-- dump date 20140620_063159 -- class Genbank::misc_feature -- table misc_feature_note -- id note 693974000001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974000002 sequence-specific DNA binding site [nucleotide binding]; other site 693974000003 salt bridge; other site 693974000004 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 693974000005 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 693974000006 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693974000007 AAA domain; Region: AAA_23; pfam13476 693974000008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974000009 Walker A/P-loop; other site 693974000010 ATP binding site [chemical binding]; other site 693974000011 Growth-arrest specific micro-tubule binding; Region: GAS; pfam13851 693974000012 MarR family; Region: MarR_2; pfam12802 693974000013 ParB family; Region: ParB; pfam08775 693974000014 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 693974000015 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693974000016 P-loop; other site 693974000017 Magnesium ion binding site [ion binding]; other site 693974000018 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693974000019 Magnesium ion binding site [ion binding]; other site 693974000020 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 693974000021 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693974000022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693974000023 DNA binding residues [nucleotide binding] 693974000024 dimerization interface [polypeptide binding]; other site 693974000025 type IV conjugative transfer system pilin TraA; Region: TraA_TIGR; TIGR02758 693974000026 TraL protein; Region: TraL; pfam07178 693974000027 TraE protein; Region: TraE; pfam05309 693974000028 TraK protein; Region: TraK; pfam06586 693974000029 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 693974000030 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 693974000031 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 693974000032 type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747 693974000033 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 693974000034 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 693974000035 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 693974000036 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693974000037 Walker A motif; other site 693974000038 ATP binding site [chemical binding]; other site 693974000039 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677 693974000040 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 693974000041 TraU protein; Region: TraU; cl06067 693974000042 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 693974000043 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 693974000044 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 693974000045 F plasmid transfer operon protein; Region: TraF; pfam13728 693974000046 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693974000047 catalytic residues [active] 693974000048 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 693974000049 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 693974000050 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 693974000051 F sex factor protein N terminal; Region: TraD_N; pfam12615 693974000052 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693974000053 Walker A motif; other site 693974000054 ATP binding site [chemical binding]; other site 693974000055 Walker B motif; other site 693974000056 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693974000057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974000058 non-specific DNA binding site [nucleotide binding]; other site 693974000059 salt bridge; other site 693974000060 sequence-specific DNA binding site [nucleotide binding]; other site 693974000061 BstXI restriction endonuclease; Region: RE_BstXI; pfam09552 693974000062 DNA methylase; Region: N6_N4_Mtase; cl17433 693974000063 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 693974000064 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974000065 non-specific DNA binding site [nucleotide binding]; other site 693974000066 salt bridge; other site 693974000067 sequence-specific DNA binding site [nucleotide binding]; other site 693974000068 DNA methylase; Region: N6_N4_Mtase; pfam01555 693974000069 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 693974000070 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693974000071 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693974000072 active site 693974000073 catalytic residues [active] 693974000074 DNA binding site [nucleotide binding] 693974000075 Int/Topo IB signature motif; other site 693974000076 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693974000077 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 693974000078 active site 693974000079 DNA binding site [nucleotide binding] 693974000080 Int/Topo IB signature motif; other site 693974000081 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 693974000082 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 693974000083 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 693974000084 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693974000085 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 693974000086 ParB-like nuclease domain; Region: ParBc; pfam02195 693974000087 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 693974000088 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 693974000089 active site 693974000090 DNA binding site [nucleotide binding] 693974000091 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 693974000092 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 693974000093 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693974000094 Catalytic site [active] 693974000095 Abi-like protein; Region: Abi_2; pfam07751 693974000096 multiple promoter invertase; Provisional; Region: mpi; PRK13413 693974000097 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 693974000098 catalytic residues [active] 693974000099 catalytic nucleophile [active] 693974000100 DnaA N-terminal domain; Region: DnaA_N; pfam11638 693974000101 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 693974000102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974000103 Walker A motif; other site 693974000104 ATP binding site [chemical binding]; other site 693974000105 Walker B motif; other site 693974000106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 693974000107 arginine finger; other site 693974000108 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 693974000109 DnaA box-binding interface [nucleotide binding]; other site 693974000110 DNA polymerase III subunit beta; Validated; Region: PRK05643 693974000111 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 693974000112 putative DNA binding surface [nucleotide binding]; other site 693974000113 dimer interface [polypeptide binding]; other site 693974000114 beta-clamp/clamp loader binding surface; other site 693974000115 beta-clamp/translesion DNA polymerase binding surface; other site 693974000116 recombination protein F; Reviewed; Region: recF; PRK00064 693974000117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974000118 Walker A/P-loop; other site 693974000119 ATP binding site [chemical binding]; other site 693974000120 Q-loop/lid; other site 693974000121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974000122 ABC transporter signature motif; other site 693974000123 Walker B; other site 693974000124 D-loop; other site 693974000125 H-loop/switch region; other site 693974000126 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 693974000127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974000128 ATP binding site [chemical binding]; other site 693974000129 Mg2+ binding site [ion binding]; other site 693974000130 G-X-G motif; other site 693974000131 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 693974000132 anchoring element; other site 693974000133 dimer interface [polypeptide binding]; other site 693974000134 ATP binding site [chemical binding]; other site 693974000135 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 693974000136 active site 693974000137 putative metal-binding site [ion binding]; other site 693974000138 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693974000139 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 693974000140 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693974000141 putative C-terminal domain interface [polypeptide binding]; other site 693974000142 putative GSH binding site (G-site) [chemical binding]; other site 693974000143 putative dimer interface [polypeptide binding]; other site 693974000144 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 693974000145 putative N-terminal domain interface [polypeptide binding]; other site 693974000146 putative dimer interface [polypeptide binding]; other site 693974000147 putative substrate binding pocket (H-site) [chemical binding]; other site 693974000148 Cytochrome c; Region: Cytochrom_C; cl11414 693974000149 sulfite oxidase; Provisional; Region: PLN00177 693974000150 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 693974000151 Moco binding site; other site 693974000152 metal coordination site [ion binding]; other site 693974000153 dimerization interface [polypeptide binding]; other site 693974000154 Cytochrome c; Region: Cytochrom_C; cl11414 693974000155 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 693974000156 HDOD domain; Region: HDOD; pfam08668 693974000157 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693974000158 Zn2+ binding site [ion binding]; other site 693974000159 Mg2+ binding site [ion binding]; other site 693974000160 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 693974000161 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 693974000162 dimer interface [polypeptide binding]; other site 693974000163 motif 1; other site 693974000164 active site 693974000165 motif 2; other site 693974000166 motif 3; other site 693974000167 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 693974000168 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693974000169 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 693974000170 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693974000171 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 693974000172 Amidohydrolase; Region: Amidohydro_5; pfam13594 693974000173 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 693974000174 active site 693974000175 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693974000176 MOSC domain; Region: MOSC; pfam03473 693974000177 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 693974000178 CPxP motif; other site 693974000179 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 693974000180 heme-binding site [chemical binding]; other site 693974000181 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974000182 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974000183 metal binding site [ion binding]; metal-binding site 693974000184 active site 693974000185 I-site; other site 693974000186 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 693974000187 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693974000188 dimer interface [polypeptide binding]; other site 693974000189 active site 693974000190 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 693974000191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693974000192 substrate binding site [chemical binding]; other site 693974000193 oxyanion hole (OAH) forming residues; other site 693974000194 trimer interface [polypeptide binding]; other site 693974000195 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693974000196 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693974000197 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693974000198 proline dipeptidase; Provisional; Region: PRK13607 693974000199 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 693974000200 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 693974000201 active site 693974000202 hypothetical protein; Provisional; Region: PRK11568 693974000203 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 693974000204 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 693974000205 Cation transport protein; Region: TrkH; cl17365 693974000206 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693974000207 Flavodoxin domain; Region: Flavodoxin_5; cl17428 693974000208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693974000209 dimerization interface [polypeptide binding]; other site 693974000210 putative DNA binding site [nucleotide binding]; other site 693974000211 putative Zn2+ binding site [ion binding]; other site 693974000212 Flavodoxin domain; Region: Flavodoxin_5; cl17428 693974000213 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 693974000214 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693974000215 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 693974000216 TrkA-N domain; Region: TrkA_N; pfam02254 693974000217 TrkA-C domain; Region: TrkA_C; pfam02080 693974000218 TrkA-N domain; Region: TrkA_N; pfam02254 693974000219 TrkA-C domain; Region: TrkA_C; pfam02080 693974000220 16S rRNA methyltransferase B; Provisional; Region: PRK10901 693974000221 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 693974000222 putative RNA binding site [nucleotide binding]; other site 693974000223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974000224 S-adenosylmethionine binding site [chemical binding]; other site 693974000225 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 693974000226 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 693974000227 putative active site [active] 693974000228 substrate binding site [chemical binding]; other site 693974000229 putative cosubstrate binding site; other site 693974000230 catalytic site [active] 693974000231 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 693974000232 substrate binding site [chemical binding]; other site 693974000233 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693974000234 active site 693974000235 catalytic residues [active] 693974000236 metal binding site [ion binding]; metal-binding site 693974000237 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693974000238 DNA protecting protein DprA; Region: dprA; TIGR00732 693974000239 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 693974000240 Protein of unknown function (DUF494); Region: DUF494; pfam04361 693974000241 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693974000242 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693974000243 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693974000244 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 693974000245 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 693974000246 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 693974000247 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 693974000248 apolar tunnel; other site 693974000249 heme binding site [chemical binding]; other site 693974000250 dimerization interface [polypeptide binding]; other site 693974000251 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 693974000252 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693974000253 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 693974000254 shikimate binding site; other site 693974000255 NAD(P) binding site [chemical binding]; other site 693974000256 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 693974000257 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 693974000258 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 693974000259 trimer interface [polypeptide binding]; other site 693974000260 putative metal binding site [ion binding]; other site 693974000261 Flagellin N-methylase; Region: FliB; cl00497 693974000262 Transcriptional regulator; Region: Rrf2; cl17282 693974000263 Rrf2 family protein; Region: rrf2_super; TIGR00738 693974000264 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 693974000265 putative active site [active] 693974000266 putative catalytic site [active] 693974000267 NodB motif; other site 693974000268 Zn binding site [ion binding]; other site 693974000269 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 693974000270 C-terminal peptidase (prc); Region: prc; TIGR00225 693974000271 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 693974000272 protein binding site [polypeptide binding]; other site 693974000273 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 693974000274 Catalytic dyad [active] 693974000275 AmiB activator; Provisional; Region: PRK11637 693974000276 Peptidase family M23; Region: Peptidase_M23; pfam01551 693974000277 phosphoglyceromutase; Provisional; Region: PRK05434 693974000278 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 693974000279 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693974000280 active site residue [active] 693974000281 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 693974000282 SecA binding site; other site 693974000283 Preprotein binding site; other site 693974000284 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 693974000285 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693974000286 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 693974000287 HI0933-like protein; Region: HI0933_like; pfam03486 693974000288 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693974000289 Helix-turn-helix domain; Region: HTH_38; pfam13936 693974000290 Integrase core domain; Region: rve; pfam00665 693974000291 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693974000292 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 693974000293 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 693974000294 TrkA-N domain; Region: TrkA_N; pfam02254 693974000295 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693974000296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974000297 active site 693974000298 phosphorylation site [posttranslational modification] 693974000299 intermolecular recognition site; other site 693974000300 dimerization interface [polypeptide binding]; other site 693974000301 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974000302 DNA binding site [nucleotide binding] 693974000303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974000304 dimer interface [polypeptide binding]; other site 693974000305 phosphorylation site [posttranslational modification] 693974000306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974000307 ATP binding site [chemical binding]; other site 693974000308 Mg2+ binding site [ion binding]; other site 693974000309 G-X-G motif; other site 693974000310 Pirin-related protein [General function prediction only]; Region: COG1741 693974000311 Pirin; Region: Pirin; pfam02678 693974000312 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 693974000313 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 693974000314 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693974000315 GAF domain; Region: GAF_3; pfam13492 693974000316 Histidine kinase; Region: His_kinase; pfam06580 693974000317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974000318 ATP binding site [chemical binding]; other site 693974000319 Mg2+ binding site [ion binding]; other site 693974000320 G-X-G motif; other site 693974000321 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693974000322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974000323 active site 693974000324 phosphorylation site [posttranslational modification] 693974000325 intermolecular recognition site; other site 693974000326 dimerization interface [polypeptide binding]; other site 693974000327 LytTr DNA-binding domain; Region: LytTR; pfam04397 693974000328 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 693974000329 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693974000330 NlpC/P60 family; Region: NLPC_P60; pfam00877 693974000331 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693974000332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974000333 putative substrate translocation pore; other site 693974000334 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693974000335 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693974000336 DNA binding site [nucleotide binding] 693974000337 domain linker motif; other site 693974000338 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 693974000339 putative dimerization interface [polypeptide binding]; other site 693974000340 putative ligand binding site [chemical binding]; other site 693974000341 sucrose phosphorylase; Provisional; Region: PRK13840 693974000342 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 693974000343 active site 693974000344 homodimer interface [polypeptide binding]; other site 693974000345 catalytic site [active] 693974000346 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 693974000347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974000348 putative substrate translocation pore; other site 693974000349 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974000350 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974000351 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974000352 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693974000353 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 693974000354 putative substrate binding site [chemical binding]; other site 693974000355 putative ATP binding site [chemical binding]; other site 693974000356 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 693974000357 MPT binding site; other site 693974000358 trimer interface [polypeptide binding]; other site 693974000359 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 693974000360 MG2 domain; Region: A2M_N; pfam01835 693974000361 Alpha-2-macroglobulin family; Region: A2M; pfam00207 693974000362 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 693974000363 surface patch; other site 693974000364 thioester region; other site 693974000365 specificity defining residues; other site 693974000366 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 693974000367 Transglycosylase; Region: Transgly; pfam00912 693974000368 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693974000369 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 693974000370 Phage shock protein B; Region: PspB; cl05946 693974000371 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 693974000372 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 693974000373 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693974000374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974000375 Walker A/P-loop; other site 693974000376 ATP binding site [chemical binding]; other site 693974000377 Q-loop/lid; other site 693974000378 ABC transporter signature motif; other site 693974000379 Walker B; other site 693974000380 D-loop; other site 693974000381 H-loop/switch region; other site 693974000382 TAP-like protein; Region: Abhydrolase_4; pfam08386 693974000383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693974000384 Predicted transcriptional regulators [Transcription]; Region: COG1725 693974000385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693974000386 DNA-binding site [nucleotide binding]; DNA binding site 693974000387 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693974000388 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693974000389 Walker A/P-loop; other site 693974000390 ATP binding site [chemical binding]; other site 693974000391 Q-loop/lid; other site 693974000392 ABC transporter signature motif; other site 693974000393 Walker B; other site 693974000394 D-loop; other site 693974000395 H-loop/switch region; other site 693974000396 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 693974000397 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 693974000398 acyl-activating enzyme (AAE) consensus motif; other site 693974000399 putative AMP binding site [chemical binding]; other site 693974000400 putative active site [active] 693974000401 putative CoA binding site [chemical binding]; other site 693974000402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693974000403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693974000404 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693974000405 active site 693974000406 HPP family; Region: HPP; pfam04982 693974000407 Protein of unknown function (DUF3233); Region: DUF3233; pfam11557 693974000408 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693974000409 active site 693974000410 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693974000411 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 693974000412 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693974000413 DNA binding residues [nucleotide binding] 693974000414 putative dimer interface [polypeptide binding]; other site 693974000415 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 693974000416 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 693974000417 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 693974000418 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 693974000419 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 693974000420 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 693974000421 putative active site [active] 693974000422 catalytic site [active] 693974000423 putative metal binding site [ion binding]; other site 693974000424 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 693974000425 Lamin Tail Domain; Region: LTD; pfam00932 693974000426 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693974000427 Endonuclease I; Region: Endonuclease_1; pfam04231 693974000428 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693974000429 MarR family; Region: MarR_2; pfam12802 693974000430 MarR family; Region: MarR_2; cl17246 693974000431 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 693974000432 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 693974000433 FAD binding pocket [chemical binding]; other site 693974000434 FAD binding motif [chemical binding]; other site 693974000435 phosphate binding motif [ion binding]; other site 693974000436 NAD binding pocket [chemical binding]; other site 693974000437 imidazolonepropionase; Validated; Region: PRK09356 693974000438 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 693974000439 active site 693974000440 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 693974000441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693974000442 DNA-binding site [nucleotide binding]; DNA binding site 693974000443 UTRA domain; Region: UTRA; pfam07702 693974000444 urocanate hydratase; Provisional; Region: PRK05414 693974000445 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 693974000446 active sites [active] 693974000447 tetramer interface [polypeptide binding]; other site 693974000448 Biofilm formation and stress response factor; Region: BsmA; pfam10014 693974000449 transaminase; Validated; Region: PRK07324 693974000450 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693974000451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974000452 homodimer interface [polypeptide binding]; other site 693974000453 catalytic residue [active] 693974000454 AzlC protein; Region: AzlC; cl00570 693974000455 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 693974000456 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693974000457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974000458 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693974000459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974000460 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 693974000461 Peptidase family M48; Region: Peptidase_M48; cl12018 693974000462 Pilin (bacterial filament); Region: Pilin; pfam00114 693974000463 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 693974000464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693974000465 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 693974000466 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693974000467 Peptidase family M23; Region: Peptidase_M23; pfam01551 693974000468 Protein of unknown function (DUF3157); Region: DUF3157; pfam11355 693974000469 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 693974000470 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693974000471 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693974000472 LysE type translocator; Region: LysE; cl00565 693974000473 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693974000474 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 693974000475 putative acyl-acceptor binding pocket; other site 693974000476 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 693974000477 SnoaL-like domain; Region: SnoaL_3; pfam13474 693974000478 NRDE protein; Region: NRDE; cl01315 693974000479 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693974000480 DNA binding site [nucleotide binding] 693974000481 active site 693974000482 Int/Topo IB signature motif; other site 693974000483 catalytic residues [active] 693974000484 Putative phage integrase; Region: Phage_Integr_2; pfam13009 693974000485 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693974000486 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 693974000487 Fic family protein [Function unknown]; Region: COG3177 693974000488 Fic/DOC family; Region: Fic; pfam02661 693974000489 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 693974000490 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693974000491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974000492 non-specific DNA binding site [nucleotide binding]; other site 693974000493 salt bridge; other site 693974000494 sequence-specific DNA binding site [nucleotide binding]; other site 693974000495 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 693974000496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974000497 Walker A/P-loop; other site 693974000498 ATP binding site [chemical binding]; other site 693974000499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693974000500 Transposase; Region: HTH_Tnp_1; pfam01527 693974000501 putative transposase OrfB; Reviewed; Region: PHA02517 693974000502 HTH-like domain; Region: HTH_21; pfam13276 693974000503 Integrase core domain; Region: rve; pfam00665 693974000504 Integrase core domain; Region: rve_3; pfam13683 693974000505 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693974000506 active site 693974000507 catalytic residues [active] 693974000508 DNA binding site [nucleotide binding] 693974000509 Int/Topo IB signature motif; other site 693974000510 Response regulator receiver domain; Region: Response_reg; pfam00072 693974000511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974000512 active site 693974000513 phosphorylation site [posttranslational modification] 693974000514 intermolecular recognition site; other site 693974000515 dimerization interface [polypeptide binding]; other site 693974000516 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974000517 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974000518 metal binding site [ion binding]; metal-binding site 693974000519 active site 693974000520 I-site; other site 693974000521 CHASE domain; Region: CHASE; pfam03924 693974000522 PAS domain S-box; Region: sensory_box; TIGR00229 693974000523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974000524 putative active site [active] 693974000525 heme pocket [chemical binding]; other site 693974000526 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974000527 PAS domain; Region: PAS_9; pfam13426 693974000528 putative active site [active] 693974000529 heme pocket [chemical binding]; other site 693974000530 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693974000531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974000532 putative active site [active] 693974000533 heme pocket [chemical binding]; other site 693974000534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974000535 putative active site [active] 693974000536 heme pocket [chemical binding]; other site 693974000537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974000538 dimer interface [polypeptide binding]; other site 693974000539 phosphorylation site [posttranslational modification] 693974000540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974000541 ATP binding site [chemical binding]; other site 693974000542 Mg2+ binding site [ion binding]; other site 693974000543 G-X-G motif; other site 693974000544 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974000545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974000546 active site 693974000547 phosphorylation site [posttranslational modification] 693974000548 intermolecular recognition site; other site 693974000549 dimerization interface [polypeptide binding]; other site 693974000550 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974000551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974000552 active site 693974000553 phosphorylation site [posttranslational modification] 693974000554 intermolecular recognition site; other site 693974000555 dimerization interface [polypeptide binding]; other site 693974000556 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 693974000557 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693974000558 Helix-turn-helix domain; Region: HTH_38; pfam13936 693974000559 Integrase core domain; Region: rve; pfam00665 693974000560 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 693974000561 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693974000562 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 693974000563 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693974000564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974000565 active site 693974000566 phosphorylation site [posttranslational modification] 693974000567 intermolecular recognition site; other site 693974000568 dimerization interface [polypeptide binding]; other site 693974000569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974000570 Walker A motif; other site 693974000571 ATP binding site [chemical binding]; other site 693974000572 Walker B motif; other site 693974000573 arginine finger; other site 693974000574 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974000575 dimerization interface [polypeptide binding]; other site 693974000576 PAS domain S-box; Region: sensory_box; TIGR00229 693974000577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974000578 putative active site [active] 693974000579 heme pocket [chemical binding]; other site 693974000580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974000581 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693974000582 putative active site [active] 693974000583 heme pocket [chemical binding]; other site 693974000584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974000585 dimer interface [polypeptide binding]; other site 693974000586 phosphorylation site [posttranslational modification] 693974000587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974000588 ATP binding site [chemical binding]; other site 693974000589 Mg2+ binding site [ion binding]; other site 693974000590 G-X-G motif; other site 693974000591 Response regulator receiver domain; Region: Response_reg; pfam00072 693974000592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974000593 active site 693974000594 phosphorylation site [posttranslational modification] 693974000595 intermolecular recognition site; other site 693974000596 dimerization interface [polypeptide binding]; other site 693974000597 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 693974000598 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 693974000599 membrane-bound complex binding site; other site 693974000600 hinge residues; other site 693974000601 Response regulator receiver domain; Region: Response_reg; pfam00072 693974000602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974000603 active site 693974000604 phosphorylation site [posttranslational modification] 693974000605 intermolecular recognition site; other site 693974000606 dimerization interface [polypeptide binding]; other site 693974000607 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 693974000608 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 693974000609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 693974000610 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 693974000611 anti sigma factor interaction site; other site 693974000612 regulatory phosphorylation site [posttranslational modification]; other site 693974000613 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 693974000614 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 693974000615 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 693974000616 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 693974000617 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693974000618 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 693974000619 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693974000620 active site 693974000621 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 693974000622 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 693974000623 Bacterial sugar transferase; Region: Bac_transf; pfam02397 693974000624 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693974000625 active site 693974000626 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693974000627 putative trimer interface [polypeptide binding]; other site 693974000628 putative CoA binding site [chemical binding]; other site 693974000629 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693974000630 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 693974000631 active site 693974000632 nucleotide binding site [chemical binding]; other site 693974000633 HIGH motif; other site 693974000634 KMSKS motif; other site 693974000635 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 693974000636 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 693974000637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 693974000638 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 693974000639 FOG: PKD repeat [General function prediction only]; Region: COG3291 693974000640 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 693974000641 Chorismate lyase; Region: Chor_lyase; cl01230 693974000642 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 693974000643 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 693974000644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974000645 S-adenosylmethionine binding site [chemical binding]; other site 693974000646 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 693974000647 Domain of unknown function (DUF333); Region: DUF333; pfam03891 693974000648 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 693974000649 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 693974000650 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 693974000651 ATP binding site [chemical binding]; other site 693974000652 substrate interface [chemical binding]; other site 693974000653 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 693974000654 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 693974000655 dimer interface [polypeptide binding]; other site 693974000656 putative functional site; other site 693974000657 putative MPT binding site; other site 693974000658 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 693974000659 Ferritin-like domain; Region: Ferritin; pfam00210 693974000660 ferroxidase diiron center [ion binding]; other site 693974000661 Nitrate and nitrite sensing; Region: NIT; pfam08376 693974000662 Nitrate and nitrite sensing; Region: NIT; pfam08376 693974000663 HAMP domain; Region: HAMP; pfam00672 693974000664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974000665 PAS domain; Region: PAS_9; pfam13426 693974000666 putative active site [active] 693974000667 heme pocket [chemical binding]; other site 693974000668 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974000669 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974000670 metal binding site [ion binding]; metal-binding site 693974000671 active site 693974000672 I-site; other site 693974000673 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974000674 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 693974000675 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 693974000676 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 693974000677 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 693974000678 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693974000679 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 693974000680 GIY-YIG motif/motif A; other site 693974000681 putative active site [active] 693974000682 putative metal binding site [ion binding]; other site 693974000683 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 693974000684 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 693974000685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974000686 S-adenosylmethionine binding site [chemical binding]; other site 693974000687 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 693974000688 putative active site [active] 693974000689 Zn binding site [ion binding]; other site 693974000690 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693974000691 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693974000692 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693974000693 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 693974000694 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 693974000695 active site 693974000696 substrate-binding site [chemical binding]; other site 693974000697 metal-binding site [ion binding] 693974000698 ATP binding site [chemical binding]; other site 693974000699 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 693974000700 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 693974000701 dimerization interface [polypeptide binding]; other site 693974000702 domain crossover interface; other site 693974000703 redox-dependent activation switch; other site 693974000704 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693974000705 RNA binding surface [nucleotide binding]; other site 693974000706 putative type II secretion protein GspC; Provisional; Region: PRK09681 693974000707 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 693974000708 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 693974000709 type II secretion system protein D; Region: type_II_gspD; TIGR02517 693974000710 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693974000711 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693974000712 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693974000713 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693974000714 type II secretion system protein E; Region: type_II_gspE; TIGR02533 693974000715 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 693974000716 Walker A motif; other site 693974000717 ATP binding site [chemical binding]; other site 693974000718 Walker B motif; other site 693974000719 type II secretion system protein F; Region: GspF; TIGR02120 693974000720 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693974000721 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693974000722 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 693974000723 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 693974000724 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 693974000725 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 693974000726 Type II transport protein GspH; Region: GspH; pfam12019 693974000727 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 693974000728 type II secretion system protein I; Region: gspI; TIGR01707 693974000729 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 693974000730 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 693974000731 type II secretion system protein J; Region: gspJ; TIGR01711 693974000732 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 693974000733 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 693974000734 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 693974000735 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 693974000736 GspL periplasmic domain; Region: GspL_C; pfam12693 693974000737 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 693974000738 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 693974000739 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 693974000740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974000741 motif II; other site 693974000742 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 693974000743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974000744 S-adenosylmethionine binding site [chemical binding]; other site 693974000745 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 693974000746 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693974000747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974000748 Coenzyme A binding pocket [chemical binding]; other site 693974000749 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 693974000750 Phage Tail Collar Domain; Region: Collar; pfam07484 693974000751 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 693974000752 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 693974000753 Interdomain contacts; other site 693974000754 Cytokine receptor motif; other site 693974000755 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 693974000756 Interdomain contacts; other site 693974000757 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 693974000758 Cadherin repeat-like domain; Region: CA_like; cl15786 693974000759 Ca2+ binding site [ion binding]; other site 693974000760 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693974000761 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 693974000762 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693974000763 dimer interface [polypeptide binding]; other site 693974000764 ADP-ribose binding site [chemical binding]; other site 693974000765 active site 693974000766 nudix motif; other site 693974000767 metal binding site [ion binding]; metal-binding site 693974000768 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693974000769 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 693974000770 active site 693974000771 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693974000772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974000773 Coenzyme A binding pocket [chemical binding]; other site 693974000774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693974000775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974000776 WHG domain; Region: WHG; pfam13305 693974000777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974000778 putative substrate translocation pore; other site 693974000779 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693974000780 putative acyl-acceptor binding pocket; other site 693974000781 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 693974000782 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 693974000783 active site residue [active] 693974000784 selenophosphate synthetase; Provisional; Region: PRK00943 693974000785 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 693974000786 dimerization interface [polypeptide binding]; other site 693974000787 putative ATP binding site [chemical binding]; other site 693974000788 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 693974000789 Di-iron ligands [ion binding]; other site 693974000790 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 693974000791 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 693974000792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974000793 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 693974000794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974000795 S-adenosylmethionine binding site [chemical binding]; other site 693974000796 glutamate racemase; Provisional; Region: PRK00865 693974000797 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 693974000798 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 693974000799 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 693974000800 FAD binding domain; Region: FAD_binding_4; pfam01565 693974000801 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 693974000802 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 693974000803 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693974000804 dimerization interface [polypeptide binding]; other site 693974000805 putative Zn2+ binding site [ion binding]; other site 693974000806 putative DNA binding site [nucleotide binding]; other site 693974000807 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 693974000808 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 693974000809 pantothenate kinase; Provisional; Region: PRK05439 693974000810 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 693974000811 ATP-binding site [chemical binding]; other site 693974000812 CoA-binding site [chemical binding]; other site 693974000813 Mg2+-binding site [ion binding]; other site 693974000814 elongation factor Tu; Reviewed; Region: PRK00049 693974000815 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693974000816 G1 box; other site 693974000817 GEF interaction site [polypeptide binding]; other site 693974000818 GTP/Mg2+ binding site [chemical binding]; other site 693974000819 Switch I region; other site 693974000820 G2 box; other site 693974000821 G3 box; other site 693974000822 Switch II region; other site 693974000823 G4 box; other site 693974000824 G5 box; other site 693974000825 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693974000826 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693974000827 Antibiotic Binding Site [chemical binding]; other site 693974000828 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 693974000829 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 693974000830 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 693974000831 putative homodimer interface [polypeptide binding]; other site 693974000832 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 693974000833 heterodimer interface [polypeptide binding]; other site 693974000834 homodimer interface [polypeptide binding]; other site 693974000835 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 693974000836 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 693974000837 23S rRNA interface [nucleotide binding]; other site 693974000838 L7/L12 interface [polypeptide binding]; other site 693974000839 putative thiostrepton binding site; other site 693974000840 L25 interface [polypeptide binding]; other site 693974000841 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 693974000842 mRNA/rRNA interface [nucleotide binding]; other site 693974000843 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 693974000844 23S rRNA interface [nucleotide binding]; other site 693974000845 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 693974000846 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 693974000847 core dimer interface [polypeptide binding]; other site 693974000848 peripheral dimer interface [polypeptide binding]; other site 693974000849 L10 interface [polypeptide binding]; other site 693974000850 L11 interface [polypeptide binding]; other site 693974000851 putative EF-Tu interaction site [polypeptide binding]; other site 693974000852 putative EF-G interaction site [polypeptide binding]; other site 693974000853 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 693974000854 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 693974000855 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 693974000856 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 693974000857 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 693974000858 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 693974000859 RPB3 interaction site [polypeptide binding]; other site 693974000860 RPB1 interaction site [polypeptide binding]; other site 693974000861 RPB11 interaction site [polypeptide binding]; other site 693974000862 RPB10 interaction site [polypeptide binding]; other site 693974000863 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 693974000864 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 693974000865 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 693974000866 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 693974000867 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 693974000868 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 693974000869 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 693974000870 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 693974000871 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 693974000872 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 693974000873 DNA binding site [nucleotide binding] 693974000874 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 693974000875 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 693974000876 S17 interaction site [polypeptide binding]; other site 693974000877 S8 interaction site; other site 693974000878 16S rRNA interaction site [nucleotide binding]; other site 693974000879 streptomycin interaction site [chemical binding]; other site 693974000880 23S rRNA interaction site [nucleotide binding]; other site 693974000881 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 693974000882 30S ribosomal protein S7; Validated; Region: PRK05302 693974000883 elongation factor G; Reviewed; Region: PRK00007 693974000884 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 693974000885 G1 box; other site 693974000886 putative GEF interaction site [polypeptide binding]; other site 693974000887 GTP/Mg2+ binding site [chemical binding]; other site 693974000888 Switch I region; other site 693974000889 G2 box; other site 693974000890 G3 box; other site 693974000891 Switch II region; other site 693974000892 G4 box; other site 693974000893 G5 box; other site 693974000894 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 693974000895 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 693974000896 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 693974000897 elongation factor Tu; Reviewed; Region: PRK00049 693974000898 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693974000899 G1 box; other site 693974000900 GEF interaction site [polypeptide binding]; other site 693974000901 GTP/Mg2+ binding site [chemical binding]; other site 693974000902 Switch I region; other site 693974000903 G2 box; other site 693974000904 G3 box; other site 693974000905 Switch II region; other site 693974000906 G4 box; other site 693974000907 G5 box; other site 693974000908 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693974000909 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693974000910 Antibiotic Binding Site [chemical binding]; other site 693974000911 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 693974000912 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 693974000913 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 693974000914 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 693974000915 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 693974000916 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 693974000917 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 693974000918 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 693974000919 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 693974000920 putative translocon binding site; other site 693974000921 protein-rRNA interface [nucleotide binding]; other site 693974000922 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 693974000923 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 693974000924 G-X-X-G motif; other site 693974000925 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 693974000926 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 693974000927 23S rRNA interface [nucleotide binding]; other site 693974000928 5S rRNA interface [nucleotide binding]; other site 693974000929 putative antibiotic binding site [chemical binding]; other site 693974000930 L25 interface [polypeptide binding]; other site 693974000931 L27 interface [polypeptide binding]; other site 693974000932 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 693974000933 23S rRNA interface [nucleotide binding]; other site 693974000934 putative translocon interaction site; other site 693974000935 signal recognition particle (SRP54) interaction site; other site 693974000936 L23 interface [polypeptide binding]; other site 693974000937 trigger factor interaction site; other site 693974000938 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 693974000939 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 693974000940 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 693974000941 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 693974000942 RNA binding site [nucleotide binding]; other site 693974000943 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 693974000944 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 693974000945 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 693974000946 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 693974000947 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 693974000948 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 693974000949 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693974000950 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693974000951 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 693974000952 23S rRNA interface [nucleotide binding]; other site 693974000953 L21e interface [polypeptide binding]; other site 693974000954 5S rRNA interface [nucleotide binding]; other site 693974000955 L27 interface [polypeptide binding]; other site 693974000956 L5 interface [polypeptide binding]; other site 693974000957 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 693974000958 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 693974000959 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 693974000960 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 693974000961 23S rRNA binding site [nucleotide binding]; other site 693974000962 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 693974000963 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 693974000964 SecY translocase; Region: SecY; pfam00344 693974000965 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 693974000966 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 693974000967 30S ribosomal protein S13; Region: bact_S13; TIGR03631 693974000968 30S ribosomal protein S11; Validated; Region: PRK05309 693974000969 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 693974000970 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 693974000971 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693974000972 RNA binding surface [nucleotide binding]; other site 693974000973 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 693974000974 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 693974000975 alphaNTD homodimer interface [polypeptide binding]; other site 693974000976 alphaNTD - beta interaction site [polypeptide binding]; other site 693974000977 alphaNTD - beta' interaction site [polypeptide binding]; other site 693974000978 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 693974000979 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 693974000980 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693974000981 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693974000982 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 693974000983 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 693974000984 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 693974000985 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 693974000986 [4Fe-4S] binding site [ion binding]; other site 693974000987 molybdopterin cofactor binding site; other site 693974000988 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693974000989 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 693974000990 molybdopterin cofactor binding site; other site 693974000991 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 693974000992 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 693974000993 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 693974000994 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 693974000995 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 693974000996 [4Fe-4S] binding site [ion binding]; other site 693974000997 molybdopterin cofactor binding site; other site 693974000998 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 693974000999 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 693974001000 molybdopterin cofactor binding site; other site 693974001001 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 693974001002 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 693974001003 Ferredoxin [Energy production and conversion]; Region: COG1146 693974001004 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 693974001005 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693974001006 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 693974001007 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 693974001008 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 693974001009 Helix-turn-helix domain; Region: HTH_17; pfam12728 693974001010 PBP superfamily domain; Region: PBP_like; pfam12727 693974001011 putative acetyltransferase; Provisional; Region: PRK03624 693974001012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974001013 Coenzyme A binding pocket [chemical binding]; other site 693974001014 competence damage-inducible protein A; Provisional; Region: PRK00549 693974001015 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 693974001016 putative MPT binding site; other site 693974001017 Competence-damaged protein; Region: CinA; pfam02464 693974001018 Protein of unknown function (DUF1439); Region: DUF1439; pfam07273 693974001019 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 693974001020 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 693974001021 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 693974001022 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693974001023 acetylglutamate kinase; Provisional; Region: PRK00942 693974001024 nucleotide binding site [chemical binding]; other site 693974001025 substrate binding site [chemical binding]; other site 693974001026 ornithine carbamoyltransferase; Provisional; Region: PRK14805 693974001027 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693974001028 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693974001029 argininosuccinate synthase; Provisional; Region: PRK13820 693974001030 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 693974001031 ANP binding site [chemical binding]; other site 693974001032 Substrate Binding Site II [chemical binding]; other site 693974001033 Substrate Binding Site I [chemical binding]; other site 693974001034 argininosuccinate lyase; Provisional; Region: PRK04833 693974001035 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 693974001036 active sites [active] 693974001037 tetramer interface [polypeptide binding]; other site 693974001038 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 693974001039 Transglycosylase; Region: Transgly; pfam00912 693974001040 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693974001041 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693974001042 Competence protein A; Region: Competence_A; pfam11104 693974001043 nucleotide binding site [chemical binding]; other site 693974001044 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693974001045 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 693974001046 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 693974001047 Pilus assembly protein, PilO; Region: PilO; pfam04350 693974001048 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 693974001049 Pilus assembly protein, PilP; Region: PilP; pfam04351 693974001050 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 693974001051 Secretin and TonB N terminus short domain; Region: STN; smart00965 693974001052 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693974001053 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693974001054 shikimate kinase; Reviewed; Region: aroK; PRK00131 693974001055 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 693974001056 ADP binding site [chemical binding]; other site 693974001057 magnesium binding site [ion binding]; other site 693974001058 putative shikimate binding site; other site 693974001059 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 693974001060 active site 693974001061 dimer interface [polypeptide binding]; other site 693974001062 metal binding site [ion binding]; metal-binding site 693974001063 AAA ATPase domain; Region: AAA_16; pfam13191 693974001064 AAA domain; Region: AAA_22; pfam13401 693974001065 Walker A motif; other site 693974001066 ATP binding site [chemical binding]; other site 693974001067 Walker B motif; other site 693974001068 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 693974001069 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 693974001070 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 693974001071 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 693974001072 substrate binding site [chemical binding]; other site 693974001073 hexamer interface [polypeptide binding]; other site 693974001074 metal binding site [ion binding]; metal-binding site 693974001075 phosphoglycolate phosphatase; Provisional; Region: PRK13222 693974001076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 693974001077 motif I; other site 693974001078 active site 693974001079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974001080 motif II; other site 693974001081 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 693974001082 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 693974001083 active site 693974001084 HIGH motif; other site 693974001085 dimer interface [polypeptide binding]; other site 693974001086 KMSKS motif; other site 693974001087 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693974001088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974001089 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693974001090 dimerization interface [polypeptide binding]; other site 693974001091 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693974001092 EamA-like transporter family; Region: EamA; pfam00892 693974001093 outer membrane lipoprotein; Provisional; Region: PRK11023 693974001094 BON domain; Region: BON; pfam04972 693974001095 BON domain; Region: BON; pfam04972 693974001096 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 693974001097 dimer interface [polypeptide binding]; other site 693974001098 active site 693974001099 hypothetical protein; Reviewed; Region: PRK12497 693974001100 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 693974001101 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 693974001102 putative ligand binding site [chemical binding]; other site 693974001103 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 693974001104 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 693974001105 putative SAM binding site [chemical binding]; other site 693974001106 putative homodimer interface [polypeptide binding]; other site 693974001107 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 693974001108 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 693974001109 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 693974001110 Uncharacterized conserved protein [Function unknown]; Region: COG2966 693974001111 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 693974001112 Uncharacterized conserved protein [Function unknown]; Region: COG3610 693974001113 MAPEG family; Region: MAPEG; cl09190 693974001114 hypothetical protein; Provisional; Region: PRK01254 693974001115 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 693974001116 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 693974001117 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 693974001118 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693974001119 DNA binding site [nucleotide binding] 693974001120 domain linker motif; other site 693974001121 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 693974001122 putative ligand binding site [chemical binding]; other site 693974001123 putative dimerization interface [polypeptide binding]; other site 693974001124 low affinity gluconate transporter; Provisional; Region: PRK10472 693974001125 GntP family permease; Region: GntP_permease; pfam02447 693974001126 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 693974001127 Shikimate kinase; Region: SKI; pfam01202 693974001128 ATP-binding site [chemical binding]; other site 693974001129 Gluconate-6-phosphate binding site [chemical binding]; other site 693974001130 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693974001131 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693974001132 trimer interface [polypeptide binding]; other site 693974001133 eyelet of channel; other site 693974001134 putrescine transporter; Provisional; Region: potE; PRK10655 693974001135 ornithine decarboxylase; Provisional; Region: PRK13578 693974001136 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 693974001137 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 693974001138 homodimer interface [polypeptide binding]; other site 693974001139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974001140 catalytic residue [active] 693974001141 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 693974001142 Protein of unknown function (DUF2618); Region: DUF2618; pfam10940 693974001143 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 693974001144 substrate binding site [chemical binding]; other site 693974001145 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693974001146 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974001147 Uncharacterized conserved protein [Function unknown]; Region: COG3339 693974001148 Acyltransferase family; Region: Acyl_transf_3; pfam01757 693974001149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974001150 Coenzyme A binding pocket [chemical binding]; other site 693974001151 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 693974001152 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 693974001153 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693974001154 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 693974001155 DsbD alpha interface [polypeptide binding]; other site 693974001156 catalytic residues [active] 693974001157 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693974001158 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693974001159 catalytic residues [active] 693974001160 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693974001161 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693974001162 catalytic residues [active] 693974001163 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 693974001164 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693974001165 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693974001166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693974001167 DNA-binding site [nucleotide binding]; DNA binding site 693974001168 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693974001169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974001170 homodimer interface [polypeptide binding]; other site 693974001171 catalytic residue [active] 693974001172 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 693974001173 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 693974001174 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 693974001175 DsrE/DsrF-like family; Region: DrsE; cl00672 693974001176 Uncharacterized conserved protein [Function unknown]; Region: COG0397 693974001177 hypothetical protein; Validated; Region: PRK00029 693974001178 Protein of unknown function (DUF3630); Region: DUF3630; pfam12305 693974001179 serine/threonine protein kinase; Provisional; Region: PRK11768 693974001180 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 693974001181 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 693974001182 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 693974001183 catalytic residues [active] 693974001184 hinge region; other site 693974001185 alpha helical domain; other site 693974001186 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 693974001187 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 693974001188 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 693974001189 homotrimer interaction site [polypeptide binding]; other site 693974001190 putative active site [active] 693974001191 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073 693974001192 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 693974001193 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 693974001194 homodimer interface [polypeptide binding]; other site 693974001195 substrate-cofactor binding pocket; other site 693974001196 catalytic residue [active] 693974001197 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 693974001198 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 693974001199 PAS fold; Region: PAS_3; pfam08447 693974001200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974001201 PAS domain; Region: PAS_9; pfam13426 693974001202 putative active site [active] 693974001203 heme pocket [chemical binding]; other site 693974001204 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974001205 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974001206 metal binding site [ion binding]; metal-binding site 693974001207 active site 693974001208 I-site; other site 693974001209 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974001210 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 693974001211 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693974001212 tetramer interface [polypeptide binding]; other site 693974001213 active site 693974001214 Mg2+/Mn2+ binding site [ion binding]; other site 693974001215 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 693974001216 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 693974001217 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 693974001218 substrate binding site [chemical binding]; other site 693974001219 ligand binding site [chemical binding]; other site 693974001220 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 693974001221 substrate binding site [chemical binding]; other site 693974001222 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 693974001223 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 693974001224 dimer interface [polypeptide binding]; other site 693974001225 active site 693974001226 citrylCoA binding site [chemical binding]; other site 693974001227 oxalacetate/citrate binding site [chemical binding]; other site 693974001228 coenzyme A binding site [chemical binding]; other site 693974001229 catalytic triad [active] 693974001230 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 693974001231 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693974001232 tetramer interface [polypeptide binding]; other site 693974001233 active site 693974001234 Mg2+/Mn2+ binding site [ion binding]; other site 693974001235 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693974001236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693974001237 DNA-binding site [nucleotide binding]; DNA binding site 693974001238 FCD domain; Region: FCD; pfam07729 693974001239 Uncharacterized conserved protein [Function unknown]; Region: COG1683 693974001240 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693974001241 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 693974001242 putative acyl-acceptor binding pocket; other site 693974001243 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693974001244 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 693974001245 putative acyl-acceptor binding pocket; other site 693974001246 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 693974001247 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693974001248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974001249 Walker A motif; other site 693974001250 ATP binding site [chemical binding]; other site 693974001251 Walker B motif; other site 693974001252 arginine finger; other site 693974001253 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 693974001254 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 693974001255 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693974001256 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693974001257 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693974001258 GAF domain; Region: GAF; pfam01590 693974001259 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974001260 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974001261 metal binding site [ion binding]; metal-binding site 693974001262 active site 693974001263 I-site; other site 693974001264 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 693974001265 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974001266 substrate binding pocket [chemical binding]; other site 693974001267 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 693974001268 Domain of unknown function DUF21; Region: DUF21; pfam01595 693974001269 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693974001270 Transporter associated domain; Region: CorC_HlyC; smart01091 693974001271 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974001272 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 693974001273 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 693974001274 putative dimerization interface [polypeptide binding]; other site 693974001275 ketol-acid reductoisomerase; Validated; Region: PRK05225 693974001276 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 693974001277 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 693974001278 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 693974001279 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 693974001280 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693974001281 PYR/PP interface [polypeptide binding]; other site 693974001282 dimer interface [polypeptide binding]; other site 693974001283 TPP binding site [chemical binding]; other site 693974001284 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693974001285 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 693974001286 TPP-binding site [chemical binding]; other site 693974001287 dimer interface [polypeptide binding]; other site 693974001288 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 693974001289 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 693974001290 threonine dehydratase; Reviewed; Region: PRK09224 693974001291 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693974001292 tetramer interface [polypeptide binding]; other site 693974001293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974001294 catalytic residue [active] 693974001295 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 693974001296 putative Ile/Val binding site [chemical binding]; other site 693974001297 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 693974001298 putative Ile/Val binding site [chemical binding]; other site 693974001299 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 693974001300 homodimer interface [polypeptide binding]; other site 693974001301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974001302 catalytic residue [active] 693974001303 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 693974001304 Tim44-like domain; Region: Tim44; pfam04280 693974001305 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 693974001306 Na2 binding site [ion binding]; other site 693974001307 putative substrate binding site 1 [chemical binding]; other site 693974001308 Na binding site 1 [ion binding]; other site 693974001309 putative substrate binding site 2 [chemical binding]; other site 693974001310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693974001311 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693974001312 putative DNA binding site [nucleotide binding]; other site 693974001313 putative Zn2+ binding site [ion binding]; other site 693974001314 AsnC family; Region: AsnC_trans_reg; pfam01037 693974001315 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974001316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974001317 substrate binding pocket [chemical binding]; other site 693974001318 membrane-bound complex binding site; other site 693974001319 hinge residues; other site 693974001320 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693974001321 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 693974001322 active site 693974001323 inner membrane protein; Provisional; Region: PRK11715 693974001324 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 693974001325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 693974001326 Membrane fusogenic activity; Region: BMFP; pfam04380 693974001327 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 693974001328 Part of AAA domain; Region: AAA_19; pfam13245 693974001329 Family description; Region: UvrD_C_2; pfam13538 693974001330 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693974001331 GAF domain; Region: GAF; pfam01590 693974001332 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693974001333 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693974001334 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974001335 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974001336 metal binding site [ion binding]; metal-binding site 693974001337 active site 693974001338 I-site; other site 693974001339 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974001340 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974001341 dimerization interface [polypeptide binding]; other site 693974001342 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974001343 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974001344 metal binding site [ion binding]; metal-binding site 693974001345 active site 693974001346 I-site; other site 693974001347 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974001348 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 693974001349 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693974001350 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693974001351 ligand binding site [chemical binding]; other site 693974001352 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 693974001353 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 693974001354 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974001355 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974001356 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 693974001357 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 693974001358 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693974001359 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 693974001360 Walker A/P-loop; other site 693974001361 ATP binding site [chemical binding]; other site 693974001362 Q-loop/lid; other site 693974001363 ABC transporter signature motif; other site 693974001364 Walker B; other site 693974001365 D-loop; other site 693974001366 H-loop/switch region; other site 693974001367 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001368 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 693974001369 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001370 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001371 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001372 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001373 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001374 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 693974001375 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 693974001376 metal ion-dependent adhesion site (MIDAS); other site 693974001377 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 693974001378 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001379 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001380 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001381 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001382 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001383 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001384 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001385 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001386 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001387 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001388 VCBS repeat; Region: VCBS_repeat; TIGR01965 693974001389 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 693974001390 HemY protein N-terminus; Region: HemY_N; pfam07219 693974001391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693974001392 binding surface 693974001393 TPR motif; other site 693974001394 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 693974001395 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 693974001396 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 693974001397 active site 693974001398 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 693974001399 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 693974001400 domain interfaces; other site 693974001401 active site 693974001402 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 693974001403 adenylate cyclase; Provisional; Region: cyaA; PRK09450 693974001404 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 693974001405 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 693974001406 putative iron binding site [ion binding]; other site 693974001407 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 693974001408 diaminopimelate decarboxylase; Region: lysA; TIGR01048 693974001409 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 693974001410 active site 693974001411 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693974001412 substrate binding site [chemical binding]; other site 693974001413 catalytic residues [active] 693974001414 dimer interface [polypeptide binding]; other site 693974001415 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 693974001416 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693974001417 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693974001418 Protein of unknown function, DUF484; Region: DUF484; cl17449 693974001419 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 693974001420 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 693974001421 active site 693974001422 Int/Topo IB signature motif; other site 693974001423 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 693974001424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974001425 motif II; other site 693974001426 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 693974001427 Divergent AAA domain; Region: AAA_4; pfam04326 693974001428 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 693974001429 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 693974001430 Hemerythrin-like domain; Region: Hr-like; cd12108 693974001431 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 693974001432 FHIPEP family; Region: FHIPEP; pfam00771 693974001433 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 693974001434 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 693974001435 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 693974001436 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 693974001437 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 693974001438 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 693974001439 flagellar motor switch protein FliN; Region: fliN; TIGR02480 693974001440 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 693974001441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 693974001442 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 693974001443 active site 693974001444 dimerization interface [polypeptide binding]; other site 693974001445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974001446 Walker A motif; other site 693974001447 ATP binding site [chemical binding]; other site 693974001448 Walker B motif; other site 693974001449 arginine finger; other site 693974001450 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693974001451 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 693974001452 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 693974001453 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 693974001454 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 693974001455 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 693974001456 FliG C-terminal domain; Region: FliG_C; pfam01706 693974001457 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 693974001458 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 693974001459 Flagellar assembly protein FliH; Region: FliH; pfam02108 693974001460 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693974001461 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 693974001462 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693974001463 Walker A motif; other site 693974001464 ATP binding site [chemical binding]; other site 693974001465 Walker B motif; other site 693974001466 FlgN protein; Region: FlgN; pfam05130 693974001467 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 693974001468 SAF-like; Region: SAF_2; pfam13144 693974001469 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 693974001470 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 693974001471 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 693974001472 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 693974001473 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693974001474 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 693974001475 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 693974001476 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 693974001477 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693974001478 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 693974001479 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693974001480 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 693974001481 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693974001482 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 693974001483 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 693974001484 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693974001485 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693974001486 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 693974001487 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 693974001488 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 693974001489 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 693974001490 peptidoglycan hydrolase; Reviewed; Region: flgJ; PRK12708 693974001491 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 693974001492 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693974001493 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 693974001494 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693974001495 flagellin; Provisional; Region: PRK12802 693974001496 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693974001497 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693974001498 flagellin; Provisional; Region: PRK12802 693974001499 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693974001500 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693974001501 flagellin; Provisional; Region: PRK12802 693974001502 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693974001503 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693974001504 flagellin; Provisional; Region: PRK12802 693974001505 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693974001506 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693974001507 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 693974001508 flagellar capping protein; Reviewed; Region: fliD; PRK08032 693974001509 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 693974001510 Flagellar protein FliS; Region: FliS; cl00654 693974001511 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 693974001512 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 693974001513 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 693974001514 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693974001515 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693974001516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693974001517 DNA binding residues [nucleotide binding] 693974001518 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 693974001519 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 693974001520 hypothetical protein; Validated; Region: PRK06778 693974001521 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 693974001522 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 693974001523 ligand binding site [chemical binding]; other site 693974001524 PilZ domain; Region: PilZ; cl01260 693974001525 Part of AAA domain; Region: AAA_19; pfam13245 693974001526 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693974001527 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 693974001528 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 693974001529 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 693974001530 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693974001531 FMN binding site [chemical binding]; other site 693974001532 active site 693974001533 catalytic residues [active] 693974001534 substrate binding site [chemical binding]; other site 693974001535 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 693974001536 DNA methylase; Region: N6_N4_Mtase; cl17433 693974001537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974001538 S-adenosylmethionine binding site [chemical binding]; other site 693974001539 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13554 693974001540 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 693974001541 Iron-sulfur protein interface; other site 693974001542 proximal heme binding site [chemical binding]; other site 693974001543 distal heme binding site [chemical binding]; other site 693974001544 dimer interface [polypeptide binding]; other site 693974001545 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 693974001546 Iron-sulfur protein interface; other site 693974001547 proximal heme binding site [chemical binding]; other site 693974001548 distal heme binding site [chemical binding]; other site 693974001549 dimer interface [polypeptide binding]; other site 693974001550 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 693974001551 L-aspartate oxidase; Provisional; Region: PRK06175 693974001552 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693974001553 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 693974001554 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 693974001555 Uncharacterized conserved protein [Function unknown]; Region: COG1359 693974001556 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 693974001557 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 693974001558 putative NAD(P) binding site [chemical binding]; other site 693974001559 dimer interface [polypeptide binding]; other site 693974001560 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974001561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974001562 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974001563 putative effector binding pocket; other site 693974001564 dimerization interface [polypeptide binding]; other site 693974001565 transcription termination factor Rho; Provisional; Region: rho; PRK09376 693974001566 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 693974001567 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 693974001568 RNA binding site [nucleotide binding]; other site 693974001569 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 693974001570 multimer interface [polypeptide binding]; other site 693974001571 Walker A motif; other site 693974001572 ATP binding site [chemical binding]; other site 693974001573 Walker B motif; other site 693974001574 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693974001575 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693974001576 catalytic residues [active] 693974001577 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 693974001578 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693974001579 ATP binding site [chemical binding]; other site 693974001580 Mg++ binding site [ion binding]; other site 693974001581 motif III; other site 693974001582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974001583 nucleotide binding region [chemical binding]; other site 693974001584 ATP-binding site [chemical binding]; other site 693974001585 exopolyphosphatase; Region: exo_poly_only; TIGR03706 693974001586 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 693974001587 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693974001588 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693974001589 catalytic residues [active] 693974001590 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 693974001591 active site 693974001592 8-oxo-dGMP binding site [chemical binding]; other site 693974001593 nudix motif; other site 693974001594 metal binding site [ion binding]; metal-binding site 693974001595 Domain of unknown function (DUF329); Region: DUF329; pfam03884 693974001596 hypothetical protein; Provisional; Region: PRK05287 693974001597 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 693974001598 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 693974001599 CoA-binding site [chemical binding]; other site 693974001600 ATP-binding [chemical binding]; other site 693974001601 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 693974001602 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 693974001603 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 693974001604 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 693974001605 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693974001606 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693974001607 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 693974001608 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 693974001609 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 693974001610 Walker A motif; other site 693974001611 ATP binding site [chemical binding]; other site 693974001612 Walker B motif; other site 693974001613 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 693974001614 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 693974001615 dimerization interface [polypeptide binding]; other site 693974001616 active site 693974001617 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 693974001618 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 693974001619 amidase catalytic site [active] 693974001620 Zn binding residues [ion binding]; other site 693974001621 substrate binding site [chemical binding]; other site 693974001622 regulatory protein AmpE; Provisional; Region: PRK10987 693974001623 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 693974001624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693974001625 DNA-binding site [nucleotide binding]; DNA binding site 693974001626 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693974001627 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 693974001628 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 693974001629 dimer interface [polypeptide binding]; other site 693974001630 TPP-binding site [chemical binding]; other site 693974001631 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 693974001632 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693974001633 E3 interaction surface; other site 693974001634 lipoyl attachment site [posttranslational modification]; other site 693974001635 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693974001636 E3 interaction surface; other site 693974001637 lipoyl attachment site [posttranslational modification]; other site 693974001638 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693974001639 E3 interaction surface; other site 693974001640 lipoyl attachment site [posttranslational modification]; other site 693974001641 e3 binding domain; Region: E3_binding; pfam02817 693974001642 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693974001643 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 693974001644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693974001645 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693974001646 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693974001647 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 693974001648 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974001649 heme pocket [chemical binding]; other site 693974001650 putative active site [active] 693974001651 PAS fold; Region: PAS_3; pfam08447 693974001652 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974001653 PAS domain; Region: PAS_9; pfam13426 693974001654 putative active site [active] 693974001655 heme pocket [chemical binding]; other site 693974001656 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974001657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974001658 metal binding site [ion binding]; metal-binding site 693974001659 active site 693974001660 I-site; other site 693974001661 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974001662 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 693974001663 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 693974001664 active site 693974001665 nucleophile elbow; other site 693974001666 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693974001667 Surface antigen; Region: Bac_surface_Ag; pfam01103 693974001668 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 693974001669 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693974001670 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 693974001671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693974001672 Integrase core domain; Region: rve; pfam00665 693974001673 Integrase core domain; Region: rve_3; pfam13683 693974001674 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 693974001675 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 693974001676 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 693974001677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974001678 motif II; other site 693974001679 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 693974001680 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 693974001681 substrate binding site [chemical binding]; other site 693974001682 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 693974001683 substrate binding site [chemical binding]; other site 693974001684 ligand binding site [chemical binding]; other site 693974001685 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 693974001686 dimer interface [polypeptide binding]; other site 693974001687 allosteric magnesium binding site [ion binding]; other site 693974001688 active site 693974001689 aspartate-rich active site metal binding site; other site 693974001690 Schiff base residues; other site 693974001691 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 693974001692 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 693974001693 hypothetical protein; Region: PHA02277 693974001694 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974001695 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974001696 metal binding site [ion binding]; metal-binding site 693974001697 active site 693974001698 I-site; other site 693974001699 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693974001700 active site 693974001701 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 693974001702 sec-independent translocase; Provisional; Region: PRK01770 693974001703 sec-independent translocase; Provisional; Region: tatB; PRK00404 693974001704 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 693974001705 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 693974001706 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 693974001707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 693974001708 SCP-2 sterol transfer family; Region: SCP2; pfam02036 693974001709 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 693974001710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974001711 S-adenosylmethionine binding site [chemical binding]; other site 693974001712 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 693974001713 putative active site [active] 693974001714 putative metal binding site [ion binding]; other site 693974001715 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 693974001716 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 693974001717 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693974001718 active site 693974001719 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 693974001720 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693974001721 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 693974001722 nucleophilic elbow; other site 693974001723 catalytic triad; other site 693974001724 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693974001725 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693974001726 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 693974001727 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 693974001728 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693974001729 DHHA2 domain; Region: DHHA2; pfam02833 693974001730 Domain of unknown function (DUF386); Region: DUF386; cl01047 693974001731 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974001732 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974001733 N-terminal plug; other site 693974001734 ligand-binding site [chemical binding]; other site 693974001735 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 693974001736 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693974001737 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 693974001738 probable active site [active] 693974001739 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693974001740 metal binding site [ion binding]; metal-binding site 693974001741 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 693974001742 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 693974001743 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 693974001744 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 693974001745 NADP binding site [chemical binding]; other site 693974001746 active site 693974001747 putative substrate binding site [chemical binding]; other site 693974001748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693974001749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974001750 ATP binding site [chemical binding]; other site 693974001751 Mg2+ binding site [ion binding]; other site 693974001752 G-X-G motif; other site 693974001753 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 693974001754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974001755 active site 693974001756 phosphorylation site [posttranslational modification] 693974001757 intermolecular recognition site; other site 693974001758 dimerization interface [polypeptide binding]; other site 693974001759 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693974001760 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 693974001761 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 693974001762 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 693974001763 active site 693974001764 Zn binding site [ion binding]; other site 693974001765 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693974001766 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 693974001767 C factor cell-cell signaling protein; Provisional; Region: PRK09009 693974001768 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 693974001769 NADP binding site [chemical binding]; other site 693974001770 homodimer interface [polypeptide binding]; other site 693974001771 active site 693974001772 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 693974001773 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 693974001774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 693974001775 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 693974001776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974001777 Walker A motif; other site 693974001778 ATP binding site [chemical binding]; other site 693974001779 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 693974001780 Walker B motif; other site 693974001781 arginine finger; other site 693974001782 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693974001783 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 693974001784 active site 693974001785 HslU subunit interaction site [polypeptide binding]; other site 693974001786 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 693974001787 RibD C-terminal domain; Region: RibD_C; cl17279 693974001788 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 693974001789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974001790 active site 693974001791 phosphorylation site [posttranslational modification] 693974001792 intermolecular recognition site; other site 693974001793 dimerization interface [polypeptide binding]; other site 693974001794 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693974001795 DNA binding residues [nucleotide binding] 693974001796 dimerization interface [polypeptide binding]; other site 693974001797 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 693974001798 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 693974001799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974001800 ATP binding site [chemical binding]; other site 693974001801 Mg2+ binding site [ion binding]; other site 693974001802 G-X-G motif; other site 693974001803 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 693974001804 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974001805 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 693974001806 substrate binding pocket [chemical binding]; other site 693974001807 membrane-bound complex binding site; other site 693974001808 hinge residues; other site 693974001809 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693974001810 Sel1-like repeats; Region: SEL1; smart00671 693974001811 Sel1-like repeats; Region: SEL1; smart00671 693974001812 Sel1-like repeats; Region: SEL1; smart00671 693974001813 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693974001814 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693974001815 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 693974001816 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 693974001817 dimer interface [polypeptide binding]; other site 693974001818 active site 693974001819 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693974001820 catalytic residues [active] 693974001821 substrate binding site [chemical binding]; other site 693974001822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 693974001823 uridine phosphorylase; Provisional; Region: PRK11178 693974001824 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 693974001825 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 693974001826 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 693974001827 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 693974001828 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 693974001829 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 693974001830 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 693974001831 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 693974001832 Sporulation related domain; Region: SPOR; pfam05036 693974001833 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 693974001834 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 693974001835 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 693974001836 active site 693974001837 HIGH motif; other site 693974001838 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 693974001839 KMSK motif region; other site 693974001840 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 693974001841 tRNA binding surface [nucleotide binding]; other site 693974001842 anticodon binding site; other site 693974001843 primosome assembly protein PriA; Validated; Region: PRK05580 693974001844 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693974001845 ATP binding site [chemical binding]; other site 693974001846 putative Mg++ binding site [ion binding]; other site 693974001847 helicase superfamily c-terminal domain; Region: HELICc; smart00490 693974001848 FimV N-terminal domain; Region: FimV_core; TIGR03505 693974001849 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 693974001850 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 693974001851 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693974001852 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 693974001853 putative NAD(P) binding site [chemical binding]; other site 693974001854 regulatory protein CsrD; Provisional; Region: PRK11059 693974001855 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974001856 metal binding site [ion binding]; metal-binding site 693974001857 active site 693974001858 I-site; other site 693974001859 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974001860 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 693974001861 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 693974001862 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693974001863 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 693974001864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974001865 Walker A motif; other site 693974001866 ATP binding site [chemical binding]; other site 693974001867 Walker B motif; other site 693974001868 arginine finger; other site 693974001869 Tetratricopeptide repeat; Region: TPR_16; pfam13432 693974001870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974001871 TPR motif; other site 693974001872 binding surface 693974001873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974001874 binding surface 693974001875 TPR motif; other site 693974001876 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 693974001877 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 693974001878 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 693974001879 Walker A motif; other site 693974001880 ATP binding site [chemical binding]; other site 693974001881 Walker B motif; other site 693974001882 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 693974001883 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693974001884 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693974001885 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 693974001886 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 693974001887 VcfQ bacterial pilus biogenesis protein, lectin domain; Region: lectin_VcfQ; cd06900 693974001888 putative metal binding site [ion binding]; other site 693974001889 rod shape-determining protein MreB; Provisional; Region: PRK13927 693974001890 MreB and similar proteins; Region: MreB_like; cd10225 693974001891 nucleotide binding site [chemical binding]; other site 693974001892 Mg binding site [ion binding]; other site 693974001893 putative protofilament interaction site [polypeptide binding]; other site 693974001894 RodZ interaction site [polypeptide binding]; other site 693974001895 rod shape-determining protein MreC; Region: mreC; TIGR00219 693974001896 rod shape-determining protein MreC; Region: MreC; pfam04085 693974001897 rod shape-determining protein MreD; Region: MreD; cl01087 693974001898 Maf-like protein; Region: Maf; pfam02545 693974001899 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 693974001900 active site 693974001901 dimer interface [polypeptide binding]; other site 693974001902 ribonuclease G; Provisional; Region: PRK11712 693974001903 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 693974001904 homodimer interface [polypeptide binding]; other site 693974001905 oligonucleotide binding site [chemical binding]; other site 693974001906 TIGR02099 family protein; Region: TIGR02099 693974001907 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693974001908 nitrilase; Region: PLN02798 693974001909 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 693974001910 putative active site [active] 693974001911 catalytic triad [active] 693974001912 dimer interface [polypeptide binding]; other site 693974001913 protease TldD; Provisional; Region: tldD; PRK10735 693974001914 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 693974001915 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693974001916 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974001917 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974001918 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 693974001919 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 693974001920 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 693974001921 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 693974001922 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 693974001923 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 693974001924 amino acid transporter; Region: 2A0306; TIGR00909 693974001925 hypothetical protein; Provisional; Region: PRK05255 693974001926 peptidase PmbA; Provisional; Region: PRK11040 693974001927 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 693974001928 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974001929 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974001930 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974001931 substrate binding pocket [chemical binding]; other site 693974001932 membrane-bound complex binding site; other site 693974001933 hinge residues; other site 693974001934 Domain of unknown function; Region: DUF331; pfam03889 693974001935 fumarate hydratase; Reviewed; Region: fumC; PRK00485 693974001936 Class II fumarases; Region: Fumarase_classII; cd01362 693974001937 active site 693974001938 tetramer interface [polypeptide binding]; other site 693974001939 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 693974001940 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693974001941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974001942 FeS/SAM binding site; other site 693974001943 Uncharacterized conserved protein [Function unknown]; Region: COG2968 693974001944 oxidative stress defense protein; Provisional; Region: PRK11087 693974001945 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974001946 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693974001947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974001948 S-adenosylmethionine binding site [chemical binding]; other site 693974001949 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 693974001950 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 693974001951 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 693974001952 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693974001953 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693974001954 ligand binding site [chemical binding]; other site 693974001955 flexible hinge region; other site 693974001956 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 693974001957 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693974001958 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 693974001959 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 693974001960 putative active site [active] 693974001961 putative NTP binding site [chemical binding]; other site 693974001962 putative nucleic acid binding site [nucleotide binding]; other site 693974001963 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 693974001964 ATP binding site [chemical binding]; other site 693974001965 active site 693974001966 substrate binding site [chemical binding]; other site 693974001967 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 693974001968 putative hydrophobic ligand binding site [chemical binding]; other site 693974001969 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 693974001970 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 693974001971 thiosulfate reductase PhsA; Provisional; Region: PRK15488 693974001972 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 693974001973 putative [Fe4-S4] binding site [ion binding]; other site 693974001974 putative molybdopterin cofactor binding site [chemical binding]; other site 693974001975 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 693974001976 putative molybdopterin cofactor binding site; other site 693974001977 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 693974001978 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693974001979 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 693974001980 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 693974001981 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693974001982 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 693974001983 dimerization interface [polypeptide binding]; other site 693974001984 DNA binding site [nucleotide binding] 693974001985 corepressor binding sites; other site 693974001986 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 693974001987 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693974001988 homodimer interface [polypeptide binding]; other site 693974001989 substrate-cofactor binding pocket; other site 693974001990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974001991 catalytic residue [active] 693974001992 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 693974001993 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 693974001994 nucleotide binding site [chemical binding]; other site 693974001995 substrate binding site [chemical binding]; other site 693974001996 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 693974001997 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 693974001998 FAD binding site [chemical binding]; other site 693974001999 transcriptional regulator SlyA; Provisional; Region: PRK03573 693974002000 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 693974002001 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 693974002002 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974002003 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974002004 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 693974002005 Cytochrome c; Region: Cytochrom_C; cl11414 693974002006 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693974002007 Cytochrome c; Region: Cytochrom_C; pfam00034 693974002008 Cytochrome c [Energy production and conversion]; Region: COG3258 693974002009 Cytochrome c; Region: Cytochrom_C; pfam00034 693974002010 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 693974002011 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693974002012 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 693974002013 rarD protein; Region: rarD; TIGR00688 693974002014 EamA-like transporter family; Region: EamA; pfam00892 693974002015 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 693974002016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974002017 active site 693974002018 motif I; other site 693974002019 motif II; other site 693974002020 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 693974002021 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693974002022 ATP binding site [chemical binding]; other site 693974002023 Mg++ binding site [ion binding]; other site 693974002024 motif III; other site 693974002025 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974002026 nucleotide binding region [chemical binding]; other site 693974002027 ATP-binding site [chemical binding]; other site 693974002028 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 693974002029 putative RNA binding site [nucleotide binding]; other site 693974002030 M28 Zn-Peptidases; Region: M28_like_2; cd05662 693974002031 Peptidase family M28; Region: Peptidase_M28; pfam04389 693974002032 metal binding site [ion binding]; metal-binding site 693974002033 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 693974002034 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693974002035 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693974002036 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 693974002037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974002038 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693974002039 putative substrate translocation pore; other site 693974002040 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693974002041 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693974002042 dimer interface [polypeptide binding]; other site 693974002043 ssDNA binding site [nucleotide binding]; other site 693974002044 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693974002045 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693974002046 DNA binding site [nucleotide binding] 693974002047 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693974002048 active site 693974002049 catalytic residues [active] 693974002050 DNA binding site [nucleotide binding] 693974002051 Int/Topo IB signature motif; other site 693974002052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 693974002053 chromosome segregation protein; Provisional; Region: PRK03918 693974002054 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 693974002055 AAA domain; Region: AAA_30; pfam13604 693974002056 Family description; Region: UvrD_C_2; pfam13538 693974002057 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 693974002058 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693974002059 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 693974002060 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 693974002061 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 693974002062 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 693974002063 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693974002064 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 693974002065 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 693974002066 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 693974002067 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 693974002068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693974002069 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 693974002070 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 693974002071 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 693974002072 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 693974002073 Family description; Region: VCBS; pfam13517 693974002074 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 693974002075 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 693974002076 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 693974002077 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 693974002078 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 693974002079 Archaebacterial flagellin; Region: Arch_flagellin; cl00732 693974002080 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 693974002081 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693974002082 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693974002083 catalytic residues [active] 693974002084 catalytic nucleophile [active] 693974002085 Presynaptic Site I dimer interface [polypeptide binding]; other site 693974002086 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693974002087 Synaptic Flat tetramer interface [polypeptide binding]; other site 693974002088 Synaptic Site I dimer interface [polypeptide binding]; other site 693974002089 DNA binding site [nucleotide binding] 693974002090 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 693974002091 DNA-binding interface [nucleotide binding]; DNA binding site 693974002092 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 693974002093 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 693974002094 DNA binding site [nucleotide binding] 693974002095 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 693974002096 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 693974002097 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 693974002098 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 693974002099 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 693974002100 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693974002101 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 693974002102 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 693974002103 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 693974002104 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 693974002105 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693974002106 Transposase; Region: HTH_Tnp_1; cl17663 693974002107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693974002108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974002109 Walker A/P-loop; other site 693974002110 ATP binding site [chemical binding]; other site 693974002111 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693974002112 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693974002113 eyelet of channel; other site 693974002114 trimer interface [polypeptide binding]; other site 693974002115 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 693974002116 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 693974002117 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 693974002118 L-aspartate oxidase; Provisional; Region: PRK06175 693974002119 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693974002120 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13554 693974002121 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 693974002122 Iron-sulfur protein interface; other site 693974002123 proximal heme binding site [chemical binding]; other site 693974002124 distal heme binding site [chemical binding]; other site 693974002125 dimer interface [polypeptide binding]; other site 693974002126 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 693974002127 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 693974002128 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 693974002129 Aspartase; Region: Aspartase; cd01357 693974002130 active sites [active] 693974002131 tetramer interface [polypeptide binding]; other site 693974002132 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 693974002133 active site 693974002134 homodimer interface [polypeptide binding]; other site 693974002135 homotetramer interface [polypeptide binding]; other site 693974002136 Chorismate mutase type II; Region: CM_2; cl00693 693974002137 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 693974002138 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974002139 substrate binding pocket [chemical binding]; other site 693974002140 membrane-bound complex binding site; other site 693974002141 hinge residues; other site 693974002142 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693974002143 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693974002144 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693974002145 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693974002146 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693974002147 Part of AAA domain; Region: AAA_19; pfam13245 693974002148 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 693974002149 AAA domain; Region: AAA_12; pfam13087 693974002150 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 693974002151 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 693974002152 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 693974002153 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693974002154 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693974002155 catalytic residue [active] 693974002156 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693974002157 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693974002158 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 693974002159 Leucine rich repeat; Region: LRR_8; pfam13855 693974002160 Substrate binding site [chemical binding]; other site 693974002161 Leucine rich repeat; Region: LRR_8; pfam13855 693974002162 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 693974002163 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 693974002164 active site 693974002165 ATP binding site [chemical binding]; other site 693974002166 substrate binding site [chemical binding]; other site 693974002167 activation loop (A-loop); other site 693974002168 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693974002169 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974002170 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693974002171 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693974002172 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693974002173 Sel1-like repeats; Region: SEL1; smart00671 693974002174 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 693974002175 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 693974002176 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693974002177 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693974002178 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693974002179 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 693974002180 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 693974002181 NAD(P) binding site [chemical binding]; other site 693974002182 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 693974002183 active site 693974002184 catalytic residues [active] 693974002185 galactokinase; Provisional; Region: PRK05101 693974002186 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 693974002187 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693974002188 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 693974002189 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 693974002190 TrkA-N domain; Region: TrkA_N; pfam02254 693974002191 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 693974002192 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 693974002193 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693974002194 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 693974002195 DsbD alpha interface [polypeptide binding]; other site 693974002196 catalytic residues [active] 693974002197 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 693974002198 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 693974002199 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693974002200 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693974002201 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974002202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974002203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974002204 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974002205 putative effector binding pocket; other site 693974002206 dimerization interface [polypeptide binding]; other site 693974002207 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693974002208 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693974002209 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 693974002210 oligomerisation interface [polypeptide binding]; other site 693974002211 mobile loop; other site 693974002212 roof hairpin; other site 693974002213 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 693974002214 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693974002215 ring oligomerisation interface [polypeptide binding]; other site 693974002216 ATP/Mg binding site [chemical binding]; other site 693974002217 stacking interactions; other site 693974002218 hinge regions; other site 693974002219 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693974002220 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974002221 non-specific DNA binding site [nucleotide binding]; other site 693974002222 salt bridge; other site 693974002223 sequence-specific DNA binding site [nucleotide binding]; other site 693974002224 HipA N-terminal domain; Region: Couple_hipA; pfam13657 693974002225 HipA-like N-terminal domain; Region: HipA_N; pfam07805 693974002226 HipA-like C-terminal domain; Region: HipA_C; pfam07804 693974002227 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 693974002228 Protein of unknown function (DUF2999); Region: DUF2999; pfam11212 693974002229 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 693974002230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974002231 ABC transporter signature motif; other site 693974002232 Walker B; other site 693974002233 D-loop; other site 693974002234 H-loop/switch region; other site 693974002235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974002236 Walker A/P-loop; other site 693974002237 ATP binding site [chemical binding]; other site 693974002238 Q-loop/lid; other site 693974002239 ABC transporter signature motif; other site 693974002240 Walker B; other site 693974002241 D-loop; other site 693974002242 H-loop/switch region; other site 693974002243 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 693974002244 Zn binding site [ion binding]; other site 693974002245 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693974002246 DNA binding residues [nucleotide binding] 693974002247 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 693974002248 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693974002249 catalytic residues [active] 693974002250 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693974002251 DNA-binding site [nucleotide binding]; DNA binding site 693974002252 RNA-binding motif; other site 693974002253 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 693974002254 Predicted transcriptional regulators [Transcription]; Region: COG1695 693974002255 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 693974002256 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693974002257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974002258 putative active site [active] 693974002259 heme pocket [chemical binding]; other site 693974002260 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974002261 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974002262 metal binding site [ion binding]; metal-binding site 693974002263 active site 693974002264 I-site; other site 693974002265 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 693974002266 dimer interface [polypeptide binding]; other site 693974002267 Alkaline phosphatase homologues; Region: alkPPc; smart00098 693974002268 active site 693974002269 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 693974002270 dimer interface [polypeptide binding]; other site 693974002271 Alkaline phosphatase homologues; Region: alkPPc; smart00098 693974002272 active site 693974002273 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693974002274 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974002275 Helix-turn-helix domain; Region: HTH_18; pfam12833 693974002276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974002277 LysE type translocator; Region: LysE; cl00565 693974002278 TIR domain; Region: TIR_2; pfam13676 693974002279 GAF domain; Region: GAF; pfam01590 693974002280 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974002281 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974002282 metal binding site [ion binding]; metal-binding site 693974002283 active site 693974002284 I-site; other site 693974002285 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974002286 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 693974002287 active site 693974002288 lipoprotein; Provisional; Region: PRK11443 693974002289 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 693974002290 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 693974002291 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 693974002292 ATP binding site [chemical binding]; other site 693974002293 Transposase; Region: HTH_Tnp_1; cl17663 693974002294 putative outer membrane lipoprotein; Provisional; Region: PRK10510 693974002295 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693974002296 ligand binding site [chemical binding]; other site 693974002297 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 693974002298 MgtE intracellular N domain; Region: MgtE_N; smart00924 693974002299 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 693974002300 Divalent cation transporter; Region: MgtE; pfam01769 693974002301 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693974002302 dimerization domain swap beta strand [polypeptide binding]; other site 693974002303 regulatory protein interface [polypeptide binding]; other site 693974002304 active site 693974002305 regulatory phosphorylation site [posttranslational modification]; other site 693974002306 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 693974002307 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102 693974002308 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693974002309 active site 693974002310 phosphorylation site [posttranslational modification] 693974002311 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693974002312 30S subunit binding site; other site 693974002313 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 693974002314 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 693974002315 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 693974002316 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 693974002317 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 693974002318 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 693974002319 Walker A/P-loop; other site 693974002320 ATP binding site [chemical binding]; other site 693974002321 Q-loop/lid; other site 693974002322 ABC transporter signature motif; other site 693974002323 Walker B; other site 693974002324 D-loop; other site 693974002325 H-loop/switch region; other site 693974002326 OstA-like protein; Region: OstA; cl00844 693974002327 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 693974002328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 693974002329 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 693974002330 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 693974002331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974002332 active site 693974002333 motif I; other site 693974002334 motif II; other site 693974002335 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 693974002336 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 693974002337 putative active site [active] 693974002338 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 693974002339 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 693974002340 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 693974002341 Walker A/P-loop; other site 693974002342 ATP binding site [chemical binding]; other site 693974002343 Q-loop/lid; other site 693974002344 ABC transporter signature motif; other site 693974002345 Walker B; other site 693974002346 D-loop; other site 693974002347 H-loop/switch region; other site 693974002348 conserved hypothetical integral membrane protein; Region: TIGR00056 693974002349 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 693974002350 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 693974002351 mce related protein; Region: MCE; pfam02470 693974002352 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 693974002353 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 693974002354 anti sigma factor interaction site; other site 693974002355 regulatory phosphorylation site [posttranslational modification]; other site 693974002356 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 693974002357 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 693974002358 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 693974002359 hinge; other site 693974002360 active site 693974002361 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 693974002362 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693974002363 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693974002364 protein binding site [polypeptide binding]; other site 693974002365 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 693974002366 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693974002367 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693974002368 protein binding site [polypeptide binding]; other site 693974002369 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693974002370 Predicted ATPase [General function prediction only]; Region: COG1485 693974002371 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 693974002372 23S rRNA interface [nucleotide binding]; other site 693974002373 L3 interface [polypeptide binding]; other site 693974002374 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 693974002375 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 693974002376 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 693974002377 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 693974002378 GDP-binding site [chemical binding]; other site 693974002379 ACT binding site; other site 693974002380 IMP binding site; other site 693974002381 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693974002382 Sel1 repeat; Region: Sel1; cl02723 693974002383 exoribonuclease R; Provisional; Region: PRK11642 693974002384 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 693974002385 RNB domain; Region: RNB; pfam00773 693974002386 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 693974002387 RNA binding site [nucleotide binding]; other site 693974002388 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 693974002389 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 693974002390 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693974002391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974002392 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693974002393 putative substrate translocation pore; other site 693974002394 Protein of unknown function, DUF481; Region: DUF481; pfam04338 693974002395 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 693974002396 primosomal replication protein N; Provisional; Region: PRK02801 693974002397 generic binding surface II; other site 693974002398 generic binding surface I; other site 693974002399 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 693974002400 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 693974002401 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 693974002402 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 693974002403 Peptidase S46; Region: Peptidase_S46; pfam10459 693974002404 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693974002405 replicative DNA helicase; Provisional; Region: PRK08006 693974002406 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 693974002407 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 693974002408 Walker A motif; other site 693974002409 ATP binding site [chemical binding]; other site 693974002410 Walker B motif; other site 693974002411 DNA binding loops [nucleotide binding] 693974002412 alanine racemase; Reviewed; Region: alr; PRK00053 693974002413 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 693974002414 active site 693974002415 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693974002416 substrate binding site [chemical binding]; other site 693974002417 catalytic residues [active] 693974002418 dimer interface [polypeptide binding]; other site 693974002419 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 693974002420 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 693974002421 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 693974002422 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974002423 N-terminal plug; other site 693974002424 ligand-binding site [chemical binding]; other site 693974002425 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 693974002426 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 693974002427 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693974002428 FMN binding site [chemical binding]; other site 693974002429 active site 693974002430 catalytic residues [active] 693974002431 substrate binding site [chemical binding]; other site 693974002432 PspC domain; Region: PspC; pfam04024 693974002433 enoyl-CoA hydratase; Provisional; Region: PRK06688 693974002434 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693974002435 substrate binding site [chemical binding]; other site 693974002436 oxyanion hole (OAH) forming residues; other site 693974002437 trimer interface [polypeptide binding]; other site 693974002438 Protein of unknown function (DUF461); Region: DUF461; pfam04314 693974002439 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 693974002440 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 693974002441 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 693974002442 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 693974002443 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693974002444 dimer interface [polypeptide binding]; other site 693974002445 ADP-ribose binding site [chemical binding]; other site 693974002446 active site 693974002447 nudix motif; other site 693974002448 metal binding site [ion binding]; metal-binding site 693974002449 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 693974002450 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 693974002451 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693974002452 active site 693974002453 metal binding site [ion binding]; metal-binding site 693974002454 hexamer interface [polypeptide binding]; other site 693974002455 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 693974002456 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693974002457 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 693974002458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974002459 ATP binding site [chemical binding]; other site 693974002460 Mg2+ binding site [ion binding]; other site 693974002461 G-X-G motif; other site 693974002462 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 693974002463 anchoring element; other site 693974002464 dimer interface [polypeptide binding]; other site 693974002465 ATP binding site [chemical binding]; other site 693974002466 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 693974002467 active site 693974002468 metal binding site [ion binding]; metal-binding site 693974002469 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693974002470 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 693974002471 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 693974002472 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693974002473 CAP-like domain; other site 693974002474 active site 693974002475 primary dimer interface [polypeptide binding]; other site 693974002476 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693974002477 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693974002478 eyelet of channel; other site 693974002479 trimer interface [polypeptide binding]; other site 693974002480 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693974002481 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693974002482 eyelet of channel; other site 693974002483 trimer interface [polypeptide binding]; other site 693974002484 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 693974002485 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 693974002486 putative ATP binding site [chemical binding]; other site 693974002487 putative substrate interface [chemical binding]; other site 693974002488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 693974002489 dimer interface [polypeptide binding]; other site 693974002490 phosphorylation site [posttranslational modification] 693974002491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974002492 ATP binding site [chemical binding]; other site 693974002493 Mg2+ binding site [ion binding]; other site 693974002494 G-X-G motif; other site 693974002495 Superinfection exclusion protein B; Region: SieB; pfam14163 693974002496 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 693974002497 HAMP domain; Region: HAMP; pfam00672 693974002498 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974002499 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974002500 dimer interface [polypeptide binding]; other site 693974002501 putative CheW interface [polypeptide binding]; other site 693974002502 Hemerythrin; Region: Hemerythrin; cd12107 693974002503 Fe binding site [ion binding]; other site 693974002504 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 693974002505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974002506 Walker A/P-loop; other site 693974002507 ATP binding site [chemical binding]; other site 693974002508 Q-loop/lid; other site 693974002509 ABC transporter signature motif; other site 693974002510 Walker B; other site 693974002511 D-loop; other site 693974002512 H-loop/switch region; other site 693974002513 TOBE domain; Region: TOBE; cl01440 693974002514 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693974002515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974002516 dimer interface [polypeptide binding]; other site 693974002517 conserved gate region; other site 693974002518 putative PBP binding loops; other site 693974002519 ABC-ATPase subunit interface; other site 693974002520 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 693974002521 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693974002522 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 693974002523 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 693974002524 TOBE domain; Region: TOBE; cl01440 693974002525 TOBE domain; Region: TOBE; cl01440 693974002526 macrolide transporter subunit MacA; Provisional; Region: PRK11578 693974002527 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974002528 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974002529 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 693974002530 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693974002531 Walker A/P-loop; other site 693974002532 ATP binding site [chemical binding]; other site 693974002533 Q-loop/lid; other site 693974002534 ABC transporter signature motif; other site 693974002535 Walker B; other site 693974002536 D-loop; other site 693974002537 H-loop/switch region; other site 693974002538 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693974002539 FtsX-like permease family; Region: FtsX; pfam02687 693974002540 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 693974002541 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 693974002542 Peptidase family M50; Region: Peptidase_M50; pfam02163 693974002543 active site 693974002544 putative substrate binding region [chemical binding]; other site 693974002545 protein structure with unknown function; Region: DUF4144; pfam13642 693974002546 Protein of unknown function (DUF342); Region: DUF342; pfam03961 693974002547 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 693974002548 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 693974002549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974002550 S-adenosylmethionine binding site [chemical binding]; other site 693974002551 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 693974002552 dimer interface [polypeptide binding]; other site 693974002553 Alkaline phosphatase homologues; Region: alkPPc; smart00098 693974002554 active site 693974002555 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 693974002556 glutathione synthetase; Provisional; Region: PRK05246 693974002557 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 693974002558 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 693974002559 RNA methyltransferase, RsmE family; Region: TIGR00046 693974002560 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 693974002561 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 693974002562 hypothetical protein; Provisional; Region: PRK04860 693974002563 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 693974002564 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 693974002565 putative substrate binding pocket [chemical binding]; other site 693974002566 AC domain interface; other site 693974002567 catalytic triad [active] 693974002568 AB domain interface; other site 693974002569 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 693974002570 LysR family transcriptional regulator; Provisional; Region: PRK14997 693974002571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974002572 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 693974002573 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974002574 putative effector binding pocket; other site 693974002575 dimerization interface [polypeptide binding]; other site 693974002576 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 693974002577 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 693974002578 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693974002579 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693974002580 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693974002581 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693974002582 carboxyltransferase (CT) interaction site; other site 693974002583 biotinylation site [posttranslational modification]; other site 693974002584 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 693974002585 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974002586 substrate binding pocket [chemical binding]; other site 693974002587 membrane-bound complex binding site; other site 693974002588 hinge residues; other site 693974002589 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974002590 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974002591 metal binding site [ion binding]; metal-binding site 693974002592 active site 693974002593 I-site; other site 693974002594 elongation factor G; Reviewed; Region: PRK00007 693974002595 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 693974002596 G1 box; other site 693974002597 putative GEF interaction site [polypeptide binding]; other site 693974002598 GTP/Mg2+ binding site [chemical binding]; other site 693974002599 Switch I region; other site 693974002600 G2 box; other site 693974002601 G3 box; other site 693974002602 Switch II region; other site 693974002603 G4 box; other site 693974002604 G5 box; other site 693974002605 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 693974002606 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 693974002607 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 693974002608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974002609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974002610 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 693974002611 putative dimerization interface [polypeptide binding]; other site 693974002612 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 693974002613 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 693974002614 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 693974002615 [4Fe-4S] binding site [ion binding]; other site 693974002616 molybdopterin cofactor binding site; other site 693974002617 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 693974002618 molybdopterin cofactor binding site; other site 693974002619 NapD protein; Region: NapD; pfam03927 693974002620 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 693974002621 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693974002622 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 693974002623 FtsX-like permease family; Region: FtsX; pfam02687 693974002624 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693974002625 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693974002626 Walker A/P-loop; other site 693974002627 ATP binding site [chemical binding]; other site 693974002628 Q-loop/lid; other site 693974002629 ABC transporter signature motif; other site 693974002630 Walker B; other site 693974002631 D-loop; other site 693974002632 H-loop/switch region; other site 693974002633 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693974002634 amino acid carrier protein; Region: agcS; TIGR00835 693974002635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693974002636 PAS domain; Region: PAS_9; pfam13426 693974002637 PAS domain S-box; Region: sensory_box; TIGR00229 693974002638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974002639 putative active site [active] 693974002640 heme pocket [chemical binding]; other site 693974002641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974002642 PAS fold; Region: PAS_3; pfam08447 693974002643 putative active site [active] 693974002644 heme pocket [chemical binding]; other site 693974002645 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693974002646 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974002647 putative active site [active] 693974002648 heme pocket [chemical binding]; other site 693974002649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974002650 putative active site [active] 693974002651 heme pocket [chemical binding]; other site 693974002652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974002653 dimer interface [polypeptide binding]; other site 693974002654 phosphorylation site [posttranslational modification] 693974002655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974002656 ATP binding site [chemical binding]; other site 693974002657 Mg2+ binding site [ion binding]; other site 693974002658 G-X-G motif; other site 693974002659 Response regulator receiver domain; Region: Response_reg; pfam00072 693974002660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974002661 active site 693974002662 phosphorylation site [posttranslational modification] 693974002663 intermolecular recognition site; other site 693974002664 dimerization interface [polypeptide binding]; other site 693974002665 Response regulator receiver domain; Region: Response_reg; pfam00072 693974002666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974002667 active site 693974002668 phosphorylation site [posttranslational modification] 693974002669 intermolecular recognition site; other site 693974002670 dimerization interface [polypeptide binding]; other site 693974002671 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 693974002672 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 693974002673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974002674 active site 693974002675 phosphorylation site [posttranslational modification] 693974002676 intermolecular recognition site; other site 693974002677 dimerization interface [polypeptide binding]; other site 693974002678 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693974002679 Zn2+ binding site [ion binding]; other site 693974002680 Mg2+ binding site [ion binding]; other site 693974002681 putative global regulator; Reviewed; Region: PRK09559 693974002682 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 693974002683 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 693974002684 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 693974002685 ligand binding site [chemical binding]; other site 693974002686 NAD binding site [chemical binding]; other site 693974002687 tetramer interface [polypeptide binding]; other site 693974002688 catalytic site [active] 693974002689 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 693974002690 L-serine binding site [chemical binding]; other site 693974002691 ACT domain interface; other site 693974002692 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 693974002693 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693974002694 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693974002695 DNA binding residues [nucleotide binding] 693974002696 dimerization interface [polypeptide binding]; other site 693974002697 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 693974002698 major curlin subunit; Provisional; Region: csgA; PRK10051 693974002699 Curlin associated repeat; Region: Curlin_rpt; pfam07012 693974002700 Curlin associated repeat; Region: Curlin_rpt; pfam07012 693974002701 Curlin associated repeat; Region: Curlin_rpt; pfam07012 693974002702 Curlin associated repeat; Region: Curlin_rpt; pfam07012 693974002703 Curlin associated repeat; Region: Curlin_rpt; pfam07012 693974002704 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 693974002705 Pantoate-beta-alanine ligase; Region: PanC; cd00560 693974002706 pantoate--beta-alanine ligase; Region: panC; TIGR00018 693974002707 active site 693974002708 ATP-binding site [chemical binding]; other site 693974002709 pantoate-binding site; other site 693974002710 HXXH motif; other site 693974002711 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 693974002712 oligomerization interface [polypeptide binding]; other site 693974002713 active site 693974002714 metal binding site [ion binding]; metal-binding site 693974002715 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 693974002716 catalytic center binding site [active] 693974002717 ATP binding site [chemical binding]; other site 693974002718 poly(A) polymerase; Region: pcnB; TIGR01942 693974002719 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 693974002720 active site 693974002721 NTP binding site [chemical binding]; other site 693974002722 metal binding triad [ion binding]; metal-binding site 693974002723 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 693974002724 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 693974002725 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 693974002726 active site 693974002727 nucleotide binding site [chemical binding]; other site 693974002728 HIGH motif; other site 693974002729 KMSKS motif; other site 693974002730 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 693974002731 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 693974002732 aminopeptidase B; Provisional; Region: PRK05015 693974002733 Peptidase; Region: DUF3663; pfam12404 693974002734 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693974002735 interface (dimer of trimers) [polypeptide binding]; other site 693974002736 Substrate-binding/catalytic site; other site 693974002737 Zn-binding sites [ion binding]; other site 693974002738 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693974002739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974002740 Coenzyme A binding pocket [chemical binding]; other site 693974002741 phosphoribulokinase; Provisional; Region: PRK15453 693974002742 active site 693974002743 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 693974002744 putative hydrolase; Provisional; Region: PRK10985 693974002745 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 693974002746 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693974002747 Transcriptional activator [Transcription]; Region: ChrR; COG3806 693974002748 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 693974002749 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 693974002750 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 693974002751 classical (c) SDRs; Region: SDR_c; cd05233 693974002752 NAD(P) binding site [chemical binding]; other site 693974002753 active site 693974002754 Predicted transcriptional regulators [Transcription]; Region: COG1733 693974002755 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 693974002756 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693974002757 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 693974002758 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 693974002759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974002760 Walker A/P-loop; other site 693974002761 ATP binding site [chemical binding]; other site 693974002762 Q-loop/lid; other site 693974002763 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974002764 ABC transporter; Region: ABC_tran_2; pfam12848 693974002765 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974002766 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 693974002767 short chain dehydrogenase; Provisional; Region: PRK07478 693974002768 classical (c) SDRs; Region: SDR_c; cd05233 693974002769 NAD(P) binding site [chemical binding]; other site 693974002770 active site 693974002771 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693974002772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974002773 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 693974002774 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693974002775 DNA binding site [nucleotide binding] 693974002776 active site 693974002777 Pirin-related protein [General function prediction only]; Region: COG1741 693974002778 Pirin; Region: Pirin; pfam02678 693974002779 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 693974002780 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 693974002781 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693974002782 ATP binding site [chemical binding]; other site 693974002783 Mg++ binding site [ion binding]; other site 693974002784 motif III; other site 693974002785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974002786 nucleotide binding region [chemical binding]; other site 693974002787 ATP-binding site [chemical binding]; other site 693974002788 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 693974002789 putative RNA binding site [nucleotide binding]; other site 693974002790 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 693974002791 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693974002792 ATP binding site [chemical binding]; other site 693974002793 Mg++ binding site [ion binding]; other site 693974002794 motif III; other site 693974002795 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974002796 nucleotide binding region [chemical binding]; other site 693974002797 ATP-binding site [chemical binding]; other site 693974002798 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 693974002799 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 693974002800 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693974002801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974002802 Walker A/P-loop; other site 693974002803 ATP binding site [chemical binding]; other site 693974002804 Q-loop/lid; other site 693974002805 ABC transporter signature motif; other site 693974002806 Walker B; other site 693974002807 D-loop; other site 693974002808 H-loop/switch region; other site 693974002809 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 693974002810 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693974002811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974002812 Walker A/P-loop; other site 693974002813 ATP binding site [chemical binding]; other site 693974002814 Q-loop/lid; other site 693974002815 ABC transporter signature motif; other site 693974002816 Walker B; other site 693974002817 D-loop; other site 693974002818 H-loop/switch region; other site 693974002819 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 693974002820 putative active site [active] 693974002821 putative metal binding residues [ion binding]; other site 693974002822 signature motif; other site 693974002823 putative triphosphate binding site [ion binding]; other site 693974002824 dimer interface [polypeptide binding]; other site 693974002825 Helix-turn-helix domain; Region: HTH_17; pfam12728 693974002826 Protein of unknown function, DUF599; Region: DUF599; pfam04654 693974002827 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 693974002828 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 693974002829 Proline dehydrogenase; Region: Pro_dh; pfam01619 693974002830 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 693974002831 Glutamate binding site [chemical binding]; other site 693974002832 NAD binding site [chemical binding]; other site 693974002833 catalytic residues [active] 693974002834 Bacterial SH3 domain homologues; Region: SH3b; smart00287 693974002835 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 693974002836 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693974002837 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693974002838 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 693974002839 Uncharacterized conserved protein [Function unknown]; Region: COG3025 693974002840 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 693974002841 putative active site [active] 693974002842 putative metal binding residues [ion binding]; other site 693974002843 signature motif; other site 693974002844 putative triphosphate binding site [ion binding]; other site 693974002845 Ion channel; Region: Ion_trans_2; pfam07885 693974002846 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 693974002847 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 693974002848 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 693974002849 spermidine synthase; Provisional; Region: PRK03612 693974002850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693974002851 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 693974002852 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693974002853 metal binding triad; other site 693974002854 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 693974002855 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693974002856 metal binding triad; other site 693974002857 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693974002858 GAF domain; Region: GAF; pfam01590 693974002859 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974002860 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974002861 metal binding site [ion binding]; metal-binding site 693974002862 active site 693974002863 I-site; other site 693974002864 Domain of unknown function (DUF897); Region: DUF897; pfam05982 693974002865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974002866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974002867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693974002868 dimerization interface [polypeptide binding]; other site 693974002869 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 693974002870 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974002871 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974002872 dimerization interface [polypeptide binding]; other site 693974002873 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974002874 dimer interface [polypeptide binding]; other site 693974002875 putative CheW interface [polypeptide binding]; other site 693974002876 Predicted ATPase [General function prediction only]; Region: COG1485 693974002877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974002878 Walker A/P-loop; other site 693974002879 ATP binding site [chemical binding]; other site 693974002880 ABC transporter signature motif; other site 693974002881 Walker B; other site 693974002882 D-loop; other site 693974002883 H-loop/switch region; other site 693974002884 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 693974002885 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 693974002886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 693974002887 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 693974002888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 693974002889 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 693974002890 PAS domain; Region: PAS; smart00091 693974002891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974002892 ATP binding site [chemical binding]; other site 693974002893 Mg2+ binding site [ion binding]; other site 693974002894 G-X-G motif; other site 693974002895 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 693974002896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974002897 active site 693974002898 phosphorylation site [posttranslational modification] 693974002899 intermolecular recognition site; other site 693974002900 dimerization interface [polypeptide binding]; other site 693974002901 Transcriptional regulator; Region: CitT; pfam12431 693974002902 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693974002903 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693974002904 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693974002905 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693974002906 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 693974002907 putative active site [active] 693974002908 Zn binding site [ion binding]; other site 693974002909 L,D-transpeptidase; Provisional; Region: PRK10260 693974002910 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693974002911 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693974002912 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 693974002913 potassium/proton antiporter; Reviewed; Region: PRK05326 693974002914 TrkA-C domain; Region: TrkA_C; pfam02080 693974002915 Transporter associated domain; Region: CorC_HlyC; smart01091 693974002916 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 693974002917 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693974002918 putative acyl-acceptor binding pocket; other site 693974002919 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 693974002920 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 693974002921 putative ribose interaction site [chemical binding]; other site 693974002922 putative ADP binding site [chemical binding]; other site 693974002923 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 693974002924 active site 693974002925 HIGH motif; other site 693974002926 nucleotide binding site [chemical binding]; other site 693974002927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974002928 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 693974002929 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 693974002930 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 693974002931 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 693974002932 ligand binding site [chemical binding]; other site 693974002933 homodimer interface [polypeptide binding]; other site 693974002934 NAD(P) binding site [chemical binding]; other site 693974002935 trimer interface B [polypeptide binding]; other site 693974002936 trimer interface A [polypeptide binding]; other site 693974002937 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 693974002938 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 693974002939 Flavodoxin; Region: Flavodoxin_1; pfam00258 693974002940 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 693974002941 FAD binding pocket [chemical binding]; other site 693974002942 FAD binding motif [chemical binding]; other site 693974002943 catalytic residues [active] 693974002944 NAD binding pocket [chemical binding]; other site 693974002945 phosphate binding motif [ion binding]; other site 693974002946 beta-alpha-beta structure motif; other site 693974002947 sulfite reductase subunit beta; Provisional; Region: PRK13504 693974002948 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693974002949 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 693974002950 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 693974002951 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693974002952 Active Sites [active] 693974002953 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 693974002954 Transglycosylase; Region: Transgly; cl17702 693974002955 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 693974002956 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 693974002957 Active site serine [active] 693974002958 Phage endonuclease I; Region: Phage_endo_I; cl11622 693974002959 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 693974002960 dimerization interface [polypeptide binding]; other site 693974002961 substrate binding site [chemical binding]; other site 693974002962 active site 693974002963 calcium binding site [ion binding]; other site 693974002964 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 693974002965 active site 693974002966 SAM binding site [chemical binding]; other site 693974002967 homodimer interface [polypeptide binding]; other site 693974002968 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 693974002969 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 693974002970 Active Sites [active] 693974002971 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 693974002972 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 693974002973 CysD dimerization site [polypeptide binding]; other site 693974002974 G1 box; other site 693974002975 putative GEF interaction site [polypeptide binding]; other site 693974002976 GTP/Mg2+ binding site [chemical binding]; other site 693974002977 Switch I region; other site 693974002978 G2 box; other site 693974002979 G3 box; other site 693974002980 Switch II region; other site 693974002981 G4 box; other site 693974002982 G5 box; other site 693974002983 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 693974002984 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 693974002985 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693974002986 TrkA-C domain; Region: TrkA_C; pfam02080 693974002987 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693974002988 TrkA-C domain; Region: TrkA_C; pfam02080 693974002989 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693974002990 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 693974002991 ligand-binding site [chemical binding]; other site 693974002992 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693974002993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974002994 ATP binding site [chemical binding]; other site 693974002995 Mg2+ binding site [ion binding]; other site 693974002996 G-X-G motif; other site 693974002997 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974002998 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 693974002999 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974003000 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974003001 metal binding site [ion binding]; metal-binding site 693974003002 active site 693974003003 I-site; other site 693974003004 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974003005 TIGR03899 family protein; Region: TIGR03899 693974003006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974003007 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693974003008 putative substrate translocation pore; other site 693974003009 Flavodoxin domain; Region: Flavodoxin_5; cl17428 693974003010 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 693974003011 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 693974003012 catalytic residues [active] 693974003013 hinge region; other site 693974003014 alpha helical domain; other site 693974003015 GlyGly-CTERM domain; Region: GlyGly_CTERM; TIGR03501 693974003016 DNA-J related protein; Region: DNAJ_related; pfam12339 693974003017 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693974003018 HSP70 interaction site [polypeptide binding]; other site 693974003019 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 693974003020 FMN binding site [chemical binding]; other site 693974003021 dimer interface [polypeptide binding]; other site 693974003022 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693974003023 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693974003024 Walker A/P-loop; other site 693974003025 ATP binding site [chemical binding]; other site 693974003026 Q-loop/lid; other site 693974003027 ABC transporter signature motif; other site 693974003028 Walker B; other site 693974003029 D-loop; other site 693974003030 H-loop/switch region; other site 693974003031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974003032 dimer interface [polypeptide binding]; other site 693974003033 conserved gate region; other site 693974003034 putative PBP binding loops; other site 693974003035 ABC-ATPase subunit interface; other site 693974003036 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974003037 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974003038 substrate binding pocket [chemical binding]; other site 693974003039 membrane-bound complex binding site; other site 693974003040 hinge residues; other site 693974003041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974003042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974003043 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 693974003044 putative dimerization interface [polypeptide binding]; other site 693974003045 LrgA family; Region: LrgA; cl00608 693974003046 LrgB-like family; Region: LrgB; pfam04172 693974003047 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693974003048 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693974003049 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 693974003050 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 693974003051 Rhomboid family; Region: Rhomboid; pfam01694 693974003052 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 693974003053 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693974003054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693974003055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693974003056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693974003057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693974003058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693974003059 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 693974003060 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 693974003061 Nucleoside recognition; Region: Gate; pfam07670 693974003062 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 693974003063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974003064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974003065 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974003066 putative effector binding pocket; other site 693974003067 dimerization interface [polypeptide binding]; other site 693974003068 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 693974003069 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693974003070 Cytochrome c; Region: Cytochrom_C; pfam00034 693974003071 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693974003072 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693974003073 Cytochrome c; Region: Cytochrom_C; pfam00034 693974003074 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693974003075 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 693974003076 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693974003077 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693974003078 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693974003079 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693974003080 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693974003081 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 693974003082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974003083 Walker A motif; other site 693974003084 ATP binding site [chemical binding]; other site 693974003085 Walker B motif; other site 693974003086 Family description; Region: UvrD_C_2; pfam13538 693974003087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974003088 PAS domain; Region: PAS_9; pfam13426 693974003089 putative active site [active] 693974003090 heme pocket [chemical binding]; other site 693974003091 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974003092 PAS domain; Region: PAS_9; pfam13426 693974003093 putative active site [active] 693974003094 heme pocket [chemical binding]; other site 693974003095 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974003096 dimer interface [polypeptide binding]; other site 693974003097 putative CheW interface [polypeptide binding]; other site 693974003098 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 693974003099 classical (c) SDRs; Region: SDR_c; cd05233 693974003100 NAD(P) binding site [chemical binding]; other site 693974003101 active site 693974003102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974003103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974003104 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974003105 putative effector binding pocket; other site 693974003106 dimerization interface [polypeptide binding]; other site 693974003107 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 693974003108 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 693974003109 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 693974003110 substrate binding pocket [chemical binding]; other site 693974003111 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 693974003112 B12 binding site [chemical binding]; other site 693974003113 cobalt ligand [ion binding]; other site 693974003114 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 693974003115 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693974003116 catalytic core [active] 693974003117 AAA domain; Region: AAA_31; pfam13614 693974003118 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693974003119 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693974003120 Walker A/P-loop; other site 693974003121 ATP binding site [chemical binding]; other site 693974003122 Q-loop/lid; other site 693974003123 ABC transporter signature motif; other site 693974003124 Walker B; other site 693974003125 D-loop; other site 693974003126 H-loop/switch region; other site 693974003127 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 693974003128 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693974003129 ABC-ATPase subunit interface; other site 693974003130 dimer interface [polypeptide binding]; other site 693974003131 putative PBP binding regions; other site 693974003132 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 693974003133 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 693974003134 putative dimer interface [polypeptide binding]; other site 693974003135 active site pocket [active] 693974003136 putative cataytic base [active] 693974003137 cobalamin synthase; Reviewed; Region: cobS; PRK00235 693974003138 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 693974003139 homotrimer interface [polypeptide binding]; other site 693974003140 Walker A motif; other site 693974003141 GTP binding site [chemical binding]; other site 693974003142 Walker B motif; other site 693974003143 cobyric acid synthase; Provisional; Region: PRK00784 693974003144 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 693974003145 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 693974003146 catalytic triad [active] 693974003147 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 693974003148 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 693974003149 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 693974003150 homodimer interface [polypeptide binding]; other site 693974003151 Walker A motif; other site 693974003152 ATP binding site [chemical binding]; other site 693974003153 hydroxycobalamin binding site [chemical binding]; other site 693974003154 Walker B motif; other site 693974003155 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 693974003156 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 693974003157 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 693974003158 cobalamin binding residues [chemical binding]; other site 693974003159 putative BtuC binding residues; other site 693974003160 dimer interface [polypeptide binding]; other site 693974003161 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693974003162 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 693974003163 NAD(P) binding site [chemical binding]; other site 693974003164 catalytic residues [active] 693974003165 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 693974003166 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 693974003167 dimer interface [polypeptide binding]; other site 693974003168 active site 693974003169 metal binding site [ion binding]; metal-binding site 693974003170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693974003171 Transposase; Region: HTH_Tnp_1; pfam01527 693974003172 putative transposase OrfB; Reviewed; Region: PHA02517 693974003173 HTH-like domain; Region: HTH_21; pfam13276 693974003174 Integrase core domain; Region: rve; pfam00665 693974003175 Integrase core domain; Region: rve_3; pfam13683 693974003176 FRG domain; Region: FRG; cl07460 693974003177 glutamate racemase; Provisional; Region: PRK00865 693974003178 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 693974003179 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 693974003180 active site 693974003181 substrate binding pocket [chemical binding]; other site 693974003182 dimer interface [polypeptide binding]; other site 693974003183 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693974003184 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974003185 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974003186 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693974003187 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693974003188 Walker A/P-loop; other site 693974003189 ATP binding site [chemical binding]; other site 693974003190 Q-loop/lid; other site 693974003191 ABC transporter signature motif; other site 693974003192 Walker B; other site 693974003193 D-loop; other site 693974003194 H-loop/switch region; other site 693974003195 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693974003196 FtsX-like permease family; Region: FtsX; pfam02687 693974003197 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693974003198 FtsX-like permease family; Region: FtsX; pfam02687 693974003199 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693974003200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974003201 active site 693974003202 phosphorylation site [posttranslational modification] 693974003203 intermolecular recognition site; other site 693974003204 dimerization interface [polypeptide binding]; other site 693974003205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974003206 Walker A motif; other site 693974003207 ATP binding site [chemical binding]; other site 693974003208 Walker B motif; other site 693974003209 arginine finger; other site 693974003210 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693974003211 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 693974003212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974003213 ATP binding site [chemical binding]; other site 693974003214 Mg2+ binding site [ion binding]; other site 693974003215 G-X-G motif; other site 693974003216 Curli assembly protein CsgE; Region: CsgE; pfam10627 693974003217 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 693974003218 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 693974003219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693974003220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974003221 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 693974003222 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 693974003223 NAD(P) binding site [chemical binding]; other site 693974003224 catalytic residues [active] 693974003225 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 693974003226 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693974003227 Ligand Binding Site [chemical binding]; other site 693974003228 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693974003229 Ligand Binding Site [chemical binding]; other site 693974003230 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974003231 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974003232 membrane-bound complex binding site; other site 693974003233 hinge residues; other site 693974003234 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 693974003235 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904 693974003236 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 693974003237 gamma-glutamyl kinase; Provisional; Region: PRK05429 693974003238 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 693974003239 nucleotide binding site [chemical binding]; other site 693974003240 homotetrameric interface [polypeptide binding]; other site 693974003241 putative phosphate binding site [ion binding]; other site 693974003242 putative allosteric binding site; other site 693974003243 PUA domain; Region: PUA; pfam01472 693974003244 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 693974003245 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 693974003246 putative catalytic cysteine [active] 693974003247 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 693974003248 putative deacylase active site [active] 693974003249 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693974003250 EamA-like transporter family; Region: EamA; pfam00892 693974003251 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 693974003252 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693974003253 nucleotide binding site [chemical binding]; other site 693974003254 chaperone protein DnaJ; Provisional; Region: PRK10767 693974003255 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693974003256 HSP70 interaction site [polypeptide binding]; other site 693974003257 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 693974003258 substrate binding site [polypeptide binding]; other site 693974003259 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 693974003260 Zn binding sites [ion binding]; other site 693974003261 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 693974003262 dimer interface [polypeptide binding]; other site 693974003263 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 693974003264 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 693974003265 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 693974003266 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693974003267 ATP binding site [chemical binding]; other site 693974003268 putative Mg++ binding site [ion binding]; other site 693974003269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974003270 nucleotide binding region [chemical binding]; other site 693974003271 ATP-binding site [chemical binding]; other site 693974003272 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693974003273 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693974003274 Peptidase family M48; Region: Peptidase_M48; pfam01435 693974003275 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 693974003276 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 693974003277 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693974003278 dihydrodipicolinate reductase; Provisional; Region: PRK00048 693974003279 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 693974003280 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 693974003281 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 693974003282 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 693974003283 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 693974003284 catalytic site [active] 693974003285 subunit interface [polypeptide binding]; other site 693974003286 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 693974003287 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693974003288 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693974003289 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 693974003290 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693974003291 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693974003292 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 693974003293 IMP binding site; other site 693974003294 dimer interface [polypeptide binding]; other site 693974003295 interdomain contacts; other site 693974003296 partial ornithine binding site; other site 693974003297 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693974003298 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693974003299 active site 693974003300 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974003301 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974003302 substrate binding pocket [chemical binding]; other site 693974003303 membrane-bound complex binding site; other site 693974003304 hinge residues; other site 693974003305 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974003306 dimer interface [polypeptide binding]; other site 693974003307 putative CheW interface [polypeptide binding]; other site 693974003308 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 693974003309 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 693974003310 MgtE intracellular N domain; Region: MgtE_N; pfam03448 693974003311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 693974003312 Divalent cation transporter; Region: MgtE; pfam01769 693974003313 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693974003314 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693974003315 putative catalytic site [active] 693974003316 putative metal binding site [ion binding]; other site 693974003317 putative metal binding site [ion binding]; other site 693974003318 putative phosphate binding site [ion binding]; other site 693974003319 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693974003320 putative catalytic site [active] 693974003321 putative phosphate binding site [ion binding]; other site 693974003322 putative metal binding site [ion binding]; other site 693974003323 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 693974003324 hypothetical protein; Provisional; Region: PRK05409 693974003325 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 693974003326 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 693974003327 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 693974003328 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 693974003329 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 693974003330 putative RNA binding site [nucleotide binding]; other site 693974003331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974003332 S-adenosylmethionine binding site [chemical binding]; other site 693974003333 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 693974003334 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693974003335 active site 693974003336 dimer interface [polypeptide binding]; other site 693974003337 Protein of unknown function (DUF808); Region: DUF808; pfam05661 693974003338 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 693974003339 catalytic site [active] 693974003340 putative active site [active] 693974003341 putative substrate binding site [chemical binding]; other site 693974003342 SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102 693974003343 SEC-C motif; Region: SEC-C; pfam02810 693974003344 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693974003345 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974003346 N-terminal plug; other site 693974003347 ligand-binding site [chemical binding]; other site 693974003348 Predicted membrane protein [Function unknown]; Region: COG3503 693974003349 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 693974003350 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 693974003351 dimerization interface [polypeptide binding]; other site 693974003352 DPS ferroxidase diiron center [ion binding]; other site 693974003353 ion pore; other site 693974003354 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 693974003355 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 693974003356 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693974003357 lipoyl synthase; Provisional; Region: PRK05481 693974003358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974003359 FeS/SAM binding site; other site 693974003360 lipoate-protein ligase B; Provisional; Region: PRK14342 693974003361 hypothetical protein; Provisional; Region: PRK04998 693974003362 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 693974003363 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 693974003364 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 693974003365 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 693974003366 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 693974003367 Sporulation related domain; Region: SPOR; pfam05036 693974003368 Transglycosylase SLT domain; Region: SLT_2; pfam13406 693974003369 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693974003370 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693974003371 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 693974003372 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 693974003373 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 693974003374 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693974003375 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 693974003376 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 693974003377 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 693974003378 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 693974003379 active site 693974003380 (T/H)XGH motif; other site 693974003381 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 693974003382 DNA polymerase III, delta subunit; Region: holA; TIGR01128 693974003383 Lipopolysaccharide-assembly; Region: LptE; cl01125 693974003384 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 693974003385 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 693974003386 HIGH motif; other site 693974003387 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 693974003388 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693974003389 active site 693974003390 KMSKS motif; other site 693974003391 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 693974003392 tRNA binding surface [nucleotide binding]; other site 693974003393 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 693974003394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974003395 S-adenosylmethionine binding site [chemical binding]; other site 693974003396 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 693974003397 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 693974003398 putative active site [active] 693974003399 catalytic triad [active] 693974003400 putative dimer interface [polypeptide binding]; other site 693974003401 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 693974003402 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693974003403 Transporter associated domain; Region: CorC_HlyC; smart01091 693974003404 metal-binding heat shock protein; Provisional; Region: PRK00016 693974003405 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 693974003406 PhoH-like protein; Region: PhoH; pfam02562 693974003407 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 693974003408 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693974003409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974003410 FeS/SAM binding site; other site 693974003411 TRAM domain; Region: TRAM; pfam01938 693974003412 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849 693974003413 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693974003414 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 693974003415 putative active site [active] 693974003416 catalytic residue [active] 693974003417 GTP-binding protein YchF; Reviewed; Region: PRK09601 693974003418 YchF GTPase; Region: YchF; cd01900 693974003419 G1 box; other site 693974003420 GTP/Mg2+ binding site [chemical binding]; other site 693974003421 Switch I region; other site 693974003422 G2 box; other site 693974003423 Switch II region; other site 693974003424 G3 box; other site 693974003425 G4 box; other site 693974003426 G5 box; other site 693974003427 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 693974003428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 693974003429 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 693974003430 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 693974003431 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 693974003432 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693974003433 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693974003434 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933 693974003435 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 693974003436 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 693974003437 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13021 693974003438 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 693974003439 Protein export membrane protein; Region: SecD_SecF; pfam02355 693974003440 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 693974003441 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 693974003442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974003443 S-adenosylmethionine binding site [chemical binding]; other site 693974003444 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 693974003445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974003446 Walker A motif; other site 693974003447 ATP binding site [chemical binding]; other site 693974003448 Walker B motif; other site 693974003449 arginine finger; other site 693974003450 Peptidase family M41; Region: Peptidase_M41; pfam01434 693974003451 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 693974003452 dihydropteroate synthase; Region: DHPS; TIGR01496 693974003453 substrate binding pocket [chemical binding]; other site 693974003454 dimer interface [polypeptide binding]; other site 693974003455 inhibitor binding site; inhibition site 693974003456 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 693974003457 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 693974003458 active site 693974003459 substrate binding site [chemical binding]; other site 693974003460 metal binding site [ion binding]; metal-binding site 693974003461 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 693974003462 triosephosphate isomerase; Provisional; Region: PRK14567 693974003463 substrate binding site [chemical binding]; other site 693974003464 dimer interface [polypeptide binding]; other site 693974003465 catalytic triad [active] 693974003466 Preprotein translocase SecG subunit; Region: SecG; pfam03840 693974003467 ribosome maturation protein RimP; Reviewed; Region: PRK00092 693974003468 Sm and related proteins; Region: Sm_like; cl00259 693974003469 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 693974003470 putative oligomer interface [polypeptide binding]; other site 693974003471 putative RNA binding site [nucleotide binding]; other site 693974003472 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 693974003473 NusA N-terminal domain; Region: NusA_N; pfam08529 693974003474 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 693974003475 RNA binding site [nucleotide binding]; other site 693974003476 homodimer interface [polypeptide binding]; other site 693974003477 NusA-like KH domain; Region: KH_5; pfam13184 693974003478 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 693974003479 G-X-X-G motif; other site 693974003480 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 693974003481 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 693974003482 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 693974003483 translation initiation factor IF-2; Region: IF-2; TIGR00487 693974003484 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 693974003485 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 693974003486 G1 box; other site 693974003487 putative GEF interaction site [polypeptide binding]; other site 693974003488 GTP/Mg2+ binding site [chemical binding]; other site 693974003489 Switch I region; other site 693974003490 G2 box; other site 693974003491 G3 box; other site 693974003492 Switch II region; other site 693974003493 G4 box; other site 693974003494 G5 box; other site 693974003495 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 693974003496 Translation-initiation factor 2; Region: IF-2; pfam11987 693974003497 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 693974003498 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 693974003499 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 693974003500 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 693974003501 RNA binding site [nucleotide binding]; other site 693974003502 active site 693974003503 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 693974003504 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 693974003505 16S/18S rRNA binding site [nucleotide binding]; other site 693974003506 S13e-L30e interaction site [polypeptide binding]; other site 693974003507 25S rRNA binding site [nucleotide binding]; other site 693974003508 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974003509 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974003510 metal binding site [ion binding]; metal-binding site 693974003511 active site 693974003512 I-site; other site 693974003513 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974003514 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 693974003515 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 693974003516 RNase E interface [polypeptide binding]; other site 693974003517 trimer interface [polypeptide binding]; other site 693974003518 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 693974003519 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 693974003520 RNase E interface [polypeptide binding]; other site 693974003521 trimer interface [polypeptide binding]; other site 693974003522 active site 693974003523 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 693974003524 putative nucleic acid binding region [nucleotide binding]; other site 693974003525 G-X-X-G motif; other site 693974003526 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 693974003527 RNA binding site [nucleotide binding]; other site 693974003528 domain interface; other site 693974003529 lipoprotein NlpI; Provisional; Region: PRK11189 693974003530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974003531 binding surface 693974003532 TPR motif; other site 693974003533 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 693974003534 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 693974003535 G1 box; other site 693974003536 putative GEF interaction site [polypeptide binding]; other site 693974003537 GTP/Mg2+ binding site [chemical binding]; other site 693974003538 Switch I region; other site 693974003539 G2 box; other site 693974003540 G3 box; other site 693974003541 Switch II region; other site 693974003542 G4 box; other site 693974003543 G5 box; other site 693974003544 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 693974003545 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693974003546 active site 693974003547 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 693974003548 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 693974003549 Nucleoside recognition; Region: Gate; pfam07670 693974003550 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 693974003551 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 693974003552 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 693974003553 intersubunit interface [polypeptide binding]; other site 693974003554 active site 693974003555 catalytic residue [active] 693974003556 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 693974003557 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693974003558 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693974003559 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 693974003560 phosphopentomutase; Provisional; Region: PRK05362 693974003561 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 693974003562 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 693974003563 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 693974003564 phosphoserine phosphatase SerB; Region: serB; TIGR00338 693974003565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974003566 motif II; other site 693974003567 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693974003568 PilZ domain; Region: PilZ; pfam07238 693974003569 PilZ domain; Region: PilZ; pfam07238 693974003570 DNA repair protein RadA; Provisional; Region: PRK11823 693974003571 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 693974003572 Walker A motif/ATP binding site; other site 693974003573 ATP binding site [chemical binding]; other site 693974003574 Walker B motif; other site 693974003575 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693974003576 PilZ domain; Region: PilZ; pfam07238 693974003577 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 693974003578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974003579 active site 693974003580 phosphorylation site [posttranslational modification] 693974003581 intermolecular recognition site; other site 693974003582 dimerization interface [polypeptide binding]; other site 693974003583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974003584 DNA binding site [nucleotide binding] 693974003585 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 693974003586 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 693974003587 putative ligand binding site [chemical binding]; other site 693974003588 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 693974003589 HAMP domain; Region: HAMP; pfam00672 693974003590 dimerization interface [polypeptide binding]; other site 693974003591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974003592 dimer interface [polypeptide binding]; other site 693974003593 phosphorylation site [posttranslational modification] 693974003594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974003595 ATP binding site [chemical binding]; other site 693974003596 Mg2+ binding site [ion binding]; other site 693974003597 G-X-G motif; other site 693974003598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974003599 active site 693974003600 phosphorylation site [posttranslational modification] 693974003601 intermolecular recognition site; other site 693974003602 dimerization interface [polypeptide binding]; other site 693974003603 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693974003604 putative binding surface; other site 693974003605 active site 693974003606 chaperone protein TorD; Validated; Region: torD; PRK04976 693974003607 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 693974003608 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 693974003609 molybdopterin cofactor binding site [chemical binding]; other site 693974003610 substrate binding site [chemical binding]; other site 693974003611 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 693974003612 molybdopterin cofactor binding site; other site 693974003613 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 693974003614 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 693974003615 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 693974003616 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 693974003617 FOG: CBS domain [General function prediction only]; Region: COG0517 693974003618 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_24; cd04637 693974003619 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 693974003620 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693974003621 putative acyl-acceptor binding pocket; other site 693974003622 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 693974003623 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 693974003624 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693974003625 putative active site [active] 693974003626 putative metal binding site [ion binding]; other site 693974003627 SIR2-like domain; Region: SIR2_2; pfam13289 693974003628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 693974003629 Nucleoside recognition; Region: Gate; pfam07670 693974003630 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 693974003631 putative protease; Provisional; Region: PRK15447 693974003632 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693974003633 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693974003634 Peptidase family U32; Region: Peptidase_U32; pfam01136 693974003635 SCP-2 sterol transfer family; Region: SCP2; cl01225 693974003636 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 693974003637 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 693974003638 calcium binding site 2 [ion binding]; other site 693974003639 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 693974003640 active site 693974003641 catalytic triad [active] 693974003642 calcium binding site 1 [ion binding]; other site 693974003643 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693974003644 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693974003645 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693974003646 putative protease; Provisional; Region: PRK15452 693974003647 Peptidase family U32; Region: Peptidase_U32; pfam01136 693974003648 HDOD domain; Region: HDOD; pfam08668 693974003649 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974003650 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974003651 metal binding site [ion binding]; metal-binding site 693974003652 active site 693974003653 I-site; other site 693974003654 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974003655 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693974003656 active site 693974003657 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 693974003658 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974003659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974003660 active site 693974003661 phosphorylation site [posttranslational modification] 693974003662 intermolecular recognition site; other site 693974003663 dimerization interface [polypeptide binding]; other site 693974003664 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 693974003665 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 693974003666 GDP-binding site [chemical binding]; other site 693974003667 ACT binding site; other site 693974003668 IMP binding site; other site 693974003669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974003670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974003671 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693974003672 dimerization interface [polypeptide binding]; other site 693974003673 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974003674 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 693974003675 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 693974003676 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974003677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974003678 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693974003679 dimerization interface [polypeptide binding]; other site 693974003680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693974003681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974003682 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693974003683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974003684 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974003685 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 693974003686 Cna protein B-type domain; Region: Cna_B; pfam05738 693974003687 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974003688 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974003689 metal binding site [ion binding]; metal-binding site 693974003690 active site 693974003691 I-site; other site 693974003692 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974003693 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 693974003694 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 693974003695 apolar tunnel; other site 693974003696 heme binding site [chemical binding]; other site 693974003697 dimerization interface [polypeptide binding]; other site 693974003698 Uncharacterized conserved protein [Function unknown]; Region: COG1432 693974003699 LabA_like proteins; Region: LabA_like/DUF88; cl10034 693974003700 putative metal binding site [ion binding]; other site 693974003701 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693974003702 EamA-like transporter family; Region: EamA; pfam00892 693974003703 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693974003704 EamA-like transporter family; Region: EamA; pfam00892 693974003705 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693974003706 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693974003707 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974003708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974003709 putative substrate translocation pore; other site 693974003710 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693974003711 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693974003712 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974003713 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974003714 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974003715 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974003716 substrate binding pocket [chemical binding]; other site 693974003717 membrane-bound complex binding site; other site 693974003718 hinge residues; other site 693974003719 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 693974003720 active site 693974003721 metal binding site [ion binding]; metal-binding site 693974003722 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 693974003723 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 693974003724 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 693974003725 catalytic residues [active] 693974003726 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693974003727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974003728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974003729 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974003730 putative effector binding pocket; other site 693974003731 dimerization interface [polypeptide binding]; other site 693974003732 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 693974003733 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974003734 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974003735 ABC transporter; Region: ABC_tran_2; pfam12848 693974003736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974003737 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 693974003738 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 693974003739 dimer interface [polypeptide binding]; other site 693974003740 active site 693974003741 glycine-pyridoxal phosphate binding site [chemical binding]; other site 693974003742 folate binding site [chemical binding]; other site 693974003743 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 693974003744 ATP cone domain; Region: ATP-cone; pfam03477 693974003745 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 693974003746 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 693974003747 catalytic motif [active] 693974003748 Zn binding site [ion binding]; other site 693974003749 RibD C-terminal domain; Region: RibD_C; cl17279 693974003750 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 693974003751 Lumazine binding domain; Region: Lum_binding; pfam00677 693974003752 Lumazine binding domain; Region: Lum_binding; pfam00677 693974003753 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 693974003754 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 693974003755 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 693974003756 dimerization interface [polypeptide binding]; other site 693974003757 active site 693974003758 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 693974003759 homopentamer interface [polypeptide binding]; other site 693974003760 active site 693974003761 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 693974003762 putative RNA binding site [nucleotide binding]; other site 693974003763 thiamine monophosphate kinase; Provisional; Region: PRK05731 693974003764 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 693974003765 ATP binding site [chemical binding]; other site 693974003766 dimerization interface [polypeptide binding]; other site 693974003767 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 693974003768 tetramer interfaces [polypeptide binding]; other site 693974003769 binuclear metal-binding site [ion binding]; other site 693974003770 recombination and repair protein; Provisional; Region: PRK10869 693974003771 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693974003772 Walker A/P-loop; other site 693974003773 ATP binding site [chemical binding]; other site 693974003774 Q-loop/lid; other site 693974003775 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693974003776 ABC transporter signature motif; other site 693974003777 Walker B; other site 693974003778 D-loop; other site 693974003779 H-loop/switch region; other site 693974003780 Membrane transport protein; Region: Mem_trans; cl09117 693974003781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974003782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974003783 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974003784 putative effector binding pocket; other site 693974003785 dimerization interface [polypeptide binding]; other site 693974003786 Protein of unknown function (DUF3319); Region: DUF3319; pfam11782 693974003787 Protein of unknown function (DUF416); Region: DUF416; pfam04222 693974003788 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 693974003789 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 693974003790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974003791 dimerization interface [polypeptide binding]; other site 693974003792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974003793 dimer interface [polypeptide binding]; other site 693974003794 phosphorylation site [posttranslational modification] 693974003795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974003796 ATP binding site [chemical binding]; other site 693974003797 Mg2+ binding site [ion binding]; other site 693974003798 G-X-G motif; other site 693974003799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974003800 active site 693974003801 phosphorylation site [posttranslational modification] 693974003802 intermolecular recognition site; other site 693974003803 dimerization interface [polypeptide binding]; other site 693974003804 Hpt domain; Region: Hpt; pfam01627 693974003805 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 693974003806 TRAM domain; Region: TRAM; pfam01938 693974003807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974003808 S-adenosylmethionine binding site [chemical binding]; other site 693974003809 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 693974003810 HD domain; Region: HD_4; pfam13328 693974003811 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693974003812 synthetase active site [active] 693974003813 NTP binding site [chemical binding]; other site 693974003814 metal binding site [ion binding]; metal-binding site 693974003815 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 693974003816 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 693974003817 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 693974003818 AAA domain; Region: AAA_11; pfam13086 693974003819 Part of AAA domain; Region: AAA_19; pfam13245 693974003820 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 693974003821 AAA domain; Region: AAA_12; pfam13087 693974003822 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 693974003823 putative active site [active] 693974003824 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 693974003825 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 693974003826 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 693974003827 substrate binding site [chemical binding]; other site 693974003828 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Provisional; Region: PRK08575 693974003829 THF binding site; other site 693974003830 zinc-binding site [ion binding]; other site 693974003831 amidase; Validated; Region: PRK06565 693974003832 Amidase; Region: Amidase; cl11426 693974003833 agmatine deiminase; Provisional; Region: PRK13551 693974003834 agmatine deiminase; Region: agmatine_aguA; TIGR03380 693974003835 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 693974003836 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 693974003837 homodimer interface [polypeptide binding]; other site 693974003838 metal binding site [ion binding]; metal-binding site 693974003839 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 693974003840 homodimer interface [polypeptide binding]; other site 693974003841 active site 693974003842 putative chemical substrate binding site [chemical binding]; other site 693974003843 metal binding site [ion binding]; metal-binding site 693974003844 CTP synthetase; Validated; Region: pyrG; PRK05380 693974003845 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 693974003846 Catalytic site [active] 693974003847 active site 693974003848 UTP binding site [chemical binding]; other site 693974003849 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 693974003850 active site 693974003851 putative oxyanion hole; other site 693974003852 catalytic triad [active] 693974003853 enolase; Provisional; Region: eno; PRK00077 693974003854 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 693974003855 dimer interface [polypeptide binding]; other site 693974003856 metal binding site [ion binding]; metal-binding site 693974003857 substrate binding pocket [chemical binding]; other site 693974003858 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 693974003859 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 693974003860 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 693974003861 substrate binding site; other site 693974003862 dimer interface; other site 693974003863 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 693974003864 homotrimer interaction site [polypeptide binding]; other site 693974003865 zinc binding site [ion binding]; other site 693974003866 CDP-binding sites; other site 693974003867 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 693974003868 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 693974003869 Permutation of conserved domain; other site 693974003870 active site 693974003871 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 693974003872 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 693974003873 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 693974003874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974003875 S-adenosylmethionine binding site [chemical binding]; other site 693974003876 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 693974003877 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693974003878 Peptidase family M23; Region: Peptidase_M23; pfam01551 693974003879 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 693974003880 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 693974003881 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693974003882 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693974003883 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693974003884 DNA binding residues [nucleotide binding] 693974003885 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 693974003886 MutS domain I; Region: MutS_I; pfam01624 693974003887 MutS domain II; Region: MutS_II; pfam05188 693974003888 MutS domain III; Region: MutS_III; pfam05192 693974003889 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 693974003890 Walker A/P-loop; other site 693974003891 ATP binding site [chemical binding]; other site 693974003892 Q-loop/lid; other site 693974003893 ABC transporter signature motif; other site 693974003894 Walker B; other site 693974003895 D-loop; other site 693974003896 H-loop/switch region; other site 693974003897 recombinase A; Provisional; Region: recA; PRK09354 693974003898 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 693974003899 hexamer interface [polypeptide binding]; other site 693974003900 Walker A motif; other site 693974003901 ATP binding site [chemical binding]; other site 693974003902 Walker B motif; other site 693974003903 RecX family; Region: RecX; pfam02631 693974003904 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 693974003905 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 693974003906 motif 1; other site 693974003907 active site 693974003908 motif 2; other site 693974003909 motif 3; other site 693974003910 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 693974003911 DHHA1 domain; Region: DHHA1; pfam02272 693974003912 aspartate kinase; Reviewed; Region: PRK06635 693974003913 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 693974003914 putative nucleotide binding site [chemical binding]; other site 693974003915 putative catalytic residues [active] 693974003916 putative Mg ion binding site [ion binding]; other site 693974003917 putative aspartate binding site [chemical binding]; other site 693974003918 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 693974003919 putative allosteric regulatory residue; other site 693974003920 carbon storage regulator; Provisional; Region: PRK01712 693974003921 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 693974003922 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 693974003923 HIGH motif; other site 693974003924 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 693974003925 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 693974003926 active site 693974003927 KMSKS motif; other site 693974003928 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 693974003929 tRNA binding surface [nucleotide binding]; other site 693974003930 anticodon binding site; other site 693974003931 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 693974003932 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 693974003933 PAS domain S-box; Region: sensory_box; TIGR00229 693974003934 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974003935 putative active site [active] 693974003936 heme pocket [chemical binding]; other site 693974003937 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974003938 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974003939 metal binding site [ion binding]; metal-binding site 693974003940 active site 693974003941 I-site; other site 693974003942 multifunctional aminopeptidase A; Provisional; Region: PRK00913 693974003943 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693974003944 interface (dimer of trimers) [polypeptide binding]; other site 693974003945 Substrate-binding/catalytic site; other site 693974003946 Zn-binding sites [ion binding]; other site 693974003947 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 693974003948 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693974003949 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 693974003950 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693974003951 RDD family; Region: RDD; pfam06271 693974003952 Protein of unknown function (DUF2960); Region: DUF2960; pfam11173 693974003953 Protein of unknown function, DUF486; Region: DUF486; pfam04342 693974003954 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 693974003955 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 693974003956 active site 693974003957 Zn binding site [ion binding]; other site 693974003958 DsrE/DsrF-like family; Region: DrsE; pfam02635 693974003959 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 693974003960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 693974003961 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 693974003962 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 693974003963 hypothetical protein; Provisional; Region: PRK09898 693974003964 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693974003965 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693974003966 putative oxidoreductase; Provisional; Region: PRK09849 693974003967 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 693974003968 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 693974003969 hypothetical protein; Provisional; Region: PRK09947 693974003970 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974003971 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974003972 membrane-bound complex binding site; other site 693974003973 hinge residues; other site 693974003974 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 693974003975 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 693974003976 putative catalytic residues [active] 693974003977 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 693974003978 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 693974003979 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 693974003980 putrescine transporter; Provisional; Region: potE; PRK10655 693974003981 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 693974003982 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693974003983 ATP binding site [chemical binding]; other site 693974003984 Mg++ binding site [ion binding]; other site 693974003985 motif III; other site 693974003986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974003987 nucleotide binding region [chemical binding]; other site 693974003988 ATP-binding site [chemical binding]; other site 693974003989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974003990 PAS fold; Region: PAS_3; pfam08447 693974003991 putative active site [active] 693974003992 heme pocket [chemical binding]; other site 693974003993 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974003994 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974003995 dimer interface [polypeptide binding]; other site 693974003996 putative CheW interface [polypeptide binding]; other site 693974003997 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 693974003998 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693974003999 Zn2+ binding site [ion binding]; other site 693974004000 Mg2+ binding site [ion binding]; other site 693974004001 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 693974004002 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 693974004003 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 693974004004 active site 693974004005 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693974004006 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693974004007 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 693974004008 Glyco_18 domain; Region: Glyco_18; smart00636 693974004009 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 693974004010 active site 693974004011 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 693974004012 aromatic chitin/cellulose binding site residues [chemical binding]; other site 693974004013 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 693974004014 aromatic chitin/cellulose binding site residues [chemical binding]; other site 693974004015 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 693974004016 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 693974004017 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693974004018 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 693974004019 HPP family; Region: HPP; pfam04982 693974004020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693974004021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974004022 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 693974004023 Predicted membrane protein [Function unknown]; Region: COG2311 693974004024 Protein of unknown function (DUF418); Region: DUF418; cl12135 693974004025 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 693974004026 nucleoside/Zn binding site; other site 693974004027 dimer interface [polypeptide binding]; other site 693974004028 catalytic motif [active] 693974004029 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693974004030 CoenzymeA binding site [chemical binding]; other site 693974004031 subunit interaction site [polypeptide binding]; other site 693974004032 PHB binding site; other site 693974004033 Domain of unknown function (DUF368); Region: DUF368; pfam04018 693974004034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 693974004035 YheO-like PAS domain; Region: PAS_6; pfam08348 693974004036 HTH domain; Region: HTH_22; pfam13309 693974004037 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 693974004038 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693974004039 homotrimer interaction site [polypeptide binding]; other site 693974004040 putative active site [active] 693974004041 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693974004042 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 693974004043 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974004044 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693974004045 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974004046 dimer interface [polypeptide binding]; other site 693974004047 putative CheW interface [polypeptide binding]; other site 693974004048 PBP superfamily domain; Region: PBP_like_2; cl17296 693974004049 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 693974004050 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 693974004051 MerT mercuric transport protein; Region: MerT; cl03578 693974004052 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693974004053 metal-binding site [ion binding] 693974004054 Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237 693974004055 Protein of unknown function (DUF523); Region: DUF523; pfam04463 693974004056 Uncharacterized conserved protein [Function unknown]; Region: COG3272 693974004057 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 693974004058 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693974004059 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 693974004060 DNA binding residues [nucleotide binding] 693974004061 DNA photolyase; Region: DNA_photolyase; pfam00875 693974004062 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 693974004063 SnoaL-like domain; Region: SnoaL_2; pfam12680 693974004064 short chain dehydrogenase; Provisional; Region: PRK06101 693974004065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974004066 NAD(P) binding site [chemical binding]; other site 693974004067 active site 693974004068 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 693974004069 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693974004070 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693974004071 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 693974004072 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 693974004073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974004074 S-adenosylmethionine binding site [chemical binding]; other site 693974004075 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 693974004076 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 693974004077 Protein of unknown function (DUF3634); Region: DUF3634; pfam12321 693974004078 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 693974004079 hypothetical protein; Provisional; Region: PRK03757 693974004080 oxidative damage protection protein; Provisional; Region: PRK05408 693974004081 adenine DNA glycosylase; Provisional; Region: PRK10880 693974004082 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693974004083 minor groove reading motif; other site 693974004084 helix-hairpin-helix signature motif; other site 693974004085 substrate binding pocket [chemical binding]; other site 693974004086 active site 693974004087 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 693974004088 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 693974004089 DNA binding and oxoG recognition site [nucleotide binding] 693974004090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974004091 S-adenosylmethionine binding site [chemical binding]; other site 693974004092 hypothetical protein; Provisional; Region: PRK11702 693974004093 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 693974004094 glutaminase; Provisional; Region: PRK00971 693974004095 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 693974004096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974004097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974004098 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974004099 putative effector binding pocket; other site 693974004100 dimerization interface [polypeptide binding]; other site 693974004101 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 693974004102 HemN family oxidoreductase; Provisional; Region: PRK05660 693974004103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974004104 FeS/SAM binding site; other site 693974004105 HemN C-terminal domain; Region: HemN_C; pfam06969 693974004106 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 693974004107 active site 693974004108 dimerization interface [polypeptide binding]; other site 693974004109 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 693974004110 hypothetical protein; Validated; Region: PRK05090 693974004111 YGGT family; Region: YGGT; pfam02325 693974004112 YGGT family; Region: YGGT; pfam02325 693974004113 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 693974004114 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 693974004115 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 693974004116 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693974004117 catalytic residue [active] 693974004118 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 693974004119 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 693974004120 Walker A motif; other site 693974004121 ATP binding site [chemical binding]; other site 693974004122 Walker B motif; other site 693974004123 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 693974004124 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693974004125 Walker A motif; other site 693974004126 ATP binding site [chemical binding]; other site 693974004127 Walker B motif; other site 693974004128 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 693974004129 catalytic residues [active] 693974004130 dimer interface [polypeptide binding]; other site 693974004131 ferrochelatase; Reviewed; Region: hemH; PRK00035 693974004132 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 693974004133 C-terminal domain interface [polypeptide binding]; other site 693974004134 active site 693974004135 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 693974004136 active site 693974004137 N-terminal domain interface [polypeptide binding]; other site 693974004138 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 693974004139 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 693974004140 translation initiation factor Sui1; Validated; Region: PRK06824 693974004141 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 693974004142 putative rRNA binding site [nucleotide binding]; other site 693974004143 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 693974004144 Predicted membrane protein [Function unknown]; Region: COG2860 693974004145 UPF0126 domain; Region: UPF0126; pfam03458 693974004146 UPF0126 domain; Region: UPF0126; pfam03458 693974004147 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 693974004148 dimer interface [polypeptide binding]; other site 693974004149 catalytic triad [active] 693974004150 peroxidatic and resolving cysteines [active] 693974004151 Conserved TM helix; Region: TM_helix; pfam05552 693974004152 mechanosensitive channel MscS; Provisional; Region: PRK10334 693974004153 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693974004154 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693974004155 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693974004156 ligand binding site [chemical binding]; other site 693974004157 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 693974004158 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 693974004159 tetramer interface [polypeptide binding]; other site 693974004160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974004161 catalytic residue [active] 693974004162 HDOD domain; Region: HDOD; pfam08668 693974004163 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693974004164 SnoaL-like domain; Region: SnoaL_3; pfam13474 693974004165 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 693974004166 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974004167 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974004168 metal binding site [ion binding]; metal-binding site 693974004169 active site 693974004170 I-site; other site 693974004171 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693974004172 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693974004173 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693974004174 ParA-like protein; Provisional; Region: PHA02518 693974004175 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693974004176 P-loop; other site 693974004177 Magnesium ion binding site [ion binding]; other site 693974004178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693974004179 Coenzyme A binding pocket [chemical binding]; other site 693974004180 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 693974004181 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693974004182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974004183 Coenzyme A binding pocket [chemical binding]; other site 693974004184 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693974004185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974004186 Coenzyme A binding pocket [chemical binding]; other site 693974004187 Pirin-related protein [General function prediction only]; Region: COG1741 693974004188 Pirin; Region: Pirin; pfam02678 693974004189 DoxX; Region: DoxX; pfam07681 693974004190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974004191 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 693974004192 The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431 693974004193 putative dimerization interface [polypeptide binding]; other site 693974004194 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 693974004195 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693974004196 active site 693974004197 metal binding site [ion binding]; metal-binding site 693974004198 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693974004199 Domain of unknown function DUF21; Region: DUF21; pfam01595 693974004200 FOG: CBS domain [General function prediction only]; Region: COG0517 693974004201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693974004202 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 693974004203 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974004204 FeS/SAM binding site; other site 693974004205 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 693974004206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974004207 TPR motif; other site 693974004208 binding surface 693974004209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974004210 binding surface 693974004211 TPR motif; other site 693974004212 cytoskeletal protein RodZ; Provisional; Region: PRK10856 693974004213 Helix-turn-helix domain; Region: HTH_25; pfam13413 693974004214 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 693974004215 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 693974004216 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 693974004217 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 693974004218 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 693974004219 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 693974004220 dimer interface [polypeptide binding]; other site 693974004221 motif 1; other site 693974004222 active site 693974004223 motif 2; other site 693974004224 motif 3; other site 693974004225 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 693974004226 anticodon binding site; other site 693974004227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 693974004228 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 693974004229 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 693974004230 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 693974004231 Trp docking motif [polypeptide binding]; other site 693974004232 active site 693974004233 GTP-binding protein Der; Reviewed; Region: PRK00093 693974004234 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 693974004235 G1 box; other site 693974004236 GTP/Mg2+ binding site [chemical binding]; other site 693974004237 Switch I region; other site 693974004238 G2 box; other site 693974004239 Switch II region; other site 693974004240 G3 box; other site 693974004241 G4 box; other site 693974004242 G5 box; other site 693974004243 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 693974004244 G1 box; other site 693974004245 GTP/Mg2+ binding site [chemical binding]; other site 693974004246 Switch I region; other site 693974004247 G2 box; other site 693974004248 G3 box; other site 693974004249 Switch II region; other site 693974004250 G4 box; other site 693974004251 G5 box; other site 693974004252 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 693974004253 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 693974004254 generic binding surface II; other site 693974004255 generic binding surface I; other site 693974004256 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 693974004257 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 693974004258 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 693974004259 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 693974004260 active site 693974004261 GMP synthase; Reviewed; Region: guaA; PRK00074 693974004262 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 693974004263 AMP/PPi binding site [chemical binding]; other site 693974004264 candidate oxyanion hole; other site 693974004265 catalytic triad [active] 693974004266 potential glutamine specificity residues [chemical binding]; other site 693974004267 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 693974004268 ATP Binding subdomain [chemical binding]; other site 693974004269 Ligand Binding sites [chemical binding]; other site 693974004270 Dimerization subdomain; other site 693974004271 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 693974004272 nucleoside/Zn binding site; other site 693974004273 dimer interface [polypeptide binding]; other site 693974004274 catalytic motif [active] 693974004275 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 693974004276 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974004277 substrate binding pocket [chemical binding]; other site 693974004278 membrane-bound complex binding site; other site 693974004279 hinge residues; other site 693974004280 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693974004281 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693974004282 catalytic residue [active] 693974004283 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 693974004284 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 693974004285 dimerization interface [polypeptide binding]; other site 693974004286 ATP binding site [chemical binding]; other site 693974004287 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 693974004288 dimerization interface [polypeptide binding]; other site 693974004289 ATP binding site [chemical binding]; other site 693974004290 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 693974004291 putative active site [active] 693974004292 catalytic triad [active] 693974004293 Integrase core domain; Region: rve; pfam00665 693974004294 Integrase core domain; Region: rve_3; pfam13683 693974004295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693974004296 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 693974004297 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 693974004298 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 693974004299 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 693974004300 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 693974004301 Cache domain; Region: Cache_1; pfam02743 693974004302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974004303 dimerization interface [polypeptide binding]; other site 693974004304 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974004305 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974004306 dimer interface [polypeptide binding]; other site 693974004307 putative CheW interface [polypeptide binding]; other site 693974004308 Protein of unknown function (DUF465); Region: DUF465; pfam04325 693974004309 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693974004310 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693974004311 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974004312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693974004313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974004314 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 693974004315 Protein of unknown function (DUF2947); Region: DUF2947; pfam11163 693974004316 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 693974004317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693974004318 binding surface 693974004319 TPR motif; other site 693974004320 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 693974004321 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 693974004322 NAD(P) binding site [chemical binding]; other site 693974004323 homodimer interface [polypeptide binding]; other site 693974004324 substrate binding site [chemical binding]; other site 693974004325 active site 693974004326 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 693974004327 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693974004328 inhibitor-cofactor binding pocket; inhibition site 693974004329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974004330 catalytic residue [active] 693974004331 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693974004332 active site 693974004333 N-terminal catalytic domain of alpha-galactosidase; glycoside hydrolase family 57 (GH57); Region: GH57N_PfGalA_like; cd10794 693974004334 putative active site [active] 693974004335 catalytic site [active] 693974004336 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693974004337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974004338 S-adenosylmethionine binding site [chemical binding]; other site 693974004339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 693974004340 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693974004341 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693974004342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974004343 S-adenosylmethionine binding site [chemical binding]; other site 693974004344 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 693974004345 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 693974004346 TPP-binding site; other site 693974004347 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693974004348 PYR/PP interface [polypeptide binding]; other site 693974004349 dimer interface [polypeptide binding]; other site 693974004350 TPP binding site [chemical binding]; other site 693974004351 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693974004352 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693974004353 classical (c) SDRs; Region: SDR_c; cd05233 693974004354 NAD(P) binding site [chemical binding]; other site 693974004355 active site 693974004356 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693974004357 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 693974004358 NeuB family; Region: NeuB; pfam03102 693974004359 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 693974004360 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693974004361 integrase; Provisional; Region: int; PHA02601 693974004362 active site 693974004363 DNA binding site [nucleotide binding] 693974004364 Int/Topo IB signature motif; other site 693974004365 HsdM N-terminal domain; Region: HsdM_N; pfam12161 693974004366 Methyltransferase domain; Region: Methyltransf_26; pfam13659 693974004367 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693974004368 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 693974004369 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693974004370 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 693974004371 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693974004372 ATP binding site [chemical binding]; other site 693974004373 putative Mg++ binding site [ion binding]; other site 693974004374 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974004375 nucleotide binding region [chemical binding]; other site 693974004376 ATP-binding site [chemical binding]; other site 693974004377 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 693974004378 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 693974004379 Helix-turn-helix domain; Region: HTH_17; pfam12728 693974004380 LPP20 lipoprotein; Region: LPP20; pfam02169 693974004381 FlgN protein; Region: FlgN; pfam05130 693974004382 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 693974004383 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 693974004384 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 693974004385 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 693974004386 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974004387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974004388 active site 693974004389 phosphorylation site [posttranslational modification] 693974004390 intermolecular recognition site; other site 693974004391 dimerization interface [polypeptide binding]; other site 693974004392 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 693974004393 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 693974004394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974004395 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12625 693974004396 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 693974004397 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631 693974004398 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693974004399 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693974004400 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 693974004401 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 693974004402 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 693974004403 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 693974004404 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 693974004405 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693974004406 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 693974004407 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 693974004408 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 693974004409 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693974004410 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693974004411 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 693974004412 Flagellar L-ring protein; Region: FlgH; pfam02107 693974004413 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 693974004414 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 693974004415 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 693974004416 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 693974004417 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 693974004418 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08871 693974004419 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693974004420 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693974004421 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 693974004422 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693974004423 flagellin; Provisional; Region: PRK12802 693974004424 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693974004425 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693974004426 flagellin; Provisional; Region: PRK12802 693974004427 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693974004428 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693974004429 FlaG protein; Region: FlaG; pfam03646 693974004430 flagellar capping protein; Reviewed; Region: fliD; PRK08032 693974004431 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 693974004432 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 693974004433 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 693974004434 flagellar protein FliS; Validated; Region: fliS; PRK05685 693974004435 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 693974004436 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 693974004437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974004438 Walker A motif; other site 693974004439 ATP binding site [chemical binding]; other site 693974004440 Walker B motif; other site 693974004441 arginine finger; other site 693974004442 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693974004443 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693974004444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974004445 putative active site [active] 693974004446 heme pocket [chemical binding]; other site 693974004447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974004448 dimer interface [polypeptide binding]; other site 693974004449 phosphorylation site [posttranslational modification] 693974004450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974004451 ATP binding site [chemical binding]; other site 693974004452 Mg2+ binding site [ion binding]; other site 693974004453 G-X-G motif; other site 693974004454 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693974004455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974004456 active site 693974004457 phosphorylation site [posttranslational modification] 693974004458 intermolecular recognition site; other site 693974004459 dimerization interface [polypeptide binding]; other site 693974004460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974004461 Walker A motif; other site 693974004462 ATP binding site [chemical binding]; other site 693974004463 Walker B motif; other site 693974004464 arginine finger; other site 693974004465 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693974004466 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 693974004467 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 693974004468 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 693974004469 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 693974004470 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 693974004471 MgtE intracellular N domain; Region: MgtE_N; smart00924 693974004472 FliG C-terminal domain; Region: FliG_C; pfam01706 693974004473 flagellar assembly protein H; Validated; Region: fliH; PRK05687 693974004474 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 693974004475 Flagellar assembly protein FliH; Region: FliH; pfam02108 693974004476 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972 693974004477 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 693974004478 Walker A motif/ATP binding site; other site 693974004479 Walker B motif; other site 693974004480 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 693974004481 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 693974004482 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 693974004483 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 693974004484 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 693974004485 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 693974004486 flagellar motor switch protein; Validated; Region: fliN; PRK08983 693974004487 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 693974004488 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 693974004489 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 693974004490 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 693974004491 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 693974004492 flhB C-terminus-related protein; Region: flhB_rel; TIGR00789 693974004493 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 693974004494 FHIPEP family; Region: FHIPEP; pfam00771 693974004495 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 693974004496 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693974004497 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693974004498 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 693974004499 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 693974004500 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 693974004501 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693974004502 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693974004503 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693974004504 DNA binding residues [nucleotide binding] 693974004505 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 693974004506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974004507 active site 693974004508 phosphorylation site [posttranslational modification] 693974004509 intermolecular recognition site; other site 693974004510 dimerization interface [polypeptide binding]; other site 693974004511 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 693974004512 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693974004513 putative binding surface; other site 693974004514 active site 693974004515 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 693974004516 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 693974004517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974004518 ATP binding site [chemical binding]; other site 693974004519 Mg2+ binding site [ion binding]; other site 693974004520 G-X-G motif; other site 693974004521 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 693974004522 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 693974004523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974004524 active site 693974004525 phosphorylation site [posttranslational modification] 693974004526 intermolecular recognition site; other site 693974004527 CheB methylesterase; Region: CheB_methylest; pfam01339 693974004528 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693974004529 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693974004530 P-loop; other site 693974004531 Magnesium ion binding site [ion binding]; other site 693974004532 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693974004533 Magnesium ion binding site [ion binding]; other site 693974004534 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 693974004535 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 693974004536 putative CheA interaction surface; other site 693974004537 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 693974004538 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 693974004539 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 693974004540 VacJ like lipoprotein; Region: VacJ; cl01073 693974004541 Response regulator receiver domain; Region: Response_reg; pfam00072 693974004542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974004543 active site 693974004544 phosphorylation site [posttranslational modification] 693974004545 intermolecular recognition site; other site 693974004546 dimerization interface [polypeptide binding]; other site 693974004547 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 693974004548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974004549 putative substrate translocation pore; other site 693974004550 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 693974004551 transcriptional activator RfaH; Region: RfaH; TIGR01955 693974004552 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 693974004553 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 693974004554 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 693974004555 SLBB domain; Region: SLBB; pfam10531 693974004556 SLBB domain; Region: SLBB; pfam10531 693974004557 SLBB domain; Region: SLBB; pfam10531 693974004558 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 693974004559 SLBB domain; Region: SLBB; pfam10531 693974004560 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 693974004561 Chain length determinant protein; Region: Wzz; pfam02706 693974004562 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 693974004563 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 693974004564 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 693974004565 NAD binding site [chemical binding]; other site 693974004566 substrate binding site [chemical binding]; other site 693974004567 homodimer interface [polypeptide binding]; other site 693974004568 active site 693974004569 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 693974004570 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 693974004571 substrate binding site; other site 693974004572 tetramer interface; other site 693974004573 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 693974004574 extended (e) SDRs; Region: SDR_e; cd08946 693974004575 NAD(P) binding site [chemical binding]; other site 693974004576 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693974004577 active site 693974004578 substrate binding site [chemical binding]; other site 693974004579 putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677 693974004580 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 693974004581 trimer interface [polypeptide binding]; other site 693974004582 active site 693974004583 substrate binding site [chemical binding]; other site 693974004584 CoA binding site [chemical binding]; other site 693974004585 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 693974004586 trimer interface [polypeptide binding]; other site 693974004587 active site 693974004588 substrate binding site [chemical binding]; other site 693974004589 CoA binding site [chemical binding]; other site 693974004590 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 693974004591 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 693974004592 Probable Catalytic site; other site 693974004593 metal-binding site 693974004594 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693974004595 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693974004596 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 693974004597 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 693974004598 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 693974004599 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693974004600 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 693974004601 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 693974004602 dimer interface [polypeptide binding]; other site 693974004603 active site 693974004604 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 693974004605 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 693974004606 Substrate binding site; other site 693974004607 Mg++ binding site; other site 693974004608 metal-binding site 693974004609 Mg++ binding site; other site 693974004610 metal-binding site 693974004611 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 693974004612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974004613 active site 693974004614 motif I; other site 693974004615 motif II; other site 693974004616 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 693974004617 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 693974004618 Mg++ binding site [ion binding]; other site 693974004619 putative catalytic motif [active] 693974004620 substrate binding site [chemical binding]; other site 693974004621 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 693974004622 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 693974004623 active site 693974004624 substrate binding site [chemical binding]; other site 693974004625 metal binding site [ion binding]; metal-binding site 693974004626 HutD; Region: HutD; pfam05962 693974004627 NlpE N-terminal domain; Region: NlpE; pfam04170 693974004628 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974004629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 693974004630 active site 693974004631 phosphorylation site [posttranslational modification] 693974004632 intermolecular recognition site; other site 693974004633 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 693974004634 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 693974004635 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693974004636 Zn2+ binding site [ion binding]; other site 693974004637 Mg2+ binding site [ion binding]; other site 693974004638 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693974004639 GAF domain; Region: GAF; pfam01590 693974004640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693974004641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974004642 ATP binding site [chemical binding]; other site 693974004643 Mg2+ binding site [ion binding]; other site 693974004644 G-X-G motif; other site 693974004645 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 693974004646 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 693974004647 substrate binding site; other site 693974004648 tetramer interface; other site 693974004649 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 693974004650 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693974004651 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 693974004652 active site 693974004653 FMN binding site [chemical binding]; other site 693974004654 substrate binding site [chemical binding]; other site 693974004655 homotetramer interface [polypeptide binding]; other site 693974004656 catalytic residue [active] 693974004657 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 693974004658 MltA-interacting protein MipA; Region: MipA; cl01504 693974004659 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 693974004660 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 693974004661 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 693974004662 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 693974004663 nucleophile elbow; other site 693974004664 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 693974004665 active site 693974004666 oligomerization interface [polypeptide binding]; other site 693974004667 metal binding site [ion binding]; metal-binding site 693974004668 Cupin domain; Region: Cupin_2; cl17218 693974004669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974004670 Helix-turn-helix domain; Region: HTH_18; pfam12833 693974004671 prolyl-tRNA synthetase; Provisional; Region: PRK09194 693974004672 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 693974004673 dimer interface [polypeptide binding]; other site 693974004674 motif 1; other site 693974004675 active site 693974004676 motif 2; other site 693974004677 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 693974004678 putative deacylase active site [active] 693974004679 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693974004680 active site 693974004681 motif 3; other site 693974004682 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 693974004683 anticodon binding site; other site 693974004684 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 693974004685 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693974004686 putative CoA binding site [chemical binding]; other site 693974004687 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 693974004688 trimer interface [polypeptide binding]; other site 693974004689 active site 693974004690 substrate binding site [chemical binding]; other site 693974004691 CoA binding site [chemical binding]; other site 693974004692 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 693974004693 homodimer interaction site [polypeptide binding]; other site 693974004694 cofactor binding site; other site 693974004695 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 693974004696 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 693974004697 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 693974004698 active site 693974004699 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693974004700 active site 693974004701 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 693974004702 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 693974004703 active site 693974004704 H-NS histone family; Region: Histone_HNS; pfam00816 693974004705 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 693974004706 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 693974004707 Ligand binding site [chemical binding]; other site 693974004708 Electron transfer flavoprotein domain; Region: ETF; pfam01012 693974004709 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 693974004710 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 693974004711 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693974004712 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 693974004713 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 693974004714 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693974004715 active site 693974004716 Zn binding site [ion binding]; other site 693974004717 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 693974004718 thymidine kinase; Provisional; Region: PRK04296 693974004719 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 693974004720 Transglycosylase; Region: Transgly; cl17702 693974004721 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 693974004722 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 693974004723 hypothetical protein; Provisional; Region: PRK10621 693974004724 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693974004725 Putative amidotransferase; Region: DUF4066; pfam13278 693974004726 conserved cys residue [active] 693974004727 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 693974004728 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 693974004729 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 693974004730 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 693974004731 active site 693974004732 catalytic residues [active] 693974004733 metal binding site [ion binding]; metal-binding site 693974004734 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 693974004735 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693974004736 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693974004737 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693974004738 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693974004739 carboxyltransferase (CT) interaction site; other site 693974004740 biotinylation site [posttranslational modification]; other site 693974004741 enoyl-CoA hydratase; Provisional; Region: PRK05995 693974004742 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693974004743 substrate binding site [chemical binding]; other site 693974004744 oxyanion hole (OAH) forming residues; other site 693974004745 trimer interface [polypeptide binding]; other site 693974004746 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 693974004747 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 693974004748 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 693974004749 isovaleryl-CoA dehydrogenase; Region: PLN02519 693974004750 substrate binding site [chemical binding]; other site 693974004751 FAD binding site [chemical binding]; other site 693974004752 catalytic base [active] 693974004753 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693974004754 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 693974004755 DNA binding residues [nucleotide binding] 693974004756 putative dimer interface [polypeptide binding]; other site 693974004757 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 693974004758 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693974004759 acyl-activating enzyme (AAE) consensus motif; other site 693974004760 AMP binding site [chemical binding]; other site 693974004761 active site 693974004762 CoA binding site [chemical binding]; other site 693974004763 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 693974004764 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693974004765 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 693974004766 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 693974004767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974004768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974004769 LysR substrate binding domain; Region: LysR_substrate; pfam03466 693974004770 dimerization interface [polypeptide binding]; other site 693974004771 DoxX-like family; Region: DoxX_2; pfam13564 693974004772 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 693974004773 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 693974004774 putative active site [active] 693974004775 metal binding site [ion binding]; metal-binding site 693974004776 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 693974004777 UbiA prenyltransferase family; Region: UbiA; pfam01040 693974004778 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 693974004779 classical (c) SDRs; Region: SDR_c; cd05233 693974004780 NAD(P) binding site [chemical binding]; other site 693974004781 active site 693974004782 acyl-CoA thioesterase II; Provisional; Region: PRK10526 693974004783 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 693974004784 active site 693974004785 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 693974004786 catalytic triad [active] 693974004787 dimer interface [polypeptide binding]; other site 693974004788 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 693974004789 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 693974004790 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 693974004791 active site 693974004792 catalytic triad [active] 693974004793 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 693974004794 PA/protease or protease-like domain interface [polypeptide binding]; other site 693974004795 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693974004796 catalytic residues [active] 693974004797 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693974004798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974004799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974004800 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693974004801 dimerization interface [polypeptide binding]; other site 693974004802 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693974004803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974004804 putative substrate translocation pore; other site 693974004805 Integrase core domain; Region: rve; pfam00665 693974004806 Integrase core domain; Region: rve_3; pfam13683 693974004807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693974004808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974004809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974004810 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974004811 putative effector binding pocket; other site 693974004812 dimerization interface [polypeptide binding]; other site 693974004813 Protein of unknown function, DUF606; Region: DUF606; pfam04657 693974004814 Protein of unknown function, DUF606; Region: DUF606; pfam04657 693974004815 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693974004816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974004817 active site 693974004818 phosphorylation site [posttranslational modification] 693974004819 intermolecular recognition site; other site 693974004820 dimerization interface [polypeptide binding]; other site 693974004821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974004822 Walker A motif; other site 693974004823 ATP binding site [chemical binding]; other site 693974004824 Walker B motif; other site 693974004825 arginine finger; other site 693974004826 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693974004827 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 693974004828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974004829 dimer interface [polypeptide binding]; other site 693974004830 phosphorylation site [posttranslational modification] 693974004831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974004832 ATP binding site [chemical binding]; other site 693974004833 Mg2+ binding site [ion binding]; other site 693974004834 G-X-G motif; other site 693974004835 DctM-like transporters; Region: DctM; pfam06808 693974004836 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693974004837 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693974004838 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693974004839 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 693974004840 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 693974004841 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 693974004842 active site 693974004843 HIGH motif; other site 693974004844 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 693974004845 active site 693974004846 KMSKS motif; other site 693974004847 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693974004848 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693974004849 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 693974004850 Walker A/P-loop; other site 693974004851 ATP binding site [chemical binding]; other site 693974004852 Q-loop/lid; other site 693974004853 ABC transporter signature motif; other site 693974004854 Walker B; other site 693974004855 D-loop; other site 693974004856 H-loop/switch region; other site 693974004857 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 693974004858 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 693974004859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974004860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974004861 AlkA N-terminal domain; Region: AlkA_N; pfam06029 693974004862 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 693974004863 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693974004864 minor groove reading motif; other site 693974004865 helix-hairpin-helix signature motif; other site 693974004866 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693974004867 DNA binding site [nucleotide binding] 693974004868 active site 693974004869 helicase 45; Provisional; Region: PTZ00424 693974004870 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693974004871 ATP binding site [chemical binding]; other site 693974004872 Mg++ binding site [ion binding]; other site 693974004873 motif III; other site 693974004874 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974004875 nucleotide binding region [chemical binding]; other site 693974004876 ATP-binding site [chemical binding]; other site 693974004877 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 693974004878 active site 693974004879 catalytic residues [active] 693974004880 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 693974004881 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974004882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974004883 active site 693974004884 phosphorylation site [posttranslational modification] 693974004885 intermolecular recognition site; other site 693974004886 dimerization interface [polypeptide binding]; other site 693974004887 serine/threonine transporter SstT; Provisional; Region: PRK13628 693974004888 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693974004889 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 693974004890 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693974004891 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693974004892 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693974004893 active site 693974004894 Protein of unknown function, DUF479; Region: DUF479; pfam04336 693974004895 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 693974004896 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 693974004897 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 693974004898 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 693974004899 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 693974004900 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 693974004901 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 693974004902 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 693974004903 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 693974004904 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 693974004905 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 693974004906 Protein export membrane protein; Region: SecD_SecF; pfam02355 693974004907 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 693974004908 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693974004909 active site residue [active] 693974004910 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 693974004911 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 693974004912 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 693974004913 YaeQ protein; Region: YaeQ; pfam07152 693974004914 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 693974004915 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 693974004916 active site 693974004917 catalytic residues [active] 693974004918 PA_VapT_like: Protease-associated domain containing proteins like VapT from Vibrio metschnikovii strain RH530. This group contains various PA domain-containing proteins similar to V. metschnikovii VapT, including the serine alkaline protease SapSh from...; Region: PA_VapT_like; cd04817 693974004919 PA/subtilisin-like domain interface [polypeptide binding]; other site 693974004920 Subtilase family; Region: Peptidase_S8; pfam00082 693974004921 catalytic residues [active] 693974004922 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693974004923 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 693974004924 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693974004925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974004926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693974004927 Coenzyme A binding pocket [chemical binding]; other site 693974004928 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693974004929 active site residue [active] 693974004930 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 693974004931 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693974004932 Protein export membrane protein; Region: SecD_SecF; cl14618 693974004933 Protein export membrane protein; Region: SecD_SecF; cl14618 693974004934 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693974004935 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974004936 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974004937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 693974004938 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693974004939 active site 693974004940 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 693974004941 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 693974004942 Na binding site [ion binding]; other site 693974004943 Protein of unknown function (DUF3379); Region: DUF3379; pfam11859 693974004944 RNA polymerase sigma factor; Provisional; Region: PRK12517 693974004945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693974004946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693974004947 DNA binding residues [nucleotide binding] 693974004948 Oxygen tolerance; Region: BatD; pfam13584 693974004949 von Willebrand factor type A domain; Region: VWA_2; pfam13519 693974004950 metal ion-dependent adhesion site (MIDAS); other site 693974004951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974004952 binding surface 693974004953 TPR motif; other site 693974004954 Tetratricopeptide repeat; Region: TPR_16; pfam13432 693974004955 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 693974004956 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 693974004957 metal ion-dependent adhesion site (MIDAS); other site 693974004958 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 693974004959 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 693974004960 Protein of unknown function DUF58; Region: DUF58; pfam01882 693974004961 MoxR-like ATPases [General function prediction only]; Region: COG0714 693974004962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974004963 Walker A motif; other site 693974004964 ATP binding site [chemical binding]; other site 693974004965 Walker B motif; other site 693974004966 arginine finger; other site 693974004967 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 693974004968 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693974004969 dimer interface [polypeptide binding]; other site 693974004970 active site 693974004971 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 693974004972 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693974004973 substrate binding site [chemical binding]; other site 693974004974 oxyanion hole (OAH) forming residues; other site 693974004975 trimer interface [polypeptide binding]; other site 693974004976 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693974004977 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693974004978 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693974004979 Two component regulator propeller; Region: Reg_prop; pfam07494 693974004980 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 693974004981 PAS fold; Region: PAS_3; pfam08447 693974004982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974004983 PAS domain; Region: PAS_9; pfam13426 693974004984 putative active site [active] 693974004985 heme pocket [chemical binding]; other site 693974004986 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974004987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974004988 metal binding site [ion binding]; metal-binding site 693974004989 active site 693974004990 I-site; other site 693974004991 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974004992 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 693974004993 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693974004994 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693974004995 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693974004996 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693974004997 catalytic core [active] 693974004998 hypothetical protein; Provisional; Region: PRK04946 693974004999 Smr domain; Region: Smr; pfam01713 693974005000 HemK family putative methylases; Region: hemK_fam; TIGR00536 693974005001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974005002 S-adenosylmethionine binding site [chemical binding]; other site 693974005003 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 693974005004 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 693974005005 Tetramer interface [polypeptide binding]; other site 693974005006 active site 693974005007 FMN-binding site [chemical binding]; other site 693974005008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974005009 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 693974005010 putative substrate translocation pore; other site 693974005011 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 693974005012 YfcL protein; Region: YfcL; pfam08891 693974005013 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 693974005014 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 693974005015 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 693974005016 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 693974005017 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693974005018 dimer interface [polypeptide binding]; other site 693974005019 active site 693974005020 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 693974005021 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 693974005022 ligand binding site [chemical binding]; other site 693974005023 NAD binding site [chemical binding]; other site 693974005024 catalytic site [active] 693974005025 homodimer interface [polypeptide binding]; other site 693974005026 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 693974005027 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693974005028 FimV N-terminal domain; Region: FimV_core; TIGR03505 693974005029 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 693974005030 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 693974005031 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 693974005032 dimerization interface 3.5A [polypeptide binding]; other site 693974005033 active site 693974005034 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 693974005035 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693974005036 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693974005037 Sporulation related domain; Region: SPOR; pfam05036 693974005038 Colicin V production protein; Region: Colicin_V; cl00567 693974005039 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 693974005040 amidophosphoribosyltransferase; Provisional; Region: PRK09246 693974005041 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 693974005042 active site 693974005043 tetramer interface [polypeptide binding]; other site 693974005044 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693974005045 active site 693974005046 DNA topoisomerase III; Provisional; Region: PRK07726 693974005047 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 693974005048 active site 693974005049 putative interdomain interaction site [polypeptide binding]; other site 693974005050 putative metal-binding site [ion binding]; other site 693974005051 putative nucleotide binding site [chemical binding]; other site 693974005052 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693974005053 domain I; other site 693974005054 DNA binding groove [nucleotide binding] 693974005055 phosphate binding site [ion binding]; other site 693974005056 domain II; other site 693974005057 domain III; other site 693974005058 nucleotide binding site [chemical binding]; other site 693974005059 catalytic site [active] 693974005060 domain IV; other site 693974005061 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 693974005062 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693974005063 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974005064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693974005065 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974005066 dimer interface [polypeptide binding]; other site 693974005067 putative CheW interface [polypeptide binding]; other site 693974005068 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 693974005069 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 693974005070 XdhC Rossmann domain; Region: XdhC_C; pfam13478 693974005071 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 693974005072 Ligand binding site; other site 693974005073 metal-binding site 693974005074 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693974005075 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693974005076 catalytic loop [active] 693974005077 iron binding site [ion binding]; other site 693974005078 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693974005079 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693974005080 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693974005081 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693974005082 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693974005083 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693974005084 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 693974005085 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693974005086 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974005087 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974005088 dimer interface [polypeptide binding]; other site 693974005089 putative CheW interface [polypeptide binding]; other site 693974005090 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 693974005091 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693974005092 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693974005093 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693974005094 ligand binding site [chemical binding]; other site 693974005095 flexible hinge region; other site 693974005096 non-specific DNA interactions [nucleotide binding]; other site 693974005097 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 693974005098 DNA binding site [nucleotide binding] 693974005099 sequence specific DNA binding site [nucleotide binding]; other site 693974005100 putative cAMP binding site [chemical binding]; other site 693974005101 PRC-barrel domain; Region: PRC; pfam05239 693974005102 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 693974005103 putative catalytic site [active] 693974005104 putative phosphate binding site [ion binding]; other site 693974005105 active site 693974005106 metal binding site A [ion binding]; metal-binding site 693974005107 DNA binding site [nucleotide binding] 693974005108 putative AP binding site [nucleotide binding]; other site 693974005109 putative metal binding site B [ion binding]; other site 693974005110 YciI-like protein; Reviewed; Region: PRK11370 693974005111 intracellular septation protein A; Reviewed; Region: PRK00259 693974005112 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 693974005113 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 693974005114 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 693974005115 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 693974005116 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974005117 N-terminal plug; other site 693974005118 ligand-binding site [chemical binding]; other site 693974005119 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 693974005120 IucA / IucC family; Region: IucA_IucC; pfam04183 693974005121 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 693974005122 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 693974005123 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 693974005124 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 693974005125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693974005126 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 693974005127 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 693974005128 substrate binding site [chemical binding]; other site 693974005129 active site 693974005130 catalytic residues [active] 693974005131 heterodimer interface [polypeptide binding]; other site 693974005132 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 693974005133 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 693974005134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974005135 catalytic residue [active] 693974005136 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 693974005137 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 693974005138 active site 693974005139 ribulose/triose binding site [chemical binding]; other site 693974005140 phosphate binding site [ion binding]; other site 693974005141 substrate (anthranilate) binding pocket [chemical binding]; other site 693974005142 product (indole) binding pocket [chemical binding]; other site 693974005143 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 693974005144 active site 693974005145 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 693974005146 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693974005147 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693974005148 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 693974005149 glutamine binding [chemical binding]; other site 693974005150 catalytic triad [active] 693974005151 anthranilate synthase component I; Provisional; Region: PRK13564 693974005152 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 693974005153 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 693974005154 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 693974005155 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 693974005156 active site 693974005157 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 693974005158 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 693974005159 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 693974005160 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 693974005161 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 693974005162 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693974005163 RNA binding surface [nucleotide binding]; other site 693974005164 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 693974005165 probable active site [active] 693974005166 BNR repeat-like domain; Region: BNR_2; pfam13088 693974005167 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 693974005168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974005169 NAD(P) binding site [chemical binding]; other site 693974005170 active site 693974005171 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 693974005172 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 693974005173 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 693974005174 putative inner membrane peptidase; Provisional; Region: PRK11778 693974005175 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 693974005176 tandem repeat interface [polypeptide binding]; other site 693974005177 oligomer interface [polypeptide binding]; other site 693974005178 active site residues [active] 693974005179 Predicted integral membrane protein [Function unknown]; Region: COG0392 693974005180 Uncharacterized conserved protein [Function unknown]; Region: COG2898 693974005181 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 693974005182 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 693974005183 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693974005184 Protein of unknown function (DUF3083); Region: DUF3083; pfam11281 693974005185 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 693974005186 active site 693974005187 catalytic triad [active] 693974005188 oxyanion hole [active] 693974005189 switch loop; other site 693974005190 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 693974005191 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693974005192 Walker A/P-loop; other site 693974005193 ATP binding site [chemical binding]; other site 693974005194 Q-loop/lid; other site 693974005195 ABC transporter signature motif; other site 693974005196 Walker B; other site 693974005197 D-loop; other site 693974005198 H-loop/switch region; other site 693974005199 FtsX-like permease family; Region: FtsX; pfam02687 693974005200 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 693974005201 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693974005202 Catalytic site [active] 693974005203 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693974005204 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 693974005205 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 693974005206 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 693974005207 putative NAD(P) binding site [chemical binding]; other site 693974005208 putative active site [active] 693974005209 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245 693974005210 active site 693974005211 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 693974005212 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693974005213 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 693974005214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974005215 S-adenosylmethionine binding site [chemical binding]; other site 693974005216 phosphate acetyltransferase; Reviewed; Region: PRK05632 693974005217 DRTGG domain; Region: DRTGG; pfam07085 693974005218 phosphate acetyltransferase; Region: pta; TIGR00651 693974005219 propionate/acetate kinase; Provisional; Region: PRK12379 693974005220 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693974005221 nucleotide binding site [chemical binding]; other site 693974005222 butyrate kinase; Provisional; Region: PRK03011 693974005223 Protein of unknown function, DUF412; Region: DUF412; pfam04217 693974005224 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 693974005225 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974005226 FeS/SAM binding site; other site 693974005227 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 693974005228 Pyruvate formate lyase 1; Region: PFL1; cd01678 693974005229 coenzyme A binding site [chemical binding]; other site 693974005230 active site 693974005231 catalytic residues [active] 693974005232 glycine loop; other site 693974005233 formate transporter FocA; Region: formate_focA; TIGR04060 693974005234 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974005235 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974005236 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974005237 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 693974005238 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 693974005239 gating phenylalanine in ion channel; other site 693974005240 Methyltransferase domain; Region: Methyltransf_18; pfam12847 693974005241 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 693974005242 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693974005243 dimer interface [polypeptide binding]; other site 693974005244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974005245 catalytic residue [active] 693974005246 RDD family; Region: RDD; pfam06271 693974005247 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 693974005248 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 693974005249 active site 693974005250 putative sulfate transport protein CysZ; Validated; Region: PRK04949 693974005251 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 693974005252 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 693974005253 Walker A/P-loop; other site 693974005254 ATP binding site [chemical binding]; other site 693974005255 Q-loop/lid; other site 693974005256 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 693974005257 ABC transporter signature motif; other site 693974005258 Walker B; other site 693974005259 D-loop; other site 693974005260 H-loop/switch region; other site 693974005261 cell division protein ZipA; Provisional; Region: PRK03427 693974005262 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 693974005263 FtsZ protein binding site [polypeptide binding]; other site 693974005264 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 693974005265 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 693974005266 nucleotide binding pocket [chemical binding]; other site 693974005267 K-X-D-G motif; other site 693974005268 catalytic site [active] 693974005269 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 693974005270 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 693974005271 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 693974005272 Dimer interface [polypeptide binding]; other site 693974005273 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 693974005274 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 693974005275 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693974005276 Zn2+ binding site [ion binding]; other site 693974005277 Mg2+ binding site [ion binding]; other site 693974005278 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 693974005279 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693974005280 putative NAD(P) binding site [chemical binding]; other site 693974005281 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 693974005282 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 693974005283 catalytic residues [active] 693974005284 hinge region; other site 693974005285 alpha helical domain; other site 693974005286 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 693974005287 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 693974005288 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 693974005289 Na binding site [ion binding]; other site 693974005290 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 693974005291 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 693974005292 ligand binding site [chemical binding]; other site 693974005293 flexible hinge region; other site 693974005294 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 693974005295 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693974005296 metal binding triad; other site 693974005297 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 693974005298 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 693974005299 active site 693974005300 catalytic site [active] 693974005301 substrate binding site [chemical binding]; other site 693974005302 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 693974005303 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 693974005304 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 693974005305 dimer interface [polypeptide binding]; other site 693974005306 active site 693974005307 CoA binding pocket [chemical binding]; other site 693974005308 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693974005309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693974005310 DNA-binding site [nucleotide binding]; DNA binding site 693974005311 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693974005312 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 693974005313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974005314 active site 693974005315 motif I; other site 693974005316 motif II; other site 693974005317 hypothetical protein; Provisional; Region: PRK03641 693974005318 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 693974005319 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 693974005320 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 693974005321 active site 693974005322 metal binding site [ion binding]; metal-binding site 693974005323 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693974005324 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 693974005325 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693974005326 active site 693974005327 Zn binding site [ion binding]; other site 693974005328 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693974005329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974005330 Coenzyme A binding pocket [chemical binding]; other site 693974005331 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 693974005332 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693974005333 active site 693974005334 Zn binding site [ion binding]; other site 693974005335 hypothetical protein; Provisional; Region: PRK06156 693974005336 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 693974005337 active site 693974005338 metal binding site [ion binding]; metal-binding site 693974005339 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 693974005340 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 693974005341 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 693974005342 Protein of unknown function, DUF482; Region: DUF482; pfam04339 693974005343 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693974005344 maltose O-acetyltransferase; Provisional; Region: PRK10092 693974005345 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 693974005346 active site 693974005347 substrate binding site [chemical binding]; other site 693974005348 trimer interface [polypeptide binding]; other site 693974005349 CoA binding site [chemical binding]; other site 693974005350 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 693974005351 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 693974005352 dimer interface [polypeptide binding]; other site 693974005353 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 693974005354 active site 693974005355 Fe binding site [ion binding]; other site 693974005356 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 693974005357 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974005358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974005359 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693974005360 dimerization interface [polypeptide binding]; other site 693974005361 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 693974005362 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 693974005363 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693974005364 Uncharacterized conserved protein [Function unknown]; Region: COG2947 693974005365 AMP-binding domain protein; Validated; Region: PRK08315 693974005366 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693974005367 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 693974005368 acyl-activating enzyme (AAE) consensus motif; other site 693974005369 putative AMP binding site [chemical binding]; other site 693974005370 putative active site [active] 693974005371 putative CoA binding site [chemical binding]; other site 693974005372 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974005373 membrane-bound complex binding site; other site 693974005374 hinge residues; other site 693974005375 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 693974005376 putative active site [active] 693974005377 Zn binding site [ion binding]; other site 693974005378 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693974005379 hypothetical protein; Provisional; Region: PRK11770 693974005380 Domain of unknown function (DUF307); Region: DUF307; pfam03733 693974005381 Domain of unknown function (DUF307); Region: DUF307; pfam03733 693974005382 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 693974005383 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 693974005384 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 693974005385 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 693974005386 RNA polymerase sigma factor; Provisional; Region: PRK11924 693974005387 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693974005388 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693974005389 DNA binding residues [nucleotide binding] 693974005390 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 693974005391 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693974005392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974005393 S-adenosylmethionine binding site [chemical binding]; other site 693974005394 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 693974005395 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974005396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974005397 active site 693974005398 phosphorylation site [posttranslational modification] 693974005399 intermolecular recognition site; other site 693974005400 dimerization interface [polypeptide binding]; other site 693974005401 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 693974005402 Transglycosylase SLT domain; Region: SLT_2; pfam13406 693974005403 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693974005404 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693974005405 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693974005406 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 693974005407 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693974005408 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 693974005409 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 693974005410 active site 693974005411 Zn binding site [ion binding]; other site 693974005412 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 693974005413 Protein of unknown function (DUF3389); Region: DUF3389; pfam11869 693974005414 putative hydrolase; Provisional; Region: PRK11460 693974005415 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 693974005416 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 693974005417 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 693974005418 active site 693974005419 metal binding site [ion binding]; metal-binding site 693974005420 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693974005421 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 693974005422 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 693974005423 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693974005424 FMN binding site [chemical binding]; other site 693974005425 active site 693974005426 catalytic residues [active] 693974005427 substrate binding site [chemical binding]; other site 693974005428 hypothetical protein; Provisional; Region: PRK05409 693974005429 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 693974005430 hypothetical protein; Provisional; Region: PRK10527 693974005431 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693974005432 active site 693974005433 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949 693974005434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974005435 Walker A motif; other site 693974005436 ATP binding site [chemical binding]; other site 693974005437 Walker B motif; other site 693974005438 arginine finger; other site 693974005439 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 693974005440 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 693974005441 hypothetical protein; Validated; Region: PRK00153 693974005442 recombination protein RecR; Reviewed; Region: recR; PRK00076 693974005443 RecR protein; Region: RecR; pfam02132 693974005444 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 693974005445 putative active site [active] 693974005446 putative metal-binding site [ion binding]; other site 693974005447 tetramer interface [polypeptide binding]; other site 693974005448 putative acetyltransferase YhhY; Provisional; Region: PRK10140 693974005449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974005450 Coenzyme A binding pocket [chemical binding]; other site 693974005451 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 693974005452 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 693974005453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974005454 S-adenosylmethionine binding site [chemical binding]; other site 693974005455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974005456 S-adenosylmethionine binding site [chemical binding]; other site 693974005457 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 693974005458 ABC transporter ATPase component; Reviewed; Region: PRK11147 693974005459 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974005460 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974005461 ABC transporter; Region: ABC_tran_2; pfam12848 693974005462 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974005463 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 693974005464 ribosome modulation factor; Provisional; Region: PRK14563 693974005465 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 693974005466 active site 1 [active] 693974005467 dimer interface [polypeptide binding]; other site 693974005468 active site 2 [active] 693974005469 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 693974005470 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693974005471 Cache domain; Region: Cache_1; pfam02743 693974005472 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693974005473 dimerization interface [polypeptide binding]; other site 693974005474 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974005475 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974005476 dimer interface [polypeptide binding]; other site 693974005477 putative CheW interface [polypeptide binding]; other site 693974005478 response regulator; Provisional; Region: PRK09483 693974005479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974005480 active site 693974005481 phosphorylation site [posttranslational modification] 693974005482 intermolecular recognition site; other site 693974005483 dimerization interface [polypeptide binding]; other site 693974005484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693974005485 DNA binding residues [nucleotide binding] 693974005486 dimerization interface [polypeptide binding]; other site 693974005487 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 693974005488 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 693974005489 GIY-YIG motif/motif A; other site 693974005490 active site 693974005491 catalytic site [active] 693974005492 putative DNA binding site [nucleotide binding]; other site 693974005493 metal binding site [ion binding]; metal-binding site 693974005494 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 693974005495 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 693974005496 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 693974005497 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 693974005498 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 693974005499 active site pocket [active] 693974005500 oxyanion hole [active] 693974005501 catalytic triad [active] 693974005502 active site nucleophile [active] 693974005503 heat shock protein HtpX; Provisional; Region: PRK05457 693974005504 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 693974005505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974005506 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 693974005507 putative dimerization interface [polypeptide binding]; other site 693974005508 Lysine efflux permease [General function prediction only]; Region: COG1279 693974005509 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 693974005510 catalytic triad [active] 693974005511 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 693974005512 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 693974005513 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693974005514 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 693974005515 dihydrodipicolinate synthase; Region: dapA; TIGR00674 693974005516 dimer interface [polypeptide binding]; other site 693974005517 active site 693974005518 catalytic residue [active] 693974005519 lipoprotein; Provisional; Region: PRK11679 693974005520 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 693974005521 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693974005522 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974005523 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974005524 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693974005525 Protein export membrane protein; Region: SecD_SecF; cl14618 693974005526 heat shock protein 90; Provisional; Region: PRK05218 693974005527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974005528 ATP binding site [chemical binding]; other site 693974005529 Mg2+ binding site [ion binding]; other site 693974005530 G-X-G motif; other site 693974005531 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 693974005532 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 693974005533 adenylate kinase; Reviewed; Region: adk; PRK00279 693974005534 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 693974005535 AMP-binding site [chemical binding]; other site 693974005536 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 693974005537 ferrochelatase; Reviewed; Region: hemH; PRK00035 693974005538 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 693974005539 C-terminal domain interface [polypeptide binding]; other site 693974005540 active site 693974005541 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 693974005542 active site 693974005543 N-terminal domain interface [polypeptide binding]; other site 693974005544 inosine/guanosine kinase; Provisional; Region: PRK15074 693974005545 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693974005546 substrate binding site [chemical binding]; other site 693974005547 ATP binding site [chemical binding]; other site 693974005548 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 693974005549 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 693974005550 homodimer interface [polypeptide binding]; other site 693974005551 NAD binding pocket [chemical binding]; other site 693974005552 ATP binding pocket [chemical binding]; other site 693974005553 Mg binding site [ion binding]; other site 693974005554 active-site loop [active] 693974005555 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693974005556 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693974005557 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974005558 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974005559 metal binding site [ion binding]; metal-binding site 693974005560 active site 693974005561 I-site; other site 693974005562 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693974005563 active site 693974005564 DNA binding site [nucleotide binding] 693974005565 Int/Topo IB signature motif; other site 693974005566 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 693974005567 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 693974005568 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 693974005569 iron binding site [ion binding]; other site 693974005570 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 693974005571 AIPR protein; Region: AIPR; pfam10592 693974005572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974005573 non-specific DNA binding site [nucleotide binding]; other site 693974005574 salt bridge; other site 693974005575 Predicted transcriptional regulator [Transcription]; Region: COG2932 693974005576 sequence-specific DNA binding site [nucleotide binding]; other site 693974005577 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693974005578 Catalytic site [active] 693974005579 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 693974005580 Replication protein P; Region: Phage_lambda_P; pfam06992 693974005581 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693974005582 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693974005583 active site 693974005584 DNA binding site [nucleotide binding] 693974005585 Int/Topo IB signature motif; other site 693974005586 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974005587 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693974005588 non-specific DNA binding site [nucleotide binding]; other site 693974005589 salt bridge; other site 693974005590 sequence-specific DNA binding site [nucleotide binding]; other site 693974005591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974005592 Walker A/P-loop; other site 693974005593 ATP binding site [chemical binding]; other site 693974005594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974005595 AAA domain; Region: AAA_21; pfam13304 693974005596 ABC transporter signature motif; other site 693974005597 Walker B; other site 693974005598 D-loop; other site 693974005599 H-loop/switch region; other site 693974005600 HNH endonuclease; Region: HNH; pfam01844 693974005601 HipA N-terminal domain; Region: Couple_hipA; pfam13657 693974005602 HipA-like N-terminal domain; Region: HipA_N; pfam07805 693974005603 HipA-like C-terminal domain; Region: HipA_C; pfam07804 693974005604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974005605 non-specific DNA binding site [nucleotide binding]; other site 693974005606 salt bridge; other site 693974005607 sequence-specific DNA binding site [nucleotide binding]; other site 693974005608 Protein of unknown function (DUF983); Region: DUF983; cl02211 693974005609 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 693974005610 Ion channel; Region: Ion_trans_2; pfam07885 693974005611 Protein of unknown function (DUF952); Region: DUF952; pfam06108 693974005612 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693974005613 Catalytic site [active] 693974005614 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 693974005615 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 693974005616 active site 693974005617 DNA binding site [nucleotide binding] 693974005618 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 693974005619 Domain of unknown function (DUF955); Region: DUF955; cl01076 693974005620 hypothetical protein; Provisional; Region: PRK02135 693974005621 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974005622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974005623 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693974005624 dimerization interface [polypeptide binding]; other site 693974005625 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693974005626 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 693974005627 active site 693974005628 FMN binding site [chemical binding]; other site 693974005629 substrate binding site [chemical binding]; other site 693974005630 homotetramer interface [polypeptide binding]; other site 693974005631 catalytic residue [active] 693974005632 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 693974005633 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 693974005634 Sulfatase; Region: Sulfatase; cl17466 693974005635 hypothetical protein; Provisional; Region: PRK13689 693974005636 Nucleoid-associated protein [General function prediction only]; Region: COG3081 693974005637 nucleoid-associated protein NdpA; Validated; Region: PRK00378 693974005638 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 693974005639 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 693974005640 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693974005641 Peptidase family M23; Region: Peptidase_M23; pfam01551 693974005642 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 693974005643 putative metal binding site [ion binding]; other site 693974005644 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693974005645 Ion transport protein; Region: Ion_trans; pfam00520 693974005646 Ion channel; Region: Ion_trans_2; pfam07885 693974005647 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693974005648 putative efflux protein, MATE family; Region: matE; TIGR00797 693974005649 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 693974005650 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 693974005651 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693974005652 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693974005653 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693974005654 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974005655 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974005656 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 693974005657 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 693974005658 dimer interface [polypeptide binding]; other site 693974005659 active site 693974005660 citrylCoA binding site [chemical binding]; other site 693974005661 NADH binding [chemical binding]; other site 693974005662 cationic pore residues; other site 693974005663 oxalacetate/citrate binding site [chemical binding]; other site 693974005664 coenzyme A binding site [chemical binding]; other site 693974005665 catalytic triad [active] 693974005666 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 693974005667 Iron-sulfur protein interface; other site 693974005668 proximal quinone binding site [chemical binding]; other site 693974005669 SdhD (CybS) interface [polypeptide binding]; other site 693974005670 proximal heme binding site [chemical binding]; other site 693974005671 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 693974005672 SdhC subunit interface [polypeptide binding]; other site 693974005673 proximal heme binding site [chemical binding]; other site 693974005674 cardiolipin binding site; other site 693974005675 Iron-sulfur protein interface; other site 693974005676 proximal quinone binding site [chemical binding]; other site 693974005677 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 693974005678 L-aspartate oxidase; Provisional; Region: PRK06175 693974005679 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693974005680 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 693974005681 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 693974005682 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 693974005683 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 693974005684 TPP-binding site [chemical binding]; other site 693974005685 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 693974005686 PYR/PP interface [polypeptide binding]; other site 693974005687 dimer interface [polypeptide binding]; other site 693974005688 TPP binding site [chemical binding]; other site 693974005689 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 693974005690 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693974005691 E3 interaction surface; other site 693974005692 lipoyl attachment site [posttranslational modification]; other site 693974005693 e3 binding domain; Region: E3_binding; pfam02817 693974005694 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693974005695 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 693974005696 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 693974005697 CoA-ligase; Region: Ligase_CoA; pfam00549 693974005698 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 693974005699 CoA binding domain; Region: CoA_binding; pfam02629 693974005700 CoA-ligase; Region: Ligase_CoA; pfam00549 693974005701 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 693974005702 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693974005703 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693974005704 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693974005705 ferric uptake regulator; Provisional; Region: fur; PRK09462 693974005706 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693974005707 metal binding site 2 [ion binding]; metal-binding site 693974005708 putative DNA binding helix; other site 693974005709 metal binding site 1 [ion binding]; metal-binding site 693974005710 dimer interface [polypeptide binding]; other site 693974005711 structural Zn2+ binding site [ion binding]; other site 693974005712 NAD-dependent deacetylase; Provisional; Region: PRK00481 693974005713 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 693974005714 NAD+ binding site [chemical binding]; other site 693974005715 substrate binding site [chemical binding]; other site 693974005716 Zn binding site [ion binding]; other site 693974005717 AAA domain; Region: AAA_33; pfam13671 693974005718 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 693974005719 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 693974005720 Cl binding site [ion binding]; other site 693974005721 oligomer interface [polypeptide binding]; other site 693974005722 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 693974005723 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693974005724 Zn2+ binding site [ion binding]; other site 693974005725 Mg2+ binding site [ion binding]; other site 693974005726 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 693974005727 sensor protein PhoQ; Provisional; Region: PRK10815 693974005728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974005729 ATP binding site [chemical binding]; other site 693974005730 Mg2+ binding site [ion binding]; other site 693974005731 G-X-G motif; other site 693974005732 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 693974005733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974005734 active site 693974005735 phosphorylation site [posttranslational modification] 693974005736 intermolecular recognition site; other site 693974005737 dimerization interface [polypeptide binding]; other site 693974005738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974005739 DNA binding site [nucleotide binding] 693974005740 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693974005741 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693974005742 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 693974005743 succinylarginine dihydrolase; Provisional; Region: PRK13281 693974005744 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 693974005745 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 693974005746 active site 693974005747 interdomain interaction site; other site 693974005748 putative metal-binding site [ion binding]; other site 693974005749 nucleotide binding site [chemical binding]; other site 693974005750 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693974005751 domain I; other site 693974005752 DNA binding groove [nucleotide binding] 693974005753 phosphate binding site [ion binding]; other site 693974005754 domain II; other site 693974005755 domain III; other site 693974005756 nucleotide binding site [chemical binding]; other site 693974005757 catalytic site [active] 693974005758 domain IV; other site 693974005759 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693974005760 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693974005761 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 693974005762 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 693974005763 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 693974005764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974005765 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 693974005766 substrate binding site [chemical binding]; other site 693974005767 dimerization interface [polypeptide binding]; other site 693974005768 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693974005769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974005770 active site 693974005771 phosphorylation site [posttranslational modification] 693974005772 intermolecular recognition site; other site 693974005773 dimerization interface [polypeptide binding]; other site 693974005774 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693974005775 DNA binding residues [nucleotide binding] 693974005776 dimerization interface [polypeptide binding]; other site 693974005777 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 693974005778 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 693974005779 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 693974005780 aromatic chitin/cellulose binding site residues [chemical binding]; other site 693974005781 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 693974005782 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 693974005783 active site 693974005784 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 693974005785 Chitinase C; Region: ChiC; pfam06483 693974005786 Cellulose-binding domain, chitinase and related proteins; Region: CBD_like; cd12204 693974005787 aromatic chitin/cellulose binding site residues [chemical binding]; other site 693974005788 ligand binding site [chemical binding]; other site 693974005789 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 693974005790 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693974005791 PEP synthetase regulatory protein; Provisional; Region: PRK05339 693974005792 phosphoenolpyruvate synthase; Validated; Region: PRK06464 693974005793 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 693974005794 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693974005795 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693974005796 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693974005797 FAD binding domain; Region: FAD_binding_4; pfam01565 693974005798 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693974005799 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 693974005800 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 693974005801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693974005802 MarR family; Region: MarR; pfam01047 693974005803 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 693974005804 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 693974005805 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 693974005806 NAD binding site [chemical binding]; other site 693974005807 Phe binding site; other site 693974005808 Cupin superfamily protein; Region: Cupin_4; pfam08007 693974005809 Cupin-like domain; Region: Cupin_8; pfam13621 693974005810 adenylosuccinate lyase; Provisional; Region: PRK09285 693974005811 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 693974005812 tetramer interface [polypeptide binding]; other site 693974005813 active site 693974005814 putative lysogenization regulator; Reviewed; Region: PRK00218 693974005815 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 693974005816 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 693974005817 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 693974005818 nudix motif; other site 693974005819 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 693974005820 pseudouridine synthase; Region: TIGR00093 693974005821 probable active site [active] 693974005822 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 693974005823 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 693974005824 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693974005825 DNA-binding site [nucleotide binding]; DNA binding site 693974005826 RNA-binding motif; other site 693974005827 Uncharacterized conserved protein [Function unknown]; Region: COG2127 693974005828 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 693974005829 Clp amino terminal domain; Region: Clp_N; pfam02861 693974005830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974005831 Walker A motif; other site 693974005832 ATP binding site [chemical binding]; other site 693974005833 Walker B motif; other site 693974005834 arginine finger; other site 693974005835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974005836 Walker A motif; other site 693974005837 ATP binding site [chemical binding]; other site 693974005838 Walker B motif; other site 693974005839 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693974005840 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 693974005841 rRNA binding site [nucleotide binding]; other site 693974005842 predicted 30S ribosome binding site; other site 693974005843 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 693974005844 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 693974005845 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 693974005846 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 693974005847 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 693974005848 Uncharacterized conserved protein [Function unknown]; Region: COG0327 693974005849 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 693974005850 Predicted permeases [General function prediction only]; Region: COG0679 693974005851 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 693974005852 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 693974005853 active site 693974005854 HIGH motif; other site 693974005855 KMSKS motif; other site 693974005856 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 693974005857 tRNA binding surface [nucleotide binding]; other site 693974005858 anticodon binding site; other site 693974005859 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 693974005860 dimer interface [polypeptide binding]; other site 693974005861 putative tRNA-binding site [nucleotide binding]; other site 693974005862 antiporter inner membrane protein; Provisional; Region: PRK11670 693974005863 Domain of unknown function DUF59; Region: DUF59; cl00941 693974005864 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 693974005865 Walker A motif; other site 693974005866 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 693974005867 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 693974005868 Sugar specificity; other site 693974005869 Pyrimidine base specificity; other site 693974005870 ATP-binding site [chemical binding]; other site 693974005871 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693974005872 trimer interface [polypeptide binding]; other site 693974005873 active site 693974005874 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 693974005875 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 693974005876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974005877 catalytic residue [active] 693974005878 YceG-like family; Region: YceG; pfam02618 693974005879 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 693974005880 dimerization interface [polypeptide binding]; other site 693974005881 thymidylate kinase; Validated; Region: tmk; PRK00698 693974005882 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 693974005883 TMP-binding site; other site 693974005884 ATP-binding site [chemical binding]; other site 693974005885 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 693974005886 DNA polymerase III subunit delta'; Validated; Region: PRK08485 693974005887 PilZ domain; Region: PilZ; cl01260 693974005888 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693974005889 active site 693974005890 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 693974005891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974005892 S-adenosylmethionine binding site [chemical binding]; other site 693974005893 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 693974005894 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 693974005895 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 693974005896 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 693974005897 mce related protein; Region: MCE; pfam02470 693974005898 mce related protein; Region: MCE; pfam02470 693974005899 mce related protein; Region: MCE; pfam02470 693974005900 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 693974005901 mce related protein; Region: MCE; pfam02470 693974005902 mce related protein; Region: MCE; pfam02470 693974005903 mce related protein; Region: MCE; pfam02470 693974005904 Paraquat-inducible protein A; Region: PqiA; pfam04403 693974005905 Paraquat-inducible protein A; Region: PqiA; pfam04403 693974005906 YebG protein; Region: YebG; pfam07130 693974005907 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 693974005908 GAF domain; Region: GAF_2; pfam13185 693974005909 ProP expression regulator; Provisional; Region: PRK04950 693974005910 ProQ/FINO family; Region: ProQ; smart00945 693974005911 carboxy-terminal protease; Provisional; Region: PRK11186 693974005912 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 693974005913 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 693974005914 protein binding site [polypeptide binding]; other site 693974005915 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 693974005916 Catalytic dyad [active] 693974005917 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 693974005918 aminopeptidase N; Provisional; Region: pepN; PRK14015 693974005919 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 693974005920 active site 693974005921 Zn binding site [ion binding]; other site 693974005922 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 693974005923 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 693974005924 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 693974005925 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 693974005926 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 693974005927 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 693974005928 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 693974005929 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 693974005930 quinone interaction residues [chemical binding]; other site 693974005931 active site 693974005932 catalytic residues [active] 693974005933 FMN binding site [chemical binding]; other site 693974005934 substrate binding site [chemical binding]; other site 693974005935 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 693974005936 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 693974005937 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 693974005938 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 693974005939 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 693974005940 aromatic amino acid transport protein; Region: araaP; TIGR00837 693974005941 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 693974005942 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 693974005943 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 693974005944 metal binding site [ion binding]; metal-binding site 693974005945 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 693974005946 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 693974005947 substrate binding site [chemical binding]; other site 693974005948 glutamase interaction surface [polypeptide binding]; other site 693974005949 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 693974005950 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 693974005951 catalytic residues [active] 693974005952 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 693974005953 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 693974005954 putative active site [active] 693974005955 oxyanion strand; other site 693974005956 catalytic triad [active] 693974005957 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 693974005958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974005959 active site 693974005960 motif I; other site 693974005961 motif II; other site 693974005962 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 693974005963 putative active site pocket [active] 693974005964 4-fold oligomerization interface [polypeptide binding]; other site 693974005965 metal binding residues [ion binding]; metal-binding site 693974005966 3-fold/trimer interface [polypeptide binding]; other site 693974005967 histidinol-phosphate aminotransferase; Provisional; Region: PRK04635 693974005968 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693974005969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974005970 homodimer interface [polypeptide binding]; other site 693974005971 catalytic residue [active] 693974005972 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 693974005973 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 693974005974 NAD binding site [chemical binding]; other site 693974005975 dimerization interface [polypeptide binding]; other site 693974005976 product binding site; other site 693974005977 substrate binding site [chemical binding]; other site 693974005978 zinc binding site [ion binding]; other site 693974005979 catalytic residues [active] 693974005980 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 693974005981 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 693974005982 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 693974005983 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 693974005984 DEAD/DEAH box helicase; Region: DEAD; pfam00270 693974005985 DEAD_2; Region: DEAD_2; pfam06733 693974005986 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 693974005987 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 693974005988 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974005989 N-terminal plug; other site 693974005990 ligand-binding site [chemical binding]; other site 693974005991 Protein of unknown function (DUF938); Region: DUF938; pfam06080 693974005992 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693974005993 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693974005994 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974005995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974005996 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 693974005997 putative effector binding pocket; other site 693974005998 putative dimerization interface [polypeptide binding]; other site 693974005999 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 693974006000 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 693974006001 substrate binding site [chemical binding]; other site 693974006002 catalytic Zn binding site [ion binding]; other site 693974006003 NAD binding site [chemical binding]; other site 693974006004 structural Zn binding site [ion binding]; other site 693974006005 dimer interface [polypeptide binding]; other site 693974006006 S-formylglutathione hydrolase; Region: PLN02442 693974006007 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 693974006008 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 693974006009 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 693974006010 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 693974006011 beta-hexosaminidase; Provisional; Region: PRK05337 693974006012 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 693974006013 hypothetical protein; Provisional; Region: PRK04940 693974006014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693974006015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693974006016 acylphosphatase; Provisional; Region: PRK14429 693974006017 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 693974006018 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 693974006019 transcription-repair coupling factor; Provisional; Region: PRK10689 693974006020 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 693974006021 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693974006022 ATP binding site [chemical binding]; other site 693974006023 putative Mg++ binding site [ion binding]; other site 693974006024 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974006025 nucleotide binding region [chemical binding]; other site 693974006026 ATP-binding site [chemical binding]; other site 693974006027 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 693974006028 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 693974006029 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693974006030 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 693974006031 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693974006032 Walker A/P-loop; other site 693974006033 ATP binding site [chemical binding]; other site 693974006034 Q-loop/lid; other site 693974006035 ABC transporter signature motif; other site 693974006036 Walker B; other site 693974006037 D-loop; other site 693974006038 H-loop/switch region; other site 693974006039 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 693974006040 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693974006041 FtsX-like permease family; Region: FtsX; pfam02687 693974006042 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693974006043 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 693974006044 active site 693974006045 dimerization interface [polypeptide binding]; other site 693974006046 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 693974006047 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693974006048 serine O-acetyltransferase; Region: cysE; TIGR01172 693974006049 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 693974006050 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 693974006051 trimer interface [polypeptide binding]; other site 693974006052 active site 693974006053 substrate binding site [chemical binding]; other site 693974006054 CoA binding site [chemical binding]; other site 693974006055 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 693974006056 Rrf2 family protein; Region: rrf2_super; TIGR00738 693974006057 cysteine desulfurase; Provisional; Region: PRK14012 693974006058 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 693974006059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693974006060 catalytic residue [active] 693974006061 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 693974006062 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 693974006063 trimerization site [polypeptide binding]; other site 693974006064 active site 693974006065 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 693974006066 co-chaperone HscB; Provisional; Region: hscB; PRK05014 693974006067 DnaJ domain; Region: DnaJ; pfam00226 693974006068 HSP70 interaction site [polypeptide binding]; other site 693974006069 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 693974006070 chaperone protein HscA; Provisional; Region: hscA; PRK05183 693974006071 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 693974006072 nucleotide binding site [chemical binding]; other site 693974006073 putative NEF/HSP70 interaction site [polypeptide binding]; other site 693974006074 SBD interface [polypeptide binding]; other site 693974006075 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 693974006076 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693974006077 catalytic loop [active] 693974006078 iron binding site [ion binding]; other site 693974006079 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 693974006080 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693974006081 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 693974006082 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 693974006083 active site 693974006084 multimer interface [polypeptide binding]; other site 693974006085 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 693974006086 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 693974006087 putative dimer interface [polypeptide binding]; other site 693974006088 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 693974006089 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 693974006090 putative valine binding site [chemical binding]; other site 693974006091 dimer interface [polypeptide binding]; other site 693974006092 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 693974006093 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08979 693974006094 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693974006095 PYR/PP interface [polypeptide binding]; other site 693974006096 dimer interface [polypeptide binding]; other site 693974006097 TPP binding site [chemical binding]; other site 693974006098 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693974006099 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 693974006100 TPP-binding site [chemical binding]; other site 693974006101 dimer interface [polypeptide binding]; other site 693974006102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974006103 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 693974006104 putative substrate translocation pore; other site 693974006105 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693974006106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693974006107 DNA-binding site [nucleotide binding]; DNA binding site 693974006108 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693974006109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974006110 homodimer interface [polypeptide binding]; other site 693974006111 catalytic residue [active] 693974006112 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693974006113 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 693974006114 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693974006115 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693974006116 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693974006117 GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060 693974006118 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693974006119 putative GSH binding site (G-site) [chemical binding]; other site 693974006120 active site cysteine [active] 693974006121 putative C-terminal domain interface [polypeptide binding]; other site 693974006122 putative dimer interface [polypeptide binding]; other site 693974006123 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 693974006124 putative N-terminal domain interface [polypeptide binding]; other site 693974006125 putative dimer interface [polypeptide binding]; other site 693974006126 putative substrate binding pocket (H-site) [chemical binding]; other site 693974006127 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 693974006128 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 693974006129 active site residue [active] 693974006130 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 693974006131 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 693974006132 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 693974006133 Ligand binding site; other site 693974006134 oligomer interface; other site 693974006135 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 693974006136 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 693974006137 active site 693974006138 NAD binding site [chemical binding]; other site 693974006139 metal binding site [ion binding]; metal-binding site 693974006140 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 693974006141 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693974006142 inhibitor-cofactor binding pocket; inhibition site 693974006143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974006144 catalytic residue [active] 693974006145 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 693974006146 active site clefts [active] 693974006147 zinc binding site [ion binding]; other site 693974006148 dimer interface [polypeptide binding]; other site 693974006149 PBP superfamily domain; Region: PBP_like_2; cl17296 693974006150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693974006151 Transposase; Region: HTH_Tnp_1; pfam01527 693974006152 putative transposase OrfB; Reviewed; Region: PHA02517 693974006153 HTH-like domain; Region: HTH_21; pfam13276 693974006154 Integrase core domain; Region: rve; pfam00665 693974006155 Integrase core domain; Region: rve_3; pfam13683 693974006156 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 693974006157 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 693974006158 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 693974006159 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 693974006160 metal binding site [ion binding]; metal-binding site 693974006161 dimer interface [polypeptide binding]; other site 693974006162 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 693974006163 ArsC family; Region: ArsC; pfam03960 693974006164 putative catalytic residues [active] 693974006165 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693974006166 trimer interface [polypeptide binding]; other site 693974006167 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693974006168 eyelet of channel; other site 693974006169 Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581 693974006170 Cache domain; Region: Cache_1; pfam02743 693974006171 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974006172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974006173 dimerization interface [polypeptide binding]; other site 693974006174 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974006175 dimer interface [polypeptide binding]; other site 693974006176 putative CheW interface [polypeptide binding]; other site 693974006177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974006178 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693974006179 putative substrate translocation pore; other site 693974006180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974006181 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 693974006182 HPr interaction site; other site 693974006183 glycerol kinase (GK) interaction site [polypeptide binding]; other site 693974006184 active site 693974006185 phosphorylation site [posttranslational modification] 693974006186 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 693974006187 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 693974006188 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693974006189 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693974006190 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693974006191 dimerization domain swap beta strand [polypeptide binding]; other site 693974006192 regulatory protein interface [polypeptide binding]; other site 693974006193 active site 693974006194 regulatory phosphorylation site [posttranslational modification]; other site 693974006195 Uncharacterized conserved protein [Function unknown]; Region: COG3603 693974006196 Family description; Region: ACT_7; pfam13840 693974006197 Cache domain; Region: Cache_2; pfam08269 693974006198 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974006199 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974006200 dimerization interface [polypeptide binding]; other site 693974006201 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974006202 dimer interface [polypeptide binding]; other site 693974006203 putative CheW interface [polypeptide binding]; other site 693974006204 Protein of unknown function (DUF3334); Region: DUF3334; pfam11813 693974006205 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693974006206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693974006207 DNA binding site [nucleotide binding] 693974006208 domain linker motif; other site 693974006209 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 693974006210 putative dimerization interface [polypeptide binding]; other site 693974006211 putative ligand binding site [chemical binding]; other site 693974006212 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 693974006213 active site 693974006214 catalytic site [active] 693974006215 substrate binding site [chemical binding]; other site 693974006216 Uncharacterized conserved protein [Function unknown]; Region: COG2850 693974006217 Cupin-like domain; Region: Cupin_8; pfam13621 693974006218 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 693974006219 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693974006220 Catalytic site [active] 693974006221 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693974006222 Citrate transporter; Region: CitMHS; pfam03600 693974006223 transmembrane helices; other site 693974006224 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693974006225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974006226 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693974006227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974006228 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 693974006229 Domain interface; other site 693974006230 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 693974006231 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 693974006232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974006233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693974006234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974006235 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 693974006236 Catalytic domain of Protein Kinases; Region: PKc; cd00180 693974006237 active site 693974006238 ATP binding site [chemical binding]; other site 693974006239 substrate binding site [chemical binding]; other site 693974006240 activation loop (A-loop); other site 693974006241 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 693974006242 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 693974006243 phosphopeptide binding site; other site 693974006244 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 693974006245 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 693974006246 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 693974006247 hypothetical protein; Provisional; Region: PRK07033 693974006248 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 693974006249 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693974006250 ligand binding site [chemical binding]; other site 693974006251 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 693974006252 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 693974006253 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 693974006254 type VI secretion-associated protein, BMA_A0400 family; Region: VI_minor_4; TIGR03373 693974006255 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 693974006256 active site 693974006257 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 693974006258 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 693974006259 Protein of unknown function (DUF770); Region: DUF770; pfam05591 693974006260 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 693974006261 Protein of unknown function (DUF877); Region: DUF877; pfam05943 693974006262 Protein of unknown function (DUF877); Region: DUF877; pfam05943 693974006263 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 693974006264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693974006265 binding surface 693974006266 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 693974006267 TPR motif; other site 693974006268 ImpE protein; Region: ImpE; pfam07024 693974006269 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 693974006270 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 693974006271 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 693974006272 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 693974006273 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 693974006274 Clp amino terminal domain; Region: Clp_N; pfam02861 693974006275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974006276 Walker A motif; other site 693974006277 ATP binding site [chemical binding]; other site 693974006278 Walker B motif; other site 693974006279 arginine finger; other site 693974006280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974006281 Walker A motif; other site 693974006282 ATP binding site [chemical binding]; other site 693974006283 Walker B motif; other site 693974006284 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693974006285 Protein of unknown function (DUF796); Region: DUF796; pfam05638 693974006286 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 693974006287 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 693974006288 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693974006289 Uncharacterized conserved protein [Function unknown]; Region: COG4104 693974006290 RHS Repeat; Region: RHS_repeat; cl11982 693974006291 RHS Repeat; Region: RHS_repeat; pfam05593 693974006292 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 693974006293 RHS Repeat; Region: RHS_repeat; cl11982 693974006294 RHS Repeat; Region: RHS_repeat; cl11982 693974006295 RHS protein; Region: RHS; pfam03527 693974006296 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 693974006297 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 693974006298 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 693974006299 RHS protein; Region: RHS; pfam03527 693974006300 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 693974006301 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 693974006302 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 693974006303 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693974006304 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693974006305 RHS protein; Region: RHS; pfam03527 693974006306 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 693974006307 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 693974006308 active site flap/lid [active] 693974006309 nucleophilic elbow; other site 693974006310 catalytic triad [active] 693974006311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 693974006312 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 693974006313 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 693974006314 putative RNA binding site [nucleotide binding]; other site 693974006315 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 693974006316 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693974006317 Helix-turn-helix domain; Region: HTH_18; pfam12833 693974006318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974006319 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 693974006320 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 693974006321 Family of unknown function (DUF633); Region: DUF633; pfam04816 693974006322 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686 693974006323 nudix motif; other site 693974006324 DTW domain; Region: DTW; cl01221 693974006325 Haemolysin-III related; Region: HlyIII; cl03831 693974006326 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 693974006327 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 693974006328 ThiC-associated domain; Region: ThiC-associated; pfam13667 693974006329 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 693974006330 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 693974006331 ATP binding site [chemical binding]; other site 693974006332 substrate binding site [chemical binding]; other site 693974006333 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 693974006334 thiamine phosphate binding site [chemical binding]; other site 693974006335 active site 693974006336 pyrophosphate binding site [ion binding]; other site 693974006337 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 693974006338 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 693974006339 ATP binding site [chemical binding]; other site 693974006340 substrate interface [chemical binding]; other site 693974006341 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 693974006342 thiS-thiF/thiG interaction site; other site 693974006343 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 693974006344 ThiS interaction site; other site 693974006345 putative active site [active] 693974006346 tetramer interface [polypeptide binding]; other site 693974006347 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 693974006348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974006349 FeS/SAM binding site; other site 693974006350 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 693974006351 SprA-related family; Region: SprA-related; pfam12118 693974006352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974006353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974006354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693974006355 dimerization interface [polypeptide binding]; other site 693974006356 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 693974006357 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 693974006358 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 693974006359 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 693974006360 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 693974006361 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693974006362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974006363 S-adenosylmethionine binding site [chemical binding]; other site 693974006364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974006365 S-adenosylmethionine binding site [chemical binding]; other site 693974006366 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974006367 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974006368 substrate binding pocket [chemical binding]; other site 693974006369 membrane-bound complex binding site; other site 693974006370 hinge residues; other site 693974006371 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974006372 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974006373 substrate binding pocket [chemical binding]; other site 693974006374 membrane-bound complex binding site; other site 693974006375 hinge residues; other site 693974006376 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974006377 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974006378 substrate binding pocket [chemical binding]; other site 693974006379 membrane-bound complex binding site; other site 693974006380 hinge residues; other site 693974006381 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974006382 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974006383 metal binding site [ion binding]; metal-binding site 693974006384 active site 693974006385 I-site; other site 693974006386 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 693974006387 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 693974006388 dimer interface [polypeptide binding]; other site 693974006389 anticodon binding site; other site 693974006390 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 693974006391 homodimer interface [polypeptide binding]; other site 693974006392 motif 1; other site 693974006393 active site 693974006394 motif 2; other site 693974006395 GAD domain; Region: GAD; pfam02938 693974006396 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693974006397 active site 693974006398 motif 3; other site 693974006399 hypothetical protein; Validated; Region: PRK00110 693974006400 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 693974006401 active site 693974006402 putative DNA-binding cleft [nucleotide binding]; other site 693974006403 dimer interface [polypeptide binding]; other site 693974006404 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 693974006405 RuvA N terminal domain; Region: RuvA_N; pfam01330 693974006406 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 693974006407 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 693974006408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974006409 Walker A motif; other site 693974006410 ATP binding site [chemical binding]; other site 693974006411 Walker B motif; other site 693974006412 arginine finger; other site 693974006413 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 693974006414 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974006415 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974006416 N-terminal plug; other site 693974006417 ligand-binding site [chemical binding]; other site 693974006418 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693974006419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974006420 active site 693974006421 phosphorylation site [posttranslational modification] 693974006422 intermolecular recognition site; other site 693974006423 dimerization interface [polypeptide binding]; other site 693974006424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974006425 DNA binding site [nucleotide binding] 693974006426 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 693974006427 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 693974006428 putative active site [active] 693974006429 Zn binding site [ion binding]; other site 693974006430 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 693974006431 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 693974006432 active site 693974006433 homodimer interface [polypeptide binding]; other site 693974006434 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 693974006435 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 693974006436 tandem repeat interface [polypeptide binding]; other site 693974006437 oligomer interface [polypeptide binding]; other site 693974006438 active site residues [active] 693974006439 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 693974006440 tandem repeat interface [polypeptide binding]; other site 693974006441 oligomer interface [polypeptide binding]; other site 693974006442 active site residues [active] 693974006443 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693974006444 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 693974006445 active site 693974006446 FMN binding site [chemical binding]; other site 693974006447 2,4-decadienoyl-CoA binding site; other site 693974006448 catalytic residue [active] 693974006449 4Fe-4S cluster binding site [ion binding]; other site 693974006450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 693974006451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693974006452 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 693974006453 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693974006454 catalytic loop [active] 693974006455 iron binding site [ion binding]; other site 693974006456 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 693974006457 dimer interface [polypeptide binding]; other site 693974006458 putative radical transfer pathway; other site 693974006459 diiron center [ion binding]; other site 693974006460 tyrosyl radical; other site 693974006461 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 693974006462 ATP cone domain; Region: ATP-cone; pfam03477 693974006463 Class I ribonucleotide reductase; Region: RNR_I; cd01679 693974006464 active site 693974006465 dimer interface [polypeptide binding]; other site 693974006466 catalytic residues [active] 693974006467 effector binding site; other site 693974006468 R2 peptide binding site; other site 693974006469 phosphoglycolate phosphatase; Provisional; Region: PRK13222 693974006470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974006471 motif II; other site 693974006472 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 693974006473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974006474 S-adenosylmethionine binding site [chemical binding]; other site 693974006475 DNA gyrase subunit A; Validated; Region: PRK05560 693974006476 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693974006477 CAP-like domain; other site 693974006478 active site 693974006479 primary dimer interface [polypeptide binding]; other site 693974006480 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693974006481 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693974006482 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693974006483 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693974006484 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693974006485 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693974006486 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 693974006487 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693974006488 catalytic residue [active] 693974006489 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974006490 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974006491 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 693974006492 substrate binding pocket [chemical binding]; other site 693974006493 dimerization interface [polypeptide binding]; other site 693974006494 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 693974006495 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 693974006496 hypothetical protein; Provisional; Region: PRK10977 693974006497 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 693974006498 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693974006499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974006500 homodimer interface [polypeptide binding]; other site 693974006501 catalytic residue [active] 693974006502 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 693974006503 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 693974006504 hinge; other site 693974006505 active site 693974006506 cytidylate kinase; Provisional; Region: cmk; PRK00023 693974006507 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 693974006508 CMP-binding site; other site 693974006509 The sites determining sugar specificity; other site 693974006510 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 693974006511 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 693974006512 RNA binding site [nucleotide binding]; other site 693974006513 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 693974006514 RNA binding site [nucleotide binding]; other site 693974006515 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 693974006516 RNA binding site [nucleotide binding]; other site 693974006517 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693974006518 RNA binding site [nucleotide binding]; other site 693974006519 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693974006520 RNA binding site [nucleotide binding]; other site 693974006521 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 693974006522 RNA binding site [nucleotide binding]; other site 693974006523 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693974006524 IHF dimer interface [polypeptide binding]; other site 693974006525 IHF - DNA interface [nucleotide binding]; other site 693974006526 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 693974006527 tetratricopeptide repeat protein; Provisional; Region: PRK11788 693974006528 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 693974006529 active site 693974006530 dimer interface [polypeptide binding]; other site 693974006531 short chain dehydrogenase; Provisional; Region: PRK07576 693974006532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974006533 NAD(P) binding site [chemical binding]; other site 693974006534 active site 693974006535 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 693974006536 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 693974006537 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 693974006538 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693974006539 active site 693974006540 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 693974006541 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 693974006542 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 693974006543 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 693974006544 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 693974006545 domain interface [polypeptide binding]; other site 693974006546 putative active site [active] 693974006547 catalytic site [active] 693974006548 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 693974006549 domain interface [polypeptide binding]; other site 693974006550 putative active site [active] 693974006551 catalytic site [active] 693974006552 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 693974006553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974006554 putative substrate translocation pore; other site 693974006555 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693974006556 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 693974006557 Uncharacterized conserved protein [Function unknown]; Region: COG3148 693974006558 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 693974006559 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693974006560 active site 693974006561 DNA binding site [nucleotide binding] 693974006562 Int/Topo IB signature motif; other site 693974006563 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693974006564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693974006565 ATP binding site [chemical binding]; other site 693974006566 putative Mg++ binding site [ion binding]; other site 693974006567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974006568 nucleotide binding region [chemical binding]; other site 693974006569 ATP-binding site [chemical binding]; other site 693974006570 ecotin; Provisional; Region: PRK03719 693974006571 secondary substrate binding site; other site 693974006572 primary substrate binding site; other site 693974006573 inhibition loop; other site 693974006574 dimerization interface [polypeptide binding]; other site 693974006575 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 693974006576 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 693974006577 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693974006578 MarR family; Region: MarR; pfam01047 693974006579 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 693974006580 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693974006581 putative metal dependent hydrolase; Provisional; Region: PRK11598 693974006582 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 693974006583 Sulfatase; Region: Sulfatase; pfam00884 693974006584 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974006585 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974006586 metal binding site [ion binding]; metal-binding site 693974006587 active site 693974006588 I-site; other site 693974006589 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 693974006590 CoA binding domain; Region: CoA_binding_2; pfam13380 693974006591 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 693974006592 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 693974006593 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974006594 dimer interface [polypeptide binding]; other site 693974006595 putative CheW interface [polypeptide binding]; other site 693974006596 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 693974006597 anti sigma factor interaction site; other site 693974006598 regulatory phosphorylation site [posttranslational modification]; other site 693974006599 Response regulator receiver domain; Region: Response_reg; pfam00072 693974006600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974006601 active site 693974006602 phosphorylation site [posttranslational modification] 693974006603 intermolecular recognition site; other site 693974006604 dimerization interface [polypeptide binding]; other site 693974006605 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 693974006606 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 693974006607 Response regulator receiver domain; Region: Response_reg; pfam00072 693974006608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974006609 active site 693974006610 phosphorylation site [posttranslational modification] 693974006611 intermolecular recognition site; other site 693974006612 dimerization interface [polypeptide binding]; other site 693974006613 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 693974006614 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693974006615 putative binding surface; other site 693974006616 active site 693974006617 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 693974006618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974006619 ATP binding site [chemical binding]; other site 693974006620 Mg2+ binding site [ion binding]; other site 693974006621 G-X-G motif; other site 693974006622 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 693974006623 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 693974006624 putative CheA interaction surface; other site 693974006625 PAS domain; Region: PAS_9; pfam13426 693974006626 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974006627 dimer interface [polypeptide binding]; other site 693974006628 putative CheW interface [polypeptide binding]; other site 693974006629 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 693974006630 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 693974006631 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 693974006632 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487 693974006633 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 693974006634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974006635 active site 693974006636 phosphorylation site [posttranslational modification] 693974006637 intermolecular recognition site; other site 693974006638 dimerization interface [polypeptide binding]; other site 693974006639 CheB methylesterase; Region: CheB_methylest; pfam01339 693974006640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974006641 active site 693974006642 phosphorylation site [posttranslational modification] 693974006643 intermolecular recognition site; other site 693974006644 dimerization interface [polypeptide binding]; other site 693974006645 Response regulator receiver domain; Region: Response_reg; pfam00072 693974006646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974006647 active site 693974006648 phosphorylation site [posttranslational modification] 693974006649 intermolecular recognition site; other site 693974006650 dimerization interface [polypeptide binding]; other site 693974006651 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974006652 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974006653 metal binding site [ion binding]; metal-binding site 693974006654 active site 693974006655 I-site; other site 693974006656 Methyltransferase domain; Region: Methyltransf_25; pfam13649 693974006657 S-adenosylmethionine binding site [chemical binding]; other site 693974006658 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 693974006659 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693974006660 active site 693974006661 Nuclease-related domain; Region: NERD; pfam08378 693974006662 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 693974006663 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974006664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974006665 ABC transporter; Region: ABC_tran_2; pfam12848 693974006666 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974006667 Uncharacterized conserved protein [Function unknown]; Region: COG4628 693974006668 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693974006669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974006670 non-specific DNA binding site [nucleotide binding]; other site 693974006671 salt bridge; other site 693974006672 sequence-specific DNA binding site [nucleotide binding]; other site 693974006673 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974006674 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974006675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693974006676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974006677 dimer interface [polypeptide binding]; other site 693974006678 phosphorylation site [posttranslational modification] 693974006679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974006680 ATP binding site [chemical binding]; other site 693974006681 Mg2+ binding site [ion binding]; other site 693974006682 G-X-G motif; other site 693974006683 Response regulator receiver domain; Region: Response_reg; pfam00072 693974006684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974006685 active site 693974006686 phosphorylation site [posttranslational modification] 693974006687 intermolecular recognition site; other site 693974006688 dimerization interface [polypeptide binding]; other site 693974006689 PAS fold; Region: PAS_7; pfam12860 693974006690 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974006691 putative active site [active] 693974006692 heme pocket [chemical binding]; other site 693974006693 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974006694 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974006695 metal binding site [ion binding]; metal-binding site 693974006696 active site 693974006697 I-site; other site 693974006698 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 693974006699 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974006700 N-terminal plug; other site 693974006701 ligand-binding site [chemical binding]; other site 693974006702 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 693974006703 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 693974006704 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 693974006705 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 693974006706 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974006707 N-terminal plug; other site 693974006708 ligand-binding site [chemical binding]; other site 693974006709 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 693974006710 Uncharacterized conserved protein [Function unknown]; Region: COG3461 693974006711 multidrug efflux protein; Reviewed; Region: PRK01766 693974006712 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 693974006713 cation binding site [ion binding]; other site 693974006714 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 693974006715 Lumazine binding domain; Region: Lum_binding; pfam00677 693974006716 Lumazine binding domain; Region: Lum_binding; pfam00677 693974006717 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 693974006718 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 693974006719 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 693974006720 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 693974006721 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 693974006722 active site 693974006723 dimer interface [polypeptide binding]; other site 693974006724 motif 1; other site 693974006725 motif 2; other site 693974006726 motif 3; other site 693974006727 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 693974006728 anticodon binding site; other site 693974006729 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 693974006730 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 693974006731 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 693974006732 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 693974006733 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 693974006734 23S rRNA binding site [nucleotide binding]; other site 693974006735 L21 binding site [polypeptide binding]; other site 693974006736 L13 binding site [polypeptide binding]; other site 693974006737 thioredoxin reductase; Provisional; Region: PRK10262 693974006738 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693974006739 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693974006740 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 693974006741 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 693974006742 hexamer interface [polypeptide binding]; other site 693974006743 ligand binding site [chemical binding]; other site 693974006744 putative active site [active] 693974006745 NAD(P) binding site [chemical binding]; other site 693974006746 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 693974006747 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693974006748 putative DNA binding site [nucleotide binding]; other site 693974006749 putative Zn2+ binding site [ion binding]; other site 693974006750 AsnC family; Region: AsnC_trans_reg; pfam01037 693974006751 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 693974006752 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 693974006753 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693974006754 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 693974006755 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 693974006756 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 693974006757 recombination factor protein RarA; Reviewed; Region: PRK13342 693974006758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974006759 Walker A motif; other site 693974006760 ATP binding site [chemical binding]; other site 693974006761 Walker B motif; other site 693974006762 arginine finger; other site 693974006763 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 693974006764 camphor resistance protein CrcB; Provisional; Region: PRK14197 693974006765 seryl-tRNA synthetase; Provisional; Region: PRK05431 693974006766 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 693974006767 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 693974006768 dimer interface [polypeptide binding]; other site 693974006769 active site 693974006770 motif 1; other site 693974006771 motif 2; other site 693974006772 motif 3; other site 693974006773 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 693974006774 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 693974006775 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 693974006776 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 693974006777 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 693974006778 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 693974006779 YccA-like proteins; Region: YccA_like; cd10433 693974006780 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 693974006781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974006782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693974006783 dimerization interface [polypeptide binding]; other site 693974006784 putative transporter; Provisional; Region: PRK11043 693974006785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974006786 putative substrate translocation pore; other site 693974006787 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693974006788 putative efflux protein, MATE family; Region: matE; TIGR00797 693974006789 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693974006790 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 693974006791 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 693974006792 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 693974006793 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 693974006794 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 693974006795 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693974006796 Helix-turn-helix domain; Region: HTH_38; pfam13936 693974006797 Integrase core domain; Region: rve; pfam00665 693974006798 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693974006799 Helix-turn-helix domain; Region: HTH_38; pfam13936 693974006800 Integrase core domain; Region: rve; pfam00665 693974006801 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 693974006802 Integrase core domain; Region: rve; pfam00665 693974006803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974006804 AAA domain; Region: AAA_22; pfam13401 693974006805 Walker A motif; other site 693974006806 ATP binding site [chemical binding]; other site 693974006807 Walker B motif; other site 693974006808 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 693974006809 Int/Topo IB signature motif; other site 693974006810 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974006811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 693974006812 active site 693974006813 phosphorylation site [posttranslational modification] 693974006814 intermolecular recognition site; other site 693974006815 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 693974006816 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693974006817 Zn2+ binding site [ion binding]; other site 693974006818 Mg2+ binding site [ion binding]; other site 693974006819 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 693974006820 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 693974006821 Low-spin heme binding site [chemical binding]; other site 693974006822 Putative water exit pathway; other site 693974006823 Binuclear center (active site) [active] 693974006824 Putative proton exit pathway; other site 693974006825 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 693974006826 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 693974006827 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 693974006828 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 693974006829 Cytochrome c; Region: Cytochrom_C; pfam00034 693974006830 Cytochrome c; Region: Cytochrom_C; pfam00034 693974006831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 693974006832 FixH; Region: FixH; pfam05751 693974006833 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 693974006834 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693974006835 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693974006836 metal-binding site [ion binding] 693974006837 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693974006838 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 693974006839 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 693974006840 Family description; Region: DsbD_2; pfam13386 693974006841 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 693974006842 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693974006843 ligand binding site [chemical binding]; other site 693974006844 flexible hinge region; other site 693974006845 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693974006846 putative switch regulator; other site 693974006847 non-specific DNA interactions [nucleotide binding]; other site 693974006848 DNA binding site [nucleotide binding] 693974006849 sequence specific DNA binding site [nucleotide binding]; other site 693974006850 putative cAMP binding site [chemical binding]; other site 693974006851 universal stress protein UspE; Provisional; Region: PRK11175 693974006852 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693974006853 Ligand Binding Site [chemical binding]; other site 693974006854 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693974006855 Ligand Binding Site [chemical binding]; other site 693974006856 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 693974006857 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 693974006858 Ligand Binding Site [chemical binding]; other site 693974006859 Protein of unknown function (DUF2987); Region: DUF2987; pfam11205 693974006860 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 693974006861 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 693974006862 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 693974006863 phosphate binding site [ion binding]; other site 693974006864 putative substrate binding pocket [chemical binding]; other site 693974006865 dimer interface [polypeptide binding]; other site 693974006866 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 693974006867 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693974006868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974006869 homodimer interface [polypeptide binding]; other site 693974006870 catalytic residue [active] 693974006871 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 693974006872 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693974006873 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693974006874 Protein of unknown function (DUF2989); Region: DUF2989; pfam11207 693974006875 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 693974006876 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693974006877 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693974006878 quinolinate synthetase; Provisional; Region: PRK09375 693974006879 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 693974006880 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693974006881 E3 interaction surface; other site 693974006882 lipoyl attachment site [posttranslational modification]; other site 693974006883 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693974006884 E3 interaction surface; other site 693974006885 lipoyl attachment site [posttranslational modification]; other site 693974006886 e3 binding domain; Region: E3_binding; pfam02817 693974006887 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693974006888 3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182 693974006889 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 693974006890 alpha subunit interface [polypeptide binding]; other site 693974006891 TPP binding site [chemical binding]; other site 693974006892 heterodimer interface [polypeptide binding]; other site 693974006893 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693974006894 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 693974006895 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 693974006896 tetramer interface [polypeptide binding]; other site 693974006897 TPP-binding site [chemical binding]; other site 693974006898 heterodimer interface [polypeptide binding]; other site 693974006899 phosphorylation loop region [posttranslational modification] 693974006900 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 693974006901 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 693974006902 putative active site [active] 693974006903 Zn binding site [ion binding]; other site 693974006904 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 693974006905 phosphoglucomutase; Validated; Region: PRK07564 693974006906 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 693974006907 active site 693974006908 substrate binding site [chemical binding]; other site 693974006909 metal binding site [ion binding]; metal-binding site 693974006910 replication initiation regulator SeqA; Provisional; Region: PRK11187 693974006911 PGAP1-like protein; Region: PGAP1; pfam07819 693974006912 acyl-CoA esterase; Provisional; Region: PRK10673 693974006913 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 693974006914 LexA regulated protein; Provisional; Region: PRK11675 693974006915 flavodoxin FldA; Validated; Region: PRK09267 693974006916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 693974006917 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 693974006918 elongation factor P; Validated; Region: PRK00529 693974006919 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 693974006920 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 693974006921 RNA binding site [nucleotide binding]; other site 693974006922 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 693974006923 RNA binding site [nucleotide binding]; other site 693974006924 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 693974006925 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693974006926 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 693974006927 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 693974006928 aminotransferase AlaT; Validated; Region: PRK09265 693974006929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693974006930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974006931 homodimer interface [polypeptide binding]; other site 693974006932 catalytic residue [active] 693974006933 5'-nucleotidase; Provisional; Region: PRK03826 693974006934 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 693974006935 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 693974006936 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 693974006937 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 693974006938 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 693974006939 active site 693974006940 intersubunit interface [polypeptide binding]; other site 693974006941 catalytic residue [active] 693974006942 phosphogluconate dehydratase; Validated; Region: PRK09054 693974006943 6-phosphogluconate dehydratase; Region: edd; TIGR01196 693974006944 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 693974006945 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 693974006946 putative active site [active] 693974006947 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 693974006948 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 693974006949 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 693974006950 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 693974006951 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693974006952 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693974006953 putative active site [active] 693974006954 pyruvate kinase; Provisional; Region: PRK05826 693974006955 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 693974006956 domain interfaces; other site 693974006957 active site 693974006958 Transposase IS200 like; Region: Y1_Tnp; pfam01797 693974006959 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 693974006960 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693974006961 active site 693974006962 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 693974006963 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693974006964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974006965 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 693974006966 active site 693974006967 Zn binding site [ion binding]; other site 693974006968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 693974006969 Smr domain; Region: Smr; pfam01713 693974006970 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 693974006971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 693974006972 SEC-C motif; Region: SEC-C; pfam02810 693974006973 SEC-C motif; Region: SEC-C; pfam02810 693974006974 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693974006975 GAF domain; Region: GAF; pfam01590 693974006976 PAS domain; Region: PAS_9; pfam13426 693974006977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974006978 putative active site [active] 693974006979 heme pocket [chemical binding]; other site 693974006980 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974006981 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974006982 metal binding site [ion binding]; metal-binding site 693974006983 active site 693974006984 I-site; other site 693974006985 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974006986 Protein of unknown function (DUF406); Region: DUF406; pfam04175 693974006987 Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993 693974006988 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 693974006989 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 693974006990 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693974006991 catalytic residue [active] 693974006992 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 693974006993 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 693974006994 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 693974006995 Ligand Binding Site [chemical binding]; other site 693974006996 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 693974006997 excinuclease ABC subunit B; Provisional; Region: PRK05298 693974006998 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693974006999 ATP binding site [chemical binding]; other site 693974007000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974007001 nucleotide binding region [chemical binding]; other site 693974007002 ATP-binding site [chemical binding]; other site 693974007003 Ultra-violet resistance protein B; Region: UvrB; pfam12344 693974007004 UvrB/uvrC motif; Region: UVR; pfam02151 693974007005 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974007006 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974007007 active site 693974007008 I-site; other site 693974007009 metal binding site [ion binding]; metal-binding site 693974007010 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974007011 electron transport complex protein RsxA; Provisional; Region: PRK05151 693974007012 ferredoxin; Provisional; Region: PRK08764 693974007013 Putative Fe-S cluster; Region: FeS; pfam04060 693974007014 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693974007015 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 693974007016 SLBB domain; Region: SLBB; pfam10531 693974007017 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693974007018 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 693974007019 electron transport complex protein RnfG; Validated; Region: PRK01908 693974007020 electron transport complex RsxE subunit; Provisional; Region: PRK12405 693974007021 endonuclease III; Provisional; Region: PRK10702 693974007022 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693974007023 minor groove reading motif; other site 693974007024 helix-hairpin-helix signature motif; other site 693974007025 substrate binding pocket [chemical binding]; other site 693974007026 active site 693974007027 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 693974007028 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693974007029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974007030 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693974007031 dimerization interface [polypeptide binding]; other site 693974007032 substrate binding pocket [chemical binding]; other site 693974007033 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 693974007034 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693974007035 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 693974007036 dimer interface [polypeptide binding]; other site 693974007037 active site 693974007038 metal binding site [ion binding]; metal-binding site 693974007039 glutathione binding site [chemical binding]; other site 693974007040 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 693974007041 TMAO/DMSO reductase; Reviewed; Region: PRK05363 693974007042 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 693974007043 Moco binding site; other site 693974007044 metal coordination site [ion binding]; other site 693974007045 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 693974007046 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 693974007047 RmuC family; Region: RmuC; pfam02646 693974007048 lytic murein transglycosylase; Provisional; Region: PRK11619 693974007049 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693974007050 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693974007051 catalytic residue [active] 693974007052 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974007053 MoxR-like ATPases [General function prediction only]; Region: COG0714 693974007054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974007055 Walker A motif; other site 693974007056 ATP binding site [chemical binding]; other site 693974007057 Walker B motif; other site 693974007058 arginine finger; other site 693974007059 Protein of unknown function DUF58; Region: DUF58; pfam01882 693974007060 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 693974007061 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 693974007062 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 693974007063 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 693974007064 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 693974007065 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 693974007066 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 693974007067 Part of AAA domain; Region: AAA_19; pfam13245 693974007068 Family description; Region: UvrD_C_2; pfam13538 693974007069 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 693974007070 AAA domain; Region: AAA_30; pfam13604 693974007071 Family description; Region: UvrD_C_2; pfam13538 693974007072 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693974007073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974007074 Coenzyme A binding pocket [chemical binding]; other site 693974007075 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974007076 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974007077 metal binding site [ion binding]; metal-binding site 693974007078 active site 693974007079 I-site; other site 693974007080 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 693974007081 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693974007082 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693974007083 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693974007084 GAF domain; Region: GAF; pfam01590 693974007085 PAS domain; Region: PAS_9; pfam13426 693974007086 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974007087 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974007088 metal binding site [ion binding]; metal-binding site 693974007089 active site 693974007090 I-site; other site 693974007091 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974007092 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 693974007093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974007094 S-adenosylmethionine binding site [chemical binding]; other site 693974007095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974007096 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693974007097 putative substrate translocation pore; other site 693974007098 glucose/galactose transporter; Region: gluP; TIGR01272 693974007099 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 693974007100 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 693974007101 active site 693974007102 catalytic site [active] 693974007103 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 693974007104 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974007105 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974007106 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 693974007107 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 693974007108 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 693974007109 Ca binding site [ion binding]; other site 693974007110 active site 693974007111 homodimer interface [polypeptide binding]; other site 693974007112 catalytic site [active] 693974007113 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 693974007114 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 693974007115 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 693974007116 active site 693974007117 catalytic site [active] 693974007118 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 693974007119 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693974007120 putative metal binding site [ion binding]; other site 693974007121 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 693974007122 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 693974007123 active site 693974007124 FMN binding site [chemical binding]; other site 693974007125 substrate binding site [chemical binding]; other site 693974007126 3Fe-4S cluster binding site [ion binding]; other site 693974007127 pyruvate dehydrogenase; Provisional; Region: PRK06546 693974007128 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 693974007129 PYR/PP interface [polypeptide binding]; other site 693974007130 dimer interface [polypeptide binding]; other site 693974007131 tetramer interface [polypeptide binding]; other site 693974007132 TPP binding site [chemical binding]; other site 693974007133 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693974007134 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 693974007135 TPP-binding site [chemical binding]; other site 693974007136 Uncharacterized conserved protein [Function unknown]; Region: COG3349 693974007137 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693974007138 PRC-barrel domain; Region: PRC; pfam05239 693974007139 PRC-barrel domain; Region: PRC; pfam05239 693974007140 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 693974007141 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 693974007142 Walker A/P-loop; other site 693974007143 ATP binding site [chemical binding]; other site 693974007144 Q-loop/lid; other site 693974007145 ABC transporter signature motif; other site 693974007146 Walker B; other site 693974007147 D-loop; other site 693974007148 H-loop/switch region; other site 693974007149 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 693974007150 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 693974007151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974007152 dimer interface [polypeptide binding]; other site 693974007153 conserved gate region; other site 693974007154 ABC-ATPase subunit interface; other site 693974007155 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693974007156 rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179 693974007157 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693974007158 active site 693974007159 catalytic residues [active] 693974007160 metal binding site [ion binding]; metal-binding site 693974007161 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693974007162 active site 693974007163 DNA binding site [nucleotide binding] 693974007164 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 693974007165 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 693974007166 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 693974007167 putative active site [active] 693974007168 putative dimer interface [polypeptide binding]; other site 693974007169 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 693974007170 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 693974007171 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 693974007172 active site 693974007173 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 693974007174 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 693974007175 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 693974007176 TrkA-N domain; Region: TrkA_N; pfam02254 693974007177 TIGR03503 family protein; Region: TIGR03503 693974007178 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 693974007179 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 693974007180 active site 693974007181 catalytic site [active] 693974007182 substrate binding site [chemical binding]; other site 693974007183 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 693974007184 RNA/DNA hybrid binding site [nucleotide binding]; other site 693974007185 active site 693974007186 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 693974007187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974007188 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 693974007189 putative dimerization interface [polypeptide binding]; other site 693974007190 Methyltransferase domain; Region: Methyltransf_11; pfam08241 693974007191 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 693974007192 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 693974007193 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693974007194 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693974007195 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693974007196 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693974007197 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 693974007198 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693974007199 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 693974007200 AsmA family; Region: AsmA; pfam05170 693974007201 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 693974007202 ribonuclease activity regulator protein RraA; Reviewed; Region: PRK12487 693974007203 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 693974007204 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 693974007205 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693974007206 ATP binding site [chemical binding]; other site 693974007207 Mg++ binding site [ion binding]; other site 693974007208 motif III; other site 693974007209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974007210 nucleotide binding region [chemical binding]; other site 693974007211 ATP-binding site [chemical binding]; other site 693974007212 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 693974007213 substrate binding site [chemical binding]; other site 693974007214 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 693974007215 proposed catalytic triad [active] 693974007216 active site nucleophile [active] 693974007217 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974007218 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 693974007219 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974007220 ligand-binding site [chemical binding]; other site 693974007221 hypothetical protein; Provisional; Region: PRK11588 693974007222 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 693974007223 isoaspartyl dipeptidase; Provisional; Region: PRK10657 693974007224 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693974007225 active site 693974007226 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693974007227 EamA-like transporter family; Region: EamA; pfam00892 693974007228 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 693974007229 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693974007230 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 693974007231 classical (c) SDRs; Region: SDR_c; cd05233 693974007232 NAD(P) binding site [chemical binding]; other site 693974007233 active site 693974007234 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 693974007235 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 693974007236 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 693974007237 DNA binding residues [nucleotide binding] 693974007238 putative dimer interface [polypeptide binding]; other site 693974007239 putative metal binding residues [ion binding]; other site 693974007240 Cupin domain; Region: Cupin_2; cl17218 693974007241 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 693974007242 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 693974007243 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 693974007244 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 693974007245 type III secretion system protein YscR; Provisional; Region: PRK12797 693974007246 type III secretion system protein SsaQ; Validated; Region: PRK08035 693974007247 type III secretion system ATPase; Validated; Region: PRK06820 693974007248 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 693974007249 Walker A motif/ATP binding site; other site 693974007250 Walker B motif; other site 693974007251 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 693974007252 FHIPEP family; Region: FHIPEP; pfam00771 693974007253 type III secretion system protein SsaM; Provisional; Region: PRK15353 693974007254 SicP binding; Region: SicP-binding; pfam09119 693974007255 chaperone protein SicP; Provisional; Region: PRK15329 693974007256 HrpJ-like domain; Region: HrpJ; cl15454 693974007257 TyeA; Region: TyeA; cl07611 693974007258 type III secretion system protein SsaK; Provisional; Region: PRK15354 693974007259 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 693974007260 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 693974007261 Type III secretion needle MxiH like; Region: MxiH; cl09641 693974007262 Protein of unknown function (DUF1039); Region: DUF1039; pfam06287 693974007263 Type III secretion needle MxiH like; Region: MxiH; cl09641 693974007264 Helix-turn-helix domain; Region: HTH_18; pfam12833 693974007265 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 693974007266 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 693974007267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974007268 binding surface 693974007269 TPR motif; other site 693974007270 Salmonella outer protein D; Region: SopD; cl14701 693974007271 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 693974007272 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 693974007273 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 693974007274 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 693974007275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974007276 binding surface 693974007277 TPR motif; other site 693974007278 EspA-like secreted protein; Region: EspA; cl04069 693974007279 EspA-like secreted protein; Region: EspA; pfam03433 693974007280 type III secretion system protein SsaD; Provisional; Region: PRK15367 693974007281 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 693974007282 outer membrane secretin SsaC; Provisional; Region: PRK15346 693974007283 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693974007284 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693974007285 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 693974007286 two component system sensor kinase SsrA; Provisional; Region: PRK15347 693974007287 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974007288 dimerization interface [polypeptide binding]; other site 693974007289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974007290 dimer interface [polypeptide binding]; other site 693974007291 phosphorylation site [posttranslational modification] 693974007292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974007293 ATP binding site [chemical binding]; other site 693974007294 Mg2+ binding site [ion binding]; other site 693974007295 G-X-G motif; other site 693974007296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974007297 active site 693974007298 phosphorylation site [posttranslational modification] 693974007299 intermolecular recognition site; other site 693974007300 dimerization interface [polypeptide binding]; other site 693974007301 two component system sensor kinase SsrB; Provisional; Region: PRK15369 693974007302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974007303 active site 693974007304 phosphorylation site [posttranslational modification] 693974007305 intermolecular recognition site; other site 693974007306 dimerization interface [polypeptide binding]; other site 693974007307 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693974007308 DNA binding residues [nucleotide binding] 693974007309 dimerization interface [polypeptide binding]; other site 693974007310 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 693974007311 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 693974007312 DNA binding residues [nucleotide binding] 693974007313 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 693974007314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974007315 NAD(P) binding site [chemical binding]; other site 693974007316 active site 693974007317 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693974007318 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 693974007319 DNA binding residues [nucleotide binding] 693974007320 putative dimer interface [polypeptide binding]; other site 693974007321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693974007322 Transposase; Region: HTH_Tnp_1; pfam01527 693974007323 putative transposase OrfB; Reviewed; Region: PHA02517 693974007324 HTH-like domain; Region: HTH_21; pfam13276 693974007325 Integrase core domain; Region: rve; pfam00665 693974007326 Integrase core domain; Region: rve_3; pfam13683 693974007327 integrase; Provisional; Region: PRK09692 693974007328 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 693974007329 active site 693974007330 Int/Topo IB signature motif; other site 693974007331 Nitrate and nitrite sensing; Region: NIT; pfam08376 693974007332 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974007333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693974007334 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974007335 dimer interface [polypeptide binding]; other site 693974007336 putative CheW interface [polypeptide binding]; other site 693974007337 hypothetical protein; Provisional; Region: PRK11111 693974007338 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 693974007339 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 693974007340 putative catalytic cysteine [active] 693974007341 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 693974007342 putative active site [active] 693974007343 metal binding site [ion binding]; metal-binding site 693974007344 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 693974007345 active site 693974007346 Zn binding site [ion binding]; other site 693974007347 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693974007348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974007349 Coenzyme A binding pocket [chemical binding]; other site 693974007350 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693974007351 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693974007352 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 693974007353 Fumarase C-terminus; Region: Fumerase_C; pfam05683 693974007354 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 693974007355 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 693974007356 chorismate binding enzyme; Region: Chorismate_bind; cl10555 693974007357 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 693974007358 putative active site [active] 693974007359 putative CoA binding site [chemical binding]; other site 693974007360 nudix motif; other site 693974007361 metal binding site [ion binding]; metal-binding site 693974007362 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 693974007363 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 693974007364 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 693974007365 putative dimer interface [polypeptide binding]; other site 693974007366 putative anticodon binding site; other site 693974007367 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 693974007368 homodimer interface [polypeptide binding]; other site 693974007369 motif 1; other site 693974007370 motif 2; other site 693974007371 active site 693974007372 motif 3; other site 693974007373 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 693974007374 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 693974007375 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 693974007376 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 693974007377 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 693974007378 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 693974007379 [4Fe-4S] binding site [ion binding]; other site 693974007380 molybdopterin cofactor binding site; other site 693974007381 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 693974007382 molybdopterin cofactor binding site; other site 693974007383 NapD protein; Region: NapD; pfam03927 693974007384 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 693974007385 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 693974007386 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693974007387 ATP binding site [chemical binding]; other site 693974007388 putative Mg++ binding site [ion binding]; other site 693974007389 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974007390 nucleotide binding region [chemical binding]; other site 693974007391 ATP-binding site [chemical binding]; other site 693974007392 Helicase associated domain (HA2); Region: HA2; pfam04408 693974007393 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 693974007394 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 693974007395 FOG: CBS domain [General function prediction only]; Region: COG0517 693974007396 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 693974007397 Predicted membrane protein [Function unknown]; Region: COG4325 693974007398 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 693974007399 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 693974007400 catalytic nucleophile [active] 693974007401 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 693974007402 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693974007403 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693974007404 Surface antigen; Region: Bac_surface_Ag; pfam01103 693974007405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 693974007406 Family of unknown function (DUF490); Region: DUF490; pfam04357 693974007407 Family of unknown function (DUF490); Region: DUF490; pfam04357 693974007408 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 693974007409 5S rRNA interface [nucleotide binding]; other site 693974007410 CTC domain interface [polypeptide binding]; other site 693974007411 L16 interface [polypeptide binding]; other site 693974007412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 693974007413 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 693974007414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 693974007415 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693974007416 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 693974007417 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 693974007418 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 693974007419 Ligand binding site; other site 693974007420 DXD motif; other site 693974007421 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 693974007422 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 693974007423 sensor protein QseC; Provisional; Region: PRK10337 693974007424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974007425 dimer interface [polypeptide binding]; other site 693974007426 phosphorylation site [posttranslational modification] 693974007427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974007428 ATP binding site [chemical binding]; other site 693974007429 Mg2+ binding site [ion binding]; other site 693974007430 G-X-G motif; other site 693974007431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693974007432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974007433 active site 693974007434 phosphorylation site [posttranslational modification] 693974007435 intermolecular recognition site; other site 693974007436 dimerization interface [polypeptide binding]; other site 693974007437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974007438 DNA binding site [nucleotide binding] 693974007439 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 693974007440 ApbE family; Region: ApbE; pfam02424 693974007441 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 693974007442 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 693974007443 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693974007444 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693974007445 catalytic residues [active] 693974007446 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 693974007447 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 693974007448 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 693974007449 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 693974007450 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 693974007451 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 693974007452 putative substrate-binding site; other site 693974007453 nickel binding site [ion binding]; other site 693974007454 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 693974007455 Acylphosphatase; Region: Acylphosphatase; pfam00708 693974007456 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 693974007457 HypF finger; Region: zf-HYPF; pfam07503 693974007458 HypF finger; Region: zf-HYPF; pfam07503 693974007459 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 693974007460 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693974007461 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 693974007462 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 693974007463 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 693974007464 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 693974007465 dimerization interface [polypeptide binding]; other site 693974007466 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 693974007467 ATP binding site [chemical binding]; other site 693974007468 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 693974007469 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693974007470 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 693974007471 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 693974007472 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693974007473 putative acyl-acceptor binding pocket; other site 693974007474 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693974007475 IHF dimer interface [polypeptide binding]; other site 693974007476 IHF - DNA interface [nucleotide binding]; other site 693974007477 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 693974007478 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 693974007479 putative tRNA-binding site [nucleotide binding]; other site 693974007480 B3/4 domain; Region: B3_4; pfam03483 693974007481 tRNA synthetase B5 domain; Region: B5; smart00874 693974007482 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 693974007483 dimer interface [polypeptide binding]; other site 693974007484 motif 1; other site 693974007485 motif 3; other site 693974007486 motif 2; other site 693974007487 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 693974007488 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 693974007489 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 693974007490 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 693974007491 dimer interface [polypeptide binding]; other site 693974007492 motif 1; other site 693974007493 active site 693974007494 motif 2; other site 693974007495 motif 3; other site 693974007496 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974007497 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974007498 dimer interface [polypeptide binding]; other site 693974007499 putative CheW interface [polypeptide binding]; other site 693974007500 hypothetical protein; Provisional; Region: PRK05170 693974007501 Transglycosylase SLT domain; Region: SLT_2; pfam13406 693974007502 murein hydrolase B; Provisional; Region: PRK10760; cl17906 693974007503 YcgL domain; Region: YcgL; pfam05166 693974007504 septum formation inhibitor; Reviewed; Region: minC; PRK04804 693974007505 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 693974007506 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 693974007507 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 693974007508 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 693974007509 Switch I; other site 693974007510 Switch II; other site 693974007511 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 693974007512 ribonuclease D; Region: rnd; TIGR01388 693974007513 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 693974007514 catalytic site [active] 693974007515 putative active site [active] 693974007516 putative substrate binding site [chemical binding]; other site 693974007517 HRDC domain; Region: HRDC; pfam00570 693974007518 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 693974007519 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 693974007520 acyl-activating enzyme (AAE) consensus motif; other site 693974007521 putative AMP binding site [chemical binding]; other site 693974007522 putative active site [active] 693974007523 putative CoA binding site [chemical binding]; other site 693974007524 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693974007525 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693974007526 Predicted methyltransferase [General function prediction only]; Region: COG4798 693974007527 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693974007528 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 693974007529 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 693974007530 Glycoprotease family; Region: Peptidase_M22; pfam00814 693974007531 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 693974007532 dimer interface [polypeptide binding]; other site 693974007533 active site 693974007534 Schiff base residues; other site 693974007535 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 693974007536 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 693974007537 methionine sulfoxide reductase A; Provisional; Region: PRK14054 693974007538 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 693974007539 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 693974007540 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 693974007541 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 693974007542 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 693974007543 GTP/Mg2+ binding site [chemical binding]; other site 693974007544 G4 box; other site 693974007545 G5 box; other site 693974007546 G1 box; other site 693974007547 Switch I region; other site 693974007548 G2 box; other site 693974007549 G3 box; other site 693974007550 Switch II region; other site 693974007551 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 693974007552 Low molecular weight phosphatase family; Region: LMWPc; cd00115 693974007553 active site 693974007554 DNA ligase; Provisional; Region: PRK09125 693974007555 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 693974007556 DNA binding site [nucleotide binding] 693974007557 active site 693974007558 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 693974007559 DNA binding site [nucleotide binding] 693974007560 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 693974007561 transcriptional regulator HdfR; Provisional; Region: PRK03601 693974007562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974007563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693974007564 dimerization interface [polypeptide binding]; other site 693974007565 hypothetical protein; Provisional; Region: PRK11027 693974007566 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 693974007567 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693974007568 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693974007569 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 693974007570 PA/protease or protease-like domain interface [polypeptide binding]; other site 693974007571 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693974007572 Peptidase family M28; Region: Peptidase_M28; pfam04389 693974007573 metal binding site [ion binding]; metal-binding site 693974007574 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974007575 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974007576 metal binding site [ion binding]; metal-binding site 693974007577 active site 693974007578 I-site; other site 693974007579 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 693974007580 active site 693974007581 catalytic site [active] 693974007582 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 693974007583 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 693974007584 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 693974007585 metal ion-dependent adhesion site (MIDAS); other site 693974007586 proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789 693974007587 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693974007588 ligand binding site [chemical binding]; other site 693974007589 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 693974007590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974007591 active site 693974007592 phosphorylation site [posttranslational modification] 693974007593 intermolecular recognition site; other site 693974007594 dimerization interface [polypeptide binding]; other site 693974007595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974007596 DNA binding site [nucleotide binding] 693974007597 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 693974007598 DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622 693974007599 putative ligand binding site [chemical binding]; other site 693974007600 HAMP domain; Region: HAMP; pfam00672 693974007601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974007602 dimer interface [polypeptide binding]; other site 693974007603 phosphorylation site [posttranslational modification] 693974007604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974007605 ATP binding site [chemical binding]; other site 693974007606 Mg2+ binding site [ion binding]; other site 693974007607 G-X-G motif; other site 693974007608 cystathionine beta-lyase; Provisional; Region: PRK09028 693974007609 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693974007610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693974007611 catalytic residue [active] 693974007612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 693974007613 CreA protein; Region: CreA; pfam05981 693974007614 putative chaperone; Provisional; Region: PRK11678 693974007615 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 693974007616 nucleotide binding site [chemical binding]; other site 693974007617 putative NEF/HSP70 interaction site [polypeptide binding]; other site 693974007618 SBD interface [polypeptide binding]; other site 693974007619 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 693974007620 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 693974007621 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 693974007622 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 693974007623 domain interface [polypeptide binding]; other site 693974007624 active site 693974007625 catalytic site [active] 693974007626 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 693974007627 domain interface [polypeptide binding]; other site 693974007628 active site 693974007629 catalytic site [active] 693974007630 exopolyphosphatase; Region: exo_poly_only; TIGR03706 693974007631 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 693974007632 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693974007633 HSP70 interaction site [polypeptide binding]; other site 693974007634 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693974007635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974007636 Coenzyme A binding pocket [chemical binding]; other site 693974007637 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 693974007638 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 693974007639 generic binding surface II; other site 693974007640 generic binding surface I; other site 693974007641 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693974007642 putative catalytic site [active] 693974007643 putative metal binding site [ion binding]; other site 693974007644 putative phosphate binding site [ion binding]; other site 693974007645 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 693974007646 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 693974007647 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 693974007648 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 693974007649 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974007650 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974007651 substrate binding pocket [chemical binding]; other site 693974007652 membrane-bound complex binding site; other site 693974007653 hinge residues; other site 693974007654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693974007655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974007656 Coenzyme A binding pocket [chemical binding]; other site 693974007657 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693974007658 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693974007659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693974007660 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 693974007661 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 693974007662 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693974007663 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693974007664 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 693974007665 putative FMN binding site [chemical binding]; other site 693974007666 DoxX; Region: DoxX; pfam07681 693974007667 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 693974007668 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 693974007669 Phosphotransferase enzyme family; Region: APH; pfam01636 693974007670 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 693974007671 substrate binding site [chemical binding]; other site 693974007672 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 693974007673 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693974007674 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974007675 N-terminal plug; other site 693974007676 ligand-binding site [chemical binding]; other site 693974007677 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 693974007678 putative dimer interface [polypeptide binding]; other site 693974007679 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693974007680 CoenzymeA binding site [chemical binding]; other site 693974007681 subunit interaction site [polypeptide binding]; other site 693974007682 PHB binding site; other site 693974007683 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693974007684 CoenzymeA binding site [chemical binding]; other site 693974007685 subunit interaction site [polypeptide binding]; other site 693974007686 PHB binding site; other site 693974007687 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 693974007688 nucleotide binding site/active site [active] 693974007689 HIT family signature motif; other site 693974007690 catalytic residue [active] 693974007691 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 693974007692 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 693974007693 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 693974007694 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 693974007695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693974007696 DNA binding residues [nucleotide binding] 693974007697 dimerization interface [polypeptide binding]; other site 693974007698 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 693974007699 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693974007700 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693974007701 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 693974007702 CPxP motif; other site 693974007703 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 693974007704 Peptidase family M48; Region: Peptidase_M48; cl12018 693974007705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974007706 TPR motif; other site 693974007707 binding surface 693974007708 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 693974007709 ArsC family; Region: ArsC; pfam03960 693974007710 catalytic residues [active] 693974007711 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 693974007712 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 693974007713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974007714 Walker A motif; other site 693974007715 ATP binding site [chemical binding]; other site 693974007716 Walker B motif; other site 693974007717 arginine finger; other site 693974007718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249 693974007719 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 693974007720 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 693974007721 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 693974007722 putative GSH binding site [chemical binding]; other site 693974007723 catalytic residues [active] 693974007724 superoxide dismutase; Provisional; Region: PRK10543 693974007725 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 693974007726 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 693974007727 PrkA family serine protein kinase; Provisional; Region: PRK15455 693974007728 AAA ATPase domain; Region: AAA_16; pfam13191 693974007729 Walker A motif; other site 693974007730 ATP binding site [chemical binding]; other site 693974007731 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 693974007732 hypothetical protein; Provisional; Region: PRK05325 693974007733 SpoVR family protein; Provisional; Region: PRK11767 693974007734 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 693974007735 fatty acid metabolism regulator; Provisional; Region: PRK04984 693974007736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693974007737 DNA-binding site [nucleotide binding]; DNA binding site 693974007738 FadR C-terminal domain; Region: FadR_C; pfam07840 693974007739 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 693974007740 disulfide bond formation protein B; Provisional; Region: PRK01749 693974007741 Cache domain; Region: Cache_1; pfam02743 693974007742 PAS fold; Region: PAS_4; pfam08448 693974007743 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693974007744 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 693974007745 Mg2+ binding site [ion binding]; other site 693974007746 G-X-G motif; other site 693974007747 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 693974007748 Protein of unknown function (DUF3802); Region: DUF3802; pfam12290 693974007749 YceI-like domain; Region: YceI; pfam04264 693974007750 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 693974007751 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 693974007752 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693974007753 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 693974007754 Adenosylmethionine decarboxylase; Region: SAM_decarbox; cl03253 693974007755 arginine decarboxylase; Provisional; Region: PRK05354 693974007756 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 693974007757 dimer interface [polypeptide binding]; other site 693974007758 active site 693974007759 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693974007760 catalytic residues [active] 693974007761 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 693974007762 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 693974007763 S1 domain; Region: S1_2; pfam13509 693974007764 hypothetical protein; Provisional; Region: PRK11239 693974007765 Protein of unknown function, DUF480; Region: DUF480; pfam04337 693974007766 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693974007767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974007768 Walker A/P-loop; other site 693974007769 ATP binding site [chemical binding]; other site 693974007770 Q-loop/lid; other site 693974007771 ABC transporter signature motif; other site 693974007772 Walker B; other site 693974007773 D-loop; other site 693974007774 H-loop/switch region; other site 693974007775 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693974007776 IHF - DNA interface [nucleotide binding]; other site 693974007777 IHF dimer interface [polypeptide binding]; other site 693974007778 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 693974007779 AAA domain; Region: AAA_26; pfam13500 693974007780 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 693974007781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974007782 S-adenosylmethionine binding site [chemical binding]; other site 693974007783 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 693974007784 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 693974007785 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693974007786 catalytic residue [active] 693974007787 biotin synthase; Provisional; Region: PRK15108 693974007788 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974007789 FeS/SAM binding site; other site 693974007790 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 693974007791 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693974007792 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 693974007793 inhibitor-cofactor binding pocket; inhibition site 693974007794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974007795 catalytic residue [active] 693974007796 Cache domain; Region: Cache_2; pfam08269 693974007797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974007798 dimerization interface [polypeptide binding]; other site 693974007799 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974007800 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974007801 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974007802 dimer interface [polypeptide binding]; other site 693974007803 putative CheW interface [polypeptide binding]; other site 693974007804 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 693974007805 Na binding site [ion binding]; other site 693974007806 PAS domain; Region: PAS; smart00091 693974007807 PAS fold; Region: PAS_7; pfam12860 693974007808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693974007809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974007810 dimer interface [polypeptide binding]; other site 693974007811 phosphorylation site [posttranslational modification] 693974007812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974007813 ATP binding site [chemical binding]; other site 693974007814 Mg2+ binding site [ion binding]; other site 693974007815 G-X-G motif; other site 693974007816 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974007817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974007818 active site 693974007819 phosphorylation site [posttranslational modification] 693974007820 intermolecular recognition site; other site 693974007821 dimerization interface [polypeptide binding]; other site 693974007822 acetyl-CoA synthetase; Provisional; Region: PRK00174 693974007823 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 693974007824 active site 693974007825 CoA binding site [chemical binding]; other site 693974007826 acyl-activating enzyme (AAE) consensus motif; other site 693974007827 AMP binding site [chemical binding]; other site 693974007828 acetate binding site [chemical binding]; other site 693974007829 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 693974007830 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693974007831 ATP binding site [chemical binding]; other site 693974007832 putative Mg++ binding site [ion binding]; other site 693974007833 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974007834 nucleotide binding region [chemical binding]; other site 693974007835 ATP-binding site [chemical binding]; other site 693974007836 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 693974007837 GSH binding site [chemical binding]; other site 693974007838 catalytic residues [active] 693974007839 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 693974007840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974007841 binding surface 693974007842 TPR motif; other site 693974007843 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 693974007844 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693974007845 ligand binding site [chemical binding]; other site 693974007846 translocation protein TolB; Provisional; Region: tolB; PRK04792 693974007847 TolB amino-terminal domain; Region: TolB_N; pfam04052 693974007848 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693974007849 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693974007850 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693974007851 TolA protein; Region: tolA_full; TIGR02794 693974007852 TolA C-terminal; Region: TolA; pfam06519 693974007853 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 693974007854 TolR protein; Region: tolR; TIGR02801 693974007855 TolQ protein; Region: tolQ; TIGR02796 693974007856 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693974007857 active site 693974007858 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 693974007859 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693974007860 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693974007861 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693974007862 ligand binding site [chemical binding]; other site 693974007863 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 693974007864 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 693974007865 dimer interface [polypeptide binding]; other site 693974007866 catalytic site [active] 693974007867 putative active site [active] 693974007868 putative substrate binding site [chemical binding]; other site 693974007869 peroxidase; Provisional; Region: PRK15000 693974007870 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 693974007871 dimer interface [polypeptide binding]; other site 693974007872 decamer (pentamer of dimers) interface [polypeptide binding]; other site 693974007873 catalytic triad [active] 693974007874 peroxidatic and resolving cysteines [active] 693974007875 Predicted permease [General function prediction only]; Region: COG2056 693974007876 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 693974007877 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693974007878 active site 693974007879 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 693974007880 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 693974007881 dimerization interface [polypeptide binding]; other site 693974007882 putative ATP binding site [chemical binding]; other site 693974007883 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 693974007884 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 693974007885 active site 693974007886 substrate binding site [chemical binding]; other site 693974007887 cosubstrate binding site; other site 693974007888 catalytic site [active] 693974007889 UMP phosphatase; Provisional; Region: PRK10444 693974007890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974007891 active site 693974007892 motif I; other site 693974007893 motif II; other site 693974007894 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974007895 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693974007896 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 693974007897 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 693974007898 PA/protease or protease-like domain interface [polypeptide binding]; other site 693974007899 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 693974007900 metal binding site [ion binding]; metal-binding site 693974007901 asparagine synthetase B; Provisional; Region: asnB; PRK09431 693974007902 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 693974007903 active site 693974007904 dimer interface [polypeptide binding]; other site 693974007905 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 693974007906 Ligand Binding Site [chemical binding]; other site 693974007907 Molecular Tunnel; other site 693974007908 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 693974007909 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 693974007910 active site 693974007911 nucleophile elbow; other site 693974007912 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693974007913 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974007914 N-terminal plug; other site 693974007915 ligand-binding site [chemical binding]; other site 693974007916 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 693974007917 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 693974007918 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693974007919 active site 693974007920 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 693974007921 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 693974007922 active site 693974007923 phosphate binding residues; other site 693974007924 catalytic residues [active] 693974007925 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 693974007926 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693974007927 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 693974007928 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 693974007929 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693974007930 dimer interface [polypeptide binding]; other site 693974007931 active site 693974007932 acyl carrier protein; Provisional; Region: acpP; PRK00982 693974007933 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693974007934 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 693974007935 NAD(P) binding site [chemical binding]; other site 693974007936 homotetramer interface [polypeptide binding]; other site 693974007937 homodimer interface [polypeptide binding]; other site 693974007938 active site 693974007939 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 693974007940 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 693974007941 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 693974007942 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 693974007943 dimer interface [polypeptide binding]; other site 693974007944 active site 693974007945 CoA binding pocket [chemical binding]; other site 693974007946 putative phosphate acyltransferase; Provisional; Region: PRK05331 693974007947 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 693974007948 hypothetical protein; Provisional; Region: PRK11193 693974007949 Maf-like protein; Region: Maf; pfam02545 693974007950 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 693974007951 active site 693974007952 dimer interface [polypeptide binding]; other site 693974007953 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 693974007954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974007955 motif II; other site 693974007956 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 693974007957 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693974007958 RNA binding surface [nucleotide binding]; other site 693974007959 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693974007960 active site 693974007961 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 693974007962 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 693974007963 homodimer interface [polypeptide binding]; other site 693974007964 oligonucleotide binding site [chemical binding]; other site 693974007965 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 693974007966 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693974007967 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693974007968 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693974007969 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693974007970 DNA-binding site [nucleotide binding]; DNA binding site 693974007971 RNA-binding motif; other site 693974007972 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 693974007973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974007974 S-adenosylmethionine binding site [chemical binding]; other site 693974007975 DinB family; Region: DinB; cl17821 693974007976 Uncharacterized conserved protein [Function unknown]; Region: COG3791 693974007977 Omptin family; Region: Omptin; cl01886 693974007978 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 693974007979 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 693974007980 dimer interface [polypeptide binding]; other site 693974007981 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693974007982 ligand binding site [chemical binding]; other site 693974007983 exonuclease I; Provisional; Region: sbcB; PRK11779 693974007984 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 693974007985 active site 693974007986 catalytic site [active] 693974007987 substrate binding site [chemical binding]; other site 693974007988 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 693974007989 cytidine deaminase; Provisional; Region: PRK09027 693974007990 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 693974007991 active site 693974007992 catalytic motif [active] 693974007993 Zn binding site [ion binding]; other site 693974007994 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 693974007995 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 693974007996 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693974007997 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693974007998 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693974007999 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 693974008000 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 693974008001 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 693974008002 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 693974008003 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693974008004 Predicted membrane protein [Function unknown]; Region: COG3235 693974008005 Uncharacterized conserved protein [Function unknown]; Region: COG2835 693974008006 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 693974008007 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 693974008008 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 693974008009 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693974008010 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 693974008011 Walker A/P-loop; other site 693974008012 ATP binding site [chemical binding]; other site 693974008013 Q-loop/lid; other site 693974008014 ABC transporter signature motif; other site 693974008015 Walker B; other site 693974008016 D-loop; other site 693974008017 H-loop/switch region; other site 693974008018 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 693974008019 ComEC family competence protein; Provisional; Region: PRK11539 693974008020 Competence protein; Region: Competence; pfam03772 693974008021 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 693974008022 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 693974008023 NnrS protein; Region: NnrS; pfam05940 693974008024 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 693974008025 PilZ domain; Region: PilZ; pfam07238 693974008026 ParA-like protein; Provisional; Region: PHA02518 693974008027 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693974008028 P-loop; other site 693974008029 Magnesium ion binding site [ion binding]; other site 693974008030 Protein of unknown function (DUF2492); Region: DUF2492; pfam10678 693974008031 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 693974008032 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693974008033 GAF domain; Region: GAF; pfam01590 693974008034 Histidine kinase; Region: His_kinase; pfam06580 693974008035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974008036 ATP binding site [chemical binding]; other site 693974008037 Mg2+ binding site [ion binding]; other site 693974008038 G-X-G motif; other site 693974008039 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 693974008040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974008041 active site 693974008042 phosphorylation site [posttranslational modification] 693974008043 intermolecular recognition site; other site 693974008044 dimerization interface [polypeptide binding]; other site 693974008045 LytTr DNA-binding domain; Region: LytTR; pfam04397 693974008046 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 693974008047 Carbon starvation protein CstA; Region: CstA; pfam02554 693974008048 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 693974008049 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 693974008050 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 693974008051 dimerization interface [polypeptide binding]; other site 693974008052 active site 693974008053 hypothetical protein; Provisional; Region: PRK11020 693974008054 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 693974008055 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 693974008056 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 693974008057 ATP cone domain; Region: ATP-cone; pfam03477 693974008058 Class III ribonucleotide reductase; Region: RNR_III; cd01675 693974008059 effector binding site; other site 693974008060 active site 693974008061 Zn binding site [ion binding]; other site 693974008062 glycine loop; other site 693974008063 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693974008064 MarR family; Region: MarR; pfam01047 693974008065 Prostaglandin dehydrogenases; Region: PGDH; cd05288 693974008066 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 693974008067 NAD(P) binding site [chemical binding]; other site 693974008068 substrate binding site [chemical binding]; other site 693974008069 dimer interface [polypeptide binding]; other site 693974008070 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 693974008071 active site 693974008072 nucleophile elbow; other site 693974008073 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 693974008074 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693974008075 ATP binding site [chemical binding]; other site 693974008076 Mg++ binding site [ion binding]; other site 693974008077 motif III; other site 693974008078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974008079 nucleotide binding region [chemical binding]; other site 693974008080 ATP-binding site [chemical binding]; other site 693974008081 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 693974008082 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 693974008083 putative peptidase; Provisional; Region: PRK11649 693974008084 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 693974008085 Peptidase family M23; Region: Peptidase_M23; pfam01551 693974008086 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 693974008087 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 693974008088 Walker A/P-loop; other site 693974008089 ATP binding site [chemical binding]; other site 693974008090 Q-loop/lid; other site 693974008091 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 693974008092 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 693974008093 ABC transporter signature motif; other site 693974008094 Walker B; other site 693974008095 D-loop; other site 693974008096 H-loop/switch region; other site 693974008097 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 693974008098 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693974008099 active site 693974008100 metal binding site [ion binding]; metal-binding site 693974008101 DNA binding site [nucleotide binding] 693974008102 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 693974008103 hypothetical protein; Provisional; Region: PRK10621 693974008104 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693974008105 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693974008106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974008107 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 693974008108 dimerization interface [polypeptide binding]; other site 693974008109 substrate binding pocket [chemical binding]; other site 693974008110 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 693974008111 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693974008112 RNA binding surface [nucleotide binding]; other site 693974008113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693974008114 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693974008115 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 693974008116 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 693974008117 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974008118 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974008119 metal binding site [ion binding]; metal-binding site 693974008120 active site 693974008121 I-site; other site 693974008122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974008123 TPR motif; other site 693974008124 binding surface 693974008125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974008126 binding surface 693974008127 TPR motif; other site 693974008128 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 693974008129 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693974008130 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 693974008131 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 693974008132 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 693974008133 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 693974008134 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 693974008135 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 693974008136 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974008137 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974008138 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974008139 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 693974008140 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974008141 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974008142 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974008143 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693974008144 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693974008145 trimer interface [polypeptide binding]; other site 693974008146 eyelet of channel; other site 693974008147 DNA polymerase II; Reviewed; Region: PRK05762 693974008148 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 693974008149 active site 693974008150 catalytic site [active] 693974008151 substrate binding site [chemical binding]; other site 693974008152 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 693974008153 active site 693974008154 metal-binding site 693974008155 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 693974008156 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 693974008157 Protein of unknown function (DUF570); Region: DUF570; pfam04489 693974008158 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 693974008159 hypothetical protein; Provisional; Region: PRK10621 693974008160 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693974008161 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 693974008162 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 693974008163 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 693974008164 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 693974008165 putative active site [active] 693974008166 Zn binding site [ion binding]; other site 693974008167 Late competence development protein ComFB; Region: ComFB; pfam10719 693974008168 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 693974008169 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 693974008170 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 693974008171 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693974008172 homodimer interface [polypeptide binding]; other site 693974008173 substrate-cofactor binding pocket; other site 693974008174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974008175 catalytic residue [active] 693974008176 hypothetical protein; Provisional; Region: PRK05415 693974008177 Domain of unknown function (DUF697); Region: DUF697; pfam05128 693974008178 YcjX-like family, DUF463; Region: DUF463; pfam04317 693974008179 phage shock protein C; Region: phageshock_pspC; TIGR02978 693974008180 PspC domain; Region: PspC; cl00864 693974008181 phage shock protein B; Provisional; Region: pspB; PRK09458 693974008182 phage shock protein A; Region: phageshock_pspA; TIGR02977 693974008183 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 693974008184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974008185 Walker A motif; other site 693974008186 ATP binding site [chemical binding]; other site 693974008187 Walker B motif; other site 693974008188 arginine finger; other site 693974008189 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693974008190 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693974008191 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 693974008192 peptide binding site [polypeptide binding]; other site 693974008193 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693974008194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974008195 dimer interface [polypeptide binding]; other site 693974008196 conserved gate region; other site 693974008197 putative PBP binding loops; other site 693974008198 ABC-ATPase subunit interface; other site 693974008199 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 693974008200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974008201 dimer interface [polypeptide binding]; other site 693974008202 conserved gate region; other site 693974008203 putative PBP binding loops; other site 693974008204 ABC-ATPase subunit interface; other site 693974008205 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170 693974008206 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693974008207 Walker A/P-loop; other site 693974008208 ATP binding site [chemical binding]; other site 693974008209 Q-loop/lid; other site 693974008210 ABC transporter signature motif; other site 693974008211 Walker B; other site 693974008212 D-loop; other site 693974008213 H-loop/switch region; other site 693974008214 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 693974008215 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 693974008216 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693974008217 Walker A/P-loop; other site 693974008218 ATP binding site [chemical binding]; other site 693974008219 Q-loop/lid; other site 693974008220 ABC transporter signature motif; other site 693974008221 Walker B; other site 693974008222 D-loop; other site 693974008223 H-loop/switch region; other site 693974008224 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693974008225 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 693974008226 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 693974008227 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 693974008228 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 693974008229 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 693974008230 periplasmic folding chaperone; Provisional; Region: PRK10788 693974008231 SurA N-terminal domain; Region: SurA_N_3; cl07813 693974008232 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693974008233 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693974008234 IHF dimer interface [polypeptide binding]; other site 693974008235 IHF - DNA interface [nucleotide binding]; other site 693974008236 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 693974008237 Found in ATP-dependent protease La (LON); Region: LON; smart00464 693974008238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974008239 Walker A motif; other site 693974008240 ATP binding site [chemical binding]; other site 693974008241 Walker B motif; other site 693974008242 arginine finger; other site 693974008243 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693974008244 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 693974008245 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 693974008246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974008247 Walker A motif; other site 693974008248 ATP binding site [chemical binding]; other site 693974008249 Walker B motif; other site 693974008250 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693974008251 Clp protease; Region: CLP_protease; pfam00574 693974008252 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 693974008253 oligomer interface [polypeptide binding]; other site 693974008254 active site residues [active] 693974008255 trigger factor; Provisional; Region: tig; PRK01490 693974008256 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693974008257 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 693974008258 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 693974008259 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 693974008260 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 693974008261 homodimer interface [polypeptide binding]; other site 693974008262 NADP binding site [chemical binding]; other site 693974008263 substrate binding site [chemical binding]; other site 693974008264 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 693974008265 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 693974008266 active site 693974008267 HIGH motif; other site 693974008268 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 693974008269 KMSKS motif; other site 693974008270 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 693974008271 tRNA binding surface [nucleotide binding]; other site 693974008272 anticodon binding site; other site 693974008273 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 693974008274 substrate binding site [chemical binding]; other site 693974008275 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693974008276 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 693974008277 putative active site [active] 693974008278 putative metal binding site [ion binding]; other site 693974008279 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 693974008280 active site 693974008281 dinuclear metal binding site [ion binding]; other site 693974008282 dimerization interface [polypeptide binding]; other site 693974008283 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 693974008284 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 693974008285 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693974008286 active site 693974008287 HIGH motif; other site 693974008288 nucleotide binding site [chemical binding]; other site 693974008289 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 693974008290 KMSKS motif; other site 693974008291 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 693974008292 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 693974008293 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 693974008294 G1 box; other site 693974008295 GTP/Mg2+ binding site [chemical binding]; other site 693974008296 Switch I region; other site 693974008297 G2 box; other site 693974008298 G3 box; other site 693974008299 Switch II region; other site 693974008300 G4 box; other site 693974008301 G5 box; other site 693974008302 Nucleoside recognition; Region: Gate; pfam07670 693974008303 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 693974008304 Nucleoside recognition; Region: Gate; pfam07670 693974008305 FeoA domain; Region: FeoA; pfam04023 693974008306 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 693974008307 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 693974008308 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 693974008309 Protein of unknown function (DUF3374); Region: DUF3374; pfam11854 693974008310 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 693974008311 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 693974008312 heme-binding residues [chemical binding]; other site 693974008313 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 693974008314 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 693974008315 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 693974008316 heme-binding residues [chemical binding]; other site 693974008317 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 693974008318 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 693974008319 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 693974008320 Protein of unknown function (DUF3374); Region: DUF3374; pfam11854 693974008321 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 693974008322 putative uracil binding site [chemical binding]; other site 693974008323 putative active site [active] 693974008324 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 693974008325 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 693974008326 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 693974008327 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 693974008328 putative heme binding pocket [chemical binding]; other site 693974008329 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 693974008330 fructuronate transporter; Provisional; Region: PRK10034; cl15264 693974008331 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 693974008332 putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799 693974008333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693974008334 catalytic residue [active] 693974008335 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 693974008336 trimer interface [polypeptide binding]; other site 693974008337 active site 693974008338 substrate binding site [chemical binding]; other site 693974008339 CoA binding site [chemical binding]; other site 693974008340 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693974008341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974008342 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693974008343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974008344 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 693974008345 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 693974008346 Aerolysin toxin; Region: Aerolysin; cl03107 693974008347 Predicted transcriptional regulator [Transcription]; Region: COG2378 693974008348 HTH domain; Region: HTH_11; pfam08279 693974008349 WYL domain; Region: WYL; pfam13280 693974008350 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 693974008351 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693974008352 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693974008353 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 693974008354 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 693974008355 active site 693974008356 substrate binding site [chemical binding]; other site 693974008357 metal binding site [ion binding]; metal-binding site 693974008358 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 693974008359 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 693974008360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974008361 putative substrate translocation pore; other site 693974008362 POT family; Region: PTR2; cl17359 693974008363 Protein of unknown function (DUF3624); Region: DUF3624; pfam12292 693974008364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974008365 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 693974008366 NAD(P) binding site [chemical binding]; other site 693974008367 active site 693974008368 peptide synthase; Provisional; Region: PRK09274 693974008369 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693974008370 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 693974008371 acyl-activating enzyme (AAE) consensus motif; other site 693974008372 putative AMP binding site [chemical binding]; other site 693974008373 putative active site [active] 693974008374 putative CoA binding site [chemical binding]; other site 693974008375 haloalkane dehalogenase; Provisional; Region: PRK03592 693974008376 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 693974008377 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 693974008378 dimer interface [polypeptide binding]; other site 693974008379 active site 693974008380 CoA binding pocket [chemical binding]; other site 693974008381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974008382 S-adenosylmethionine binding site [chemical binding]; other site 693974008383 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 693974008384 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693974008385 active site 693974008386 BCCT family transporter; Region: BCCT; pfam02028 693974008387 Protein of unknown function (DUF502); Region: DUF502; pfam04367 693974008388 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 693974008389 dimer interface [polypeptide binding]; other site 693974008390 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693974008391 metal binding site [ion binding]; metal-binding site 693974008392 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 693974008393 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 693974008394 transcriptional regulator PhoU; Provisional; Region: PRK11115 693974008395 PhoU domain; Region: PhoU; pfam01895 693974008396 PhoU domain; Region: PhoU; pfam01895 693974008397 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 693974008398 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 693974008399 Walker A/P-loop; other site 693974008400 ATP binding site [chemical binding]; other site 693974008401 Q-loop/lid; other site 693974008402 ABC transporter signature motif; other site 693974008403 Walker B; other site 693974008404 D-loop; other site 693974008405 H-loop/switch region; other site 693974008406 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 693974008407 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 693974008408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974008409 dimer interface [polypeptide binding]; other site 693974008410 conserved gate region; other site 693974008411 putative PBP binding loops; other site 693974008412 ABC-ATPase subunit interface; other site 693974008413 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 693974008414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974008415 conserved gate region; other site 693974008416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974008417 ABC-ATPase subunit interface; other site 693974008418 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 693974008419 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 693974008420 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693974008421 EamA-like transporter family; Region: EamA; pfam00892 693974008422 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693974008423 EamA-like transporter family; Region: EamA; pfam00892 693974008424 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 693974008425 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 693974008426 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 693974008427 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693974008428 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 693974008429 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693974008430 Beta-lactamase; Region: Beta-lactamase; pfam00144 693974008431 SseB protein; Region: SseB; cl06279 693974008432 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 693974008433 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 693974008434 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 693974008435 signal peptidase I; Provisional; Region: PRK10861 693974008436 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693974008437 Catalytic site [active] 693974008438 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693974008439 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 693974008440 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 693974008441 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 693974008442 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693974008443 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693974008444 Walker A/P-loop; other site 693974008445 ATP binding site [chemical binding]; other site 693974008446 Q-loop/lid; other site 693974008447 ABC transporter signature motif; other site 693974008448 Walker B; other site 693974008449 D-loop; other site 693974008450 H-loop/switch region; other site 693974008451 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974008452 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 693974008453 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974008454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693974008455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974008456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974008457 DNA binding site [nucleotide binding] 693974008458 AAA ATPase domain; Region: AAA_16; pfam13191 693974008459 Domain of unknown function (DUF1888); Region: DUF1888; pfam08985 693974008460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 693974008461 PAS domain; Region: PAS_9; pfam13426 693974008462 putative active site [active] 693974008463 heme pocket [chemical binding]; other site 693974008464 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974008465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974008466 metal binding site [ion binding]; metal-binding site 693974008467 active site 693974008468 I-site; other site 693974008469 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 693974008470 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693974008471 FAD binding domain; Region: FAD_binding_4; pfam01565 693974008472 EamA-like transporter family; Region: EamA; pfam00892 693974008473 EamA-like transporter family; Region: EamA; pfam00892 693974008474 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 693974008475 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 693974008476 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 693974008477 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974008478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974008479 Walker A/P-loop; other site 693974008480 ATP binding site [chemical binding]; other site 693974008481 Q-loop/lid; other site 693974008482 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974008483 Walker B; other site 693974008484 ABC transporter; Region: ABC_tran_2; pfam12848 693974008485 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693974008486 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693974008487 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693974008488 metal-binding site [ion binding] 693974008489 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693974008490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974008491 motif II; other site 693974008492 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 693974008493 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 693974008494 DNA binding residues [nucleotide binding] 693974008495 dimer interface [polypeptide binding]; other site 693974008496 copper binding site [ion binding]; other site 693974008497 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693974008498 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693974008499 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 693974008500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974008501 NAD(P) binding site [chemical binding]; other site 693974008502 active site 693974008503 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693974008504 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 693974008505 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 693974008506 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693974008507 substrate binding site [chemical binding]; other site 693974008508 oxyanion hole (OAH) forming residues; other site 693974008509 trimer interface [polypeptide binding]; other site 693974008510 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 693974008511 enoyl-CoA hydratase; Provisional; Region: PRK09076 693974008512 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693974008513 substrate binding site [chemical binding]; other site 693974008514 oxyanion hole (OAH) forming residues; other site 693974008515 trimer interface [polypeptide binding]; other site 693974008516 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693974008517 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693974008518 active site 693974008519 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 693974008520 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 693974008521 tetrameric interface [polypeptide binding]; other site 693974008522 NAD binding site [chemical binding]; other site 693974008523 catalytic residues [active] 693974008524 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 693974008525 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693974008526 dimer interface [polypeptide binding]; other site 693974008527 active site 693974008528 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 693974008529 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974008530 HAMP domain; Region: HAMP; pfam00672 693974008531 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974008532 dimer interface [polypeptide binding]; other site 693974008533 putative CheW interface [polypeptide binding]; other site 693974008534 homoserine O-succinyltransferase; Provisional; Region: PRK05368 693974008535 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 693974008536 proposed active site lysine [active] 693974008537 conserved cys residue [active] 693974008538 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 693974008539 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 693974008540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974008541 NAD(P) binding site [chemical binding]; other site 693974008542 active site 693974008543 outer membrane protein W; Provisional; Region: PRK10959 693974008544 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 693974008545 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 693974008546 maleylacetoacetate isomerase; Region: maiA; TIGR01262 693974008547 C-terminal domain interface [polypeptide binding]; other site 693974008548 GSH binding site (G-site) [chemical binding]; other site 693974008549 putative dimer interface [polypeptide binding]; other site 693974008550 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 693974008551 dimer interface [polypeptide binding]; other site 693974008552 N-terminal domain interface [polypeptide binding]; other site 693974008553 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 693974008554 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693974008555 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693974008556 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 693974008557 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 693974008558 putative aromatic amino acid binding site; other site 693974008559 PAS domain; Region: PAS; smart00091 693974008560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974008561 Walker A motif; other site 693974008562 ATP binding site [chemical binding]; other site 693974008563 Walker B motif; other site 693974008564 arginine finger; other site 693974008565 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 693974008566 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 693974008567 aromatic arch; other site 693974008568 DCoH dimer interaction site [polypeptide binding]; other site 693974008569 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 693974008570 DCoH tetramer interaction site [polypeptide binding]; other site 693974008571 substrate binding site [chemical binding]; other site 693974008572 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 693974008573 cofactor binding site; other site 693974008574 metal binding site [ion binding]; metal-binding site 693974008575 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 693974008576 active site 693974008577 tetramer interface; other site 693974008578 UDP-glucose 4-epimerase; Region: PLN02240 693974008579 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 693974008580 NAD binding site [chemical binding]; other site 693974008581 homodimer interface [polypeptide binding]; other site 693974008582 active site 693974008583 substrate binding site [chemical binding]; other site 693974008584 ferredoxin-type protein; Provisional; Region: PRK10194 693974008585 4Fe-4S binding domain; Region: Fer4; cl02805 693974008586 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 693974008587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974008588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974008589 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693974008590 dimerization interface [polypeptide binding]; other site 693974008591 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 693974008592 Protein of unknown function (DUF2982); Region: DUF2982; pfam11201 693974008593 Uncharacterized conserved protein [Function unknown]; Region: COG1434 693974008594 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693974008595 putative active site [active] 693974008596 fructokinase; Reviewed; Region: PRK09557 693974008597 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693974008598 nucleotide binding site [chemical binding]; other site 693974008599 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 693974008600 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693974008601 active site 693974008602 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 693974008603 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 693974008604 NADP binding site [chemical binding]; other site 693974008605 active site 693974008606 putative substrate binding site [chemical binding]; other site 693974008607 putative hydrolase; Validated; Region: PRK09248 693974008608 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 693974008609 active site 693974008610 SWIM zinc finger; Region: SWIM; pfam04434 693974008611 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 693974008612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693974008613 ATP binding site [chemical binding]; other site 693974008614 putative Mg++ binding site [ion binding]; other site 693974008615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974008616 nucleotide binding region [chemical binding]; other site 693974008617 ATP-binding site [chemical binding]; other site 693974008618 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 693974008619 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693974008620 DNA-binding site [nucleotide binding]; DNA binding site 693974008621 RNA-binding motif; other site 693974008622 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 693974008623 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 693974008624 TrkA-N domain; Region: TrkA_N; pfam02254 693974008625 TrkA-C domain; Region: TrkA_C; pfam02080 693974008626 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974008627 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974008628 metal binding site [ion binding]; metal-binding site 693974008629 active site 693974008630 I-site; other site 693974008631 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 693974008632 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 693974008633 Ligand Binding Site [chemical binding]; other site 693974008634 TilS substrate binding domain; Region: TilS; pfam09179 693974008635 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 693974008636 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 693974008637 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 693974008638 putative active site [active] 693974008639 putative PHP Thumb interface [polypeptide binding]; other site 693974008640 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 693974008641 generic binding surface II; other site 693974008642 generic binding surface I; other site 693974008643 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 693974008644 RNA/DNA hybrid binding site [nucleotide binding]; other site 693974008645 active site 693974008646 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 693974008647 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 693974008648 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 693974008649 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 693974008650 active site 693974008651 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 693974008652 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 693974008653 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 693974008654 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 693974008655 trimer interface [polypeptide binding]; other site 693974008656 active site 693974008657 UDP-GlcNAc binding site [chemical binding]; other site 693974008658 lipid binding site [chemical binding]; lipid-binding site 693974008659 periplasmic chaperone; Provisional; Region: PRK10780 693974008660 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 693974008661 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 693974008662 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693974008663 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693974008664 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693974008665 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693974008666 Surface antigen; Region: Bac_surface_Ag; pfam01103 693974008667 zinc metallopeptidase RseP; Provisional; Region: PRK10779 693974008668 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 693974008669 active site 693974008670 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 693974008671 protein binding site [polypeptide binding]; other site 693974008672 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 693974008673 protein binding site [polypeptide binding]; other site 693974008674 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 693974008675 putative substrate binding region [chemical binding]; other site 693974008676 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 693974008677 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 693974008678 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 693974008679 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 693974008680 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 693974008681 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 693974008682 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 693974008683 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 693974008684 catalytic residue [active] 693974008685 putative FPP diphosphate binding site; other site 693974008686 putative FPP binding hydrophobic cleft; other site 693974008687 dimer interface [polypeptide binding]; other site 693974008688 putative IPP diphosphate binding site; other site 693974008689 ribosome recycling factor; Reviewed; Region: frr; PRK00083 693974008690 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 693974008691 hinge region; other site 693974008692 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 693974008693 putative nucleotide binding site [chemical binding]; other site 693974008694 uridine monophosphate binding site [chemical binding]; other site 693974008695 homohexameric interface [polypeptide binding]; other site 693974008696 elongation factor Ts; Provisional; Region: tsf; PRK09377 693974008697 UBA/TS-N domain; Region: UBA; pfam00627 693974008698 Elongation factor TS; Region: EF_TS; pfam00889 693974008699 Elongation factor TS; Region: EF_TS; pfam00889 693974008700 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 693974008701 rRNA interaction site [nucleotide binding]; other site 693974008702 S8 interaction site; other site 693974008703 putative laminin-1 binding site; other site 693974008704 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 693974008705 active site 693974008706 PII uridylyl-transferase; Provisional; Region: PRK05007 693974008707 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 693974008708 metal binding triad; other site 693974008709 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 693974008710 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 693974008711 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 693974008712 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 693974008713 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 693974008714 trimer interface [polypeptide binding]; other site 693974008715 active site 693974008716 substrate binding site [chemical binding]; other site 693974008717 CoA binding site [chemical binding]; other site 693974008718 PAS domain; Region: PAS_9; pfam13426 693974008719 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693974008720 GAF domain; Region: GAF; pfam01590 693974008721 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 693974008722 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693974008723 Zn2+ binding site [ion binding]; other site 693974008724 Mg2+ binding site [ion binding]; other site 693974008725 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693974008726 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693974008727 FOG: CBS domain [General function prediction only]; Region: COG0517 693974008728 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 693974008729 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 693974008730 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 693974008731 putative active site [active] 693974008732 putative substrate binding site [chemical binding]; other site 693974008733 putative cosubstrate binding site; other site 693974008734 catalytic site [active] 693974008735 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 693974008736 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693974008737 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693974008738 active site turn [active] 693974008739 phosphorylation site [posttranslational modification] 693974008740 flavodoxin; Provisional; Region: PRK08105 693974008741 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693974008742 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 693974008743 probable active site [active] 693974008744 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 693974008745 Protein of unknown function (DUF3549); Region: DUF3549; pfam12069 693974008746 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 693974008747 Protein of unknown function (DUF962); Region: DUF962; pfam06127 693974008748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693974008749 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 693974008750 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 693974008751 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071 693974008752 SecY interacting protein Syd; Provisional; Region: PRK04968 693974008753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 693974008754 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 693974008755 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 693974008756 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 693974008757 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974008758 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 693974008759 putative substrate binding pocket [chemical binding]; other site 693974008760 putative dimerization interface [polypeptide binding]; other site 693974008761 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 693974008762 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693974008763 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 693974008764 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 693974008765 Winged helix-turn helix; Region: HTH_29; pfam13551 693974008766 Homeodomain-like domain; Region: HTH_23; pfam13384 693974008767 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 693974008768 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 693974008769 active site 693974008770 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 693974008771 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 693974008772 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693974008773 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693974008774 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693974008775 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693974008776 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 693974008777 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 693974008778 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 693974008779 putative NADP binding site [chemical binding]; other site 693974008780 active site 693974008781 Acyl transferase domain; Region: Acyl_transf_1; cl08282 693974008782 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 693974008783 3-oxoacyl-[acyl-carrier-protein] synthase; Region: PLN02836 693974008784 active site 693974008785 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 693974008786 active site 693974008787 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 693974008788 active site 2 [active] 693974008789 dimer interface [polypeptide binding]; other site 693974008790 active site 1 [active] 693974008791 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 693974008792 active site 1 [active] 693974008793 dimer interface [polypeptide binding]; other site 693974008794 active site 2 [active] 693974008795 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 693974008796 FMN binding site [chemical binding]; other site 693974008797 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 693974008798 substrate binding site [chemical binding]; other site 693974008799 putative catalytic residue [active] 693974008800 hypothetical protein; Provisional; Region: PRK12361 693974008801 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 693974008802 active site 693974008803 catalytic residues [active] 693974008804 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 693974008805 Major royal jelly protein; Region: MRJP; pfam03022 693974008806 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 693974008807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974008808 Walker A motif; other site 693974008809 ATP binding site [chemical binding]; other site 693974008810 Walker B motif; other site 693974008811 arginine finger; other site 693974008812 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693974008813 BON domain; Region: BON; pfam04972 693974008814 BON domain; Region: BON; pfam04972 693974008815 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 693974008816 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 693974008817 Putative catalytic NodB homology domain of uncharacterized Mll8295 protein encoded from Rhizobium loti and its bacterial homologs; Region: CE4_Mll8295_like; cd10946 693974008818 NodB motif; other site 693974008819 putative active site [active] 693974008820 putative catalytic site [active] 693974008821 putative Zn binding site [ion binding]; other site 693974008822 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 693974008823 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 693974008824 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974008825 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974008826 ligand-binding site [chemical binding]; other site 693974008827 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 693974008828 Helix-turn-helix domain; Region: HTH_18; pfam12833 693974008829 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 693974008830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974008831 putative substrate translocation pore; other site 693974008832 L-fucose transporter; Provisional; Region: PRK10133; cl17665 693974008833 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693974008834 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693974008835 nucleotide binding site [chemical binding]; other site 693974008836 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 693974008837 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 693974008838 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 693974008839 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 693974008840 active site 693974008841 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 693974008842 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 693974008843 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693974008844 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693974008845 ligand binding site [chemical binding]; other site 693974008846 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693974008847 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693974008848 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974008849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974008850 dimerization interface [polypeptide binding]; other site 693974008851 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974008852 dimer interface [polypeptide binding]; other site 693974008853 putative CheW interface [polypeptide binding]; other site 693974008854 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 693974008855 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 693974008856 putative active site [active] 693974008857 Zn binding site [ion binding]; other site 693974008858 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693974008859 MarR family; Region: MarR; pfam01047 693974008860 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 693974008861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974008862 putative substrate translocation pore; other site 693974008863 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 693974008864 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 693974008865 PhnA protein; Region: PhnA; pfam03831 693974008866 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 693974008867 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974008868 N-terminal plug; other site 693974008869 ligand-binding site [chemical binding]; other site 693974008870 TIGR02453 family protein; Region: TIGR02453 693974008871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693974008872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974008873 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693974008874 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 693974008875 putative C-terminal domain interface [polypeptide binding]; other site 693974008876 putative GSH binding site (G-site) [chemical binding]; other site 693974008877 putative dimer interface [polypeptide binding]; other site 693974008878 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 693974008879 putative N-terminal domain interface [polypeptide binding]; other site 693974008880 putative dimer interface [polypeptide binding]; other site 693974008881 putative substrate binding pocket (H-site) [chemical binding]; other site 693974008882 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 693974008883 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 693974008884 C-terminal domain interface [polypeptide binding]; other site 693974008885 GSH binding site (G-site) [chemical binding]; other site 693974008886 dimer interface [polypeptide binding]; other site 693974008887 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 693974008888 N-terminal domain interface [polypeptide binding]; other site 693974008889 putative dimer interface [polypeptide binding]; other site 693974008890 active site 693974008891 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 693974008892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974008893 S-adenosylmethionine binding site [chemical binding]; other site 693974008894 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 693974008895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693974008896 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 693974008897 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 693974008898 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974008899 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974008900 metal binding site [ion binding]; metal-binding site 693974008901 active site 693974008902 I-site; other site 693974008903 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693974008904 EamA-like transporter family; Region: EamA; pfam00892 693974008905 YfaZ precursor; Region: YfaZ; pfam07437 693974008906 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 693974008907 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693974008908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974008909 Coenzyme A binding pocket [chemical binding]; other site 693974008910 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 693974008911 MgtE intracellular N domain; Region: MgtE_N; smart00924 693974008912 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 693974008913 Divalent cation transporter; Region: MgtE; cl00786 693974008914 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 693974008915 catalytic residues [active] 693974008916 dimer interface [polypeptide binding]; other site 693974008917 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 693974008918 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 693974008919 active site 693974008920 Zn binding site [ion binding]; other site 693974008921 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 693974008922 PBP superfamily domain; Region: PBP_like_2; cl17296 693974008923 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 693974008924 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 693974008925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974008926 putative active site [active] 693974008927 heme pocket [chemical binding]; other site 693974008928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974008929 dimer interface [polypeptide binding]; other site 693974008930 phosphorylation site [posttranslational modification] 693974008931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974008932 ATP binding site [chemical binding]; other site 693974008933 Mg2+ binding site [ion binding]; other site 693974008934 G-X-G motif; other site 693974008935 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 693974008936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974008937 active site 693974008938 phosphorylation site [posttranslational modification] 693974008939 intermolecular recognition site; other site 693974008940 dimerization interface [polypeptide binding]; other site 693974008941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974008942 DNA binding site [nucleotide binding] 693974008943 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 693974008944 trimer interface [polypeptide binding]; other site 693974008945 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 693974008946 eyelet of channel; other site 693974008947 recombination associated protein; Reviewed; Region: rdgC; PRK00321 693974008948 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 693974008949 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 693974008950 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 693974008951 protein binding site [polypeptide binding]; other site 693974008952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974008953 TPR motif; other site 693974008954 binding surface 693974008955 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693974008956 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693974008957 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974008958 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974008959 metal binding site [ion binding]; metal-binding site 693974008960 active site 693974008961 I-site; other site 693974008962 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 693974008963 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 693974008964 flap endonuclease-like protein; Provisional; Region: PRK09482 693974008965 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 693974008966 active site 693974008967 metal binding site 1 [ion binding]; metal-binding site 693974008968 putative 5' ssDNA interaction site; other site 693974008969 metal binding site 3; metal-binding site 693974008970 metal binding site 2 [ion binding]; metal-binding site 693974008971 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 693974008972 putative DNA binding site [nucleotide binding]; other site 693974008973 putative metal binding site [ion binding]; other site 693974008974 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 693974008975 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693974008976 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693974008977 isocitrate dehydrogenase; Provisional; Region: PRK08997 693974008978 tartrate dehydrogenase; Region: TTC; TIGR02089 693974008979 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 693974008980 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 693974008981 Protein of unknown function (DUF423); Region: DUF423; pfam04241 693974008982 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 693974008983 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 693974008984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974008985 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 693974008986 dimerization interface [polypeptide binding]; other site 693974008987 substrate binding pocket [chemical binding]; other site 693974008988 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 693974008989 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 693974008990 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 693974008991 Ligand Binding Site [chemical binding]; other site 693974008992 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693974008993 active site residue [active] 693974008994 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 693974008995 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 693974008996 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693974008997 ligand binding site [chemical binding]; other site 693974008998 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 693974008999 flagellar motor protein PomA; Reviewed; Region: PRK08990 693974009000 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 693974009001 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 693974009002 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693974009003 substrate binding pocket [chemical binding]; other site 693974009004 chain length determination region; other site 693974009005 substrate-Mg2+ binding site; other site 693974009006 catalytic residues [active] 693974009007 aspartate-rich region 1; other site 693974009008 active site lid residues [active] 693974009009 aspartate-rich region 2; other site 693974009010 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 693974009011 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 693974009012 TPP-binding site; other site 693974009013 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693974009014 PYR/PP interface [polypeptide binding]; other site 693974009015 dimer interface [polypeptide binding]; other site 693974009016 TPP binding site [chemical binding]; other site 693974009017 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693974009018 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 693974009019 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 693974009020 dimer interface [polypeptide binding]; other site 693974009021 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 693974009022 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 693974009023 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 693974009024 L-lactate permease; Region: Lactate_perm; cl00701 693974009025 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 693974009026 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693974009027 FAD binding domain; Region: FAD_binding_4; pfam01565 693974009028 4Fe-4S binding domain; Region: Fer4; pfam00037 693974009029 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 693974009030 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 693974009031 Cysteine-rich domain; Region: CCG; pfam02754 693974009032 Cysteine-rich domain; Region: CCG; pfam02754 693974009033 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 693974009034 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 693974009035 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693974009036 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 693974009037 This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein; Region: BCS1_N; smart01024 693974009038 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 693974009039 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 693974009040 dimer interface [polypeptide binding]; other site 693974009041 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693974009042 ligand binding site [chemical binding]; other site 693974009043 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693974009044 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 693974009045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974009046 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693974009047 putative substrate translocation pore; other site 693974009048 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 693974009049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974009050 substrate binding pocket [chemical binding]; other site 693974009051 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974009052 membrane-bound complex binding site; other site 693974009053 hinge residues; other site 693974009054 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693974009055 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 693974009056 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693974009057 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 693974009058 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693974009059 ATP binding site [chemical binding]; other site 693974009060 Mg++ binding site [ion binding]; other site 693974009061 motif III; other site 693974009062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974009063 nucleotide binding region [chemical binding]; other site 693974009064 ATP-binding site [chemical binding]; other site 693974009065 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693974009066 PAS domain S-box; Region: sensory_box; TIGR00229 693974009067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974009068 putative active site [active] 693974009069 heme pocket [chemical binding]; other site 693974009070 PAS fold; Region: PAS_3; pfam08447 693974009071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974009072 PAS domain; Region: PAS_9; pfam13426 693974009073 putative active site [active] 693974009074 heme pocket [chemical binding]; other site 693974009075 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974009076 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974009077 metal binding site [ion binding]; metal-binding site 693974009078 active site 693974009079 I-site; other site 693974009080 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974009081 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 693974009082 glycogen synthase; Provisional; Region: glgA; PRK00654 693974009083 ADP-binding pocket [chemical binding]; other site 693974009084 homodimer interface [polypeptide binding]; other site 693974009085 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 693974009086 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 693974009087 ligand binding site; other site 693974009088 oligomer interface; other site 693974009089 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 693974009090 dimer interface [polypeptide binding]; other site 693974009091 N-terminal domain interface [polypeptide binding]; other site 693974009092 sulfate 1 binding site; other site 693974009093 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 693974009094 homodimer interface [polypeptide binding]; other site 693974009095 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 693974009096 active site pocket [active] 693974009097 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 693974009098 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 693974009099 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 693974009100 active site 693974009101 catalytic site [active] 693974009102 glycogen branching enzyme; Provisional; Region: PRK05402 693974009103 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 693974009104 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 693974009105 active site 693974009106 catalytic site [active] 693974009107 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 693974009108 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 693974009109 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 693974009110 active site 693974009111 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693974009112 MarR family; Region: MarR; pfam01047 693974009113 MarR family; Region: MarR_2; cl17246 693974009114 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 693974009115 BCCT family transporter; Region: BCCT; cl00569 693974009116 choline dehydrogenase; Validated; Region: PRK02106 693974009117 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 693974009118 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 693974009119 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693974009120 NAD(P) binding site [chemical binding]; other site 693974009121 catalytic residues [active] 693974009122 transcriptional regulator BetI; Validated; Region: PRK00767 693974009123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974009124 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 693974009125 putative alcohol dehydrogenase; Provisional; Region: PRK09860 693974009126 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 693974009127 dimer interface [polypeptide binding]; other site 693974009128 active site 693974009129 metal binding site [ion binding]; metal-binding site 693974009130 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 693974009131 isocitrate lyase; Provisional; Region: PRK15063 693974009132 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693974009133 tetramer interface [polypeptide binding]; other site 693974009134 active site 693974009135 Mg2+/Mn2+ binding site [ion binding]; other site 693974009136 malate synthase A; Region: malate_syn_A; TIGR01344 693974009137 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 693974009138 active site 693974009139 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693974009140 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974009141 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974009142 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 693974009143 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 693974009144 TrkA-N domain; Region: TrkA_N; pfam02254 693974009145 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974009146 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974009147 metal binding site [ion binding]; metal-binding site 693974009148 active site 693974009149 I-site; other site 693974009150 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 693974009151 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 693974009152 active site 693974009153 SAM binding site [chemical binding]; other site 693974009154 homodimer interface [polypeptide binding]; other site 693974009155 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 693974009156 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 693974009157 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 693974009158 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 693974009159 putative coenzyme Q binding site [chemical binding]; other site 693974009160 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 693974009161 SmpB-tmRNA interface; other site 693974009162 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693974009163 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693974009164 ATP binding site [chemical binding]; other site 693974009165 Mg++ binding site [ion binding]; other site 693974009166 motif III; other site 693974009167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974009168 nucleotide binding region [chemical binding]; other site 693974009169 ATP-binding site [chemical binding]; other site 693974009170 PAS domain; Region: PAS_9; pfam13426 693974009171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974009172 PAS domain; Region: PAS_9; pfam13426 693974009173 putative active site [active] 693974009174 heme pocket [chemical binding]; other site 693974009175 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974009176 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974009177 metal binding site [ion binding]; metal-binding site 693974009178 active site 693974009179 I-site; other site 693974009180 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974009181 AAA domain; Region: AAA_32; pfam13654 693974009182 ATP-dependent protease Lon; Provisional; Region: PRK13765 693974009183 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693974009184 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693974009185 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 693974009186 FMN binding site [chemical binding]; other site 693974009187 active site 693974009188 substrate binding site [chemical binding]; other site 693974009189 catalytic residue [active] 693974009190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693974009191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974009192 Protein of unknown function (DUF2375); Region: DUF2375; pfam09558 693974009193 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974009194 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974009195 dimer interface [polypeptide binding]; other site 693974009196 putative CheW interface [polypeptide binding]; other site 693974009197 hypothetical protein; Provisional; Region: PRK12378 693974009198 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 693974009199 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 693974009200 Histidine kinase; Region: HisKA_3; pfam07730 693974009201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974009202 ATP binding site [chemical binding]; other site 693974009203 Mg2+ binding site [ion binding]; other site 693974009204 G-X-G motif; other site 693974009205 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693974009206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974009207 active site 693974009208 phosphorylation site [posttranslational modification] 693974009209 intermolecular recognition site; other site 693974009210 dimerization interface [polypeptide binding]; other site 693974009211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693974009212 dimerization interface [polypeptide binding]; other site 693974009213 DNA binding residues [nucleotide binding] 693974009214 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693974009215 30S subunit binding site; other site 693974009216 PAS domain; Region: PAS_9; pfam13426 693974009217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974009218 putative active site [active] 693974009219 heme pocket [chemical binding]; other site 693974009220 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974009221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974009222 dimer interface [polypeptide binding]; other site 693974009223 putative CheW interface [polypeptide binding]; other site 693974009224 Protein of unknown function (DUF3649); Region: DUF3649; pfam12365 693974009225 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 693974009226 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 693974009227 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 693974009228 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 693974009229 OsmC-like protein; Region: OsmC; cl00767 693974009230 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 693974009231 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693974009232 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693974009233 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 693974009234 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 693974009235 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 693974009236 protein binding site [polypeptide binding]; other site 693974009237 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 693974009238 Domain interface; other site 693974009239 Peptide binding site; other site 693974009240 Active site tetrad [active] 693974009241 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974009242 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974009243 substrate binding pocket [chemical binding]; other site 693974009244 membrane-bound complex binding site; other site 693974009245 hinge residues; other site 693974009246 threonine synthase; Validated; Region: PRK09225 693974009247 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 693974009248 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693974009249 catalytic residue [active] 693974009250 homoserine kinase; Provisional; Region: PRK01212 693974009251 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693974009252 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 693974009253 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 693974009254 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 693974009255 putative catalytic residues [active] 693974009256 putative nucleotide binding site [chemical binding]; other site 693974009257 putative aspartate binding site [chemical binding]; other site 693974009258 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 693974009259 dimer interface [polypeptide binding]; other site 693974009260 putative threonine allosteric regulatory site; other site 693974009261 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 693974009262 putative threonine allosteric regulatory site; other site 693974009263 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 693974009264 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 693974009265 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 693974009266 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693974009267 Trp repressor protein; Region: Trp_repressor; pfam01371 693974009268 Cytochrome C' Region: Cytochrom_C_2; pfam01322 693974009269 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 693974009270 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693974009271 30S subunit binding site; other site 693974009272 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 693974009273 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 693974009274 Prephenate dehydratase; Region: PDT; pfam00800 693974009275 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 693974009276 putative L-Phe binding site [chemical binding]; other site 693974009277 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 693974009278 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 693974009279 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 693974009280 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 693974009281 FAD binding pocket [chemical binding]; other site 693974009282 FAD binding motif [chemical binding]; other site 693974009283 phosphate binding motif [ion binding]; other site 693974009284 beta-alpha-beta structure motif; other site 693974009285 NAD binding pocket [chemical binding]; other site 693974009286 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693974009287 catalytic loop [active] 693974009288 iron binding site [ion binding]; other site 693974009289 hybrid cluster protein; Provisional; Region: PRK05290 693974009290 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693974009291 ACS interaction site; other site 693974009292 CODH interaction site; other site 693974009293 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 693974009294 hybrid metal cluster; other site 693974009295 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 693974009296 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 693974009297 prephenate dehydrogenase; Validated; Region: PRK08507 693974009298 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 693974009299 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693974009300 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 693974009301 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 693974009302 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 693974009303 RimM N-terminal domain; Region: RimM; pfam01782 693974009304 PRC-barrel domain; Region: PRC; pfam05239 693974009305 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 693974009306 signal recognition particle protein; Provisional; Region: PRK10867 693974009307 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 693974009308 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 693974009309 P loop; other site 693974009310 GTP binding site [chemical binding]; other site 693974009311 Signal peptide binding domain; Region: SRP_SPB; pfam02978 693974009312 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 693974009313 Domain of unknown function DUF21; Region: DUF21; pfam01595 693974009314 hypothetical protein; Provisional; Region: PRK11573 693974009315 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693974009316 Transporter associated domain; Region: CorC_HlyC; smart01091 693974009317 Protein of unknown function (DUF962); Region: DUF962; cl01879 693974009318 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 693974009319 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 693974009320 active site 693974009321 hydrophilic channel; other site 693974009322 dimerization interface [polypeptide binding]; other site 693974009323 catalytic residues [active] 693974009324 active site lid [active] 693974009325 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 693974009326 Recombination protein O N terminal; Region: RecO_N; pfam11967 693974009327 Recombination protein O C terminal; Region: RecO_C; pfam02565 693974009328 GTPase Era; Reviewed; Region: era; PRK00089 693974009329 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 693974009330 G1 box; other site 693974009331 GTP/Mg2+ binding site [chemical binding]; other site 693974009332 Switch I region; other site 693974009333 G2 box; other site 693974009334 Switch II region; other site 693974009335 G3 box; other site 693974009336 G4 box; other site 693974009337 G5 box; other site 693974009338 KH domain; Region: KH_2; pfam07650 693974009339 ribonuclease III; Reviewed; Region: rnc; PRK00102 693974009340 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 693974009341 dimerization interface [polypeptide binding]; other site 693974009342 active site 693974009343 metal binding site [ion binding]; metal-binding site 693974009344 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 693974009345 dsRNA binding site [nucleotide binding]; other site 693974009346 signal peptidase I; Provisional; Region: PRK10861 693974009347 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693974009348 Catalytic site [active] 693974009349 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693974009350 GTP-binding protein LepA; Provisional; Region: PRK05433 693974009351 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 693974009352 G1 box; other site 693974009353 putative GEF interaction site [polypeptide binding]; other site 693974009354 GTP/Mg2+ binding site [chemical binding]; other site 693974009355 Switch I region; other site 693974009356 G2 box; other site 693974009357 G3 box; other site 693974009358 Switch II region; other site 693974009359 G4 box; other site 693974009360 G5 box; other site 693974009361 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 693974009362 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 693974009363 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 693974009364 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 693974009365 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 693974009366 anti-sigma E factor; Provisional; Region: rseB; PRK09455 693974009367 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 693974009368 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 693974009369 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 693974009370 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 693974009371 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693974009372 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693974009373 DNA binding residues [nucleotide binding] 693974009374 L-aspartate oxidase; Provisional; Region: PRK09077 693974009375 L-aspartate oxidase; Provisional; Region: PRK06175 693974009376 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693974009377 Uncharacterized conserved protein [Function unknown]; Region: COG2938 693974009378 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 693974009379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974009380 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693974009381 dimerization interface [polypeptide binding]; other site 693974009382 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 693974009383 thymidylate synthase; Reviewed; Region: thyA; PRK01827 693974009384 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 693974009385 dimerization interface [polypeptide binding]; other site 693974009386 active site 693974009387 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 693974009388 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693974009389 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 693974009390 GAF domain; Region: GAF; pfam01590 693974009391 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 693974009392 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693974009393 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693974009394 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 693974009395 putative active site [active] 693974009396 Ap4A binding site [chemical binding]; other site 693974009397 nudix motif; other site 693974009398 putative metal binding site [ion binding]; other site 693974009399 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 693974009400 putative DNA-binding cleft [nucleotide binding]; other site 693974009401 putative DNA clevage site; other site 693974009402 molecular lever; other site 693974009403 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693974009404 cyclase homology domain; Region: CHD; cd07302 693974009405 nucleotidyl binding site; other site 693974009406 metal binding site [ion binding]; metal-binding site 693974009407 dimer interface [polypeptide binding]; other site 693974009408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974009409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974009410 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 693974009411 dimerization interface [polypeptide binding]; other site 693974009412 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693974009413 putative binding surface; other site 693974009414 active site 693974009415 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 693974009416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974009417 FeS/SAM binding site; other site 693974009418 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 693974009419 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 693974009420 active site 693974009421 dimer interface [polypeptide binding]; other site 693974009422 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 693974009423 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 693974009424 active site 693974009425 FMN binding site [chemical binding]; other site 693974009426 substrate binding site [chemical binding]; other site 693974009427 3Fe-4S cluster binding site [ion binding]; other site 693974009428 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 693974009429 domain interface; other site 693974009430 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 693974009431 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693974009432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693974009433 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693974009434 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 693974009435 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 693974009436 Cobalamin biosynthesis protein CobD/CbiB [Coenzyme metabolism]; Region: CbiB; COG1270 693974009437 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 693974009438 hypothetical protein; Provisional; Region: PRK10578 693974009439 UPF0126 domain; Region: UPF0126; pfam03458 693974009440 UPF0126 domain; Region: UPF0126; pfam03458 693974009441 SnoaL-like domain; Region: SnoaL_2; pfam12680 693974009442 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 693974009443 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 693974009444 active site 693974009445 HIGH motif; other site 693974009446 dimer interface [polypeptide binding]; other site 693974009447 KMSKS motif; other site 693974009448 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693974009449 RNA binding surface [nucleotide binding]; other site 693974009450 putative peptidase; Provisional; Region: PRK11649 693974009451 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 693974009452 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 693974009453 Peptidase family M23; Region: Peptidase_M23; pfam01551 693974009454 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 693974009455 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 693974009456 amphipathic channel; other site 693974009457 Asn-Pro-Ala signature motifs; other site 693974009458 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 693974009459 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 693974009460 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 693974009461 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 693974009462 Cl- selectivity filter; other site 693974009463 Cl- binding residues [ion binding]; other site 693974009464 pore gating glutamate residue; other site 693974009465 dimer interface [polypeptide binding]; other site 693974009466 aspartate carbamoyltransferase; Provisional; Region: PRK08192 693974009467 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693974009468 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693974009469 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 693974009470 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693974009471 inhibitor-cofactor binding pocket; inhibition site 693974009472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974009473 catalytic residue [active] 693974009474 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 693974009475 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 693974009476 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 693974009477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974009478 Walker A motif; other site 693974009479 ATP binding site [chemical binding]; other site 693974009480 Walker B motif; other site 693974009481 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693974009482 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 693974009483 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 693974009484 active site 693974009485 NTP binding site [chemical binding]; other site 693974009486 metal binding triad [ion binding]; metal-binding site 693974009487 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 693974009488 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693974009489 Zn2+ binding site [ion binding]; other site 693974009490 Mg2+ binding site [ion binding]; other site 693974009491 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 693974009492 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 693974009493 Methyltransferase domain; Region: Methyltransf_11; pfam08241 693974009494 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 693974009495 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 693974009496 catalytic center binding site [active] 693974009497 ATP binding site [chemical binding]; other site 693974009498 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 693974009499 homooctamer interface [polypeptide binding]; other site 693974009500 active site 693974009501 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 693974009502 UGMP family protein; Validated; Region: PRK09604 693974009503 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 693974009504 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 693974009505 Yqey-like protein; Region: YqeY; pfam09424 693974009506 DNA primase; Validated; Region: dnaG; PRK05667 693974009507 CHC2 zinc finger; Region: zf-CHC2; pfam01807 693974009508 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 693974009509 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 693974009510 active site 693974009511 metal binding site [ion binding]; metal-binding site 693974009512 interdomain interaction site; other site 693974009513 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 693974009514 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 693974009515 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 693974009516 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 693974009517 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 693974009518 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 693974009519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693974009520 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693974009521 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693974009522 DNA binding residues [nucleotide binding] 693974009523 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 693974009524 dimerization interface [polypeptide binding]; other site 693974009525 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974009526 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974009527 dimer interface [polypeptide binding]; other site 693974009528 putative CheW interface [polypeptide binding]; other site 693974009529 fructokinase; Reviewed; Region: PRK09557 693974009530 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693974009531 nucleotide binding site [chemical binding]; other site 693974009532 Acetokinase family; Region: Acetate_kinase; cl17229 693974009533 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 693974009534 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 693974009535 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 693974009536 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 693974009537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974009538 putative substrate translocation pore; other site 693974009539 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 693974009540 beta-galactosidase; Region: BGL; TIGR03356 693974009541 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 693974009542 putative symporter YagG; Provisional; Region: PRK09669 693974009543 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693974009544 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693974009545 DNA binding site [nucleotide binding] 693974009546 domain linker motif; other site 693974009547 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 693974009548 dimerization interface (closed form) [polypeptide binding]; other site 693974009549 ligand binding site [chemical binding]; other site 693974009550 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 693974009551 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974009552 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974009553 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974009554 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 693974009555 SapC; Region: SapC; pfam07277 693974009556 Cupin-like domain; Region: Cupin_8; pfam13621 693974009557 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 693974009558 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 693974009559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974009560 putative substrate translocation pore; other site 693974009561 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 693974009562 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 693974009563 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 693974009564 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693974009565 inhibitor-cofactor binding pocket; inhibition site 693974009566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974009567 catalytic residue [active] 693974009568 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 693974009569 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 693974009570 tetramerization interface [polypeptide binding]; other site 693974009571 NAD(P) binding site [chemical binding]; other site 693974009572 catalytic residues [active] 693974009573 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693974009574 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693974009575 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693974009576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974009577 dimer interface [polypeptide binding]; other site 693974009578 conserved gate region; other site 693974009579 putative PBP binding loops; other site 693974009580 ABC-ATPase subunit interface; other site 693974009581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974009582 dimer interface [polypeptide binding]; other site 693974009583 conserved gate region; other site 693974009584 putative PBP binding loops; other site 693974009585 ABC-ATPase subunit interface; other site 693974009586 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 693974009587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974009588 Walker A/P-loop; other site 693974009589 ATP binding site [chemical binding]; other site 693974009590 Q-loop/lid; other site 693974009591 ABC transporter signature motif; other site 693974009592 Walker B; other site 693974009593 D-loop; other site 693974009594 H-loop/switch region; other site 693974009595 TOBE domain; Region: TOBE_2; pfam08402 693974009596 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 693974009597 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693974009598 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 693974009599 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693974009600 Peptidase C26; Region: Peptidase_C26; pfam07722 693974009601 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 693974009602 catalytic triad [active] 693974009603 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 693974009604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974009605 non-specific DNA binding site [nucleotide binding]; other site 693974009606 salt bridge; other site 693974009607 sequence-specific DNA binding site [nucleotide binding]; other site 693974009608 Cupin domain; Region: Cupin_2; pfam07883 693974009609 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693974009610 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693974009611 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 693974009612 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 693974009613 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 693974009614 active site residue [active] 693974009615 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 693974009616 active site residue [active] 693974009617 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 693974009618 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 693974009619 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 693974009620 Nuclease-related domain; Region: NERD; pfam08378 693974009621 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693974009622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693974009623 Transposase; Region: HTH_Tnp_1; pfam01527 693974009624 putative transposase OrfB; Reviewed; Region: PHA02517 693974009625 HTH-like domain; Region: HTH_21; pfam13276 693974009626 Integrase core domain; Region: rve; pfam00665 693974009627 Integrase core domain; Region: rve_3; pfam13683 693974009628 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 693974009629 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 693974009630 NAD(P) binding site [chemical binding]; other site 693974009631 catalytic residues [active] 693974009632 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 693974009633 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693974009634 inhibitor-cofactor binding pocket; inhibition site 693974009635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974009636 catalytic residue [active] 693974009637 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 693974009638 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 693974009639 tetrameric interface [polypeptide binding]; other site 693974009640 NAD binding site [chemical binding]; other site 693974009641 catalytic residues [active] 693974009642 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 693974009643 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 693974009644 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 693974009645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974009646 putative substrate translocation pore; other site 693974009647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 693974009648 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 693974009649 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 693974009650 active site 693974009651 dimer interface [polypeptide binding]; other site 693974009652 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 693974009653 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 693974009654 dimer interface [polypeptide binding]; other site 693974009655 active site 693974009656 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693974009657 dimer interface [polypeptide binding]; other site 693974009658 active site 693974009659 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 693974009660 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 693974009661 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 693974009662 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 693974009663 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 693974009664 active site 693974009665 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 693974009666 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974009667 dimerization interface [polypeptide binding]; other site 693974009668 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974009669 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974009670 dimer interface [polypeptide binding]; other site 693974009671 putative CheW interface [polypeptide binding]; other site 693974009672 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974009673 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 693974009674 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693974009675 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 693974009676 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 693974009677 SapC; Region: SapC; pfam07277 693974009678 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 693974009679 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974009680 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974009681 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693974009682 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693974009683 DNA binding site [nucleotide binding] 693974009684 domain linker motif; other site 693974009685 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 693974009686 putative ligand binding site [chemical binding]; other site 693974009687 putative dimerization interface [polypeptide binding]; other site 693974009688 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 693974009689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693974009690 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 693974009691 Nitrogen regulatory protein P-II; Region: P-II; smart00938 693974009692 Type II transport protein GspH; Region: GspH; pfam12019 693974009693 Type II transport protein GspH; Region: GspH; pfam12019 693974009694 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 693974009695 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 693974009696 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 693974009697 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 693974009698 PilX N-terminal; Region: PilX_N; pfam14341 693974009699 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 693974009700 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 693974009701 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 693974009702 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 693974009703 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 693974009704 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 693974009705 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693974009706 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 693974009707 lipoprotein signal peptidase; Provisional; Region: PRK14787 693974009708 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 693974009709 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 693974009710 HIGH motif; other site 693974009711 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 693974009712 active site 693974009713 KMSKS motif; other site 693974009714 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 693974009715 tRNA binding surface [nucleotide binding]; other site 693974009716 anticodon binding site; other site 693974009717 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693974009718 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 693974009719 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 693974009720 active site 693974009721 Riboflavin kinase; Region: Flavokinase; smart00904 693974009722 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 693974009723 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 693974009724 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 693974009725 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693974009726 dimerization interface [polypeptide binding]; other site 693974009727 putative DNA binding site [nucleotide binding]; other site 693974009728 putative Zn2+ binding site [ion binding]; other site 693974009729 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693974009730 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 693974009731 PA/protease or protease-like domain interface [polypeptide binding]; other site 693974009732 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 693974009733 Peptidase family M28; Region: Peptidase_M28; pfam04389 693974009734 metal binding site [ion binding]; metal-binding site 693974009735 hypothetical protein; Validated; Region: PRK02101 693974009736 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693974009737 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 693974009738 putative phosphoketolase; Provisional; Region: PRK05261 693974009739 XFP N-terminal domain; Region: XFP_N; pfam09364 693974009740 XFP C-terminal domain; Region: XFP_C; pfam09363 693974009741 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693974009742 outer membrane protein A; Reviewed; Region: PRK10808 693974009743 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693974009744 ligand binding site [chemical binding]; other site 693974009745 transaldolase-like protein; Provisional; Region: PTZ00411 693974009746 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 693974009747 active site 693974009748 dimer interface [polypeptide binding]; other site 693974009749 catalytic residue [active] 693974009750 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 693974009751 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 693974009752 active site 693974009753 dimer interface [polypeptide binding]; other site 693974009754 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 693974009755 dimer interface [polypeptide binding]; other site 693974009756 active site 693974009757 Protein of unknown function (DUF3545); Region: DUF3545; pfam12065 693974009758 Hemerythrin-like domain; Region: Hr-like; cd12108 693974009759 Fe binding site [ion binding]; other site 693974009760 RNA polymerase sigma factor; Provisional; Region: PRK12513 693974009761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693974009762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693974009763 DNA binding residues [nucleotide binding] 693974009764 von Willebrand factor; Region: vWF_A; pfam12450 693974009765 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 693974009766 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 693974009767 metal ion-dependent adhesion site (MIDAS); other site 693974009768 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 693974009769 putative transporter; Provisional; Region: PRK11660 693974009770 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693974009771 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693974009772 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693974009773 AIR carboxylase; Region: AIRC; pfam00731 693974009774 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 693974009775 ATP-grasp domain; Region: ATP-grasp; pfam02222 693974009776 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693974009777 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 693974009778 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974009779 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974009780 metal binding site [ion binding]; metal-binding site 693974009781 active site 693974009782 I-site; other site 693974009783 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693974009784 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693974009785 catalytic residue [active] 693974009786 glutamate--cysteine ligase; Provisional; Region: PRK02107 693974009787 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693974009788 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693974009789 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693974009790 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693974009791 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693974009792 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693974009793 Predicted membrane protein [Function unknown]; Region: COG1238 693974009794 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693974009795 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693974009796 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 693974009797 oxaloacetate decarboxylase; Provisional; Region: PRK14040 693974009798 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 693974009799 active site 693974009800 catalytic residues [active] 693974009801 metal binding site [ion binding]; metal-binding site 693974009802 homodimer binding site [polypeptide binding]; other site 693974009803 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693974009804 carboxyltransferase (CT) interaction site; other site 693974009805 biotinylation site [posttranslational modification]; other site 693974009806 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 693974009807 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 693974009808 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 693974009809 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 693974009810 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 693974009811 Clp amino terminal domain; Region: Clp_N; pfam02861 693974009812 Clp amino terminal domain; Region: Clp_N; pfam02861 693974009813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974009814 Walker A motif; other site 693974009815 ATP binding site [chemical binding]; other site 693974009816 Walker B motif; other site 693974009817 arginine finger; other site 693974009818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974009819 Walker A motif; other site 693974009820 ATP binding site [chemical binding]; other site 693974009821 Walker B motif; other site 693974009822 arginine finger; other site 693974009823 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693974009824 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 693974009825 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 693974009826 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 693974009827 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693974009828 RNA binding surface [nucleotide binding]; other site 693974009829 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693974009830 active site 693974009831 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 693974009832 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 693974009833 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974009834 HAMP domain; Region: HAMP; pfam00672 693974009835 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974009836 dimer interface [polypeptide binding]; other site 693974009837 putative CheW interface [polypeptide binding]; other site 693974009838 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 693974009839 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 693974009840 heme-binding site [chemical binding]; other site 693974009841 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 693974009842 FAD binding pocket [chemical binding]; other site 693974009843 FAD binding motif [chemical binding]; other site 693974009844 phosphate binding motif [ion binding]; other site 693974009845 beta-alpha-beta structure motif; other site 693974009846 NAD binding pocket [chemical binding]; other site 693974009847 Heme binding pocket [chemical binding]; other site 693974009848 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 693974009849 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693974009850 RNA binding surface [nucleotide binding]; other site 693974009851 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 693974009852 active site 693974009853 uracil binding [chemical binding]; other site 693974009854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974009855 TPR motif; other site 693974009856 TPR repeat; Region: TPR_11; pfam13414 693974009857 binding surface 693974009858 Predicted transcriptional regulator [Transcription]; Region: COG2345 693974009859 Transcriptional regulator PadR-like family; Region: PadR; cl17335 693974009860 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693974009861 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 693974009862 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693974009863 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693974009864 active site 693974009865 metal binding site [ion binding]; metal-binding site 693974009866 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 693974009867 YcxB-like protein; Region: YcxB; pfam14317 693974009868 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 693974009869 MltA-interacting protein MipA; Region: MipA; cl01504 693974009870 Protein of unknown function (DUF3019); Region: DUF3019; pfam11456 693974009871 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 693974009872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974009873 active site 693974009874 phosphorylation site [posttranslational modification] 693974009875 intermolecular recognition site; other site 693974009876 dimerization interface [polypeptide binding]; other site 693974009877 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974009878 DNA binding site [nucleotide binding] 693974009879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974009880 dimer interface [polypeptide binding]; other site 693974009881 phosphorylation site [posttranslational modification] 693974009882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974009883 ATP binding site [chemical binding]; other site 693974009884 Mg2+ binding site [ion binding]; other site 693974009885 G-X-G motif; other site 693974009886 Predicted Fe-S protein [General function prediction only]; Region: COG3313 693974009887 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 693974009888 cysteine synthase B; Region: cysM; TIGR01138 693974009889 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693974009890 dimer interface [polypeptide binding]; other site 693974009891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974009892 catalytic residue [active] 693974009893 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150 693974009894 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693974009895 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693974009896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974009897 dimer interface [polypeptide binding]; other site 693974009898 conserved gate region; other site 693974009899 putative PBP binding loops; other site 693974009900 ABC-ATPase subunit interface; other site 693974009901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974009902 dimer interface [polypeptide binding]; other site 693974009903 conserved gate region; other site 693974009904 putative PBP binding loops; other site 693974009905 ABC-ATPase subunit interface; other site 693974009906 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 693974009907 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 693974009908 Walker A/P-loop; other site 693974009909 ATP binding site [chemical binding]; other site 693974009910 Q-loop/lid; other site 693974009911 ABC transporter signature motif; other site 693974009912 Walker B; other site 693974009913 D-loop; other site 693974009914 H-loop/switch region; other site 693974009915 TOBE-like domain; Region: TOBE_3; pfam12857 693974009916 Protein of unknown function DUF2625; Region: DUF2625; cl08177 693974009917 Ycf46; Provisional; Region: ycf46; CHL00195 693974009918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974009919 Walker A motif; other site 693974009920 ATP binding site [chemical binding]; other site 693974009921 Walker B motif; other site 693974009922 arginine finger; other site 693974009923 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693974009924 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974009925 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974009926 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 693974009927 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 693974009928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974009929 ATP-grasp domain; Region: ATP-grasp; pfam02222 693974009930 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693974009931 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693974009932 active site 693974009933 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693974009934 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 693974009935 glycerate dehydrogenase; Provisional; Region: PRK06487 693974009936 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 693974009937 putative ligand binding site [chemical binding]; other site 693974009938 putative NAD binding site [chemical binding]; other site 693974009939 catalytic site [active] 693974009940 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693974009941 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 693974009942 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 693974009943 putative metal binding site [ion binding]; other site 693974009944 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693974009945 HSP70 interaction site [polypeptide binding]; other site 693974009946 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 693974009947 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 693974009948 Substrate binding site; other site 693974009949 metal-binding site 693974009950 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 693974009951 Phosphotransferase enzyme family; Region: APH; pfam01636 693974009952 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 693974009953 OstA-like protein; Region: OstA; cl00844 693974009954 Organic solvent tolerance protein; Region: OstA_C; pfam04453 693974009955 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 693974009956 SurA N-terminal domain; Region: SurA_N; pfam09312 693974009957 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693974009958 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693974009959 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 693974009960 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 693974009961 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 693974009962 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 693974009963 S-adenosylmethionine binding site [chemical binding]; other site 693974009964 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 693974009965 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 693974009966 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 693974009967 active site 693974009968 metal binding site [ion binding]; metal-binding site 693974009969 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974009970 dimerization interface [polypeptide binding]; other site 693974009971 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974009972 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974009973 dimer interface [polypeptide binding]; other site 693974009974 putative CheW interface [polypeptide binding]; other site 693974009975 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 693974009976 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 693974009977 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 693974009978 NADP+ binding site [chemical binding]; other site 693974009979 folate binding site [chemical binding]; other site 693974009980 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 693974009981 Uncharacterized conserved protein [Function unknown]; Region: COG2966 693974009982 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 693974009983 GTPase CgtA; Reviewed; Region: obgE; PRK12298 693974009984 GTP1/OBG; Region: GTP1_OBG; pfam01018 693974009985 Obg GTPase; Region: Obg; cd01898 693974009986 G1 box; other site 693974009987 GTP/Mg2+ binding site [chemical binding]; other site 693974009988 Switch I region; other site 693974009989 G2 box; other site 693974009990 G3 box; other site 693974009991 Switch II region; other site 693974009992 G4 box; other site 693974009993 G5 box; other site 693974009994 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 693974009995 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 693974009996 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 693974009997 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 693974009998 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693974009999 substrate binding pocket [chemical binding]; other site 693974010000 chain length determination region; other site 693974010001 substrate-Mg2+ binding site; other site 693974010002 catalytic residues [active] 693974010003 aspartate-rich region 1; other site 693974010004 active site lid residues [active] 693974010005 aspartate-rich region 2; other site 693974010006 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 693974010007 ligand binding site [chemical binding]; other site 693974010008 active site 693974010009 UGI interface [polypeptide binding]; other site 693974010010 catalytic site [active] 693974010011 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 693974010012 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693974010013 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 693974010014 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 693974010015 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 693974010016 DsbD alpha interface [polypeptide binding]; other site 693974010017 catalytic residues [active] 693974010018 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974010019 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974010020 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974010021 PAS domain S-box; Region: sensory_box; TIGR00229 693974010022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974010023 putative active site [active] 693974010024 heme pocket [chemical binding]; other site 693974010025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974010026 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 693974010027 Walker A motif; other site 693974010028 ATP binding site [chemical binding]; other site 693974010029 Walker B motif; other site 693974010030 arginine finger; other site 693974010031 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693974010032 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 693974010033 4Fe-4S binding domain; Region: Fer4_5; pfam12801 693974010034 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 693974010035 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 693974010036 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 693974010037 acyl-activating enzyme (AAE) consensus motif; other site 693974010038 putative AMP binding site [chemical binding]; other site 693974010039 putative active site [active] 693974010040 putative CoA binding site [chemical binding]; other site 693974010041 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 693974010042 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693974010043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974010044 Walker A/P-loop; other site 693974010045 ATP binding site [chemical binding]; other site 693974010046 Q-loop/lid; other site 693974010047 ABC transporter signature motif; other site 693974010048 Walker B; other site 693974010049 D-loop; other site 693974010050 H-loop/switch region; other site 693974010051 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 693974010052 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 693974010053 Haem utilisation ChuX/HutX; Region: ChuX_HutX; pfam06228 693974010054 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 693974010055 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974010056 N-terminal plug; other site 693974010057 ligand-binding site [chemical binding]; other site 693974010058 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 693974010059 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693974010060 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 693974010061 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 693974010062 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 693974010063 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693974010064 putative hemin binding site; other site 693974010065 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693974010066 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693974010067 ABC-ATPase subunit interface; other site 693974010068 dimer interface [polypeptide binding]; other site 693974010069 putative PBP binding regions; other site 693974010070 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 693974010071 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693974010072 Walker A/P-loop; other site 693974010073 ATP binding site [chemical binding]; other site 693974010074 Q-loop/lid; other site 693974010075 ABC transporter signature motif; other site 693974010076 Walker B; other site 693974010077 D-loop; other site 693974010078 H-loop/switch region; other site 693974010079 Protein of unknown function (DUF2956); Region: DUF2956; pfam11169 693974010080 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693974010081 interface (dimer of trimers) [polypeptide binding]; other site 693974010082 Substrate-binding/catalytic site; other site 693974010083 Zn-binding sites [ion binding]; other site 693974010084 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 693974010085 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 693974010086 metal binding site [ion binding]; metal-binding site 693974010087 dimer interface [polypeptide binding]; other site 693974010088 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 693974010089 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974010090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974010091 dimerization interface [polypeptide binding]; other site 693974010092 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974010093 dimer interface [polypeptide binding]; other site 693974010094 putative CheW interface [polypeptide binding]; other site 693974010095 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693974010096 EamA-like transporter family; Region: EamA; pfam00892 693974010097 EamA-like transporter family; Region: EamA; pfam00892 693974010098 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974010099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974010100 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974010101 putative effector binding pocket; other site 693974010102 dimerization interface [polypeptide binding]; other site 693974010103 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 693974010104 active site 693974010105 DNA polymerase IV; Validated; Region: PRK02406 693974010106 DNA binding site [nucleotide binding] 693974010107 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974010108 dimerization interface [polypeptide binding]; other site 693974010109 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974010110 dimer interface [polypeptide binding]; other site 693974010111 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 693974010112 putative CheW interface [polypeptide binding]; other site 693974010113 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 693974010114 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 693974010115 heme binding site [chemical binding]; other site 693974010116 ferroxidase pore; other site 693974010117 ferroxidase diiron center [ion binding]; other site 693974010118 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 693974010119 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 693974010120 heme binding site [chemical binding]; other site 693974010121 ferroxidase pore; other site 693974010122 ferroxidase diiron center [ion binding]; other site 693974010123 Protein of unknown function (DUF539); Region: DUF539; cl01129 693974010124 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 693974010125 ApbE family; Region: ApbE; pfam02424 693974010126 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 693974010127 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 693974010128 FAD binding pocket [chemical binding]; other site 693974010129 FAD binding motif [chemical binding]; other site 693974010130 phosphate binding motif [ion binding]; other site 693974010131 beta-alpha-beta structure motif; other site 693974010132 NAD binding pocket [chemical binding]; other site 693974010133 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 693974010134 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 693974010135 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 693974010136 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 693974010137 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 693974010138 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 693974010139 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 693974010140 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974010141 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974010142 S-ribosylhomocysteinase; Provisional; Region: PRK02260 693974010143 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 693974010144 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 693974010145 BolA-like protein; Region: BolA; cl00386 693974010146 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 693974010147 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 693974010148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974010149 S-adenosylmethionine binding site [chemical binding]; other site 693974010150 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 693974010151 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 693974010152 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 693974010153 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693974010154 homodimer interface [polypeptide binding]; other site 693974010155 substrate-cofactor binding pocket; other site 693974010156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974010157 catalytic residue [active] 693974010158 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693974010159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693974010160 DNA-binding site [nucleotide binding]; DNA binding site 693974010161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693974010162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974010163 homodimer interface [polypeptide binding]; other site 693974010164 catalytic residue [active] 693974010165 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 693974010166 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 693974010167 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 693974010168 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 693974010169 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693974010170 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693974010171 Helix-turn-helix domain; Region: HTH_18; pfam12833 693974010172 EamA-like transporter family; Region: EamA; pfam00892 693974010173 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693974010174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974010175 dimerization interface [polypeptide binding]; other site 693974010176 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974010177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974010178 dimer interface [polypeptide binding]; other site 693974010179 putative CheW interface [polypeptide binding]; other site 693974010180 ApbE family; Region: ApbE; pfam02424 693974010181 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 693974010182 FMN-binding domain; Region: FMN_bind; pfam04205 693974010183 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 693974010184 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 693974010185 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693974010186 RNA binding surface [nucleotide binding]; other site 693974010187 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 693974010188 probable active site [active] 693974010189 endonuclease subunit; Provisional; Region: 46; PHA02562 693974010190 Peptidase S46; Region: Peptidase_S46; pfam10459 693974010191 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 693974010192 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 693974010193 aromatic amino acid transport protein; Region: araaP; TIGR00837 693974010194 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 693974010195 Chitin binding domain; Region: Chitin_bind_3; pfam03067 693974010196 Predicted membrane protein [Function unknown]; Region: COG2119 693974010197 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 693974010198 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 693974010199 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 693974010200 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 693974010201 tetramer interface [polypeptide binding]; other site 693974010202 heme binding pocket [chemical binding]; other site 693974010203 NADPH binding site [chemical binding]; other site 693974010204 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693974010205 CoenzymeA binding site [chemical binding]; other site 693974010206 subunit interaction site [polypeptide binding]; other site 693974010207 PHB binding site; other site 693974010208 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 693974010209 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 693974010210 generic binding surface II; other site 693974010211 generic binding surface I; other site 693974010212 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693974010213 putative catalytic site [active] 693974010214 putative metal binding site [ion binding]; other site 693974010215 putative phosphate binding site [ion binding]; other site 693974010216 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 693974010217 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 693974010218 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693974010219 FOG: WD40 repeat [General function prediction only]; Region: COG2319 693974010220 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 693974010221 structural tetrad; other site 693974010222 SlyX; Region: SlyX; pfam04102 693974010223 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693974010224 active site 693974010225 catalytic residues [active] 693974010226 metal binding site [ion binding]; metal-binding site 693974010227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 693974010228 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 693974010229 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 693974010230 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 693974010231 Zn binding site [ion binding]; other site 693974010232 Cache domain; Region: Cache_1; pfam02743 693974010233 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974010234 dimerization interface [polypeptide binding]; other site 693974010235 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974010236 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974010237 dimer interface [polypeptide binding]; other site 693974010238 putative CheW interface [polypeptide binding]; other site 693974010239 PAS domain S-box; Region: sensory_box; TIGR00229 693974010240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974010241 putative active site [active] 693974010242 heme pocket [chemical binding]; other site 693974010243 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693974010244 GAF domain; Region: GAF; pfam01590 693974010245 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974010246 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974010247 metal binding site [ion binding]; metal-binding site 693974010248 active site 693974010249 I-site; other site 693974010250 Protein of unknown function DUF72; Region: DUF72; cl00777 693974010251 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693974010252 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 693974010253 tetramer interface [polypeptide binding]; other site 693974010254 active site 693974010255 Mg2+/Mn2+ binding site [ion binding]; other site 693974010256 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693974010257 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693974010258 Cupin domain; Region: Cupin_2; cl17218 693974010259 Helix-turn-helix domain; Region: HTH_18; pfam12833 693974010260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974010261 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 693974010262 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 693974010263 catalytic triad [active] 693974010264 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 693974010265 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 693974010266 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693974010267 CoenzymeA binding site [chemical binding]; other site 693974010268 subunit interaction site [polypeptide binding]; other site 693974010269 PHB binding site; other site 693974010270 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 693974010271 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 693974010272 dimer interface [polypeptide binding]; other site 693974010273 active site 693974010274 heme binding site [chemical binding]; other site 693974010275 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 693974010276 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 693974010277 Carbon starvation protein CstA; Region: CstA; pfam02554 693974010278 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 693974010279 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 693974010280 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 693974010281 dimer interface [polypeptide binding]; other site 693974010282 putative anticodon binding site; other site 693974010283 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 693974010284 motif 1; other site 693974010285 active site 693974010286 motif 2; other site 693974010287 motif 3; other site 693974010288 peptide chain release factor 2; Validated; Region: prfB; PRK00578 693974010289 This domain is found in peptide chain release factors; Region: PCRF; smart00937 693974010290 RF-1 domain; Region: RF-1; pfam00472 693974010291 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 693974010292 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693974010293 catalytic loop [active] 693974010294 iron binding site [ion binding]; other site 693974010295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693974010296 4Fe-4S binding domain; Region: Fer4_6; pfam12837 693974010297 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693974010298 4Fe-4S binding domain; Region: Fer4; pfam00037 693974010299 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 693974010300 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 693974010301 [4Fe-4S] binding site [ion binding]; other site 693974010302 molybdopterin cofactor binding site; other site 693974010303 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 693974010304 molybdopterin cofactor binding site; other site 693974010305 Cache domain; Region: Cache_2; pfam08269 693974010306 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974010307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974010308 dimerization interface [polypeptide binding]; other site 693974010309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974010310 dimer interface [polypeptide binding]; other site 693974010311 putative CheW interface [polypeptide binding]; other site 693974010312 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 693974010313 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 693974010314 Chromate transporter; Region: Chromate_transp; pfam02417 693974010315 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 693974010316 FAD dependent oxidoreductase; Region: DAO; pfam01266 693974010317 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693974010318 MarR family; Region: MarR; pfam01047 693974010319 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 693974010320 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 693974010321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974010322 S-adenosylmethionine binding site [chemical binding]; other site 693974010323 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 693974010324 heme-binding residues [chemical binding]; other site 693974010325 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 693974010326 L-aspartate oxidase; Provisional; Region: PRK06175 693974010327 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 693974010328 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693974010329 putative ligand binding site [chemical binding]; other site 693974010330 putative NAD binding site [chemical binding]; other site 693974010331 catalytic site [active] 693974010332 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 693974010333 Domain of unknown function (DU1801); Region: DUF1801; cl17490 693974010334 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 693974010335 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974010336 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974010337 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974010338 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 693974010339 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 693974010340 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693974010341 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693974010342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974010343 multifunctional aminopeptidase A; Provisional; Region: PRK00913 693974010344 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 693974010345 interface (dimer of trimers) [polypeptide binding]; other site 693974010346 Substrate-binding/catalytic site; other site 693974010347 Zn-binding sites [ion binding]; other site 693974010348 peroxiredoxin; Region: AhpC; TIGR03137 693974010349 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 693974010350 dimer interface [polypeptide binding]; other site 693974010351 decamer (pentamer of dimers) interface [polypeptide binding]; other site 693974010352 catalytic triad [active] 693974010353 peroxidatic and resolving cysteines [active] 693974010354 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 693974010355 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 693974010356 catalytic residue [active] 693974010357 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 693974010358 catalytic residues [active] 693974010359 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693974010360 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693974010361 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 693974010362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974010363 Coenzyme A binding pocket [chemical binding]; other site 693974010364 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 693974010365 DHH family; Region: DHH; pfam01368 693974010366 DHHA1 domain; Region: DHHA1; pfam02272 693974010367 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 693974010368 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 693974010369 dimerization domain [polypeptide binding]; other site 693974010370 dimer interface [polypeptide binding]; other site 693974010371 catalytic residues [active] 693974010372 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 693974010373 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 693974010374 active site 693974010375 Int/Topo IB signature motif; other site 693974010376 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 693974010377 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 693974010378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974010379 S-adenosylmethionine binding site [chemical binding]; other site 693974010380 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693974010381 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693974010382 ATP binding site [chemical binding]; other site 693974010383 Mg++ binding site [ion binding]; other site 693974010384 motif III; other site 693974010385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974010386 nucleotide binding region [chemical binding]; other site 693974010387 ATP-binding site [chemical binding]; other site 693974010388 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693974010389 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974010390 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693974010391 Protein export membrane protein; Region: SecD_SecF; cl14618 693974010392 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 693974010393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974010394 FeS/SAM binding site; other site 693974010395 PAS domain; Region: PAS_9; pfam13426 693974010396 PAS domain; Region: PAS_9; pfam13426 693974010397 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974010398 I-site; other site 693974010399 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 693974010400 DNA binding site [nucleotide binding] 693974010401 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 693974010402 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 693974010403 Protein of unknown function, DUF481; Region: DUF481; pfam04338 693974010404 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 693974010405 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 693974010406 intersubunit interface [polypeptide binding]; other site 693974010407 active site 693974010408 zinc binding site [ion binding]; other site 693974010409 Na+ binding site [ion binding]; other site 693974010410 Phosphoglycerate kinase; Region: PGK; pfam00162 693974010411 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 693974010412 substrate binding site [chemical binding]; other site 693974010413 hinge regions; other site 693974010414 ADP binding site [chemical binding]; other site 693974010415 catalytic site [active] 693974010416 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 693974010417 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693974010418 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693974010419 transketolase; Reviewed; Region: PRK12753 693974010420 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693974010421 TPP-binding site [chemical binding]; other site 693974010422 dimer interface [polypeptide binding]; other site 693974010423 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693974010424 PYR/PP interface [polypeptide binding]; other site 693974010425 dimer interface [polypeptide binding]; other site 693974010426 TPP binding site [chemical binding]; other site 693974010427 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693974010428 S-adenosylmethionine synthetase; Validated; Region: PRK05250 693974010429 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 693974010430 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 693974010431 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 693974010432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974010433 Coenzyme A binding pocket [chemical binding]; other site 693974010434 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974010435 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974010436 metal binding site [ion binding]; metal-binding site 693974010437 active site 693974010438 I-site; other site 693974010439 META domain; Region: META; pfam03724 693974010440 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693974010441 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693974010442 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693974010443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974010444 Coenzyme A binding pocket [chemical binding]; other site 693974010445 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 693974010446 serine transporter; Region: stp; TIGR00814 693974010447 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 693974010448 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 693974010449 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 693974010450 active site 693974010451 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 693974010452 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 693974010453 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693974010454 MarR family; Region: MarR; pfam01047 693974010455 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693974010456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974010457 Coenzyme A binding pocket [chemical binding]; other site 693974010458 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 693974010459 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693974010460 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 693974010461 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693974010462 catalytic loop [active] 693974010463 iron binding site [ion binding]; other site 693974010464 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 693974010465 FAD binding pocket [chemical binding]; other site 693974010466 FAD binding motif [chemical binding]; other site 693974010467 phosphate binding motif [ion binding]; other site 693974010468 beta-alpha-beta structure motif; other site 693974010469 NAD binding pocket [chemical binding]; other site 693974010470 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 693974010471 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 693974010472 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 693974010473 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 693974010474 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 693974010475 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 693974010476 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 693974010477 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693974010478 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693974010479 active site 693974010480 catalytic tetrad [active] 693974010481 MltA-interacting protein MipA; Region: MipA; cl01504 693974010482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693974010483 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974010484 dimerization interface [polypeptide binding]; other site 693974010485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974010486 dimer interface [polypeptide binding]; other site 693974010487 phosphorylation site [posttranslational modification] 693974010488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974010489 ATP binding site [chemical binding]; other site 693974010490 Mg2+ binding site [ion binding]; other site 693974010491 G-X-G motif; other site 693974010492 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693974010493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974010494 active site 693974010495 phosphorylation site [posttranslational modification] 693974010496 intermolecular recognition site; other site 693974010497 dimerization interface [polypeptide binding]; other site 693974010498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974010499 DNA binding site [nucleotide binding] 693974010500 Protein of unknown function (DUF3019); Region: DUF3019; pfam11456 693974010501 MltA-interacting protein MipA; Region: MipA; cl01504 693974010502 Cna protein B-type domain; Region: Cna_B_2; pfam13715 693974010503 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974010504 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 693974010505 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693974010506 Helix-turn-helix domain; Region: HTH_38; pfam13936 693974010507 Integrase core domain; Region: rve; pfam00665 693974010508 Stringent starvation protein B; Region: SspB; cl01120 693974010509 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974010510 dimerization interface [polypeptide binding]; other site 693974010511 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974010512 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974010513 dimer interface [polypeptide binding]; other site 693974010514 putative CheW interface [polypeptide binding]; other site 693974010515 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 693974010516 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 693974010517 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693974010518 catalytic residue [active] 693974010519 Fe-S metabolism associated domain; Region: SufE; cl00951 693974010520 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693974010521 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 693974010522 active site 693974010523 Predicted ATPase [General function prediction only]; Region: COG4637 693974010524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974010525 Walker A/P-loop; other site 693974010526 ATP binding site [chemical binding]; other site 693974010527 Cupin domain; Region: Cupin_2; cl17218 693974010528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693974010529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693974010530 CAAX protease self-immunity; Region: Abi; pfam02517 693974010531 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 693974010532 pentamer interface [polypeptide binding]; other site 693974010533 dodecaamer interface [polypeptide binding]; other site 693974010534 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693974010535 Peptidase family U32; Region: Peptidase_U32; pfam01136 693974010536 Collagenase; Region: DUF3656; pfam12392 693974010537 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693974010538 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693974010539 active site 693974010540 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 693974010541 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693974010542 putative DNA binding site [nucleotide binding]; other site 693974010543 putative Zn2+ binding site [ion binding]; other site 693974010544 AsnC family; Region: AsnC_trans_reg; pfam01037 693974010545 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 693974010546 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 693974010547 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693974010548 active site 693974010549 catalytic residues [active] 693974010550 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 693974010551 PA/protease or protease-like domain interface [polypeptide binding]; other site 693974010552 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 693974010553 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 693974010554 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 693974010555 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693974010556 Transposase; Region: HTH_Tnp_1; pfam01527 693974010557 putative transposase OrfB; Reviewed; Region: PHA02517 693974010558 HTH-like domain; Region: HTH_21; pfam13276 693974010559 Integrase core domain; Region: rve; pfam00665 693974010560 Integrase core domain; Region: rve_3; pfam13683 693974010561 inner membrane transport permease; Provisional; Region: PRK15066 693974010562 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693974010563 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693974010564 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693974010565 Walker A/P-loop; other site 693974010566 ATP binding site [chemical binding]; other site 693974010567 Q-loop/lid; other site 693974010568 ABC transporter signature motif; other site 693974010569 Walker B; other site 693974010570 D-loop; other site 693974010571 H-loop/switch region; other site 693974010572 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693974010573 active site 693974010574 aromatic acid decarboxylase; Validated; Region: PRK05920 693974010575 Flavoprotein; Region: Flavoprotein; pfam02441 693974010576 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 693974010577 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693974010578 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693974010579 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693974010580 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 693974010581 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 693974010582 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 693974010583 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693974010584 hypothetical protein; Provisional; Region: PRK11627 693974010585 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 693974010586 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 693974010587 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 693974010588 substrate binding site [chemical binding]; other site 693974010589 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 693974010590 muropeptide transporter; Reviewed; Region: ampG; PRK11902 693974010591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974010592 putative substrate translocation pore; other site 693974010593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 693974010594 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 693974010595 Predicted integral membrane protein [Function unknown]; Region: COG5652 693974010596 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 693974010597 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 693974010598 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 693974010599 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 693974010600 Nitrogen regulatory protein P-II; Region: P-II; smart00938 693974010601 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 693974010602 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 693974010603 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974010604 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 693974010605 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693974010606 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 693974010607 Protein of unknown function (DUF819); Region: DUF819; cl02317 693974010608 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 693974010609 Tetratricopeptide repeat; Region: TPR_9; pfam13371 693974010610 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 693974010611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974010612 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693974010613 Coenzyme A binding pocket [chemical binding]; other site 693974010614 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693974010615 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 693974010616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974010617 peptide chain release factor 1; Validated; Region: prfA; PRK00591 693974010618 This domain is found in peptide chain release factors; Region: PCRF; smart00937 693974010619 RF-1 domain; Region: RF-1; pfam00472 693974010620 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 693974010621 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 693974010622 tRNA; other site 693974010623 putative tRNA binding site [nucleotide binding]; other site 693974010624 putative NADP binding site [chemical binding]; other site 693974010625 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 693974010626 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 693974010627 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 693974010628 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 693974010629 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693974010630 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 693974010631 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 693974010632 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693974010633 active site 693974010634 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974010635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974010636 dimerization interface [polypeptide binding]; other site 693974010637 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974010638 dimer interface [polypeptide binding]; other site 693974010639 putative CheW interface [polypeptide binding]; other site 693974010640 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 693974010641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693974010642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693974010643 DNA binding residues [nucleotide binding] 693974010644 Uncharacterized conserved protein [Function unknown]; Region: COG3595 693974010645 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 693974010646 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 693974010647 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693974010648 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 693974010649 RNA binding surface [nucleotide binding]; other site 693974010650 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 693974010651 active site 693974010652 uracil binding [chemical binding]; other site 693974010653 maltose O-acetyltransferase; Provisional; Region: PRK10092 693974010654 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 693974010655 trimer interface [polypeptide binding]; other site 693974010656 active site 693974010657 substrate binding site [chemical binding]; other site 693974010658 CoA binding site [chemical binding]; other site 693974010659 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 693974010660 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 693974010661 active site 693974010662 Zn binding site [ion binding]; other site 693974010663 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693974010664 synthetase active site [active] 693974010665 NTP binding site [chemical binding]; other site 693974010666 metal binding site [ion binding]; metal-binding site 693974010667 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 693974010668 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693974010669 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 693974010670 putative C-terminal domain interface [polypeptide binding]; other site 693974010671 putative GSH binding site (G-site) [chemical binding]; other site 693974010672 putative dimer interface [polypeptide binding]; other site 693974010673 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 693974010674 dimer interface [polypeptide binding]; other site 693974010675 N-terminal domain interface [polypeptide binding]; other site 693974010676 substrate binding pocket (H-site) [chemical binding]; other site 693974010677 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974010678 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974010679 N-terminal plug; other site 693974010680 ligand-binding site [chemical binding]; other site 693974010681 Bacterial PH domain; Region: DUF304; pfam03703 693974010682 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 693974010683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 693974010684 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 693974010685 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 693974010686 malate dehydrogenase; Provisional; Region: PRK13529 693974010687 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693974010688 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 693974010689 NAD(P) binding site [chemical binding]; other site 693974010690 Protein of unknown function (DUF3069); Region: DUF3069; pfam11269 693974010691 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 693974010692 active site 693974010693 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693974010694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693974010695 TPR motif; other site 693974010696 binding surface 693974010697 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693974010698 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974010699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974010700 metal binding site [ion binding]; metal-binding site 693974010701 active site 693974010702 I-site; other site 693974010703 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693974010704 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974010705 substrate binding pocket [chemical binding]; other site 693974010706 membrane-bound complex binding site; other site 693974010707 hinge residues; other site 693974010708 epoxyqueuosine reductase; Region: TIGR00276 693974010709 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 693974010710 Inclusion body protein; Region: PixA; pfam12306 693974010711 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 693974010712 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 693974010713 THF binding site; other site 693974010714 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 693974010715 substrate binding site [chemical binding]; other site 693974010716 THF binding site; other site 693974010717 zinc-binding site [ion binding]; other site 693974010718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974010719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974010720 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 693974010721 putative dimerization interface [polypeptide binding]; other site 693974010722 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 693974010723 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693974010724 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974010725 N-terminal plug; other site 693974010726 ligand-binding site [chemical binding]; other site 693974010727 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 693974010728 active site 693974010729 tetramer interface [polypeptide binding]; other site 693974010730 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693974010731 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 693974010732 substrate binding site [chemical binding]; other site 693974010733 dimer interface [polypeptide binding]; other site 693974010734 ATP binding site [chemical binding]; other site 693974010735 azurin; Region: azurin; TIGR02695 693974010736 Protein of unknown function (DUF3103); Region: DUF3103; pfam11301 693974010737 Protein of unknown function (DUF3622); Region: DUF3622; pfam12286 693974010738 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 693974010739 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 693974010740 putative active site [active] 693974010741 catalytic site [active] 693974010742 putative metal binding site [ion binding]; other site 693974010743 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693974010744 active site 693974010745 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 693974010746 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 693974010747 putative active site [active] 693974010748 putative metal binding site [ion binding]; other site 693974010749 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693974010750 FOG: CBS domain [General function prediction only]; Region: COG0517 693974010751 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693974010752 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 693974010753 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 693974010754 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693974010755 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 693974010756 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 693974010757 substrate binding pocket [chemical binding]; other site 693974010758 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 693974010759 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 693974010760 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974010761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974010762 metal binding site [ion binding]; metal-binding site 693974010763 active site 693974010764 I-site; other site 693974010765 YcaO domain protein; Region: TIGR03549 693974010766 OsmC-like protein; Region: OsmC; pfam02566 693974010767 YcaO-like family; Region: YcaO; pfam02624 693974010768 Cache domain; Region: Cache_2; pfam08269 693974010769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974010770 dimerization interface [polypeptide binding]; other site 693974010771 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974010772 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974010773 dimer interface [polypeptide binding]; other site 693974010774 putative CheW interface [polypeptide binding]; other site 693974010775 Ribosome recycling factor; Region: RRF_GI; pfam12614 693974010776 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 693974010777 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 693974010778 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974010779 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974010780 metal binding site [ion binding]; metal-binding site 693974010781 active site 693974010782 I-site; other site 693974010783 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 693974010784 Uncharacterized conserved protein [Function unknown]; Region: COG4925 693974010785 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 693974010786 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 693974010787 putative NAD(P) binding site [chemical binding]; other site 693974010788 putative substrate binding site [chemical binding]; other site 693974010789 catalytic Zn binding site [ion binding]; other site 693974010790 structural Zn binding site [ion binding]; other site 693974010791 dimer interface [polypeptide binding]; other site 693974010792 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693974010793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974010794 putative substrate translocation pore; other site 693974010795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974010796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974010797 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 693974010798 putative effector binding pocket; other site 693974010799 putative dimerization interface [polypeptide binding]; other site 693974010800 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 693974010801 active site 693974010802 dimer interface [polypeptide binding]; other site 693974010803 motif 1; other site 693974010804 motif 2; other site 693974010805 motif 3; other site 693974010806 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 693974010807 anticodon binding site; other site 693974010808 glycine dehydrogenase; Provisional; Region: PRK05367 693974010809 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693974010810 tetramer interface [polypeptide binding]; other site 693974010811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974010812 catalytic residue [active] 693974010813 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693974010814 tetramer interface [polypeptide binding]; other site 693974010815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974010816 catalytic residue [active] 693974010817 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 693974010818 lipoyl attachment site [posttranslational modification]; other site 693974010819 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 693974010820 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693974010821 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693974010822 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 693974010823 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 693974010824 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 693974010825 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 693974010826 Cell division protein ZapA; Region: ZapA; pfam05164 693974010827 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 693974010828 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 693974010829 dihydromonapterin reductase; Provisional; Region: PRK06483 693974010830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974010831 NAD(P) binding site [chemical binding]; other site 693974010832 active site 693974010833 Protein of unknown function, DUF393; Region: DUF393; pfam04134 693974010834 malate dehydrogenase; Provisional; Region: PRK05086 693974010835 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 693974010836 NAD binding site [chemical binding]; other site 693974010837 dimerization interface [polypeptide binding]; other site 693974010838 Substrate binding site [chemical binding]; other site 693974010839 arginine repressor; Provisional; Region: PRK05066 693974010840 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 693974010841 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 693974010842 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 693974010843 NADH(P)-binding; Region: NAD_binding_10; pfam13460 693974010844 NAD binding site [chemical binding]; other site 693974010845 substrate binding site [chemical binding]; other site 693974010846 putative active site [active] 693974010847 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974010848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974010849 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974010850 putative effector binding pocket; other site 693974010851 dimerization interface [polypeptide binding]; other site 693974010852 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 693974010853 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 693974010854 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 693974010855 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 693974010856 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693974010857 Walker A/P-loop; other site 693974010858 ATP binding site [chemical binding]; other site 693974010859 Q-loop/lid; other site 693974010860 ABC transporter signature motif; other site 693974010861 Walker B; other site 693974010862 D-loop; other site 693974010863 H-loop/switch region; other site 693974010864 TOBE domain; Region: TOBE_2; pfam08402 693974010865 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 693974010866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974010867 dimer interface [polypeptide binding]; other site 693974010868 conserved gate region; other site 693974010869 putative PBP binding loops; other site 693974010870 ABC-ATPase subunit interface; other site 693974010871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693974010872 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693974010873 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693974010874 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 693974010875 putative C-terminal domain interface [polypeptide binding]; other site 693974010876 putative GSH binding site (G-site) [chemical binding]; other site 693974010877 putative dimer interface [polypeptide binding]; other site 693974010878 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 693974010879 dimer interface [polypeptide binding]; other site 693974010880 N-terminal domain interface [polypeptide binding]; other site 693974010881 substrate binding pocket (H-site) [chemical binding]; other site 693974010882 ferredoxin-NADP reductase; Provisional; Region: PRK10926 693974010883 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 693974010884 FAD binding pocket [chemical binding]; other site 693974010885 FAD binding motif [chemical binding]; other site 693974010886 phosphate binding motif [ion binding]; other site 693974010887 beta-alpha-beta structure motif; other site 693974010888 NAD binding pocket [chemical binding]; other site 693974010889 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 693974010890 catalytic core [active] 693974010891 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 693974010892 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 693974010893 active site 693974010894 FMN binding site [chemical binding]; other site 693974010895 substrate binding site [chemical binding]; other site 693974010896 3Fe-4S cluster binding site [ion binding]; other site 693974010897 Src Homology 3 domain superfamily; Region: SH3; cl17036 693974010898 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693974010899 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 693974010900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974010901 Walker A/P-loop; other site 693974010902 ATP binding site [chemical binding]; other site 693974010903 Q-loop/lid; other site 693974010904 ABC transporter signature motif; other site 693974010905 Walker B; other site 693974010906 D-loop; other site 693974010907 H-loop/switch region; other site 693974010908 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 693974010909 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 693974010910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974010911 binding surface 693974010912 TPR motif; other site 693974010913 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693974010914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974010915 binding surface 693974010916 TPR motif; other site 693974010917 TPR repeat; Region: TPR_11; pfam13414 693974010918 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 693974010919 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 693974010920 Nitrogen regulatory protein P-II; Region: P-II; smart00938 693974010921 Isochorismatase family; Region: Isochorismatase; pfam00857 693974010922 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 693974010923 catalytic triad [active] 693974010924 dimer interface [polypeptide binding]; other site 693974010925 conserved cis-peptide bond; other site 693974010926 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 693974010927 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 693974010928 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 693974010929 HAMP domain; Region: HAMP; pfam00672 693974010930 Histidine kinase; Region: HisKA_3; pfam07730 693974010931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974010932 ATP binding site [chemical binding]; other site 693974010933 Mg2+ binding site [ion binding]; other site 693974010934 G-X-G motif; other site 693974010935 transcriptional regulator NarL; Provisional; Region: PRK10651 693974010936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974010937 active site 693974010938 phosphorylation site [posttranslational modification] 693974010939 intermolecular recognition site; other site 693974010940 dimerization interface [polypeptide binding]; other site 693974010941 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693974010942 DNA binding residues [nucleotide binding] 693974010943 dimerization interface [polypeptide binding]; other site 693974010944 Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062 693974010945 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 693974010946 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 693974010947 Cl binding site [ion binding]; other site 693974010948 oligomer interface [polypeptide binding]; other site 693974010949 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 693974010950 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 693974010951 active site 693974010952 Zn binding site [ion binding]; other site 693974010953 aspartate kinase III; Validated; Region: PRK09084 693974010954 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 693974010955 nucleotide binding site [chemical binding]; other site 693974010956 substrate binding site [chemical binding]; other site 693974010957 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 693974010958 dimer interface [polypeptide binding]; other site 693974010959 allosteric regulatory binding pocket; other site 693974010960 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 693974010961 dimer interface [polypeptide binding]; other site 693974010962 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 693974010963 two-component response regulator; Provisional; Region: PRK11173 693974010964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974010965 active site 693974010966 phosphorylation site [posttranslational modification] 693974010967 intermolecular recognition site; other site 693974010968 dimerization interface [polypeptide binding]; other site 693974010969 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974010970 DNA binding site [nucleotide binding] 693974010971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693974010972 Transposase; Region: HTH_Tnp_1; pfam01527 693974010973 putative transposase OrfB; Reviewed; Region: PHA02517 693974010974 HTH-like domain; Region: HTH_21; pfam13276 693974010975 Integrase core domain; Region: rve; pfam00665 693974010976 Integrase core domain; Region: rve_3; pfam13683 693974010977 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 693974010978 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693974010979 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693974010980 fructose-1,6-bisphosphatase family protein; Region: PLN02628 693974010981 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 693974010982 AMP binding site [chemical binding]; other site 693974010983 metal binding site [ion binding]; metal-binding site 693974010984 active site 693974010985 hypothetical protein; Provisional; Region: PRK05208 693974010986 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693974010987 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693974010988 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 693974010989 active site 693974010990 metal binding site [ion binding]; metal-binding site 693974010991 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 693974010992 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 693974010993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974010994 active site 693974010995 phosphorylation site [posttranslational modification] 693974010996 intermolecular recognition site; other site 693974010997 dimerization interface [polypeptide binding]; other site 693974010998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693974010999 DNA binding residues [nucleotide binding] 693974011000 dimerization interface [polypeptide binding]; other site 693974011001 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 693974011002 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 693974011003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974011004 dimer interface [polypeptide binding]; other site 693974011005 phosphorylation site [posttranslational modification] 693974011006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974011007 ATP binding site [chemical binding]; other site 693974011008 Mg2+ binding site [ion binding]; other site 693974011009 G-X-G motif; other site 693974011010 tetrathionate reductase subunit B; Provisional; Region: PRK14993 693974011011 4Fe-4S binding domain; Region: Fer4; pfam00037 693974011012 tetrathionate reductase subunit C; Provisional; Region: PRK14992 693974011013 tetrathionate reductase subunit A; Provisional; Region: PRK14991 693974011014 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 693974011015 putative [Fe4-S4] binding site [ion binding]; other site 693974011016 putative molybdopterin cofactor binding site [chemical binding]; other site 693974011017 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 693974011018 putative molybdopterin cofactor binding site; other site 693974011019 PAS domain; Region: PAS_9; pfam13426 693974011020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974011021 putative active site [active] 693974011022 heme pocket [chemical binding]; other site 693974011023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974011024 PAS domain; Region: PAS_9; pfam13426 693974011025 putative active site [active] 693974011026 heme pocket [chemical binding]; other site 693974011027 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974011028 dimer interface [polypeptide binding]; other site 693974011029 putative CheW interface [polypeptide binding]; other site 693974011030 Protein of unknown function (DUF3581); Region: DUF3581; pfam12119 693974011031 phage shock protein C; Region: phageshock_pspC; TIGR02978 693974011032 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 693974011033 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 693974011034 Transglycosylase; Region: Transgly; pfam00912 693974011035 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693974011036 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 693974011037 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693974011038 ATP binding site [chemical binding]; other site 693974011039 putative Mg++ binding site [ion binding]; other site 693974011040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974011041 nucleotide binding region [chemical binding]; other site 693974011042 ATP-binding site [chemical binding]; other site 693974011043 Helicase associated domain (HA2); Region: HA2; pfam04408 693974011044 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 693974011045 GAF domain; Region: GAF; cl17456 693974011046 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974011047 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974011048 metal binding site [ion binding]; metal-binding site 693974011049 active site 693974011050 I-site; other site 693974011051 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974011052 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 693974011053 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 693974011054 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693974011055 Sel1-like repeats; Region: SEL1; smart00671 693974011056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974011057 TPR motif; other site 693974011058 binding surface 693974011059 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 693974011060 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693974011061 ligand binding site [chemical binding]; other site 693974011062 flexible hinge region; other site 693974011063 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693974011064 putative switch regulator; other site 693974011065 non-specific DNA interactions [nucleotide binding]; other site 693974011066 DNA binding site [nucleotide binding] 693974011067 sequence specific DNA binding site [nucleotide binding]; other site 693974011068 putative cAMP binding site [chemical binding]; other site 693974011069 Predicted membrane protein [Function unknown]; Region: COG3212 693974011070 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693974011071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974011072 active site 693974011073 phosphorylation site [posttranslational modification] 693974011074 intermolecular recognition site; other site 693974011075 dimerization interface [polypeptide binding]; other site 693974011076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974011077 DNA binding site [nucleotide binding] 693974011078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693974011079 HAMP domain; Region: HAMP; pfam00672 693974011080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 693974011081 dimer interface [polypeptide binding]; other site 693974011082 phosphorylation site [posttranslational modification] 693974011083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974011084 ATP binding site [chemical binding]; other site 693974011085 Mg2+ binding site [ion binding]; other site 693974011086 G-X-G motif; other site 693974011087 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 693974011088 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 693974011089 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 693974011090 NAD(P) binding site [chemical binding]; other site 693974011091 catalytic residues [active] 693974011092 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 693974011093 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 693974011094 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 693974011095 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693974011096 inhibitor-cofactor binding pocket; inhibition site 693974011097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974011098 catalytic residue [active] 693974011099 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 693974011100 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 693974011101 HDOD domain; Region: HDOD; pfam08668 693974011102 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693974011103 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693974011104 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 693974011105 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 693974011106 glutamine binding [chemical binding]; other site 693974011107 catalytic triad [active] 693974011108 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 693974011109 stringent starvation protein A; Provisional; Region: sspA; PRK09481 693974011110 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 693974011111 C-terminal domain interface [polypeptide binding]; other site 693974011112 putative GSH binding site (G-site) [chemical binding]; other site 693974011113 dimer interface [polypeptide binding]; other site 693974011114 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 693974011115 dimer interface [polypeptide binding]; other site 693974011116 N-terminal domain interface [polypeptide binding]; other site 693974011117 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 693974011118 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 693974011119 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 693974011120 Qi binding site; other site 693974011121 intrachain domain interface; other site 693974011122 interchain domain interface [polypeptide binding]; other site 693974011123 heme bH binding site [chemical binding]; other site 693974011124 heme bL binding site [chemical binding]; other site 693974011125 Qo binding site; other site 693974011126 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 693974011127 interchain domain interface [polypeptide binding]; other site 693974011128 intrachain domain interface; other site 693974011129 Qi binding site; other site 693974011130 Qo binding site; other site 693974011131 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 693974011132 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 693974011133 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 693974011134 [2Fe-2S] cluster binding site [ion binding]; other site 693974011135 FtsH protease regulator HflC; Provisional; Region: PRK11029 693974011136 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 693974011137 FtsH protease regulator HflK; Provisional; Region: PRK10930 693974011138 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 693974011139 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 693974011140 GTPase HflX; Provisional; Region: PRK11058 693974011141 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 693974011142 HflX GTPase family; Region: HflX; cd01878 693974011143 G1 box; other site 693974011144 GTP/Mg2+ binding site [chemical binding]; other site 693974011145 Switch I region; other site 693974011146 G2 box; other site 693974011147 G3 box; other site 693974011148 Switch II region; other site 693974011149 G4 box; other site 693974011150 G5 box; other site 693974011151 bacterial Hfq-like; Region: Hfq; cd01716 693974011152 hexamer interface [polypeptide binding]; other site 693974011153 Sm1 motif; other site 693974011154 RNA binding site [nucleotide binding]; other site 693974011155 Sm2 motif; other site 693974011156 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 693974011157 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 693974011158 active site 693974011159 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 693974011160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974011161 ATP binding site [chemical binding]; other site 693974011162 Mg2+ binding site [ion binding]; other site 693974011163 G-X-G motif; other site 693974011164 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 693974011165 ATP binding site [chemical binding]; other site 693974011166 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 693974011167 AMIN domain; Region: AMIN; pfam11741 693974011168 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 693974011169 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693974011170 active site 693974011171 metal binding site [ion binding]; metal-binding site 693974011172 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 693974011173 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693974011174 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 693974011175 putative carbohydrate kinase; Provisional; Region: PRK10565 693974011176 Uncharacterized conserved protein [Function unknown]; Region: COG0062 693974011177 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 693974011178 putative substrate binding site [chemical binding]; other site 693974011179 putative ATP binding site [chemical binding]; other site 693974011180 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 693974011181 catalytic site [active] 693974011182 putative active site [active] 693974011183 putative substrate binding site [chemical binding]; other site 693974011184 dimer interface [polypeptide binding]; other site 693974011185 GTPase RsgA; Reviewed; Region: PRK12288 693974011186 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693974011187 RNA binding site [nucleotide binding]; other site 693974011188 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 693974011189 GTPase/Zn-binding domain interface [polypeptide binding]; other site 693974011190 GTP/Mg2+ binding site [chemical binding]; other site 693974011191 G4 box; other site 693974011192 G5 box; other site 693974011193 G1 box; other site 693974011194 Switch I region; other site 693974011195 G2 box; other site 693974011196 G3 box; other site 693974011197 Switch II region; other site 693974011198 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 693974011199 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693974011200 EamA-like transporter family; Region: EamA; pfam00892 693974011201 EamA-like transporter family; Region: EamA; pfam00892 693974011202 putative mechanosensitive channel protein; Provisional; Region: PRK10929 693974011203 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 693974011204 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693974011205 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 693974011206 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 693974011207 active site 693974011208 catalytic site [active] 693974011209 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 693974011210 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 693974011211 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693974011212 NAD binding site [chemical binding]; other site 693974011213 ligand binding site [chemical binding]; other site 693974011214 catalytic site [active] 693974011215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974011216 PAS fold; Region: PAS_3; pfam08447 693974011217 putative active site [active] 693974011218 heme pocket [chemical binding]; other site 693974011219 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974011220 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974011221 dimer interface [polypeptide binding]; other site 693974011222 putative CheW interface [polypeptide binding]; other site 693974011223 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 693974011224 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 693974011225 Protein kinase domain; Region: Pkinase; pfam00069 693974011226 Catalytic domain of Protein Kinases; Region: PKc; cd00180 693974011227 active site 693974011228 ATP binding site [chemical binding]; other site 693974011229 substrate binding site [chemical binding]; other site 693974011230 activation loop (A-loop); other site 693974011231 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 693974011232 active site 693974011233 Cache domain; Region: Cache_1; pfam02743 693974011234 PAS fold; Region: PAS_4; pfam08448 693974011235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974011236 putative active site [active] 693974011237 heme pocket [chemical binding]; other site 693974011238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974011239 PAS fold; Region: PAS_3; pfam08447 693974011240 putative active site [active] 693974011241 heme pocket [chemical binding]; other site 693974011242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974011243 dimer interface [polypeptide binding]; other site 693974011244 phosphorylation site [posttranslational modification] 693974011245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974011246 ATP binding site [chemical binding]; other site 693974011247 Mg2+ binding site [ion binding]; other site 693974011248 G-X-G motif; other site 693974011249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974011250 Response regulator receiver domain; Region: Response_reg; pfam00072 693974011251 active site 693974011252 phosphorylation site [posttranslational modification] 693974011253 intermolecular recognition site; other site 693974011254 dimerization interface [polypeptide binding]; other site 693974011255 Response regulator receiver domain; Region: Response_reg; pfam00072 693974011256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974011257 active site 693974011258 phosphorylation site [posttranslational modification] 693974011259 intermolecular recognition site; other site 693974011260 dimerization interface [polypeptide binding]; other site 693974011261 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 693974011262 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 693974011263 putative active site [active] 693974011264 PhoH-like protein; Region: PhoH; pfam02562 693974011265 ATP-dependent helicase HepA; Validated; Region: PRK04914 693974011266 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693974011267 ATP binding site [chemical binding]; other site 693974011268 putative Mg++ binding site [ion binding]; other site 693974011269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974011270 nucleotide binding region [chemical binding]; other site 693974011271 ATP-binding site [chemical binding]; other site 693974011272 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 693974011273 enoyl-CoA hydratase; Provisional; Region: PRK07509 693974011274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693974011275 substrate binding site [chemical binding]; other site 693974011276 oxyanion hole (OAH) forming residues; other site 693974011277 trimer interface [polypeptide binding]; other site 693974011278 Response regulator receiver domain; Region: Response_reg; pfam00072 693974011279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974011280 active site 693974011281 phosphorylation site [posttranslational modification] 693974011282 intermolecular recognition site; other site 693974011283 dimerization interface [polypeptide binding]; other site 693974011284 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 693974011285 PAS domain; Region: PAS_9; pfam13426 693974011286 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974011287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974011288 metal binding site [ion binding]; metal-binding site 693974011289 active site 693974011290 I-site; other site 693974011291 RNase E inhibitor protein; Provisional; Region: PRK11191 693974011292 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 693974011293 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 693974011294 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693974011295 putative acyl-acceptor binding pocket; other site 693974011296 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 693974011297 Periplasmic binding protein TroA_c. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145 693974011298 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 693974011299 putative ligand binding site [chemical binding]; other site 693974011300 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693974011301 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693974011302 formate--tetrahydrofolate ligase; Provisional; Region: PRK13506 693974011303 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 693974011304 Potassium binding sites [ion binding]; other site 693974011305 Cesium cation binding sites [ion binding]; other site 693974011306 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693974011307 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693974011308 active site 693974011309 catalytic tetrad [active] 693974011310 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 693974011311 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 693974011312 active site 2 [active] 693974011313 active site 1 [active] 693974011314 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 693974011315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974011316 S-adenosylmethionine binding site [chemical binding]; other site 693974011317 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 693974011318 TraB family; Region: TraB; pfam01963 693974011319 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974011320 FOG: CBS domain [General function prediction only]; Region: COG0517 693974011321 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 693974011322 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974011323 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974011324 metal binding site [ion binding]; metal-binding site 693974011325 active site 693974011326 I-site; other site 693974011327 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 693974011328 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 693974011329 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974011330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974011331 active site 693974011332 phosphorylation site [posttranslational modification] 693974011333 intermolecular recognition site; other site 693974011334 dimerization interface [polypeptide binding]; other site 693974011335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974011336 Response regulator receiver domain; Region: Response_reg; pfam00072 693974011337 active site 693974011338 phosphorylation site [posttranslational modification] 693974011339 intermolecular recognition site; other site 693974011340 dimerization interface [polypeptide binding]; other site 693974011341 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693974011342 IHF dimer interface [polypeptide binding]; other site 693974011343 IHF - DNA interface [nucleotide binding]; other site 693974011344 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 693974011345 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 693974011346 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693974011347 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974011348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974011349 active site 693974011350 phosphorylation site [posttranslational modification] 693974011351 intermolecular recognition site; other site 693974011352 dimerization interface [polypeptide binding]; other site 693974011353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974011354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974011355 metal binding site [ion binding]; metal-binding site 693974011356 active site 693974011357 I-site; other site 693974011358 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974011359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974011360 active site 693974011361 phosphorylation site [posttranslational modification] 693974011362 intermolecular recognition site; other site 693974011363 CHASE domain; Region: CHASE; pfam03924 693974011364 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693974011365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974011366 putative active site [active] 693974011367 heme pocket [chemical binding]; other site 693974011368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974011369 dimer interface [polypeptide binding]; other site 693974011370 phosphorylation site [posttranslational modification] 693974011371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974011372 ATP binding site [chemical binding]; other site 693974011373 Mg2+ binding site [ion binding]; other site 693974011374 G-X-G motif; other site 693974011375 conserved hypothetical protein; Region: QEGLA; TIGR02421 693974011376 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693974011377 amino acid carrier protein; Region: agcS; TIGR00835 693974011378 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 693974011379 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693974011380 Beta-Casp domain; Region: Beta-Casp; smart01027 693974011381 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 693974011382 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 693974011383 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693974011384 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 693974011385 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 693974011386 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693974011387 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693974011388 catalytic residues [active] 693974011389 Predicted permeases [General function prediction only]; Region: COG0701 693974011390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693974011391 dimerization interface [polypeptide binding]; other site 693974011392 putative DNA binding site [nucleotide binding]; other site 693974011393 putative Zn2+ binding site [ion binding]; other site 693974011394 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 693974011395 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 693974011396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974011397 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693974011398 dimerization interface [polypeptide binding]; other site 693974011399 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 693974011400 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 693974011401 conserved cys residue [active] 693974011402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974011403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693974011404 Isochorismatase family; Region: Isochorismatase; pfam00857 693974011405 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 693974011406 catalytic triad [active] 693974011407 conserved cis-peptide bond; other site 693974011408 Radical SAM superfamily; Region: Radical_SAM; pfam04055 693974011409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974011410 FeS/SAM binding site; other site 693974011411 Uncharacterized conserved protein [Function unknown]; Region: COG1359 693974011412 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693974011413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974011414 Coenzyme A binding pocket [chemical binding]; other site 693974011415 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693974011416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974011417 putative substrate translocation pore; other site 693974011418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974011419 putative substrate translocation pore; other site 693974011420 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693974011421 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974011422 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974011423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974011424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974011425 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974011426 putative effector binding pocket; other site 693974011427 dimerization interface [polypeptide binding]; other site 693974011428 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 693974011429 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 693974011430 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 693974011431 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 693974011432 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693974011433 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974011434 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974011435 Outer membrane efflux protein; Region: OEP; pfam02321 693974011436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693974011437 Protein of unknown function (DUF3012); Region: DUF3012; pfam11216 693974011438 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 693974011439 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 693974011440 hypothetical protein; Provisional; Region: PRK09256 693974011441 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 693974011442 Dehydroquinase class II; Region: DHquinase_II; pfam01220 693974011443 active site 693974011444 trimer interface [polypeptide binding]; other site 693974011445 dimer interface [polypeptide binding]; other site 693974011446 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 693974011447 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693974011448 carboxyltransferase (CT) interaction site; other site 693974011449 biotinylation site [posttranslational modification]; other site 693974011450 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 693974011451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974011452 NAD(P) binding site [chemical binding]; other site 693974011453 active site 693974011454 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 693974011455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974011456 putative substrate translocation pore; other site 693974011457 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 693974011458 FMN reductase; Validated; Region: fre; PRK08051 693974011459 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 693974011460 FAD binding pocket [chemical binding]; other site 693974011461 FAD binding motif [chemical binding]; other site 693974011462 phosphate binding motif [ion binding]; other site 693974011463 beta-alpha-beta structure motif; other site 693974011464 NAD binding pocket [chemical binding]; other site 693974011465 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 693974011466 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 693974011467 active site 693974011468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974011469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974011470 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693974011471 dimerization interface [polypeptide binding]; other site 693974011472 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693974011473 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693974011474 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 693974011475 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 693974011476 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 693974011477 active site 693974011478 Zn binding site [ion binding]; other site 693974011479 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 693974011480 Pathogenicity locus; Region: Cdd1; pfam11731 693974011481 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693974011482 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693974011483 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693974011484 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693974011485 catalytic residues [active] 693974011486 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693974011487 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693974011488 catalytic residues [active] 693974011489 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 693974011490 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 693974011491 FMN binding site [chemical binding]; other site 693974011492 substrate binding site [chemical binding]; other site 693974011493 putative catalytic residue [active] 693974011494 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 693974011495 putative dimer interface [polypeptide binding]; other site 693974011496 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693974011497 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 693974011498 UbiA prenyltransferase family; Region: UbiA; pfam01040 693974011499 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 693974011500 Part of AAA domain; Region: AAA_19; pfam13245 693974011501 Family description; Region: UvrD_C_2; pfam13538 693974011502 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693974011503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974011504 S-adenosylmethionine binding site [chemical binding]; other site 693974011505 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 693974011506 nudix motif; other site 693974011507 Predicted metalloprotease [General function prediction only]; Region: COG2321 693974011508 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 693974011509 Poxvirus P35 protein; Region: Pox_P35; pfam03213 693974011510 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 693974011511 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693974011512 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 693974011513 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 693974011514 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 693974011515 DctM-like transporters; Region: DctM; pfam06808 693974011516 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 693974011517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974011518 putative active site [active] 693974011519 PAS fold; Region: PAS_3; pfam08447 693974011520 heme pocket [chemical binding]; other site 693974011521 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974011522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974011523 metal binding site [ion binding]; metal-binding site 693974011524 active site 693974011525 I-site; other site 693974011526 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693974011527 thioredoxin 2; Provisional; Region: PRK10996 693974011528 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 693974011529 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693974011530 catalytic residues [active] 693974011531 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693974011532 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 693974011533 transmembrane helices; other site 693974011534 putative MFS family transporter protein; Provisional; Region: PRK03633 693974011535 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 693974011536 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693974011537 RNA binding surface [nucleotide binding]; other site 693974011538 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 693974011539 active site 693974011540 uracil binding [chemical binding]; other site 693974011541 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 693974011542 SPFH domain / Band 7 family; Region: Band_7; pfam01145 693974011543 Predicted permease; Region: DUF318; cl17795 693974011544 Predicted permease; Region: DUF318; cl17795 693974011545 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 693974011546 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 693974011547 DNA binding residues [nucleotide binding] 693974011548 dimer interface [polypeptide binding]; other site 693974011549 metal binding site [ion binding]; metal-binding site 693974011550 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 693974011551 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 693974011552 purine monophosphate binding site [chemical binding]; other site 693974011553 dimer interface [polypeptide binding]; other site 693974011554 putative catalytic residues [active] 693974011555 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 693974011556 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 693974011557 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 693974011558 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 693974011559 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 693974011560 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 693974011561 Peptidase M60-like family; Region: M60-like; pfam13402 693974011562 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 693974011563 short chain dehydrogenase; Provisional; Region: PRK06181 693974011564 NADP binding site [chemical binding]; other site 693974011565 homodimer interface [polypeptide binding]; other site 693974011566 substrate binding site [chemical binding]; other site 693974011567 active site 693974011568 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 693974011569 substrate binding site [chemical binding]; other site 693974011570 active site 693974011571 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 693974011572 preprotein translocase subunit SecA; Reviewed; Region: PRK13107 693974011573 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 693974011574 SEC-C motif; Region: SEC-C; pfam02810 693974011575 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693974011576 Peptidase family M23; Region: Peptidase_M23; pfam01551 693974011577 Protein of unknown function (DUF721); Region: DUF721; cl02324 693974011578 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 693974011579 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 693974011580 cell division protein FtsZ; Validated; Region: PRK09330 693974011581 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 693974011582 nucleotide binding site [chemical binding]; other site 693974011583 SulA interaction site; other site 693974011584 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 693974011585 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693974011586 nucleotide binding site [chemical binding]; other site 693974011587 Cell division protein FtsA; Region: FtsA; pfam14450 693974011588 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 693974011589 Cell division protein FtsQ; Region: FtsQ; pfam03799 693974011590 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 693974011591 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693974011592 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693974011593 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693974011594 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 693974011595 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 693974011596 active site 693974011597 homodimer interface [polypeptide binding]; other site 693974011598 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 693974011599 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 693974011600 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693974011601 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693974011602 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 693974011603 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 693974011604 Mg++ binding site [ion binding]; other site 693974011605 putative catalytic motif [active] 693974011606 putative substrate binding site [chemical binding]; other site 693974011607 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 693974011608 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693974011609 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693974011610 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693974011611 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 693974011612 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693974011613 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693974011614 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693974011615 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 693974011616 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 693974011617 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693974011618 Cell division protein FtsL; Region: FtsL; pfam04999 693974011619 MraW methylase family; Region: Methyltransf_5; pfam01795 693974011620 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 693974011621 cell division protein MraZ; Reviewed; Region: PRK00326 693974011622 MraZ protein; Region: MraZ; pfam02381 693974011623 MraZ protein; Region: MraZ; pfam02381 693974011624 glycerol kinase; Provisional; Region: glpK; PRK00047 693974011625 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 693974011626 N- and C-terminal domain interface [polypeptide binding]; other site 693974011627 active site 693974011628 MgATP binding site [chemical binding]; other site 693974011629 catalytic site [active] 693974011630 metal binding site [ion binding]; metal-binding site 693974011631 glycerol binding site [chemical binding]; other site 693974011632 homotetramer interface [polypeptide binding]; other site 693974011633 homodimer interface [polypeptide binding]; other site 693974011634 FBP binding site [chemical binding]; other site 693974011635 protein IIAGlc interface [polypeptide binding]; other site 693974011636 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 693974011637 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 693974011638 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 693974011639 substrate binding site [chemical binding]; other site 693974011640 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 693974011641 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 693974011642 substrate binding site [chemical binding]; other site 693974011643 ligand binding site [chemical binding]; other site 693974011644 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 693974011645 tartrate dehydrogenase; Region: TTC; TIGR02089 693974011646 2-isopropylmalate synthase; Validated; Region: PRK00915 693974011647 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 693974011648 active site 693974011649 catalytic residues [active] 693974011650 metal binding site [ion binding]; metal-binding site 693974011651 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 693974011652 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974011653 I-site; other site 693974011654 active site 693974011655 metal binding site [ion binding]; metal-binding site 693974011656 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 693974011657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693974011658 ATP binding site [chemical binding]; other site 693974011659 putative Mg++ binding site [ion binding]; other site 693974011660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974011661 nucleotide binding region [chemical binding]; other site 693974011662 ATP-binding site [chemical binding]; other site 693974011663 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 693974011664 HRDC domain; Region: HRDC; pfam00570 693974011665 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693974011666 CoenzymeA binding site [chemical binding]; other site 693974011667 subunit interaction site [polypeptide binding]; other site 693974011668 PHB binding site; other site 693974011669 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 693974011670 N-acetylglutamate synthase; Validated; Region: PRK05279 693974011671 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 693974011672 putative feedback inhibition sensing region; other site 693974011673 putative nucleotide binding site [chemical binding]; other site 693974011674 putative substrate binding site [chemical binding]; other site 693974011675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974011676 Coenzyme A binding pocket [chemical binding]; other site 693974011677 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 693974011678 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 693974011679 hypothetical protein; Reviewed; Region: PRK00024 693974011680 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 693974011681 MPN+ (JAMM) motif; other site 693974011682 Zinc-binding site [ion binding]; other site 693974011683 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 693974011684 Flavoprotein; Region: Flavoprotein; pfam02441 693974011685 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 693974011686 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693974011687 trimer interface [polypeptide binding]; other site 693974011688 active site 693974011689 division inhibitor protein; Provisional; Region: slmA; PRK09480 693974011690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974011691 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693974011692 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693974011693 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 693974011694 GTP cyclohydrolase I; Provisional; Region: PLN03044 693974011695 active site 693974011696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693974011697 active site 693974011698 ribonuclease PH; Reviewed; Region: rph; PRK00173 693974011699 Ribonuclease PH; Region: RNase_PH_bact; cd11362 693974011700 hexamer interface [polypeptide binding]; other site 693974011701 active site 693974011702 hypothetical protein; Provisional; Region: PRK11820 693974011703 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 693974011704 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 693974011705 HipA N-terminal domain; Region: Couple_hipA; pfam13657 693974011706 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 693974011707 HipA-like N-terminal domain; Region: HipA_N; pfam07805 693974011708 HipA-like C-terminal domain; Region: HipA_C; pfam07804 693974011709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974011710 non-specific DNA binding site [nucleotide binding]; other site 693974011711 salt bridge; other site 693974011712 sequence-specific DNA binding site [nucleotide binding]; other site 693974011713 ERCC4 domain; Region: ERCC4; smart00891 693974011714 dUMP phosphatase; Provisional; Region: PRK09449 693974011715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693974011716 motif II; other site 693974011717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974011718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974011719 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974011720 putative effector binding pocket; other site 693974011721 dimerization interface [polypeptide binding]; other site 693974011722 Protein of unknown function DUF262; Region: DUF262; pfam03235 693974011723 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 693974011724 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 693974011725 cofactor binding site; other site 693974011726 DNA binding site [nucleotide binding] 693974011727 substrate interaction site [chemical binding]; other site 693974011728 Fic family protein [Function unknown]; Region: COG3177 693974011729 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 693974011730 Fic/DOC family; Region: Fic; pfam02661 693974011731 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 693974011732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974011733 putative substrate translocation pore; other site 693974011734 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693974011735 Phosphotransferase enzyme family; Region: APH; pfam01636 693974011736 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 693974011737 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693974011738 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 693974011739 active site 693974011740 ribonuclease E; Reviewed; Region: rne; PRK10811 693974011741 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 693974011742 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 693974011743 catalytic site [active] 693974011744 G-X2-G-X-G-K; other site 693974011745 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 693974011746 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 693974011747 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693974011748 Zn2+ binding site [ion binding]; other site 693974011749 Mg2+ binding site [ion binding]; other site 693974011750 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693974011751 synthetase active site [active] 693974011752 NTP binding site [chemical binding]; other site 693974011753 metal binding site [ion binding]; metal-binding site 693974011754 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 693974011755 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 693974011756 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693974011757 homotrimer interaction site [polypeptide binding]; other site 693974011758 putative active site [active] 693974011759 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 693974011760 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 693974011761 acyl-activating enzyme (AAE) consensus motif; other site 693974011762 putative AMP binding site [chemical binding]; other site 693974011763 putative active site [active] 693974011764 putative CoA binding site [chemical binding]; other site 693974011765 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 693974011766 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693974011767 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693974011768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 693974011769 Histidine kinase; Region: HisKA_3; pfam07730 693974011770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974011771 ATP binding site [chemical binding]; other site 693974011772 Mg2+ binding site [ion binding]; other site 693974011773 G-X-G motif; other site 693974011774 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693974011775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974011776 active site 693974011777 phosphorylation site [posttranslational modification] 693974011778 intermolecular recognition site; other site 693974011779 dimerization interface [polypeptide binding]; other site 693974011780 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693974011781 DNA binding residues [nucleotide binding] 693974011782 dimerization interface [polypeptide binding]; other site 693974011783 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 693974011784 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 693974011785 generic binding surface II; other site 693974011786 ssDNA binding site; other site 693974011787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693974011788 ATP binding site [chemical binding]; other site 693974011789 putative Mg++ binding site [ion binding]; other site 693974011790 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693974011791 nucleotide binding region [chemical binding]; other site 693974011792 ATP-binding site [chemical binding]; other site 693974011793 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 693974011794 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 693974011795 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693974011796 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693974011797 putative acyl-acceptor binding pocket; other site 693974011798 Phosphopantetheine attachment site; Region: PP-binding; cl09936 693974011799 acyl carrier protein; Provisional; Region: PRK05350 693974011800 Predicted membrane protein [Function unknown]; Region: COG4648 693974011801 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 693974011802 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693974011803 acyl-activating enzyme (AAE) consensus motif; other site 693974011804 AMP binding site [chemical binding]; other site 693974011805 active site 693974011806 CoA binding site [chemical binding]; other site 693974011807 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 693974011808 active site 2 [active] 693974011809 dimer interface [polypeptide binding]; other site 693974011810 active site 1 [active] 693974011811 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693974011812 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 693974011813 Ligand binding site; other site 693974011814 Putative Catalytic site; other site 693974011815 DXD motif; other site 693974011816 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 693974011817 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 693974011818 putative acyl-acceptor binding pocket; other site 693974011819 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 693974011820 active sites [active] 693974011821 tetramer interface [polypeptide binding]; other site 693974011822 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693974011823 active site 693974011824 Predicted exporter [General function prediction only]; Region: COG4258 693974011825 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 693974011826 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 693974011827 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 693974011828 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693974011829 dimer interface [polypeptide binding]; other site 693974011830 active site 693974011831 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 693974011832 putative active site 1 [active] 693974011833 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 693974011834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974011835 NAD(P) binding site [chemical binding]; other site 693974011836 active site 693974011837 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 693974011838 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693974011839 dimer interface [polypeptide binding]; other site 693974011840 active site 693974011841 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 693974011842 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 693974011843 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 693974011844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974011845 Coenzyme A binding pocket [chemical binding]; other site 693974011846 Benzoate membrane transport protein; Region: BenE; pfam03594 693974011847 benzoate transporter; Region: benE; TIGR00843 693974011848 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693974011849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974011850 non-specific DNA binding site [nucleotide binding]; other site 693974011851 salt bridge; other site 693974011852 sequence-specific DNA binding site [nucleotide binding]; other site 693974011853 Cupin domain; Region: Cupin_2; pfam07883 693974011854 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693974011855 active site residue [active] 693974011856 azoreductase; Reviewed; Region: PRK00170 693974011857 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693974011858 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693974011859 CoenzymeA binding site [chemical binding]; other site 693974011860 subunit interaction site [polypeptide binding]; other site 693974011861 PHB binding site; other site 693974011862 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 693974011863 putative active site [active] 693974011864 dimerization interface [polypeptide binding]; other site 693974011865 putative tRNAtyr binding site [nucleotide binding]; other site 693974011866 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693974011867 hypothetical protein; Reviewed; Region: PRK01637 693974011868 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 693974011869 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 693974011870 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693974011871 homodimer interface [polypeptide binding]; other site 693974011872 substrate-cofactor binding pocket; other site 693974011873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974011874 catalytic residue [active] 693974011875 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 693974011876 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 693974011877 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 693974011878 4Fe-4S binding domain; Region: Fer4_5; pfam12801 693974011879 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693974011880 Sulfatase; Region: Sulfatase; cl17466 693974011881 SnoaL-like domain; Region: SnoaL_3; pfam13474 693974011882 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974011883 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974011884 metal binding site [ion binding]; metal-binding site 693974011885 active site 693974011886 I-site; other site 693974011887 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 693974011888 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 693974011889 G1 box; other site 693974011890 putative GEF interaction site [polypeptide binding]; other site 693974011891 GTP/Mg2+ binding site [chemical binding]; other site 693974011892 Switch I region; other site 693974011893 G2 box; other site 693974011894 G3 box; other site 693974011895 Switch II region; other site 693974011896 G4 box; other site 693974011897 G5 box; other site 693974011898 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 693974011899 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 693974011900 glutamine synthetase; Provisional; Region: glnA; PRK09469 693974011901 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 693974011902 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693974011903 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693974011904 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693974011905 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 693974011906 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693974011907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693974011908 catalytic residue [active] 693974011909 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 693974011910 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 693974011911 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 693974011912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693974011913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974011914 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 693974011915 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 693974011916 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 693974011917 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693974011918 Peptidase family M23; Region: Peptidase_M23; pfam01551 693974011919 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 693974011920 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 693974011921 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974011922 N-terminal plug; other site 693974011923 ligand-binding site [chemical binding]; other site 693974011924 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 693974011925 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974011926 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974011927 metal binding site [ion binding]; metal-binding site 693974011928 active site 693974011929 I-site; other site 693974011930 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693974011931 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693974011932 active site 693974011933 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693974011934 HAMP domain; Region: HAMP; pfam00672 693974011935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974011936 dimer interface [polypeptide binding]; other site 693974011937 phosphorylation site [posttranslational modification] 693974011938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974011939 ATP binding site [chemical binding]; other site 693974011940 Mg2+ binding site [ion binding]; other site 693974011941 G-X-G motif; other site 693974011942 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693974011943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974011944 active site 693974011945 phosphorylation site [posttranslational modification] 693974011946 intermolecular recognition site; other site 693974011947 dimerization interface [polypeptide binding]; other site 693974011948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974011949 DNA binding site [nucleotide binding] 693974011950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974011951 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693974011952 Walker A/P-loop; other site 693974011953 ATP binding site [chemical binding]; other site 693974011954 Q-loop/lid; other site 693974011955 ABC transporter signature motif; other site 693974011956 Walker B; other site 693974011957 D-loop; other site 693974011958 H-loop/switch region; other site 693974011959 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693974011960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974011961 dimer interface [polypeptide binding]; other site 693974011962 conserved gate region; other site 693974011963 putative PBP binding loops; other site 693974011964 ABC-ATPase subunit interface; other site 693974011965 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693974011966 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693974011967 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 693974011968 MoaE homodimer interface [polypeptide binding]; other site 693974011969 MoaD interaction [polypeptide binding]; other site 693974011970 active site residues [active] 693974011971 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 693974011972 MoaE interaction surface [polypeptide binding]; other site 693974011973 MoeB interaction surface [polypeptide binding]; other site 693974011974 thiocarboxylated glycine; other site 693974011975 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 693974011976 trimer interface [polypeptide binding]; other site 693974011977 dimer interface [polypeptide binding]; other site 693974011978 putative active site [active] 693974011979 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 693974011980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974011981 FeS/SAM binding site; other site 693974011982 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 693974011983 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 693974011984 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693974011985 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 693974011986 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 693974011987 Cache domain; Region: Cache_1; pfam02743 693974011988 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974011989 dimerization interface [polypeptide binding]; other site 693974011990 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974011991 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974011992 dimer interface [polypeptide binding]; other site 693974011993 putative CheW interface [polypeptide binding]; other site 693974011994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 693974011995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 693974011996 MOSC domain; Region: MOSC; pfam03473 693974011997 3-alpha domain; Region: 3-alpha; pfam03475 693974011998 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974011999 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974012000 metal binding site [ion binding]; metal-binding site 693974012001 active site 693974012002 I-site; other site 693974012003 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 693974012004 substrate binding site [chemical binding]; other site 693974012005 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693974012006 ATP binding site [chemical binding]; other site 693974012007 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 693974012008 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 693974012009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974012010 S-adenosylmethionine binding site [chemical binding]; other site 693974012011 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974012012 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974012013 dimer interface [polypeptide binding]; other site 693974012014 putative CheW interface [polypeptide binding]; other site 693974012015 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 693974012016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693974012017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974012018 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 693974012019 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 693974012020 dimer interface [polypeptide binding]; other site 693974012021 active site 693974012022 metal binding site [ion binding]; metal-binding site 693974012023 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 693974012024 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 693974012025 potential catalytic triad [active] 693974012026 conserved cys residue [active] 693974012027 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693974012028 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 693974012029 putative C-terminal domain interface [polypeptide binding]; other site 693974012030 putative GSH binding site (G-site) [chemical binding]; other site 693974012031 putative dimer interface [polypeptide binding]; other site 693974012032 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 693974012033 N-terminal domain interface [polypeptide binding]; other site 693974012034 dimer interface [polypeptide binding]; other site 693974012035 substrate binding pocket (H-site) [chemical binding]; other site 693974012036 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 693974012037 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 693974012038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974012039 dimer interface [polypeptide binding]; other site 693974012040 phosphorylation site [posttranslational modification] 693974012041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974012042 ATP binding site [chemical binding]; other site 693974012043 Mg2+ binding site [ion binding]; other site 693974012044 G-X-G motif; other site 693974012045 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 693974012046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974012047 active site 693974012048 phosphorylation site [posttranslational modification] 693974012049 intermolecular recognition site; other site 693974012050 dimerization interface [polypeptide binding]; other site 693974012051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974012052 Walker A motif; other site 693974012053 ATP binding site [chemical binding]; other site 693974012054 Walker B motif; other site 693974012055 arginine finger; other site 693974012056 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693974012057 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 693974012058 Cation efflux family; Region: Cation_efflux; cl00316 693974012059 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 693974012060 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 693974012061 dimer interface [polypeptide binding]; other site 693974012062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974012063 active site 693974012064 phosphorylation site [posttranslational modification] 693974012065 intermolecular recognition site; other site 693974012066 dimerization interface [polypeptide binding]; other site 693974012067 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974012068 DNA binding site [nucleotide binding] 693974012069 two-component sensor protein; Provisional; Region: cpxA; PRK09470 693974012070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974012071 dimerization interface [polypeptide binding]; other site 693974012072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974012073 dimer interface [polypeptide binding]; other site 693974012074 phosphorylation site [posttranslational modification] 693974012075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974012076 ATP binding site [chemical binding]; other site 693974012077 Mg2+ binding site [ion binding]; other site 693974012078 G-X-G motif; other site 693974012079 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 693974012080 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 693974012081 NADP binding site [chemical binding]; other site 693974012082 dimer interface [polypeptide binding]; other site 693974012083 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 693974012084 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693974012085 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 693974012086 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 693974012087 tetramer interface [polypeptide binding]; other site 693974012088 heme binding pocket [chemical binding]; other site 693974012089 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 693974012090 GAF domain; Region: GAF; pfam01590 693974012091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974012092 Walker A motif; other site 693974012093 ATP binding site [chemical binding]; other site 693974012094 Walker B motif; other site 693974012095 arginine finger; other site 693974012096 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693974012097 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693974012098 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693974012099 NAD(P) binding site [chemical binding]; other site 693974012100 catalytic residues [active] 693974012101 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693974012102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974012103 NAD(P) binding site [chemical binding]; other site 693974012104 active site 693974012105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974012106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974012107 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 693974012108 putative effector binding pocket; other site 693974012109 putative dimerization interface [polypeptide binding]; other site 693974012110 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 693974012111 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 693974012112 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 693974012113 Dihaem cytochrome c; Region: DHC; pfam09626 693974012114 Predicted membrane protein [Function unknown]; Region: COG3212 693974012115 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 693974012116 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693974012117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974012118 active site 693974012119 phosphorylation site [posttranslational modification] 693974012120 intermolecular recognition site; other site 693974012121 dimerization interface [polypeptide binding]; other site 693974012122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974012123 DNA binding site [nucleotide binding] 693974012124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693974012125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 693974012126 dimer interface [polypeptide binding]; other site 693974012127 phosphorylation site [posttranslational modification] 693974012128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974012129 ATP binding site [chemical binding]; other site 693974012130 Mg2+ binding site [ion binding]; other site 693974012131 G-X-G motif; other site 693974012132 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693974012133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974012134 Coenzyme A binding pocket [chemical binding]; other site 693974012135 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 693974012136 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693974012137 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693974012138 catalytic residues [active] 693974012139 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 693974012140 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 693974012141 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 693974012142 catalytic residues [active] 693974012143 central insert; other site 693974012144 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 693974012145 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 693974012146 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 693974012147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693974012148 TPR motif; other site 693974012149 binding surface 693974012150 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 693974012151 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 693974012152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974012153 Walker A/P-loop; other site 693974012154 ATP binding site [chemical binding]; other site 693974012155 Q-loop/lid; other site 693974012156 ABC transporter signature motif; other site 693974012157 Walker B; other site 693974012158 D-loop; other site 693974012159 H-loop/switch region; other site 693974012160 CcmB protein; Region: CcmB; pfam03379 693974012161 heme exporter protein CcmC; Region: ccmC; TIGR01191 693974012162 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 693974012163 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 693974012164 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 693974012165 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693974012166 Sel1-like repeats; Region: SEL1; smart00671 693974012167 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 693974012168 Sodium Bile acid symporter family; Region: SBF; pfam01758 693974012169 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 693974012170 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974012171 FeS/SAM binding site; other site 693974012172 Uncharacterized conserved protein [Function unknown]; Region: COG3743 693974012173 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 693974012174 enterobactin receptor protein; Provisional; Region: PRK13483 693974012175 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974012176 N-terminal plug; other site 693974012177 ligand-binding site [chemical binding]; other site 693974012178 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974012179 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974012180 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 693974012181 putative effector binding pocket; other site 693974012182 dimerization interface [polypeptide binding]; other site 693974012183 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 693974012184 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 693974012185 active site 693974012186 nucleophile elbow; other site 693974012187 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 693974012188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974012189 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 693974012190 substrate binding pocket [chemical binding]; other site 693974012191 dimerization interface [polypeptide binding]; other site 693974012192 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693974012193 EamA-like transporter family; Region: EamA; pfam00892 693974012194 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 693974012195 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 693974012196 substrate binding pocket [chemical binding]; other site 693974012197 membrane-bound complex binding site; other site 693974012198 hinge residues; other site 693974012199 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 693974012200 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693974012201 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 693974012202 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693974012203 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693974012204 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693974012205 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693974012206 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693974012207 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693974012208 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693974012209 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693974012210 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 693974012211 metal binding site [ion binding]; metal-binding site 693974012212 putative dimer interface [polypeptide binding]; other site 693974012213 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693974012214 dimerization interface [polypeptide binding]; other site 693974012215 putative DNA binding site [nucleotide binding]; other site 693974012216 putative Zn2+ binding site [ion binding]; other site 693974012217 NIPSNAP; Region: NIPSNAP; pfam07978 693974012218 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 693974012219 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693974012220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974012221 S-adenosylmethionine binding site [chemical binding]; other site 693974012222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974012223 PAS domain; Region: PAS_9; pfam13426 693974012224 putative active site [active] 693974012225 heme pocket [chemical binding]; other site 693974012226 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974012227 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974012228 metal binding site [ion binding]; metal-binding site 693974012229 active site 693974012230 I-site; other site 693974012231 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974012232 DTW domain; Region: DTW; cl01221 693974012233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693974012234 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 693974012235 putative substrate translocation pore; other site 693974012236 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 693974012237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974012238 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 693974012239 substrate binding pocket [chemical binding]; other site 693974012240 dimerization interface [polypeptide binding]; other site 693974012241 Cache domain; Region: Cache_1; pfam02743 693974012242 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974012243 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974012244 dimerization interface [polypeptide binding]; other site 693974012245 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974012246 dimer interface [polypeptide binding]; other site 693974012247 putative CheW interface [polypeptide binding]; other site 693974012248 Cache domain; Region: Cache_1; pfam02743 693974012249 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974012250 dimerization interface [polypeptide binding]; other site 693974012251 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974012252 dimer interface [polypeptide binding]; other site 693974012253 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 693974012254 putative CheW interface [polypeptide binding]; other site 693974012255 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 693974012256 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693974012257 Sel1-like repeats; Region: SEL1; smart00671 693974012258 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 693974012259 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 693974012260 putative metal binding site [ion binding]; other site 693974012261 HDOD domain; Region: HDOD; pfam08668 693974012262 Spore germination protein; Region: Spore_permease; cl17796 693974012263 putative transporter; Provisional; Region: PRK11021 693974012264 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 693974012265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693974012266 dimerization interface [polypeptide binding]; other site 693974012267 putative Zn2+ binding site [ion binding]; other site 693974012268 putative DNA binding site [nucleotide binding]; other site 693974012269 AsnC family; Region: AsnC_trans_reg; pfam01037 693974012270 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 693974012271 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 693974012272 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 693974012273 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 693974012274 radical SAM peptide maturase, FibroRumin system; Region: rSAM_FibroRumin; TIGR04136 693974012275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974012276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974012277 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693974012278 dimerization interface [polypeptide binding]; other site 693974012279 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 693974012280 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 693974012281 dimer interface [polypeptide binding]; other site 693974012282 tetramer interface [polypeptide binding]; other site 693974012283 PYR/PP interface [polypeptide binding]; other site 693974012284 TPP binding site [chemical binding]; other site 693974012285 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693974012286 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 693974012287 TPP-binding site; other site 693974012288 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 693974012289 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 693974012290 nucleophilic elbow; other site 693974012291 catalytic triad; other site 693974012292 O-succinylbenzoate synthase; Provisional; Region: PRK05105 693974012293 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 693974012294 active site 693974012295 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 693974012296 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 693974012297 acyl-activating enzyme (AAE) consensus motif; other site 693974012298 putative AMP binding site [chemical binding]; other site 693974012299 putative active site [active] 693974012300 putative CoA binding site [chemical binding]; other site 693974012301 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 693974012302 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693974012303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693974012304 DNA binding residues [nucleotide binding] 693974012305 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 693974012306 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 693974012307 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 693974012308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974012309 Walker A/P-loop; other site 693974012310 ATP binding site [chemical binding]; other site 693974012311 Q-loop/lid; other site 693974012312 ABC transporter signature motif; other site 693974012313 Walker B; other site 693974012314 D-loop; other site 693974012315 H-loop/switch region; other site 693974012316 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 693974012317 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 693974012318 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 693974012319 P loop; other site 693974012320 GTP binding site [chemical binding]; other site 693974012321 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 693974012322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974012323 S-adenosylmethionine binding site [chemical binding]; other site 693974012324 Protein of unknown function (DUF1145); Region: DUF1145; cl11481 693974012325 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 693974012326 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 693974012327 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 693974012328 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693974012329 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974012330 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 693974012331 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 693974012332 B1 nucleotide binding pocket [chemical binding]; other site 693974012333 B2 nucleotide binding pocket [chemical binding]; other site 693974012334 CAS motifs; other site 693974012335 active site 693974012336 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974012337 dimerization interface [polypeptide binding]; other site 693974012338 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693974012339 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974012340 dimer interface [polypeptide binding]; other site 693974012341 putative CheW interface [polypeptide binding]; other site 693974012342 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693974012343 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 693974012344 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 693974012345 aromatic amino acid transport protein; Region: araaP; TIGR00837 693974012346 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 693974012347 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 693974012348 putative acyl-acceptor binding pocket; other site 693974012349 LexA repressor; Validated; Region: PRK00215 693974012350 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 693974012351 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693974012352 Catalytic site [active] 693974012353 Cell division inhibitor SulA; Region: SulA; cl01880 693974012354 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 693974012355 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00038 693974012356 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 693974012357 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693974012358 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693974012359 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693974012360 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693974012361 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 693974012362 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 693974012363 Subunit I/III interface [polypeptide binding]; other site 693974012364 D-pathway; other site 693974012365 Subunit I/VIIc interface [polypeptide binding]; other site 693974012366 Subunit I/IV interface [polypeptide binding]; other site 693974012367 Subunit I/II interface [polypeptide binding]; other site 693974012368 Low-spin heme (heme a) binding site [chemical binding]; other site 693974012369 Subunit I/VIIa interface [polypeptide binding]; other site 693974012370 Subunit I/VIa interface [polypeptide binding]; other site 693974012371 Dimer interface; other site 693974012372 Putative water exit pathway; other site 693974012373 Binuclear center (heme a3/CuB) [ion binding]; other site 693974012374 K-pathway; other site 693974012375 Subunit I/Vb interface [polypeptide binding]; other site 693974012376 Putative proton exit pathway; other site 693974012377 Subunit I/VIb interface; other site 693974012378 Subunit I/VIc interface [polypeptide binding]; other site 693974012379 Electron transfer pathway; other site 693974012380 Subunit I/VIIIb interface [polypeptide binding]; other site 693974012381 Subunit I/VIIb interface [polypeptide binding]; other site 693974012382 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 693974012383 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 693974012384 Subunit III/VIIa interface [polypeptide binding]; other site 693974012385 Phospholipid binding site [chemical binding]; other site 693974012386 Subunit I/III interface [polypeptide binding]; other site 693974012387 Subunit III/VIb interface [polypeptide binding]; other site 693974012388 Subunit III/VIa interface; other site 693974012389 Subunit III/Vb interface [polypeptide binding]; other site 693974012390 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 693974012391 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 693974012392 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 693974012393 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 693974012394 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 693974012395 UbiA prenyltransferase family; Region: UbiA; pfam01040 693974012396 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 693974012397 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 693974012398 Cu(I) binding site [ion binding]; other site 693974012399 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 693974012400 putative active site [active] 693974012401 putative metal binding site [ion binding]; other site 693974012402 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 693974012403 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 693974012404 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 693974012405 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693974012406 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 693974012407 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 693974012408 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 693974012409 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 693974012410 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 693974012411 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 693974012412 Sulfatase; Region: Sulfatase; pfam00884 693974012413 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 693974012414 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 693974012415 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 693974012416 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 693974012417 RNA binding site [nucleotide binding]; other site 693974012418 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 693974012419 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693974012420 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693974012421 Rho-activating domain of cytotoxic necrotizing factor; Region: CNF1; pfam05785 693974012422 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 693974012423 active site 693974012424 catalytic triad [active] 693974012425 oxyanion hole [active] 693974012426 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 693974012427 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693974012428 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 693974012429 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 693974012430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974012431 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693974012432 dimerization interface [polypeptide binding]; other site 693974012433 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693974012434 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974012435 DNA binding site [nucleotide binding] 693974012436 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 693974012437 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 693974012438 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 693974012439 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693974012440 ligand binding site [chemical binding]; other site 693974012441 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 693974012442 FHIPEP family; Region: FHIPEP; pfam00771 693974012443 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 693974012444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693974012445 binding surface 693974012446 TPR motif; other site 693974012447 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693974012448 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 693974012449 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 693974012450 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693974012451 Walker A motif; other site 693974012452 ATP binding site [chemical binding]; other site 693974012453 Walker B motif; other site 693974012454 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 693974012455 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693974012456 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693974012457 type III secretion system protein YscR; Provisional; Region: PRK12797 693974012458 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 693974012459 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693974012460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974012461 DNA binding site [nucleotide binding] 693974012462 Protein kinase domain; Region: Pkinase; pfam00069 693974012463 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 693974012464 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693974012465 Response regulator receiver domain; Region: Response_reg; pfam00072 693974012466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974012467 active site 693974012468 phosphorylation site [posttranslational modification] 693974012469 intermolecular recognition site; other site 693974012470 dimerization interface [polypeptide binding]; other site 693974012471 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974012472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974012473 metal binding site [ion binding]; metal-binding site 693974012474 active site 693974012475 I-site; other site 693974012476 CHASE domain; Region: CHASE; pfam03924 693974012477 PAS domain S-box; Region: sensory_box; TIGR00229 693974012478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974012479 putative active site [active] 693974012480 heme pocket [chemical binding]; other site 693974012481 PAS domain; Region: PAS_9; pfam13426 693974012482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974012483 putative active site [active] 693974012484 heme pocket [chemical binding]; other site 693974012485 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693974012486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974012487 putative active site [active] 693974012488 heme pocket [chemical binding]; other site 693974012489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974012490 putative active site [active] 693974012491 heme pocket [chemical binding]; other site 693974012492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693974012493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974012494 dimer interface [polypeptide binding]; other site 693974012495 phosphorylation site [posttranslational modification] 693974012496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974012497 ATP binding site [chemical binding]; other site 693974012498 Mg2+ binding site [ion binding]; other site 693974012499 G-X-G motif; other site 693974012500 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974012501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974012502 active site 693974012503 phosphorylation site [posttranslational modification] 693974012504 intermolecular recognition site; other site 693974012505 dimerization interface [polypeptide binding]; other site 693974012506 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693974012507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974012508 active site 693974012509 phosphorylation site [posttranslational modification] 693974012510 intermolecular recognition site; other site 693974012511 dimerization interface [polypeptide binding]; other site 693974012512 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 693974012513 osmolarity response regulator; Provisional; Region: ompR; PRK09468 693974012514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974012515 active site 693974012516 phosphorylation site [posttranslational modification] 693974012517 intermolecular recognition site; other site 693974012518 dimerization interface [polypeptide binding]; other site 693974012519 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974012520 DNA binding site [nucleotide binding] 693974012521 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 693974012522 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974012523 dimerization interface [polypeptide binding]; other site 693974012524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974012525 dimer interface [polypeptide binding]; other site 693974012526 phosphorylation site [posttranslational modification] 693974012527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974012528 ATP binding site [chemical binding]; other site 693974012529 Mg2+ binding site [ion binding]; other site 693974012530 G-X-G motif; other site 693974012531 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693974012532 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693974012533 dimerization interface [polypeptide binding]; other site 693974012534 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693974012535 dimer interface [polypeptide binding]; other site 693974012536 putative CheW interface [polypeptide binding]; other site 693974012537 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 693974012538 catalytic triad [active] 693974012539 dimer interface [polypeptide binding]; other site 693974012540 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 693974012541 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693974012542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974012543 active site 693974012544 phosphorylation site [posttranslational modification] 693974012545 intermolecular recognition site; other site 693974012546 dimerization interface [polypeptide binding]; other site 693974012547 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693974012548 DNA binding site [nucleotide binding] 693974012549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 693974012550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 693974012551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974012552 ATP binding site [chemical binding]; other site 693974012553 Mg2+ binding site [ion binding]; other site 693974012554 G-X-G motif; other site 693974012555 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 693974012556 MASE1; Region: MASE1; cl17823 693974012557 CHASE domain; Region: CHASE; pfam03924 693974012558 PAS domain S-box; Region: sensory_box; TIGR00229 693974012559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974012560 putative active site [active] 693974012561 heme pocket [chemical binding]; other site 693974012562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974012563 PAS domain; Region: PAS_9; pfam13426 693974012564 putative active site [active] 693974012565 heme pocket [chemical binding]; other site 693974012566 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693974012567 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974012568 metal binding site [ion binding]; metal-binding site 693974012569 active site 693974012570 I-site; other site 693974012571 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974012572 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 693974012573 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 693974012574 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 693974012575 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 693974012576 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 693974012577 D-pathway; other site 693974012578 Putative ubiquinol binding site [chemical binding]; other site 693974012579 Low-spin heme (heme b) binding site [chemical binding]; other site 693974012580 Putative water exit pathway; other site 693974012581 Binuclear center (heme o3/CuB) [ion binding]; other site 693974012582 K-pathway; other site 693974012583 Putative proton exit pathway; other site 693974012584 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 693974012585 Subunit I/III interface [polypeptide binding]; other site 693974012586 Subunit III/IV interface [polypeptide binding]; other site 693974012587 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 693974012588 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 693974012589 UbiA prenyltransferase family; Region: UbiA; pfam01040 693974012590 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693974012591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974012592 S-adenosylmethionine binding site [chemical binding]; other site 693974012593 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 693974012594 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693974012595 catalytic residues [active] 693974012596 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 693974012597 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693974012598 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 693974012599 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 693974012600 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693974012601 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 693974012602 DsbD alpha interface [polypeptide binding]; other site 693974012603 catalytic residues [active] 693974012604 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693974012605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693974012606 NAD(P) binding site [chemical binding]; other site 693974012607 active site 693974012608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693974012609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693974012610 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 693974012611 putative effector binding pocket; other site 693974012612 putative dimerization interface [polypeptide binding]; other site 693974012613 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 693974012614 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 693974012615 trimer interface [polypeptide binding]; other site 693974012616 active site 693974012617 substrate binding site [chemical binding]; other site 693974012618 CoA binding site [chemical binding]; other site 693974012619 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 693974012620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693974012621 substrate binding pocket [chemical binding]; other site 693974012622 membrane-bound complex binding site; other site 693974012623 hinge residues; other site 693974012624 RNA polymerase sigma factor; Provisional; Region: PRK12528 693974012625 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693974012626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693974012627 DNA binding residues [nucleotide binding] 693974012628 fec operon regulator FecR; Reviewed; Region: PRK09774 693974012629 FecR protein; Region: FecR; pfam04773 693974012630 Secretin and TonB N terminus short domain; Region: STN; smart00965 693974012631 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 693974012632 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974012633 N-terminal plug; other site 693974012634 ligand-binding site [chemical binding]; other site 693974012635 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 693974012636 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 693974012637 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 693974012638 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 693974012639 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 693974012640 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 693974012641 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 693974012642 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 693974012643 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 693974012644 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 693974012645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974012646 S-adenosylmethionine binding site [chemical binding]; other site 693974012647 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 693974012648 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 693974012649 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693974012650 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693974012651 catalytic residue [active] 693974012652 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 693974012653 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 693974012654 AbgT putative transporter family; Region: ABG_transport; pfam03806 693974012655 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 693974012656 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 693974012657 Protein export membrane protein; Region: SecD_SecF; cl14618 693974012658 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 693974012659 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974012660 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974012661 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 693974012662 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 693974012663 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 693974012664 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 693974012665 C-terminal domain interface [polypeptide binding]; other site 693974012666 GSH binding site (G-site) [chemical binding]; other site 693974012667 dimer interface [polypeptide binding]; other site 693974012668 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 693974012669 N-terminal domain interface [polypeptide binding]; other site 693974012670 dimer interface [polypeptide binding]; other site 693974012671 substrate binding pocket (H-site) [chemical binding]; other site 693974012672 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693974012673 active site 693974012674 oligopeptidase A; Provisional; Region: PRK10911 693974012675 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693974012676 active site 693974012677 Zn binding site [ion binding]; other site 693974012678 glutathione reductase; Validated; Region: PRK06116 693974012679 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693974012680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693974012681 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693974012682 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 693974012683 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 693974012684 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693974012685 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974012686 Fusaric acid resistance protein family; Region: FUSC; pfam04632 693974012687 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693974012688 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 693974012689 Na binding site [ion binding]; other site 693974012690 gamma-glutamyl kinase; Provisional; Region: PRK13402 693974012691 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 693974012692 nucleotide binding site [chemical binding]; other site 693974012693 homotetrameric interface [polypeptide binding]; other site 693974012694 putative phosphate binding site [ion binding]; other site 693974012695 putative allosteric binding site; other site 693974012696 PUA domain; Region: PUA; cl00607 693974012697 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 693974012698 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 693974012699 putative catalytic cysteine [active] 693974012700 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693974012701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974012702 non-specific DNA binding site [nucleotide binding]; other site 693974012703 salt bridge; other site 693974012704 sequence-specific DNA binding site [nucleotide binding]; other site 693974012705 Protein of unknown function (DUF3612); Region: DUF3612; pfam12268 693974012706 malate synthase; Provisional; Region: PRK08951 693974012707 Predicted membrane protein [Function unknown]; Region: COG2855 693974012708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693974012709 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 693974012710 DNA binding residues [nucleotide binding] 693974012711 dimerization interface [polypeptide binding]; other site 693974012712 HlyD family secretion protein; Region: HlyD_3; pfam13437 693974012713 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 693974012714 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 693974012715 Paraquat-inducible protein A; Region: PqiA; pfam04403 693974012716 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 693974012717 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 693974012718 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693974012719 Zn2+ binding site [ion binding]; other site 693974012720 Mg2+ binding site [ion binding]; other site 693974012721 Cobalt transport protein; Region: CbiQ; cl00463 693974012722 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 693974012723 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 693974012724 Walker A/P-loop; other site 693974012725 ATP binding site [chemical binding]; other site 693974012726 Q-loop/lid; other site 693974012727 ABC transporter signature motif; other site 693974012728 Walker B; other site 693974012729 D-loop; other site 693974012730 H-loop/switch region; other site 693974012731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974012732 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 693974012733 Walker A/P-loop; other site 693974012734 ATP binding site [chemical binding]; other site 693974012735 Q-loop/lid; other site 693974012736 ABC transporter signature motif; other site 693974012737 Walker B; other site 693974012738 D-loop; other site 693974012739 H-loop/switch region; other site 693974012740 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974012741 N-terminal plug; other site 693974012742 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 693974012743 ligand-binding site [chemical binding]; other site 693974012744 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 693974012745 chorismate binding enzyme; Region: Chorismate_bind; cl10555 693974012746 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 693974012747 hypothetical protein; Provisional; Region: PRK11212 693974012748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693974012749 Coenzyme A binding pocket [chemical binding]; other site 693974012750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693974012751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693974012752 dimer interface [polypeptide binding]; other site 693974012753 phosphorylation site [posttranslational modification] 693974012754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693974012755 ATP binding site [chemical binding]; other site 693974012756 G-X-G motif; other site 693974012757 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693974012758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693974012759 active site 693974012760 phosphorylation site [posttranslational modification] 693974012761 intermolecular recognition site; other site 693974012762 dimerization interface [polypeptide binding]; other site 693974012763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974012764 Walker A motif; other site 693974012765 ATP binding site [chemical binding]; other site 693974012766 Walker B motif; other site 693974012767 arginine finger; other site 693974012768 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693974012769 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693974012770 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693974012771 dimerization interface [polypeptide binding]; other site 693974012772 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693974012773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693974012774 dimer interface [polypeptide binding]; other site 693974012775 conserved gate region; other site 693974012776 putative PBP binding loops; other site 693974012777 ABC-ATPase subunit interface; other site 693974012778 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 693974012779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693974012780 Walker A/P-loop; other site 693974012781 ATP binding site [chemical binding]; other site 693974012782 Q-loop/lid; other site 693974012783 ABC transporter signature motif; other site 693974012784 Walker B; other site 693974012785 D-loop; other site 693974012786 H-loop/switch region; other site 693974012787 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 693974012788 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 693974012789 GTP binding site; other site 693974012790 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491 693974012791 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 693974012792 Walker A motif; other site 693974012793 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 693974012794 dimer interface [polypeptide binding]; other site 693974012795 putative functional site; other site 693974012796 putative MPT binding site; other site 693974012797 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 693974012798 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974012799 FeS/SAM binding site; other site 693974012800 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 693974012801 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 693974012802 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 693974012803 DNA binding site [nucleotide binding] 693974012804 catalytic residue [active] 693974012805 H2TH interface [polypeptide binding]; other site 693974012806 putative catalytic residues [active] 693974012807 turnover-facilitating residue; other site 693974012808 intercalation triad [nucleotide binding]; other site 693974012809 8OG recognition residue [nucleotide binding]; other site 693974012810 putative reading head residues; other site 693974012811 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 693974012812 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693974012813 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693974012814 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 693974012815 Ligand binding site; other site 693974012816 Putative Catalytic site; other site 693974012817 DXD motif; other site 693974012818 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 693974012819 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693974012820 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 693974012821 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 693974012822 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693974012823 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 693974012824 putative NAD(P) binding site [chemical binding]; other site 693974012825 active site 693974012826 putative substrate binding site [chemical binding]; other site 693974012827 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 693974012828 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 693974012829 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 693974012830 active site 693974012831 (T/H)XGH motif; other site 693974012832 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 693974012833 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 693974012834 active site 693974012835 homodimer interface [polypeptide binding]; other site 693974012836 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693974012837 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693974012838 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693974012839 active site 693974012840 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306 693974012841 conserved hypothetical protein; Region: MJ1255; TIGR00661 693974012842 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 693974012843 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 693974012844 putative active site [active] 693974012845 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 693974012846 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 693974012847 active site 693974012848 ATP binding site [chemical binding]; other site 693974012849 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 693974012850 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 693974012851 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693974012852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693974012853 Bacterial transcriptional repressor; Region: TetR; pfam13972 693974012854 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 693974012855 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 693974012856 substrate-cofactor binding pocket; other site 693974012857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693974012858 catalytic residue [active] 693974012859 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 693974012860 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693974012861 NAD(P) binding site [chemical binding]; other site 693974012862 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 693974012863 active site residue [active] 693974012864 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 693974012865 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 693974012866 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 693974012867 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 693974012868 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 693974012869 conserved cys residue [active] 693974012870 DNA polymerase I; Provisional; Region: PRK05755 693974012871 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 693974012872 active site 693974012873 metal binding site 1 [ion binding]; metal-binding site 693974012874 putative 5' ssDNA interaction site; other site 693974012875 metal binding site 3; metal-binding site 693974012876 metal binding site 2 [ion binding]; metal-binding site 693974012877 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 693974012878 putative DNA binding site [nucleotide binding]; other site 693974012879 putative metal binding site [ion binding]; other site 693974012880 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 693974012881 active site 693974012882 catalytic site [active] 693974012883 substrate binding site [chemical binding]; other site 693974012884 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 693974012885 active site 693974012886 DNA binding site [nucleotide binding] 693974012887 catalytic site [active] 693974012888 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 693974012889 G1 box; other site 693974012890 GTP/Mg2+ binding site [chemical binding]; other site 693974012891 Switch I region; other site 693974012892 G2 box; other site 693974012893 G3 box; other site 693974012894 Switch II region; other site 693974012895 G4 box; other site 693974012896 G5 box; other site 693974012897 Cytochrome c553 [Energy production and conversion]; Region: COG2863 693974012898 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693974012899 Cytochrome c; Region: Cytochrom_C; cl11414 693974012900 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693974012901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693974012902 Der GTPase activator (YihI); Region: YihI; pfam04220 693974012903 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 693974012904 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 693974012905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693974012906 FeS/SAM binding site; other site 693974012907 HemN C-terminal domain; Region: HemN_C; pfam06969 693974012908 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 693974012909 adenosine deaminase; Provisional; Region: PRK09358 693974012910 active site 693974012911 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 693974012912 lysophospholipase L2; Provisional; Region: PRK10749 693974012913 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693974012914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693974012915 PAS fold; Region: PAS_3; pfam08447 693974012916 putative active site [active] 693974012917 heme pocket [chemical binding]; other site 693974012918 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693974012919 metal binding site [ion binding]; metal-binding site 693974012920 active site 693974012921 I-site; other site 693974012922 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693974012923 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 693974012924 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 693974012925 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693974012926 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 693974012927 substrate binding site [chemical binding]; other site 693974012928 oxyanion hole (OAH) forming residues; other site 693974012929 trimer interface [polypeptide binding]; other site 693974012930 Predicted membrane protein [Function unknown]; Region: COG3205 693974012931 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 693974012932 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 693974012933 glutaminase active site [active] 693974012934 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 693974012935 dimer interface [polypeptide binding]; other site 693974012936 active site 693974012937 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693974012938 dimer interface [polypeptide binding]; other site 693974012939 active site 693974012940 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 693974012941 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 693974012942 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693974012943 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 693974012944 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 693974012945 N-terminal plug; other site 693974012946 ligand-binding site [chemical binding]; other site 693974012947 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 693974012948 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 693974012949 Substrate binding site; other site 693974012950 Mg++ binding site; other site 693974012951 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 693974012952 active site 693974012953 substrate binding site [chemical binding]; other site 693974012954 CoA binding site [chemical binding]; other site 693974012955 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 693974012956 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 693974012957 gamma subunit interface [polypeptide binding]; other site 693974012958 epsilon subunit interface [polypeptide binding]; other site 693974012959 LBP interface [polypeptide binding]; other site 693974012960 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 693974012961 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693974012962 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 693974012963 alpha subunit interaction interface [polypeptide binding]; other site 693974012964 Walker A motif; other site 693974012965 ATP binding site [chemical binding]; other site 693974012966 Walker B motif; other site 693974012967 inhibitor binding site; inhibition site 693974012968 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693974012969 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 693974012970 core domain interface [polypeptide binding]; other site 693974012971 delta subunit interface [polypeptide binding]; other site 693974012972 epsilon subunit interface [polypeptide binding]; other site 693974012973 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 693974012974 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693974012975 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 693974012976 beta subunit interaction interface [polypeptide binding]; other site 693974012977 Walker A motif; other site 693974012978 ATP binding site [chemical binding]; other site 693974012979 Walker B motif; other site 693974012980 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693974012981 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 693974012982 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 693974012983 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 693974012984 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 693974012985 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 693974012986 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 693974012987 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 693974012988 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 693974012989 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 693974012990 ParB-like nuclease domain; Region: ParBc; pfam02195 693974012991 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693974012992 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693974012993 P-loop; other site 693974012994 Magnesium ion binding site [ion binding]; other site 693974012995 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693974012996 Magnesium ion binding site [ion binding]; other site 693974012997 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 693974012998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693974012999 S-adenosylmethionine binding site [chemical binding]; other site 693974013000 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 693974013001 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 693974013002 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 693974013003 FMN-binding protein MioC; Provisional; Region: PRK09004 693974013004 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 693974013005 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 693974013006 trmE is a tRNA modification GTPase; Region: trmE; cd04164 693974013007 G1 box; other site 693974013008 GTP/Mg2+ binding site [chemical binding]; other site 693974013009 Switch I region; other site 693974013010 G2 box; other site 693974013011 Switch II region; other site 693974013012 G3 box; other site 693974013013 G4 box; other site 693974013014 G5 box; other site 693974013015 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 693974013016 membrane protein insertase; Provisional; Region: PRK01318 693974013017 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 693974013018 Haemolytic domain; Region: Haemolytic; pfam01809 693974013019 ribonuclease P; Reviewed; Region: rnpA; PRK01732 693974013020 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 693974013021 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693974013022 AAA ATPase domain; Region: AAA_16; pfam13191 693974013023 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 693974013024 H-NS histone family; Region: Histone_HNS; pfam00816 693974013025 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 693974013026 ParB-like nuclease domain; Region: ParBc; pfam02195 693974013027 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 693974013028 HicB family; Region: HicB; pfam05534 693974013029 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 693974013030 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 693974013031 Protein of unknown function, DUF462; Region: DUF462; cl01190 693974013032 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 693974013033 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 693974013034 AAA domain; Region: AAA_30; pfam13604 693974013035 Toprim domain; Region: Toprim_3; pfam13362 693974013036 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 693974013037 F sex factor protein N terminal; Region: TraD_N; pfam12615 693974013038 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693974013039 Walker A motif; other site 693974013040 ATP binding site [chemical binding]; other site 693974013041 Walker B motif; other site 693974013042 F sex factor protein N terminal; Region: TraD_N; pfam12615 693974013043 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 693974013044 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 693974013045 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 693974013046 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693974013047 catalytic residues [active] 693974013048 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 693974013049 F plasmid transfer operon protein; Region: TraF; pfam13728 693974013050 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 693974013051 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 693974013052 TraU protein; Region: TraU; cl06067 693974013053 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 693974013054 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677 693974013055 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 693974013056 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 693974013057 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693974013058 Walker A motif; other site 693974013059 ATP binding site [chemical binding]; other site 693974013060 type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747 693974013061 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 693974013062 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 693974013063 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 693974013064 TraK protein; Region: TraK; pfam06586 693974013065 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 693974013066 TraE protein; Region: TraE; pfam05309 693974013067 TraL protein; Region: TraL; pfam07178 693974013068 type IV conjugative transfer system pilin TraA; Region: TraA_TIGR; TIGR02758 693974013069 TraY domain; Region: TraY; pfam05509 693974013070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693974013071 non-specific DNA binding site [nucleotide binding]; other site 693974013072 salt bridge; other site 693974013073 sequence-specific DNA binding site [nucleotide binding]; other site 693974013074 Predicted transcriptional regulator [Transcription]; Region: COG2932 693974013075 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693974013076 Catalytic site [active] 693974013077 Hok/gef family; Region: HOK_GEF; pfam01848 693974013078 ParA-like protein; Provisional; Region: PHA02518 693974013079 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693974013080 P-loop; other site 693974013081 Magnesium ion binding site [ion binding]; other site 693974013082 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693974013083 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 693974013084 catalytic residues [active] 693974013085 catalytic nucleophile [active] 693974013086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693974013087 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693974013088 Walker A motif; other site 693974013089 ATP binding site [chemical binding]; other site 693974013090 Walker B motif; other site