helicases superfamily; Region: DEXDc; smart00487
425104004953	ATP binding site [chemical binding]; other site
425104004954	Mg++ binding site [ion binding]; other site
425104004955	motif III; other site
425104004956	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104004957	nucleotide binding region [chemical binding]; other site
425104004958	ATP-binding site [chemical binding]; other site
425104004959	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
425104004960	active site
425104004961	nucleophile elbow; other site
425104004962	Prostaglandin dehydrogenases; Region: PGDH; cd05288
425104004963	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
425104004964	NAD(P) binding site [chemical binding]; other site
425104004965	substrate binding site [chemical binding]; other site
425104004966	dimer interface [polypeptide binding]; other site
425104004967	Transcriptional regulators [Transcription]; Region: MarR; COG1846
425104004968	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
425104004969	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
425104004970	ATP cone domain; Region: ATP-cone; pfam03477
425104004971	Class III ribonucleotide reductase; Region: RNR_III; cd01675
425104004972	effector binding site; other site
425104004973	active site
425104004974	Zn binding site [ion binding]; other site
425104004975	glycine loop; other site
425104004976	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
425104004977	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104004978	FeS/SAM binding site; other site
425104004979	hypothetical protein; Provisional; Region: PRK11020
425104004980	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
425104004981	dimerization interface [polypeptide binding]; other site
425104004982	active site
425104004983	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104004984	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104004985	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104004986	putative effector binding pocket; other site
425104004987	dimerization interface [polypeptide binding]; other site
425104004988	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
425104004989	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
425104004990	putative NAD(P) binding site [chemical binding]; other site
425104004991	short chain dehydrogenase; Provisional; Region: PRK12828
425104004992	classical (c) SDRs; Region: SDR_c; cd05233
425104004993	NAD(P) binding site [chemical binding]; other site
425104004994	active site
425104004995	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
425104004996	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
425104004997	non-specific DNA binding site [nucleotide binding]; other site
425104004998	salt bridge; other site
425104004999	sequence-specific DNA binding site [nucleotide binding]; other site
425104005000	Protein of unknown function (DUF3612); Region: DUF3612; pfam12268
425104005001	malate synthase; Provisional; Region: PRK08951
425104005002	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
425104005003	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
425104005004	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
425104005005	active site
425104005006	catalytic residues [active]
425104005007	PA_VapT_like: Protease-associated domain containing proteins like VapT from Vibrio metschnikovii strain RH530. This group contains various PA domain-containing proteins similar to V. metschnikovii VapT, including the serine alkaline protease SapSh from...; Region: PA_VapT_like; cd04817
425104005008	PA/subtilisin-like domain interface [polypeptide binding]; other site
425104005009	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
425104005010	catalytic residues [active]
425104005011	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
425104005012	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
425104005013	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
425104005014	active site residue [active]
425104005015	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
425104005016	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104005017	Protein export membrane protein; Region: SecD_SecF; cl14618
425104005018	Protein export membrane protein; Region: SecD_SecF; cl14618
425104005019	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104005020	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
425104005021	carboxyltransferase (CT) interaction site; other site
425104005022	biotinylation site [posttranslational modification]; other site
425104005023	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
425104005024	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
425104005025	active site
425104005026	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104005027	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
425104005028	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
425104005029	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
425104005030	Na binding site [ion binding]; other site
425104005031	Protein of unknown function (DUF3379); Region: DUF3379; pfam11859
425104005032	RNA polymerase sigma factor; Provisional; Region: PRK12517
425104005033	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
425104005034	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
425104005035	DNA binding residues [nucleotide binding]
425104005036	Oxygen tolerance; Region: BatD; pfam13584
425104005037	Aerotolerance regulator N-terminal; Region: BatA; cl06567
425104005038	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
425104005039	metal ion-dependent adhesion site (MIDAS); other site
425104005040	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104005041	binding surface
425104005042	TPR motif; other site
425104005043	Tetratricopeptide repeat; Region: TPR_16; pfam13432
425104005044	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
425104005045	metal ion-dependent adhesion site (MIDAS); other site
425104005046	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
425104005047	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
425104005048	Protein of unknown function DUF58; Region: DUF58; pfam01882
425104005049	Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141
425104005050	MoxR-like ATPases [General function prediction only]; Region: COG0714
425104005051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104005052	Walker A motif; other site
425104005053	ATP binding site [chemical binding]; other site
425104005054	Walker B motif; other site
425104005055	arginine finger; other site
425104005056	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
425104005057	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
425104005058	dimer interface [polypeptide binding]; other site
425104005059	active site
425104005060	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
425104005061	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
425104005062	substrate binding site [chemical binding]; other site
425104005063	oxyanion hole (OAH) forming residues; other site
425104005064	trimer interface [polypeptide binding]; other site
425104005065	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
425104005066	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
425104005067	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
425104005068	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
425104005069	PAS fold; Region: PAS_3; pfam08447
425104005070	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104005071	PAS domain; Region: PAS_9; pfam13426
425104005072	putative active site [active]
425104005073	heme pocket [chemical binding]; other site
425104005074	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104005075	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104005076	metal binding site [ion binding]; metal-binding site
425104005077	active site
425104005078	I-site; other site
425104005079	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104005080	Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025
425104005081	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
425104005082	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
425104005083	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
425104005084	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
425104005085	catalytic core [active]
425104005086	hypothetical protein; Provisional; Region: PRK04946
425104005087	Smr domain; Region: Smr; pfam01713
425104005088	HemK family putative methylases; Region: hemK_fam; TIGR00536
425104005089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104005090	S-adenosylmethionine binding site [chemical binding]; other site
425104005091	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
425104005092	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
425104005093	Tetramer interface [polypeptide binding]; other site
425104005094	active site
425104005095	FMN-binding site [chemical binding]; other site
425104005096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104005097	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
425104005098	putative substrate translocation pore; other site
425104005099	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
425104005100	YfcL protein; Region: YfcL; pfam08891
425104005101	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
425104005102	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
425104005103	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
425104005104	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
425104005105	dimer interface [polypeptide binding]; other site
425104005106	active site
425104005107	Response regulator receiver domain; Region: Response_reg; pfam00072
425104005108	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104005109	active site
425104005110	phosphorylation site [posttranslational modification]
425104005111	intermolecular recognition site; other site
425104005112	dimerization interface [polypeptide binding]; other site
425104005113	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104005114	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104005115	metal binding site [ion binding]; metal-binding site
425104005116	active site
425104005117	I-site; other site
425104005118	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
425104005119	CheB methylesterase; Region: CheB_methylest; pfam01339
425104005120	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
425104005121	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
425104005122	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
425104005123	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104005124	dimerization interface [polypeptide binding]; other site
425104005125	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104005126	dimer interface [polypeptide binding]; other site
425104005127	phosphorylation site [posttranslational modification]
425104005128	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104005129	ATP binding site [chemical binding]; other site
425104005130	Mg2+ binding site [ion binding]; other site
425104005131	G-X-G motif; other site
425104005132	Response regulator receiver domain; Region: Response_reg; pfam00072
425104005133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104005134	active site
425104005135	phosphorylation site [posttranslational modification]
425104005136	intermolecular recognition site; other site
425104005137	dimerization interface [polypeptide binding]; other site
425104005138	Response regulator receiver domain; Region: Response_reg; pfam00072
425104005139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104005140	active site
425104005141	phosphorylation site [posttranslational modification]
425104005142	intermolecular recognition site; other site
425104005143	dimerization interface [polypeptide binding]; other site
425104005144	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
425104005145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104005146	active site
425104005147	phosphorylation site [posttranslational modification]
425104005148	intermolecular recognition site; other site
425104005149	dimerization interface [polypeptide binding]; other site
425104005150	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
425104005151	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
425104005152	ligand binding site [chemical binding]; other site
425104005153	NAD binding site [chemical binding]; other site
425104005154	catalytic site [active]
425104005155	homodimer interface [polypeptide binding]; other site
425104005156	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
425104005157	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
425104005158	FimV N-terminal domain; Region: FimV_core; TIGR03505
425104005159	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
425104005160	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
425104005161	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
425104005162	dimerization interface 3.5A [polypeptide binding]; other site
425104005163	active site
425104005164	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
425104005165	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
425104005166	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
425104005167	cell division protein DedD; Provisional; Region: PRK11633
425104005168	Sporulation related domain; Region: SPOR; pfam05036
425104005169	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
425104005170	Colicin V production protein; Region: Colicin_V; cl00567
425104005171	amidophosphoribosyltransferase; Provisional; Region: PRK09246
425104005172	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
425104005173	active site
425104005174	tetramer interface [polypeptide binding]; other site
425104005175	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
425104005176	active site
425104005177	DNA topoisomerase III; Provisional; Region: PRK07726
425104005178	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
425104005179	active site
425104005180	putative interdomain interaction site [polypeptide binding]; other site
425104005181	putative metal-binding site [ion binding]; other site
425104005182	putative nucleotide binding site [chemical binding]; other site
425104005183	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
425104005184	domain I; other site
425104005185	DNA binding groove [nucleotide binding]
425104005186	phosphate binding site [ion binding]; other site
425104005187	domain II; other site
425104005188	domain III; other site
425104005189	nucleotide binding site [chemical binding]; other site
425104005190	catalytic site [active]
425104005191	domain IV; other site
425104005192	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
425104005193	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
425104005194	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
425104005195	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
425104005196	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
425104005197	HAMP domain; Region: HAMP; pfam00672
425104005198	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104005199	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104005200	dimer interface [polypeptide binding]; other site
425104005201	putative CheW interface [polypeptide binding]; other site
425104005202	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
425104005203	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
425104005204	active site
425104005205	FMN binding site [chemical binding]; other site
425104005206	2,4-decadienoyl-CoA binding site; other site
425104005207	catalytic residue [active]
425104005208	4Fe-4S cluster binding site [ion binding]; other site
425104005209	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
425104005210	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
425104005211	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
425104005212	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
425104005213	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104005214	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492
425104005215	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
425104005216	acyl-activating enzyme (AAE) consensus motif; other site
425104005217	putative AMP binding site [chemical binding]; other site
425104005218	putative active site [active]
425104005219	putative CoA binding site [chemical binding]; other site
425104005220	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
425104005221	putative catalytic site [active]
425104005222	putative phosphate binding site [ion binding]; other site
425104005223	active site
425104005224	metal binding site A [ion binding]; metal-binding site
425104005225	DNA binding site [nucleotide binding]
425104005226	putative AP binding site [nucleotide binding]; other site
425104005227	putative metal binding site B [ion binding]; other site
425104005228	YciI-like protein; Reviewed; Region: PRK11370
425104005229	intracellular septation protein A; Reviewed; Region: PRK00259
425104005230	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
425104005231	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104005232	Walker A motif; other site
425104005233	ATP binding site [chemical binding]; other site
425104005234	Walker B motif; other site
425104005235	arginine finger; other site
425104005236	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
425104005237	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104005238	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
425104005239	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104005240	N-terminal plug; other site
425104005241	ligand-binding site [chemical binding]; other site
425104005242	nickel responsive regulator; Provisional; Region: PRK00630
425104005243	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
425104005244	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
425104005245	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
425104005246	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
425104005247	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
425104005248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104005249	dimer interface [polypeptide binding]; other site
425104005250	conserved gate region; other site
425104005251	putative PBP binding loops; other site
425104005252	ABC-ATPase subunit interface; other site
425104005253	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
425104005254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104005255	dimer interface [polypeptide binding]; other site
425104005256	conserved gate region; other site
425104005257	putative PBP binding loops; other site
425104005258	ABC-ATPase subunit interface; other site
425104005259	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
425104005260	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104005261	Walker A/P-loop; other site
425104005262	ATP binding site [chemical binding]; other site
425104005263	Q-loop/lid; other site
425104005264	ABC transporter signature motif; other site
425104005265	Walker B; other site
425104005266	D-loop; other site
425104005267	H-loop/switch region; other site
425104005268	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104005269	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
425104005270	Walker A/P-loop; other site
425104005271	ATP binding site [chemical binding]; other site
425104005272	Q-loop/lid; other site
425104005273	ABC transporter signature motif; other site
425104005274	Walker B; other site
425104005275	D-loop; other site
425104005276	H-loop/switch region; other site
425104005277	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
425104005278	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
425104005279	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104005280	Zn2+ binding site [ion binding]; other site
425104005281	Mg2+ binding site [ion binding]; other site
425104005282	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
425104005283	substrate binding site [chemical binding]; other site
425104005284	active site
425104005285	catalytic residues [active]
425104005286	heterodimer interface [polypeptide binding]; other site
425104005287	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
425104005288	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
425104005289	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104005290	catalytic residue [active]
425104005291	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
425104005292	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
425104005293	active site
425104005294	ribulose/triose binding site [chemical binding]; other site
425104005295	phosphate binding site [ion binding]; other site
425104005296	substrate (anthranilate) binding pocket [chemical binding]; other site
425104005297	product (indole) binding pocket [chemical binding]; other site
425104005298	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
425104005299	active site
425104005300	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
425104005301	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
425104005302	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
425104005303	Glutamine amidotransferase class-I; Region: GATase; pfam00117
425104005304	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
425104005305	glutamine binding [chemical binding]; other site
425104005306	catalytic triad [active]
425104005307	anthranilate synthase component I; Provisional; Region: PRK13564
425104005308	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
425104005309	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
425104005310	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
425104005311	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
425104005312	active site
425104005313	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
425104005314	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
425104005315	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
425104005316	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
425104005317	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
425104005318	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
425104005319	RNA binding surface [nucleotide binding]; other site
425104005320	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
425104005321	probable active site [active]
425104005322	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
425104005323	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104005324	NAD(P) binding site [chemical binding]; other site
425104005325	active site
425104005326	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
425104005327	Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262
425104005328	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
425104005329	putative inner membrane peptidase; Provisional; Region: PRK11778
425104005330	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
425104005331	tandem repeat interface [polypeptide binding]; other site
425104005332	oligomer interface [polypeptide binding]; other site
425104005333	active site residues [active]
425104005334	Protein of unknown function, DUF481; Region: DUF481; pfam04338
425104005335	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
425104005336	active site
425104005337	catalytic triad [active]
425104005338	oxyanion hole [active]
425104005339	switch loop; other site
425104005340	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
425104005341	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
425104005342	Walker A/P-loop; other site
425104005343	ATP binding site [chemical binding]; other site
425104005344	Q-loop/lid; other site
425104005345	ABC transporter signature motif; other site
425104005346	Walker B; other site
425104005347	D-loop; other site
425104005348	H-loop/switch region; other site
425104005349	FtsX-like permease family; Region: FtsX; pfam02687
425104005350	FtsX-like permease family; Region: FtsX; pfam02687
425104005351	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
425104005352	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
425104005353	putative NAD(P) binding site [chemical binding]; other site
425104005354	putative active site [active]
425104005355	Domain of unknown function DUF20; Region: UPF0118; pfam01594
425104005356	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
425104005357	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
425104005358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104005359	S-adenosylmethionine binding site [chemical binding]; other site
425104005360	phosphate acetyltransferase; Reviewed; Region: PRK05632
425104005361	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
425104005362	DRTGG domain; Region: DRTGG; pfam07085
425104005363	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
425104005364	propionate/acetate kinase; Provisional; Region: PRK12379
425104005365	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
425104005366	Protein of unknown function, DUF412; Region: DUF412; pfam04217
425104005367	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
425104005368	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104005369	FeS/SAM binding site; other site
425104005370	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
425104005371	Pyruvate formate lyase 1; Region: PFL1; cd01678
425104005372	coenzyme A binding site [chemical binding]; other site
425104005373	active site
425104005374	catalytic residues [active]
425104005375	glycine loop; other site
425104005376	Protein of unknown function (DUF3360); Region: DUF3360; pfam11840
425104005377	formate transporter FocA; Region: formate_focA; TIGR04060
425104005378	FOG: CBS domain [General function prediction only]; Region: COG0517
425104005379	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
425104005380	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
425104005381	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104005382	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
425104005383	putative dimerization interface [polypeptide binding]; other site
425104005384	Protein of unknown function (DUF997); Region: DUF997; cl01614
425104005385	sodium/panthothenate symporter; Provisional; Region: panF; PRK09442
425104005386	Na binding site [ion binding]; other site
425104005387	hypothetical protein; Provisional; Region: PRK11588
425104005388	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
425104005389	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
425104005390	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
425104005391	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104005392	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
425104005393	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
425104005394	gating phenylalanine in ion channel; other site
425104005395	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
425104005396	FOG: CBS domain [General function prediction only]; Region: COG0517
425104005397	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
425104005398	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104005399	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104005400	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
425104005401	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
425104005402	dimer interface [polypeptide binding]; other site
425104005403	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104005404	catalytic residue [active]
425104005405	RDD family; Region: RDD; pfam06271
425104005406	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
425104005407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104005408	active site
425104005409	phosphorylation site [posttranslational modification]
425104005410	intermolecular recognition site; other site
425104005411	dimerization interface [polypeptide binding]; other site
425104005412	Response regulator receiver domain; Region: Response_reg; pfam00072
425104005413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104005414	active site
425104005415	phosphorylation site [posttranslational modification]
425104005416	intermolecular recognition site; other site
425104005417	dimerization interface [polypeptide binding]; other site
425104005418	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104005419	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104005420	metal binding site [ion binding]; metal-binding site
425104005421	active site
425104005422	I-site; other site
425104005423	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104005424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104005425	The C-terminal substrate binding domain of LysR-type transcriptional regulator PnbR, which is involved in regulating the pnb genes encoding enzymes for 4-nitrobenzoate catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_PnbR; cd08469
425104005426	putative substrate binding pocket [chemical binding]; other site
425104005427	putative dimerization interface [polypeptide binding]; other site
425104005428	short chain dehydrogenase; Provisional; Region: PRK06180
425104005429	DoxX-like family; Region: DoxX_2; pfam13564
425104005430	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104005431	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104005432	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104005433	putative effector binding pocket; other site
425104005434	dimerization interface [polypeptide binding]; other site
425104005435	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
425104005436	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
425104005437	reductive dehalogenase; Region: RDH; TIGR02486
425104005438	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
425104005439	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
425104005440	putative ligand binding site [chemical binding]; other site
425104005441	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
425104005442	putative sulfate transport protein CysZ; Validated; Region: PRK04949
425104005443	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
425104005444	AAA domain; Region: AAA_23; pfam13476
425104005445	Walker A/P-loop; other site
425104005446	ATP binding site [chemical binding]; other site
425104005447	Q-loop/lid; other site
425104005448	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
425104005449	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
425104005450	ABC transporter signature motif; other site
425104005451	Walker B; other site
425104005452	D-loop; other site
425104005453	H-loop/switch region; other site
425104005454	Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115
425104005455	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
425104005456	FtsZ protein binding site [polypeptide binding]; other site
425104005457	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
425104005458	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
425104005459	nucleotide binding pocket [chemical binding]; other site
425104005460	K-X-D-G motif; other site
425104005461	catalytic site [active]
425104005462	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
425104005463	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
425104005464	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
425104005465	Dimer interface [polypeptide binding]; other site
425104005466	BRCT sequence motif; other site
425104005467	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
425104005468	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
425104005469	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
425104005470	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104005471	Zn2+ binding site [ion binding]; other site
425104005472	Mg2+ binding site [ion binding]; other site
425104005473	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
425104005474	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
425104005475	putative NAD(P) binding site [chemical binding]; other site
425104005476	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
425104005477	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
425104005478	catalytic residues [active]
425104005479	hinge region; other site
425104005480	alpha helical domain; other site
425104005481	Mor transcription activator family; Region: Mor; cl02360
425104005482	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
425104005483	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
425104005484	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
425104005485	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
425104005486	Na binding site [ion binding]; other site
425104005487	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
425104005488	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
425104005489	active site
425104005490	metal binding site [ion binding]; metal-binding site
425104005491	Bacterial Ig-like domain; Region: Big_5; pfam13205
425104005492	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
425104005493	Interdomain contacts; other site
425104005494	Cytokine receptor motif; other site
425104005495	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104005496	binding surface
425104005497	TPR motif; other site
425104005498	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
425104005499	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
425104005500	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
425104005501	ligand binding site [chemical binding]; other site
425104005502	flexible hinge region; other site
425104005503	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
425104005504	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
425104005505	metal binding triad; other site
425104005506	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
425104005507	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
425104005508	active site
425104005509	catalytic site [active]
425104005510	substrate binding site [chemical binding]; other site
425104005511	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104005512	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104005513	dimer interface [polypeptide binding]; other site
425104005514	phosphorylation site [posttranslational modification]
425104005515	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104005516	ATP binding site [chemical binding]; other site
425104005517	Mg2+ binding site [ion binding]; other site
425104005518	G-X-G motif; other site
425104005519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104005520	Response regulator receiver domain; Region: Response_reg; pfam00072
425104005521	active site
425104005522	phosphorylation site [posttranslational modification]
425104005523	intermolecular recognition site; other site
425104005524	dimerization interface [polypeptide binding]; other site
425104005525	Heme NO binding; Region: HNOB; pfam07700
425104005526	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
425104005527	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
425104005528	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
425104005529	ligand binding site [chemical binding]; other site
425104005530	homodimer interface [polypeptide binding]; other site
425104005531	NAD(P) binding site [chemical binding]; other site
425104005532	trimer interface B [polypeptide binding]; other site
425104005533	trimer interface A [polypeptide binding]; other site
425104005534	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
425104005535	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
425104005536	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
425104005537	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
425104005538	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
425104005539	dimer interface [polypeptide binding]; other site
425104005540	active site
425104005541	CoA binding pocket [chemical binding]; other site
425104005542	Transcriptional regulators [Transcription]; Region: GntR; COG1802
425104005543	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
425104005544	DNA-binding site [nucleotide binding]; DNA binding site
425104005545	FCD domain; Region: FCD; pfam07729
425104005546	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
425104005547	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
425104005548	dimer interface [polypeptide binding]; other site
425104005549	NADP binding site [chemical binding]; other site
425104005550	catalytic residues [active]
425104005551	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
425104005552	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
425104005553	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
425104005554	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
425104005555	inhibitor site; inhibition site
425104005556	active site
425104005557	dimer interface [polypeptide binding]; other site
425104005558	catalytic residue [active]
425104005559	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
425104005560	Proline racemase; Region: Pro_racemase; pfam05544
425104005561	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
425104005562	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
425104005563	hydroxyglutarate oxidase; Provisional; Region: PRK11728
425104005564	Methyltransferase domain; Region: Methyltransf_23; pfam13489
425104005565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104005566	S-adenosylmethionine binding site [chemical binding]; other site
425104005567	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
425104005568	hypothetical protein; Provisional; Region: PRK10318
425104005569	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
425104005570	HD domain; Region: HD_4; pfam13328
425104005571	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
425104005572	PLD-like domain; Region: PLDc_2; pfam13091
425104005573	putative active site [active]
425104005574	catalytic site [active]
425104005575	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
425104005576	PLD-like domain; Region: PLDc_2; pfam13091
425104005577	putative active site [active]
425104005578	catalytic site [active]
425104005579	Transcriptional regulators [Transcription]; Region: MarR; COG1846
425104005580	MarR family; Region: MarR; pfam01047
425104005581	MarR family; Region: MarR_2; cl17246
425104005582	BCCT family transporter; Region: BCCT; cl00569
425104005583	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
425104005584	SnoaL-like domain; Region: SnoaL_2; pfam12680
425104005585	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104005586	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104005587	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104005588	dimerization interface [polypeptide binding]; other site
425104005589	haloalkane dehalogenase; Provisional; Region: PRK00870
425104005590	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
425104005591	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
425104005592	putative NAD(P) binding site [chemical binding]; other site
425104005593	homodimer interface [polypeptide binding]; other site
425104005594	amino acid transporter; Region: 2A0306; TIGR00909
425104005595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
425104005596	active site
425104005597	phosphorylation site [posttranslational modification]
425104005598	intermolecular recognition site; other site
425104005599	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
425104005600	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104005601	Zn2+ binding site [ion binding]; other site
425104005602	Mg2+ binding site [ion binding]; other site
425104005603	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104005604	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104005605	ATP binding site [chemical binding]; other site
425104005606	Mg2+ binding site [ion binding]; other site
425104005607	G-X-G motif; other site
425104005608	proline aminopeptidase P II; Provisional; Region: PRK10879
425104005609	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
425104005610	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
425104005611	active site
425104005612	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
425104005613	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104005614	active site
425104005615	motif I; other site
425104005616	motif II; other site
425104005617	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
425104005618	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
425104005619	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
425104005620	Cl binding site [ion binding]; other site
425104005621	oligomer interface [polypeptide binding]; other site
425104005622	Protein of unknown function (DUF3135); Region: DUF3135; pfam11333
425104005623	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
425104005624	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
425104005625	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104005626	Zn2+ binding site [ion binding]; other site
425104005627	Mg2+ binding site [ion binding]; other site
425104005628	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
425104005629	sensor protein PhoQ; Provisional; Region: PRK10815
425104005630	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104005631	ATP binding site [chemical binding]; other site
425104005632	Mg2+ binding site [ion binding]; other site
425104005633	G-X-G motif; other site
425104005634	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
425104005635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104005636	active site
425104005637	phosphorylation site [posttranslational modification]
425104005638	intermolecular recognition site; other site
425104005639	dimerization interface [polypeptide binding]; other site
425104005640	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104005641	DNA binding site [nucleotide binding]
425104005642	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
425104005643	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
425104005644	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104005645	Walker A/P-loop; other site
425104005646	ATP binding site [chemical binding]; other site
425104005647	Q-loop/lid; other site
425104005648	ABC transporter signature motif; other site
425104005649	Walker B; other site
425104005650	D-loop; other site
425104005651	H-loop/switch region; other site
425104005652	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
425104005653	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
425104005654	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
425104005655	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104005656	HAMP domain; Region: HAMP; pfam00672
425104005657	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
425104005658	dimer interface [polypeptide binding]; other site
425104005659	phosphorylation site [posttranslational modification]
425104005660	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104005661	ATP binding site [chemical binding]; other site
425104005662	Mg2+ binding site [ion binding]; other site
425104005663	G-X-G motif; other site
425104005664	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
425104005665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104005666	active site
425104005667	phosphorylation site [posttranslational modification]
425104005668	intermolecular recognition site; other site
425104005669	dimerization interface [polypeptide binding]; other site
425104005670	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104005671	Walker A motif; other site
425104005672	ATP binding site [chemical binding]; other site
425104005673	Walker B motif; other site
425104005674	arginine finger; other site
425104005675	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104005676	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
425104005677	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
425104005678	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104005679	Zn2+ binding site [ion binding]; other site
425104005680	Mg2+ binding site [ion binding]; other site
425104005681	LysE type translocator; Region: LysE; cl00565
425104005682	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
425104005683	Helix-turn-helix domain; Region: HTH_18; pfam12833
425104005684	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104005685	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
425104005686	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
425104005687	homodimer interface [polypeptide binding]; other site
425104005688	NAD binding pocket [chemical binding]; other site
425104005689	ATP binding pocket [chemical binding]; other site
425104005690	Mg binding site [ion binding]; other site
425104005691	active-site loop [active]
425104005692	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
425104005693	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
425104005694	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104005695	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104005696	metal binding site [ion binding]; metal-binding site
425104005697	active site
425104005698	I-site; other site
425104005699	elongation factor P; Provisional; Region: PRK04542
425104005700	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
425104005701	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
425104005702	RNA binding site [nucleotide binding]; other site
425104005703	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
425104005704	RNA binding site [nucleotide binding]; other site
425104005705	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
425104005706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104005707	Walker A/P-loop; other site
425104005708	ATP binding site [chemical binding]; other site
425104005709	Q-loop/lid; other site
425104005710	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104005711	ABC transporter signature motif; other site
425104005712	Walker B; other site
425104005713	D-loop; other site
425104005714	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104005715	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
425104005716	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
425104005717	Sulfatase; Region: Sulfatase; cl17466
425104005718	hypothetical protein; Provisional; Region: PRK13689
425104005719	Nucleoid-associated protein [General function prediction only]; Region: COG3081
425104005720	nucleoid-associated protein NdpA; Validated; Region: PRK00378
425104005721	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
425104005722	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
425104005723	Peptidase family M23; Region: Peptidase_M23; pfam01551
425104005724	Phytochelatin synthase; Region: Phytochelatin; pfam05023
425104005725	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
425104005726	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104005727	N-terminal plug; other site
425104005728	ligand-binding site [chemical binding]; other site
425104005729	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
425104005730	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
425104005731	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104005732	Coenzyme A binding pocket [chemical binding]; other site
425104005733	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
425104005734	Na binding site [ion binding]; other site
425104005735	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
425104005736	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104005737	FeS/SAM binding site; other site
425104005738	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
425104005739	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
425104005740	putative metal binding site [ion binding]; other site
425104005741	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
425104005742	Ion transport protein; Region: Ion_trans; pfam00520
425104005743	Ion channel; Region: Ion_trans_2; pfam07885
425104005744	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
425104005745	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
425104005746	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
425104005747	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
425104005748	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
425104005749	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
425104005750	Nitrogen regulatory protein P-II; Region: P-II; smart00938
425104005751	FOG: CBS domain [General function prediction only]; Region: COG0517
425104005752	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
425104005753	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
425104005754	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
425104005755	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
425104005756	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
425104005757	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
425104005758	hypothetical protein; Provisional; Region: PRK05713
425104005759	catalytic loop [active]
425104005760	iron binding site [ion binding]; other site
425104005761	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
425104005762	FAD binding pocket [chemical binding]; other site
425104005763	FAD binding motif [chemical binding]; other site
425104005764	phosphate binding motif [ion binding]; other site
425104005765	beta-alpha-beta structure motif; other site
425104005766	NAD binding pocket [chemical binding]; other site
425104005767	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
425104005768	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104005769	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104005770	Coenzyme A binding pocket [chemical binding]; other site
425104005771	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
425104005772	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104005773	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
425104005774	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
425104005775	putative substrate binding pocket [chemical binding]; other site
425104005776	trimer interface [polypeptide binding]; other site
425104005777	asparagine synthetase B; Provisional; Region: asnB; PRK09431
425104005778	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
425104005779	active site
425104005780	dimer interface [polypeptide binding]; other site
425104005781	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
425104005782	Ligand Binding Site [chemical binding]; other site
425104005783	Molecular Tunnel; other site
425104005784	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
425104005785	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
425104005786	PA/protease or protease-like domain interface [polypeptide binding]; other site
425104005787	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
425104005788	Peptidase family M28; Region: Peptidase_M28; pfam04389
425104005789	metal binding site [ion binding]; metal-binding site
425104005790	UMP phosphatase; Provisional; Region: PRK10444
425104005791	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104005792	active site
425104005793	motif I; other site
425104005794	motif II; other site
425104005795	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104005796	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
425104005797	Beta-lactamase; Region: Beta-lactamase; pfam00144
425104005798	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
425104005799	Beta-lactamase; Region: Beta-lactamase; pfam00144
425104005800	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
425104005801	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
425104005802	active site
425104005803	substrate binding site [chemical binding]; other site
425104005804	cosubstrate binding site; other site
425104005805	catalytic site [active]
425104005806	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
425104005807	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
425104005808	dimerization interface [polypeptide binding]; other site
425104005809	putative ATP binding site [chemical binding]; other site
425104005810	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
425104005811	active site
425104005812	Predicted permease [General function prediction only]; Region: COG2056
425104005813	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
425104005814	peroxidase; Provisional; Region: PRK15000
425104005815	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
425104005816	dimer interface [polypeptide binding]; other site
425104005817	decamer (pentamer of dimers) interface [polypeptide binding]; other site
425104005818	catalytic triad [active]
425104005819	peroxidatic and resolving cysteines [active]
425104005820	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
425104005821	putative deacylase active site [active]
425104005822	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
425104005823	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
425104005824	dimer interface [polypeptide binding]; other site
425104005825	catalytic site [active]
425104005826	putative active site [active]
425104005827	putative substrate binding site [chemical binding]; other site
425104005828	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
425104005829	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
425104005830	ligand binding site [chemical binding]; other site
425104005831	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
425104005832	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104005833	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
425104005834	active site
425104005835	TolQ protein; Region: tolQ; TIGR02796
425104005836	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
425104005837	TolR protein; Region: tolR; TIGR02801
425104005838	TolA C-terminal; Region: TolA; pfam06519
425104005839	TolA protein; Region: tolA_full; TIGR02794
425104005840	translocation protein TolB; Provisional; Region: tolB; PRK04792
425104005841	TolB amino-terminal domain; Region: TolB_N; pfam04052
425104005842	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
425104005843	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
425104005844	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
425104005845	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
425104005846	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
425104005847	ligand binding site [chemical binding]; other site
425104005848	tol-pal system protein YbgF; Provisional; Region: PRK10803
425104005849	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104005850	binding surface
425104005851	TPR motif; other site
425104005852	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
425104005853	GSH binding site [chemical binding]; other site
425104005854	catalytic residues [active]
425104005855	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
425104005856	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104005857	ATP binding site [chemical binding]; other site
425104005858	putative Mg++ binding site [ion binding]; other site
425104005859	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104005860	nucleotide binding region [chemical binding]; other site
425104005861	ATP-binding site [chemical binding]; other site
425104005862	Double zinc ribbon; Region: DZR; pfam12773
425104005863	acetyl-CoA synthetase; Provisional; Region: PRK00174
425104005864	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
425104005865	active site
425104005866	CoA binding site [chemical binding]; other site
425104005867	acyl-activating enzyme (AAE) consensus motif; other site
425104005868	AMP binding site [chemical binding]; other site
425104005869	acetate binding site [chemical binding]; other site
425104005870	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
425104005871	Na binding site [ion binding]; other site
425104005872	PAS domain; Region: PAS; smart00091
425104005873	PAS fold; Region: PAS_7; pfam12860
425104005874	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104005875	dimer interface [polypeptide binding]; other site
425104005876	phosphorylation site [posttranslational modification]
425104005877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104005878	ATP binding site [chemical binding]; other site
425104005879	Mg2+ binding site [ion binding]; other site
425104005880	G-X-G motif; other site
425104005881	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
425104005882	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104005883	active site
425104005884	phosphorylation site [posttranslational modification]
425104005885	intermolecular recognition site; other site
425104005886	dimerization interface [polypeptide binding]; other site
425104005887	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
425104005888	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
425104005889	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
425104005890	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
425104005891	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
425104005892	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104005893	active site
425104005894	phosphorylation site [posttranslational modification]
425104005895	intermolecular recognition site; other site
425104005896	dimerization interface [polypeptide binding]; other site
425104005897	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104005898	DNA binding residues [nucleotide binding]
425104005899	dimerization interface [polypeptide binding]; other site
425104005900	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
425104005901	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
425104005902	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
425104005903	PEP synthetase regulatory protein; Provisional; Region: PRK05339
425104005904	phosphoenolpyruvate synthase; Validated; Region: PRK06464
425104005905	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
425104005906	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
425104005907	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
425104005908	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
425104005909	FAD binding domain; Region: FAD_binding_4; pfam01565
425104005910	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
425104005911	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
425104005912	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
425104005913	MarR family; Region: MarR_2; pfam12802
425104005914	Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632
425104005915	dimer interface [polypeptide binding]; other site
425104005916	putative inhibitory loop; other site
425104005917	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
425104005918	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
425104005919	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
425104005920	NAD binding site [chemical binding]; other site
425104005921	Phe binding site; other site
425104005922	adenylosuccinate lyase; Provisional; Region: PRK09285
425104005923	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
425104005924	tetramer interface [polypeptide binding]; other site
425104005925	active site
425104005926	putative lysogenization regulator; Reviewed; Region: PRK00218
425104005927	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
425104005928	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
425104005929	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
425104005930	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
425104005931	active site
425104005932	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
425104005933	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
425104005934	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
425104005935	DNA-binding site [nucleotide binding]; DNA binding site
425104005936	RNA-binding motif; other site
425104005937	Uncharacterized conserved protein [Function unknown]; Region: COG2127
425104005938	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
425104005939	Clp amino terminal domain; Region: Clp_N; pfam02861
425104005940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104005941	Walker A motif; other site
425104005942	ATP binding site [chemical binding]; other site
425104005943	Walker B motif; other site
425104005944	arginine finger; other site
425104005945	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104005946	Walker A motif; other site
425104005947	ATP binding site [chemical binding]; other site
425104005948	Walker B motif; other site
425104005949	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
425104005950	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
425104005951	rRNA binding site [nucleotide binding]; other site
425104005952	predicted 30S ribosome binding site; other site
425104005953	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
425104005954	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
425104005955	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
425104005956	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
425104005957	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
425104005958	Uncharacterized conserved protein [Function unknown]; Region: COG0327
425104005959	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
425104005960	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
425104005961	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
425104005962	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104005963	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
425104005964	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104005965	putative substrate translocation pore; other site
425104005966	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
425104005967	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
425104005968	dimerization interface [polypeptide binding]; other site
425104005969	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
425104005970	ATP binding site [chemical binding]; other site
425104005971	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
425104005972	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
425104005973	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298
425104005974	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
425104005975	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
425104005976	G1 box; other site
425104005977	GTP/Mg2+ binding site [chemical binding]; other site
425104005978	G2 box; other site
425104005979	Switch I region; other site
425104005980	G3 box; other site
425104005981	Switch II region; other site
425104005982	G4 box; other site
425104005983	G5 box; other site
425104005984	Acylphosphatase; Region: Acylphosphatase; pfam00708
425104005985	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
425104005986	HypF finger; Region: zf-HYPF; pfam07503
425104005987	HypF finger; Region: zf-HYPF; pfam07503
425104005988	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
425104005989	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
425104005990	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
425104005991	putative substrate-binding site; other site
425104005992	nickel binding site [ion binding]; other site
425104005993	Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125
425104005994	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
425104005995	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
425104005996	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
425104005997	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
425104005998	FOG: CBS domain [General function prediction only]; Region: COG0517
425104005999	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
425104006000	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104006001	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104006002	substrate binding pocket [chemical binding]; other site
425104006003	membrane-bound complex binding site; other site
425104006004	hinge residues; other site
425104006005	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
425104006006	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104006007	ATP binding site [chemical binding]; other site
425104006008	putative Mg++ binding site [ion binding]; other site
425104006009	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104006010	nucleotide binding region [chemical binding]; other site
425104006011	ATP-binding site [chemical binding]; other site
425104006012	Helicase associated domain (HA2); Region: HA2; pfam04408
425104006013	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
425104006014	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
425104006015	NapD protein; Region: NapD; pfam03927
425104006016	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
425104006017	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
425104006018	[4Fe-4S] binding site [ion binding]; other site
425104006019	molybdopterin cofactor binding site; other site
425104006020	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
425104006021	molybdopterin cofactor binding site; other site
425104006022	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
425104006023	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
425104006024	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
425104006025	Protein of unknown function (Duf2374); Region: DUF2374; pfam09574
425104006026	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
425104006027	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104006028	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
425104006029	substrate binding pocket [chemical binding]; other site
425104006030	dimerization interface [polypeptide binding]; other site
425104006031	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
425104006032	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104006033	substrate binding pocket [chemical binding]; other site
425104006034	membrane-bound complex binding site; other site
425104006035	hinge residues; other site
425104006036	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
425104006037	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
425104006038	ATP-grasp domain; Region: ATP-grasp_4; cl17255
425104006039	transcriptional regulator SlyA; Provisional; Region: PRK03573
425104006040	MarR family; Region: MarR_2; cl17246
425104006041	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
425104006042	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104006043	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104006044	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
425104006045	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
425104006046	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
425104006047	ligand binding site [chemical binding]; other site
425104006048	flexible hinge region; other site
425104006049	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
425104006050	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
425104006051	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
425104006052	active site
425104006053	metal binding site [ion binding]; metal-binding site
425104006054	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
425104006055	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
425104006056	Flagellin N-methylase; Region: FliB; cl00497
425104006057	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
425104006058	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
425104006059	putative oxidoreductase; Provisional; Region: PRK13984
425104006060	4Fe-4S binding domain; Region: Fer4; pfam00037
425104006061	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
425104006062	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
425104006063	PAS domain; Region: PAS_9; pfam13426
425104006064	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104006065	putative active site [active]
425104006066	heme pocket [chemical binding]; other site
425104006067	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104006068	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104006069	metal binding site [ion binding]; metal-binding site
425104006070	active site
425104006071	I-site; other site
425104006072	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
425104006073	AAA domain; Region: AAA_30; pfam13604
425104006074	Family description; Region: UvrD_C_2; pfam13538
425104006075	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
425104006076	Part of AAA domain; Region: AAA_19; pfam13245
425104006077	Family description; Region: UvrD_C_2; pfam13538
425104006078	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
425104006079	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
425104006080	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
425104006081	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
425104006082	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104006083	putative substrate translocation pore; other site
425104006084	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
425104006085	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
425104006086	ligand binding site [chemical binding]; other site
425104006087	ATP-grasp domain; Region: ATP-grasp_4; cl17255
425104006088	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
425104006089	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104006090	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
425104006091	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
425104006092	Cytochrome c; Region: Cytochrom_C; cl11414
425104006093	Cytochrome c; Region: Cytochrom_C; pfam00034
425104006094	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
425104006095	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
425104006096	Domain of unknown function DUF87; Region: DUF87; pfam01935
425104006097	AAA-like domain; Region: AAA_10; pfam12846
425104006098	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
425104006099	SIR2-like domain; Region: SIR2_2; pfam13289
425104006100	transcriptional regulator NarL; Provisional; Region: PRK10651
425104006101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104006102	active site
425104006103	phosphorylation site [posttranslational modification]
425104006104	intermolecular recognition site; other site
425104006105	dimerization interface [polypeptide binding]; other site
425104006106	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104006107	DNA binding residues [nucleotide binding]
425104006108	dimerization interface [polypeptide binding]; other site
425104006109	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
425104006110	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
425104006111	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104006112	dimerization interface [polypeptide binding]; other site
425104006113	Histidine kinase; Region: HisKA_3; pfam07730
425104006114	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104006115	ATP binding site [chemical binding]; other site
425104006116	Mg2+ binding site [ion binding]; other site
425104006117	G-X-G motif; other site
425104006118	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
425104006119	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
425104006120	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
425104006121	[4Fe-4S] binding site [ion binding]; other site
425104006122	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
425104006123	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
425104006124	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
425104006125	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
425104006126	molybdopterin cofactor binding site; other site
425104006127	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
425104006128	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
425104006129	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
425104006130	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
425104006131	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
425104006132	HPP family; Region: HPP; pfam04982
425104006133	Protein phosphatase 2C; Region: PP2C; pfam00481
425104006134	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
425104006135	active site
425104006136	Protein kinase domain; Region: Pkinase; pfam00069
425104006137	Catalytic domain of Protein Kinases; Region: PKc; cd00180
425104006138	active site
425104006139	ATP binding site [chemical binding]; other site
425104006140	substrate binding site [chemical binding]; other site
425104006141	activation loop (A-loop); other site
425104006142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104006143	putative substrate translocation pore; other site
425104006144	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104006145	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
425104006146	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
425104006147	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
425104006148	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
425104006149	Protein of unknown function DUF58; Region: DUF58; pfam01882
425104006150	MoxR-like ATPases [General function prediction only]; Region: COG0714
425104006151	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104006152	Walker A motif; other site
425104006153	ATP binding site [chemical binding]; other site
425104006154	Walker B motif; other site
425104006155	arginine finger; other site
425104006156	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104006157	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104006158	DNA binding residues [nucleotide binding]
425104006159	dimerization interface [polypeptide binding]; other site
425104006160	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
425104006161	putative transposase OrfB; Reviewed; Region: PHA02517
425104006162	HTH-like domain; Region: HTH_21; pfam13276
425104006163	Integrase core domain; Region: rve; pfam00665
425104006164	Integrase core domain; Region: rve_3; pfam13683
425104006165	Transposase; Region: HTH_Tnp_1; pfam01527
425104006166	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104006167	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104006168	dimer interface [polypeptide binding]; other site
425104006169	phosphorylation site [posttranslational modification]
425104006170	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
425104006171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104006172	active site
425104006173	phosphorylation site [posttranslational modification]
425104006174	intermolecular recognition site; other site
425104006175	dimerization interface [polypeptide binding]; other site
425104006176	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104006177	DNA binding site [nucleotide binding]
425104006178	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104006179	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104006180	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104006181	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
425104006182	lytic murein transglycosylase; Provisional; Region: PRK11619
425104006183	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
425104006184	N-acetyl-D-glucosamine binding site [chemical binding]; other site
425104006185	catalytic residue [active]
425104006186	RmuC family; Region: RmuC; pfam02646
425104006187	TMAO/DMSO reductase; Reviewed; Region: PRK05363
425104006188	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
425104006189	Moco binding site; other site
425104006190	metal coordination site [ion binding]; other site
425104006191	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
425104006192	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
425104006193	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104006194	dimerization interface [polypeptide binding]; other site
425104006195	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104006196	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104006197	dimer interface [polypeptide binding]; other site
425104006198	putative CheW interface [polypeptide binding]; other site
425104006199	ribonuclease activity regulator protein RraA; Reviewed; Region: PRK12487
425104006200	AsmA family; Region: AsmA; pfam05170
425104006201	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
425104006202	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
425104006203	PAS domain; Region: PAS_9; pfam13426
425104006204	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104006205	putative active site [active]
425104006206	heme pocket [chemical binding]; other site
425104006207	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104006208	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104006209	dimer interface [polypeptide binding]; other site
425104006210	putative CheW interface [polypeptide binding]; other site
425104006211	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
425104006212	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
425104006213	N-acetyl-D-glucosamine binding site [chemical binding]; other site
425104006214	catalytic residue [active]
425104006215	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
425104006216	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
425104006217	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
425104006218	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
425104006219	Methyltransferase domain; Region: Methyltransf_11; pfam08241
425104006220	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
425104006221	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104006222	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
425104006223	putative dimerization interface [polypeptide binding]; other site
425104006224	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
425104006225	RNA/DNA hybrid binding site [nucleotide binding]; other site
425104006226	active site
425104006227	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
425104006228	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
425104006229	active site
425104006230	catalytic site [active]
425104006231	substrate binding site [chemical binding]; other site
425104006232	TIGR03503 family protein; Region: TIGR03503
425104006233	purine nucleoside phosphorylase; Provisional; Region: PRK08202
425104006234	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
425104006235	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104006236	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
425104006237	putative dimerization interface [polypeptide binding]; other site
425104006238	putative substrate binding pocket [chemical binding]; other site
425104006239	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
425104006240	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
425104006241	PA/protease or protease-like domain interface [polypeptide binding]; other site
425104006242	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
425104006243	Peptidase family M28; Region: Peptidase_M28; pfam04389
425104006244	metal binding site [ion binding]; metal-binding site
425104006245	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
425104006246	TrkA-N domain; Region: TrkA_N; pfam02254
425104006247	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
425104006248	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
425104006249	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
425104006250	active site
425104006251	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
425104006252	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
425104006253	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
425104006254	putative active site [active]
425104006255	putative dimer interface [polypeptide binding]; other site
425104006256	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
425104006257	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
425104006258	active site
425104006259	DNA binding site [nucleotide binding]
425104006260	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104006261	putative substrate translocation pore; other site
425104006262	POT family; Region: PTR2; cl17359
425104006263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104006264	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
425104006265	active site
425104006266	catalytic residues [active]
425104006267	metal binding site [ion binding]; metal-binding site
425104006268	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104006269	HAMP domain; Region: HAMP; pfam00672
425104006270	dimerization interface [polypeptide binding]; other site
425104006271	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104006272	dimer interface [polypeptide binding]; other site
425104006273	phosphorylation site [posttranslational modification]
425104006274	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104006275	ATP binding site [chemical binding]; other site
425104006276	Mg2+ binding site [ion binding]; other site
425104006277	G-X-G motif; other site
425104006278	DTW domain; Region: DTW; cl01221
425104006279	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
425104006280	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
425104006281	active site
425104006282	Haemolysin-III related; Region: HlyIII; cl03831
425104006283	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
425104006284	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
425104006285	ThiC-associated domain; Region: ThiC-associated; pfam13667
425104006286	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
425104006287	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
425104006288	dimer interface [polypeptide binding]; other site
425104006289	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
425104006290	substrate binding site [chemical binding]; other site
425104006291	ATP binding site [chemical binding]; other site
425104006292	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
425104006293	thiamine phosphate binding site [chemical binding]; other site
425104006294	active site
425104006295	pyrophosphate binding site [ion binding]; other site
425104006296	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
425104006297	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
425104006298	ATP binding site [chemical binding]; other site
425104006299	substrate interface [chemical binding]; other site
425104006300	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
425104006301	thiS-thiF/thiG interaction site; other site
425104006302	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
425104006303	ThiS interaction site; other site
425104006304	putative active site [active]
425104006305	tetramer interface [polypeptide binding]; other site
425104006306	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
425104006307	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104006308	FeS/SAM binding site; other site
425104006309	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
425104006310	SprA-related family; Region: SprA-related; pfam12118
425104006311	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104006312	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104006313	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104006314	dimerization interface [polypeptide binding]; other site
425104006315	Domain of unknown function (DUF3541); Region: DUF3541; pfam12060
425104006316	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
425104006317	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
425104006318	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
425104006319	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
425104006320	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
425104006321	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
425104006322	Methyltransferase domain; Region: Methyltransf_23; pfam13489
425104006323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104006324	S-adenosylmethionine binding site [chemical binding]; other site
425104006325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104006326	S-adenosylmethionine binding site [chemical binding]; other site
425104006327	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104006328	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104006329	substrate binding pocket [chemical binding]; other site
425104006330	membrane-bound complex binding site; other site
425104006331	hinge residues; other site
425104006332	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104006333	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
425104006334	substrate binding pocket [chemical binding]; other site
425104006335	membrane-bound complex binding site; other site
425104006336	hinge residues; other site
425104006337	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104006338	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104006339	substrate binding pocket [chemical binding]; other site
425104006340	membrane-bound complex binding site; other site
425104006341	hinge residues; other site
425104006342	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104006343	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104006344	metal binding site [ion binding]; metal-binding site
425104006345	active site
425104006346	I-site; other site
425104006347	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
425104006348	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
425104006349	dimer interface [polypeptide binding]; other site
425104006350	anticodon binding site; other site
425104006351	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
425104006352	homodimer interface [polypeptide binding]; other site
425104006353	motif 1; other site
425104006354	active site
425104006355	motif 2; other site
425104006356	GAD domain; Region: GAD; pfam02938
425104006357	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
425104006358	active site
425104006359	motif 3; other site
425104006360	hypothetical protein; Validated; Region: PRK00110
425104006361	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
425104006362	active site
425104006363	putative DNA-binding cleft [nucleotide binding]; other site
425104006364	dimer interface [polypeptide binding]; other site
425104006365	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
425104006366	RuvA N terminal domain; Region: RuvA_N; pfam01330
425104006367	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
425104006368	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
425104006369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104006370	Walker A motif; other site
425104006371	ATP binding site [chemical binding]; other site
425104006372	Walker B motif; other site
425104006373	arginine finger; other site
425104006374	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
425104006375	gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529
425104006376	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
425104006377	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
425104006378	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104006379	N-terminal plug; other site
425104006380	ligand-binding site [chemical binding]; other site
425104006381	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104006382	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
425104006383	dimer interface [polypeptide binding]; other site
425104006384	active site
425104006385	metal binding site [ion binding]; metal-binding site
425104006386	glutathione binding site [chemical binding]; other site
425104006387	endonuclease III; Provisional; Region: PRK10702
425104006388	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
425104006389	minor groove reading motif; other site
425104006390	helix-hairpin-helix signature motif; other site
425104006391	substrate binding pocket [chemical binding]; other site
425104006392	active site
425104006393	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
425104006394	electron transport complex RsxE subunit; Provisional; Region: PRK12405
425104006395	electron transport complex protein RnfG; Validated; Region: PRK01908
425104006396	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
425104006397	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
425104006398	SLBB domain; Region: SLBB; pfam10531
425104006399	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
425104006400	ferredoxin; Provisional; Region: PRK08764
425104006401	Putative Fe-S cluster; Region: FeS; pfam04060
425104006402	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
425104006403	electron transport complex protein RsxA; Provisional; Region: PRK05151
425104006404	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104006405	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104006406	active site
425104006407	I-site; other site
425104006408	metal binding site [ion binding]; metal-binding site
425104006409	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104006410	excinuclease ABC subunit B; Provisional; Region: PRK05298
425104006411	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104006412	ATP binding site [chemical binding]; other site
425104006413	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
425104006414	putative Mg++ binding site [ion binding]; other site
425104006415	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104006416	nucleotide binding region [chemical binding]; other site
425104006417	ATP-binding site [chemical binding]; other site
425104006418	Ultra-violet resistance protein B; Region: UvrB; pfam12344
425104006419	UvrB/uvrC motif; Region: UVR; pfam02151
425104006420	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
425104006421	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
425104006422	Ligand Binding Site [chemical binding]; other site
425104006423	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
425104006424	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
425104006425	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
425104006426	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
425104006427	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
425104006428	catalytic residue [active]
425104006429	Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993
425104006430	Protein of unknown function (DUF406); Region: DUF406; pfam04175
425104006431	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
425104006432	GAF domain; Region: GAF; pfam01590
425104006433	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
425104006434	PAS domain; Region: PAS_9; pfam13426
425104006435	putative active site [active]
425104006436	heme pocket [chemical binding]; other site
425104006437	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104006438	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104006439	metal binding site [ion binding]; metal-binding site
425104006440	active site
425104006441	I-site; other site
425104006442	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104006443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
425104006444	SEC-C motif; Region: SEC-C; pfam02810
425104006445	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
425104006446	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
425104006447	Smr domain; Region: Smr; pfam01713
425104006448	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
425104006449	active site
425104006450	Zn binding site [ion binding]; other site
425104006451	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
425104006452	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
425104006453	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
425104006454	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
425104006455	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
425104006456	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
425104006457	Cation efflux family; Region: Cation_efflux; pfam01545
425104006458	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
425104006459	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
425104006460	Putative esterase; Region: Esterase; pfam00756
425104006461	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
425104006462	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
425104006463	transmembrane helices; other site
425104006464	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104006465	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104006466	acyl-CoA dehydrogenase; Reviewed; Region: PRK13026
425104006467	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
425104006468	active site
425104006469	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
425104006470	pyruvate kinase; Provisional; Region: PRK05826
425104006471	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
425104006472	domain interfaces; other site
425104006473	active site
425104006474	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
425104006475	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
425104006476	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
425104006477	putative active site [active]
425104006478	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
425104006479	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
425104006480	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
425104006481	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
425104006482	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
425104006483	putative active site [active]
425104006484	phosphogluconate dehydratase; Validated; Region: PRK09054
425104006485	6-phosphogluconate dehydratase; Region: edd; TIGR01196
425104006486	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
425104006487	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
425104006488	active site
425104006489	intersubunit interface [polypeptide binding]; other site
425104006490	catalytic residue [active]
425104006491	ecotin; Provisional; Region: PRK03719
425104006492	secondary substrate binding site; other site
425104006493	primary substrate binding site; other site
425104006494	inhibition loop; other site
425104006495	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
425104006496	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
425104006497	MarR family; Region: MarR; pfam01047
425104006498	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104006499	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104006500	metal binding site [ion binding]; metal-binding site
425104006501	active site
425104006502	I-site; other site
425104006503	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
425104006504	CoA binding domain; Region: CoA_binding_2; pfam13380
425104006505	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
425104006506	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
425104006507	lipid kinase; Reviewed; Region: PRK13054
425104006508	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
425104006509	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
425104006510	Precorrin-8X methylmutase; Region: CbiC; pfam02570
425104006511	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
425104006512	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
425104006513	active site
425104006514	putative homodimer interface [polypeptide binding]; other site
425104006515	SAM binding site [chemical binding]; other site
425104006516	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
425104006517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104006518	S-adenosylmethionine binding site [chemical binding]; other site
425104006519	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
425104006520	active site
425104006521	SAM binding site [chemical binding]; other site
425104006522	homodimer interface [polypeptide binding]; other site
425104006523	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
425104006524	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
425104006525	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
425104006526	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
425104006527	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
425104006528	dimer interface [polypeptide binding]; other site
425104006529	[2Fe-2S] cluster binding site [ion binding]; other site
425104006530	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
425104006531	active site
425104006532	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
425104006533	active site
425104006534	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
425104006535	active site
425104006536	SAM binding site [chemical binding]; other site
425104006537	homodimer interface [polypeptide binding]; other site
425104006538	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
425104006539	active site
425104006540	SAM binding site [chemical binding]; other site
425104006541	homodimer interface [polypeptide binding]; other site
425104006542	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
425104006543	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
425104006544	active site
425104006545	SAM binding site [chemical binding]; other site
425104006546	homodimer interface [polypeptide binding]; other site
425104006547	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
425104006548	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
425104006549	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
425104006550	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104006551	homodimer interface [polypeptide binding]; other site
425104006552	catalytic residue [active]
425104006553	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
425104006554	dimerization interface [polypeptide binding]; other site
425104006555	DNA binding residues [nucleotide binding]
425104006556	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
425104006557	Transthyretin-like family; Region: DUF290; pfam01060
425104006558	cobalt transport protein CbiM; Validated; Region: PRK06265
425104006559	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
425104006560	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
425104006561	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
425104006562	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
425104006563	Walker A/P-loop; other site
425104006564	ATP binding site [chemical binding]; other site
425104006565	Q-loop/lid; other site
425104006566	ABC transporter signature motif; other site
425104006567	Walker B; other site
425104006568	D-loop; other site
425104006569	H-loop/switch region; other site
425104006570	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
425104006571	Helix-turn-helix domain; Region: HTH_18; pfam12833
425104006572	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104006573	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
425104006574	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
425104006575	reductive dehalogenase; Region: RDH; TIGR02486
425104006576	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104006577	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104006578	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104006579	putative effector binding pocket; other site
425104006580	dimerization interface [polypeptide binding]; other site
425104006581	TPR repeat; Region: TPR_11; pfam13414
425104006582	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104006583	binding surface
425104006584	TPR motif; other site
425104006585	TPR repeat; Region: TPR_11; pfam13414
425104006586	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
425104006587	binding surface
425104006588	TPR motif; other site
425104006589	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
425104006590	reductive dehalogenase; Region: RDH; TIGR02486
425104006591	FMN-binding domain; Region: FMN_bind; pfam04205
425104006592	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
425104006593	Helix-turn-helix domain; Region: HTH_18; pfam12833
425104006594	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104006595	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104006596	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104006597	substrate binding pocket [chemical binding]; other site
425104006598	membrane-bound complex binding site; other site
425104006599	hinge residues; other site
425104006600	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
425104006601	catalytic core [active]
425104006602	Transcriptional regulators [Transcription]; Region: GntR; COG1802
425104006603	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
425104006604	DNA-binding site [nucleotide binding]; DNA binding site
425104006605	FCD domain; Region: FCD; pfam07729
425104006606	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
425104006607	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
425104006608	tetramer interface [polypeptide binding]; other site
425104006609	active site
425104006610	Mg2+/Mn2+ binding site [ion binding]; other site
425104006611	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
425104006612	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
425104006613	dimer interface [polypeptide binding]; other site
425104006614	active site
425104006615	citrylCoA binding site [chemical binding]; other site
425104006616	oxalacetate/citrate binding site [chemical binding]; other site
425104006617	coenzyme A binding site [chemical binding]; other site
425104006618	catalytic triad [active]
425104006619	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
425104006620	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
425104006621	substrate binding site [chemical binding]; other site
425104006622	ligand binding site [chemical binding]; other site
425104006623	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
425104006624	substrate binding site [chemical binding]; other site
425104006625	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
425104006626	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
425104006627	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104006628	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104006629	Walker A/P-loop; other site
425104006630	ATP binding site [chemical binding]; other site
425104006631	ABC transporter signature motif; other site
425104006632	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104006633	Walker B; other site
425104006634	ABC transporter; Region: ABC_tran_2; pfam12848
425104006635	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104006636	Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894
425104006637	multidrug efflux protein; Reviewed; Region: PRK01766
425104006638	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
425104006639	cation binding site [ion binding]; other site
425104006640	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
425104006641	Lumazine binding domain; Region: Lum_binding; pfam00677
425104006642	Lumazine binding domain; Region: Lum_binding; pfam00677
425104006643	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
425104006644	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
425104006645	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
425104006646	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
425104006647	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
425104006648	active site
425104006649	dimer interface [polypeptide binding]; other site
425104006650	motif 1; other site
425104006651	motif 2; other site
425104006652	motif 3; other site
425104006653	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
425104006654	anticodon binding site; other site
425104006655	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
425104006656	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
425104006657	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
425104006658	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
425104006659	23S rRNA binding site [nucleotide binding]; other site
425104006660	L21 binding site [polypeptide binding]; other site
425104006661	L13 binding site [polypeptide binding]; other site
425104006662	thioredoxin reductase; Provisional; Region: PRK10262
425104006663	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
425104006664	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
425104006665	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
425104006666	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
425104006667	hexamer interface [polypeptide binding]; other site
425104006668	ligand binding site [chemical binding]; other site
425104006669	putative active site [active]
425104006670	NAD(P) binding site [chemical binding]; other site
425104006671	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
425104006672	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
425104006673	putative DNA binding site [nucleotide binding]; other site
425104006674	putative Zn2+ binding site [ion binding]; other site
425104006675	AsnC family; Region: AsnC_trans_reg; pfam01037
425104006676	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
425104006677	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
425104006678	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
425104006679	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
425104006680	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
425104006681	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
425104006682	recombination factor protein RarA; Reviewed; Region: PRK13342
425104006683	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104006684	Walker A motif; other site
425104006685	ATP binding site [chemical binding]; other site
425104006686	Walker B motif; other site
425104006687	arginine finger; other site
425104006688	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
425104006689	camphor resistance protein CrcB; Provisional; Region: PRK14197
425104006690	seryl-tRNA synthetase; Provisional; Region: PRK05431
425104006691	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
425104006692	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
425104006693	dimer interface [polypeptide binding]; other site
425104006694	active site
425104006695	motif 1; other site
425104006696	motif 2; other site
425104006697	motif 3; other site
425104006698	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
425104006699	DsrC like protein; Region: DsrC; pfam04358
425104006700	DsrH like protein; Region: DsrH; cl17347
425104006701	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
425104006702	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
425104006703	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
425104006704	YccA-like proteins; Region: YccA_like; cd10433
425104006705	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
425104006706	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104006707	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104006708	dimerization interface [polypeptide binding]; other site
425104006709	putative transporter; Provisional; Region: PRK11043
425104006710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104006711	putative substrate translocation pore; other site
425104006712	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
425104006713	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
425104006714	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104006715	DNA binding residues [nucleotide binding]
425104006716	dimerization interface [polypeptide binding]; other site
425104006717	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
425104006718	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104006719	DNA binding residues [nucleotide binding]
425104006720	dimerization interface [polypeptide binding]; other site
425104006721	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104006722	DNA binding residues [nucleotide binding]
425104006723	dimerization interface [polypeptide binding]; other site
425104006724	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
425104006725	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
425104006726	intersubunit interface [polypeptide binding]; other site
425104006727	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
425104006728	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
425104006729	Walker A/P-loop; other site
425104006730	ATP binding site [chemical binding]; other site
425104006731	Q-loop/lid; other site
425104006732	ABC transporter signature motif; other site
425104006733	Walker B; other site
425104006734	D-loop; other site
425104006735	H-loop/switch region; other site
425104006736	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
425104006737	ABC-2 type transporter; Region: ABC2_membrane; cl17235
425104006738	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104006739	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104006740	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104006741	Protein of unknown function (DUF3374); Region: DUF3374; pfam11854
425104006742	Predicted membrane protein [Function unknown]; Region: COG2259
425104006743	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
425104006744	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
425104006745	NADP binding site [chemical binding]; other site
425104006746	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
425104006747	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
425104006748	Metal-binding active site; metal-binding site
425104006749	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
425104006750	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
425104006751	cobalamin synthase; Reviewed; Region: cobS; PRK00235
425104006752	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
425104006753	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
425104006754	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
425104006755	catalytic triad [active]
425104006756	cobyric acid synthase; Provisional; Region: PRK00784
425104006757	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
425104006758	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
425104006759	catalytic triad [active]
425104006760	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435
425104006761	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
425104006762	catalytic core [active]
425104006763	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
425104006764	homotrimer interface [polypeptide binding]; other site
425104006765	Walker A motif; other site
425104006766	GTP binding site [chemical binding]; other site
425104006767	Walker B motif; other site
425104006768	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
425104006769	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
425104006770	cobalamin binding residues [chemical binding]; other site
425104006771	putative BtuC binding residues; other site
425104006772	dimer interface [polypeptide binding]; other site
425104006773	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
425104006774	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
425104006775	homotrimer interface [polypeptide binding]; other site
425104006776	Walker A motif; other site
425104006777	GTP binding site [chemical binding]; other site
425104006778	Walker B motif; other site
425104006779	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
425104006780	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
425104006781	ABC-ATPase subunit  interface; other site
425104006782	dimer interface [polypeptide binding]; other site
425104006783	putative PBP binding regions; other site
425104006784	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
425104006785	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
425104006786	Walker A/P-loop; other site
425104006787	ATP binding site [chemical binding]; other site
425104006788	Q-loop/lid; other site
425104006789	ABC transporter signature motif; other site
425104006790	Walker B; other site
425104006791	D-loop; other site
425104006792	H-loop/switch region; other site
425104006793	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
425104006794	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104006795	N-terminal plug; other site
425104006796	ligand-binding site [chemical binding]; other site
425104006797	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104006798	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104006799	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104006800	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
425104006801	Nitrogen regulatory protein P-II; Region: P-II; cl00412
425104006802	Nitrogen regulatory protein P-II; Region: P-II; smart00938
425104006803	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
425104006804	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
425104006805	active site
425104006806	DNA binding site [nucleotide binding]
425104006807	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
425104006808	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
425104006809	Catalytic site [active]
425104006810	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
425104006811	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
425104006812	DHHA2 domain; Region: DHHA2; pfam02833
425104006813	acetyl-CoA synthetase; Provisional; Region: PRK04319
425104006814	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
425104006815	active site
425104006816	acyl-activating enzyme (AAE) consensus motif; other site
425104006817	putative CoA binding site [chemical binding]; other site
425104006818	AMP binding site [chemical binding]; other site
425104006819	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
425104006820	tetramer interface [polypeptide binding]; other site
425104006821	TPP-binding site [chemical binding]; other site
425104006822	heterodimer interface [polypeptide binding]; other site
425104006823	phosphorylation loop region [posttranslational modification]
425104006824	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
425104006825	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
425104006826	alpha subunit interface [polypeptide binding]; other site
425104006827	TPP binding site [chemical binding]; other site
425104006828	heterodimer interface [polypeptide binding]; other site
425104006829	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
425104006830	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
425104006831	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
425104006832	E3 interaction surface; other site
425104006833	lipoyl attachment site [posttranslational modification]; other site
425104006834	e3 binding domain; Region: E3_binding; pfam02817
425104006835	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
425104006836	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104006837	Ligand Binding Site [chemical binding]; other site
425104006838	AAA domain; Region: AAA_32; pfam13654
425104006839	lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764
425104006840	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
425104006841	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
425104006842	PAS fold; Region: PAS_4; pfam08448
425104006843	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104006844	putative active site [active]
425104006845	heme pocket [chemical binding]; other site
425104006846	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104006847	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104006848	metal binding site [ion binding]; metal-binding site
425104006849	active site
425104006850	I-site; other site
425104006851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104006852	NAD(P) binding site [chemical binding]; other site
425104006853	active site
425104006854	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
425104006855	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
425104006856	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
425104006857	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
425104006858	SnoaL-like domain; Region: SnoaL_4; pfam13577
425104006859	Predicted transcriptional regulators [Transcription]; Region: COG1733
425104006860	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
425104006861	Domain of unknown function DUF87; Region: DUF87; pfam01935
425104006862	virion protein; Provisional; Region: V; PHA02564
425104006863	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
425104006864	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
425104006865	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
425104006866	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
425104006867	Int/Topo IB signature motif; other site
425104006868	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
425104006869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
425104006870	active site
425104006871	phosphorylation site [posttranslational modification]
425104006872	intermolecular recognition site; other site
425104006873	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
425104006874	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104006875	Zn2+ binding site [ion binding]; other site
425104006876	Mg2+ binding site [ion binding]; other site
425104006877	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
425104006878	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
425104006879	Low-spin heme binding site [chemical binding]; other site
425104006880	Putative water exit pathway; other site
425104006881	Binuclear center (active site) [active]
425104006882	Putative proton exit pathway; other site
425104006883	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
425104006884	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
425104006885	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
425104006886	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
425104006887	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
425104006888	Cytochrome c; Region: Cytochrom_C; pfam00034
425104006889	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
425104006890	FixH; Region: FixH; pfam05751
425104006891	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
425104006892	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
425104006893	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
425104006894	metal-binding site [ion binding]
425104006895	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
425104006896	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
425104006897	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
425104006898	Family description; Region: DsbD_2; pfam13386
425104006899	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
425104006900	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
425104006901	ligand binding site [chemical binding]; other site
425104006902	flexible hinge region; other site
425104006903	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
425104006904	putative switch regulator; other site
425104006905	non-specific DNA interactions [nucleotide binding]; other site
425104006906	DNA binding site [nucleotide binding]
425104006907	sequence specific DNA binding site [nucleotide binding]; other site
425104006908	putative cAMP binding site [chemical binding]; other site
425104006909	universal stress protein UspE; Provisional; Region: PRK11175
425104006910	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104006911	Ligand Binding Site [chemical binding]; other site
425104006912	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104006913	Ligand Binding Site [chemical binding]; other site
425104006914	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
425104006915	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
425104006916	Ligand Binding Site [chemical binding]; other site
425104006917	Protein of unknown function (DUF2987); Region: DUF2987; pfam11205
425104006918	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
425104006919	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
425104006920	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
425104006921	phosphate binding site [ion binding]; other site
425104006922	putative substrate binding pocket [chemical binding]; other site
425104006923	dimer interface [polypeptide binding]; other site
425104006924	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
425104006925	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
425104006926	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104006927	homodimer interface [polypeptide binding]; other site
425104006928	catalytic residue [active]
425104006929	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
425104006930	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
425104006931	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
425104006932	Protein of unknown function (DUF2989); Region: DUF2989; pfam11207
425104006933	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
425104006934	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
425104006935	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
425104006936	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104006937	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104006938	substrate binding pocket [chemical binding]; other site
425104006939	membrane-bound complex binding site; other site
425104006940	hinge residues; other site
425104006941	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104006942	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104006943	metal binding site [ion binding]; metal-binding site
425104006944	active site
425104006945	I-site; other site
425104006946	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
425104006947	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
425104006948	heme binding site [chemical binding]; other site
425104006949	ferroxidase pore; other site
425104006950	ferroxidase diiron center [ion binding]; other site
425104006951	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
425104006952	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
425104006953	heme binding site [chemical binding]; other site
425104006954	ferroxidase pore; other site
425104006955	ferroxidase diiron center [ion binding]; other site
425104006956	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
425104006957	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
425104006958	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
425104006959	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104006960	Coenzyme A binding pocket [chemical binding]; other site
425104006961	Nudix hydrolase homolog; Region: PLN02791
425104006962	C factor cell-cell signaling protein; Provisional; Region: PRK09009
425104006963	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
425104006964	NADP binding site [chemical binding]; other site
425104006965	homodimer interface [polypeptide binding]; other site
425104006966	active site
425104006967	Ecdysteroid kinase; Region: EcKinase; cl17738
425104006968	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
425104006969	active site
425104006970	DNA binding site [nucleotide binding]
425104006971	Int/Topo IB signature motif; other site
425104006972	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
425104006973	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
425104006974	active site
425104006975	Phosphotransferase enzyme family; Region: APH; pfam01636
425104006976	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
425104006977	active site
425104006978	ATP binding site [chemical binding]; other site
425104006979	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
425104006980	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
425104006981	inhibitor-cofactor binding pocket; inhibition site
425104006982	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104006983	catalytic residue [active]
425104006984	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
425104006985	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104006986	N-terminal plug; other site
425104006987	ligand-binding site [chemical binding]; other site
425104006988	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104006989	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
425104006990	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
425104006991	active site
425104006992	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
425104006993	heme-binding site [chemical binding]; other site
425104006994	Patatin-like phospholipase; Region: Patatin; pfam01734
425104006995	nucleophile elbow; other site
425104006996	PAS domain S-box; Region: sensory_box; TIGR00229
425104006997	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104006998	putative active site [active]
425104006999	heme pocket [chemical binding]; other site
425104007000	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104007001	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104007002	metal binding site [ion binding]; metal-binding site
425104007003	active site
425104007004	I-site; other site
425104007005	Part of AAA domain; Region: AAA_19; pfam13245
425104007006	Family description; Region: UvrD_C_2; pfam13538
425104007007	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
425104007008	amidase catalytic site [active]
425104007009	Zn binding residues [ion binding]; other site
425104007010	substrate binding site [chemical binding]; other site
425104007011	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
425104007012	putative binding surface; other site
425104007013	active site
425104007014	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104007015	Zn2+ binding site [ion binding]; other site
425104007016	Mg2+ binding site [ion binding]; other site
425104007017	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104007018	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104007019	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104007020	dimerization interface [polypeptide binding]; other site
425104007021	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
425104007022	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
425104007023	GDP-binding site [chemical binding]; other site
425104007024	ACT binding site; other site
425104007025	IMP binding site; other site
425104007026	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
425104007027	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
425104007028	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
425104007029	active site residue [active]
425104007030	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607
425104007031	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
425104007032	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
425104007033	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
425104007034	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
425104007035	acyl-activating enzyme (AAE) consensus motif; other site
425104007036	putative AMP binding site [chemical binding]; other site
425104007037	putative active site [active]
425104007038	putative CoA binding site [chemical binding]; other site
425104007039	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
425104007040	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
425104007041	active site
425104007042	Methyltransferase domain; Region: Methyltransf_23; pfam13489
425104007043	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104007044	S-adenosylmethionine binding site [chemical binding]; other site
425104007045	Protein of unknown function DUF262; Region: DUF262; pfam03235
425104007046	Uncharacterized conserved protein [Function unknown]; Region: COG1479
425104007047	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
425104007048	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
425104007049	Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413
425104007050	active site
425104007051	metal binding site [ion binding]; metal-binding site
425104007052	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
425104007053	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
425104007054	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
425104007055	dimer interface [polypeptide binding]; other site
425104007056	PYR/PP interface [polypeptide binding]; other site
425104007057	TPP binding site [chemical binding]; other site
425104007058	substrate binding site [chemical binding]; other site
425104007059	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
425104007060	Domain of unknown function; Region: EKR; smart00890
425104007061	4Fe-4S binding domain; Region: Fer4_6; pfam12837
425104007062	4Fe-4S binding domain; Region: Fer4; pfam00037
425104007063	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
425104007064	TPP-binding site [chemical binding]; other site
425104007065	dimer interface [polypeptide binding]; other site
425104007066	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
425104007067	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
425104007068	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
425104007069	4Fe-4S binding domain; Region: Fer4; pfam00037
425104007070	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
425104007071	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
425104007072	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
425104007073	NADH:ubiquinone oxidoreductase, Na(+)-translocating, F subunit; Region: nqrF; TIGR01941
425104007074	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
425104007075	catalytic loop [active]
425104007076	iron binding site [ion binding]; other site
425104007077	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
425104007078	FAD binding pocket [chemical binding]; other site
425104007079	FAD binding motif [chemical binding]; other site
425104007080	phosphate binding motif [ion binding]; other site
425104007081	beta-alpha-beta structure motif; other site
425104007082	NAD binding pocket [chemical binding]; other site
425104007083	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
425104007084	trimer interface [polypeptide binding]; other site
425104007085	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
425104007086	eyelet of channel; other site
425104007087	FMN-binding domain; Region: FMN_bind; pfam04205
425104007088	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
425104007089	ApbE family; Region: ApbE; pfam02424
425104007090	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
425104007091	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104007092	dimer interface [polypeptide binding]; other site
425104007093	phosphorylation site [posttranslational modification]
425104007094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104007095	ATP binding site [chemical binding]; other site
425104007096	Mg2+ binding site [ion binding]; other site
425104007097	G-X-G motif; other site
425104007098	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
425104007099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104007100	active site
425104007101	phosphorylation site [posttranslational modification]
425104007102	intermolecular recognition site; other site
425104007103	dimerization interface [polypeptide binding]; other site
425104007104	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104007105	DNA binding residues [nucleotide binding]
425104007106	dimerization interface [polypeptide binding]; other site
425104007107	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
425104007108	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
425104007109	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104007110	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104007111	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104007112	Uncharacterized conserved protein [Function unknown]; Region: COG3148
425104007113	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
425104007114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104007115	putative substrate translocation pore; other site
425104007116	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
425104007117	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
425104007118	domain interface [polypeptide binding]; other site
425104007119	putative active site [active]
425104007120	catalytic site [active]
425104007121	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
425104007122	domain interface [polypeptide binding]; other site
425104007123	putative active site [active]
425104007124	catalytic site [active]
425104007125	Domain of unknown function (DUF1904); Region: DUF1904; pfam08921
425104007126	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
425104007127	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
425104007128	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
425104007129	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
425104007130	active site
425104007131	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
425104007132	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
425104007133	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
425104007134	active site
425104007135	dimer interface [polypeptide binding]; other site
425104007136	tetratricopeptide repeat protein; Provisional; Region: PRK11788
425104007137	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104007138	binding surface
425104007139	TPR motif; other site
425104007140	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
425104007141	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
425104007142	IHF dimer interface [polypeptide binding]; other site
425104007143	IHF - DNA interface [nucleotide binding]; other site
425104007144	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
425104007145	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
425104007146	RNA binding site [nucleotide binding]; other site
425104007147	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
425104007148	RNA binding site [nucleotide binding]; other site
425104007149	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
425104007150	RNA binding site [nucleotide binding]; other site
425104007151	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
425104007152	RNA binding site [nucleotide binding]; other site
425104007153	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
425104007154	RNA binding site [nucleotide binding]; other site
425104007155	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
425104007156	RNA binding site [nucleotide binding]; other site
425104007157	cytidylate kinase; Provisional; Region: cmk; PRK00023
425104007158	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
425104007159	CMP-binding site; other site
425104007160	The sites determining sugar specificity; other site
425104007161	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
425104007162	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
425104007163	hinge; other site
425104007164	active site
425104007165	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
425104007166	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
425104007167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104007168	homodimer interface [polypeptide binding]; other site
425104007169	catalytic residue [active]
425104007170	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
425104007171	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
425104007172	catalytic residue [active]
425104007173	DNA gyrase subunit A; Validated; Region: PRK05560
425104007174	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
425104007175	CAP-like domain; other site
425104007176	active site
425104007177	primary dimer interface [polypeptide binding]; other site
425104007178	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
425104007179	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
425104007180	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
425104007181	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
425104007182	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
425104007183	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
425104007184	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
425104007185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104007186	S-adenosylmethionine binding site [chemical binding]; other site
425104007187	phosphoglycolate phosphatase; Provisional; Region: PRK13222
425104007188	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104007189	motif II; other site
425104007190	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
425104007191	ATP cone domain; Region: ATP-cone; pfam03477
425104007192	Class I ribonucleotide reductase; Region: RNR_I; cd01679
425104007193	active site
425104007194	dimer interface [polypeptide binding]; other site
425104007195	catalytic residues [active]
425104007196	effector binding site; other site
425104007197	R2 peptide binding site; other site
425104007198	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
425104007199	dimer interface [polypeptide binding]; other site
425104007200	putative radical transfer pathway; other site
425104007201	diiron center [ion binding]; other site
425104007202	tyrosyl radical; other site
425104007203	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
425104007204	catalytic loop [active]
425104007205	iron binding site [ion binding]; other site
425104007206	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104007207	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
425104007208	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104007209	dimer interface [polypeptide binding]; other site
425104007210	putative CheW interface [polypeptide binding]; other site
425104007211	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
425104007212	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
425104007213	active site
425104007214	FMN binding site [chemical binding]; other site
425104007215	2,4-decadienoyl-CoA binding site; other site
425104007216	catalytic residue [active]
425104007217	4Fe-4S cluster binding site [ion binding]; other site
425104007218	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
425104007219	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
425104007220	protease 4; Provisional; Region: PRK10949
425104007221	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
425104007222	tandem repeat interface [polypeptide binding]; other site
425104007223	oligomer interface [polypeptide binding]; other site
425104007224	active site residues [active]
425104007225	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
425104007226	tandem repeat interface [polypeptide binding]; other site
425104007227	oligomer interface [polypeptide binding]; other site
425104007228	active site residues [active]
425104007229	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
425104007230	active site
425104007231	homodimer interface [polypeptide binding]; other site
425104007232	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
425104007233	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
425104007234	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
425104007235	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
425104007236	putative active site [active]
425104007237	Zn binding site [ion binding]; other site
425104007238	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
425104007239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104007240	active site
425104007241	phosphorylation site [posttranslational modification]
425104007242	intermolecular recognition site; other site
425104007243	dimerization interface [polypeptide binding]; other site
425104007244	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104007245	DNA binding site [nucleotide binding]
425104007246	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
425104007247	DEAD-like helicases superfamily; Region: DEXDc; smart00487
425104007248	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104007249	ATP binding site [chemical binding]; other site
425104007250	putative Mg++ binding site [ion binding]; other site
425104007251	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104007252	nucleotide binding region [chemical binding]; other site
425104007253	ATP-binding site [chemical binding]; other site
425104007254	hypothetical protein; Provisional; Region: PRK05421
425104007255	putative catalytic site [active]
425104007256	putative phosphate binding site [ion binding]; other site
425104007257	putative metal binding site [ion binding]; other site
425104007258	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
425104007259	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
425104007260	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
425104007261	putative active site [active]
425104007262	catalytic site [active]
425104007263	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
425104007264	putative active site [active]
425104007265	catalytic site [active]
425104007266	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
425104007267	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
425104007268	ligand binding site [chemical binding]; other site
425104007269	flexible hinge region; other site
425104007270	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
425104007271	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
425104007272	metal binding triad; other site
425104007273	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
425104007274	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
425104007275	active site
425104007276	catalytic site [active]
425104007277	substrate binding site [chemical binding]; other site
425104007278	BCCT family transporter; Region: BCCT; pfam02028
425104007279	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
425104007280	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104007281	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
425104007282	Nitrate and nitrite sensing; Region: NIT; pfam08376
425104007283	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104007284	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104007285	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104007286	dimer interface [polypeptide binding]; other site
425104007287	putative CheW interface [polypeptide binding]; other site
425104007288	quinolinate synthetase; Provisional; Region: PRK09375
425104007289	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
425104007290	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
425104007291	E3 interaction surface; other site
425104007292	lipoyl attachment site [posttranslational modification]; other site
425104007293	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
425104007294	E3 interaction surface; other site
425104007295	lipoyl attachment site [posttranslational modification]; other site
425104007296	e3 binding domain; Region: E3_binding; pfam02817
425104007297	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
425104007298	3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182
425104007299	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
425104007300	alpha subunit interface [polypeptide binding]; other site
425104007301	TPP binding site [chemical binding]; other site
425104007302	heterodimer interface [polypeptide binding]; other site
425104007303	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
425104007304	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
425104007305	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
425104007306	tetramer interface [polypeptide binding]; other site
425104007307	TPP-binding site [chemical binding]; other site
425104007308	heterodimer interface [polypeptide binding]; other site
425104007309	phosphorylation loop region [posttranslational modification]
425104007310	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
425104007311	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
425104007312	putative active site [active]
425104007313	Zn binding site [ion binding]; other site
425104007314	methionine sulfoxide reductase A; Provisional; Region: PRK14054
425104007315	phosphoglucomutase; Validated; Region: PRK07564
425104007316	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
425104007317	active site
425104007318	substrate binding site [chemical binding]; other site
425104007319	metal binding site [ion binding]; metal-binding site
425104007320	replication initiation regulator SeqA; Provisional; Region: PRK11187
425104007321	PGAP1-like protein; Region: PGAP1; pfam07819
425104007322	acyl-CoA esterase; Provisional; Region: PRK10673
425104007323	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
425104007324	LexA regulated protein; Provisional; Region: PRK11675
425104007325	flavodoxin FldA; Validated; Region: PRK09267
425104007326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
425104007327	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
425104007328	elongation factor P; Validated; Region: PRK00529
425104007329	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
425104007330	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
425104007331	RNA binding site [nucleotide binding]; other site
425104007332	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
425104007333	RNA binding site [nucleotide binding]; other site
425104007334	aminotransferase AlaT; Validated; Region: PRK09265
425104007335	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
425104007336	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104007337	homodimer interface [polypeptide binding]; other site
425104007338	catalytic residue [active]
425104007339	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
425104007340	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
425104007341	dimer interface [polypeptide binding]; other site
425104007342	active site
425104007343	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
425104007344	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
425104007345	metal ion-dependent adhesion site (MIDAS); other site
425104007346	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
425104007347	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
425104007348	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104007349	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
425104007350	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104007351	5'-nucleotidase; Provisional; Region: PRK03826
425104007352	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
425104007353	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104007354	Zn2+ binding site [ion binding]; other site
425104007355	Mg2+ binding site [ion binding]; other site
425104007356	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
425104007357	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
425104007358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104007359	S-adenosylmethionine binding site [chemical binding]; other site
425104007360	hypothetical protein; Provisional; Region: PRK11111
425104007361	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
425104007362	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
425104007363	putative catalytic cysteine [active]
425104007364	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
425104007365	putative active site [active]
425104007366	metal binding site [ion binding]; metal-binding site
425104007367	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
425104007368	malate synthase G; Provisional; Region: PRK02999
425104007369	active site
425104007370	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104007371	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104007372	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
425104007373	substrate binding pocket [chemical binding]; other site
425104007374	dimerization interface [polypeptide binding]; other site
425104007375	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
425104007376	tetramer interface [polypeptide binding]; other site
425104007377	active site
425104007378	Mg2+/Mn2+ binding site [ion binding]; other site
425104007379	isocitrate lyase; Region: PLN02892
425104007380	dUMP phosphatase; Provisional; Region: PRK09449
425104007381	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104007382	motif II; other site
425104007383	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
425104007384	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
425104007385	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
425104007386	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104007387	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
425104007388	Fumarase C-terminus; Region: Fumerase_C; pfam05683
425104007389	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
425104007390	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
425104007391	chorismate binding enzyme; Region: Chorismate_bind; cl10555
425104007392	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
425104007393	putative active site [active]
425104007394	putative CoA binding site [chemical binding]; other site
425104007395	nudix motif; other site
425104007396	metal binding site [ion binding]; metal-binding site
425104007397	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
425104007398	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
425104007399	putative dimer interface [polypeptide binding]; other site
425104007400	putative anticodon binding site; other site
425104007401	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
425104007402	homodimer interface [polypeptide binding]; other site
425104007403	motif 1; other site
425104007404	motif 2; other site
425104007405	active site
425104007406	motif 3; other site
425104007407	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104007408	TPR motif; other site
425104007409	binding surface
425104007410	TPR repeat; Region: TPR_11; pfam13414
425104007411	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104007412	binding surface
425104007413	TPR motif; other site
425104007414	TPR repeat; Region: TPR_11; pfam13414
425104007415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104007416	binding surface
425104007417	TPR motif; other site
425104007418	TPR repeat; Region: TPR_11; pfam13414
425104007419	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
425104007420	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
425104007421	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
425104007422	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
425104007423	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
425104007424	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
425104007425	ATP binding site [chemical binding]; other site
425104007426	Walker A motif; other site
425104007427	hexamer interface [polypeptide binding]; other site
425104007428	Walker B motif; other site
425104007429	AAA domain; Region: AAA_31; pfam13614
425104007430	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
425104007431	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
425104007432	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
425104007433	TadE-like protein; Region: TadE; pfam07811
425104007434	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
425104007435	TadE-like protein; Region: TadE; pfam07811
425104007436	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
425104007437	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
425104007438	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
425104007439	BON domain; Region: BON; pfam04972
425104007440	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
425104007441	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
425104007442	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
425104007443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104007444	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
425104007445	Walker A motif; other site
425104007446	ATP binding site [chemical binding]; other site
425104007447	Walker B motif; other site
425104007448	arginine finger; other site
425104007449	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
425104007450	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
425104007451	Homeodomain-like domain; Region: HTH_23; pfam13384
425104007452	Winged helix-turn helix; Region: HTH_29; pfam13551
425104007453	Homeodomain-like domain; Region: HTH_32; pfam13565
425104007454	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
425104007455	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
425104007456	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
425104007457	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
425104007458	Sulfatase; Region: Sulfatase; cl17466
425104007459	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104007460	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104007461	metal binding site [ion binding]; metal-binding site
425104007462	active site
425104007463	I-site; other site
425104007464	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
425104007465	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
425104007466	Ligand binding site; other site
425104007467	Putative Catalytic site; other site
425104007468	DXD motif; other site
425104007469	Methyltransferase domain; Region: Methyltransf_23; pfam13489
425104007470	Methyltransferase domain; Region: Methyltransf_11; pfam08241
425104007471	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
425104007472	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104007473	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
425104007474	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
425104007475	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
425104007476	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104007477	ATP binding site [chemical binding]; other site
425104007478	putative Mg++ binding site [ion binding]; other site
425104007479	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104007480	nucleotide binding region [chemical binding]; other site
425104007481	ATP-binding site [chemical binding]; other site
425104007482	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
425104007483	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
425104007484	GAF domain; Region: GAF; pfam01590
425104007485	PAS domain; Region: PAS_9; pfam13426
425104007486	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104007487	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104007488	metal binding site [ion binding]; metal-binding site
425104007489	active site
425104007490	I-site; other site
425104007491	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104007492	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
425104007493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104007494	S-adenosylmethionine binding site [chemical binding]; other site
425104007495	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
425104007496	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
425104007497	ATP binding site [chemical binding]; other site
425104007498	Mg++ binding site [ion binding]; other site
425104007499	motif III; other site
425104007500	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104007501	nucleotide binding region [chemical binding]; other site
425104007502	ATP-binding site [chemical binding]; other site
425104007503	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104007504	dimerization interface [polypeptide binding]; other site
425104007505	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104007506	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104007507	metal binding site [ion binding]; metal-binding site
425104007508	active site
425104007509	I-site; other site
425104007510	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104007511	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
425104007512	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
425104007513	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104007514	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
425104007515	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
425104007516	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
425104007517	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
425104007518	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
425104007519	putative active site [active]
425104007520	Zn binding site [ion binding]; other site
425104007521	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
425104007522	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
425104007523	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104007524	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
425104007525	dimerization interface [polypeptide binding]; other site
425104007526	substrate binding pocket [chemical binding]; other site
425104007527	agmatine deiminase; Provisional; Region: PRK13551
425104007528	agmatine deiminase; Region: agmatine_aguA; TIGR03380
425104007529	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
425104007530	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
425104007531	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
425104007532	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
425104007533	putative active site; other site
425104007534	catalytic triad [active]
425104007535	putative dimer interface [polypeptide binding]; other site
425104007536	Uncharacterized conserved protein [Function unknown]; Region: COG2850
425104007537	Cupin-like domain; Region: Cupin_8; pfam13621
425104007538	elongation factor G; Reviewed; Region: PRK00007
425104007539	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
425104007540	G1 box; other site
425104007541	putative GEF interaction site [polypeptide binding]; other site
425104007542	GTP/Mg2+ binding site [chemical binding]; other site
425104007543	Switch I region; other site
425104007544	G2 box; other site
425104007545	G3 box; other site
425104007546	Switch II region; other site
425104007547	G4 box; other site
425104007548	G5 box; other site
425104007549	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
425104007550	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
425104007551	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
425104007552	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
425104007553	active site
425104007554	catalytic site [active]
425104007555	substrate binding site [chemical binding]; other site
425104007556	Protein of unknown function (DUF3334); Region: DUF3334; pfam11813
425104007557	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
425104007558	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104007559	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104007560	dimerization interface [polypeptide binding]; other site
425104007561	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104007562	dimer interface [polypeptide binding]; other site
425104007563	putative CheW interface [polypeptide binding]; other site
425104007564	Uncharacterized conserved protein [Function unknown]; Region: COG3603
425104007565	Family description; Region: ACT_7; pfam13840
425104007566	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
425104007567	dimerization domain swap beta strand [polypeptide binding]; other site
425104007568	regulatory protein interface [polypeptide binding]; other site
425104007569	active site
425104007570	regulatory phosphorylation site [posttranslational modification]; other site
425104007571	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
425104007572	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
425104007573	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
425104007574	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
425104007575	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
425104007576	HPr interaction site; other site
425104007577	glycerol kinase (GK) interaction site [polypeptide binding]; other site
425104007578	active site
425104007579	phosphorylation site [posttranslational modification]
425104007580	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
425104007581	ArsC family; Region: ArsC; pfam03960
425104007582	putative catalytic residues [active]
425104007583	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
425104007584	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
425104007585	metal binding site [ion binding]; metal-binding site
425104007586	dimer interface [polypeptide binding]; other site
425104007587	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
425104007588	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
425104007589	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
425104007590	active site clefts [active]
425104007591	zinc binding site [ion binding]; other site
425104007592	dimer interface [polypeptide binding]; other site
425104007593	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
425104007594	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
425104007595	inhibitor-cofactor binding pocket; inhibition site
425104007596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104007597	catalytic residue [active]
425104007598	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
425104007599	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
425104007600	active site
425104007601	NAD binding site [chemical binding]; other site
425104007602	metal binding site [ion binding]; metal-binding site
425104007603	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
425104007604	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
425104007605	Ligand binding site; other site
425104007606	oligomer interface; other site
425104007607	Protein of unknown function (DUF2897); Region: DUF2897; pfam11446
425104007608	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
425104007609	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104007610	Protein export membrane protein; Region: SecD_SecF; cl14618
425104007611	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104007612	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104007613	lipoprotein; Provisional; Region: PRK11679
425104007614	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
425104007615	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
425104007616	dihydrodipicolinate synthase; Region: dapA; TIGR00674
425104007617	dimer interface [polypeptide binding]; other site
425104007618	active site
425104007619	catalytic residue [active]
425104007620	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
425104007621	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
425104007622	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
425104007623	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
425104007624	catalytic triad [active]
425104007625	Lysine efflux permease [General function prediction only]; Region: COG1279
425104007626	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
425104007627	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104007628	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
425104007629	putative dimerization interface [polypeptide binding]; other site
425104007630	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
425104007631	Domain of unknown function DUF20; Region: UPF0118; pfam01594
425104007632	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
425104007633	CPxP  motif; other site
425104007634	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
425104007635	Peptidase family M48; Region: Peptidase_M48; cl12018
425104007636	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
425104007637	ArsC family; Region: ArsC; pfam03960
425104007638	catalytic residues [active]
425104007639	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
425104007640	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
425104007641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104007642	Walker A motif; other site
425104007643	ATP binding site [chemical binding]; other site
425104007644	Walker B motif; other site
425104007645	arginine finger; other site
425104007646	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
425104007647	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
425104007648	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
425104007649	putative GSH binding site [chemical binding]; other site
425104007650	catalytic residues [active]
425104007651	superoxide dismutase; Provisional; Region: PRK10543
425104007652	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
425104007653	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
425104007654	PrkA family serine protein kinase; Provisional; Region: PRK15455
425104007655	AAA ATPase domain; Region: AAA_16; pfam13191
425104007656	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
425104007657	hypothetical protein; Provisional; Region: PRK05325
425104007658	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
425104007659	SpoVR family protein; Provisional; Region: PRK11767
425104007660	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
425104007661	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
425104007662	5S rRNA interface [nucleotide binding]; other site
425104007663	CTC domain interface [polypeptide binding]; other site
425104007664	L16 interface [polypeptide binding]; other site
425104007665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
425104007666	Peptidase M15; Region: Peptidase_M15_3; cl01194
425104007667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
425104007668	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
425104007669	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
425104007670	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
425104007671	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
425104007672	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
425104007673	GIY-YIG motif/motif A; other site
425104007674	active site
425104007675	catalytic site [active]
425104007676	putative DNA binding site [nucleotide binding]; other site
425104007677	metal binding site [ion binding]; metal-binding site
425104007678	UvrB/uvrC motif; Region: UVR; pfam02151
425104007679	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
425104007680	response regulator; Provisional; Region: PRK09483
425104007681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104007682	active site
425104007683	phosphorylation site [posttranslational modification]
425104007684	intermolecular recognition site; other site
425104007685	dimerization interface [polypeptide binding]; other site
425104007686	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104007687	DNA binding residues [nucleotide binding]
425104007688	dimerization interface [polypeptide binding]; other site
425104007689	Uncharacterized conserved protein [Function unknown]; Region: COG3791
425104007690	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
425104007691	dimerization interface [polypeptide binding]; other site
425104007692	DNA binding residues [nucleotide binding]
425104007693	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
425104007694	Transposase; Region: HTH_Tnp_1; pfam01527
425104007695	HTH-like domain; Region: HTH_21; pfam13276
425104007696	Integrase core domain; Region: rve; pfam00665
425104007697	Integrase core domain; Region: rve_2; pfam13333
425104007698	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
425104007699	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
425104007700	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
425104007701	active site
425104007702	DNA binding site [nucleotide binding]
425104007703	Int/Topo IB signature motif; other site
425104007704	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
425104007705	active site
425104007706	DNA binding site [nucleotide binding]
425104007707	Int/Topo IB signature motif; other site
425104007708	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
425104007709	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
425104007710	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
425104007711	active site 1 [active]
425104007712	dimer interface [polypeptide binding]; other site
425104007713	active site 2 [active]
425104007714	ribosome modulation factor; Provisional; Region: PRK14563
425104007715	Protein of unknown function (DUF3466); Region: DUF3466; pfam11949
425104007716	ABC transporter ATPase component; Reviewed; Region: PRK11147
425104007717	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104007718	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104007719	ABC transporter; Region: ABC_tran_2; pfam12848
425104007720	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104007721	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
425104007722	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
425104007723	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
425104007724	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
425104007725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104007726	S-adenosylmethionine binding site [chemical binding]; other site
425104007727	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
425104007728	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
425104007729	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
425104007730	quinone interaction residues [chemical binding]; other site
425104007731	active site
425104007732	catalytic residues [active]
425104007733	FMN binding site [chemical binding]; other site
425104007734	substrate binding site [chemical binding]; other site
425104007735	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
425104007736	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
425104007737	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
425104007738	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
425104007739	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
425104007740	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
425104007741	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
425104007742	aminopeptidase N; Provisional; Region: pepN; PRK14015
425104007743	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
425104007744	active site
425104007745	Zn binding site [ion binding]; other site
425104007746	carboxy-terminal protease; Provisional; Region: PRK11186
425104007747	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
425104007748	protein binding site [polypeptide binding]; other site
425104007749	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
425104007750	Catalytic dyad [active]
425104007751	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
425104007752	ProP expression regulator; Provisional; Region: PRK04950
425104007753	ProQ/FINO family; Region: ProQ; smart00945
425104007754	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
425104007755	YebG protein; Region: YebG; pfam07130
425104007756	Paraquat-inducible protein A; Region: PqiA; pfam04403
425104007757	Paraquat-inducible protein A; Region: PqiA; pfam04403
425104007758	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
425104007759	mce related protein; Region: MCE; pfam02470
425104007760	mce related protein; Region: MCE; pfam02470
425104007761	mce related protein; Region: MCE; pfam02470
425104007762	mce related protein; Region: MCE; pfam02470
425104007763	mce related protein; Region: MCE; pfam02470
425104007764	mce related protein; Region: MCE; pfam02470
425104007765	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104007766	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104007767	metal binding site [ion binding]; metal-binding site
425104007768	active site
425104007769	I-site; other site
425104007770	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
425104007771	active site
425104007772	catalytic site [active]
425104007773	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
425104007774	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
425104007775	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
425104007776	metal ion-dependent adhesion site (MIDAS); other site
425104007777	proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789
425104007778	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
425104007779	ligand binding site [chemical binding]; other site
425104007780	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
425104007781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104007782	active site
425104007783	phosphorylation site [posttranslational modification]
425104007784	intermolecular recognition site; other site
425104007785	dimerization interface [polypeptide binding]; other site
425104007786	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104007787	DNA binding site [nucleotide binding]
425104007788	proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785
425104007789	DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622
425104007790	putative ligand binding site [chemical binding]; other site
425104007791	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104007792	dimer interface [polypeptide binding]; other site
425104007793	phosphorylation site [posttranslational modification]
425104007794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104007795	ATP binding site [chemical binding]; other site
425104007796	Mg2+ binding site [ion binding]; other site
425104007797	G-X-G motif; other site
425104007798	cystathionine beta-lyase; Provisional; Region: PRK09028
425104007799	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
425104007800	homodimer interface [polypeptide binding]; other site
425104007801	substrate-cofactor binding pocket; other site
425104007802	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104007803	catalytic residue [active]
425104007804	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
425104007805	catalytic triad [active]
425104007806	active site nucleophile [active]
425104007807	Beta-lactamase; Region: Beta-lactamase; pfam00144
425104007808	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
425104007809	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
425104007810	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
425104007811	Peptidase family U32; Region: Peptidase_U32; pfam01136
425104007812	Collagenase; Region: DUF3656; pfam12392
425104007813	Peptidase family U32; Region: Peptidase_U32; cl03113
425104007814	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104007815	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104007816	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104007817	putative effector binding pocket; other site
425104007818	dimerization interface [polypeptide binding]; other site
425104007819	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
425104007820	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
425104007821	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
425104007822	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
425104007823	catalytic nucleophile [active]
425104007824	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
425104007825	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
425104007826	Family of unknown function (DUF490); Region: DUF490; pfam04357
425104007827	fatty acid metabolism regulator; Provisional; Region: PRK04984
425104007828	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
425104007829	DNA-binding site [nucleotide binding]; DNA binding site
425104007830	FadR C-terminal domain; Region: FadR_C; pfam07840
425104007831	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
425104007832	disulfide bond formation protein B; Provisional; Region: PRK01749
425104007833	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
425104007834	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
425104007835	active site
425104007836	hypothetical protein; Provisional; Region: PRK05170
425104007837	Transglycosylase SLT domain; Region: SLT_2; pfam13406
425104007838	murein hydrolase B; Provisional; Region: PRK10760; cl17906
425104007839	YcgL domain; Region: YcgL; pfam05166
425104007840	septum formation inhibitor; Reviewed; Region: minC; PRK04804
425104007841	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
425104007842	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
425104007843	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
425104007844	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
425104007845	Switch I; other site
425104007846	Switch II; other site
425104007847	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
425104007848	ribonuclease D; Provisional; Region: PRK10829
425104007849	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
425104007850	catalytic site [active]
425104007851	putative active site [active]
425104007852	putative substrate binding site [chemical binding]; other site
425104007853	HRDC domain; Region: HRDC; pfam00570
425104007854	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
425104007855	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
425104007856	acyl-activating enzyme (AAE) consensus motif; other site
425104007857	putative AMP binding site [chemical binding]; other site
425104007858	putative active site [active]
425104007859	putative CoA binding site [chemical binding]; other site
425104007860	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
425104007861	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
425104007862	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
425104007863	Predicted methyltransferase [General function prediction only]; Region: COG4798
425104007864	Methyltransferase domain; Region: Methyltransf_23; pfam13489
425104007865	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
425104007866	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
425104007867	Glycoprotease family; Region: Peptidase_M22; pfam00814
425104007868	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
425104007869	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
425104007870	catalytic triad [active]
425104007871	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
425104007872	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
425104007873	putative active site [active]
425104007874	metal binding site [ion binding]; metal-binding site
425104007875	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
425104007876	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
425104007877	NAD(P) binding site [chemical binding]; other site
425104007878	catalytic residues [active]
425104007879	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
425104007880	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
425104007881	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
425104007882	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104007883	NAD(P) binding site [chemical binding]; other site
425104007884	active site
425104007885	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
425104007886	DEAD/DEAH box helicase; Region: DEAD; pfam00270
425104007887	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
425104007888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
425104007889	YheO-like PAS domain; Region: PAS_6; pfam08348
425104007890	HTH domain; Region: HTH_22; pfam13309
425104007891	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
425104007892	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
425104007893	homotrimer interaction site [polypeptide binding]; other site
425104007894	putative active site [active]
425104007895	AzlC protein; Region: AzlC; pfam03591
425104007896	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
425104007897	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
425104007898	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
425104007899	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
425104007900	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
425104007901	histidinol dehydrogenase; Region: hisD; TIGR00069
425104007902	NAD binding site [chemical binding]; other site
425104007903	dimerization interface [polypeptide binding]; other site
425104007904	product binding site; other site
425104007905	substrate binding site [chemical binding]; other site
425104007906	zinc binding site [ion binding]; other site
425104007907	catalytic residues [active]
425104007908	histidinol-phosphate aminotransferase; Provisional; Region: PRK04635
425104007909	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
425104007910	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104007911	homodimer interface [polypeptide binding]; other site
425104007912	catalytic residue [active]
425104007913	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
425104007914	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104007915	active site
425104007916	motif I; other site
425104007917	motif II; other site
425104007918	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
425104007919	putative active site pocket [active]
425104007920	4-fold oligomerization interface [polypeptide binding]; other site
425104007921	metal binding residues [ion binding]; metal-binding site
425104007922	3-fold/trimer interface [polypeptide binding]; other site
425104007923	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
425104007924	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
425104007925	putative active site [active]
425104007926	oxyanion strand; other site
425104007927	catalytic triad [active]
425104007928	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
425104007929	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
425104007930	catalytic residues [active]
425104007931	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
425104007932	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
425104007933	substrate binding site [chemical binding]; other site
425104007934	glutamase interaction surface [polypeptide binding]; other site
425104007935	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
425104007936	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
425104007937	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
425104007938	metal binding site [ion binding]; metal-binding site
425104007939	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
425104007940	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104007941	membrane-bound complex binding site; other site
425104007942	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
425104007943	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
425104007944	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104007945	substrate binding pocket [chemical binding]; other site
425104007946	membrane-bound complex binding site; other site
425104007947	hinge residues; other site
425104007948	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
425104007949	ATP binding site [chemical binding]; other site
425104007950	active site
425104007951	substrate binding site [chemical binding]; other site
425104007952	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
425104007953	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
425104007954	5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231
425104007955	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
425104007956	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
425104007957	trimer interface [polypeptide binding]; other site
425104007958	eyelet of channel; other site
425104007959	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
425104007960	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
425104007961	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
425104007962	putative active site [active]
425104007963	putative NTP binding site [chemical binding]; other site
425104007964	putative nucleic acid binding site [nucleotide binding]; other site
425104007965	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
425104007966	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104007967	Ligand Binding Site [chemical binding]; other site
425104007968	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104007969	Ligand Binding Site [chemical binding]; other site
425104007970	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
425104007971	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
425104007972	Sulfate transporter family; Region: Sulfate_transp; pfam00916
425104007973	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
425104007974	Pirin-related protein [General function prediction only]; Region: COG1741
425104007975	Pirin; Region: Pirin; pfam02678
425104007976	DoxX; Region: DoxX; pfam07681
425104007977	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104007978	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
425104007979	The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431
425104007980	putative dimerization interface [polypeptide binding]; other site
425104007981	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
425104007982	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
425104007983	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
425104007984	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
425104007985	4Fe-4S binding domain; Region: Fer4; pfam00037
425104007986	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
425104007987	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
425104007988	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
425104007989	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104007990	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104007991	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
425104007992	30S subunit binding site; other site
425104007993	Protein required for attachment to host cells; Region: Host_attach; pfam10116
425104007994	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
425104007995	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
425104007996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104007997	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
425104007998	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
425104007999	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104008000	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104008001	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
425104008002	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
425104008003	putative NAD(P) binding site [chemical binding]; other site
425104008004	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
425104008005	putative active site pocket [active]
425104008006	putative catalytic residue [active]
425104008007	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
425104008008	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
425104008009	classical (c) SDRs; Region: SDR_c; cd05233
425104008010	NAD(P) binding site [chemical binding]; other site
425104008011	active site
425104008012	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
425104008013	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104008014	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104008015	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
425104008016	putative effector binding pocket; other site
425104008017	putative dimerization interface [polypeptide binding]; other site
425104008018	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
425104008019	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
425104008020	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
425104008021	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
425104008022	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
425104008023	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104008024	dimerization interface [polypeptide binding]; other site
425104008025	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104008026	dimer interface [polypeptide binding]; other site
425104008027	phosphorylation site [posttranslational modification]
425104008028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104008029	ATP binding site [chemical binding]; other site
425104008030	G-X-G motif; other site
425104008031	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
425104008032	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104008033	active site
425104008034	phosphorylation site [posttranslational modification]
425104008035	intermolecular recognition site; other site
425104008036	dimerization interface [polypeptide binding]; other site
425104008037	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104008038	DNA binding site [nucleotide binding]
425104008039	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104008040	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104008041	LysR substrate binding domain; Region: LysR_substrate; pfam03466
425104008042	dimerization interface [polypeptide binding]; other site
425104008043	putative monooxygenase; Provisional; Region: PRK11118
425104008044	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
425104008045	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
425104008046	putative acyl-acceptor binding pocket; other site
425104008047	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
425104008048	IHF dimer interface [polypeptide binding]; other site
425104008049	IHF - DNA interface [nucleotide binding]; other site
425104008050	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
425104008051	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
425104008052	putative tRNA-binding site [nucleotide binding]; other site
425104008053	B3/4 domain; Region: B3_4; pfam03483
425104008054	tRNA synthetase B5 domain; Region: B5; smart00874
425104008055	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
425104008056	dimer interface [polypeptide binding]; other site
425104008057	motif 1; other site
425104008058	motif 3; other site
425104008059	motif 2; other site
425104008060	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
425104008061	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
425104008062	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
425104008063	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
425104008064	dimer interface [polypeptide binding]; other site
425104008065	motif 1; other site
425104008066	active site
425104008067	motif 2; other site
425104008068	motif 3; other site
425104008069	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104008070	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104008071	dimer interface [polypeptide binding]; other site
425104008072	putative CheW interface [polypeptide binding]; other site
425104008073	PAS fold; Region: PAS_4; pfam08448
425104008074	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104008075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104008076	ATP binding site [chemical binding]; other site
425104008077	Mg2+ binding site [ion binding]; other site
425104008078	G-X-G motif; other site
425104008079	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
425104008080	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
425104008081	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
425104008082	Protein of unknown function (DUF3802); Region: DUF3802; pfam12290
425104008083	YceI-like domain; Region: YceI; pfam04264
425104008084	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
425104008085	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
425104008086	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
425104008087	agmatinase; Region: agmatinase; TIGR01230
425104008088	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
425104008089	oligomer interface [polypeptide binding]; other site
425104008090	putative active site [active]
425104008091	Mn binding site [ion binding]; other site
425104008092	Adenosylmethionine decarboxylase; Region: SAM_decarbox; cl03253
425104008093	arginine decarboxylase; Provisional; Region: PRK05354
425104008094	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
425104008095	dimer interface [polypeptide binding]; other site
425104008096	active site
425104008097	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
425104008098	catalytic residues [active]
425104008099	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
425104008100	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
425104008101	S1 domain; Region: S1_2; pfam13509
425104008102	S1 domain; Region: S1_2; pfam13509
425104008103	hypothetical protein; Provisional; Region: PRK11239
425104008104	Protein of unknown function, DUF480; Region: DUF480; pfam04337
425104008105	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
425104008106	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104008107	Walker A/P-loop; other site
425104008108	ATP binding site [chemical binding]; other site
425104008109	Q-loop/lid; other site
425104008110	ABC transporter signature motif; other site
425104008111	Walker B; other site
425104008112	D-loop; other site
425104008113	H-loop/switch region; other site
425104008114	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
425104008115	DNA-binding site [nucleotide binding]; DNA binding site
425104008116	RNA-binding motif; other site
425104008117	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
425104008118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104008119	S-adenosylmethionine binding site [chemical binding]; other site
425104008120	exonuclease I; Provisional; Region: sbcB; PRK11779
425104008121	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
425104008122	active site
425104008123	catalytic site [active]
425104008124	substrate binding site [chemical binding]; other site
425104008125	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
425104008126	cytidine deaminase; Provisional; Region: PRK09027
425104008127	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
425104008128	active site
425104008129	catalytic motif [active]
425104008130	Zn binding site [ion binding]; other site
425104008131	Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211
425104008132	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
425104008133	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
425104008134	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
425104008135	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
425104008136	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
425104008137	dimer interface [polypeptide binding]; other site
425104008138	active site
425104008139	acyl carrier protein; Provisional; Region: acpP; PRK00982
425104008140	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
425104008141	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
425104008142	NAD(P) binding site [chemical binding]; other site
425104008143	homotetramer interface [polypeptide binding]; other site
425104008144	homodimer interface [polypeptide binding]; other site
425104008145	active site
425104008146	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
425104008147	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
425104008148	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
425104008149	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
425104008150	dimer interface [polypeptide binding]; other site
425104008151	active site
425104008152	CoA binding pocket [chemical binding]; other site
425104008153	putative phosphate acyltransferase; Provisional; Region: PRK05331
425104008154	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
425104008155	hypothetical protein; Provisional; Region: PRK11193
425104008156	Maf-like protein; Region: Maf; pfam02545
425104008157	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
425104008158	active site
425104008159	dimer interface [polypeptide binding]; other site
425104008160	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104008161	PAS domain; Region: PAS_9; pfam13426
425104008162	putative active site [active]
425104008163	heme pocket [chemical binding]; other site
425104008164	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104008165	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104008166	metal binding site [ion binding]; metal-binding site
425104008167	active site
425104008168	I-site; other site
425104008169	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
425104008170	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104008171	motif II; other site
425104008172	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
425104008173	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
425104008174	RNA binding surface [nucleotide binding]; other site
425104008175	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
425104008176	active site
425104008177	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
425104008178	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
425104008179	homodimer interface [polypeptide binding]; other site
425104008180	oligonucleotide binding site [chemical binding]; other site
425104008181	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
425104008182	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
425104008183	Sulfate transporter family; Region: Sulfate_transp; pfam00916
425104008184	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
425104008185	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
425104008186	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
425104008187	methionine sulfoxide reductase A; Provisional; Region: PRK14054
425104008188	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
425104008189	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
425104008190	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
425104008191	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
425104008192	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
425104008193	GTP/Mg2+ binding site [chemical binding]; other site
425104008194	G4 box; other site
425104008195	G5 box; other site
425104008196	G1 box; other site
425104008197	Switch I region; other site
425104008198	G2 box; other site
425104008199	G3 box; other site
425104008200	Switch II region; other site
425104008201	DNA ligase; Provisional; Region: PRK09125
425104008202	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
425104008203	DNA binding site [nucleotide binding]
425104008204	active site
425104008205	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
425104008206	DNA binding site [nucleotide binding]
425104008207	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
425104008208	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
425104008209	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
425104008210	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
425104008211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104008212	S-adenosylmethionine binding site [chemical binding]; other site
425104008213	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
425104008214	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
425104008215	active site
425104008216	PilZ domain; Region: PilZ; cl01260
425104008217	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
425104008218	DNA polymerase III subunit delta'; Validated; Region: PRK08485
425104008219	thymidylate kinase; Validated; Region: tmk; PRK00698
425104008220	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
425104008221	TMP-binding site; other site
425104008222	ATP-binding site [chemical binding]; other site
425104008223	YceG-like family; Region: YceG; pfam02618
425104008224	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
425104008225	dimerization interface [polypeptide binding]; other site
425104008226	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
425104008227	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
425104008228	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104008229	catalytic residue [active]
425104008230	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
425104008231	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
425104008232	ATP-binding site [chemical binding]; other site
425104008233	Sugar specificity; other site
425104008234	Pyrimidine base specificity; other site
425104008235	antiporter inner membrane protein; Provisional; Region: PRK11670
425104008236	Domain of unknown function DUF59; Region: DUF59; cl00941
425104008237	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
425104008238	Walker A motif; other site
425104008239	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
425104008240	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
425104008241	active site
425104008242	HIGH motif; other site
425104008243	KMSKS motif; other site
425104008244	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
425104008245	tRNA binding surface [nucleotide binding]; other site
425104008246	anticodon binding site; other site
425104008247	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
425104008248	dimer interface [polypeptide binding]; other site
425104008249	putative tRNA-binding site [nucleotide binding]; other site
425104008250	YadA-like C-terminal region; Region: YadA; pfam03895
425104008251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
425104008252	CreA protein; Region: CreA; pfam05981
425104008253	putative chaperone; Provisional; Region: PRK11678
425104008254	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
425104008255	nucleotide binding site [chemical binding]; other site
425104008256	putative NEF/HSP70 interaction site [polypeptide binding]; other site
425104008257	SBD interface [polypeptide binding]; other site
425104008258	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
425104008259	putative deacylase active site [active]
425104008260	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
425104008261	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
425104008262	dimer interface [polypeptide binding]; other site
425104008263	active site residues [active]
425104008264	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
425104008265	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
425104008266	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
425104008267	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
425104008268	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
425104008269	active site residue [active]
425104008270	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
425104008271	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
425104008272	putative GSH binding site (G-site) [chemical binding]; other site
425104008273	active site cysteine [active]
425104008274	putative C-terminal domain interface [polypeptide binding]; other site
425104008275	putative dimer interface [polypeptide binding]; other site
425104008276	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
425104008277	putative N-terminal domain interface [polypeptide binding]; other site
425104008278	putative dimer interface [polypeptide binding]; other site
425104008279	putative substrate binding pocket (H-site) [chemical binding]; other site
425104008280	Protein of unknown function (DUF523); Region: DUF523; pfam04463
425104008281	Uncharacterized conserved protein [Function unknown]; Region: COG3272
425104008282	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
425104008283	Methyltransferase domain; Region: Methyltransf_23; pfam13489
425104008284	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104008285	S-adenosylmethionine binding site [chemical binding]; other site
425104008286	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
425104008287	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104008288	putative substrate translocation pore; other site
425104008289	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08979
425104008290	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
425104008291	PYR/PP interface [polypeptide binding]; other site
425104008292	dimer interface [polypeptide binding]; other site
425104008293	TPP binding site [chemical binding]; other site
425104008294	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
425104008295	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
425104008296	TPP-binding site [chemical binding]; other site
425104008297	dimer interface [polypeptide binding]; other site
425104008298	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
425104008299	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
425104008300	putative valine binding site [chemical binding]; other site
425104008301	dimer interface [polypeptide binding]; other site
425104008302	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
425104008303	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
425104008304	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
425104008305	putative dimer interface [polypeptide binding]; other site
425104008306	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
425104008307	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
425104008308	active site
425104008309	metal binding site [ion binding]; metal-binding site
425104008310	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
425104008311	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
425104008312	putative hydrolase; Provisional; Region: PRK11460
425104008313	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
425104008314	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
425104008315	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
425104008316	putative dimer interface [polypeptide binding]; other site
425104008317	N-terminal domain interface [polypeptide binding]; other site
425104008318	putative substrate binding pocket (H-site) [chemical binding]; other site
425104008319	Protein of unknown function (DUF3389); Region: DUF3389; pfam11869
425104008320	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
425104008321	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
425104008322	Predicted transcriptional regulator [Transcription]; Region: COG2378
425104008323	WYL domain; Region: WYL; pfam13280
425104008324	Transglycosylase SLT domain; Region: SLT_2; pfam13406
425104008325	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
425104008326	N-acetyl-D-glucosamine binding site [chemical binding]; other site
425104008327	catalytic residue [active]
425104008328	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
425104008329	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
425104008330	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
425104008331	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
425104008332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104008333	active site
425104008334	phosphorylation site [posttranslational modification]
425104008335	intermolecular recognition site; other site
425104008336	dimerization interface [polypeptide binding]; other site
425104008337	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
425104008338	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
425104008339	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
425104008340	catalytic residue [active]
425104008341	hypothetical protein; Provisional; Region: PRK11770
425104008342	Domain of unknown function (DUF307); Region: DUF307; pfam03733
425104008343	Domain of unknown function (DUF307); Region: DUF307; pfam03733
425104008344	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
425104008345	Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656
425104008346	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
425104008347	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104008348	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104008349	LysR substrate binding domain; Region: LysR_substrate; pfam03466
425104008350	dimerization interface [polypeptide binding]; other site
425104008351	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
425104008352	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
425104008353	dimer interface [polypeptide binding]; other site
425104008354	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
425104008355	active site
425104008356	Fe binding site [ion binding]; other site
425104008357	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
425104008358	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
425104008359	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
425104008360	PAS domain; Region: PAS_9; pfam13426
425104008361	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104008362	putative active site [active]
425104008363	heme pocket [chemical binding]; other site
425104008364	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104008365	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104008366	dimer interface [polypeptide binding]; other site
425104008367	putative CheW interface [polypeptide binding]; other site
425104008368	hypothetical protein; Provisional; Region: PRK06156
425104008369	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
425104008370	active site
425104008371	metal binding site [ion binding]; metal-binding site
425104008372	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
425104008373	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
425104008374	active site
425104008375	Zn binding site [ion binding]; other site
425104008376	Protein of unknown function (DUF938); Region: DUF938; pfam06080
425104008377	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
425104008378	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
425104008379	active site
425104008380	metal binding site [ion binding]; metal-binding site
425104008381	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
425104008382	YibE/F-like protein; Region: YibE_F; pfam07907
425104008383	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
425104008384	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
425104008385	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
425104008386	active site
425104008387	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
425104008388	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
425104008389	active site
425104008390	phosphate binding residues; other site
425104008391	catalytic residues [active]
425104008392	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
425104008393	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
425104008394	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
425104008395	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
425104008396	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
425104008397	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104008398	Coenzyme A binding pocket [chemical binding]; other site
425104008399	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
425104008400	Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: GCD2; COG1184
425104008401	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
425104008402	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104008403	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104008404	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
425104008405	putative effector binding pocket; other site
425104008406	dimerization interface [polypeptide binding]; other site
425104008407	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
425104008408	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
425104008409	active site
425104008410	FMN binding site [chemical binding]; other site
425104008411	substrate binding site [chemical binding]; other site
425104008412	putative catalytic residue [active]
425104008413	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
425104008414	heme-binding residues [chemical binding]; other site
425104008415	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104008416	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
425104008417	dimer interface [polypeptide binding]; other site
425104008418	active site
425104008419	metal binding site [ion binding]; metal-binding site
425104008420	glutathione binding site [chemical binding]; other site
425104008421	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
425104008422	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
425104008423	FMN binding site [chemical binding]; other site
425104008424	active site
425104008425	substrate binding site [chemical binding]; other site
425104008426	catalytic residue [active]
425104008427	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
425104008428	EamA-like transporter family; Region: EamA; pfam00892
425104008429	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
425104008430	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
425104008431	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
425104008432	putative active site [active]
425104008433	putative NTP binding site [chemical binding]; other site
425104008434	putative nucleic acid binding site [nucleotide binding]; other site
425104008435	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
425104008436	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104008437	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
425104008438	active site
425104008439	metal binding site [ion binding]; metal-binding site
425104008440	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
425104008441	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
425104008442	active site
425104008443	purine riboside binding site [chemical binding]; other site
425104008444	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678
425104008445	nudix motif; other site
425104008446	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104008447	Coenzyme A binding pocket [chemical binding]; other site
425104008448	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
425104008449	HAMP domain; Region: HAMP; pfam00672
425104008450	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104008451	dimer interface [polypeptide binding]; other site
425104008452	phosphorylation site [posttranslational modification]
425104008453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104008454	ATP binding site [chemical binding]; other site
425104008455	Mg2+ binding site [ion binding]; other site
425104008456	G-X-G motif; other site
425104008457	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
425104008458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104008459	active site
425104008460	phosphorylation site [posttranslational modification]
425104008461	intermolecular recognition site; other site
425104008462	dimerization interface [polypeptide binding]; other site
425104008463	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104008464	DNA binding site [nucleotide binding]
425104008465	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
425104008466	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
425104008467	potential catalytic triad [active]
425104008468	conserved cys residue [active]
425104008469	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
425104008470	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
425104008471	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
425104008472	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
425104008473	Walker A/P-loop; other site
425104008474	ATP binding site [chemical binding]; other site
425104008475	Q-loop/lid; other site
425104008476	ABC transporter signature motif; other site
425104008477	Walker B; other site
425104008478	D-loop; other site
425104008479	H-loop/switch region; other site
425104008480	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
425104008481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104008482	Walker A/P-loop; other site
425104008483	ATP binding site [chemical binding]; other site
425104008484	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
425104008485	putative active site [active]
425104008486	putative metal-binding site [ion binding]; other site
425104008487	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
425104008488	aspartate racemase; Region: asp_race; TIGR00035
425104008489	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
425104008490	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
425104008491	active site
425104008492	metal binding site [ion binding]; metal-binding site
425104008493	homotetramer interface [polypeptide binding]; other site
425104008494	Activator of aromatic catabolism; Region: XylR_N; pfam06505
425104008495	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
425104008496	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104008497	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
425104008498	Walker A motif; other site
425104008499	ATP binding site [chemical binding]; other site
425104008500	Walker B motif; other site
425104008501	arginine finger; other site
425104008502	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104008503	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
425104008504	Predicted oxidoreductase [General function prediction only]; Region: COG3573
425104008505	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
425104008506	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189
425104008507	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
425104008508	putative active site [active]
425104008509	metal binding site [ion binding]; metal-binding site
425104008510	Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275
425104008511	active site
425104008512	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
425104008513	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
425104008514	FtsX-like permease family; Region: FtsX; pfam02687
425104008515	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104008516	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104008517	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104008518	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104008519	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
425104008520	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104008521	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
425104008522	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
425104008523	Walker A/P-loop; other site
425104008524	ATP binding site [chemical binding]; other site
425104008525	Q-loop/lid; other site
425104008526	ABC transporter signature motif; other site
425104008527	Walker B; other site
425104008528	D-loop; other site
425104008529	H-loop/switch region; other site
425104008530	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
425104008531	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
425104008532	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
425104008533	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
425104008534	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
425104008535	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
425104008536	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
425104008537	putative FMN binding site [chemical binding]; other site
425104008538	DoxX; Region: DoxX; pfam07681
425104008539	Phosphotransferase enzyme family; Region: APH; pfam01636
425104008540	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
425104008541	active site
425104008542	ATP binding site [chemical binding]; other site
425104008543	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
425104008544	substrate binding site [chemical binding]; other site
425104008545	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
425104008546	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
425104008547	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104008548	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
425104008549	putative dimer interface [polypeptide binding]; other site
425104008550	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
425104008551	CoenzymeA binding site [chemical binding]; other site
425104008552	subunit interaction site [polypeptide binding]; other site
425104008553	PHB binding site; other site
425104008554	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
425104008555	CoenzymeA binding site [chemical binding]; other site
425104008556	subunit interaction site [polypeptide binding]; other site
425104008557	PHB binding site; other site
425104008558	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
425104008559	nucleotide binding site/active site [active]
425104008560	HIT family signature motif; other site
425104008561	catalytic residue [active]
425104008562	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104008563	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104008564	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
425104008565	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104008566	DNA binding residues [nucleotide binding]
425104008567	dimerization interface [polypeptide binding]; other site
425104008568	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
425104008569	Tetratricopeptide repeat; Region: TPR_12; pfam13424
425104008570	TPR repeat; Region: TPR_11; pfam13414
425104008571	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104008572	binding surface
425104008573	TPR motif; other site
425104008574	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
425104008575	putative hydrophobic ligand binding site [chemical binding]; other site
425104008576	protein interface [polypeptide binding]; other site
425104008577	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
425104008578	active site
425104008579	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
425104008580	Catalytic domain of Protein Kinases; Region: PKc; cd00180
425104008581	active site
425104008582	ATP binding site [chemical binding]; other site
425104008583	substrate binding site [chemical binding]; other site
425104008584	activation loop (A-loop); other site
425104008585	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
425104008586	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104008587	putative substrate translocation pore; other site
425104008588	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104008589	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
425104008590	nitrite reductase subunit NirD; Provisional; Region: PRK14989
425104008591	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
425104008592	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
425104008593	ANTAR domain; Region: ANTAR; pfam03861
425104008594	hypothetical protein; Validated; Region: PRK09071
425104008595	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
425104008596	active site
425104008597	SAM binding site [chemical binding]; other site
425104008598	homodimer interface [polypeptide binding]; other site
425104008599	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
425104008600	heat shock protein HtpX; Provisional; Region: PRK05457
425104008601	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
425104008602	active site pocket [active]
425104008603	oxyanion hole [active]
425104008604	catalytic triad [active]
425104008605	active site nucleophile [active]
425104008606	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
425104008607	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
425104008608	active site
425104008609	metal binding site [ion binding]; metal-binding site
425104008610	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
425104008611	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
425104008612	AAA domain; Region: AAA_26; pfam13500
425104008613	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
425104008614	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104008615	S-adenosylmethionine binding site [chemical binding]; other site
425104008616	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
425104008617	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
425104008618	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
425104008619	catalytic residue [active]
425104008620	biotin synthase; Provisional; Region: PRK15108
425104008621	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104008622	FeS/SAM binding site; other site
425104008623	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
425104008624	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
425104008625	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
425104008626	inhibitor-cofactor binding pocket; inhibition site
425104008627	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104008628	catalytic residue [active]
425104008629	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
425104008630	fructuronate transporter; Provisional; Region: PRK10034; cl15264
425104008631	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
425104008632	putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799
425104008633	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
425104008634	catalytic residue [active]
425104008635	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
425104008636	EF-hand domain pair; Region: EF_hand_5; pfam13499
425104008637	Ca2+ binding site [ion binding]; other site
425104008638	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
425104008639	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
425104008640	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104008641	dimerization interface [polypeptide binding]; other site
425104008642	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104008643	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104008644	dimer interface [polypeptide binding]; other site
425104008645	putative CheW interface [polypeptide binding]; other site
425104008646	Uncharacterized conserved protein [Function unknown]; Region: COG3391
425104008647	Predicted transcriptional regulator [Transcription]; Region: COG2378
425104008648	HTH domain; Region: HTH_11; pfam08279
425104008649	WYL domain; Region: WYL; pfam13280
425104008650	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
425104008651	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
425104008652	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104008653	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
425104008654	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
425104008655	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
425104008656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104008657	S-adenosylmethionine binding site [chemical binding]; other site
425104008658	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
425104008659	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
425104008660	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
425104008661	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
425104008662	trimer interface [polypeptide binding]; other site
425104008663	active site
425104008664	substrate binding site [chemical binding]; other site
425104008665	CoA binding site [chemical binding]; other site
425104008666	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
425104008667	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
425104008668	DNA binding residues [nucleotide binding]
425104008669	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104008670	Coenzyme A binding pocket [chemical binding]; other site
425104008671	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
425104008672	4Fe-4S binding domain; Region: Fer4; pfam00037
425104008673	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
425104008674	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
425104008675	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
425104008676	[4Fe-4S] binding site [ion binding]; other site
425104008677	molybdopterin cofactor binding site; other site
425104008678	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
425104008679	molybdopterin cofactor binding site; other site
425104008680	ecotin; Provisional; Region: PRK03719
425104008681	secondary substrate binding site; other site
425104008682	primary substrate binding site; other site
425104008683	inhibition loop; other site
425104008684	dimerization interface [polypeptide binding]; other site
425104008685	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
425104008686	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
425104008687	Na binding site [ion binding]; other site
425104008688	putative substrate binding site [chemical binding]; other site
425104008689	cytosine deaminase; Provisional; Region: PRK09230
425104008690	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
425104008691	active site
425104008692	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271
425104008693	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
425104008694	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
425104008695	putative acetyltransferase YhhY; Provisional; Region: PRK10140
425104008696	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104008697	Coenzyme A binding pocket [chemical binding]; other site
425104008698	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
425104008699	AAA domain; Region: AAA_33; pfam13671
425104008700	NAD-dependent deacetylase; Provisional; Region: PRK00481
425104008701	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
425104008702	NAD+ binding site [chemical binding]; other site
425104008703	substrate binding site [chemical binding]; other site
425104008704	Zn binding site [ion binding]; other site
425104008705	ferric uptake regulator; Provisional; Region: fur; PRK09462
425104008706	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
425104008707	metal binding site 2 [ion binding]; metal-binding site
425104008708	putative DNA binding helix; other site
425104008709	metal binding site 1 [ion binding]; metal-binding site
425104008710	dimer interface [polypeptide binding]; other site
425104008711	structural Zn2+ binding site [ion binding]; other site
425104008712	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
425104008713	CoA binding domain; Region: CoA_binding; pfam02629
425104008714	CoA-ligase; Region: Ligase_CoA; pfam00549
425104008715	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
425104008716	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
425104008717	CoA-ligase; Region: Ligase_CoA; pfam00549
425104008718	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
425104008719	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
425104008720	E3 interaction surface; other site
425104008721	lipoyl attachment site [posttranslational modification]; other site
425104008722	e3 binding domain; Region: E3_binding; pfam02817
425104008723	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
425104008724	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
425104008725	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
425104008726	TPP-binding site [chemical binding]; other site
425104008727	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
425104008728	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
425104008729	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
425104008730	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
425104008731	L-aspartate oxidase; Provisional; Region: PRK06175
425104008732	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
425104008733	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
425104008734	SdhC subunit interface [polypeptide binding]; other site
425104008735	proximal heme binding site [chemical binding]; other site
425104008736	cardiolipin binding site; other site
425104008737	Iron-sulfur protein interface; other site
425104008738	proximal quinone binding site [chemical binding]; other site
425104008739	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
425104008740	Iron-sulfur protein interface; other site
425104008741	proximal quinone binding site [chemical binding]; other site
425104008742	SdhD (CybS) interface [polypeptide binding]; other site
425104008743	proximal heme binding site [chemical binding]; other site
425104008744	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
425104008745	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
425104008746	dimer interface [polypeptide binding]; other site
425104008747	active site
425104008748	citrylCoA binding site [chemical binding]; other site
425104008749	NADH binding [chemical binding]; other site
425104008750	cationic pore residues; other site
425104008751	oxalacetate/citrate binding site [chemical binding]; other site
425104008752	coenzyme A binding site [chemical binding]; other site
425104008753	catalytic triad [active]
425104008754	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104008755	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104008756	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104008757	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
425104008758	Protein export membrane protein; Region: SecD_SecF; cl14618
425104008759	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104008760	Protein export membrane protein; Region: SecD_SecF; cl14618
425104008761	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
425104008762	Uncharacterized conserved protein [Function unknown]; Region: COG2835
425104008763	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
425104008764	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
425104008765	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
425104008766	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
425104008767	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
425104008768	Walker A/P-loop; other site
425104008769	ATP binding site [chemical binding]; other site
425104008770	Q-loop/lid; other site
425104008771	ABC transporter signature motif; other site
425104008772	Walker B; other site
425104008773	D-loop; other site
425104008774	H-loop/switch region; other site
425104008775	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
425104008776	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
425104008777	Competence protein; Region: Competence; pfam03772
425104008778	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
425104008779	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
425104008780	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
425104008781	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
425104008782	FtsX-like permease family; Region: FtsX; pfam02687
425104008783	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
425104008784	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
425104008785	Walker A/P-loop; other site
425104008786	ATP binding site [chemical binding]; other site
425104008787	Q-loop/lid; other site
425104008788	ABC transporter signature motif; other site
425104008789	Walker B; other site
425104008790	D-loop; other site
425104008791	H-loop/switch region; other site
425104008792	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
425104008793	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
425104008794	FtsX-like permease family; Region: FtsX; pfam02687
425104008795	transcription-repair coupling factor; Provisional; Region: PRK10689
425104008796	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
425104008797	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104008798	ATP binding site [chemical binding]; other site
425104008799	putative Mg++ binding site [ion binding]; other site
425104008800	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104008801	nucleotide binding region [chemical binding]; other site
425104008802	ATP-binding site [chemical binding]; other site
425104008803	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
425104008804	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
425104008805	acylphosphatase; Provisional; Region: PRK14429
425104008806	hypothetical protein; Provisional; Region: PRK04940
425104008807	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
425104008808	beta-hexosaminidase; Provisional; Region: PRK05337
425104008809	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
425104008810	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
425104008811	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
425104008812	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
425104008813	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104008814	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
425104008815	substrate binding site [chemical binding]; other site
425104008816	dimerization interface [polypeptide binding]; other site
425104008817	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
425104008818	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
425104008819	active site
425104008820	interdomain interaction site; other site
425104008821	putative metal-binding site [ion binding]; other site
425104008822	nucleotide binding site [chemical binding]; other site
425104008823	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
425104008824	domain I; other site
425104008825	DNA binding groove [nucleotide binding]
425104008826	phosphate binding site [ion binding]; other site
425104008827	domain II; other site
425104008828	domain III; other site
425104008829	nucleotide binding site [chemical binding]; other site
425104008830	catalytic site [active]
425104008831	domain IV; other site
425104008832	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
425104008833	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
425104008834	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
425104008835	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
425104008836	succinylarginine dihydrolase; Provisional; Region: PRK13281
425104008837	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
425104008838	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
425104008839	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
425104008840	inosine/guanosine kinase; Provisional; Region: PRK15074
425104008841	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
425104008842	ferrochelatase; Reviewed; Region: hemH; PRK00035
425104008843	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
425104008844	C-terminal domain interface [polypeptide binding]; other site
425104008845	active site
425104008846	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
425104008847	active site
425104008848	N-terminal domain interface [polypeptide binding]; other site
425104008849	adenylate kinase; Reviewed; Region: adk; PRK00279
425104008850	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
425104008851	AMP-binding site [chemical binding]; other site
425104008852	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
425104008853	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
425104008854	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
425104008855	heat shock protein 90; Provisional; Region: PRK05218
425104008856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104008857	ATP binding site [chemical binding]; other site
425104008858	Mg2+ binding site [ion binding]; other site
425104008859	G-X-G motif; other site
425104008860	recombination protein RecR; Reviewed; Region: recR; PRK00076
425104008861	RecR protein; Region: RecR; pfam02132
425104008862	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
425104008863	putative active site [active]
425104008864	putative metal-binding site [ion binding]; other site
425104008865	tetramer interface [polypeptide binding]; other site
425104008866	hypothetical protein; Validated; Region: PRK00153
425104008867	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949
425104008868	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104008869	Walker A motif; other site
425104008870	ATP binding site [chemical binding]; other site
425104008871	Walker B motif; other site
425104008872	arginine finger; other site
425104008873	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
425104008874	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
425104008875	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
425104008876	active site
425104008877	hypothetical protein; Provisional; Region: PRK10527
425104008878	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
425104008879	hypothetical protein; Provisional; Region: PRK05409
425104008880	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
425104008881	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
425104008882	FMN binding site [chemical binding]; other site
425104008883	active site
425104008884	catalytic residues [active]
425104008885	substrate binding site [chemical binding]; other site
425104008886	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
425104008887	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
425104008888	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104008889	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
425104008890	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104008891	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
425104008892	active site
425104008893	multimer interface [polypeptide binding]; other site
425104008894	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
425104008895	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
425104008896	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104008897	active site
425104008898	phosphorylation site [posttranslational modification]
425104008899	intermolecular recognition site; other site
425104008900	dimerization interface [polypeptide binding]; other site
425104008901	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104008902	Zn2+ binding site [ion binding]; other site
425104008903	Mg2+ binding site [ion binding]; other site
425104008904	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104008905	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104008906	substrate binding pocket [chemical binding]; other site
425104008907	membrane-bound complex binding site; other site
425104008908	hinge residues; other site
425104008909	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104008910	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104008911	substrate binding pocket [chemical binding]; other site
425104008912	membrane-bound complex binding site; other site
425104008913	hinge residues; other site
425104008914	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104008915	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104008916	substrate binding pocket [chemical binding]; other site
425104008917	membrane-bound complex binding site; other site
425104008918	hinge residues; other site
425104008919	PAS domain S-box; Region: sensory_box; TIGR00229
425104008920	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104008921	putative active site [active]
425104008922	heme pocket [chemical binding]; other site
425104008923	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
425104008924	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104008925	putative active site [active]
425104008926	heme pocket [chemical binding]; other site
425104008927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104008928	dimer interface [polypeptide binding]; other site
425104008929	phosphorylation site [posttranslational modification]
425104008930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104008931	ATP binding site [chemical binding]; other site
425104008932	Mg2+ binding site [ion binding]; other site
425104008933	G-X-G motif; other site
425104008934	Response regulator receiver domain; Region: Response_reg; pfam00072
425104008935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104008936	active site
425104008937	phosphorylation site [posttranslational modification]
425104008938	intermolecular recognition site; other site
425104008939	dimerization interface [polypeptide binding]; other site
425104008940	Response regulator receiver domain; Region: Response_reg; pfam00072
425104008941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104008942	active site
425104008943	phosphorylation site [posttranslational modification]
425104008944	intermolecular recognition site; other site
425104008945	dimerization interface [polypeptide binding]; other site
425104008946	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
425104008947	putative binding surface; other site
425104008948	active site
425104008949	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
425104008950	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
425104008951	catalytic loop [active]
425104008952	iron binding site [ion binding]; other site
425104008953	chaperone protein HscA; Provisional; Region: hscA; PRK05183
425104008954	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
425104008955	nucleotide binding site [chemical binding]; other site
425104008956	putative NEF/HSP70 interaction site [polypeptide binding]; other site
425104008957	SBD interface [polypeptide binding]; other site
425104008958	co-chaperone HscB; Provisional; Region: hscB; PRK05014
425104008959	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
425104008960	HSP70 interaction site [polypeptide binding]; other site
425104008961	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
425104008962	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
425104008963	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
425104008964	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
425104008965	trimerization site [polypeptide binding]; other site
425104008966	active site
425104008967	cysteine desulfurase; Provisional; Region: PRK14012
425104008968	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
425104008969	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
425104008970	catalytic residue [active]
425104008971	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
425104008972	Rrf2 family protein; Region: rrf2_super; TIGR00738
425104008973	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
425104008974	serine O-acetyltransferase; Region: cysE; TIGR01172
425104008975	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
425104008976	trimer interface [polypeptide binding]; other site
425104008977	active site
425104008978	substrate binding site [chemical binding]; other site
425104008979	CoA binding site [chemical binding]; other site
425104008980	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
425104008981	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
425104008982	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
425104008983	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
425104008984	active site
425104008985	dimerization interface [polypeptide binding]; other site
425104008986	NnrS protein; Region: NnrS; pfam05940
425104008987	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
425104008988	PilZ domain; Region: PilZ; pfam07238
425104008989	ParA-like protein; Provisional; Region: PHA02518
425104008990	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
425104008991	P-loop; other site
425104008992	Magnesium ion binding site [ion binding]; other site
425104008993	probable metal-binding protein; Region: matur_matur; TIGR03853
425104008994	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
425104008995	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
425104008996	GAF domain; Region: GAF; pfam01590
425104008997	Histidine kinase; Region: His_kinase; pfam06580
425104008998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104008999	ATP binding site [chemical binding]; other site
425104009000	Mg2+ binding site [ion binding]; other site
425104009001	G-X-G motif; other site
425104009002	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
425104009003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009004	active site
425104009005	phosphorylation site [posttranslational modification]
425104009006	intermolecular recognition site; other site
425104009007	dimerization interface [polypeptide binding]; other site
425104009008	LytTr DNA-binding domain; Region: LytTR; smart00850
425104009009	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
425104009010	Carbon starvation protein CstA; Region: CstA; pfam02554
425104009011	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
425104009012	YaeQ protein; Region: YaeQ; pfam07152
425104009013	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
425104009014	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
425104009015	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
425104009016	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
425104009017	active site residue [active]
425104009018	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
425104009019	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
425104009020	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
425104009021	Protein export membrane protein; Region: SecD_SecF; pfam02355
425104009022	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
425104009023	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
425104009024	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
425104009025	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
425104009026	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
425104009027	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
425104009028	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
425104009029	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
425104009030	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
425104009031	Protein of unknown function, DUF479; Region: DUF479; cl01203
425104009032	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
425104009033	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
425104009034	active site
425104009035	serine/threonine transporter SstT; Provisional; Region: PRK13628
425104009036	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
425104009037	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
425104009038	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
425104009039	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009040	active site
425104009041	phosphorylation site [posttranslational modification]
425104009042	intermolecular recognition site; other site
425104009043	dimerization interface [polypeptide binding]; other site
425104009044	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
425104009045	PLD-like domain; Region: PLDc_2; pfam13091
425104009046	putative active site [active]
425104009047	catalytic site [active]
425104009048	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
425104009049	PLD-like domain; Region: PLDc_2; pfam13091
425104009050	putative active site [active]
425104009051	catalytic site [active]
425104009052	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
425104009053	active site
425104009054	catalytic residues [active]
425104009055	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
425104009056	DEAD-like helicases superfamily; Region: DEXDc; smart00487
425104009057	ATP binding site [chemical binding]; other site
425104009058	Mg++ binding site [ion binding]; other site
425104009059	motif III; other site
425104009060	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104009061	nucleotide binding region [chemical binding]; other site
425104009062	ATP-binding site [chemical binding]; other site
425104009063	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
425104009064	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
425104009065	DNA binding site [nucleotide binding]
425104009066	active site
425104009067	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
425104009068	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
425104009069	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104009070	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104009071	AlkA N-terminal domain; Region: AlkA_N; pfam06029
425104009072	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
425104009073	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
425104009074	minor groove reading motif; other site
425104009075	helix-hairpin-helix signature motif; other site
425104009076	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
425104009077	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
425104009078	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
425104009079	Walker A/P-loop; other site
425104009080	ATP binding site [chemical binding]; other site
425104009081	Q-loop/lid; other site
425104009082	ABC transporter signature motif; other site
425104009083	Walker B; other site
425104009084	D-loop; other site
425104009085	H-loop/switch region; other site
425104009086	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
425104009087	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
425104009088	active site
425104009089	HIGH motif; other site
425104009090	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
425104009091	active site
425104009092	KMSKS motif; other site
425104009093	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
425104009094	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
425104009095	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
425104009096	DctM-like transporters; Region: DctM; pfam06808
425104009097	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
425104009098	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
425104009099	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104009100	dimer interface [polypeptide binding]; other site
425104009101	phosphorylation site [posttranslational modification]
425104009102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104009103	ATP binding site [chemical binding]; other site
425104009104	Mg2+ binding site [ion binding]; other site
425104009105	G-X-G motif; other site
425104009106	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
425104009107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009108	active site
425104009109	phosphorylation site [posttranslational modification]
425104009110	intermolecular recognition site; other site
425104009111	dimerization interface [polypeptide binding]; other site
425104009112	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104009113	Walker A motif; other site
425104009114	ATP binding site [chemical binding]; other site
425104009115	Walker B motif; other site
425104009116	arginine finger; other site
425104009117	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104009118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104009119	Major Facilitator Superfamily; Region: MFS_1; pfam07690
425104009120	putative substrate translocation pore; other site
425104009121	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104009122	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104009123	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104009124	dimerization interface [polypeptide binding]; other site
425104009125	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104009126	Protein export membrane protein; Region: SecD_SecF; cl14618
425104009127	Protein export membrane protein; Region: SecD_SecF; cl14618
425104009128	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104009129	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104009130	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104009131	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104009132	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
425104009133	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104009134	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104009135	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104009136	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
425104009137	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
425104009138	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
425104009139	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
425104009140	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
425104009141	molybdopterin cofactor binding site; other site
425104009142	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
425104009143	putative molybdopterin cofactor binding site; other site
425104009144	Protein of unknown function (DUF3374); Region: DUF3374; pfam11854
425104009145	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104009146	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
425104009147	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104009148	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
425104009149	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
425104009150	maleylacetoacetate isomerase; Region: maiA; TIGR01262
425104009151	C-terminal domain interface [polypeptide binding]; other site
425104009152	GSH binding site (G-site) [chemical binding]; other site
425104009153	putative dimer interface [polypeptide binding]; other site
425104009154	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
425104009155	dimer interface [polypeptide binding]; other site
425104009156	N-terminal domain interface [polypeptide binding]; other site
425104009157	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
425104009158	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
425104009159	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
425104009160	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
425104009161	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
425104009162	putative aromatic amino acid binding site; other site
425104009163	PAS domain; Region: PAS; smart00091
425104009164	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104009165	Walker A motif; other site
425104009166	ATP binding site [chemical binding]; other site
425104009167	Walker B motif; other site
425104009168	arginine finger; other site
425104009169	GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508
425104009170	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
425104009171	aromatic arch; other site
425104009172	DCoH dimer interaction site [polypeptide binding]; other site
425104009173	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
425104009174	DCoH tetramer interaction site [polypeptide binding]; other site
425104009175	substrate binding site [chemical binding]; other site
425104009176	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
425104009177	cofactor binding site; other site
425104009178	metal binding site [ion binding]; metal-binding site
425104009179	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
425104009180	active site
425104009181	tetramer interface; other site
425104009182	UDP-glucose 4-epimerase; Region: PLN02240
425104009183	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
425104009184	NAD binding site [chemical binding]; other site
425104009185	homodimer interface [polypeptide binding]; other site
425104009186	active site
425104009187	substrate binding site [chemical binding]; other site
425104009188	ferredoxin-type protein; Provisional; Region: PRK10194
425104009189	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
425104009190	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
425104009191	Protein of unknown function (DUF2982); Region: DUF2982; pfam11201
425104009192	Uncharacterized conserved protein [Function unknown]; Region: COG1434
425104009193	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
425104009194	putative active site [active]
425104009195	fructokinase; Reviewed; Region: PRK09557
425104009196	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
425104009197	nucleotide binding site [chemical binding]; other site
425104009198	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
425104009199	putative hydrolase; Validated; Region: PRK09248
425104009200	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
425104009201	active site
425104009202	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
425104009203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009204	active site
425104009205	phosphorylation site [posttranslational modification]
425104009206	intermolecular recognition site; other site
425104009207	dimerization interface [polypeptide binding]; other site
425104009208	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104009209	Walker A motif; other site
425104009210	ATP binding site [chemical binding]; other site
425104009211	Walker B motif; other site
425104009212	arginine finger; other site
425104009213	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104009214	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104009215	dimerization interface [polypeptide binding]; other site
425104009216	PAS domain S-box; Region: sensory_box; TIGR00229
425104009217	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104009218	putative active site [active]
425104009219	heme pocket [chemical binding]; other site
425104009220	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
425104009221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104009222	putative active site [active]
425104009223	heme pocket [chemical binding]; other site
425104009224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104009225	dimer interface [polypeptide binding]; other site
425104009226	phosphorylation site [posttranslational modification]
425104009227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104009228	ATP binding site [chemical binding]; other site
425104009229	Mg2+ binding site [ion binding]; other site
425104009230	G-X-G motif; other site
425104009231	Response regulator receiver domain; Region: Response_reg; pfam00072
425104009232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009233	active site
425104009234	phosphorylation site [posttranslational modification]
425104009235	intermolecular recognition site; other site
425104009236	dimerization interface [polypeptide binding]; other site
425104009237	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
425104009238	putative binding surface; other site
425104009239	active site
425104009240	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
425104009241	Response regulator receiver domain; Region: Response_reg; pfam00072
425104009242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009243	active site
425104009244	phosphorylation site [posttranslational modification]
425104009245	intermolecular recognition site; other site
425104009246	dimerization interface [polypeptide binding]; other site
425104009247	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
425104009248	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
425104009249	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
425104009250	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
425104009251	anti sigma factor interaction site; other site
425104009252	regulatory phosphorylation site [posttranslational modification]; other site
425104009253	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
425104009254	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
425104009255	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
425104009256	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
425104009257	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
425104009258	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
425104009259	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
425104009260	active site
425104009261	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
425104009262	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
425104009263	Bacterial sugar transferase; Region: Bac_transf; pfam02397
425104009264	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
425104009265	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
425104009266	active site
425104009267	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
425104009268	putative trimer interface [polypeptide binding]; other site
425104009269	putative CoA binding site [chemical binding]; other site
425104009270	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
425104009271	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
425104009272	active site
425104009273	nucleotide binding site [chemical binding]; other site
425104009274	HIGH motif; other site
425104009275	KMSKS motif; other site
425104009276	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
425104009277	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
425104009278	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
425104009279	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
425104009280	substrate binding site; other site
425104009281	tetramer interface; other site
425104009282	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
425104009283	ligand-binding site [chemical binding]; other site
425104009284	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
425104009285	four helix bundle protein; Region: TIGR02436
425104009286	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
425104009287	TrkA-C domain; Region: TrkA_C; pfam02080
425104009288	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
425104009289	TrkA-C domain; Region: TrkA_C; pfam02080
425104009290	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
425104009291	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
425104009292	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
425104009293	CysD dimerization site [polypeptide binding]; other site
425104009294	G1 box; other site
425104009295	putative GEF interaction site [polypeptide binding]; other site
425104009296	GTP/Mg2+ binding site [chemical binding]; other site
425104009297	Switch I region; other site
425104009298	G2 box; other site
425104009299	G3 box; other site
425104009300	Switch II region; other site
425104009301	G4 box; other site
425104009302	G5 box; other site
425104009303	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
425104009304	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
425104009305	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
425104009306	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
425104009307	Active Sites [active]
425104009308	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
425104009309	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
425104009310	Beta-Casp domain; Region: Beta-Casp; smart01027
425104009311	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
425104009312	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
425104009313	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
425104009314	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
425104009315	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
425104009316	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
425104009317	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
425104009318	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
425104009319	active site
425104009320	homodimer interface [polypeptide binding]; other site
425104009321	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
425104009322	active site
425104009323	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
425104009324	homodimer interface [polypeptide binding]; other site
425104009325	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
425104009326	active site
425104009327	trimer interface [polypeptide binding]; other site
425104009328	substrate binding site [chemical binding]; other site
425104009329	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
425104009330	CoA binding site [chemical binding]; other site
425104009331	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
425104009332	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
425104009333	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
425104009334	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
425104009335	inhibitor-cofactor binding pocket; inhibition site
425104009336	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104009337	catalytic residue [active]
425104009338	putative trimer interface [polypeptide binding]; other site
425104009339	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
425104009340	putative CoA binding site [chemical binding]; other site
425104009341	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
425104009342	putative trimer interface [polypeptide binding]; other site
425104009343	putative active site [active]
425104009344	putative substrate binding site [chemical binding]; other site
425104009345	putative CoA binding site [chemical binding]; other site
425104009346	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
425104009347	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
425104009348	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
425104009349	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
425104009350	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
425104009351	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
425104009352	Chain length determinant protein; Region: Wzz; cl15801
425104009353	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
425104009354	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
425104009355	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
425104009356	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
425104009357	putative glycosyl transferase; Provisional; Region: PRK10018
425104009358	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
425104009359	active site
425104009360	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
425104009361	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
425104009362	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
425104009363	FMN binding site [chemical binding]; other site
425104009364	dimer interface [polypeptide binding]; other site
425104009365	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
425104009366	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
425104009367	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
425104009368	ligand-binding site [chemical binding]; other site
425104009369	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
425104009370	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
425104009371	TrkA-C domain; Region: TrkA_C; pfam02080
425104009372	TrkA-C domain; Region: TrkA_C; pfam02080
425104009373	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
425104009374	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
425104009375	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
425104009376	CysD dimerization site [polypeptide binding]; other site
425104009377	G1 box; other site
425104009378	putative GEF interaction site [polypeptide binding]; other site
425104009379	GTP/Mg2+ binding site [chemical binding]; other site
425104009380	Switch I region; other site
425104009381	G2 box; other site
425104009382	G3 box; other site
425104009383	Switch II region; other site
425104009384	G4 box; other site
425104009385	G5 box; other site
425104009386	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
425104009387	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
425104009388	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
425104009389	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
425104009390	Active Sites [active]
425104009391	Transposase IS200 like; Region: Y1_Tnp; cl00848
425104009392	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
425104009393	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
425104009394	NAD binding site [chemical binding]; other site
425104009395	substrate binding site [chemical binding]; other site
425104009396	homodimer interface [polypeptide binding]; other site
425104009397	active site
425104009398	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
425104009399	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
425104009400	active site
425104009401	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
425104009402	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
425104009403	Probable Catalytic site; other site
425104009404	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
425104009405	WbqC-like protein family; Region: WbqC; pfam08889
425104009406	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
425104009407	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104009408	NAD(P) binding site [chemical binding]; other site
425104009409	active site
425104009410	Protein of unknown function (DUF563); Region: DUF563; pfam04577
425104009411	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104009412	binding surface
425104009413	Tetratricopeptide repeat; Region: TPR_16; pfam13432
425104009414	TPR motif; other site
425104009415	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
425104009416	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
425104009417	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
425104009418	catalytic residue [active]
425104009419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
425104009420	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
425104009421	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
425104009422	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
425104009423	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
425104009424	active site
425104009425	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
425104009426	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
425104009427	NADP binding site [chemical binding]; other site
425104009428	active site
425104009429	putative substrate binding site [chemical binding]; other site
425104009430	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
425104009431	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
425104009432	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
425104009433	substrate binding site; other site
425104009434	tetramer interface; other site
425104009435	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
425104009436	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
425104009437	Walker A/P-loop; other site
425104009438	ATP binding site [chemical binding]; other site
425104009439	Q-loop/lid; other site
425104009440	ABC transporter signature motif; other site
425104009441	Walker B; other site
425104009442	D-loop; other site
425104009443	H-loop/switch region; other site
425104009444	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
425104009445	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
425104009446	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
425104009447	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
425104009448	Ligand binding site; other site
425104009449	Putative Catalytic site; other site
425104009450	DXD motif; other site
425104009451	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
425104009452	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104009453	binding surface
425104009454	TPR motif; other site
425104009455	type II secretion system protein D; Region: type_II_gspD; TIGR02517
425104009456	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
425104009457	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
425104009458	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
425104009459	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
425104009460	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
425104009461	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
425104009462	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
425104009463	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
425104009464	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
425104009465	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
425104009466	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
425104009467	Walker A motif; other site
425104009468	ATP binding site [chemical binding]; other site
425104009469	Walker B motif; other site
425104009470	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
425104009471	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
425104009472	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
425104009473	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
425104009474	Mg++ binding site [ion binding]; other site
425104009475	putative catalytic motif [active]
425104009476	substrate binding site [chemical binding]; other site
425104009477	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
425104009478	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
425104009479	SLBB domain; Region: SLBB; pfam10531
425104009480	SLBB domain; Region: SLBB; pfam10531
425104009481	SLBB domain; Region: SLBB; pfam10531
425104009482	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
425104009483	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
425104009484	transcriptional activator RfaH; Region: RfaH; TIGR01955
425104009485	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
425104009486	heterodimer interface [polypeptide binding]; other site
425104009487	homodimer interface [polypeptide binding]; other site
425104009488	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104009489	putative substrate translocation pore; other site
425104009490	POT family; Region: PTR2; cl17359
425104009491	hypothetical protein; Reviewed; Region: PRK12275
425104009492	four helix bundle protein; Region: TIGR02436
425104009493	Response regulator receiver domain; Region: Response_reg; pfam00072
425104009494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009495	active site
425104009496	phosphorylation site [posttranslational modification]
425104009497	intermolecular recognition site; other site
425104009498	dimerization interface [polypeptide binding]; other site
425104009499	VacJ like lipoprotein; Region: VacJ; cl01073
425104009500	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
425104009501	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
425104009502	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
425104009503	putative CheA interaction surface; other site
425104009504	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
425104009505	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
425104009506	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
425104009507	P-loop; other site
425104009508	Magnesium ion binding site [ion binding]; other site
425104009509	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
425104009510	Magnesium ion binding site [ion binding]; other site
425104009511	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
425104009512	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009513	active site
425104009514	phosphorylation site [posttranslational modification]
425104009515	intermolecular recognition site; other site
425104009516	dimerization interface [polypeptide binding]; other site
425104009517	CheB methylesterase; Region: CheB_methylest; pfam01339
425104009518	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
425104009519	putative binding surface; other site
425104009520	active site
425104009521	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
425104009522	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
425104009523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104009524	ATP binding site [chemical binding]; other site
425104009525	Mg2+ binding site [ion binding]; other site
425104009526	G-X-G motif; other site
425104009527	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
425104009528	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
425104009529	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
425104009530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009531	active site
425104009532	phosphorylation site [posttranslational modification]
425104009533	intermolecular recognition site; other site
425104009534	dimerization interface [polypeptide binding]; other site
425104009535	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
425104009536	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
425104009537	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
425104009538	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
425104009539	DNA binding residues [nucleotide binding]
425104009540	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
425104009541	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
425104009542	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
425104009543	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
425104009544	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
425104009545	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
425104009546	FHIPEP family; Region: FHIPEP; pfam00771
425104009547	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
425104009548	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
425104009549	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
425104009550	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
425104009551	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
425104009552	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
425104009553	flagellar motor switch protein; Validated; Region: fliN; PRK08983
425104009554	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
425104009555	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
425104009556	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
425104009557	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
425104009558	Flagellar FliJ protein; Region: FliJ; pfam02050
425104009559	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
425104009560	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972
425104009561	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
425104009562	Walker A motif/ATP binding site; other site
425104009563	Walker B motif; other site
425104009564	flagellar assembly protein H; Validated; Region: fliH; PRK05687
425104009565	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
425104009566	Flagellar assembly protein FliH; Region: FliH; pfam02108
425104009567	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
425104009568	MgtE intracellular N domain; Region: MgtE_N; smart00924
425104009569	FliG C-terminal domain; Region: FliG_C; pfam01706
425104009570	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
425104009571	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
425104009572	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
425104009573	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
425104009574	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
425104009575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009576	active site
425104009577	phosphorylation site [posttranslational modification]
425104009578	intermolecular recognition site; other site
425104009579	dimerization interface [polypeptide binding]; other site
425104009580	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104009581	Walker A motif; other site
425104009582	ATP binding site [chemical binding]; other site
425104009583	Walker B motif; other site
425104009584	arginine finger; other site
425104009585	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104009586	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104009587	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104009588	putative active site [active]
425104009589	heme pocket [chemical binding]; other site
425104009590	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104009591	dimer interface [polypeptide binding]; other site
425104009592	phosphorylation site [posttranslational modification]
425104009593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104009594	ATP binding site [chemical binding]; other site
425104009595	Mg2+ binding site [ion binding]; other site
425104009596	G-X-G motif; other site
425104009597	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
425104009598	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
425104009599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104009600	Walker A motif; other site
425104009601	ATP binding site [chemical binding]; other site
425104009602	Walker B motif; other site
425104009603	arginine finger; other site
425104009604	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104009605	flagellar protein FliS; Validated; Region: fliS; PRK05685
425104009606	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
425104009607	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
425104009608	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
425104009609	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
425104009610	FlaG protein; Region: FlaG; pfam03646
425104009611	flagellin; Provisional; Region: PRK12802
425104009612	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
425104009613	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
425104009614	flagellin; Provisional; Region: PRK12802
425104009615	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
425104009616	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
425104009617	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
425104009618	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
425104009619	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
425104009620	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
425104009621	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
425104009622	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
425104009623	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
425104009624	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
425104009625	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
425104009626	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
425104009627	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
425104009628	Flagellar L-ring protein; Region: FlgH; pfam02107
425104009629	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
425104009630	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
425104009631	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
425104009632	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
425104009633	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
425104009634	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
425104009635	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
425104009636	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
425104009637	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
425104009638	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
425104009639	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
425104009640	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
425104009641	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631
425104009642	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
425104009643	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
425104009644	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12625
425104009645	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
425104009646	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
425104009647	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
425104009648	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104009649	S-adenosylmethionine binding site [chemical binding]; other site
425104009650	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
425104009651	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
425104009652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009653	active site
425104009654	phosphorylation site [posttranslational modification]
425104009655	intermolecular recognition site; other site
425104009656	dimerization interface [polypeptide binding]; other site
425104009657	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
425104009658	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
425104009659	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
425104009660	FlgN protein; Region: FlgN; pfam05130
425104009661	LPP20 lipoprotein; Region: LPP20; pfam02169
425104009662	GSCFA family; Region: GSCFA; pfam08885
425104009663	BTB And C-terminal Kelch; Region: BACK; cl06652
425104009664	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
425104009665	NAD(P) binding site [chemical binding]; other site
425104009666	homodimer interface [polypeptide binding]; other site
425104009667	substrate binding site [chemical binding]; other site
425104009668	active site
425104009669	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
425104009670	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
425104009671	inhibitor-cofactor binding pocket; inhibition site
425104009672	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104009673	catalytic residue [active]
425104009674	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
425104009675	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
425104009676	active site
425104009677	homodimer interface [polypeptide binding]; other site
425104009678	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
425104009679	NeuB family; Region: NeuB; pfam03102
425104009680	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
425104009681	NeuB binding interface [polypeptide binding]; other site
425104009682	putative substrate binding site [chemical binding]; other site
425104009683	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
425104009684	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
425104009685	putative trimer interface [polypeptide binding]; other site
425104009686	putative CoA binding site [chemical binding]; other site
425104009687	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
425104009688	FOG: CBS domain [General function prediction only]; Region: COG0517
425104009689	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
425104009690	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
425104009691	Substrate binding site; other site
425104009692	metal-binding site
425104009693	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
425104009694	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
425104009695	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
425104009696	ligand binding site; other site
425104009697	tetramer interface; other site
425104009698	flagellin modification protein A; Provisional; Region: PRK09186
425104009699	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104009700	NAD(P) binding site [chemical binding]; other site
425104009701	active site
425104009702	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
425104009703	trimer interface [polypeptide binding]; other site
425104009704	active site
425104009705	substrate binding site [chemical binding]; other site
425104009706	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
425104009707	CoA binding site [chemical binding]; other site
425104009708	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
425104009709	Tetratricopeptide repeat; Region: TPR_16; pfam13432
425104009710	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104009711	TPR motif; other site
425104009712	binding surface
425104009713	Protein of unknown function (DUF2947); Region: DUF2947; pfam11163
425104009714	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104009715	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104009716	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
425104009717	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104009718	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104009719	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104009720	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104009721	Protein export membrane protein; Region: SecD_SecF; cl14618
425104009722	Cache domain; Region: Cache_1; pfam02743
425104009723	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104009724	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104009725	dimer interface [polypeptide binding]; other site
425104009726	putative CheW interface [polypeptide binding]; other site
425104009727	TfoX C-terminal domain; Region: TfoX_C; pfam04994
425104009728	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
425104009729	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
425104009730	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
425104009731	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
425104009732	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
425104009733	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
425104009734	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
425104009735	dimerization interface [polypeptide binding]; other site
425104009736	ATP binding site [chemical binding]; other site
425104009737	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
425104009738	dimerization interface [polypeptide binding]; other site
425104009739	ATP binding site [chemical binding]; other site
425104009740	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
425104009741	putative active site [active]
425104009742	catalytic triad [active]
425104009743	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
425104009744	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104009745	substrate binding pocket [chemical binding]; other site
425104009746	membrane-bound complex binding site; other site
425104009747	hinge residues; other site
425104009748	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
425104009749	N-acetyl-D-glucosamine binding site [chemical binding]; other site
425104009750	catalytic residue [active]
425104009751	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
425104009752	nucleoside/Zn binding site; other site
425104009753	dimer interface [polypeptide binding]; other site
425104009754	catalytic motif [active]
425104009755	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104009756	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104009757	metal binding site [ion binding]; metal-binding site
425104009758	active site
425104009759	I-site; other site
425104009760	GMP synthase; Reviewed; Region: guaA; PRK00074
425104009761	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
425104009762	AMP/PPi binding site [chemical binding]; other site
425104009763	candidate oxyanion hole; other site
425104009764	catalytic triad [active]
425104009765	potential glutamine specificity residues [chemical binding]; other site
425104009766	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
425104009767	ATP Binding subdomain [chemical binding]; other site
425104009768	Ligand Binding sites [chemical binding]; other site
425104009769	Dimerization subdomain; other site
425104009770	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
425104009771	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
425104009772	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
425104009773	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
425104009774	active site
425104009775	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
425104009776	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
425104009777	generic binding surface II; other site
425104009778	generic binding surface I; other site
425104009779	DsrE/DsrF-like family; Region: DrsE; cl00672
425104009780	Methyltransferase domain; Region: Methyltransf_23; pfam13489
425104009781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104009782	S-adenosylmethionine binding site [chemical binding]; other site
425104009783	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
425104009784	dimerization interface [polypeptide binding]; other site
425104009785	putative DNA binding site [nucleotide binding]; other site
425104009786	putative Zn2+ binding site [ion binding]; other site
425104009787	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
425104009788	active site residue [active]
425104009789	Methyltransferase domain; Region: Methyltransf_23; pfam13489
425104009790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104009791	S-adenosylmethionine binding site [chemical binding]; other site
425104009792	prolyl-tRNA synthetase; Provisional; Region: PRK09194
425104009793	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
425104009794	dimer interface [polypeptide binding]; other site
425104009795	motif 1; other site
425104009796	active site
425104009797	motif 2; other site
425104009798	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
425104009799	putative deacylase active site [active]
425104009800	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
425104009801	active site
425104009802	motif 3; other site
425104009803	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
425104009804	anticodon binding site; other site
425104009805	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
425104009806	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
425104009807	acyl-activating enzyme (AAE) consensus motif; other site
425104009808	active site
425104009809	AMP binding site [chemical binding]; other site
425104009810	CoA binding site [chemical binding]; other site
425104009811	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
425104009812	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
425104009813	Walker A/P-loop; other site
425104009814	ATP binding site [chemical binding]; other site
425104009815	Q-loop/lid; other site
425104009816	ABC transporter signature motif; other site
425104009817	Walker B; other site
425104009818	D-loop; other site
425104009819	H-loop/switch region; other site
425104009820	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
425104009821	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
425104009822	putative ligand binding site [chemical binding]; other site
425104009823	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
425104009824	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
425104009825	TM-ABC transporter signature motif; other site
425104009826	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
425104009827	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
425104009828	TM-ABC transporter signature motif; other site
425104009829	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
425104009830	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
425104009831	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
425104009832	acyl-activating enzyme (AAE) consensus motif; other site
425104009833	putative AMP binding site [chemical binding]; other site
425104009834	putative active site [active]
425104009835	putative CoA binding site [chemical binding]; other site
425104009836	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
425104009837	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
425104009838	Walker A/P-loop; other site
425104009839	ATP binding site [chemical binding]; other site
425104009840	Q-loop/lid; other site
425104009841	ABC transporter signature motif; other site
425104009842	Walker B; other site
425104009843	D-loop; other site
425104009844	H-loop/switch region; other site
425104009845	Porin subfamily; Region: Porin_2; pfam02530
425104009846	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
425104009847	Na binding site [ion binding]; other site
425104009848	PAS fold; Region: PAS_7; pfam12860
425104009849	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104009850	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104009851	ATP binding site [chemical binding]; other site
425104009852	Mg2+ binding site [ion binding]; other site
425104009853	G-X-G motif; other site
425104009854	Response regulator receiver domain; Region: Response_reg; pfam00072
425104009855	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009856	active site
425104009857	phosphorylation site [posttranslational modification]
425104009858	intermolecular recognition site; other site
425104009859	dimerization interface [polypeptide binding]; other site
425104009860	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
425104009861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104009862	active site
425104009863	phosphorylation site [posttranslational modification]
425104009864	intermolecular recognition site; other site
425104009865	dimerization interface [polypeptide binding]; other site
425104009866	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104009867	DNA binding residues [nucleotide binding]
425104009868	dimerization interface [polypeptide binding]; other site
425104009869	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
425104009870	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
425104009871	nucleophile elbow; other site
425104009872	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
425104009873	oxyanion hole [active]
425104009874	active site
425104009875	catalytic triad [active]
425104009876	putative cation:proton antiport protein; Provisional; Region: PRK10669
425104009877	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
425104009878	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
425104009879	TrkA-N domain; Region: TrkA_N; pfam02254
425104009880	TrkA-C domain; Region: TrkA_C; pfam02080
425104009881	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104009882	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104009883	metal binding site [ion binding]; metal-binding site
425104009884	active site
425104009885	I-site; other site
425104009886	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
425104009887	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
425104009888	Ligand Binding Site [chemical binding]; other site
425104009889	TilS substrate binding domain; Region: TilS; pfam09179
425104009890	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
425104009891	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
425104009892	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
425104009893	putative active site [active]
425104009894	putative PHP Thumb interface [polypeptide binding]; other site
425104009895	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
425104009896	generic binding surface II; other site
425104009897	generic binding surface I; other site
425104009898	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
425104009899	RNA/DNA hybrid binding site [nucleotide binding]; other site
425104009900	active site
425104009901	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
425104009902	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
425104009903	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
425104009904	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
425104009905	active site
425104009906	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
425104009907	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
425104009908	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
425104009909	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
425104009910	trimer interface [polypeptide binding]; other site
425104009911	active site
425104009912	UDP-GlcNAc binding site [chemical binding]; other site
425104009913	lipid binding site [chemical binding]; lipid-binding site
425104009914	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
425104009915	periplasmic chaperone; Provisional; Region: PRK10780
425104009916	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
425104009917	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
425104009918	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
425104009919	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
425104009920	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
425104009921	Surface antigen; Region: Bac_surface_Ag; pfam01103
425104009922	zinc metallopeptidase RseP; Provisional; Region: PRK10779
425104009923	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
425104009924	active site
425104009925	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
425104009926	protein binding site [polypeptide binding]; other site
425104009927	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
425104009928	protein binding site [polypeptide binding]; other site
425104009929	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
425104009930	putative substrate binding region [chemical binding]; other site
425104009931	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
425104009932	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
425104009933	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
425104009934	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
425104009935	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
425104009936	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
425104009937	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
425104009938	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
425104009939	catalytic residue [active]
425104009940	putative FPP diphosphate  binding site; other site
425104009941	putative FPP binding hydrophobic cleft; other site
425104009942	dimer interface [polypeptide binding]; other site
425104009943	putative IPP diphosphate binding site; other site
425104009944	ribosome recycling factor; Reviewed; Region: frr; PRK00083
425104009945	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
425104009946	hinge region; other site
425104009947	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
425104009948	putative nucleotide binding site [chemical binding]; other site
425104009949	uridine monophosphate binding site [chemical binding]; other site
425104009950	homohexameric interface [polypeptide binding]; other site
425104009951	elongation factor Ts; Provisional; Region: tsf; PRK09377
425104009952	UBA/TS-N domain; Region: UBA; pfam00627
425104009953	Elongation factor TS; Region: EF_TS; pfam00889
425104009954	Elongation factor TS; Region: EF_TS; pfam00889
425104009955	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
425104009956	rRNA interaction site [nucleotide binding]; other site
425104009957	S8 interaction site; other site
425104009958	putative laminin-1 binding site; other site
425104009959	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
425104009960	active site
425104009961	PII uridylyl-transferase; Provisional; Region: PRK05007
425104009962	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
425104009963	metal binding triad; other site
425104009964	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
425104009965	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104009966	Zn2+ binding site [ion binding]; other site
425104009967	Mg2+ binding site [ion binding]; other site
425104009968	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
425104009969	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
425104009970	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
425104009971	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
425104009972	trimer interface [polypeptide binding]; other site
425104009973	active site
425104009974	substrate binding site [chemical binding]; other site
425104009975	CoA binding site [chemical binding]; other site
425104009976	Protein of unknown function (DUF3718); Region: DUF3718; pfam12514
425104009977	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
425104009978	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
425104009979	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
425104009980	putative active site [active]
425104009981	putative substrate binding site [chemical binding]; other site
425104009982	putative cosubstrate binding site; other site
425104009983	catalytic site [active]
425104009984	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
425104009985	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
425104009986	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
425104009987	active site turn [active]
425104009988	phosphorylation site [posttranslational modification]
425104009989	flavodoxin; Provisional; Region: PRK08105
425104009990	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
425104009991	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
425104009992	probable active site [active]
425104009993	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
425104009994	Protein of unknown function (DUF3549); Region: DUF3549; pfam12069
425104009995	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
425104009996	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104009997	Coenzyme A binding pocket [chemical binding]; other site
425104009998	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
425104009999	Protein of unknown function (DUF3192); Region: DUF3192; pfam11399
425104010000	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071
425104010001	SecY interacting protein Syd; Provisional; Region: PRK04968
425104010002	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
425104010003	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
425104010004	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
425104010005	catalase/peroxidase HPI; Region: cat_per_HPI; TIGR00198
425104010006	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
425104010007	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104010008	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
425104010009	putative substrate binding pocket [chemical binding]; other site
425104010010	putative dimerization interface [polypeptide binding]; other site
425104010011	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
425104010012	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104010013	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
425104010014	putative substrate binding pocket [chemical binding]; other site
425104010015	putative dimerization interface [polypeptide binding]; other site
425104010016	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
425104010017	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
425104010018	SCP-2 sterol transfer family; Region: SCP2; pfam02036
425104010019	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
425104010020	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
425104010021	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104010022	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104010023	dimer interface [polypeptide binding]; other site
425104010024	putative CheW interface [polypeptide binding]; other site
425104010025	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104010026	Zn2+ binding site [ion binding]; other site
425104010027	Mg2+ binding site [ion binding]; other site
425104010028	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104010029	Zn2+ binding site [ion binding]; other site
425104010030	Mg2+ binding site [ion binding]; other site
425104010031	RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959
425104010032	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
425104010033	Predicted permeases [General function prediction only]; Region: COG0701
425104010034	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
425104010035	catalytic residues [active]
425104010036	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
425104010037	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
425104010038	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
425104010039	Walker A/P-loop; other site
425104010040	ATP binding site [chemical binding]; other site
425104010041	Q-loop/lid; other site
425104010042	ABC transporter signature motif; other site
425104010043	Walker B; other site
425104010044	D-loop; other site
425104010045	H-loop/switch region; other site
425104010046	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
425104010047	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
425104010048	FtsX-like permease family; Region: FtsX; pfam02687
425104010049	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
425104010050	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
425104010051	FtsX-like permease family; Region: FtsX; pfam02687
425104010052	elongation factor G; Reviewed; Region: PRK13351
425104010053	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
425104010054	G1 box; other site
425104010055	putative GEF interaction site [polypeptide binding]; other site
425104010056	GTP/Mg2+ binding site [chemical binding]; other site
425104010057	Switch I region; other site
425104010058	G2 box; other site
425104010059	G3 box; other site
425104010060	Switch II region; other site
425104010061	G4 box; other site
425104010062	G5 box; other site
425104010063	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
425104010064	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
425104010065	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
425104010066	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
425104010067	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
425104010068	active site
425104010069	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
425104010070	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
425104010071	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
425104010072	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
425104010073	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
425104010074	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
425104010075	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
425104010076	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
425104010077	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
425104010078	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
425104010079	putative NADP binding site [chemical binding]; other site
425104010080	active site
425104010081	Acyl transferase domain; Region: Acyl_transf_1; cl08282
425104010082	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
425104010083	3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050
425104010084	active site
425104010085	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
425104010086	active site
425104010087	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
425104010088	active site 2 [active]
425104010089	dimer interface [polypeptide binding]; other site
425104010090	active site 1 [active]
425104010091	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
425104010092	active site 1 [active]
425104010093	dimer interface [polypeptide binding]; other site
425104010094	active site 2 [active]
425104010095	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
425104010096	FMN binding site [chemical binding]; other site
425104010097	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
425104010098	substrate binding site [chemical binding]; other site
425104010099	putative catalytic residue [active]
425104010100	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
425104010101	TPR repeat; Region: TPR_11; pfam13414
425104010102	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104010103	TPR motif; other site
425104010104	binding surface
425104010105	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
425104010106	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
425104010107	transmembrane helices; other site
425104010108	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
425104010109	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
425104010110	ligand binding site [chemical binding]; other site
425104010111	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104010112	ATP binding site [chemical binding]; other site
425104010113	Mg2+ binding site [ion binding]; other site
425104010114	G-X-G motif; other site
425104010115	Response regulator receiver domain; Region: Response_reg; pfam00072
425104010116	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104010117	active site
425104010118	phosphorylation site [posttranslational modification]
425104010119	intermolecular recognition site; other site
425104010120	dimerization interface [polypeptide binding]; other site
425104010121	RecX family; Region: RecX; pfam02631
425104010122	RecX family; Region: RecX; pfam02631
425104010123	YcaO domain protein; Region: TIGR03549
425104010124	OsmC-like protein; Region: OsmC; pfam02566
425104010125	YcaO-like family; Region: YcaO; pfam02624
425104010126	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
425104010127	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104010128	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104010129	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
425104010130	E3 interaction surface; other site
425104010131	lipoyl attachment site [posttranslational modification]; other site
425104010132	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104010133	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104010134	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104010135	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104010136	dimerization interface [polypeptide binding]; other site
425104010137	putative effector binding pocket; other site
425104010138	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
425104010139	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
425104010140	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104010141	catalytic residue [active]
425104010142	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104010143	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
425104010144	putative active site [active]
425104010145	heme pocket [chemical binding]; other site
425104010146	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104010147	putative active site [active]
425104010148	heme pocket [chemical binding]; other site
425104010149	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104010150	PAS domain; Region: PAS_9; pfam13426
425104010151	putative active site [active]
425104010152	heme pocket [chemical binding]; other site
425104010153	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104010154	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104010155	metal binding site [ion binding]; metal-binding site
425104010156	active site
425104010157	I-site; other site
425104010158	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104010159	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
425104010160	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104010161	N-terminal plug; other site
425104010162	ligand-binding site [chemical binding]; other site
425104010163	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
425104010164	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
425104010165	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
425104010166	active site
425104010167	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
425104010168	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104010169	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104010170	dimerization interface [polypeptide binding]; other site
425104010171	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
425104010172	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
425104010173	substrate binding pocket [chemical binding]; other site
425104010174	carnitine operon protein CaiE; Provisional; Region: PRK13627
425104010175	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
425104010176	putative trimer interface [polypeptide binding]; other site
425104010177	putative metal binding site [ion binding]; other site
425104010178	enoyl-CoA hydratase; Region: PLN02864
425104010179	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
425104010180	active site 2 [active]
425104010181	active site 1 [active]
425104010182	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
425104010183	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
425104010184	substrate binding site [chemical binding]; other site
425104010185	oxyanion hole (OAH) forming residues; other site
425104010186	trimer interface [polypeptide binding]; other site
425104010187	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
425104010188	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
425104010189	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
425104010190	acyl-activating enzyme (AAE) consensus motif; other site
425104010191	putative AMP binding site [chemical binding]; other site
425104010192	putative active site [active]
425104010193	putative CoA binding site [chemical binding]; other site
425104010194	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
425104010195	CoA-transferase family III; Region: CoA_transf_3; pfam02515
425104010196	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
425104010197	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
425104010198	active site
425104010199	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
425104010200	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
425104010201	Ligand binding site [chemical binding]; other site
425104010202	Electron transfer flavoprotein domain; Region: ETF; pfam01012
425104010203	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
425104010204	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
425104010205	Ligand binding site [chemical binding]; other site
425104010206	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
425104010207	putative oxidoreductase FixC; Provisional; Region: PRK10157
425104010208	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
425104010209	ferredoxin-like protein FixX; Provisional; Region: PRK15449
425104010210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104010211	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
425104010212	putative substrate translocation pore; other site
425104010213	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
425104010214	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104010215	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104010216	dimerization interface [polypeptide binding]; other site
425104010217	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104010218	dimer interface [polypeptide binding]; other site
425104010219	putative CheW interface [polypeptide binding]; other site
425104010220	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104010221	transcriptional activator TtdR; Provisional; Region: PRK09801
425104010222	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104010223	putative effector binding pocket; other site
425104010224	dimerization interface [polypeptide binding]; other site
425104010225	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
425104010226	Uncharacterized conserved protein [Function unknown]; Region: COG2128
425104010227	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
425104010228	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104010229	Predicted membrane protein [Function unknown]; Region: COG3212
425104010230	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
425104010231	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
425104010232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104010233	active site
425104010234	phosphorylation site [posttranslational modification]
425104010235	intermolecular recognition site; other site
425104010236	dimerization interface [polypeptide binding]; other site
425104010237	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104010238	DNA binding site [nucleotide binding]
425104010239	sensor protein PhoQ; Provisional; Region: PRK10815
425104010240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104010241	ATP binding site [chemical binding]; other site
425104010242	Mg2+ binding site [ion binding]; other site
425104010243	G-X-G motif; other site
425104010244	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
425104010245	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
425104010246	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
425104010247	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
425104010248	ligand binding site [chemical binding]; other site
425104010249	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
425104010250	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
425104010251	tetramer interface [polypeptide binding]; other site
425104010252	heme binding pocket [chemical binding]; other site
425104010253	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
425104010254	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
425104010255	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104010256	Sulphur transport; Region: Sulf_transp; pfam04143
425104010257	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
425104010258	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
425104010259	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104010260	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104010261	dimerization interface [polypeptide binding]; other site
425104010262	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104010263	dimer interface [polypeptide binding]; other site
425104010264	putative CheW interface [polypeptide binding]; other site
425104010265	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
425104010266	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
425104010267	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
425104010268	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
425104010269	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
425104010270	active site
425104010271	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
425104010272	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104010273	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
425104010274	heme-binding residues [chemical binding]; other site
425104010275	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
425104010276	Helix-turn-helix domain; Region: HTH_18; pfam12833
425104010277	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104010278	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104010279	dimerization interface [polypeptide binding]; other site
425104010280	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104010281	PAS domain; Region: PAS_9; pfam13426
425104010282	putative active site [active]
425104010283	heme pocket [chemical binding]; other site
425104010284	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104010285	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104010286	metal binding site [ion binding]; metal-binding site
425104010287	active site
425104010288	I-site; other site
425104010289	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104010290	putative metal dependent hydrolase; Provisional; Region: PRK11598
425104010291	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
425104010292	Sulfatase; Region: Sulfatase; pfam00884
425104010293	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
425104010294	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
425104010295	RNA binding surface [nucleotide binding]; other site
425104010296	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
425104010297	active site
425104010298	uracil binding [chemical binding]; other site
425104010299	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
425104010300	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
425104010301	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
425104010302	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
425104010303	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
425104010304	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
425104010305	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104010306	Zn2+ binding site [ion binding]; other site
425104010307	Mg2+ binding site [ion binding]; other site
425104010308	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104010309	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104010310	metal binding site [ion binding]; metal-binding site
425104010311	active site
425104010312	I-site; other site
425104010313	purine nucleoside phosphorylase; Provisional; Region: PRK13374
425104010314	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
425104010315	putative transporter; Provisional; Region: PRK03699
425104010316	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104010317	putative substrate translocation pore; other site
425104010318	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
425104010319	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
425104010320	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
425104010321	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
425104010322	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
425104010323	Helix-turn-helix domain; Region: HTH_18; pfam12833
425104010324	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104010325	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
425104010326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104010327	putative substrate translocation pore; other site
425104010328	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
425104010329	DNA-binding site [nucleotide binding]; DNA binding site
425104010330	RNA-binding motif; other site
425104010331	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
425104010332	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
425104010333	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104010334	active site
425104010335	phosphorylation site [posttranslational modification]
425104010336	intermolecular recognition site; other site
425104010337	dimerization interface [polypeptide binding]; other site
425104010338	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104010339	DNA binding site [nucleotide binding]
425104010340	HAMP domain; Region: HAMP; pfam00672
425104010341	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104010342	dimer interface [polypeptide binding]; other site
425104010343	phosphorylation site [posttranslational modification]
425104010344	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104010345	ATP binding site [chemical binding]; other site
425104010346	Mg2+ binding site [ion binding]; other site
425104010347	G-X-G motif; other site
425104010348	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
425104010349	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
425104010350	homodimer interface [polypeptide binding]; other site
425104010351	substrate-cofactor binding pocket; other site
425104010352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104010353	catalytic residue [active]
425104010354	GAF domain; Region: GAF; pfam01590
425104010355	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104010356	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104010357	metal binding site [ion binding]; metal-binding site
425104010358	active site
425104010359	I-site; other site
425104010360	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104010361	Protein of unknown function, DUF599; Region: DUF599; pfam04654
425104010362	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
425104010363	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
425104010364	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
425104010365	Active site serine [active]
425104010366	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
425104010367	active site
425104010368	active site
425104010369	FOG: PKD repeat [General function prediction only]; Region: COG3291
425104010370	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
425104010371	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
425104010372	Interdomain contacts; other site
425104010373	Cytokine receptor motif; other site
425104010374	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
425104010375	active site
425104010376	catalytic residues [active]
425104010377	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
425104010378	PA/protease or protease-like domain interface [polypeptide binding]; other site
425104010379	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
425104010380	catalytic residues [active]
425104010381	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
425104010382	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
425104010383	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
425104010384	C-terminal domain interface [polypeptide binding]; other site
425104010385	GSH binding site (G-site) [chemical binding]; other site
425104010386	dimer interface [polypeptide binding]; other site
425104010387	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
425104010388	N-terminal domain interface [polypeptide binding]; other site
425104010389	putative dimer interface [polypeptide binding]; other site
425104010390	active site
425104010391	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104010392	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104010393	substrate binding pocket [chemical binding]; other site
425104010394	membrane-bound complex binding site; other site
425104010395	hinge residues; other site
425104010396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104010397	Methyltransferase domain; Region: Methyltransf_31; pfam13847
425104010398	S-adenosylmethionine binding site [chemical binding]; other site
425104010399	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
425104010400	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104010401	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
425104010402	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
425104010403	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104010404	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104010405	metal binding site [ion binding]; metal-binding site
425104010406	active site
425104010407	I-site; other site
425104010408	YfaZ precursor; Region: YfaZ; pfam07437
425104010409	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
425104010410	catalytic residues [active]
425104010411	dimer interface [polypeptide binding]; other site
425104010412	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
425104010413	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
425104010414	active site
425104010415	Zn binding site [ion binding]; other site
425104010416	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
425104010417	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
425104010418	PBP superfamily domain; Region: PBP_like_2; cl17296
425104010419	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
425104010420	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
425104010421	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104010422	putative active site [active]
425104010423	heme pocket [chemical binding]; other site
425104010424	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104010425	dimer interface [polypeptide binding]; other site
425104010426	phosphorylation site [posttranslational modification]
425104010427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104010428	ATP binding site [chemical binding]; other site
425104010429	Mg2+ binding site [ion binding]; other site
425104010430	G-X-G motif; other site
425104010431	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
425104010432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104010433	active site
425104010434	phosphorylation site [posttranslational modification]
425104010435	intermolecular recognition site; other site
425104010436	dimerization interface [polypeptide binding]; other site
425104010437	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104010438	DNA binding site [nucleotide binding]
425104010439	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
425104010440	trimer interface [polypeptide binding]; other site
425104010441	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
425104010442	eyelet of channel; other site
425104010443	recombination associated protein; Reviewed; Region: rdgC; PRK00321
425104010444	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
425104010445	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
425104010446	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
425104010447	protein binding site [polypeptide binding]; other site
425104010448	Tetratricopeptide repeat; Region: TPR_12; pfam13424
425104010449	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104010450	TPR motif; other site
425104010451	binding surface
425104010452	Tetratricopeptide repeat; Region: TPR_12; pfam13424
425104010453	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104010454	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104010455	metal binding site [ion binding]; metal-binding site
425104010456	active site
425104010457	I-site; other site
425104010458	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
425104010459	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
425104010460	flap endonuclease-like protein; Provisional; Region: PRK09482
425104010461	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
425104010462	active site
425104010463	metal binding site 1 [ion binding]; metal-binding site
425104010464	putative 5' ssDNA interaction site; other site
425104010465	metal binding site 3; metal-binding site
425104010466	metal binding site 2 [ion binding]; metal-binding site
425104010467	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
425104010468	putative DNA binding site [nucleotide binding]; other site
425104010469	putative metal binding site [ion binding]; other site
425104010470	Protein of unknown function (DUF3192); Region: DUF3192; pfam11399
425104010471	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
425104010472	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
425104010473	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
425104010474	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
425104010475	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
425104010476	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104010477	isocitrate dehydrogenase; Provisional; Region: PRK08997
425104010478	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
425104010479	FtsJ-like methyltransferase; Region: FtsJ; cl17430
425104010480	Protein of unknown function (DUF423); Region: DUF423; pfam04241
425104010481	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
425104010482	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
425104010483	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104010484	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
425104010485	dimerization interface [polypeptide binding]; other site
425104010486	substrate binding pocket [chemical binding]; other site
425104010487	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
425104010488	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
425104010489	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
425104010490	Ligand Binding Site [chemical binding]; other site
425104010491	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
425104010492	active site residue [active]
425104010493	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
425104010494	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
425104010495	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
425104010496	ligand binding site [chemical binding]; other site
425104010497	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
425104010498	flagellar motor protein PomA; Reviewed; Region: PRK08990
425104010499	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
425104010500	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
425104010501	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
425104010502	substrate binding pocket [chemical binding]; other site
425104010503	chain length determination region; other site
425104010504	substrate-Mg2+ binding site; other site
425104010505	catalytic residues [active]
425104010506	aspartate-rich region 1; other site
425104010507	active site lid residues [active]
425104010508	aspartate-rich region 2; other site
425104010509	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
425104010510	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
425104010511	TPP-binding site; other site
425104010512	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
425104010513	PYR/PP interface [polypeptide binding]; other site
425104010514	dimer interface [polypeptide binding]; other site
425104010515	TPP binding site [chemical binding]; other site
425104010516	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
425104010517	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
425104010518	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
425104010519	dimer interface [polypeptide binding]; other site
425104010520	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
425104010521	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
425104010522	LabA_like proteins; Region: LabA_like; cd06167
425104010523	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
425104010524	putative metal binding site [ion binding]; other site
425104010525	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
425104010526	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
425104010527	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
425104010528	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
425104010529	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
425104010530	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
425104010531	DEAD-like helicases superfamily; Region: DEXDc; smart00487
425104010532	ATP binding site [chemical binding]; other site
425104010533	Mg++ binding site [ion binding]; other site
425104010534	motif III; other site
425104010535	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104010536	nucleotide binding region [chemical binding]; other site
425104010537	ATP-binding site [chemical binding]; other site
425104010538	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
425104010539	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104010540	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
425104010541	putative active site [active]
425104010542	heme pocket [chemical binding]; other site
425104010543	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
425104010544	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104010545	putative active site [active]
425104010546	heme pocket [chemical binding]; other site
425104010547	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104010548	putative active site [active]
425104010549	heme pocket [chemical binding]; other site
425104010550	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104010551	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104010552	metal binding site [ion binding]; metal-binding site
425104010553	active site
425104010554	I-site; other site
425104010555	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104010556	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104010557	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
425104010558	active site
425104010559	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104010560	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104010561	metal binding site [ion binding]; metal-binding site
425104010562	active site
425104010563	I-site; other site
425104010564	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104010565	HDOD domain; Region: HDOD; pfam08668
425104010566	putative protease; Provisional; Region: PRK15452
425104010567	Peptidase family U32; Region: Peptidase_U32; pfam01136
425104010568	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
425104010569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104010570	putative substrate translocation pore; other site
425104010571	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104010572	PAS domain; Region: PAS_9; pfam13426
425104010573	putative active site [active]
425104010574	heme pocket [chemical binding]; other site
425104010575	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104010576	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104010577	metal binding site [ion binding]; metal-binding site
425104010578	active site
425104010579	I-site; other site
425104010580	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104010581	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
425104010582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104010583	active site
425104010584	phosphorylation site [posttranslational modification]
425104010585	intermolecular recognition site; other site
425104010586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104010587	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
425104010588	active site
425104010589	phosphorylation site [posttranslational modification]
425104010590	intermolecular recognition site; other site
425104010591	dimerization interface [polypeptide binding]; other site
425104010592	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104010593	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104010594	metal binding site [ion binding]; metal-binding site
425104010595	active site
425104010596	I-site; other site
425104010597	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
425104010598	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
425104010599	active site
425104010600	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
425104010601	putative active site [active]
425104010602	putative substrate binding site [chemical binding]; other site
425104010603	putative cosubstrate binding site; other site
425104010604	catalytic site [active]
425104010605	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
425104010606	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
425104010607	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
425104010608	substrate binding site [chemical binding]; other site
425104010609	oxyanion hole (OAH) forming residues; other site
425104010610	trimer interface [polypeptide binding]; other site
425104010611	SCP-2 sterol transfer family; Region: SCP2; cl01225
425104010612	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
425104010613	Peptidase family U32; Region: Peptidase_U32; pfam01136
425104010614	putative protease; Provisional; Region: PRK15447
425104010615	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
425104010616	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
425104010617	Nucleoside recognition; Region: Gate; pfam07670
425104010618	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
425104010619	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
425104010620	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
425104010621	PAS fold; Region: PAS_3; pfam08447
425104010622	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104010623	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104010624	ATP binding site [chemical binding]; other site
425104010625	Mg2+ binding site [ion binding]; other site
425104010626	G-X-G motif; other site
425104010627	FOG: CBS domain [General function prediction only]; Region: COG0517
425104010628	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_24; cd04637
425104010629	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
425104010630	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
425104010631	Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796
425104010632	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
425104010633	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
425104010634	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
425104010635	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
425104010636	molybdopterin cofactor binding site [chemical binding]; other site
425104010637	substrate binding site [chemical binding]; other site
425104010638	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
425104010639	molybdopterin cofactor binding site; other site
425104010640	chaperone protein TorD; Validated; Region: torD; PRK04976
425104010641	Protein of unknown function (DUF3624); Region: DUF3624; pfam12292
425104010642	DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625
425104010643	putative ligand binding site [chemical binding]; other site
425104010644	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
425104010645	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
425104010646	ATP binding site [chemical binding]; other site
425104010647	Mg++ binding site [ion binding]; other site
425104010648	motif III; other site
425104010649	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104010650	nucleotide binding region [chemical binding]; other site
425104010651	ATP-binding site [chemical binding]; other site
425104010652	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
425104010653	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104010654	dimer interface [polypeptide binding]; other site
425104010655	phosphorylation site [posttranslational modification]
425104010656	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104010657	ATP binding site [chemical binding]; other site
425104010658	Mg2+ binding site [ion binding]; other site
425104010659	G-X-G motif; other site
425104010660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104010661	active site
425104010662	phosphorylation site [posttranslational modification]
425104010663	intermolecular recognition site; other site
425104010664	dimerization interface [polypeptide binding]; other site
425104010665	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
425104010666	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
425104010667	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
425104010668	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
425104010669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104010670	active site
425104010671	phosphorylation site [posttranslational modification]
425104010672	intermolecular recognition site; other site
425104010673	dimerization interface [polypeptide binding]; other site
425104010674	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104010675	DNA binding site [nucleotide binding]
425104010676	PilZ domain; Region: PilZ; pfam07238
425104010677	DNA repair protein RadA; Provisional; Region: PRK11823
425104010678	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
425104010679	Walker A motif; other site
425104010680	ATP binding site [chemical binding]; other site
425104010681	Walker B motif; other site
425104010682	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
425104010683	PilZ domain; Region: PilZ; pfam07238
425104010684	PilZ domain; Region: PilZ; pfam07238
425104010685	Serine hydrolase (FSH1); Region: FSH1; pfam03959
425104010686	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
425104010687	phosphoserine phosphatase SerB; Region: serB; TIGR00338
425104010688	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104010689	motif II; other site
425104010690	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
425104010691	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
425104010692	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
425104010693	phosphopentomutase; Provisional; Region: PRK05362
425104010694	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
425104010695	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
425104010696	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
425104010697	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
425104010698	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
425104010699	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
425104010700	intersubunit interface [polypeptide binding]; other site
425104010701	active site
425104010702	catalytic residue [active]
425104010703	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
425104010704	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
425104010705	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
425104010706	Nucleoside recognition; Region: Gate; pfam07670
425104010707	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
425104010708	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
425104010709	active site
425104010710	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
425104010711	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
425104010712	G1 box; other site
425104010713	putative GEF interaction site [polypeptide binding]; other site
425104010714	GTP/Mg2+ binding site [chemical binding]; other site
425104010715	Switch I region; other site
425104010716	G2 box; other site
425104010717	G3 box; other site
425104010718	Switch II region; other site
425104010719	G4 box; other site
425104010720	G5 box; other site
425104010721	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
425104010722	lipoprotein NlpI; Provisional; Region: PRK11189
425104010723	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104010724	binding surface
425104010725	TPR motif; other site
425104010726	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
425104010727	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
425104010728	RNase E interface [polypeptide binding]; other site
425104010729	trimer interface [polypeptide binding]; other site
425104010730	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
425104010731	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
425104010732	RNase E interface [polypeptide binding]; other site
425104010733	trimer interface [polypeptide binding]; other site
425104010734	active site
425104010735	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
425104010736	putative nucleic acid binding region [nucleotide binding]; other site
425104010737	G-X-X-G motif; other site
425104010738	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
425104010739	RNA binding site [nucleotide binding]; other site
425104010740	domain interface; other site
425104010741	biofilm formation regulator HmsP; Provisional; Region: PRK11829
425104010742	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104010743	metal binding site [ion binding]; metal-binding site
425104010744	active site
425104010745	I-site; other site
425104010746	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104010747	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
425104010748	16S/18S rRNA binding site [nucleotide binding]; other site
425104010749	S13e-L30e interaction site [polypeptide binding]; other site
425104010750	25S rRNA binding site [nucleotide binding]; other site
425104010751	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
425104010752	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
425104010753	RNA binding site [nucleotide binding]; other site
425104010754	active site
425104010755	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
425104010756	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
425104010757	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
425104010758	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
425104010759	translation initiation factor IF-2; Region: IF-2; TIGR00487
425104010760	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
425104010761	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
425104010762	G1 box; other site
425104010763	putative GEF interaction site [polypeptide binding]; other site
425104010764	GTP/Mg2+ binding site [chemical binding]; other site
425104010765	Switch I region; other site
425104010766	G2 box; other site
425104010767	G3 box; other site
425104010768	Switch II region; other site
425104010769	G4 box; other site
425104010770	G5 box; other site
425104010771	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
425104010772	Translation-initiation factor 2; Region: IF-2; pfam11987
425104010773	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
425104010774	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
425104010775	NusA N-terminal domain; Region: NusA_N; pfam08529
425104010776	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
425104010777	RNA binding site [nucleotide binding]; other site
425104010778	homodimer interface [polypeptide binding]; other site
425104010779	NusA-like KH domain; Region: KH_5; pfam13184
425104010780	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
425104010781	G-X-X-G motif; other site
425104010782	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
425104010783	ribosome maturation protein RimP; Reviewed; Region: PRK00092
425104010784	Sm and related proteins; Region: Sm_like; cl00259
425104010785	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
425104010786	putative oligomer interface [polypeptide binding]; other site
425104010787	putative RNA binding site [nucleotide binding]; other site
425104010788	Preprotein translocase SecG subunit; Region: SecG; pfam03840
425104010789	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
425104010790	triosephosphate isomerase; Provisional; Region: PRK14567
425104010791	substrate binding site [chemical binding]; other site
425104010792	dimer interface [polypeptide binding]; other site
425104010793	catalytic triad [active]
425104010794	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
425104010795	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
425104010796	active site
425104010797	substrate binding site [chemical binding]; other site
425104010798	metal binding site [ion binding]; metal-binding site
425104010799	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
425104010800	dihydropteroate synthase; Region: DHPS; TIGR01496
425104010801	substrate binding pocket [chemical binding]; other site
425104010802	dimer interface [polypeptide binding]; other site
425104010803	inhibitor binding site; inhibition site
425104010804	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
425104010805	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104010806	Walker A motif; other site
425104010807	ATP binding site [chemical binding]; other site
425104010808	Walker B motif; other site
425104010809	arginine finger; other site
425104010810	Peptidase family M41; Region: Peptidase_M41; pfam01434
425104010811	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
425104010812	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104010813	S-adenosylmethionine binding site [chemical binding]; other site
425104010814	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
425104010815	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13021
425104010816	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
425104010817	Protein export membrane protein; Region: SecD_SecF; pfam02355
425104010818	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933
425104010819	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
425104010820	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
425104010821	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
425104010822	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
425104010823	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
425104010824	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
425104010825	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
425104010826	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
425104010827	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
425104010828	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
425104010829	ATP-grasp domain; Region: ATP-grasp_4; cl17255
425104010830	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
425104010831	IMP binding site; other site
425104010832	dimer interface [polypeptide binding]; other site
425104010833	interdomain contacts; other site
425104010834	partial ornithine binding site; other site
425104010835	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
425104010836	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
425104010837	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
425104010838	catalytic site [active]
425104010839	subunit interface [polypeptide binding]; other site
425104010840	dihydrodipicolinate reductase; Provisional; Region: PRK00048
425104010841	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
425104010842	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
425104010843	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
425104010844	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
425104010845	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
425104010846	Peptidase family M48; Region: Peptidase_M48; pfam01435
425104010847	chaperone protein DnaJ; Provisional; Region: PRK10767
425104010848	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
425104010849	HSP70 interaction site [polypeptide binding]; other site
425104010850	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
425104010851	substrate binding site [polypeptide binding]; other site
425104010852	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
425104010853	Zn binding sites [ion binding]; other site
425104010854	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
425104010855	dimer interface [polypeptide binding]; other site
425104010856	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
425104010857	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
425104010858	nucleotide binding site [chemical binding]; other site
425104010859	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
425104010860	EamA-like transporter family; Region: EamA; pfam00892
425104010861	EamA-like transporter family; Region: EamA; cl17759
425104010862	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
425104010863	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
425104010864	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104010865	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
425104010866	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
425104010867	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
425104010868	putative catalytic cysteine [active]
425104010869	gamma-glutamyl kinase; Provisional; Region: PRK05429
425104010870	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
425104010871	nucleotide binding site [chemical binding]; other site
425104010872	homotetrameric interface [polypeptide binding]; other site
425104010873	putative phosphate binding site [ion binding]; other site
425104010874	putative allosteric binding site; other site
425104010875	PUA domain; Region: PUA; pfam01472
425104010876	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
425104010877	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
425104010878	interface (dimer of trimers) [polypeptide binding]; other site
425104010879	Substrate-binding/catalytic site; other site
425104010880	Zn-binding sites [ion binding]; other site
425104010881	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
425104010882	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
425104010883	metal binding site [ion binding]; metal-binding site
425104010884	dimer interface [polypeptide binding]; other site
425104010885	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
425104010886	active site
425104010887	DNA polymerase IV; Validated; Region: PRK02406
425104010888	DNA binding site [nucleotide binding]
425104010889	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104010890	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104010891	metal binding site [ion binding]; metal-binding site
425104010892	active site
425104010893	I-site; other site
425104010894	Protein of unknown function (DUF539); Region: DUF539; cl01129
425104010895	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
425104010896	ApbE family; Region: ApbE; pfam02424
425104010897	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
425104010898	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
425104010899	catalytic loop [active]
425104010900	iron binding site [ion binding]; other site
425104010901	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
425104010902	FAD binding pocket [chemical binding]; other site
425104010903	FAD binding motif [chemical binding]; other site
425104010904	phosphate binding motif [ion binding]; other site
425104010905	beta-alpha-beta structure motif; other site
425104010906	NAD binding pocket [chemical binding]; other site
425104010907	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
425104010908	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
425104010909	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
425104010910	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
425104010911	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
425104010912	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
425104010913	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
425104010914	S-ribosylhomocysteinase; Provisional; Region: PRK02260
425104010915	BolA-like protein; Region: BolA; cl00386
425104010916	ACT domain; Region: ACT_6; pfam13740
425104010917	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
425104010918	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
425104010919	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
425104010920	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104010921	S-adenosylmethionine binding site [chemical binding]; other site
425104010922	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
425104010923	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
425104010924	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056
425104010925	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
425104010926	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
425104010927	active site
425104010928	muropeptide transporter; Reviewed; Region: ampG; PRK11902
425104010929	AmpG-like permease; Region: 2A0125; TIGR00901
425104010930	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
425104010931	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
425104010932	Predicted integral membrane protein [Function unknown]; Region: COG5652
425104010933	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
425104010934	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
425104010935	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
425104010936	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
425104010937	Na2 binding site [ion binding]; other site
425104010938	putative substrate binding site 1 [chemical binding]; other site
425104010939	Na binding site 1 [ion binding]; other site
425104010940	putative substrate binding site 2 [chemical binding]; other site
425104010941	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
425104010942	active site
425104010943	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
425104010944	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
425104010945	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
425104010946	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
425104010947	Protein of unknown function (DUF819); Region: DUF819; cl02317
425104010948	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
425104010949	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
425104010950	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104010951	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104010952	The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468
425104010953	putative substrate binding pocket [chemical binding]; other site
425104010954	dimerization interface [polypeptide binding]; other site
425104010955	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104010956	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
425104010957	Coenzyme A binding pocket [chemical binding]; other site
425104010958	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
425104010959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104010960	S-adenosylmethionine binding site [chemical binding]; other site
425104010961	peptide chain release factor 1; Validated; Region: prfA; PRK00591
425104010962	This domain is found in peptide chain release factors; Region: PCRF; smart00937
425104010963	RF-1 domain; Region: RF-1; pfam00472
425104010964	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
425104010965	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
425104010966	tRNA; other site
425104010967	putative tRNA binding site [nucleotide binding]; other site
425104010968	putative NADP binding site [chemical binding]; other site
425104010969	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
425104010970	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
425104010971	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
425104010972	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
425104010973	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
425104010974	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
425104010975	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
425104010976	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
425104010977	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
425104010978	active site
425104010979	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
425104010980	catalytic residues [active]
425104010981	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
425104010982	DNA binding site [nucleotide binding]
425104010983	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
425104010984	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
425104010985	heme-binding residues [chemical binding]; other site
425104010986	GTP-binding protein YchF; Reviewed; Region: PRK09601
425104010987	YchF GTPase; Region: YchF; cd01900
425104010988	G1 box; other site
425104010989	GTP/Mg2+ binding site [chemical binding]; other site
425104010990	Switch I region; other site
425104010991	G2 box; other site
425104010992	Switch II region; other site
425104010993	G3 box; other site
425104010994	G4 box; other site
425104010995	G5 box; other site
425104010996	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
425104010997	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
425104010998	putative active site [active]
425104010999	catalytic residue [active]
425104011000	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
425104011001	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849
425104011002	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
425104011003	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
425104011004	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104011005	FeS/SAM binding site; other site
425104011006	TRAM domain; Region: TRAM; pfam01938
425104011007	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
425104011008	PhoH-like protein; Region: PhoH; pfam02562
425104011009	metal-binding heat shock protein; Provisional; Region: PRK00016
425104011010	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
425104011011	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
425104011012	Transporter associated domain; Region: CorC_HlyC; smart01091
425104011013	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
425104011014	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
425104011015	putative active site [active]
425104011016	catalytic triad [active]
425104011017	putative dimer interface [polypeptide binding]; other site
425104011018	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104011019	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104011020	metal binding site [ion binding]; metal-binding site
425104011021	active site
425104011022	I-site; other site
425104011023	Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581
425104011024	Cache domain; Region: Cache_1; pfam02743
425104011025	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104011026	dimerization interface [polypeptide binding]; other site
425104011027	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104011028	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104011029	dimer interface [polypeptide binding]; other site
425104011030	putative CheW interface [polypeptide binding]; other site
425104011031	Protein of unknown function (DUF1451); Region: DUF1451; pfam07295
425104011032	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
425104011033	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
425104011034	HIGH motif; other site
425104011035	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
425104011036	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
425104011037	active site
425104011038	KMSKS motif; other site
425104011039	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
425104011040	tRNA binding surface [nucleotide binding]; other site
425104011041	Lipopolysaccharide-assembly; Region: LptE; cl01125
425104011042	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
425104011043	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
425104011044	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
425104011045	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
425104011046	active site
425104011047	(T/H)XGH motif; other site
425104011048	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
425104011049	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
425104011050	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
425104011051	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
425104011052	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
425104011053	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
425104011054	Transglycosylase SLT domain; Region: SLT_2; pfam13406
425104011055	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
425104011056	N-acetyl-D-glucosamine binding site [chemical binding]; other site
425104011057	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
425104011058	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
425104011059	Sporulation related domain; Region: SPOR; pfam05036
425104011060	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
425104011061	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
425104011062	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
425104011063	hypothetical protein; Provisional; Region: PRK04998
425104011064	lipoate-protein ligase B; Provisional; Region: PRK14342
425104011065	lipoyl synthase; Provisional; Region: PRK05481
425104011066	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104011067	FeS/SAM binding site; other site
425104011068	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
425104011069	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
425104011070	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
425104011071	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
425104011072	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
425104011073	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
425104011074	Clp amino terminal domain; Region: Clp_N; pfam02861
425104011075	Clp amino terminal domain; Region: Clp_N; pfam02861
425104011076	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104011077	Walker A motif; other site
425104011078	ATP binding site [chemical binding]; other site
425104011079	Walker B motif; other site
425104011080	arginine finger; other site
425104011081	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104011082	Walker A motif; other site
425104011083	ATP binding site [chemical binding]; other site
425104011084	Walker B motif; other site
425104011085	arginine finger; other site
425104011086	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
425104011087	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
425104011088	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
425104011089	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
425104011090	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
425104011091	RNA binding surface [nucleotide binding]; other site
425104011092	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
425104011093	active site
425104011094	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
425104011095	CHASE4 domain; Region: CHASE4; pfam05228
425104011096	HAMP domain; Region: HAMP; pfam00672
425104011097	dimerization interface [polypeptide binding]; other site
425104011098	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104011099	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104011100	metal binding site [ion binding]; metal-binding site
425104011101	active site
425104011102	I-site; other site
425104011103	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104011104	dimerization interface [polypeptide binding]; other site
425104011105	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104011106	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104011107	dimer interface [polypeptide binding]; other site
425104011108	putative CheW interface [polypeptide binding]; other site
425104011109	ornithine cyclodeaminase; Validated; Region: PRK06141
425104011110	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
425104011111	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
425104011112	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
425104011113	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
425104011114	DNA binding residues [nucleotide binding]
425104011115	Uncharacterized conserved protein [Function unknown]; Region: COG3595
425104011116	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
425104011117	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
425104011118	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
425104011119	RNA binding surface [nucleotide binding]; other site
425104011120	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
425104011121	active site
425104011122	uracil binding [chemical binding]; other site
425104011123	maltose O-acetyltransferase; Provisional; Region: PRK10092
425104011124	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
425104011125	active site
425104011126	substrate binding site [chemical binding]; other site
425104011127	trimer interface [polypeptide binding]; other site
425104011128	CoA binding site [chemical binding]; other site
425104011129	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
425104011130	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
425104011131	active site
425104011132	Zn binding site [ion binding]; other site
425104011133	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
425104011134	synthetase active site [active]
425104011135	metal binding site [ion binding]; metal-binding site
425104011136	NTP binding site [chemical binding]; other site
425104011137	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
425104011138	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
425104011139	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
425104011140	putative C-terminal domain interface [polypeptide binding]; other site
425104011141	putative GSH binding site (G-site) [chemical binding]; other site
425104011142	putative dimer interface [polypeptide binding]; other site
425104011143	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
425104011144	dimer interface [polypeptide binding]; other site
425104011145	N-terminal domain interface [polypeptide binding]; other site
425104011146	putative substrate binding pocket (H-site) [chemical binding]; other site
425104011147	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
425104011148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104011149	active site
425104011150	phosphorylation site [posttranslational modification]
425104011151	intermolecular recognition site; other site
425104011152	dimerization interface [polypeptide binding]; other site
425104011153	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
425104011154	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
425104011155	Beta-lactamase; Region: Beta-lactamase; pfam00144
425104011156	Beta-lactamase; Region: Beta-lactamase; pfam00144
425104011157	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
425104011158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
425104011159	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
425104011160	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
425104011161	malate dehydrogenase; Provisional; Region: PRK13529
425104011162	Malic enzyme, N-terminal domain; Region: malic; pfam00390
425104011163	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
425104011164	NAD(P) binding site [chemical binding]; other site
425104011165	Protein of unknown function (DUF3069); Region: DUF3069; pfam11269
425104011166	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
425104011167	active site
425104011168	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
425104011169	Tetratricopeptide repeat; Region: TPR_12; pfam13424
425104011170	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104011171	binding surface
425104011172	Tetratricopeptide repeat; Region: TPR_12; pfam13424
425104011173	TPR motif; other site
425104011174	Tetratricopeptide repeat; Region: TPR_12; pfam13424
425104011175	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104011176	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104011177	metal binding site [ion binding]; metal-binding site
425104011178	active site
425104011179	I-site; other site
425104011180	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
425104011181	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104011182	substrate binding pocket [chemical binding]; other site
425104011183	membrane-bound complex binding site; other site
425104011184	hinge residues; other site
425104011185	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
425104011186	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
425104011187	active site
425104011188	purine riboside binding site [chemical binding]; other site
425104011189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104011190	Major Facilitator Superfamily; Region: MFS_1; pfam07690
425104011191	putative substrate translocation pore; other site
425104011192	epoxyqueuosine reductase; Region: TIGR00276
425104011193	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
425104011194	Dodecin; Region: Dodecin; pfam07311
425104011195	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
425104011196	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
425104011197	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
425104011198	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104011199	Pleckstrin homology-like domain; Region: PH-like; cl17171
425104011200	Lipase (class 2); Region: Lipase_2; pfam01674
425104011201	Cache domain; Region: Cache_2; pfam08269
425104011202	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104011203	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104011204	dimerization interface [polypeptide binding]; other site
425104011205	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104011206	dimer interface [polypeptide binding]; other site
425104011207	putative CheW interface [polypeptide binding]; other site
425104011208	putative acyltransferase; Provisional; Region: PRK05790
425104011209	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
425104011210	dimer interface [polypeptide binding]; other site
425104011211	active site
425104011212	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
425104011213	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
425104011214	NAD(P) binding site [chemical binding]; other site
425104011215	homotetramer interface [polypeptide binding]; other site
425104011216	homodimer interface [polypeptide binding]; other site
425104011217	active site
425104011218	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104011219	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011220	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104011221	putative effector binding pocket; other site
425104011222	dimerization interface [polypeptide binding]; other site
425104011223	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
425104011224	Coenzyme A transferase; Region: CoA_trans; smart00882
425104011225	Coenzyme A transferase; Region: CoA_trans; cl17247
425104011226	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
425104011227	dimer interaction site [polypeptide binding]; other site
425104011228	substrate-binding tunnel; other site
425104011229	active site
425104011230	catalytic site [active]
425104011231	substrate binding site [chemical binding]; other site
425104011232	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
425104011233	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
425104011234	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
425104011235	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
425104011236	propionate/acetate kinase; Provisional; Region: PRK12379
425104011237	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
425104011238	phosphate acetyltransferase; Reviewed; Region: PRK05632
425104011239	DRTGG domain; Region: DRTGG; pfam07085
425104011240	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
425104011241	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
425104011242	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
425104011243	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
425104011244	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
425104011245	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
425104011246	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
425104011247	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
425104011248	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
425104011249	catalytic residues [active]
425104011250	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
425104011251	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
425104011252	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
425104011253	homotrimer interaction site [polypeptide binding]; other site
425104011254	putative active site [active]
425104011255	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
425104011256	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
425104011257	catalytic residues [active]
425104011258	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
425104011259	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
425104011260	catalytic residues [active]
425104011261	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
425104011262	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
425104011263	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
425104011264	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
425104011265	DsbD alpha interface [polypeptide binding]; other site
425104011266	catalytic residues [active]
425104011267	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
425104011268	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
425104011269	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
425104011270	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
425104011271	active site
425104011272	FMN binding site [chemical binding]; other site
425104011273	substrate binding site [chemical binding]; other site
425104011274	3Fe-4S cluster binding site [ion binding]; other site
425104011275	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
425104011276	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
425104011277	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
425104011278	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
425104011279	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
425104011280	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
425104011281	THF binding site; other site
425104011282	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
425104011283	substrate binding site [chemical binding]; other site
425104011284	THF binding site; other site
425104011285	zinc-binding site [ion binding]; other site
425104011286	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104011287	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011288	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
425104011289	putative dimerization interface [polypeptide binding]; other site
425104011290	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
425104011291	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
425104011292	active site
425104011293	catalytic triad [active]
425104011294	oxyanion hole [active]
425104011295	switch loop; other site
425104011296	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
425104011297	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104011298	N-terminal plug; other site
425104011299	ligand-binding site [chemical binding]; other site
425104011300	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
425104011301	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
425104011302	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
425104011303	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
425104011304	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
425104011305	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104011306	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011307	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104011308	dimerization interface [polypeptide binding]; other site
425104011309	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104011310	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011311	LysR substrate binding domain; Region: LysR_substrate; pfam03466
425104011312	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
425104011313	inhibitor binding site; inhibition site
425104011314	catalytic motif [active]
425104011315	Catalytic residue [active]
425104011316	Active site flap [active]
425104011317	Pepsin-like aspartic proteases, bilobal enzymes that cleave bonds in peptides at acidic pH; Region: pepsin_like; cd05471
425104011318	inhibitor binding site; inhibition site
425104011319	catalytic motif [active]
425104011320	catalytic residue [active]
425104011321	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
425104011322	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
425104011323	active site
425104011324	SAM binding site [chemical binding]; other site
425104011325	homodimer interface [polypeptide binding]; other site
425104011326	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104011327	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104011328	metal binding site [ion binding]; metal-binding site
425104011329	active site
425104011330	I-site; other site
425104011331	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
425104011332	Clp amino terminal domain; Region: Clp_N; pfam02861
425104011333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104011334	Walker A motif; other site
425104011335	ATP binding site [chemical binding]; other site
425104011336	Walker B motif; other site
425104011337	arginine finger; other site
425104011338	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104011339	Walker A motif; other site
425104011340	ATP binding site [chemical binding]; other site
425104011341	Walker B motif; other site
425104011342	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
425104011343	Predicted flavoprotein [General function prediction only]; Region: COG0431
425104011344	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
425104011345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104011346	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
425104011347	putative substrate translocation pore; other site
425104011348	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104011349	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011350	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104011351	putative effector binding pocket; other site
425104011352	dimerization interface [polypeptide binding]; other site
425104011353	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
425104011354	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
425104011355	catalytic loop [active]
425104011356	iron binding site [ion binding]; other site
425104011357	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
425104011358	FAD binding pocket [chemical binding]; other site
425104011359	FAD binding motif [chemical binding]; other site
425104011360	phosphate binding motif [ion binding]; other site
425104011361	beta-alpha-beta structure motif; other site
425104011362	NAD binding pocket [chemical binding]; other site
425104011363	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
425104011364	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
425104011365	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
425104011366	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
425104011367	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
425104011368	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
425104011369	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
425104011370	E3 interaction surface; other site
425104011371	lipoyl attachment site [posttranslational modification]; other site
425104011372	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
425104011373	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
425104011374	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
425104011375	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
425104011376	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104011377	substrate binding pocket [chemical binding]; other site
425104011378	membrane-bound complex binding site; other site
425104011379	hinge residues; other site
425104011380	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
425104011381	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
425104011382	TM-ABC transporter signature motif; other site
425104011383	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
425104011384	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
425104011385	TM-ABC transporter signature motif; other site
425104011386	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
425104011387	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
425104011388	Walker A/P-loop; other site
425104011389	ATP binding site [chemical binding]; other site
425104011390	Q-loop/lid; other site
425104011391	ABC transporter signature motif; other site
425104011392	Walker B; other site
425104011393	D-loop; other site
425104011394	H-loop/switch region; other site
425104011395	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
425104011396	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
425104011397	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
425104011398	ligand binding site [chemical binding]; other site
425104011399	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
425104011400	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104011401	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011402	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104011403	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011404	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104011405	dimerization interface [polypeptide binding]; other site
425104011406	chaperone protein DnaJ; Provisional; Region: PRK14289
425104011407	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
425104011408	putative catalytic residues [active]
425104011409	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104011410	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104011411	membrane-bound complex binding site; other site
425104011412	hinge residues; other site
425104011413	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
425104011414	active site
425104011415	substrate binding pocket [chemical binding]; other site
425104011416	dimer interface [polypeptide binding]; other site
425104011417	Predicted permease; Region: DUF318; cl17795
425104011418	Predicted permease; Region: DUF318; cl17795
425104011419	Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily; Region: eu-GS; cl00170
425104011420	dimerization unit; other site
425104011421	glutathione (GSH) binding pocket [chemical binding]; other site
425104011422	active site residues [active]
425104011423	ATP binding pocket [chemical binding]; other site
425104011424	magnesium binding site [ion binding]; other site
425104011425	glycine rich loop; other site
425104011426	alanine rich loop; other site
425104011427	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
425104011428	dimerization interface [polypeptide binding]; other site
425104011429	putative DNA binding site [nucleotide binding]; other site
425104011430	putative Zn2+ binding site [ion binding]; other site
425104011431	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
425104011432	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
425104011433	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
425104011434	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
425104011435	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104011436	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
425104011437	active site
425104011438	metal binding site [ion binding]; metal-binding site
425104011439	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104011440	NmrA-like family; Region: NmrA; pfam05368
425104011441	NAD(P) binding site [chemical binding]; other site
425104011442	active site
425104011443	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
425104011444	Helix-turn-helix domain; Region: HTH_18; pfam12833
425104011445	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
425104011446	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
425104011447	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
425104011448	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
425104011449	Uncharacterized conserved protein [Function unknown]; Region: COG1359
425104011450	transcriptional regulator; Provisional; Region: PRK10632
425104011451	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011452	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
425104011453	putative effector binding pocket; other site
425104011454	putative dimerization interface [polypeptide binding]; other site
425104011455	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
425104011456	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
425104011457	purine nucleoside phosphorylase; Provisional; Region: PRK13374
425104011458	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
425104011459	putative NAD(P) binding site [chemical binding]; other site
425104011460	homodimer interface [polypeptide binding]; other site
425104011461	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104011462	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011463	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104011464	putative effector binding pocket; other site
425104011465	dimerization interface [polypeptide binding]; other site
425104011466	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104011467	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011468	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104011469	putative effector binding pocket; other site
425104011470	dimerization interface [polypeptide binding]; other site
425104011471	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
425104011472	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
425104011473	substrate binding site [chemical binding]; other site
425104011474	oxyanion hole (OAH) forming residues; other site
425104011475	trimer interface [polypeptide binding]; other site
425104011476	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
425104011477	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104011478	FeS/SAM binding site; other site
425104011479	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
425104011480	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
425104011481	Predicted flavoprotein [General function prediction only]; Region: COG0431
425104011482	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
425104011483	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
425104011484	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104011485	CHASE2 domain; Region: CHASE2; pfam05226
425104011486	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
425104011487	cyclase homology domain; Region: CHD; cd07302
425104011488	nucleotidyl binding site; other site
425104011489	metal binding site [ion binding]; metal-binding site
425104011490	dimer interface [polypeptide binding]; other site
425104011491	Peptidase family M48; Region: Peptidase_M48; pfam01435
425104011492	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104011493	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104011494	metal binding site [ion binding]; metal-binding site
425104011495	active site
425104011496	I-site; other site
425104011497	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
425104011498	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104011499	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
425104011500	Protein of unknown function (DUF465); Region: DUF465; pfam04325
425104011501	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
425104011502	SPFH domain / Band 7 family; Region: Band_7; pfam01145
425104011503	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
425104011504	Leucine rich repeat; Region: LRR_8; pfam13855
425104011505	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
425104011506	Substrate binding site [chemical binding]; other site
425104011507	Leucine rich repeat; Region: LRR_8; pfam13855
425104011508	Domain of unknown function (DUF3859); Region: DUF3859; pfam12975
425104011509	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
425104011510	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
425104011511	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
425104011512	active site
425104011513	Zn binding site [ion binding]; other site
425104011514	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
425104011515	The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759
425104011516	putative [Fe4-S4] binding site [ion binding]; other site
425104011517	putative molybdopterin cofactor binding site [chemical binding]; other site
425104011518	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
425104011519	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
425104011520	molybdopterin cofactor binding site; other site
425104011521	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
425104011522	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
425104011523	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104011524	N-terminal plug; other site
425104011525	ligand-binding site [chemical binding]; other site
425104011526	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
425104011527	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
425104011528	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
425104011529	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
425104011530	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
425104011531	active site
425104011532	metal binding site [ion binding]; metal-binding site
425104011533	AAA domain; Region: AAA_28; pfam13521
425104011534	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104011535	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104011536	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
425104011537	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
425104011538	FMN binding site [chemical binding]; other site
425104011539	active site
425104011540	substrate binding site [chemical binding]; other site
425104011541	catalytic residue [active]
425104011542	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
425104011543	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
425104011544	inhibitor-cofactor binding pocket; inhibition site
425104011545	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104011546	catalytic residue [active]
425104011547	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
425104011548	TAP-like protein; Region: Abhydrolase_4; pfam08386
425104011549	Predicted periplasmic protein [Function unknown]; Region: COG3904
425104011550	Ribosome recycling factor; Region: RRF_GI; pfam12614
425104011551	HDOD domain; Region: HDOD; pfam08668
425104011552	Protein of unknown function (DUF3360); Region: DUF3360; pfam11840
425104011553	Protein of unknown function (DUF3083); Region: DUF3083; pfam11281
425104011554	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
425104011555	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
425104011556	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
425104011557	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
425104011558	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
425104011559	peptidase T-like protein; Region: PepT-like; TIGR01883
425104011560	metal binding site [ion binding]; metal-binding site
425104011561	putative dimer interface [polypeptide binding]; other site
425104011562	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
425104011563	catalytic motif [active]
425104011564	Zn binding site [ion binding]; other site
425104011565	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
425104011566	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
425104011567	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
425104011568	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
425104011569	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12507
425104011570	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
425104011571	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
425104011572	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
425104011573	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
425104011574	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
425104011575	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
425104011576	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
425104011577	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668
425104011578	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
425104011579	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
425104011580	HAMP domain; Region: HAMP; pfam00672
425104011581	dimerization interface [polypeptide binding]; other site
425104011582	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104011583	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104011584	metal binding site [ion binding]; metal-binding site
425104011585	active site
425104011586	I-site; other site
425104011587	glycine dehydrogenase; Provisional; Region: PRK05367
425104011588	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
425104011589	tetramer interface [polypeptide binding]; other site
425104011590	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104011591	catalytic residue [active]
425104011592	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
425104011593	tetramer interface [polypeptide binding]; other site
425104011594	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104011595	catalytic residue [active]
425104011596	glycine cleavage system protein H; Provisional; Region: PRK13380
425104011597	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
425104011598	lipoyl attachment site [posttranslational modification]; other site
425104011599	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
425104011600	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
425104011601	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
425104011602	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
425104011603	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
425104011604	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
425104011605	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
425104011606	Cell division protein ZapA; Region: ZapA; cl01146
425104011607	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
425104011608	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
425104011609	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
425104011610	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
425104011611	ligand binding site [chemical binding]; other site
425104011612	flexible hinge region; other site
425104011613	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
425104011614	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
425104011615	ligand binding site [chemical binding]; other site
425104011616	flexible hinge region; other site
425104011617	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
425104011618	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
425104011619	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
425104011620	NlpE N-terminal domain; Region: NlpE; pfam04170
425104011621	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
425104011622	ligand binding site [chemical binding]; other site
425104011623	active site
425104011624	UGI interface [polypeptide binding]; other site
425104011625	catalytic site [active]
425104011626	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
425104011627	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
425104011628	PAS domain S-box; Region: sensory_box; TIGR00229
425104011629	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104011630	putative active site [active]
425104011631	heme pocket [chemical binding]; other site
425104011632	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104011633	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
425104011634	Walker A motif; other site
425104011635	ATP binding site [chemical binding]; other site
425104011636	Walker B motif; other site
425104011637	arginine finger; other site
425104011638	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104011639	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
425104011640	4Fe-4S binding domain; Region: Fer4_5; pfam12801
425104011641	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
425104011642	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
425104011643	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
425104011644	acyl-activating enzyme (AAE) consensus motif; other site
425104011645	putative AMP binding site [chemical binding]; other site
425104011646	putative active site [active]
425104011647	putative CoA binding site [chemical binding]; other site
425104011648	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
425104011649	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
425104011650	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
425104011651	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
425104011652	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104011653	Walker A/P-loop; other site
425104011654	ATP binding site [chemical binding]; other site
425104011655	Q-loop/lid; other site
425104011656	ABC transporter signature motif; other site
425104011657	Walker B; other site
425104011658	D-loop; other site
425104011659	H-loop/switch region; other site
425104011660	Protein of unknown function (DUF2956); Region: DUF2956; pfam11169
425104011661	Ion transport protein; Region: Ion_trans; pfam00520
425104011662	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904
425104011663	Bacterial PH domain; Region: DUF304; cl01348
425104011664	Predicted membrane protein [Function unknown]; Region: COG3428
425104011665	Bacterial PH domain; Region: DUF304; pfam03703
425104011666	Bacterial PH domain; Region: DUF304; pfam03703
425104011667	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
425104011668	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
425104011669	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104011670	HAMP domain; Region: HAMP; pfam00672
425104011671	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104011672	dimer interface [polypeptide binding]; other site
425104011673	putative CheW interface [polypeptide binding]; other site
425104011674	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104011675	Ligand Binding Site [chemical binding]; other site
425104011676	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
425104011677	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
425104011678	dimer interface [polypeptide binding]; other site
425104011679	active site
425104011680	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
425104011681	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
425104011682	inhibitor-cofactor binding pocket; inhibition site
425104011683	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104011684	catalytic residue [active]
425104011685	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
425104011686	Coenzyme A transferase; Region: CoA_trans; cl17247
425104011687	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
425104011688	FeS/SAM binding site; other site
425104011689	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104011690	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011691	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104011692	dimerization interface [polypeptide binding]; other site
425104011693	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104011694	Ligand Binding Site [chemical binding]; other site
425104011695	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104011696	Ligand Binding Site [chemical binding]; other site
425104011697	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
425104011698	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
425104011699	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
425104011700	NAD(P) binding site [chemical binding]; other site
425104011701	catalytic residues [active]
425104011702	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104011703	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104011704	HAMP domain; Region: HAMP; pfam00672
425104011705	PAS domain; Region: PAS_8; pfam13188
425104011706	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
425104011707	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104011708	ATP binding site [chemical binding]; other site
425104011709	Mg2+ binding site [ion binding]; other site
425104011710	G-X-G motif; other site
425104011711	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
425104011712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104011713	active site
425104011714	phosphorylation site [posttranslational modification]
425104011715	intermolecular recognition site; other site
425104011716	dimerization interface [polypeptide binding]; other site
425104011717	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104011718	Walker A motif; other site
425104011719	ATP binding site [chemical binding]; other site
425104011720	Walker B motif; other site
425104011721	arginine finger; other site
425104011722	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104011723	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
425104011724	FtsX-like permease family; Region: FtsX; pfam02687
425104011725	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
425104011726	FtsX-like permease family; Region: FtsX; pfam02687
425104011727	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
425104011728	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
425104011729	Walker A/P-loop; other site
425104011730	ATP binding site [chemical binding]; other site
425104011731	Q-loop/lid; other site
425104011732	ABC transporter signature motif; other site
425104011733	Walker B; other site
425104011734	D-loop; other site
425104011735	H-loop/switch region; other site
425104011736	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104011737	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
425104011738	lipoyl-biotinyl attachment site [posttranslational modification]; other site
425104011739	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104011740	Predicted transporter component [General function prediction only]; Region: COG2391
425104011741	Sulphur transport; Region: Sulf_transp; pfam04143
425104011742	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
425104011743	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
425104011744	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
425104011745	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
425104011746	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
425104011747	active site residue [active]
425104011748	MAPEG family; Region: MAPEG; cl09190
425104011749	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
425104011750	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
425104011751	cobalamin binding residues [chemical binding]; other site
425104011752	putative BtuC binding residues; other site
425104011753	dimer interface [polypeptide binding]; other site
425104011754	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
425104011755	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
425104011756	cobyric acid synthase; Provisional; Region: PRK00784
425104011757	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
425104011758	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
425104011759	catalytic triad [active]
425104011760	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
425104011761	homotrimer interface [polypeptide binding]; other site
425104011762	Walker A motif; other site
425104011763	GTP binding site [chemical binding]; other site
425104011764	Walker B motif; other site
425104011765	cobalamin synthase; Reviewed; Region: cobS; PRK00235
425104011766	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
425104011767	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
425104011768	putative dimer interface [polypeptide binding]; other site
425104011769	active site pocket [active]
425104011770	putative cataytic base [active]
425104011771	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
425104011772	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
425104011773	ABC-ATPase subunit  interface; other site
425104011774	dimer interface [polypeptide binding]; other site
425104011775	putative PBP binding regions; other site
425104011776	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
425104011777	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
425104011778	Walker A/P-loop; other site
425104011779	ATP binding site [chemical binding]; other site
425104011780	Q-loop/lid; other site
425104011781	ABC transporter signature motif; other site
425104011782	Walker B; other site
425104011783	D-loop; other site
425104011784	H-loop/switch region; other site
425104011785	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
425104011786	catalytic core [active]
425104011787	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
425104011788	Na binding site [ion binding]; other site
425104011789	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104011790	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104011791	ATP binding site [chemical binding]; other site
425104011792	Mg2+ binding site [ion binding]; other site
425104011793	G-X-G motif; other site
425104011794	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
425104011795	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
425104011796	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
425104011797	substrate binding pocket [chemical binding]; other site
425104011798	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
425104011799	B12 binding site [chemical binding]; other site
425104011800	cobalt ligand [ion binding]; other site
425104011801	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
425104011802	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
425104011803	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104011804	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011805	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104011806	dimerization interface [polypeptide binding]; other site
425104011807	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
425104011808	Predicted membrane protein [Function unknown]; Region: COG4125
425104011809	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
425104011810	Cytochrome c552; Region: Cytochrom_C552; pfam02335
425104011811	Protein of unknown function (DUF465); Region: DUF465; pfam04325
425104011812	PII uridylyl-transferase; Provisional; Region: PRK05007
425104011813	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
425104011814	metal binding triad; other site
425104011815	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
425104011816	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104011817	Zn2+ binding site [ion binding]; other site
425104011818	Mg2+ binding site [ion binding]; other site
425104011819	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
425104011820	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
425104011821	TIR domain; Region: TIR_2; pfam13676
425104011822	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
425104011823	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
425104011824	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
425104011825	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
425104011826	TM2 domain; Region: TM2; pfam05154
425104011827	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
425104011828	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
425104011829	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
425104011830	putative N-terminal domain interface [polypeptide binding]; other site
425104011831	putative dimer interface [polypeptide binding]; other site
425104011832	putative substrate binding pocket (H-site) [chemical binding]; other site
425104011833	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
425104011834	Peptidase family U32; Region: Peptidase_U32; pfam01136
425104011835	Collagenase; Region: DUF3656; pfam12392
425104011836	Peptidase family U32; Region: Peptidase_U32; cl03113
425104011837	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
425104011838	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
425104011839	active site
425104011840	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
425104011841	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
425104011842	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
425104011843	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104011844	dimerization interface [polypeptide binding]; other site
425104011845	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104011846	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104011847	dimer interface [polypeptide binding]; other site
425104011848	putative CheW interface [polypeptide binding]; other site
425104011849	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104011850	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104011851	substrate binding pocket [chemical binding]; other site
425104011852	membrane-bound complex binding site; other site
425104011853	hinge residues; other site
425104011854	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104011855	dimer interface [polypeptide binding]; other site
425104011856	conserved gate region; other site
425104011857	putative PBP binding loops; other site
425104011858	ABC-ATPase subunit interface; other site
425104011859	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
425104011860	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
425104011861	Walker A/P-loop; other site
425104011862	ATP binding site [chemical binding]; other site
425104011863	Q-loop/lid; other site
425104011864	ABC transporter signature motif; other site
425104011865	Walker B; other site
425104011866	D-loop; other site
425104011867	H-loop/switch region; other site
425104011868	synthase/transferase; Region: PLN02316
425104011869	Response regulator receiver domain; Region: Response_reg; pfam00072
425104011870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104011871	active site
425104011872	phosphorylation site [posttranslational modification]
425104011873	intermolecular recognition site; other site
425104011874	dimerization interface [polypeptide binding]; other site
425104011875	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
425104011876	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
425104011877	FMN-binding domain; Region: FMN_bind; pfam04205
425104011878	4Fe-4S binding domain; Region: Fer4_5; pfam12801
425104011879	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
425104011880	Flavodoxin; Region: Flavodoxin_1; pfam00258
425104011881	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
425104011882	FAD binding pocket [chemical binding]; other site
425104011883	FAD binding motif [chemical binding]; other site
425104011884	catalytic residues [active]
425104011885	NAD binding pocket [chemical binding]; other site
425104011886	phosphate binding motif [ion binding]; other site
425104011887	beta-alpha-beta structure motif; other site
425104011888	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
425104011889	reductive dehalogenase; Region: RDH; TIGR02486
425104011890	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104011891	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104011892	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104011893	dimerization interface [polypeptide binding]; other site
425104011894	Pirin-related protein [General function prediction only]; Region: COG1741
425104011895	Pirin; Region: Pirin; pfam02678
425104011896	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
425104011897	hypothetical protein; Validated; Region: PRK00029
425104011898	Uncharacterized conserved protein [Function unknown]; Region: COG0397
425104011899	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
425104011900	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
425104011901	active site residue [active]
425104011902	Domain of unknown function; Region: DUF331; pfam03889
425104011903	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
425104011904	EamA-like transporter family; Region: EamA; pfam00892
425104011905	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104011906	dimerization interface [polypeptide binding]; other site
425104011907	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104011908	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104011909	metal binding site [ion binding]; metal-binding site
425104011910	active site
425104011911	I-site; other site
425104011912	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
425104011913	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104011914	substrate binding pocket [chemical binding]; other site
425104011915	membrane-bound complex binding site; other site
425104011916	Cache domain; Region: Cache_1; pfam02743
425104011917	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104011918	Zn2+ binding site [ion binding]; other site
425104011919	Mg2+ binding site [ion binding]; other site
425104011920	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
425104011921	putative catalytic site [active]
425104011922	putative metal binding site [ion binding]; other site
425104011923	putative phosphate binding site [ion binding]; other site
425104011924	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
425104011925	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
425104011926	CHASE domain; Region: CHASE; pfam03924
425104011927	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104011928	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104011929	metal binding site [ion binding]; metal-binding site
425104011930	active site
425104011931	I-site; other site
425104011932	CHASE domain; Region: CHASE; pfam03924
425104011933	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104011934	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104011935	metal binding site [ion binding]; metal-binding site
425104011936	active site
425104011937	I-site; other site
425104011938	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
425104011939	FMN binding site [chemical binding]; other site
425104011940	dimer interface [polypeptide binding]; other site
425104011941	DNA-J related protein; Region: DNAJ_related; pfam12339
425104011942	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
425104011943	HSP70 interaction site [polypeptide binding]; other site
425104011944	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
425104011945	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
425104011946	catalytic residues [active]
425104011947	hinge region; other site
425104011948	alpha helical domain; other site
425104011949	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
425104011950	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
425104011951	Flavodoxin domain; Region: Flavodoxin_5; cl17428
425104011952	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
425104011953	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
425104011954	Imelysin; Region: Peptidase_M75; pfam09375
425104011955	Uncharacterized conserved protein [Function unknown]; Region: COG1262
425104011956	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
425104011957	Major Facilitator Superfamily; Region: MFS_1; pfam07690
425104011958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104011959	putative substrate translocation pore; other site
425104011960	TIGR03899 family protein; Region: TIGR03899
425104011961	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
425104011962	active site
425104011963	SAM binding site [chemical binding]; other site
425104011964	homodimer interface [polypeptide binding]; other site
425104011965	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
425104011966	Active site serine [active]
425104011967	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
425104011968	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
425104011969	catalytic triad [active]
425104011970	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
425104011971	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
425104011972	ATP binding site [chemical binding]; other site
425104011973	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
425104011974	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
425104011975	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
425104011976	Active Sites [active]
425104011977	sulfite reductase subunit beta; Provisional; Region: PRK13504
425104011978	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
425104011979	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
425104011980	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
425104011981	Flavodoxin; Region: Flavodoxin_1; pfam00258
425104011982	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
425104011983	FAD binding pocket [chemical binding]; other site
425104011984	FAD binding motif [chemical binding]; other site
425104011985	catalytic residues [active]
425104011986	NAD binding pocket [chemical binding]; other site
425104011987	phosphate binding motif [ion binding]; other site
425104011988	beta-alpha-beta structure motif; other site
425104011989	MltA-interacting protein MipA; Region: MipA; cl01504
425104011990	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
425104011991	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
425104011992	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
425104011993	putative ribose interaction site [chemical binding]; other site
425104011994	putative ADP binding site [chemical binding]; other site
425104011995	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
425104011996	active site
425104011997	nucleotide binding site [chemical binding]; other site
425104011998	HIGH motif; other site
425104011999	KMSKS motif; other site
425104012000	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
425104012001	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
425104012002	putative acyl-acceptor binding pocket; other site
425104012003	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
425104012004	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
425104012005	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
425104012006	ApbE family; Region: ApbE; pfam02424
425104012007	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
425104012008	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
425104012009	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
425104012010	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
425104012011	catalytic residues [active]
425104012012	potassium/proton antiporter; Reviewed; Region: PRK05326
425104012013	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
425104012014	TrkA-C domain; Region: TrkA_C; pfam02080
425104012015	Transporter associated domain; Region: CorC_HlyC; smart01091
425104012016	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
425104012017	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
425104012018	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
425104012019	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104012020	Walker A motif; other site
425104012021	ATP binding site [chemical binding]; other site
425104012022	Walker B motif; other site
425104012023	arginine finger; other site
425104012024	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
425104012025	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
425104012026	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
425104012027	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
425104012028	Predicted ATPase [General function prediction only]; Region: COG1485
425104012029	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
425104012030	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104012031	dimerization interface [polypeptide binding]; other site
425104012032	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104012033	dimer interface [polypeptide binding]; other site
425104012034	putative CheW interface [polypeptide binding]; other site
425104012035	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
425104012036	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104012037	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
425104012038	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
425104012039	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
425104012040	metal binding triad; other site
425104012041	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
425104012042	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
425104012043	metal binding triad; other site
425104012044	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
425104012045	spermidine synthase; Provisional; Region: PRK03612
425104012046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104012047	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938
425104012048	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
425104012049	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
425104012050	Ion transport protein; Region: Ion_trans; pfam00520
425104012051	Ion channel; Region: Ion_trans_2; pfam07885
425104012052	Uncharacterized conserved protein [Function unknown]; Region: COG3025
425104012053	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
425104012054	putative active site [active]
425104012055	putative metal binding residues [ion binding]; other site
425104012056	signature motif; other site
425104012057	putative triphosphate binding site [ion binding]; other site
425104012058	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
425104012059	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
425104012060	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
425104012061	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
425104012062	Bacterial SH3 domain homologues; Region: SH3b; smart00287
425104012063	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
425104012064	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
425104012065	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
425104012066	Glutamate binding site [chemical binding]; other site
425104012067	NAD binding site [chemical binding]; other site
425104012068	catalytic residues [active]
425104012069	Helix-turn-helix domain; Region: HTH_17; pfam12728
425104012070	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
425104012071	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
425104012072	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104012073	Walker A/P-loop; other site
425104012074	ATP binding site [chemical binding]; other site
425104012075	Q-loop/lid; other site
425104012076	ABC transporter signature motif; other site
425104012077	Walker B; other site
425104012078	D-loop; other site
425104012079	H-loop/switch region; other site
425104012080	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
425104012081	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
425104012082	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104012083	Walker A/P-loop; other site
425104012084	ATP binding site [chemical binding]; other site
425104012085	Q-loop/lid; other site
425104012086	ABC transporter signature motif; other site
425104012087	Walker B; other site
425104012088	D-loop; other site
425104012089	H-loop/switch region; other site
425104012090	Protein of unknown function (DUF3622); Region: DUF3622; pfam12286
425104012091	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
425104012092	DEAD-like helicases superfamily; Region: DEXDc; smart00487
425104012093	ATP binding site [chemical binding]; other site
425104012094	Mg++ binding site [ion binding]; other site
425104012095	motif III; other site
425104012096	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104012097	nucleotide binding region [chemical binding]; other site
425104012098	ATP-binding site [chemical binding]; other site
425104012099	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
425104012100	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
425104012101	ATP binding site [chemical binding]; other site
425104012102	Mg++ binding site [ion binding]; other site
425104012103	motif III; other site
425104012104	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104012105	nucleotide binding region [chemical binding]; other site
425104012106	ATP-binding site [chemical binding]; other site
425104012107	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
425104012108	putative RNA binding site [nucleotide binding]; other site
425104012109	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
425104012110	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104012111	putative substrate translocation pore; other site
425104012112	Cache domain; Region: Cache_1; pfam02743
425104012113	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104012114	dimerization interface [polypeptide binding]; other site
425104012115	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104012116	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104012117	dimer interface [polypeptide binding]; other site
425104012118	putative CheW interface [polypeptide binding]; other site
425104012119	Helix-turn-helix domain; Region: HTH_18; pfam12833
425104012120	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
425104012121	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
425104012122	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
425104012123	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
425104012124	heme-binding residues [chemical binding]; other site
425104012125	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
425104012126	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
425104012127	non-specific DNA binding site [nucleotide binding]; other site
425104012128	salt bridge; other site
425104012129	sequence-specific DNA binding site [nucleotide binding]; other site
425104012130	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
425104012131	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
425104012132	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104012133	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104012134	ABC transporter; Region: ABC_tran_2; pfam12848
425104012135	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
425104012136	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
425104012137	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
425104012138	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
425104012139	putative hydrolase; Provisional; Region: PRK10985
425104012140	Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180
425104012141	phosphoribulokinase; Provisional; Region: PRK15453
425104012142	active site
425104012143	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
425104012144	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
425104012145	carboxyltransferase (CT) interaction site; other site
425104012146	biotinylation site [posttranslational modification]; other site
425104012147	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104012148	Outer membrane efflux protein; Region: OEP; pfam02321
425104012149	Outer membrane efflux protein; Region: OEP; pfam02321
425104012150	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
425104012151	Sel1-like repeats; Region: SEL1; smart00671
425104012152	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
425104012153	TPR motif; other site
425104012154	binding surface
425104012155	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
425104012156	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
425104012157	ligand binding site [chemical binding]; other site
425104012158	flexible hinge region; other site
425104012159	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
425104012160	putative switch regulator; other site
425104012161	non-specific DNA interactions [nucleotide binding]; other site
425104012162	DNA binding site [nucleotide binding]
425104012163	sequence specific DNA binding site [nucleotide binding]; other site
425104012164	putative cAMP binding site [chemical binding]; other site
425104012165	Predicted membrane protein [Function unknown]; Region: COG3212
425104012166	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
425104012167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104012168	active site
425104012169	phosphorylation site [posttranslational modification]
425104012170	intermolecular recognition site; other site
425104012171	dimerization interface [polypeptide binding]; other site
425104012172	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104012173	DNA binding site [nucleotide binding]
425104012174	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104012175	HAMP domain; Region: HAMP; pfam00672
425104012176	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104012177	ATP binding site [chemical binding]; other site
425104012178	Mg2+ binding site [ion binding]; other site
425104012179	G-X-G motif; other site
425104012180	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
425104012181	heme-binding residues [chemical binding]; other site
425104012182	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
425104012183	L-aspartate oxidase; Provisional; Region: PRK06175
425104012184	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104012185	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104012186	substrate binding pocket [chemical binding]; other site
425104012187	membrane-bound complex binding site; other site
425104012188	hinge residues; other site
425104012189	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
425104012190	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104012191	dimer interface [polypeptide binding]; other site
425104012192	phosphorylation site [posttranslational modification]
425104012193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104012194	ATP binding site [chemical binding]; other site
425104012195	Mg2+ binding site [ion binding]; other site
425104012196	G-X-G motif; other site
425104012197	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
425104012198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104012199	active site
425104012200	phosphorylation site [posttranslational modification]
425104012201	intermolecular recognition site; other site
425104012202	dimerization interface [polypeptide binding]; other site
425104012203	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104012204	Walker A motif; other site
425104012205	ATP binding site [chemical binding]; other site
425104012206	Walker B motif; other site
425104012207	arginine finger; other site
425104012208	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104012209	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104012210	dimerization interface [polypeptide binding]; other site
425104012211	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104012212	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104012213	dimer interface [polypeptide binding]; other site
425104012214	phosphorylation site [posttranslational modification]
425104012215	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104012216	ATP binding site [chemical binding]; other site
425104012217	Mg2+ binding site [ion binding]; other site
425104012218	G-X-G motif; other site
425104012219	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
425104012220	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
425104012221	putative ligand binding site [chemical binding]; other site
425104012222	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
425104012223	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
425104012224	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
425104012225	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
425104012226	amino acid carrier protein; Region: agcS; TIGR00835
425104012227	Protein of unknown function (DUF3581); Region: DUF3581; pfam12119
425104012228	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
425104012229	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104012230	N-terminal plug; other site
425104012231	ligand-binding site [chemical binding]; other site
425104012232	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
425104012233	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104012234	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
425104012235	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
425104012236	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
425104012237	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
425104012238	Transglycosylase; Region: Transgly; pfam00912
425104012239	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
425104012240	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
425104012241	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104012242	ATP binding site [chemical binding]; other site
425104012243	putative Mg++ binding site [ion binding]; other site
425104012244	helicase superfamily c-terminal domain; Region: HELICc; smart00490
425104012245	nucleotide binding region [chemical binding]; other site
425104012246	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
425104012247	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
425104012248	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
425104012249	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
425104012250	aminopeptidase B; Provisional; Region: PRK05015
425104012251	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
425104012252	interface (dimer of trimers) [polypeptide binding]; other site
425104012253	Substrate-binding/catalytic site; other site
425104012254	Zn-binding sites [ion binding]; other site
425104012255	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
425104012256	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
425104012257	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
425104012258	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
425104012259	active site
425104012260	HIGH motif; other site
425104012261	nucleotide binding site [chemical binding]; other site
425104012262	active site
425104012263	KMSKS motif; other site
425104012264	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
425104012265	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
425104012266	active site
425104012267	NTP binding site [chemical binding]; other site
425104012268	metal binding triad [ion binding]; metal-binding site
425104012269	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
425104012270	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
425104012271	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
425104012272	catalytic center binding site [active]
425104012273	ATP binding site [chemical binding]; other site
425104012274	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
425104012275	oligomerization interface [polypeptide binding]; other site
425104012276	active site
425104012277	metal binding site [ion binding]; metal-binding site
425104012278	Pantoate-beta-alanine ligase; Region: PanC; cd00560
425104012279	pantoate--beta-alanine ligase; Region: panC; TIGR00018
425104012280	active site
425104012281	ATP-binding site [chemical binding]; other site
425104012282	pantoate-binding site; other site
425104012283	HXXH motif; other site
425104012284	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
425104012285	protein structure with unknown function; Region: DUF4144; pfam13642
425104012286	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
425104012287	inner membrane transport permease; Provisional; Region: PRK15066
425104012288	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
425104012289	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
425104012290	Walker A/P-loop; other site
425104012291	ATP binding site [chemical binding]; other site
425104012292	Q-loop/lid; other site
425104012293	ABC transporter signature motif; other site
425104012294	Walker B; other site
425104012295	D-loop; other site
425104012296	H-loop/switch region; other site
425104012297	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
425104012298	active site
425104012299	aromatic acid decarboxylase; Validated; Region: PRK05920
425104012300	Flavoprotein; Region: Flavoprotein; pfam02441
425104012301	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
425104012302	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
425104012303	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
425104012304	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
425104012305	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
425104012306	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
425104012307	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
425104012308	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104012309	active site
425104012310	phosphorylation site [posttranslational modification]
425104012311	intermolecular recognition site; other site
425104012312	dimerization interface [polypeptide binding]; other site
425104012313	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104012314	Zn2+ binding site [ion binding]; other site
425104012315	Mg2+ binding site [ion binding]; other site
425104012316	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
425104012317	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
425104012318	substrate binding site [chemical binding]; other site
425104012319	tetramer interface [polypeptide binding]; other site
425104012320	catalytic residue [active]
425104012321	Uncharacterized conserved protein [Function unknown]; Region: COG2968
425104012322	oxidative stress defense protein; Provisional; Region: PRK11087
425104012323	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
425104012324	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
425104012325	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
425104012326	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104012327	substrate binding pocket [chemical binding]; other site
425104012328	membrane-bound complex binding site; other site
425104012329	hinge residues; other site
425104012330	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104012331	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104012332	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104012333	putative effector binding pocket; other site
425104012334	dimerization interface [polypeptide binding]; other site
425104012335	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
425104012336	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
425104012337	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
425104012338	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
425104012339	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
425104012340	Cysteine-rich domain; Region: CCG; pfam02754
425104012341	Cysteine-rich domain; Region: CCG; pfam02754
425104012342	FOG: WD40 repeat [General function prediction only]; Region: COG2319
425104012343	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
425104012344	structural tetrad; other site
425104012345	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
425104012346	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104012347	Coenzyme A binding pocket [chemical binding]; other site
425104012348	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
425104012349	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
425104012350	inhibitor-cofactor binding pocket; inhibition site
425104012351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104012352	catalytic residue [active]
425104012353	succinic semialdehyde dehydrogenase; Region: PLN02278
425104012354	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
425104012355	tetramerization interface [polypeptide binding]; other site
425104012356	NAD(P) binding site [chemical binding]; other site
425104012357	catalytic residues [active]
425104012358	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104012359	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104012360	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
425104012361	dimerization interface [polypeptide binding]; other site
425104012362	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
425104012363	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104012364	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104012365	substrate binding pocket [chemical binding]; other site
425104012366	membrane-bound complex binding site; other site
425104012367	hinge residues; other site
425104012368	Protein of unknown function (DUF3087); Region: DUF3087; pfam11286
425104012369	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
425104012370	Protein of unknown function (DUF998); Region: DUF998; pfam06197
425104012371	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
425104012372	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
425104012373	active site
425104012374	Peptidase S46; Region: Peptidase_S46; pfam10459
425104012375	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
425104012376	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
425104012377	aromatic amino acid transport protein; Region: araaP; TIGR00837
425104012378	Predicted membrane protein [Function unknown]; Region: COG2119
425104012379	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
425104012380	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
425104012381	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
425104012382	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
425104012383	tetramer interface [polypeptide binding]; other site
425104012384	heme binding pocket [chemical binding]; other site
425104012385	NADPH binding site [chemical binding]; other site
425104012386	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
425104012387	CoenzymeA binding site [chemical binding]; other site
425104012388	subunit interaction site [polypeptide binding]; other site
425104012389	PHB binding site; other site
425104012390	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
425104012391	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
425104012392	generic binding surface I; other site
425104012393	generic binding surface II; other site
425104012394	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
425104012395	putative catalytic site [active]
425104012396	putative metal binding site [ion binding]; other site
425104012397	putative phosphate binding site [ion binding]; other site
425104012398	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
425104012399	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
425104012400	generic binding surface II; other site
425104012401	generic binding surface I; other site
425104012402	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
425104012403	putative catalytic site [active]
425104012404	putative metal binding site [ion binding]; other site
425104012405	putative phosphate binding site [ion binding]; other site
425104012406	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
425104012407	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104012408	DNA binding residues [nucleotide binding]
425104012409	dimerization interface [polypeptide binding]; other site
425104012410	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
425104012411	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
425104012412	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
425104012413	ligand binding site [chemical binding]; other site
425104012414	NAD binding site [chemical binding]; other site
425104012415	tetramer interface [polypeptide binding]; other site
425104012416	catalytic site [active]
425104012417	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
425104012418	L-serine binding site [chemical binding]; other site
425104012419	ACT domain interface; other site
425104012420	putative global regulator; Reviewed; Region: PRK09559
425104012421	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
425104012422	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
425104012423	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
425104012424	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
425104012425	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
425104012426	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
425104012427	catalytic residues [active]
425104012428	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
425104012429	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
425104012430	Walker A/P-loop; other site
425104012431	ATP binding site [chemical binding]; other site
425104012432	Q-loop/lid; other site
425104012433	ABC transporter signature motif; other site
425104012434	Walker B; other site
425104012435	D-loop; other site
425104012436	H-loop/switch region; other site
425104012437	FtsX-like permease family; Region: FtsX; pfam02687
425104012438	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
425104012439	NapD protein; Region: NapD; pfam03927
425104012440	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
425104012441	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
425104012442	[4Fe-4S] binding site [ion binding]; other site
425104012443	molybdopterin cofactor binding site; other site
425104012444	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
425104012445	molybdopterin cofactor binding site; other site
425104012446	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
425104012447	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
425104012448	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
425104012449	4Fe-4S binding domain; Region: Fer4_5; pfam12801
425104012450	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
425104012451	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104012452	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104012453	metal binding site [ion binding]; metal-binding site
425104012454	active site
425104012455	I-site; other site
425104012456	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
425104012457	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
425104012458	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
425104012459	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
425104012460	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104012461	motif II; other site
425104012462	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
425104012463	universal stress protein UspE; Provisional; Region: PRK11175
425104012464	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
425104012465	Ligand Binding Site [chemical binding]; other site
425104012466	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
425104012467	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
425104012468	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
425104012469	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
425104012470	ATP-grasp domain; Region: ATP-grasp_4; cl17255
425104012471	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
425104012472	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
425104012473	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
425104012474	ATP-grasp domain; Region: ATP-grasp_4; cl17255
425104012475	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
425104012476	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
425104012477	carboxyltransferase (CT) interaction site; other site
425104012478	biotinylation site [posttranslational modification]; other site
425104012479	LysR family transcriptional regulator; Provisional; Region: PRK14997
425104012480	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104012481	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104012482	putative effector binding pocket; other site
425104012483	dimerization interface [polypeptide binding]; other site
425104012484	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
425104012485	putative substrate binding pocket [chemical binding]; other site
425104012486	AC domain interface; other site
425104012487	catalytic triad [active]
425104012488	AB domain interface; other site
425104012489	interchain disulfide; other site
425104012490	hypothetical protein; Provisional; Region: PRK04860
425104012491	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
425104012492	Endonuclease I; Region: Endonuclease_1; pfam04231
425104012493	RNA methyltransferase, RsmE family; Region: TIGR00046
425104012494	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
425104012495	glutathione synthetase; Provisional; Region: PRK05246
425104012496	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
425104012497	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
425104012498	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
425104012499	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
425104012500	active site
425104012501	dimer interface [polypeptide binding]; other site
425104012502	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104012503	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104012504	metal binding site [ion binding]; metal-binding site
425104012505	active site
425104012506	I-site; other site
425104012507	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104012508	PBP superfamily domain; Region: PBP_like_2; cl17296
425104012509	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
425104012510	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
425104012511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104012512	S-adenosylmethionine binding site [chemical binding]; other site
425104012513	Protein of unknown function (DUF342); Region: DUF342; pfam03961
425104012514	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
425104012515	Peptidase family M50; Region: Peptidase_M50; pfam02163
425104012516	active site
425104012517	putative substrate binding region [chemical binding]; other site
425104012518	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104012519	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104012520	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104012521	tetrathionate reductase subunit A; Provisional; Region: PRK14991
425104012522	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
425104012523	putative [Fe4-S4] binding site [ion binding]; other site
425104012524	putative molybdopterin cofactor binding site [chemical binding]; other site
425104012525	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
425104012526	putative molybdopterin cofactor binding site; other site
425104012527	tetrathionate reductase subunit B; Provisional; Region: PRK14993
425104012528	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
425104012529	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
425104012530	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
425104012531	Uncharacterized conserved protein [Function unknown]; Region: COG5361
425104012532	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
425104012533	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
425104012534	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
425104012535	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104012536	FeS/SAM binding site; other site
425104012537	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
425104012538	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104012539	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104012540	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
425104012541	substrate binding pocket [chemical binding]; other site
425104012542	dimerization interface [polypeptide binding]; other site
425104012543	Uncharacterized conserved protein [Function unknown]; Region: COG5361
425104012544	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
425104012545	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
425104012546	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
425104012547	Sulfatase; Region: Sulfatase; pfam00884
425104012548	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
425104012549	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104012550	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104012551	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104012552	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104012553	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
425104012554	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
425104012555	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104012556	DNA binding residues [nucleotide binding]
425104012557	dimerization interface [polypeptide binding]; other site
425104012558	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104012559	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104012560	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104012561	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104012562	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
425104012563	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
425104012564	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
425104012565	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
425104012566	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
425104012567	Superinfection exclusion protein B; Region: SieB; pfam14163
425104012568	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
425104012569	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
425104012570	dimer interface [polypeptide binding]; other site
425104012571	phosphorylation site [posttranslational modification]
425104012572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104012573	ATP binding site [chemical binding]; other site
425104012574	Mg2+ binding site [ion binding]; other site
425104012575	G-X-G motif; other site
425104012576	peptidase T; Region: peptidase-T; TIGR01882
425104012577	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
425104012578	metal binding site [ion binding]; metal-binding site
425104012579	dimer interface [polypeptide binding]; other site
425104012580	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
425104012581	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
425104012582	putative ATP binding site [chemical binding]; other site
425104012583	putative substrate interface [chemical binding]; other site
425104012584	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
425104012585	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
425104012586	eyelet of channel; other site
425104012587	trimer interface [polypeptide binding]; other site
425104012588	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
425104012589	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
425104012590	eyelet of channel; other site
425104012591	trimer interface [polypeptide binding]; other site
425104012592	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
425104012593	Catalytic domain of Protein Kinases; Region: PKc; cd00180
425104012594	active site
425104012595	ATP binding site [chemical binding]; other site
425104012596	substrate binding site [chemical binding]; other site
425104012597	activation loop (A-loop); other site
425104012598	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
425104012599	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
425104012600	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
425104012601	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
425104012602	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
425104012603	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
425104012604	DsbD alpha interface [polypeptide binding]; other site
425104012605	catalytic residues [active]
425104012606	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
425104012607	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
425104012608	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
425104012609	TrkA-N domain; Region: TrkA_N; pfam02254
425104012610	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
425104012611	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
425104012612	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
425104012613	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
425104012614	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
425104012615	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
425104012616	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
425104012617	Na binding site [ion binding]; other site
425104012618	galactokinase; Provisional; Region: PRK05101
425104012619	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
425104012620	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
425104012621	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
425104012622	active site
425104012623	catalytic residues [active]
425104012624	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
425104012625	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
425104012626	NAD(P) binding site [chemical binding]; other site
425104012627	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
425104012628	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
425104012629	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
425104012630	dimer interface [polypeptide binding]; other site
425104012631	ssDNA binding site [nucleotide binding]; other site
425104012632	tetramer (dimer of dimers) interface [polypeptide binding]; other site
425104012633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104012634	Major Facilitator Superfamily; Region: MFS_1; pfam07690
425104012635	putative substrate translocation pore; other site
425104012636	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
425104012637	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
425104012638	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
425104012639	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
425104012640	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
425104012641	Peptidase family M28; Region: Peptidase_M28; pfam04389
425104012642	metal binding site [ion binding]; metal-binding site
425104012643	helicase 45; Provisional; Region: PTZ00424
425104012644	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
425104012645	ATP binding site [chemical binding]; other site
425104012646	Mg++ binding site [ion binding]; other site
425104012647	motif III; other site
425104012648	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104012649	nucleotide binding region [chemical binding]; other site
425104012650	ATP-binding site [chemical binding]; other site
425104012651	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
425104012652	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
425104012653	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
425104012654	Zn binding site [ion binding]; other site
425104012655	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
425104012656	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
425104012657	MarR family; Region: MarR_2; cl17246
425104012658	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
425104012659	Sel1-like repeats; Region: SEL1; smart00671
425104012660	Sel1-like repeats; Region: SEL1; smart00671
425104012661	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
425104012662	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
425104012663	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
425104012664	FAD binding site [chemical binding]; other site
425104012665	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
425104012666	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
425104012667	nucleotide binding site [chemical binding]; other site
425104012668	substrate binding site [chemical binding]; other site
425104012669	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
425104012670	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
425104012671	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
425104012672	homodimer interface [polypeptide binding]; other site
425104012673	substrate-cofactor binding pocket; other site
425104012674	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104012675	catalytic residue [active]
425104012676	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
425104012677	dimerization interface [polypeptide binding]; other site
425104012678	DNA binding site [nucleotide binding]
425104012679	corepressor binding sites; other site
425104012680	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
425104012681	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
425104012682	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
425104012683	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
425104012684	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
425104012685	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
425104012686	thiosulfate reductase PhsA; Provisional; Region: PRK15488
425104012687	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
425104012688	putative [Fe4-S4] binding site [ion binding]; other site
425104012689	putative molybdopterin cofactor binding site [chemical binding]; other site
425104012690	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
425104012691	putative molybdopterin cofactor binding site; other site
425104012692	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
425104012693	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104012694	FeS/SAM binding site; other site
425104012695	Protein of unknown function, DUF547; Region: DUF547; pfam04784
425104012696	Methyltransferase domain; Region: Methyltransf_31; pfam13847
425104012697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104012698	S-adenosylmethionine binding site [chemical binding]; other site
425104012699	Domain of unknown function (DUF1971); Region: DUF1971; cl17717
425104012700	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
425104012701	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
425104012702	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
425104012703	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
425104012704	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
425104012705	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
425104012706	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
425104012707	iron binding site [ion binding]; other site
425104012708	Methyltransferase domain; Region: Methyltransf_31; pfam13847
425104012709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104012710	S-adenosylmethionine binding site [chemical binding]; other site
425104012711	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104012712	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104012713	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104012714	putative effector binding pocket; other site
425104012715	dimerization interface [polypeptide binding]; other site
425104012716	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
425104012717	classical (c) SDRs; Region: SDR_c; cd05233
425104012718	NAD(P) binding site [chemical binding]; other site
425104012719	active site
425104012720	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
425104012721	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
425104012722	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
425104012723	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
425104012724	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
425104012725	Flagellin N-methylase; Region: FliB; pfam03692
425104012726	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
425104012727	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
425104012728	FMN binding site [chemical binding]; other site
425104012729	active site
425104012730	substrate binding site [chemical binding]; other site
425104012731	catalytic residue [active]
425104012732	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104012733	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104012734	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104012735	putative effector binding pocket; other site
425104012736	dimerization interface [polypeptide binding]; other site
425104012737	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
425104012738	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
425104012739	dimer interface [polypeptide binding]; other site
425104012740	phosphorylation site [posttranslational modification]
425104012741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104012742	ATP binding site [chemical binding]; other site
425104012743	Mg2+ binding site [ion binding]; other site
425104012744	G-X-G motif; other site
425104012745	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
425104012746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104012747	active site
425104012748	phosphorylation site [posttranslational modification]
425104012749	intermolecular recognition site; other site
425104012750	dimerization interface [polypeptide binding]; other site
425104012751	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
425104012752	DNA binding residues [nucleotide binding]
425104012753	dimerization interface [polypeptide binding]; other site
425104012754	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
425104012755	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104012756	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104012757	metal binding site [ion binding]; metal-binding site
425104012758	active site
425104012759	I-site; other site
425104012760	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
425104012761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104012762	active site
425104012763	phosphorylation site [posttranslational modification]
425104012764	intermolecular recognition site; other site
425104012765	dimerization interface [polypeptide binding]; other site
425104012766	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
425104012767	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104012768	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104012769	ATP binding site [chemical binding]; other site
425104012770	Mg2+ binding site [ion binding]; other site
425104012771	G-X-G motif; other site
425104012772	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
425104012773	metal binding site [ion binding]; metal-binding site
425104012774	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
425104012775	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
425104012776	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
425104012777	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
425104012778	active site
425104012779	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
425104012780	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
425104012781	Domain of unknown function (DUF386); Region: DUF386; cl01047
425104012782	Putative phosphatase (DUF442); Region: DUF442; cl17385
425104012783	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
425104012784	active site residue [active]
425104012785	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
425104012786	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
425104012787	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104012788	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
425104012789	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104012790	Outer membrane efflux protein; Region: OEP; pfam02321
425104012791	Protein of unknown function (DUF3012); Region: DUF3012; pfam11216
425104012792	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
425104012793	hypothetical protein; Provisional; Region: PRK09256
425104012794	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
425104012795	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
425104012796	Dehydroquinase class II; Region: DHquinase_II; pfam01220
425104012797	active site
425104012798	trimer interface [polypeptide binding]; other site
425104012799	dimer interface [polypeptide binding]; other site
425104012800	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
425104012801	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
425104012802	carboxyltransferase (CT) interaction site; other site
425104012803	biotinylation site [posttranslational modification]; other site
425104012804	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
425104012805	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
425104012806	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
425104012807	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
425104012808	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104012809	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104012810	substrate binding pocket [chemical binding]; other site
425104012811	membrane-bound complex binding site; other site
425104012812	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
425104012813	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
425104012814	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
425104012815	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
425104012816	putative active site [active]
425104012817	putative metal binding site [ion binding]; other site
425104012818	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
425104012819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104012820	S-adenosylmethionine binding site [chemical binding]; other site
425104012821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
425104012822	SCP-2 sterol transfer family; Region: SCP2; pfam02036
425104012823	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
425104012824	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
425104012825	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
425104012826	sec-independent translocase; Provisional; Region: PRK01770
425104012827	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
425104012828	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
425104012829	active site
425104012830	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
425104012831	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
425104012832	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104012833	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104012834	metal binding site [ion binding]; metal-binding site
425104012835	active site
425104012836	I-site; other site
425104012837	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
425104012838	dimer interface [polypeptide binding]; other site
425104012839	allosteric magnesium binding site [ion binding]; other site
425104012840	active site
425104012841	aspartate-rich active site metal binding site; other site
425104012842	Schiff base residues; other site
425104012843	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
425104012844	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
425104012845	catalytic residues [active]
425104012846	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
425104012847	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104012848	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
425104012849	exopolyphosphatase; Region: exo_poly_only; TIGR03706
425104012850	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
425104012851	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
425104012852	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
425104012853	ATP binding site [chemical binding]; other site
425104012854	Mg++ binding site [ion binding]; other site
425104012855	motif III; other site
425104012856	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104012857	nucleotide binding region [chemical binding]; other site
425104012858	ATP-binding site [chemical binding]; other site
425104012859	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
425104012860	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
425104012861	catalytic residues [active]
425104012862	transcription termination factor Rho; Provisional; Region: rho; PRK09376
425104012863	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
425104012864	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
425104012865	RNA binding site [nucleotide binding]; other site
425104012866	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
425104012867	multimer interface [polypeptide binding]; other site
425104012868	Walker A motif; other site
425104012869	ATP binding site [chemical binding]; other site
425104012870	Walker B motif; other site
425104012871	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104012872	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104012873	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
425104012874	putative effector binding pocket; other site
425104012875	dimerization interface [polypeptide binding]; other site
425104012876	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
425104012877	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
425104012878	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
425104012879	L-aspartate oxidase; Provisional; Region: PRK06175
425104012880	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
425104012881	Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581
425104012882	Iron-sulfur protein interface; other site
425104012883	proximal heme binding site [chemical binding]; other site
425104012884	distal heme binding site [chemical binding]; other site
425104012885	dimer interface [polypeptide binding]; other site
425104012886	fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13554
425104012887	Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581
425104012888	Iron-sulfur protein interface; other site
425104012889	proximal heme binding site [chemical binding]; other site
425104012890	distal heme binding site [chemical binding]; other site
425104012891	dimer interface [polypeptide binding]; other site
425104012892	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
425104012893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104012894	S-adenosylmethionine binding site [chemical binding]; other site
425104012895	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
425104012896	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
425104012897	FMN binding site [chemical binding]; other site
425104012898	active site
425104012899	catalytic residues [active]
425104012900	substrate binding site [chemical binding]; other site
425104012901	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
425104012902	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
425104012903	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
425104012904	reductive dehalogenase; Region: RDH; TIGR02486
425104012905	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
425104012906	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
425104012907	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
425104012908	Cytochrome C' Region: Cytochrom_C_2; pfam01322
425104012909	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104012910	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104012911	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
425104012912	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
425104012913	Hemerythrin-like domain; Region: Hr-like; cd12108
425104012914	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
425104012915	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
425104012916	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104012917	motif II; other site
425104012918	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
425104012919	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
425104012920	active site
425104012921	Int/Topo IB signature motif; other site
425104012922	Protein of unknown function, DUF484; Region: DUF484; cl17449
425104012923	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
425104012924	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
425104012925	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
425104012926	diaminopimelate decarboxylase; Region: lysA; TIGR01048
425104012927	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
425104012928	active site
425104012929	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
425104012930	substrate binding site [chemical binding]; other site
425104012931	catalytic residues [active]
425104012932	dimer interface [polypeptide binding]; other site
425104012933	Frataxin-like domain; Region: Frataxin_Cyay; pfam01491
425104012934	putative iron binding site [ion binding]; other site
425104012935	adenylate cyclase; Provisional; Region: cyaA; PRK09450
425104012936	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
425104012937	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
425104012938	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
425104012939	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
425104012940	domain interfaces; other site
425104012941	active site
425104012942	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
425104012943	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
425104012944	active site
425104012945	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
425104012946	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
425104012947	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
425104012948	HemY protein N-terminus; Region: HemY_N; pfam07219
425104012949	N-terminal protein-binding module of harmonin and similar domains; Region: harmonin_N_like; cl11968
425104012950	putative protein binding pocket; other site
425104012951	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012952	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012953	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012954	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
425104012955	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012956	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012957	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012958	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012959	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012960	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012961	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012962	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012963	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012964	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012965	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012966	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012967	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012968	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012969	VCBS repeat; Region: VCBS_repeat; TIGR01965
425104012970	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
425104012971	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
425104012972	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
425104012973	metal ion-dependent adhesion site (MIDAS); other site
425104012974	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
425104012975	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
425104012976	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
425104012977	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
425104012978	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
425104012979	Walker A/P-loop; other site
425104012980	ATP binding site [chemical binding]; other site
425104012981	Q-loop/lid; other site
425104012982	ABC transporter signature motif; other site
425104012983	Walker B; other site
425104012984	D-loop; other site
425104012985	H-loop/switch region; other site
425104012986	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
425104012987	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
425104012988	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104012989	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
425104012990	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
425104012991	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
425104012992	ligand binding site [chemical binding]; other site
425104012993	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
425104012994	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104012995	dimerization interface [polypeptide binding]; other site
425104012996	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104012997	metal binding site [ion binding]; metal-binding site
425104012998	active site
425104012999	I-site; other site
425104013000	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104013001	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
425104013002	GAF domain; Region: GAF; pfam01590
425104013003	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
425104013004	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
425104013005	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104013006	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104013007	metal binding site [ion binding]; metal-binding site
425104013008	active site
425104013009	I-site; other site
425104013010	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104013011	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
425104013012	Part of AAA domain; Region: AAA_19; pfam13245
425104013013	Family description; Region: UvrD_C_2; pfam13538
425104013014	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104013015	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104013016	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104013017	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104013018	multidrug efflux protein; Reviewed; Region: PRK09579
425104013019	Protein export membrane protein; Region: SecD_SecF; cl14618
425104013020	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
425104013021	Protein of unknown function, DUF417; Region: DUF417; cl01162
425104013022	inner membrane protein; Provisional; Region: PRK11715
425104013023	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
425104013024	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
425104013025	active site
425104013026	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
425104013027	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
425104013028	putative DNA binding site [nucleotide binding]; other site
425104013029	putative Zn2+ binding site [ion binding]; other site
425104013030	AsnC family; Region: AsnC_trans_reg; pfam01037
425104013031	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
425104013032	Na2 binding site [ion binding]; other site
425104013033	putative substrate binding site 1 [chemical binding]; other site
425104013034	Na binding site 1 [ion binding]; other site
425104013035	putative substrate binding site 2 [chemical binding]; other site
425104013036	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
425104013037	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104013038	N-terminal plug; other site
425104013039	ligand-binding site [chemical binding]; other site
425104013040	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
425104013041	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
425104013042	Beta-Casp domain; Region: Beta-Casp; smart01027
425104013043	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
425104013044	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
425104013045	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
425104013046	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
425104013047	homodimer interface [polypeptide binding]; other site
425104013048	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104013049	catalytic residue [active]
425104013050	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
425104013051	tetramer interface [polypeptide binding]; other site
425104013052	threonine dehydratase; Reviewed; Region: PRK09224
425104013053	pyridoxal 5'-phosphate binding site [chemical binding]; other site
425104013054	catalytic residue [active]
425104013055	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
425104013056	putative Ile/Val binding site [chemical binding]; other site
425104013057	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
425104013058	putative Ile/Val binding site [chemical binding]; other site
425104013059	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
425104013060	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
425104013061	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
425104013062	homodimer interface [polypeptide binding]; other site
425104013063	substrate-cofactor binding pocket; other site
425104013064	catalytic residue [active]
425104013065	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
425104013066	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
425104013067	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
425104013068	PYR/PP interface [polypeptide binding]; other site
425104013069	dimer interface [polypeptide binding]; other site
425104013070	TPP binding site [chemical binding]; other site
425104013071	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
425104013072	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
425104013073	TPP-binding site [chemical binding]; other site
425104013074	dimer interface [polypeptide binding]; other site
425104013075	ketol-acid reductoisomerase; Validated; Region: PRK05225
425104013076	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
425104013077	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
425104013078	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
425104013079	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104013080	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
425104013081	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
425104013082	putative dimerization interface [polypeptide binding]; other site
425104013083	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104013084	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104013085	substrate binding pocket [chemical binding]; other site
425104013086	membrane-bound complex binding site; other site
425104013087	hinge residues; other site
425104013088	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104013089	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104013090	metal binding site [ion binding]; metal-binding site
425104013091	active site
425104013092	I-site; other site
425104013093	serine acetyltransferase; Provisional; Region: cysE; PRK11132
425104013094	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
425104013095	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
425104013096	trimer interface [polypeptide binding]; other site
425104013097	active site
425104013098	substrate binding site [chemical binding]; other site
425104013099	CoA binding site [chemical binding]; other site
425104013100	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
425104013101	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
425104013102	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
425104013103	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
425104013104	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
425104013105	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
425104013106	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
425104013107	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
425104013108	putative acyl-acceptor binding pocket; other site
425104013109	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
425104013110	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
425104013111	putative acyl-acceptor binding pocket; other site
425104013112	Transcriptional regulators [Transcription]; Region: GntR; COG1802
425104013113	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
425104013114	DNA-binding site [nucleotide binding]; DNA binding site
425104013115	FCD domain; Region: FCD; pfam07729
425104013116	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
425104013117	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
425104013118	homodimer interface [polypeptide binding]; other site
425104013119	substrate-cofactor binding pocket; other site
425104013120	catalytic residue [active]
425104013121	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104013122	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104013123	Predicted oxidoreductase [General function prediction only]; Region: COG3573
425104013124	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
425104013125	L-aspartate oxidase; Provisional; Region: PRK06175
425104013126	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
425104013127	heme-binding residues [chemical binding]; other site
425104013128	Cupin domain; Region: Cupin_2; pfam07883
425104013129	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
425104013130	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104013131	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104013132	L-aspartate oxidase; Provisional; Region: PRK06175
425104013133	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
425104013134	L-aspartate oxidase; Provisional; Region: PRK06175
425104013135	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
425104013136	heme-binding residues [chemical binding]; other site
425104013137	Cupin domain; Region: Cupin_2; pfam07883
425104013138	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
425104013139	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
425104013140	Protein of unknown function (DUF904); Region: DUF904; cl11531
425104013141	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
425104013142	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
425104013143	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
425104013144	catalytic residues [active]
425104013145	hinge region; other site
425104013146	alpha helical domain; other site
425104013147	serine/threonine protein kinase; Provisional; Region: PRK11768
425104013148	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
425104013149	Protein of unknown function (DUF3630); Region: DUF3630; pfam12305
425104013150	DsrE/DsrF-like family; Region: DrsE; cl00672
425104013151	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
425104013152	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
425104013153	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104013154	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
425104013155	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
425104013156	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
425104013157	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104013158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
425104013159	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
425104013160	putative substrate translocation pore; other site
425104013161	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
425104013162	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104013163	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
425104013164	putative amphipathic alpha helix; other site
425104013165	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
425104013166	putative active site [active]
425104013167	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
425104013168	putative NTP binding site [chemical binding]; other site
425104013169	putative nucleic acid binding site [nucleotide binding]; other site
425104013170	tetrathionate reductase subunit A; Provisional; Region: PRK14991
425104013171	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
425104013172	putative [Fe4-S4] binding site [ion binding]; other site
425104013173	putative molybdopterin cofactor binding site [chemical binding]; other site
425104013174	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
425104013175	putative molybdopterin cofactor binding site; other site
425104013176	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
425104013177	4Fe-4S binding domain; Region: Fer4; pfam00037
425104013178	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104013179	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104013180	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104013181	dimerization interface [polypeptide binding]; other site
425104013182	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
425104013183	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
425104013184	putative [4Fe-4S] binding site [ion binding]; other site
425104013185	putative molybdopterin cofactor binding site [chemical binding]; other site
425104013186	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
425104013187	molybdopterin cofactor binding site; other site
425104013188	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
425104013189	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
425104013190	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
425104013191	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
425104013192	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
425104013193	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
425104013194	trimer interface [polypeptide binding]; other site
425104013195	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
425104013196	eyelet of channel; other site
425104013197	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104013198	dimerization interface [polypeptide binding]; other site
425104013199	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104013200	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104013201	dimer interface [polypeptide binding]; other site
425104013202	putative CheW interface [polypeptide binding]; other site
425104013203	Uncharacterized conserved protein [Function unknown]; Region: COG3339
425104013204	hypothetical protein; Provisional; Region: PRK01254
425104013205	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
425104013206	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
425104013207	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
425104013208	MAPEG family; Region: MAPEG; cl09190
425104013209	Uncharacterized conserved protein [Function unknown]; Region: COG2966
425104013210	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
425104013211	Uncharacterized conserved protein [Function unknown]; Region: COG3610
425104013212	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
425104013213	Surface antigen; Region: Bac_surface_Ag; pfam01103
425104013214	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104013215	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104013216	substrate binding pocket [chemical binding]; other site
425104013217	membrane-bound complex binding site; other site
425104013218	hinge residues; other site
425104013219	dihydromonapterin reductase; Provisional; Region: PRK06483
425104013220	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
425104013221	NAD(P) binding site [chemical binding]; other site
425104013222	active site
425104013223	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
425104013224	catalytic center binding site [active]
425104013225	ATP binding site [chemical binding]; other site
425104013226	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
425104013227	S-formylglutathione hydrolase; Region: PLN02442
425104013228	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
425104013229	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
425104013230	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
425104013231	substrate binding site [chemical binding]; other site
425104013232	catalytic Zn binding site [ion binding]; other site
425104013233	NAD binding site [chemical binding]; other site
425104013234	structural Zn binding site [ion binding]; other site
425104013235	dimer interface [polypeptide binding]; other site
425104013236	hypothetical protein; Provisional; Region: PRK11019
425104013237	Predicted membrane protein [Function unknown]; Region: COG3431
425104013238	glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417
425104013239	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
425104013240	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
425104013241	dimer interface [polypeptide binding]; other site
425104013242	active site
425104013243	metal binding site [ion binding]; metal-binding site
425104013244	Transcriptional regulator [Transcription]; Region: LysR; COG0583
425104013245	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104013246	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
425104013247	putative effector binding pocket; other site
425104013248	putative dimerization interface [polypeptide binding]; other site
425104013249	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
425104013250	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
425104013251	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
425104013252	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
425104013253	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
425104013254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104013255	dimer interface [polypeptide binding]; other site
425104013256	conserved gate region; other site
425104013257	putative PBP binding loops; other site
425104013258	ABC-ATPase subunit interface; other site
425104013259	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
425104013260	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
425104013261	Walker A/P-loop; other site
425104013262	ATP binding site [chemical binding]; other site
425104013263	Q-loop/lid; other site
425104013264	ABC transporter signature motif; other site
425104013265	Walker B; other site
425104013266	D-loop; other site
425104013267	H-loop/switch region; other site
425104013268	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
425104013269	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
425104013270	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
425104013271	Part of AAA domain; Region: AAA_19; pfam13245
425104013272	AAA domain; Region: AAA_14; pfam13173
425104013273	Family description; Region: UvrD_C_2; pfam13538
425104013274	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
425104013275	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
425104013276	active site
425104013277	DNA binding site [nucleotide binding]
425104013278	Int/Topo IB signature motif; other site
425104013279	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
425104013280	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104013281	Walker A motif; other site
425104013282	ATP binding site [chemical binding]; other site
425104013283	Walker B motif; other site
425104013284	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
425104013285	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
425104013286	Walker A motif; other site
425104013287	ATP binding site [chemical binding]; other site
425104013288	Walker B motif; other site
425104013289	arginine finger; other site
425104013290	Protein of unknown function (DUF2787); Region: DUF2787; pfam10980
425104013291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
425104013292	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
425104013293	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
425104013294	Protein of unknown function DUF3258; Region: DUF3258; pfam11646
425104013295	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
425104013296	active site
425104013297	Int/Topo IB signature motif; other site
425104013298	DNA binding site [nucleotide binding]
425104013299	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
425104013300	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
425104013301	putative SAM binding site [chemical binding]; other site
425104013302	putative homodimer interface [polypeptide binding]; other site
425104013303	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
425104013304	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
425104013305	putative ligand binding site [chemical binding]; other site
425104013306	hypothetical protein; Reviewed; Region: PRK12497
425104013307	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
425104013308	dimer interface [polypeptide binding]; other site
425104013309	active site
425104013310	BON domain; Region: BON; pfam04972
425104013311	BON domain; Region: BON; pfam04972
425104013312	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
425104013313	EamA-like transporter family; Region: EamA; cl17759
425104013314	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
425104013315	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
425104013316	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
425104013317	dimerization interface [polypeptide binding]; other site
425104013318	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
425104013319	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
425104013320	active site
425104013321	HIGH motif; other site
425104013322	dimer interface [polypeptide binding]; other site
425104013323	KMSKS motif; other site
425104013324	phosphoglycolate phosphatase; Provisional; Region: PRK13222
425104013325	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
425104013326	motif I; other site
425104013327	active site
425104013328	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104013329	motif II; other site
425104013330	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
425104013331	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
425104013332	substrate binding site [chemical binding]; other site
425104013333	hexamer interface [polypeptide binding]; other site
425104013334	metal binding site [ion binding]; metal-binding site
425104013335	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
425104013336	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
425104013337	AAA ATPase domain; Region: AAA_16; pfam13191
425104013338	AAA domain; Region: AAA_22; pfam13401
425104013339	Walker A motif; other site
425104013340	ATP binding site [chemical binding]; other site
425104013341	Walker B motif; other site
425104013342	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
425104013343	active site
425104013344	dimer interface [polypeptide binding]; other site
425104013345	metal binding site [ion binding]; metal-binding site
425104013346	shikimate kinase; Reviewed; Region: aroK; PRK00131
425104013347	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
425104013348	ADP binding site [chemical binding]; other site
425104013349	magnesium binding site [ion binding]; other site
425104013350	putative shikimate binding site; other site
425104013351	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
425104013352	Secretin and TonB N terminus short domain; Region: STN; smart00965
425104013353	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
425104013354	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
425104013355	Pilus assembly protein, PilP; Region: PilP; pfam04351
425104013356	Pilus assembly protein, PilO; Region: PilO; pfam04350
425104013357	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
425104013358	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
425104013359	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
425104013360	Competence protein A; Region: Competence_A; pfam11104
425104013361	nucleotide binding site [chemical binding]; other site
425104013362	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
425104013363	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
425104013364	Transglycosylase; Region: Transgly; pfam00912
425104013365	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
425104013366	argininosuccinate lyase; Provisional; Region: PRK04833
425104013367	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
425104013368	active sites [active]
425104013369	tetramer interface [polypeptide binding]; other site
425104013370	argininosuccinate synthase; Provisional; Region: PRK13820
425104013371	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
425104013372	ANP binding site [chemical binding]; other site
425104013373	Substrate Binding Site II [chemical binding]; other site
425104013374	Substrate Binding Site I [chemical binding]; other site
425104013375	ornithine carbamoyltransferase; Provisional; Region: PRK14805
425104013376	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
425104013377	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
425104013378	acetylglutamate kinase; Provisional; Region: PRK00942
425104013379	nucleotide binding site [chemical binding]; other site
425104013380	substrate binding site [chemical binding]; other site
425104013381	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
425104013382	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
425104013383	acetylornithine deacetylase; Provisional; Region: PRK05111
425104013384	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
425104013385	metal binding site [ion binding]; metal-binding site
425104013386	putative dimer interface [polypeptide binding]; other site
425104013387	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
425104013388	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
425104013389	Protein of unknown function (DUF1439); Region: DUF1439; pfam07273
425104013390	competence damage-inducible protein A; Provisional; Region: PRK00549
425104013391	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
425104013392	putative MPT binding site; other site
425104013393	Competence-damaged protein; Region: CinA; pfam02464
425104013394	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
425104013395	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
425104013396	catalytic residues [active]
425104013397	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
425104013398	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
425104013399	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
425104013400	catalytic residues [active]
425104013401	central insert; other site
425104013402	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
425104013403	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
425104013404	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
425104013405	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
425104013406	binding surface
425104013407	TPR motif; other site
425104013408	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
425104013409	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
425104013410	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
425104013411	Walker A/P-loop; other site
425104013412	ATP binding site [chemical binding]; other site
425104013413	Q-loop/lid; other site
425104013414	ABC transporter signature motif; other site
425104013415	Walker B; other site
425104013416	D-loop; other site
425104013417	H-loop/switch region; other site
425104013418	heme exporter protein CcmB; Region: ccmB; TIGR01190
425104013419	heme exporter protein CcmC; Region: ccmC; TIGR01191
425104013420	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
425104013421	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
425104013422	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
425104013423	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
425104013424	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
425104013425	alphaNTD homodimer interface [polypeptide binding]; other site
425104013426	alphaNTD - beta interaction site [polypeptide binding]; other site
425104013427	alphaNTD - beta' interaction site [polypeptide binding]; other site
425104013428	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
425104013429	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
425104013430	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
425104013431	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
425104013432	RNA binding surface [nucleotide binding]; other site
425104013433	30S ribosomal protein S11; Validated; Region: PRK05309
425104013434	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
425104013435	30S ribosomal protein S13; Region: bact_S13; TIGR03631
425104013436	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
425104013437	SecY translocase; Region: SecY; pfam00344
425104013438	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
425104013439	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
425104013440	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
425104013441	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
425104013442	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
425104013443	23S rRNA interface [nucleotide binding]; other site
425104013444	L21e interface [polypeptide binding]; other site
425104013445	5S rRNA interface [nucleotide binding]; other site
425104013446	L27 interface [polypeptide binding]; other site
425104013447	L5 interface [polypeptide binding]; other site
425104013448	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
425104013449	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
425104013450	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
425104013451	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
425104013452	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
425104013453	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
425104013454	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
425104013455	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
425104013456	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
425104013457	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
425104013458	RNA binding site [nucleotide binding]; other site
425104013459	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
425104013460	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
425104013461	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
425104013462	23S rRNA interface [nucleotide binding]; other site
425104013463	putative translocon interaction site; other site
425104013464	signal recognition particle (SRP54) interaction site; other site
425104013465	L23 interface [polypeptide binding]; other site
425104013466	trigger factor interaction site; other site
425104013467	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
425104013468	23S rRNA interface [nucleotide binding]; other site
425104013469	5S rRNA interface [nucleotide binding]; other site
425104013470	putative antibiotic binding site [chemical binding]; other site
425104013471	L25 interface [polypeptide binding]; other site
425104013472	L27 interface [polypeptide binding]; other site
425104013473	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
425104013474	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
425104013475	G-X-X-G motif; other site
425104013476	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
425104013477	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
425104013478	putative translocon binding site; other site
425104013479	protein-rRNA interface [nucleotide binding]; other site
425104013480	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
425104013481	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
425104013482	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
425104013483	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
425104013484	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
425104013485	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
425104013486	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
425104013487	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
425104013488	elongation factor Tu; Reviewed; Region: PRK00049
425104013489	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
425104013490	G1 box; other site
425104013491	GEF interaction site [polypeptide binding]; other site
425104013492	GTP/Mg2+ binding site [chemical binding]; other site
425104013493	Switch I region; other site
425104013494	G2 box; other site
425104013495	G3 box; other site
425104013496	Switch II region; other site
425104013497	G4 box; other site
425104013498	G5 box; other site
425104013499	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
425104013500	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
425104013501	Antibiotic Binding Site [chemical binding]; other site
425104013502	elongation factor G; Reviewed; Region: PRK00007
425104013503	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
425104013504	G1 box; other site
425104013505	putative GEF interaction site [polypeptide binding]; other site
425104013506	GTP/Mg2+ binding site [chemical binding]; other site
425104013507	Switch I region; other site
425104013508	G2 box; other site
425104013509	G3 box; other site
425104013510	Switch II region; other site
425104013511	G4 box; other site
425104013512	G5 box; other site
425104013513	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
425104013514	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
425104013515	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
425104013516	30S ribosomal protein S7; Validated; Region: PRK05302
425104013517	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
425104013518	S17 interaction site [polypeptide binding]; other site
425104013519	S8 interaction site; other site
425104013520	16S rRNA interaction site [nucleotide binding]; other site
425104013521	streptomycin interaction site [chemical binding]; other site
425104013522	23S rRNA interaction site [nucleotide binding]; other site
425104013523	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
425104013524	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
425104013525	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
425104013526	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
425104013527	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
425104013528	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
425104013529	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
425104013530	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
425104013531	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
425104013532	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
425104013533	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
425104013534	DNA binding site [nucleotide binding]
425104013535	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
425104013536	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
425104013537	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
425104013538	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
425104013539	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
425104013540	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
425104013541	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
425104013542	RPB3 interaction site [polypeptide binding]; other site
425104013543	RPB1 interaction site [polypeptide binding]; other site
425104013544	RPB11 interaction site [polypeptide binding]; other site
425104013545	RPB10 interaction site [polypeptide binding]; other site
425104013546	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
425104013547	core dimer interface [polypeptide binding]; other site
425104013548	peripheral dimer interface [polypeptide binding]; other site
425104013549	L10 interface [polypeptide binding]; other site
425104013550	L11 interface [polypeptide binding]; other site
425104013551	putative EF-Tu interaction site [polypeptide binding]; other site
425104013552	putative EF-G interaction site [polypeptide binding]; other site
425104013553	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
425104013554	23S rRNA interface [nucleotide binding]; other site
425104013555	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
425104013556	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
425104013557	mRNA/rRNA interface [nucleotide binding]; other site
425104013558	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
425104013559	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
425104013560	23S rRNA interface [nucleotide binding]; other site
425104013561	L7/L12 interface [polypeptide binding]; other site
425104013562	putative thiostrepton binding site; other site
425104013563	L25 interface [polypeptide binding]; other site
425104013564	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
425104013565	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
425104013566	putative homodimer interface [polypeptide binding]; other site
425104013567	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
425104013568	heterodimer interface [polypeptide binding]; other site
425104013569	homodimer interface [polypeptide binding]; other site
425104013570	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
425104013571	pantothenate kinase; Provisional; Region: PRK05439
425104013572	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
425104013573	ATP-binding site [chemical binding]; other site
425104013574	CoA-binding site [chemical binding]; other site
425104013575	Mg2+-binding site [ion binding]; other site
425104013576	Biotin operon repressor [Transcription]; Region: BirA; COG1654
425104013577	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
425104013578	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
425104013579	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
425104013580	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
425104013581	FAD binding domain; Region: FAD_binding_4; pfam01565
425104013582	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
425104013583	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
425104013584	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
425104013585	glutamate racemase; Provisional; Region: PRK00865
425104013586	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
425104013587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104013588	S-adenosylmethionine binding site [chemical binding]; other site
425104013589	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
425104013590	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
425104013591	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
425104013592	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
425104013593	Fatty acid desaturase; Region: FA_desaturase; pfam00487
425104013594	Di-iron ligands [ion binding]; other site
425104013595	selenophosphate synthetase; Provisional; Region: PRK00943
425104013596	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
425104013597	dimerization interface [polypeptide binding]; other site
425104013598	putative ATP binding site [chemical binding]; other site
425104013599	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
425104013600	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
425104013601	active site residue [active]
425104013602	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
425104013603	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
425104013604	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
425104013605	Coenzyme A binding pocket [chemical binding]; other site
425104013606	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
425104013607	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
425104013608	active site
425104013609	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
425104013610	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
425104013611	dimer interface [polypeptide binding]; other site
425104013612	ADP-ribose binding site [chemical binding]; other site
425104013613	active site
425104013614	nudix motif; other site
425104013615	metal binding site [ion binding]; metal-binding site
425104013616	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
425104013617	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
425104013618	active site
425104013619	motif I; other site
425104013620	motif II; other site
425104013621	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
425104013622	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
425104013623	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
425104013624	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
425104013625	GspL periplasmic domain; Region: GspL_C; pfam12693
425104013626	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
425104013627	type II secretion system protein J; Region: gspJ; TIGR01711
425104013628	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
425104013629	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
425104013630	type II secretion system protein I; Region: gspI; TIGR01707
425104013631	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
425104013632	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
425104013633	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
425104013634	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
425104013635	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
425104013636	type II secretion system protein F; Region: GspF; TIGR02120
425104013637	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
425104013638	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
425104013639	type II secretion system protein E; Region: type_II_gspE; TIGR02533
425104013640	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
425104013641	Walker A motif; other site
425104013642	ATP binding site [chemical binding]; other site
425104013643	Walker B motif; other site
425104013644	type II secretion system protein D; Region: type_II_gspD; TIGR02517
425104013645	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
425104013646	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
425104013647	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
425104013648	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
425104013649	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
425104013650	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
425104013651	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
425104013652	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
425104013653	RNA binding surface [nucleotide binding]; other site
425104013654	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
425104013655	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
425104013656	dimerization interface [polypeptide binding]; other site
425104013657	domain crossover interface; other site
425104013658	redox-dependent activation switch; other site
425104013659	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
425104013660	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
425104013661	active site
425104013662	substrate-binding site [chemical binding]; other site
425104013663	metal-binding site [ion binding]
425104013664	ATP binding site [chemical binding]; other site
425104013665	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
425104013666	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
425104013667	non-specific DNA binding site [nucleotide binding]; other site
425104013668	salt bridge; other site
425104013669	sequence-specific DNA binding site [nucleotide binding]; other site
425104013670	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241
425104013671	putative active site [active]
425104013672	Zn binding site [ion binding]; other site
425104013673	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
425104013674	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
425104013675	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
425104013676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
425104013677	Methyltransferase domain; Region: Methyltransf_31; pfam13847
425104013678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104013679	S-adenosylmethionine binding site [chemical binding]; other site
425104013680	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
425104013681	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
425104013682	GIY-YIG motif/motif A; other site
425104013683	putative active site [active]
425104013684	putative metal binding site [ion binding]; other site
425104013685	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
425104013686	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
425104013687	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
425104013688	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
425104013689	Nitrate and nitrite sensing; Region: NIT; pfam08376
425104013690	CHASE3 domain; Region: CHASE3; cl05000
425104013691	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
425104013692	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
425104013693	PAS domain; Region: PAS_9; pfam13426
425104013694	putative active site [active]
425104013695	heme pocket [chemical binding]; other site
425104013696	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104013697	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104013698	metal binding site [ion binding]; metal-binding site
425104013699	active site
425104013700	I-site; other site
425104013701	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
425104013702	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
425104013703	Ferritin-like domain; Region: Ferritin; pfam00210
425104013704	ferroxidase diiron center [ion binding]; other site
425104013705	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
425104013706	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
425104013707	HlyD family secretion protein; Region: HlyD_3; pfam13437
425104013708	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
425104013709	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
425104013710	dimer interface [polypeptide binding]; other site
425104013711	putative functional site; other site
425104013712	putative MPT binding site; other site
425104013713	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
425104013714	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
425104013715	ATP binding site [chemical binding]; other site
425104013716	substrate interface [chemical binding]; other site
425104013717	YecR-like lipoprotein; Region: YecR; pfam13992
425104013718	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
425104013719	Phosphotransferase enzyme family; Region: APH; pfam01636
425104013720	active site
425104013721	ATP binding site [chemical binding]; other site
425104013722	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
425104013723	substrate binding site [chemical binding]; other site
425104013724	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
425104013725	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
425104013726	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
425104013727	DNA binding residues [nucleotide binding]
425104013728	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
425104013729	hypothetical protein; Provisional; Region: PRK05409
425104013730	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
425104013731	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
425104013732	Protein of unknown function (DUF2986); Region: DUF2986; pfam11661
425104013733	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
425104013734	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
425104013735	membrane-bound complex binding site; other site
425104013736	hinge residues; other site
425104013737	Proteolipid membrane potential modulator; Region: Pmp3; cl00431
425104013738	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
425104013739	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
425104013740	active site
425104013741	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
425104013742	HAMP domain; Region: HAMP; pfam00672
425104013743	dimerization interface [polypeptide binding]; other site
425104013744	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
425104013745	dimer interface [polypeptide binding]; other site
425104013746	phosphorylation site [posttranslational modification]
425104013747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104013748	ATP binding site [chemical binding]; other site
425104013749	Mg2+ binding site [ion binding]; other site
425104013750	G-X-G motif; other site
425104013751	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
425104013752	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104013753	active site
425104013754	phosphorylation site [posttranslational modification]
425104013755	intermolecular recognition site; other site
425104013756	dimerization interface [polypeptide binding]; other site
425104013757	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104013758	DNA binding site [nucleotide binding]
425104013759	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
425104013760	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
425104013761	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104013762	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
425104013763	Walker A/P-loop; other site
425104013764	ATP binding site [chemical binding]; other site
425104013765	Q-loop/lid; other site
425104013766	ABC transporter signature motif; other site
425104013767	Walker B; other site
425104013768	D-loop; other site
425104013769	H-loop/switch region; other site
425104013770	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
425104013771	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
425104013772	dimer interface [polypeptide binding]; other site
425104013773	conserved gate region; other site
425104013774	putative PBP binding loops; other site
425104013775	ABC-ATPase subunit interface; other site
425104013776	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
425104013777	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
425104013778	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
425104013779	MoaE homodimer interface [polypeptide binding]; other site
425104013780	MoaD interaction [polypeptide binding]; other site
425104013781	active site residues [active]
425104013782	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
425104013783	MoaE interaction surface [polypeptide binding]; other site
425104013784	MoeB interaction surface [polypeptide binding]; other site
425104013785	thiocarboxylated glycine; other site
425104013786	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
425104013787	trimer interface [polypeptide binding]; other site
425104013788	dimer interface [polypeptide binding]; other site
425104013789	putative active site [active]
425104013790	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
425104013791	MPT binding site; other site
425104013792	trimer interface [polypeptide binding]; other site
425104013793	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
425104013794	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104013795	FeS/SAM binding site; other site
425104013796	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
425104013797	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
425104013798	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
425104013799	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
425104013800	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104013801	dimerization interface [polypeptide binding]; other site
425104013802	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104013803	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104013804	dimer interface [polypeptide binding]; other site
425104013805	putative CheW interface [polypeptide binding]; other site
425104013806	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
425104013807	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
425104013808	MOSC domain; Region: MOSC; pfam03473
425104013809	3-alpha domain; Region: 3-alpha; pfam03475
425104013810	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
425104013811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
425104013812	active site
425104013813	phosphorylation site [posttranslational modification]
425104013814	intermolecular recognition site; other site
425104013815	dimerization interface [polypeptide binding]; other site
425104013816	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
425104013817	DNA binding site [nucleotide binding]
425104013818	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
425104013819	dimer interface [polypeptide binding]; other site
425104013820	phosphorylation site [posttranslational modification]
425104013821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
425104013822	ATP binding site [chemical binding]; other site
425104013823	Mg2+ binding site [ion binding]; other site
425104013824	G-X-G motif; other site
425104013825	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
425104013826	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
425104013827	metal binding site [ion binding]; metal-binding site
425104013828	active site
425104013829	I-site; other site
425104013830	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
425104013831	substrate binding site [chemical binding]; other site
425104013832	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
425104013833	ATP binding site [chemical binding]; other site
425104013834	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
425104013835	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
425104013836	coproporphyrinogen III oxidase; Provisional; Region: PRK08629
425104013837	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
425104013838	FeS/SAM binding site; other site
425104013839	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
425104013840	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
425104013841	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
425104013842	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
425104013843	[4Fe-4S] binding site [ion binding]; other site
425104013844	molybdopterin cofactor binding site; other site
425104013845	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
425104013846	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
425104013847	molybdopterin cofactor binding site; other site
425104013848	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
425104013849	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
425104013850	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
425104013851	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
425104013852	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
425104013853	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
425104013854	[4Fe-4S] binding site [ion binding]; other site
425104013855	molybdopterin cofactor binding site; other site
425104013856	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
425104013857	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
425104013858	molybdopterin cofactor binding site; other site
425104013859	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
425104013860	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
425104013861	Ferredoxin [Energy production and conversion]; Region: COG1146
425104013862	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
425104013863	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
425104013864	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
425104013865	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
425104013866	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
425104013867	Helix-turn-helix domain; Region: HTH_17; pfam12728
425104013868	PBP superfamily domain; Region: PBP_like; pfam12727
425104013869	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
425104013870	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104013871	S-adenosylmethionine binding site [chemical binding]; other site
425104013872	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
425104013873	Chorismate lyase; Region: Chor_lyase; cl01230
425104013874	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
425104013875	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
425104013876	FOG: PKD repeat [General function prediction only]; Region: COG3291
425104013877	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
425104013878	alpha-glucosidase; Provisional; Region: PRK10137
425104013879	Trehalase; Region: Trehalase; cl17346
425104013880	putative antibiotic transporter; Provisional; Region: PRK10739
425104013881	NRDE protein; Region: NRDE; cl01315
425104013882	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
425104013883	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
425104013884	SnoaL-like domain; Region: SnoaL_3; pfam13474
425104013885	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
425104013886	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
425104013887	putative acyl-acceptor binding pocket; other site
425104013888	LysE type translocator; Region: LysE; cl00565
425104013889	Mechanosensitive ion channel; Region: MS_channel; pfam00924
425104013890	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
425104013891	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
425104013892	Protein of unknown function (DUF3157); Region: DUF3157; pfam11355
425104013893	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
425104013894	CoenzymeA binding site [chemical binding]; other site
425104013895	subunit interaction site [polypeptide binding]; other site
425104013896	PHB binding site; other site
425104013897	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
425104013898	active sites [active]
425104013899	tetramer interface [polypeptide binding]; other site
425104013900	urocanate hydratase; Provisional; Region: PRK05414
425104013901	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
425104013902	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
425104013903	DNA-binding site [nucleotide binding]; DNA binding site
425104013904	UTRA domain; Region: UTRA; pfam07702
425104013905	imidazolonepropionase; Validated; Region: PRK09356
425104013906	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
425104013907	active site
425104013908	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
425104013909	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
425104013910	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
425104013911	TPR motif; other site
425104013912	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
425104013913	Sel1-like repeats; Region: SEL1; smart00671
425104013914	Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229
425104013915	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
425104013916	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
425104013917	active site
425104013918	Predicted acetyltransferase [General function prediction only]; Region: COG2388
425104013919	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
425104013920	active site
425104013921	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
425104013922	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
425104013923	acyl-activating enzyme (AAE) consensus motif; other site
425104013924	putative AMP binding site [chemical binding]; other site
425104013925	putative active site [active]
425104013926	putative CoA binding site [chemical binding]; other site
425104013927	TAP-like protein; Region: Abhydrolase_4; pfam08386
425104013928	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
425104013929	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
425104013930	Walker A/P-loop; other site
425104013931	ATP binding site [chemical binding]; other site
425104013932	Q-loop/lid; other site
425104013933	ABC transporter signature motif; other site
425104013934	Walker B; other site
425104013935	D-loop; other site
425104013936	H-loop/switch region; other site
425104013937	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
425104013938	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
425104013939	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
425104013940	dimerization interface [polypeptide binding]; other site
425104013941	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104013942	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104013943	dimer interface [polypeptide binding]; other site
425104013944	putative CheW interface [polypeptide binding]; other site
425104013945	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
425104013946	MPT binding site; other site
425104013947	trimer interface [polypeptide binding]; other site
425104013948	NlpC/P60 family; Region: NLPC_P60; pfam00877
425104013949	HI0933-like protein; Region: HI0933_like; pfam03486
425104013950	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
425104013951	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
425104013952	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
425104013953	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
425104013954	SecA binding site; other site
425104013955	Preprotein binding site; other site
425104013956	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
425104013957	active site residue [active]
425104013958	phosphoglyceromutase; Provisional; Region: PRK05434
425104013959	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
425104013960	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
425104013961	Peptidase family M23; Region: Peptidase_M23; pfam01551
425104013962	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
425104013963	C-terminal peptidase (prc); Region: prc; TIGR00225
425104013964	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
425104013965	protein binding site [polypeptide binding]; other site
425104013966	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
425104013967	Catalytic dyad [active]
425104013968	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
425104013969	NodB motif; other site
425104013970	putative active site [active]
425104013971	putative catalytic site [active]
425104013972	Zn binding site [ion binding]; other site
425104013973	Transcriptional regulator; Region: Rrf2; cl17282
425104013974	Predicted transcriptional regulator [Transcription]; Region: COG1959
425104013975	Flagellin N-methylase; Region: FliB; cl00497
425104013976	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
425104013977	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
425104013978	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
425104013979	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
425104013980	substrate binding site [chemical binding]; other site
425104013981	oxyanion hole (OAH) forming residues; other site
425104013982	trimer interface [polypeptide binding]; other site
425104013983	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
425104013984	Winged helix-turn helix; Region: HTH_29; pfam13551
425104013985	Helix-turn-helix domain; Region: HTH_28; pfam13518
425104013986	Homeodomain-like domain; Region: HTH_32; pfam13565
425104013987	Integrase core domain; Region: rve; pfam00665
425104013988	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
425104013989	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
425104013990	glutaminase active site [active]
425104013991	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
425104013992	dimer interface [polypeptide binding]; other site
425104013993	active site
425104013994	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
425104013995	dimer interface [polypeptide binding]; other site
425104013996	active site
425104013997	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
425104013998	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
425104013999	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
425104014000	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
425104014001	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
425104014002	N-terminal plug; other site
425104014003	ligand-binding site [chemical binding]; other site
425104014004	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
425104014005	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
425104014006	Substrate binding site; other site
425104014007	Mg++ binding site; other site
425104014008	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
425104014009	active site
425104014010	substrate binding site [chemical binding]; other site
425104014011	CoA binding site [chemical binding]; other site
425104014012	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
425104014013	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
425104014014	gamma subunit interface [polypeptide binding]; other site
425104014015	epsilon subunit interface [polypeptide binding]; other site
425104014016	LBP interface [polypeptide binding]; other site
425104014017	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
425104014018	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
425104014019	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
425104014020	alpha subunit interaction interface [polypeptide binding]; other site
425104014021	Walker A motif; other site
425104014022	ATP binding site [chemical binding]; other site
425104014023	Walker B motif; other site
425104014024	inhibitor binding site; inhibition site
425104014025	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
425104014026	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
425104014027	core domain interface [polypeptide binding]; other site
425104014028	delta subunit interface [polypeptide binding]; other site
425104014029	epsilon subunit interface [polypeptide binding]; other site
425104014030	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
425104014031	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
425104014032	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
425104014033	beta subunit interaction interface [polypeptide binding]; other site
425104014034	Walker A motif; other site
425104014035	ATP binding site [chemical binding]; other site
425104014036	Walker B motif; other site
425104014037	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
425104014038	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
425104014039	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
425104014040	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
425104014041	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
425104014042	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
425104014043	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
425104014044	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
425104014045	ATP synthase I chain; Region: ATP_synt_I; cl09170
425104014046	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
425104014047	ParB-like nuclease domain; Region: ParBc; pfam02195
425104014048	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
425104014049	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
425104014050	P-loop; other site
425104014051	Magnesium ion binding site [ion binding]; other site
425104014052	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
425104014053	Magnesium ion binding site [ion binding]; other site
425104014054	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
425104014055	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104014056	S-adenosylmethionine binding site [chemical binding]; other site
425104014057	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
425104014058	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
425104014059	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
425104014060	FMN-binding protein MioC; Provisional; Region: PRK09004
425104014061	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
425104014062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
425104014063	S-adenosylmethionine binding site [chemical binding]; other site
425104014064	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
425104014065	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
425104014066	dimer interface [polypeptide binding]; other site
425104014067	putative CheW interface [polypeptide binding]; other site
425104014068	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
425104014069	Protein of unknown function (DUF1186); Region: DUF1186; pfam06685
425104014070	SEC-C motif; Region: SEC-C; pfam02810
425104014071	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
425104014072	PLD-like domain; Region: PLDc_2; pfam13091
425104014073	putative homodimer interface [polypeptide binding]; other site
425104014074	putative active site [active]
425104014075	catalytic site [active]
425104014076	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
425104014077	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104014078	ATP binding site [chemical binding]; other site
425104014079	putative Mg++ binding site [ion binding]; other site
425104014080	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104014081	nucleotide binding region [chemical binding]; other site
425104014082	ATP-binding site [chemical binding]; other site
425104014083	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
425104014084	Fic family protein [Function unknown]; Region: COG3177
425104014085	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
425104014086	Fic/DOC family; Region: Fic; pfam02661
425104014087	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
425104014088	putative DNA binding site [nucleotide binding]; other site
425104014089	putative Zn2+ binding site [ion binding]; other site
425104014090	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
425104014091	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
425104014092	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
425104014093	ATP binding site [chemical binding]; other site
425104014094	putative Mg++ binding site [ion binding]; other site
425104014095	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
425104014096	nucleotide binding region [chemical binding]; other site
425104014097	ATP-binding site [chemical binding]; other site
425104014098	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847