-- dump date   	20140620_042117
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
657323000001	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
657323000002	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
657323000003	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
657323000004	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323000005	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657323000006	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
657323000007	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
657323000008	active site
657323000009	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
657323000010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323000011	active site
657323000012	phosphorylation site [posttranslational modification]
657323000013	intermolecular recognition site; other site
657323000014	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
657323000015	DNA binding residues [nucleotide binding]
657323000016	dimerization interface [polypeptide binding]; other site
657323000017	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323000018	Histidine kinase; Region: HisKA_3; pfam07730
657323000019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323000020	ATP binding site [chemical binding]; other site
657323000021	Mg2+ binding site [ion binding]; other site
657323000022	G-X-G motif; other site
657323000023	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
657323000024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000025	Walker A/P-loop; other site
657323000026	ATP binding site [chemical binding]; other site
657323000027	Q-loop/lid; other site
657323000028	ABC transporter signature motif; other site
657323000029	Walker B; other site
657323000030	D-loop; other site
657323000031	H-loop/switch region; other site
657323000032	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
657323000033	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
657323000034	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
657323000035	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
657323000036	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
657323000037	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
657323000038	NAD binding site [chemical binding]; other site
657323000039	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
657323000040	nudix motif; other site
657323000041	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
657323000042	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
657323000043	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
657323000044	active site
657323000045	catalytic motif [active]
657323000046	Zn binding site [ion binding]; other site
657323000047	serine O-acetyltransferase; Region: cysE; TIGR01172
657323000048	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
657323000049	trimer interface [polypeptide binding]; other site
657323000050	active site
657323000051	substrate binding site [chemical binding]; other site
657323000052	CoA binding site [chemical binding]; other site
657323000053	Uncharacterized conserved protein [Function unknown]; Region: COG2155
657323000054	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
657323000055	4-alpha-glucanotransferase; Provisional; Region: PRK14508
657323000056	Predicted integral membrane protein [Function unknown]; Region: COG5652
657323000057	Thymidylate synthase; Region: Thymidylat_synt; pfam00303
657323000058	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
657323000059	dimerization interface [polypeptide binding]; other site
657323000060	active site
657323000061	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
657323000062	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
657323000063	folate binding site [chemical binding]; other site
657323000064	NADP+ binding site [chemical binding]; other site
657323000065	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
657323000066	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
657323000067	homodimer interface [polypeptide binding]; other site
657323000068	substrate-cofactor binding pocket; other site
657323000069	catalytic residue [active]
657323000070	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
657323000071	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
657323000072	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
657323000073	GcpE protein; Region: GcpE; pfam04551
657323000074	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
657323000075	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
657323000076	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
657323000077	generic binding surface I; other site
657323000078	DNA polymerase III, alpha chain, Gram-positive type; Region: polC_Gram_pos; TIGR01405
657323000079	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
657323000080	active site
657323000081	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
657323000082	active site
657323000083	catalytic site [active]
657323000084	substrate binding site [chemical binding]; other site
657323000085	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
657323000086	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
657323000087	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
657323000088	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323000089	non-specific DNA binding site [nucleotide binding]; other site
657323000090	salt bridge; other site
657323000091	sequence-specific DNA binding site [nucleotide binding]; other site
657323000092	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
657323000093	DNA protecting protein DprA; Region: dprA; TIGR00732
657323000094	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
657323000095	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
657323000096	active site
657323000097	interdomain interaction site; other site
657323000098	putative metal-binding site [ion binding]; other site
657323000099	nucleotide binding site [chemical binding]; other site
657323000100	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
657323000101	domain I; other site
657323000102	phosphate binding site [ion binding]; other site
657323000103	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
657323000104	domain III; other site
657323000105	DNA binding groove [nucleotide binding]
657323000106	catalytic site [active]
657323000107	nucleotide binding site [chemical binding]; other site
657323000108	domain II; other site
657323000109	domain IV; other site
657323000110	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
657323000111	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
657323000112	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
657323000113	transcriptional repressor CodY; Validated; Region: PRK04158
657323000114	CodY GAF-like domain; Region: CodY; pfam06018
657323000115	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
657323000116	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
657323000117	oligomerisation interface [polypeptide binding]; other site
657323000118	mobile loop; other site
657323000119	roof hairpin; other site
657323000120	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
657323000121	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
657323000122	ring oligomerisation interface [polypeptide binding]; other site
657323000123	ATP/Mg binding site [chemical binding]; other site
657323000124	stacking interactions; other site
657323000125	hinge regions; other site
657323000126	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
657323000127	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
657323000128	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
657323000129	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
657323000130	active site
657323000131	IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330
657323000132	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
657323000133	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
657323000134	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
657323000135	N-acetyl-D-glucosamine binding site [chemical binding]; other site
657323000136	catalytic residue [active]
657323000137	3D domain; Region: 3D; cl01439
657323000138	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
657323000139	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
657323000140	dimer interface [polypeptide binding]; other site
657323000141	active site
657323000142	metal binding site [ion binding]; metal-binding site
657323000143	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
657323000144	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
657323000145	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
657323000146	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
657323000147	catalytic residues [active]
657323000148	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
657323000149	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
657323000150	ligand binding site [chemical binding]; other site
657323000151	flexible hinge region; other site
657323000152	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
657323000153	putative switch regulator; other site
657323000154	non-specific DNA interactions [nucleotide binding]; other site
657323000155	DNA binding site [nucleotide binding]
657323000156	sequence specific DNA binding site [nucleotide binding]; other site
657323000157	putative cAMP binding site [chemical binding]; other site
657323000158	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
657323000159	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
657323000160	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323000161	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657323000162	dimerization interface [polypeptide binding]; other site
657323000163	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323000164	dimer interface [polypeptide binding]; other site
657323000165	phosphorylation site [posttranslational modification]
657323000166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323000167	ATP binding site [chemical binding]; other site
657323000168	Mg2+ binding site [ion binding]; other site
657323000169	G-X-G motif; other site
657323000170	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323000171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323000172	active site
657323000173	phosphorylation site [posttranslational modification]
657323000174	intermolecular recognition site; other site
657323000175	dimerization interface [polypeptide binding]; other site
657323000176	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323000177	DNA binding site [nucleotide binding]
657323000178	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
657323000179	MutS domain III; Region: MutS_III; pfam05192
657323000180	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
657323000181	Walker A/P-loop; other site
657323000182	ATP binding site [chemical binding]; other site
657323000183	Q-loop/lid; other site
657323000184	ABC transporter signature motif; other site
657323000185	Walker B; other site
657323000186	D-loop; other site
657323000187	H-loop/switch region; other site
657323000188	Smr domain; Region: Smr; pfam01713
657323000189	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
657323000190	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
657323000191	generic binding surface II; other site
657323000192	generic binding surface I; other site
657323000193	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657323000194	Zn2+ binding site [ion binding]; other site
657323000195	Mg2+ binding site [ion binding]; other site
657323000196	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
657323000197	TRAM domain; Region: TRAM; cl01282
657323000198	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323000199	S-adenosylmethionine binding site [chemical binding]; other site
657323000200	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
657323000201	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
657323000202	Transposase; Region: HTH_Tnp_1; cl17663
657323000203	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
657323000204	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
657323000205	Transposase; Region: DEDD_Tnp_IS110; pfam01548
657323000206	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
657323000207	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
657323000208	putative active site [active]
657323000209	PAS fold; Region: PAS_3; pfam08447
657323000210	heme pocket [chemical binding]; other site
657323000211	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323000212	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323000213	dimer interface [polypeptide binding]; other site
657323000214	phosphorylation site [posttranslational modification]
657323000215	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323000216	ATP binding site [chemical binding]; other site
657323000217	Mg2+ binding site [ion binding]; other site
657323000218	G-X-G motif; other site
657323000219	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
657323000220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323000221	active site
657323000222	phosphorylation site [posttranslational modification]
657323000223	intermolecular recognition site; other site
657323000224	dimerization interface [polypeptide binding]; other site
657323000225	Response regulator receiver domain; Region: Response_reg; pfam00072
657323000226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323000227	active site
657323000228	phosphorylation site [posttranslational modification]
657323000229	intermolecular recognition site; other site
657323000230	dimerization interface [polypeptide binding]; other site
657323000231	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
657323000232	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323000233	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323000234	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323000235	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323000236	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657323000237	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
657323000238	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
657323000239	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
657323000240	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
657323000241	Phosphotransferase enzyme family; Region: APH; pfam01636
657323000242	Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508
657323000243	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
657323000244	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128
657323000245	conserved cys residue [active]
657323000246	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
657323000247	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
657323000248	Src homology 2 (SH2) domain; Region: SH2; cl15255
657323000249	phosphotyrosine binding pocket [polypeptide binding]; other site
657323000250	hydrophobic binding pocket [polypeptide binding]; other site
657323000251	Region found in RelA / SpoT proteins; Region: RelA_SpoT; smart00954
657323000252	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323000253	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657323000254	enolase; Provisional; Region: eno; PRK00077
657323000255	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
657323000256	dimer interface [polypeptide binding]; other site
657323000257	metal binding site [ion binding]; metal-binding site
657323000258	substrate binding pocket [chemical binding]; other site
657323000259	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
657323000260	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
657323000261	Protein of unknown function DUF111; Region: DUF111; pfam01969
657323000262	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323000263	DNA binding site [nucleotide binding]
657323000264	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
657323000265	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657323000266	ligand binding site [chemical binding]; other site
657323000267	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
657323000268	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
657323000269	substrate binding site [chemical binding]; other site
657323000270	ATP binding site [chemical binding]; other site
657323000271	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
657323000272	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
657323000273	PYR/PP interface [polypeptide binding]; other site
657323000274	dimer interface [polypeptide binding]; other site
657323000275	TPP binding site [chemical binding]; other site
657323000276	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
657323000277	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
657323000278	TPP-binding site; other site
657323000279	KduI/IolB family; Region: KduI; pfam04962
657323000280	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
657323000281	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
657323000282	putative active site [active]
657323000283	metal binding site [ion binding]; metal-binding site
657323000284	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
657323000285	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
657323000286	ligand binding site [chemical binding]; other site
657323000287	MFS/sugar transport protein; Region: MFS_2; pfam13347
657323000288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657323000289	putative substrate translocation pore; other site
657323000290	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
657323000291	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657323000292	dimerization interface [polypeptide binding]; other site
657323000293	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
657323000294	Histidine kinase; Region: His_kinase; pfam06580
657323000295	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323000296	ATP binding site [chemical binding]; other site
657323000297	Mg2+ binding site [ion binding]; other site
657323000298	G-X-G motif; other site
657323000299	Response regulator receiver domain; Region: Response_reg; pfam00072
657323000300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323000301	active site
657323000302	phosphorylation site [posttranslational modification]
657323000303	intermolecular recognition site; other site
657323000304	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323000305	DNA binding site [nucleotide binding]
657323000306	domain linker motif; other site
657323000307	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
657323000308	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657323000309	ligand binding site [chemical binding]; other site
657323000310	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
657323000311	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
657323000312	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
657323000313	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
657323000314	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
657323000315	intersubunit interface [polypeptide binding]; other site
657323000316	active site
657323000317	zinc binding site [ion binding]; other site
657323000318	Na+ binding site [ion binding]; other site
657323000319	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
657323000320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323000321	S-adenosylmethionine binding site [chemical binding]; other site
657323000322	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
657323000323	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
657323000324	nucleotide binding site [chemical binding]; other site
657323000325	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
657323000326	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234
657323000327	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
657323000328	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
657323000329	active site
657323000330	catalytic site [active]
657323000331	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
657323000332	active site residue [active]
657323000333	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
657323000334	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
657323000335	Ligand Binding Site [chemical binding]; other site
657323000336	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
657323000337	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
657323000338	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
657323000339	sporulation sigma factor SigG; Reviewed; Region: PRK08215
657323000340	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657323000341	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
657323000342	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657323000343	DNA binding residues [nucleotide binding]
657323000344	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
657323000345	glutamate dehydrogenase; Provisional; Region: PRK09414
657323000346	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
657323000347	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
657323000348	NAD(P) binding site [chemical binding]; other site
657323000349	aminotransferase AlaT; Validated; Region: PRK09265
657323000350	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657323000351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323000352	homodimer interface [polypeptide binding]; other site
657323000353	catalytic residue [active]
657323000354	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
657323000355	dimer interface [polypeptide binding]; other site
657323000356	Citrate synthase; Region: Citrate_synt; pfam00285
657323000357	active site
657323000358	citrylCoA binding site [chemical binding]; other site
657323000359	oxalacetate/citrate binding site [chemical binding]; other site
657323000360	coenzyme A binding site [chemical binding]; other site
657323000361	catalytic triad [active]
657323000362	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
657323000363	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323000364	active site
657323000365	motif I; other site
657323000366	motif II; other site
657323000367	shikimate kinase; Reviewed; Region: aroK; PRK00131
657323000368	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
657323000369	ADP binding site [chemical binding]; other site
657323000370	magnesium binding site [ion binding]; other site
657323000371	putative shikimate binding site; other site
657323000372	elongation factor P; Validated; Region: PRK00529
657323000373	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
657323000374	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
657323000375	RNA binding site [nucleotide binding]; other site
657323000376	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
657323000377	RNA binding site [nucleotide binding]; other site
657323000378	acyl carrier protein; Provisional; Region: acpP; PRK00982
657323000379	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
657323000380	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
657323000381	active site
657323000382	HIGH motif; other site
657323000383	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
657323000384	active site
657323000385	KMSKS motif; other site
657323000386	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
657323000387	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
657323000388	FMN-binding domain; Region: FMN_bind; cl01081
657323000389	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
657323000390	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657323000391	Walker A motif; other site
657323000392	ATP binding site [chemical binding]; other site
657323000393	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
657323000394	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
657323000395	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
657323000396	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
657323000397	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
657323000398	active site
657323000399	catalytic residues [active]
657323000400	DNA binding site [nucleotide binding]
657323000401	Int/Topo IB signature motif; other site
657323000402	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
657323000403	Response regulator receiver domain; Region: Response_reg; pfam00072
657323000404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323000405	active site
657323000406	phosphorylation site [posttranslational modification]
657323000407	intermolecular recognition site; other site
657323000408	LytTr DNA-binding domain; Region: LytTR; smart00850
657323000409	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
657323000410	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323000411	salt bridge; other site
657323000412	non-specific DNA binding site [nucleotide binding]; other site
657323000413	sequence-specific DNA binding site [nucleotide binding]; other site
657323000414	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
657323000415	Asp23 family; Region: Asp23; pfam03780
657323000416	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
657323000417	putative RNA binding site [nucleotide binding]; other site
657323000418	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
657323000419	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
657323000420	generic binding surface II; other site
657323000421	generic binding surface I; other site
657323000422	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
657323000423	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
657323000424	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
657323000425	substrate binding pocket [chemical binding]; other site
657323000426	chain length determination region; other site
657323000427	substrate-Mg2+ binding site; other site
657323000428	catalytic residues [active]
657323000429	aspartate-rich region 1; other site
657323000430	active site lid residues [active]
657323000431	aspartate-rich region 2; other site
657323000432	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
657323000433	TPP-binding site; other site
657323000434	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
657323000435	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
657323000436	RNA binding surface [nucleotide binding]; other site
657323000437	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
657323000438	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
657323000439	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
657323000440	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
657323000441	AAA domain; Region: AAA_23; pfam13476
657323000442	Walker A/P-loop; other site
657323000443	ATP binding site [chemical binding]; other site
657323000444	Q-loop/lid; other site
657323000445	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
657323000446	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
657323000447	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
657323000448	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
657323000449	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323000450	active site
657323000451	phosphorylation site [posttranslational modification]
657323000452	intermolecular recognition site; other site
657323000453	dimerization interface [polypeptide binding]; other site
657323000454	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
657323000455	glycogen synthase; Provisional; Region: glgA; PRK00654
657323000456	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
657323000457	ADP-binding pocket [chemical binding]; other site
657323000458	homodimer interface [polypeptide binding]; other site
657323000459	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
657323000460	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
657323000461	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
657323000462	G1 box; other site
657323000463	GTP/Mg2+ binding site [chemical binding]; other site
657323000464	Switch I region; other site
657323000465	G2 box; other site
657323000466	G3 box; other site
657323000467	Switch II region; other site
657323000468	G4 box; other site
657323000469	G5 box; other site
657323000470	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
657323000471	Nucleoside recognition; Region: Gate; pfam07670
657323000472	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
657323000473	Nucleoside recognition; Region: Gate; pfam07670
657323000474	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
657323000475	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
657323000476	Flavoprotein; Region: Flavoprotein; pfam02441
657323000477	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323000478	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
657323000479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323000480	Walker A motif; other site
657323000481	ATP binding site [chemical binding]; other site
657323000482	Walker B motif; other site
657323000483	arginine finger; other site
657323000484	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323000485	DNA binding site [nucleotide binding]
657323000486	domain linker motif; other site
657323000487	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
657323000488	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657323000489	ligand binding site [chemical binding]; other site
657323000490	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
657323000491	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
657323000492	trimer interface [polypeptide binding]; other site
657323000493	putative metal binding site [ion binding]; other site
657323000494	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
657323000495	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
657323000496	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657323000497	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323000498	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323000499	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
657323000500	Cache domain; Region: Cache_1; pfam02743
657323000501	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657323000502	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657323000503	metal binding site [ion binding]; metal-binding site
657323000504	active site
657323000505	I-site; other site
657323000506	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323000507	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144
657323000508	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
657323000509	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657323000510	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657323000511	catalytic residue [active]
657323000512	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
657323000513	spermidine synthase; Provisional; Region: PRK00811
657323000514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323000515	S-adenosylmethionine binding site [chemical binding]; other site
657323000516	agmatinase; Region: agmatinase; TIGR01230
657323000517	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
657323000518	putative active site [active]
657323000519	Mn binding site [ion binding]; other site
657323000520	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
657323000521	NAD(P) binding pocket [chemical binding]; other site
657323000522	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
657323000523	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
657323000524	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
657323000525	dimer interface [polypeptide binding]; other site
657323000526	active site
657323000527	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
657323000528	catalytic residues [active]
657323000529	substrate binding site [chemical binding]; other site
657323000530	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
657323000531	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
657323000532	isoaspartyl dipeptidase; Provisional; Region: PRK10657
657323000533	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
657323000534	active site
657323000535	Formaldehyde dehydrogenases; Region: FDH_like; cd05278
657323000536	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
657323000537	catalytic Zn binding site [ion binding]; other site
657323000538	NAD(P) binding site [chemical binding]; other site
657323000539	structural Zn binding site [ion binding]; other site
657323000540	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
657323000541	MarR family; Region: MarR_2; pfam12802
657323000542	Predicted membrane protein [Function unknown]; Region: COG2364
657323000543	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
657323000544	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
657323000545	shikimate kinase II; Reviewed; Region: aroL; cl17327
657323000546	Helix-turn-helix domain; Region: HTH_18; pfam12833
657323000547	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323000548	Transcriptional regulator; Region: Rrf2; cl17282
657323000549	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
657323000550	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
657323000551	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
657323000552	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
657323000553	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
657323000554	P-loop; other site
657323000555	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657323000556	MoxR-like ATPases [General function prediction only]; Region: COG0714
657323000557	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
657323000558	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
657323000559	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
657323000560	transmembrane helices; other site
657323000561	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
657323000562	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657323000563	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323000564	Helix-turn-helix domain; Region: HTH_18; pfam12833
657323000565	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323000566	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323000567	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657323000568	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657323000569	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323000570	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
657323000571	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323000572	Walker A motif; other site
657323000573	ATP binding site [chemical binding]; other site
657323000574	Walker B motif; other site
657323000575	AAA domain; Region: AAA_21; pfam13304
657323000576	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000577	Walker B; other site
657323000578	D-loop; other site
657323000579	H-loop/switch region; other site
657323000580	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
657323000581	putative active site [active]
657323000582	putative metal-binding site [ion binding]; other site
657323000583	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
657323000584	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
657323000585	active site
657323000586	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657323000587	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323000588	non-specific DNA binding site [nucleotide binding]; other site
657323000589	salt bridge; other site
657323000590	sequence-specific DNA binding site [nucleotide binding]; other site
657323000591	Domain of unknown function (DUF955); Region: DUF955; pfam06114
657323000592	Phage-related protein [Function unknown]; Region: COG4695
657323000593	Phage portal protein; Region: Phage_portal; pfam04860
657323000594	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
657323000595	Phage capsid family; Region: Phage_capsid; pfam05065
657323000596	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
657323000597	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
657323000598	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
657323000599	membrane protein P6; Region: PHA01399
657323000600	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
657323000601	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657323000602	Coenzyme A binding pocket [chemical binding]; other site
657323000603	MobA/MobL family; Region: MobA_MobL; pfam03389
657323000604	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323000605	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323000606	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
657323000607	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
657323000608	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323000609	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657323000610	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000611	Walker A/P-loop; other site
657323000612	ATP binding site [chemical binding]; other site
657323000613	Q-loop/lid; other site
657323000614	ABC transporter signature motif; other site
657323000615	Walker B; other site
657323000616	D-loop; other site
657323000617	H-loop/switch region; other site
657323000618	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323000619	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657323000620	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000621	Walker A/P-loop; other site
657323000622	ATP binding site [chemical binding]; other site
657323000623	Q-loop/lid; other site
657323000624	ABC transporter signature motif; other site
657323000625	Walker B; other site
657323000626	D-loop; other site
657323000627	H-loop/switch region; other site
657323000628	Holin family; Region: Phage_holin_4; pfam05105
657323000629	N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510
657323000630	substrate binding site [chemical binding]; other site
657323000631	amidase catalytic site [active]
657323000632	Zn binding residues [ion binding]; other site
657323000633	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
657323000634	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
657323000635	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
657323000636	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323000637	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323000638	DNA binding site [nucleotide binding]
657323000639	Int/Topo IB signature motif; other site
657323000640	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
657323000641	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657323000642	Magnesium ion binding site [ion binding]; other site
657323000643	ParB-like nuclease domain; Region: ParB; smart00470
657323000644	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
657323000645	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
657323000646	dimer interface [polypeptide binding]; other site
657323000647	ssDNA binding site [nucleotide binding]; other site
657323000648	tetramer (dimer of dimers) interface [polypeptide binding]; other site
657323000649	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
657323000650	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
657323000651	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
657323000652	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
657323000653	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
657323000654	Maff2 family; Region: Maff2; pfam12750
657323000655	AAA-like domain; Region: AAA_10; pfam12846
657323000656	Domain of unknown function DUF87; Region: DUF87; pfam01935
657323000657	Protein of unknown function (DUF3789); Region: DUF3789; pfam12664
657323000658	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
657323000659	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
657323000660	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
657323000661	active site
657323000662	putative interdomain interaction site [polypeptide binding]; other site
657323000663	putative metal-binding site [ion binding]; other site
657323000664	putative nucleotide binding site [chemical binding]; other site
657323000665	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
657323000666	domain I; other site
657323000667	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
657323000668	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
657323000669	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
657323000670	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
657323000671	Walker A/P-loop; other site
657323000672	ATP binding site [chemical binding]; other site
657323000673	Q-loop/lid; other site
657323000674	ABC transporter signature motif; other site
657323000675	Walker B; other site
657323000676	D-loop; other site
657323000677	H-loop/switch region; other site
657323000678	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000679	Walker A/P-loop; other site
657323000680	ATP binding site [chemical binding]; other site
657323000681	Q-loop/lid; other site
657323000682	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000683	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
657323000684	ABC transporter signature motif; other site
657323000685	Walker B; other site
657323000686	D-loop; other site
657323000687	H-loop/switch region; other site
657323000688	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323000689	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323000690	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323000691	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657323000692	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000693	Walker A/P-loop; other site
657323000694	ATP binding site [chemical binding]; other site
657323000695	Q-loop/lid; other site
657323000696	ABC transporter signature motif; other site
657323000697	Walker B; other site
657323000698	D-loop; other site
657323000699	H-loop/switch region; other site
657323000700	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323000701	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657323000702	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000703	Walker A/P-loop; other site
657323000704	ATP binding site [chemical binding]; other site
657323000705	Q-loop/lid; other site
657323000706	ABC transporter signature motif; other site
657323000707	Walker B; other site
657323000708	D-loop; other site
657323000709	H-loop/switch region; other site
657323000710	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323000711	non-specific DNA binding site [nucleotide binding]; other site
657323000712	salt bridge; other site
657323000713	sequence-specific DNA binding site [nucleotide binding]; other site
657323000714	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657323000715	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323000716	non-specific DNA binding site [nucleotide binding]; other site
657323000717	salt bridge; other site
657323000718	sequence-specific DNA binding site [nucleotide binding]; other site
657323000719	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
657323000720	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657323000721	DNA binding residues [nucleotide binding]
657323000722	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657323000723	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657323000724	catalytic residues [active]
657323000725	catalytic nucleophile [active]
657323000726	Recombinase; Region: Recombinase; pfam07508
657323000727	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657323000728	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657323000729	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657323000730	catalytic residues [active]
657323000731	catalytic nucleophile [active]
657323000732	Recombinase; Region: Recombinase; pfam07508
657323000733	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657323000734	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657323000735	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657323000736	catalytic residues [active]
657323000737	catalytic nucleophile [active]
657323000738	Recombinase; Region: Recombinase; pfam07508
657323000739	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323000740	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
657323000741	Recombinase; Region: Recombinase; pfam07508
657323000742	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657323000743	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
657323000744	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657323000745	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
657323000746	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657323000747	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
657323000748	Walker A/P-loop; other site
657323000749	ATP binding site [chemical binding]; other site
657323000750	Q-loop/lid; other site
657323000751	ABC transporter signature motif; other site
657323000752	Walker B; other site
657323000753	D-loop; other site
657323000754	H-loop/switch region; other site
657323000755	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
657323000756	MobA/MobL family; Region: MobA_MobL; pfam03389
657323000757	CHC2 zinc finger; Region: zf-CHC2; cl17510
657323000758	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
657323000759	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
657323000760	active site
657323000761	metal binding site [ion binding]; metal-binding site
657323000762	interdomain interaction site; other site
657323000763	AAA domain; Region: AAA_25; pfam13481
657323000764	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657323000765	ATP binding site [chemical binding]; other site
657323000766	Walker A motif; other site
657323000767	Walker B motif; other site
657323000768	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
657323000769	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
657323000770	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
657323000771	Maff2 family; Region: Maff2; pfam12750
657323000772	PrgI family protein; Region: PrgI; pfam12666
657323000773	AAA-like domain; Region: AAA_10; pfam12846
657323000774	Domain of unknown function DUF87; Region: DUF87; pfam01935
657323000775	AAA-like domain; Region: AAA_10; pfam12846
657323000776	Cna protein B-type domain; Region: Cna_B; pfam05738
657323000777	Methyltransferase domain; Region: Methyltransf_26; pfam13659
657323000778	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
657323000779	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
657323000780	Domain of unknown function (DUF4319); Region: DUF4319; pfam14203
657323000781	YodL-like; Region: YodL; pfam14191
657323000782	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
657323000783	Helix-turn-helix domain; Region: HTH_18; pfam12833
657323000784	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323000785	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
657323000786	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
657323000787	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
657323000788	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
657323000789	Walker A/P-loop; other site
657323000790	ATP binding site [chemical binding]; other site
657323000791	Q-loop/lid; other site
657323000792	ABC transporter signature motif; other site
657323000793	Walker B; other site
657323000794	D-loop; other site
657323000795	H-loop/switch region; other site
657323000796	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
657323000797	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000798	Walker A/P-loop; other site
657323000799	ATP binding site [chemical binding]; other site
657323000800	Q-loop/lid; other site
657323000801	ABC transporter signature motif; other site
657323000802	Walker B; other site
657323000803	D-loop; other site
657323000804	H-loop/switch region; other site
657323000805	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323000806	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000807	Walker A/P-loop; other site
657323000808	ATP binding site [chemical binding]; other site
657323000809	Q-loop/lid; other site
657323000810	ABC transporter signature motif; other site
657323000811	Walker B; other site
657323000812	D-loop; other site
657323000813	H-loop/switch region; other site
657323000814	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657323000815	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323000816	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000817	Walker A/P-loop; other site
657323000818	ATP binding site [chemical binding]; other site
657323000819	Q-loop/lid; other site
657323000820	ABC transporter signature motif; other site
657323000821	Walker B; other site
657323000822	D-loop; other site
657323000823	H-loop/switch region; other site
657323000824	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
657323000825	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
657323000826	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
657323000827	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323000828	non-specific DNA binding site [nucleotide binding]; other site
657323000829	salt bridge; other site
657323000830	sequence-specific DNA binding site [nucleotide binding]; other site
657323000831	Helix-turn-helix domain; Region: HTH_17; pfam12728
657323000832	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323000833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323000834	active site
657323000835	phosphorylation site [posttranslational modification]
657323000836	intermolecular recognition site; other site
657323000837	dimerization interface [polypeptide binding]; other site
657323000838	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323000839	DNA binding site [nucleotide binding]
657323000840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323000841	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323000842	dimer interface [polypeptide binding]; other site
657323000843	phosphorylation site [posttranslational modification]
657323000844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323000845	ATP binding site [chemical binding]; other site
657323000846	Mg2+ binding site [ion binding]; other site
657323000847	G-X-G motif; other site
657323000848	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
657323000849	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000850	Walker A/P-loop; other site
657323000851	ATP binding site [chemical binding]; other site
657323000852	Q-loop/lid; other site
657323000853	ABC transporter signature motif; other site
657323000854	Walker B; other site
657323000855	D-loop; other site
657323000856	H-loop/switch region; other site
657323000857	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323000858	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323000859	DNA binding site [nucleotide binding]
657323000860	Domain of unknown function (DUF4319); Region: DUF4319; pfam14203
657323000861	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
657323000862	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
657323000863	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
657323000864	Penicillinase repressor; Region: Pencillinase_R; pfam03965
657323000865	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
657323000866	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323000867	non-specific DNA binding site [nucleotide binding]; other site
657323000868	salt bridge; other site
657323000869	sequence-specific DNA binding site [nucleotide binding]; other site
657323000870	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
657323000871	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657323000872	DNA binding residues [nucleotide binding]
657323000873	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323000874	DNA binding site [nucleotide binding]
657323000875	active site
657323000876	Int/Topo IB signature motif; other site
657323000877	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
657323000878	Low molecular weight phosphatase family; Region: LMWPc; cd00115
657323000879	active site
657323000880	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
657323000881	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323000882	Walker A/P-loop; other site
657323000883	ATP binding site [chemical binding]; other site
657323000884	Q-loop/lid; other site
657323000885	ABC transporter signature motif; other site
657323000886	Walker B; other site
657323000887	D-loop; other site
657323000888	H-loop/switch region; other site
657323000889	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
657323000890	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
657323000891	TM-ABC transporter signature motif; other site
657323000892	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
657323000893	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657323000894	zinc binding site [ion binding]; other site
657323000895	putative ligand binding site [chemical binding]; other site
657323000896	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
657323000897	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
657323000898	active site
657323000899	metal binding site [ion binding]; metal-binding site
657323000900	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
657323000901	Sporulation related domain; Region: SPOR; pfam05036
657323000902	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
657323000903	putative active site [active]
657323000904	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
657323000905	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
657323000906	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
657323000907	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
657323000908	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
657323000909	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
657323000910	Protein export membrane protein; Region: SecD_SecF; cl14618
657323000911	Protein export membrane protein; Region: SecD_SecF; pfam02355
657323000912	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
657323000913	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657323000914	active site
657323000915	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
657323000916	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657323000917	Zn2+ binding site [ion binding]; other site
657323000918	Mg2+ binding site [ion binding]; other site
657323000919	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
657323000920	synthetase active site [active]
657323000921	NTP binding site [chemical binding]; other site
657323000922	metal binding site [ion binding]; metal-binding site
657323000923	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
657323000924	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
657323000925	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
657323000926	histidyl-tRNA synthetase; Region: hisS; TIGR00442
657323000927	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
657323000928	dimer interface [polypeptide binding]; other site
657323000929	motif 1; other site
657323000930	active site
657323000931	motif 2; other site
657323000932	motif 3; other site
657323000933	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
657323000934	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
657323000935	dimer interface [polypeptide binding]; other site
657323000936	anticodon binding site; other site
657323000937	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
657323000938	homodimer interface [polypeptide binding]; other site
657323000939	motif 1; other site
657323000940	active site
657323000941	motif 2; other site
657323000942	GAD domain; Region: GAD; pfam02938
657323000943	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
657323000944	motif 3; other site
657323000945	Predicted permeases [General function prediction only]; Region: COG0730
657323000946	hypothetical protein; Provisional; Region: PRK10621
657323000947	hypothetical protein; Provisional; Region: PRK10621
657323000948	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
657323000949	Chain length determinant protein; Region: Wzz; cl15801
657323000950	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
657323000951	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657323000952	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
657323000953	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
657323000954	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657323000955	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657323000956	Walker A/P-loop; other site
657323000957	ATP binding site [chemical binding]; other site
657323000958	Q-loop/lid; other site
657323000959	ABC transporter signature motif; other site
657323000960	Walker B; other site
657323000961	D-loop; other site
657323000962	H-loop/switch region; other site
657323000963	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
657323000964	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
657323000965	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657323000966	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
657323000967	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
657323000968	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
657323000969	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
657323000970	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
657323000971	EDD domain protein, DegV family; Region: DegV; TIGR00762
657323000972	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
657323000973	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
657323000974	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
657323000975	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657323000976	active site
657323000977	HIGH motif; other site
657323000978	nucleotide binding site [chemical binding]; other site
657323000979	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
657323000980	KMSK motif region; other site
657323000981	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
657323000982	tRNA binding surface [nucleotide binding]; other site
657323000983	anticodon binding site; other site
657323000984	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
657323000985	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
657323000986	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323000987	motif II; other site
657323000988	Predicted transcriptional regulators [Transcription]; Region: COG1725
657323000989	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657323000990	DNA-binding site [nucleotide binding]; DNA binding site
657323000991	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
657323000992	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
657323000993	Walker A/P-loop; other site
657323000994	ATP binding site [chemical binding]; other site
657323000995	Q-loop/lid; other site
657323000996	ABC transporter signature motif; other site
657323000997	Walker B; other site
657323000998	D-loop; other site
657323000999	H-loop/switch region; other site
657323001000	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
657323001001	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
657323001002	rRNA interaction site [nucleotide binding]; other site
657323001003	S8 interaction site; other site
657323001004	putative laminin-1 binding site; other site
657323001005	elongation factor Ts; Provisional; Region: tsf; PRK09377
657323001006	UBA/TS-N domain; Region: UBA; pfam00627
657323001007	Elongation factor TS; Region: EF_TS; pfam00889
657323001008	Elongation factor TS; Region: EF_TS; pfam00889
657323001009	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657323001010	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323001011	non-specific DNA binding site [nucleotide binding]; other site
657323001012	salt bridge; other site
657323001013	sequence-specific DNA binding site [nucleotide binding]; other site
657323001014	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
657323001015	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
657323001016	catalytic motif [active]
657323001017	Zn binding site [ion binding]; other site
657323001018	RibD C-terminal domain; Region: RibD_C; cl17279
657323001019	RibD C-terminal domain; Region: RibD_C; cl17279
657323001020	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
657323001021	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
657323001022	Lumazine binding domain; Region: Lum_binding; pfam00677
657323001023	Lumazine binding domain; Region: Lum_binding; pfam00677
657323001024	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
657323001025	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
657323001026	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
657323001027	dimerization interface [polypeptide binding]; other site
657323001028	active site
657323001029	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
657323001030	homopentamer interface [polypeptide binding]; other site
657323001031	active site
657323001032	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
657323001033	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323001034	motif II; other site
657323001035	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
657323001036	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657323001037	active site
657323001038	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323001039	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657323001040	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
657323001041	substrate binding site [chemical binding]; other site
657323001042	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
657323001043	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
657323001044	substrate binding site [chemical binding]; other site
657323001045	ligand binding site [chemical binding]; other site
657323001046	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
657323001047	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
657323001048	substrate binding site [chemical binding]; other site
657323001049	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
657323001050	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
657323001051	substrate binding site [chemical binding]; other site
657323001052	ligand binding site [chemical binding]; other site
657323001053	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
657323001054	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
657323001055	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
657323001056	Cysteine-rich domain; Region: CCG; pfam02754
657323001057	Cysteine-rich domain; Region: CCG; pfam02754
657323001058	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657323001059	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
657323001060	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
657323001061	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657323001062	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
657323001063	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
657323001064	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
657323001065	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
657323001066	FAD binding pocket [chemical binding]; other site
657323001067	FAD binding motif [chemical binding]; other site
657323001068	phosphate binding motif [ion binding]; other site
657323001069	beta-alpha-beta structure motif; other site
657323001070	NAD binding pocket [chemical binding]; other site
657323001071	Iron coordination center [ion binding]; other site
657323001072	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
657323001073	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657323001074	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
657323001075	L-aspartate oxidase; Provisional; Region: PRK06175
657323001076	FAD binding domain; Region: FAD_binding_2; pfam00890
657323001077	fumarate hydratase; Provisional; Region: PRK06246
657323001078	Fumarase C-terminus; Region: Fumerase_C; cl00795
657323001079	Fumarase C-terminus; Region: Fumerase_C; cl00795
657323001080	Fic/DOC family; Region: Fic; pfam02661
657323001081	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
657323001082	Methyltransferase domain; Region: Methyltransf_26; pfam13659
657323001083	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
657323001084	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
657323001085	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323001086	active site
657323001087	DNA binding site [nucleotide binding]
657323001088	Int/Topo IB signature motif; other site
657323001089	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
657323001090	Virulence protein [General function prediction only]; Region: COG3943
657323001091	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
657323001092	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
657323001093	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
657323001094	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
657323001095	ATP binding site [chemical binding]; other site
657323001096	putative Mg++ binding site [ion binding]; other site
657323001097	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
657323001098	nucleotide binding region [chemical binding]; other site
657323001099	ATP-binding site [chemical binding]; other site
657323001100	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
657323001101	MgtE intracellular N domain; Region: MgtE_N; pfam03448
657323001102	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
657323001103	Divalent cation transporter; Region: MgtE; pfam01769
657323001104	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
657323001105	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
657323001106	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
657323001107	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323001108	motif II; other site
657323001109	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
657323001110	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
657323001111	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
657323001112	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
657323001113	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
657323001114	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
657323001115	Peptidase family M28; Region: Peptidase_M28; pfam04389
657323001116	metal binding site [ion binding]; metal-binding site
657323001117	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
657323001118	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657323001119	Coenzyme A binding pocket [chemical binding]; other site
657323001120	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
657323001121	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
657323001122	Ca binding site [ion binding]; other site
657323001123	active site
657323001124	catalytic site [active]
657323001125	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
657323001126	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
657323001127	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
657323001128	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
657323001129	catalytic loop [active]
657323001130	iron binding site [ion binding]; other site
657323001131	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
657323001132	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
657323001133	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
657323001134	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
657323001135	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
657323001136	Mg++ binding site [ion binding]; other site
657323001137	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
657323001138	RNA binding surface [nucleotide binding]; other site
657323001139	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
657323001140	pseudouridine synthase; Region: TIGR00093
657323001141	active site
657323001142	Ligase N family; Region: LIGANc; smart00532
657323001143	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
657323001144	nucleotide binding pocket [chemical binding]; other site
657323001145	K-X-D-G motif; other site
657323001146	catalytic site [active]
657323001147	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
657323001148	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
657323001149	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
657323001150	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
657323001151	Dimer interface [polypeptide binding]; other site
657323001152	Homoserine O-succinyltransferase; Region: HTS; pfam04204
657323001153	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
657323001154	proposed active site lysine [active]
657323001155	conserved cys residue [active]
657323001156	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
657323001157	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
657323001158	substrate binding pocket [chemical binding]; other site
657323001159	dimer interface [polypeptide binding]; other site
657323001160	inhibitor binding site; inhibition site
657323001161	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
657323001162	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
657323001163	B12 binding site [chemical binding]; other site
657323001164	cobalt ligand [ion binding]; other site
657323001165	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
657323001166	Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248
657323001167	Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248
657323001168	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
657323001169	N-acetyltransferase; Region: Acetyltransf_2; cl00949
657323001170	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
657323001171	MFS/sugar transport protein; Region: MFS_2; pfam13347
657323001172	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
657323001173	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
657323001174	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
657323001175	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
657323001176	putative deacylase active site [active]
657323001177	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
657323001178	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657323001179	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657323001180	ABC transporter; Region: ABC_tran_2; pfam12848
657323001181	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657323001182	Rrf2 family protein; Region: rrf2_super; TIGR00738
657323001183	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
657323001184	putative Zn2+ binding site [ion binding]; other site
657323001185	putative DNA binding site [nucleotide binding]; other site
657323001186	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
657323001187	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
657323001188	dimer interface [polypeptide binding]; other site
657323001189	PYR/PP interface [polypeptide binding]; other site
657323001190	TPP binding site [chemical binding]; other site
657323001191	substrate binding site [chemical binding]; other site
657323001192	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
657323001193	Domain of unknown function; Region: EKR; smart00890
657323001194	4Fe-4S binding domain; Region: Fer4_6; pfam12837
657323001195	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
657323001196	TPP-binding site [chemical binding]; other site
657323001197	dimer interface [polypeptide binding]; other site
657323001198	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
657323001199	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
657323001200	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
657323001201	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
657323001202	Ligand binding site; other site
657323001203	Putative Catalytic site; other site
657323001204	DXD motif; other site
657323001205	Predicted membrane protein [Function unknown]; Region: COG2246
657323001206	GtrA-like protein; Region: GtrA; pfam04138
657323001207	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
657323001208	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
657323001209	putative dimer interface [polypeptide binding]; other site
657323001210	active site pocket [active]
657323001211	putative cataytic base [active]
657323001212	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
657323001213	cobalamin synthase; Reviewed; Region: cobS; PRK00235
657323001214	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
657323001215	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
657323001216	catalytic core [active]
657323001217	Protein of unknown function (DUF975); Region: DUF975; cl10504
657323001218	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
657323001219	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
657323001220	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657323001221	active site
657323001222	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657323001223	BMC domain; Region: BMC; pfam00936
657323001224	Hexamer interface [polypeptide binding]; other site
657323001225	Hexagonal pore residue; other site
657323001226	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
657323001227	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
657323001228	Hexamer interface [polypeptide binding]; other site
657323001229	Hexagonal pore residue; other site
657323001230	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
657323001231	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323001232	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657323001233	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323001234	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
657323001235	Uncharacterized conserved protein [Function unknown]; Region: COG4198
657323001236	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
657323001237	synthetase active site [active]
657323001238	metal binding site [ion binding]; metal-binding site
657323001239	NTP binding site [chemical binding]; other site
657323001240	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
657323001241	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
657323001242	CPxP  motif; other site
657323001243	DsrE/DsrF-like family; Region: DrsE; pfam02635
657323001244	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
657323001245	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
657323001246	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657323001247	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
657323001248	XdhC Rossmann domain; Region: XdhC_C; pfam13478
657323001249	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
657323001250	Bacterial SH3 domain; Region: SH3_3; pfam08239
657323001251	S-ribosylhomocysteinase; Provisional; Region: PRK02260
657323001252	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
657323001253	active site
657323001254	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
657323001255	Flavoprotein; Region: Flavoprotein; pfam02441
657323001256	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
657323001257	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
657323001258	Type III pantothenate kinase; Region: Pan_kinase; cl17198
657323001259	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
657323001260	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
657323001261	active site
657323001262	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
657323001263	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
657323001264	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
657323001265	active site
657323001266	substrate binding site [chemical binding]; other site
657323001267	metal binding site [ion binding]; metal-binding site
657323001268	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
657323001269	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657323001270	active site
657323001271	Cupin domain; Region: Cupin_2; cl17218
657323001272	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
657323001273	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
657323001274	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
657323001275	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
657323001276	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
657323001277	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
657323001278	Probable Catalytic site; other site
657323001279	metal-binding site
657323001280	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
657323001281	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
657323001282	trimer interface [polypeptide binding]; other site
657323001283	active site
657323001284	substrate binding site [chemical binding]; other site
657323001285	CoA binding site [chemical binding]; other site
657323001286	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
657323001287	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
657323001288	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
657323001289	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
657323001290	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
657323001291	putative metal binding site [ion binding]; other site
657323001292	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657323001293	Coenzyme A binding pocket [chemical binding]; other site
657323001294	Predicted ATPase [General function prediction only]; Region: COG4637
657323001295	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323001296	Walker A/P-loop; other site
657323001297	ATP binding site [chemical binding]; other site
657323001298	Q-loop/lid; other site
657323001299	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
657323001300	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323001301	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
657323001302	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
657323001303	active site
657323001304	SAM binding site [chemical binding]; other site
657323001305	homodimer interface [polypeptide binding]; other site
657323001306	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
657323001307	active site
657323001308	SAM binding site [chemical binding]; other site
657323001309	homodimer interface [polypeptide binding]; other site
657323001310	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
657323001311	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
657323001312	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
657323001313	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
657323001314	active site
657323001315	SAM binding site [chemical binding]; other site
657323001316	homodimer interface [polypeptide binding]; other site
657323001317	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
657323001318	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
657323001319	active site
657323001320	putative homodimer interface [polypeptide binding]; other site
657323001321	SAM binding site [chemical binding]; other site
657323001322	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
657323001323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323001324	S-adenosylmethionine binding site [chemical binding]; other site
657323001325	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
657323001326	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
657323001327	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657323001328	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323001329	homodimer interface [polypeptide binding]; other site
657323001330	catalytic residue [active]
657323001331	cobyric acid synthase; Provisional; Region: PRK00784
657323001332	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657323001333	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
657323001334	catalytic triad [active]
657323001335	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
657323001336	Precorrin-8X methylmutase; Region: CbiC; pfam02570
657323001337	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
657323001338	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657323001339	DNA-binding site [nucleotide binding]; DNA binding site
657323001340	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657323001341	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657323001342	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
657323001343	substrate binding site [chemical binding]; other site
657323001344	ATP binding site [chemical binding]; other site
657323001345	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323001346	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657323001347	Walker A/P-loop; other site
657323001348	ATP binding site [chemical binding]; other site
657323001349	Q-loop/lid; other site
657323001350	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657323001351	ABC transporter signature motif; other site
657323001352	Walker B; other site
657323001353	D-loop; other site
657323001354	ABC transporter; Region: ABC_tran_2; pfam12848
657323001355	Uncharacterized conserved protein [Function unknown]; Region: COG0062
657323001356	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
657323001357	putative substrate binding site [chemical binding]; other site
657323001358	putative ATP binding site [chemical binding]; other site
657323001359	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
657323001360	alanine racemase; Reviewed; Region: alr; PRK00053
657323001361	active site
657323001362	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
657323001363	dimer interface [polypeptide binding]; other site
657323001364	substrate binding site [chemical binding]; other site
657323001365	catalytic residues [active]
657323001366	hypothetical protein; Validated; Region: PRK00110
657323001367	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
657323001368	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
657323001369	active site
657323001370	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
657323001371	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
657323001372	FAD binding pocket [chemical binding]; other site
657323001373	FAD binding motif [chemical binding]; other site
657323001374	phosphate binding motif [ion binding]; other site
657323001375	beta-alpha-beta structure motif; other site
657323001376	NAD binding pocket [chemical binding]; other site
657323001377	Iron coordination center [ion binding]; other site
657323001378	Bacitracin resistance protein BacA; Region: BacA; pfam02673
657323001379	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
657323001380	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
657323001381	oligomerisation interface [polypeptide binding]; other site
657323001382	mobile loop; other site
657323001383	roof hairpin; other site
657323001384	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657323001385	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657323001386	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
657323001387	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
657323001388	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
657323001389	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
657323001390	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
657323001391	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323001392	dimer interface [polypeptide binding]; other site
657323001393	conserved gate region; other site
657323001394	putative PBP binding loops; other site
657323001395	ABC-ATPase subunit interface; other site
657323001396	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657323001397	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
657323001398	Walker A/P-loop; other site
657323001399	ATP binding site [chemical binding]; other site
657323001400	Q-loop/lid; other site
657323001401	ABC transporter signature motif; other site
657323001402	Walker B; other site
657323001403	D-loop; other site
657323001404	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323001405	H-loop/switch region; other site
657323001406	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
657323001407	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
657323001408	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657323001409	Walker A/P-loop; other site
657323001410	ATP binding site [chemical binding]; other site
657323001411	Q-loop/lid; other site
657323001412	ABC transporter signature motif; other site
657323001413	Walker B; other site
657323001414	D-loop; other site
657323001415	H-loop/switch region; other site
657323001416	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
657323001417	LabA_like proteins; Region: LabA_like/DUF88; cl10034
657323001418	LabA_like proteins; Region: LabA_like/DUF88; cl10034
657323001419	putative metal binding site [ion binding]; other site
657323001420	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
657323001421	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
657323001422	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
657323001423	FMN binding site [chemical binding]; other site
657323001424	active site
657323001425	catalytic residues [active]
657323001426	substrate binding site [chemical binding]; other site
657323001427	Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050
657323001428	YabP family; Region: YabP; pfam07873
657323001429	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
657323001430	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
657323001431	PhoH-like protein; Region: PhoH; pfam02562
657323001432	metal-binding heat shock protein; Provisional; Region: PRK00016
657323001433	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
657323001434	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
657323001435	nucleotide binding site [chemical binding]; other site
657323001436	homotetrameric interface [polypeptide binding]; other site
657323001437	putative phosphate binding site [ion binding]; other site
657323001438	putative allosteric binding site; other site
657323001439	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
657323001440	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
657323001441	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
657323001442	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
657323001443	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
657323001444	putative catalytic cysteine [active]
657323001445	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
657323001446	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323001447	Walker A/P-loop; other site
657323001448	ATP binding site [chemical binding]; other site
657323001449	Q-loop/lid; other site
657323001450	ABC transporter signature motif; other site
657323001451	Walker B; other site
657323001452	D-loop; other site
657323001453	H-loop/switch region; other site
657323001454	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760
657323001455	heme-binding site [chemical binding]; other site
657323001456	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
657323001457	active site
657323001458	Zn binding site [ion binding]; other site
657323001459	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
657323001460	Catalytic site [active]
657323001461	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
657323001462	Cna protein B-type domain; Region: Cna_B; pfam05738
657323001463	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657323001464	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657323001465	metal binding site [ion binding]; metal-binding site
657323001466	active site
657323001467	I-site; other site
657323001468	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657323001469	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657323001470	metal binding site [ion binding]; metal-binding site
657323001471	active site
657323001472	I-site; other site
657323001473	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
657323001474	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
657323001475	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
657323001476	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
657323001477	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
657323001478	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657323001479	putative active site [active]
657323001480	putative metal binding site [ion binding]; other site
657323001481	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
657323001482	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
657323001483	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
657323001484	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
657323001485	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
657323001486	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
657323001487	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
657323001488	carboxyltransferase (CT) interaction site; other site
657323001489	biotinylation site [posttranslational modification]; other site
657323001490	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
657323001491	oxaloacetate decarboxylase; Provisional; Region: PRK12331
657323001492	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
657323001493	active site
657323001494	catalytic residues [active]
657323001495	metal binding site [ion binding]; metal-binding site
657323001496	homodimer binding site [polypeptide binding]; other site
657323001497	HI0933-like protein; Region: HI0933_like; pfam03486
657323001498	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
657323001499	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
657323001500	cytidylate kinase; Provisional; Region: cmk; PRK00023
657323001501	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
657323001502	CMP-binding site; other site
657323001503	The sites determining sugar specificity; other site
657323001504	LytB protein; Region: LYTB; cl00507
657323001505	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
657323001506	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
657323001507	RNA binding site [nucleotide binding]; other site
657323001508	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
657323001509	RNA binding site [nucleotide binding]; other site
657323001510	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
657323001511	RNA binding site [nucleotide binding]; other site
657323001512	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
657323001513	RNA binding site [nucleotide binding]; other site
657323001514	RNase_H superfamily; Region: RNase_H_2; pfam13482
657323001515	active site
657323001516	substrate binding site [chemical binding]; other site
657323001517	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
657323001518	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
657323001519	SLBB domain; Region: SLBB; pfam10531
657323001520	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
657323001521	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
657323001522	FMN-binding domain; Region: FMN_bind; cl01081
657323001523	electron transport complex RsxE subunit; Provisional; Region: PRK12405
657323001524	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
657323001525	Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878
657323001526	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657323001527	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
657323001528	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
657323001529	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
657323001530	active site
657323001531	HIGH motif; other site
657323001532	dimer interface [polypeptide binding]; other site
657323001533	KMSKS motif; other site
657323001534	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
657323001535	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
657323001536	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
657323001537	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323001538	Walker A motif; other site
657323001539	ATP binding site [chemical binding]; other site
657323001540	Walker B motif; other site
657323001541	arginine finger; other site
657323001542	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
657323001543	Cell division protein ZapA; Region: ZapA; pfam05164
657323001544	Collagenase; Region: DUF3656; pfam12392
657323001545	Peptidase family U32; Region: Peptidase_U32; cl03113
657323001546	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
657323001547	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
657323001548	active site
657323001549	Ap6A binding site [chemical binding]; other site
657323001550	nudix motif; other site
657323001551	metal binding site [ion binding]; metal-binding site
657323001552	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
657323001553	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; pfam09579
657323001554	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
657323001555	flavodoxin; Provisional; Region: PRK06242
657323001556	Asp23 family; Region: Asp23; pfam03780
657323001557	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
657323001558	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
657323001559	ssDNA binding site; other site
657323001560	generic binding surface II; other site
657323001561	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
657323001562	ATP binding site [chemical binding]; other site
657323001563	putative Mg++ binding site [ion binding]; other site
657323001564	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
657323001565	nucleotide binding region [chemical binding]; other site
657323001566	ATP-binding site [chemical binding]; other site
657323001567	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
657323001568	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
657323001569	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
657323001570	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
657323001571	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
657323001572	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
657323001573	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
657323001574	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
657323001575	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
657323001576	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
657323001577	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
657323001578	active site
657323001579	catalytic triad [active]
657323001580	oxyanion hole [active]
657323001581	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
657323001582	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
657323001583	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
657323001584	substrate binding site [chemical binding]; other site
657323001585	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
657323001586	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323001587	S-adenosylmethionine binding site [chemical binding]; other site
657323001588	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
657323001589	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
657323001590	active site
657323001591	(T/H)XGH motif; other site
657323001592	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
657323001593	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
657323001594	Nucleoside recognition; Region: Gate; pfam07670
657323001595	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
657323001596	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
657323001597	metal binding site [ion binding]; metal-binding site
657323001598	dimer interface [polypeptide binding]; other site
657323001599	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
657323001600	synthetase active site [active]
657323001601	NTP binding site [chemical binding]; other site
657323001602	metal binding site [ion binding]; metal-binding site
657323001603	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
657323001604	hypothetical protein; Provisional; Region: PRK00955
657323001605	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
657323001606	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
657323001607	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
657323001608	active site
657323001609	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
657323001610	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
657323001611	Catalytic site [active]
657323001612	Recombination protein U; Region: RecU; pfam03838
657323001613	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
657323001614	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
657323001615	dimer interface [polypeptide binding]; other site
657323001616	motif 1; other site
657323001617	active site
657323001618	motif 2; other site
657323001619	motif 3; other site
657323001620	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
657323001621	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
657323001622	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
657323001623	histidinol dehydrogenase; Region: hisD; TIGR00069
657323001624	NAD binding site [chemical binding]; other site
657323001625	dimerization interface [polypeptide binding]; other site
657323001626	product binding site; other site
657323001627	substrate binding site [chemical binding]; other site
657323001628	zinc binding site [ion binding]; other site
657323001629	catalytic residues [active]
657323001630	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
657323001631	putative active site pocket [active]
657323001632	4-fold oligomerization interface [polypeptide binding]; other site
657323001633	metal binding residues [ion binding]; metal-binding site
657323001634	3-fold/trimer interface [polypeptide binding]; other site
657323001635	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
657323001636	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
657323001637	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
657323001638	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
657323001639	metal binding site [ion binding]; metal-binding site
657323001640	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
657323001641	active site
657323001642	Zn binding site [ion binding]; other site
657323001643	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
657323001644	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
657323001645	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
657323001646	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657323001647	Walker A/P-loop; other site
657323001648	ATP binding site [chemical binding]; other site
657323001649	Q-loop/lid; other site
657323001650	ABC transporter signature motif; other site
657323001651	Walker B; other site
657323001652	D-loop; other site
657323001653	H-loop/switch region; other site
657323001654	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
657323001655	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
657323001656	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657323001657	Walker A/P-loop; other site
657323001658	ATP binding site [chemical binding]; other site
657323001659	Q-loop/lid; other site
657323001660	ABC transporter signature motif; other site
657323001661	Walker B; other site
657323001662	D-loop; other site
657323001663	H-loop/switch region; other site
657323001664	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
657323001665	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
657323001666	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
657323001667	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
657323001668	homooctamer interface [polypeptide binding]; other site
657323001669	active site
657323001670	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
657323001671	catalytic center binding site [active]
657323001672	ATP binding site [chemical binding]; other site
657323001673	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
657323001674	dihydropteroate synthase; Region: DHPS; TIGR01496
657323001675	substrate binding pocket [chemical binding]; other site
657323001676	dimer interface [polypeptide binding]; other site
657323001677	inhibitor binding site; inhibition site
657323001678	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
657323001679	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
657323001680	homodecamer interface [polypeptide binding]; other site
657323001681	GTP cyclohydrolase I; Provisional; Region: PLN03044
657323001682	active site
657323001683	putative catalytic site residues [active]
657323001684	zinc binding site [ion binding]; other site
657323001685	GTP-CH-I/GFRP interaction surface; other site
657323001686	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
657323001687	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
657323001688	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
657323001689	active site
657323001690	RNA/DNA hybrid binding site [nucleotide binding]; other site
657323001691	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
657323001692	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
657323001693	active site
657323001694	HIGH motif; other site
657323001695	dimer interface [polypeptide binding]; other site
657323001696	KMSKS motif; other site
657323001697	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
657323001698	RNA binding surface [nucleotide binding]; other site
657323001699	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
657323001700	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
657323001701	motif 1; other site
657323001702	active site
657323001703	motif 2; other site
657323001704	motif 3; other site
657323001705	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
657323001706	DHHA1 domain; Region: DHHA1; pfam02272
657323001707	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
657323001708	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
657323001709	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
657323001710	PLD-like domain; Region: PLDc_2; pfam13091
657323001711	putative active site [active]
657323001712	catalytic site [active]
657323001713	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
657323001714	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
657323001715	putative active site [active]
657323001716	catalytic site [active]
657323001717	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
657323001718	putative homodimer interface [polypeptide binding]; other site
657323001719	putative homotetramer interface [polypeptide binding]; other site
657323001720	putative allosteric switch controlling residues; other site
657323001721	putative metal binding site [ion binding]; other site
657323001722	putative homodimer-homodimer interface [polypeptide binding]; other site
657323001723	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
657323001724	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
657323001725	metal-binding site [ion binding]
657323001726	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
657323001727	Soluble P-type ATPase [General function prediction only]; Region: COG4087
657323001728	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
657323001729	metal-binding site [ion binding]
657323001730	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
657323001731	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
657323001732	active site
657323001733	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657323001734	active site
657323001735	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
657323001736	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
657323001737	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323001738	motif II; other site
657323001739	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
657323001740	dimer interface [polypeptide binding]; other site
657323001741	substrate binding site [chemical binding]; other site
657323001742	ATP binding site [chemical binding]; other site
657323001743	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
657323001744	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
657323001745	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
657323001746	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
657323001747	active site
657323001748	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
657323001749	active site
657323001750	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
657323001751	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
657323001752	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
657323001753	putative active site [active]
657323001754	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323001755	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657323001756	dimerization interface [polypeptide binding]; other site
657323001757	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323001758	dimer interface [polypeptide binding]; other site
657323001759	phosphorylation site [posttranslational modification]
657323001760	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323001761	ATP binding site [chemical binding]; other site
657323001762	Mg2+ binding site [ion binding]; other site
657323001763	G-X-G motif; other site
657323001764	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323001765	Walker A/P-loop; other site
657323001766	ATP binding site [chemical binding]; other site
657323001767	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
657323001768	Peptidase family M28; Region: Peptidase_M28; pfam04389
657323001769	metal binding site [ion binding]; metal-binding site
657323001770	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
657323001771	Rubredoxin [Energy production and conversion]; Region: COG1773
657323001772	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
657323001773	iron binding site [ion binding]; other site
657323001774	Hemerythrin; Region: Hemerythrin; cd12107
657323001775	Fe binding site [ion binding]; other site
657323001776	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
657323001777	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
657323001778	catalytic triad [active]
657323001779	Protein of unknown function (DUF328); Region: DUF328; cl01143
657323001780	Rubrerythrin [Energy production and conversion]; Region: COG1592
657323001781	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
657323001782	iron binding site [ion binding]; other site
657323001783	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
657323001784	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018
657323001785	non-heme iron binding site [ion binding]; other site
657323001786	dimer interface [polypeptide binding]; other site
657323001787	Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880
657323001788	non-heme iron binding site [ion binding]; other site
657323001789	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
657323001790	Rubredoxin; Region: Rubredoxin; pfam00301
657323001791	iron binding site [ion binding]; other site
657323001792	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
657323001793	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
657323001794	NAD(P) binding site [chemical binding]; other site
657323001795	active site
657323001796	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
657323001797	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
657323001798	catalytic residues [active]
657323001799	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
657323001800	active site residue [active]
657323001801	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
657323001802	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
657323001803	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
657323001804	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
657323001805	active site residue [active]
657323001806	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
657323001807	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
657323001808	putative switch regulator; other site
657323001809	non-specific DNA interactions [nucleotide binding]; other site
657323001810	DNA binding site [nucleotide binding]
657323001811	sequence specific DNA binding site [nucleotide binding]; other site
657323001812	putative cAMP binding site [chemical binding]; other site
657323001813	phosphodiesterase; Provisional; Region: PRK12704
657323001814	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
657323001815	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
657323001816	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
657323001817	catalytic residues [active]
657323001818	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
657323001819	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
657323001820	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
657323001821	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
657323001822	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
657323001823	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
657323001824	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
657323001825	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
657323001826	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
657323001827	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
657323001828	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
657323001829	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
657323001830	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
657323001831	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
657323001832	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
657323001833	SdpI/YhfL protein family; Region: SdpI; pfam13630
657323001834	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
657323001835	Probable transposase; Region: OrfB_IS605; pfam01385
657323001836	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
657323001837	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323001838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323001839	active site
657323001840	phosphorylation site [posttranslational modification]
657323001841	intermolecular recognition site; other site
657323001842	dimerization interface [polypeptide binding]; other site
657323001843	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323001844	DNA binding site [nucleotide binding]
657323001845	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323001846	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323001847	dimer interface [polypeptide binding]; other site
657323001848	phosphorylation site [posttranslational modification]
657323001849	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323001850	ATP binding site [chemical binding]; other site
657323001851	Mg2+ binding site [ion binding]; other site
657323001852	G-X-G motif; other site
657323001853	Domain of unknown function (DUF4209); Region: DUF4209; pfam13910
657323001854	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
657323001855	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
657323001856	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657323001857	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323001858	non-specific DNA binding site [nucleotide binding]; other site
657323001859	salt bridge; other site
657323001860	sequence-specific DNA binding site [nucleotide binding]; other site
657323001861	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
657323001862	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323001863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323001864	active site
657323001865	phosphorylation site [posttranslational modification]
657323001866	intermolecular recognition site; other site
657323001867	dimerization interface [polypeptide binding]; other site
657323001868	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323001869	DNA binding site [nucleotide binding]
657323001870	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323001871	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323001872	dimer interface [polypeptide binding]; other site
657323001873	phosphorylation site [posttranslational modification]
657323001874	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323001875	ATP binding site [chemical binding]; other site
657323001876	Mg2+ binding site [ion binding]; other site
657323001877	G-X-G motif; other site
657323001878	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657323001879	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657323001880	Walker A/P-loop; other site
657323001881	ATP binding site [chemical binding]; other site
657323001882	Q-loop/lid; other site
657323001883	ABC transporter signature motif; other site
657323001884	Walker B; other site
657323001885	D-loop; other site
657323001886	H-loop/switch region; other site
657323001887	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
657323001888	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657323001889	FtsX-like permease family; Region: FtsX; pfam02687
657323001890	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657323001891	FtsX-like permease family; Region: FtsX; pfam02687
657323001892	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
657323001893	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657323001894	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
657323001895	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
657323001896	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
657323001897	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
657323001898	Mg binding site [ion binding]; other site
657323001899	nucleotide binding site [chemical binding]; other site
657323001900	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
657323001901	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
657323001902	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657323001903	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323001904	non-specific DNA binding site [nucleotide binding]; other site
657323001905	salt bridge; other site
657323001906	sequence-specific DNA binding site [nucleotide binding]; other site
657323001907	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
657323001908	putative active site [active]
657323001909	Protein of unknown function (DUF3609); Region: DUF3609; pfam12259
657323001910	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323001911	AAA domain; Region: AAA_21; pfam13304
657323001912	Walker A/P-loop; other site
657323001913	ATP binding site [chemical binding]; other site
657323001914	AAA domain; Region: AAA_21; pfam13304
657323001915	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
657323001916	DNA-binding site [nucleotide binding]; DNA binding site
657323001917	RNA-binding motif; other site
657323001918	ERF superfamily; Region: ERF; pfam04404
657323001919	DNA primase, catalytic core; Region: dnaG; TIGR01391
657323001920	Cna protein B-type domain; Region: Cna_B; pfam05738
657323001921	Cna protein B-type domain; Region: Cna_B; pfam05738
657323001922	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
657323001923	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323001924	Leucine rich repeat; Region: LRR_8; pfam13855
657323001925	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
657323001926	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
657323001927	Walker A/P-loop; other site
657323001928	ATP binding site [chemical binding]; other site
657323001929	Q-loop/lid; other site
657323001930	ABC transporter signature motif; other site
657323001931	Walker B; other site
657323001932	D-loop; other site
657323001933	H-loop/switch region; other site
657323001934	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323001935	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
657323001936	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323001937	ABC transporter signature motif; other site
657323001938	Walker B; other site
657323001939	D-loop; other site
657323001940	H-loop/switch region; other site
657323001941	MoxR-like ATPases [General function prediction only]; Region: COG0714
657323001942	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323001943	Walker A motif; other site
657323001944	ATP binding site [chemical binding]; other site
657323001945	Walker B motif; other site
657323001946	arginine finger; other site
657323001947	Protein of unknown function DUF58; Region: DUF58; pfam01882
657323001948	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
657323001949	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
657323001950	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
657323001951	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
657323001952	Trp docking motif [polypeptide binding]; other site
657323001953	active site
657323001954	FOG: WD40-like repeat [Function unknown]; Region: COG1520
657323001955	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
657323001956	TIR domain; Region: TIR_2; pfam13676
657323001957	Penicillinase repressor; Region: Pencillinase_R; pfam03965
657323001958	Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250
657323001959	Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060
657323001960	Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250
657323001961	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
657323001962	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
657323001963	dimer interface [polypeptide binding]; other site
657323001964	ssDNA binding site [nucleotide binding]; other site
657323001965	tetramer (dimer of dimers) interface [polypeptide binding]; other site
657323001966	AAA domain; Region: AAA_30; pfam13604
657323001967	Family description; Region: UvrD_C_2; pfam13538
657323001968	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
657323001969	metal ion-dependent adhesion site (MIDAS); other site
657323001970	Protein of unknown function (DUF1168); Region: DUF1168; pfam06658
657323001971	Winged helix-turn helix; Region: HTH_29; pfam13551
657323001972	Domain of unknown function (DUF4313); Region: DUF4313; pfam14190
657323001973	PcfK-like protein; Region: PcfK; pfam14058
657323001974	PcfK-like protein; Region: PcfK; pfam14058
657323001975	PcfJ-like protein; Region: PcfJ; pfam14284
657323001976	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323001977	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
657323001978	active site
657323001979	Int/Topo IB signature motif; other site
657323001980	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
657323001981	MutS domain I; Region: MutS_I; pfam01624
657323001982	MutS domain II; Region: MutS_II; pfam05188
657323001983	MutS domain III; Region: MutS_III; pfam05192
657323001984	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
657323001985	Walker A/P-loop; other site
657323001986	ATP binding site [chemical binding]; other site
657323001987	Q-loop/lid; other site
657323001988	ABC transporter signature motif; other site
657323001989	Walker B; other site
657323001990	D-loop; other site
657323001991	H-loop/switch region; other site
657323001992	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
657323001993	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
657323001994	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
657323001995	Aluminium resistance protein; Region: Alum_res; pfam06838
657323001996	flavoprotein, HI0933 family; Region: TIGR00275
657323001997	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
657323001998	FAD dependent oxidoreductase; Region: DAO; pfam01266
657323001999	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
657323002000	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
657323002001	hypothetical protein; Reviewed; Region: PRK00024
657323002002	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
657323002003	MPN+ (JAMM) motif; other site
657323002004	Zinc-binding site [ion binding]; other site
657323002005	rod shape-determining protein MreB; Provisional; Region: PRK13927
657323002006	MreB and similar proteins; Region: MreB_like; cd10225
657323002007	nucleotide binding site [chemical binding]; other site
657323002008	Mg binding site [ion binding]; other site
657323002009	putative protofilament interaction site [polypeptide binding]; other site
657323002010	RodZ interaction site [polypeptide binding]; other site
657323002011	rod shape-determining protein MreC; Provisional; Region: PRK13922
657323002012	rod shape-determining protein MreC; Region: MreC; pfam04085
657323002013	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
657323002014	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
657323002015	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
657323002016	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
657323002017	Switch I; other site
657323002018	Switch II; other site
657323002019	Septum formation topological specificity factor MinE; Region: MinE; cl00538
657323002020	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
657323002021	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
657323002022	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
657323002023	HD domain; Region: HD_3; cl17350
657323002024	DNA polymerase IV; Reviewed; Region: PRK03103
657323002025	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
657323002026	active site
657323002027	DNA binding site [nucleotide binding]
657323002028	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
657323002029	Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749
657323002030	Lyase; Region: Lyase_1; pfam00206
657323002031	Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353
657323002032	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
657323002033	active site
657323002034	catalytic site [active]
657323002035	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
657323002036	dimer interface [polypeptide binding]; other site
657323002037	Citrate synthase; Region: Citrate_synt; pfam00285
657323002038	active site
657323002039	citrylCoA binding site [chemical binding]; other site
657323002040	oxalacetate/citrate binding site [chemical binding]; other site
657323002041	coenzyme A binding site [chemical binding]; other site
657323002042	catalytic triad [active]
657323002043	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323002044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323002045	active site
657323002046	phosphorylation site [posttranslational modification]
657323002047	intermolecular recognition site; other site
657323002048	dimerization interface [polypeptide binding]; other site
657323002049	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323002050	DNA binding site [nucleotide binding]
657323002051	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323002052	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657323002053	dimerization interface [polypeptide binding]; other site
657323002054	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323002055	dimer interface [polypeptide binding]; other site
657323002056	phosphorylation site [posttranslational modification]
657323002057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323002058	ATP binding site [chemical binding]; other site
657323002059	Mg2+ binding site [ion binding]; other site
657323002060	G-X-G motif; other site
657323002061	EDD domain protein, DegV family; Region: DegV; TIGR00762
657323002062	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
657323002063	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
657323002064	signature motif; other site
657323002065	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
657323002066	putative metal binding residues [ion binding]; other site
657323002067	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
657323002068	active site
657323002069	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
657323002070	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
657323002071	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323002072	active site
657323002073	Int/Topo IB signature motif; other site
657323002074	DNA binding site [nucleotide binding]
657323002075	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
657323002076	putative active site [active]
657323002077	dimerization interface [polypeptide binding]; other site
657323002078	putative tRNAtyr binding site [nucleotide binding]; other site
657323002079	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
657323002080	Domain of unknown function DUF20; Region: UPF0118; pfam01594
657323002081	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
657323002082	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
657323002083	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
657323002084	RNA binding surface [nucleotide binding]; other site
657323002085	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
657323002086	active site
657323002087	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
657323002088	lipoprotein signal peptidase; Provisional; Region: PRK14787
657323002089	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
657323002090	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
657323002091	Protein of unknown function (DUF552); Region: DUF552; pfam04472
657323002092	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
657323002093	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
657323002094	catalytic residue [active]
657323002095	LexA repressor; Validated; Region: PRK00215
657323002096	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
657323002097	putative DNA binding site [nucleotide binding]; other site
657323002098	putative Zn2+ binding site [ion binding]; other site
657323002099	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
657323002100	Catalytic site [active]
657323002101	Oligomerisation domain; Region: Oligomerisation; pfam02410
657323002102	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657323002103	Zn2+ binding site [ion binding]; other site
657323002104	Mg2+ binding site [ion binding]; other site
657323002105	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
657323002106	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
657323002107	active site
657323002108	(T/H)XGH motif; other site
657323002109	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
657323002110	GTPase CgtA; Reviewed; Region: obgE; PRK12297
657323002111	GTP1/OBG; Region: GTP1_OBG; pfam01018
657323002112	Obg GTPase; Region: Obg; cd01898
657323002113	G1 box; other site
657323002114	GTP/Mg2+ binding site [chemical binding]; other site
657323002115	Switch I region; other site
657323002116	G2 box; other site
657323002117	G3 box; other site
657323002118	Switch II region; other site
657323002119	G4 box; other site
657323002120	G5 box; other site
657323002121	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
657323002122	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
657323002123	Protein of unknown function (DUF464); Region: DUF464; pfam04327
657323002124	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
657323002125	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
657323002126	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
657323002127	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323002128	FeS/SAM binding site; other site
657323002129	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
657323002130	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
657323002131	putative active site [active]
657323002132	nucleotide binding site [chemical binding]; other site
657323002133	nudix motif; other site
657323002134	putative metal binding site [ion binding]; other site
657323002135	Membrane transport protein; Region: Mem_trans; cl09117
657323002136	PIF1-like helicase; Region: PIF1; pfam05970
657323002137	A new structural DNA glycosylase; Region: AlkD_like; cd06561
657323002138	active site
657323002139	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
657323002140	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095
657323002141	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
657323002142	active site
657323002143	dimer interface [polypeptide binding]; other site
657323002144	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
657323002145	dimer interface [polypeptide binding]; other site
657323002146	active site
657323002147	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323002148	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
657323002149	active site
657323002150	motif I; other site
657323002151	motif II; other site
657323002152	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
657323002153	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
657323002154	Competence-damaged protein; Region: CinA; pfam02464
657323002155	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
657323002156	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
657323002157	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
657323002158	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
657323002159	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323002160	FeS/SAM binding site; other site
657323002161	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
657323002162	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
657323002163	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
657323002164	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
657323002165	catalytic site [active]
657323002166	G-X2-G-X-G-K; other site
657323002167	hypothetical protein; Provisional; Region: PRK04323
657323002168	hypothetical protein; Provisional; Region: PRK11820
657323002169	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
657323002170	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
657323002171	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
657323002172	Domain of unknown function (DUF814); Region: DUF814; pfam05670
657323002173	dimerization interface [polypeptide binding]; other site
657323002174	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
657323002175	putative active cleft [active]
657323002176	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
657323002177	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
657323002178	Cl- selectivity filter; other site
657323002179	Cl- binding residues [ion binding]; other site
657323002180	pore gating glutamate residue; other site
657323002181	dimer interface [polypeptide binding]; other site
657323002182	Uncharacterized conserved protein [Function unknown]; Region: COG0398
657323002183	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
657323002184	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
657323002185	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
657323002186	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323002187	FeS/SAM binding site; other site
657323002188	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
657323002189	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
657323002190	HIGH motif; other site
657323002191	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
657323002192	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657323002193	active site
657323002194	KMSKS motif; other site
657323002195	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
657323002196	tRNA binding surface [nucleotide binding]; other site
657323002197	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
657323002198	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
657323002199	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
657323002200	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
657323002201	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
657323002202	trimer interface [polypeptide binding]; other site
657323002203	active site
657323002204	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
657323002205	catalytic site [active]
657323002206	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657323002207	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657323002208	ligand binding site [chemical binding]; other site
657323002209	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657323002210	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323002211	DNA binding site [nucleotide binding]
657323002212	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657323002213	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
657323002214	elongation factor G; Reviewed; Region: PRK12740
657323002215	G1 box; other site
657323002216	putative GEF interaction site [polypeptide binding]; other site
657323002217	GTP/Mg2+ binding site [chemical binding]; other site
657323002218	Switch I region; other site
657323002219	G2 box; other site
657323002220	G3 box; other site
657323002221	Switch II region; other site
657323002222	G4 box; other site
657323002223	G5 box; other site
657323002224	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
657323002225	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
657323002226	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
657323002227	putative hydrolase; Validated; Region: PRK09248
657323002228	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
657323002229	active site
657323002230	prephenate dehydrogenase; Validated; Region: PRK06545
657323002231	prephenate dehydrogenase; Validated; Region: PRK08507
657323002232	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
657323002233	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
657323002234	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
657323002235	hinge; other site
657323002236	active site
657323002237	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
657323002238	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
657323002239	putative ligand binding site [chemical binding]; other site
657323002240	putative NAD binding site [chemical binding]; other site
657323002241	catalytic site [active]
657323002242	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
657323002243	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
657323002244	AP (apurinic/apyrimidinic) site pocket; other site
657323002245	DNA interaction; other site
657323002246	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
657323002247	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
657323002248	putative active site [active]
657323002249	putative metal binding site [ion binding]; other site
657323002250	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
657323002251	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
657323002252	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
657323002253	PRC-barrel domain; Region: PRC; pfam05239
657323002254	RimM N-terminal domain; Region: RimM; pfam01782
657323002255	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
657323002256	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
657323002257	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
657323002258	signal recognition particle protein; Provisional; Region: PRK10867
657323002259	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
657323002260	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
657323002261	P loop; other site
657323002262	GTP binding site [chemical binding]; other site
657323002263	Signal peptide binding domain; Region: SRP_SPB; pfam02978
657323002264	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
657323002265	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657323002266	DNA binding residues [nucleotide binding]
657323002267	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
657323002268	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
657323002269	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
657323002270	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
657323002271	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
657323002272	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
657323002273	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
657323002274	PhoU domain; Region: PhoU; pfam01895
657323002275	PhoU domain; Region: PhoU; pfam01895
657323002276	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
657323002277	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
657323002278	cofactor binding site; other site
657323002279	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
657323002280	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
657323002281	glutaminase active site [active]
657323002282	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
657323002283	dimer interface [polypeptide binding]; other site
657323002284	active site
657323002285	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
657323002286	dimer interface [polypeptide binding]; other site
657323002287	active site
657323002288	threonine dehydratase; Provisional; Region: PRK08198
657323002289	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
657323002290	tetramer interface [polypeptide binding]; other site
657323002291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323002292	catalytic residue [active]
657323002293	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
657323002294	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
657323002295	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
657323002296	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
657323002297	P loop; other site
657323002298	GTP binding site [chemical binding]; other site
657323002299	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
657323002300	ABC transporter signature motif; other site
657323002301	Walker B; other site
657323002302	D-loop; other site
657323002303	H-loop/switch region; other site
657323002304	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
657323002305	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
657323002306	Walker A/P-loop; other site
657323002307	ATP binding site [chemical binding]; other site
657323002308	Q-loop/lid; other site
657323002309	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
657323002310	ribonuclease III; Reviewed; Region: rnc; PRK00102
657323002311	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
657323002312	dimerization interface [polypeptide binding]; other site
657323002313	active site
657323002314	metal binding site [ion binding]; metal-binding site
657323002315	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
657323002316	dsRNA binding site [nucleotide binding]; other site
657323002317	acyl carrier protein; Provisional; Region: acpP; PRK00982
657323002318	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
657323002319	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
657323002320	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657323002321	ABC transporter; Region: ABC_tran_2; pfam12848
657323002322	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657323002323	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323002324	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657323002325	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657323002326	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
657323002327	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
657323002328	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
657323002329	propionate/acetate kinase; Provisional; Region: PRK12379
657323002330	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
657323002331	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
657323002332	hypothetical protein; Provisional; Region: PRK13670
657323002333	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
657323002334	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657323002335	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323002336	homodimer interface [polypeptide binding]; other site
657323002337	catalytic residue [active]
657323002338	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
657323002339	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323002340	Walker A/P-loop; other site
657323002341	ATP binding site [chemical binding]; other site
657323002342	Q-loop/lid; other site
657323002343	ABC transporter signature motif; other site
657323002344	Walker B; other site
657323002345	D-loop; other site
657323002346	H-loop/switch region; other site
657323002347	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
657323002348	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
657323002349	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
657323002350	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
657323002351	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
657323002352	CoA-binding site [chemical binding]; other site
657323002353	ATP-binding [chemical binding]; other site
657323002354	Putative zinc-finger; Region: zf-HC2; pfam13490
657323002355	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
657323002356	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
657323002357	FtsH Extracellular; Region: FtsH_ext; pfam06480
657323002358	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
657323002359	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
657323002360	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323002361	Walker A motif; other site
657323002362	ATP binding site [chemical binding]; other site
657323002363	Walker B motif; other site
657323002364	arginine finger; other site
657323002365	Peptidase family M41; Region: Peptidase_M41; pfam01434
657323002366	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
657323002367	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323002368	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
657323002369	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
657323002370	active site
657323002371	domain interfaces; other site
657323002372	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
657323002373	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
657323002374	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
657323002375	oligomer interface [polypeptide binding]; other site
657323002376	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
657323002377	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
657323002378	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
657323002379	inhibitor-cofactor binding pocket; inhibition site
657323002380	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323002381	catalytic residue [active]
657323002382	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
657323002383	dimer interface [polypeptide binding]; other site
657323002384	active site
657323002385	Schiff base residues; other site
657323002386	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
657323002387	active site
657323002388	SAM binding site [chemical binding]; other site
657323002389	homodimer interface [polypeptide binding]; other site
657323002390	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
657323002391	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
657323002392	active site
657323002393	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
657323002394	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
657323002395	active site
657323002396	domain interfaces; other site
657323002397	Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379
657323002398	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
657323002399	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
657323002400	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
657323002401	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
657323002402	tRNA; other site
657323002403	putative tRNA binding site [nucleotide binding]; other site
657323002404	putative NADP binding site [chemical binding]; other site
657323002405	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
657323002406	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
657323002407	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
657323002408	active site
657323002409	C-terminal domain interface [polypeptide binding]; other site
657323002410	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
657323002411	active site
657323002412	N-terminal domain interface [polypeptide binding]; other site
657323002413	isocitrate dehydrogenase; Validated; Region: PRK08299
657323002414	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
657323002415	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
657323002416	active site
657323002417	catalytic triad [active]
657323002418	DHHW protein; Region: DHHW; pfam14286
657323002419	DHHW protein; Region: DHHW; pfam14286
657323002420	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
657323002421	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
657323002422	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
657323002423	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
657323002424	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
657323002425	catalytic loop [active]
657323002426	iron binding site [ion binding]; other site
657323002427	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
657323002428	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
657323002429	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657323002430	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
657323002431	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503
657323002432	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
657323002433	dimer interface [polypeptide binding]; other site
657323002434	[2Fe-2S] cluster binding site [ion binding]; other site
657323002435	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
657323002436	SLBB domain; Region: SLBB; pfam10531
657323002437	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
657323002438	4Fe-4S binding domain; Region: Fer4; pfam00037
657323002439	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
657323002440	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
657323002441	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
657323002442	putative dimer interface [polypeptide binding]; other site
657323002443	[2Fe-2S] cluster binding site [ion binding]; other site
657323002444	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
657323002445	4Fe-4S binding domain; Region: Fer4_6; pfam12837
657323002446	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
657323002447	4Fe-4S binding domain; Region: Fer4; pfam00037
657323002448	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
657323002449	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
657323002450	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
657323002451	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
657323002452	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
657323002453	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Region: THF_DHG_CYH_C; pfam02882
657323002454	NAD(P) binding pocket [chemical binding]; other site
657323002455	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
657323002456	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
657323002457	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
657323002458	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
657323002459	Potassium binding sites [ion binding]; other site
657323002460	Cesium cation binding sites [ion binding]; other site
657323002461	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
657323002462	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
657323002463	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
657323002464	catalytic loop [active]
657323002465	iron binding site [ion binding]; other site
657323002466	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
657323002467	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
657323002468	substrate binding pocket [chemical binding]; other site
657323002469	dimer interface [polypeptide binding]; other site
657323002470	inhibitor binding site; inhibition site
657323002471	acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165
657323002472	Putative Fe-S cluster; Region: FeS; cl17515
657323002473	acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452
657323002474	acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452
657323002475	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
657323002476	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
657323002477	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657323002478	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657323002479	Prismane/CO dehydrogenase family; Region: Prismane; pfam03063
657323002480	metal cluster binding site [ion binding]; other site
657323002481	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657323002482	ACS interaction site; other site
657323002483	CODH interaction site; other site
657323002484	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
657323002485	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657323002486	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
657323002487	FAD binding site [chemical binding]; other site
657323002488	Predicted RNA-binding protein; Region: RNA_bind_2; cl00662
657323002489	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
657323002490	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
657323002491	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
657323002492	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
657323002493	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
657323002494	GTP-binding protein Der; Reviewed; Region: PRK00093
657323002495	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
657323002496	G1 box; other site
657323002497	GTP/Mg2+ binding site [chemical binding]; other site
657323002498	Switch I region; other site
657323002499	G2 box; other site
657323002500	Switch II region; other site
657323002501	G3 box; other site
657323002502	G4 box; other site
657323002503	G5 box; other site
657323002504	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
657323002505	G1 box; other site
657323002506	GTP/Mg2+ binding site [chemical binding]; other site
657323002507	Switch I region; other site
657323002508	G2 box; other site
657323002509	G3 box; other site
657323002510	Switch II region; other site
657323002511	G4 box; other site
657323002512	G5 box; other site
657323002513	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
657323002514	PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992
657323002515	Protein of unknown function (DUF512); Region: DUF512; pfam04459
657323002516	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
657323002517	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
657323002518	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657323002519	active site
657323002520	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
657323002521	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
657323002522	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
657323002523	RNA/DNA hybrid binding site [nucleotide binding]; other site
657323002524	active site
657323002525	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
657323002526	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
657323002527	GTP/Mg2+ binding site [chemical binding]; other site
657323002528	G4 box; other site
657323002529	G5 box; other site
657323002530	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
657323002531	G1 box; other site
657323002532	G1 box; other site
657323002533	GTP/Mg2+ binding site [chemical binding]; other site
657323002534	Switch I region; other site
657323002535	G2 box; other site
657323002536	G2 box; other site
657323002537	G3 box; other site
657323002538	G3 box; other site
657323002539	Switch II region; other site
657323002540	Switch II region; other site
657323002541	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
657323002542	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
657323002543	Catalytic site [active]
657323002544	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
657323002545	methionine aminopeptidase; Provisional; Region: PRK12318
657323002546	SEC-C motif; Region: SEC-C; pfam02810
657323002547	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
657323002548	active site
657323002549	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
657323002550	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
657323002551	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
657323002552	5S rRNA interface [nucleotide binding]; other site
657323002553	CTC domain interface [polypeptide binding]; other site
657323002554	L16 interface [polypeptide binding]; other site
657323002555	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
657323002556	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
657323002557	Walker A/P-loop; other site
657323002558	ATP binding site [chemical binding]; other site
657323002559	Q-loop/lid; other site
657323002560	ABC transporter signature motif; other site
657323002561	Walker B; other site
657323002562	D-loop; other site
657323002563	H-loop/switch region; other site
657323002564	TOBE domain; Region: TOBE_2; pfam08402
657323002565	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
657323002566	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323002567	putative PBP binding loops; other site
657323002568	ABC-ATPase subunit interface; other site
657323002569	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657323002570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323002571	dimer interface [polypeptide binding]; other site
657323002572	conserved gate region; other site
657323002573	putative PBP binding loops; other site
657323002574	ABC-ATPase subunit interface; other site
657323002575	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323002576	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
657323002577	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657323002578	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
657323002579	active site
657323002580	Acyltransferase family; Region: Acyl_transf_3; pfam01757
657323002581	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
657323002582	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657323002583	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964
657323002584	active site
657323002585	nucleotide binding site [chemical binding]; other site
657323002586	HIGH motif; other site
657323002587	KMSKS motif; other site
657323002588	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
657323002589	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
657323002590	LicD family; Region: LicD; pfam04991
657323002591	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
657323002592	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
657323002593	PYR/PP interface [polypeptide binding]; other site
657323002594	dimer interface [polypeptide binding]; other site
657323002595	TPP binding site [chemical binding]; other site
657323002596	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
657323002597	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
657323002598	TPP-binding site [chemical binding]; other site
657323002599	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
657323002600	classical (c) SDRs; Region: SDR_c; cd05233
657323002601	NAD(P) binding site [chemical binding]; other site
657323002602	active site
657323002603	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
657323002604	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
657323002605	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
657323002606	putative homodimer interface [polypeptide binding]; other site
657323002607	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
657323002608	heterodimer interface [polypeptide binding]; other site
657323002609	homodimer interface [polypeptide binding]; other site
657323002610	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
657323002611	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
657323002612	23S rRNA interface [nucleotide binding]; other site
657323002613	L7/L12 interface [polypeptide binding]; other site
657323002614	putative thiostrepton binding site; other site
657323002615	L25 interface [polypeptide binding]; other site
657323002616	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
657323002617	mRNA/rRNA interface [nucleotide binding]; other site
657323002618	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
657323002619	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657323002620	DNA-binding site [nucleotide binding]; DNA binding site
657323002621	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
657323002622	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
657323002623	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
657323002624	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
657323002625	dimer interface [polypeptide binding]; other site
657323002626	active site
657323002627	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
657323002628	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
657323002629	substrate binding site [chemical binding]; other site
657323002630	ATP binding site [chemical binding]; other site
657323002631	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
657323002632	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
657323002633	substrate binding pocket [chemical binding]; other site
657323002634	membrane-bound complex binding site; other site
657323002635	hinge residues; other site
657323002636	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
657323002637	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323002638	FeS/SAM binding site; other site
657323002639	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
657323002640	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
657323002641	putative acyl-acceptor binding pocket; other site
657323002642	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
657323002643	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
657323002644	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
657323002645	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
657323002646	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
657323002647	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
657323002648	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
657323002649	Transcriptional regulators [Transcription]; Region: GntR; COG1802
657323002650	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657323002651	DNA-binding site [nucleotide binding]; DNA binding site
657323002652	FCD domain; Region: FCD; cl11656
657323002653	FCD domain; Region: FCD; cl11656
657323002654	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
657323002655	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
657323002656	glutamate racemase; Provisional; Region: PRK00865
657323002657	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
657323002658	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
657323002659	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
657323002660	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
657323002661	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
657323002662	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
657323002663	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
657323002664	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
657323002665	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
657323002666	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
657323002667	putative active site [active]
657323002668	putative metal binding site [ion binding]; other site
657323002669	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
657323002670	Transposase IS200 like; Region: Y1_Tnp; pfam01797
657323002671	Probable transposase; Region: OrfB_IS605; pfam01385
657323002672	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
657323002673	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
657323002674	active site
657323002675	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
657323002676	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
657323002677	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
657323002678	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657323002679	dimerization interface [polypeptide binding]; other site
657323002680	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657323002681	ligand binding site [chemical binding]; other site
657323002682	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
657323002683	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
657323002684	active pocket/dimerization site; other site
657323002685	active site
657323002686	phosphorylation site [posttranslational modification]
657323002687	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
657323002688	active site
657323002689	phosphorylation site [posttranslational modification]
657323002690	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
657323002691	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
657323002692	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
657323002693	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
657323002694	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
657323002695	Ca binding site [ion binding]; other site
657323002696	active site
657323002697	catalytic site [active]
657323002698	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
657323002699	Uncharacterized conserved protein [Function unknown]; Region: COG1284
657323002700	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
657323002701	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
657323002702	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
657323002703	NlpC/P60 family; Region: NLPC_P60; pfam00877
657323002704	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
657323002705	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
657323002706	Peptidase family M28; Region: Peptidase_M28; pfam04389
657323002707	metal binding site [ion binding]; metal-binding site
657323002708	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
657323002709	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
657323002710	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
657323002711	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
657323002712	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
657323002713	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
657323002714	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
657323002715	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657323002716	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323002717	DNA binding site [nucleotide binding]
657323002718	domain linker motif; other site
657323002719	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657323002720	ligand binding site [chemical binding]; other site
657323002721	dimerization interface [polypeptide binding]; other site
657323002722	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657323002723	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323002724	DNA binding site [nucleotide binding]
657323002725	domain linker motif; other site
657323002726	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657323002727	dimerization interface [polypeptide binding]; other site
657323002728	ligand binding site [chemical binding]; other site
657323002729	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
657323002730	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
657323002731	active site
657323002732	trimer interface [polypeptide binding]; other site
657323002733	allosteric site; other site
657323002734	active site lid [active]
657323002735	hexamer (dimer of trimers) interface [polypeptide binding]; other site
657323002736	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657323002737	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323002738	ATP synthase subunit D; Region: ATP-synt_D; pfam01813
657323002739	V-type ATP synthase subunit B; Provisional; Region: PRK04196
657323002740	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
657323002741	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
657323002742	Walker A motif homologous position; other site
657323002743	Walker B motif; other site
657323002744	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
657323002745	V-type ATP synthase subunit A; Provisional; Region: PRK04192
657323002746	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
657323002747	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
657323002748	Walker A motif/ATP binding site; other site
657323002749	Walker B motif; other site
657323002750	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
657323002751	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
657323002752	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990
657323002753	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
657323002754	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
657323002755	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323002756	S-adenosylmethionine binding site [chemical binding]; other site
657323002757	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
657323002758	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
657323002759	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323002760	non-specific DNA binding site [nucleotide binding]; other site
657323002761	salt bridge; other site
657323002762	sequence-specific DNA binding site [nucleotide binding]; other site
657323002763	Helix-turn-helix domain; Region: HTH_17; cl17695
657323002764	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
657323002765	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323002766	AAA domain; Region: AAA_23; pfam13476
657323002767	Walker A/P-loop; other site
657323002768	ATP binding site [chemical binding]; other site
657323002769	RecT family; Region: RecT; cl04285
657323002770	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
657323002771	Tumour-associated protein; Region: Membralin; pfam09746
657323002772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323002773	Walker A motif; other site
657323002774	ATP binding site [chemical binding]; other site
657323002775	Walker B motif; other site
657323002776	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
657323002777	Ligand Binding Site [chemical binding]; other site
657323002778	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
657323002779	DNA methylase; Region: N6_N4_Mtase; cl17433
657323002780	DNA methylase; Region: N6_N4_Mtase; pfam01555
657323002781	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
657323002782	RNA/DNA hybrid binding site [nucleotide binding]; other site
657323002783	active site
657323002784	Recombination protein U; Region: RecU; cl01314
657323002785	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
657323002786	ParB-like nuclease domain; Region: ParB; smart00470
657323002787	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
657323002788	DNA methylase; Region: N6_N4_Mtase; pfam01555
657323002789	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
657323002790	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
657323002791	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
657323002792	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
657323002793	Phage XkdN-like protein; Region: XkdN; pfam08890
657323002794	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
657323002795	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
657323002796	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
657323002797	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
657323002798	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
657323002799	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
657323002800	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
657323002801	putative active site [active]
657323002802	putative NTP binding site [chemical binding]; other site
657323002803	putative nucleic acid binding site [nucleotide binding]; other site
657323002804	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
657323002805	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
657323002806	amidase catalytic site [active]
657323002807	Zn binding residues [ion binding]; other site
657323002808	substrate binding site [chemical binding]; other site
657323002809	Bacterial SH3 domain; Region: SH3_3; pfam08239
657323002810	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
657323002811	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
657323002812	HsdM N-terminal domain; Region: HsdM_N; pfam12161
657323002813	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
657323002814	Methyltransferase domain; Region: Methyltransf_26; pfam13659
657323002815	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
657323002816	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
657323002817	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
657323002818	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
657323002819	hypothetical protein; Provisional; Region: PRK06062
657323002820	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
657323002821	inhibitor-cofactor binding pocket; inhibition site
657323002822	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323002823	catalytic residue [active]
657323002824	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
657323002825	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
657323002826	active site
657323002827	NAD binding site [chemical binding]; other site
657323002828	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
657323002829	metal binding site [ion binding]; metal-binding site
657323002830	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
657323002831	Nitrogen regulatory protein P-II; Region: P-II; smart00938
657323002832	Amino acid permease; Region: AA_permease; pfam00324
657323002833	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
657323002834	Domain of unknown function DUF20; Region: UPF0118; pfam01594
657323002835	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
657323002836	Predicted membrane protein [Function unknown]; Region: COG2510
657323002837	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
657323002838	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
657323002839	active site
657323002840	metal binding site [ion binding]; metal-binding site
657323002841	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
657323002842	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
657323002843	MarR family; Region: MarR_2; pfam12802
657323002844	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323002845	S-adenosylmethionine binding site [chemical binding]; other site
657323002846	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
657323002847	FMN binding site [chemical binding]; other site
657323002848	dimer interface [polypeptide binding]; other site
657323002849	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
657323002850	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
657323002851	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
657323002852	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
657323002853	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
657323002854	DctM-like transporters; Region: DctM; pfam06808
657323002855	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
657323002856	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
657323002857	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
657323002858	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
657323002859	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
657323002860	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
657323002861	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657323002862	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
657323002863	Domain of unknown function, E. rectale Gene description (DUF3878); Region: DUF3878; pfam12994
657323002864	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
657323002865	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
657323002866	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
657323002867	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
657323002868	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
657323002869	putative active site [active]
657323002870	catalytic residue [active]
657323002871	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
657323002872	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323002873	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
657323002874	active site
657323002875	motif I; other site
657323002876	motif II; other site
657323002877	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323002878	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
657323002879	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657323002880	active site
657323002881	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
657323002882	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
657323002883	putative dimer interface [polypeptide binding]; other site
657323002884	Melibiase; Region: Melibiase; pfam02065
657323002885	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657323002886	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323002887	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323002888	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323002889	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
657323002890	catalytic tetrad [active]
657323002891	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
657323002892	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
657323002893	active site
657323002894	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
657323002895	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657323002896	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
657323002897	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
657323002898	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
657323002899	substrate binding site [polypeptide binding]; other site
657323002900	dimer interface [polypeptide binding]; other site
657323002901	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
657323002902	Src Homology 3 domain superfamily; Region: SH3; cl17036
657323002903	peptide ligand binding site [polypeptide binding]; other site
657323002904	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323002905	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323002906	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657323002907	dimerization interface [polypeptide binding]; other site
657323002908	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
657323002909	FMN binding site [chemical binding]; other site
657323002910	dimer interface [polypeptide binding]; other site
657323002911	Acylphosphatase; Region: Acylphosphatase; pfam00708
657323002912	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
657323002913	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
657323002914	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
657323002915	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
657323002916	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
657323002917	Rubredoxin [Energy production and conversion]; Region: COG1773
657323002918	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350
657323002919	iron binding site [ion binding]; other site
657323002920	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
657323002921	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
657323002922	ligand binding site [chemical binding]; other site
657323002923	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
657323002924	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
657323002925	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
657323002926	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
657323002927	Predicted membrane protein [Function unknown]; Region: COG3326
657323002928	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
657323002929	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
657323002930	dimer interface [polypeptide binding]; other site
657323002931	active site
657323002932	CoA binding pocket [chemical binding]; other site
657323002933	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
657323002934	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
657323002935	FMN binding site [chemical binding]; other site
657323002936	substrate binding site [chemical binding]; other site
657323002937	putative catalytic residue [active]
657323002938	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
657323002939	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
657323002940	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
657323002941	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
657323002942	NAD(P) binding site [chemical binding]; other site
657323002943	homotetramer interface [polypeptide binding]; other site
657323002944	homodimer interface [polypeptide binding]; other site
657323002945	active site
657323002946	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
657323002947	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
657323002948	dimer interface [polypeptide binding]; other site
657323002949	active site
657323002950	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
657323002951	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
657323002952	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
657323002953	carboxyltransferase (CT) interaction site; other site
657323002954	biotinylation site [posttranslational modification]; other site
657323002955	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
657323002956	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
657323002957	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
657323002958	ATP-grasp domain; Region: ATP-grasp_4; cl17255
657323002959	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
657323002960	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
657323002961	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
657323002962	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
657323002963	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
657323002964	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
657323002965	HD domain; Region: HD_4; pfam13328
657323002966	Helix-turn-helix domain; Region: HTH_18; pfam12833
657323002967	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323002968	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
657323002969	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
657323002970	endonuclease III; Region: ENDO3c; smart00478
657323002971	minor groove reading motif; other site
657323002972	helix-hairpin-helix signature motif; other site
657323002973	active site
657323002974	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
657323002975	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
657323002976	Alcohol acetyltransferase; Region: AATase; pfam07247
657323002977	Domain of unknown function, E. rectale Gene description (DUF3877); Region: DUF3877; pfam12993
657323002978	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
657323002979	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
657323002980	minor groove reading motif; other site
657323002981	helix-hairpin-helix signature motif; other site
657323002982	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323002983	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323002984	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
657323002985	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323002986	dimer interface [polypeptide binding]; other site
657323002987	conserved gate region; other site
657323002988	putative PBP binding loops; other site
657323002989	ABC-ATPase subunit interface; other site
657323002990	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
657323002991	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
657323002992	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323002993	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323002994	Q-loop/lid; other site
657323002995	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
657323002996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323002997	dimer interface [polypeptide binding]; other site
657323002998	conserved gate region; other site
657323002999	putative PBP binding loops; other site
657323003000	ABC-ATPase subunit interface; other site
657323003001	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
657323003002	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
657323003003	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
657323003004	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657323003005	Walker A/P-loop; other site
657323003006	ATP binding site [chemical binding]; other site
657323003007	Q-loop/lid; other site
657323003008	ABC transporter signature motif; other site
657323003009	Walker B; other site
657323003010	D-loop; other site
657323003011	H-loop/switch region; other site
657323003012	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
657323003013	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657323003014	Walker A/P-loop; other site
657323003015	ATP binding site [chemical binding]; other site
657323003016	ABC transporter; Region: ABC_tran; pfam00005
657323003017	Q-loop/lid; other site
657323003018	ABC transporter signature motif; other site
657323003019	Walker B; other site
657323003020	D-loop; other site
657323003021	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657323003022	Coenzyme A binding pocket [chemical binding]; other site
657323003023	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
657323003024	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657323003025	active site
657323003026	metal binding site [ion binding]; metal-binding site
657323003027	homotetramer interface [polypeptide binding]; other site
657323003028	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
657323003029	LrgB-like family; Region: LrgB; cl00596
657323003030	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323003031	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323003032	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
657323003033	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323003034	Predicted transcriptional regulator [Transcription]; Region: COG2378
657323003035	WYL domain; Region: WYL; pfam13280
657323003036	Biotin operon repressor [Transcription]; Region: BirA; COG1654
657323003037	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
657323003038	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
657323003039	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
657323003040	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
657323003041	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
657323003042	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
657323003043	core domain interface [polypeptide binding]; other site
657323003044	delta subunit interface [polypeptide binding]; other site
657323003045	epsilon subunit interface [polypeptide binding]; other site
657323003046	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
657323003047	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
657323003048	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
657323003049	alpha subunit interaction interface [polypeptide binding]; other site
657323003050	Walker A motif; other site
657323003051	ATP binding site [chemical binding]; other site
657323003052	Walker B motif; other site
657323003053	inhibitor binding site; inhibition site
657323003054	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
657323003055	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
657323003056	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
657323003057	gamma subunit interface [polypeptide binding]; other site
657323003058	epsilon subunit interface [polypeptide binding]; other site
657323003059	LBP interface [polypeptide binding]; other site
657323003060	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
657323003061	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657323003062	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
657323003063	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
657323003064	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
657323003065	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
657323003066	active site
657323003067	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657323003068	Coenzyme A binding pocket [chemical binding]; other site
657323003069	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
657323003070	active site
657323003071	catalytic triad [active]
657323003072	oxyanion hole [active]
657323003073	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
657323003074	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
657323003075	active site
657323003076	dimer interface [polypeptide binding]; other site
657323003077	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
657323003078	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657323003079	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
657323003080	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657323003081	Walker A motif; other site
657323003082	ATP binding site [chemical binding]; other site
657323003083	Walker B motif; other site
657323003084	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
657323003085	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657323003086	catalytic residues [active]
657323003087	Recombinase; Region: Recombinase; pfam07508
657323003088	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657323003089	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323003090	non-specific DNA binding site [nucleotide binding]; other site
657323003091	salt bridge; other site
657323003092	sequence-specific DNA binding site [nucleotide binding]; other site
657323003093	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
657323003094	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
657323003095	Methyltransferase domain; Region: Methyltransf_26; pfam13659
657323003096	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
657323003097	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
657323003098	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
657323003099	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
657323003100	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
657323003101	active site
657323003102	metal binding site [ion binding]; metal-binding site
657323003103	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323003104	sequence-specific DNA binding site [nucleotide binding]; other site
657323003105	salt bridge; other site
657323003106	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
657323003107	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323003108	active site
657323003109	DNA binding site [nucleotide binding]
657323003110	Int/Topo IB signature motif; other site
657323003111	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657323003112	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657323003113	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
657323003114	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
657323003115	dimer interface [polypeptide binding]; other site
657323003116	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323003117	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
657323003118	phosphorylation site [posttranslational modification]
657323003119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323003120	ATP binding site [chemical binding]; other site
657323003121	Mg2+ binding site [ion binding]; other site
657323003122	G-X-G motif; other site
657323003123	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
657323003124	HIT family signature motif; other site
657323003125	catalytic residue [active]
657323003126	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
657323003127	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
657323003128	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
657323003129	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
657323003130	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
657323003131	Beta-Casp domain; Region: Beta-Casp; smart01027
657323003132	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
657323003133	TSCPD domain; Region: TSCPD; cl14834
657323003134	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
657323003135	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
657323003136	Methyltransferase domain; Region: Methyltransf_31; pfam13847
657323003137	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323003138	S-adenosylmethionine binding site [chemical binding]; other site
657323003139	Methyltransferase TRM13; Region: TRM13; pfam05206
657323003140	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
657323003141	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
657323003142	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
657323003143	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
657323003144	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
657323003145	active site
657323003146	catalytic triad [active]
657323003147	oxyanion hole [active]
657323003148	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
657323003149	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
657323003150	putative dimer interface [polypeptide binding]; other site
657323003151	putative anticodon binding site; other site
657323003152	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
657323003153	homodimer interface [polypeptide binding]; other site
657323003154	motif 1; other site
657323003155	motif 2; other site
657323003156	active site
657323003157	motif 3; other site
657323003158	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
657323003159	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657323003160	active site
657323003161	metal binding site [ion binding]; metal-binding site
657323003162	DNA binding site [nucleotide binding]
657323003163	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323003164	AAA domain; Region: AAA_23; pfam13476
657323003165	Walker A/P-loop; other site
657323003166	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323003167	Q-loop/lid; other site
657323003168	ABC transporter signature motif; other site
657323003169	Walker B; other site
657323003170	H-loop/switch region; other site
657323003171	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657323003172	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
657323003173	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
657323003174	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657323003175	active site
657323003176	DNA replication protein DnaC; Validated; Region: PRK06835
657323003177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323003178	Walker A motif; other site
657323003179	ATP binding site [chemical binding]; other site
657323003180	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
657323003181	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
657323003182	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
657323003183	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
657323003184	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
657323003185	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
657323003186	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
657323003187	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
657323003188	ligand binding site; other site
657323003189	oligomer interface; other site
657323003190	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
657323003191	dimer interface [polypeptide binding]; other site
657323003192	N-terminal domain interface [polypeptide binding]; other site
657323003193	sulfate 1 binding site; other site
657323003194	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
657323003195	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
657323003196	ligand binding site; other site
657323003197	oligomer interface; other site
657323003198	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
657323003199	dimer interface [polypeptide binding]; other site
657323003200	N-terminal domain interface [polypeptide binding]; other site
657323003201	regulatory protein SpoVG; Reviewed; Region: PRK13259
657323003202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
657323003203	3D domain; Region: 3D; cl01439
657323003204	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816
657323003205	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
657323003206	putative hexamer interface [polypeptide binding]; other site
657323003207	putative hexagonal pore; other site
657323003208	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
657323003209	putative hexamer interface [polypeptide binding]; other site
657323003210	putative hexagonal pore; other site
657323003211	BioY family; Region: BioY; pfam02632
657323003212	Protein of unknown function (DUF1284); Region: DUF1284; pfam06935
657323003213	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
657323003214	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
657323003215	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
657323003216	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
657323003217	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
657323003218	Yqey-like protein; Region: YqeY; cl17540
657323003219	6-phosphofructokinase; Provisional; Region: PRK03202
657323003220	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
657323003221	active site
657323003222	ADP/pyrophosphate binding site [chemical binding]; other site
657323003223	dimerization interface [polypeptide binding]; other site
657323003224	allosteric effector site; other site
657323003225	fructose-1,6-bisphosphate binding site; other site
657323003226	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
657323003227	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323003228	Walker A motif; other site
657323003229	ATP binding site [chemical binding]; other site
657323003230	Walker B motif; other site
657323003231	arginine finger; other site
657323003232	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
657323003233	hypothetical protein; Validated; Region: PRK00153
657323003234	recombination protein RecR; Reviewed; Region: recR; PRK00076
657323003235	RecR protein; Region: RecR; pfam02132
657323003236	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
657323003237	putative active site [active]
657323003238	putative metal-binding site [ion binding]; other site
657323003239	tetramer interface [polypeptide binding]; other site
657323003240	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
657323003241	active site
657323003242	intersubunit interactions; other site
657323003243	catalytic residue [active]
657323003244	transketolase; Reviewed; Region: PRK05899
657323003245	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
657323003246	TPP-binding site [chemical binding]; other site
657323003247	dimer interface [polypeptide binding]; other site
657323003248	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
657323003249	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
657323003250	PYR/PP interface [polypeptide binding]; other site
657323003251	dimer interface [polypeptide binding]; other site
657323003252	TPP binding site [chemical binding]; other site
657323003253	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
657323003254	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
657323003255	Colicin V production protein; Region: Colicin_V; pfam02674
657323003256	integrase; Provisional; Region: int; PHA02601
657323003257	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
657323003258	Int/Topo IB signature motif; other site
657323003259	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
657323003260	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
657323003261	metal binding site [ion binding]; metal-binding site
657323003262	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
657323003263	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323003264	Walker A/P-loop; other site
657323003265	ATP binding site [chemical binding]; other site
657323003266	Q-loop/lid; other site
657323003267	ABC transporter signature motif; other site
657323003268	Walker B; other site
657323003269	D-loop; other site
657323003270	H-loop/switch region; other site
657323003271	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
657323003272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323003273	dimer interface [polypeptide binding]; other site
657323003274	conserved gate region; other site
657323003275	putative PBP binding loops; other site
657323003276	ABC-ATPase subunit interface; other site
657323003277	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
657323003278	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323003279	dimer interface [polypeptide binding]; other site
657323003280	conserved gate region; other site
657323003281	putative PBP binding loops; other site
657323003282	ABC-ATPase subunit interface; other site
657323003283	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
657323003284	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
657323003285	Walker A/P-loop; other site
657323003286	ATP binding site [chemical binding]; other site
657323003287	Q-loop/lid; other site
657323003288	ABC transporter signature motif; other site
657323003289	Walker B; other site
657323003290	D-loop; other site
657323003291	H-loop/switch region; other site
657323003292	TOBE domain; Region: TOBE_2; pfam08402
657323003293	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
657323003294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323003295	dimer interface [polypeptide binding]; other site
657323003296	conserved gate region; other site
657323003297	putative PBP binding loops; other site
657323003298	ABC-ATPase subunit interface; other site
657323003299	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
657323003300	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
657323003301	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
657323003302	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
657323003303	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
657323003304	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
657323003305	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
657323003306	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657323003307	Magnesium ion binding site [ion binding]; other site
657323003308	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
657323003309	Chain length determinant protein; Region: Wzz; cl15801
657323003310	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
657323003311	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
657323003312	CoA-binding domain; Region: CoA_binding_3; pfam13727
657323003313	Bacterial sugar transferase; Region: Bac_transf; cl00939
657323003314	Bacterial sugar transferase; Region: Bac_transf; pfam02397
657323003315	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
657323003316	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
657323003317	NAD(P) binding site [chemical binding]; other site
657323003318	homodimer interface [polypeptide binding]; other site
657323003319	substrate binding site [chemical binding]; other site
657323003320	active site
657323003321	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
657323003322	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
657323003323	inhibitor-cofactor binding pocket; inhibition site
657323003324	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323003325	catalytic residue [active]
657323003326	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
657323003327	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
657323003328	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
657323003329	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
657323003330	Bacterial sugar transferase; Region: Bac_transf; pfam02397
657323003331	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
657323003332	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
657323003333	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
657323003334	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
657323003335	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
657323003336	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
657323003337	active site
657323003338	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
657323003339	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
657323003340	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
657323003341	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
657323003342	active site
657323003343	substrate binding site [chemical binding]; other site
657323003344	metal binding site [ion binding]; metal-binding site
657323003345	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
657323003346	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
657323003347	glutaminase active site [active]
657323003348	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
657323003349	dimer interface [polypeptide binding]; other site
657323003350	active site
657323003351	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
657323003352	dimer interface [polypeptide binding]; other site
657323003353	active site
657323003354	Transcriptional regulator [Transcription]; Region: LytR; COG1316
657323003355	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
657323003356	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
657323003357	NADP binding site [chemical binding]; other site
657323003358	active site
657323003359	putative substrate binding site [chemical binding]; other site
657323003360	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
657323003361	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
657323003362	NAD binding site [chemical binding]; other site
657323003363	substrate binding site [chemical binding]; other site
657323003364	homodimer interface [polypeptide binding]; other site
657323003365	active site
657323003366	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
657323003367	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
657323003368	substrate binding site; other site
657323003369	tetramer interface; other site
657323003370	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
657323003371	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
657323003372	DNA binding residues [nucleotide binding]
657323003373	dimer interface [polypeptide binding]; other site
657323003374	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
657323003375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323003376	S-adenosylmethionine binding site [chemical binding]; other site
657323003377	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
657323003378	Acyltransferase family; Region: Acyl_transf_3; pfam01757
657323003379	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
657323003380	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
657323003381	ligand binding site; other site
657323003382	oligomer interface; other site
657323003383	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
657323003384	dimer interface [polypeptide binding]; other site
657323003385	N-terminal domain interface [polypeptide binding]; other site
657323003386	sulfate 1 binding site; other site
657323003387	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
657323003388	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
657323003389	ligand binding site; other site
657323003390	oligomer interface; other site
657323003391	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
657323003392	dimer interface [polypeptide binding]; other site
657323003393	N-terminal domain interface [polypeptide binding]; other site
657323003394	sulfate 1 binding site; other site
657323003395	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
657323003396	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
657323003397	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
657323003398	Walker A/P-loop; other site
657323003399	ATP binding site [chemical binding]; other site
657323003400	Q-loop/lid; other site
657323003401	ABC transporter signature motif; other site
657323003402	Walker B; other site
657323003403	D-loop; other site
657323003404	H-loop/switch region; other site
657323003405	argininosuccinate lyase; Provisional; Region: PRK00855
657323003406	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
657323003407	active sites [active]
657323003408	tetramer interface [polypeptide binding]; other site
657323003409	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
657323003410	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
657323003411	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
657323003412	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
657323003413	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
657323003414	active site
657323003415	putative interdomain interaction site [polypeptide binding]; other site
657323003416	putative metal-binding site [ion binding]; other site
657323003417	putative nucleotide binding site [chemical binding]; other site
657323003418	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
657323003419	domain I; other site
657323003420	phosphate binding site [ion binding]; other site
657323003421	Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636
657323003422	conjugal transfer protein TrbP; Provisional; Region: PRK13882
657323003423	TraX protein; Region: TraX; pfam05857
657323003424	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
657323003425	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
657323003426	GGGtGRT protein; Region: GGGtGRT; pfam14057
657323003427	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
657323003428	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
657323003429	homodimer interface [polypeptide binding]; other site
657323003430	substrate-cofactor binding pocket; other site
657323003431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323003432	catalytic residue [active]
657323003433	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
657323003434	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
657323003435	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
657323003436	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
657323003437	MFS/sugar transport protein; Region: MFS_2; pfam13347
657323003438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657323003439	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
657323003440	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
657323003441	L-aspartate oxidase; Provisional; Region: PRK06175
657323003442	FAD binding domain; Region: FAD_binding_2; pfam00890
657323003443	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
657323003444	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
657323003445	HTH domain; Region: HTH_11; pfam08279
657323003446	3H domain; Region: 3H; pfam02829
657323003447	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
657323003448	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
657323003449	Nitrogen regulatory protein P-II; Region: P-II; smart00938
657323003450	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
657323003451	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
657323003452	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
657323003453	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
657323003454	amidophosphoribosyltransferase; Provisional; Region: PRK05793
657323003455	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
657323003456	active site
657323003457	tetramer interface [polypeptide binding]; other site
657323003458	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657323003459	active site
657323003460	CTP synthetase; Validated; Region: pyrG; PRK05380
657323003461	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
657323003462	Catalytic site [active]
657323003463	active site
657323003464	UTP binding site [chemical binding]; other site
657323003465	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
657323003466	active site
657323003467	putative oxyanion hole; other site
657323003468	catalytic triad [active]
657323003469	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
657323003470	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
657323003471	active site
657323003472	dimer interface [polypeptide binding]; other site
657323003473	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
657323003474	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
657323003475	active site
657323003476	FMN binding site [chemical binding]; other site
657323003477	substrate binding site [chemical binding]; other site
657323003478	3Fe-4S cluster binding site [ion binding]; other site
657323003479	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
657323003480	domain interface; other site
657323003481	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
657323003482	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
657323003483	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
657323003484	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
657323003485	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
657323003486	ANTAR domain; Region: ANTAR; pfam03861
657323003487	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
657323003488	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
657323003489	Dimer interface [polypeptide binding]; other site
657323003490	anticodon binding site; other site
657323003491	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
657323003492	homodimer interface [polypeptide binding]; other site
657323003493	motif 1; other site
657323003494	motif 2; other site
657323003495	active site
657323003496	motif 3; other site
657323003497	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
657323003498	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
657323003499	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
657323003500	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
657323003501	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
657323003502	GatB domain; Region: GatB_Yqey; smart00845
657323003503	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
657323003504	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657323003505	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323003506	homodimer interface [polypeptide binding]; other site
657323003507	catalytic residue [active]
657323003508	Cupin domain; Region: Cupin_2; pfam07883
657323003509	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323003510	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323003511	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323003512	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
657323003513	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657323003514	Zn2+ binding site [ion binding]; other site
657323003515	Mg2+ binding site [ion binding]; other site
657323003516	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
657323003517	DNA primase; Validated; Region: dnaG; PRK05667
657323003518	CHC2 zinc finger; Region: zf-CHC2; pfam01807
657323003519	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
657323003520	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
657323003521	active site
657323003522	metal binding site [ion binding]; metal-binding site
657323003523	interdomain interaction site; other site
657323003524	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
657323003525	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
657323003526	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
657323003527	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657323003528	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
657323003529	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657323003530	DNA binding residues [nucleotide binding]
657323003531	Uncharacterized conserved protein [Function unknown]; Region: COG0327
657323003532	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
657323003533	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
657323003534	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
657323003535	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
657323003536	active site
657323003537	selenophosphate synthetase; Provisional; Region: PRK00943
657323003538	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
657323003539	dimerization interface [polypeptide binding]; other site
657323003540	putative ATP binding site [chemical binding]; other site
657323003541	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
657323003542	Na2 binding site [ion binding]; other site
657323003543	putative substrate binding site 1 [chemical binding]; other site
657323003544	Na binding site 1 [ion binding]; other site
657323003545	putative substrate binding site 2 [chemical binding]; other site
657323003546	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
657323003547	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
657323003548	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
657323003549	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
657323003550	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
657323003551	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
657323003552	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
657323003553	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
657323003554	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
657323003555	Chorismate mutase type II; Region: CM_2; smart00830
657323003556	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
657323003557	Prephenate dehydratase; Region: PDT; pfam00800
657323003558	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
657323003559	putative L-Phe binding site [chemical binding]; other site
657323003560	Protein of unknown function (DUF815); Region: DUF815; pfam05673
657323003561	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
657323003562	Walker A motif; other site
657323003563	ATP binding site [chemical binding]; other site
657323003564	Walker B motif; other site
657323003565	arginine finger; other site
657323003566	exopolyphosphatase; Region: exo_poly_only; TIGR03706
657323003567	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
657323003568	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
657323003569	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
657323003570	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
657323003571	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
657323003572	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
657323003573	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657323003574	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657323003575	metal binding site [ion binding]; metal-binding site
657323003576	active site
657323003577	I-site; other site
657323003578	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657323003579	metal binding site [ion binding]; metal-binding site
657323003580	active site
657323003581	I-site; other site
657323003582	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
657323003583	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
657323003584	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323003585	Mg2+ binding site [ion binding]; other site
657323003586	G-X-G motif; other site
657323003587	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
657323003588	anchoring element; other site
657323003589	dimer interface [polypeptide binding]; other site
657323003590	ATP binding site [chemical binding]; other site
657323003591	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
657323003592	active site
657323003593	putative metal-binding site [ion binding]; other site
657323003594	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
657323003595	Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188
657323003596	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
657323003597	CAP-like domain; other site
657323003598	active site
657323003599	primary dimer interface [polypeptide binding]; other site
657323003600	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657323003601	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657323003602	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
657323003603	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
657323003604	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
657323003605	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
657323003606	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
657323003607	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
657323003608	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004
657323003609	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004
657323003610	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004
657323003611	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
657323003612	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
657323003613	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
657323003614	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
657323003615	ribosome maturation protein RimP; Reviewed; Region: PRK00092
657323003616	Sm and related proteins; Region: Sm_like; cl00259
657323003617	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
657323003618	NusA N-terminal domain; Region: NusA_N; pfam08529
657323003619	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
657323003620	RNA binding site [nucleotide binding]; other site
657323003621	homodimer interface [polypeptide binding]; other site
657323003622	NusA-like KH domain; Region: KH_5; pfam13184
657323003623	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
657323003624	G-X-X-G motif; other site
657323003625	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
657323003626	putative RNA binding cleft [nucleotide binding]; other site
657323003627	translation initiation factor IF-2; Region: IF-2; TIGR00487
657323003628	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
657323003629	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
657323003630	G1 box; other site
657323003631	putative GEF interaction site [polypeptide binding]; other site
657323003632	GTP/Mg2+ binding site [chemical binding]; other site
657323003633	Switch I region; other site
657323003634	G2 box; other site
657323003635	G3 box; other site
657323003636	Switch II region; other site
657323003637	G4 box; other site
657323003638	G5 box; other site
657323003639	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
657323003640	Translation-initiation factor 2; Region: IF-2; pfam11987
657323003641	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
657323003642	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
657323003643	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
657323003644	active site
657323003645	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
657323003646	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
657323003647	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
657323003648	active site
657323003649	Riboflavin kinase; Region: Flavokinase; pfam01687
657323003650	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
657323003651	16S/18S rRNA binding site [nucleotide binding]; other site
657323003652	S13e-L30e interaction site [polypeptide binding]; other site
657323003653	25S rRNA binding site [nucleotide binding]; other site
657323003654	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
657323003655	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
657323003656	RNase E interface [polypeptide binding]; other site
657323003657	trimer interface [polypeptide binding]; other site
657323003658	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
657323003659	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
657323003660	RNase E interface [polypeptide binding]; other site
657323003661	trimer interface [polypeptide binding]; other site
657323003662	active site
657323003663	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
657323003664	putative nucleic acid binding region [nucleotide binding]; other site
657323003665	G-X-X-G motif; other site
657323003666	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
657323003667	RNA binding site [nucleotide binding]; other site
657323003668	domain interface; other site
657323003669	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
657323003670	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323003671	FeS/SAM binding site; other site
657323003672	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
657323003673	trimer interface [polypeptide binding]; other site
657323003674	active site
657323003675	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
657323003676	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
657323003677	active site
657323003678	putative catalytic site [active]
657323003679	DNA binding site [nucleotide binding]
657323003680	putative phosphate binding site [ion binding]; other site
657323003681	metal binding site A [ion binding]; metal-binding site
657323003682	AP binding site [nucleotide binding]; other site
657323003683	metal binding site B [ion binding]; metal-binding site
657323003684	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
657323003685	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
657323003686	Peptidase M16C associated; Region: M16C_assoc; pfam08367
657323003687	GTPase Era; Reviewed; Region: era; PRK00089
657323003688	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
657323003689	G1 box; other site
657323003690	GTP/Mg2+ binding site [chemical binding]; other site
657323003691	Switch I region; other site
657323003692	G2 box; other site
657323003693	Switch II region; other site
657323003694	G3 box; other site
657323003695	G4 box; other site
657323003696	G5 box; other site
657323003697	KH domain; Region: KH_2; pfam07650
657323003698	Recombination protein O N terminal; Region: RecO_N; pfam11967
657323003699	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
657323003700	Recombination protein O C terminal; Region: RecO_C; pfam02565
657323003701	glycyl-tRNA synthetase; Provisional; Region: PRK04173
657323003702	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
657323003703	motif 1; other site
657323003704	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
657323003705	active site
657323003706	motif 2; other site
657323003707	motif 3; other site
657323003708	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
657323003709	anticodon binding site; other site
657323003710	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657323003711	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
657323003712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323003713	dimer interface [polypeptide binding]; other site
657323003714	conserved gate region; other site
657323003715	putative PBP binding loops; other site
657323003716	ABC-ATPase subunit interface; other site
657323003717	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657323003718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323003719	dimer interface [polypeptide binding]; other site
657323003720	conserved gate region; other site
657323003721	putative PBP binding loops; other site
657323003722	ABC-ATPase subunit interface; other site
657323003723	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
657323003724	Melibiase; Region: Melibiase; pfam02065
657323003725	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
657323003726	active site
657323003727	catalytic residues [active]
657323003728	pyruvate phosphate dikinase; Provisional; Region: PRK09279
657323003729	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
657323003730	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
657323003731	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
657323003732	MraW methylase family; Region: Methyltransf_5; cl17771
657323003733	Predicted membrane protein [Function unknown]; Region: COG2246
657323003734	GtrA-like protein; Region: GtrA; pfam04138
657323003735	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323003736	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657323003737	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
657323003738	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
657323003739	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
657323003740	glutamine binding [chemical binding]; other site
657323003741	catalytic triad [active]
657323003742	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
657323003743	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
657323003744	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
657323003745	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
657323003746	homodimer interface [polypeptide binding]; other site
657323003747	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
657323003748	Aminotransferase class IV; Region: Aminotran_4; pfam01063
657323003749	substrate-cofactor binding pocket; other site
657323003750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323003751	catalytic residue [active]
657323003752	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
657323003753	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
657323003754	putative substrate binding site [chemical binding]; other site
657323003755	putative ATP binding site [chemical binding]; other site
657323003756	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
657323003757	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
657323003758	active site
657323003759	phosphorylation site [posttranslational modification]
657323003760	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
657323003761	active site
657323003762	P-loop; other site
657323003763	phosphorylation site [posttranslational modification]
657323003764	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
657323003765	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
657323003766	dimerization domain swap beta strand [polypeptide binding]; other site
657323003767	regulatory protein interface [polypeptide binding]; other site
657323003768	active site
657323003769	regulatory phosphorylation site [posttranslational modification]; other site
657323003770	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657323003771	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657323003772	metal binding site [ion binding]; metal-binding site
657323003773	active site
657323003774	I-site; other site
657323003775	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
657323003776	homodimer interaction site [polypeptide binding]; other site
657323003777	cofactor binding site; other site
657323003778	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
657323003779	aspartate kinase; Reviewed; Region: PRK09034
657323003780	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
657323003781	nucleotide binding site [chemical binding]; other site
657323003782	substrate binding site [chemical binding]; other site
657323003783	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
657323003784	allosteric regulatory residue; other site
657323003785	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
657323003786	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
657323003787	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
657323003788	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
657323003789	homotrimer interaction site [polypeptide binding]; other site
657323003790	putative active site [active]
657323003791	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
657323003792	homotrimer interaction site [polypeptide binding]; other site
657323003793	zinc binding site [ion binding]; other site
657323003794	CDP-binding sites; other site
657323003795	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
657323003796	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
657323003797	active site
657323003798	HIGH motif; other site
657323003799	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
657323003800	KMSKS motif; other site
657323003801	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
657323003802	tRNA binding surface [nucleotide binding]; other site
657323003803	anticodon binding site; other site
657323003804	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
657323003805	active site
657323003806	metal binding site [ion binding]; metal-binding site
657323003807	dimerization interface [polypeptide binding]; other site
657323003808	RNA polymerase factor sigma-70; Validated; Region: PRK08295
657323003809	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657323003810	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
657323003811	DNA binding residues [nucleotide binding]
657323003812	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657323003813	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323003814	non-specific DNA binding site [nucleotide binding]; other site
657323003815	salt bridge; other site
657323003816	sequence-specific DNA binding site [nucleotide binding]; other site
657323003817	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
657323003818	putative active site [active]
657323003819	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657323003820	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
657323003821	catalytic residues [active]
657323003822	catalytic nucleophile [active]
657323003823	Presynaptic Site I dimer interface [polypeptide binding]; other site
657323003824	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
657323003825	Synaptic Flat tetramer interface [polypeptide binding]; other site
657323003826	Synaptic Site I dimer interface [polypeptide binding]; other site
657323003827	DNA binding site [nucleotide binding]
657323003828	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
657323003829	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
657323003830	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
657323003831	BRO family, N-terminal domain; Region: Bro-N; cl10591
657323003832	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
657323003833	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
657323003834	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323003835	active site
657323003836	DNA binding site [nucleotide binding]
657323003837	Int/Topo IB signature motif; other site
657323003838	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
657323003839	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657323003840	active site
657323003841	HIGH motif; other site
657323003842	nucleotide binding site [chemical binding]; other site
657323003843	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657323003844	active site
657323003845	KMSKS motif; other site
657323003846	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
657323003847	Maf-like protein; Region: Maf; pfam02545
657323003848	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
657323003849	active site
657323003850	dimer interface [polypeptide binding]; other site
657323003851	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
657323003852	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323003853	motif II; other site
657323003854	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
657323003855	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323003856	active site
657323003857	motif I; other site
657323003858	motif II; other site
657323003859	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
657323003860	heat shock protein 90; Provisional; Region: PRK05218
657323003861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323003862	ATP binding site [chemical binding]; other site
657323003863	Mg2+ binding site [ion binding]; other site
657323003864	G-X-G motif; other site
657323003865	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
657323003866	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
657323003867	DNA-binding site [nucleotide binding]; DNA binding site
657323003868	RNA-binding motif; other site
657323003869	dihydroorotase; Validated; Region: pyrC; PRK09357
657323003870	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
657323003871	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
657323003872	active site
657323003873	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
657323003874	active site
657323003875	dimer interface [polypeptide binding]; other site
657323003876	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
657323003877	FAD binding pocket [chemical binding]; other site
657323003878	FAD binding motif [chemical binding]; other site
657323003879	phosphate binding motif [ion binding]; other site
657323003880	beta-alpha-beta structure motif; other site
657323003881	NAD binding pocket [chemical binding]; other site
657323003882	Iron coordination center [ion binding]; other site
657323003883	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
657323003884	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
657323003885	heterodimer interface [polypeptide binding]; other site
657323003886	active site
657323003887	FMN binding site [chemical binding]; other site
657323003888	homodimer interface [polypeptide binding]; other site
657323003889	substrate binding site [chemical binding]; other site
657323003890	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657323003891	active site
657323003892	HD domain; Region: HD_3; pfam13023
657323003893	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
657323003894	AIR carboxylase; Region: AIRC; pfam00731
657323003895	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
657323003896	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
657323003897	dimerization interface [polypeptide binding]; other site
657323003898	putative ATP binding site [chemical binding]; other site
657323003899	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
657323003900	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
657323003901	active site
657323003902	substrate binding site [chemical binding]; other site
657323003903	cosubstrate binding site; other site
657323003904	catalytic site [active]
657323003905	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
657323003906	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
657323003907	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
657323003908	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
657323003909	Predicted transcriptional regulators [Transcription]; Region: COG1725
657323003910	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657323003911	DNA-binding site [nucleotide binding]; DNA binding site
657323003912	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
657323003913	Clp amino terminal domain; Region: Clp_N; pfam02861
657323003914	Clp amino terminal domain; Region: Clp_N; pfam02861
657323003915	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323003916	Walker A motif; other site
657323003917	ATP binding site [chemical binding]; other site
657323003918	Walker B motif; other site
657323003919	arginine finger; other site
657323003920	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323003921	Walker A motif; other site
657323003922	ATP binding site [chemical binding]; other site
657323003923	Walker B motif; other site
657323003924	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
657323003925	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
657323003926	DNA repair protein RadA; Provisional; Region: PRK11823
657323003927	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
657323003928	Walker A motif/ATP binding site; other site
657323003929	ATP binding site [chemical binding]; other site
657323003930	Walker B motif; other site
657323003931	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
657323003932	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
657323003933	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
657323003934	substrate binding site; other site
657323003935	dimer interface; other site
657323003936	UGMP family protein; Validated; Region: PRK09604
657323003937	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
657323003938	ribonuclease Z; Reviewed; Region: PRK00055
657323003939	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
657323003940	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657323003941	Coenzyme A binding pocket [chemical binding]; other site
657323003942	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
657323003943	Glycoprotease family; Region: Peptidase_M22; pfam00814
657323003944	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
657323003945	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
657323003946	active site
657323003947	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
657323003948	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
657323003949	Uncharacterized conserved protein [Function unknown]; Region: COG1739
657323003950	Transglycosylase; Region: Transgly; pfam00912
657323003951	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
657323003952	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
657323003953	nucleotide binding site [chemical binding]; other site
657323003954	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
657323003955	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
657323003956	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
657323003957	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
657323003958	Hpr binding site; other site
657323003959	active site
657323003960	homohexamer subunit interaction site [polypeptide binding]; other site
657323003961	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
657323003962	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
657323003963	GIY-YIG motif/motif A; other site
657323003964	active site
657323003965	catalytic site [active]
657323003966	putative DNA binding site [nucleotide binding]; other site
657323003967	metal binding site [ion binding]; metal-binding site
657323003968	UvrB/uvrC motif; Region: UVR; pfam02151
657323003969	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
657323003970	FtsH Extracellular; Region: FtsH_ext; pfam06480
657323003971	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
657323003972	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323003973	Walker A motif; other site
657323003974	ATP binding site [chemical binding]; other site
657323003975	Walker B motif; other site
657323003976	arginine finger; other site
657323003977	Peptidase family M41; Region: Peptidase_M41; pfam01434
657323003978	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
657323003979	Domain of unknown function (DUF1846); Region: DUF1846; pfam08903
657323003980	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
657323003981	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
657323003982	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657323003983	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323003984	dimer interface [polypeptide binding]; other site
657323003985	conserved gate region; other site
657323003986	ABC-ATPase subunit interface; other site
657323003987	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323003988	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
657323003989	Response regulator receiver domain; Region: Response_reg; pfam00072
657323003990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323003991	active site
657323003992	phosphorylation site [posttranslational modification]
657323003993	intermolecular recognition site; other site
657323003994	dimerization interface [polypeptide binding]; other site
657323003995	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323003996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323003997	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
657323003998	AAA domain; Region: AAA_23; pfam13476
657323003999	Walker A/P-loop; other site
657323004000	ATP binding site [chemical binding]; other site
657323004001	Q-loop/lid; other site
657323004002	ABC transporter signature motif; other site
657323004003	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
657323004004	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657323004005	active site
657323004006	metal binding site [ion binding]; metal-binding site
657323004007	DNA binding site [nucleotide binding]
657323004008	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
657323004009	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
657323004010	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
657323004011	active site
657323004012	catalytic tetrad [active]
657323004013	L-fucose isomerase; Provisional; Region: fucI; PRK10991
657323004014	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
657323004015	hexamer (dimer of trimers) interface [polypeptide binding]; other site
657323004016	trimer interface [polypeptide binding]; other site
657323004017	substrate binding site [chemical binding]; other site
657323004018	Mn binding site [ion binding]; other site
657323004019	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
657323004020	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
657323004021	ATP binding site [chemical binding]; other site
657323004022	putative Mg++ binding site [ion binding]; other site
657323004023	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
657323004024	nucleotide binding region [chemical binding]; other site
657323004025	ATP-binding site [chemical binding]; other site
657323004026	RQC domain; Region: RQC; pfam09382
657323004027	HRDC domain; Region: HRDC; pfam00570
657323004028	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
657323004029	Domain of unknown function (DUF336); Region: DUF336; pfam03928
657323004030	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
657323004031	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
657323004032	putative active site [active]
657323004033	metal binding site [ion binding]; metal-binding site
657323004034	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
657323004035	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
657323004036	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
657323004037	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
657323004038	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
657323004039	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
657323004040	putative hexamer interface [polypeptide binding]; other site
657323004041	putative hexagonal pore; other site
657323004042	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
657323004043	putative hexamer interface [polypeptide binding]; other site
657323004044	putative hexagonal pore; other site
657323004045	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
657323004046	SLBB domain; Region: SLBB; pfam10531
657323004047	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
657323004048	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
657323004049	Hexamer/Pentamer interface [polypeptide binding]; other site
657323004050	central pore; other site
657323004051	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
657323004052	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
657323004053	Hexamer interface [polypeptide binding]; other site
657323004054	Hexagonal pore residue; other site
657323004055	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
657323004056	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cd06169
657323004057	Hexamer interface [polypeptide binding]; other site
657323004058	Hexagonal pore residue; other site
657323004059	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
657323004060	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
657323004061	Hexamer interface [polypeptide binding]; other site
657323004062	Hexagonal pore residue; other site
657323004063	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
657323004064	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
657323004065	Hexamer interface [polypeptide binding]; other site
657323004066	Hexagonal pore residue; other site
657323004067	Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231
657323004068	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
657323004069	catalytic Zn binding site [ion binding]; other site
657323004070	structural Zn binding site [ion binding]; other site
657323004071	tetramer interface [polypeptide binding]; other site
657323004072	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
657323004073	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
657323004074	putative catalytic cysteine [active]
657323004075	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
657323004076	intersubunit interface [polypeptide binding]; other site
657323004077	active site
657323004078	Zn2+ binding site [ion binding]; other site
657323004079	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
657323004080	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323004081	FeS/SAM binding site; other site
657323004082	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
657323004083	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
657323004084	dimer interface [polypeptide binding]; other site
657323004085	active site
657323004086	glycine loop; other site
657323004087	putative hydrolase; Validated; Region: PRK09248
657323004088	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
657323004089	active site
657323004090	Cysteine-rich small domain; Region: zf-like; pfam04071
657323004091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
657323004092	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
657323004093	NlpC/P60 family; Region: NLPC_P60; pfam00877
657323004094	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
657323004095	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
657323004096	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
657323004097	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
657323004098	HSP70 interaction site [polypeptide binding]; other site
657323004099	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
657323004100	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
657323004101	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
657323004102	putative RNA binding site [nucleotide binding]; other site
657323004103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323004104	S-adenosylmethionine binding site [chemical binding]; other site
657323004105	Predicted secreted protein [Function unknown]; Region: COG4086
657323004106	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
657323004107	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
657323004108	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
657323004109	active site
657323004110	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
657323004111	active site
657323004112	N-terminal domain interface [polypeptide binding]; other site
657323004113	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
657323004114	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
657323004115	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
657323004116	Competence protein; Region: Competence; pfam03772
657323004117	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
657323004118	Sporulation and spore germination; Region: Germane; pfam10646
657323004119	Sporulation and spore germination; Region: Germane; pfam10646
657323004120	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323004121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323004122	active site
657323004123	phosphorylation site [posttranslational modification]
657323004124	intermolecular recognition site; other site
657323004125	dimerization interface [polypeptide binding]; other site
657323004126	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323004127	DNA binding site [nucleotide binding]
657323004128	SLBB domain; Region: SLBB; pfam10531
657323004129	comEA protein; Region: comE; TIGR01259
657323004130	Protein of unknown function, DUF606; Region: DUF606; pfam04657
657323004131	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
657323004132	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
657323004133	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
657323004134	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
657323004135	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657323004136	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
657323004137	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
657323004138	dimerization interface [polypeptide binding]; other site
657323004139	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
657323004140	ATP binding site [chemical binding]; other site
657323004141	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
657323004142	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
657323004143	HupF/HypC family; Region: HupF_HypC; pfam01455
657323004144	Acylphosphatase; Region: Acylphosphatase; pfam00708
657323004145	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
657323004146	HypF finger; Region: zf-HYPF; pfam07503
657323004147	HypF finger; Region: zf-HYPF; pfam07503
657323004148	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
657323004149	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
657323004150	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
657323004151	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
657323004152	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657323004153	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
657323004154	metal-binding site [ion binding]
657323004155	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
657323004156	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
657323004157	G1 box; other site
657323004158	GTP/Mg2+ binding site [chemical binding]; other site
657323004159	Switch I region; other site
657323004160	G2 box; other site
657323004161	G3 box; other site
657323004162	Switch II region; other site
657323004163	G4 box; other site
657323004164	G5 box; other site
657323004165	Nucleoside recognition; Region: Gate; pfam07670
657323004166	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
657323004167	Nucleoside recognition; Region: Gate; pfam07670
657323004168	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
657323004169	FeoA domain; Region: FeoA; pfam04023
657323004170	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
657323004171	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
657323004172	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
657323004173	transmembrane helices; other site
657323004174	acetylornithine aminotransferase; Provisional; Region: PRK02627
657323004175	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
657323004176	inhibitor-cofactor binding pocket; inhibition site
657323004177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323004178	catalytic residue [active]
657323004179	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
657323004180	feedback inhibition sensing region; other site
657323004181	homohexameric interface [polypeptide binding]; other site
657323004182	nucleotide binding site [chemical binding]; other site
657323004183	N-acetyl-L-glutamate binding site [chemical binding]; other site
657323004184	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
657323004185	heterotetramer interface [polypeptide binding]; other site
657323004186	active site pocket [active]
657323004187	cleavage site
657323004188	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
657323004189	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
657323004190	argininosuccinate synthase; Provisional; Region: PRK13820
657323004191	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
657323004192	ANP binding site [chemical binding]; other site
657323004193	Substrate Binding Site II [chemical binding]; other site
657323004194	Substrate Binding Site I [chemical binding]; other site
657323004195	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
657323004196	EamA-like transporter family; Region: EamA; pfam00892
657323004197	EamA-like transporter family; Region: EamA; pfam00892
657323004198	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
657323004199	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
657323004200	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
657323004201	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323004202	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657323004203	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323004204	Walker A/P-loop; other site
657323004205	ATP binding site [chemical binding]; other site
657323004206	Q-loop/lid; other site
657323004207	ABC transporter signature motif; other site
657323004208	Walker B; other site
657323004209	D-loop; other site
657323004210	H-loop/switch region; other site
657323004211	Transglutaminase/protease-like homologues; Region: TGc; smart00460
657323004212	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
657323004213	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657323004214	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657323004215	metal binding site [ion binding]; metal-binding site
657323004216	active site
657323004217	I-site; other site
657323004218	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
657323004219	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657323004220	Zn2+ binding site [ion binding]; other site
657323004221	Mg2+ binding site [ion binding]; other site
657323004222	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
657323004223	GAF domain; Region: GAF_3; pfam13492
657323004224	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
657323004225	Phospholipid methyltransferase; Region: PEMT; cl17370
657323004226	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
657323004227	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657323004228	active site
657323004229	metal binding site [ion binding]; metal-binding site
657323004230	homotetramer interface [polypeptide binding]; other site
657323004231	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
657323004232	active site
657323004233	dimerization interface [polypeptide binding]; other site
657323004234	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
657323004235	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
657323004236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
657323004237	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
657323004238	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657323004239	active site
657323004240	metal binding site [ion binding]; metal-binding site
657323004241	homotetramer interface [polypeptide binding]; other site
657323004242	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
657323004243	active site residue [active]
657323004244	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
657323004245	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
657323004246	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
657323004247	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
657323004248	active site
657323004249	substrate-binding site [chemical binding]; other site
657323004250	metal-binding site [ion binding]
657323004251	ATP binding site [chemical binding]; other site
657323004252	Uncharacterized conserved protein [Function unknown]; Region: COG2966
657323004253	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
657323004254	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
657323004255	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323004256	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323004257	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657323004258	dimerization interface [polypeptide binding]; other site
657323004259	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
657323004260	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
657323004261	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
657323004262	active site turn [active]
657323004263	phosphorylation site [posttranslational modification]
657323004264	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
657323004265	HPr interaction site; other site
657323004266	glycerol kinase (GK) interaction site [polypeptide binding]; other site
657323004267	active site
657323004268	phosphorylation site [posttranslational modification]
657323004269	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323004270	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657323004271	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
657323004272	Walker A/P-loop; other site
657323004273	ATP binding site [chemical binding]; other site
657323004274	Q-loop/lid; other site
657323004275	ABC transporter signature motif; other site
657323004276	Walker B; other site
657323004277	D-loop; other site
657323004278	H-loop/switch region; other site
657323004279	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
657323004280	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657323004281	P-loop; other site
657323004282	Magnesium ion binding site [ion binding]; other site
657323004283	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657323004284	Magnesium ion binding site [ion binding]; other site
657323004285	isoaspartyl dipeptidase; Provisional; Region: PRK10657
657323004286	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
657323004287	active site
657323004288	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
657323004289	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
657323004290	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
657323004291	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
657323004292	Transposase domain (DUF772); Region: DUF772; pfam05598
657323004293	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
657323004294	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
657323004295	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
657323004296	putative ligand binding site [chemical binding]; other site
657323004297	Response regulator receiver domain; Region: Response_reg; pfam00072
657323004298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323004299	active site
657323004300	phosphorylation site [posttranslational modification]
657323004301	intermolecular recognition site; other site
657323004302	dimerization interface [polypeptide binding]; other site
657323004303	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323004304	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323004305	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323004306	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657323004307	dimerization interface [polypeptide binding]; other site
657323004308	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
657323004309	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657323004310	ligand binding site [chemical binding]; other site
657323004311	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
657323004312	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
657323004313	myosin-cross-reactive antigen; Provisional; Region: PRK13977
657323004314	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
657323004315	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
657323004316	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
657323004317	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
657323004318	putative N- and C-terminal domain interface [polypeptide binding]; other site
657323004319	putative active site [active]
657323004320	MgATP binding site [chemical binding]; other site
657323004321	catalytic site [active]
657323004322	metal binding site [ion binding]; metal-binding site
657323004323	putative carbohydrate binding site [chemical binding]; other site
657323004324	L-arabinose isomerase; Region: Arabinose_Isome; pfam02610
657323004325	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
657323004326	alpha-galactosidase; Provisional; Region: PRK15076
657323004327	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
657323004328	NAD binding site [chemical binding]; other site
657323004329	sugar binding site [chemical binding]; other site
657323004330	divalent metal binding site [ion binding]; other site
657323004331	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
657323004332	dimer interface [polypeptide binding]; other site
657323004333	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657323004334	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323004335	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
657323004336	Melibiase; Region: Melibiase; pfam02065
657323004337	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657323004338	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323004339	dimer interface [polypeptide binding]; other site
657323004340	conserved gate region; other site
657323004341	putative PBP binding loops; other site
657323004342	ABC-ATPase subunit interface; other site
657323004343	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
657323004344	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323004345	ABC-ATPase subunit interface; other site
657323004346	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323004347	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657323004348	Protein of unknown function, DUF624; Region: DUF624; pfam04854
657323004349	Protein of unknown function, DUF624; Region: DUF624; cl02369
657323004350	KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592
657323004351	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
657323004352	putative active site [active]
657323004353	putative catalytic site [active]
657323004354	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323004355	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323004356	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323004357	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
657323004358	ABC1 family; Region: ABC1; cl17513
657323004359	Uncharacterized conserved protein [Function unknown]; Region: COG3937
657323004360	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
657323004361	FtsX-like permease family; Region: FtsX; pfam02687
657323004362	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657323004363	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657323004364	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657323004365	Walker A/P-loop; other site
657323004366	ATP binding site [chemical binding]; other site
657323004367	Q-loop/lid; other site
657323004368	ABC transporter signature motif; other site
657323004369	Walker B; other site
657323004370	D-loop; other site
657323004371	H-loop/switch region; other site
657323004372	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
657323004373	Domain of unknown function DUF21; Region: DUF21; pfam01595
657323004374	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
657323004375	Transporter associated domain; Region: CorC_HlyC; pfam03471
657323004376	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
657323004377	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
657323004378	PYR/PP interface [polypeptide binding]; other site
657323004379	dimer interface [polypeptide binding]; other site
657323004380	TPP binding site [chemical binding]; other site
657323004381	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
657323004382	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
657323004383	TPP-binding site [chemical binding]; other site
657323004384	dimer interface [polypeptide binding]; other site
657323004385	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
657323004386	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
657323004387	putative valine binding site [chemical binding]; other site
657323004388	dimer interface [polypeptide binding]; other site
657323004389	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
657323004390	MFS/sugar transport protein; Region: MFS_2; pfam13347
657323004391	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657323004392	putative substrate translocation pore; other site
657323004393	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
657323004394	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
657323004395	active site
657323004396	metal binding site [ion binding]; metal-binding site
657323004397	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
657323004398	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
657323004399	putative NAD(P) binding site [chemical binding]; other site
657323004400	catalytic Zn binding site [ion binding]; other site
657323004401	structural Zn binding site [ion binding]; other site
657323004402	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
657323004403	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
657323004404	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
657323004405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323004406	S-adenosylmethionine binding site [chemical binding]; other site
657323004407	CGGC domain; Region: CGGC; cl02356
657323004408	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
657323004409	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323004410	Walker A/P-loop; other site
657323004411	ATP binding site [chemical binding]; other site
657323004412	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
657323004413	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
657323004414	intersubunit interface [polypeptide binding]; other site
657323004415	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
657323004416	Part of AAA domain; Region: AAA_19; pfam13245
657323004417	Family description; Region: UvrD_C_2; pfam13538
657323004418	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
657323004419	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
657323004420	Trp repressor protein; Region: Trp_repressor; cl17266
657323004421	Protein of unknown function, DUF624; Region: DUF624; pfam04854
657323004422	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
657323004423	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323004424	FeS/SAM binding site; other site
657323004425	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
657323004426	putative DNA binding site [nucleotide binding]; other site
657323004427	putative Zn2+ binding site [ion binding]; other site
657323004428	recombination factor protein RarA; Reviewed; Region: PRK13342
657323004429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323004430	Walker A motif; other site
657323004431	ATP binding site [chemical binding]; other site
657323004432	Walker B motif; other site
657323004433	arginine finger; other site
657323004434	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
657323004435	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
657323004436	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
657323004437	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
657323004438	Walker A/P-loop; other site
657323004439	ATP binding site [chemical binding]; other site
657323004440	Q-loop/lid; other site
657323004441	ABC transporter signature motif; other site
657323004442	Walker B; other site
657323004443	D-loop; other site
657323004444	H-loop/switch region; other site
657323004445	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
657323004446	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
657323004447	Walker A/P-loop; other site
657323004448	ATP binding site [chemical binding]; other site
657323004449	Q-loop/lid; other site
657323004450	ABC transporter signature motif; other site
657323004451	Walker B; other site
657323004452	D-loop; other site
657323004453	H-loop/switch region; other site
657323004454	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
657323004455	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
657323004456	TM-ABC transporter signature motif; other site
657323004457	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
657323004458	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
657323004459	putative ligand binding site [chemical binding]; other site
657323004460	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
657323004461	23S rRNA binding site [nucleotide binding]; other site
657323004462	L21 binding site [polypeptide binding]; other site
657323004463	L13 binding site [polypeptide binding]; other site
657323004464	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
657323004465	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
657323004466	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
657323004467	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
657323004468	cell division protein FtsZ; Validated; Region: PRK09330
657323004469	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
657323004470	nucleotide binding site [chemical binding]; other site
657323004471	SulA interaction site; other site
657323004472	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
657323004473	putative active site [active]
657323004474	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
657323004475	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
657323004476	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
657323004477	NAD(P) binding pocket [chemical binding]; other site
657323004478	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
657323004479	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
657323004480	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
657323004481	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
657323004482	Mg++ binding site [ion binding]; other site
657323004483	putative catalytic motif [active]
657323004484	putative substrate binding site [chemical binding]; other site
657323004485	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
657323004486	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
657323004487	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
657323004488	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
657323004489	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
657323004490	MraW methylase family; Region: Methyltransf_5; cl17771
657323004491	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
657323004492	cell division protein MraZ; Reviewed; Region: PRK00326
657323004493	MraZ protein; Region: MraZ; pfam02381
657323004494	MraZ protein; Region: MraZ; pfam02381
657323004495	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
657323004496	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657323004497	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323004498	Helix-turn-helix domain; Region: HTH_18; pfam12833
657323004499	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323004500	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
657323004501	Thiamine pyrophosphokinase; Region: TPK; cd07995
657323004502	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
657323004503	active site
657323004504	thiamine binding site [chemical binding]; other site
657323004505	dimerization interface [polypeptide binding]; other site
657323004506	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
657323004507	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
657323004508	substrate binding site [chemical binding]; other site
657323004509	hexamer interface [polypeptide binding]; other site
657323004510	metal binding site [ion binding]; metal-binding site
657323004511	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
657323004512	RNA binding site [nucleotide binding]; other site
657323004513	homodimer interface [polypeptide binding]; other site
657323004514	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
657323004515	G4 box; other site
657323004516	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
657323004517	Catalytic domain of Protein Kinases; Region: PKc; cd00180
657323004518	active site
657323004519	ATP binding site [chemical binding]; other site
657323004520	substrate binding site [chemical binding]; other site
657323004521	activation loop (A-loop); other site
657323004522	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
657323004523	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
657323004524	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
657323004525	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
657323004526	active site
657323004527	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
657323004528	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323004529	FeS/SAM binding site; other site
657323004530	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
657323004531	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
657323004532	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
657323004533	putative active site [active]
657323004534	substrate binding site [chemical binding]; other site
657323004535	putative cosubstrate binding site; other site
657323004536	catalytic site [active]
657323004537	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
657323004538	substrate binding site [chemical binding]; other site
657323004539	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
657323004540	active site
657323004541	catalytic residues [active]
657323004542	metal binding site [ion binding]; metal-binding site
657323004543	primosomal protein N' Region: priA; TIGR00595
657323004544	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
657323004545	ATP binding site [chemical binding]; other site
657323004546	putative Mg++ binding site [ion binding]; other site
657323004547	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
657323004548	ATP-binding site [chemical binding]; other site
657323004549	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
657323004550	Domain of unknown function DUF11; Region: DUF11; pfam01345
657323004551	putative amino acid kinase; Reviewed; Region: PRK12353
657323004552	carbamate kinase; Reviewed; Region: PRK12686
657323004553	nucleotide binding site [chemical binding]; other site
657323004554	substrate binding site [chemical binding]; other site
657323004555	ATP cone domain; Region: ATP-cone; pfam03477
657323004556	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
657323004557	Class III ribonucleotide reductase; Region: RNR_III; cd01675
657323004558	effector binding site; other site
657323004559	active site
657323004560	Zn binding site [ion binding]; other site
657323004561	glycine loop; other site
657323004562	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
657323004563	dimer interface [polypeptide binding]; other site
657323004564	active site
657323004565	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
657323004566	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323004567	ABC transporter signature motif; other site
657323004568	Walker B; other site
657323004569	D-loop; other site
657323004570	H-loop/switch region; other site
657323004571	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
657323004572	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323004573	Walker A/P-loop; other site
657323004574	ATP binding site [chemical binding]; other site
657323004575	Q-loop/lid; other site
657323004576	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
657323004577	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
657323004578	membrane-bound complex binding site; other site
657323004579	hinge residues; other site
657323004580	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
657323004581	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
657323004582	substrate binding pocket [chemical binding]; other site
657323004583	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
657323004584	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
657323004585	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
657323004586	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
657323004587	AzlC protein; Region: AzlC; pfam03591
657323004588	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657323004589	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657323004590	Walker A/P-loop; other site
657323004591	ATP binding site [chemical binding]; other site
657323004592	Q-loop/lid; other site
657323004593	ABC transporter signature motif; other site
657323004594	Walker B; other site
657323004595	D-loop; other site
657323004596	H-loop/switch region; other site
657323004597	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323004598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323004599	active site
657323004600	phosphorylation site [posttranslational modification]
657323004601	intermolecular recognition site; other site
657323004602	dimerization interface [polypeptide binding]; other site
657323004603	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323004604	DNA binding site [nucleotide binding]
657323004605	ACT domain-containing protein [General function prediction only]; Region: COG4747
657323004606	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
657323004607	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
657323004608	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
657323004609	ATP cone domain; Region: ATP-cone; pfam03477
657323004610	Class III ribonucleotide reductase; Region: RNR_III; cd01675
657323004611	effector binding site; other site
657323004612	active site
657323004613	Zn binding site [ion binding]; other site
657323004614	glycine loop; other site
657323004615	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
657323004616	catalytic residues [active]
657323004617	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
657323004618	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
657323004619	HflX GTPase family; Region: HflX; cd01878
657323004620	G1 box; other site
657323004621	GTP/Mg2+ binding site [chemical binding]; other site
657323004622	Switch I region; other site
657323004623	G2 box; other site
657323004624	G3 box; other site
657323004625	Switch II region; other site
657323004626	G4 box; other site
657323004627	G5 box; other site
657323004628	TPR repeat; Region: TPR_11; pfam13414
657323004629	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
657323004630	TPR motif; other site
657323004631	binding surface
657323004632	Tetratricopeptide repeat; Region: TPR_16; pfam13432
657323004633	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
657323004634	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
657323004635	active site
657323004636	substrate binding site [chemical binding]; other site
657323004637	metal binding site [ion binding]; metal-binding site
657323004638	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657323004639	active site
657323004640	peptide chain release factor 1; Validated; Region: prfA; PRK00591
657323004641	This domain is found in peptide chain release factors; Region: PCRF; smart00937
657323004642	RF-1 domain; Region: RF-1; pfam00472
657323004643	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
657323004644	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323004645	S-adenosylmethionine binding site [chemical binding]; other site
657323004646	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
657323004647	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
657323004648	transcription termination factor Rho; Provisional; Region: PRK12608
657323004649	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
657323004650	RNA binding site [nucleotide binding]; other site
657323004651	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657323004652	Walker A motif; other site
657323004653	ATP binding site [chemical binding]; other site
657323004654	Walker B motif; other site
657323004655	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
657323004656	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
657323004657	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
657323004658	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
657323004659	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
657323004660	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657323004661	Walker A motif; other site
657323004662	ATP binding site [chemical binding]; other site
657323004663	Walker B motif; other site
657323004664	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
657323004665	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
657323004666	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657323004667	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323004668	homodimer interface [polypeptide binding]; other site
657323004669	catalytic residue [active]
657323004670	Malic enzyme, N-terminal domain; Region: malic; pfam00390
657323004671	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
657323004672	putative NAD(P) binding site [chemical binding]; other site
657323004673	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
657323004674	Transcriptional regulators [Transcription]; Region: FadR; COG2186
657323004675	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657323004676	DNA-binding site [nucleotide binding]; DNA binding site
657323004677	FCD domain; Region: FCD; pfam07729
657323004678	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323004679	Walker A motif; other site
657323004680	ATP binding site [chemical binding]; other site
657323004681	Walker B motif; other site
657323004682	arginine finger; other site
657323004683	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
657323004684	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
657323004685	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
657323004686	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
657323004687	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
657323004688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323004689	dimer interface [polypeptide binding]; other site
657323004690	conserved gate region; other site
657323004691	putative PBP binding loops; other site
657323004692	ABC-ATPase subunit interface; other site
657323004693	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323004694	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323004695	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323004696	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323004697	N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755
657323004698	catalytic domain interface [polypeptide binding]; other site
657323004699	putative homodimer interface [polypeptide binding]; other site
657323004700	Protein of unknown function, DUF608; Region: DUF608; pfam04685
657323004701	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323004702	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
657323004703	Beta-lactamase; Region: Beta-lactamase; pfam00144
657323004704	Amino acid permease; Region: AA_permease_2; pfam13520
657323004705	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
657323004706	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
657323004707	active site
657323004708	metal binding site [ion binding]; metal-binding site
657323004709	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
657323004710	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
657323004711	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
657323004712	putative substrate binding site [chemical binding]; other site
657323004713	putative ATP binding site [chemical binding]; other site
657323004714	GntP family permease; Region: GntP_permease; pfam02447
657323004715	fructuronate transporter; Provisional; Region: PRK10034; cl15264
657323004716	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
657323004717	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
657323004718	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
657323004719	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
657323004720	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
657323004721	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
657323004722	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
657323004723	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
657323004724	Sugar specificity; other site
657323004725	Pyrimidine base specificity; other site
657323004726	ATP-binding site [chemical binding]; other site
657323004727	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
657323004728	FAD binding site [chemical binding]; other site
657323004729	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
657323004730	Protein of unknown function (DUF2614); Region: DUF2614; cl07936
657323004731	transcriptional regulator FimZ; Provisional; Region: PRK09935
657323004732	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323004733	active site
657323004734	phosphorylation site [posttranslational modification]
657323004735	intermolecular recognition site; other site
657323004736	dimerization interface [polypeptide binding]; other site
657323004737	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
657323004738	DNA binding residues [nucleotide binding]
657323004739	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
657323004740	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
657323004741	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
657323004742	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657323004743	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657323004744	catalytic residues [active]
657323004745	catalytic nucleophile [active]
657323004746	Recombinase; Region: Recombinase; pfam07508
657323004747	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657323004748	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
657323004749	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657323004750	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
657323004751	catalytic residues [active]
657323004752	catalytic nucleophile [active]
657323004753	Recombinase; Region: Recombinase; pfam07508
657323004754	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
657323004755	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323004756	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657323004757	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
657323004758	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
657323004759	active site
657323004760	catalytic residues [active]
657323004761	Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068
657323004762	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323004763	FeS/SAM binding site; other site
657323004764	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323004765	Walker A/P-loop; other site
657323004766	ATP binding site [chemical binding]; other site
657323004767	ABC transporter; Region: ABC_tran; pfam00005
657323004768	Q-loop/lid; other site
657323004769	ABC transporter signature motif; other site
657323004770	Walker B; other site
657323004771	D-loop; other site
657323004772	H-loop/switch region; other site
657323004773	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
657323004774	Mg binding site [ion binding]; other site
657323004775	nucleotide binding site [chemical binding]; other site
657323004776	putative protofilament interface [polypeptide binding]; other site
657323004777	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
657323004778	hypothetical protein; Validated; Region: PRK08116
657323004779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323004780	Walker A motif; other site
657323004781	ATP binding site [chemical binding]; other site
657323004782	Walker B motif; other site
657323004783	arginine finger; other site
657323004784	MobA/MobL family; Region: MobA_MobL; pfam03389
657323004785	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657323004786	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
657323004787	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
657323004788	active site
657323004789	catalytic residues [active]
657323004790	Carbon starvation protein CstA; Region: CstA; pfam02554
657323004791	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
657323004792	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
657323004793	Carbon starvation protein CstA; Region: CstA; pfam02554
657323004794	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
657323004795	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
657323004796	putative FMN binding site [chemical binding]; other site
657323004797	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
657323004798	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
657323004799	putative NAD(P) binding site [chemical binding]; other site
657323004800	catalytic Zn binding site [ion binding]; other site
657323004801	structural Zn binding site [ion binding]; other site
657323004802	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
657323004803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323004804	S-adenosylmethionine binding site [chemical binding]; other site
657323004805	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
657323004806	dimer interface [polypeptide binding]; other site
657323004807	ADP-ribose binding site [chemical binding]; other site
657323004808	active site
657323004809	nudix motif; other site
657323004810	metal binding site [ion binding]; metal-binding site
657323004811	Predicted membrane protein [Function unknown]; Region: COG3601
657323004812	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
657323004813	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323004814	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
657323004815	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
657323004816	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
657323004817	Sodium Bile acid symporter family; Region: SBF; pfam01758
657323004818	Pantoate-beta-alanine ligase; Region: PanC; cd00560
657323004819	pantoate--beta-alanine ligase; Region: panC; TIGR00018
657323004820	active site
657323004821	ATP-binding site [chemical binding]; other site
657323004822	pantoate-binding site; other site
657323004823	HXXH motif; other site
657323004824	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
657323004825	tetramerization interface [polypeptide binding]; other site
657323004826	active site
657323004827	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
657323004828	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
657323004829	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
657323004830	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
657323004831	RNA binding site [nucleotide binding]; other site
657323004832	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
657323004833	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
657323004834	NAD(P) binding site [chemical binding]; other site
657323004835	LDH/MDH dimer interface [polypeptide binding]; other site
657323004836	substrate binding site [chemical binding]; other site
657323004837	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
657323004838	ApbE family; Region: ApbE; pfam02424
657323004839	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
657323004840	4Fe-4S binding domain; Region: Fer4_5; pfam12801
657323004841	FMN-binding domain; Region: FMN_bind; cl01081
657323004842	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
657323004843	Protein of unknown function (DUF975); Region: DUF975; cl10504
657323004844	aspartate kinase; Reviewed; Region: PRK06635
657323004845	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
657323004846	putative nucleotide binding site [chemical binding]; other site
657323004847	putative catalytic residues [active]
657323004848	putative Mg ion binding site [ion binding]; other site
657323004849	putative aspartate binding site [chemical binding]; other site
657323004850	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
657323004851	putative allosteric regulatory site; other site
657323004852	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
657323004853	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
657323004854	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
657323004855	peptide chain release factor 2; Provisional; Region: PRK05589
657323004856	PCRF domain; Region: PCRF; pfam03462
657323004857	RF-1 domain; Region: RF-1; pfam00472
657323004858	Predicted amidohydrolase [General function prediction only]; Region: COG0388
657323004859	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
657323004860	putative active site [active]
657323004861	catalytic triad [active]
657323004862	dimer interface [polypeptide binding]; other site
657323004863	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
657323004864	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
657323004865	ATP binding site [chemical binding]; other site
657323004866	putative Mg++ binding site [ion binding]; other site
657323004867	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
657323004868	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
657323004869	nucleotide binding region [chemical binding]; other site
657323004870	ATP-binding site [chemical binding]; other site
657323004871	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837
657323004872	SEC-C motif; Region: SEC-C; pfam02810
657323004873	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
657323004874	30S subunit binding site; other site
657323004875	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
657323004876	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
657323004877	active site
657323004878	dihydrodipicolinate reductase; Provisional; Region: PRK00048
657323004879	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
657323004880	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
657323004881	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
657323004882	dihydrodipicolinate synthase; Region: dapA; TIGR00674
657323004883	dimer interface [polypeptide binding]; other site
657323004884	active site
657323004885	catalytic residue [active]
657323004886	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657323004887	Walker A motif; other site
657323004888	ATP binding site [chemical binding]; other site
657323004889	Walker B motif; other site
657323004890	single-stranded DNA-binding protein; Provisional; Region: PRK05813
657323004891	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
657323004892	dimer interface [polypeptide binding]; other site
657323004893	ssDNA binding site [nucleotide binding]; other site
657323004894	tetramer (dimer of dimers) interface [polypeptide binding]; other site
657323004895	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
657323004896	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
657323004897	G1 box; other site
657323004898	putative GEF interaction site [polypeptide binding]; other site
657323004899	GTP/Mg2+ binding site [chemical binding]; other site
657323004900	Switch I region; other site
657323004901	G2 box; other site
657323004902	G3 box; other site
657323004903	Switch II region; other site
657323004904	G4 box; other site
657323004905	G5 box; other site
657323004906	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
657323004907	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
657323004908	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
657323004909	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
657323004910	putative catalytic cysteine [active]
657323004911	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
657323004912	putative active site [active]
657323004913	metal binding site [ion binding]; metal-binding site
657323004914	aspartate aminotransferase; Provisional; Region: PRK06836
657323004915	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657323004916	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323004917	homodimer interface [polypeptide binding]; other site
657323004918	catalytic residue [active]
657323004919	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
657323004920	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
657323004921	active site
657323004922	V-type ATP synthase subunit B; Provisional; Region: PRK04196
657323004923	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
657323004924	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
657323004925	Walker A motif homologous position; other site
657323004926	Walker B motif; other site
657323004927	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
657323004928	V-type ATP synthase subunit A; Provisional; Region: PRK04192
657323004929	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
657323004930	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
657323004931	Walker A motif/ATP binding site; other site
657323004932	Walker B motif; other site
657323004933	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
657323004934	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632
657323004935	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
657323004936	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
657323004937	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
657323004938	V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074
657323004939	V-type ATP synthase subunit K; Validated; Region: PRK06558
657323004940	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
657323004941	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
657323004942	V-type ATP synthase subunit I; Validated; Region: PRK05771
657323004943	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657323004944	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657323004945	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
657323004946	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
657323004947	active site
657323004948	putative hydratase; Provisional; Region: PRK11413
657323004949	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
657323004950	substrate binding site [chemical binding]; other site
657323004951	ligand binding site [chemical binding]; other site
657323004952	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
657323004953	substrate binding site [chemical binding]; other site
657323004954	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
657323004955	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
657323004956	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
657323004957	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
657323004958	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
657323004959	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
657323004960	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
657323004961	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
657323004962	ATP-grasp domain; Region: ATP-grasp_4; cl17255
657323004963	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
657323004964	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
657323004965	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
657323004966	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
657323004967	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657323004968	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657323004969	catalytic residue [active]
657323004970	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323004971	xanthine permease; Region: pbuX; TIGR03173
657323004972	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323004973	4Fe-4S single cluster domain; Region: Fer4_14; pfam13394
657323004974	FeS/SAM binding site; other site
657323004975	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
657323004976	Short repeat of unknown function (DUF308); Region: DUF308; pfam03729
657323004977	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
657323004978	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
657323004979	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
657323004980	Domain of unknown function DUF21; Region: DUF21; pfam01595
657323004981	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
657323004982	Transporter associated domain; Region: CorC_HlyC; pfam03471
657323004983	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
657323004984	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323004985	dimer interface [polypeptide binding]; other site
657323004986	phosphorylation site [posttranslational modification]
657323004987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323004988	ATP binding site [chemical binding]; other site
657323004989	Mg2+ binding site [ion binding]; other site
657323004990	G-X-G motif; other site
657323004991	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
657323004992	PhoU domain; Region: PhoU; pfam01895
657323004993	PhoU domain; Region: PhoU; pfam01895
657323004994	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
657323004995	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
657323004996	Walker A/P-loop; other site
657323004997	ATP binding site [chemical binding]; other site
657323004998	Q-loop/lid; other site
657323004999	ABC transporter signature motif; other site
657323005000	Walker B; other site
657323005001	D-loop; other site
657323005002	H-loop/switch region; other site
657323005003	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323005004	putative PBP binding loops; other site
657323005005	ABC-ATPase subunit interface; other site
657323005006	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
657323005007	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
657323005008	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323005009	dimer interface [polypeptide binding]; other site
657323005010	conserved gate region; other site
657323005011	putative PBP binding loops; other site
657323005012	ABC-ATPase subunit interface; other site
657323005013	PBP superfamily domain; Region: PBP_like_2; cl17296
657323005014	PBP superfamily domain; Region: PBP_like_2; cl17296
657323005015	Transcriptional regulator; Region: Rrf2; cl17282
657323005016	Rrf2 family protein; Region: rrf2_super; TIGR00738
657323005017	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
657323005018	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
657323005019	dimer interface [polypeptide binding]; other site
657323005020	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323005021	catalytic residue [active]
657323005022	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
657323005023	Predicted membrane protein [Function unknown]; Region: COG4709
657323005024	Predicted transcriptional regulators [Transcription]; Region: COG1695
657323005025	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
657323005026	Transcriptional activator; Region: Transcrip_act; pfam04949
657323005027	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
657323005028	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
657323005029	active site
657323005030	metal binding site [ion binding]; metal-binding site
657323005031	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
657323005032	active site
657323005033	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
657323005034	Catalytic domain of Protein Kinases; Region: PKc; cd00180
657323005035	active site
657323005036	ATP binding site [chemical binding]; other site
657323005037	substrate binding site [chemical binding]; other site
657323005038	activation loop (A-loop); other site
657323005039	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
657323005040	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
657323005041	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
657323005042	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
657323005043	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
657323005044	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
657323005045	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
657323005046	G-loop; other site
657323005047	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
657323005048	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
657323005049	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
657323005050	DNA binding site [nucleotide binding]
657323005051	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
657323005052	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
657323005053	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
657323005054	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
657323005055	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
657323005056	RPB1 interaction site [polypeptide binding]; other site
657323005057	RPB10 interaction site [polypeptide binding]; other site
657323005058	RPB11 interaction site [polypeptide binding]; other site
657323005059	RPB3 interaction site [polypeptide binding]; other site
657323005060	RPB12 interaction site [polypeptide binding]; other site
657323005061	Right handed beta helix region; Region: Beta_helix; pfam13229
657323005062	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
657323005063	core dimer interface [polypeptide binding]; other site
657323005064	peripheral dimer interface [polypeptide binding]; other site
657323005065	L10 interface [polypeptide binding]; other site
657323005066	L11 interface [polypeptide binding]; other site
657323005067	putative EF-Tu interaction site [polypeptide binding]; other site
657323005068	putative EF-G interaction site [polypeptide binding]; other site
657323005069	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
657323005070	23S rRNA interface [nucleotide binding]; other site
657323005071	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
657323005072	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657323005073	active site
657323005074	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323005075	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
657323005076	active site
657323005077	motif I; other site
657323005078	motif II; other site
657323005079	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
657323005080	ApbE family; Region: ApbE; pfam02424
657323005081	ApbE family; Region: ApbE; pfam02424
657323005082	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
657323005083	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
657323005084	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
657323005085	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657323005086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323005087	dimer interface [polypeptide binding]; other site
657323005088	conserved gate region; other site
657323005089	putative PBP binding loops; other site
657323005090	ABC-ATPase subunit interface; other site
657323005091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323005092	dimer interface [polypeptide binding]; other site
657323005093	conserved gate region; other site
657323005094	putative PBP binding loops; other site
657323005095	ABC-ATPase subunit interface; other site
657323005096	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323005097	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323005098	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
657323005099	Histidine kinase; Region: His_kinase; pfam06580
657323005100	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323005101	ATP binding site [chemical binding]; other site
657323005102	Mg2+ binding site [ion binding]; other site
657323005103	G-X-G motif; other site
657323005104	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323005105	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323005106	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
657323005107	Na2 binding site [ion binding]; other site
657323005108	putative substrate binding site 1 [chemical binding]; other site
657323005109	Na binding site 1 [ion binding]; other site
657323005110	putative substrate binding site 2 [chemical binding]; other site
657323005111	SWIM zinc finger; Region: SWIM; pfam04434
657323005112	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
657323005113	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
657323005114	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
657323005115	ATP binding site [chemical binding]; other site
657323005116	putative Mg++ binding site [ion binding]; other site
657323005117	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
657323005118	nucleotide binding region [chemical binding]; other site
657323005119	ATP-binding site [chemical binding]; other site
657323005120	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
657323005121	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
657323005122	putative DNA binding site [nucleotide binding]; other site
657323005123	putative Zn2+ binding site [ion binding]; other site
657323005124	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
657323005125	thiamine phosphate binding site [chemical binding]; other site
657323005126	active site
657323005127	pyrophosphate binding site [ion binding]; other site
657323005128	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
657323005129	multimerization interface [polypeptide binding]; other site
657323005130	ATP binding site [chemical binding]; other site
657323005131	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
657323005132	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
657323005133	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
657323005134	active site
657323005135	catalytic tetrad [active]
657323005136	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
657323005137	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
657323005138	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657323005139	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323005140	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
657323005141	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
657323005142	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
657323005143	dinuclear metal binding motif [ion binding]; other site
657323005144	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
657323005145	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
657323005146	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
657323005147	Uncharacterized conserved protein [Function unknown]; Region: COG1284
657323005148	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
657323005149	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
657323005150	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
657323005151	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
657323005152	ArsC family; Region: ArsC; pfam03960
657323005153	putative ArsC-like catalytic residues; other site
657323005154	putative TRX-like catalytic residues [active]
657323005155	Putative zinc-finger; Region: zf-HC2; pfam13490
657323005156	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
657323005157	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657323005158	GAF domain; Region: GAF; cl17456
657323005159	GAF domain; Region: GAF_2; pfam13185
657323005160	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657323005161	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657323005162	metal binding site [ion binding]; metal-binding site
657323005163	active site
657323005164	I-site; other site
657323005165	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
657323005166	beta-galactosidase; Region: BGL; TIGR03356
657323005167	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
657323005168	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
657323005169	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
657323005170	active site turn [active]
657323005171	phosphorylation site [posttranslational modification]
657323005172	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
657323005173	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
657323005174	HPr interaction site; other site
657323005175	glycerol kinase (GK) interaction site [polypeptide binding]; other site
657323005176	active site
657323005177	phosphorylation site [posttranslational modification]
657323005178	transcriptional antiterminator BglG; Provisional; Region: PRK09772
657323005179	CAT RNA binding domain; Region: CAT_RBD; smart01061
657323005180	PRD domain; Region: PRD; pfam00874
657323005181	PRD domain; Region: PRD; pfam00874
657323005182	Uncharacterized membrane protein [Function unknown]; Region: COG3949
657323005183	FAD binding domain; Region: FAD_binding_4; pfam01565
657323005184	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
657323005185	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
657323005186	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
657323005187	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
657323005188	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
657323005189	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
657323005190	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
657323005191	Ligand binding site [chemical binding]; other site
657323005192	Electron transfer flavoprotein domain; Region: ETF; pfam01012
657323005193	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
657323005194	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
657323005195	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
657323005196	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
657323005197	Walker A/P-loop; other site
657323005198	ATP binding site [chemical binding]; other site
657323005199	Q-loop/lid; other site
657323005200	ABC transporter signature motif; other site
657323005201	Walker B; other site
657323005202	D-loop; other site
657323005203	H-loop/switch region; other site
657323005204	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323005205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323005206	dimer interface [polypeptide binding]; other site
657323005207	phosphorylation site [posttranslational modification]
657323005208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323005209	ATP binding site [chemical binding]; other site
657323005210	Mg2+ binding site [ion binding]; other site
657323005211	G-X-G motif; other site
657323005212	VanZ like family; Region: VanZ; pfam04892
657323005213	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323005214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323005215	active site
657323005216	phosphorylation site [posttranslational modification]
657323005217	intermolecular recognition site; other site
657323005218	dimerization interface [polypeptide binding]; other site
657323005219	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323005220	DNA binding site [nucleotide binding]
657323005221	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
657323005222	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
657323005223	Methyltransferase domain; Region: Methyltransf_31; pfam13847
657323005224	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323005225	S-adenosylmethionine binding site [chemical binding]; other site
657323005226	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
657323005227	elongation factor Tu; Reviewed; Region: PRK00049
657323005228	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
657323005229	G1 box; other site
657323005230	GEF interaction site [polypeptide binding]; other site
657323005231	GTP/Mg2+ binding site [chemical binding]; other site
657323005232	Switch I region; other site
657323005233	G2 box; other site
657323005234	G3 box; other site
657323005235	Switch II region; other site
657323005236	G4 box; other site
657323005237	G5 box; other site
657323005238	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
657323005239	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
657323005240	Antibiotic Binding Site [chemical binding]; other site
657323005241	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
657323005242	S17 interaction site [polypeptide binding]; other site
657323005243	S8 interaction site; other site
657323005244	16S rRNA interaction site [nucleotide binding]; other site
657323005245	streptomycin interaction site [chemical binding]; other site
657323005246	23S rRNA interaction site [nucleotide binding]; other site
657323005247	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
657323005248	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
657323005249	Protein of unknown function (DUF1307); Region: DUF1307; cl01981
657323005250	ACT domain-containing protein [General function prediction only]; Region: COG4747
657323005251	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
657323005252	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
657323005253	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
657323005254	Predicted membrane protein [Function unknown]; Region: COG2119
657323005255	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
657323005256	Repair protein; Region: Repair_PSII; pfam04536
657323005257	LemA family; Region: LemA; cl00742
657323005258	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
657323005259	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
657323005260	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
657323005261	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
657323005262	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657323005263	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323005264	homodimer interface [polypeptide binding]; other site
657323005265	catalytic residue [active]
657323005266	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
657323005267	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
657323005268	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
657323005269	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
657323005270	CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895
657323005271	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
657323005272	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
657323005273	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
657323005274	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754
657323005275	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
657323005276	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
657323005277	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
657323005278	MOSC domain; Region: MOSC; pfam03473
657323005279	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
657323005280	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
657323005281	active site
657323005282	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
657323005283	MPT binding site; other site
657323005284	trimer interface [polypeptide binding]; other site
657323005285	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
657323005286	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323005287	FeS/SAM binding site; other site
657323005288	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
657323005289	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
657323005290	trimer interface [polypeptide binding]; other site
657323005291	dimer interface [polypeptide binding]; other site
657323005292	putative active site [active]
657323005293	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
657323005294	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
657323005295	active site
657323005296	HIGH motif; other site
657323005297	KMSKS motif; other site
657323005298	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
657323005299	tRNA binding surface [nucleotide binding]; other site
657323005300	anticodon binding site; other site
657323005301	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
657323005302	dimer interface [polypeptide binding]; other site
657323005303	putative tRNA-binding site [nucleotide binding]; other site
657323005304	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
657323005305	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
657323005306	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
657323005307	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
657323005308	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
657323005309	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
657323005310	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
657323005311	metal binding site 2 [ion binding]; metal-binding site
657323005312	putative DNA binding helix; other site
657323005313	metal binding site 1 [ion binding]; metal-binding site
657323005314	dimer interface [polypeptide binding]; other site
657323005315	structural Zn2+ binding site [ion binding]; other site
657323005316	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
657323005317	Rubredoxin; Region: Rubredoxin; pfam00301
657323005318	iron binding site [ion binding]; other site
657323005319	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
657323005320	Rubrerythrin [Energy production and conversion]; Region: COG1592
657323005321	diiron binding motif [ion binding]; other site
657323005322	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
657323005323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
657323005324	HD domain; Region: HD_3; pfam13023
657323005325	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657323005326	Zn2+ binding site [ion binding]; other site
657323005327	Mg2+ binding site [ion binding]; other site
657323005328	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
657323005329	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
657323005330	active site pocket [active]
657323005331	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
657323005332	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
657323005333	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
657323005334	active site
657323005335	catalytic site [active]
657323005336	substrate binding site [chemical binding]; other site
657323005337	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
657323005338	active site
657323005339	tetramer interface [polypeptide binding]; other site
657323005340	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
657323005341	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
657323005342	putative dimer interface [polypeptide binding]; other site
657323005343	Predicted permease; Region: DUF318; cl17795
657323005344	YibE/F-like protein; Region: YibE_F; pfam07907
657323005345	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
657323005346	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
657323005347	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
657323005348	active site turn [active]
657323005349	phosphorylation site [posttranslational modification]
657323005350	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
657323005351	HPr interaction site; other site
657323005352	glycerol kinase (GK) interaction site [polypeptide binding]; other site
657323005353	active site
657323005354	phosphorylation site [posttranslational modification]
657323005355	DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033
657323005356	DNA binding site [nucleotide binding]
657323005357	T surface-antigen of pili; Region: FctA; cl16948
657323005358	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
657323005359	active site
657323005360	catalytic site [active]
657323005361	T surface-antigen of pili; Region: FctA; pfam12892
657323005362	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
657323005363	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
657323005364	Catalytic site [active]
657323005365	Surface antigen [General function prediction only]; Region: COG3942
657323005366	CHAP domain; Region: CHAP; cl17642
657323005367	Predicted membrane protein [Function unknown]; Region: COG2364
657323005368	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
657323005369	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
657323005370	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
657323005371	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
657323005372	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
657323005373	transmembrane helices; other site
657323005374	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323005375	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323005376	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657323005377	dimerization interface [polypeptide binding]; other site
657323005378	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
657323005379	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
657323005380	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
657323005381	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
657323005382	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
657323005383	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
657323005384	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
657323005385	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
657323005386	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
657323005387	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
657323005388	protein binding site [polypeptide binding]; other site
657323005389	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
657323005390	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
657323005391	ABC-ATPase subunit  interface; other site
657323005392	dimer interface [polypeptide binding]; other site
657323005393	putative PBP binding regions; other site
657323005394	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
657323005395	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
657323005396	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
657323005397	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
657323005398	metal binding site [ion binding]; metal-binding site
657323005399	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
657323005400	metal binding site 2 [ion binding]; metal-binding site
657323005401	putative DNA binding helix; other site
657323005402	metal binding site 1 [ion binding]; metal-binding site
657323005403	dimer interface [polypeptide binding]; other site
657323005404	structural Zn2+ binding site [ion binding]; other site
657323005405	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
657323005406	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
657323005407	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
657323005408	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
657323005409	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
657323005410	tetrameric interface [polypeptide binding]; other site
657323005411	NAD binding site [chemical binding]; other site
657323005412	catalytic residues [active]
657323005413	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
657323005414	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
657323005415	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657323005416	Zn2+ binding site [ion binding]; other site
657323005417	Mg2+ binding site [ion binding]; other site
657323005418	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657323005419	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657323005420	metal binding site [ion binding]; metal-binding site
657323005421	active site
657323005422	I-site; other site
657323005423	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323005424	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657323005425	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657323005426	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323005427	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
657323005428	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
657323005429	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
657323005430	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
657323005431	metal binding site [ion binding]; metal-binding site
657323005432	active site
657323005433	I-site; other site
657323005434	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
657323005435	PAS domain; Region: PAS_9; pfam13426
657323005436	putative active site [active]
657323005437	heme pocket [chemical binding]; other site
657323005438	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
657323005439	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657323005440	Coenzyme A binding pocket [chemical binding]; other site
657323005441	Cupin domain; Region: Cupin_2; pfam07883
657323005442	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
657323005443	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323005444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323005445	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
657323005446	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
657323005447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657323005448	putative substrate translocation pore; other site
657323005449	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323005450	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657323005451	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
657323005452	AAA domain; Region: AAA_30; pfam13604
657323005453	Family description; Region: UvrD_C_2; pfam13538
657323005454	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
657323005455	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
657323005456	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
657323005457	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
657323005458	intersubunit interface [polypeptide binding]; other site
657323005459	active site
657323005460	catalytic residue [active]
657323005461	phosphopentomutase; Provisional; Region: PRK05362
657323005462	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
657323005463	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
657323005464	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
657323005465	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
657323005466	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
657323005467	Helix-turn-helix domain; Region: HTH_31; pfam13560
657323005468	salt bridge; other site
657323005469	non-specific DNA binding site [nucleotide binding]; other site
657323005470	sequence-specific DNA binding site [nucleotide binding]; other site
657323005471	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552
657323005472	YolD-like protein; Region: YolD; pfam08863
657323005473	DNA polymerase IV; Reviewed; Region: PRK03103
657323005474	Y-family of DNA polymerases; Region: PolY; cl12025
657323005475	active site
657323005476	DNA binding site [nucleotide binding]
657323005477	hypothetical protein; Validated; Region: PRK00124
657323005478	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
657323005479	active site
657323005480	metal binding site [ion binding]; metal-binding site
657323005481	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
657323005482	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
657323005483	active site
657323005484	catalytic residues [active]
657323005485	metal binding site [ion binding]; metal-binding site
657323005486	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
657323005487	maltose O-acetyltransferase; Provisional; Region: PRK10092
657323005488	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
657323005489	active site
657323005490	substrate binding site [chemical binding]; other site
657323005491	trimer interface [polypeptide binding]; other site
657323005492	CoA binding site [chemical binding]; other site
657323005493	AAA domain; Region: AAA_14; pfam13173
657323005494	hypothetical protein; Provisional; Region: PRK11770
657323005495	Domain of unknown function (DUF307); Region: DUF307; pfam03733
657323005496	Domain of unknown function (DUF307); Region: DUF307; pfam03733
657323005497	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
657323005498	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
657323005499	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
657323005500	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
657323005501	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
657323005502	Helix-turn-helix domain; Region: HTH_28; pfam13518
657323005503	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
657323005504	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323005505	FeS/SAM binding site; other site
657323005506	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
657323005507	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
657323005508	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
657323005509	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
657323005510	acyl-activating enzyme (AAE) consensus motif; other site
657323005511	active site
657323005512	AMP binding site [chemical binding]; other site
657323005513	CoA binding site [chemical binding]; other site
657323005514	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323005515	Radical SAM superfamily; Region: Radical_SAM; pfam04055
657323005516	FeS/SAM binding site; other site
657323005517	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
657323005518	Methyltransferase domain; Region: Methyltransf_23; pfam13489
657323005519	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323005520	S-adenosylmethionine binding site [chemical binding]; other site
657323005521	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
657323005522	Cysteine-rich domain; Region: CCG; pfam02754
657323005523	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
657323005524	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
657323005525	catalytic loop [active]
657323005526	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
657323005527	iron binding site [ion binding]; other site
657323005528	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
657323005529	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
657323005530	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
657323005531	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
657323005532	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
657323005533	Ligand binding site; other site
657323005534	metal-binding site
657323005535	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
657323005536	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
657323005537	catalytic core [active]
657323005538	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
657323005539	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
657323005540	The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; Region: Luminal_IRE1_like; cl14874
657323005541	XdhC Rossmann domain; Region: XdhC_C; pfam13478
657323005542	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
657323005543	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
657323005544	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
657323005545	MPT binding site; other site
657323005546	trimer interface [polypeptide binding]; other site
657323005547	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
657323005548	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323005549	FeS/SAM binding site; other site
657323005550	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
657323005551	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
657323005552	putative active site [active]
657323005553	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
657323005554	trimer interface [polypeptide binding]; other site
657323005555	dimer interface [polypeptide binding]; other site
657323005556	MOSC domain; Region: MOSC; pfam03473
657323005557	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
657323005558	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
657323005559	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
657323005560	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
657323005561	Probable transposase; Region: OrfB_IS605; pfam01385
657323005562	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
657323005563	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
657323005564	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
657323005565	PLD-like domain; Region: PLDc_2; pfam13091
657323005566	putative active site [active]
657323005567	catalytic site [active]
657323005568	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
657323005569	PLD-like domain; Region: PLDc_2; pfam13091
657323005570	putative active site [active]
657323005571	catalytic site [active]
657323005572	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
657323005573	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
657323005574	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
657323005575	putative active site [active]
657323005576	catalytic site [active]
657323005577	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
657323005578	putative active site [active]
657323005579	catalytic site [active]
657323005580	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
657323005581	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
657323005582	synthetase active site [active]
657323005583	NTP binding site [chemical binding]; other site
657323005584	metal binding site [ion binding]; metal-binding site
657323005585	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
657323005586	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
657323005587	active site
657323005588	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
657323005589	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
657323005590	active site
657323005591	catalytic tetrad [active]
657323005592	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
657323005593	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
657323005594	flavodoxin; Provisional; Region: PRK07116
657323005595	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323005596	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323005597	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657323005598	dimerization interface [polypeptide binding]; other site
657323005599	Low molecular weight phosphatase family; Region: LMWPc; cl00105
657323005600	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
657323005601	active site
657323005602	Sodium Bile acid symporter family; Region: SBF; cl17470
657323005603	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
657323005604	Sodium Bile acid symporter family; Region: SBF; cl17470
657323005605	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
657323005606	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
657323005607	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
657323005608	leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113
657323005609	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
657323005610	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
657323005611	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657323005612	Magnesium ion binding site [ion binding]; other site
657323005613	ParB-like nuclease domain; Region: ParBc; pfam02195
657323005614	seryl-tRNA synthetase; Provisional; Region: PRK05431
657323005615	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
657323005616	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
657323005617	motif 1; other site
657323005618	dimer interface [polypeptide binding]; other site
657323005619	active site
657323005620	motif 2; other site
657323005621	motif 3; other site
657323005622	ParB-like nuclease domain; Region: ParB; smart00470
657323005623	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
657323005624	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
657323005625	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657323005626	P-loop; other site
657323005627	Magnesium ion binding site [ion binding]; other site
657323005628	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657323005629	Magnesium ion binding site [ion binding]; other site
657323005630	hydrolase, alpha/beta fold family protein; Region: PLN02824
657323005631	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
657323005632	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
657323005633	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
657323005634	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
657323005635	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
657323005636	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
657323005637	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
657323005638	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
657323005639	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
657323005640	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
657323005641	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
657323005642	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
657323005643	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
657323005644	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
657323005645	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
657323005646	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
657323005647	trmE is a tRNA modification GTPase; Region: trmE; cd04164
657323005648	G1 box; other site
657323005649	GTP/Mg2+ binding site [chemical binding]; other site
657323005650	Switch I region; other site
657323005651	G2 box; other site
657323005652	Switch II region; other site
657323005653	G3 box; other site
657323005654	G4 box; other site
657323005655	G5 box; other site
657323005656	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
657323005657	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
657323005658	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
657323005659	G-X-X-G motif; other site
657323005660	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
657323005661	RxxxH motif; other site
657323005662	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
657323005663	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
657323005664	Haemolytic domain; Region: Haemolytic; pfam01809
657323005665	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
657323005666	DnaA N-terminal domain; Region: DnaA_N; pfam11638
657323005667	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
657323005668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323005669	Walker A motif; other site
657323005670	ATP binding site [chemical binding]; other site
657323005671	Walker B motif; other site
657323005672	arginine finger; other site
657323005673	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
657323005674	DnaA box-binding interface [nucleotide binding]; other site
657323005675	DNA polymerase III subunit beta; Validated; Region: PRK05643
657323005676	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
657323005677	putative DNA binding surface [nucleotide binding]; other site
657323005678	dimer interface [polypeptide binding]; other site
657323005679	beta-clamp/clamp loader binding surface; other site
657323005680	beta-clamp/translesion DNA polymerase binding surface; other site
657323005681	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323005682	Walker A/P-loop; other site
657323005683	ATP binding site [chemical binding]; other site
657323005684	Q-loop/lid; other site
657323005685	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
657323005686	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
657323005687	Predicted secreted protein [Function unknown]; Region: COG4086
657323005688	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
657323005689	RNA binding site [nucleotide binding]; other site
657323005690	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
657323005691	RNA binding site [nucleotide binding]; other site
657323005692	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
657323005693	RNA binding site [nucleotide binding]; other site
657323005694	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
657323005695	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
657323005696	DRTGG domain; Region: DRTGG; pfam07085
657323005697	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
657323005698	DHH family; Region: DHH; pfam01368
657323005699	DHHA2 domain; Region: DHHA2; pfam02833
657323005700	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
657323005701	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
657323005702	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
657323005703	hinge; other site
657323005704	active site
657323005705	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
657323005706	Bacterial SH3 domain; Region: SH3_3; cl17532
657323005707	PA14 domain; Region: PA14; cl08459
657323005708	Cna protein B-type domain; Region: Cna_B; pfam05738
657323005709	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
657323005710	metal ion-dependent adhesion site (MIDAS); other site
657323005711	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
657323005712	Cna protein B-type domain; Region: Cna_B; pfam05738
657323005713	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
657323005714	active site
657323005715	catalytic site [active]
657323005716	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
657323005717	active site
657323005718	catalytic site [active]
657323005719	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
657323005720	S-adenosylmethionine synthetase; Validated; Region: PRK05250
657323005721	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
657323005722	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
657323005723	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323005724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323005725	active site
657323005726	phosphorylation site [posttranslational modification]
657323005727	intermolecular recognition site; other site
657323005728	dimerization interface [polypeptide binding]; other site
657323005729	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323005730	DNA binding site [nucleotide binding]
657323005731	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
657323005732	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657323005733	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657323005734	catalytic residue [active]
657323005735	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
657323005736	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
657323005737	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
657323005738	active site
657323005739	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
657323005740	DNA polymerase III subunit delta'; Validated; Region: PRK07132
657323005741	DNA polymerase III subunit delta'; Validated; Region: PRK08485
657323005742	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
657323005743	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
657323005744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323005745	S-adenosylmethionine binding site [chemical binding]; other site
657323005746	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
657323005747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323005748	Mg2+ binding site [ion binding]; other site
657323005749	G-X-G motif; other site
657323005750	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
657323005751	anchoring element; other site
657323005752	dimer interface [polypeptide binding]; other site
657323005753	ATP binding site [chemical binding]; other site
657323005754	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
657323005755	active site
657323005756	putative metal-binding site [ion binding]; other site
657323005757	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
657323005758	DNA gyrase subunit A; Validated; Region: PRK05560
657323005759	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
657323005760	CAP-like domain; other site
657323005761	active site
657323005762	primary dimer interface [polypeptide binding]; other site
657323005763	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657323005764	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657323005765	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657323005766	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657323005767	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
657323005768	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
657323005769	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
657323005770	putative acyl-acceptor binding pocket; other site
657323005771	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
657323005772	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
657323005773	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
657323005774	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
657323005775	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323005776	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323005777	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323005778	non-specific DNA binding site [nucleotide binding]; other site
657323005779	salt bridge; other site
657323005780	sequence-specific DNA binding site [nucleotide binding]; other site
657323005781	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323005782	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323005783	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323005784	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323005785	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323005786	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323005787	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
657323005788	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
657323005789	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
657323005790	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
657323005791	NTP binding site [chemical binding]; other site
657323005792	HEPN domain; Region: HEPN; pfam05168
657323005793	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657323005794	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323005795	DNA binding site [nucleotide binding]
657323005796	domain linker motif; other site
657323005797	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657323005798	ligand binding site [chemical binding]; other site
657323005799	dimerization interface [polypeptide binding]; other site
657323005800	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
657323005801	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
657323005802	substrate binding pocket [chemical binding]; other site
657323005803	membrane-bound complex binding site; other site
657323005804	hinge residues; other site
657323005805	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
657323005806	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323005807	dimer interface [polypeptide binding]; other site
657323005808	conserved gate region; other site
657323005809	putative PBP binding loops; other site
657323005810	ABC-ATPase subunit interface; other site
657323005811	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
657323005812	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323005813	Walker A/P-loop; other site
657323005814	ATP binding site [chemical binding]; other site
657323005815	Q-loop/lid; other site
657323005816	ABC transporter signature motif; other site
657323005817	Walker B; other site
657323005818	D-loop; other site
657323005819	H-loop/switch region; other site
657323005820	TOBE domain; Region: TOBE_2; pfam08402
657323005821	Beta-lactamase; Region: Beta-lactamase; pfam00144
657323005822	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
657323005823	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
657323005824	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
657323005825	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
657323005826	putative active site [active]
657323005827	Amino acid permease; Region: AA_permease_2; pfam13520
657323005828	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
657323005829	Beta-lactamase; Region: Beta-lactamase; pfam00144
657323005830	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657323005831	Interdomain contacts; other site
657323005832	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
657323005833	thiS-thiF/thiG interaction site; other site
657323005834	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
657323005835	ThiS interaction site; other site
657323005836	putative active site [active]
657323005837	tetramer interface [polypeptide binding]; other site
657323005838	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
657323005839	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
657323005840	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323005841	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323005842	Leucine rich repeat; Region: LRR_8; pfam13855
657323005843	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
657323005844	Interdomain contacts; other site
657323005845	Cytokine receptor motif; other site
657323005846	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
657323005847	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
657323005848	substrate binding pocket [chemical binding]; other site
657323005849	membrane-bound complex binding site; other site
657323005850	hinge residues; other site
657323005851	DNA cytosine methylase; Provisional; Region: PRK10458
657323005852	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323005853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323005854	active site
657323005855	phosphorylation site [posttranslational modification]
657323005856	intermolecular recognition site; other site
657323005857	dimerization interface [polypeptide binding]; other site
657323005858	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323005859	DNA binding site [nucleotide binding]
657323005860	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
657323005861	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
657323005862	4Fe-4S binding domain; Region: Fer4; cl02805
657323005863	4Fe-4S binding domain; Region: Fer4; pfam00037
657323005864	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
657323005865	CPxP  motif; other site
657323005866	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
657323005867	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
657323005868	ATP binding site [chemical binding]; other site
657323005869	substrate interface [chemical binding]; other site
657323005870	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
657323005871	L-aspartate oxidase; Provisional; Region: PRK06175
657323005872	Ferredoxin [Energy production and conversion]; Region: COG1146
657323005873	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
657323005874	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
657323005875	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
657323005876	Active Sites [active]
657323005877	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
657323005878	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
657323005879	CysD dimerization site [polypeptide binding]; other site
657323005880	G1 box; other site
657323005881	putative GEF interaction site [polypeptide binding]; other site
657323005882	GTP/Mg2+ binding site [chemical binding]; other site
657323005883	Switch I region; other site
657323005884	G2 box; other site
657323005885	G3 box; other site
657323005886	Switch II region; other site
657323005887	G4 box; other site
657323005888	G5 box; other site
657323005889	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
657323005890	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
657323005891	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
657323005892	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
657323005893	inhibitor-cofactor binding pocket; inhibition site
657323005894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323005895	catalytic residue [active]
657323005896	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
657323005897	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
657323005898	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657323005899	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
657323005900	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
657323005901	TM-ABC transporter signature motif; other site
657323005902	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
657323005903	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
657323005904	TM-ABC transporter signature motif; other site
657323005905	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
657323005906	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
657323005907	Walker A/P-loop; other site
657323005908	ATP binding site [chemical binding]; other site
657323005909	Q-loop/lid; other site
657323005910	ABC transporter signature motif; other site
657323005911	Walker B; other site
657323005912	D-loop; other site
657323005913	H-loop/switch region; other site
657323005914	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
657323005915	Cache domain; Region: Cache_1; pfam02743
657323005916	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
657323005917	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657323005918	dimerization interface [polypeptide binding]; other site
657323005919	Histidine kinase; Region: His_kinase; pfam06580
657323005920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323005921	ATP binding site [chemical binding]; other site
657323005922	Mg2+ binding site [ion binding]; other site
657323005923	G-X-G motif; other site
657323005924	Response regulator receiver domain; Region: Response_reg; pfam00072
657323005925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323005926	active site
657323005927	phosphorylation site [posttranslational modification]
657323005928	intermolecular recognition site; other site
657323005929	dimerization interface [polypeptide binding]; other site
657323005930	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323005931	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323005932	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657323005933	dimerization interface [polypeptide binding]; other site
657323005934	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657323005935	ligand binding site [chemical binding]; other site
657323005936	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323005937	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657323005938	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657323005939	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323005940	DNA binding site [nucleotide binding]
657323005941	domain linker motif; other site
657323005942	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
657323005943	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
657323005944	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
657323005945	B12 binding site [chemical binding]; other site
657323005946	cobalt ligand [ion binding]; other site
657323005947	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
657323005948	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
657323005949	substrate binding pocket [chemical binding]; other site
657323005950	dimer interface [polypeptide binding]; other site
657323005951	inhibitor binding site; inhibition site
657323005952	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
657323005953	Domain of unknown function (DUF718); Region: DUF718; pfam05336
657323005954	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
657323005955	trimer interface [polypeptide binding]; other site
657323005956	putative Zn binding site [ion binding]; other site
657323005957	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
657323005958	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
657323005959	FMN binding site [chemical binding]; other site
657323005960	substrate binding site [chemical binding]; other site
657323005961	putative catalytic residue [active]
657323005962	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
657323005963	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
657323005964	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
657323005965	Ligand Binding Site [chemical binding]; other site
657323005966	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
657323005967	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323005968	FeS/SAM binding site; other site
657323005969	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
657323005970	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
657323005971	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
657323005972	substrate binding [chemical binding]; other site
657323005973	active site
657323005974	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
657323005975	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323005976	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657323005977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323005978	dimer interface [polypeptide binding]; other site
657323005979	conserved gate region; other site
657323005980	putative PBP binding loops; other site
657323005981	ABC-ATPase subunit interface; other site
657323005982	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
657323005983	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323005984	dimer interface [polypeptide binding]; other site
657323005985	conserved gate region; other site
657323005986	putative PBP binding loops; other site
657323005987	ABC-ATPase subunit interface; other site
657323005988	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657323005989	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323005990	DNA binding site [nucleotide binding]
657323005991	domain linker motif; other site
657323005992	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657323005993	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
657323005994	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
657323005995	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
657323005996	active site
657323005997	catalytic site [active]
657323005998	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
657323005999	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
657323006000	Flavodoxin domain; Region: Flavodoxin_5; cl17428
657323006001	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657323006002	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323006003	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657323006004	serine/threonine transporter SstT; Provisional; Region: PRK13628
657323006005	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
657323006006	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
657323006007	4-alpha-glucanotransferase; Provisional; Region: PRK14508
657323006008	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657323006009	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323006010	DNA binding site [nucleotide binding]
657323006011	domain linker motif; other site
657323006012	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
657323006013	putative dimerization interface [polypeptide binding]; other site
657323006014	putative ligand binding site [chemical binding]; other site
657323006015	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
657323006016	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657323006017	Coenzyme A binding pocket [chemical binding]; other site
657323006018	Peptidase family U32; Region: Peptidase_U32; cl03113
657323006019	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
657323006020	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
657323006021	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
657323006022	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
657323006023	Methyltransferase domain; Region: Methyltransf_31; pfam13847
657323006024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323006025	S-adenosylmethionine binding site [chemical binding]; other site
657323006026	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
657323006027	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323006028	S-adenosylmethionine binding site [chemical binding]; other site
657323006029	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
657323006030	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
657323006031	substrate binding site [chemical binding]; other site
657323006032	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
657323006033	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
657323006034	Walker A/P-loop; other site
657323006035	ATP binding site [chemical binding]; other site
657323006036	Q-loop/lid; other site
657323006037	ABC transporter signature motif; other site
657323006038	Walker B; other site
657323006039	D-loop; other site
657323006040	H-loop/switch region; other site
657323006041	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
657323006042	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323006043	ABC-ATPase subunit interface; other site
657323006044	putative PBP binding loops; other site
657323006045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323006046	dimer interface [polypeptide binding]; other site
657323006047	conserved gate region; other site
657323006048	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
657323006049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323006050	dimer interface [polypeptide binding]; other site
657323006051	conserved gate region; other site
657323006052	putative PBP binding loops; other site
657323006053	ABC-ATPase subunit interface; other site
657323006054	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323006055	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657323006056	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
657323006057	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
657323006058	Walker A/P-loop; other site
657323006059	ATP binding site [chemical binding]; other site
657323006060	Q-loop/lid; other site
657323006061	ABC transporter signature motif; other site
657323006062	Walker B; other site
657323006063	D-loop; other site
657323006064	H-loop/switch region; other site
657323006065	Predicted transcriptional regulators [Transcription]; Region: COG1725
657323006066	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657323006067	DNA-binding site [nucleotide binding]; DNA binding site
657323006068	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cd02153
657323006069	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
657323006070	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
657323006071	HTH domain; Region: HTH_11; cl17392
657323006072	Predicted transcriptional regulator [Transcription]; Region: COG2378
657323006073	WYL domain; Region: WYL; pfam13280
657323006074	TfoX N-terminal domain; Region: TfoX_N; pfam04993
657323006075	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
657323006076	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
657323006077	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
657323006078	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
657323006079	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
657323006080	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
657323006081	Methyltransferase domain; Region: Methyltransf_26; pfam13659
657323006082	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
657323006083	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
657323006084	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
657323006085	ATP binding site [chemical binding]; other site
657323006086	putative Mg++ binding site [ion binding]; other site
657323006087	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
657323006088	non-specific DNA binding site [nucleotide binding]; other site
657323006089	salt bridge; other site
657323006090	sequence-specific DNA binding site [nucleotide binding]; other site
657323006091	Helix-turn-helix domain; Region: HTH_17; cl17695
657323006092	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
657323006093	Transcription factor involved in TATA site selection and in elongation by RNA polymerase II [Transcription]; Region: COG5296
657323006094	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657323006095	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323006096	non-specific DNA binding site [nucleotide binding]; other site
657323006097	salt bridge; other site
657323006098	sequence-specific DNA binding site [nucleotide binding]; other site
657323006099	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
657323006100	dimer interface [polypeptide binding]; other site
657323006101	putative tRNA-binding site [nucleotide binding]; other site
657323006102	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
657323006103	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
657323006104	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
657323006105	Int/Topo IB signature motif; other site
657323006106	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
657323006107	CHC2 zinc finger; Region: zf-CHC2; cl17510
657323006108	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
657323006109	Toprim-like; Region: Toprim_2; pfam13155
657323006110	active site
657323006111	metal binding site [ion binding]; metal-binding site
657323006112	AAA domain; Region: AAA_25; pfam13481
657323006113	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657323006114	ATP binding site [chemical binding]; other site
657323006115	Walker A motif; other site
657323006116	Walker B motif; other site
657323006117	MobA/MobL family; Region: MobA_MobL; pfam03389
657323006118	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
657323006119	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
657323006120	non-specific DNA binding site [nucleotide binding]; other site
657323006121	salt bridge; other site
657323006122	sequence-specific DNA binding site [nucleotide binding]; other site
657323006123	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
657323006124	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
657323006125	dimer interface [polypeptide binding]; other site
657323006126	ssDNA binding site [nucleotide binding]; other site
657323006127	tetramer (dimer of dimers) interface [polypeptide binding]; other site
657323006128	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
657323006129	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
657323006130	Methyltransferase domain; Region: Methyltransf_26; pfam13659
657323006131	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
657323006132	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
657323006133	catalytic residues [active]
657323006134	catalytic nucleophile [active]
657323006135	Presynaptic Site I dimer interface [polypeptide binding]; other site
657323006136	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
657323006137	Synaptic Flat tetramer interface [polypeptide binding]; other site
657323006138	Synaptic Site I dimer interface [polypeptide binding]; other site
657323006139	DNA binding site [nucleotide binding]
657323006140	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
657323006141	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
657323006142	Helix-turn-helix domain; Region: HTH_17; cl17695
657323006143	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
657323006144	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
657323006145	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
657323006146	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
657323006147	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
657323006148	Ligand binding site; other site
657323006149	Putative Catalytic site; other site
657323006150	DXD motif; other site
657323006151	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
657323006152	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
657323006153	FMN binding site [chemical binding]; other site
657323006154	active site
657323006155	catalytic residues [active]
657323006156	substrate binding site [chemical binding]; other site
657323006157	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
657323006158	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
657323006159	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
657323006160	ornithine carbamoyltransferase; Validated; Region: PRK02102
657323006161	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
657323006162	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
657323006163	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
657323006164	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
657323006165	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
657323006166	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
657323006167	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
657323006168	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
657323006169	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
657323006170	TrkA-N domain; Region: TrkA_N; pfam02254
657323006171	TrkA-C domain; Region: TrkA_C; pfam02080
657323006172	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
657323006173	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
657323006174	6-phosphofructokinase; Provisional; Region: PRK03202
657323006175	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
657323006176	active site
657323006177	ADP/pyrophosphate binding site [chemical binding]; other site
657323006178	dimerization interface [polypeptide binding]; other site
657323006179	allosteric effector site; other site
657323006180	fructose-1,6-bisphosphate binding site; other site
657323006181	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
657323006182	S1 domain; Region: S1_2; pfam13509
657323006183	S1 domain; Region: S1_2; pfam13509
657323006184	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
657323006185	RNA binding site [nucleotide binding]; other site
657323006186	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
657323006187	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
657323006188	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323006189	non-specific DNA binding site [nucleotide binding]; other site
657323006190	salt bridge; other site
657323006191	sequence-specific DNA binding site [nucleotide binding]; other site
657323006192	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
657323006193	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
657323006194	intersubunit interface [polypeptide binding]; other site
657323006195	active site
657323006196	Zn2+ binding site [ion binding]; other site
657323006197	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
657323006198	active site
657323006199	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
657323006200	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
657323006201	active site
657323006202	stage V sporulation protein T; Region: spore_V_T; TIGR02851
657323006203	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
657323006204	polyphosphate kinase; Provisional; Region: PRK05443
657323006205	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
657323006206	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
657323006207	Catalytic C-terminal domain, first repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C1_unchar; cd09166
657323006208	putative domain interface [polypeptide binding]; other site
657323006209	putative active site [active]
657323006210	catalytic site [active]
657323006211	Catalytic C-terminal domain, second repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C2_unchar; cd09169
657323006212	putative domain interface [polypeptide binding]; other site
657323006213	putative active site [active]
657323006214	catalytic site [active]
657323006215	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
657323006216	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
657323006217	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
657323006218	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323006219	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
657323006220	GIY-YIG motif/motif A; other site
657323006221	putative active site [active]
657323006222	putative metal binding site [ion binding]; other site
657323006223	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
657323006224	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
657323006225	substrate binding [chemical binding]; other site
657323006226	active site
657323006227	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
657323006228	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
657323006229	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
657323006230	active site turn [active]
657323006231	phosphorylation site [posttranslational modification]
657323006232	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
657323006233	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
657323006234	HPr interaction site; other site
657323006235	glycerol kinase (GK) interaction site [polypeptide binding]; other site
657323006236	active site
657323006237	phosphorylation site [posttranslational modification]
657323006238	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657323006239	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323006240	DNA binding site [nucleotide binding]
657323006241	domain linker motif; other site
657323006242	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
657323006243	Peptidase family M23; Region: Peptidase_M23; pfam01551
657323006244	Stage II sporulation protein; Region: SpoIID; pfam08486
657323006245	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
657323006246	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
657323006247	putative active site [active]
657323006248	putative metal binding site [ion binding]; other site
657323006249	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323006250	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
657323006251	PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions; Region: PET; cl05674
657323006252	FeoA domain; Region: FeoA; cl00838
657323006253	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
657323006254	catalytic core [active]
657323006255	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
657323006256	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
657323006257	putative tRNA-binding site [nucleotide binding]; other site
657323006258	B3/4 domain; Region: B3_4; pfam03483
657323006259	tRNA synthetase B5 domain; Region: B5; pfam03484
657323006260	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
657323006261	dimer interface [polypeptide binding]; other site
657323006262	motif 1; other site
657323006263	motif 3; other site
657323006264	motif 2; other site
657323006265	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
657323006266	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
657323006267	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
657323006268	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
657323006269	dimer interface [polypeptide binding]; other site
657323006270	motif 1; other site
657323006271	active site
657323006272	motif 2; other site
657323006273	motif 3; other site
657323006274	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
657323006275	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
657323006276	Coenzyme A binding pocket [chemical binding]; other site
657323006277	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
657323006278	active site
657323006279	catalytic residues [active]
657323006280	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
657323006281	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
657323006282	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323006283	catalytic residue [active]
657323006284	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
657323006285	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
657323006286	2-isopropylmalate synthase; Validated; Region: PRK03739
657323006287	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
657323006288	active site
657323006289	catalytic residues [active]
657323006290	metal binding site [ion binding]; metal-binding site
657323006291	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
657323006292	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
657323006293	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
657323006294	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
657323006295	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
657323006296	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
657323006297	Haemagglutinin; Region: Hemagglutinin; pfam00509
657323006298	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323006299	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323006300	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657323006301	dimerization interface [polypeptide binding]; other site
657323006302	ketol-acid reductoisomerase; Provisional; Region: PRK05479
657323006303	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
657323006304	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
657323006305	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
657323006306	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
657323006307	putative valine binding site [chemical binding]; other site
657323006308	dimer interface [polypeptide binding]; other site
657323006309	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
657323006310	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
657323006311	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
657323006312	Predicted permeases [General function prediction only]; Region: COG0679
657323006313	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323006314	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
657323006315	active site
657323006316	motif I; other site
657323006317	motif II; other site
657323006318	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323006319	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
657323006320	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
657323006321	active site
657323006322	metal binding site [ion binding]; metal-binding site
657323006323	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
657323006324	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
657323006325	Stage II sporulation protein; Region: SpoIID; pfam08486
657323006326	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
657323006327	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
657323006328	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
657323006329	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
657323006330	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
657323006331	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
657323006332	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
657323006333	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
657323006334	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
657323006335	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
657323006336	catalytic residue [active]
657323006337	putative FPP diphosphate  binding site; other site
657323006338	putative FPP binding hydrophobic cleft; other site
657323006339	dimer interface [polypeptide binding]; other site
657323006340	putative IPP diphosphate binding site; other site
657323006341	ribosome recycling factor; Reviewed; Region: frr; PRK00083
657323006342	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
657323006343	hinge region; other site
657323006344	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
657323006345	putative nucleotide binding site [chemical binding]; other site
657323006346	uridine monophosphate binding site [chemical binding]; other site
657323006347	homohexameric interface [polypeptide binding]; other site
657323006348	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
657323006349	ribonuclease R; Region: RNase_R; TIGR02063
657323006350	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
657323006351	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
657323006352	RNB domain; Region: RNB; pfam00773
657323006353	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
657323006354	RNA binding site [nucleotide binding]; other site
657323006355	enolase; Provisional; Region: eno; PRK00077
657323006356	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
657323006357	dimer interface [polypeptide binding]; other site
657323006358	metal binding site [ion binding]; metal-binding site
657323006359	substrate binding pocket [chemical binding]; other site
657323006360	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
657323006361	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
657323006362	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
657323006363	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
657323006364	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
657323006365	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
657323006366	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
657323006367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
657323006368	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
657323006369	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
657323006370	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657323006371	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323006372	active site
657323006373	phosphorylation site [posttranslational modification]
657323006374	intermolecular recognition site; other site
657323006375	LytTr DNA-binding domain; Region: LytTR; smart00850
657323006376	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
657323006377	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
657323006378	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
657323006379	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
657323006380	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
657323006381	homodimer interface [polypeptide binding]; other site
657323006382	substrate-cofactor binding pocket; other site
657323006383	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323006384	catalytic residue [active]
657323006385	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
657323006386	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
657323006387	Ligand Binding Site [chemical binding]; other site
657323006388	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
657323006389	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
657323006390	Sulfate transporter family; Region: Sulfate_transp; pfam00916
657323006391	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
657323006392	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
657323006393	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323006394	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323006395	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657323006396	dimerization interface [polypeptide binding]; other site
657323006397	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323006398	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657323006399	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323006400	Walker A/P-loop; other site
657323006401	ATP binding site [chemical binding]; other site
657323006402	Q-loop/lid; other site
657323006403	ABC transporter signature motif; other site
657323006404	Walker B; other site
657323006405	D-loop; other site
657323006406	H-loop/switch region; other site
657323006407	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323006408	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657323006409	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
657323006410	Walker A/P-loop; other site
657323006411	ATP binding site [chemical binding]; other site
657323006412	Q-loop/lid; other site
657323006413	ABC transporter signature motif; other site
657323006414	Walker B; other site
657323006415	D-loop; other site
657323006416	H-loop/switch region; other site
657323006417	DNA helicase II; Region: uvrD; TIGR01075
657323006418	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
657323006419	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
657323006420	G1 box; other site
657323006421	GTP/Mg2+ binding site [chemical binding]; other site
657323006422	Switch I region; other site
657323006423	G2 box; other site
657323006424	Switch II region; other site
657323006425	G3 box; other site
657323006426	G4 box; other site
657323006427	G5 box; other site
657323006428	Maltose acetyltransferase; Region: Mac; pfam12464
657323006429	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323006430	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
657323006431	active site
657323006432	motif I; other site
657323006433	motif II; other site
657323006434	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323006435	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
657323006436	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692
657323006437	nudix motif; other site
657323006438	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323006439	DNA binding site [nucleotide binding]
657323006440	active site
657323006441	Int/Topo IB signature motif; other site
657323006442	S-adenosylmethionine synthetase; Validated; Region: PRK05250
657323006443	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
657323006444	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
657323006445	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
657323006446	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
657323006447	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
657323006448	multiple promoter invertase; Provisional; Region: mpi; PRK13413
657323006449	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
657323006450	catalytic residues [active]
657323006451	catalytic nucleophile [active]
657323006452	Presynaptic Site I dimer interface [polypeptide binding]; other site
657323006453	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
657323006454	Synaptic Flat tetramer interface [polypeptide binding]; other site
657323006455	Synaptic Site I dimer interface [polypeptide binding]; other site
657323006456	DNA binding site [nucleotide binding]
657323006457	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
657323006458	putative active site [active]
657323006459	putative metal binding site [ion binding]; other site
657323006460	Flagellin N-methylase; Region: FliB; cl00497
657323006461	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
657323006462	AAA domain; Region: AAA_14; pfam13173
657323006463	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
657323006464	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
657323006465	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
657323006466	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
657323006467	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
657323006468	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
657323006469	nucleotide binding pocket [chemical binding]; other site
657323006470	K-X-D-G motif; other site
657323006471	catalytic site [active]
657323006472	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
657323006473	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
657323006474	Dimer interface [polypeptide binding]; other site
657323006475	BRCT sequence motif; other site
657323006476	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
657323006477	Methyltransferase domain; Region: Methyltransf_26; pfam13659
657323006478	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
657323006479	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
657323006480	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
657323006481	Walker A motif; other site
657323006482	ATP binding site [chemical binding]; other site
657323006483	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
657323006484	dimer interface [polypeptide binding]; other site
657323006485	ssDNA binding site [nucleotide binding]; other site
657323006486	tetramer (dimer of dimers) interface [polypeptide binding]; other site
657323006487	cheY-homologous receiver domain; Region: REC; smart00448
657323006488	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
657323006489	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323006490	Walker A/P-loop; other site
657323006491	ATP binding site [chemical binding]; other site
657323006492	Q-loop/lid; other site
657323006493	ABC transporter signature motif; other site
657323006494	Walker B; other site
657323006495	D-loop; other site
657323006496	H-loop/switch region; other site
657323006497	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
657323006498	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
657323006499	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323006500	FeS/SAM binding site; other site
657323006501	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
657323006502	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323006503	Protein of unknown function (DUF3268); Region: DUF3268; pfam11672
657323006504	Cna protein B-type domain; Region: Cna_B; pfam05738
657323006505	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
657323006506	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
657323006507	N-acetyl-D-glucosamine binding site [chemical binding]; other site
657323006508	catalytic residue [active]
657323006509	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
657323006510	putative active site [active]
657323006511	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323006512	Walker A/P-loop; other site
657323006513	ATP binding site [chemical binding]; other site
657323006514	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323006515	ABC transporter signature motif; other site
657323006516	Walker B; other site
657323006517	D-loop; other site
657323006518	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323006519	FeS/SAM binding site; other site
657323006520	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
657323006521	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
657323006522	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
657323006523	Walker A/P-loop; other site
657323006524	ATP binding site [chemical binding]; other site
657323006525	Q-loop/lid; other site
657323006526	ABC transporter signature motif; other site
657323006527	Walker B; other site
657323006528	D-loop; other site
657323006529	H-loop/switch region; other site
657323006530	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
657323006531	AAA-like domain; Region: AAA_10; pfam12846
657323006532	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
657323006533	Walker A motif; other site
657323006534	ATP binding site [chemical binding]; other site
657323006535	Walker B motif; other site
657323006536	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323006537	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
657323006538	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323006539	Walker A/P-loop; other site
657323006540	ATP binding site [chemical binding]; other site
657323006541	Q-loop/lid; other site
657323006542	ABC transporter signature motif; other site
657323006543	Walker B; other site
657323006544	D-loop; other site
657323006545	H-loop/switch region; other site
657323006546	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
657323006547	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323006548	Radical SAM superfamily; Region: Radical_SAM; pfam04055
657323006549	FeS/SAM binding site; other site
657323006550	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323006551	Q-loop/lid; other site
657323006552	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
657323006553	B12 binding site [chemical binding]; other site
657323006554	Radical SAM superfamily; Region: Radical_SAM; pfam04055
657323006555	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
657323006556	FeS/SAM binding site; other site
657323006557	KDPG and KHG aldolase; Region: Aldolase; cl17259
657323006558	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323006559	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657323006560	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
657323006561	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
657323006562	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
657323006563	active site
657323006564	HIGH motif; other site
657323006565	nucleotide binding site [chemical binding]; other site
657323006566	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
657323006567	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
657323006568	active site
657323006569	KMSKS motif; other site
657323006570	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
657323006571	tRNA binding surface [nucleotide binding]; other site
657323006572	anticodon binding site; other site
657323006573	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
657323006574	Sulfatase; Region: Sulfatase; pfam00884
657323006575	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
657323006576	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
657323006577	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
657323006578	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
657323006579	TPR repeat; Region: TPR_11; pfam13414
657323006580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
657323006581	binding surface
657323006582	TPR motif; other site
657323006583	TPR repeat; Region: TPR_11; pfam13414
657323006584	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
657323006585	anti sigma factor interaction site; other site
657323006586	regulatory phosphorylation site [posttranslational modification]; other site
657323006587	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
657323006588	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323006589	ATP binding site [chemical binding]; other site
657323006590	Mg2+ binding site [ion binding]; other site
657323006591	G-X-G motif; other site
657323006592	RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885
657323006593	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657323006594	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
657323006595	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657323006596	DNA binding residues [nucleotide binding]
657323006597	QueT transporter; Region: QueT; pfam06177
657323006598	Leucine rich repeat; Region: LRR_8; pfam13855
657323006599	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
657323006600	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
657323006601	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
657323006602	NADP binding site [chemical binding]; other site
657323006603	active site
657323006604	putative substrate binding site [chemical binding]; other site
657323006605	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
657323006606	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
657323006607	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323006608	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323006609	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
657323006610	dimerization interface [polypeptide binding]; other site
657323006611	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
657323006612	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
657323006613	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
657323006614	4Fe-4S binding domain; Region: Fer4; cl02805
657323006615	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
657323006616	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
657323006617	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
657323006618	SpoVA protein; Region: SpoVA; pfam03862
657323006619	stage V sporulation protein AD; Provisional; Region: PRK12404
657323006620	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
657323006621	SpoVA protein; Region: SpoVA; pfam03862
657323006622	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
657323006623	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
657323006624	ATP binding site [chemical binding]; other site
657323006625	substrate interface [chemical binding]; other site
657323006626	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
657323006627	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
657323006628	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
657323006629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
657323006630	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
657323006631	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
657323006632	dimerization domain swap beta strand [polypeptide binding]; other site
657323006633	regulatory protein interface [polypeptide binding]; other site
657323006634	active site
657323006635	regulatory phosphorylation site [posttranslational modification]; other site
657323006636	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
657323006637	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
657323006638	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
657323006639	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
657323006640	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
657323006641	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
657323006642	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
657323006643	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
657323006644	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
657323006645	protein-rRNA interface [nucleotide binding]; other site
657323006646	putative translocon binding site; other site
657323006647	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
657323006648	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
657323006649	G-X-X-G motif; other site
657323006650	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
657323006651	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
657323006652	23S rRNA interface [nucleotide binding]; other site
657323006653	5S rRNA interface [nucleotide binding]; other site
657323006654	putative antibiotic binding site [chemical binding]; other site
657323006655	L25 interface [polypeptide binding]; other site
657323006656	L27 interface [polypeptide binding]; other site
657323006657	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
657323006658	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
657323006659	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
657323006660	RNA binding site [nucleotide binding]; other site
657323006661	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
657323006662	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
657323006663	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
657323006664	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
657323006665	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
657323006666	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
657323006667	5S rRNA interface [nucleotide binding]; other site
657323006668	23S rRNA interface [nucleotide binding]; other site
657323006669	L5 interface [polypeptide binding]; other site
657323006670	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
657323006671	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
657323006672	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
657323006673	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
657323006674	23S rRNA binding site [nucleotide binding]; other site
657323006675	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
657323006676	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
657323006677	SecY translocase; Region: SecY; pfam00344
657323006678	adenylate kinase; Reviewed; Region: adk; PRK00279
657323006679	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
657323006680	AMP-binding site [chemical binding]; other site
657323006681	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
657323006682	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
657323006683	active site
657323006684	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
657323006685	rRNA binding site [nucleotide binding]; other site
657323006686	predicted 30S ribosome binding site; other site
657323006687	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
657323006688	Na2 binding site [ion binding]; other site
657323006689	putative substrate binding site 1 [chemical binding]; other site
657323006690	Na binding site 1 [ion binding]; other site
657323006691	putative substrate binding site 2 [chemical binding]; other site
657323006692	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
657323006693	DNA-binding site [nucleotide binding]; DNA binding site
657323006694	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
657323006695	UTRA domain; Region: UTRA; pfam07702
657323006696	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
657323006697	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
657323006698	30S ribosomal protein S13; Region: bact_S13; TIGR03631
657323006699	30S ribosomal protein S11; Validated; Region: PRK05309
657323006700	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
657323006701	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
657323006702	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
657323006703	RNA binding surface [nucleotide binding]; other site
657323006704	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
657323006705	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
657323006706	catalytic site [active]
657323006707	active site
657323006708	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
657323006709	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
657323006710	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
657323006711	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
657323006712	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
657323006713	catalytic triad [active]
657323006714	WYL domain; Region: WYL; pfam13280
657323006715	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657323006716	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657323006717	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657323006718	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657323006719	active site
657323006720	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
657323006721	putative homodimer interface [polypeptide binding]; other site
657323006722	putative homotetramer interface [polypeptide binding]; other site
657323006723	putative metal binding site [ion binding]; other site
657323006724	putative homodimer-homodimer interface [polypeptide binding]; other site
657323006725	putative allosteric switch controlling residues; other site
657323006726	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
657323006727	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
657323006728	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323006729	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323006730	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
657323006731	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
657323006732	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
657323006733	dimerization interface [polypeptide binding]; other site
657323006734	ATP binding site [chemical binding]; other site
657323006735	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
657323006736	dimerization interface [polypeptide binding]; other site
657323006737	ATP binding site [chemical binding]; other site
657323006738	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
657323006739	putative active site [active]
657323006740	catalytic triad [active]
657323006741	putative lipid kinase; Reviewed; Region: PRK13337
657323006742	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
657323006743	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
657323006744	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
657323006745	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
657323006746	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
657323006747	MoxR-like ATPases [General function prediction only]; Region: COG0714
657323006748	OPT oligopeptide transporter protein; Region: OPT; cl14607
657323006749	putative oligopeptide transporter, OPT family; Region: TIGR00733
657323006750	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
657323006751	Uncharacterized conserved protein [Function unknown]; Region: COG1284
657323006752	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
657323006753	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
657323006754	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
657323006755	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
657323006756	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323006757	Walker A/P-loop; other site
657323006758	ATP binding site [chemical binding]; other site
657323006759	Q-loop/lid; other site
657323006760	ABC transporter signature motif; other site
657323006761	Walker B; other site
657323006762	D-loop; other site
657323006763	H-loop/switch region; other site
657323006764	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
657323006765	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
657323006766	C-terminal peptidase (prc); Region: prc; TIGR00225
657323006767	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
657323006768	protein binding site [polypeptide binding]; other site
657323006769	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
657323006770	Catalytic dyad [active]
657323006771	Membrane transport protein; Region: Mem_trans; cl09117
657323006772	Domain of unknown function (DUF718); Region: DUF718; cl01281
657323006773	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
657323006774	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
657323006775	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
657323006776	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323006777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323006778	active site
657323006779	phosphorylation site [posttranslational modification]
657323006780	intermolecular recognition site; other site
657323006781	dimerization interface [polypeptide binding]; other site
657323006782	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323006783	DNA binding site [nucleotide binding]
657323006784	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323006785	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657323006786	dimerization interface [polypeptide binding]; other site
657323006787	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323006788	dimer interface [polypeptide binding]; other site
657323006789	phosphorylation site [posttranslational modification]
657323006790	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323006791	ATP binding site [chemical binding]; other site
657323006792	Mg2+ binding site [ion binding]; other site
657323006793	G-X-G motif; other site
657323006794	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
657323006795	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
657323006796	putative active site [active]
657323006797	oxyanion strand; other site
657323006798	catalytic triad [active]
657323006799	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
657323006800	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
657323006801	substrate binding site [chemical binding]; other site
657323006802	glutamase interaction surface [polypeptide binding]; other site
657323006803	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
657323006804	ligand binding site [chemical binding]; other site
657323006805	recombinase A; Provisional; Region: recA; PRK09354
657323006806	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
657323006807	hexamer interface [polypeptide binding]; other site
657323006808	Walker A motif; other site
657323006809	ATP binding site [chemical binding]; other site
657323006810	Walker B motif; other site
657323006811	recombination regulator RecX; Reviewed; Region: recX; PRK00117
657323006812	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323006813	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
657323006814	active site
657323006815	DNA binding site [nucleotide binding]
657323006816	Int/Topo IB signature motif; other site
657323006817	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
657323006818	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
657323006819	Predicted transcriptional regulator [Transcription]; Region: COG1959
657323006820	Transcriptional regulator; Region: Rrf2; cl17282
657323006821	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
657323006822	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
657323006823	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657323006824	catalytic residue [active]
657323006825	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
657323006826	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
657323006827	trimerization site [polypeptide binding]; other site
657323006828	active site
657323006829	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
657323006830	histidinol-phosphatase; Provisional; Region: PRK05588
657323006831	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
657323006832	active site
657323006833	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
657323006834	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
657323006835	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
657323006836	Phosphoglycerate kinase; Region: PGK; pfam00162
657323006837	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
657323006838	substrate binding site [chemical binding]; other site
657323006839	hinge regions; other site
657323006840	ADP binding site [chemical binding]; other site
657323006841	catalytic site [active]
657323006842	triosephosphate isomerase; Provisional; Region: PRK14567
657323006843	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
657323006844	substrate binding site [chemical binding]; other site
657323006845	dimer interface [polypeptide binding]; other site
657323006846	catalytic triad [active]
657323006847	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
657323006848	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
657323006849	phosphoglyceromutase; Provisional; Region: PRK05434
657323006850	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
657323006851	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323006852	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657323006853	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
657323006854	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
657323006855	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
657323006856	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
657323006857	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323006858	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140
657323006859	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
657323006860	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
657323006861	motif I; other site
657323006862	active site
657323006863	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
657323006864	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
657323006865	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
657323006866	minor groove reading motif; other site
657323006867	helix-hairpin-helix signature motif; other site
657323006868	substrate binding pocket [chemical binding]; other site
657323006869	active site
657323006870	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
657323006871	DNA binding and oxoG recognition site [nucleotide binding]
657323006872	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
657323006873	active site
657323006874	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
657323006875	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
657323006876	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
657323006877	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323006878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323006879	active site
657323006880	phosphorylation site [posttranslational modification]
657323006881	intermolecular recognition site; other site
657323006882	DNA topoisomerase III; Provisional; Region: PRK07726
657323006883	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
657323006884	active site
657323006885	putative interdomain interaction site [polypeptide binding]; other site
657323006886	putative metal-binding site [ion binding]; other site
657323006887	putative nucleotide binding site [chemical binding]; other site
657323006888	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
657323006889	domain I; other site
657323006890	DNA binding groove [nucleotide binding]
657323006891	phosphate binding site [ion binding]; other site
657323006892	domain II; other site
657323006893	domain III; other site
657323006894	nucleotide binding site [chemical binding]; other site
657323006895	catalytic site [active]
657323006896	domain IV; other site
657323006897	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
657323006898	Flagellin N-methylase; Region: FliB; pfam03692
657323006899	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323006900	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323006901	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
657323006902	putative dimerization interface [polypeptide binding]; other site
657323006903	Chorismate mutase type II; Region: CM_2; pfam01817
657323006904	shikimate kinase; Reviewed; Region: aroK; PRK00131
657323006905	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
657323006906	ADP binding site [chemical binding]; other site
657323006907	magnesium binding site [ion binding]; other site
657323006908	putative shikimate binding site; other site
657323006909	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323006910	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323006911	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
657323006912	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
657323006913	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
657323006914	active site
657323006915	FMN binding site [chemical binding]; other site
657323006916	substrate binding site [chemical binding]; other site
657323006917	putative catalytic residue [active]
657323006918	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
657323006919	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
657323006920	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
657323006921	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
657323006922	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
657323006923	shikimate binding site; other site
657323006924	NAD(P) binding site [chemical binding]; other site
657323006925	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
657323006926	Major Facilitator Superfamily; Region: MFS_1; pfam07690
657323006927	putative substrate translocation pore; other site
657323006928	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
657323006929	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
657323006930	active site
657323006931	catalytic residue [active]
657323006932	dimer interface [polypeptide binding]; other site
657323006933	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
657323006934	NAD(P) binding site [chemical binding]; other site
657323006935	shikimate binding site; other site
657323006936	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
657323006937	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
657323006938	NAD(P) binding pocket [chemical binding]; other site
657323006939	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
657323006940	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
657323006941	active site
657323006942	FMN binding site [chemical binding]; other site
657323006943	substrate binding site [chemical binding]; other site
657323006944	putative catalytic residue [active]
657323006945	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
657323006946	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
657323006947	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
657323006948	nudix motif; other site
657323006949	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
657323006950	putative hexamer interface [polypeptide binding]; other site
657323006951	putative hexagonal pore; other site
657323006952	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
657323006953	putative hexamer interface [polypeptide binding]; other site
657323006954	putative hexagonal pore; other site
657323006955	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
657323006956	G1 box; other site
657323006957	GTP/Mg2+ binding site [chemical binding]; other site
657323006958	G2 box; other site
657323006959	G3 box; other site
657323006960	Switch II region; other site
657323006961	G4 box; other site
657323006962	G5 box; other site
657323006963	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
657323006964	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
657323006965	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657323006966	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657323006967	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323006968	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323006969	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
657323006970	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
657323006971	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
657323006972	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
657323006973	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
657323006974	MFS/sugar transport protein; Region: MFS_2; pfam13347
657323006975	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
657323006976	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657323006977	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657323006978	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323006979	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
657323006980	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323006981	active site
657323006982	motif I; other site
657323006983	motif II; other site
657323006984	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323006985	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
657323006986	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657323006987	P-loop; other site
657323006988	Magnesium ion binding site [ion binding]; other site
657323006989	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
657323006990	Magnesium ion binding site [ion binding]; other site
657323006991	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
657323006992	ParB-like nuclease domain; Region: ParB; smart00470
657323006993	Cna protein B-type domain; Region: Cna_B; pfam05738
657323006994	RadC-like JAB domain; Region: RadC; pfam04002
657323006995	AAA domain; Region: AAA_21; pfam13304
657323006996	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
657323006997	Toprim-like; Region: Toprim_2; pfam13155
657323006998	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
657323006999	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657323007000	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323007001	DNA binding site [nucleotide binding]
657323007002	domain linker motif; other site
657323007003	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657323007004	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323007005	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657323007006	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323007007	dimer interface [polypeptide binding]; other site
657323007008	conserved gate region; other site
657323007009	putative PBP binding loops; other site
657323007010	ABC-ATPase subunit interface; other site
657323007011	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
657323007012	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
657323007013	substrate binding [chemical binding]; other site
657323007014	active site
657323007015	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
657323007016	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
657323007017	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
657323007018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
657323007019	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
657323007020	Histidine kinase; Region: His_kinase; pfam06580
657323007021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323007022	ATP binding site [chemical binding]; other site
657323007023	Mg2+ binding site [ion binding]; other site
657323007024	G-X-G motif; other site
657323007025	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323007026	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657323007027	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
657323007028	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323007029	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657323007030	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
657323007031	HTH domain; Region: HTH_11; cl17392
657323007032	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
657323007033	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
657323007034	nucleotide binding site [chemical binding]; other site
657323007035	NEF interaction site [polypeptide binding]; other site
657323007036	SBD interface [polypeptide binding]; other site
657323007037	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
657323007038	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
657323007039	substrate binding site [polypeptide binding]; other site
657323007040	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
657323007041	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
657323007042	Zn binding sites [ion binding]; other site
657323007043	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
657323007044	dimer interface [polypeptide binding]; other site
657323007045	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
657323007046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323007047	S-adenosylmethionine binding site [chemical binding]; other site
657323007048	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
657323007049	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
657323007050	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
657323007051	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657323007052	catalytic residue [active]
657323007053	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
657323007054	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
657323007055	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
657323007056	Ligand Binding Site [chemical binding]; other site
657323007057	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
657323007058	regulatory protein interface [polypeptide binding]; other site
657323007059	regulatory phosphorylation site [posttranslational modification]; other site
657323007060	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
657323007061	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
657323007062	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
657323007063	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323007064	FeS/SAM binding site; other site
657323007065	hypothetical protein; Provisional; Region: PRK05473
657323007066	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
657323007067	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
657323007068	Protein of unknown function (DUF964); Region: DUF964; pfam06133
657323007069	YceG-like family; Region: YceG; pfam02618
657323007070	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
657323007071	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782
657323007072	Peptidase family U32; Region: Peptidase_U32; pfam01136
657323007073	non-specific DNA binding site [nucleotide binding]; other site
657323007074	salt bridge; other site
657323007075	sequence-specific DNA binding site [nucleotide binding]; other site
657323007076	Helix-turn-helix domain; Region: HTH_31; pfam13560
657323007077	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
657323007078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
657323007079	intermolecular recognition site; other site
657323007080	active site
657323007081	dimerization interface [polypeptide binding]; other site
657323007082	LytTr DNA-binding domain; Region: LytTR; smart00850
657323007083	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
657323007084	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
657323007085	substrate binding pocket [chemical binding]; other site
657323007086	membrane-bound complex binding site; other site
657323007087	hinge residues; other site
657323007088	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
657323007089	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323007090	dimer interface [polypeptide binding]; other site
657323007091	conserved gate region; other site
657323007092	putative PBP binding loops; other site
657323007093	ABC-ATPase subunit interface; other site
657323007094	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
657323007095	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
657323007096	tetramer interface [polypeptide binding]; other site
657323007097	active site
657323007098	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
657323007099	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
657323007100	GDP-binding site [chemical binding]; other site
657323007101	ACT binding site; other site
657323007102	IMP binding site; other site
657323007103	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
657323007104	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323007105	motif II; other site
657323007106	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657323007107	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
657323007108	hypothetical protein; Provisional; Region: PRK05590
657323007109	SEC-C motif; Region: SEC-C; pfam02810
657323007110	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
657323007111	Uncharacterized conserved protein [Function unknown]; Region: COG1434
657323007112	putative active site [active]
657323007113	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
657323007114	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
657323007115	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
657323007116	shikimate binding site; other site
657323007117	NAD(P) binding site [chemical binding]; other site
657323007118	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
657323007119	sporulation sigma factor SigE; Reviewed; Region: PRK08301
657323007120	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
657323007121	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
657323007122	DNA binding residues [nucleotide binding]
657323007123	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
657323007124	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657323007125	Zn2+ binding site [ion binding]; other site
657323007126	Mg2+ binding site [ion binding]; other site
657323007127	prolyl-tRNA synthetase; Provisional; Region: PRK08661
657323007128	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
657323007129	dimer interface [polypeptide binding]; other site
657323007130	motif 1; other site
657323007131	active site
657323007132	motif 2; other site
657323007133	motif 3; other site
657323007134	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
657323007135	anticodon binding site; other site
657323007136	zinc-binding site [ion binding]; other site
657323007137	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
657323007138	active site
657323007139	NTP binding site [chemical binding]; other site
657323007140	metal binding triad [ion binding]; metal-binding site
657323007141	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
657323007142	HD domain; Region: HD; pfam01966
657323007143	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
657323007144	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
657323007145	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
657323007146	active site
657323007147	substrate binding site [chemical binding]; other site
657323007148	metal binding site [ion binding]; metal-binding site
657323007149	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
657323007150	IHF - DNA interface [nucleotide binding]; other site
657323007151	IHF dimer interface [polypeptide binding]; other site
657323007152	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
657323007153	RNA binding surface [nucleotide binding]; other site
657323007154	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
657323007155	Septum formation initiator; Region: DivIC; pfam04977
657323007156	stage II sporulation protein E; Region: spore_II_E; TIGR02865
657323007157	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
657323007158	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
657323007159	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
657323007160	Ligand Binding Site [chemical binding]; other site
657323007161	TilS substrate C-terminal domain; Region: TilS_C; smart00977
657323007162	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
657323007163	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657323007164	active site
657323007165	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
657323007166	homodimer interface [polypeptide binding]; other site
657323007167	maltodextrin glucosidase; Provisional; Region: PRK10785
657323007168	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
657323007169	active site
657323007170	homodimer interface [polypeptide binding]; other site
657323007171	catalytic site [active]
657323007172	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
657323007173	dimerization interface [polypeptide binding]; other site
657323007174	putative DNA binding site [nucleotide binding]; other site
657323007175	putative Zn2+ binding site [ion binding]; other site
657323007176	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
657323007177	Heavy-metal-associated domain; Region: HMA; pfam00403
657323007178	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
657323007179	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323007180	motif II; other site
657323007181	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
657323007182	putative active site [active]
657323007183	ZIP Zinc transporter; Region: Zip; pfam02535
657323007184	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
657323007185	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
657323007186	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
657323007187	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323007188	S-adenosylmethionine binding site [chemical binding]; other site
657323007189	Methyltransferase domain; Region: Methyltransf_23; pfam13489
657323007190	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
657323007191	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
657323007192	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
657323007193	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323007194	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323007195	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657323007196	dimerization interface [polypeptide binding]; other site
657323007197	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
657323007198	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
657323007199	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
657323007200	intersubunit interface [polypeptide binding]; other site
657323007201	active site
657323007202	zinc binding site [ion binding]; other site
657323007203	Na+ binding site [ion binding]; other site
657323007204	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
657323007205	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
657323007206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323007207	dimer interface [polypeptide binding]; other site
657323007208	conserved gate region; other site
657323007209	putative PBP binding loops; other site
657323007210	ABC-ATPase subunit interface; other site
657323007211	Response regulator receiver domain; Region: Response_reg; pfam00072
657323007212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323007213	active site
657323007214	phosphorylation site [posttranslational modification]
657323007215	intermolecular recognition site; other site
657323007216	dimerization interface [polypeptide binding]; other site
657323007217	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323007218	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657323007219	dimerization interface [polypeptide binding]; other site
657323007220	Histidine kinase; Region: His_kinase; pfam06580
657323007221	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323007222	ATP binding site [chemical binding]; other site
657323007223	Mg2+ binding site [ion binding]; other site
657323007224	G-X-G motif; other site
657323007225	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323007226	glycogen branching enzyme; Provisional; Region: PRK05402
657323007227	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
657323007228	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
657323007229	active site
657323007230	catalytic site [active]
657323007231	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
657323007232	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
657323007233	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
657323007234	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
657323007235	putative ATP binding site [chemical binding]; other site
657323007236	putative substrate binding site [chemical binding]; other site
657323007237	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
657323007238	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
657323007239	putative ligand binding site [chemical binding]; other site
657323007240	putative NAD binding site [chemical binding]; other site
657323007241	putative catalytic site [active]
657323007242	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
657323007243	L-serine binding site [chemical binding]; other site
657323007244	ACT domain interface; other site
657323007245	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
657323007246	homodimer interface [polypeptide binding]; other site
657323007247	substrate-cofactor binding pocket; other site
657323007248	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323007249	catalytic residue [active]
657323007250	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
657323007251	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
657323007252	PYR/PP interface [polypeptide binding]; other site
657323007253	dimer interface [polypeptide binding]; other site
657323007254	TPP binding site [chemical binding]; other site
657323007255	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
657323007256	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
657323007257	TPP-binding site [chemical binding]; other site
657323007258	dimer interface [polypeptide binding]; other site
657323007259	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
657323007260	6-phosphogluconate dehydratase; Region: edd; TIGR01196
657323007261	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
657323007262	tartrate dehydrogenase; Region: TTC; TIGR02089
657323007263	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
657323007264	Preprotein translocase subunit; Region: YajC; pfam02699
657323007265	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
657323007266	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
657323007267	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
657323007268	nucleotide binding site [chemical binding]; other site
657323007269	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
657323007270	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
657323007271	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
657323007272	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
657323007273	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
657323007274	Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546
657323007275	dinuclear metal binding motif [ion binding]; other site
657323007276	CotJB protein; Region: CotJB; pfam12652
657323007277	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
657323007278	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
657323007279	TrkA-N domain; Region: TrkA_N; pfam02254
657323007280	TrkA-C domain; Region: TrkA_C; pfam02080
657323007281	TrkA-N domain; Region: TrkA_N; pfam02254
657323007282	TrkA-C domain; Region: TrkA_C; pfam02080
657323007283	Cation transport protein; Region: TrkH; cl17365
657323007284	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
657323007285	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323007286	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323007287	DNA binding site [nucleotide binding]
657323007288	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323007289	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323007290	dimer interface [polypeptide binding]; other site
657323007291	phosphorylation site [posttranslational modification]
657323007292	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323007293	ATP binding site [chemical binding]; other site
657323007294	Mg2+ binding site [ion binding]; other site
657323007295	G-X-G motif; other site
657323007296	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
657323007297	catalytic motif [active]
657323007298	Zn binding site [ion binding]; other site
657323007299	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
657323007300	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
657323007301	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
657323007302	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
657323007303	Zn2+ binding site [ion binding]; other site
657323007304	Mg2+ binding site [ion binding]; other site
657323007305	Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662
657323007306	Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060
657323007307	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
657323007308	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
657323007309	active site
657323007310	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
657323007311	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
657323007312	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
657323007313	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
657323007314	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764
657323007315	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
657323007316	DNA binding residues [nucleotide binding]
657323007317	replicative DNA helicase; Region: DnaB; TIGR00665
657323007318	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
657323007319	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
657323007320	Walker A motif; other site
657323007321	ATP binding site [chemical binding]; other site
657323007322	Walker B motif; other site
657323007323	DNA binding loops [nucleotide binding]
657323007324	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
657323007325	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
657323007326	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
657323007327	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
657323007328	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
657323007329	DHH family; Region: DHH; pfam01368
657323007330	DHHA1 domain; Region: DHHA1; pfam02272
657323007331	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
657323007332	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
657323007333	dimer interface [polypeptide binding]; other site
657323007334	ssDNA binding site [nucleotide binding]; other site
657323007335	tetramer (dimer of dimers) interface [polypeptide binding]; other site
657323007336	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
657323007337	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
657323007338	NAD-dependent deacetylase; Provisional; Region: PRK00481
657323007339	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
657323007340	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
657323007341	ATP binding site [chemical binding]; other site
657323007342	active site
657323007343	substrate binding site [chemical binding]; other site
657323007344	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323007345	Walker A motif; other site
657323007346	ATP binding site [chemical binding]; other site
657323007347	Walker B motif; other site
657323007348	arginine finger; other site
657323007349	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
657323007350	metal ion-dependent adhesion site (MIDAS); other site
657323007351	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
657323007352	SdpI/YhfL protein family; Region: SdpI; pfam13630
657323007353	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
657323007354	dimerization interface [polypeptide binding]; other site
657323007355	putative DNA binding site [nucleotide binding]; other site
657323007356	putative Zn2+ binding site [ion binding]; other site
657323007357	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
657323007358	regulatory phosphorylation site [posttranslational modification]; other site
657323007359	6-phosphofructokinase; Provisional; Region: PRK14072
657323007360	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
657323007361	active site
657323007362	ADP/pyrophosphate binding site [chemical binding]; other site
657323007363	dimerization interface [polypeptide binding]; other site
657323007364	allosteric effector site; other site
657323007365	fructose-1,6-bisphosphate binding site; other site
657323007366	Uncharacterized conserved protein [Function unknown]; Region: COG3347
657323007367	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
657323007368	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
657323007369	active site
657323007370	catalytic triad [active]
657323007371	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
657323007372	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
657323007373	active site
657323007374	metal binding site [ion binding]; metal-binding site
657323007375	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
657323007376	PspC domain; Region: PspC; pfam04024
657323007377	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
657323007378	Predicted membrane protein [Function unknown]; Region: COG4709
657323007379	Predicted transcriptional regulators [Transcription]; Region: COG1695
657323007380	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
657323007381	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
657323007382	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
657323007383	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
657323007384	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
657323007385	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
657323007386	Family description; Region: UvrD_C_2; pfam13538
657323007387	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
657323007388	Part of AAA domain; Region: AAA_19; pfam13245
657323007389	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
657323007390	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
657323007391	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
657323007392	FMN-binding domain; Region: FMN_bind; cl01081
657323007393	NAD synthetase; Reviewed; Region: nadE; PRK02628
657323007394	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
657323007395	multimer interface [polypeptide binding]; other site
657323007396	active site
657323007397	catalytic triad [active]
657323007398	protein interface 1 [polypeptide binding]; other site
657323007399	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
657323007400	homodimer interface [polypeptide binding]; other site
657323007401	NAD binding pocket [chemical binding]; other site
657323007402	ATP binding pocket [chemical binding]; other site
657323007403	Mg binding site [ion binding]; other site
657323007404	active-site loop [active]
657323007405	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
657323007406	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
657323007407	dimerization interface [polypeptide binding]; other site
657323007408	domain crossover interface; other site
657323007409	redox-dependent activation switch; other site
657323007410	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
657323007411	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
657323007412	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657323007413	catalytic residue [active]
657323007414	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657323007415	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323007416	dimer interface [polypeptide binding]; other site
657323007417	conserved gate region; other site
657323007418	putative PBP binding loops; other site
657323007419	ABC-ATPase subunit interface; other site
657323007420	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323007421	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
657323007422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323007423	active site
657323007424	phosphorylation site [posttranslational modification]
657323007425	intermolecular recognition site; other site
657323007426	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323007427	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323007428	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323007429	Part of AAA domain; Region: AAA_19; pfam13245
657323007430	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
657323007431	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
657323007432	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
657323007433	putative active site [active]
657323007434	putative catalytic site [active]
657323007435	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
657323007436	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657323007437	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657323007438	catalytic residue [active]
657323007439	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
657323007440	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
657323007441	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
657323007442	Walker A/P-loop; other site
657323007443	ATP binding site [chemical binding]; other site
657323007444	Q-loop/lid; other site
657323007445	ABC transporter signature motif; other site
657323007446	Walker B; other site
657323007447	D-loop; other site
657323007448	H-loop/switch region; other site
657323007449	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
657323007450	Clp amino terminal domain; Region: Clp_N; pfam02861
657323007451	Clp amino terminal domain; Region: Clp_N; pfam02861
657323007452	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323007453	Walker A motif; other site
657323007454	ATP binding site [chemical binding]; other site
657323007455	Walker B motif; other site
657323007456	arginine finger; other site
657323007457	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323007458	Walker A motif; other site
657323007459	ATP binding site [chemical binding]; other site
657323007460	Walker B motif; other site
657323007461	arginine finger; other site
657323007462	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
657323007463	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323007464	H-loop/switch region; other site
657323007465	Domain of unknown function (DUF4319); Region: DUF4319; pfam14203
657323007466	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
657323007467	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
657323007468	Walker A/P-loop; other site
657323007469	ATP binding site [chemical binding]; other site
657323007470	Q-loop/lid; other site
657323007471	ABC transporter signature motif; other site
657323007472	Walker B; other site
657323007473	D-loop; other site
657323007474	H-loop/switch region; other site
657323007475	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
657323007476	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
657323007477	lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733
657323007478	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
657323007479	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323007480	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323007481	active site
657323007482	phosphorylation site [posttranslational modification]
657323007483	intermolecular recognition site; other site
657323007484	dimerization interface [polypeptide binding]; other site
657323007485	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323007486	DNA binding site [nucleotide binding]
657323007487	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323007488	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323007489	dimer interface [polypeptide binding]; other site
657323007490	phosphorylation site [posttranslational modification]
657323007491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323007492	ATP binding site [chemical binding]; other site
657323007493	Mg2+ binding site [ion binding]; other site
657323007494	G-X-G motif; other site
657323007495	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
657323007496	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323007497	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
657323007498	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
657323007499	nucleotide binding site [chemical binding]; other site
657323007500	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323007501	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323007502	active site
657323007503	phosphorylation site [posttranslational modification]
657323007504	intermolecular recognition site; other site
657323007505	dimerization interface [polypeptide binding]; other site
657323007506	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323007507	DNA binding site [nucleotide binding]
657323007508	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323007509	dimer interface [polypeptide binding]; other site
657323007510	phosphorylation site [posttranslational modification]
657323007511	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
657323007512	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323007513	ATP binding site [chemical binding]; other site
657323007514	Mg2+ binding site [ion binding]; other site
657323007515	G-X-G motif; other site
657323007516	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
657323007517	GAF domain; Region: GAF; cl17456
657323007518	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
657323007519	TrkA-N domain; Region: TrkA_N; pfam02254
657323007520	TrkA-C domain; Region: TrkA_C; pfam02080
657323007521	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
657323007522	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
657323007523	biotin synthase; Region: bioB; TIGR00433
657323007524	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323007525	FeS/SAM binding site; other site
657323007526	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
657323007527	BioY family; Region: BioY; pfam02632
657323007528	Predicted membrane protein [Function unknown]; Region: COG4905
657323007529	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
657323007530	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
657323007531	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
657323007532	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
657323007533	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
657323007534	active site
657323007535	DNA binding site [nucleotide binding]
657323007536	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
657323007537	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
657323007538	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
657323007539	DNA binding site [nucleotide binding]
657323007540	active site
657323007541	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
657323007542	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
657323007543	Potassium binding sites [ion binding]; other site
657323007544	Cesium cation binding sites [ion binding]; other site
657323007545	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
657323007546	putative substrate binding site 1 [chemical binding]; other site
657323007547	Na binding site 1 [ion binding]; other site
657323007548	Na2 binding site [ion binding]; other site
657323007549	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
657323007550	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657323007551	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323007552	non-specific DNA binding site [nucleotide binding]; other site
657323007553	salt bridge; other site
657323007554	sequence-specific DNA binding site [nucleotide binding]; other site
657323007555	4Fe-4S binding domain; Region: Fer4_5; pfam12801
657323007556	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
657323007557	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
657323007558	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
657323007559	catalytic residues [active]
657323007560	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323007561	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323007562	active site
657323007563	phosphorylation site [posttranslational modification]
657323007564	intermolecular recognition site; other site
657323007565	dimerization interface [polypeptide binding]; other site
657323007566	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323007567	DNA binding site [nucleotide binding]
657323007568	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657323007569	dimerization interface [polypeptide binding]; other site
657323007570	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323007571	dimer interface [polypeptide binding]; other site
657323007572	phosphorylation site [posttranslational modification]
657323007573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323007574	ATP binding site [chemical binding]; other site
657323007575	Mg2+ binding site [ion binding]; other site
657323007576	G-X-G motif; other site
657323007577	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
657323007578	hypothetical protein; Provisional; Region: PRK06762
657323007579	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
657323007580	Uncharacterized conserved protein [Function unknown]; Region: COG2006
657323007581	4Fe-4S binding domain; Region: Fer4; pfam00037
657323007582	Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050
657323007583	Transcriptional regulator [Transcription]; Region: LysR; COG0583
657323007584	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
657323007585	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
657323007586	dimerization interface [polypeptide binding]; other site
657323007587	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
657323007588	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
657323007589	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
657323007590	putative L-serine binding site [chemical binding]; other site
657323007591	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
657323007592	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
657323007593	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
657323007594	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
657323007595	synthetase active site [active]
657323007596	NTP binding site [chemical binding]; other site
657323007597	metal binding site [ion binding]; metal-binding site
657323007598	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
657323007599	Nitrogen regulatory protein P-II; Region: P-II; smart00938
657323007600	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
657323007601	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
657323007602	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
657323007603	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
657323007604	putative NADH binding site [chemical binding]; other site
657323007605	putative active site [active]
657323007606	nudix motif; other site
657323007607	putative metal binding site [ion binding]; other site
657323007608	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
657323007609	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
657323007610	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657323007611	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323007612	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323007613	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323007614	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189
657323007615	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
657323007616	putative active site [active]
657323007617	metal binding site [ion binding]; metal-binding site
657323007618	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
657323007619	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
657323007620	NAD(P) binding site [chemical binding]; other site
657323007621	catalytic residues [active]
657323007622	Probable beta-xylosidase; Provisional; Region: PLN03080
657323007623	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
657323007624	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
657323007625	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
657323007626	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
657323007627	substrate binding site [chemical binding]; other site
657323007628	active site
657323007629	catalytic residues [active]
657323007630	heterodimer interface [polypeptide binding]; other site
657323007631	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
657323007632	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
657323007633	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323007634	catalytic residue [active]
657323007635	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
657323007636	active site
657323007637	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
657323007638	active site
657323007639	ribulose/triose binding site [chemical binding]; other site
657323007640	phosphate binding site [ion binding]; other site
657323007641	substrate (anthranilate) binding pocket [chemical binding]; other site
657323007642	product (indole) binding pocket [chemical binding]; other site
657323007643	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
657323007644	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
657323007645	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
657323007646	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
657323007647	Glutamine amidotransferase class-I; Region: GATase; pfam00117
657323007648	glutamine binding [chemical binding]; other site
657323007649	catalytic triad [active]
657323007650	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
657323007651	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
657323007652	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
657323007653	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
657323007654	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
657323007655	synthetase active site [active]
657323007656	NTP binding site [chemical binding]; other site
657323007657	metal binding site [ion binding]; metal-binding site
657323007658	Helix-turn-helix domain; Region: HTH_18; pfam12833
657323007659	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323007660	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323007661	ATP binding site [chemical binding]; other site
657323007662	Mg2+ binding site [ion binding]; other site
657323007663	G-X-G motif; other site
657323007664	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
657323007665	catalytic site [active]
657323007666	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
657323007667	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
657323007668	N- and C-terminal domain interface [polypeptide binding]; other site
657323007669	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
657323007670	active site
657323007671	putative catalytic site [active]
657323007672	metal binding site [ion binding]; metal-binding site
657323007673	ATP binding site [chemical binding]; other site
657323007674	carbohydrate binding site [chemical binding]; other site
657323007675	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657323007676	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657323007677	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323007678	H-loop/switch region; other site
657323007679	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
657323007680	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
657323007681	Walker A/P-loop; other site
657323007682	ATP binding site [chemical binding]; other site
657323007683	Q-loop/lid; other site
657323007684	ABC transporter signature motif; other site
657323007685	Walker B; other site
657323007686	D-loop; other site
657323007687	H-loop/switch region; other site
657323007688	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
657323007689	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657323007690	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
657323007691	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
657323007692	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
657323007693	Cache domain; Region: Cache_1; pfam02743
657323007694	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
657323007695	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
657323007696	dimerization interface [polypeptide binding]; other site
657323007697	Histidine kinase; Region: His_kinase; pfam06580
657323007698	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323007699	ATP binding site [chemical binding]; other site
657323007700	Mg2+ binding site [ion binding]; other site
657323007701	G-X-G motif; other site
657323007702	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
657323007703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323007704	active site
657323007705	phosphorylation site [posttranslational modification]
657323007706	intermolecular recognition site; other site
657323007707	dimerization interface [polypeptide binding]; other site
657323007708	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
657323007709	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
657323007710	active site
657323007711	catalytic tetrad [active]
657323007712	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
657323007713	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
657323007714	putative substrate binding site [chemical binding]; other site
657323007715	putative ATP binding site [chemical binding]; other site
657323007716	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
657323007717	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
657323007718	putative NAD(P) binding site [chemical binding]; other site
657323007719	catalytic Zn binding site [ion binding]; other site
657323007720	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
657323007721	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
657323007722	N- and C-terminal domain interface [polypeptide binding]; other site
657323007723	putative active site [active]
657323007724	MgATP binding site [chemical binding]; other site
657323007725	catalytic site [active]
657323007726	metal binding site [ion binding]; metal-binding site
657323007727	putative xylulose binding site [chemical binding]; other site
657323007728	putative homodimer interface [polypeptide binding]; other site
657323007729	Transcriptional regulators [Transcription]; Region: PurR; COG1609
657323007730	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
657323007731	DNA binding site [nucleotide binding]
657323007732	domain linker motif; other site
657323007733	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
657323007734	dimerization interface [polypeptide binding]; other site
657323007735	ligand binding site [chemical binding]; other site
657323007736	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
657323007737	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
657323007738	intersubunit interface [polypeptide binding]; other site
657323007739	active site
657323007740	zinc binding site [ion binding]; other site
657323007741	Na+ binding site [ion binding]; other site
657323007742	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
657323007743	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
657323007744	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
657323007745	UDP-galactopyranose mutase; Region: GLF; pfam03275
657323007746	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
657323007747	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657323007748	active site
657323007749	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
657323007750	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
657323007751	NAD(P) binding site [chemical binding]; other site
657323007752	active site
657323007753	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
657323007754	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
657323007755	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657323007756	active site
657323007757	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657323007758	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657323007759	active site
657323007760	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
657323007761	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
657323007762	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
657323007763	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
657323007764	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
657323007765	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
657323007766	UDP-galactopyranose mutase; Region: GLF; pfam03275
657323007767	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
657323007768	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
657323007769	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323007770	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323007771	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
657323007772	DNA binding site [nucleotide binding]
657323007773	active site
657323007774	Int/Topo IB signature motif; other site
657323007775	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
657323007776	UDP-glucose 4-epimerase; Region: PLN02240
657323007777	NAD binding site [chemical binding]; other site
657323007778	homodimer interface [polypeptide binding]; other site
657323007779	active site
657323007780	substrate binding site [chemical binding]; other site
657323007781	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
657323007782	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
657323007783	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
657323007784	dimer interface [polypeptide binding]; other site
657323007785	phosphorylation site [posttranslational modification]
657323007786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
657323007787	ATP binding site [chemical binding]; other site
657323007788	Mg2+ binding site [ion binding]; other site
657323007789	G-X-G motif; other site
657323007790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
657323007791	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
657323007792	active site
657323007793	phosphorylation site [posttranslational modification]
657323007794	intermolecular recognition site; other site
657323007795	dimerization interface [polypeptide binding]; other site
657323007796	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
657323007797	DNA binding site [nucleotide binding]
657323007798	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
657323007799	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
657323007800	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
657323007801	PhoU domain; Region: PhoU; pfam01895
657323007802	PhoU domain; Region: PhoU; pfam01895
657323007803	transcription elongation factor GreA; Region: greA; TIGR01462
657323007804	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
657323007805	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
657323007806	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
657323007807	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
657323007808	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
657323007809	G1 box; other site
657323007810	putative GEF interaction site [polypeptide binding]; other site
657323007811	GTP/Mg2+ binding site [chemical binding]; other site
657323007812	Switch I region; other site
657323007813	G2 box; other site
657323007814	G3 box; other site
657323007815	Switch II region; other site
657323007816	G4 box; other site
657323007817	G5 box; other site
657323007818	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
657323007819	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
657323007820	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
657323007821	YacP-like NYN domain; Region: NYN_YacP; pfam05991
657323007822	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
657323007823	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
657323007824	active site
657323007825	nucleophile elbow; other site
657323007826	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
657323007827	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657323007828	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657323007829	ABC transporter; Region: ABC_tran_2; pfam12848
657323007830	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
657323007831	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
657323007832	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
657323007833	active site
657323007834	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
657323007835	putative active site [active]
657323007836	catalytic site [active]
657323007837	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
657323007838	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
657323007839	PLD-like domain; Region: PLDc_2; pfam13091
657323007840	putative active site [active]
657323007841	catalytic site [active]
657323007842	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
657323007843	Domain of unknown function (DUF955); Region: DUF955; pfam06114
657323007844	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657323007845	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323007846	non-specific DNA binding site [nucleotide binding]; other site
657323007847	salt bridge; other site
657323007848	sequence-specific DNA binding site [nucleotide binding]; other site
657323007849	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
657323007850	von Willebrand factor type A domain; Region: VWA_2; pfam13519
657323007851	metal ion-dependent adhesion site (MIDAS); other site
657323007852	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
657323007853	putative ADP-ribose binding site [chemical binding]; other site
657323007854	putative active site [active]
657323007855	RNA polymerase sigma factor; Reviewed; Region: PRK12527
657323007856	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
657323007857	23S rRNA interface [nucleotide binding]; other site
657323007858	L3 interface [polypeptide binding]; other site
657323007859	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
657323007860	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
657323007861	dimerization interface 3.5A [polypeptide binding]; other site
657323007862	active site
657323007863	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
657323007864	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
657323007865	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
657323007866	Walker A/P-loop; other site
657323007867	ATP binding site [chemical binding]; other site
657323007868	Q-loop/lid; other site
657323007869	ABC transporter signature motif; other site
657323007870	Walker B; other site
657323007871	D-loop; other site
657323007872	H-loop/switch region; other site
657323007873	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
657323007874	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
657323007875	Walker A/P-loop; other site
657323007876	ATP binding site [chemical binding]; other site
657323007877	Q-loop/lid; other site
657323007878	ABC transporter signature motif; other site
657323007879	Walker B; other site
657323007880	D-loop; other site
657323007881	H-loop/switch region; other site
657323007882	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
657323007883	G1 box; other site
657323007884	GTP/Mg2+ binding site [chemical binding]; other site
657323007885	Switch I region; other site
657323007886	G2 box; other site
657323007887	G3 box; other site
657323007888	Switch II region; other site
657323007889	G4 box; other site
657323007890	G5 box; other site
657323007891	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
657323007892	Found in ATP-dependent protease La (LON); Region: LON; smart00464
657323007893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323007894	Walker A motif; other site
657323007895	ATP binding site [chemical binding]; other site
657323007896	Walker B motif; other site
657323007897	arginine finger; other site
657323007898	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
657323007899	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
657323007900	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
657323007901	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323007902	Walker A motif; other site
657323007903	ATP binding site [chemical binding]; other site
657323007904	Walker B motif; other site
657323007905	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
657323007906	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
657323007907	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
657323007908	oligomer interface [polypeptide binding]; other site
657323007909	active site residues [active]
657323007910	trigger factor; Provisional; Region: tig; PRK01490
657323007911	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
657323007912	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
657323007913	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
657323007914	active site
657323007915	catalytic triad [active]
657323007916	oxyanion hole [active]
657323007917	DJ-1 family protein; Region: not_thiJ; TIGR01383
657323007918	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
657323007919	conserved cys residue [active]
657323007920	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
657323007921	putative active site; other site
657323007922	signature motif; other site
657323007923	putative triphosphate binding site [ion binding]; other site
657323007924	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
657323007925	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
657323007926	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
657323007927	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657323007928	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
657323007929	catalytic residue [active]
657323007930	NMT1-like family; Region: NMT1_2; pfam13379
657323007931	NMT1/THI5 like; Region: NMT1; pfam09084
657323007932	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
657323007933	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
657323007934	non-specific DNA binding site [nucleotide binding]; other site
657323007935	salt bridge; other site
657323007936	sequence-specific DNA binding site [nucleotide binding]; other site
657323007937	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
657323007938	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
657323007939	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
657323007940	homodimer interface [polypeptide binding]; other site
657323007941	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323007942	catalytic residue [active]
657323007943	dipeptidase PepV; Reviewed; Region: PRK07318
657323007944	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
657323007945	active site
657323007946	metal binding site [ion binding]; metal-binding site
657323007947	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
657323007948	Melibiase; Region: Melibiase; pfam02065
657323007949	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657323007950	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323007951	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323007952	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
657323007953	metal binding site 2 [ion binding]; metal-binding site
657323007954	putative DNA binding helix; other site
657323007955	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
657323007956	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
657323007957	Walker A/P-loop; other site
657323007958	ATP binding site [chemical binding]; other site
657323007959	Q-loop/lid; other site
657323007960	ABC transporter signature motif; other site
657323007961	Walker B; other site
657323007962	D-loop; other site
657323007963	H-loop/switch region; other site
657323007964	TOBE domain; Region: TOBE; pfam03459
657323007965	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
657323007966	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
657323007967	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323007968	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
657323007969	Walker A/P-loop; other site
657323007970	ATP binding site [chemical binding]; other site
657323007971	Q-loop/lid; other site
657323007972	ABC transporter signature motif; other site
657323007973	Walker B; other site
657323007974	D-loop; other site
657323007975	H-loop/switch region; other site
657323007976	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
657323007977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323007978	dimer interface [polypeptide binding]; other site
657323007979	conserved gate region; other site
657323007980	putative PBP binding loops; other site
657323007981	ABC-ATPase subunit interface; other site
657323007982	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
657323007983	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
657323007984	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
657323007985	Helix-turn-helix domain; Region: HTH_17; pfam12728
657323007986	PBP superfamily domain; Region: PBP_like; pfam12727
657323007987	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
657323007988	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
657323007989	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
657323007990	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
657323007991	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
657323007992	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
657323007993	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
657323007994	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
657323007995	ATP-grasp domain; Region: ATP-grasp_4; cl17255
657323007996	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
657323007997	IMP binding site; other site
657323007998	dimer interface [polypeptide binding]; other site
657323007999	interdomain contacts; other site
657323008000	partial ornithine binding site; other site
657323008001	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
657323008002	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
657323008003	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
657323008004	catalytic site [active]
657323008005	subunit interface [polypeptide binding]; other site
657323008006	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
657323008007	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
657323008008	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
657323008009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
657323008010	Walker A motif; other site
657323008011	ATP binding site [chemical binding]; other site
657323008012	Walker B motif; other site
657323008013	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
657323008014	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
657323008015	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
657323008016	protein binding site [polypeptide binding]; other site
657323008017	Transcriptional regulator [Transcription]; Region: LytR; COG1316
657323008018	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
657323008019	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
657323008020	Probable Catalytic site; other site
657323008021	metal-binding site
657323008022	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
657323008023	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
657323008024	Probable Catalytic site; other site
657323008025	metal-binding site
657323008026	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
657323008027	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
657323008028	Probable Catalytic site; other site
657323008029	metal-binding site
657323008030	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
657323008031	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
657323008032	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
657323008033	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
657323008034	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
657323008035	Probable Catalytic site; other site
657323008036	metal-binding site
657323008037	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
657323008038	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
657323008039	Probable Catalytic site; other site
657323008040	metal-binding site
657323008041	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323008042	S-adenosylmethionine binding site [chemical binding]; other site
657323008043	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
657323008044	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
657323008045	Probable Catalytic site; other site
657323008046	metal-binding site
657323008047	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
657323008048	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
657323008049	Walker A/P-loop; other site
657323008050	ATP binding site [chemical binding]; other site
657323008051	Q-loop/lid; other site
657323008052	ABC transporter signature motif; other site
657323008053	Walker B; other site
657323008054	D-loop; other site
657323008055	H-loop/switch region; other site
657323008056	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
657323008057	putative carbohydrate binding site [chemical binding]; other site
657323008058	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
657323008059	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
657323008060	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
657323008061	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
657323008062	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
657323008063	inhibitor-cofactor binding pocket; inhibition site
657323008064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
657323008065	catalytic residue [active]
657323008066	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
657323008067	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
657323008068	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
657323008069	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
657323008070	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
657323008071	Ligand binding site; other site
657323008072	Putative Catalytic site; other site
657323008073	DXD motif; other site
657323008074	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
657323008075	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
657323008076	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
657323008077	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
657323008078	active site
657323008079	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
657323008080	dimerization domain swap beta strand [polypeptide binding]; other site
657323008081	regulatory protein interface [polypeptide binding]; other site
657323008082	active site
657323008083	regulatory phosphorylation site [posttranslational modification]; other site
657323008084	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
657323008085	Uncharacterized conserved protein [Function unknown]; Region: COG1624
657323008086	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
657323008087	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
657323008088	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
657323008089	active site
657323008090	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
657323008091	AAA domain; Region: AAA_30; pfam13604
657323008092	Family description; Region: UvrD_C_2; pfam13538
657323008093	rod shape-determining protein MreB; Provisional; Region: PRK13930
657323008094	MreB and similar proteins; Region: MreB_like; cd10225
657323008095	nucleotide binding site [chemical binding]; other site
657323008096	Mg binding site [ion binding]; other site
657323008097	putative protofilament interaction site [polypeptide binding]; other site
657323008098	RodZ interaction site [polypeptide binding]; other site
657323008099	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
657323008100	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
657323008101	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
657323008102	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
657323008103	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
657323008104	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323008105	FeS/SAM binding site; other site
657323008106	HemN C-terminal domain; Region: HemN_C; pfam06969
657323008107	GTP-binding protein LepA; Provisional; Region: PRK05433
657323008108	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
657323008109	G1 box; other site
657323008110	putative GEF interaction site [polypeptide binding]; other site
657323008111	GTP/Mg2+ binding site [chemical binding]; other site
657323008112	Switch I region; other site
657323008113	G2 box; other site
657323008114	G3 box; other site
657323008115	Switch II region; other site
657323008116	G4 box; other site
657323008117	G5 box; other site
657323008118	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
657323008119	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
657323008120	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
657323008121	stage II sporulation protein P; Region: spore_II_P; TIGR02867
657323008122	germination protease; Provisional; Region: PRK12362
657323008123	Protein of unknown function DUF45; Region: DUF45; pfam01863
657323008124	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
657323008125	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
657323008126	glycerol kinase; Provisional; Region: glpK; PRK00047
657323008127	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
657323008128	N- and C-terminal domain interface [polypeptide binding]; other site
657323008129	active site
657323008130	MgATP binding site [chemical binding]; other site
657323008131	catalytic site [active]
657323008132	metal binding site [ion binding]; metal-binding site
657323008133	glycerol binding site [chemical binding]; other site
657323008134	homotetramer interface [polypeptide binding]; other site
657323008135	homodimer interface [polypeptide binding]; other site
657323008136	FBP binding site [chemical binding]; other site
657323008137	protein IIAGlc interface [polypeptide binding]; other site
657323008138	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
657323008139	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
657323008140	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
657323008141	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
657323008142	active site
657323008143	catalytic site [active]
657323008144	metal binding site [ion binding]; metal-binding site
657323008145	dimer interface [polypeptide binding]; other site
657323008146	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
657323008147	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
657323008148	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
657323008149	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
657323008150	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
657323008151	Predicted dehydrogenase [General function prediction only]; Region: COG0579
657323008152	hydroxyglutarate oxidase; Provisional; Region: PRK11728
657323008153	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
657323008154	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
657323008155	MgtC family; Region: MgtC; pfam02308
657323008156	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
657323008157	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
657323008158	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
657323008159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323008160	dimer interface [polypeptide binding]; other site
657323008161	conserved gate region; other site
657323008162	putative PBP binding loops; other site
657323008163	ABC-ATPase subunit interface; other site
657323008164	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
657323008165	dimer interface [polypeptide binding]; other site
657323008166	conserved gate region; other site
657323008167	putative PBP binding loops; other site
657323008168	ABC-ATPase subunit interface; other site
657323008169	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
657323008170	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
657323008171	galactokinase; Provisional; Region: PRK00555
657323008172	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
657323008173	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
657323008174	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
657323008175	N- and C-terminal domain interface [polypeptide binding]; other site
657323008176	D-xylulose kinase; Region: XylB; TIGR01312
657323008177	active site
657323008178	MgATP binding site [chemical binding]; other site
657323008179	catalytic site [active]
657323008180	metal binding site [ion binding]; metal-binding site
657323008181	xylulose binding site [chemical binding]; other site
657323008182	homodimer interface [polypeptide binding]; other site
657323008183	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
657323008184	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
657323008185	hexamer (dimer of trimers) interface [polypeptide binding]; other site
657323008186	substrate binding site [chemical binding]; other site
657323008187	trimer interface [polypeptide binding]; other site
657323008188	Mn binding site [ion binding]; other site
657323008189	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
657323008190	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
657323008191	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
657323008192	Sodium Bile acid symporter family; Region: SBF; cl17470
657323008193	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
657323008194	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
657323008195	Ligand binding site; other site
657323008196	Putative Catalytic site; other site
657323008197	DXD motif; other site
657323008198	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
657323008199	putative deacylase active site [active]
657323008200	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
657323008201	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
657323008202	putative Cl- selectivity filter; other site
657323008203	putative pore gating glutamate residue; other site
657323008204	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
657323008205	Acyltransferase family; Region: Acyl_transf_3; pfam01757
657323008206	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
657323008207	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
657323008208	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
657323008209	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323008210	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
657323008211	active site
657323008212	motif I; other site
657323008213	motif II; other site
657323008214	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
657323008215	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
657323008216	S-adenosylmethionine binding site [chemical binding]; other site
657323008217	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
657323008218	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
657323008219	FtsX-like permease family; Region: FtsX; pfam02687
657323008220	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
657323008221	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
657323008222	HlyD family secretion protein; Region: HlyD_3; pfam13437
657323008223	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
657323008224	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
657323008225	Walker A/P-loop; other site
657323008226	ATP binding site [chemical binding]; other site
657323008227	Q-loop/lid; other site
657323008228	ABC transporter signature motif; other site
657323008229	Walker B; other site
657323008230	D-loop; other site
657323008231	H-loop/switch region; other site
657323008232	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
657323008233	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
657323008234	oligomer interface [polypeptide binding]; other site
657323008235	putative active site [active]
657323008236	metal binding site [ion binding]; metal-binding site
657323008237	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
657323008238	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
657323008239	Walker A/P-loop; other site
657323008240	ATP binding site [chemical binding]; other site
657323008241	Q-loop/lid; other site
657323008242	ABC transporter signature motif; other site
657323008243	Walker B; other site
657323008244	D-loop; other site
657323008245	H-loop/switch region; other site
657323008246	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
657323008247	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
657323008248	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
657323008249	[FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956
657323008250	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
657323008251	FeS/SAM binding site; other site
657323008252	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
657323008253	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
657323008254	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
657323008255	putative ATP binding site [chemical binding]; other site
657323008256	putative substrate interface [chemical binding]; other site
657323008257	Protein of unknown function (DUF3268); Region: DUF3268; pfam11672
657323008258	Protein of unknown function (DUF3268); Region: DUF3268; pfam11672