-- dump date 20140620_053821 -- class Genbank::CDS -- table cds_note -- id note YP_002043841.1 identified by glimmer; putative YP_002043843.1 identified by glimmer; putative YP_002043846.1 identified by match to protein family HMM PF05016 YP_002043847.1 identified by match to protein family HMM PF00929 YP_002043849.1 identified by glimmer; putative YP_002043850.1 identified by glimmer; putative YP_002043854.1 identified by glimmer; putative YP_002043856.1 identified by glimmer; putative YP_002043857.1 identified by match to protein family HMM PF01024 YP_002043859.1 identified by glimmer; putative YP_002043863.1 identified by glimmer; putative YP_002043865.1 identified by glimmer; putative YP_002043867.1 identified by glimmer; putative YP_002043869.1 identified by match to protein family HMM PF00589 YP_002043872.1 identified by match to protein family HMM PF06406 YP_002043874.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_002043875.1 identified by match to protein family HMM PF00717 YP_002043876.1 identified by match to protein family HMM PF06183 YP_002043877.1 identified by glimmer; putative YP_002043878.1 identified by glimmer; putative YP_002043879.1 identified by match to protein family HMM PF06924 YP_002043881.1 identified by match to protein family HMM PF01555 YP_002043883.1 identified by match to protein family HMM PF07128 YP_002043885.1 identified by match to protein family HMM PF03230 YP_002043888.1 identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621 YP_002043889.1 identified by match to protein family HMM PF06006 YP_002043890.1 identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180 YP_002043891.1 identified by match to protein family HMM PF06290 YP_002043892.1 PsiA YP_002043895.1 identified by match to protein family HMM PF07275 YP_002043896.1 identified by glimmer; putative YP_002043897.1 identified by glimmer; putative YP_002043900.1 identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784 YP_002043907.1 identified by glimmer; putative YP_002043908.1 identified by match to protein family HMM PF01402 YP_002043909.1 identified by match to protein family HMM PF03432 YP_002043913.1 identified by match to protein family HMM PF01848 YP_002043916.1 identified by glimmer; putative YP_002043933.1 identified by match to protein family HMM PF01751 YP_002043936.1 identified by match to protein family HMM PF00437; match to protein family HMM TIGR02525 YP_002043939.1 identified by glimmer; putative YP_002043940.1 identified by match to protein family HMM PF00300 YP_002043943.1 identified by match to protein family HMM PF00589 YP_002043944.1 identified by match to protein family HMM PF04917 YP_002043945.1 identified by match to protein family HMM PF01478 YP_002043946.1 identified by match to protein family HMM PF01464 YP_002043947.1 identified by match to protein family HMM PF08805 YP_002043948.1 identified by match to protein family HMM PF00482 YP_002043949.1 identified by match to protein family HMM PF00437 YP_002043950.1 identified by match to protein family HMM TIGR03021 YP_002043951.1 identified by match to protein family HMM PF06864 YP_002043952.1 identified by match to protein family HMM PF00263; match to protein family HMM PF07655; match to protein family HMM TIGR02520 YP_002043953.1 identified by match to protein family HMM PF07419 YP_002043956.1 identified by glimmer; putative YP_002043958.1 identified by glimmer; putative YP_002043960.1 identified by glimmer; putative YP_002043963.1 identified by glimmer; putative YP_002043964.1 identified by glimmer; putative YP_002043965.1 identified by match to protein family HMM PF08281 YP_002043966.1 identified by match to protein family HMM PF01815 YP_002043967.1 identified by glimmer; putative YP_002043968.1 identified by match to protein family HMM PF03432 YP_002043969.1 identified by glimmer; putative YP_002043970.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_002043971.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_002043972.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_002043973.1 identified by match to protein family HMM PF03883 YP_002043974.1 identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835 YP_002043975.1 identified by match to protein family HMM PF00923; match to protein family HMM TIGR00874 YP_002043976.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_002043977.1 identified by match to protein family HMM PF01184 YP_002043978.1 identified by match to protein family HMM PF03667 YP_002043980.1 identified by glimmer; putative YP_002043981.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_002043982.1 'chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion' YP_002043983.1 identified by glimmer; putative YP_002043984.1 identified by match to protein family HMM PF00126 YP_002043986.1 identified by match to protein family HMM PF05838; match to protein family HMM PF09374 YP_002043988.1 identified by match to protein family HMM PF00704; match to protein family HMM PF02839 YP_002043991.1 identified by match to protein family HMM PF01609 YP_002043992.1 identified by match to protein family HMM PF00419 YP_002043993.2 identified by match to protein family HMM PF00345; match to protein family HMM PF02753 YP_002043994.1 identified by match to protein family HMM PF00577 YP_002043995.1 identified by match to protein family HMM PF00419 YP_002043996.1 identified by match to protein family HMM PF00419 YP_002043997.1 identified by match to protein family HMM PF00419 YP_002043998.2 identified by match to protein family HMM PF00345; match to protein family HMM PF02753 YP_002043999.1 identified by match to protein family HMM PF01323 YP_002044001.1 identified by glimmer; putative YP_002044002.1 identified by match to protein family HMM PF07135 YP_002044003.1 identified by match to protein family HMM PF00884 YP_002044004.1 identified by match to protein family HMM PF04055 YP_002044006.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_002044007.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC YP_002044008.1 identified by match to protein family HMM PF01055 YP_002044009.1 identified by match to protein family HMM TIGR00792 YP_002044010.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_002044011.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_002044012.1 'IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme' YP_002044013.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_002044014.1 identified by glimmer; putative YP_002044015.1 identified by match to protein family HMM PF00254 YP_002044016.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_002044018.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides YP_002044019.1 identified by match to protein family HMM PF00072 YP_002044020.1 identified by match to protein family HMM PF02518 YP_002044021.1 identified by match to protein family HMM PF03977; match to protein family HMM TIGR01109 YP_002044022.1 catalyzes the formation of pyruvate from oxaloacetate YP_002044023.1 catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide YP_002044024.1 identified by match to protein family HMM PF03390; match to protein family HMM TIGR00783 YP_002044025.1 identified by match to protein family HMM PF00583; match to protein family HMM PF08218; match to protein family HMM TIGR00124; match to protein family HMM TIGR00125 YP_002044026.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_002044027.1 identified by match to protein family HMM PF03328; match to protein family HMM TIGR01588 YP_002044028.1 identified by match to protein family HMM PF04223; match to protein family HMM TIGR01584 YP_002044029.1 identified by match to protein family HMM PF03802; match to protein family HMM TIGR03124 YP_002044030.1 identified by match to protein family HMM PF01874; match to protein family HMM TIGR03125 YP_002044031.1 'catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis' YP_002044033.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002044034.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_002044035.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities YP_002044036.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA YP_002044037.1 identified by match to protein family HMM PF00501 YP_002044038.1 'catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine' YP_002044039.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA YP_002044040.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism YP_002044041.1 identified by glimmer; putative YP_002044043.1 'required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase' YP_002044044.1 involved in electron transfer during carnitine metabolism YP_002044045.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction YP_002044047.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690 YP_002044048.1 identified by match to protein family HMM PF06004 YP_002044050.1 identified by match to protein family HMM PF07338 YP_002044051.1 identified by match to protein family HMM PF00884; match to protein family HMM TIGR01409 YP_002044052.1 'Required for full activity of KefC, a potassium-proton antiporter' YP_002044053.1 transport system that facilitates potassium-efflux YP_002044054.1 identified by glimmer; putative YP_002044055.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate YP_002044056.1 'hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP' YP_002044057.1 protein associated with Co2+ and Mg2+ efflux YP_002044058.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_002044059.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_002044060.1 'Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB' YP_002044061.1 determines N-hexane tolerance and is involved in outer membrane permeability YP_002044062.1 identified by glimmer; putative YP_002044063.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_002044064.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs YP_002044065.2 'transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA' YP_002044066.1 'Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C' YP_002044067.2 identified by match to protein family HMM PF02698 YP_002044069.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_002044070.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_002044071.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_002044072.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose YP_002044073.1 identified by match to protein family HMM PF09335 YP_002044074.1 with TbpA and ThiP is part of the thiamine and TPP transport system YP_002044075.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_002044076.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_002044078.1 activates sgrS under glucose-phosphate stress conditions YP_002044079.1 identified by glimmer; putative YP_002044080.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_002044081.1 'dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate' YP_002044082.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_002044083.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_002044084.1 activator for leuABCD operon; member of LysR family of transcriptional activators YP_002044085.1 'catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive' YP_002044086.1 'with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit' YP_002044087.1 identified by glimmer; putative YP_002044088.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_002044089.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_002044090.1 identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006 YP_002044091.1 membrane bound cell division protein at septum containing leucine zipper motif YP_002044092.1 identified by match to protein family HMM PF00905; match to protein family HMM PF03717 YP_002044093.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_002044094.1 identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01143 YP_002044095.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_002044096.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_002044097.1 integral membrane protein involved in stabilizing FstZ ring during cell division YP_002044098.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_002044099.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_002044100.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002044101.1 involved in septum formation YP_002044102.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane YP_002044103.1 'GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function' YP_002044104.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_002044105.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_002044106.1 identified by match to protein family HMM PF00293; match to protein family HMM TIGR00586 YP_002044108.1 identified by match to protein family HMM PF03884 YP_002044109.1 identified by match to protein family HMM PF07072 YP_002044110.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_002044111.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate YP_002044112.1 identified by match to protein family HMM PF00482 YP_002044113.1 identified by match to protein family HMM PF00437 YP_002044114.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532 YP_002044115.1 'catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide' YP_002044116.1 identified by match to protein family HMM PF01510 YP_002044117.1 involved in regulation of beta-lactamase; putative signaling protein YP_002044118.1 identified by match to protein family HMM PF04616 YP_002044119.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00792 YP_002044120.1 identified by match to protein family HMM PF00324 YP_002044121.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex YP_002044122.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_002044123.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains YP_002044124.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002044125.1 identified by glimmer; putative YP_002044129.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_002044131.1 identified by glimmer; putative YP_002044132.1 identified by glimmer; putative YP_002044134.1 identified by glimmer; putative YP_002044136.1 might be involved in hypersensitivity to nitrofurzone YP_002044138.1 identified by match to protein family HMM PF06062 YP_002044139.1 transports degraded pectin products into the bacterial cell YP_002044140.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_002044141.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220 YP_002044142.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_002044143.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_002044145.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification YP_002044146.2 identified by match to protein family HMM PF01011; match to protein family HMM TIGR03074 YP_002044147.1 identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203 YP_002044148.1 catalyzes the interconversion of bicarbonate and carbon dioxide YP_002044149.1 identified by match to protein family HMM PF00005 YP_002044150.1 identified by match to protein family HMM PF01061 YP_002044151.1 identified by match to protein family HMM PF00419 YP_002044152.1 identified by match to protein family HMM PF00577 YP_002044153.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753 YP_002044154.1 identified by match to protein family HMM PF00419 YP_002044155.1 identified by glimmer; putative YP_002044156.1 identified by match to protein family HMM PF03610 YP_002044157.1 identified by match to protein family HMM PF01522 YP_002044158.1 identified by match to protein family HMM PF00419 YP_002044159.1 identified by match to protein family HMM PF00419 YP_002044161.1 identified by match to protein family HMM PF00419 YP_002044162.1 similar to the fimbrial usher protein PapC YP_002044163.1 identified by match to protein family HMM PF00345 YP_002044164.1 identified by match to protein family HMM PF00419 YP_002044165.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_002044166.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_002044167.1 'catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate' YP_002044168.1 'catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP' YP_002044169.2 Polymerase that creates the 3' poly(A) tail found in some mRNA's YP_002044170.1 'this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu' YP_002044171.1 identified by match to protein family HMM PF01258; match to protein family HMM TIGR02420 YP_002044172.1 Regulatory factor involved in maltose metabolism YP_002044173.1 identified by match to protein family HMM PF02834; match to protein family HMM TIGR02258 YP_002044174.1 similar in sequence to the ATP-dependent RNA helicase HrpA YP_002044175.1 'bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell' YP_002044176.1 identified by glimmer; putative YP_002044177.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein YP_002044178.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter YP_002044179.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores YP_002044180.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_002044181.1 identified by glimmer; putative YP_002044182.1 identified by glimmer; putative YP_002044183.1 identified by glimmer; putative YP_002044184.1 identified by match to protein family HMM PF00419 YP_002044185.1 identified by match to protein family HMM PF00577 YP_002044186.1 identified by match to protein family HMM PF00345 YP_002044188.1 identified by match to protein family HMM PF00419 YP_002044189.1 identified by match to protein family HMM PF00419 YP_002044190.1 identified by glimmer; putative YP_002044192.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_002044193.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation YP_002044194.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_002044195.1 identified by match to protein family HMM PF03458 YP_002044196.1 solute binding component of the vitamin B12 transport system BtuCDF YP_002044197.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_002044198.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate YP_002044199.1 protease Do; required at high temperature; degrades damaged proteins YP_002044200.1 'regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization' YP_002044202.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690 YP_002044203.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_002044204.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_002044205.1 'catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn' YP_002044206.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_002044207.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_002044208.1 Catalyzes the phosphorylation of UMP to UDP YP_002044209.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_002044210.2 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_002044211.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_002044212.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate YP_002044213.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response YP_002044214.1 'part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins' YP_002044215.1 identified by match to protein family HMM PF03938 YP_002044216.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_002044217.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_002044218.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_002044219.1 'catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM' YP_002044220.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_002044221.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_002044222.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_002044223.1 identified by match to protein family HMM PF00182; match to protein family HMM PF00801 YP_002044224.1 identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711 YP_002044225.1 identified by match to protein family HMM PF00903 YP_002044226.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase YP_002044227.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination YP_002044228.1 identified by match to protein family HMM PF06786 YP_002044229.1 identified by match to protein family HMM PF07152 YP_002044230.1 identified by match to protein family HMM PF00472 YP_002044231.1 identified by match to protein family HMM PF04170 YP_002044232.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_002044233.1 identified by match to protein family HMM PF01980; match to protein family HMM TIGR00104 YP_002044235.1 identified by match to protein family HMM PF03180; match to protein family HMM TIGR00363 YP_002044236.1 part of the MetNIQ methionine uptake system YP_002044237.1 part of the metNIQ transport system for methionine YP_002044238.1 'Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate' YP_002044239.1 'catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid' YP_002044240.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002044241.1 identified by match to protein family HMM PF07690 YP_002044242.1 identified by match to protein family HMM PF03372 YP_002044243.1 identified by match to protein family HMM PF01209; match to protein family HMM PF08241; match to protein family HMM PF08242 YP_002044244.2 'catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall' YP_002044245.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione YP_002044246.1 identified by match to protein family HMM PF08241 YP_002044247.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_002044248.1 3'-5' exonuclease of DNA polymerase III YP_002044249.1 identified by match to protein family HMM PF06812 YP_002044250.1 identified by match to protein family HMM PF06996; match to protein family HMM TIGR03347 YP_002044251.1 identified by match to protein family HMM PF05947; match to protein family HMM TIGR03359 YP_002044252.1 identified by match to protein family HMM PF04965; match to protein family HMM TIGR03357 YP_002044253.1 identified by match to protein family HMM PF07024 YP_002044255.1 identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; match to protein family HMM TIGR03345 YP_002044256.1 identified by match to protein family HMM PF05591; match to protein family HMM TIGR03358 YP_002044257.1 identified by match to protein family HMM PF05943; match to protein family HMM TIGR03355 YP_002044259.1 identified by match to protein family HMM PF05638; match to protein family HMM TIGR03344 YP_002044262.1 identified by match to protein family HMM PF05638; match to protein family HMM TIGR03344 YP_002044263.1 identified by match to protein family HMM TIGR03352 YP_002044264.1 identified by match to protein family HMM PF05936; match to protein family HMM TIGR03353 YP_002044265.1 identified by match to protein family HMM PF00691; match to protein family HMM TIGR03349; match to protein family HMM TIGR03350 YP_002044268.1 identified by match to protein family HMM PF06744; match to protein family HMM PF06761; match to protein family HMM TIGR03348 YP_002044274.1 identified by match to protein family HMM PF04524; match to protein family HMM TIGR01646; match to protein family HMM TIGR03361 YP_002044275.1 identified by match to protein family HMM PF08786 YP_002044276.1 identified by match to protein family HMM PF03527; match to protein family HMM PF05488; match to protein family HMM PF05593; match to protein family HMM TIGR01643 YP_002044277.1 identified by glimmer; putative YP_002044279.1 identified by glimmer; putative YP_002044280.1 identified by glimmer; putative YP_002044283.1 identified by match to protein family HMM PF04449 YP_002044285.1 identified by match to protein family HMM PF07434 YP_002044286.1 identified by match to protein family HMM PF01037 YP_002044287.1 identified by glimmer; putative YP_002044289.1 identified by glimmer; putative YP_002044290.1 identified by glimmer; putative YP_002044292.1 identified by match to protein family HMM PF07813 YP_002044293.1 identified by match to protein family HMM PF00795 YP_002044294.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_002044295.1 identified by match to protein family HMM PF00310 YP_002044296.1 identified by match to protein family HMM PF06104 YP_002044297.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_002044298.1 mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY YP_002044299.1 similar to release factor 1 and 2 YP_002044300.1 identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01893 YP_002044301.1 'catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively' YP_002044302.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation YP_002044303.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS YP_002044304.1 identified by match to protein family HMM PF00267 YP_002044306.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_002044307.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_002044308.1 identified by match to protein family HMM PF00589 YP_002044310.1 identified by match to protein family HMM PF04447; match to protein family HMM PF04448 YP_002044312.1 identified by match to protein family HMM PF04447 YP_002044315.1 identified by match to protein family HMM PF04404 YP_002044318.1 identified by match to protein family HMM PF02061 YP_002044323.1 identified by match to protein family HMM PF00717 YP_002044324.1 identified by match to protein family HMM PF05269 YP_002044325.1 identified by match to protein family HMM PF04492; match to protein family HMM TIGR01610 YP_002044326.1 identified by match to protein family HMM PF00772; match to protein family HMM PF03796 YP_002044328.1 identified by match to protein family HMM PF05810 YP_002044331.1 identified by match to protein family HMM PF06322 YP_002044335.1 identified by match to protein family HMM PF00959 YP_002044336.1 identified by match to protein family HMM PF03245 YP_002044341.1 identified by match to protein family HMM PF03237 YP_002044343.1 identified by match to protein family HMM PF09306 YP_002044354.1 identified by match to protein family HMM PF09008; match to protein family HMM PF09251 YP_002044356.1 identified by match to protein family HMM PF00535 YP_002044357.1 identified by match to protein family HMM PF04138 YP_002044359.2 identified by match to protein family HMM PF07690 YP_002044360.1 'dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate' YP_002044361.1 identified by match to protein family HMM PF00694; match to protein family HMM TIGR00171 YP_002044362.1 identified by match to protein family HMM PF01557 YP_002044363.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002044364.1 identified by glimmer; putative YP_002044366.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753 YP_002044367.1 identified by match to protein family HMM PF00419 YP_002044368.1 identified by match to protein family HMM PF00577 YP_002044369.1 identified by match to protein family HMM PF00345 YP_002044370.1 identified by match to protein family HMM PF00419 YP_002044372.1 identified by match to protein family HMM PF00563 YP_002044373.1 identified by match to protein family HMM PF00486 YP_002044375.1 identified by match to protein family HMM PF06316; match to protein family HMM TIGR03304 YP_002044379.1 identified by match to protein family HMM PF02321; match to protein family HMM TIGR01845 YP_002044380.1 identified by match to protein family HMM PF00873; match to protein family HMM TIGR00915 YP_002044381.1 identified by match to protein family HMM PF00529; match to protein family HMM TIGR01730 YP_002044382.1 identified by glimmer; putative YP_002044383.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525 YP_002044384.1 identified by match to protein family HMM PF00376; match to protein family HMM PF09278; match to protein family HMM TIGR02044 YP_002044385.1 identified by match to protein family HMM PF00403 YP_002044387.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690 YP_002044388.1 identified by match to protein family HMM PF01555 YP_002044389.1 identified by match to protein family HMM PF04851; match to protein family HMM PF08774 YP_002044390.1 identified by match to protein family HMM PF01654 YP_002044391.1 identified by match to protein family HMM PF02322; match to protein family HMM TIGR00203 YP_002044393.1 identified by match to protein family HMM PF00165 YP_002044394.1 identified by match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783 YP_002044395.1 identified by match to protein family HMM PF01810; match to protein family HMM TIGR00949 YP_002044396.1 identified by match to protein family HMM PF07338 YP_002044397.1 identified by match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM PF06506; match to protein family HMM TIGR02329 YP_002044398.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_002044399.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_002044400.1 'functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C' YP_002044401.1 'catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent' YP_002044402.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_002044403.1 identified by glimmer; putative YP_002044404.1 identified by glimmer; putative YP_002044405.2 identified by match to protein family HMM PF03797; match to protein family HMM TIGR01414 YP_002044406.1 this protein has no known enzymatic function YP_002044407.1 'in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope' YP_002044408.1 identified by match to protein family HMM PF07759 YP_002044411.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002044412.1 identified by match to protein family HMM PF06904 YP_002044413.1 identified by match to protein family HMM PF07690 YP_002044415.1 identified by glimmer; putative YP_002044416.1 identified by match to protein family HMM PF07769 YP_002044417.1 'catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis' YP_002044418.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_002044419.1 identified by glimmer; putative YP_002044420.1 identified by match to protein family HMM PF02639 YP_002044421.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_002044423.1 identified by match to protein family HMM PF07302 YP_002044424.1 identified by match to protein family HMM PF06865 YP_002044425.1 Required for efficient pilin antigenic variation YP_002044426.1 catalyzes phosphorylation of fructose; cytosolic enzyme YP_002044427.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers YP_002044428.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity YP_002044429.1 'with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity' YP_002044430.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB YP_002044431.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB YP_002044433.1 identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796 YP_002044434.1 'cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation' YP_002044435.1 identified by match to protein family HMM PF00128 YP_002044436.1 identified by match to protein family HMM PF00578; match to protein family HMM PF08534 YP_002044437.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP YP_002044438.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_002044439.1 'Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)' YP_002044440.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_002044441.1 'part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane' YP_002044442.1 'forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF' YP_002044443.1 identified by match to protein family HMM PF00903 YP_002044444.1 identified by match to protein family HMM PF08279 YP_002044445.1 identified by match to protein family HMM PF01844 YP_002044446.1 identified by match to protein family HMM PF03502 YP_002044447.1 identified by glimmer; putative YP_002044449.1 identified by glimmer; putative YP_002044450.1 identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244 YP_002044451.1 'riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil' YP_002044452.1 identified by match to protein family HMM PF00885; match to protein family HMM TIGR00114 YP_002044453.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_002044454.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_002044455.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate YP_002044456.1 identified by match to protein family HMM PF00248 YP_002044457.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_002044458.1 identified by match to protein family HMM PF00348 YP_002044459.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_002044460.1 Required for the synthesis of the thiazole moiety YP_002044461.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR03255 YP_002044462.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR03226 YP_002044463.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08402; match to protein family HMM TIGR03258 YP_002044464.1 identified by match to protein family HMM PF01547; match to protein family HMM TIGR03227 YP_002044465.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM TIGR03337 YP_002044466.1 catalyzes the formation of phosphonoacetaldehyde from 2-aminoethylphosphonate and pyruvate YP_002044467.1 catalyzes the degradation of phosphonoacetaldehyde to acetaldehyde and phosphate YP_002044468.1 identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383 YP_002044469.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_002044470.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_002044471.1 identified by match to protein family HMM PF07690 YP_002044472.1 identified by match to protein family HMM PF08238 YP_002044473.1 identified by match to protein family HMM PF08238 YP_002044474.1 converts protoheme IX and farnesyl diphosphate to heme O YP_002044475.1 identified by match to protein family HMM PF03626; match to protein family HMM TIGR02847 YP_002044476.1 identified by match to protein family HMM PF00510; match to protein family HMM TIGR02842 YP_002044477.1 identified by match to protein family HMM PF00115; match to protein family HMM TIGR02843 YP_002044478.1 identified by match to protein family HMM PF00116; match to protein family HMM PF06481; match to protein family HMM TIGR01433 YP_002044479.1 identified by glimmer; putative YP_002044480.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein YP_002044481.1 'positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress' YP_002044482.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_002044483.1 'hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates' YP_002044484.1 binds and unfolds substrates as part of the ClpXP protease YP_002044485.1 identified by match to protein family HMM PF00004; match to protein family HMM PF02190; match to protein family HMM PF05362; match to protein family HMM PF07728; match to protein family HMM TIGR00763 YP_002044486.1 histone-like DNA-binding protein YP_002044487.1 identified by match to protein family HMM PF00639 YP_002044488.1 identified by match to protein family HMM TIGR00426 YP_002044489.1 identified by match to protein family HMM PF03061; match to protein family HMM TIGR00051 YP_002044490.1 'YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His' YP_002044491.1 identified by match to protein family HMM PF00496 YP_002044492.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484 YP_002044493.1 identified by match to protein family HMM PF00291 YP_002044494.1 identified by match to protein family HMM PF01037 YP_002044495.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664 YP_002044496.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664 YP_002044497.1 'indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.' YP_002044498.1 identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836 YP_002044499.1 identified by match to protein family HMM PF02551; match to protein family HMM TIGR00189 YP_002044501.1 identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589 YP_002044502.1 identified by match to protein family HMM PF00563 YP_002044503.1 'RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome' YP_002044504.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_002044506.1 identified by match to protein family HMM PF00132 YP_002044507.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins YP_002044509.1 identified by match to protein family HMM PF00873; match to protein family HMM TIGR00915 YP_002044510.1 identified by match to protein family HMM PF00529; match to protein family HMM TIGR01730 YP_002044511.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine YP_002044512.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_002044514.1 'PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks' YP_002044515.1 identified by match to protein family HMM PF04304 YP_002044516.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_002044517.1 'catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA' YP_002044518.1 identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103 YP_002044519.1 'involved in a recombinational process of DNA repair, independent of the recBC complex' YP_002044520.1 molecular chaperone YP_002044521.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_002044523.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_002044524.1 identified by match to protein family HMM PF00294 YP_002044525.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein YP_002044526.1 identified by match to protein family HMM PF07690 YP_002044527.1 'catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides' YP_002044528.1 identified by match to protein family HMM PF04073; match to protein family HMM TIGR00011 YP_002044529.1 identified by match to protein family HMM PF07446 YP_002044531.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525 YP_002044532.1 activator of copper-responsive regulon genes YP_002044533.1 identified by match to protein family HMM PF01957 YP_002044534.1 identified by match to protein family HMM PF01145 YP_002044535.1 identified by match to protein family HMM PF00005 YP_002044536.1 identified by match to protein family HMM PF03649; match to protein family HMM TIGR00245 YP_002044537.1 identified by match to protein family HMM PF00085 YP_002044538.1 identified by match to protein family HMM PF00106; match to protein family HMM PF08659 YP_002044539.1 identified by match to protein family HMM PF00657 YP_002044540.1 identified by match to protein family HMM PF00005 YP_002044541.1 identified by match to protein family HMM PF02687 YP_002044543.1 identified by match to protein family HMM PF03180 YP_002044544.1 identified by match to protein family HMM PF00005; match to protein family HMM PF09383 YP_002044545.1 identified by match to protein family HMM PF00528 YP_002044546.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_002044547.1 activator of the allDC-ylbA operon involved in allantoin utilization YP_002044548.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_002044549.1 regulates operons involved in the utilization of allantoin YP_002044550.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate YP_002044551.1 identified by match to protein family HMM PF01261; match to protein family HMM TIGR03234 YP_002044552.1 identified by match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR01505 YP_002044553.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690 YP_002044554.1 identified by match to protein family HMM PF02133; match to protein family HMM TIGR00800 YP_002044555.1 Plays a crucial role on both purine and pyrimidine metabolism YP_002044556.1 identified by match to protein family HMM PF00860 YP_002044557.1 identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045 YP_002044558.1 identified by match to protein family HMM PF05899; match to protein family HMM PF07883; match to protein family HMM TIGR03214 YP_002044559.1 'allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide' YP_002044560.1 identified by match to protein family HMM PF02615; match to protein family HMM TIGR03175 YP_002044561.1 identified by glimmer; putative YP_002044562.1 multicopy suppressor of dominant negative ftsH mutations YP_002044563.1 identified by match to protein family HMM PF06545 YP_002044565.1 identified by match to protein family HMM PF00696; match to protein family HMM TIGR00746 YP_002044566.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_002044567.1 identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162 YP_002044568.1 'catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine' YP_002044569.1 identified by match to protein family HMM PF00160 YP_002044570.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002044573.1 identified by match to protein family HMM PF04307 YP_002044575.1 'catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate' YP_002044576.1 identified by glimmer; putative YP_002044577.1 identified by match to protein family HMM PF01609 YP_002044578.1 identified by match to protein family HMM PF00419 YP_002044579.1 identified by match to protein family HMM PF00419 YP_002044580.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753 YP_002044581.1 identified by match to protein family HMM PF00577 YP_002044583.1 identified by match to protein family HMM PF00419 YP_002044584.1 activates the production of the major fimbrae protein FimA YP_002044586.1 identified by glimmer; putative YP_002044589.1 identified by glimmer; putative YP_002044591.1 identified by match to protein family HMM PF00535 YP_002044592.1 identified by match to protein family HMM PF04138 YP_002044594.1 identified by match to protein family HMM PF00165 YP_002044595.1 Involved in disulfide oxidoreductase activity and electron transport YP_002044596.1 identified by match to protein family HMM PF07338 YP_002044597.1 identified by match to protein family HMM PF04224 YP_002044599.1 identified by match to protein family HMM PF00324 YP_002044600.1 identified by match to protein family HMM PF00924 YP_002044602.1 identified by match to protein family HMM PF00657; match to protein family HMM PF03797; match to protein family HMM TIGR01414 YP_002044603.2 identified by match to protein family HMM PF00158; match to protein family HMM PF00874; match to protein family HMM PF07728 YP_002044604.1 identified by match to protein family HMM PF01380 YP_002044605.1 identified by match to protein family HMM PF01380 YP_002044606.1 identified by match to protein family HMM PF03613 YP_002044607.1 identified by match to protein family HMM PF03609 YP_002044608.1 identified by match to protein family HMM PF03830 YP_002044609.1 identified by match to protein family HMM PF03610 YP_002044610.1 'catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive' YP_002044611.1 identified by match to protein family HMM PF04237 YP_002044612.1 identified by match to protein family HMM PF00440 YP_002044613.1 identified by match to protein family HMM PF00165 YP_002044615.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity YP_002044616.1 identified by match to protein family HMM PF01648 YP_002044617.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_002044618.1 identified by match to protein family HMM PF00756 YP_002044619.1 identified by match to protein family HMM PF03621 YP_002044620.1 'with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin' YP_002044621.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake YP_002044622.1 with FepBDE is involved in the transport of ferric enterobactin YP_002044623.1 with FepBCD is involved in the transport of ferric enterobactin YP_002044624.1 with FepBCG is involved in the transport of ferric enterobactin YP_002044625.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters YP_002044626.1 with FepCDG is involved in the transport of ferric enterobactin YP_002044627.1 identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543 YP_002044628.1 'bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate' YP_002044629.1 identified by match to protein family HMM PF00550; match to protein family HMM PF00857 YP_002044630.1 'catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin' YP_002044631.1 identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369 YP_002044632.1 identified by match to protein family HMM PF02554 YP_002044633.1 identified by match to protein family HMM PF04328 YP_002044634.1 member of the iron-containing alcohol dehydrogenase family; unknown function YP_002044635.1 catalyzes the transfer of an amino moiety YP_002044636.1 identified by match to protein family HMM PF02195 YP_002044637.1 identified by match to protein family HMM PF01507 YP_002044638.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002044639.2 Involved in disulfide bond formation YP_002044640.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate YP_002044641.1 identified by match to protein family HMM PF06192 YP_002044642.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409 YP_002044643.1 identified by match to protein family HMM PF00037 YP_002044646.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240 YP_002044647.1 'Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation' YP_002044649.1 identified by match to protein family HMM PF00939; match to protein family HMM TIGR00785 YP_002044650.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA YP_002044651.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate YP_002044652.1 identified by match to protein family HMM PF04223; match to protein family HMM TIGR01584 YP_002044653.1 identified by match to protein family HMM PF03328; match to protein family HMM TIGR01588 YP_002044654.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_002044655.1 identified by match to protein family HMM PF00583; match to protein family HMM PF08218; match to protein family HMM TIGR00124; match to protein family HMM TIGR00125 YP_002044656.1 identified by glimmer; putative YP_002044657.1 identified by glimmer; putative YP_002044658.1 identified by match to protein family HMM PF02518 YP_002044659.1 regulates the expression of citAB in citrate fermentation YP_002044660.1 responsible for the transport of C4-dicarboxylates during anaerobic growth YP_002044661.1 catalyzes the transfer of palmitate to lipid A YP_002044662.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator YP_002044663.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_002044664.1 identified by match to protein family HMM PF00795 YP_002044665.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_002044666.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_002044667.1 identified by glimmer; putative YP_002044668.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002044669.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_002044670.1 identified by match to protein family HMM PF04359 YP_002044671.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors YP_002044672.1 identified by match to protein family HMM PF03330; match to protein family HMM PF05036; match to protein family HMM TIGR00413 YP_002044673.1 identified by match to protein family HMM PF01098; match to protein family HMM TIGR02210 YP_002044674.1 identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM TIGR03423 YP_002044675.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_002044676.1 identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090 YP_002044677.1 identified by match to protein family HMM PF00300; match to protein family HMM TIGR03162 YP_002044678.1 'cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase' YP_002044679.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_002044680.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_002044681.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane YP_002044682.1 'leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase' YP_002044683.1 identified by glimmer; putative YP_002044684.1 identified by match to protein family HMM PF08666 YP_002044685.1 identified by match to protein family HMM PF04295 YP_002044686.1 transports degraded pectin products into the bacterial cell YP_002044687.1 identified by match to protein family HMM PF00158; match to protein family HMM PF06506 YP_002044688.1 identified by match to protein family HMM PF07295 YP_002044689.1 identified by match to protein family HMM PF08238 YP_002044690.1 identified by match to protein family HMM PF06889 YP_002044691.1 identified by match to protein family HMM PF00226 YP_002044692.1 identified by match to protein family HMM PF06889 YP_002044693.1 identified by match to protein family HMM PF00226 YP_002044694.1 identified by match to protein family HMM PF00012 YP_002044696.1 'Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific' YP_002044697.1 identified by match to protein family HMM PF00005 YP_002044698.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_002044699.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_002044700.1 identified by match to protein family HMM PF00497 YP_002044701.1 Transfers the fatty acyl group on membrane lipoproteins YP_002044702.1 identified by match to protein family HMM PF00571; match to protein family HMM PF03471 YP_002044703.1 identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043 YP_002044704.1 identified by match to protein family HMM PF02562 YP_002044705.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_002044706.1 'catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q' YP_002044708.1 identified by glimmer; putative YP_002044709.1 'functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP' YP_002044710.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01460 YP_002044711.1 identified by match to protein family HMM PF00480 YP_002044712.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate YP_002044713.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_002044714.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002044715.1 'catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA' YP_002044716.1 identified by glimmer; putative YP_002044717.1 identified by match to protein family HMM PF03573 YP_002044719.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883 YP_002044720.1 identified by match to protein family HMM TIGR02484 YP_002044721.1 catalyzes the oxidation of tricarballylate to cis-aconitate; FAD-dependent; required for the utilization of tricarballylate as a carbon and energy source by S. enterica YP_002044722.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002044723.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer YP_002044724.1 'An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group' YP_002044725.1 identified by match to protein family HMM PF01402 YP_002044726.1 identified by glimmer; putative YP_002044727.1 identified by match to protein family HMM PF00561; match to protein family HMM PF07819 YP_002044728.1 negative modulator of the initiation of chromosome replication YP_002044729.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_002044731.1 'catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system' YP_002044732.1 identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711 YP_002044734.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport YP_002044735.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein YP_002044736.1 'One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex' YP_002044737.1 'One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions' YP_002044738.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002044740.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent YP_002044741.1 identified by match to protein family HMM PF00854; match to protein family HMM PF07690; match to protein family HMM TIGR00924 YP_002044742.1 identified by glimmer; putative YP_002044743.1 identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486 YP_002044744.1 identified by match to protein family HMM PF02682; match to protein family HMM TIGR00370 YP_002044745.1 identified by match to protein family HMM PF02626; match to protein family HMM TIGR00724 YP_002044746.1 identified by match to protein family HMM PF03746 YP_002044748.1 identified by match to protein family HMM PF00589 YP_002044750.1 identified by match to protein family HMM PF03275; match to protein family HMM TIGR00031 YP_002044751.1 identified by match to protein family HMM PF00535 YP_002044753.1 identified by match to protein family HMM PF01061 YP_002044754.1 identified by match to protein family HMM PF00005 YP_002044759.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity YP_002044760.1 identified by match to protein family HMM PF05145; match to protein family HMM TIGR03082 YP_002044761.1 'type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH' YP_002044762.1 identified by match to protein family HMM PF01127; match to protein family HMM TIGR02970 YP_002044763.1 identified by match to protein family HMM TIGR02968 YP_002044764.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_002044765.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_002044766.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_002044767.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_002044768.1 catalyzes the interconversion of succinyl-CoA and succinate YP_002044769.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_002044770.1 identified by glimmer; putative YP_002044771.1 identified by glimmer; putative YP_002044772.1 identified by glimmer; putative YP_002044773.1 identified by glimmer; putative YP_002044774.1 identified by match to protein family HMM PF01654 YP_002044775.1 identified by match to protein family HMM PF02322; match to protein family HMM TIGR00203 YP_002044776.1 identified by match to protein family HMM PF08173; match to protein family HMM TIGR02106 YP_002044777.1 identified by match to protein family HMM PF09600; match to protein family HMM TIGR02112 YP_002044778.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components YP_002044779.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_002044780.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_002044781.1 'inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins' YP_002044782.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_002044783.1 identified by match to protein family HMM PF00691; match to protein family HMM TIGR02802 YP_002044784.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity YP_002044785.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_002044786.1 identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528 YP_002044787.1 involved in zinc efflux across the cytoplasmic membrane YP_002044789.1 'catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive' YP_002044790.1 Catalyzes the reversible hydration of fumaric acid to yield I-malic acid YP_002044791.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002044792.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002044793.1 identified by match to protein family HMM PF00939; match to protein family HMM PF03600; match to protein family HMM PF06808 YP_002044794.1 catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide YP_002044795.1 catalyzes the formation of pyruvate from oxaloacetate YP_002044796.1 identified by match to protein family HMM PF03977; match to protein family HMM TIGR01109 YP_002044798.1 identified by match to protein family HMM PF01032 YP_002044799.1 identified by match to protein family HMM PF00005 YP_002044800.1 '2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate' YP_002044801.1 'catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose' YP_002044802.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_002044803.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P YP_002044804.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01179 YP_002044806.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum YP_002044807.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons YP_002044809.1 with ModCB is involved in the high-affinity transport of molybdate YP_002044810.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_002044811.1 Part of the ABC transporter complex modABC involved in molybdenum import YP_002044812.1 'YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily' YP_002044813.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate YP_002044814.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family YP_002044815.1 'catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway' YP_002044816.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_002044817.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM TIGR02018 YP_002044818.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_002044819.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_002044820.1 YbhB; similar to rat and human kinase inhibitory proteins YP_002044821.1 'catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate' YP_002044822.1 identified by match to protein family HMM PF04055; match to protein family HMM PF06968; match to protein family HMM TIGR00433 YP_002044823.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_002044824.1 'putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth' YP_002044825.1 'DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium' YP_002044826.1 'The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion' YP_002044828.1 identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826 YP_002044829.1 'together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z' YP_002044830.1 identified by match to protein family HMM PF00994; match to protein family HMM TIGR00177; match to protein family HMM TIGR02667 YP_002044831.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_002044832.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_002044833.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_002044834.1 identified by match to protein family HMM PF01027 YP_002044835.1 identified by match to protein family HMM PF01609 YP_002044840.1 identified by match to protein family HMM PF00614 YP_002044841.1 identified by match to protein family HMM PF03372 YP_002044843.1 identified by match to protein family HMM PF01061 YP_002044844.1 identified by match to protein family HMM PF01061 YP_002044845.1 identified by match to protein family HMM PF00005 YP_002044846.1 identified by match to protein family HMM PF00529 YP_002044847.1 identified by match to protein family HMM PF00440; match to protein family HMM PF09209 YP_002044848.1 this helicase is not essential cell growth YP_002044849.1 helicase involved in DNA repair and perhaps also replication YP_002044850.1 identified by match to protein family HMM PF02885 YP_002044851.1 identified by match to protein family HMM PF07338 YP_002044852.1 identified by glimmer; putative YP_002044853.1 identified by match to protein family HMM PF01258 YP_002044854.1 identified by match to protein family HMM PF05971 YP_002044855.1 identified by match to protein family HMM PF00924 YP_002044856.1 similar to ATP-binding component of ABC transporters YP_002044857.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine YP_002044858.1 similar to periplasmic-binding component of ABC transporters YP_002044859.1 identified by glimmer; putative YP_002044860.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage YP_002044862.1 identified by match to protein family HMM PF00892 YP_002044863.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains YP_002044864.1 identified by match to protein family HMM PF00884 YP_002044865.1 identified by glimmer; putative YP_002044866.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present YP_002044867.1 identified by match to protein family HMM PF03600 YP_002044868.1 identified by match to protein family HMM PF03734 YP_002044869.1 identified by match to protein family HMM PF00005 YP_002044870.1 identified by match to protein family HMM PF07350 YP_002044872.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484 YP_002044873.1 identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774 YP_002044874.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494 YP_002044875.1 'ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase' YP_002044876.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum YP_002044877.1 identified by match to protein family HMM PF01112 YP_002044878.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains YP_002044879.1 identified by match to protein family HMM PF00496 YP_002044880.1 identified by match to protein family HMM PF00528 YP_002044881.1 identified by match to protein family HMM PF00528 YP_002044882.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_002044883.1 identified by glimmer; putative YP_002044884.1 'BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing' YP_002044886.1 identified by match to protein family HMM PF01012 YP_002044887.1 identified by match to protein family HMM PF00766; match to protein family HMM PF01012 YP_002044888.1 identified by match to protein family HMM PF00441; match to protein family HMM PF02770; match to protein family HMM PF02771; match to protein family HMM PF08028 YP_002044889.1 identified by match to protein family HMM PF01266; match to protein family HMM PF05187 YP_002044890.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002044892.1 identified by match to protein family HMM PF00043; match to protein family HMM PF02798 YP_002044893.1 'penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains' YP_002044894.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220 YP_002044895.1 identified by match to protein family HMM PF01569 YP_002044896.1 identified by match to protein family HMM PF07690 YP_002044897.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484 YP_002044898.1 identified by match to protein family HMM PF07690 YP_002044899.1 identified by match to protein family HMM PF00440 YP_002044900.1 identified by match to protein family HMM PF02080; match to protein family HMM PF06826; match to protein family HMM TIGR01625 YP_002044902.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_002044903.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function YP_002044904.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds YP_002044905.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 YP_002044907.1 identified by match to protein family HMM PF01547 YP_002044908.1 part of the PotFGHI ATP-dependent putrescine transporter YP_002044909.1 identified by match to protein family HMM PF00528 YP_002044910.1 identified by match to protein family HMM PF00528 YP_002044912.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA YP_002044914.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_002044915.1 identified by match to protein family HMM PF00884 YP_002044917.1 identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096 YP_002044918.1 with ArtPQJI acts to transport arginine across the inner membrane YP_002044919.1 with ArtPMJI transports arginine across the inner membrane YP_002044920.1 identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096 YP_002044921.1 With ArtMQJI transports arginine across the inner membrane YP_002044922.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS YP_002044923.1 identified by match to protein family HMM PF01906 YP_002044924.1 identified by match to protein family HMM PF01510 YP_002044925.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993 YP_002044926.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF05368 YP_002044927.1 'low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine' YP_002044928.1 catalyzes the formation of acetate from pyruvate YP_002044929.1 identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970 YP_002044930.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_002044931.1 identified by match to protein family HMM PF03956 YP_002044933.1 identified by match to protein family HMM PF04393 YP_002044934.1 confers macrolide resistance via active drug efflux YP_002044935.1 with MacA is involved in the export of macrolide YP_002044936.1 identified by glimmer; putative YP_002044937.1 identified by match to protein family HMM PF00313; match to protein family HMM TIGR02381 YP_002044938.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_002044939.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates YP_002044940.1 identified by match to protein family HMM PF01797 YP_002044944.1 identified by match to protein family HMM PF00857 YP_002044945.1 identified by match to protein family HMM PF02678; match to protein family HMM PF05726 YP_002044946.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002044947.1 'stimulates the activities of the other two initiation factors, IF-2 and IF-3' YP_002044948.1 'leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys' YP_002044949.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_002044950.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_002044951.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding YP_002044952.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_002044953.1 DNA-binding membrane protein required for chromosome resolution and partitioning YP_002044954.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_002044955.1 identified by match to protein family HMM PF00004 YP_002044956.1 'catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA' YP_002044957.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR02166 YP_002044958.1 identified by match to protein family HMM PF00037; match to protein family HMM TIGR02951 YP_002044959.1 identified by match to protein family HMM PF04976 YP_002044960.1 identified by match to protein family HMM PF07690 YP_002044961.1 identified by match to protein family HMM PF00324 YP_002044962.1 activates pyruvate formate-lyase 1 under anaerobic conditions YP_002044965.1 identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255 YP_002044966.1 identified by match to protein family HMM PF01226; match to protein family HMM TIGR00790 YP_002044967.1 identified by match to protein family HMM PF02624; match to protein family HMM TIGR00702 YP_002044968.1 identified by match to protein family HMM PF04239 YP_002044969.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_002044970.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_002044971.1 identified by match to protein family HMM PF01435 YP_002044972.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_002044973.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_002044974.1 'This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control' YP_002044975.1 identified by match to protein family HMM PF00753; match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361 YP_002044976.1 involved in the transport of lipid A across the inner membrane YP_002044977.1 'transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate' YP_002044978.1 identified by match to protein family HMM PF06224 YP_002044979.1 identified by match to protein family HMM PF03966 YP_002044980.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_002044982.1 identified by match to protein family HMM PF02698 YP_002044983.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA YP_002044984.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division YP_002044985.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division YP_002044986.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_002044987.1 identified by match to protein family HMM PF01471 YP_002044988.1 identified by match to protein family HMM PF05951; match to protein family HMM PF08291 YP_002044989.1 identified by match to protein family HMM PF00753 YP_002044990.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_002044991.1 identified by match to protein family HMM PF00267 YP_002044992.1 identified by glimmer; putative YP_002044993.1 identified by glimmer; putative YP_002044994.1 'catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA' YP_002044995.1 identified by match to protein family HMM PF01037 YP_002044996.1 identified by glimmer; putative YP_002044997.1 'catalyzes the formation of pyruvate from 2,3-diaminopropionate' YP_002044999.1 identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835 YP_002045000.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_002045001.1 identified by match to protein family HMM PF00589 YP_002045002.1 identified by match to protein family HMM PF06806 YP_002045004.1 identified by match to protein family HMM PF02086; match to protein family HMM TIGR00571 YP_002045005.1 identified by match to protein family HMM PF09588 YP_002045006.1 identified by match to protein family HMM PF03837; match to protein family HMM TIGR01913 YP_002045007.1 identified by match to protein family HMM PF06064 YP_002045008.1 Rac prophage Kil protein; Kil overexpression leads to morphological defects and inhibits cell division YP_002045013.1 identified by match to protein family HMM PF04492; match to protein family HMM TIGR01610 YP_002045014.1 identified by match to protein family HMM PF06992 YP_002045018.1 identified by match to protein family HMM PF01609 YP_002045020.2 identified by glimmer; putative YP_002045021.1 identified by match to protein family HMM PF06183 YP_002045023.1 identified by match to protein family HMM PF07105 YP_002045025.1 identified by match to protein family HMM PF05766 YP_002045027.1 identified by glimmer; putative YP_002045028.1 identified by glimmer; putative YP_002045030.1 identified by match to protein family HMM PF00959 YP_002045032.1 identified by match to protein family HMM PF03245 YP_002045033.1 identified by match to protein family HMM PF07278 YP_002045034.1 identified by match to protein family HMM PF05876 YP_002045036.1 identified by match to protein family HMM PF05136; match to protein family HMM TIGR01539 YP_002045037.1 identified by match to protein family HMM PF00574 YP_002045040.1 identified by match to protein family HMM PF06763 YP_002045041.1 identified by match to protein family HMM PF06141 YP_002045042.1 identified by match to protein family HMM PF02368 YP_002045043.1 identified by match to protein family HMM PF06894; match to protein family HMM TIGR01674 YP_002045044.1 identified by match to protein family HMM PF06223; match to protein family HMM TIGR01715 YP_002045045.1 identified by match to protein family HMM PF06791; match to protein family HMM PF09718; match to protein family HMM TIGR01541 YP_002045046.1 identified by match to protein family HMM PF05939 YP_002045047.1 identified by match to protein family HMM PF06316 YP_002045048.1 identified by match to protein family HMM PF00080 YP_002045049.1 identified by match to protein family HMM PF05100; match to protein family HMM TIGR01600 YP_002045050.1 identified by match to protein family HMM PF00877 YP_002045051.1 identified by match to protein family HMM PF06805 YP_002045052.1 identified by match to protein family HMM PF00041; match to protein family HMM PF09327 YP_002045054.1 identified by match to protein family HMM PF03406; match to protein family HMM PF07484; match to protein family HMM PF08400 YP_002045055.1 identified by match to protein family HMM PF02413 YP_002045056.1 identified by match to protein family HMM PF05364; match to protein family HMM PF07487 YP_002045057.1 identified by match to protein family HMM PF02796 YP_002045058.1 identified by match to protein family HMM PF01610 YP_002045059.1 identified by match to protein family HMM PF01433; match to protein family HMM TIGR02414 YP_002045060.1 'catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors' YP_002045061.1 identified by match to protein family HMM PF07126 YP_002045062.1 identified by match to protein family HMM PF00111; match to protein family HMM PF03473; match to protein family HMM PF03476 YP_002045063.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_002045064.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_002045065.1 identified by match to protein family HMM PF04403; match to protein family HMM TIGR00155 YP_002045066.1 identified by match to protein family HMM PF02470 YP_002045067.1 identified by match to protein family HMM PF03886 YP_002045068.1 identified by glimmer; putative YP_002045069.1 'catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP' YP_002045070.1 identified by match to protein family HMM PF05362 YP_002045071.1 identified by match to protein family HMM PF06303 YP_002045072.1 'OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d' YP_002045073.1 identified by match to protein family HMM PF03846; match to protein family HMM TIGR00623 YP_002045074.1 identified by match to protein family HMM PF04993; match to protein family HMM PF04994 YP_002045075.1 identified by match to protein family HMM PF05976; match to protein family HMM TIGR01666; match to protein family HMM TIGR01667 YP_002045076.1 identified by match to protein family HMM PF03733 YP_002045077.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand YP_002045078.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_002045080.1 identified by match to protein family HMM PF08755; match to protein family HMM TIGR02097 YP_002045082.1 identified by match to protein family HMM PF01161; match to protein family HMM TIGR00481 YP_002045083.1 identified by match to protein family HMM PF00165 YP_002045084.1 catalyzes the hydrolysis of acylphosphate YP_002045085.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs YP_002045086.1 identified by match to protein family HMM PF01027 YP_002045089.1 identified by match to protein family HMM PF00805 YP_002045091.1 identified by match to protein family HMM PF07824 YP_002045092.1 identified by match to protein family HMM PF05925 YP_002045094.1 identified by glimmer; putative YP_002045095.1 identified by match to protein family HMM PF03577 YP_002045096.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM TIGR01386 YP_002045097.1 identified by match to protein family HMM PF00576; match to protein family HMM TIGR02962 YP_002045098.1 identified by match to protein family HMM PF01613; match to protein family HMM TIGR02296 YP_002045099.1 identified by match to protein family HMM PF03241; match to protein family HMM TIGR02310 YP_002045100.1 identified by match to protein family HMM PF01047; match to protein family HMM TIGR02337 YP_002045101.1 identified by match to protein family HMM PF01557; match to protein family HMM TIGR02303; match to protein family HMM TIGR02305 YP_002045102.1 identified by match to protein family HMM PF00171; match to protein family HMM TIGR02299 YP_002045103.1 identified by match to protein family HMM PF02900; match to protein family HMM TIGR02298 YP_002045104.1 identified by match to protein family HMM PF02962 YP_002045105.1 identified by match to protein family HMM PF01689; match to protein family HMM TIGR02312 YP_002045106.1 identified by match to protein family HMM PF03328; match to protein family HMM TIGR02311 YP_002045107.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR02332 YP_002045108.1 identified by match to protein family HMM PF00165; match to protein family HMM PF02311; match to protein family HMM TIGR02297 YP_002045109.1 identified by match to protein family HMM PF00753 YP_002045111.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA YP_002045112.1 'functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock' YP_002045114.1 identified by match to protein family HMM PF02683 YP_002045115.1 identified by match to protein family HMM PF01323 YP_002045116.1 identified by match to protein family HMM PF00578; match to protein family HMM PF08534 YP_002045117.1 identified by match to protein family HMM PF00328 YP_002045119.1 stationary phase protein that binds TrpR repressor YP_002045121.1 identified by match to protein family HMM PF00440; match to protein family HMM PF08362 YP_002045122.1 identified by match to protein family HMM PF07007 YP_002045123.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein YP_002045124.1 identified by match to protein family HMM PF00474; match to protein family HMM TIGR00813; match to protein family HMM TIGR02121 YP_002045125.1 identified by match to protein family HMM PF01380; match to protein family HMM PF01418 YP_002045126.1 identified by match to protein family HMM PF00474; match to protein family HMM TIGR00813 YP_002045127.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_002045128.1 identified by match to protein family HMM PF01344; match to protein family HMM PF07646; match to protein family HMM TIGR03547 YP_002045129.1 identified by match to protein family HMM PF06178 YP_002045130.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690 YP_002045131.1 identified by match to protein family HMM PF01408; match to protein family HMM PF02894 YP_002045132.1 identified by glimmer; putative YP_002045133.1 identified by match to protein family HMM PF02826 YP_002045134.1 identified by match to protein family HMM PF02811 YP_002045135.1 identified by match to protein family HMM PF06192 YP_002045136.1 identified by match to protein family HMM PF06496 YP_002045137.1 identified by match to protein family HMM PF03783 YP_002045138.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_002045139.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_002045140.1 activates the csgBA and csgDEFG operons involved in biofilm formation YP_002045141.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface YP_002045142.1 identified by match to protein family HMM PF07012 YP_002045143.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers YP_002045145.1 identified by match to protein family HMM PF01661 YP_002045146.2 identified by match to protein family HMM PF00614 YP_002045147.1 required for the transfer of succinyl residues to the glucan backbone YP_002045148.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_002045149.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_002045150.1 identified by match to protein family HMM PF07119 YP_002045152.1 Confers resistance to fosfomycin and deoxycholate YP_002045153.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_002045154.1 identified by match to protein family HMM PF00581 YP_002045155.1 identified by match to protein family HMM PF04264 YP_002045156.1 identified by match to protein family HMM PF01292 YP_002045159.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids YP_002045160.1 'BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing' YP_002045161.1 identified by match to protein family HMM PF06183 YP_002045162.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_002045163.1 identified by match to protein family HMM PF07273 YP_002045164.1 cofactor involved in the reduction of disulfides YP_002045165.1 Confers resistance to norfloxacin and enoxacin YP_002045166.1 identified by match to protein family HMM PF00583 YP_002045167.1 identified by match to protein family HMM PF04337 YP_002045168.1 identified by match to protein family HMM PF01408; match to protein family HMM PF02894 YP_002045169.1 identified by match to protein family HMM PF03023; match to protein family HMM TIGR01695 YP_002045170.1 identified by match to protein family HMM PF05130 YP_002045171.1 regulates the flagellar specific sigma28 transcription factor YP_002045172.1 required for the assembly of the flagellar basal body P-ring YP_002045173.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_002045174.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_002045175.1 'acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production' YP_002045176.1 the hook connects flagellar basal body to the flagellar filament YP_002045177.1 'FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod' YP_002045178.1 makes up the distal portion of the flagellar basal body rod YP_002045179.1 'part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod' YP_002045180.1 'part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum' YP_002045181.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_002045182.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_002045183.1 'with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes' YP_002045184.1 'bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase' YP_002045185.1 'catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA' YP_002045188.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002045189.1 identified by match to protein family HMM PF02620 YP_002045190.1 identified by glimmer; putative YP_002045191.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_002045192.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_002045193.1 identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128 YP_002045194.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002045195.1 carries the fatty acid chain in fatty acid biosynthesis YP_002045196.1 'FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP' YP_002045197.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_002045198.1 identified by match to protein family HMM PF02618; match to protein family HMM TIGR00247 YP_002045199.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_002045200.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_002045201.1 identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010 YP_002045202.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002045203.1 identified by match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783 YP_002045204.1 identified by match to protein family HMM PF01230 YP_002045205.1 identified by match to protein family HMM PF07233 YP_002045206.1 identified by match to protein family HMM TIGR02722 YP_002045207.1 catalyzes the phosphorylation of thiamine to thiamine phosphate YP_002045208.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_002045209.1 identified by match to protein family HMM PF05728 YP_002045210.1 identified by match to protein family HMM PF00070; match to protein family HMM PF01266; match to protein family HMM PF07992 YP_002045211.1 identified by match to protein family HMM PF05433 YP_002045212.1 identified by match to protein family HMM PF00440 YP_002045213.1 identified by match to protein family HMM PF07338 YP_002045214.1 identified by match to protein family HMM PF01476; match to protein family HMM PF03734 YP_002045215.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580 YP_002045216.1 identified by glimmer; putative YP_002045217.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_002045218.1 'outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone' YP_002045219.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_002045220.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine YP_002045221.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_002045222.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate YP_002045223.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_002045224.1 identified by glimmer; putative YP_002045225.1 translocated by the type III secretion system SPI-2; required for the formation of lysosomal glycoprotein structures (Sifs); required for maintenance of membrane in the Salmonella-containing vacuole; a cysteine residue with CAAX motif is modified by isoprenoid addition of protein geranylgeranyl transferase I; also modified by S-acylation YP_002045227.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component YP_002045228.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_002045229.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_002045230.1 identified by match to protein family HMM PF07719 YP_002045231.1 identified by match to protein family HMM PF08007 YP_002045232.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF08918 YP_002045233.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress YP_002045234.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_002045235.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_002045236.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_002045237.1 identified by match to protein family HMM PF00293 YP_002045239.2 identified by match to protein family HMM PF00849; match to protein family HMM TIGR00093 YP_002045240.1 Converts isocitrate to alpha ketoglutarate YP_002045241.1 identified by match to protein family HMM PF01797 YP_002045244.1 identified by match to protein family HMM PF06183 YP_002045245.1 identified by match to protein family HMM PF00652 YP_002045247.1 identified by match to protein family HMM PF06316 YP_002045248.1 identified by glimmer; putative YP_002045249.1 PliC; periplasmic lysozyme inhibitor of c-type lysozyme YP_002045252.1 identified by match to protein family HMM PF00011 YP_002045254.1 identified by match to protein family HMM PF01292 YP_002045256.1 identified by glimmer; putative YP_002045257.1 identified by glimmer; putative YP_002045258.1 identified by match to protein family HMM PF00496 YP_002045259.1 identified by match to protein family HMM PF00528 YP_002045260.1 identified by match to protein family HMM PF00528 YP_002045261.1 identified by match to protein family HMM PF00005 YP_002045262.1 identified by match to protein family HMM PF00005 YP_002045263.1 identified by match to protein family HMM PF00924 YP_002045265.1 identified by match to protein family HMM PF09223 YP_002045266.2 streptomycin 3'-adenyltransferase YP_002045267.1 identified by match to protein family HMM PF00196 YP_002045268.1 identified by match to protein family HMM PF00376 YP_002045271.1 catalyzes the interconversion of chorismate to prephenate YP_002045272.1 identified by match to protein family HMM PF01810 YP_002045273.1 identified by glimmer; putative YP_002045274.1 identified by match to protein family HMM PF09313 YP_002045275.1 identified by match to protein family HMM PF08956 YP_002045278.1 identified by match to protein family HMM PF04226 YP_002045280.1 identified by match to protein family HMM PF03891 YP_002045282.1 identified by match to protein family HMM PF04343 YP_002045283.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00896 YP_002045284.1 identified by match to protein family HMM PF04284 YP_002045287.1 identified by match to protein family HMM PF04073 YP_002045288.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254 YP_002045289.1 identified by match to protein family HMM PF04285 YP_002045290.1 identified by glimmer; putative YP_002045291.1 identified by match to protein family HMM PF06798; match to protein family HMM PF08298 YP_002045292.1 identified by match to protein family HMM PF06629 YP_002045294.1 identified by match to protein family HMM PF00248 YP_002045295.1 identified by match to protein family HMM PF01263 YP_002045296.1 identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534 YP_002045297.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_002045298.1 identified by match to protein family HMM PF07023 YP_002045299.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide YP_002045300.2 converts asparagine to aspartate and ammonia YP_002045301.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane YP_002045302.1 identified by match to protein family HMM PF00881 YP_002045303.1 catalyzes the formation of selenophosphate from selenide and ATP YP_002045304.1 decatenates replicating daughter chromosomes YP_002045305.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_002045306.1 identified by match to protein family HMM PF07383 YP_002045307.1 identified by match to protein family HMM PF00293 YP_002045308.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_002045309.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate YP_002045310.1 identified by match to protein family HMM PF04958; match to protein family HMM TIGR03243; match to protein family HMM TIGR03244 YP_002045311.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH YP_002045312.1 'catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation' YP_002045313.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_002045315.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP YP_002045316.1 3' incision activity; acts with UvrC YP_002045317.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002045318.1 identified by glimmer; putative YP_002045319.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein YP_002045320.1 'catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake' YP_002045321.1 'catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake' YP_002045322.1 'catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake' YP_002045323.1 represses the celABCDF-ydjC operon involved in carbon uptake YP_002045324.1 identified by match to protein family HMM PF02056 YP_002045325.1 identified by match to protein family HMM PF04794 YP_002045326.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide YP_002045328.1 identified by match to protein family HMM PF00375 YP_002045329.1 identified by match to protein family HMM PF04307 YP_002045330.1 'YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate' YP_002045332.1 identified by match to protein family HMM PF01636; match to protein family HMM PF03881 YP_002045334.1 identified by match to protein family HMM PF00294; match to protein family HMM TIGR03168 YP_002045335.1 identified by match to protein family HMM PF04338 YP_002045338.1 identified by match to protein family HMM PF01223 YP_002045340.1 'catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA' YP_002045341.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_002045342.1 identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001 YP_002045343.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_002045344.1 'catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily' YP_002045345.1 'catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily' YP_002045346.1 'This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control' YP_002045347.1 with BtuD and BtuF transports vitamin B12 into the cell YP_002045348.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane YP_002045349.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell YP_002045350.1 identified by match to protein family HMM PF00877 YP_002045351.1 identified by match to protein family HMM PF02696 YP_002045353.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_002045354.1 identified by match to protein family HMM PF03618 YP_002045355.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002045356.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids YP_002045358.1 identified by match to protein family HMM PF01266; match to protein family HMM PF01494; match to protein family HMM PF03486 YP_002045359.1 May play a role in a redox process YP_002045360.1 'YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain' YP_002045361.1 identified by glimmer; putative YP_002045362.1 identified by match to protein family HMM PF00165; match to protein family HMM PF07883 YP_002045363.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain YP_002045364.1 identified by match to protein family HMM PF01144 YP_002045365.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_002045366.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate YP_002045367.1 identified by match to protein family HMM PF07690 YP_002045368.1 identified by match to protein family HMM PF07690 YP_002045369.1 identified by match to protein family HMM PF08965 YP_002045370.1 'YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function' YP_002045371.1 identified by match to protein family HMM PF01565; match to protein family HMM PF02913 YP_002045372.1 identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369 YP_002045373.1 identified by match to protein family HMM PF00375 YP_002045374.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein YP_002045375.1 with SufCD activates cysteine desulfurase SufS YP_002045376.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE YP_002045377.1 with SufBC activates cysteine desulfurase SufS YP_002045378.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine YP_002045379.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine YP_002045380.1 identified by match to protein family HMM PF01476; match to protein family HMM PF03734 YP_002045381.1 identified by match to protein family HMM PF04728 YP_002045382.1 identified by glimmer; putative YP_002045383.1 identified by match to protein family HMM PF04728 YP_002045384.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002045385.1 identified by match to protein family HMM PF00324 YP_002045386.1 identified by match to protein family HMM PF07090 YP_002045387.1 identified by match to protein family HMM PF00294; match to protein family HMM PF08220; match to protein family HMM PF08543 YP_002045388.1 identified by match to protein family HMM PF01568; match to protein family HMM PF04879 YP_002045389.1 identified by match to protein family HMM PF03916 YP_002045390.1 identified by match to protein family HMM PF00037; match to protein family HMM TIGR01409 YP_002045391.1 identified by match to protein family HMM PF00512; match to protein family HMM PF02518 YP_002045392.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00196; match to protein family HMM PF08281 YP_002045394.1 identified by match to protein family HMM PF04463; match to protein family HMM PF08349 YP_002045395.1 identified by match to protein family HMM PF00376 YP_002045396.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00196 YP_002045397.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518 YP_002045398.1 identified by match to protein family HMM PF00263; match to protein family HMM PF03958; match to protein family HMM TIGR02516 YP_002045399.1 identified by match to protein family HMM TIGR02500 YP_002045400.1 identified by match to protein family HMM TIGR02501 YP_002045401.1 identified by match to protein family HMM PF03433 YP_002045402.1 identified by match to protein family HMM PF07719; match to protein family HMM PF07720; match to protein family HMM TIGR02552 YP_002045403.1 identified by match to protein family HMM PF04888 YP_002045406.1 identified by match to protein family HMM TIGR02552 YP_002045409.1 identified by match to protein family HMM PF09392; match to protein family HMM TIGR02105 YP_002045410.1 identified by match to protein family HMM TIGR02498 YP_002045411.1 identified by match to protein family HMM PF09525; match to protein family HMM TIGR02497 YP_002045412.1 identified by match to protein family HMM PF01514; match to protein family HMM TIGR02544 YP_002045414.1 identified by match to protein family HMM TIGR02499 YP_002045415.1 identified by match to protein family HMM PF07018; match to protein family HMM TIGR02511 YP_002045417.1 with SsaC forms part of a protein export system across the inner and outer cell membranes; part of the Salmonella pathogenicity island 2; part of the type III secretion system YP_002045418.1 identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026; match to protein family HMM TIGR02546 YP_002045421.1 identified by match to protein family HMM PF01052; match to protein family HMM TIGR02551 YP_002045422.1 part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response YP_002045424.1 identified by match to protein family HMM PF01311; match to protein family HMM TIGR01401 YP_002045425.1 'member of a type III secretion system which is part of a pathogenicity island in Salmonella, Yersinia and pathogenic Escherichia coli' YP_002045426.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_002045427.1 'catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine' YP_002045428.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge YP_002045429.1 uncharacterized member of the major facilitator superfamily (MFS) YP_002045430.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002045431.1 'binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers' YP_002045434.1 identified by match to protein family HMM PF00665 YP_002045435.1 identified by match to protein family HMM PF01526 YP_002045436.1 identified by match to protein family HMM PF00239 YP_002045437.1 identified by match to protein family HMM PF00665 YP_002045438.1 identified by match to protein family HMM PF01636 YP_002045439.1 identified by match to protein family HMM PF04655 YP_002045440.1 identified by match to protein family HMM PF00565 YP_002045441.1 identified by glimmer; putative YP_002045442.1 identified by glimmer; putative YP_002045443.1 identified by match to protein family HMM PF01131; match to protein family HMM PF01751 YP_002045445.1 identified by match to protein family HMM PF00665 YP_002045447.1 identified by match to protein family HMM PF00239; match to protein family HMM PF02796 YP_002045448.1 identified by match to protein family HMM PF00144 YP_002045449.1 identified by match to protein family HMM PF01695 YP_002045450.1 identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496 YP_002045451.1 identified by match to protein family HMM PF00893 YP_002045452.1 identified by match to protein family HMM PF00665 YP_002045453.1 identified by match to protein family HMM PF00004 YP_002045455.1 identified by match to protein family HMM PF00589 YP_002045456.1 identified by glimmer; putative YP_002045457.1 identified by glimmer; putative YP_002045459.1 identified by glimmer; putative YP_002045460.1 identified by match to protein family HMM PF00270; match to protein family HMM PF04851 YP_002045462.1 identified by match to protein family HMM PF07916 YP_002045463.1 identified by glimmer; putative YP_002045464.1 identified by glimmer; putative YP_002045466.1 TraN; TrhN; involved in stabilizing mating pairs during plasmid conjugation; F plasmid TraN appears to recognize OmpA in the recipient cell YP_002045467.1 identified by match to protein family HMM PF03090; match to protein family HMM PF08708 YP_002045468.1 identified by match to protein family HMM PF00589 YP_002045469.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals YP_002045470.1 identified by match to protein family HMM PF00877 YP_002045471.1 identified by match to protein family HMM PF00462; match to protein family HMM TIGR00365 YP_002045472.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_002045473.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione YP_002045474.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide YP_002045475.1 identified by match to protein family HMM PF00440 YP_002045477.1 identified by match to protein family HMM PF00248 YP_002045478.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water YP_002045479.1 identified by match to protein family HMM PF04632 YP_002045480.1 identified by match to protein family HMM PF00529 YP_002045481.1 identified by match to protein family HMM PF07869 YP_002045482.1 Transcription regulator that can both activate or repress expression YP_002045483.1 identified by match to protein family HMM PF05433 YP_002045484.1 'catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling' YP_002045485.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme YP_002045486.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_002045487.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_002045488.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_002045489.1 identified by match to protein family HMM PF00043; match to protein family HMM PF02798 YP_002045490.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation YP_002045491.1 'DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines' YP_002045492.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_002045493.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_002045494.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_002045495.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_002045496.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_002045497.1 identified by match to protein family HMM PF02508; match to protein family HMM TIGR01943 YP_002045499.1 'YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes' YP_002045500.1 identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894 YP_002045501.1 catalyzes the formation of inosine from adenosine YP_002045502.1 identified by match to protein family HMM PF06097 YP_002045503.1 identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218 YP_002045504.1 identified by match to protein family HMM PF05681; match to protein family HMM PF05683; match to protein family HMM TIGR00722; match to protein family HMM TIGR00723 YP_002045505.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_002045506.1 binds to DNA replication terminator sequences to prevent passage of replication forks YP_002045507.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518 YP_002045508.1 identified by match to protein family HMM PF01979; match to protein family HMM PF07969 YP_002045509.1 identified by match to protein family HMM PF00267 YP_002045511.1 response regulator in two-component regulatory system with RstB YP_002045512.1 identified by match to protein family HMM PF06942 YP_002045513.1 identified by match to protein family HMM PF00324; match to protein family HMM TIGR00905 YP_002045514.1 identified by match to protein family HMM PF07338 YP_002045515.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_002045516.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_002045517.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes YP_002045519.1 'with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS' YP_002045520.1 'with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS' YP_002045521.1 identified by match to protein family HMM PF00089 YP_002045522.1 identified by glimmer; putative YP_002045523.1 required for growth and survival under moderately acid conditions YP_002045524.1 identified by match to protein family HMM PF07690 YP_002045525.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002045526.1 identified by match to protein family HMM PF00480 YP_002045527.1 'DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium' YP_002045528.1 identified by match to protein family HMM PF00654 YP_002045529.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00571; match to protein family HMM TIGR01186 YP_002045530.1 identified by match to protein family HMM PF00528 YP_002045531.1 identified by match to protein family HMM PF04069 YP_002045532.1 identified by match to protein family HMM PF00528 YP_002045533.1 'binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane' YP_002045534.1 identified by match to protein family HMM PF04976 YP_002045535.1 identified by match to protein family HMM PF00037; match to protein family HMM TIGR02951 YP_002045536.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR02166 YP_002045537.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR02166 YP_002045538.1 identified by match to protein family HMM PF06649 YP_002045539.1 identified by match to protein family HMM PF06788 YP_002045540.1 identified by match to protein family HMM PF00583 YP_002045541.1 identified by match to protein family HMM PF06932 YP_002045542.1 identified by match to protein family HMM PF02694 YP_002045543.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746 YP_002045544.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240 YP_002045545.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883 YP_002045547.1 identified by match to protein family HMM PF01232; match to protein family HMM PF08125 YP_002045548.1 identified by match to protein family HMM TIGR03318 YP_002045549.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729 YP_002045550.1 'NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine' YP_002045551.1 identified by match to protein family HMM PF01432 YP_002045553.1 identified by match to protein family HMM PF02464; match to protein family HMM TIGR00199 YP_002045554.1 identified by match to protein family HMM PF04076; match to protein family HMM TIGR00156 YP_002045556.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters YP_002045557.1 identified by match to protein family HMM PF00892 YP_002045559.1 'transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF' YP_002045560.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes YP_002045561.1 'protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function' YP_002045562.1 identified by match to protein family HMM PF07690 YP_002045563.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002045564.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase YP_002045565.1 catalyzes the formation of glutamate from glutamine YP_002045568.1 identified by match to protein family HMM PF00267 YP_002045569.1 identified by match to protein family HMM PF01155; match to protein family HMM TIGR00100 YP_002045571.1 identified by match to protein family HMM PF00301; match to protein family HMM PF04809 YP_002045572.1 identified by match to protein family HMM PF07449 YP_002045573.1 identified by match to protein family HMM PF01455; match to protein family HMM TIGR00074 YP_002045574.1 identified by match to protein family HMM PF01750; match to protein family HMM TIGR00072; match to protein family HMM TIGR00140 YP_002045575.1 identified by match to protein family HMM PF01292; match to protein family HMM TIGR02125 YP_002045576.1 identified by match to protein family HMM PF00374 YP_002045577.1 identified by match to protein family HMM PF01058; match to protein family HMM PF08425; match to protein family HMM TIGR00391 YP_002045578.1 identified by match to protein family HMM PF02275 YP_002045579.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729 YP_002045580.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240 YP_002045581.1 identified by match to protein family HMM PF07690 YP_002045583.1 identified by match to protein family HMM PF07690 YP_002045584.1 identified by match to protein family HMM PF01494 YP_002045585.1 identified by match to protein family HMM PF01047 YP_002045587.1 identified by match to protein family HMM PF01042 YP_002045588.1 identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385 YP_002045589.1 identified by match to protein family HMM PF02604 YP_002045590.1 identified by match to protein family HMM PF07377 YP_002045592.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002045593.1 identified by match to protein family HMM PF03060 YP_002045594.1 identified by glimmer; putative YP_002045595.1 identified by glimmer; putative YP_002045596.1 identified by match to protein family HMM PF00532 YP_002045597.1 identified by match to protein family HMM PF03553; match to protein family HMM TIGR00931 YP_002045598.1 identified by match to protein family HMM PF00155 YP_002045599.1 identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02100 YP_002045600.1 identified by match to protein family HMM PF00128; match to protein family HMM TIGR02401 YP_002045601.1 identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02402 YP_002045602.1 identified by match to protein family HMM PF06884 YP_002045604.1 identified by match to protein family HMM PF02566; match to protein family HMM TIGR03562 YP_002045606.1 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase YP_002045607.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_002045608.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs YP_002045609.1 'nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase' YP_002045610.1 nitrate-inducible; identified by match to protein family HMM PF00037; match to protein family HMM PF09163; match to protein family HMM TIGR01582 YP_002045611.1 identified by match to protein family HMM PF00892 YP_002045612.1 identified by match to protein family HMM PF00267 YP_002045613.1 identified by match to protein family HMM PF04828 YP_002045614.1 identified by match to protein family HMM PF07690 YP_002045615.1 identified by match to protein family HMM PF00440 YP_002045616.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00886 YP_002045617.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01580 YP_002045618.1 identified by match to protein family HMM TIGR01660 YP_002045619.1 identified by match to protein family HMM PF02613; match to protein family HMM TIGR00684 YP_002045620.1 identified by match to protein family HMM PF02665; match to protein family HMM TIGR00351 YP_002045621.1 identified by match to protein family HMM PF02567; match to protein family HMM TIGR00654 YP_002045622.1 identified by match to protein family HMM PF00797 YP_002045623.1 identified by glimmer; putative YP_002045625.1 identified by match to protein family HMM PF00324 YP_002045626.1 identified by match to protein family HMM PF06004 YP_002045628.1 identified by match to protein family HMM PF00593; match to protein family HMM PF07715 YP_002045629.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729 YP_002045630.1 identified by glimmer; putative YP_002045631.1 identified by match to protein family HMM PF00107 YP_002045632.1 identified by match to protein family HMM PF00583 YP_002045633.1 identified by match to protein family HMM PF04657 YP_002045636.1 identified by match to protein family HMM PF07520 YP_002045639.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_002045640.1 identified by match to protein family HMM PF00155; match to protein family HMM PF00392 YP_002045641.1 identified by match to protein family HMM PF01427 YP_002045642.1 translocated by the type III secretion system SPI-2; localizes to Sifs in infected cells and specifically to Salmonella-containing vacuoles YP_002045644.1 identified by match to protein family HMM PF01136 YP_002045645.1 identified by match to protein family HMM PF01381; match to protein family HMM PF07883 YP_002045647.1 with TehA confers resistance to tellurite YP_002045648.1 identified by match to protein family HMM PF03595; match to protein family HMM TIGR00816 YP_002045650.1 identified by match to protein family HMM PF00583 YP_002045651.1 identified by match to protein family HMM PF01546; match to protein family HMM PF05343 YP_002045652.1 identified by match to protein family HMM PF02302 YP_002045653.1 identified by match to protein family HMM PF03611; match to protein family HMM TIGR00827 YP_002045654.1 identified by match to protein family HMM PF03437; match to protein family HMM TIGR00259 YP_002045655.1 identified by match to protein family HMM PF00359 YP_002045656.1 identified by match to protein family HMM PF00834 YP_002045657.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220 YP_002045658.1 identified by match to protein family HMM PF00583 YP_002045659.1 identified by match to protein family HMM PF01070; match to protein family HMM PF01180 YP_002045660.1 identified by match to protein family HMM PF04264 YP_002045661.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans YP_002045662.1 identified by match to protein family HMM PF00135 YP_002045663.1 identified by match to protein family HMM PF07063 YP_002045664.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002045665.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203 YP_002045666.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; match to protein family HMM TIGR02818 YP_002045667.1 identified by match to protein family HMM PF02583 YP_002045668.1 identified by glimmer; putative YP_002045669.1 identified by glimmer; putative YP_002045672.1 identified by match to protein family HMM PF06961 YP_002045673.1 identified by match to protein family HMM PF00497 YP_002045674.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_002045675.1 identified by match to protein family HMM PF00005 YP_002045676.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_002045678.1 identified by match to protein family HMM PF08241; match to protein family HMM PF08242 YP_002045679.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm YP_002045680.1 identified by match to protein family HMM PF02698 YP_002045681.1 'involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain' YP_002045682.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_002045683.1 identified by match to protein family HMM PF04828 YP_002045684.1 identified by match to protein family HMM PF07027 YP_002045687.1 identified by match to protein family HMM PF00389; match to protein family HMM PF02826 YP_002045688.1 identified by match to protein family HMM PF03724 YP_002045691.1 identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176 YP_002045692.1 identified by glimmer; putative YP_002045693.1 identified by match to protein family HMM PF00582 YP_002045694.1 identified by match to protein family HMM PF00893 YP_002045695.1 identified by glimmer; putative YP_002045696.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_002045697.1 'exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA' YP_002045698.1 identified by match to protein family HMM PF01544 YP_002045699.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672 YP_002045700.1 identified by glimmer; putative YP_002045701.1 identified by match to protein family HMM PF01713 YP_002045702.1 identified by match to protein family HMM PF01035; match to protein family HMM PF02870; match to protein family HMM TIGR00589 YP_002045703.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_002045704.1 with UspC and UspD is involved in resistance to UV irradiation YP_002045706.1 identified by match to protein family HMM PF00924 YP_002045707.1 identified by match to protein family HMM PF01381; match to protein family HMM PF07883 YP_002045708.1 identified by match to protein family HMM PF03483 YP_002045714.1 identified by match to protein family HMM PF01609 YP_002045716.2 identified by match to protein family HMM PF06004 YP_002045717.1 identified by match to protein family HMM PF00440 YP_002045718.1 identified by match to protein family HMM PF00106 YP_002045719.1 identified by match to protein family HMM PF00248 YP_002045720.1 identified by glimmer; putative YP_002045721.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002045722.1 identified by match to protein family HMM PF05368 YP_002045723.1 identified by match to protein family HMM PF00496 YP_002045724.1 identified by match to protein family HMM PF00246 YP_002045725.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746 YP_002045726.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_002045727.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids YP_002045728.1 identified by match to protein family HMM PF05128; match to protein family HMM TIGR01620 YP_002045729.1 identified by match to protein family HMM PF04317 YP_002045730.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide YP_002045731.1 identified by match to protein family HMM PF09584; match to protein family HMM TIGR02979 YP_002045732.1 'with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock' YP_002045733.1 'acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding' YP_002045734.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF YP_002045735.1 'transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor' YP_002045736.1 identified by match to protein family HMM PF00496 YP_002045737.1 identified by match to protein family HMM PF00528 YP_002045738.1 identified by match to protein family HMM PF00528 YP_002045739.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727 YP_002045740.1 identified by match to protein family HMM PF00005 YP_002045743.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_002045744.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction YP_002045745.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP YP_002045747.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279 YP_002045749.1 involved in start site selection during the initiation of translation YP_002045750.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_002045751.1 identified by glimmer; putative YP_002045752.1 identified by match to protein family HMM PF07719 YP_002045753.1 identified by match to protein family HMM PF06305 YP_002045754.1 identified by match to protein family HMM PF01569 YP_002045755.2 'catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate' YP_002045756.1 Catalyzes the conversion of citrate to isocitrate YP_002045759.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_002045760.1 identified by glimmer; putative YP_002045761.1 'catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity' YP_002045763.1 SohB; periplasmic protein; member of the peptidase S49 family YP_002045764.1 identified by match to protein family HMM PF00106; match to protein family HMM PF08659 YP_002045765.1 'catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide' YP_002045766.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA YP_002045767.1 identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057 YP_002045768.1 identified by match to protein family HMM PF02811 YP_002045769.1 'with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine' YP_002045770.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis YP_002045771.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_002045772.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_002045773.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_002045775.1 identified by match to protein family HMM PF05974 YP_002045776.1 identified by match to protein family HMM PF05974 YP_002045777.1 identified by match to protein family HMM PF05067 YP_002045778.1 receptor for colicin S4 YP_002045779.1 identified by match to protein family HMM PF03692 YP_002045780.1 identified by match to protein family HMM PF06790 YP_002045781.1 Involved in cell division; probably involved in intracellular septation YP_002045782.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins YP_002045783.1 'membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins' YP_002045784.1 'unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity' YP_002045786.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_002045787.1 identified by match to protein family HMM PF00520; match to protein family HMM PF07885 YP_002045788.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727 YP_002045789.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727 YP_002045790.1 identified by match to protein family HMM PF00528 YP_002045791.1 identified by match to protein family HMM PF00528 YP_002045792.1 identified by match to protein family HMM PF00496 YP_002045793.1 identified by match to protein family HMM PF01914; match to protein family HMM TIGR00427 YP_002045794.1 identified by match to protein family HMM PF00171; match to protein family HMM PF00465 YP_002045795.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_002045796.1 identified by match to protein family HMM PF00816 YP_002045797.1 'together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose' YP_002045798.1 identified by match to protein family HMM PF00072 YP_002045799.1 identified by match to protein family HMM PF01734 YP_002045800.1 identified by match to protein family HMM PF02810 YP_002045801.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_002045802.1 identified by match to protein family HMM PF08238 YP_002045804.1 identified by match to protein family HMM PF02665; match to protein family HMM TIGR00351 YP_002045805.1 identified by match to protein family HMM PF02613; match to protein family HMM TIGR00684 YP_002045806.1 identified by match to protein family HMM TIGR01660 YP_002045807.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01580 YP_002045808.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00886 YP_002045809.1 identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF07730 YP_002045810.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase YP_002045812.1 identified by match to protein family HMM PF02635 YP_002045813.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions YP_002045814.1 identified by match to protein family HMM PF01699; match to protein family HMM TIGR00846 YP_002045815.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_002045817.1 identified by match to protein family HMM PF04247 YP_002045818.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB YP_002045819.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_002045820.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_002045821.1 identified by glimmer; putative YP_002045822.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_002045823.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_002045824.1 identified by glimmer; putative YP_002045825.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002045826.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_002045827.1 'YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function' YP_002045828.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_002045829.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_002045832.2 identified by match to protein family HMM PF01058; match to protein family HMM PF08425; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409 YP_002045833.1 involved in hydrogen cycling during fermentative growth YP_002045834.1 identified by match to protein family HMM PF01292; match to protein family HMM TIGR02125 YP_002045835.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1) YP_002045836.1 involved in processing hydrogenase proteins HyaA and HyaB YP_002045837.1 identified by match to protein family HMM PF04809 YP_002045838.1 identified by match to protein family HMM PF01654 YP_002045839.1 identified by match to protein family HMM PF02322; match to protein family HMM TIGR00203 YP_002045840.1 identified by match to protein family HMM PF00208; match to protein family HMM PF02812 YP_002045842.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell YP_002045843.1 identified by match to protein family HMM PF04226 YP_002045844.1 identified by match to protein family HMM PF07238; match to protein family HMM PF07317 YP_002045845.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine YP_002045846.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_002045847.1 'catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA' YP_002045848.1 catalyzes the oxidative deamination of D-amino acids YP_002045849.1 identified by match to protein family HMM PF04293 YP_002045850.1 Multifunctional regulator of fatty acid metabolism YP_002045851.1 involved in regulation of intracellular pH under alkaline conditions YP_002045852.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_002045853.1 identified by match to protein family HMM PF09313 YP_002045854.1 identified by match to protein family HMM PF08178 YP_002045857.1 identified by match to protein family HMM PF03692 YP_002045858.1 identified by match to protein family HMM PF01557 YP_002045859.2 identified by match to protein family HMM PF05166 YP_002045860.1 blocks the formation of polar Z-ring septums YP_002045861.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums YP_002045862.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_002045863.1 identified by match to protein family HMM PF00570; match to protein family HMM PF01612; match to protein family HMM TIGR01388 YP_002045864.1 Activates fatty acids by binding to coenzyme A YP_002045866.1 identified by match to protein family HMM PF03843; match to protein family HMM TIGR00752 YP_002045867.1 identified by match to protein family HMM PF00814 YP_002045869.1 identified by match to protein family HMM PF01042 YP_002045870.1 identified by match to protein family HMM PF03701 YP_002045871.1 identified by match to protein family HMM PF00425; match to protein family HMM PF04715; match to protein family HMM TIGR00553 YP_002045872.1 identified by match to protein family HMM PF00293 YP_002045873.1 identified by match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720 YP_002045874.1 identified by match to protein family HMM PF00563 YP_002045875.1 identified by match to protein family HMM PF00571; match to protein family HMM PF03471; match to protein family HMM PF03741 YP_002045876.1 identified by match to protein family HMM PF03610; match to protein family HMM PF03830; match to protein family HMM TIGR00824; match to protein family HMM TIGR00854 YP_002045877.1 identified by match to protein family HMM PF03609; match to protein family HMM TIGR00822 YP_002045878.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel YP_002045879.1 identified by match to protein family HMM PF06173 YP_002045880.1 identified by match to protein family HMM PF02659 YP_002045881.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth YP_002045882.1 identified by match to protein family HMM PF00905; match to protein family HMM PF03717 YP_002045883.1 identified by match to protein family HMM PF00313 YP_002045888.1 identified by match to protein family HMM PF01614; match to protein family HMM PF09339 YP_002045889.1 putative metalloprotease YP_002045890.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_002045891.1 affects solute and DNA transport through an unknown mechanism YP_002045892.2 identified by match to protein family HMM PF01590 YP_002045893.1 identified by match to protein family HMM PF04403; match to protein family HMM TIGR00155 YP_002045894.1 identified by match to protein family HMM PF02470 YP_002045895.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA YP_002045896.1 identified by glimmer; putative YP_002045897.1 identified by match to protein family HMM PF07351 YP_002045898.1 identified by match to protein family HMM PF07358 YP_002045899.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins YP_002045900.1 identified by glimmer; putative YP_002045903.1 identified by match to protein family HMM PF05364; match to protein family HMM PF07487 YP_002045904.1 identified by glimmer; putative YP_002045905.1 identified by match to protein family HMM PF07166 YP_002045910.1 identified by glimmer; putative YP_002045912.1 identified by glimmer; putative YP_002045913.1 identified by glimmer; putative YP_002045914.1 identified by match to protein family HMM PF00892 YP_002045918.1 identified by match to protein family HMM PF01609 YP_002045919.1 identified by match to protein family HMM PF02413 YP_002045920.1 identified by match to protein family HMM PF07278 YP_002045925.1 identified by match to protein family HMM PF00589 YP_002045927.1 identified by match to protein family HMM PF05425 YP_002045928.1 identified by match to protein family HMM PF04234 YP_002045929.1 identified by match to protein family HMM PF06440 YP_002045930.1 identified by match to protein family HMM PF00795 YP_002045931.1 3'-5' exonuclease activity on single or double-strand DNA YP_002045932.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues YP_002045933.1 identified by match to protein family HMM PF04391 YP_002045934.1 secreted protein; unknown function YP_002045935.1 identified by match to protein family HMM PF07130 YP_002045936.1 'non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis' YP_002045937.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_002045938.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_002045939.1 'catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate' YP_002045940.1 'Represses the expression of the zwf, eda, glp and gap' YP_002045941.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002045942.1 'Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA' YP_002045943.1 identified by match to protein family HMM PF01476; match to protein family HMM PF01551; match to protein family HMM PF04225; match to protein family HMM PF08525 YP_002045944.1 involved in transport of zinc(II) with ZnuA and C YP_002045945.1 involved in transport of zinc(II) with ZnuA and C YP_002045946.1 involved in transport of zinc(II) with ZnuA and C YP_002045947.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_002045948.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_002045950.1 identified by match to protein family HMM PF06520 YP_002045951.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_002045952.1 identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033 YP_002045953.1 converts dATP to dAMP and pyrophosphate YP_002045954.1 'catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes' YP_002045955.1 identified by match to protein family HMM PF00857 YP_002045956.1 identified by match to protein family HMM PF01904 YP_002045958.1 identified by match to protein family HMM PF08241; match to protein family HMM PF08242; match to protein family HMM TIGR00740 YP_002045959.1 identified by match to protein family HMM PF08003; match to protein family HMM PF08241; match to protein family HMM TIGR00452 YP_002045960.1 identified by match to protein family HMM PF03932 YP_002045961.1 identified by match to protein family HMM PF06185 YP_002045963.1 'catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase' YP_002045964.1 identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM TIGR03423 YP_002045965.1 identified by match to protein family HMM PF07470 YP_002045966.1 identified by match to protein family HMM PF06366 YP_002045967.1 membrane protein involved in the flagellar export apparatus YP_002045968.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_002045969.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation YP_002045970.1 'chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble' YP_002045971.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_002045972.1 methylates the MCP YP_002045973.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203 YP_002045974.1 identified by glimmer; putative YP_002045975.1 identified by match to protein family HMM PF01584 YP_002045976.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component YP_002045977.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_002045978.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_002045979.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems YP_002045980.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems YP_002045981.1 identified by glimmer; putative YP_002045982.1 'ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress' YP_002045983.1 identified by match to protein family HMM PF00982; match to protein family HMM TIGR02400 YP_002045984.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature YP_002045985.1 identified by match to protein family HMM PF01965 YP_002045986.1 identified by match to protein family HMM PF00210 YP_002045987.1 identified by match to protein family HMM PF02502 YP_002045989.1 cytoplasmic iron storage protein YP_002045991.1 identified by match to protein family HMM PF01490; match to protein family HMM PF03222; match to protein family HMM TIGR00837 YP_002045992.1 identified by match to protein family HMM PF02810; match to protein family HMM TIGR02292 YP_002045994.1 identified by match to protein family HMM PF00877 YP_002045996.1 identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560 YP_002045997.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_002045998.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system YP_002046001.1 regulates genes involved in cell division YP_002046002.1 identified by match to protein family HMM PF00005 YP_002046003.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_002046004.1 catalyzes the formation of pyruvate from D-cysteine YP_002046005.1 identified by match to protein family HMM PF00497 YP_002046006.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_002046008.1 'structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes' YP_002046009.1 identified by glimmer; putative YP_002046010.1 involved in flagellin assembly YP_002046011.1 flagellin specific chaperone YP_002046012.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family YP_002046013.1 'converts 1,4-alpha-D-glucans to maltodextrin' YP_002046015.2 identified by match to protein family HMM PF04143 YP_002046016.1 identified by match to protein family HMM PF01206 YP_002046018.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_002046020.1 'the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod' YP_002046021.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002046022.1 binds to and inhibits the function of flagella specific ATPase FliI YP_002046023.1 involved in type III protein export during flagellum assembly YP_002046024.1 rod/hook and filament chaperone YP_002046025.1 identified by match to protein family HMM PF02120 YP_002046026.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_002046027.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_002046028.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002046029.1 'with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus' YP_002046030.1 'FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus' YP_002046031.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_002046032.1 'FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus' YP_002046033.1 identified by glimmer; putative YP_002046034.1 identified by match to protein family HMM PF00196 YP_002046037.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate YP_002046038.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254 YP_002046039.1 identified by match to protein family HMM PF05661 YP_002046040.1 identified by match to protein family HMM PF00892 YP_002046041.1 identified by match to protein family HMM PF03852; match to protein family HMM TIGR00632 YP_002046042.1 identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675 YP_002046043.1 identified by match to protein family HMM PF01966 YP_002046045.1 identified by glimmer; putative YP_002046046.1 identified by match to protein family HMM PF00267 YP_002046047.1 identified by glimmer; putative YP_002046048.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_002046049.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_002046051.1 identified by match to protein family HMM PF06167 YP_002046053.1 identified by glimmer; putative YP_002046056.1 identified by match to protein family HMM PF07661; match to protein family HMM PF08238 YP_002046060.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_002046062.1 identified by match to protein family HMM PF07377 YP_002046063.1 identified by match to protein family HMM PF03734 YP_002046064.1 'catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole' YP_002046065.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_002046066.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP YP_002046067.1 'catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation' YP_002046068.1 with CbiNQ forms the ABC transporter for cobalt import YP_002046069.1 identified by match to protein family HMM PF02361; match to protein family HMM TIGR02454 YP_002046070.1 periplasmic cobalt binding component of the cobalt transport system YP_002046071.1 catalyzes the ATP-dependent transport of cobalt YP_002046072.1 catalyzes the formation of precorrin-3A from precorrin-2 YP_002046073.1 identified by match to protein family HMM PF06180 YP_002046074.1 'CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6' YP_002046075.1 identified by match to protein family HMM PF00590; match to protein family HMM TIGR01466 YP_002046076.1 catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3 YP_002046077.1 identified by match to protein family HMM PF00590; match to protein family HMM TIGR01465 YP_002046078.1 catalyzes the methylation of either C-15 or C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W; decarboxylating YP_002046079.1 catalyzes the methylation of C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W-a YP_002046080.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A YP_002046081.1 catalyzes the interconversion of cobalt-precorrin-8X and cobyrinic acid in the anaerobic biosynthesis of cobalamin YP_002046082.1 CobD; CbiB in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_002046083.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_002046084.1 identified by match to protein family HMM PF00165 YP_002046085.1 identified by match to protein family HMM PF00230; match to protein family HMM TIGR00861 YP_002046086.1 identified by match to protein family HMM PF00936 YP_002046087.1 identified by match to protein family HMM PF00936 YP_002046088.1 identified by match to protein family HMM PF02286 YP_002046089.1 identified by match to protein family HMM PF02288 YP_002046090.1 identified by match to protein family HMM PF02287 YP_002046091.1 identified by match to protein family HMM PF08841 YP_002046093.1 identified by match to protein family HMM PF00936 YP_002046094.1 identified by match to protein family HMM PF00936 YP_002046095.1 identified by match to protein family HMM PF06130 YP_002046097.1 identified by match to protein family HMM PF03319 YP_002046098.1 identified by match to protein family HMM PF01923; match to protein family HMM PF03928; match to protein family HMM TIGR00636 YP_002046099.1 identified by match to protein family HMM PF00171 YP_002046100.1 identified by match to protein family HMM PF00465 YP_002046101.1 identified by match to protein family HMM PF01512 YP_002046102.1 identified by match to protein family HMM PF00936 YP_002046103.1 identified by match to protein family HMM PF00936 YP_002046104.1 identified by match to protein family HMM TIGR02528 YP_002046105.1 'involved in coenzyme B(12)-dependent 1, 2-propanediol degradation; important for the synthesis of propionyl coenzyme A during growth on 1,2-propanediol' YP_002046106.1 identified by match to protein family HMM PF00288; match to protein family HMM PF08544 YP_002046107.1 identified by match to protein family HMM PF04363 YP_002046109.1 identified by match to protein family HMM PF06445 YP_002046110.1 'removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains' YP_002046111.1 identified by match to protein family HMM PF01292 YP_002046112.1 identified by match to protein family HMM PF00037 YP_002046113.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409 YP_002046115.1 identified by glimmer; putative YP_002046116.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_002046117.1 identified by match to protein family HMM PF00324 YP_002046118.1 identified by glimmer; putative YP_002046119.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002046120.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370 YP_002046121.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_002046122.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002046123.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_002046124.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_002046125.1 'with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide' YP_002046126.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_002046127.1 'catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase' YP_002046128.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_002046129.1 identified by match to protein family HMM PF02706 YP_002046130.1 identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026 YP_002046131.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_002046132.1 identified by match to protein family HMM PF02397; match to protein family HMM TIGR03022; match to protein family HMM TIGR03025 YP_002046133.1 identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880 YP_002046134.1 identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479 YP_002046135.1 identified by match to protein family HMM PF00535 YP_002046136.1 identified by match to protein family HMM PF00534 YP_002046137.1 identified by match to protein family HMM PF00535 YP_002046138.1 identified by match to protein family HMM PF01943 YP_002046139.1 identified by match to protein family HMM PF01370 YP_002046140.1 identified by match to protein family HMM PF01041 YP_002046141.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF07993; match to protein family HMM TIGR02622 YP_002046142.1 identified by match to protein family HMM PF00483; match to protein family HMM TIGR02623 YP_002046143.1 'catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose' YP_002046144.1 identified by match to protein family HMM PF00908; match to protein family HMM TIGR01221 YP_002046145.1 identified by match to protein family HMM PF00483; match to protein family HMM TIGR01207 YP_002046146.1 'with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose' YP_002046147.1 NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose YP_002046148.1 'together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose' YP_002046149.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid YP_002046150.1 identified by match to protein family HMM PF00534 YP_002046151.1 identified by match to protein family HMM PF04230 YP_002046152.1 identified by match to protein family HMM PF01943 YP_002046153.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid YP_002046154.1 identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880 YP_002046155.1 identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479 YP_002046156.1 identified by match to protein family HMM PF00534 YP_002046157.1 identified by match to protein family HMM PF00293 YP_002046158.1 identified by match to protein family HMM PF01370 YP_002046159.1 identified by match to protein family HMM PF01370; match to protein family HMM TIGR01472 YP_002046160.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit) YP_002046161.1 identified by match to protein family HMM PF00535 YP_002046162.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance YP_002046164.1 'acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium' YP_002046165.1 identified by match to protein family HMM PF00535 YP_002046166.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide) YP_002046167.1 'Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis' YP_002046168.1 identified by match to protein family HMM PF02563 YP_002046170.1 'YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs' YP_002046171.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_002046172.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_002046174.1 identified by match to protein family HMM PF00563; match to protein family HMM PF00989; match to protein family HMM PF00990; match to protein family HMM PF05231; match to protein family HMM PF08447; match to protein family HMM PF08448; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254 YP_002046175.1 'inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine' YP_002046178.1 'Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate' YP_002046179.1 'Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate' YP_002046180.1 'Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate' YP_002046181.1 identified by match to protein family HMM PF07690 YP_002046182.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518 YP_002046183.1 'response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport' YP_002046187.1 identified by match to protein family HMM PF01136 YP_002046193.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role YP_002046194.1 identified by match to protein family HMM PF03825; match to protein family HMM PF07690; match to protein family HMM TIGR00889 YP_002046195.1 identified by match to protein family HMM PF03747 YP_002046196.1 identified by match to protein family HMM PF00294 YP_002046197.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702 YP_002046198.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_002046199.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_002046200.1 identified by glimmer; putative YP_002046203.1 identified by match to protein family HMM PF00577 YP_002046204.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753 YP_002046205.1 identified by match to protein family HMM PF00419 YP_002046208.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_002046209.1 identified by match to protein family HMM PF06998 YP_002046210.1 identified by match to protein family HMM PF06998 YP_002046211.1 identified by match to protein family HMM PF07308 YP_002046212.1 unknown function; when overproduced it confers drug-resistance YP_002046213.1 identified by match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF06580; match to protein family HMM PF07694 YP_002046214.1 identified by match to protein family HMM PF00376 YP_002046215.1 identified by match to protein family HMM PF00528 YP_002046216.1 identified by match to protein family HMM PF00005 YP_002046217.1 identified by match to protein family HMM PF00528 YP_002046218.1 identified by match to protein family HMM PF04069 YP_002046219.1 identified by match to protein family HMM PF00933; match to protein family HMM PF01915 YP_002046220.1 'component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent' YP_002046221.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7 YP_002046222.1 identified by match to protein family HMM PF06930 YP_002046223.1 identified by match to protein family HMM PF09335 YP_002046224.1 identified by match to protein family HMM PF00106 YP_002046225.1 'may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride' YP_002046228.1 identified by match to protein family HMM PF01207 YP_002046229.1 catalyzes the formation of catechol from salicylate YP_002046230.1 identified by match to protein family HMM PF02798; match to protein family HMM TIGR01262 YP_002046231.1 identified by match to protein family HMM PF01557 YP_002046232.1 identified by match to protein family HMM PF07883; match to protein family HMM TIGR02272 YP_002046233.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690 YP_002046234.1 identified by match to protein family HMM PF03788 YP_002046235.1 identified by match to protein family HMM PF04172; match to protein family HMM TIGR00659 YP_002046236.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_002046237.1 identified by match to protein family HMM PF02698 YP_002046239.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_002046240.1 'catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines' YP_002046241.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex YP_002046242.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains YP_002046243.1 identified by match to protein family HMM PF00532 YP_002046244.1 negative regulator of the mglBAC operon for galactose utilization YP_002046245.1 identified by match to protein family HMM PF04171; match to protein family HMM PF04235 YP_002046246.1 'involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer' YP_002046247.1 identified by match to protein family HMM PF00756; match to protein family HMM TIGR02821 YP_002046248.1 identified by match to protein family HMM PF01381 YP_002046249.1 identified by match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720 YP_002046250.1 identified by match to protein family HMM PF00702; match to protein family HMM PF06888; match to protein family HMM PF08282; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488 YP_002046251.1 identified by match to protein family HMM PF07690 YP_002046252.1 'Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein' YP_002046253.1 identified by match to protein family HMM PF00324 YP_002046254.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002046256.1 identified by match to protein family HMM PF03601; match to protein family HMM TIGR00698 YP_002046257.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_002046258.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002046259.1 'converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers' YP_002046260.1 'phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr' YP_002046261.1 identified by glimmer; putative YP_002046262.1 identified by glimmer; putative YP_002046263.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00899 YP_002046266.1 'Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein' YP_002046267.2 identified by match to protein family HMM PF02492 YP_002046268.1 identified by match to protein family HMM PF01569 YP_002046269.1 'by similarity, Spr seems to have peptidase activity; involved in thermoresistance' YP_002046270.1 identified by match to protein family HMM PF00563 YP_002046271.1 identified by match to protein family HMM PF00496 YP_002046272.1 identified by match to protein family HMM PF00528 YP_002046273.1 identified by match to protein family HMM PF00528 YP_002046274.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352 YP_002046276.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance YP_002046277.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA YP_002046278.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04851 YP_002046279.1 'the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response' YP_002046281.1 identified by match to protein family HMM PF04245 YP_002046282.1 identified by match to protein family HMM PF07208 YP_002046283.1 identified by match to protein family HMM PF00884 YP_002046286.1 identified by glimmer; putative YP_002046287.2 identified by match to protein family HMM PF02413 YP_002046288.1 identified by match to protein family HMM PF02413 YP_002046290.1 identified by match to protein family HMM PF04586; match to protein family HMM TIGR01543 YP_002046291.1 identified by match to protein family HMM TIGR01594 YP_002046292.1 identified by match to protein family HMM PF07693 YP_002046293.1 identified by match to protein family HMM PF06914 YP_002046296.1 identified by glimmer; putative YP_002046297.1 identified by glimmer; putative YP_002046299.1 identified by match to protein family HMM PF09411 YP_002046300.1 identified by glimmer; putative YP_002046301.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes YP_002046302.1 identified by match to protein family HMM PF03918 YP_002046303.1 identified by match to protein family HMM PF00578; match to protein family HMM PF08534; match to protein family HMM TIGR00385 YP_002046304.1 identified by match to protein family HMM PF01578; match to protein family HMM TIGR00353 YP_002046305.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_002046306.1 identified by match to protein family HMM PF04995; match to protein family HMM TIGR03141 YP_002046307.1 identified by match to protein family HMM PF01578; match to protein family HMM TIGR01191 YP_002046308.1 identified by match to protein family HMM PF03379; match to protein family HMM TIGR01190 YP_002046309.1 ATP-binding protein; required for proper cytochrome c maturation YP_002046310.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone YP_002046311.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA YP_002046312.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA YP_002046313.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway YP_002046314.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_002046315.1 identified by match to protein family HMM PF03927 YP_002046316.1 identified by match to protein family HMM PF00037 YP_002046317.1 'serine protease inhibitor, inhibits trypsin and other proteases' YP_002046318.1 efflux pump for the antibacterial peptide microcin J25 YP_002046319.1 identified by match to protein family HMM PF03171 YP_002046320.1 identified by match to protein family HMM PF00165; match to protein family HMM PF01035; match to protein family HMM PF02805; match to protein family HMM PF02870; match to protein family HMM TIGR00589 YP_002046321.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway YP_002046322.1 allows for ions and hydrophilic solutes to cross the outer membrane YP_002046323.1 identified by match to protein family HMM PF01627; match to protein family HMM PF02518 YP_002046324.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF YP_002046325.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518; match to protein family HMM PF09456 YP_002046326.1 negatively supercoils closed circular double-stranded DNA YP_002046327.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746 YP_002046328.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690 YP_002046329.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729 YP_002046330.1 Involved in ubiquinone biosynthesis YP_002046331.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002046332.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_002046333.1 'plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases' YP_002046334.1 identified by match to protein family HMM PF07690 YP_002046335.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002046336.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic YP_002046337.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell YP_002046338.1 'anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor' YP_002046339.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters YP_002046340.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate YP_002046341.1 'similar to ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system' YP_002046343.1 identified by match to protein family HMM PF03328 YP_002046344.1 identified by match to protein family HMM PF07690 YP_002046345.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746 YP_002046346.1 identified by match to protein family HMM PF01614 YP_002046347.1 identified by match to protein family HMM PF00994; match to protein family HMM TIGR00177; match to protein family HMM TIGR00200 YP_002046348.1 identified by match to protein family HMM PF07437 YP_002046349.1 identified by match to protein family HMM PF00293 YP_002046350.1 identified by match to protein family HMM PF00300 YP_002046351.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose YP_002046352.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate YP_002046353.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains YP_002046354.1 identified by match to protein family HMM PF01522 YP_002046355.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A YP_002046356.1 identified by match to protein family HMM PF00893 YP_002046359.1 identified by match to protein family HMM PF00501; match to protein family HMM TIGR01923 YP_002046360.1 'catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate' YP_002046361.1 'catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA' YP_002046362.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA YP_002046363.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_002046364.1 identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543 YP_002046365.1 identified by match to protein family HMM PF05957 YP_002046366.1 identified by match to protein family HMM PF00583 YP_002046367.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_002046368.1 identified by match to protein family HMM PF00072; match to protein family HMM PF01584 YP_002046369.1 Catalyzes the transfer of electrons from NADH to quinone YP_002046370.1 Catalyzes the transfer of electrons from NADH to quinone YP_002046371.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_002046372.1 Catalyzes the transfer of electrons from NADH to quinone YP_002046373.1 Catalyzes the transfer of electrons from NADH to quinone YP_002046374.1 Catalyzes the transfer of electrons from NADH to quinone YP_002046375.1 Catalyzes the transfer of electrons from NADH to quinone YP_002046376.1 Catalyzes the transfer of electrons from NADH to quinone YP_002046377.1 'shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase' YP_002046378.1 Catalyzes the transfer of electrons from NADH to quinone YP_002046379.1 'NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms' YP_002046380.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_002046381.1 Catalyzes the transfer of electrons from NADH to quinone YP_002046383.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002046385.1 'broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor' YP_002046386.1 identified by match to protein family HMM PF01966 YP_002046387.1 identified by match to protein family HMM PF02080; match to protein family HMM PF03600; match to protein family HMM PF06808 YP_002046388.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549 YP_002046389.1 identified by match to protein family HMM PF03887 YP_002046390.1 identified by match to protein family HMM PF04217 YP_002046391.1 identified by glimmer; putative YP_002046392.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_002046393.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_002046394.1 identified by match to protein family HMM PF03606 YP_002046395.1 identified by match to protein family HMM PF02779; match to protein family HMM PF02780 YP_002046396.1 identified by match to protein family HMM PF00456 YP_002046397.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_002046398.1 identified by match to protein family HMM PF02302 YP_002046399.1 identified by match to protein family HMM PF00359 YP_002046400.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532 YP_002046401.1 identified by match to protein family HMM PF00293 YP_002046402.1 identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040 YP_002046403.1 identified by match to protein family HMM PF02798 YP_002046404.1 identified by match to protein family HMM PF00043; match to protein family HMM PF02798 YP_002046405.1 identified by match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM PF08338; match to protein family HMM TIGR01777 YP_002046406.1 identified by match to protein family HMM PF00005 YP_002046407.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_002046408.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_002046409.1 identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096 YP_002046410.1 identified by match to protein family HMM PF00497; match to protein family HMM TIGR01096 YP_002046412.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate YP_002046413.1 identified by match to protein family HMM PF00324 YP_002046414.1 identified by match to protein family HMM PF01168 YP_002046415.1 identified by match to protein family HMM PF00324 YP_002046416.1 identified by match to protein family HMM PF00278; match to protein family HMM PF02784 YP_002046417.1 identified by match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM PF07728; match to protein family HMM PF08448; match to protein family HMM TIGR00229 YP_002046418.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_002046419.1 membrane protein required for colicin V production YP_002046420.1 identified by match to protein family HMM PF05036 YP_002046421.1 identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499 YP_002046422.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_002046423.1 identified by match to protein family HMM PF09335 YP_002046424.1 'mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability' YP_002046425.1 identified by match to protein family HMM PF01118; match to protein family HMM PF02774 YP_002046426.1 identified by match to protein family HMM PF00389; match to protein family HMM PF02826 YP_002046427.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein YP_002046428.1 identified by match to protein family HMM PF07690 YP_002046433.1 identified by match to protein family HMM PF02517 YP_002046434.1 'FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP' YP_002046435.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_002046436.1 identified by match to protein family HMM PF08891 YP_002046437.1 identified by match to protein family HMM PF04315 YP_002046438.1 identified by match to protein family HMM PF01925 YP_002046439.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_002046440.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_002046441.1 identified by match to protein family HMM PF01713 YP_002046442.1 identified by match to protein family HMM TIGR00249 YP_002046443.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate YP_002046444.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth YP_002046445.1 identified by match to protein family HMM PF04175; match to protein family HMM TIGR00743 YP_002046446.1 identified by glimmer; putative YP_002046447.1 identified by match to protein family HMM PF03349 YP_002046448.1 identified by match to protein family HMM PF04333 YP_002046450.1 identified by match to protein family HMM PF00589 YP_002046452.1 identified by glimmer; putative YP_002046454.1 identified by match to protein family HMM PF06048; match to protein family HMM PF08273 YP_002046460.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA YP_002046461.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954 YP_002046462.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518 YP_002046465.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00881 YP_002046467.1 identified by glimmer; putative YP_002046468.1 identified by glimmer; putative YP_002046469.1 identified by match to protein family HMM PF01797 YP_002046470.1 identified by match to protein family HMM PF00155 YP_002046471.1 identified by glimmer; putative YP_002046472.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_002046473.1 identified by match to protein family HMM PF00654 YP_002046474.1 identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776 YP_002046475.1 identified by match to protein family HMM PF00248 YP_002046477.2 identified by match to protein family HMM PF01566; match to protein family HMM TIGR01197 YP_002046478.1 identified by match to protein family HMM PF01773; match to protein family HMM PF07662; match to protein family HMM PF07670; match to protein family HMM TIGR00804 YP_002046479.1 identified by match to protein family HMM PF00563; match to protein family HMM PF05231 YP_002046480.1 identified by match to protein family HMM PF07037 YP_002046481.1 identified by match to protein family HMM PF07037 YP_002046482.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_002046483.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002046484.1 identified by match to protein family HMM TIGR03510 YP_002046485.1 identified by match to protein family HMM PF03825; match to protein family HMM PF07690; match to protein family HMM TIGR00889 YP_002046486.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_002046487.1 identified by match to protein family HMM PF07135 YP_002046488.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002046489.1 identified by match to protein family HMM PF01758 YP_002046491.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_002046492.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure YP_002046493.2 putative role in sulfur assimilation YP_002046494.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_002046496.1 identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003 YP_002046497.1 'Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system' YP_002046498.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_002046500.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_002046501.1 identified by match to protein family HMM PF00155; match to protein family HMM PF00392 YP_002046502.1 Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group YP_002046504.1 identified by match to protein family HMM PF08238 YP_002046505.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_002046506.1 identified by match to protein family HMM PF00005; match to protein family HMM TIGR00968 YP_002046507.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import YP_002046508.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR00969; match to protein family HMM TIGR02139 YP_002046509.1 identified by match to protein family HMM PF01547; match to protein family HMM TIGR00971 YP_002046510.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01370; match to protein family HMM PF08659 YP_002046511.1 identified by match to protein family HMM PF04261; match to protein family HMM TIGR01413 YP_002046512.1 identified by match to protein family HMM PF06572 YP_002046514.1 identified by match to protein family HMM PF00583 YP_002046515.1 identified by match to protein family HMM PF01520; match to protein family HMM TIGR01409 YP_002046516.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_002046517.1 identified by glimmer; putative YP_002046518.1 identified by glimmer; putative YP_002046519.1 activates the transcription of the ethanolamine utilization operon YP_002046520.1 identified by match to protein family HMM PF00936 YP_002046521.1 identified by match to protein family HMM PF00936 YP_002046522.1 catalyzes the formation of acetaldehyde from ethanolamine YP_002046523.1 identified by match to protein family HMM PF06751 YP_002046524.1 ethanolamine utilization protein EutA YP_002046525.1 identified by match to protein family HMM PF04346 YP_002046526.1 identified by match to protein family HMM PF00465 YP_002046527.1 identified by match to protein family HMM TIGR02529 YP_002046528.1 identified by match to protein family HMM PF00171 YP_002046529.1 identified by match to protein family HMM PF03319 YP_002046530.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_002046531.1 identified by match to protein family HMM PF01923 YP_002046532.1 identified by match to protein family HMM PF05899; match to protein family HMM PF06249 YP_002046533.1 identified by match to protein family HMM TIGR02528 YP_002046534.1 identified by match to protein family HMM PF00936 YP_002046535.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_002046536.1 identified by match to protein family HMM PF00923; match to protein family HMM TIGR00874 YP_002046537.1 'catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase' YP_002046539.1 identified by match to protein family HMM PF06674 YP_002046540.1 identified by match to protein family HMM PF00293; match to protein family HMM TIGR00052 YP_002046541.1 identified by match to protein family HMM PF00144 YP_002046542.1 'unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)' YP_002046543.1 identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF07730 YP_002046544.1 identified by match to protein family HMM PF00873; match to protein family HMM TIGR00915 YP_002046545.1 identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617 YP_002046546.1 'dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.' YP_002046548.1 identified by match to protein family HMM PF00583; match to protein family HMM PF05127 YP_002046549.1 identified by match to protein family HMM PF04228 YP_002046550.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_002046551.1 identified by match to protein family HMM PF06804 YP_002046552.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_002046553.1 negative transcriptional regulator of the gcvTHP operon YP_002046554.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine YP_002046556.1 identified by match to protein family HMM PF01594 YP_002046557.1 identified by match to protein family HMM PF01435 YP_002046558.1 identified by match to protein family HMM PF03960; match to protein family HMM TIGR00014 YP_002046559.1 'controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP' YP_002046560.1 identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801 YP_002046561.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_002046562.1 identified by glimmer; putative YP_002046563.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_002046564.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_002046565.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_002046566.1 identified by match to protein family HMM PF02541 YP_002046567.1 identified by match to protein family HMM PF00563; match to protein family HMM PF05231 YP_002046570.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_002046571.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_002046572.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_002046573.1 identified by match to protein family HMM PF05688; match to protein family HMM PF05689 YP_002046575.1 identified by glimmer; putative YP_002046577.1 identified by match to protein family HMM PF07191 YP_002046578.1 'with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis' YP_002046580.1 'catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG' YP_002046581.1 'catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis' YP_002046582.1 identified by match to protein family HMM PF01381 YP_002046583.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_002046584.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_002046585.1 identified by match to protein family HMM PF00037 YP_002046587.1 identified by match to protein family HMM PF00037; match to protein family HMM TIGR02951 YP_002046588.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR02166 YP_002046589.1 penicillin-insensitive transglycosylase/transpeptidase YP_002046590.1 identified by match to protein family HMM PF01835; match to protein family HMM PF07703 YP_002046591.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds YP_002046595.1 identified by glimmer; putative YP_002046596.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I YP_002046597.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_002046598.1 identified by match to protein family HMM PF04384; match to protein family HMM TIGR03412 YP_002046599.1 identified by match to protein family HMM PF00111; match to protein family HMM TIGR02007 YP_002046600.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_002046601.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_002046602.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein YP_002046603.1 identified by match to protein family HMM PF01592; match to protein family HMM TIGR01999 YP_002046604.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_002046605.1 regulates the expression of the iscRSUA operon YP_002046606.1 identified by match to protein family HMM PF00588; match to protein family HMM TIGR00050 YP_002046607.1 identified by match to protein family HMM PF00459 YP_002046609.1 identified by match to protein family HMM TIGR02910 YP_002046610.1 with AsrAC catalyzes the reduction of sulfite to hydrogen sulfide YP_002046611.1 identified by match to protein family HMM PF00037; match to protein family HMM PF01077; match to protein family HMM PF03460; match to protein family HMM TIGR02912 YP_002046612.1 identified by match to protein family HMM PF03824 YP_002046613.1 identified by match to protein family HMM PF06226 YP_002046614.1 identified by match to protein family HMM PF00874 YP_002046615.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters YP_002046616.1 'catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate' YP_002046618.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine YP_002046619.1 regulates the cadBA operon YP_002046620.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein YP_002046621.1 identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711 YP_002046622.1 identified by match to protein family HMM PF00854; match to protein family HMM PF07690; match to protein family HMM TIGR00924 YP_002046623.1 'indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA' YP_002046624.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF07728 YP_002046626.1 identified by glimmer; putative YP_002046627.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002046629.1 'YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function' YP_002046630.1 identified by match to protein family HMM PF00383 YP_002046631.1 identified by match to protein family HMM TIGR01545 YP_002046632.1 identified by match to protein family HMM PF00367; match to protein family HMM PF02378 YP_002046633.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_002046634.1 identified by match to protein family HMM PF01380; match to protein family HMM PF01418 YP_002046635.1 identified by match to protein family HMM PF02558; match to protein family HMM PF08546; match to protein family HMM TIGR00745 YP_002046636.1 identified by match to protein family HMM PF07690 YP_002046637.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002046638.1 identified by match to protein family HMM PF00037 YP_002046639.1 'Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids' YP_002046640.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_002046641.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_002046642.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_002046643.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_002046644.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins YP_002046645.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_002046646.1 involved in the reduction of the SoxR iron-sulfur cluster YP_002046647.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP YP_002046648.1 identified by match to protein family HMM PF03872; match to protein family HMM PF03873 YP_002046649.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_002046650.1 identified by glimmer; putative YP_002046651.1 catalyzes the formation of oxaloacetate from L-aspartate YP_002046652.1 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_002046653.1 identified by match to protein family HMM PF03466 YP_002046654.1 identified by match to protein family HMM PF01810 YP_002046655.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_002046656.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_002046657.1 identified by match to protein family HMM PF00588; match to protein family HMM PF08032 YP_002046658.1 identified by match to protein family HMM PF00085; match to protein family HMM PF08534; match to protein family HMM TIGR01068 YP_002046659.1 identified by match to protein family HMM PF03942 YP_002046660.1 identified by match to protein family HMM PF00583; match to protein family HMM PF02629 YP_002046661.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_002046663.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883 YP_002046666.1 identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; match to protein family HMM TIGR03346 YP_002046667.1 identified by match to protein family HMM PF02578; match to protein family HMM TIGR00726 YP_002046668.1 'responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA' YP_002046669.1 'with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline' YP_002046670.1 associated with 30S ribosomal subunit; interferes with translation elongation YP_002046671.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_002046672.1 identified by match to protein family HMM PF08450 YP_002046673.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_002046674.1 'catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive' YP_002046677.2 identified by match to protein family HMM PF00672; match to protein family HMM PF00990; match to protein family HMM TIGR00254 YP_002046678.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_002046679.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_002046680.1 Essential for efficient processing of 16S rRNA YP_002046681.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_002046682.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins YP_002046683.1 identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471 YP_002046685.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_002046686.1 catalyzes the phosphorylation of NAD to NADP YP_002046687.1 identified by match to protein family HMM PF02463; match to protein family HMM TIGR00634 YP_002046688.1 identified by match to protein family HMM PF04355 YP_002046689.1 identified by match to protein family HMM PF03658 YP_002046690.1 identified by match to protein family HMM PF03364 YP_002046691.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_002046692.1 identified by glimmer; putative YP_002046693.1 identified by match to protein family HMM TIGR01965 YP_002046694.1 identified by match to protein family HMM PF02321; match to protein family HMM TIGR01844 YP_002046695.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM TIGR03375 YP_002046696.1 identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843 YP_002046698.1 identified by match to protein family HMM PF02810 YP_002046700.1 identified by match to protein family HMM PF05930 YP_002046701.1 identified by match to protein family HMM PF06048 YP_002046702.1 identified by glimmer; putative YP_002046705.1 identified by glimmer; putative YP_002046706.1 identified by match to protein family HMM PF01381 YP_002046708.1 identified by match to protein family HMM PF03608 YP_002046709.1 identified by match to protein family HMM PF03829 YP_002046710.1 identified by match to protein family HMM PF03612; match to protein family HMM PF07663 YP_002046711.1 identified by match to protein family HMM PF01408; match to protein family HMM PF02894 YP_002046713.1 identified by match to protein family HMM PF00215; match to protein family HMM TIGR03128 YP_002046714.1 identified by match to protein family HMM PF01380; match to protein family HMM TIGR03127 YP_002046715.1 identified by match to protein family HMM PF06560 YP_002046716.1 identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR02002 YP_002046717.1 identified by match to protein family HMM PF00496 YP_002046723.1 identified by glimmer; putative YP_002046724.1 identified by match to protein family HMM PF01527 YP_002046726.1 identified by match to protein family HMM PF01527 YP_002046727.1 identified by match to protein family HMM PF00665 YP_002046728.2 identified by match to protein family HMM PF03614 YP_002046729.1 'structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes' YP_002046730.1 identified by match to protein family HMM PF00239; match to protein family HMM PF02796 YP_002046731.1 identified by match to protein family HMM PF06722 YP_002046732.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664 YP_002046733.1 identified by match to protein family HMM PF00756 YP_002046735.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_002046736.1 identified by match to protein family HMM PF00805 YP_002046737.1 identified by match to protein family HMM PF04393 YP_002046738.1 identified by glimmer; putative YP_002046739.1 identified by match to protein family HMM PF07395 YP_002046740.1 identified by glimmer; putative YP_002046741.1 identified by glimmer; putative YP_002046743.1 identified by match to protein family HMM PF03824; match to protein family HMM TIGR00802 YP_002046744.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF08521 YP_002046745.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_002046746.1 identified by match to protein family HMM PF03401 YP_002046748.1 identified by match to protein family HMM PF01970 YP_002046750.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate YP_002046751.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent YP_002046752.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_002046753.1 identified by match to protein family HMM PF00324; match to protein family HMM TIGR01773 YP_002046754.1 regulator of gab gene expression YP_002046755.1 identified by match to protein family HMM PF01476; match to protein family HMM PF04972 YP_002046756.1 identified by match to protein family HMM PF01679 YP_002046757.1 identified by match to protein family HMM PF01022 YP_002046758.1 identified by match to protein family HMM PF00581 YP_002046760.1 identified by match to protein family HMM PF00816 YP_002046762.1 identified by match to protein family HMM PF06610 YP_002046763.1 identified by match to protein family HMM PF09400 YP_002046764.1 identified by match to protein family HMM PF05957 YP_002046765.1 with aminotransferase domain; identified by match to protein family HMM PF00155; match to protein family HMM PF00392 YP_002046766.1 identified by match to protein family HMM PF02627; match to protein family HMM TIGR00778 YP_002046768.1 identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194 YP_002046769.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_002046770.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002046771.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_002046772.1 with ProWX is involved in the high-affinity uptake of glycine betaine YP_002046773.1 with ProVX is involved in the high-affinity uptake of glycine betaine YP_002046774.1 'with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine' YP_002046775.1 identified by match to protein family HMM PF07690 YP_002046776.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB YP_002046777.1 identified by match to protein family HMM PF00529; match to protein family HMM TIGR00998 YP_002046778.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711 YP_002046781.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_002046782.1 involved in the first step of glutathione biosynthesis YP_002046784.1 'YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent' YP_002046785.1 identified by glimmer; putative YP_002046786.1 affects carbohydrate metabolism; has regulatory role in many processes YP_002046787.1 'Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA' YP_002046788.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_002046789.1 'catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs' YP_002046790.1 identified by match to protein family HMM PF02464; match to protein family HMM TIGR00199 YP_002046791.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan YP_002046792.1 identified by match to protein family HMM PF03608; match to protein family HMM TIGR00821 YP_002046793.1 identified by match to protein family HMM PF03612; match to protein family HMM PF07663; match to protein family HMM TIGR00825 YP_002046794.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002046795.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate YP_002046796.1 regulator for glucitol utilization YP_002046797.1 regulates genes involved in glucitol utilization YP_002046798.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate YP_002046799.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_002046800.1 detoxifies nitric oxide using NADH YP_002046801.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase YP_002046802.1 identified by match to protein family HMM PF00708; match to protein family HMM PF01300; match to protein family HMM PF07503; match to protein family HMM TIGR00143 YP_002046803.1 involved in electron transport from formate to hydrogen YP_002046806.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE YP_002046807.1 identified by match to protein family HMM PF07450 YP_002046808.1 identified by match to protein family HMM PF01058 YP_002046809.1 'electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate' YP_002046810.1 identified by match to protein family HMM PF00329; match to protein family HMM PF00346 YP_002046811.1 identified by match to protein family HMM PF00146 YP_002046812.1 'catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3)' YP_002046813.1 identified by match to protein family HMM PF00037 YP_002046815.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon YP_002046816.1 identified by glimmer; putative YP_002046817.1 plays a role in hydrogenase nickel cofactor insertion YP_002046818.1 GTP hydrolase involved in nickel liganding into hydrogenases YP_002046819.1 'HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase' YP_002046820.1 identified by match to protein family HMM PF01924; match to protein family HMM TIGR00075 YP_002046821.1 identified by match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR02124 YP_002046822.1 identified by match to protein family HMM PF00158; match to protein family HMM PF01590; match to protein family HMM PF02954; match to protein family HMM PF07728 YP_002046824.1 identified by match to protein family HMM PF01297 YP_002046825.1 identified by match to protein family HMM PF00005 YP_002046826.1 identified by match to protein family HMM PF00950; match to protein family HMM PF01032 YP_002046827.1 identified by match to protein family HMM PF00950 YP_002046828.1 identified by match to protein family HMM PF03421 YP_002046830.1 identified by match to protein family HMM PF00165 YP_002046833.1 identified by match to protein family HMM PF09482; match to protein family HMM TIGR02555 YP_002046834.1 identified by match to protein family HMM PF01514; match to protein family HMM TIGR02544 YP_002046836.1 identified by match to protein family HMM PF09392; match to protein family HMM TIGR02105 YP_002046837.2 identified by match to protein family HMM PF09480; match to protein family HMM TIGR02554 YP_002046838.1 identified by match to protein family HMM PF00165 YP_002046839.1 Activates the expression of invasion genes and activates the expression of prgHIJK which is part of the pathogenicity island 1 type III secretion system YP_002046840.1 identified by match to protein family HMM PF01464 YP_002046841.1 identified by match to protein family HMM PF05932 YP_002046843.1 carries the fatty acid chain in fatty acid biosynthesis YP_002046844.1 identified by match to protein family HMM PF09052 YP_002046845.1 identified by match to protein family HMM PF03518 YP_002046846.1 identified by match to protein family HMM PF07720; match to protein family HMM TIGR02552 YP_002046847.1 Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins YP_002046848.1 identified by match to protein family HMM PF01311; match to protein family HMM TIGR01401 YP_002046849.1 identified by match to protein family HMM PF01313; match to protein family HMM TIGR01403 YP_002046850.1 part of a type III secretory system probably involved in invasion into eukaryotic cells YP_002046851.1 involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells YP_002046852.1 identified by match to protein family HMM PF02510 YP_002046853.1 identified by match to protein family HMM PF02090 YP_002046854.1 Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase YP_002046855.1 identified by match to protein family HMM PF03519 YP_002046856.1 identified by match to protein family HMM PF00771; match to protein family HMM TIGR01399 YP_002046857.1 identified by match to protein family HMM PF02523; match to protein family HMM TIGR02568 YP_002046858.1 identified by match to protein family HMM PF00263; match to protein family HMM PF03958; match to protein family HMM TIGR02516 YP_002046859.1 identified by match to protein family HMM PF00165 YP_002046860.1 identified by match to protein family HMM PF04741 YP_002046862.1 identified by match to protein family HMM PF08681 YP_002046863.1 identified by match to protein family HMM PF00583 YP_002046864.1 identified by match to protein family HMM PF00149 YP_002046867.1 This protein performs the mismatch recognition step during the DNA repair process YP_002046869.1 identified by match to protein family HMM PF07690 YP_002046870.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002046871.1 identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM PF06808; match to protein family HMM TIGR00791 YP_002046872.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993 YP_002046873.1 identified by match to protein family HMM PF01261 YP_002046874.1 identified by match to protein family HMM PF00596 YP_002046875.1 identified by match to protein family HMM PF07005 YP_002046876.1 identified by match to protein family HMM PF03446 YP_002046877.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279 YP_002046878.1 identified by match to protein family HMM PF01047 YP_002046879.1 identified by match to protein family HMM PF02441; match to protein family HMM TIGR00421 YP_002046880.1 identified by match to protein family HMM PF01977; match to protein family HMM TIGR00148 YP_002046882.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses YP_002046883.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus YP_002046884.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_002046885.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_002046886.1 catalyzes the modification of U13 in tRNA(Glu) YP_002046887.1 'catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate' YP_002046888.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_002046889.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_002046891.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis YP_002046892.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ YP_002046893.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_002046894.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3 YP_002046895.1 identified by match to protein family HMM PF09707; match to protein family HMM TIGR01873 YP_002046896.1 identified by match to protein family HMM TIGR00287 YP_002046897.1 identified by match to protein family HMM PF08798; match to protein family HMM TIGR01907 YP_002046898.1 (Cas_Cas5e); identified by match to protein family HMM PF09708; match to protein family HMM TIGR01868; match to protein family HMM TIGR02593 YP_002046899.1 identified by match to protein family HMM PF09344; match to protein family HMM TIGR01869 YP_002046900.1 identified by match to protein family HMM PF09485; match to protein family HMM TIGR02548 YP_002046901.1 identified by match to protein family HMM PF09481; match to protein family HMM TIGR02547 YP_002046902.1 identified by match to protein family HMM TIGR01587 YP_002046904.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_002046905.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_002046906.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity YP_002046907.1 identified by match to protein family HMM PF01242; match to protein family HMM TIGR00039; match to protein family HMM TIGR03367 YP_002046908.1 identified by match to protein family HMM PF00753 YP_002046910.1 identified by glimmer; putative YP_002046911.1 identified by match to protein family HMM PF04055 YP_002046912.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002046913.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_002046914.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_002046915.1 identified by match to protein family HMM PF00419 YP_002046916.1 identified by match to protein family HMM PF00577 YP_002046917.1 identified by match to protein family HMM PF00345 YP_002046918.1 identified by match to protein family HMM PF00419 YP_002046919.1 identified by match to protein family HMM PF00419 YP_002046920.1 identified by match to protein family HMM PF00419 YP_002046923.1 identified by match to protein family HMM PF05016 YP_002046924.1 identified by match to protein family HMM PF01402; match to protein family HMM PF03693; match to protein family HMM TIGR02606 YP_002046925.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP YP_002046926.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_002046927.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system YP_002046928.1 identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045 YP_002046929.1 identified by match to protein family HMM PF01188; match to protein family HMM TIGR03247 YP_002046930.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746 YP_002046931.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00893 YP_002046933.1 'An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group' YP_002046934.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp YP_002046935.1 identified by match to protein family HMM PF04287 YP_002046936.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function YP_002046937.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_002046938.1 identified by match to protein family HMM PF03641 YP_002046939.1 identified by glimmer; putative YP_002046940.1 identified by match to protein family HMM TIGR00814 YP_002046941.1 identified by match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720 YP_002046942.2 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups YP_002046943.1 identified by match to protein family HMM PF00465; match to protein family HMM TIGR02638 YP_002046944.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate YP_002046946.1 identified by glimmer; putative YP_002046947.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00885 YP_002046948.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose YP_002046949.1 identified by match to protein family HMM PF00370; match to protein family HMM PF02782; match to protein family HMM TIGR02628 YP_002046950.1 identified by match to protein family HMM PF05025 YP_002046951.1 regulates expression of genes involved in L-fucose utilization YP_002046953.1 identified by match to protein family HMM PF04241 YP_002046954.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_002046955.1 identified by match to protein family HMM PF06004 YP_002046956.1 identified by match to protein family HMM PF00266; match to protein family HMM TIGR03392 YP_002046957.1 identified by match to protein family HMM PF02657; match to protein family HMM TIGR03391 YP_002046958.1 identified by glimmer; putative YP_002046959.1 identified by match to protein family HMM PF00892; match to protein family HMM TIGR00688 YP_002046960.1 identified by match to protein family HMM PF00899 YP_002046961.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_002046962.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_002046963.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_002046964.1 identified by match to protein family HMM PF00675; match to protein family HMM PF05193 YP_002046965.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination YP_002046966.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532 YP_002046967.1 alternate name YgdB, URF2; orf of X03966; 2nd start; ORF_f121 YP_002046968.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532 YP_002046969.1 identified by match to protein family HMM TIGR02532 YP_002046971.1 'ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived' YP_002046972.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_002046973.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr YP_002046974.1 hydrolyzes diadenosine polyphosphate YP_002046975.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_002046976.1 identified by match to protein family HMM PF03741 YP_002046977.1 identified by match to protein family HMM PF06004 YP_002046978.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH YP_002046979.1 identified by match to protein family HMM PF07690 YP_002046980.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 YP_002046982.1 controls transcription of galETKM YP_002046983.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532 YP_002046984.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding YP_002046985.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase YP_002046986.1 identified by match to protein family HMM PF01177; match to protein family HMM TIGR00035 YP_002046987.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00879 YP_002046988.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate YP_002046989.1 '4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate' YP_002046990.1 identified by glimmer; putative YP_002046991.1 identified by glimmer; putative YP_002046992.1 'Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis' YP_002046993.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002046994.1 identified by match to protein family HMM PF05232 YP_002046996.1 identified by match to protein family HMM PF02583 YP_002046997.1 membrane protein conferring nickel and cobalt resistance YP_002046999.1 identified by match to protein family HMM PF07180 YP_002047001.1 identified by match to protein family HMM PF00345 YP_002047002.1 identified by match to protein family HMM PF00577 YP_002047003.1 identified by match to protein family HMM PF00419 YP_002047005.1 identified by match to protein family HMM PF06316 YP_002047007.1 identified by match to protein family HMM PF01380 YP_002047008.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01370; match to protein family HMM PF08659 YP_002047009.1 identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163 YP_002047010.1 identified by match to protein family HMM PF03611 YP_002047012.1 identified by match to protein family HMM PF00359 YP_002047013.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279 YP_002047014.1 identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689 YP_002047015.1 identified by match to protein family HMM PF03611 YP_002047016.1 identified by match to protein family HMM PF02302 YP_002047017.1 identified by match to protein family HMM PF00359 YP_002047018.1 identified by match to protein family HMM PF04198 YP_002047020.1 regulates the expression of of the arsRBC involved in resistance to arsenic YP_002047021.1 identified by match to protein family HMM PF00589 YP_002047022.1 identified by match to protein family HMM PF01476; match to protein family HMM PF01551 YP_002047023.1 identified by glimmer; putative YP_002047024.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate YP_002047025.1 'class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1' YP_002047026.1 5'-3' single-stranded-DNA-specific exonuclease YP_002047027.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity YP_002047028.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002047029.1 'An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic' YP_002047030.1 identified by match to protein family HMM PF07254 YP_002047031.1 identified by match to protein family HMM PF03937 YP_002047033.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator YP_002047034.1 identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065 YP_002047035.1 identified by match to protein family HMM PF04266 YP_002047036.1 identified by match to protein family HMM PF00232 YP_002047038.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_002047039.1 'part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor' YP_002047040.1 'catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein' YP_002047041.1 identified by glimmer; putative YP_002047042.1 identified by match to protein family HMM PF01494; match to protein family HMM TIGR01988 YP_002047043.1 'Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone' YP_002047044.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide YP_002047045.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_002047046.1 identified by match to protein family HMM PF05164 YP_002047047.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function YP_002047048.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_002047049.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_002047051.1 identified by match to protein family HMM PF04402 YP_002047052.1 Involved in the export of arginine YP_002047053.1 identified by glimmer; putative YP_002047054.1 participates in the regulation of osmotic pressure changes within the cel YP_002047055.1 'catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate' YP_002047056.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_002047057.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate YP_002047058.1 identified by match to protein family HMM PF03479 YP_002047060.1 identified by match to protein family HMM PF02361 YP_002047061.1 identified by match to protein family HMM PF00005 YP_002047062.1 identified by match to protein family HMM PF00005 YP_002047063.1 'catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase' YP_002047064.1 identified by match to protein family HMM PF01609 YP_002047065.1 identified by match to protein family HMM PF01435 YP_002047066.1 catalyzes the formation of putrescine from agmatine YP_002047067.1 identified by match to protein family HMM PF00561 YP_002047068.1 identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022 YP_002047069.1 identified by match to protein family HMM PF02615 YP_002047070.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240 YP_002047071.1 identified by match to protein family HMM PF01232; match to protein family HMM PF08125 YP_002047072.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729 YP_002047074.2 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_002047077.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_002047078.1 identified by glimmer; putative YP_002047079.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00879 YP_002047080.1 identified by match to protein family HMM PF03926 YP_002047081.1 identified by match to protein family HMM PF04231 YP_002047082.2 'in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase' YP_002047083.1 'catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione' YP_002047084.1 identified by match to protein family HMM PF02622 YP_002047085.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_002047086.1 identified by match to protein family HMM PF09339 YP_002047087.1 identified by match to protein family HMM PF00437; match to protein family HMM TIGR01420 YP_002047088.1 identified by match to protein family HMM PF01168; match to protein family HMM TIGR00044 YP_002047089.1 identified by match to protein family HMM PF02325 YP_002047090.1 identified by match to protein family HMM PF02594; match to protein family HMM TIGR00251 YP_002047091.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_002047092.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002047093.1 identified by match to protein family HMM PF06717 YP_002047094.1 'catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis' YP_002047097.1 identified by match to protein family HMM PF04320 YP_002047098.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_002047099.1 identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084 YP_002047100.1 identified by match to protein family HMM PF04362 YP_002047101.1 'Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues' YP_002047102.1 identified by glimmer; putative YP_002047103.1 identified by match to protein family HMM PF03825; match to protein family HMM TIGR00889 YP_002047104.1 identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711 YP_002047105.1 identified by glimmer; putative YP_002047106.1 identified by match to protein family HMM PF04474 YP_002047107.1 identified by glimmer; putative YP_002047108.1 identified by match to protein family HMM PF02550 YP_002047109.1 identified by match to protein family HMM PF01575 YP_002047110.1 identified by match to protein family HMM PF03328 YP_002047111.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002047112.1 identified by match to protein family HMM PF00884 YP_002047113.1 identified by match to protein family HMM PF04055 YP_002047114.1 identified by match to protein family HMM PF00196 YP_002047116.1 identified by match to protein family HMM PF00324 YP_002047117.1 identified by glimmer; putative YP_002047118.1 identified by match to protein family HMM PF05899 YP_002047119.1 identified by match to protein family HMM PF01266 YP_002047120.1 identified by match to protein family HMM PF00171 YP_002047122.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS YP_002047123.1 identified by match to protein family HMM PF05638; match to protein family HMM TIGR03344 YP_002047125.1 identified by match to protein family HMM PF01522 YP_002047126.1 identified by match to protein family HMM PF00795 YP_002047127.1 identified by glimmer; putative YP_002047128.1 identified by match to protein family HMM PF07690 YP_002047129.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_002047130.1 identified by match to protein family HMM PF01232; match to protein family HMM PF08125 YP_002047131.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_002047132.1 identified by match to protein family HMM PF00015 YP_002047134.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction YP_002047135.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli YP_002047137.1 identified by match to protein family HMM PF01497 YP_002047138.1 identified by match to protein family HMM PF01455; match to protein family HMM TIGR00074 YP_002047139.1 plays a role in hydrogenase nickel cofactor insertion YP_002047141.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC) YP_002047142.1 involved in hydrogen uptake YP_002047143.1 'HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits' YP_002047144.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2 YP_002047145.1 involved in hydrogen uptake YP_002047148.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672 YP_002047149.1 identified by match to protein family HMM PF03350; match to protein family HMM TIGR00645 YP_002047153.1 identified by match to protein family HMM PF00106 YP_002047154.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_002047155.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_002047157.1 catalyzes the formation of L-homocysteine from cystathionine YP_002047158.1 identified by match to protein family HMM PF09335 YP_002047159.1 identified by glimmer; putative YP_002047160.1 identified by match to protein family HMM PF00465 YP_002047161.1 'methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate' YP_002047162.1 identified by match to protein family HMM PF01230 YP_002047163.1 identified by glimmer; putative YP_002047164.1 identified by match to protein family HMM PF04055; match to protein family HMM PF08497 YP_002047165.1 identified by match to protein family HMM PF03480; match to protein family HMM TIGR00787 YP_002047166.1 identified by match to protein family HMM PF04290 YP_002047167.1 identified by match to protein family HMM PF06808; match to protein family HMM TIGR00786 YP_002047168.1 identified by match to protein family HMM PF07731; match to protein family HMM PF07732; match to protein family HMM TIGR01409 YP_002047169.1 identified by match to protein family HMM PF01553; match to protein family HMM TIGR00530 YP_002047170.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002047171.1 identified by match to protein family HMM PF00165; match to protein family HMM PF06445 YP_002047172.1 identified by match to protein family HMM PF04076; match to protein family HMM TIGR00156 YP_002047173.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes YP_002047174.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518 YP_002047175.1 identified by match to protein family HMM PF02525 YP_002047176.1 identified by match to protein family HMM PF03992 YP_002047177.1 identified by glimmer; putative YP_002047178.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002047179.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_002047180.1 identified by match to protein family HMM PF00149; match to protein family HMM PF08413 YP_002047181.1 identified by match to protein family HMM PF06853 YP_002047182.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_002047183.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell YP_002047185.1 identified by match to protein family HMM PF03738 YP_002047186.1 'seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine' YP_002047187.1 identified by match to protein family HMM PF02535 YP_002047189.1 identified by match to protein family HMM PF05935 YP_002047190.1 identified by match to protein family HMM PF01323 YP_002047192.1 DHBP synthase; functions during riboflavin biosynthesis YP_002047193.1 identified by match to protein family HMM PF04380 YP_002047194.1 Involved in glycogen synthesis. May be involved in glycogen priming YP_002047196.1 identified by match to protein family HMM PF07290 YP_002047197.1 identified by match to protein family HMM PF01145 YP_002047198.1 'catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose' YP_002047199.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_002047200.1 identified by match to protein family HMM PF01928; match to protein family HMM PF05235 YP_002047201.1 identified by match to protein family HMM PF08239 YP_002047202.1 'catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases' YP_002047203.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_002047204.1 'catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin' YP_002047205.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_002047206.1 'in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity' YP_002047207.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_002047208.1 synthesizes RNA primers at the replication forks YP_002047209.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_002047210.1 identified by match to protein family HMM PF03167 YP_002047211.1 identified by glimmer; putative YP_002047216.1 identified by match to protein family HMM PF02413 YP_002047217.1 identified by match to protein family HMM PF03406 YP_002047221.1 identified by match to protein family HMM TIGR01760 YP_002047223.1 identified by glimmer; putative YP_002047226.1 identified by match to protein family HMM PF04550 YP_002047231.1 identified by match to protein family HMM PF05926 YP_002047233.1 identified by match to protein family HMM PF05944 YP_002047234.1 identified by match to protein family HMM PF05125; match to protein family HMM TIGR01551 YP_002047236.1 identified by match to protein family HMM PF03237; match to protein family HMM PF06056 YP_002047237.1 identified by match to protein family HMM PF04860; match to protein family HMM TIGR01540 YP_002047238.1 identified by glimmer; putative YP_002047239.1 identified by match to protein family HMM PF05840 YP_002047241.1 identified by match to protein family HMM PF00929 YP_002047242.1 identified by glimmer; putative YP_002047243.1 identified by glimmer; putative YP_002047244.1 identified by glimmer; putative YP_002047245.1 identified by glimmer; putative YP_002047246.1 identified by match to protein family HMM PF06892 YP_002047249.1 identified by match to protein family HMM PF00589 YP_002047250.1 identified by match to protein family HMM PF04954; match to protein family HMM PF08021 YP_002047251.1 identified by match to protein family HMM PF03551 YP_002047252.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672 YP_002047253.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF08447; match to protein family HMM TIGR00229 YP_002047255.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate YP_002047256.1 identified by match to protein family HMM PF00724; match to protein family HMM PF07992 YP_002047257.1 identified by match to protein family HMM PF05175; match to protein family HMM PF08242 YP_002047258.1 identified by match to protein family HMM PF01863 YP_002047259.1 identified by match to protein family HMM PF02698 YP_002047260.1 identified by match to protein family HMM PF01408 YP_002047261.1 identified by match to protein family HMM PF03741 YP_002047262.1 involved in the import of serine and threonine coupled with the import of sodium YP_002047263.1 identified by match to protein family HMM PF09335 YP_002047265.1 identified by match to protein family HMM PF06476 YP_002047266.1 identified by match to protein family HMM PF05957 YP_002047269.1 identified by match to protein family HMM PF07681 YP_002047271.1 identified by match to protein family HMM PF05656 YP_002047272.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002047273.1 identified by match to protein family HMM PF02678 YP_002047275.1 identified by match to protein family HMM PF06354 YP_002047276.1 identified by match to protein family HMM TIGR00814 YP_002047277.1 identified by match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720 YP_002047278.1 identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255 YP_002047279.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism YP_002047280.1 involved in the import of threonine and serine in combination with the import of a proton YP_002047281.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic YP_002047282.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation YP_002047283.1 catalyzes the reduction of tartronate semialdehyde to glycerate YP_002047284.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate YP_002047285.1 identified by glimmer; putative YP_002047286.1 identified by glimmer; putative YP_002047287.1 identified by match to protein family HMM PF04295; match to protein family HMM PF08666; match to protein family HMM TIGR03248 YP_002047288.1 'catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway' YP_002047289.1 identified by match to protein family HMM PF08013; match to protein family HMM TIGR02810 YP_002047290.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002047291.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002047292.1 identified by match to protein family HMM PF03611; match to protein family HMM TIGR00827 YP_002047293.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate YP_002047294.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220 YP_002047295.1 identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096 YP_002047296.1 identified by match to protein family HMM PF04348 YP_002047297.1 identified by match to protein family HMM PF02021; match to protein family HMM TIGR00252 YP_002047298.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein YP_002047299.1 identified by match to protein family HMM PF04972 YP_002047300.1 identified by match to protein family HMM PF01370; match to protein family HMM PF07993 YP_002047301.1 identified by match to protein family HMM PF01965; match to protein family HMM TIGR01382 YP_002047303.1 identified by match to protein family HMM PF01541 YP_002047304.1 identified by match to protein family HMM PF00583 YP_002047305.1 identified by match to protein family HMM PF02036 YP_002047306.1 identified by match to protein family HMM PF01136 YP_002047307.1 identified by match to protein family HMM PF01136 YP_002047308.1 identified by match to protein family HMM PF00296; match to protein family HMM TIGR03558 YP_002047309.1 tryptophan transporter of high affinity YP_002047310.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division YP_002047311.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing YP_002047312.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_002047313.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_002047314.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_002047315.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_002047316.1 'modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination' YP_002047317.2 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_002047318.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_002047320.1 identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810 YP_002047321.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_002047322.1 'catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate' YP_002047323.1 identified by glimmer; putative YP_002047324.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins YP_002047325.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit YP_002047326.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability YP_002047327.1 'necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus' YP_002047328.1 'penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains' YP_002047329.1 identified by glimmer; putative YP_002047330.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_002047331.1 identified by match to protein family HMM PF00892 YP_002047332.1 involved in the peptidyltransferase reaction during translation YP_002047333.1 identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061 YP_002047334.2 identified by match to protein family HMM PF00348 YP_002047335.1 activator of maltose metabolism genes YP_002047336.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002047337.1 identified by match to protein family HMM PF01722 YP_002047339.1 identified by match to protein family HMM PF05494 YP_002047340.1 identified by match to protein family HMM PF02470 YP_002047341.1 identified by match to protein family HMM PF02405; match to protein family HMM TIGR00056 YP_002047342.1 ATP-binding subunit of a putative ABC toluene efflux transporter YP_002047343.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers YP_002047344.1 identified by match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393 YP_002047345.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis YP_002047346.1 identified by match to protein family HMM PF06835 YP_002047347.1 'LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system' YP_002047348.1 identified by match to protein family HMM PF00005 YP_002047349.1 'sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen' YP_002047350.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing YP_002047351.1 identified by match to protein family HMM PF00359; match to protein family HMM TIGR01419 YP_002047352.1 identified by match to protein family HMM PF03668 YP_002047353.1 identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003 YP_002047355.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_002047356.1 identified by match to protein family HMM PF01965 YP_002047357.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA YP_002047358.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR01212 YP_002047359.1 'glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate' YP_002047360.1 identified by match to protein family HMM PF06250 YP_002047361.1 identified by match to protein family HMM PF02133 YP_002047362.1 Catalyzes the deamination of cytosine to uracil and ammonia YP_002047363.1 identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022 YP_002047364.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein YP_002047365.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_002047366.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00891 YP_002047367.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_002047368.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization YP_002047369.1 identified by match to protein family HMM PF04386 YP_002047370.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation YP_002047371.1 identified by glimmer; putative YP_002047372.1 forms a direct contact with the tRNA during translation YP_002047373.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_002047374.1 identified by match to protein family HMM PF03969 YP_002047375.1 identified by match to protein family HMM PF06295 YP_002047376.1 identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037 YP_002047377.1 identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02038 YP_002047379.1 identified by match to protein family HMM PF03977; match to protein family HMM TIGR01109 YP_002047380.1 catalyzes the formation of pyruvate from oxaloacetate YP_002047381.1 catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide YP_002047382.1 Involved in the tartrate degradation pathway YP_002047383.1 Involved in the tartrate degradation pathway YP_002047384.1 identified by match to protein family HMM PF00939; match to protein family HMM PF02040; match to protein family HMM PF03600; match to protein family HMM PF06808; match to protein family HMM TIGR00785 YP_002047385.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729 YP_002047386.1 identified by match to protein family HMM PF00392 YP_002047387.1 oxidizes malate to oxaloacetate YP_002047388.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_002047389.1 identified by match to protein family HMM PF07338 YP_002047390.1 identified by match to protein family HMM PF07338 YP_002047392.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_002047393.1 'with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate' YP_002047394.1 membrane protein AaeX; the gene is a member of the aaeXAB operon YP_002047395.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002047396.1 'responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA' YP_002047397.1 identified by match to protein family HMM TIGR02099 YP_002047398.1 involved in the processing of the 5'end of 16S rRNA YP_002047399.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002047400.1 part of cell wall structural complex MreBCD; transmembrane component YP_002047401.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_002047402.1 functions in MreBCD complex in some organisms YP_002047403.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules YP_002047404.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; match to protein family HMM TIGR02823 YP_002047405.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_002047406.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_002047407.1 'composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism' YP_002047408.1 'an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism' YP_002047409.1 identified by match to protein family HMM PF06196 YP_002047410.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_002047411.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_002047412.1 identified by match to protein family HMM PF01207; match to protein family HMM TIGR00737 YP_002047413.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_002047414.1 identified by match to protein family HMM PF01555 YP_002047416.1 identified by match to protein family HMM PF00563; match to protein family HMM PF00990; match to protein family HMM PF03707; match to protein family HMM TIGR00254 YP_002047417.1 identified by match to protein family HMM PF00440; match to protein family HMM PF08361 YP_002047419.1 identified by match to protein family HMM PF00529; match to protein family HMM TIGR01730 YP_002047420.1 identified by match to protein family HMM PF00873; match to protein family HMM TIGR00915 YP_002047423.1 identified by glimmer; putative YP_002047425.1 identified by match to protein family HMM PF07369 YP_002047426.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002047427.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA YP_002047428.1 identified by match to protein family HMM PF01396 YP_002047429.1 identified by match to protein family HMM PF04361 YP_002047430.1 identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732 YP_002047431.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002047432.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_002047433.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase YP_002047434.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_002047435.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_002047436.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators YP_002047437.1 identified by match to protein family HMM PF09350 YP_002047438.1 is a component of the macrolide binding site in the peptidyl transferase center YP_002047439.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_002047440.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_002047441.1 'located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3' YP_002047442.1 'located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA' YP_002047443.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_002047444.1 late assembly protein YP_002047445.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_002047446.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_002047447.1 binds 5S rRNA along with protein L5 and L25 YP_002047448.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_002047449.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_002047450.1 'located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif' YP_002047451.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_002047452.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_002047453.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_002047454.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_002047455.1 one of the stabilizing components for the large ribosomal subunit YP_002047456.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_002047457.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_002047458.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_002047459.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_002047460.1 'one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation' YP_002047461.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_002047462.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_002047463.1 'binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin' YP_002047464.1 identified by match to protein family HMM PF00338; match to protein family HMM TIGR01049 YP_002047465.2 identified by match to protein family HMM PF01478 YP_002047466.1 iron storage protein YP_002047467.1 identified by match to protein family HMM PF04324 YP_002047468.1 'EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu' YP_002047469.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002047470.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_002047471.1 'interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance' YP_002047472.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_002047473.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_002047474.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_002047475.1 identified by match to protein family HMM PF08348 YP_002047476.1 rotamase YP_002047477.1 identified by match to protein family HMM PF04102 YP_002047478.1 rotamase YP_002047479.1 identified by match to protein family HMM PF09526; match to protein family HMM TIGR02443 YP_002047480.1 involved in potassium efflux YP_002047481.1 required for KefB activity YP_002047482.1 identified by match to protein family HMM PF00005 YP_002047484.1 identified by match to protein family HMM PF08803 YP_002047485.1 identified by match to protein family HMM PF00561 YP_002047486.1 identified by match to protein family HMM PF06794 YP_002047487.1 identified by match to protein family HMM PF00485 YP_002047488.1 identified by match to protein family HMM PF02566 YP_002047489.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_002047490.1 identified by match to protein family HMM PF05976; match to protein family HMM TIGR01667 YP_002047491.1 'DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate' YP_002047492.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity YP_002047493.1 identified by match to protein family HMM PF02661 YP_002047495.1 identified by match to protein family HMM PF00160 YP_002047496.1 identified by match to protein family HMM PF07690 YP_002047498.1 identified by match to protein family HMM PF00070; match to protein family HMM PF01077; match to protein family HMM PF03460; match to protein family HMM PF04324; match to protein family HMM PF07992; match to protein family HMM TIGR02374 YP_002047499.1 'involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations' YP_002047501.1 member of the FNT family of formate and nitrite transporters YP_002047502.1 'multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin' YP_002047503.1 identified by match to protein family HMM PF03797 YP_002047505.1 'catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA' YP_002047506.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_002047507.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_002047508.1 identified by match to protein family HMM PF02086; match to protein family HMM TIGR00571 YP_002047509.1 identified by match to protein family HMM PF05036 YP_002047510.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_002047511.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_002047512.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa YP_002047515.1 identified by match to protein family HMM PF05137 YP_002047516.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits YP_002047517.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_002047518.1 identified by match to protein family HMM PF07095 YP_002047519.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509 YP_002047520.1 identified by match to protein family HMM PF01479 YP_002047521.1 'becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers' YP_002047523.1 identified by glimmer; putative YP_002047524.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_002047525.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR YP_002047526.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_002047527.1 'necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus' YP_002047528.1 identified by match to protein family HMM PF00575; match to protein family HMM PF09371 YP_002047529.1 identified by match to protein family HMM PF04023 YP_002047530.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake YP_002047531.1 identified by match to protein family HMM PF09012 YP_002047533.1 identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784 YP_002047534.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis YP_002047535.1 involved in high-affinity gluconate transport YP_002047536.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_002047537.1 identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM TIGR00791 YP_002047538.1 amylomaltase; acts to release glucose from maltodextrins YP_002047539.1 identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093 YP_002047540.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_002047541.1 identified by match to protein family HMM PF05016; match to protein family HMM TIGR00053; match to protein family HMM TIGR02385 YP_002047542.1 identified by match to protein family HMM PF04221; match to protein family HMM TIGR02384 YP_002047543.1 'catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester' YP_002047544.1 identified by match to protein family HMM PF01139 YP_002047545.1 identified by match to protein family HMM PF05731 YP_002047547.1 'represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism' YP_002047548.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity YP_002047549.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine YP_002047550.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_002047553.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone YP_002047554.1 identified by match to protein family HMM PF07690 YP_002047555.1 identified by match to protein family HMM PF00920 YP_002047556.1 identified by match to protein family HMM PF00701 YP_002047557.1 identified by match to protein family HMM PF01614; match to protein family HMM PF09339 YP_002047558.1 identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093 YP_002047559.1 'catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose' YP_002047560.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_002047561.1 'catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen' YP_002047562.1 'catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain' YP_002047563.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_002047564.1 identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM TIGR00791 YP_002047565.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate YP_002047566.2 identified by match to protein family HMM PF00532 YP_002047567.1 identified by match to protein family HMM PF02678; match to protein family HMM PF07883 YP_002047568.1 identified by match to protein family HMM PF01408; match to protein family HMM PF02894 YP_002047569.1 identified by glimmer; putative YP_002047570.1 YhhY; regulated by the fur regulator; unknown function YP_002047571.1 identified by glimmer; putative YP_002047572.1 identified by match to protein family HMM PF00294; match to protein family HMM PF08220; match to protein family HMM PF08543 YP_002047573.1 identified by match to protein family HMM PF07090 YP_002047575.1 identified by match to protein family HMM PF02126 YP_002047576.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides YP_002047578.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate YP_002047579.1 part of the UgpABCE glycerol-3-phosphate uptake system YP_002047580.1 with UgpABC is involved in uptake of glycerol-3-phosphate YP_002047581.1 with UgpEC is involved in the uptake of glycerol-3-phosphate YP_002047582.1 with UgpACE is involved in the uptake of glycerol-3-phosphate YP_002047583.1 identified by glimmer; putative YP_002047585.1 'with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine' YP_002047586.1 'Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine' YP_002047587.1 'Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine' YP_002047588.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter YP_002047589.1 identified by match to protein family HMM PF01094 YP_002047590.1 identified by match to protein family HMM PF00583 YP_002047592.1 identified by match to protein family HMM PF01094 YP_002047593.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_002047594.1 'putative ABC transporter, membrane protein' YP_002047595.1 'putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions' YP_002047596.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins YP_002047597.1 catalyzes the methylation of 16S rRNA at position G966 YP_002047598.1 identified by match to protein family HMM PF06611 YP_002047600.1 identified by match to protein family HMM PF07947 YP_002047601.1 'P-type ATPase involved in the export of lead, cadmium, zinc and mercury' YP_002047602.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203 YP_002047603.1 identified by match to protein family HMM PF01206 YP_002047604.1 identified by match to protein family HMM PF02592; match to protein family HMM TIGR00697 YP_002047606.1 identified by match to protein family HMM PF07690 YP_002047607.1 identified by match to protein family HMM PF01594 YP_002047608.1 identified by match to protein family HMM PF01648 YP_002047609.1 Inhibits transcription at high concentrations of nickel YP_002047610.1 identified by match to protein family HMM PF01061 YP_002047611.1 identified by match to protein family HMM PF00005; match to protein family HMM PF01061 YP_002047612.1 identified by match to protein family HMM PF00529 YP_002047613.1 identified by glimmer; putative YP_002047614.1 identified by match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR00275 YP_002047615.1 identified by match to protein family HMM PF01384 YP_002047616.1 'ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress' YP_002047617.1 identified by match to protein family HMM PF00582 YP_002047618.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function YP_002047619.1 predicted SAM-dependent methyltransferase YP_002047620.1 identified by match to protein family HMM PF01432 YP_002047621.1 identified by match to protein family HMM PF01569 YP_002047622.1 identified by match to protein family HMM PF04378 YP_002047623.1 identified by glimmer; putative YP_002047624.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_002047625.1 identified by match to protein family HMM PF00710; match to protein family HMM TIGR00520 YP_002047626.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_002047627.1 identified by match to protein family HMM PF00294 YP_002047628.1 identified by match to protein family HMM PF01380 YP_002047629.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702 YP_002047630.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose YP_002047632.1 identified by glimmer; putative YP_002047634.1 identified by match to protein family HMM PF00196; match to protein family HMM PF01726; match to protein family HMM PF08281 YP_002047635.1 identified by glimmer; putative YP_002047636.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002047637.1 identified by match to protein family HMM PF03631; match to protein family HMM TIGR00766 YP_002047638.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00883 YP_002047639.1 identified by match to protein family HMM PF05170 YP_002047640.1 in Escherichia coli this protein is involved in flagellar function YP_002047641.1 identified by match to protein family HMM PF00675; match to protein family HMM PF05193 YP_002047642.1 involved in the transport of C4-dicarboxylates across the membrane YP_002047643.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli YP_002047644.2 'cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA' YP_002047645.1 'catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans' YP_002047646.1 'binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP)' YP_002047647.1 'polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis' YP_002047648.1 identified by match to protein family HMM PF06564; match to protein family HMM TIGR03371 YP_002047651.1 identified by match to protein family HMM TIGR03369 YP_002047652.1 identified by match to protein family HMM TIGR03493 YP_002047653.1 identified by match to protein family HMM TIGR03368 YP_002047656.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_002047657.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF YP_002047658.1 identified by match to protein family HMM PF00528 YP_002047659.1 transports peptides consisting of two or three amino acids YP_002047660.1 identified by match to protein family HMM PF00496 YP_002047661.1 identified by match to protein family HMM PF00860 YP_002047663.1 identified by glimmer; putative YP_002047664.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532 YP_002047665.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide YP_002047666.1 identified by match to protein family HMM PF00419 YP_002047667.1 identified by match to protein family HMM PF00577 YP_002047668.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753 YP_002047669.1 identified by match to protein family HMM PF00419 YP_002047671.1 'constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine' YP_002047672.1 identified by match to protein family HMM PF00583 YP_002047673.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR00509 YP_002047674.1 identified by glimmer; putative YP_002047675.1 identified by match to protein family HMM PF00691; match to protein family HMM PF05433 YP_002047676.1 identified by match to protein family HMM PF00389; match to protein family HMM PF02826 YP_002047678.1 identified by glimmer; putative YP_002047680.1 identified by match to protein family HMM PF00313 YP_002047682.1 identified by match to protein family HMM PF08681 YP_002047683.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002047684.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002047687.1 identified by match to protein family HMM PF01757 YP_002047688.1 identified by match to protein family HMM PF05360 YP_002047689.1 identified by match to protein family HMM PF00370; match to protein family HMM PF02782; match to protein family HMM TIGR01312 YP_002047690.1 catalyzes the interconversion of D-xylose to D-xylulose YP_002047691.1 identified by match to protein family HMM PF00165 YP_002047692.1 identified by match to protein family HMM PF01832 YP_002047693.1 'periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds' YP_002047694.1 'transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis' YP_002047695.1 identified by match to protein family HMM PF00037 YP_002047696.1 identified by match to protein family HMM PF01614; match to protein family HMM PF09339 YP_002047697.1 'NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate' YP_002047698.1 identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022 YP_002047700.1 'membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO' YP_002047701.1 identified by match to protein family HMM PF06808; match to protein family HMM TIGR00786 YP_002047702.1 identified by match to protein family HMM PF03480; match to protein family HMM TIGR00787 YP_002047703.1 identified by match to protein family HMM PF00370; match to protein family HMM PF02782 YP_002047704.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate YP_002047705.1 'L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate' YP_002047706.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_002047707.1 identified by match to protein family HMM PF00165 YP_002047708.1 identified by match to protein family HMM PF07944 YP_002047709.1 identified by match to protein family HMM PF00171 YP_002047710.1 identified by match to protein family HMM PF00480 YP_002047711.1 identified by match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM PF09106; match to protein family HMM PF09107; match to protein family HMM TIGR00475 YP_002047712.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_002047713.1 identified by match to protein family HMM PF00043; match to protein family HMM PF02798 YP_002047714.1 identified by match to protein family HMM PF00359; match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00851 YP_002047715.1 identified by match to protein family HMM PF01232; match to protein family HMM PF08125 YP_002047716.1 Acts as a repressor of the mtlAD operon YP_002047719.1 identified by glimmer; putative YP_002047721.1 identified by match to protein family HMM PF03895; match to protein family HMM PF05658; match to protein family HMM PF05662 YP_002047722.1 identified by match to protein family HMM PF02652; match to protein family HMM TIGR00795 YP_002047723.1 represses the lctPRD operon YP_002047724.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration YP_002047725.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates YP_002047726.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532 YP_002047727.1 identified by glimmer; putative YP_002047728.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746 YP_002047729.1 identified by match to protein family HMM PF07690 YP_002047730.1 catalyzes the O-acetylation of serine YP_002047731.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_002047732.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_002047733.1 identified by match to protein family HMM PF00462; match to protein family HMM TIGR02181 YP_002047734.1 identified by match to protein family HMM PF00581 YP_002047735.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_002047736.1 identified by match to protein family HMM PF01551 YP_002047737.1 identified by match to protein family HMM PF04748 YP_002047738.1 identified by match to protein family HMM PF00535 YP_002047739.1 'converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism' YP_002047740.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_002047741.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose YP_002047742.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core YP_002047743.1 identified by match to protein family HMM PF01075; match to protein family HMM TIGR02193 YP_002047744.1 identified by match to protein family HMM PF04932 YP_002047745.1 identified by match to protein family HMM PF00534 YP_002047747.1 identified by match to protein family HMM PF06176 YP_002047748.1 identified by match to protein family HMM PF01501; match to protein family HMM PF08437 YP_002047749.1 identified by match to protein family HMM PF01501; match to protein family HMM PF08437 YP_002047750.1 identified by match to protein family HMM PF00534 YP_002047752.1 identified by match to protein family HMM PF06293 YP_002047753.1 identified by match to protein family HMM PF00534 YP_002047754.1 identified by match to protein family HMM PF01075; match to protein family HMM TIGR02201 YP_002047755.1 identified by glimmer; putative YP_002047756.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_002047757.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_002047758.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_002047759.1 'in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif' YP_002047760.1 required for 70S ribosome assembly YP_002047761.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_002047762.1 catalyzes the formation of dUMP from dUTP YP_002047763.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_002047764.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002047765.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_002047766.1 identified by match to protein family HMM PF03755; match to protein family HMM PF08340; match to protein family HMM TIGR00255 YP_002047767.1 identified by match to protein family HMM PF00126 YP_002047768.1 identified by match to protein family HMM PF00753 YP_002047769.1 identified by match to protein family HMM PF03458 YP_002047770.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+ YP_002047771.1 'Essential for recycling GMP and indirectly, cGMP' YP_002047772.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_002047773.1 identified by match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691 YP_002047774.1 specifically modifies tRNA at position G18 YP_002047775.1 catalyzes branch migration in Holliday junction intermediates YP_002047777.1 identified by match to protein family HMM PF03616; match to protein family HMM TIGR00210 YP_002047778.1 identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801 YP_002047779.1 identified by match to protein family HMM PF05170 YP_002047780.1 'catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides' YP_002047781.1 may be involved in the transport of galactosides-pentoses-hexuronides YP_002047782.1 identified by glimmer; putative YP_002047788.1 identified by match to protein family HMM PF00486 YP_002047789.1 identified by match to protein family HMM PF01609 YP_002047790.1 identified by glimmer; putative YP_002047791.1 identified by match to protein family HMM PF00857 YP_002047793.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01524 YP_002047795.1 identified by match to protein family HMM PF02308 YP_002047796.1 identified by match to protein family HMM PF00892; match to protein family HMM TIGR00950 YP_002047797.1 identified by match to protein family HMM PF04754; match to protein family HMM TIGR01784 YP_002047798.1 identified by match to protein family HMM PF07071; match to protein family HMM TIGR03581 YP_002047799.1 identified by match to protein family HMM PF03841; match to protein family HMM TIGR01437 YP_002047800.1 identified by match to protein family HMM PF03613 YP_002047801.1 identified by match to protein family HMM PF03609 YP_002047802.1 identified by match to protein family HMM PF03830 YP_002047803.1 identified by match to protein family HMM PF03610 YP_002047804.1 identified by match to protein family HMM PF00158; match to protein family HMM PF00874; match to protein family HMM PF07728 YP_002047806.1 identified by glimmer; putative YP_002047807.1 identified by match to protein family HMM PF00232 YP_002047808.1 identified by match to protein family HMM PF06296 YP_002047810.1 identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003 YP_002047811.1 'class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis' YP_002047812.1 identified by match to protein family HMM PF00370; match to protein family HMM PF02782 YP_002047813.1 identified by match to protein family HMM PF03611 YP_002047815.1 identified by match to protein family HMM PF00359 YP_002047816.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702 YP_002047817.1 identified by match to protein family HMM PF06711 YP_002047818.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate YP_002047819.1 membrane protein regulates uhpT expression YP_002047820.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph YP_002047821.1 'response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter' YP_002047823.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00885 YP_002047824.1 identified by match to protein family HMM PF00294; match to protein family HMM TIGR02152 YP_002047825.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220 YP_002047826.1 'with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit' YP_002047827.1 identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118 YP_002047828.1 identified by match to protein family HMM PF00892 YP_002047829.1 multidrug efflux protein involved in adaptation to low energy shock YP_002047830.1 regulates the synthesis and expression of the dsdXA operon and dadA gene YP_002047831.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function YP_002047832.1 catalyzes the formation of pyruvate from serine YP_002047835.1 identified by match to protein family HMM PF02656 YP_002047836.1 identified by glimmer; putative YP_002047837.1 identified by glimmer; putative YP_002047838.1 identified by match to protein family HMM PF02080; match to protein family HMM PF06826; match to protein family HMM TIGR01625 YP_002047839.1 '16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent' YP_002047840.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress YP_002047842.1 identified by match to protein family HMM PF07119 YP_002047843.1 identified by match to protein family HMM PF03918 YP_002047844.1 identified by match to protein family HMM PF00578; match to protein family HMM PF08534; match to protein family HMM TIGR00385 YP_002047845.1 identified by match to protein family HMM PF01578; match to protein family HMM TIGR00353 YP_002047846.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_002047847.1 identified by match to protein family HMM PF04995; match to protein family HMM TIGR03141 YP_002047848.1 identified by match to protein family HMM PF01578; match to protein family HMM TIGR01191 YP_002047849.1 identified by match to protein family HMM PF03379; match to protein family HMM TIGR01190 YP_002047850.1 ATP-binding protein; required for proper cytochrome c maturation YP_002047851.1 identified by match to protein family HMM PF03150 YP_002047852.1 'TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor' YP_002047853.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR00509; match to protein family HMM TIGR01409; match to protein family HMM TIGR02164 YP_002047854.1 identified by match to protein family HMM PF03264; match to protein family HMM TIGR02162 YP_002047855.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes YP_002047856.1 periplasmic sensory protein associated with the TorRS two-component regulatory system YP_002047857.1 identified by glimmer; putative YP_002047858.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide YP_002047859.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM TIGR00881; match to protein family HMM TIGR00893 YP_002047860.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746 YP_002047861.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism YP_002047862.1 identified by match to protein family HMM PF05035 YP_002047863.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729 YP_002047864.1 'YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins' YP_002047865.1 identified by match to protein family HMM PF07690 YP_002047866.1 identified by match to protein family HMM PF01188; match to protein family HMM PF02746 YP_002047867.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002047868.1 negatively supercoils closed circular double-stranded DNA YP_002047869.1 'Required for DNA replication; binds preferentially to single-stranded, linear DNA' YP_002047870.1 binds the polymerase to DNA and acts as a sliding clamp YP_002047871.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_002047872.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_002047873.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_002047874.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_002047875.1 'in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE' YP_002047876.1 Confers resistance to chloramphenicol YP_002047877.1 Involved in anaerobic NO protection YP_002047879.1 identified by match to protein family HMM PF03358 YP_002047880.1 identified by match to protein family HMM PF00860; match to protein family HMM PF00916 YP_002047881.1 'YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily' YP_002047882.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon YP_002047883.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002047884.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_002047885.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_002047886.1 identified by match to protein family HMM PF01547; match to protein family HMM TIGR00975 YP_002047887.1 identified by match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR01427 YP_002047888.1 catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002047889.1 identified by match to protein family HMM PF00496 YP_002047890.1 'Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source' YP_002047891.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_002047893.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_002047894.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_002047895.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_002047896.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_002047897.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_002047898.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_002047899.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_002047900.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_002047903.1 identified by glimmer; putative YP_002047904.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_002047905.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_002047906.1 'An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group' YP_002047907.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_002047908.1 catalyzes the formation of asparagine from aspartate and ammonia YP_002047909.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA YP_002047910.1 'interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase' YP_002047911.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH YP_002047912.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_002047913.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain YP_002047914.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B YP_002047915.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system YP_002047916.1 catalyzes the formation of D-ribose 5-phosphate from ribose YP_002047917.1 DNA-binding transcriptional repressor of ribose metabolism YP_002047918.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711 YP_002047919.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729 YP_002047920.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon YP_002047921.1 identified by match to protein family HMM PF04219 YP_002047922.1 'among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function' YP_002047923.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_002047925.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002047926.1 'catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis' YP_002047927.1 'threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway' YP_002047928.1 identified by match to protein family HMM PF05973 YP_002047930.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_002047931.1 'catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis' YP_002047932.1 identified by match to protein family HMM PF00639 YP_002047933.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication YP_002047934.1 'catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation' YP_002047935.1 'enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation' YP_002047936.1 identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068 YP_002047937.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_002047938.1 identified by match to protein family HMM PF00953; match to protein family HMM TIGR02380 YP_002047939.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein YP_002047940.1 identified by match to protein family HMM PF02350; match to protein family HMM TIGR00236 YP_002047941.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid YP_002047942.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181 YP_002047944.1 identified by match to protein family HMM PF00583; match to protein family HMM TIGR02382 YP_002047945.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis YP_002047946.1 identified by match to protein family HMM PF01943 YP_002047947.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis YP_002047948.1 enterobacterial common antigen polymerase YP_002047949.1 identified by match to protein family HMM PF03808; match to protein family HMM TIGR00696 YP_002047950.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function YP_002047951.1 identified by match to protein family HMM PF07219; match to protein family HMM PF07719; match to protein family HMM TIGR00540 YP_002047952.1 identified by match to protein family HMM PF04375 YP_002047953.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis YP_002047954.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_002047955.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_002047956.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_002047959.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_002047960.1 identified by match to protein family HMM PF04340 YP_002047961.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002047962.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function YP_002047963.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_002047964.1 responsible for the influx of magnesium ions YP_002047966.1 identified by match to protein family HMM PF00892; match to protein family HMM TIGR00688 YP_002047967.1 identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369 YP_002047968.1 catalyzes the hydrolysis of phosphatidylcholine YP_002047969.1 'functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway' YP_002047970.1 identified by match to protein family HMM PF01810; match to protein family HMM TIGR00949 YP_002047971.1 identified by match to protein family HMM PF01810; match to protein family HMM TIGR00949 YP_002047972.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates YP_002047973.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002047974.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_002047975.1 identified by glimmer; putative YP_002047976.1 identified by match to protein family HMM PF02810; match to protein family HMM PF04055 YP_002047977.2 identified by match to protein family HMM PF01738 YP_002047978.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_002047979.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner YP_002047980.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_002047981.1 identified by match to protein family HMM PF02036 YP_002047982.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions YP_002047983.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_002047984.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_002047985.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane YP_002047986.1 magnesium dependent; not involved in the Sec-independent protein export system YP_002047987.1 identified by match to protein family HMM PF02357; match to protein family HMM TIGR01955 YP_002047988.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol YP_002047989.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin YP_002047990.1 identified by match to protein family HMM PF05935 YP_002047991.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_002047992.2 'includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids' YP_002047993.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters YP_002047994.1 identified by match to protein family HMM PF01205; match to protein family HMM PF09186; match to protein family HMM TIGR00257 YP_002047995.1 identified by match to protein family HMM PF02386; match to protein family HMM TIGR00933 YP_002047996.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX YP_002047997.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway YP_002047998.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_002047999.1 identified by match to protein family HMM PF06288 YP_002048000.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_002048001.1 identified by match to protein family HMM PF01323 YP_002048002.1 identified by match to protein family HMM PF01553 YP_002048003.1 identified by glimmer; putative YP_002048004.1 'has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair' YP_002048005.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_002048006.1 identified by match to protein family HMM PF04220 YP_002048007.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002048008.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54 YP_002048009.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation YP_002048010.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme YP_002048011.1 identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394 YP_002048013.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown YP_002048014.1 identified by match to protein family HMM TIGR00792 YP_002048015.1 identified by match to protein family HMM TIGR00792 YP_002048016.1 identified by match to protein family HMM PF01055 YP_002048017.1 identified by match to protein family HMM PF01925 YP_002048018.1 identified by match to protein family HMM PF01263 YP_002048019.1 identified by match to protein family HMM PF07221 YP_002048020.1 identified by match to protein family HMM PF01791 YP_002048021.1 identified by match to protein family HMM PF03446 YP_002048022.1 identified by glimmer; putative YP_002048023.1 identified by match to protein family HMM PF00294 YP_002048024.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279 YP_002048025.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509 YP_002048026.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_002048027.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_002048028.1 identified by match to protein family HMM PF00583; match to protein family HMM PF09500; match to protein family HMM TIGR02447 YP_002048029.1 identified by match to protein family HMM PF01381 YP_002048031.1 identified by match to protein family HMM PF07859 YP_002048034.1 identified by match to protein family HMM PF01381 YP_002048035.1 required for the formation of active formate dehydrogenase YP_002048036.1 cytochrome b556(FDO) component; heme containing YP_002048037.1 identified by match to protein family HMM PF00037; match to protein family HMM PF09163; match to protein family HMM TIGR01582 YP_002048038.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_002048041.1 identified by glimmer; putative YP_002048042.1 identified by match to protein family HMM PF05437 YP_002048043.1 identified by match to protein family HMM PF03591 YP_002048044.1 identified by match to protein family HMM PF01381; match to protein family HMM PF07883 YP_002048045.1 identified by match to protein family HMM PF05336; match to protein family HMM TIGR02625 YP_002048046.1 identified by match to protein family HMM PF00465; match to protein family HMM TIGR02638 YP_002048047.1 identified by match to protein family HMM PF00596; match to protein family HMM TIGR02624 YP_002048048.1 catalyzes the formation of L-rhamnulose from L-rhamnose YP_002048049.1 catalyzes the ATP-dependent phosphorylation of rhamnulose YP_002048050.1 activates the expression of the rhaBAD operon and rhaT gene YP_002048051.1 activates the expression of rhaRS in response to L-rhamnose YP_002048052.1 transports L-rhamnose and L-lyxose into the cell YP_002048054.1 identified by match to protein family HMM PF06178 YP_002048055.1 identified by match to protein family HMM PF06808; match to protein family HMM TIGR00786 YP_002048056.1 identified by match to protein family HMM PF04290 YP_002048057.1 identified by match to protein family HMM PF03480; match to protein family HMM TIGR00787 YP_002048058.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals YP_002048059.1 identified by match to protein family HMM PF03473; match to protein family HMM PF03475 YP_002048061.1 identified by glimmer; putative YP_002048062.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors YP_002048063.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system YP_002048064.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates YP_002048065.1 'member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers' YP_002048066.1 'catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis' YP_002048067.1 identified by match to protein family HMM PF01547; match to protein family HMM TIGR00971 YP_002048068.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00792 YP_002048069.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least YP_002048070.1 identified by match to protein family HMM PF03747 YP_002048071.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702 YP_002048073.1 identified by match to protein family HMM PF07883 YP_002048074.1 identified by match to protein family HMM PF00370; match to protein family HMM PF02782 YP_002048075.1 identified by match to protein family HMM PF04198 YP_002048076.1 identified by match to protein family HMM PF00005 YP_002048077.1 identified by match to protein family HMM PF02653 YP_002048078.1 identified by match to protein family HMM PF02653 YP_002048080.1 identified by match to protein family HMM PF01791 YP_002048081.1 identified by match to protein family HMM PF03992 YP_002048082.1 identified by match to protein family HMM PF00834 YP_002048083.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002048084.1 identified by match to protein family HMM PF07305 YP_002048085.1 identified by match to protein family HMM PF05656 YP_002048086.1 identified by match to protein family HMM PF00175; match to protein family HMM PF00970 YP_002048087.1 'type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese' YP_002048088.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_002048089.1 identified by match to protein family HMM PF00230; match to protein family HMM TIGR00861 YP_002048090.1 identified by match to protein family HMM PF06005 YP_002048091.1 identified by glimmer; putative YP_002048092.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_002048093.1 'catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate' YP_002048094.1 heat shock protein involved in degradation of misfolded proteins YP_002048095.1 heat shock protein involved in degradation of misfolded proteins YP_002048096.1 identified by match to protein family HMM PF05036; match to protein family HMM TIGR02223 YP_002048097.1 'negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins' YP_002048098.1 'binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity' YP_002048099.1 'RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome' YP_002048100.1 identified by match to protein family HMM PF09601; match to protein family HMM TIGR02117 YP_002048101.1 identified by match to protein family HMM PF05935 YP_002048102.1 identified by glimmer; putative YP_002048103.1 identified by glimmer; putative YP_002048104.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_002048105.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_002048106.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_002048107.1 identified by match to protein family HMM PF00924; match to protein family HMM PF05552 YP_002048110.1 identified by match to protein family HMM PF00149; match to protein family HMM PF02872 YP_002048111.1 'MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor' YP_002048112.1 identified by match to protein family HMM PF00141; match to protein family HMM TIGR00198 YP_002048113.1 identified by match to protein family HMM PF06940 YP_002048114.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone YP_002048115.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_002048116.1 identified by match to protein family HMM PF00165 YP_002048117.1 identified by match to protein family HMM PF00884 YP_002048118.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_002048119.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_002048120.1 'catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate' YP_002048121.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_002048122.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_002048123.1 'Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA' YP_002048124.1 catalyzes the conversion of NADPH to NADH YP_002048125.1 identified by match to protein family HMM PF07226 YP_002048126.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_002048127.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space YP_002048128.2 'converts L-glutamate to D-glutamate, a component of peptidoglycan' YP_002048129.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_002048130.1 'catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon' YP_002048131.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_002048133.1 'EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu' YP_002048134.1 'forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force' YP_002048135.1 Modulates Rho-dependent transcription termination YP_002048136.1 binds directly to 23S ribosomal RNA YP_002048137.1 'in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA' YP_002048138.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_002048139.1 'present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors' YP_002048140.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_002048141.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_002048144.1 'in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center' YP_002048145.2 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_002048146.1 'with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate' YP_002048147.1 identified by match to protein family HMM PF00899; match to protein family HMM PF05237 YP_002048148.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate YP_002048149.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_002048150.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_002048151.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_002048152.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_002048153.1 'Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures' YP_002048154.1 identified by match to protein family HMM PF04222 YP_002048155.1 histone-like DNA-binding protein YP_002048156.1 identified by match to protein family HMM PF07356 YP_002048158.1 identified by match to protein family HMM PF00512; match to protein family HMM PF02518 YP_002048159.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein YP_002048160.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_002048161.1 involved in de novo purine biosynthesis YP_002048163.1 identified by glimmer; putative YP_002048164.1 identified by match to protein family HMM PF00583 YP_002048165.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_002048166.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_002048167.1 identified by match to protein family HMM PF00463; match to protein family HMM TIGR01346 YP_002048169.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol YP_002048170.1 identified by match to protein family HMM PF04266 YP_002048171.1 'regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase' YP_002048172.1 identified by glimmer; putative YP_002048173.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_002048174.1 identified by match to protein family HMM PF02690; match to protein family HMM TIGR00704; match to protein family HMM TIGR01013 YP_002048175.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family YP_002048176.1 identified by glimmer; putative YP_002048178.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA YP_002048180.1 identified by match to protein family HMM PF01758 YP_002048185.1 identified by match to protein family HMM PF03406 YP_002048186.1 identified by match to protein family HMM PF09684; match to protein family HMM TIGR01634 YP_002048187.1 identified by match to protein family HMM PF04865 YP_002048188.1 identified by match to protein family HMM PF04965 YP_002048189.1 identified by glimmer; putative YP_002048191.1 identified by match to protein family HMM PF00535 YP_002048192.1 identified by match to protein family HMM PF04138 YP_002048193.1 identified by glimmer; putative YP_002048194.1 identified by match to protein family HMM PF04717; match to protein family HMM TIGR01644 YP_002048195.1 identified by match to protein family HMM PF05954 YP_002048196.1 identified by match to protein family HMM PF05489 YP_002048197.1 identified by match to protein family HMM PF06995 YP_002048198.1 identified by match to protein family HMM TIGR01760 YP_002048201.1 identified by match to protein family HMM PF04985; match to protein family HMM TIGR01611 YP_002048202.1 identified by match to protein family HMM PF04984 YP_002048204.1 identified by match to protein family HMM PF09646 YP_002048206.1 identified by match to protein family HMM PF01464 YP_002048208.1 identified by glimmer; putative YP_002048209.1 identified by glimmer; putative YP_002048210.1 identified by match to protein family HMM PF08765 YP_002048211.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive YP_002048212.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_002048215.1 identified by match to protein family HMM PF06251 YP_002048216.1 identified by match to protein family HMM PF06082 YP_002048217.1 identified by match to protein family HMM PF06146 YP_002048218.1 with MalKFE is involved in the transport of maltose into the cell YP_002048219.1 with MalKGE is involved in maltose transport into the cell YP_002048220.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_002048221.1 with malEFG is involved in import of maltose/maltodextrin YP_002048222.1 porin involved in the transport of maltose and maltodextrins YP_002048223.1 identified by match to protein family HMM PF07148 YP_002048224.1 catalyzes the formation of 4-hydroxybenzoate from chorismate YP_002048225.1 'catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway' YP_002048226.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_002048227.1 identified by match to protein family HMM PF01219 YP_002048228.1 Represses a number of genes involved in the response to DNA damage YP_002048229.1 identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797 YP_002048231.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential YP_002048232.1 'Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB' YP_002048234.1 identified by match to protein family HMM PF01207; match to protein family HMM TIGR00742 YP_002048235.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240 YP_002048236.1 unwinds double stranded DNA YP_002048237.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_002048238.1 identified by glimmer; putative YP_002048239.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_002048240.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity YP_002048241.1 identified by match to protein family HMM PF01894; match to protein family HMM TIGR00149 YP_002048242.1 identified by match to protein family HMM PF04237 YP_002048245.1 'The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate' YP_002048246.1 binds to single stranded DNA and PriA helcase facilitate replication restart YP_002048247.1 identified by glimmer; putative YP_002048248.1 identified by glimmer; putative YP_002048251.1 identified by match to protein family HMM PF02321 YP_002048254.1 identified by match to protein family HMM PF00005 YP_002048255.1 identified by match to protein family HMM PF00563 YP_002048256.1 regulates genes involved in response to oxidative stress YP_002048257.1 identified by match to protein family HMM PF00376; match to protein family HMM PF09278; match to protein family HMM TIGR01950 YP_002048258.1 identified by match to protein family HMM PF00043; match to protein family HMM PF02798 YP_002048259.1 identified by match to protein family HMM PF00860; match to protein family HMM PF00916 YP_002048260.1 identified by match to protein family HMM PF00999; match to protein family HMM TIGR00831 YP_002048261.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002048262.2 identified by match to protein family HMM PF03788 YP_002048263.1 identified by match to protein family HMM PF04172 YP_002048264.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake YP_002048265.1 identified by match to protein family HMM PF04341 YP_002048266.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_002048267.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 YP_002048268.1 'part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia' YP_002048269.1 identified by match to protein family HMM PF00037; match to protein family HMM TIGR01409; match to protein family HMM TIGR03149 YP_002048270.1 identified by match to protein family HMM PF03916; match to protein family HMM TIGR03148 YP_002048271.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552 YP_002048272.1 identified by match to protein family HMM PF03918; match to protein family HMM TIGR03147 YP_002048273.1 identified by match to protein family HMM PF07719 YP_002048275.1 'carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system' YP_002048276.1 identified by match to protein family HMM PF08238 YP_002048277.1 identified by match to protein family HMM PF05118 YP_002048278.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role YP_002048279.1 identified by match to protein family HMM PF00903; match to protein family HMM PF06983 YP_002048280.1 identified by match to protein family HMM PF03831; match to protein family HMM PF08274; match to protein family HMM TIGR00686 YP_002048281.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690; match to protein family HMM PF08946; match to protein family HMM TIGR00883 YP_002048282.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518 YP_002048283.1 response regulator in two-component regulatory system with BasS YP_002048284.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division YP_002048285.1 identified by match to protein family HMM PF00324 YP_002048286.1 identified by match to protein family HMM PF00165 YP_002048287.1 identified by match to protein family HMM PF01276; match to protein family HMM PF03709; match to protein family HMM PF03711 YP_002048288.1 identified by match to protein family HMM PF00165 YP_002048289.1 identified by match to protein family HMM PF02056 YP_002048290.1 identified by match to protein family HMM TIGR00792 YP_002048291.1 identified by match to protein family HMM PF05681; match to protein family HMM PF05683; match to protein family HMM TIGR00722; match to protein family HMM TIGR00723 YP_002048292.1 'functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters' YP_002048294.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration YP_002048295.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration YP_002048296.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR02166 YP_002048297.1 identified by match to protein family HMM PF00037; match to protein family HMM TIGR02951 YP_002048298.1 identified by match to protein family HMM PF04976 YP_002048300.1 identified by match to protein family HMM PF06977 YP_002048302.1 identified by match to protein family HMM PF00196 YP_002048303.1 identified by match to protein family HMM PF00165 YP_002048306.1 identified by match to protein family HMM PF06717 YP_002048307.1 identified by match to protein family HMM PF01569 YP_002048309.1 identified by match to protein family HMM PF03693; match to protein family HMM TIGR02606 YP_002048311.1 identified by match to protein family HMM PF06117 YP_002048313.1 identified by match to protein family HMM PF06755 YP_002048314.1 identified by match to protein family HMM PF06154 YP_002048316.1 identified by match to protein family HMM PF06174 YP_002048317.1 identified by match to protein family HMM PF04002; match to protein family HMM TIGR00608 YP_002048318.1 identified by match to protein family HMM PF03230 YP_002048319.1 identified by match to protein family HMM PF06067 YP_002048321.1 identified by match to protein family HMM PF01926 YP_002048324.1 identified by glimmer; putative YP_002048328.1 identified by glimmer; putative YP_002048329.1 identified by match to protein family HMM PF05930 YP_002048332.1 identified by glimmer; putative YP_002048334.1 identified by glimmer; putative YP_002048335.1 identified by glimmer; putative YP_002048336.1 identified by match to protein family HMM PF00816 YP_002048337.1 identified by glimmer; putative YP_002048339.1 identified by match to protein family HMM PF01966; match to protein family HMM TIGR01353 YP_002048340.1 identified by match to protein family HMM PF00665 YP_002048341.1 identified by match to protein family HMM PF00303 YP_002048342.1 identified by match to protein family HMM PF01609 YP_002048344.1 identified by match to protein family HMM PF01381; match to protein family HMM PF06114 YP_002048346.1 identified by match to protein family HMM PF00270; match to protein family HMM PF04313; match to protein family HMM PF04851 YP_002048347.1 identified by match to protein family HMM PF02384 YP_002048348.1 identified by match to protein family HMM PF01420 YP_002048350.1 identified by match to protein family HMM PF01609 YP_002048351.1 identified by match to protein family HMM PF03616; match to protein family HMM TIGR00210 YP_002048352.1 identified by glimmer; putative YP_002048354.1 identified by match to protein family HMM PF01527 YP_002048356.1 identified by match to protein family HMM PF07690 YP_002048358.1 identified by match to protein family HMM PF01609 YP_002048364.1 identified by glimmer; putative YP_002048365.1 identified by glimmer; putative YP_002048366.1 identified by glimmer; putative YP_002048367.1 identified by match to protein family HMM PF00884 YP_002048369.1 identified by match to protein family HMM PF00589 YP_002048370.1 identified by match to protein family HMM PF00440 YP_002048371.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_002048372.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals YP_002048373.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_002048374.1 catalyzes the formation of fumarate from aspartate YP_002048375.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_002048376.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function YP_002048377.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_002048378.1 '60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth' YP_002048381.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR00238 YP_002048382.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_002048383.1 identified by match to protein family HMM PF08085 YP_002048385.1 lipocalin; globomycin-sensitive outer membrane lipoprotein YP_002048386.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane YP_002048387.1 'part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB' YP_002048388.1 'part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB' YP_002048389.1 'part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB' YP_002048390.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002048391.1 identified by match to protein family HMM PF00324 YP_002048393.1 identified by match to protein family HMM PF00924 YP_002048394.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_002048395.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_002048396.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_002048397.1 identified by match to protein family HMM PF00497 YP_002048398.1 identified by match to protein family HMM PF08331; match to protein family HMM TIGR00276 YP_002048399.1 identified by match to protein family HMM PF01256; match to protein family HMM PF03853; match to protein family HMM TIGR00196; match to protein family HMM TIGR00197 YP_002048400.1 possibly involved in cell wall synthesis YP_002048401.1 identified by match to protein family HMM PF01520 YP_002048402.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_002048403.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_002048404.1 Stimulates the elongation of poly(A) tails YP_002048405.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein YP_002048406.1 with HflC inhibits proteolysis of lambda cII protein by FtsH YP_002048407.1 with HflK inhibits proteolysis of lambda cII protein by FtsH YP_002048409.1 'catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis' YP_002048410.1 negatively regulates the transcription of genes upregulated by nitrosative stress YP_002048411.1 '3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs' YP_002048412.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_002048414.1 identified by match to protein family HMM PF04012 YP_002048416.1 identified by match to protein family HMM PF03994 YP_002048417.1 identified by match to protein family HMM PF06693 YP_002048418.1 identified by match to protein family HMM PF03738 YP_002048419.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA YP_002048420.1 identified by match to protein family HMM PF07338 YP_002048421.1 'in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility' YP_002048422.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo YP_002048423.1 negative regulator of ulaG and ulaABCDEF YP_002048425.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_002048426.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002048427.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002048428.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_002048429.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway YP_002048430.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_002048431.1 identified by glimmer; putative YP_002048432.1 identified by glimmer; putative YP_002048433.1 'binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21' YP_002048434.1 binds single-stranded DNA at the primosome assembly site YP_002048435.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_002048436.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_002048437.1 identified by match to protein family HMM PF00892 YP_002048438.1 identified by match to protein family HMM PF04225; match to protein family HMM PF08525 YP_002048439.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides YP_002048440.1 'involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine' YP_002048441.1 Involved in anaerobic NO protection and iron metabolism YP_002048442.1 identified by match to protein family HMM PF00892 YP_002048443.1 identified by match to protein family HMM PF01073; match to protein family HMM PF02254; match to protein family HMM PF05368; match to protein family HMM PF07993 YP_002048444.1 'periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate' YP_002048445.1 identified by glimmer; putative YP_002048446.1 'catalyzes the formation of AMP from adenosine-3',5'-bisphosphate' YP_002048447.1 identified by match to protein family HMM PF09695; match to protein family HMM TIGR01626 YP_002048448.1 identified by match to protein family HMM PF06526 YP_002048449.1 identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471 YP_002048450.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002048451.1 identified by glimmer; putative YP_002048452.1 identified by match to protein family HMM PF01103; match to protein family HMM PF07244 YP_002048453.1 identified by match to protein family HMM PF04357 YP_002048454.1 identified by match to protein family HMM PF06094 YP_002048455.1 identified by match to protein family HMM PF07690 YP_002048456.1 identified by match to protein family HMM PF01979 YP_002048457.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_002048458.1 'catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate' YP_002048459.1 identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01081 YP_002048460.1 identified by match to protein family HMM PF04751 YP_002048461.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD YP_002048462.1 identified by match to protein family HMM PF07361 YP_002048463.1 identified by match to protein family HMM PF00874; match to protein family HMM TIGR03582 YP_002048464.1 identified by match to protein family HMM TIGR03577 YP_002048465.1 identified by match to protein family HMM TIGR03578 YP_002048466.1 identified by match to protein family HMM TIGR03580 YP_002048467.1 identified by match to protein family HMM TIGR03579 YP_002048468.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides YP_002048469.1 identified by match to protein family HMM PF01212; match to protein family HMM PF03841; match to protein family HMM TIGR01437 YP_002048470.1 identified by match to protein family HMM PF07071; match to protein family HMM TIGR03581 YP_002048471.1 identified by match to protein family HMM PF00359; match to protein family HMM PF00874; match to protein family HMM PF05043; match to protein family HMM PF08279 YP_002048472.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor YP_002048473.1 identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385 YP_002048474.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions YP_002048475.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_002048477.1 identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403 YP_002048478.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002048479.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon YP_002048480.1 P-type ATPase involved in magnesium influx YP_002048481.1 identified by match to protein family HMM PF01527 YP_002048482.1 identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004 YP_002048483.1 involved in the allosteric regulation of aspartate carbamoyltransferase YP_002048484.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_002048485.1 identified by match to protein family HMM PF01316; match to protein family HMM PF02863 YP_002048486.1 identified by glimmer; putative YP_002048487.1 identified by match to protein family HMM PF03606 YP_002048488.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_002048489.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_002048490.1 catalyzes the degradation of arginine to citruline and ammonia YP_002048491.1 identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022 YP_002048492.1 'catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.' YP_002048493.1 identified by match to protein family HMM PF06877 YP_002048494.1 identified by match to protein family HMM PF01797 YP_002048495.1 identified by match to protein family HMM PF06175 YP_002048497.1 identified by match to protein family HMM PF00583 YP_002048498.1 identified by match to protein family HMM PF05987 YP_002048499.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_002048500.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_002048501.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_002048502.1 identified by match to protein family HMM PF03739 YP_002048503.1 identified by match to protein family HMM PF03739 YP_002048504.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532 YP_002048505.1 identified by match to protein family HMM PF02447; match to protein family HMM PF03600; match to protein family HMM PF06808; match to protein family HMM TIGR00791 YP_002048506.1 'Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate' YP_002048507.1 NAD-binding YP_002048508.1 identified by match to protein family HMM PF01202; match to protein family HMM TIGR01313 YP_002048509.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240 YP_002048512.1 identified by match to protein family HMM PF00176; match to protein family HMM PF00271 YP_002048514.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF09369 YP_002048515.1 identified by match to protein family HMM PF00580 YP_002048516.1 identified by match to protein family HMM PF00903 YP_002048518.1 identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033 YP_002048519.1 identified by match to protein family HMM PF02353; match to protein family HMM PF07021; match to protein family HMM PF08241; match to protein family HMM PF08242 YP_002048521.2 identified by match to protein family HMM PF06353 YP_002048524.1 identified by glimmer; putative YP_002048525.1 identified by glimmer; putative YP_002048526.1 identified by match to protein family HMM PF03625 YP_002048527.1 identified by match to protein family HMM PF01738 YP_002048528.1 regulates the expression of uxuBA YP_002048529.1 'catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA' YP_002048530.2 identified by match to protein family HMM PF05638 YP_002048531.1 identified by match to protein family HMM PF01177; match to protein family HMM TIGR00035 YP_002048532.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_002048533.1 identified by match to protein family HMM PF01979; match to protein family HMM PF07969; match to protein family HMM TIGR01975 YP_002048534.1 identified by match to protein family HMM PF07670 YP_002048535.1 identified by match to protein family HMM PF07670 YP_002048536.1 identified by glimmer; putative YP_002048537.1 identified by match to protein family HMM PF06779; match to protein family HMM PF07690 YP_002048538.1 identified by match to protein family HMM PF04286 YP_002048539.1 identified by match to protein family HMM PF07690 YP_002048540.1 identified by glimmer; putative YP_002048542.1 identified by glimmer; putative YP_002048543.1 identified by match to protein family HMM PF00171 YP_002048544.1 identified by match to protein family HMM PF06568 YP_002048546.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response YP_002048547.1 identified by match to protein family HMM PF01420 YP_002048548.1 identified by match to protein family HMM PF02384 YP_002048549.1 restriction endonuclease; the EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'; subunit R is required for both nuclease and ATPase activities YP_002048550.1 identified by match to protein family HMM PF04471 YP_002048551.1 identified by match to protein family HMM PF04365 YP_002048553.1 identified by match to protein family HMM PF02492; match to protein family HMM PF07683 YP_002048554.1 identified by match to protein family HMM PF04328 YP_002048555.1 identified by match to protein family HMM PF02554 YP_002048556.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02203 YP_002048558.1 identified by match to protein family HMM PF03610 YP_002048559.1 identified by match to protein family HMM PF03830 YP_002048560.1 identified by match to protein family HMM PF03609 YP_002048561.1 identified by match to protein family HMM PF03613 YP_002048562.1 identified by match to protein family HMM PF01380 YP_002048563.1 identified by match to protein family HMM PF01380 YP_002048564.1 catalyzes the transfer of phosphoglycerol to the glucan backbone YP_002048566.1 acts to load the DnaB helicase onto the initiation site during DNA replication YP_002048567.1 'This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'' YP_002048569.1 identified by match to protein family HMM PF06738 YP_002048570.1 identified by match to protein family HMM PF00196 YP_002048571.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin YP_002048572.1 identified by match to protein family HMM PF04073 YP_002048573.1 involved in ferric hydroximate transport; identified by match to protein family HMM PF06276 YP_002048574.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254 YP_002048575.1 identified by match to protein family HMM PF07256 YP_002048576.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit YP_002048577.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_002048578.2 identified by match to protein family HMM PF00583; match to protein family HMM TIGR01575 YP_002048579.1 'manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily' YP_002048580.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_002048581.1 identified by match to protein family HMM PF04972 YP_002048582.1 identified by glimmer; putative YP_002048583.1 identified by match to protein family HMM PF01734 YP_002048584.1 identified by match to protein family HMM PF01026 YP_002048585.1 identified by match to protein family HMM PF00037; match to protein family HMM PF04055 YP_002048587.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_002048588.1 'Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate' YP_002048589.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_002048590.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_002048592.1 identified by match to protein family HMM PF00577 YP_002048593.1 member of the periplasmic pilus chaperone family of proteins YP_002048594.1 identified by match to protein family HMM PF06551 YP_002048595.1 identified by match to protein family HMM PF06551 YP_002048596.1 identified by glimmer; putative YP_002048597.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins YP_002048599.1 catalyzes the formation of serine from O-phosphoserine YP_002048600.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_002048601.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_002048602.1 'ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence' YP_002048603.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan YP_002048604.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription YP_002048605.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog YP_002048606.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate YP_002048607.1 identified by match to protein family HMM PF00165; match to protein family HMM PF06445 YP_002048608.1 identified by match to protein family HMM PF05981 YP_002048609.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation YP_002048610.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation YP_002048611.1 identified by match to protein family HMM PF06123 YP_002048612.1 identified by match to protein family HMM PF00419 YP_002048613.1 identified by match to protein family HMM PF00419 YP_002048614.2 identified by match to protein family HMM PF00577 YP_002048615.1 identified by match to protein family HMM PF00345; match to protein family HMM PF02753 YP_002048616.1 identified by match to protein family HMM PF00419 YP_002048618.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_002048619.1 member of the SPOUT superfamily of methyltransferases