-- dump date   	20140620_043546
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_209256.1	IPR000847: bacterial regulatory protein LysR
YP_209257.1	M3 in mba region; IPR003518: Salmonella virulence plasmid 28.1 kDa A protein
YP_209258.1	IPR003284: Salmonella virulence plasmid 65 kDa B protein
YP_209259.1	IPR003519: Salmonella virulence-associated 28 kDa protein
YP_209260.1	IPR008834: Salmonella plasmid virulence SpvD
YP_209261.1	IPR002686: transposase IS200-like
YP_209263.1	IPR003535: intimin bacterial adhesion mediator protein
YP_209264.1	IPR002482: peptidoglycan-binding LysM
YP_209267.1	IPR001633: EAL domain
YP_209268.1	protein D; IPR002104: phage integrase
YP_209271.1	LetB protein; protein G; controlled cell death protein; post-segregation toxin; toxin addiction system
YP_209272.1	LetA protein; protein H; LynA
YP_209274.1	IPR000525: initiator RepB protein; IPR002584: RepA protein
YP_209275.1	afa region
YP_209276.1	IPR005220: conserved hypothetical protein 156
YP_209277.1	IPR004356: P pili regulatory PapB protein
YP_209278.1	IPR000259: fimbrial protein
YP_209279.1	IPR000015: fimbrial biogenesis outer membrane usher protein
YP_209280.1	IPR001829: bacterial pili assembly chaperone
YP_209281.2	RepA
YP_209282.1	acts to regulate the expression of the plasmid replication protein RepA in the IncFII plasmid group
YP_209284.1	conjugal transfer protein; IPR007950: fertility inhibition
YP_209285.1	IPR008875: TraX
YP_209286.1	DNA helicase I
YP_209287.1	DNA helicase I
YP_209289.1	type IV secretion system coupling protein; similar to F plasmid TraD
YP_209290.1	IPR008874: enterobacterial TraT complement resistance
YP_209292.1	IPR006197: peptidase S24: IPR006198: peptidase S24
YP_209293.1	binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization
YP_209294.1	IPR003115: ParB-like nuclease: IPR004437: ParB-like partition protein
YP_209295.1	IPR006095: Glu/Leu/Phe/Val dehydrogenase
YP_209296.1	IPR006842: putative transposase YhgA-like
YP_209302.1	IPR001765: prokaryotic carbonic anhydrase: IPR006311: twin-arginine translocation pathway signal
YP_209303.1	IPR006118: site-specific recombinase; IPR006119: resolvase, N-terminal
YP_209304.1	IPR001584: integrase catalytic domain
YP_209305.1	IPR003593: AAA ATPase
YP_209308.1	IPR000620: protein of unknown function DUF6
YP_209309.1	IPR001958: tetracycline resistance protein; IPR004734: multidrug resistance protein; IPR005828: general substrate transporter; IPR005829: sugar transporter superfamily; IPR007114: major facilitator superfamily
YP_209310.1	IPR001137: glycoside hydrolase family 11; IPR001647: bacterial regulatory protein TetR (HTH motif); IPR003012: tetracycline repressor protein; IPR004111: tetracycline repressor
YP_209312.1	IPR002513: transposase Tn3
YP_209313.1	IPR002513: transposase Tn3
YP_209314.1	IPR006120: resolvase helix-turn-helix domain
YP_209315.1	drug-resistance protein
YP_209316.1	CAT-II; IPR001707: chloramphenicol acetyl transferase
YP_209318.1	IPR001584: integrase catalytic domain
YP_209319.1	IPR002513: transposase Tn3
YP_209320.1	IPR006118: site-specific recombinase; IPR006119: resolvase, N-terminal; IPR006120: resolvase helix-turn-helix domain
YP_209321.1	IPR001584: integrase catalytic domain
YP_209322.1	IPR000209: peptidase S8 subtilase serine protease; IPR006118: site-specific recombinase; IPR006119: resolvase, N-terminal; IPR006120: resolvase helix-turn-helix domain
YP_209323.1	IPR000871: Beta-lactamase, class A; IPR001466: Beta-lactamase
YP_209324.1	drug-resistance protein
YP_209325.1	IPR000103: pyridine nucleotide-disulphide oxidoreductase, class-II; IPR000815: mercuric reductase; IPR001100: pyridine nucleotide-disulphide oxidoreductase, class I; IPR001327: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; IPR004099: pyridine nucleotide-disulphide oxidoreductase dimerisation domain; IPR006121: heavy metal transport/detoxification protein; IPR006191: heavy metal binding; drug-resistance protein
YP_209326.1	IPR000551: bacterial regulatory protein, MerR family; drug-resistance protein
YP_209327.1	IPR007746: MerE
YP_209328.1	IPR001633: EAL domain
YP_209329.1	IPR001584: integrase catalytic domain
YP_209330.1	IPR001584: integrase catalytic domain; drug-resistance protein
YP_209331.1	IPR002575: aminoglycoside phosphotransferase; IPR008266: tyrosine protein kinase, active site
YP_209332.1	IPR001584: integrase catalytic domain
YP_209334.1	IPR002104: phage integrase; IPR004107: phage integrase, N-terminal SAM-like; drug-resistance protein
YP_209335.1	IPR001796: dihydrofolate reductase
YP_209337.1	streptomycin 3'-adenyltransferase
YP_209338.1	IPR000390: small multidrug resistance protein; drug-resistance protein
YP_209339.1	IPR000489: dihydropteroate synthase, DHPS; IPR006390: dihydropteroate synthase; drug-resistance protein
YP_209340.1	IPR000182: GCN5-related N-acetyltransferase; similar to gp:TTU42226_2
YP_209341.1	IPR008868: bacterial TniB
YP_209343.1	IPR001584: integrase catalytic domain
YP_209344.1	IPR001789: response regulator receiver; IPR003594: ATP-binding region, ATPase-like; IPR003661: histidine kinase A, N-terminal; IPR004358: bacterial sensor protein, C-terminal; IPR005467: histidine kinase
YP_209347.1	IPR001789: response regulator receiver; drug-resistance protein
YP_209349.1	IPR001584: integrase catalytic domain; drug-resistance protein
YP_209351.1	IPR002198: short-chain dehydrogenase/reductase SDR; IPR002347: glucose/ribitol dehydrogenase; IPR003560: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
YP_209352.1	drug-resistance protein
YP_209353.1	IPR000489: dihydropteroate synthase, DHPS; IPR006390: dihydropteroate synthase
YP_209354.1	IPR001207: transposase, mutator family; similar to Pseudomonas cepacia insertion sequence IS406 and IS407 hypothetical protein 1 (S28978) and Burkholderia cepacia insertion sequence IS406 ORF1 (AAA25037)
YP_209355.1	IPR000390: small multidrug resistance protein; drug-resistance protein
YP_209356.1	streptomycin 3'-adenyltransferase
YP_209357.1	IPR001411: tetracycline resistance protein TetB; IPR001958: tetracycline resistance protein; IPR004734: multidrug resistance protein; IPR004812: drug resistance transporter Bcr/CflA subfamily; IPR005828: general substrate transporter; IPR007114: major facilitator superfamily; similar to Pseudomonas aeruginosa chloramphenicol resistance protein CmlA (A47033) and P. aeruginosa nonenzymatic chloramphenicol-resistance protein (AAA26057)
YP_209358.2	streptomycin 3'-adenyltransferase
YP_209359.1	IPR005834: haloacid dehalogenase-like hydrolase; IPR006383: HAD-superfamily hydrolase, subfamily IB (PSPase-like); IPR006385: HAD-superfamily subfamily IB hydrolase, hypothetical 2
YP_209360.1	IPR000073: alpha/beta hydrolase fold; IPR000379: esterase/lipase/thioesterase; IPR003089: alpha/beta hydrolase
YP_209361.1	IPR002104: phage integrase; IPR004107: phage integrase, N-terminal SAM-like; drug-resistance protein
YP_209362.1	IPR001633: EAL domain
YP_209363.1	IPR001584: integrase catalytic domain
YP_209365.1	IPR006118: site-specific recombinase; IPR006119: resolvase, N-terminal; IPR006120: resolvase helix-turn-helix domain
YP_209367.1	IPR003220: insertion element protein
YP_209368.1	IPR005063: transposase
YP_209369.1	drug-resistance protein
YP_209370.1	IPR002575: aminoglycoside phosphotransferase
YP_209371.1	IPR001584: integrase catalytic domain
YP_209372.1	similar to plasmid R64 TraQ
YP_209373.1	similar to plasmid R64 TraP
YP_209374.1	similar to plasmid R64 TraO
YP_209375.1	similar to plasmid R64 TraN
YP_209376.1	similar to plasmid R64 TraM
YP_209377.1	similar to plasmid R64 TraL
YP_209379.1	IPR001584: integrase catalytic domain
YP_209380.1	similar to plasmid R64 TraU
YP_209381.1	similar to plasmid R64 TraV
YP_209383.1	similar to plasmid R64 TraX
YP_209393.1	IPR002559: transposase IS4; drug-resistance protein
YP_209394.2	IPR001466: beta-lactamase; IPR001586: beta-lactamase, class C active site
YP_209395.1	lipocalin; globomycin-sensitive outer membrane lipoprotein
YP_209396.1	IPR000390: small multidrug resistance protein
YP_209398.1	similar to TrbA deposited in GenBank Accession Number BAA75143
YP_209399.1	IPR006663: thioredoxin domain 2; similar to gp:STYINCI1PR_4,prf:2209346D
YP_209400.1	similar to TrbC deposited in GenBank Accession Number BAA75141
YP_209402.1	similar to relaxase (NikB) deposited in GenBank Accession Number BAA75140
YP_209404.1	similar to YggA deposited in GenBank Accession Number BAB91642
YP_209410.1	IPR006842: similar to sp:YTL2_SALTY
YP_209416.1	similar to pir:T13129
YP_209417.1	PsiA
YP_209419.2	IPR003115: ParB-like nuclease; IPR004437: ParB-like partition protein; similar to gp:RMPGR4A_1,prf:2006305A
YP_209420.1	similar to gp:AF074613_85
YP_209421.1	IPR000424: Single-Strand binding protein
YP_209425.1	orf63
YP_209427.1	IPR004914: antirestriction protein
YP_209428.1	similar to gp:AB021078_36
YP_209429.1	similar to gp:AB011549_40
YP_209430.1	similar to gp:AF106329_5
YP_209431.1	IPR001091: Site-specific DNA-methyl transferase (cytosine-N4-specific); IPR002052: N-6 Adenine-specific DNA methylase; IPR002295: N6 adenine-specific DNA methyl transferase, D21 class; IPR002941: DNA methylase N-4/N-6; similar to gp:ECU48806_2
YP_209437.1	IPR006197: Peptidase S24; IPR006198: Peptidase S24, C-terminal; similar to IMPA_SALTY,sp:18641
YP_209438.1	IPR002104: phage integrase
YP_209439.1	IPR002104: phage integrase
YP_209441.1	IPR002104: phage integrase
YP_209446.1	IPR006442: Prevent-host-death family protein
YP_209450.1	SopB
YP_209451.1	IPR000525: initiator RepB protein; IPR002584: RepA protein
YP_209453.1	IPR000566: Lipocalin-related protein and Bos/Can/Equ allergen; IPR001064: beta and gamma crystallin; IPR002446: Bacterial lipocalin
YP_209454.1	IPR000551: bacterial regulatory protein, MerR family
YP_209455.1	IPR000895: Transthyretin
YP_209456.1	IPR007553: Protein of unknown function DUF523
YP_209457.1	IPR003439: ABC transporter
YP_209458.1	IPR001584: integrase catalytic domain
YP_209460.1	IPR000345: Cytochrome c heme-binding site
YP_209462.1	Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor
YP_209465.1	IPR001270: Chaperonin clpA/B; IPR002611: IstB-like ATP-binding protein; IPR003593: AAA ATPase
YP_209466.1	IPR000792: Bacterial regulatory protein, LuxR family; IPR001584: integrase catalytic domain; IPR002197: Helix-turn-helix, Fis-type; IPR007101: IS21-like element transposase, HTH domain
YP_209467.1	IPR002078: Sigma-54 factor interaction domain
YP_209470.1	IPR001584: integrase catalytic domain
YP_209471.1	IPR002514: transposase, IS3/IS911family
YP_209473.1	IPR002104: phage integrase; IPR004107: Phage integrase, N-terminal SAM-like
YP_209474.1	IPR005063: IS1 transposase
YP_209475.1	IPR002513: transposase Tn3
YP_214989.1	multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_214990.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_214991.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_214992.1	IPR001064: Beta and gamma crystallin
YP_214993.1	IPR000005: Helix-turn-helix, AraC type; IPR001463: Sodium:alanine symporter; IPR002293: Amino acid/polyamine transporter family I
YP_214994.2	Maintains the balance of metabolites in the pentose-phosphate pathway
YP_214995.1	forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis
YP_214996.1	IPR000791: GPR1/FUN34/yaaH family
YP_214999.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_215000.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_215008.1	IPR001525: C-5 cytosine-specific DNA methylase; IPR001829: Bacterial pili assembly chaperone
YP_215012.1	IPR001829: Bacterial pili assembly chaperone
YP_215013.1	IPR006663: Thioredoxin domain 2
YP_215021.1	exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH
YP_215022.1	Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC
YP_215024.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_215026.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_215027.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme
YP_215028.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_215029.1	IPR001179: Peptidylprolyl isomerase, FKBP-type
YP_215030.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_215032.1	catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides
YP_215033.1	IPR001789: Response regulator receiver
YP_215034.1	IPR004358: Bacterial sensor protein, C-terminal; IPR005467: Histidine kinase
YP_215036.1	catalyzes the formation of pyruvate from oxaloacetate
YP_215037.1	catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide
YP_215038.1	IPR004679: Citrate carrier protein
YP_215040.1	acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate
YP_215042.1	bifunctional
YP_215045.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_215047.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_215048.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_215049.1	regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons
YP_215050.1	involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities
YP_215051.1	catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA
YP_215052.1	IPR000873: AMP-dependent synthetase and ligase
YP_215053.1	catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine
YP_215054.1	catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA
YP_215055.1	catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism
YP_215057.1	required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase
YP_215058.1	involved in electron transfer during carnitine metabolism
YP_215059.1	FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction
YP_215061.1	IPR003663: Sugar transporter; IPR005828: General substrate transporter; IPR007114: Major facilitator superfamily
YP_215067.1	Required for full activity of KefC, a potassium-proton antiporter
YP_215068.1	transport system that facilitates potassium-efflux
YP_215069.1	catalyzes the reduction of dihydrofolate to tetrahydrofolate
YP_215070.1	hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP
YP_215071.1	protein associated with Co2+ and Mg2+ efflux
YP_215072.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_215073.1	catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate)
YP_215074.1	Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB
YP_215075.1	determines N-hexane tolerance and is involved in outer membrane permeability
YP_215076.1	functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system
YP_215077.1	catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs
YP_215078.1	transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA
YP_215079.1	Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C
YP_215082.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_215083.1	catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism
YP_215085.1	positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose
YP_215087.1	with TbpA and ThiP is part of the thiamine and TPP transport system
YP_215088.1	permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine
YP_215089.1	part of the thiamine and TPP transport system tbpA-thiPQ
YP_215090.1	activates sgrS under glucose-phosphate stress conditions
YP_215093.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_215094.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_215095.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_215096.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_215097.1	involved in attenuation control of the leuABCD operon in leucine biosynthesis
YP_215100.2	catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive
YP_215101.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_215102.1	binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism
YP_215103.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_215104.1	IPR002903: Bacterial methyltransferase
YP_215105.1	membrane bound cell division protein at septum containing leucine zipper motif
YP_215107.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_215109.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_215110.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_215111.1	integral membrane protein involved in stabilizing FstZ ring during cell division
YP_215112.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_215113.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_215114.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_215115.1	involved in septum formation
YP_215116.1	ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane
YP_215117.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_215118.1	zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis
YP_215119.1	secM translational pause allows for the initiation of secA translation
YP_215120.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_215121.1	IPR000086: NUDIX hydrolase; IPR003561: Mutator MutT
YP_215122.1	IPR001395: Aldo/keto reductase
YP_215123.1	IPR000847: Bacterial regulatory protein LysR, HTH motif; IPR005119: LysR substrate binding domain
YP_215126.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_215127.1	catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate
YP_215128.1	IPR003004: Bacterial general secretion pathway protein F
YP_215129.1	IPR001482: Bacterial type II secretion system protein E
YP_215130.1	IPR001082: Fimbrial protein pilin; IPR001120: Prokaryotic N-terminal methylation site
YP_215131.2	catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide
YP_215133.1	involved in regulation of beta-lactamase; signaling protein
YP_215135.1	IPR001092: Basic helix-loop-helix dimerization domain bHLH
YP_215136.1	IPR002293: Amino acid/polyamine transporter family I; IPR004840: Amino acid permease
YP_215137.1	activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex
YP_215138.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_215139.1	Catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA
YP_215140.1	E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_215144.1	catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate
YP_215145.1	might be involved in hypersensitivity to nitrofurzone
YP_215148.1	transports degraded pectin products into the bacterial cell
YP_215150.1	catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate)
YP_215151.1	IPR001034: Bacterial regulatory protein, DeoR family
YP_215152.1	S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine
YP_215153.1	catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_215155.1	laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification
YP_215156.1	IPR001479: Bacterial quinoprotein dehydrogenase
YP_215157.2	Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively
YP_215158.2	catalyzes the interconversion of bicarbonate and carbon dioxide
YP_215159.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_215160.1	IPR000412: ABC transporter family 2
YP_215161.1	IPR000259: Fimbrial protein
YP_215163.1	IPR001829: Bacterial pili assembly chaperone
YP_215167.1	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5)
YP_215168.1	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine
YP_215169.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_215170.1	catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP
YP_215171.1	Polymerase that creates the 3' poly(A) tail found in some mRNA's
YP_215172.2	this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu
YP_215173.2	IPR000962: Zn-finger, prokaryotic DksA/TraR C4 type
YP_215174.1	Regulatory factor involved in maltose metabolism
YP_215176.1	similar in sequence to the ATP-dependent RNA helicase HrpA
YP_215177.1	bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell
YP_215178.1	involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein
YP_215179.2	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter
YP_215180.1	Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores
YP_215181.1	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome
YP_215183.1	IPR000015: Fimbrial biogenesis outer membrane usher protein; IPR002092: DNA-directed RNA polymerase, bacteriophage type
YP_215184.1	IPR001829: Bacterial pili assembly chaperone
YP_215186.1	IPR000259: Fimbrial protein
YP_215189.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_215190.1	Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation
YP_215191.1	essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors
YP_215193.1	solute binding component of the vitamin B12 transport system BtuCDF
YP_215194.1	enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine
YP_215195.1	forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate
YP_215196.1	protease Do; required at high temperature; degrades damaged proteins
YP_215197.1	regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization
YP_215199.1	IPR007114: Major facilitator superfamily
YP_215200.1	catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway
YP_215201.1	catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein
YP_215202.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_215203.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_215204.2	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_215205.1	Catalyzes the phosphorylation of UMP to UDP
YP_215206.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_215207.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_215208.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_215209.2	catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate
YP_215210.1	catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response
YP_215211.1	part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins
YP_215212.1	IPR005632: Outer membrane protein (OmpH-like)
YP_215213.1	adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
YP_215214.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_215215.1	catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis
YP_215216.1	catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM
YP_215217.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_215218.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_215219.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein
YP_215220.1	IPR000726: Glycoside hydrolase, family 19
YP_215221.1	IPR000310: Orn/Lys/Arg decarboxylase, major region
YP_215222.1	IPR004361: Glyoxalase I
YP_215223.1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase
YP_215224.1	Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination
YP_215227.1	IPR000352: Class I peptide chain release factor domain
YP_215228.2	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_215229.1	IPR001378: Protein of unknown function, UPF0066
YP_215232.1	part of the MetNIQ methionine uptake system
YP_215233.2	part of the metNIQ transport system for methionine
YP_215234.1	Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate
YP_215238.1	catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid
YP_215239.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_215240.1	IPR007114: Major facilitator superfamily
YP_215242.1	IPR000051: SAM (and some other nucleotide) binding motif; IPR001601: Generic methyltransferase
YP_215243.1	catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall
YP_215244.1	catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione
YP_215246.2	An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
YP_215247.1	3'-5' exonuclease of DNA polymerase III
YP_215262.1	IPR006665: OmpA/MotB domain
YP_215271.1	IPR001826: RHS protein
YP_215280.1	IPR001829: Bacterial pili assembly chaperone
YP_215281.1	IPR000015: Fimbrial biogenesis outer membrane usher protein
YP_215284.1	IPR000847: Bacterial regulatory protein LysR, HTH motif; IPR005119: LysR substrate binding domain
YP_215291.1	IPR000485: Bacterial regulatory proteins, AsnC/Lrp
YP_215296.1	IPR003010: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase
YP_215297.1	functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA
YP_215298.1	catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate
YP_215301.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_215302.2	mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY
YP_215303.1	similar to release factor 1 and 2
YP_215304.1	IPR001160: Peptidase M20C, X-His dipeptidase
YP_215305.1	catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively
YP_215306.1	forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation
YP_215307.1	involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS
YP_215308.1	IPR001702: Porin, Gram-negative type; IPR001897: Porin, bacterial type
YP_215309.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_215310.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_215311.1	IPR002104: Phage integrase
YP_215312.1	IPR000504: RNA-binding region RNP-1  (RNA recognition motif)
YP_215319.1	IPR000424: Single-strand binding protein
YP_215320.1	similar to Orf-235 in Salmonella typhimurium bacteriophage ST64T
YP_215322.1	similar to C3 protein in Salmonella typhimurium bacteriophage ST64T; IPR000278: Lambdoid phages regulatory protein CIII
YP_215324.1	similar to 43L protein in Xanthomonas oryzae bacteriophage Xp10
YP_215329.1	similar to Nin protein in Bacteriophage lambda
YP_215331.1	DLP12 prophage; Holliday junction resolvase
YP_215333.1	similar to gp23 in Salmonella typhimurium bacteriophage ST64T
YP_215334.1	similar to holin protein in Bacteriophage HK620
YP_215341.1	similar to gp2 in Salmonella typhimurium bacteriophage ST64T
YP_215351.1	IPR001917: Aminotransferase, class-II
YP_215356.1	IPR001173: Glycosyl transferase, family 2
YP_215357.1	IPR007267: GtrA-like protein
YP_215360.1	IPR005829: Sugar transporter superfamily; IPR007114: Major facilitator superfamily
YP_215361.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_215364.1	IPR000379: Esterase/lipase/thioesterase; IPR000639: Epoxide hydrolase; IPR003089: Alpha/beta hydrolase
YP_215368.1	IPR000015: Fimbrial biogenesis outer membrane usher protein
YP_215369.1	IPR001829: Bacterial pili assembly chaperone
YP_215373.1	IPR000209: Peptidase S8, subtilase serine protease; IPR001633: EAL domain
YP_215376.1	IPR000758: Virulence-related outer membrane protein
YP_215377.1	IPR000792: Bacterial regulatory protein, LuxR family
YP_215381.1	IPR006143: Secretion protein HlyD
YP_215382.1	IPR000551: Bacterial regulatory protein, MerR family
YP_215383.1	IPR006191: Heavy metal binding
YP_215384.1	IPR005829: Sugar transporter superfamily; IPR007114: Major facilitator superfamily
YP_215385.1	IPR001091: Site-specific DNA-methyltransferase (cytosine-N4-specific); IPR001917: Aminotransferase, class-II; IPR002052: N-6 Adenine-specific DNA methylase;IPR002295: N6 adenine-specific DNA methyltransferase, D21 class
YP_215386.1	IPR006935: Type III restriction enzyme, res subunit
YP_215391.1	IPR000005: Helix-turn-helix, AraC type
YP_215392.1	IPR000531: TonB-dependent receptor protein
YP_215393.1	IPR001123: Lysine exporter protein (LYSE/YGGA)
YP_215395.1	IPR001254: Peptidase S1, chymotrypsin family; IPR002078: Sigma-54 factor interaction domain; IPR002197: Helix-turn-helix, Fis-type
YP_215396.1	catalyzes the formation of pyruvate and succinate from 2-methylisocitrate
YP_215397.1	catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity
YP_215398.1	functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C
YP_215399.1	catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent
YP_215400.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_215401.1	similar to 3rd module of ATP-binding components of transporters; IPR003991: Pertactin virulence factor, C-terminal
YP_215403.1	this protein has no known enzymatic function
YP_215404.1	in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope
YP_215408.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_215410.1	IPR001958: Tetracycline resistance protein; IPR007114: Major facilitator superfamily
YP_215413.1	catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis
YP_215414.1	catalyzes the formation of L-proline from pyrroline-5-carboxylate
YP_215415.1	IPR003791: Protein of unknown function DUF188
YP_215416.1	type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_215420.2	Required for efficient pilin antigenic variation
YP_215421.1	catalyzes phosphorylation of fructose; cytosolic enzyme
YP_215422.1	member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers
YP_215423.1	with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity
YP_215424.1	with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity
YP_215425.1	two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB
YP_215426.1	membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB
YP_215429.2	cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation
YP_215432.1	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
YP_215433.1	Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step
YP_215434.1	Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
YP_215435.1	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_215436.1	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_215437.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_215440.1	IPR000345: Cytochrome c  heme-binding site
YP_215441.1	IPR003055: Nucleoside-specific channel-forming protein, Tsx
YP_215444.1	riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil
YP_215445.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_215446.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_215447.1	catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP
YP_215448.1	hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate
YP_215449.1	IPR001395: Aldo/keto reductase
YP_215450.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_215451.1	IPR000092: Polyprenyl synthetase
YP_215452.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_215453.1	Required for the synthesis of the thiazole moiety
YP_215455.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_215456.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_215458.1	IPR000524: Bacterial regulatory protein, GntR family
YP_215459.1	catalyzes the formation of phosphonoacetaldehyde from 2-aminoethylphosphonate and pyruvate
YP_215460.1	catalyzes the degradation of phosphonoacetaldehyde to acetaldehyde and phosphate
YP_215462.1	ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis
YP_215463.1	nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_215464.1	IPR007114: Major facilitator superfamily
YP_215468.1	converts protoheme IX and farnesyl diphosphate to heme O
YP_215470.1	IPR000298: Cytochrome c oxidase, subunit III
YP_215471.1	IPR000883: Cytochrome c oxidase, subunit I
YP_215473.1	in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein
YP_215474.2	IPR005619: Uncharacterized lipoprotein
YP_215475.1	positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress
YP_215476.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_215477.2	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_215478.1	binds and unfolds substrates as part of the ClpXP protease
YP_215479.1	IPR001412: Aminoacyl-tRNA  synthetase, class I; IPR001984: Peptidase family S16; IPR008268: Peptidase S16, active site
YP_215480.1	histone-like DNA-binding protein
YP_215481.1	IPR000297: PpiC-type peptidyl-prolyl cis-trans isomerase
YP_215482.1	IPR000445: Helix-hairpin-helix motif
YP_215484.1	YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His
YP_215486.1	IPR000150: Cof protein
YP_215487.1	IPR001926: Pyridoxal-5'-phosphate-dependent enzyme, beta family
YP_215488.1	IPR000485: Bacterial regulatory proteins, AsnC/Lrp
YP_215489.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_215490.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_215492.1	indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.
YP_215493.1	IPR001905: Ammonium transporter; IPR002229: Blood group Rhesus C/E and D polypeptide
YP_215497.1	IPR001633: EAL domain
YP_215498.1	RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_215499.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif
YP_215501.1	IPR001451: Bacterial transferase hexapeptide repeat
YP_215502.1	with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins
YP_215504.1	IPR001036: Acriflavin resistance protein
YP_215506.2	small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS
YP_215509.1	PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks
YP_215511.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_215512.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_215514.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_215515.1	molecular chaperone
YP_215516.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_215518.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_215519.1	IPR000379: Esterase/lipase/thioesterase; IPR002168: Lipolytic enzyme
YP_215520.1	IPR002173: Carbohydrate kinase, PfkB
YP_215521.1	YbaL; member of the CPA-2 family of antiporters; uncharacterized protein
YP_215522.1	IPR007114: Major facilitator superfamily
YP_215523.1	catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides
YP_215526.1	IPR000150: Cof protein; IPR000695: H+ transporting ATPase, proton pump; IPR001756: Copper-transporting ATPase;IPR001757: ATPase, E1-E2 type;IPR006121: Heavy metal transport/detoxification protein;IPR006191: Heavy metal binding
YP_215527.1	activator of copper-responsive regulon genes
YP_215529.1	IPR001972: Stomatin
YP_215530.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_215532.1	IPR006663: Thioredoxin domain 2
YP_215533.1	IPR002198: Short-chain dehydrogenase/reductase SDR; IPR002347: Glucose/ribitol dehydrogenase; IPR003560: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
YP_215534.1	IPR001087: Lipolytic enzyme, G-D-S-L family; IPR008265: Lipolytic enzyme, G-D-S-L, active site
YP_215535.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter; IPR006073: GTP1/OBG
YP_215539.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_215540.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_215541.1	catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
YP_215542.1	activator of the allDC-ylbA operon involved in allantoin utilization
YP_215543.1	catalyzes the formation of glyoxylate from (S)-ureidoglycolate
YP_215544.1	regulates operons involved in the utilization of allantoin
YP_215545.1	IPR000560: Histidine acid phosphatase
YP_215546.1	IPR002204: 3-hydroxyisobutyrate dehydrogenase
YP_215547.1	IPR007114: Major facilitator superfamily
YP_215548.1	IPR001248: Permease for cytosine/purines, uracil, thiamine, allantoin
YP_215549.1	Plays a crucial role on both purine and pyrimidine metabolism
YP_215550.1	IPR000531: TonB-dependent receptor protein
YP_215553.1	allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide
YP_215554.1	IPR001064: Beta and gamma crystallin
YP_215555.1	multicopy suppressor of dominant negative ftsH mutations
YP_215558.1	forms a homodimer; may be used to synthesize carbomyl phosphate from ATP and carbamate
YP_215559.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_215560.1	Catalyzes a step in the de novo purine nucleotide biosynthetic pathway
YP_215561.1	catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine
YP_215562.1	IPR002130: Peptidyl-prolyl cis-trans isomerase, cyclophilin type
YP_215563.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_215567.2	IPR002942: RNA-binding S4
YP_215568.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_215572.1	IPR000015: Fimbrial biogenesis outer membrane usher protein
YP_215575.1	activates the production of the major fimbrae protein FimA
YP_215576.1	IPR000792: Bacterial regulatory protein, LuxR family
YP_215577.1	IPR000792: Bacterial regulatory protein, LuxR family
YP_215580.1	IPR001173: Glycosyl transferase, family 2
YP_215583.1	IPR001173: Glycosyl transferase, family 2
YP_215585.1	IPR000504: RNA-binding region RNP-1  (RNA recognition motif)
YP_215586.1	IPR004358: Bacterial sensor protein, C-terminal; IPR005467: Histidine kinase
YP_215587.1	IPR000005: Helix-turn-helix, AraC type
YP_215588.1	Involved in disulfide oxidoreductase activity and electron transport
YP_215592.1	IPR002293: Amino acid/polyamine transporter family I; IPR004840: Amino acid permease
YP_215595.1	IPR001087: Lipolytic enzyme, G-D-S-L family
YP_215596.1	catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive
YP_215598.1	IPR001647: Bacterial regulatory protein TetR, HTH motif
YP_215599.1	IPR000005: Helix-turn-helix, AraC type
YP_215601.1	ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity
YP_215602.1	IPR003542: Enterobactin synthetase, component D
YP_215603.1	Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space
YP_215604.1	IPR000379: Esterase/lipase/thioesterase
YP_215606.1	with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin
YP_215607.1	part of the ferric enterobactin transport system; necessary for enetrobactin uptake
YP_215608.1	with FepBDE is involved in the transport of ferric enterobactin
YP_215609.1	with FepBCD is involved in the transport of ferric enterobactin
YP_215610.1	with FepBCG is involved in the transport of ferric enterobactin
YP_215611.1	protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters
YP_215612.1	with FepCDG is involved in the transport of ferric enterobactin
YP_215613.2	synthesizes isochorismate acid from chorismate
YP_215614.1	bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate
YP_215615.1	IPR003881: Isochorismatase; IPR006163: Phosphopantetheine-binding domain
YP_215616.1	catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin
YP_215620.1	member of the iron-containing alcohol dehydrogenase family; unknown function
YP_215621.1	catalyzes the transfer of an amino moiety
YP_215624.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_215625.1	Involved in disulfide bond formation
YP_215626.1	with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate
YP_215627.1	IPR000103: Pyridine nucleotide-disulphide oxidoreductase, class-II; IPR000759: Adrenodoxin reductase; IPR001100: Pyridine nucleotide-disulphide oxidoreductase, class I;IPR001327: FAD-dependent pyridine nucleotide-disulphide oxidoreductase;IPR003042: Aromatic-ring hydroxylase;IPR008255: Pyridine nucleotide-disulphide oxidoreductase, class-II, active site
YP_215630.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_215632.1	IPR006015: Universal stress protein (Usp)
YP_215633.1	Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation
YP_215635.1	catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA
YP_215636.1	2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate
YP_215637.1	bifunctional
YP_215639.1	acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate
YP_215640.1	IPR000182: GCN5-related N-acetyltransferase; IPR004821: Cytidyltransferase-related domain; IPR005216: Citrate lyase ligase
YP_215642.1	IPR004358: Bacterial sensor protein, C-terminal; IPR005467: Histidine kinase
YP_215643.1	regulates the expression of citAB in citrate fermentation
YP_215644.1	responsible for the transport of C4-dicarboxylates during anaerobic growth
YP_215645.2	member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator
YP_215646.1	may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling
YP_215647.1	IPR001110: Protein of unknown function UPF0012; IPR003010: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase
YP_215648.1	TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_215649.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_215650.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_215651.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_215653.1	penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
YP_215656.1	IPR001182: Cell cycle protein
YP_215658.1	SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA
YP_215660.1	IPR001345: Phosphoglycerate/bisphosphoglycerate mutase
YP_215661.1	cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase
YP_215662.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_215663.1	required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA
YP_215664.1	rare lipoprotein B; involved in the assembly of LPS in the outer membrane
YP_215665.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_215667.1	transports degraded pectin products into the bacterial cell
YP_215668.1	IPR002078: Sigma-54 factor interaction domain; IPR002197: Helix-turn-helix, Fis-type
YP_215672.1	IPR001623: Heat shock protein DnaJ, N-terminal
YP_215674.1	IPR001023: Heat shock protein Hsp70
YP_215676.1	Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific
YP_215677.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_215680.1	IPR001311: Solute-binding protein/glutamate receptor; IPR001638: Bacterial extracellular solute-binding protein, family 3
YP_215681.1	Transfers the fatty acyl group on membrane lipoproteins
YP_215682.1	IPR000644: CBS domain
YP_215683.1	IPR002036: Protein of unknown function UPF0054
YP_215684.1	IPR003714: PhoH-like protein
YP_215685.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_215686.1	catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q
YP_215688.1	functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP
YP_215690.1	IPR000600: ROK family
YP_215691.1	catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate
YP_215692.1	catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate
YP_215693.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_215694.1	catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_215697.1	IPR005829: Sugar transporter superfamily; IPR007114: Major facilitator superfamily
YP_215698.1	catalyzes the oxidation of tricarballylate to cis-aconitate; FAD-dependent; required for the utilization of tricarballylate as a carbon and energy source by S. enterica
YP_215700.1	negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer
YP_215701.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_215703.1	IPR000379: Esterase/lipase/thioesterase; IPR003089: Alpha/beta hydrolase
YP_215704.2	negative modulator of the initiation of chromosome replication
YP_215705.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_215707.1	catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system
YP_215708.1	IPR000310: Orn/Lys/Arg decarboxylase, major region
YP_215709.1	response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport
YP_215710.1	sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein
YP_215711.1	One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex
YP_215712.1	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_215713.1	catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_215714.1	one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_215715.1	UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent
YP_215716.1	IPR000109: TGF-beta receptor, type I/II extracellular region; IPR007114: Major facilitator superfamily
YP_215721.1	5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity
YP_215722.1	IPR002155: Thiolase
YP_215723.1	type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH
YP_215724.1	IPR000701: Succinate dehydrogenase, cytochrome b subunit
YP_215725.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_215726.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase
YP_215727.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_215728.1	component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA
YP_215729.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_215730.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_215735.1	catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components
YP_215736.1	membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_215737.1	membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_215738.1	inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins
YP_215739.1	forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA
YP_215740.1	IPR006664: Bacterial outer membrane protein; IPR006665: OmpA/MotB domain; IPR006690: OmpA-like domain
YP_215741.1	periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity
YP_215742.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_215744.1	involved in zinc efflux across the cytoplasmic membrane
YP_215746.2	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_215748.1	Catalyzes the reversible hydration of fumaric acid to yield I-malic acid
YP_215749.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_215751.1	catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide
YP_215752.1	catalyzes the formation of pyruvate from oxaloacetate
YP_215755.1	IPR000522: FecCD transport family; IPR001851: Bacterial inner-membrane translocator
YP_215756.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_215757.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_215758.1	catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose
YP_215759.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_215760.1	catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P
YP_215763.2	contains 2 ATP-binding cassettes; involved in the transport of molybdenum
YP_215764.1	represses the modABCD operon and activates the moaABCD and napFDAGHBC operons
YP_215766.1	with ModCB is involved in the high-affinity transport of molybdate
YP_215767.1	part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE
YP_215768.1	Part of the ABC transporter complex modABC involved in molybdenum import
YP_215769.1	YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily
YP_215770.1	catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
YP_215771.1	outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family
YP_215772.2	catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway
YP_215773.1	catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate
YP_215774.1	IPR000524: Bacterial regulatory protein, GntR family
YP_215775.1	catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism
YP_215776.1	catalyzes the degradation of histidine to urocanate and ammmonia
YP_215777.1	YbhB; similar to rat and human kinase inhibitory proteins
YP_215778.2	catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate
YP_215780.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_215781.1	methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth
YP_215782.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_215783.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_215787.1	together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z
YP_215788.1	IPR001453: Molybdenum cofactor biosynthesis protein; IPR008284: Molybdenum cofactor biosynthesis protein, N-terminal
YP_215789.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_215790.1	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_215791.1	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_215796.1	IPR001736: Phospholipase D/Transphosphatidylase
YP_215799.1	IPR000412: ABC transporter family 2
YP_215801.1	IPR001553: RecA bacterial DNA recombination protein; IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_215803.1	IPR001647: Bacterial regulatory protein TetR, HTH motif
YP_215804.1	this helicase is not essential cell growth
YP_215805.1	helicase involved in DNA repair and perhaps also replication
YP_215808.1	IPR000962: Zn-finger, prokaryotic DksA/TraR C4 type
YP_215810.1	similar to ATP-binding component of ABC transporters
YP_215811.1	similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine
YP_215812.1	similar to periplasmic-binding component of ABC transporters
YP_215813.1	binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage
YP_215816.1	OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains
YP_215819.1	Transcriptional regulator that represses the manganese transporter MntH when manganese is present
YP_215822.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_215824.1	IPR000150: Cof protein
YP_215825.1	IPR001150: Formate C-acetyltransferase glycine radical
YP_215826.1	IPR001989: Radical-activating enzyme
YP_215827.1	ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase
YP_215828.1	is involved in the formation of active molybdenum cofactor and the chelation of molybdenum
YP_215830.1	with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains
YP_215831.1	IPR000914: Bacterial extracellular solute-binding protein, family 5
YP_215832.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_215833.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_215834.1	catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit
YP_215835.1	IPR000049: Electron transfer flavoprotein beta-subunit
YP_215836.1	IPR001308: Electron transfer flavoprotein, alpha subunit
YP_215838.1	IPR006089: Acyl-CoA dehydrogenase
YP_215839.1	IPR000205: NAD-binding site; IPR003042: Aromatic-ring hydroxylase
YP_215842.1	IPR003220: Insertion element protein
YP_215843.1	IPR004045: Glutathione S-transferase, N-terminal; IPR004046: Glutathione S-transferase, C-terminal
YP_215844.1	penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains
YP_215845.1	IPR001034: Bacterial regulatory protein, DeoR family
YP_215846.1	IPR000326: PA-phosphatase related phosphoesterase
YP_215847.1	IPR005829: Sugar transporter superfamily; IPR007114: Major facilitator superfamily
YP_215848.1	IPR000150: Cof protein
YP_215849.1	IPR007114: Major facilitator superfamily
YP_215850.1	IPR001647: Bacterial regulatory protein TetR, HTH motif
YP_215853.1	functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase
YP_215854.1	YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function
YP_215855.1	responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6
YP_215857.1	IPR001188: Bacterial periplasmic spermidine/putrescine-binding protein
YP_215858.1	part of the PotFGHI ATP-dependent putrescine transporter
YP_215859.1	IPR000515: Binding-protein-dependent transport systems inner membrane component; IPR000834: Zinc carboxypeptidase A metalloprotease (M14)
YP_215860.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_215862.1	RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA
YP_215863.1	membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr
YP_215864.1	similar to SgaT from Vibrio
YP_215866.1	IPR001311: Solute-binding protein/glutamate receptor; IPR001638: Bacterial extracellular solute-binding protein, family 3
YP_215867.1	with ArtPQJI acts to transport arginine across the inner membrane
YP_215868.1	with ArtPMJI transports arginine across the inner membrane
YP_215869.1	IPR001311: Solute-binding protein/glutamate receptor; IPR001638: Bacterial extracellular solute-binding protein, family 3
YP_215870.1	With ArtMQJI transports arginine across the inner membrane
YP_215871.1	induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS
YP_215872.1	orfB
YP_215876.1	low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine
YP_215877.1	catalyzes the formation of acetate from pyruvate
YP_215878.1	IPR000951: Phthalate dioxygenase reductase; IPR001041: Ferredoxin; IPR001221: Phenol hydroxylase reductase;IPR001433: Oxidoreductase FAD/NAD(P)-binding;IPR008333: Oxidoreductase FAD-binding region
YP_215879.1	catalyzes the reduction of hydroxylamine to ammonia and water
YP_215880.1	IPR005642: Membrane protein of unknown function DUF340
YP_215883.1	confers macrolide resistance via active drug efflux
YP_215884.1	with MacA is involved in the export of macrolide
YP_215885.1	but not cold shock induced; IPR002059: Cold-shock DNA-binding domain
YP_215886.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_215887.1	ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates
YP_215894.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_215896.1	leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys
YP_215897.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_215898.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_215899.1	catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding
YP_215900.1	mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system
YP_215901.1	DNA-binding membrane protein required for chromosome resolution and partitioning
YP_215902.1	participates with LolB in the incorporation of lipoprotein into the outer membrane
YP_215903.1	IPR000862: Replication factor C conserved domain
YP_215904.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_215905.1	IPR006311: Twin-arginine translocation pathway signal; IPR006655: Prokaryotic molybdopterin oxidoreductase; IPR006656: Molybdopterin oxidoreductase;IPR006657: Molydopterin dinucleotide binding domain;IPR006963: Molybdopterin oxidoreductase Fe4S4 domain
YP_215906.1	IPR000345: Cytochrome c  heme-binding site; IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_215909.1	IPR000276: Rhodopsin-like GPCR superfamily; IPR001064: Beta and gamma crystallin; IPR007114: Major facilitator superfamily
YP_215910.1	IPR002293: Amino acid/polyamine transporter family I
YP_215911.2	activates pyruvate formate-lyase 1 under anaerobic conditions
YP_215914.1	IPR001150: Formate C-acetyltransferase glycine radical
YP_215915.1	IPR000292: Formate/nitrite transporter
YP_215918.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine
YP_215919.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_215920.1	IPR006025: Neutral zinc metallopeptidases, zinc-binding site
YP_215921.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_215922.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_215923.1	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_215928.1	involved in the transport of lipid A across the inner membrane
YP_215929.1	transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate
YP_215932.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_215936.1	involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA
YP_215937.1	acts with MukB and MukE to condense the chromosome and allow for segregation during cell division
YP_215938.1	acts with MukB and MukF to condense the chromosome and allow for segregation during cell division
YP_215939.1	IPR001064: Beta and gamma crystallin; IPR002052: N-6 Adenine-specific DNA methylase
YP_215942.1	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_215943.1	IPR001702: Porin, Gram-negative type; IPR001897: Porin, bacterial type
YP_215944.1	catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_215945.1	IPR000485: Bacterial regulatory proteins, AsnC/Lrp
YP_215946.1	catalyzes the formation of pyruvate from 2,3-diaminopropionate
YP_215948.1	IPR001463: Sodium:alanine symporter; IPR002293: Amino acid/polyamine transporter family I
YP_215949.1	catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate
YP_215952.1	IPR004590: RecT protein
YP_215961.1	similar to cI protein in phage N
YP_215970.1	similar to antiterminator Q
YP_215971.1	IPR006025: Neutral zinc metallopeptidases, zinc-binding site
YP_215983.1	IPR000758: Virulence-related outer membrane protein
YP_215984.1	IPR001424: Copper/Zinc superoxide dismutase
YP_215989.1	IPR000104: Antifreeze protein, type I
YP_215997.2	IPR001930: Peptidase M1, membrane alanine aminopeptidase; IPR006025: Neutral zinc metallopeptidases, zinc-binding site
YP_215998.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_216001.1	catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA
YP_216006.1	catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP
YP_216007.1	IPR001984: Peptidase family S16
YP_216009.1	OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d
YP_216012.1	IPR005829: Sugar transporter superfamily
YP_216014.1	catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand
YP_216015.1	catalyzes the formation of methylglyoxal from glycerone phosphate
YP_216017.1	IPR003781: CoA-binding domain
YP_216019.1	IPR000051: SAM (and some other nucleotide) binding motif; IPR002478: PUA domain
YP_216021.1	IPR000005: Helix-turn-helix, AraC type
YP_216022.1	catalyzes the hydrolysis of acylphosphate
YP_216023.1	transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs
YP_216024.1	IPR006213: Bax inhibitor 1
YP_216026.1	IPR006025: Neutral zinc metallopeptidases, zinc-binding site
YP_216027.1	IPR000169: Eukaryotic thiol (cysteine) protease
YP_216030.1	similar to ipgD of Shigella
YP_216032.1	IPR003660: Histidine kinase, HAMP region; IPR005467: Histidine kinase
YP_216033.2	induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced
YP_216034.1	IPR000895: Transthyretin
YP_216037.1	IPR000835: Bacterial regulatory protein, MarR family
YP_216039.1	IPR002086: Aldehyde dehydrogenase
YP_216042.1	IPR002607: Hydratase/decarboxylase
YP_216044.1	IPR007114: Major facilitator superfamily
YP_216045.1	IPR000005: Helix-turn-helix, AraC type
YP_216049.1	with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA
YP_216050.1	functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock
YP_216051.1	IPR002016: Haem peroxidase
YP_216052.1	IPR006662: Thioredoxin type domain; IPR006663: Thioredoxin domain 2
YP_216053.1	IPR006663: Thioredoxin domain 2
YP_216054.1	IPR000560: Histidine acid phosphatase
YP_216056.1	IPR008254: Flavodoxin/nitric oxide synthase
YP_216059.1	IPR001647: Bacterial regulatory protein TetR, HTH motif
YP_216061.1	proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein
YP_216063.1	IPR001734: Na+/solute symporter
YP_216064.1	IPR003714: PhoH-like protein
YP_216066.1	Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate
YP_216067.1	IPR006652: Kelch repeat
YP_216069.1	IPR000683: Oxidoreductase, N-terminal; IPR000847: Bacterial regulatory protein LysR, HTH motif; IPR004104: Oxidoreductase, C-terminal
YP_216075.1	nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex
YP_216076.1	chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex
YP_216077.1	activates the csgBA and csgDEFG operons involved in biofilm formation
YP_216078.1	CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface
YP_216080.2	involved in autoagglutination of curliated cells; not involved in production of curli fibers
YP_216082.1	IPR001736: Phospholipase D/Transphosphatidylase
YP_216083.1	required for the transfer of succinyl residues to the glucan backbone
YP_216084.1	involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan
YP_216085.1	necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space
YP_216088.1	Confers resistance to fosfomycin and deoxycholate
YP_216089.2	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_216090.1	IPR001763: Rhodanese-like
YP_216092.1	IPR000516: Nickel-dependent hydrogenase b-type cytochrome subunit
YP_216095.1	catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids
YP_216096.1	BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing
YP_216098.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_216100.1	cofactor involved in the reduction of disulfides
YP_216101.1	Confers resistance to norfloxacin and enoxacin
YP_216105.1	for FlgK and FlgL
YP_216106.1	regulates the flagellar specific sigma28 transcription factor
YP_216107.1	required for the assembly of the flagellar basal body P-ring
YP_216108.1	with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella
YP_216109.1	with FlgF and B makes up the proximal portion of the flagellar basal body rod
YP_216110.1	acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production
YP_216111.1	the hook connects flagellar basal body to the flagellar filament
YP_216112.1	FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod
YP_216113.1	makes up the distal portion of the flagellar basal body rod
YP_216114.1	part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod
YP_216115.1	part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum
YP_216116.1	Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space
YP_216117.1	with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook
YP_216118.1	with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes
YP_216119.1	bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase
YP_216121.2	catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA
YP_216124.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_216126.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_216127.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY
YP_216128.1	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_216130.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_216131.1	carries the fatty acid chain in fatty acid biosynthesis
YP_216132.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_216135.1	catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate
YP_216136.1	IPR003770: Protein of unknown function DUF175
YP_216137.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_216138.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_216139.1	IPR001130: TatD-related deoxyribonuclease
YP_216140.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_216141.1	IPR000531: TonB-dependent receptor protein
YP_216142.1	IPR001310: Histidine triad (HIT) protein
YP_216145.1	catalyzes the phosphorylation of thiamine to thiamine phosphate
YP_216146.1	hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
YP_216150.1	IPR001647: Bacterial regulatory protein TetR, HTH motif
YP_216153.1	IPR001410: DEAD/DEAH box helicase
YP_216154.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_216155.1	outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone
YP_216156.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_216157.1	catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine
YP_216158.1	Modulates the activities of several enzymes which are inactive in their acetylated form
YP_216159.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate
YP_216160.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component
YP_216161.1	translocated by the type III secretion system SPI-2; required for the formation of lysosomal glycoprotein structures (Sifs); required for maintenance of membrane in the Salmonella-containing vacuole; a cysteine residue with CAAX motif is modified by isoprenoid addition of protein geranylgeranyl transferase I; also modified by S-acylation
YP_216163.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component
YP_216164.1	functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase
YP_216165.1	catalyzes the release of the N-terminal amino acid from a tripeptide
YP_216167.1	IPR007113: Cupin domain
YP_216168.1	IPR003660: Histidine kinase, HAMP region; IPR004358: Bacterial sensor protein, C-terminal; IPR005467: Histidine kinase
YP_216169.1	response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress
YP_216170.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_216171.1	HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis
YP_216172.2	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_216173.1	IPR000086: NUDIX hydrolase
YP_216175.1	IPR000748: Pseudouridine synthase, Rsu
YP_216176.1	Converts isocitrate to alpha ketoglutarate
YP_216189.1	IPR002052: N-6 Adenine-specific DNA methylase
YP_216190.1	IPR008822: Endodeoxyribonuclease RusA
YP_216195.1	IPR001091: Site-specific DNA-methyltransferase (cytosine-N4-specific)
YP_216201.1	similar to DNA packaging protein Nu1 of phage 21
YP_216202.1	similar to terminase large chain gp2 of N15
YP_216203.1	similar to head to tail joining protein; IPR004174: Head-to-tail joining protein W, gpW
YP_216204.1	similar to head-tail preconnector gp4 of phage 21
YP_216205.1	similar to head-tail preconnector gp5 of phage 21; IPR002142: Peptidase U7
YP_216206.1	similar to head protein gpshp of phage 21; IPR004195: Bacteriophage lambda head decoration protein D, HDPD
YP_216207.1	similar to head protein gp7 of phage 21
YP_216208.1	similar to DNA packaging protein gp9 of phage N14
YP_216209.1	similar to minor capsid protein FII of phage N15
YP_216211.1	similar to minor tail protein Z
YP_216213.1	similar to major tail protein
YP_216215.1	similar to minor tail protein
YP_216216.1	similar to phage tail component H
YP_216217.1	similar to phage tail component M
YP_216218.1	similar to phage tail component L
YP_216219.1	similar to tail assembly protein K in phage lambda
YP_216220.1	similar to tail assembly protein I in phage lambda
YP_216221.1	similar to host specificity protein-J in phage lambda
YP_216223.1	IPR000104: Antifreeze protein, type I
YP_216230.1	IPR000914: Bacterial extracellular solute-binding protein, family 5
YP_216240.1	IPR000772: Ricin B lectin domain
YP_216243.1	IPR000758: Virulence-related outer membrane protein
YP_216244.1	PliC; periplasmic lysozyme inhibitor of c-type lysozyme
YP_216249.1	IPR002068: Heat shock protein Hsp20
YP_216255.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_216257.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_216258.1	IPR003439: ABC transporter
YP_216262.1	streptomycin 3'-adenyltransferase
YP_216263.1	IPR000792: Bacterial regulatory protein, LuxR family
YP_216264.1	IPR000551: Bacterial regulatory protein, MerR family
YP_216266.1	catalyzes the interconversion of chorismate to prephenate
YP_216267.1	IPR001123: Lysine exporter protein (LYSE/YGGA)
YP_216276.1	IPR007114: Major facilitator superfamily
YP_216277.1	IPR000005: Helix-turn-helix, AraC type
YP_216282.1	IPR000160: GGDEF
YP_216283.1	IPR006698: Protein of unknown function DUF444
YP_216286.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_216287.1	IPR001395: Aldo/keto reductase
YP_216290.1	catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate
YP_216291.1	this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress
YP_216293.1	IPR001579: Glycoside hydrolase, chitinase active site
YP_216294.1	IPR002328: Zinc-containing alcohol dehydrogenase
YP_216295.1	IPR007114: Major facilitator superfamily
YP_216296.1	IPR000205: NAD-binding site; IPR002328: Zinc-containing alcohol dehydrogenase
YP_216297.1	IPR000771: Ketose-bisphosphate aldolase, class-II
YP_216298.1	IPR002139: Ribokinase; IPR002173: Carbohydrate kinase, PfkB
YP_216299.1	IPR001395: Aldo/keto reductase
YP_216300.1	IPR001034: Bacterial regulatory protein, DeoR family
YP_216301.1	IPR005828: General substrate transporter; IPR007114: Major facilitator superfamily
YP_216302.1	catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide
YP_216303.1	converts asparagine to aspartate and ammonia
YP_216304.1	SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane
YP_216306.1	catalyzes the formation of selenophosphate from selenide and ATP
YP_216307.1	decatenates replicating daughter chromosomes
YP_216308.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_216310.1	IPR000086: NUDIX hydrolase
YP_216311.1	removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction
YP_216313.1	catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate
YP_216315.1	catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism
YP_216316.1	periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP
YP_216317.1	3' incision activity; acts with UvrC
YP_216318.1	catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers
YP_216319.1	osmotically-inducible lipoprotein E; activator of ntr-like gene protein
YP_216320.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_216321.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_216322.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_216323.1	represses the celABCDF-ydjC operon involved in carbon uptake
YP_216324.1	IPR001088: Glycoside hydrolase, family 4
YP_216326.1	Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide
YP_216328.1	IPR001991: Sodium:dicarboxylate symporter
YP_216329.2	IPR007404: Predicted membrane-bound metal-dependent hydrolase
YP_216330.1	YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate
YP_216334.1	IPR002173: Carbohydrate kinase, PfkB
YP_216338.1	IPR001604: DNA/RNA non-specific endonuclease
YP_216339.1	catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_216340.1	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits
YP_216341.2	IPR001706: Ribosomal protein L35
YP_216342.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_216343.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_216344.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_216345.1	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_216346.1	with BtuD and BtuF transports vitamin B12 into the cell
YP_216347.1	similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane
YP_216348.1	ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell
YP_216353.1	tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate
YP_216355.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_216356.1	acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids
YP_216357.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_216358.1	IPR000205: NAD-binding site; IPR001100: Pyridine nucleotide-disulphide oxidoreductase, class I; IPR001327: FAD-dependent pyridine nucleotide-disulphide oxidoreductase;IPR003042: Aromatic-ring hydroxylase
YP_216359.1	May play a role in a redox process
YP_216360.1	YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain
YP_216361.1	IPR000005: Helix-turn-helix, AraC type; IPR007113: Cupin domain
YP_216362.1	may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain
YP_216364.1	catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis
YP_216365.1	YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate
YP_216366.1	IPR007114: Major facilitator superfamily
YP_216367.1	IPR000524: Bacterial regulatory protein, GntR family; IPR005828: General substrate transporter; IPR005829: Sugar transporter superfamily;IPR007114: Major facilitator superfamily
YP_216371.1	YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function
YP_216372.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_216373.1	IPR003736: Phenylacetic acid degradation-related protein; IPR006683: Thioesterase superfamily
YP_216375.1	IPR001991: Sodium:dicarboxylate symporter
YP_216376.1	functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein
YP_216377.1	with SufCD activates cysteine desulfurase SufS
YP_216378.1	part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE
YP_216379.1	with SufBC activates cysteine desulfurase SufS
YP_216380.1	catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine
YP_216381.1	Acts with SufS to catalyze the formation of L-alanine from L-cysteine
YP_216385.1	links outer and inner membranes
YP_216386.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_216387.1	IPR002293: Amino acid/polyamine transporter family I
YP_216388.1	IPR000379: Esterase/lipase/thioesterase; IPR002410: Prolyl aminopeptidase S33
YP_216389.1	orf245; IPR003006: Immunoglobulin/major histocompatibility complex
YP_216390.1	IPR001034: Bacterial regulatory protein, DeoR family; IPR002139: Ribokinase; IPR002173: Carbohydrate kinase, PfkB
YP_216393.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_216394.1	IPR003594: ATP-binding region, ATPase-like; IPR003661: Histidine kinase A, N-terminal; IPR004358: Bacterial sensor protein, C-terminal;IPR005467: Histidine kinase
YP_216395.1	IPR000792: Bacterial regulatory protein, LuxR family; IPR001789: Response regulator receiver
YP_216396.1	orf70
YP_216397.1	orf319
YP_216398.1	orf242; IPR000551: Bacterial regulatory protein, MerR family
YP_216399.1	IPR000792: Bacterial regulatory protein, LuxR family; IPR001789: Response regulator receiver
YP_216400.1	IPR001789: Response regulator receiver; IPR003660: Histidine kinase, HAMP region; IPR004358: Bacterial sensor protein, C-terminal;IPR005467: Histidine kinase
YP_216402.1	IPR001775: Bacterial general secretion pathway protein D; IPR003522: Type III secretion system outer membrane G protein; IPR004845: Bacterial type II secretion system protein D
YP_216407.1	IPR005415: Gram-negative bacterial type III secretion SycD chaperone
YP_216411.1	IPR001440: TPR repeat
YP_216417.1	similar to  the yscJ/mxiJ/prgK family of lipoproteins; IPR003282: Type III secretion system outer membrane K protein; IPR006182: Secretory protein YscJ/FliF
YP_216422.1	with SsaC forms part of a protein export system across the inner and outer cell membranes; part of the Salmonella pathogenicity island 2; part of the type III secretion system
YP_216423.1	similar to the YscN family of proteins
YP_216426.1	IPR001172: Flagellar motor switch FliN protein
YP_216427.1	part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response
YP_216428.1	similar to YscS of the secretion system of Yersinia
YP_216429.1	similar to YscT of the secretion system of Yersinia; IPR002010: Bacterial export protein, family 1
YP_216430.1	member of a type III secretion system which is part of a pathogenicity island in Salmonella, Yersinia and pathogenic Escherichia coli
YP_216431.1	NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones
YP_216432.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_216433.1	catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge
YP_216434.1	uncharacterized member of the major facilitator superfamily (MFS)
YP_216435.1	IPR000847: Bacterial regulatory protein LysR, HTH motif; IPR005119: LysR substrate binding domain
YP_216436.1	binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers
YP_216437.1	SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals
YP_216438.1	IPR000064: NLP/P60
YP_216440.1	Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A)
YP_216441.1	Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione
YP_216442.1	FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide
YP_216445.1	IPR001395: Aldo/keto reductase
YP_216446.1	SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water
YP_216447.1	IPR002016: Haem peroxidase
YP_216449.1	Transcription regulator that can both activate or repress expression
YP_216451.1	catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling
YP_216452.1	MliC; membrane-bound lysozyme inhibitor of c-type lysozyme
YP_216453.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate
YP_216454.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_216455.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_216456.1	IPR004045: Glutathione S-transferase, N-terminal; IPR004046: Glutathione S-transferase, C-terminal
YP_216457.1	mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation
YP_216458.1	DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines
YP_216459.1	in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase
YP_216460.1	part of membrane-bound complex hought to be involved in electron transport to nitrogen
YP_216461.1	RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents
YP_216462.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_216463.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_216466.1	YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes
YP_216467.1	catalyzes the formation of inosine from adenosine
YP_216471.1	IPR001250: Mannose-6-phosphate isomerase, type I
YP_216472.1	IPR000362: Fumarate lyase
YP_216473.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_216474.1	binds to DNA replication terminator sequences to prevent passage of replication forks
YP_216475.1	IPR003660: Histidine kinase, HAMP region; IPR004358: Bacterial sensor protein, C-terminal; IPR005467: Histidine kinase
YP_216476.1	IPR005847: Dihydroorotase region
YP_216477.1	IPR000408: Regulator of chromosome condensation, RCC1; IPR001702: Porin, Gram-negative type; IPR001897: Porin, bacterial type
YP_216480.1	response regulator in two-component regulatory system with RstB
YP_216482.1	IPR002293: Amino acid/polyamine transporter family I
YP_216484.1	forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm
YP_216485.1	catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme
YP_216487.1	with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS
YP_216488.1	with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS
YP_216489.1	IPR001254: Peptidase S1, chymotrypsin family; IPR008256: Peptidase S1B, serine protease V8
YP_216490.2	required for growth and survival under moderately acid conditions
YP_216491.1	IPR005829: Sugar transporter superfamily; IPR007114: Major facilitator superfamily
YP_216492.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_216493.1	IPR000600: ROK family
YP_216494.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_216495.1	IPR000644: CBS domain; IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_216496.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_216498.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_216499.1	binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane
YP_216501.1	IPR000345: Cytochrome c  heme-binding site; IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_216502.1	IPR006655: Prokaryotic molybdopterin oxidoreductase
YP_216503.1	IPR006311: Twin-arginine translocation pathway signal; IPR006655: Prokaryotic molybdopterin oxidoreductase; IPR006656: Molybdopterin oxidoreductase;IPR006657: Molydopterin dinucleotide binding domain;IPR006963: Molybdopterin oxidoreductase Fe4S4 domain
YP_216508.2	IPR003844: Protein of unknown function UPF0060
YP_216509.1	starvation sensing protein; IPR001354: Mandelate racemase/muconate lactonizing enzyme
YP_216510.1	IPR002328: Zinc-containing alcohol dehydrogenase
YP_216511.1	IPR007114: Major facilitator superfamily
YP_216512.1	IPR000669: Mannitol dehydrogenase
YP_216514.1	IPR000524: Bacterial regulatory protein, GntR family
YP_216515.1	NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine
YP_216516.1	IPR006025: Neutral zinc metallopeptidases, zinc-binding site
YP_216521.1	YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters
YP_216522.1	IPR000620: Protein of unknown function DUF6
YP_216524.1	transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF
YP_216525.1	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
YP_216526.1	protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function
YP_216527.1	IPR007114: Major facilitator superfamily
YP_216528.1	in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase
YP_216529.1	catalyzes the formation of glutamate from glutamine
YP_216534.1	IPR001702: Porin, Gram-negative type; IPR001897: Porin, bacterial type
YP_216535.1	IPR000688: Hydrogenase expression/synthesis, HypA family
YP_216537.1	IPR001052: Rubredoxin; IPR004039: Rubredoxin-type Fe(Cys)4 protein
YP_216539.1	IPR001109: Hydrogenase expression/formation protein (HUPF/HYPC)
YP_216540.1	IPR000671: Hydrogen uptake protein
YP_216541.1	IPR000516: Nickel-dependent hydrogenase b-type cytochrome subunit
YP_216542.1	IPR001501: Nickel-dependent hydrogenase, large subunit
YP_216545.1	IPR007114: Major facilitator superfamily
YP_216553.1	protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase
YP_216554.2	malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate
YP_216555.1	similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs
YP_216556.1	nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase
YP_216557.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_216559.1	IPR001702: Porin, Gram-negative type; IPR001897: Porin, bacterial type
YP_216561.1	IPR001411: Tetracycline resistance protein TetB; IPR007114: Major facilitator superfamily
YP_216562.1	IPR001647: Bacterial regulatory protein TetR, HTH motif
YP_216564.1	IPR000345: Cytochrome c  heme-binding site
YP_216567.1	IPR001447: N-acetyltransferase
YP_216569.1	IPR002293: Amino acid/polyamine transporter family I; IPR004840: Amino acid permease; IPR004841: Amino acid permease-associated region
YP_216573.1	IPR002085: Zinc-containing alcohol dehydrogenase superfamily
YP_216581.2	catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation
YP_216582.1	IPR000524: Bacterial regulatory protein, GntR family; IPR004839: Aminotransferase, class I and II
YP_216583.1	IPR000755: D-ala-D-ala dipeptidase
YP_216585.1	similar to chitinase from Schizosaccharomyces
YP_216586.2	translocated by the type III secretion system SPI-2; localizes to Sifs in infected cells and specifically to Salmonella-containing vacuoles
YP_216588.1	IPR001539: Peptidase U32
YP_216590.1	IPR000005: Helix-turn-helix, AraC type; IPR004711: Benzoate membrane transport protein
YP_216592.1	with TehA confers resistance to tellurite
YP_216593.1	IPR004695: C4-dicarboxylate transporter/malic acid transport protein
YP_216598.1	IPR005137: BtpA family
YP_216599.1	IPR002178: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
YP_216600.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_216601.1	IPR001034: Bacterial regulatory protein, DeoR family
YP_216603.1	IPR003009: FMN/related compound-binding core; IPR008259: FMN-dependent alpha-hydroxy acid dehydrogenase, active site
YP_216604.1	IPR007372: YceI
YP_216605.1	involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans
YP_216606.1	IPR000276: Rhodopsin-like GPCR superfamily
YP_216607.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_216608.1	IPR003660: Histidine kinase, HAMP region; IPR004089: Bacterial chemotaxis sensory transducer; IPR004090: Methyl-accepting chemotaxis protein;IPR004091: Aspartate chemoreceptor protein
YP_216609.1	IPR002328: Zinc-containing alcohol dehydrogenase
YP_216613.1	IPR001087: Lipolytic enzyme, G-D-S-L family
YP_216617.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_216618.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_216621.1	IPR000051: SAM (and some other nucleotide) binding motif; IPR001601: Generic methyltransferase
YP_216623.2	involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
YP_216624.1	FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds
YP_216629.1	Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthes
YP_216630.1	IPR005184: Protein of unknown function DUF306
YP_216632.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_216633.1	IPR006015: Universal stress protein (Usp)
YP_216634.1	IPR000390: Small multidrug resistance protein
YP_216636.1	TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs
YP_216637.1	exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA
YP_216639.1	IPR003660: Histidine kinase, HAMP region; IPR004089: Bacterial chemotaxis sensory transducer; IPR004090: Methyl-accepting chemotaxis protein
YP_216641.1	IPR002625: Smr protein/MutS2 C-terminal
YP_216642.1	IPR001497: Methylated-DNA-[protein]-cysteine S-methyltransferase;protein
YP_216643.2	Global transcription factor that controls the expression of over 100 target genes in response to anoxia
YP_216644.1	with UspC and UspD is involved in resistance to UV irradiation
YP_216646.1	IPR006686: Mechanosensitive (MS) ion channel subdomain
YP_216652.1	IPR000005: Helix-turn-helix, AraC type
YP_216656.1	IPR002198: Short-chain dehydrogenase/reductase SDR; IPR002347: Glucose/ribitol dehydrogenase; IPR003560: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
YP_216657.1	IPR001395: Aldo/keto reductase
YP_216658.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_216661.1	IPR001354: Mandelate racemase/muconate lactonizing enzyme
YP_216662.1	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein
YP_216663.1	regulates genes involved in the biosynthesis and transport of aromatic amino acids
YP_216665.1	IPR007413: YcjX-like protein
YP_216666.1	rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide
YP_216668.1	with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock
YP_216669.1	acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding
YP_216670.1	involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF
YP_216671.2	transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor
YP_216672.1	IPR000914: Bacterial extracellular solute-binding protein, family 5
YP_216675.1	IPR003439: ABC transporter
YP_216676.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_216677.1	IPR001633: EAL domain
YP_216681.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_216683.1	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
YP_216684.1	c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP
YP_216686.1	IPR001034: Bacterial regulatory protein, DeoR family
YP_216688.1	involved in start site selection during the initiation of translation
YP_216689.1	OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_216690.1	IPR001440: TPR repeat
YP_216692.1	IPR000326: PA-phosphatase related phosphoesterase
YP_216693.1	catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate
YP_216694.1	Catalyzes the conversion of citrate to isocitrate
YP_216697.1	LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation
YP_216698.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_216700.1	SohB; periplasmic protein; member of the peptidase S49 family
YP_216701.1	IPR002198: Short-chain dehydrogenase/reductase SDR; IPR002347: Glucose/ribitol dehydrogenase; IPR003560: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
YP_216702.1	catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide
YP_216703.1	catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA
YP_216704.1	IPR004388: Sua5/YciO/YrdC/YwlC
YP_216705.1	IPR003141: Phosphoesterase PHP, N-terminal; IPR004013: PHP domain C-terminal region
YP_216706.1	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine
YP_216707.1	bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis
YP_216708.1	monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate
YP_216709.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_216710.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_216715.1	receptor for colicin S4
YP_216718.1	Involved in cell division; probably involved in intracellular septation
YP_216719.1	YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins
YP_216720.1	membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins
YP_216721.1	unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity
YP_216722.1	catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol)
YP_216723.1	highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein
YP_216724.1	IPR001622: K+ channel, pore region; IPR003091: Voltage-dependent potassium channel; IPR005820: Cation channel, non-ligand gated
YP_216725.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_216726.1	IPR003439: ABC transporter
YP_216727.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_216728.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_216729.1	IPR000914: Bacterial extracellular solute-binding protein, family 5
YP_216731.1	IPR001670: Iron-containing alcohol dehydrogenase
YP_216732.1	catalyzes the formation of thymidine 5'-phosphate from thymidine
YP_216733.1	IPR001801: Histone-like nucleoid-structuring protein H-NS
YP_216734.1	together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose
YP_216735.1	IPR001789: Response regulator receiver
YP_216736.1	IPR001423: Protein of unknown function UPF0028; IPR002641: Patatin
YP_216738.2	produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine
YP_216744.1	IPR000345: Cytochrome c  heme-binding site
YP_216745.1	IPR001005: Myb DNA-binding domain; IPR006655: Prokaryotic molybdopterin oxidoreductase
YP_216747.1	IPR003660: Histidine kinase, HAMP region; IPR005467: Histidine kinase
YP_216748.1	two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase
YP_216751.1	in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions
YP_216753.1	catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis
YP_216754.1	IPR000504: RNA-binding region RNP-1  (RNA recognition motif)
YP_216756.1	HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB
YP_216757.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_216758.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_216759.1	Incorporates lipoproteins in the outer membrane after they are released by the LolA protein
YP_216760.1	An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis
YP_216761.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_216762.1	role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport
YP_216763.1	YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function
YP_216764.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_216765.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_216769.1	IPR001821: Ni-Fe hydrogenase, small subunit
YP_216770.1	IPR000516: Nickel-dependent hydrogenase b-type cytochrome subunit
YP_216771.1	HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1)
YP_216772.1	involved in processing hydrogenases HyaA and HyaB
YP_216774.1	expressed during stationary phase
YP_216775.1	IPR000205: NAD-binding site; IPR000209: Peptidase S8, subtilase serine protease; IPR006095: Glu/Leu/Phe/Val dehydrogenase;IPR006096: Glu/Leu/Phe/Val dehydrogenase, C terminal;IPR006097: Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
YP_216776.1	periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell
YP_216779.1	IPR000189: Prokaryotic transglycosylase, active site
YP_216780.1	catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine
YP_216781.1	the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli
YP_216782.1	catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA
YP_216783.1	catalyzes the oxidative deamination of D-amino acids
YP_216785.1	Multifunctional regulator of fatty acid metabolism
YP_216786.1	involved in regulation of intracellular pH under alkaline conditions
YP_216787.1	disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein
YP_216793.1	IPR007840: Protein of unknown function DUF709
YP_216794.1	blocks the formation of polar Z-ring septums
YP_216795.1	ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums
YP_216796.1	works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell
YP_216797.1	IPR002121: HRDC domain; IPR002562: 3'-5' exonuclease; IPR006292: Ribonuclease D
YP_216798.2	Activates fatty acids by binding to coenzyme A
YP_216802.1	IPR001917: Aminotransferase, class-II
YP_216803.1	IPR006056: YjgF-like protein
YP_216805.1	catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine
YP_216806.1	IPR000059: Protein of unknown function UPF0035
YP_216808.1	IPR001633: EAL domain
YP_216811.1	IPR004720: PTS system sorbose subfamily IIB component
YP_216813.1	hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel
YP_216815.1	membrane protein YebN
YP_216816.1	methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth
YP_216818.1	IPR002059: Cold-shock DNA-binding domain
YP_216820.1	IPR003220: Insertion element protein
YP_216821.1	IPR005063: IS1 transposase
YP_216825.1	IPR005473: Bacterial transcription regulator, ICLR-like family
YP_216826.1	IPR001411: Tetracycline resistance protein TetB; IPR007114: Major facilitator superfamily
YP_216827.1	metalloprotease
YP_216828.1	Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3
YP_216829.1	affects solute and DNA transport through an unknown mechanism
YP_216830.1	IPR003018: GAF domain
YP_216833.2	in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA
YP_216836.2	Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins
YP_216839.1	IPR005414: Salmonella type III secretion SopE effector protein
YP_216842.1	IPR000182: GCN5-related N-acetyltransferase
YP_216855.1	IPR000160: GGDEF
YP_216861.1	similar to phage tail assembly protein
YP_216866.1	IPR000531: TonB-dependent receptor protein
YP_216870.1	3'-5' exonuclease activity on single or double-strand DNA
YP_216871.1	PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues
YP_216873.1	secreted protein; unknown function
YP_216875.1	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis
YP_216876.1	catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate
YP_216877.1	catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate
YP_216878.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_216880.1	Represses the expression of the zwf, eda, glp and gap
YP_216881.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_216884.1	Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA
YP_216886.2	involved in transport of zinc(II) with ZnuA and C
YP_216887.2	involved in transport of zinc(II) with ZnuA and C
YP_216888.1	involved in transport of zinc(II) with ZnuA and C
YP_216889.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_216890.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_216893.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_216894.1	IPR002876: Protein of unknown function DUF28
YP_216895.1	converts dATP to dAMP and pyrophosphate
YP_216896.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_216898.1	IPR002763: Protein of unknown function DUF72
YP_216900.1	IPR000051: SAM (and some other nucleotide) binding motif; IPR001601: Generic methyltransferase
YP_216902.1	IPR002097: Profilin/allergen
YP_216903.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_216907.1	membrane protein involved in the flagellar export apparatus
YP_216908.1	membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export
YP_216909.2	cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation
YP_216910.1	chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble
YP_216911.1	regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins
YP_216912.1	methylates the MCP
YP_216913.1	IPR003660: Histidine kinase, HAMP region; IPR004089: Bacterial chemotaxis sensory transducer; IPR004090: Methyl-accepting chemotaxis protein;IPR004091: Aspartate chemoreceptor protein
YP_216914.1	IPR002545: CheW-like protein
YP_216915.1	chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component
YP_216916.1	with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
YP_216917.1	With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
YP_216918.1	With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems
YP_216919.1	with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems
YP_216921.1	ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress
YP_216923.1	biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature
YP_216925.1	IPR009040: Ferritin-like
YP_216928.1	cytoplasmic iron storage protein
YP_216930.1	IPR002091: Aromatic amino acid permease; IPR002422: Amino acid/polyamine transporter family II
YP_216935.1	IPR000462: CDP-alcohol phosphatidyltransferase
YP_216936.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_216937.1	in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system
YP_216941.1	regulates genes involved in cell division
YP_216942.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_216943.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_216944.1	catalyzes the formation of pyruvate from D-cysteine
YP_216945.1	IPR001311: Solute-binding protein/glutamate receptor; IPR001638: Bacterial extracellular solute-binding protein, family 3
YP_216946.1	expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence
YP_216947.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes
YP_216949.1	structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes
YP_216951.1	involved in flagellin assembly
YP_216952.1	flagellin specific chaperone
YP_216953.1	binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family
YP_216954.1	converts 1,4-alpha-D-glucans to maltodextrin
YP_216957.1	IPR001455: Protein of unknown function UPF0033
YP_216959.1	forms a junction between the M-ring and FlgB during flagella biosynthesis
YP_216961.1	the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod
YP_216962.1	One of three proteins involved in switching the direction of the flagellar rotation
YP_216963.1	binds to and inhibits the function of flagella specific ATPase FliI
YP_216964.1	involved in type III protein export during flagellum assembly
YP_216965.1	rod/hook and filament chaperone
YP_216966.1	IPR001635: Flagellar hook-length control protein
YP_216967.2	interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring
YP_216968.1	with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation
YP_216969.1	One of three proteins involved in switching the direction of the flagellar rotation
YP_216970.1	with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus
YP_216971.1	FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus
YP_216972.1	with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus
YP_216973.1	FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus
YP_216974.1	IPR000792: Bacterial regulatory protein, LuxR family
YP_216977.1	catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate
YP_216978.1	IPR000160: GGDEF
YP_216981.1	IPR004603: DNA mismatch endonuclease vsr
YP_216982.1	IPR001525: C-5 cytosine-specific DNA methylase
YP_216985.1	IPR001702: Porin, Gram-negative type; IPR001897: Porin, bacterial type
YP_216986.1	IPR002059: Cold-shock DNA-binding domain
YP_216987.1	binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization
YP_216988.1	binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization
YP_216990.1	IPR006025: Neutral zinc metallopeptidases, zinc-binding site
YP_217004.1	Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile
YP_217011.1	catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole
YP_217012.1	catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole
YP_217013.1	catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP
YP_217014.1	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
YP_217015.1	IPR003439: ABC transporter
YP_217017.1	periplasmic cobalt binding component of the cobalt transport system
YP_217018.2	catalyzes the ATP-dependent transport of cobalt
YP_217019.1	catalyzes the formation of precorrin-3A from precorrin-2
YP_217020.1	IPR000508: Signal peptidase
YP_217021.1	CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6
YP_217022.1	catalyzes the formation of precorrin-4 from precorrin-3B and S-adenosyl-L-methionine
YP_217023.1	catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3
YP_217024.1	IPR003043: Uroporphiryn-III C-methyltransferase
YP_217025.1	catalyzes the methylation of either C-15 or C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W; decarboxylating
YP_217026.1	catalyzes the methylation of C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W-a
YP_217027.1	Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A
YP_217028.1	catalyzes the interconversion of cobalt-precorrin-8X and cobyrinic acid in the anaerobic biosynthesis of cobalamin
YP_217029.1	CobD; CbiB in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
YP_217030.1	responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid
YP_217031.1	IPR000005: Helix-turn-helix, AraC type
YP_217032.1	IPR000425: MIP family
YP_217033.1	IPR000249: Bacterial microcompartments protein
YP_217035.1	IPR003206: Dehydratase, large subunit
YP_217040.1	IPR000249: Bacterial microcompartments protein
YP_217041.1	IPR000249: Bacterial microcompartments protein
YP_217044.1	IPR004992: Ethanolamine utilization protein EutN/carboxysome structural protein Ccml
YP_217045.1	IPR002779: Protein of unknown function DUF80
YP_217047.1	IPR001670: Iron-containing alcohol dehydrogenase
YP_217048.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_217049.1	IPR000249: Bacterial microcompartments protein
YP_217053.1	involved in coenzyme B(12)-dependent 1, 2-propanediol degradation; important for the synthesis of propionyl coenzyme A during growth on 1,2-propanediol
YP_217054.1	IPR006204: GHMP kinase
YP_217058.1	removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains
YP_217060.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_217061.1	IPR006655: Prokaryotic molybdopterin oxidoreductase
YP_217062.1	orfB
YP_217064.1	Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
YP_217065.1	IPR002293: Amino acid/polyamine transporter family I; IPR004841: Amino acid permease-associated region
YP_217068.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_217069.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_217070.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_217071.1	catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate
YP_217072.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_217073.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide
YP_217074.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_217075.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis
YP_217078.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_217080.1	IPR005841: Phosphoglucomutase/phosphomannomutase
YP_217081.1	IPR001538: Mannose-6-phosphate isomerase, type II; IPR002048: Calcium-binding EF-hand; IPR007113: Cupin domain
YP_217085.1	IPR001064: Beta and gamma crystallin
YP_217086.1	together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose
YP_217087.1	WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid
YP_217091.1	WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid
YP_217092.1	IPR005841: Phosphoglucomutase/phosphomannomutase
YP_217093.1	IPR001538: Mannose-6-phosphate isomerase, type II; IPR005835: Nucleotidyl transferase; IPR006375: Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase;IPR007113: Cupin domain
YP_217096.1	bifunctional protein in colanic acid biosyntheis
YP_217097.1	IPR002198: Short-chain dehydrogenase/reductase SDR
YP_217098.1	acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit)
YP_217099.1	IPR001173: Glycosyl transferase, family 2
YP_217100.1	essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance
YP_217102.1	acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium
YP_217103.1	IPR001173: Glycosyl transferase, family 2
YP_217104.1	Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide)
YP_217105.1	Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis
YP_217106.1	IPR003715: Polysaccharide export protein
YP_217108.1	IPR000644: CBS domain
YP_217109.1	YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs
YP_217110.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_217111.1	functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor
YP_217113.1	IPR000014: PAS domain; IPR000160: GGDEF; IPR000700: PAS-associated, C-terminal;IPR001610: PAC motif;IPR001633: EAL domain;IPR007895: MASE1
YP_217114.1	inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine
YP_217115.1	IPR001023: Heat shock protein Hsp70
YP_217116.1	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate
YP_217117.1	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate
YP_217118.1	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate
YP_217119.1	IPR003660: Histidine kinase, HAMP region; IPR004358: Bacterial sensor protein, C-terminal; IPR005467: Histidine kinase
YP_217120.1	response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport
YP_217132.1	IPR001826: RHS protein
YP_217133.1	IPR006662: Thioredoxin type domain
YP_217138.1	IPR001539: Peptidase U32
YP_217142.1	cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role
YP_217143.1	catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate
YP_217144.1	IPR007114: Major facilitator superfamily
YP_217145.1	IPR005502: ADP-ribosylglycohydrolase
YP_217146.1	IPR002139: Ribokinase; IPR002173: Carbohydrate kinase, PfkB
YP_217147.1	IPR000524: Bacterial regulatory protein, GntR family
YP_217148.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_217149.1	catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP
YP_217152.1	IPR000015: Fimbrial biogenesis outer membrane usher protein
YP_217153.1	IPR001829: Bacterial pili assembly chaperone
YP_217154.1	IPR000504: RNA-binding region RNP-1  (RNA recognition motif)
YP_217156.1	IPR000808: Mrp family
YP_217157.2	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_217161.1	unknown function; when overproduced it confers drug-resistance
YP_217163.1	IPR000551: Bacterial regulatory protein, MerR family
YP_217166.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_217167.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_217169.1	IPR001764: Glycoside hydrolase, family 3, N-terminal; IPR002772: Glycoside hydrolase, family 3, C-terminal
YP_217170.1	component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent
YP_217171.1	specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7
YP_217174.1	IPR002198: Short-chain dehydrogenase/reductase SDR; IPR002347: Glucose/ribitol dehydrogenase; IPR003560: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
YP_217175.1	may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_217178.1	IPR001269: Protein of unknown function UPF0034; IPR003009: FMN/related compound-binding core
YP_217179.1	catalyzes the formation of catechol from salicylate
YP_217180.1	IPR004045: Glutathione S-transferase, N-terminal
YP_217182.1	IPR007113: Cupin domain
YP_217183.1	IPR007114: Major facilitator superfamily
YP_217184.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_217185.1	IPR005538: LrgA family
YP_217187.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_217190.1	function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain
YP_217191.1	catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines
YP_217192.1	ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex
YP_217194.1	negative regulator of the mglBAC operon for galactose utilization
YP_217196.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_217198.1	IPR001387: Helix-turn-helix motif
YP_217199.1	IPR004644: Iron-sulfur-dependent L-serine dehydratase single chain form; IPR005130: Serine dehydratase alpha chain; IPR005131: Serine dehydratase beta chain
YP_217201.1	IPR007114: Major facilitator superfamily
YP_217202.1	Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein
YP_217203.1	IPR002293: Amino acid/polyamine transporter family I; IPR004840: Amino acid permease; IPR004841: Amino acid permease-associated region
YP_217204.1	IPR000792: Bacterial regulatory protein, LuxR family; IPR000847: Bacterial regulatory protein LysR, HTH motif; IPR005119: LysR substrate binding domain
YP_217206.1	Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues
YP_217207.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_217208.1	converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers
YP_217209.1	phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr
YP_217210.1	IPR007114: Major facilitator superfamily
YP_217214.1	Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein
YP_217216.1	IPR000326: PA-phosphatase related phosphoesterase
YP_217217.1	by similarity, Spr seems to have peptidase activity; involved in thermoresistance
YP_217218.1	IPR001633: EAL domain
YP_217219.1	IPR000914: Bacterial extracellular solute-binding protein, family 5
YP_217221.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_217222.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_217225.1	Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance
YP_217226.1	catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA
YP_217227.1	IPR001410: DEAD/DEAH box helicase; IPR001650: Helicase, C-terminal
YP_217228.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_217232.1	IPR000531: TonB-dependent receptor protein
YP_217238.1	nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes
YP_217239.1	IPR001440: TPR repeat; IPR005616: Cytochrome C biogenesis protein
YP_217240.1	IPR004799: Periplasmic protein thiol:disulfide oxidoreductase DsbE; IPR006662: Thioredoxin type domain; IPR006663: Thioredoxin domain 2
YP_217241.1	IPR003567: Cytochrome c-type biogenesis protein; IPR003568: Cytochrome c-type biogenesis protein CcmF
YP_217242.1	CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane
YP_217244.1	IPR002541: Cytochrome c assembly protein; IPR003557: Cytochrome c-type biogenesis protein CcmC
YP_217245.1	IPR003544: Cytochrome c-type biogenesis protein CcmB
YP_217246.1	ATP-binding protein; required for proper cytochrome c maturation
YP_217247.1	with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone
YP_217248.1	small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA
YP_217249.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA
YP_217250.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway
YP_217251.1	periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC
YP_217253.1	serine protease inhibitor, inhibits trypsin and other proteases
YP_217254.1	efflux pump for the antibacterial peptide microcin J25
YP_217256.1	bifunctional; IPR000005: Helix-turn-helix, AraC type; IPR001497: Methylated-DNA-[protein]-cysteine S-methyltransferase;protein,; IPR004026: Metal binding domain of Ada;IPR008332: Methylguanine DNA methyltransferase, ribonuclease-like;protein
YP_217257.1	catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway
YP_217258.1	allows for ions and hydrophilic solutes to cross the outer membrane
YP_217259.1	IPR005467: Histidine kinase; IPR008207: Hpt
YP_217260.1	two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF
YP_217261.1	IPR001789: Response regulator receiver; IPR004358: Bacterial sensor protein, C-terminal; IPR005467: Histidine kinase
YP_217262.1	negatively supercoils closed circular double-stranded DNA
YP_217264.1	IPR007114: Major facilitator superfamily
YP_217266.1	Involved in ubiquinone biosynthesis
YP_217267.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_217268.1	B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA
YP_217269.1	plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases
YP_217270.1	IPR007114: Major facilitator superfamily
YP_217271.1	IPR000847: Bacterial regulatory protein LysR, HTH motif; IPR005119: LysR substrate binding domain
YP_217272.1	hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic
YP_217273.1	catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell
YP_217274.1	anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor
YP_217275.1	sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters
YP_217276.1	anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate
YP_217277.1	similar to ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system
YP_217279.1	IPR005000: HpcH/HpaI aldolase
YP_217280.1	IPR007114: Major facilitator superfamily
YP_217281.1	IPR001354: Mandelate racemase/muconate lactonizing enzyme
YP_217282.1	IPR005473: Bacterial transcription regulator, ICLR-like family
YP_217283.1	IPR001453: Molybdenum cofactor biosynthesis protein
YP_217284.1	IPR000086: NUDIX hydrolase; IPR002667: Isopentenyl-diphosphate delta-isomerase
YP_217286.1	catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose
YP_217287.1	catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate
YP_217289.1	catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A
YP_217292.1	IPR000873: AMP-dependent synthetase and ligase
YP_217293.1	catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate
YP_217294.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_217295.1	catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA
YP_217296.1	SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_217297.1	synthesizes isochorismate acid from chorismate
YP_217300.2	member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions
YP_217301.1	IPR001789: Response regulator receiver; IPR002545: CheW-like protein
YP_217302.1	IPR002035: von Willebrand factor, type A
YP_217303.1	Catalyzes the transfer of electrons from NADH to quinone
YP_217304.1	Catalyzes the transfer of electrons from NADH to quinone
YP_217305.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_217306.1	Catalyzes the transfer of electrons from NADH to quinone
YP_217307.1	Catalyzes the transfer of electrons from NADH to quinone
YP_217308.1	Catalyzes the transfer of electrons from NADH to quinone
YP_217309.1	Catalyzes the transfer of electrons from NADH to quinone
YP_217310.1	Catalyzes the transfer of electrons from NADH to quinone
YP_217311.1	shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase
YP_217312.1	Catalyzes the transfer of electrons from NADH to quinone
YP_217313.1	NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms
YP_217314.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_217315.1	Catalyzes the transfer of electrons from NADH to quinone
YP_217317.1	IPR000169: Eukaryotic thiol (cysteine) protease; IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_217319.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_217321.1	IPR001898: Sodium/sulphate symporter
YP_217322.2	IPR005833: Haloacid dehalogenase/epoxide hydrolase
YP_217323.1	IPR005587: YfbU
YP_217325.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_217326.1	catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate
YP_217327.1	IPR006162: Phosphopantetheine attachment site
YP_217330.2	membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr
YP_217332.1	IPR002178: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
YP_217333.1	IPR000843: Bacterial regulatory protein LacI, HTH motif
YP_217334.1	IPR002667: Isopentenyl-diphosphate delta-isomerase
YP_217335.1	IPR000979: Protein of unknown function UPF0025; IPR004843: Metallo-phosphoesterase
YP_217336.1	IPR004045: Glutathione S-transferase, N-terminal
YP_217337.1	IPR004045: Glutathione S-transferase, N-terminal; IPR004046: Glutathione S-transferase, C-terminal
YP_217339.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter; IPR003593: AAA ATPase
YP_217340.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_217341.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_217342.1	IPR001311: Solute-binding protein/glutamate receptor; IPR001638: Bacterial extracellular solute-binding protein, family 3
YP_217343.1	IPR001311: Solute-binding protein/glutamate receptor; IPR001638: Bacterial extracellular solute-binding protein, family 3
YP_217345.1	catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate
YP_217346.1	IPR002293: Amino acid/polyamine transporter family I
YP_217348.1	IPR002293: Amino acid/polyamine transporter family I
YP_217349.1	IPR000183: Orn/DAP/Arg decarboxylase 2
YP_217350.1	IPR000014: PAS domain; IPR002078: Sigma-54 factor interaction domain; IPR002197: Helix-turn-helix, Fis-type
YP_217351.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_217352.1	membrane protein required for colicin V production
YP_217353.1	IPR000694: Proline-rich region
YP_217354.1	IPR001645: Folylpolyglutamate synthetase
YP_217355.2	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_217356.1	IPR000252: DedA family
YP_217357.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_217359.1	catalyzes the formation of 3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate from erythronate-4-phosphate
YP_217360.2	in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein
YP_217361.1	IPR007114: Major facilitator superfamily
YP_217367.1	FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_217368.2	catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules
YP_217372.1	D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm
YP_217373.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_217374.1	involved in methylation of ribosomal protein L3
YP_217375.1	IPR002625: Smr protein/MutS2 C-terminal
YP_217377.1	multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate
YP_217378.1	FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth
YP_217379.1	IPR005272: Conserved hypothetical protein 743
YP_217380.1	IPR005017: Membrane protein involved in aromatic hydrocarbon degradation
YP_217383.1	outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA
YP_217384.1	IPR001789: Response regulator receiver; IPR002078: Sigma-54 factor interaction domain; IPR002197: Helix-turn-helix, Fis-type
YP_217385.1	IPR003660: Histidine kinase, HAMP region; IPR005467: Histidine kinase
YP_217387.1	IPR000849: GlpT transporter; IPR007114: Major facilitator superfamily
YP_217389.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock
YP_217393.1	catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate
YP_217394.1	IPR001807: Cl- channel, voltage gated
YP_217395.1	IPR000399: Pyruvate decarboxylase; IPR000408: Regulator of chromosome condensation, RCC1
YP_217396.1	IPR001395: Aldo/keto reductase; IPR005399: KCNAB voltage-gated K+ channel, beta subunit
YP_217398.1	IPR001046: Natural resistance-associated macrophage protein
YP_217399.1	IPR002668: Na+ dependent nucleoside transporter
YP_217400.1	IPR001633: EAL domain
YP_217403.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_217404.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_217406.1	IPR004740: Nucleoside:H+ symporter; IPR007114: Major facilitator superfamily
YP_217407.1	catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation
YP_217409.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_217412.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_217413.1	interacts with cell division protein FitsZ and may be required to anchor septal ring structure
YP_217414.1	role in sulfur assimilation
YP_217415.1	CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis
YP_217416.1	IPR000032: Phosphocarrier HPr protein; IPR001020: HPr histidine phosphorylation site; IPR002114: HPr serine phosphorylation site
YP_217417.1	Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system
YP_217418.1	functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose
YP_217419.1	IPR002086: Aldehyde dehydrogenase
YP_217420.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_217421.1	IPR000524: Bacterial regulatory protein, GntR family
YP_217422.1	Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group
YP_217426.2	catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide
YP_217427.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_217428.1	Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import
YP_217429.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_217430.1	IPR000957: Prokaryotic sulfate-/thiosulfate-binding protein; IPR002052: N-6 Adenine-specific DNA methylase
YP_217431.1	IPR002198: Short-chain dehydrogenase/reductase SDR; IPR002347: Glucose/ribitol dehydrogenase; IPR002424: Insect alcohol dehydrogenase family;IPR003560: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
YP_217437.1	catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis
YP_217440.1	activates the transcription of the ethanolamine utilization operon
YP_217444.1	IPR001670: Iron-containing alcohol dehydrogenase
YP_217445.1	IPR001023: Heat shock protein Hsp70
YP_217447.1	IPR004992: Ethanolamine utilization protein EutN/carboxysome structural protein Ccml
YP_217448.1	IPR000249: Bacterial microcompartments protein
YP_217449.1	in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta
YP_217452.1	IPR001687: ATP/GTP-binding site motif A (P-loop)
YP_217454.1	NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate
YP_217456.1	Maintains the balance of metabolites in the pentose-phosphate pathway
YP_217457.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_217458.1	IPR000345: Cytochrome c  heme-binding site
YP_217462.1	unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)
YP_217463.1	IPR001036: Acriflavin resistance protein
YP_217465.1	dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.
YP_217468.1	IPR006025: Neutral zinc metallopeptidases, zinc-binding site
YP_217469.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_217470.1	IPR001360: Glycoside hydrolase, family 1
YP_217471.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_217472.2	negative transcriptional regulator of the gcvTHP operon
YP_217473.1	bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine
YP_217474.1	IPR004381: Conserved hypothetical protein 45
YP_217478.1	IPR001440: TPR repeat
YP_217480.1	controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP
YP_217481.1	IPR006042: Xanthine/uracil permease family
YP_217482.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_217483.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_217484.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_217485.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_217487.1	IPR001633: EAL domain
YP_217491.1	IPR002453: Beta tubulin
YP_217492.1	IPR000345: Cytochrome c  heme-binding site
YP_217495.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_217496.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_217497.2	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_217498.1	IPR008541: Salmonella Protein of unknown function DUF823; IPR008542: Salmonella Protein of unknown function DUF824
YP_217501.1	IPR003535: Intimin bacterial adhesion mediator protein
YP_217503.1	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_217504.1	with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis
YP_217506.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_217507.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_217509.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_217510.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_217511.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_217513.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_217514.1	IPR006655: Prokaryotic molybdopterin oxidoreductase
YP_217515.1	catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds
YP_217517.1	enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I
YP_217518.2	catalyzes the removal of an N-terminal amino acid from a peptide or arylamide
YP_217520.1	IPR001055: Adrenodoxin
YP_217521.1	J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins
YP_217522.1	forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein
YP_217524.1	catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis
YP_217525.1	regulates the expression of the iscRSUA operon
YP_217527.1	IPR000760: Inositol monophosphatase
YP_217528.1	IPR000379: Esterase/lipase/thioesterase
YP_217529.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_217530.1	with AsrAC catalyzes the reduction of sulfite to hydrogen sulfide
YP_217531.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain; IPR006066: Nitrite and sulfite reductase iron-sulfur/siroheme-binding site
YP_217535.1	transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters
YP_217536.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_217538.1	flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine
YP_217539.1	regulates the cadBA operon
YP_217540.1	antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein
YP_217541.1	IPR000310: Orn/Lys/Arg decarboxylase, major region; IPR005308: Orn/Lys/Arg decarboxylase, N-terminal domain; IPR008286: Orn/Lys/Arg decarboxylase, C-terminal
YP_217542.1	IPR000109: TGF-beta receptor, type I/II extracellular region; IPR001092: Basic helix-loop-helix dimerization domain bHLH; IPR007114: Major facilitator superfamily
YP_217543.1	indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA
YP_217544.1	IPR001789: Response regulator receiver; IPR002078: Sigma-54 factor interaction domain; IPR002197: Helix-turn-helix, Fis-type
YP_217546.1	IPR003594: ATP-binding region, ATPase-like; IPR003660: Histidine kinase, HAMP region; IPR003661: Histidine kinase A, N-terminal;IPR004358: Bacterial sensor protein, C-terminal;IPR005467: Histidine kinase
YP_217547.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_217549.1	YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function
YP_217550.1	IPR002125: Cytidine/deoxycytidylate deaminase, zinc-binding region
YP_217552.1	IPR001996: Phosphotransferase system PTS, EIIB domain
YP_217553.1	catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway
YP_217555.1	catalyzes the formation of 2-dehydropantoate from (R)-pantoate
YP_217556.1	IPR007114: Major facilitator superfamily
YP_217557.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_217558.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_217559.1	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids
YP_217560.1	involved in the de novo synthesis of pyridoxine (Vitamin B6)
YP_217561.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_217562.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_217563.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_217564.1	catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins
YP_217565.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_217568.1	similar to genes in P2-like phages
YP_217569.1	similar to invertase (pin) in phage E14
YP_217578.1	IPR005569: Arc-like DNA binding domain
YP_217601.1	IPR002196: Glycoside hydrolase, family 24
YP_217603.1	IPR006025: Neutral zinc metallopeptidases, zinc-binding site
YP_217606.1	IPR000345: Cytochrome c  heme-binding site; IPR003222: Antitermination protein
YP_217618.1	acts to load the DnaB helicase onto the intiation site durning DNA replication
YP_217619.1	similar to replication protein 15; IPR006497: Phage replication protein O, N-terminal
YP_217620.1	similar to cI protein in phage N
YP_217621.1	IPR001387: Helix-turn-helix motif
YP_217625.1	similar to exodeoxyribonuclease VIII
YP_217628.1	similar to integrase in phage
YP_217629.1	involved in the reduction of the SoxR iron-sulfur cluster
YP_217630.1	periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP
YP_217632.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_217633.1	catalyzes the formation of oxaloacetate from L-aspartate
YP_217634.1	IPR000051: SAM (and some other nucleotide) binding motif; IPR002052: N-6 Adenine-specific DNA methylase
YP_217635.1	facilitates an early step in the assembly of the 50S subunit of the ribosome
YP_217636.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_217637.1	IPR001123: Lysine exporter protein (LYSE/YGGA)
YP_217638.1	stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit
YP_217639.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_217640.1	IPR001537: tRNA/rRNA methyltransferase (SpoU)
YP_217641.1	IPR006662: Thioredoxin type domain; IPR006663: Thioredoxin domain 2
YP_217644.1	catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome
YP_217646.1	IPR005829: Sugar transporter superfamily; IPR007114: Major facilitator superfamily
YP_217650.1	IPR001270: Chaperonin clpA/B
YP_217652.1	responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA
YP_217653.1	with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline
YP_217655.1	associated with 30S ribosomal subunit; interferes with translation elongation
YP_217656.1	catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis
YP_217658.1	catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis
YP_217659.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive
YP_217661.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_217662.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_217663.2	Essential for efficient processing of 16S rRNA
YP_217664.2	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_217665.1	with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins
YP_217667.2	IPR000644: CBS domain
YP_217670.2	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_217669.2	catalyzes the phosphorylation of NAD to NADP
YP_217671.1	IPR003439: ABC transporter
YP_217672.1	IPR001993: Mitochondrial substrate carrier; IPR002048: Calcium-binding EF-hand; IPR007450: SmpA/OmlA
YP_217674.1	IPR004827: Basic-leucine zipper (bZIP) transcription factor; IPR005340: Protein of unknown function UPF0083
YP_217675.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_217680.1	IPR003423: Outer membrane efflux protein
YP_217681.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_217682.1	IPR001064: Beta and gamma crystallin; IPR003997: Gram-negative bacterial RTX secretion protein D; IPR006144: HlyD secretion protein, C-terminal
YP_217684.1	IPR002197: Helix-turn-helix, Fis-type; IPR002514: Transposase, IS3/IS911family
YP_217685.1	IPR001584: Integrase, catalytic domain
YP_217686.1	IPR000123: RNA-directed DNA polymerase (Reverse transcriptase), msDNA
YP_217688.1	IPR003223: Flagellin phase1 repressor
YP_217689.1	H inversion: regulation of flagellar gene expression by site-specific inversion of DNA; IPR006118: Site-specific recombinase
YP_217691.1	IPR001993: Mitochondrial substrate carrier
YP_217692.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_217695.2	Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space
YP_217702.1	IPR001064: Beta and gamma crystallin; IPR003594: ATP-binding region, ATPase-like; IPR003660: Histidine kinase, HAMP region;IPR003661: Histidine kinase A, N-terminal;IPR004358: Bacterial sensor protein, C-terminal;IPR005467: Histidine kinase
YP_217703.1	IPR001789: Response regulator receiver; IPR001867: Transcriptional regulatory protein, C terminal; IPR005829: Sugar transporter superfamily
YP_217705.1	IPR005064: Uncharacterized protein family UPF0065
YP_217707.1	IPR002823: Protein of unknown function DUF112
YP_217708.2	in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution
YP_217709.1	catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate
YP_217710.1	catalyzes the formation of succinate from succinate semialdehyde; NADP dependent
YP_217711.1	catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate
YP_217712.1	IPR002293: Amino acid/polyamine transporter family I; IPR004840: Amino acid permease; IPR004841: Amino acid permease-associated region
YP_217713.1	regulator of gab gene expression
YP_217714.1	IPR002482: Peptidoglycan-binding LysM; IPR007055: Transport-associated domain
YP_217715.1	IPR000612: Protein of unknown function UPF0057
YP_217716.1	IPR000485: Bacterial regulatory proteins, AsnC/Lrp; IPR001845: Bacterial regulatory protein, ArsR family
YP_217717.1	IPR000010: Cysteine protease inhibitor; IPR001763: Rhodanese-like
YP_217719.1	IPR001801: Histone-like nucleoid-structuring protein H-NS
YP_217723.1	IPR000524: Bacterial regulatory protein, GntR family
YP_217724.1	IPR003779: Carboxymuconolactone decarboxylase; IPR004675: Alkylhydroperoxidase AhpD core domain
YP_217726.1	IPR000345: Cytochrome c  heme-binding site
YP_217727.1	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF
YP_217728.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_217729.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_217730.1	with ProWX is involved in the high-affinity uptake of glycine betaine
YP_217731.1	with ProVX is involved in the high-affinity uptake of glycine betaine
YP_217732.1	with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine
YP_217733.1	IPR005828: General substrate transporter; IPR007114: Major facilitator superfamily
YP_217734.1	DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB
YP_217735.1	IPR005694: Efflux pump membrane protein Emr; IPR006143: Secretion protein HlyD
YP_217736.1	IPR004638: Drug resistance transporter EmrB/QacA subfamily; IPR005828: General substrate transporter; IPR007114: Major facilitator superfamily
YP_217739.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_217740.1	involved in the first step of glutathione biosynthesis
YP_217742.1	YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent
YP_217746.1	affects carbohydrate metabolism; has regulatory role in many processes
YP_217747.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_217748.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_217749.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_217750.1	IPR008136: CinA, C-terminal
YP_217751.1	membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan
YP_217752.1	IPR004699: PTS system enzyme II sorbitol-specific factor
YP_217753.1	IPR000719: Protein kinase; IPR004702: Sorbitol phosphotransferase enzyme II
YP_217754.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_217755.1	catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate
YP_217756.1	regulator for glucitol utilization
YP_217757.1	regulates genes involved in glucitol utilization
YP_217758.1	catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate
YP_217759.1	Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon
YP_217760.1	detoxifies nitric oxide using NADH
YP_217761.1	catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase
YP_217762.1	IPR001792: Acylphosphatase; IPR004421: Hydrogenase maturation protein HypF; IPR006070: SUA5/yciO/yrdC, N-terminal;IPR006071: SUA5/yciO/yrdC
YP_217763.1	involved in electron transport from formate to hydrogen
YP_217765.1	involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE
YP_217767.1	IPR006137: NADH ubiquinone oxidoreductase domain, 20 kDa subunit; IPR006138: NADH dehydrogenase (ubiquinone), 20 kDa subunit
YP_217768.1	electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate
YP_217769.1	IPR001135: NADH-ubiquinone oxidoreductase, chain 49kDa; IPR001268: NADH dehydrogenase (ubiquinone), 30 kDa subunit
YP_217770.1	IPR001694: Respiratory-chain NADH dehydrogenase, subunit 1
YP_217771.1	catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3)
YP_217772.1	IPR000345: Cytochrome c  heme-binding site; IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_217773.1	regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon
YP_217774.1	plays a role in hydrogenase nickel cofactor insertion
YP_217775.1	GTP hydrolase involved in nickel liganding into hydrogenases
YP_217776.1	HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase
YP_217777.1	IPR002780: Hydrogenase formation HypD protein
YP_217778.1	IPR000728: AIR synthase related protein
YP_217779.1	IPR002078: Sigma-54 factor interaction domain; IPR002197: Helix-turn-helix, Fis-type; IPR003018: GAF domain;IPR003593: AAA ATPase
YP_217781.1	IPR006127: Periplasmic solute binding protein; IPR006128: Adhesion lipoprotein; IPR006129: Adhesin B
YP_217782.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter; IPR003593: AAA ATPase
YP_217783.1	IPR001626: ABC transporter family 3
YP_217784.1	IPR001626: ABC transporter family 3
YP_217785.1	IPR000792: Bacterial regulatory protein, LuxR family
YP_217786.1	IPR000005: Helix-turn-helix, AraC type
YP_217790.1	IPR003282: Type III secretion system outer membrane K protein; IPR006182: Secretory protein YscJ/FliF
YP_217794.1	IPR000005: Helix-turn-helix, AraC type
YP_217795.1	Activates the expression of invasion genes and activates the expression of prgHIJK which is part of the pathogenicity island 1 type III secretion system
YP_217796.1	IPR008258: SLT domain
YP_217797.1	IPR000242: Tyrosine specific protein phosphatase; IPR000387: Tyrosine specific protein phosphatase and dual specificity protein phosphatase; IPR003537: Yersinia virulence determinant YopE;IPR003546: Salmonella/Yersinia modular tyrosine phosphatase;IPR003595: Protein tyrosine phosphatase, catalytic region
YP_217800.1	carries the fatty acid chain in fatty acid biosynthesis
YP_217803.1	IPR005427: Salmonella/Shigella invasin protein C
YP_217804.1	IPR003895: Salmonella/Shigella invasin protein B
YP_217805.1	IPR005415: Gram-negative bacterial type III secretion SycD chaperone
YP_217806.1	Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins
YP_217807.1	IPR002010: Bacterial export protein, family 1; IPR006304: Type III secretion protein SpaR/YscT
YP_217808.1	IPR000595: Cyclic nucleotide-binding domain; IPR002191: Bacterial export protein FliQ, family 3; IPR006306: Type III secretion protein HrpO
YP_217809.1	part of a type III secretory system probably involved in invasion into eukaryotic cells
YP_217810.1	involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells
YP_217811.1	IPR003066: Salmonella invasion protein InvJ
YP_217812.1	IPR002954: Salmonella surface presentation of antigen M protein
YP_217813.1	Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase
YP_217814.1	IPR003065: Invasion protein, B family
YP_217815.1	IPR001712: Bacterial type III secretion FHIPEP; IPR006302: Type III secretion protein HrcV
YP_217816.1	IPR003520: Salmonella/Shigella invasion protein E
YP_217817.1	IPR001775: Bacterial general secretion pathway protein D; IPR003522: Type III secretion system outer membrane G protein; IPR004845: Bacterial type II secretion system protein D;IPR004846: Bacterial type II and III secretion system protein;IPR005644: NolW-like
YP_217818.1	IPR000005: Helix-turn-helix, AraC type
YP_217819.1	IPR006830: InvH outer membrane lipoprotein
YP_217821.1	IPR000182: GCN5-related N-acetyltransferase
YP_217823.1	IPR004843: Metallo-phosphoesterase; IPR006186: Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
YP_217828.1	This protein performs the mismatch recognition step during the DNA repair process
YP_217830.1	IPR003474: Gluconate transporter
YP_217833.1	IPR001303: Class II aldolase/adducin, N-terminal
YP_217835.1	IPR002204: 3-hydroxyisobutyrate dehydrogenase
YP_217836.1	IPR001034: Bacterial regulatory protein, DeoR family
YP_217837.1	IPR000835: Bacterial regulatory protein, MarR family
YP_217838.1	IPR003382: Flavoprotein; IPR004507: Phenylacrylic acid decarboxylase, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
YP_217839.1	IPR002830: Carboxylyase-related protein
YP_217841.1	IPR001584: Integrase, catalytic domain
YP_217843.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses
YP_217844.1	outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus
YP_217845.1	catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins
YP_217846.1	catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate
YP_217847.1	catalyzes the modification of U13 in tRNA(Glu)
YP_217848.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_217849.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_217850.1	forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein
YP_217852.1	converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis
YP_217853.1	may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ
YP_217854.1	with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP
YP_217855.1	catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3
YP_217864.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_217865.1	hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide
YP_217866.1	catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity
YP_217867.1	IPR007115: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; IPR007116: 6-pyruvoyl tetrahydropterin synthase
YP_217868.1	IPR001279: Beta-lactamase-like
YP_217870.1	IPR001584: Integrase, catalytic domain
YP_217873.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_217874.1	CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_217875.1	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era
YP_217876.1	IPR000259: Fimbrial protein
YP_217877.1	IPR000015: Fimbrial biogenesis outer membrane usher protein
YP_217878.1	IPR001829: Bacterial pili assembly chaperone
YP_217879.1	IPR000259: Fimbrial protein
YP_217880.1	IPR000259: Fimbrial protein
YP_217881.1	IPR000259: Fimbrial protein
YP_217883.1	(p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP
YP_217884.1	in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]
YP_217885.1	part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system
YP_217886.1	IPR004381: Conserved hypothetical protein 45
YP_217887.1	IPR001354: Mandelate racemase/muconate lactonizing enzyme
YP_217888.1	IPR004744: D-galactonate transporter; IPR005828: General substrate transporter; IPR007114: Major facilitator superfamily
YP_217890.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_217891.1	catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp
YP_217892.1	IPR007384: Protein of unknown function DUF446
YP_217893.1	SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function
YP_217894.1	catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis
YP_217895.1	IPR005269: Conserved hypothetical protein 730
YP_217896.1	IPR002091: Aromatic amino acid permease; IPR002422: Amino acid/polyamine transporter family II; IPR004694: Serine transporter
YP_217897.1	IPR004644: Iron-sulfur-dependent L-serine dehydratase single chain form; IPR005130: Serine dehydratase alpha chain; IPR005131: Serine dehydratase beta chain
YP_217898.1	has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups
YP_217899.1	IPR001670: Iron-containing alcohol dehydrogenase
YP_217900.1	catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate
YP_217902.1	IPR005275: L-fucose permease; IPR005828: General substrate transporter; IPR007114: Major facilitator superfamily
YP_217903.1	catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose
YP_217904.1	IPR000577: Carbohydrate kinase, FGGY
YP_217905.1	IPR007721: RbsD or FucU transport
YP_217906.1	regulates expression of genes involved in L-fucose utilization
YP_217908.1	IPR006696: Protein of unknown function DUF423
YP_217909.1	Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence
YP_217911.1	IPR000192: Aminotransferase, class V
YP_217912.1	IPR003808: Protein of unknown function UPF0050
YP_217913.1	IPR000620: Protein of unknown function DUF6; IPR004626: RarD protein
YP_217914.1	IPR000205: NAD-binding site; IPR000594: UBA/THIF-type NAD/FAD binding fold
YP_217915.1	membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_217916.1	IPR002508: Cell wall hydrolase/autolysin; IPR006311: Twin-arginine translocation pathway signal
YP_217917.1	catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis
YP_217918.1	helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
YP_217919.1	helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
YP_217920.1	IPR001431: Peptidase M16, insulinase-like; IPR007863: Peptidase M16 inactive
YP_217921.1	catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination
YP_217922.1	IPR001120: Prokaryotic N-terminal methylation site
YP_217924.1	IPR001120: Prokaryotic N-terminal methylation site
YP_217925.1	IPR001120: Prokaryotic N-terminal methylation site
YP_217927.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_217928.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_217929.1	member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr
YP_217930.1	hydrolyzes diadenosine polyphosphate
YP_217931.1	MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair
YP_217932.1	IPR005496: Integral membrane protein TerC family
YP_217934.1	complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH
YP_217936.1	Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1
YP_217937.1	controls transcription of galETKM
YP_217938.1	IPR000843: Bacterial regulatory protein LacI, HTH motif; IPR001761: Periplasmic binding protein/LacI transcriptional regulator
YP_217939.1	catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding
YP_217940.1	activates the transcription of the lysA gene encoding diaminopimelate decarboxylase
YP_217941.1	IPR001920: Asp/Glu racemase; IPR004380: Aspartate racemase
YP_217942.1	IPR003663: Sugar transporter; IPR005828: General substrate transporter; IPR005829: Sugar transporter superfamily;IPR007114: Major facilitator superfamily
YP_217943.1	catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate
YP_217944.1	4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
YP_217945.2	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis
YP_217947.1	IPR007896: Bacterial transmembrane pair
YP_217948.1	IPR002091: Aromatic amino acid permease; IPR002422: Amino acid/polyamine transporter family II
YP_217949.1	IPR003735: Protein of unknown function DUF156
YP_217954.1	IPR001829: Bacterial pili assembly chaperone
YP_217955.1	IPR000015: Fimbrial biogenesis outer membrane usher protein
YP_217956.1	IPR000259: Fimbrial protein
YP_217958.1	IPR000758: Virulence-related outer membrane protein
YP_217960.1	stability determinant protein
YP_217961.1	IPR007159: SpoVT/AbrB-like domain
YP_217965.1	IPR002482: Peptidoglycan-binding LysM; IPR002886: Peptidase  M23/M37
YP_217966.1	catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate
YP_217967.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_217968.1	IPR000352: Class I peptide chain release factor domain; IPR004374: Peptide chain release factor 2; IPR005139: PCRF domain
YP_217969.1	5'-3' single-stranded-DNA-specific exonuclease
YP_217970.1	DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity
YP_217971.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_217972.2	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic
YP_217974.1	IPR005631: Protein of unknown function DUF339
YP_217976.1	physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator
YP_217977.1	IPR004254: Hly-III related proteins; IPR005744: HylII
YP_217979.1	IPR001360: Glycoside hydrolase, family 1
YP_217981.2	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_217982.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_217983.1	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_217984.1	IPR000205: NAD-binding site; IPR000689: UbiH/COQ6 monooxygenase; IPR000733: Flavoprotein monooxygenase;IPR003042: Aromatic-ring hydroxylase
YP_217985.1	Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone
YP_217986.1	exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide
YP_217987.2	the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown
YP_217988.1	IPR007838: Protein of unknown function DUF710
YP_217989.2	ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function
YP_217990.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_217991.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_217992.1	specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport
YP_217994.1	IPR007497: Protein of unknown function DUF541
YP_217995.1	Involved in the export of arginine
YP_217996.1	participates in the regulation of osmotic pressure changes within the cel
YP_217997.2	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_217998.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_217999.1	NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate
YP_218000.1	IPR005175: Protein of unknown function DUF296
YP_218003.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter; IPR003593: AAA ATPase
YP_218004.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter; IPR003593: AAA ATPase
YP_218005.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_218006.1	IPR001915: Peptidase M48
YP_218007.1	catalyzes the formation of putrescine from agmatine
YP_218008.1	IPR004375: Conserved hypothetical protein 22
YP_218009.1	IPR003767: Malate/L-lactate dehydrogenase
YP_218010.1	IPR000205: NAD-binding site; IPR002085: Zinc-containing alcohol dehydrogenase superfamily; IPR002328: Zinc-containing alcohol dehydrogenase
YP_218011.1	IPR000524: Bacterial regulatory protein, GntR family
YP_218013.1	catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis
YP_218017.1	methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_218018.1	IPR003663: Sugar transporter; IPR005828: General substrate transporter; IPR005829: Sugar transporter superfamily;IPR007114: Major facilitator superfamily
YP_218019.1	IPR005622:  metallopeptidase (SprT family); IPR006025: Neutral zinc metallopeptidases, zinc-binding site; IPR006640: SprT
YP_218020.1	IPR007346: Endonuclease I
YP_218021.2	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_218022.1	catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
YP_218023.2	IPR003774: Protein of unknown function DUF179
YP_218024.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_218025.1	IPR005471: Bacterial regulatory proteins, IclR family
YP_218026.1	IPR001482: Bacterial type II secretion system protein E; IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003593: AAA ATPase;IPR006321: Pilus retraction protein PilT
YP_218027.1	IPR001608: Protein of unknown function UPF0001
YP_218028.1	IPR003425: Protein of unknown function YGGT
YP_218029.2	IPR003746: Protein of unknown function DUF167; IPR005228: Conserved hypothetical protein 251
YP_218030.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_218031.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_218033.1	catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis
YP_218036.1	IPR007416: Protein with unknown function DUF469
YP_218037.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_218038.1	IPR000445: Helix-hairpin-helix motif; IPR003265: HhH-GPD; IPR003651: Iron-sulfur cluster loop;IPR004035: Endonuclease III, FCL;IPR004036: Endonuclease III, HhH;IPR005760: A/G-specific adenine glycosylase MutY
YP_218039.1	IPR007457: Protein of unknown function DUF495
YP_218040.1	Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_218041.1	IPR004740: Nucleoside:H+ symporter; IPR007114: Major facilitator superfamily
YP_218042.2	IPR000310: Orn/Lys/Arg decarboxylase, major region; IPR005308: Orn/Lys/Arg decarboxylase, N-terminal domain; IPR008286: Orn/Lys/Arg decarboxylase, C-terminal
YP_218043.1	IPR007563: Protein of unknown function DUF554
YP_218044.1	IPR004360: Glyoxalase/Bleomycin resistance protein/dioxygenase domain
YP_218045.1	IPR003702: Acetyl-CoA hydrolase/transferase
YP_218046.1	IPR002539: MaoC-like dehydratase
YP_218047.1	IPR001064: Beta and gamma crystallin
YP_218048.1	IPR000847: Bacterial regulatory protein LysR, HTH motif; IPR005119: LysR substrate binding domain
YP_218049.1	IPR000917: Sulfatase
YP_218050.1	IPR007197: Radical SAM
YP_218051.1	IPR000792: Bacterial regulatory protein, LuxR family
YP_218053.1	IPR002293: Amino acid/polyamine transporter family I; IPR004841: Amino acid permease-associated region
YP_218054.1	IPR007113: Cupin domain; IPR008579: Protein of unknown function DUF861
YP_218055.1	IPR000205: NAD-binding site; IPR000408: Regulator of chromosome condensation, RCC1
YP_218056.1	IPR002086: Aldehyde dehydrogenase
YP_218057.1	inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS
YP_218058.1	IPR008514: Protein of unknown function DUF796
YP_218060.1	IPR002509: Polysaccharide deacetylase
YP_218061.1	IPR000276: Rhodopsin-like GPCR superfamily; IPR003010: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase
YP_218062.1	IPR005828: General substrate transporter; IPR007114: Major facilitator superfamily
YP_218063.1	catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate
YP_218064.1	IPR000669: Mannitol dehydrogenase; IPR001993: Mitochondrial substrate carrier
YP_218065.1	catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism
YP_218066.1	IPR004089: Bacterial chemotaxis sensory transducer; IPR004090: Methyl-accepting chemotaxis protein
YP_218067.1	catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction
YP_218068.1	YghU; B2989; one of eight  glutathione transferases from E. coli
YP_218070.1	IPR002491: Periplasmic binding protein
YP_218071.1	IPR001109: Hydrogenase expression/formation protein (HUPF/HYPC)
YP_218072.1	plays a role in hydrogenase nickel cofactor insertion
YP_218074.1	protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC)
YP_218075.1	involved in hydrogen uptake
YP_218076.1	HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits
YP_218077.1	Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2
YP_218078.1	involved in hydrogen uptake
YP_218081.1	IPR003660: Histidine kinase, HAMP region; IPR004089: Bacterial chemotaxis sensory transducer; IPR004090: Methyl-accepting chemotaxis protein;IPR004091: Aspartate chemoreceptor protein
YP_218082.1	IPR005134: Uncharacterized protein family UPF0114
YP_218086.1	IPR002198: Short-chain dehydrogenase/reductase SDR; IPR002347: Glucose/ribitol dehydrogenase; IPR003560: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
YP_218087.1	membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell
YP_218088.1	membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell
YP_218091.1	IPR001584: Integrase, catalytic domain
YP_218092.1	catalyzes the formation of L-homocysteine from cystathionine
YP_218093.1	IPR000252: DedA family
YP_218094.1	IPR000005: Helix-turn-helix, AraC type
YP_218095.1	IPR001670: Iron-containing alcohol dehydrogenase
YP_218096.1	methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate
YP_218097.1	IPR001898: Sodium/sulphate symporter
YP_218098.1	IPR001310: Histidine triad (HIT) protein
YP_218099.1	IPR005839: Protein of unknown function UPF0004; IPR006638: Elongator protein 3/MiaB/NifB; IPR007197: Radical SAM
YP_218100.1	IPR004682: TRAP dicarboxylate transporter- DctP subunit
YP_218101.1	IPR007387: Tripartite ATP-independent periplasmic transporters, DctQ component
YP_218102.1	IPR000252: DedA family; IPR004681: TRAP dicarboxylate transporter DctM subunit
YP_218103.1	IPR001117: Multicopper oxidase, type 1; IPR006311: Twin-arginine translocation pathway signal
YP_218104.1	IPR002123: Phospholipid/glycerol acyltransferase; IPR004552: 1-acyl-sn-glycerol-3-phosphate acyltransferase
YP_218105.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_218106.1	IPR000005: Helix-turn-helix, AraC type
YP_218107.1	IPR005220: Conserved hypothetical protein 156
YP_218108.1	response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes
YP_218109.1	IPR003594: ATP-binding region, ATPase-like; IPR003660: Histidine kinase, HAMP region; IPR003661: Histidine kinase A, N-terminal;IPR004358: Bacterial sensor protein, C-terminal;IPR005467: Histidine kinase
YP_218110.1	IPR003680: NAD(P)H dehydrogenase (quinone)
YP_218111.1	IPR005479: Carbamoyl-phosphate synthase L chain, ATP-binding; IPR007138: Antibiotic biosynthesis monooxygenase
YP_218112.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_218113.1	Displays esterase activity toward palmitoyl-CoA and pNP-butyrate
YP_218114.1	IPR004843: Metallo-phosphoesterase
YP_218116.1	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_218117.2	trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell
YP_218119.1	IPR005494: Glutathionylspermidine synthase
YP_218120.1	seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine
YP_218121.1	IPR003689: Zinc transporter ZIP
YP_218124.1	IPR001853: DSBA oxidoreductase
YP_218127.1	IPR001584: Integrase, catalytic domain
YP_218128.1	DHBP synthase; functions during riboflavin biosynthesis
YP_218129.1	IPR007475: Protein of unknown function DUF526
YP_218130.1	Involved in glycogen synthesis. May be involved in glycogen priming
YP_218133.1	IPR001107: Band 7 protein
YP_218134.1	catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose
YP_218135.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_218136.1	IPR007899: CHAD; IPR008172: Adenylate cyclase
YP_218137.1	IPR003646: Bacterial SH3-like region
YP_218138.1	catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases
YP_218139.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_218140.1	catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin
YP_218141.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX
YP_218142.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_218143.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_218144.1	synthesizes RNA primers at the replication forks
YP_218145.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria
YP_218146.1	IPR005122: Uracil-DNA glycosylase superfamily
YP_218147.1	IPR007037: Siderophore-interacting protein
YP_218148.1	IPR005149: Transcriptional regulator PadR-like family
YP_218149.1	IPR003660: Histidine kinase, HAMP region; IPR004089: Bacterial chemotaxis sensory transducer; IPR004090: Methyl-accepting chemotaxis protein
YP_218150.1	senses cellular redox state or proton motive force; IPR000014: PAS domain; IPR001610: PAC motif; IPR003660: Histidine kinase, HAMP region;IPR004089: Bacterial chemotaxis sensory transducer;IPR004090: Methyl-accepting chemotaxis protein
YP_218152.2	catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate
YP_218153.1	IPR000205: NAD-binding site; IPR000759: Adrenodoxin reductase; IPR001100: Pyridine nucleotide-disulphide oxidoreductase, class I;IPR001155: NADH:flavin oxidoreductase/NADH oxidase;IPR001327: FAD-dependent pyridine nucleotide-disulphide oxidoreductase
YP_218154.1	IPR000051: SAM (and some other nucleotide) binding motif; IPR002052: N-6 Adenine-specific DNA methylase; IPR007848: Methyltransferase small
YP_218157.1	IPR000683: Oxidoreductase, N-terminal
YP_218158.1	IPR005496: Integral membrane protein TerC family
YP_218159.1	involved in the import of serine and threonine coupled with the import of sodium
YP_218160.1	IPR000252: DedA family
YP_218166.1	IPR007301: DoxD-like protein
YP_218167.1	IPR008523: Protein of unknown function DUF805
YP_218168.1	IPR000847: Bacterial regulatory protein LysR, HTH motif; IPR005119: LysR substrate binding domain
YP_218169.1	IPR003829: Pirin, N-terminal
YP_218172.1	IPR002091: Aromatic amino acid permease; IPR002422: Amino acid/polyamine transporter family II; IPR004694: Serine transporter
YP_218173.1	IPR004644: Iron-sulfur-dependent L-serine dehydratase single chain form; IPR005130: Serine dehydratase alpha chain; IPR005131: Serine dehydratase beta chain
YP_218174.1	IPR001150: Formate C-acetyltransferase glycine radical; IPR004184: Pyruvate formate-lyase, PFL; IPR005949: Formate acetyltransferase
YP_218175.1	catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism
YP_218176.1	involved in the import of threonine and serine in combination with the import of a proton
YP_218177.1	catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic
YP_218178.1	regulates the tdcABCDEFG operon which is involved in amino acid degradation
YP_218181.1	IPR004381: Conserved hypothetical protein 45
YP_218182.1	catalyzes the reduction of tartronate semialdehyde to glycerate
YP_218183.1	cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate
YP_218184.1	catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway
YP_218186.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_218187.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_218188.1	IPR001865: Ribosomal protein S2; IPR004703: PTS system Galactitol-specific IIC component
YP_218189.1	Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate
YP_218190.1	IPR001034: Bacterial regulatory protein, DeoR family; IPR001969: Eukaryotic/viral aspartic protease, active site
YP_218191.1	IPR000878: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; IPR008189: Protein of unknown function UPF0011
YP_218192.1	IPR007443: LppC  lipoprotein
YP_218193.2	IPR003509: Protein of unknown function UPF0102
YP_218194.1	Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein
YP_218195.1	IPR007055: Transport-associated domain
YP_218197.1	IPR002818: Protein of unknown function ThiJ/PfpI; IPR006286: Intracellular protease PfpI
YP_218199.1	IPR000305: Excinuclease ABC, C subunit, N-terminal
YP_218200.1	IPR000182: GCN5-related N-acetyltransferase
YP_218201.1	IPR003033: Sterol-binding
YP_218202.1	IPR001539: Peptidase U32
YP_218203.1	IPR001539: Peptidase U32
YP_218204.1	IPR002103: Bacterial luciferase
YP_218207.1	tryptophan transporter of high affinity
YP_218208.2	participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division
YP_218209.1	lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing
YP_218210.1	IPR000110: Ribosomal protein S1; IPR001247: 3' exoribonuclease; IPR003029: RNA binding S1;IPR004087: KH domain;IPR004088: KH domain, type 1
YP_218211.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_218212.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_218213.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_218214.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_218215.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_218216.2	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_218218.2	catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis
YP_218219.2	IPR004692: Preprotein translocase SecG subunit
YP_218220.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_218221.1	inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins
YP_218222.1	Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit
YP_218223.1	RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability
YP_218224.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_218225.1	penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains
YP_218226.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_218227.1	IPR000620: Protein of unknown function DUF6
YP_218228.1	involved in the peptidyltransferase reaction during translation
YP_218230.1	IPR000092: Polyprenyl synthetase
YP_218231.1	activator of maltose metabolism genes
YP_218232.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_218233.1	IPR002634: BolA-like protein
YP_218234.1	IPR002645: Sulfate transporter/antisigma-factor antagonist STAS
YP_218235.1	IPR008869: Toluene tolerance
YP_218236.1	IPR003399: Mce4/Rv3499c/MTV023.06c protein
YP_218237.1	IPR003453: Protein of unknown function DUF140
YP_218238.1	ATP-binding subunit of a  ABC toluene efflux transporter
YP_218239.1	YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers
YP_218240.1	IPR000644: CBS domain; IPR001347: Sugar isomerase (SIS); IPR004800: KpsF/GutQ family protein
YP_218241.1	forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis
YP_218243.1	LptA; periplasmic binding protein part of a  ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system
YP_218244.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter; IPR003593: AAA ATPase
YP_218245.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen
YP_218246.1	YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing
YP_218247.1	IPR002178: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; IPR006320: PTS IIA-like nitrogen-regulatory protein PtsN
YP_218248.1	IPR005337: Uncharacterised P-loop ATPase family UPF0042
YP_218249.1	IPR000032: Phosphocarrier HPr protein; IPR001020: HPr histidine phosphorylation site; IPR002114: HPr serine phosphorylation site
YP_218251.1	glycosyltransferase; polymerizes glycan strands in the peptidoglycan
YP_218252.1	IPR002818: Protein of unknown function ThiJ/PfpI
YP_218253.1	sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA
YP_218254.1	IPR005911: Conserved hypothetical protein 1212; IPR006638: Elongator protein 3/MiaB/NifB; IPR007197: Radical SAM
YP_218255.1	catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate
YP_218256.1	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate
YP_218258.1	IPR001248: Permease for cytosine/purines, uracil, thiamine, allantoin
YP_218259.1	Catalyzes the deamination of cytosine to uracil and ammonia
YP_218260.1	IPR004375: Conserved hypothetical protein 22
YP_218261.1	catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein
YP_218262.1	Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate
YP_218263.1	IPR004742: Sialic acid transporter; IPR005828: General substrate transporter; IPR007114: Major facilitator superfamily
YP_218264.1	catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid
YP_218265.1	Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization
YP_218266.1	IPR007481: Stringent starvation protein B
YP_218267.1	transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation
YP_218269.1	forms a direct contact with the tRNA during translation
YP_218270.2	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_218271.1	IPR005654: AFG1-like ATPase
YP_218273.1	IPR001254: Peptidase S1, chymotrypsin family; IPR001478: PDZ/DHR/GLGF domain; IPR001940: Peptidase S1C, HtrA/DegQ protease
YP_218274.1	IPR001254: Peptidase S1, chymotrypsin family; IPR001478: PDZ/DHR/GLGF domain; IPR001940: Peptidase S1C, HtrA/DegQ protease
YP_218276.1	IPR005661: Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit
YP_218277.1	catalyzes the formation of pyruvate from oxaloacetate
YP_218278.1	catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide
YP_218279.1	Involved in the tartrate degradation pathway
YP_218280.1	Involved in the tartrate degradation pathway
YP_218281.1	IPR001898: Sodium/sulphate symporter
YP_218282.1	IPR000524: Bacterial regulatory protein, GntR family
YP_218283.1	IPR000524: Bacterial regulatory protein, GntR family
YP_218284.1	oxidizes malate to oxaloacetate
YP_218285.1	regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes
YP_218289.1	with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate
YP_218290.1	with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate
YP_218291.1	membrane protein AaeX; the gene is a member of the aaeXAB operon
YP_218292.1	IPR000847: Bacterial regulatory protein LysR, HTH motif; IPR005119: LysR substrate binding domain
YP_218293.2	responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA
YP_218295.1	involved in the processing of the 5'end of 16S rRNA
YP_218296.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_218297.1	part of cell wall structural complex MreBCD; transmembrane component
YP_218298.1	in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall
YP_218299.2	functions in MreBCD complex in some organisms
YP_218300.1	regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules
YP_218301.1	IPR000566: Lipocalin-related protein and Bos/Can/Equ allergen; IPR001092: Basic helix-loop-helix dimerization domain bHLH; IPR002085: Zinc-containing alcohol dehydrogenase superfamily
YP_218302.1	in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ
YP_218303.1	in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme
YP_218304.1	composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_218305.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_218307.1	mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase
YP_218308.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_218309.1	IPR001269: Protein of unknown function UPF0034; IPR003009: FMN/related compound-binding core; IPR004652: TIM-barrel protein nifR3
YP_218310.1	Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription
YP_218311.1	IPR001091: Site-specific DNA-methyltransferase (cytosine-N4-specific); IPR002052: N-6 Adenine-specific DNA methylase; IPR002295: N6 adenine-specific DNA methyltransferase, D21 class;IPR002941: DNA methylase N-4/N-6
YP_218313.1	IPR001647: Bacterial regulatory protein TetR, HTH motif
YP_218315.1	IPR001036: Acriflavin resistance protein; IPR004764: Hydrophobe/amphiphile efflux-1 HAE1
YP_218322.1	IPR001451: Bacterial transferase hexapeptide repeat
YP_218324.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_218325.1	RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA
YP_218326.1	IPR000380: DNA topoisomerase I
YP_218327.1	IPR007456: Protein of unknown function DUF494
YP_218328.1	IPR003488: SMF protein
YP_218329.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_218330.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_218331.1	catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase
YP_218332.1	involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain
YP_218333.1	forms homopentamer; channel that opens in response to pressure or hypoosmotic shock
YP_218334.1	mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators
YP_218336.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_218337.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_218338.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_218339.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_218340.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_218341.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_218342.1	late assembly protein
YP_218343.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_218344.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_218345.1	binds 5S rRNA along with protein L5 and L25
YP_218346.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_218347.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_218348.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_218349.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_218350.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_218351.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_218352.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_218353.1	one of the stabilizing components for the large ribosomal subunit
YP_218354.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_218355.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_218357.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_218358.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_218359.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_218360.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_218361.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_218362.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_218363.1	IPR000045: Prepilin cysteine protease (C20), type IV
YP_218364.1	iron storage protein
YP_218365.1	IPR007419: BFD-like [2Fe-2S]-binding domain
YP_218366.2	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_218367.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_218368.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_218369.2	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_218370.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_218371.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_218372.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_218374.1	rotamase
YP_218375.1	IPR007236: SlyX
YP_218376.1	rotamase
YP_218378.1	involved in potassium efflux
YP_218379.1	required for KefB activity
YP_218380.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter; IPR003593: AAA ATPase
YP_218383.1	IPR000073: Alpha/beta hydrolase fold; IPR000379: Esterase/lipase/thioesterase; IPR000952: Protein of unknown function UPF0017
YP_218385.1	IPR006082: Phosphoribulokinase; IPR006083: Phosphoribulokinase/uridine kinase
YP_218386.1	IPR003718: OsmC-like protein
YP_218387.1	complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons
YP_218389.1	DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate
YP_218390.1	aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity
YP_218391.1	IPR003812: Filamentation induced by cAMP protein Fic
YP_218392.1	IPR002130: Peptidyl-prolyl cis-trans isomerase, cyclophilin type
YP_218393.1	IPR005829: Sugar transporter superfamily; IPR007114: Major facilitator superfamily
YP_218395.1	IPR000103: Pyridine nucleotide-disulphide oxidoreductase, class-II; IPR001100: Pyridine nucleotide-disulphide oxidoreductase, class I; IPR001327: FAD-dependent pyridine nucleotide-disulphide oxidoreductase;IPR005117: Nitrite/sulfite reductase ferredoxin-like half domain;IPR006066: Nitrite and sulfite reductase iron-sulfur/siroheme-binding site;IPR006067: Nitrite and sulphite reductase 4Fe-4S domain;IPR007419: BFD-like [2Fe-2S]-binding domain
YP_218396.1	involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations
YP_218397.1	member of the FNT family of formate and nitrite transporters
YP_218398.1	multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin
YP_218400.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_218401.1	catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate
YP_218402.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_218403.1	IPR002052: N-6 Adenine-specific DNA methylase; IPR002294: N6 adenine-specific DNA methyltransferase, D12 class
YP_218404.1	IPR001950: Translation initiation factor SUI1
YP_218405.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_218406.1	type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_218407.1	outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa
YP_218410.1	IPR007813: Fimbrial assembly
YP_218412.2	bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits
YP_218413.2	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_218415.1	IPR005833: Haloacid dehalogenase/epoxide hydrolase; IPR005834: Haloacid dehalogenase-like hydrolase; IPR006402: HAD-superfamily hydrolase, subfamily IA, variant 3
YP_218416.1	IPR002942: RNA-binding S4
YP_218417.2	becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers
YP_218419.1	PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP
YP_218420.1	membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR
YP_218421.1	part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation
YP_218422.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_218423.1	IPR003029: RNA binding S1; IPR006641: Ribonuclease RNase H fold containing
YP_218424.1	IPR007167: FeoA
YP_218425.1	cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake
YP_218427.1	IPR006842:  transposase, YhgA-like
YP_218428.1	Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis
YP_218429.1	involved in high-affinity gluconate transport
YP_218430.1	cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source
YP_218431.1	IPR003474: Gluconate transporter
YP_218432.1	amylomaltase; acts to release glucose from maltodextrins
YP_218433.1	IPR000811: Glycosyl transferase, family 35
YP_218434.1	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides
YP_218436.1	catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester
YP_218437.1	IPR001233: Protein of unknown function UPF0027
YP_218438.1	IPR003439: ABC transporter; IPR008858: TROVE
YP_218440.1	IPR002078: Sigma-54 factor interaction domain; IPR003593: AAA ATPase
YP_218441.1	represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism
YP_218442.1	protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity
YP_218443.1	belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine
YP_218444.1	in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane
YP_218447.1	forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone
YP_218448.1	IPR005828: General substrate transporter; IPR007114: Major facilitator superfamily
YP_218449.1	IPR002220: Dihydrodipicolinate synthetase
YP_218450.1	IPR005471: Bacterial regulatory proteins, IclR family; IPR005473: Bacterial transcription regulator, ICLR-like family
YP_218451.1	IPR000811: Glycosyl transferase, family 35
YP_218452.1	catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose
YP_218453.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_218454.1	catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen
YP_218455.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_218456.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_218458.1	IPR003474: Gluconate transporter
YP_218459.2	thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate
YP_218460.1	IPR000843: Bacterial regulatory protein LacI, HTH motif; IPR001761: Periplasmic binding protein/LacI transcriptional regulator
YP_218461.1	IPR003829: Pirin, N-terminal; IPR007113: Cupin domain
YP_218462.1	IPR000683: Oxidoreductase, N-terminal; IPR004104: Oxidoreductase, C-terminal
YP_218463.1	YhhY; regulated by the fur regulator; unknown function
YP_218464.1	IPR001034: Bacterial regulatory protein, DeoR family; IPR002139: Ribokinase; IPR002173: Carbohydrate kinase, PfkB
YP_218467.1	periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides
YP_218469.1	hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate
YP_218470.1	part of the UgpABCE glycerol-3-phosphate uptake system
YP_218471.1	with UgpABC is involved in uptake of glycerol-3-phosphate
YP_218472.1	with UgpEC is involved in the uptake of glycerol-3-phosphate
YP_218473.1	with UgpACE is involved in the uptake of glycerol-3-phosphate
YP_218474.1	similar to death -on-curing protein of phage P; IPR006440: Death-on-curing family protein
YP_218475.1	IPR003756: Protein of unknown function DUF172; IPR006442: Prevent-host-death family protein
YP_218476.1	with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_218477.1	Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_218478.1	Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_218479.1	LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter
YP_218480.1	IPR000182: GCN5-related N-acetyltransferase
YP_218481.1	IPR000182: GCN5-related N-acetyltransferase
YP_218483.1	IPR000709: Leu/Ile/Val-binding protein family; IPR001828: Extracellular ligand-binding receptor
YP_218484.1	binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters
YP_218485.1	ABC transporter membrane protein
YP_218486.1	ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions
YP_218487.1	signal recognition protein receptor; functions in the targeting and insertion of membrane proteins
YP_218488.1	catalyzes the methylation of 16S rRNA at position G966
YP_218492.1	P-type ATPase involved in the export of lead, cadmium, zinc and mercury
YP_218493.1	IPR003122: Ligand binding Tar; IPR003660: Histidine kinase, HAMP region; IPR004089: Bacterial chemotaxis sensory transducer;IPR004090: Methyl-accepting chemotaxis protein;IPR004091: Aspartate chemoreceptor protein
YP_218494.2	TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs
YP_218495.1	IPR003744: Protein of unknown function DUF165
YP_218497.2	IPR007114: Major facilitator superfamily
YP_218498.1	IPR002549: Protein of unknown function UPF0118
YP_218499.1	IPR008278: 4'-phosphopantetheinyl transferase
YP_218500.1	Inhibits transcription at high concentrations of nickel
YP_218501.1	IPR000412: ABC transporter family 2
YP_218502.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter; IPR003593: AAA ATPase
YP_218503.1	IPR003997: Gram-negative bacterial RTX secretion protein D; IPR006143: Secretion protein HlyD
YP_218504.1	IPR000205: NAD-binding site; IPR001100: Pyridine nucleotide-disulphide oxidoreductase, class I; IPR001327: FAD-dependent pyridine nucleotide-disulphide oxidoreductase;IPR004792: HI0933-like protein
YP_218505.1	IPR001092: Basic helix-loop-helix dimerization domain bHLH; IPR001204: Phosphate transporter
YP_218506.1	ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress
YP_218507.1	IPR006016: Usp domain
YP_218508.1	member of the POT family of peptide transporters; probable proton-dependent peptide transporter function
YP_218509.1	predicted SAM-dependent methyltransferase
YP_218510.1	IPR001567: Peptidase M3; IPR006025: Neutral zinc metallopeptidases, zinc-binding site
YP_218511.1	IPR000326: PA-phosphatase related phosphoesterase; IPR001011: Bacterial acid phosphatase, class A
YP_218512.1	IPR002052: N-6 Adenine-specific DNA methylase; IPR007473: Protein of unknown function DUF519
YP_218513.1	catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense
YP_218514.1	IPR007114: Major facilitator superfamily
YP_218517.1	IPR000281: Helix-turn-helix protein RpiR; IPR001347: Sugar isomerase (SIS)
YP_218518.1	IPR002139: Ribokinase; IPR002173: Carbohydrate kinase, PfkB
YP_218519.1	IPR004550: L-asparaginase, type II; IPR006034: Asparaginase/glutaminase
YP_218520.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB
YP_218521.1	IPR002173: Carbohydrate kinase, PfkB
YP_218522.1	IPR001347: Sugar isomerase (SIS)
YP_218523.1	IPR000524: Bacterial regulatory protein, GntR family
YP_218524.1	cytoplasmic; catalyzes the hydrolysis of trehalose to glucose
YP_218527.1	IPR000792: Bacterial regulatory protein, LuxR family
YP_218528.1	IPR002559: Transposase, IS4
YP_218529.1	IPR004664: Ribonuclease BN; IPR005274: Conserved hypothetical protein 766
YP_218530.1	IPR000911: Ribosomal protein L11; IPR004736: Citrate-proton symport; IPR005828: General substrate transporter;IPR005829: Sugar transporter superfamily;IPR007114: Major facilitator superfamily
YP_218531.1	IPR007844: AsmA
YP_218532.1	in Escherichia coli this protein is involved in flagellar function
YP_218533.1	IPR002173: Carbohydrate kinase, PfkB
YP_218534.1	IPR001092: Basic helix-loop-helix dimerization domain bHLH; IPR001431: Peptidase M16, insulinase-like; IPR007863: Peptidase M16 inactive
YP_218535.1	involved in the transport of C4-dicarboxylates across the membrane
YP_218536.1	HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a  phosphodiesterase protein from E. coli
YP_218537.1	cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA
YP_218543.1	IPR001220: Legume lectin, beta domain; IPR002422: Amino acid/polyamine transporter family II; IPR002453: Beta tubulin
YP_218544.1	Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides
YP_218545.1	DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF
YP_218546.1	IPR000515: Binding-protein-dependent transport systems inner membrane component
YP_218547.1	transports peptides consisting of two or three amino acids
YP_218548.1	IPR000914: Bacterial extracellular solute-binding protein, family 5
YP_218549.1	IPR006043: Xanthine/uracil/vitamin C permease family
YP_218553.1	IPR000843: Bacterial regulatory protein LacI, HTH motif; IPR001761: Periplasmic binding protein/LacI transcriptional regulator
YP_218554.2	catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide
YP_218555.1	IPR000259: Fimbrial protein
YP_218556.1	IPR000259: Fimbrial protein
YP_218557.1	IPR001829: Bacterial pili assembly chaperone
YP_218558.1	IPR000259: Fimbrial protein
YP_218561.1	constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine
YP_218562.1	IPR000182: GCN5-related N-acetyltransferase
YP_218563.1	IPR006655: Prokaryotic molybdopterin oxidoreductase; IPR006656: Molybdopterin oxidoreductase; IPR006657: Molydopterin dinucleotide binding domain;IPR006658: Molybdopterin guanine dinucleotide-containing S/N-oxide reductase
YP_218564.1	IPR001035: MotY protein; IPR006664: Bacterial outer membrane protein; IPR006665: OmpA/MotB domain;IPR006690: OmpA-like domain
YP_218565.1	Involved in the metabolism of aromatic amino acids
YP_218568.1	IPR002059: Cold-shock DNA-binding domain
YP_218571.1	IPR001584: Integrase, catalytic domain
YP_218574.1	IPR000182: GCN5-related N-acetyltransferase
YP_218576.1	IPR002559: Transposase, IS4
YP_218577.1	glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_218578.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_218580.1	IPR002656: Acyltransferase 3 family
YP_218581.1	IPR008024: YiaAB two helix
YP_218582.1	IPR000577: Carbohydrate kinase, FGGY; IPR006000: Xylulokinase
YP_218583.1	catalyzes the interconversion of D-xylose to D-xylulose
YP_218584.1	IPR000005: Helix-turn-helix, AraC type; IPR001761: Periplasmic binding protein/LacI transcriptional regulator
YP_218585.1	IPR002901: Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase
YP_218588.1	catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate
YP_218589.1	L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate
YP_218590.1	IPR000005: Helix-turn-helix, AraC type; IPR003313: Arac protein, arabinose-binding/dimerisation
YP_218591.1	IPR002086: Aldehyde dehydrogenase
YP_218592.1	IPR000600: ROK family
YP_218593.1	IPR000795: Elongation factor, GTP-binding; IPR004161: Elongation factor Tu, domain 2; IPR004535: Translation elongation factor, selenocysteine-specific
YP_218594.1	catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis
YP_218595.1	IPR004045: Glutathione S-transferase, N-terminal; IPR004046: Glutathione S-transferase, C-terminal
YP_218596.1	IPR002178: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; IPR003352: Phosphotransferase system, EIIC; IPR003501: Phosphotransferase system, lactose/cellobiose-specific IIB subunit;IPR004718: PTS system mannitol-specific enzyme IIC
YP_218597.1	IPR000669: Mannitol dehydrogenase
YP_218598.1	Acts as a repressor of the mtlAD operon
YP_218602.1	IPR005594: YadA-like, C-terminal; IPR008635: Haemagluttinin motif; IPR008640: Hep_Hag
YP_218603.1	IPR003804: L-lactate permease
YP_218604.1	represses the lctPRD operon
YP_218605.1	flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration
YP_218606.1	member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates
YP_218607.1	IPR000843: Bacterial regulatory protein LacI, HTH motif; IPR001761: Periplasmic binding protein/LacI transcriptional regulator
YP_218608.1	IPR001354: Mandelate racemase/muconate lactonizing enzyme
YP_218609.1	catalyzes the O-acetylation of serine
YP_218610.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_218611.1	molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA
YP_218612.1	IPR002109: Glutaredoxin
YP_218613.1	IPR001763: Rhodanese-like
YP_218614.1	catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YP_218615.1	IPR002886: Peptidase  M23/M37
YP_218617.1	IPR001173: Glycosyl transferase, family 2
YP_218618.1	converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism
YP_218619.1	catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine
YP_218620.1	catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose
YP_218621.1	catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core
YP_218622.1	IPR000669: Mannitol dehydrogenase
YP_218627.1	IPR000531: TonB-dependent receptor protein
YP_218628.1	IPR002495: Glycosyl transferase, family 8
YP_218632.1	IPR001064: Beta and gamma crystallin
YP_218634.1	catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A
YP_218635.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_218636.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_218637.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_218638.1	required for 70S ribosome assembly
YP_218639.1	Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase
YP_218640.2	catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine
YP_218641.1	catalyzes the formation of dUMP from dUTP
YP_218642.1	FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly
YP_218643.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_218644.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_218646.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_218649.2	this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+
YP_218651.1	Essential for recycling GMP and indirectly, cGMP
YP_218652.1	promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_218653.1	bifunctional
YP_218654.1	specifically modifies tRNA at position G18
YP_218655.1	catalyzes branch migration in Holliday junction intermediates
YP_218657.1	IPR004445: Sodium/glutamate symporter
YP_218658.1	IPR006042: Xanthine/uracil permease family
YP_218660.1	catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides
YP_218661.2	may be involved in the transport of galactosides-pentoses-hexuronides
YP_218662.1	IPR002197: Helix-turn-helix, Fis-type
YP_218664.1	IPR000792: Bacterial regulatory protein, LuxR family
YP_218665.1	IPR000694: Proline-rich region; IPR004899: Pertactin domain; IPR005546: Autotransporter beta-domain;IPR006315: Outer membrane autotransporter barrel
YP_218671.1	IPR000695: H+ transporting ATPase, proton pump; IPR001757: ATPase, E1-E2 type
YP_218672.1	IPR003416: MgtC/SapB transporter
YP_218676.1	IPR004704: PTS system mannose/fructose/sorbose family IID component
YP_218678.1	IPR004720: PTS system sorbose subfamily IIB component
YP_218680.1	IPR002078: Sigma-54 factor interaction domain; IPR002464: ATP-dependent helicase, DEAH-box
YP_218682.1	IPR001360: Glycoside hydrolase, family 1
YP_218687.1	IPR000032: Phosphocarrier HPr protein; IPR001020: HPr histidine phosphorylation site
YP_218688.1	class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis
YP_218689.1	IPR000345: Cytochrome c  heme-binding site
YP_218692.1	IPR002178: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
YP_218693.1	IPR000524: Bacterial regulatory protein, GntR family
YP_218695.1	cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate
YP_218696.1	Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph
YP_218697.1	response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter
YP_218698.1	IPR003006: Immunoglobulin/major histocompatibility complex
YP_218699.1	IPR007114: Major facilitator superfamily
YP_218700.1	IPR002139: Ribokinase
YP_218701.1	IPR001034: Bacterial regulatory protein, DeoR family
YP_218702.1	with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit
YP_218703.1	catalyzes the formation of 2-acetolactate from pyruvate
YP_218707.1	multidrug efflux protein involved in adaptation to low energy shock
YP_218709.1	regulates the synthesis and expression of the dsdXA operon and dadA gene
YP_218710.1	member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function
YP_218711.1	catalyzes the formation of pyruvate from serine
YP_218718.1	16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent
YP_218719.1	with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress
YP_218722.1	IPR004799: Periplasmic protein thiol:disulfide oxidoreductase DsbE; IPR006662: Thioredoxin type domain; IPR006663: Thioredoxin domain 2
YP_218723.1	IPR003567: Cytochrome c-type biogenesis protein; IPR003568: Cytochrome c-type biogenesis protein CcmF
YP_218724.1	IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter; IPR004329: CcmE/CycJ protein
YP_218725.1	IPR000345: Cytochrome c  heme-binding site
YP_218726.1	TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor
YP_218727.1	IPR006655: Prokaryotic molybdopterin oxidoreductase
YP_218728.1	IPR000345: Cytochrome c  heme-binding site; IPR005126: NapC/NirT cytochrome c, N-terminal
YP_218729.1	response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes
YP_218730.1	Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide
YP_218731.1	IPR000849: GlpT transporter; IPR004744: D-galactonate transporter; IPR005828: General substrate transporter;IPR007114: Major facilitator superfamily
YP_218732.1	in bifunctional: 2-oxo-3-deoxygalactonate 6-phosphate aldolase and galactonate dehydratase; IPR001354: Mandelate racemase/muconate lactonizing enzyme
YP_218733.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism
YP_218735.1	IPR000524: Bacterial regulatory protein, GntR family
YP_218736.1	YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins
YP_218737.1	IPR007114: Major facilitator superfamily
YP_218738.1	IPR001354: Mandelate racemase/muconate lactonizing enzyme
YP_218740.1	negatively supercoils closed circular double-stranded DNA
YP_218741.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_218742.1	binds the polymerase to DNA and acts as a sliding clamp
YP_218743.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_218744.1	in Escherichia coli transcription of this gene is enhanced by polyamines
YP_218745.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_218746.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_218747.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_218748.1	Confers resistance to chloramphenicol
YP_218750.2	IPR005025: NADPH-dependent FMN reductase
YP_218752.1	IPR002040: Tachykinin/Neurokinin; IPR006043: Xanthine/uracil/vitamin C permease family
YP_218753.1	YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily
YP_218754.1	regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon
YP_218755.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_218756.1	Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions
YP_218757.1	part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions
YP_218759.1	catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_218761.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_218762.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_218763.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_218764.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_218765.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_218766.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_218767.1	Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_218768.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_218769.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_218770.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_218771.2	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation
YP_218773.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_218774.1	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_218775.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_218776.1	transcriptional repressor of asnA which codes for aspartate-ammonia ligase
YP_218777.1	catalyzes the formation of asparagine from aspartate and ammonia
YP_218778.1	contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA
YP_218779.2	interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase
YP_218780.1	Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH
YP_218781.1	cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source
YP_218782.1	with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain
YP_218783.1	functions to transport ribose at high affinity; forms a complex with RbsA2C2B
YP_218784.1	periplasmic substrate-binding component of the ATP-dependent ribose transport system
YP_218785.1	catalyzes the formation of D-ribose 5-phosphate from ribose
YP_218786.1	DNA-binding transcriptional repressor of ribose metabolism
YP_218787.1	IPR001411: Tetracycline resistance protein TetB; IPR007114: Major facilitator superfamily
YP_218788.1	IPR000524: Bacterial regulatory protein, GntR family
YP_218791.1	Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon
YP_218793.1	among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function
YP_218795.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_218796.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_218797.1	threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway
YP_218800.1	participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate
YP_218801.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_218802.1	IPR000297: PpiC-type peptidyl-prolyl cis-trans isomerase
YP_218805.1	single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication
YP_218806.1	catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation
YP_218807.1	enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation
YP_218808.1	IPR006662: Thioredoxin type domain; IPR006663: Thioredoxin domain 2
YP_218809.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_218811.1	Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein
YP_218813.2	catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid
YP_218817.1	catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis
YP_218819.1	catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis
YP_218820.1	enterobacterial common antigen polymerase
YP_218822.1	uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function
YP_218823.1	a late step of protoheme IX synthesis; IPR001440: TPR repeat; IPR001993: Mitochondrial substrate carrier; IPR005254: Protoheme IX biosynthesis protein
YP_218825.1	catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis
YP_218826.1	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_218827.1	catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP
YP_218828.1	defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly
YP_218833.2	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_218835.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_218836.1	YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function
YP_218837.1	unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.
YP_218838.1	responsible for the influx of magnesium ions
YP_218842.2	IPR003736: Phenylacetic acid degradation-related protein; IPR006683: Thioesterase superfamily
YP_218843.1	catalyzes the hydrolysis of phosphatidylcholine
YP_218844.1	functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway
YP_218845.1	IPR001123: Lysine exporter protein (LYSE/YGGA)
YP_218846.1	IPR001123: Lysine exporter protein (LYSE/YGGA)
YP_218847.1	lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates
YP_218848.1	purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium
YP_218850.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_218851.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_218853.1	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway
YP_218854.1	YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner
YP_218855.1	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_218857.1	an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions
YP_218858.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_218859.1	mediates the export of protein precursors bearing twin-arginine signal peptides
YP_218860.1	with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane
YP_218861.1	magnesium dependent; not involved in the Sec-independent protein export system
YP_218863.1	catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol
YP_218864.1	NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin
YP_218866.1	FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids
YP_218867.2	includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids
YP_218868.1	catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters
YP_218869.1	IPR001498: Protein of unknown function UPF0029
YP_218870.1	catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX
YP_218873.1	in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway
YP_218874.1	in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis
YP_218876.1	catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages
YP_218877.1	IPR006662: Thioredoxin type domain; IPR006663: Thioredoxin domain 2
YP_218878.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_218880.1	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential
YP_218883.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_218884.2	response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54
YP_218885.1	sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation
YP_218886.1	forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme
YP_218887.1	IPR000640: Elongation factor G, C-terminal; IPR000795: Elongation factor, GTP-binding; IPR004161: Elongation factor Tu, domain 2;IPR005225: Small GTP-binding protein domain;IPR006298: GTP-binding protein TypA
YP_218888.1	IPR000150: Cof protein
YP_218890.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_218894.2	porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown
YP_218895.1	IPR001927: Sodium:galactoside symporter
YP_218896.1	IPR001927: Sodium:galactoside symporter
YP_218898.1	IPR008183: Aldose 1-epimerase
YP_218900.1	IPR000205: NAD-binding site; IPR002204: 3-hydroxyisobutyrate dehydrogenase
YP_218901.1	IPR002139: Ribokinase; IPR002173: Carbohydrate kinase, PfkB
YP_218902.1	IPR001034: Bacterial regulatory protein, DeoR family
YP_218903.1	IPR005833: Haloacid dehalogenase/epoxide hydrolase
YP_218904.1	RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease
YP_218905.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_218906.1	IPR000182: GCN5-related N-acetyltransferase
YP_218907.1	IPR000379: Esterase/lipase/thioesterase; IPR002168: Lipolytic enzyme
YP_218911.1	required for the formation of active formate dehydrogenase
YP_218912.1	cytochrome b556(FDO) component; heme containing
YP_218913.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_218914.1	involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth
YP_218918.1	IPR004471: AzlC protein
YP_218919.1	IPR007113: Cupin domain
YP_218921.1	IPR001670: Iron-containing alcohol dehydrogenase
YP_218923.1	catalyzes the formation of L-rhamnulose from L-rhamnose
YP_218924.1	catalyzes the ATP-dependent phosphorylation of rhamnulose
YP_218925.1	activates the expression of the rhaBAD operon and rhaT gene
YP_218926.1	activates the expression of rhaRS in response to L-rhamnose
YP_218927.1	transports L-rhamnose and L-lyxose into the cell
YP_218933.1	SodA; manganese binding; only present under aerobic conditions; destroys free radicals
YP_218934.2	IPR005163: 3-alpha domain; IPR005302: MOSC domain
YP_218936.1	part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors
YP_218937.1	response regulator in two-component regulatory system with CpxA; part of the envelope stress response system
YP_218938.1	repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates
YP_218939.1	member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers
YP_218940.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_218941.1	IPR000957: Prokaryotic sulfate-/thiosulfate-binding protein
YP_218943.1	IPR001927: Sodium:galactoside symporter
YP_218944.1	phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least
YP_218946.1	IPR000524: Bacterial regulatory protein, GntR family
YP_218948.1	IPR007113: Cupin domain
YP_218950.1	IPR007324:  sugar-binding domain
YP_218951.1	IPR001851: Bacterial inner-membrane translocator
YP_218952.1	IPR001851: Bacterial inner-membrane translocator
YP_218954.1	IPR001064: Beta and gamma crystallin
YP_218956.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_218957.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_218960.1	IPR000531: TonB-dependent receptor protein
YP_218961.2	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_218962.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_218963.1	IPR000425: MIP family
YP_218965.1	regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity
YP_218966.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate
YP_218967.1	heat shock protein involved in degradation of misfolded proteins
YP_218968.1	heat shock protein involved in degradation of misfolded proteins
YP_218970.2	negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins
YP_218971.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_218972.2	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_218977.1	when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis
YP_218978.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_218979.1	multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_218980.1	IPR006685: Mechanosensitive (MS) ion channel; IPR006686: Mechanosensitive (MS) ion channel subdomain; IPR008910: Conserved TM helix
YP_218984.1	MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor
YP_218985.1	IPR000763: Bacterial haem catalase/peroxidase; IPR002016: Haem peroxidase; IPR002207: Plant ascorbate peroxidase
YP_218987.1	forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone
YP_218988.1	similar to transaldolase from Escherichia coli; many organisms have multiple copies
YP_218989.1	IPR000032: Phosphocarrier HPr protein; IPR000121: PEP-utilizing enzyme; IPR001020: HPr histidine phosphorylation site;IPR002178: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;IPR008279: PEP-utilising enzyme, mobile region
YP_218990.1	FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site
YP_218991.1	FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS
YP_218992.1	IPR001989: Radical-activating enzyme
YP_218993.1	FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog
YP_218994.1	IPR000005: Helix-turn-helix, AraC type
YP_218996.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_218997.1	catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis
YP_218998.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_218999.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_219000.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_219001.1	Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA
YP_219002.1	catalyzes the conversion of NADPH to NADH
YP_219003.1	negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis
YP_219005.1	catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs
YP_219006.2	involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space
YP_219007.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_219012.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_219013.1	catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon
YP_219014.1	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis
YP_219017.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_219018.1	forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_219019.1	Modulates Rho-dependent transcription termination
YP_219020.1	binds directly to 23S ribosomal RNA
YP_219021.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_219022.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_219023.2	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_219024.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_219025.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_219028.1	in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center
YP_219029.2	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_219030.1	catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate
YP_219031.1	catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate
YP_219032.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_219033.1	binds specifically to the major sigma factor sigma 70; active in stationary phase
YP_219034.1	can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates
YP_219035.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_219036.1	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures
YP_219038.1	histone-like DNA-binding protein
YP_219041.1	IPR004358: Bacterial sensor protein, C-terminal; IPR005467: Histidine kinase
YP_219042.1	DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein
YP_219043.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_219048.1	catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis
YP_219049.1	Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle
YP_219050.1	Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates
YP_219051.1	catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol
YP_219053.1	regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase
YP_219054.2	one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity
YP_219056.1	alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family
YP_219059.1	catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA
YP_219067.1	IPR000531: TonB-dependent receptor protein
YP_219071.1	IPR001173: Glycosyl transferase, family 2
YP_219077.1	similar to orf4 in Pectobacterium carotovorum subsp. carotovorum
YP_219079.1	IPR007067: Phage tail sheath protein
YP_219086.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive
YP_219087.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_219093.1	with MalKFE is involved in the transport of maltose into the cell
YP_219094.1	with MalKGE is involved in maltose transport into the cell
YP_219095.2	functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis
YP_219096.1	with malEFG is involved in import of maltose/maltodextrin
YP_219097.1	porin involved in the transport of maltose and maltodextrins
YP_219099.1	catalyzes the formation of 4-hydroxybenzoate from chorismate
YP_219100.1	catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway
YP_219101.1	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_219102.1	IPR000829: Prokaryotic diacylglycerol kinase
YP_219103.1	Represses a number of genes involved in the response to DNA damage
YP_219106.1	unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential
YP_219107.1	Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB
YP_219109.1	IPR001269: Protein of unknown function UPF0034
YP_219110.1	coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia
YP_219111.1	IPR002364: Quinone oxidoreductase/zeta-crystallin
YP_219112.1	unwinds double stranded DNA
YP_219113.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_219114.2	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_219115.1	Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity
YP_219116.1	IPR001602: Protein of unknown function UPF0047
YP_219120.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_219121.1	binds to single stranded DNA and PriA helcase facilitate replication restart
YP_219126.1	IPR003997: Gram-negative bacterial RTX secretion protein D
YP_219127.1	IPR000150: Cof protein; IPR000566: Lipocalin-related protein and Bos/Can/Equ allergen; IPR001220: Legume lectin, beta domain;IPR002126: Cadherin
YP_219128.1	IPR000508: Signal peptidase; IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter
YP_219130.1	IPR001633: EAL domain
YP_219131.1	regulates genes involved in response to oxidative stress
YP_219132.1	IPR000551: Bacterial regulatory protein, MerR family
YP_219133.1	IPR004045: Glutathione S-transferase, N-terminal; IPR004046: Glutathione S-transferase, C-terminal
YP_219136.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_219137.1	IPR005538: LrgA family
YP_219139.1	member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake
YP_219141.1	Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA
YP_219143.1	catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552
YP_219144.1	part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia
YP_219145.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_219147.1	IPR000515: Binding-protein-dependent transport systems inner membrane component; IPR002541: Cytochrome c assembly protein; IPR003567: Cytochrome c-type biogenesis protein;IPR003568: Cytochrome c-type biogenesis protein CcmF;IPR003570: Cytochrome c-type biogenesis protein NrfE;IPR005616: Cytochrome C biogenesis protein
YP_219148.1	IPR001440: TPR repeat
YP_219150.1	carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system
YP_219153.1	PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role
YP_219154.1	IPR004360: Glyoxalase/Bleomycin resistance protein/dioxygenase domain
YP_219156.1	IPR005829: Sugar transporter superfamily; IPR007114: Major facilitator superfamily
YP_219157.1	IPR003660: Histidine kinase, HAMP region; IPR004358: Bacterial sensor protein, C-terminal; IPR005467: Histidine kinase
YP_219158.1	response regulator in two-component regulatory system with BasS
YP_219159.1	with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division
YP_219160.1	IPR002293: Amino acid/polyamine transporter family I
YP_219161.1	IPR000005: Helix-turn-helix, AraC type
YP_219162.1	catabolic; inducible by acid; IPR000310: Orn/Lys/Arg decarboxylase, major region; IPR005308: Orn/Lys/Arg decarboxylase, N-terminal domain; IPR008286: Orn/Lys/Arg decarboxylase, C-terminal
YP_219163.1	IPR000005: Helix-turn-helix, AraC type
YP_219164.1	IPR001088: Glycoside hydrolase, family 4
YP_219166.1	IPR000362: Fumarate lyase; IPR004646: Fe-S type hydro-lyases tartrate/fumarate alpha region; IPR004647: Fe-S type hydro-lyases tartrate/fumarate beta region
YP_219167.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters
YP_219168.1	response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration
YP_219169.1	C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration
YP_219170.1	IPR006655: Prokaryotic molybdopterin oxidoreductase
YP_219171.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_219177.1	IPR000792: Bacterial regulatory protein, LuxR family
YP_219178.1	IPR000005: Helix-turn-helix, AraC type
YP_219184.1	IPR000326: PA-phosphatase related phosphoesterase; IPR001011: Bacterial acid phosphatase, class A; IPR002048: Calcium-binding EF-hand
YP_219188.1	two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm
YP_219189.1	copper binding protein required for copper tolerance; involved in resistance toward heavy metals
YP_219190.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB
YP_219191.1	catalyzes the formation of fumarate from aspartate
YP_219193.1	F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein
YP_219194.1	uncharacterized member of the APC superfamily of amino acid transporters; unknown function
YP_219195.2	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_219196.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_219200.2	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_219203.1	IPR000792: Bacterial regulatory protein, LuxR family
YP_219204.1	member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations
YP_219205.1	lipocalin; globomycin-sensitive outer membrane lipoprotein
YP_219206.1	in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane
YP_219207.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_219208.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_219209.2	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_219210.1	lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_219211.1	IPR002293: Amino acid/polyamine transporter family I; IPR004841: Amino acid permease-associated region
YP_219213.1	IPR006686: Mechanosensitive (MS) ion channel subdomain
YP_219214.1	catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine
YP_219215.2	EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity
YP_219216.1	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_219217.1	IPR001311: Solute-binding protein/glutamate receptor; IPR001638: Bacterial extracellular solute-binding protein, family 3
YP_219218.1	IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
YP_219219.1	IPR000631: Protein of unknown function UPF0031; IPR000875: Cecropin
YP_219220.1	possibly involved in cell wall synthesis
YP_219222.1	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YP_219223.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_219224.1	Stimulates the elongation of poly(A) tails
YP_219225.1	involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein
YP_219226.1	with HflC inhibits proteolysis of lambda cII protein by FtsH
YP_219227.1	with HflK inhibits proteolysis of lambda cII protein by FtsH
YP_219229.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_219230.2	negatively regulates the transcription of genes upregulated by nitrosative stress
YP_219231.1	3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs
YP_219232.1	Specifically methylates the ribose of guanosine 2251 in 23S rRNA
YP_219234.1	IPR001622: K+ channel, pore region
YP_219238.2	catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA
YP_219240.1	in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility
YP_219241.1	YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo
YP_219242.1	negative regulator of ulaG and ulaABCDEF
YP_219244.2	membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr
YP_219245.1	involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_219246.1	involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_219247.2	catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization
YP_219248.1	UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway
YP_219249.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_219252.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_219253.1	binds single-stranded DNA at the primosome assembly site
YP_219254.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_219255.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_219258.2	FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YP_219259.1	involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine
YP_219262.1	Involved in anaerobic NO protection and iron metabolism
YP_219264.1	IPR002577: Protein of unknown function DUF24
YP_219265.1	periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate
YP_219266.1	catalyzes the formation of AMP from adenosine-3',5'-bisphosphate
YP_219269.1	IPR000644: CBS domain
YP_219270.1	this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress
YP_219271.1	IPR000566: Lipocalin-related protein and Bos/Can/Equ allergen
YP_219272.1	IPR000566: Lipocalin-related protein and Bos/Can/Equ allergen
YP_219274.1	IPR007114: Major facilitator superfamily
YP_219275.1	catalyzes the hydrolysis of pyrophosphate to phosphate
YP_219276.1	catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate
YP_219277.1	IPR000713: Cytoplasmic peptidoglycan synthetases, N-terminal; IPR004101: Cytoplasmic peptidoglycan synthetases, C-terminal; IPR005757: UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso- diaminopimelate ligase
YP_219279.2	protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD
YP_219287.1	Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides
YP_219290.1	IPR002178: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
YP_219291.1	Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor
YP_219293.1	activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions
YP_219294.1	Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates
YP_219297.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_219298.1	regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon
YP_219299.1	P-type ATPase involved in magnesium influx
YP_219300.1	IPR006056: YjgF-like protein
YP_219301.1	involved in the allosteric regulation of aspartate carbamoyltransferase
YP_219302.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_219304.1	IPR001669: Arginine repressor
YP_219306.1	catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway
YP_219307.1	reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP
YP_219308.1	catalyzes the degradation of arginine to citruline and ammonia
YP_219311.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.
YP_219318.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_219319.1	binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_219320.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_219322.1	IPR005495: Predicted permease YjgP/YjgQ family
YP_219324.1	IPR000843: Bacterial regulatory protein LacI, HTH motif; IPR001761: Periplasmic binding protein/LacI transcriptional regulator
YP_219326.1	Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate
YP_219327.1	NAD-binding
YP_219329.1	IPR000345: Cytochrome c  heme-binding site; IPR002328: Zinc-containing alcohol dehydrogenase; IPR006140: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
YP_219339.1	IPR001687: ATP/GTP-binding site motif A (P-loop)
YP_219342.2	IPR002876: Protein of unknown function DUF28
YP_219343.1	IPR000051: SAM (and some other nucleotide) binding motif; IPR001601: Generic methyltransferase
YP_219347.1	IPR005180: Protein of unknown function DUF302
YP_219348.1	IPR008262: Lipase, active site
YP_219349.1	regulates the expression of uxuBA
YP_219350.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_219352.1	IPR001920: Asp/Glu racemase; IPR004380: Aspartate racemase
YP_219353.1	IPR000847: Bacterial regulatory protein LysR, HTH motif
YP_219354.1	IPR003764: N-acetylglucosamine-6-phosphate deacetylase; IPR005847: Dihydroorotase region
YP_219359.1	IPR000634: Serine/threonine dehydratase, pyridoxal-phosphate-binding site; IPR005829: Sugar transporter superfamily; IPR007114: Major facilitator superfamily
YP_219366.1	involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response
YP_219367.1	IPR001123: Lysine exporter protein (LYSE/YGGA)
YP_219368.1	IPR000005: Helix-turn-helix, AraC type; IPR007113: Cupin domain
YP_219371.1	IPR003706: Carbon starvation protein CstA
YP_219372.1	IPR003660: Histidine kinase, HAMP region; IPR004089: Bacterial chemotaxis sensory transducer; IPR004090: Methyl-accepting chemotaxis protein;IPR004091: Aspartate chemoreceptor protein
YP_219375.1	IPR004720: PTS system sorbose subfamily IIB component
YP_219380.1	catalyzes the transfer of phosphoglycerol to the glucan backbone
YP_219382.1	acts to load the DnaB helicase onto the initiation site during DNA replication
YP_219383.1	This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'
YP_219387.2	regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin
YP_219390.1	IPR000160: GGDEF
YP_219392.1	16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit
YP_219393.2	alanine acetyltransferase that specifically acetylates ribosomal protein S18
YP_219394.1	manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily
YP_219395.1	stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein
YP_219396.1	IPR007055: Transport-associated domain
YP_219399.1	IPR001130: TatD-related deoxyribonuclease
YP_219400.1	IPR000345: Cytochrome c  heme-binding site; IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain; IPR001989: Radical-activating enzyme
YP_219402.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_219403.2	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
YP_219404.1	catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose
YP_219405.1	catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate
YP_219407.1	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins
YP_219410.1	catalyzes the formation of serine from O-phosphoserine
YP_219411.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_219412.1	catalyzes the formation of NAD(+) from nicotinamide ribonucleotide
YP_219413.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_219414.2	catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan
YP_219415.1	When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription
YP_219416.1	pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog
YP_219417.1	catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate
YP_219418.1	IPR000005: Helix-turn-helix, AraC type
YP_219420.1	response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation
YP_219421.1	part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation
YP_219422.1	IPR000531: TonB-dependent receptor protein
YP_219425.1	IPR000015: Fimbrial biogenesis outer membrane usher protein; IPR001064: Beta and gamma crystallin
YP_219426.1	IPR001829: Bacterial pili assembly chaperone
YP_219430.1	IPR001789: Response regulator receiver; IPR001867: Transcriptional regulatory protein, C terminal
YP_219432.1	member of the SPOUT superfamily of methyltransferases