-- dump date 20140620_041906 -- class Genbank::CDS -- table cds_note -- id note YP_611162.1 PFAM: Hemolysin-type calcium-binding region: (0.15); KEGG: tdn:Tmden_0243 hemolysin-type calcium-binding region, ev=3e-78, 36% identity YP_611163.1 KEGG: xcb:XC_2789 hypothetical protein, ev=6e-14, 47% identity YP_611166.1 KEGG: rsp:RSP_3991 hypothetical protein, ev=1e-99, 57% identity YP_611167.1 KEGG: jan:Jann_4266 RepA, ev=1e-126, 68% identity YP_611168.1 PFAM: Cobyrinic acid a,c-diamide synthase: (2.1e-23); KEGG: jan:Jann_4265 cobyrinic acid a,c-diamide synthase, ev=0.0, 75% identity YP_611169.1 PFAM: ParB-like nuclease: (6e-05); KEGG: jan:Jann_4264 ParB-like nuclease, ev=1e-48, 36% identity YP_611170.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase: (1.3e-54); KEGG: jan:Jann_0076 UDP-glucose 6-dehydrogenase, ev=0.0, 79% identity YP_611171.1 PFAM: NAD-dependent epimerase/dehydratase: (4.1e-55) 3-beta hydroxysteroid dehydrogenase/isomerase: (3e-06) dTDP-4-dehydrorhamnose reductase: (0.0013) Male sterility-like: (8.1e-07); KEGG: jan:Jann_0077 NAD-dependent epimerase/dehydratase, ev=1e-126, 67% identity YP_611172.1 PFAM: helix-turn-helix motif: (2e-07); KEGG: jan:Jann_1232 transcriptional regulator, XRE family, ev=2e-29, 54% identity YP_611173.1 KEGG: rsp:RSP_0834 mannose-6-phosphate isomerase / mannose-1-phosphate guanylyltransferase, ev=0.0, 66% identity; TIGRFAM: Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase: (4.9e-192); PFAM: mannose-6-phosphate isomerase, type II: (8.6e-88) Nucleotidyl transferase: (2.4e-85) Cupin 2, conserved barrel: (1.3e-12) YP_611174.1 PFAM: Domain of unknown function DUF1738: (4.4e-59); KEGG: jan:Jann_3213 antirestriction protein-like, ev=1e-116, 90% identity YP_611175.1 KEGG: jan:Jann_0647 hypothetical protein, ev=7e-82, 56% identity YP_611176.1 PFAM: Methionine sulfoxide reductase B: (4.5e-58); KEGG: sme:SMc01724 hypothetical protein, ev=8e-54, 61% identity YP_611177.1 PFAM: beta-Ig-H3/fasciclin: (2.9e-41); KEGG: mlo:mlr4813 similar to secreted protein MPB70 (and transforming growth factor-induced protein), ev=3e-56, 64% identity YP_611178.1 KEGG: jan:Jann_0649 hypothetical protein, ev=2e-42, 45% identity YP_611179.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_611180.1 PFAM: Hemolysin-type calcium-binding region: (0.0021); KEGG: sil:SPO1626 type I secretion target repeat protein, ev=5e-86, 32% identity YP_611182.1 PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type: (0.092) YP_611183.1 KEGG: rsp:RSP_7254 hypothetical protein, ev=2e-23, 45% identity YP_611184.1 SMART: Staphylococcus nuclease (SNase-like): (3.9e-06); KEGG: jan:Jann_3714 nuclease (SNase-like), ev=3e-21, 46% identity YP_611187.1 PFAM: Relaxase/mobilization nuclease domain: (1.5e-05); KEGG: atc:AGR_pTi_21 T-DNA border endonuclease virD2, ev=1e-18, 33% identity YP_611188.1 PFAM: TRAG protein: (3.6e-71); KEGG: ret:RHE_PA00070 transport secretion system IV, VirD4 protein, ev=2e-77, 34% identity YP_611189.1 PFAM: ATP-binding region, ATPase-like: (5.1e-35) histidine kinase A-like: (2.1e-10); SMART: extracellular solute-binding protein, family 3: (7.6e-22); KEGG: rba:RB9418 signal-transducing histidine kinase, ev=1e-36, 29% identity YP_611194.1 PFAM: protein of unknown function DUF1625: (2.9e-40); KEGG: mlo:mll2895 hypothetical protein, ev=3e-77, 40% identity YP_611197.1 KEGG: sil:SPO3001 hypothetical protein, ev=4e-19, 34% identity YP_611202.1 PFAM: regulatory protein, LuxR: (5.9e-05) YP_611203.1 PFAM: TrbL/VirB6 plasmid conjugal transfer protein: (3.9e-10); KEGG: lpn:lpg1250 LvhB6, ev=1e-12, 27% identity YP_611206.1 PFAM: type II secretion system protein E: (3.9e-47); KEGG: ama:AM1313 VirB11 protein, ev=4e-45, 36% identity YP_611207.1 PFAM: conjugation TrbI-like protein: (1.2e-61); KEGG: mlo:mlr9259 conjugal transfer protein, ev=3e-38, 36% identity YP_611208.1 PFAM: Conjugal transfer protein TrbG/VirB9/CagX: (2.8e-41); KEGG: mlo:mlr9258 conjugal transfer protein, trbG, ev=3e-25, 32% identity YP_611209.1 PFAM: VirB8: (7.9e-10); KEGG: atc:AGR_pAT_228 virB8 type IV secretion protein, ev=7e-11, 26% identity YP_611210.1 KEGG: xoo:XOO0603 TraF protein, ev=7e-07, 24% identity YP_611211.1 PFAM: Lytic transglycosylase, catalytic: (7.1e-19); KEGG: bsu:BG13596 similar to lytic transglycosylase, ev=1e-26, 57% identity YP_611213.1 PFAM: CagE, TrbE, VirB component of type IV transporter system: (3.2e-19); SMART: ATPase: (1.2e-07); KEGG: ccr:CC2419 type IV secretion system protein B4, putative, ev=1e-100, 34% identity YP_611214.1 PFAM: type IV secretory pathway, VirB3-like: (2.2e-09) YP_611215.1 PFAM: VIRB2 type IV secretion: (7.3e-06); KEGG: atc:AGR_pAT_220 type IV secretion system protein VirB2, ev=1e-09, 36% identity YP_611216.1 PFAM: Lytic transglycosylase, catalytic: (2.9e-17); KEGG: mta:Moth_1608 lytic transglycosylase, catalytic, ev=1e-24, 41% identity YP_611222.1 PFAM: short-chain dehydrogenase/reductase SDR: (1.8e-07); KEGG: sme:SMc00136 putative oxidoreductase protein, ev=1e-95, 69% identity YP_611223.1 PFAM: regulatory protein, LysR: (3e-16) LysR, substrate-binding: (1e-25); KEGG: mlo:mlr1832 probable transcriptional regulator, ev=7e-75, 51% identity YP_611225.1 PFAM: glycosyl transferase, group 1: (5.6e-23); KEGG: ctc:CTC00268 mannosyltransferase, ev=2e-21, 26% identity YP_611226.1 PFAM: glycosyl transferase, group 1: (0.00036); KEGG: jan:Jann_2029 glycosyl transferase, group 1, ev=7e-59, 47% identity YP_611227.1 TIGRFAM: Type I secretion membrane fusion protein, HlyD: (2.4e-112); PFAM: secretion protein HlyD: (8.3e-33); KEGG: rru:Rru_B0040 type I secretion membrane fusion protein, HlyD, ev=3e-78, 39% identity YP_611228.1 KEGG: rru:Rru_B0039 type I secretion system ATPase, PrtD, ev=1e-152, 50% identity; TIGRFAM: Type I secretion system ATPase, PrtD: (7.7e-257); PFAM: ABC transporter, transmembrane region: (3.5e-12) ABC transporter related: (1.5e-59); SMART: ATPase: (1.8e-19) YP_611230.1 KEGG: rru:Rru_B0036 hypothetical protein, ev=1e-06, 45% identity YP_611231.1 PFAM: Methyltransferase type 11: (0.00031); KEGG: ccr:CC1017 hypothetical protein, ev=1e-152, 51% identity YP_611232.1 PFAM: Hemolysin-type calcium-binding region: (0.97); KEGG: tdn:Tmden_1726 hemolysin-type calcium-binding region, ev=1e-125, 33% identity YP_611234.1 PFAM: helix-turn-helix motif: (1.4e-07); KEGG: ccr:CC1006 transcriptional regulator, Cro/CI family, ev=8e-25, 57% identity YP_611235.1 KEGG: ccr:CC1005 hypothetical protein, ev=8e-14, 22% identity YP_611236.1 KEGG: ccr:CC1003 glyscosyl transferase, group 1 family protein, ev=6e-23, 27% identity YP_611237.1 PFAM: glycosyl transferase, group 1: (5.4e-26) Methyltransferase type 11: (3.3e-08); KEGG: syf:Synpcc7942_1902 putative glycosyltransferase, ev=2e-57, 36% identity YP_611238.1 PFAM: Methyltransferase type 11: (1.9e-12) Methyltransferase type 12: (3.1e-09); KEGG: psp:PSPPH_0956 WbbD, ev=2e-36, 41% identity YP_611239.1 PFAM: peptidase S8 and S53, subtilisin, kexin, sedolisin: (2.1e-45) Hemolysin-type calcium-binding region: (1.7) Proprotein convertase, P: (2.3e-10); KEGG: ana:all0364 similar to prohormone convertase, ev=1e-106, 39% identity YP_611240.1 PFAM: ABC transporter, transmembrane region: (4.8e-22) ABC transporter related: (5.6e-57); SMART: ATPase: (4.1e-19); KEGG: atc:AGR_L_552 probable ABC transporter ATP-binding protein Y4GM, ev=1e-157, 51% identity YP_611243.1 KEGG: sil:SPO0081 hypothetical protein, ev=2e-27, 34% identity YP_611245.1 KEGG: rru:Rru_B0036 hypothetical protein, ev=2e-10, 55% identity YP_611246.1 KEGG: sil:SPO0082 arabinose 5-phosphate isomerase, ev=8e-97, 60% identity; TIGRFAM: KpsF/GutQ family protein: (8.2e-118); PFAM: CBS: (5.1e-22) sugar isomerase (SIS): (9.7e-33) YP_611247.1 PFAM: DGPFAETKE: (2.2e-37); KEGG: rba:RB560 hypothetical protein, ev=2e-21, 46% identity YP_611248.1 PFAM: sigma-70 region 2: (2.9e-08) Sigma-70, region 4 type 2: (7.9e-08); KEGG: sma:SAV1195 putative RNA polymerase ECF-subfamily sigma factor, ev=2e-76, 44% identity YP_611249.1 KEGG: cvi:CV0374 hypothetical protein, ev=4e-36, 35% identity YP_611250.1 PFAM: glycosyl transferase, group 1: (1.7e-16); KEGG: jan:Jann_0078 glycosyl transferase, group 1, ev=1e-152, 63% identity YP_611251.1 TIGRFAM: glucose-1-phosphate thymidylyltransferase: (9.4e-165); PFAM: Nucleotidyl transferase: (4.1e-106); KEGG: jan:Jann_3841 glucose-1-phosphate thymidylyltransferase, ev=1e-124, 77% identity YP_611252.1 PFAM: NAD-dependent epimerase/dehydratase: (1.7e-11) polysaccharide biosynthesis protein CapD: (0.0038) dTDP-4-dehydrorhamnose reductase: (4.9e-136) Male sterility-like: (0.00025); KEGG: jan:Jann_3842 dTDP-4-dehydrorhamnose reductase, ev=2e-90, 61% identity YP_611253.1 TIGRFAM: dTDP-glucose 4,6-dehydratase: (1.1e-216); PFAM: NAD-dependent epimerase/dehydratase: (3e-96) short-chain dehydrogenase/reductase SDR: (4e-05) 3-beta hydroxysteroid dehydrogenase/isomerase: (3.9e-09) polysaccharide biosynthesis protein CapD: (2.7e-05) dTDP-4-dehydrorhamnose reductase: (1.7e-07) Male sterility-like: (2.5e-08); KEGG: jan:Jann_3843 dTDP-glucose 4,6-dehydratase, ev=1e-150, 72% identity YP_611254.1 PFAM: acyltransferase 3: (7.7e-36); KEGG: ade:Adeh_1161 acyltransferase 3, ev=2e-46, 36% identity YP_611255.1 KEGG: jan:Jann_3844 dTDP-4-dehydrorhamnose 3,5-epimerase, ev=1e-69, 63% identity; TIGRFAM: dTDP-4-dehydrorhamnose 3,5-epimerase: (2.3e-77); PFAM: dTDP-4-dehydrorhamnose 3,5-epimerase related: (2.4e-95) YP_611256.1 PFAM: PfkB: (4e-38); KEGG: jan:Jann_2574 PfkB, ev=3e-69, 51% identity YP_611257.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_611258.1 PFAM: Mannitol dehydrogenase-like: (1.3e-74) Mannitol dehydrogenase rossman-like: (3e-32); KEGG: spt:SPA1347 putative mannitol dehydrogenase, ev=6e-94, 41% identity YP_611259.1 PFAM: glycoside hydrolase, family 31: (1.1e-156); KEGG: ypm:YP3545 putative glucosidase, ev=0.0, 55% identity YP_611260.1 TIGRFAM: TRAP dicarboxylate transporter- DctM subunit: (1.3e-178); PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (5.2e-157); KEGG: vpa:VPA1704 putative integral membrane protein, possible transporter, ev=1e-170, 69% identity YP_611261.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component: (4.7e-29); KEGG: vpa:VPA1703 putative small integral C4-dicarboxylate membrane transport protein, ev=3e-42, 55% identity YP_611262.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit: (5.3e-68); PFAM: TRAP dicarboxylate transporter- DctP subunit: (1.4e-79); KEGG: vvy:VVA1590 TRAP-type C4-dicarboxylate transport system, periplasmic component, ev=4e-95, 56% identity YP_611263.1 PFAM: glycoside hydrolase family 2, immunoglobulin-like beta-sandwich: (0.011) glycoside hydrolase family 2, TIM barrel: (3.2e-13) glycoside hydrolase family 2, sugar binding: (1.7e-30); KEGG: sso:SSO3036 beta-glucuronidase, ev=2e-54, 29% identity YP_611264.1 PFAM: regulatory protein GntR, HTH: (3.9e-20) GntR-like: (2.2e-32); KEGG: vpa:VPA1701 putative transcriptional regulatory protein, ev=2e-72, 57% identity YP_611265.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_611268.1 KEGG: sil:SPO1791 sulfate/tungstate uptake family ABC transporter, periplasmic substrate-binding protein, ev=4e-45, 66% identity YP_611269.1 TIGRFAM: Excisionase/Xis, DNA-binding: (5.5e-07); KEGG: mag:amb2274 periplasmic molybdate-binding protein/domain, ev=8e-51, 39% identity YP_611270.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.4e-19); KEGG: sil:SPO3618 sulfonate ABC transporter, permease protein, , ev=1e-112, 80% identity YP_611271.1 PFAM: ABC transporter related: (3.8e-50); SMART: ATPase: (4.1e-17); KEGG: bms:BRA0468 ABC transporter, ATP-binding protein, ev=1e-105, 73% identity YP_611272.1 KEGG: sil:SPO3620 sulfonate ABC transporter, periplamic sulfonate-binding protein, ev=1e-119, 66% identity YP_611273.1 PFAM: regulatory protein GntR, HTH: (1.2e-13); KEGG: jan:Jann_4140 transcriptional regulator, GntR family, ev=2e-27, 37% identity YP_611274.1 PFAM: extracellular solute-binding protein, family 3: (1.9e-74); KEGG: ppr:PBPRA0007 amino acid ABC transporter, periplasmic amino acid-binding portion, ev=6e-74, 57% identity YP_611275.1 TIGRFAM: Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine: (3e-25); PFAM: binding-protein-dependent transport systems inner membrane component: (4.1e-22); KEGG: vch:VC0009 polar amino acid transport system permease protein, ev=6e-68, 62% identity YP_611276.1 PFAM: ABC transporter related: (9.1e-62); SMART: ATPase: (1.9e-19); KEGG: vch:VC0008 polar amino acid transport system ATP-binding protein, ev=4e-85, 65% identity YP_611277.1 PFAM: Hemolysin-type calcium-binding region: (0.00069); KEGG: sil:SPO1626 type I secretion target repeat protein, ev=1e-109, 31% identity YP_611278.1 PFAM: PfkB: (1.8e-27); KEGG: jan:Jann_2674 PfkB, ev=2e-95, 59% identity YP_611280.1 PFAM: protein of unknown function DUF1625: (2.9e-35); KEGG: mlo:mll2895 hypothetical protein, ev=2e-63, 35% identity YP_611284.1 KEGG: ppu:PP2506 hypothetical protein, ev=1e-08, 30% identity YP_611285.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.0035); PFAM: extracellular solute-binding protein, family 5: (5.2e-44); KEGG: sil:SPO3049 dipeptide ABC transporter, periplasmic dipeptide-binding protein, ev=0.0, 56% identity YP_611286.1 PFAM: Taurine catabolism dioxygenase TauD/TfdA: (1.8e-54); KEGG: mpa:MAP0238c alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase, ev=1e-57, 40% identity YP_611287.1 PFAM: FAD linked oxidase-like: (6.9e-27); KEGG: ret:RHE_CH02042 FAD linked oxidase protein, ev=1e-88, 39% identity YP_611288.1 PFAM: amidohydrolase: (0.00015) Amidohydrolase 3: (0.00056); KEGG: jan:Jann_1474 amidohydrolase 3, ev=2e-43, 32% identity YP_611289.1 PFAM: Creatininase: (4.9e-29); KEGG: mlo:mlr1298 creatinine amidohydrolase, , ev=6e-46, 39% identity YP_611290.1 KEGG: sme:SMc03236 glutamine amidotransferase, ev=4e-30, 34% identity YP_611291.1 PFAM: Endoribonuclease L-PSP: (3.1e-10); KEGG: jan:Jann_1470 endoribonuclease L-PSP, ev=7e-34, 56% identity YP_611293.1 KEGG: sil:SPO0300 hypothetical protein, ev=2e-50, 67% identity YP_611294.1 PFAM: beta-lactamase-like: (1e-23); KEGG: sil:SPO0299 metallo-beta-lactamase family protein, ev=1e-166, 83% identity YP_611295.1 PFAM: acyl-CoA dehydrogenase-like: (1.2e-34) Acyl-CoA dehydrogenase, type 2-like: (2.5e-06); KEGG: sil:SPO0298 acyl-CoA dehydrogenase family protein, ev=0.0, 78% identity YP_611296.1 TIGRFAM: Sua5/YciO/YrdC/YwlC: (2.8e-70); PFAM: SUA5: (6.6e-23) SUA5/yciO/yrdC-like: (8.5e-59); KEGG: sil:SPO0297 Sua5/YciO/YrdC family protein, ev=1e-121, 72% identity YP_611297.1 TIGRFAM: phage SPO1 DNA polymerase-related protein: (5.6e-65); PFAM: Uracil-DNA glycosylase superfamily: (5e-31); KEGG: sil:SPO0288 uracil-DNA glycosylase, ev=3e-96, 67% identity YP_611298.1 PFAM: metallophosphoesterase: (6.1e-09); KEGG: sil:SPO0289 Ser/Thr protein phosphatase family protein, ev=6e-67, 63% identity YP_611299.1 PFAM: Lysine exporter protein (LYSE/YGGA): (1.9e-31); KEGG: sil:SPO0290 transmembrane amino acid efflux protein, ev=1e-64, 63% identity YP_611300.1 TIGRFAM: Molybdenum cofactor biosynthesis protein B, proteobacteria: (2.6e-101); PFAM: molybdopterin binding domain: (2.2e-36); KEGG: sil:SPO0291 molybdenum cofactor biosynthesis protein B, ev=3e-84, 83% identity YP_611301.1 PFAM: secretion protein HlyD: (0.00049); KEGG: sil:SPO0292 efflux transporter, RND family, MFP subunit, ev=1e-147, 58% identity YP_611302.1 PFAM: acriflavin resistance protein: (1.2e-39); KEGG: sil:SPO0293 transporter, AcrB/AcrD/AcrF family, ev=0.0, 74% identity YP_611303.1 PFAM: NUDIX hydrolase: (2.2e-22); KEGG: bur:Bcep18194_A5292 NUDIX hydrolase, ev=5e-24, 40% identity YP_611304.1 KEGG: sil:SPO0295 hypothetical protein, ev=4e-81, 56% identity YP_611305.1 PFAM: protein of unknown function DUF179: (1.5e-86); KEGG: sil:SPO0296 transcriptional regulator, ev=2e-58, 63% identity YP_611306.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_611307.1 KEGG: sil:SPO0286 hypothetical protein, ev=2e-28, 45% identity YP_611308.1 TIGRFAM: dihydroorotase, multifunctional complex type: (2.5e-78); PFAM: amidohydrolase: (1.5e-08); KEGG: sil:SPO0284 dihydroorotase, multifunctional complex type, ev=0.0, 84% identity YP_611309.1 PFAM: protein of unknown function DUF205: (1.7e-50); KEGG: sil:SPO0283 conserved hypothetical protein TIGR00023, ev=3e-76, 67% identity YP_611310.1 KEGG: sil:SPO0281 hypothetical protein, ev=9e-60, 70% identity YP_611312.1 TIGRFAM: glutamate--cysteine ligase: (1.6e-259); PFAM: glutamate--cysteine ligase, GCS2: (7.6e-121); KEGG: sil:SPO3626 glutamate--cysteine ligase, ev=0.0, 84% identity YP_611313.1 KEGG: sil:SPO3627 hypothetical protein, ev=4e-51, 57% identity YP_611314.1 PFAM: GCN5-related N-acetyltransferase: (0.0033); KEGG: sil:SPO3628 acetyltransferase, GNAT family, ev=3e-45, 38% identity YP_611315.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_611316.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin YP_611317.1 PFAM: OmpA/MotB: (3e-26); KEGG: sil:SPO3631 OmpA domain protein, ev=0.0, 58% identity YP_611318.1 KEGG: sil:SPO3632 hypothetical protein, ev=6e-45, 90% identity YP_611319.1 KEGG: sil:SPO1334 hypothetical protein, ev=1e-23, 47% identity YP_611320.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_611321.1 KEGG: sil:SPOA0293 CDP-diacylglycerol--serine O-phosphatidyltransferase, ev=4e-76, 53% identity; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase: (3.8e-30); PFAM: CDP-alcohol phosphatidyltransferase: (1e-23) YP_611322.1 PFAM: UbiE/COQ5 methyltransferase: (0.00018) Methyltransferase type 11: (1.4e-31) Methyltransferase type 12: (2.3e-20); KEGG: sil:SPOA0294 phosphatidylethanolamine N-methyltransferase, ev=5e-71, 62% identity YP_611323.1 KEGG: sil:SPO3333 hypothetical protein, ev=1e-61, 41% identity YP_611324.1 lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse; lipoate-protein ligase B; transfers lipoate to apolipoproteins; involved in lipoate metabolism YP_611325.1 PFAM: GAF: (5.8e-05) ATP-binding region, ATPase-like: (1.4e-25) histidine kinase A-like: (4.9e-06) Phytochrome, central region: (6.4e-12) PAS fold-2: (1.7e-05); KEGG: rpb:RPB_4450 multi-sensor signal transduction histidine kinase, ev=1e-82, 32% identity YP_611326.1 PFAM: Haem oxygenase: (0.00097) YP_611327.1 PFAM: nitrogen-fixing NifU-like: (4.2e-31); KEGG: sil:SPO0382 NifU domain protein, ev=2e-93, 89% identity YP_611328.1 PFAM: peptidase M22, glycoprotease: (1.6e-33); KEGG: rsp:RSP_2213 hypothetical protein, ev=2e-55, 58% identity YP_611329.1 PFAM: GCN5-related N-acetyltransferase: (2.9e-11); KEGG: sil:SPO0380 ribosomal-protein-alanine acetyltransferase, , ev=2e-36, 55% identity YP_611330.1 PFAM: basic membrane lipoprotein: (3.3e-58); KEGG: sil:SPO0379 sugar ABC transporter, periplasmic sugar-binding protein, ev=1e-147, 77% identity YP_611331.1 PFAM: ABC transporter related: (1.5e-15); SMART: ATPase: (0.0062); KEGG: sil:SPO0378 sugar ABC transporter, ATP-binding protein, ev=0.0, 85% identity YP_611332.1 PFAM: inner-membrane translocator: (3.3e-43); KEGG: sil:SPO0377 sugar ABC transporter, permease protein, ev=1e-167, 78% identity YP_611333.1 PFAM: inner-membrane translocator: (2.6e-34); KEGG: sil:SPO0376 sugar ABC transporter, permease protein, ev=1e-141, 76% identity YP_611334.1 PFAM: protein of unknown function DUF81: (9.7e-36); KEGG: sil:SPO0375 membrane protein, ev=1e-135, 80% identity YP_611335.1 KEGG: sil:SPO0374 hypothetical protein, ev=4e-89, 65% identity YP_611336.1 PFAM: NAD-dependent epimerase/dehydratase: (0.00068) short-chain dehydrogenase/reductase SDR: (1.5e-24); KEGG: jan:Jann_0846 short-chain dehydrogenase/reductase SDR, ev=1e-75, 61% identity YP_611337.1 SMART: ATPase: (9.9e-06); KEGG: sil:SPO0373 helicase, ATP-dependent, , ev=0.0, 89% identity YP_611338.1 PFAM: regulatory protein, LuxR: (1.5e-08) Autoinducer-binding: (2.6e-19); KEGG: sil:SPO0371 autoinducer-binding transcriptional regulator LuxR, ev=1e-71, 51% identity YP_611340.1 TIGRFAM: Crotonyl-CoA reductase: (1.1e-271); PFAM: Alcohol dehydrogenase, zinc-binding: (1.8e-33) Alcohol dehydrogenase GroES-like: (2.6e-15); KEGG: sil:SPO0370 crotonyl-CoA reductase, ev=0.0, 91% identity YP_611341.1 PFAM: phospholipid/glycerol acyltransferase: (3.4e-12); KEGG: sil:SPO0369 acyltransferase family protein, ev=1e-166, 64% identity YP_611342.1 KEGG: sil:SPO0368 methylmalonyl-CoA mutase, ev=0.0, 86% identity; TIGRFAM: methylmalonyl-CoA mutase N-terminal domain: (2e-121) methylmalonyl-CoA mutase C-terminal domain: (1.7e-32); PFAM: methylmalonyl-CoA mutase: (5e-96) cobalamin B12-binding: (2.9e-26) YP_611343.1 PFAM: histone-like nucleoid-structuring protein H-NS: (1.2e-25); KEGG: sil:SPO0367 DNA-binding protein, H-NS family, ev=2e-31, 63% identity YP_611344.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_611345.1 KEGG: sil:SPO0365 hypothetical protein, ev=1e-137, 80% identity YP_611346.1 PFAM: Orn/DAP/Arg decarboxylase 2: (3.5e-28); KEGG: sil:SPO0364 decarboxylase, pyridoxal-dependent, ev=1e-157, 70% identity YP_611347.1 PFAM: regulatory protein, LysR: (2.8e-21) LysR, substrate-binding: (7.3e-19); KEGG: reu:Reut_B4718 regulatory protein, LysR:LysR, substrate-binding, ev=7e-47, 36% identity YP_611348.1 PFAM: extracellular solute-binding protein, family 5: (4.1e-60); KEGG: pst:PSPTO2576 peptide ABC transporter, periplasmic peptide-binding protein, ev=6e-96, 38% identity YP_611349.1 PFAM: binding-protein-dependent transport systems inner membrane component: (6.4e-54); KEGG: pst:PSPTO2575 peptide ABC transporter, permease protein, ev=1e-89, 50% identity YP_611350.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.1e-40); KEGG: psb:Psyr_2265 binding-protein-dependent transport systems inner membrane component, ev=9e-81, 48% identity YP_611351.1 KEGG: eba:ebA5654 ABC transporter, ATP-binding protein, ev=1e-164, 48% identity; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein-like: (9.3e-30); PFAM: ABC transporter related: (1.8e-69) Oligopeptide/dipeptide ABC transporter-like: (2.8e-28); SMART: ATPase: (3.2e-23) YP_611352.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_611353.1 KEGG: sme:SMb21041 conserved protein, possibly related to processing of cell wall amino acids, ev=2e-33, 29% identity YP_611354.1 PFAM: phage integrase: (7e-05); KEGG: bps:BPSL0587 phage integrase family protein, ev=2e-64, 54% identity YP_611358.1 KEGG: bja:blr2115 hypothetical protein, ev=2e-58, 34% identity YP_611360.1 KEGG: spn:SP1145 hypothetical protein, ev=3e-18, 30% identity YP_611362.1 PFAM: Integrase, catalytic region: (4.6e-37); KEGG: mlo:mll6088 transposase, ev=1e-117, 75% identity YP_611363.1 PFAM: transposase IS3/IS911: (2.9e-19); KEGG: ret:RHE_PA00090 probable insertion sequence transposase protein, IS3/IS911 family, ev=2e-34, 77% identity YP_611364.1 PFAM: regulatory protein, LacI: (2.3e-06) periplasmic binding protein/LacI transcriptional regulator: (2.2e-12); KEGG: sil:SPO3684 transcriptional regulator, LacI family, ev=1e-163, 85% identity YP_611365.1 PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (4.9e-94); KEGG: sil:SPO3695 TRAP dicarboxylate transporter, DctM subunit, , ev=0.0, 82% identity YP_611366.1 KEGG: sil:SPO3694 hypothetical protein, ev=3e-67, 63% identity YP_611367.1 PFAM: TRAP dicarboxylate transporter- DctP subunit: (2.4e-31); KEGG: sil:SPO3693 TRAP dicarboxylate transporter, DctP subunit, ev=1e-153, 75% identity YP_611368.1 TIGRFAM: GGDEF domain: (6.5e-31); PFAM: GGDEF: (5.2e-30) EAL: (6.7e-109); KEGG: mag:amb4494 predicted signal transduction protein containing a membrane domain, ev=8e-90, 35% identity YP_611369.1 PFAM: sulfatase: (2.6e-20) type I phosphodiesterase/nucleotide pyrophosphatase: (7.2e-05); KEGG: sil:SPO1083 choline sulfatase, ev=0.0, 80% identity YP_611370.1 PFAM: flagellin-like: (2.7e-06); KEGG: bmb:BruAb2_1084 flagellin family protein, ev=6e-47, 41% identity YP_611371.1 PFAM: Di-haem cytochrome c peroxidase: (1.5e-48); KEGG: bja:blr1552 methylamine utilization protein precursor, ev=2e-64, 43% identity YP_611372.1 TIGRFAM: GGDEF domain: (4.6e-39); PFAM: GGDEF: (1.7e-56) EAL: (3.4e-80) histidine kinase, HAMP region: (6.2e-12); KEGG: ret:RHE_CH02277 sensory box/GGDEF family protein, ev=3e-86, 40% identity YP_611373.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase: (3e-41) FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (0.003); KEGG: jan:Jann_1528 NADH:flavin oxidoreductase/NADH oxidase, ev=0.0, 80% identity YP_611374.1 PFAM: regulatory protein, TetR: (0.00091); KEGG: sil:SPO0168 transcriptional regulator, TetR family, ev=4e-63, 59% identity YP_611375.1 KEGG: bja:bll2873 ABC transporter ATP-binding protein, ev=3e-97, 58% identity; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein-like: (5.7e-30); PFAM: ABC transporter related: (1.1e-53) Oligopeptide/dipeptide ABC transporter-like: (2.1e-31); SMART: ATPase: (4.9e-18) YP_611376.1 KEGG: bja:bll2874 ABC transporter ATP-binding protein, ev=1e-115, 65% identity; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein-like: (3.8e-26); PFAM: ABC transporter related: (3.8e-62) Oligopeptide/dipeptide ABC transporter-like: (9.6e-26); SMART: ATPase: (1.3e-15) YP_611377.1 PFAM: binding-protein-dependent transport systems inner membrane component: (3e-42); KEGG: jan:Jann_2825 binding-protein-dependent transport systems inner membrane component, ev=1e-135, 76% identity YP_611378.1 PFAM: binding-protein-dependent transport systems inner membrane component: (3.6e-46); KEGG: jan:Jann_2824 binding-protein-dependent transport systems inner membrane component, ev=1e-136, 74% identity YP_611379.1 PFAM: extracellular solute-binding protein, family 5: (1.5e-69); KEGG: jan:Jann_2822 extracellular solute-binding protein, family 5, ev=0.0, 65% identity YP_611380.1 PFAM: extracellular solute-binding protein, family 5: (5.8e-70); KEGG: jan:Jann_2819 extracellular solute-binding protein, family 5, ev=0.0, 64% identity YP_611381.1 KEGG: jan:Jann_4169 hypothetical protein, ev=9e-66, 59% identity YP_611382.1 PFAM: aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding: (7.8e-06); KEGG: jan:Jann_4168 twin-arginine translocation pathway signal, ev=0.0, 50% identity YP_611383.1 PFAM: ferredoxin: (5.3e-08) [2Fe-2S]-binding: (6.6e-39); KEGG: jan:Jann_4167 (2Fe-2S)-binding, ev=4e-64, 76% identity YP_611384.1 KEGG: jan:Jann_1361 N-acetylglucosamine-6-phosphate deacetylase, ev=3e-99, 55% identity; TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase: (4e-66); PFAM: amidohydrolase: (0.00092) YP_611385.1 PFAM: sugar isomerase (SIS): (4.8e-08); KEGG: jan:Jann_1360 glutamine-fructose-6-phosphate transaminase (isomerizing), ev=1e-112, 62% identity YP_611386.1 PFAM: regulatory protein GntR, HTH: (1e-18) UbiC transcription regulator-associated: (2.7e-46); KEGG: sil:SPO1842 transcriptional regulator, GntR family, ev=3e-80, 61% identity YP_611387.1 PFAM: ATPase, BadF/BadG/BcrA/BcrD type: (1.3e-13); KEGG: jan:Jann_1358 ATPase, BadF/BadG/BcrA/BcrD type, ev=5e-62, 42% identity YP_611388.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_611389.1 PFAM: extracellular solute-binding protein, family 1: (7.3e-19); KEGG: sil:SPO1839 sugar ABC transporter, periplasmic sugar-binding protein, ev=0.0, 77% identity YP_611390.1 PFAM: binding-protein-dependent transport systems inner membrane component: (0.00056); KEGG: sil:SPO1838 sugar ABC transporter, permease protein, ev=1e-152, 86% identity YP_611391.1 PFAM: binding-protein-dependent transport systems inner membrane component: (2.3e-14); KEGG: sil:SPO1837 sugar ABC transporter, permease protein, ev=1e-141, 91% identity YP_611392.1 PFAM: oxidoreductase-like: (4e-25) dihydrodipicolinate reductase: (0.00054) homoserine dehydrogenase, NAD-binding: (0.00038); KEGG: sil:SPO1836 oxidoreductase, Gfo/Idh/MocA family, ev=1e-160, 80% identity YP_611393.1 PFAM: ABC transporter related: (4.1e-54) Transport-associated OB: (7.5e-06); SMART: ATPase: (1.2e-16); KEGG: jan:Jann_1353 ABC transporter related, ev=1e-130, 69% identity YP_611394.1 PFAM: regulatory protein, TetR: (2.4e-07); KEGG: sil:SPO1082 HTH-type transcriptional regulator BetI, ev=1e-44, 49% identity YP_611395.1 KEGG: sil:SPO2161 hypothetical protein, ev=2e-35, 35% identity YP_611396.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_611397.1 PFAM: helix-turn-helix, AraC type: (1e-07) transcription activator, effector binding: (9.1e-39); KEGG: sil:SPO3615 transcriptional regulator, AraC family, ev=1e-101, 64% identity YP_611398.1 PFAM: Lysine exporter protein (LYSE/YGGA): (0.00023); KEGG: sil:SPO3613 transporter, LysE family, ev=1e-86, 78% identity YP_611399.1 PFAM: regulatory proteins, AsnC/Lrp: (1.7e-22); KEGG: sil:SPO3612 transcriptional regulator, AsnC family, ev=6e-63, 79% identity YP_611400.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (0.00019); KEGG: sil:SPO0917 glyoxalase family protein, ev=2e-33, 57% identity YP_611401.1 PFAM: HpcH/HpaI aldolase: (7.3e-36); KEGG: sil:SPO3608 malyl-CoA lyase, ev=1e-164, 90% identity YP_611402.1 PFAM: protein of unknown function DUF1611: (1.9e-125); KEGG: sil:SPO3607 hypothetical protein, ev=1e-158, 81% identity YP_611403.1 PFAM: Mandelate racemase/muconate lactonizing enzyme-like: (8.1e-17); KEGG: sil:SPO3606 mandelate racemase/muconate lactonizing enzyme family protein, ev=1e-151, 84% identity YP_611404.1 PFAM: aminotransferase, class IV: (1.3e-66); KEGG: sil:SPO3604 D-amino acid aminotransferase, , ev=1e-140, 86% identity YP_611405.1 PFAM: Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B: (4e-74); KEGG: aci:ACIAD2249 hypothetical protein, ev=1e-74, 51% identity YP_611406.1 PFAM: protein of unknown function DUF1244: (1e-44); KEGG: sil:SPO3602 hypothetical protein, ev=1e-41, 77% identity YP_611407.1 TIGRFAM: K+-dependent Na+/Ca+ exchanger related-protein: (4.5e-76); PFAM: sodium/calcium exchanger membrane region: (2.2e-39); KEGG: son:SO0354 sodium/calcium exchanger, ev=2e-66, 46% identity YP_611408.1 PFAM: ASPIC/UnbV: (2.9e-15); KEGG: sil:SPO0859 FG-GAP repeat domain protein, ev=0.0, 63% identity YP_611409.1 PFAM: ROK: (9.8e-29); KEGG: sil:SPO0860 xylose repressor, , ev=1e-115, 55% identity YP_611410.1 TIGRFAM: D-xylose ABC transporter, substrate-binding protein: (8.3e-198); PFAM: periplasmic binding protein/LacI transcriptional regulator: (0.0017); KEGG: sil:SPO0861 xylose ABC transporter, periplasmic xylose-binding protein, ev=1e-156, 81% identity YP_611411.1 PFAM: inner-membrane translocator: (1.2e-50); KEGG: sil:SPO0862 xylose ABC transporter, permease protein, ev=0.0, 76% identity YP_611412.1 PFAM: ABC transporter related: (8.4e-52); SMART: ATPase: (5.6e-17); KEGG: sil:SPO0863 xylose ABC transporter, ATP-binding protein, ev=1e-117, 86% identity YP_611413.1 PFAM: histidine kinase, HAMP region: (1.7e-07) Cache: (4.3e-12) chemotaxis sensory transducer: (1.7e-77); KEGG: ret:RHE_CH00974 methyl-accepting chemotaxis protein, ev=1e-176, 46% identity YP_611414.1 PFAM: Extracellular ligand-binding receptor: (1e-11); KEGG: bja:blr6548 probable leucine/isoleucine/valine-binding protein precursor, ev=1e-100, 53% identity YP_611415.1 PFAM: histidine kinase, HAMP region: (1.5e-06) chemotaxis sensory transducer: (1.7e-79); KEGG: ccr:CC0430 methyl-accepting chemotaxis protein McpA, ev=5e-99, 46% identity YP_611416.1 KEGG: sil:SPO1053 hypothetical protein, ev=1e-45, 58% identity YP_611417.1 PFAM: regulatory protein, LuxR: (2.4e-05); KEGG: sil:SPO2286 autoinducer-binding transcriptional regulator LuxR, ev=5e-07, 23% identity YP_611418.1 KEGG: rsp:RSP_3350 lipocalin-related protein, ev=2e-10, 23% identity YP_611420.1 PFAM: protein of unknown function DUF6, transmembrane: (1.5e-20); KEGG: bur:Bcep18194_B1695 protein of unknown function DUF6, transmembrane, ev=8e-81, 57% identity YP_611421.1 PFAM: regulatory protein, LysR: (1.7e-22) LysR, substrate-binding: (1.4e-43); KEGG: pfl:PFL_3389 transcriptional regulator, LysR family, ev=7e-78, 51% identity YP_611422.1 PFAM: regulatory protein, LysR: (2.3e-23); KEGG: sil:SPO0639 transcriptional regulator, LysR family, ev=2e-59, 45% identity YP_611423.1 PFAM: metal-dependent phosphohydrolase, HD subdomain: (3.9e-05); KEGG: sil:SPO0638 hypothetical protein, ev=5e-80, 68% identity YP_611424.1 PFAM: regulatory protein, LysR: (2.8e-13) LysR, substrate-binding: (1.7e-27); KEGG: sil:SPO3301 transcriptional regulator, LysR family, ev=5e-78, 51% identity YP_611425.1 KEGG: sil:SPO3302 hypothetical protein, ev=7e-18, 47% identity YP_611426.1 TIGRFAM: formate dehydrogenase, alpha subunit: (1.1e-256); PFAM: ferredoxin: (0.0011) 4Fe-4S ferredoxin, iron-sulfur binding: (9.6e-06) molybdopterin oxidoreductase: (2.5e-108) molydopterin dinucleotide-binding region: (2.4e-41) molybdopterin oxidoreductase Fe4S4 region: (3.7e-22); KEGG: sil:SPO0834 formate dehydrogenase, alpha subunit, ev=0.0, 75% identity YP_611427.1 PFAM: NADH dehydrogenase (ubiquinone), 24 kDa subunit: (9.3e-09) Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit: (1.4e-90); KEGG: sil:SPO0833 formate dehydrogenase, beta subunit, ev=0.0, 82% identity YP_611428.1 PFAM: LysR, substrate-binding: (1.3e-27); KEGG: sil:SPO0832 transcriptional regulator, LysR family, ev=3e-81, 57% identity YP_611429.1 KEGG: vch:VCA0032 hypothetical protein, ev=6e-40, 44% identity YP_611430.1 PFAM: histidine kinase, HAMP region: (4.6e-09) chemotaxis sensory transducer: (1.5e-81); KEGG: ccr:CC0343 methyl-accepting chemotaxis protein McpC, ev=2e-89, 42% identity YP_611431.1 PFAM: TRAP dicarboxylate transporter- DctP subunit: (2.7e-11); KEGG: dps:DP0483 DctP (periplasmic C4-dicarboxylate binding protein), ev=4e-25, 26% identity YP_611433.1 TIGRFAM: TRAP dicarboxylate transporter- DctM subunit: (1e-74); PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (4.4e-68); KEGG: dps:DP0487 DctM (C4-dicarboxylate permease, large subunit), ev=6e-88, 38% identity YP_611434.1 PFAM: dihydrodipicolinate synthetase: (1.2e-09); KEGG: sil:SPOA0267 dihydroxydipicolinate synthase family protein, ev=1e-158, 84% identity YP_611435.1 PFAM: proline racemase: (2.1e-89); KEGG: sil:SPOA0266 proline racemase, , ev=1e-113, 65% identity YP_611436.1 PFAM: FAD dependent oxidoreductase: (1.1e-74); KEGG: sil:SPOA0262 oxidoreductase, FAD-binding, ev=1e-158, 66% identity YP_611437.1 PFAM: proline racemase: (1.5e-190); KEGG: atc:AGR_L_395 hypothetical protein PA1255, ev=1e-155, 77% identity YP_611439.1 PFAM: response regulator receiver: (9.1e-15); KEGG: rsp:RSP_2433 chemotaxis response regulator, CheY2, ev=8e-40, 60% identity YP_611440.1 PFAM: MCP methyltransferase, CheR-type: (1.6e-78); KEGG: rsp:RSP_2434 MCP methyltransferase, CheR1, ev=4e-66, 46% identity YP_611441.1 PFAM: CheW-like protein: (3e-29); KEGG: ret:RHE_CH02831 chemotaxis signal transduction protein, ev=1e-30, 48% identity YP_611442.1 PFAM: CheW-like protein: (4.7e-21) ATP-binding region, ATPase-like: (1.5e-29) Signal transducing histidine kinase, homodimeric: (2.6e-16) Hpt: (6.3e-15); KEGG: ret:RHE_CH00639 chemotaxis two-component sensor histidine kinase protein, ev=0.0, 47% identity YP_611443.1 PFAM: response regulator receiver: (3.3e-28); KEGG: jan:Jann_2842 response regulator receiver domain protein (CheY-like), ev=4e-36, 61% identity YP_611445.1 PFAM: histidine kinase, HAMP region: (1.4e-12) chemotaxis sensory transducer: (1.1e-88); KEGG: ccr:CC0343 methyl-accepting chemotaxis protein McpC, ev=1e-95, 44% identity YP_611446.1 PFAM: CheB methylesterase: (1.7e-61); KEGG: jan:Jann_2844 CheB methylesterase, ev=4e-48, 40% identity YP_611447.1 PFAM: CheD: (2.5e-30); KEGG: atc:AGR_C_918 chemotaxis protein cheD, ev=1e-43, 51% identity YP_611448.1 PFAM: regulatory protein, TetR: (1.7e-10); KEGG: sil:SPOA0067 transcriptional regulator, TetR family, ev=4e-44, 42% identity YP_611449.1 PFAM: thiamine pyrophosphate enzyme-like TPP-binding: (1.2e-35) thiamine pyrophosphate enzyme, central region: (0.00021) thiamine pyrophosphate enzyme-like TPP binding region: (3.5e-47); KEGG: sil:SPOA0065 thiamine pyrophosphate-dependent enzyme, ev=1e-157, 56% identity YP_611450.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.7e-08); KEGG: bbr:BB4935 inner membrane component of binding-protein-dependent transport system, ev=1e-108, 69% identity YP_611451.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1e-09); KEGG: bbr:BB4934 inner membrane component of binding-protein-dependent transport system, ev=1e-107, 63% identity YP_611452.1 PFAM: extracellular solute-binding protein, family 1: (2.3e-28); KEGG: bbr:BB4933 probable extracellular solute-binding protein, ev=1e-143, 58% identity YP_611453.1 PFAM: ABC transporter related: (2e-58) TOBE: (3.9e-10) Transport-associated OB: (1.1e-12); SMART: ATPase: (2.1e-12); KEGG: bbr:BB4932 sugar ABC transporter, ATP-binding protein, ev=5e-94, 56% identity YP_611454.1 PFAM: ferredoxin: (4.1e-18) oxidoreductase FAD/NAD(P)-binding: (2.5e-15) Oxidoreductase FAD-binding region: (4.1e-06); KEGG: sme:SMa0752 possible dioxygenase reductase subunit, ev=1e-136, 64% identity YP_611455.1 PFAM: Rieske [2Fe-2S] region: (4.8e-22); KEGG: sme:SMa0751 aromatic-ring hydroxylating dioxygenase, alpha-subunit, ev=1e-169, 68% identity YP_611456.1 PFAM: TRAP dicarboxylate transporter- DctP subunit: (6.1e-10); KEGG: sil:SPO1814 TRAP dicarboxylate transporter, DctP subunit, , ev=1e-148, 78% identity YP_611457.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component: (1.8e-10); KEGG: sil:SPOA0239 TRAP dicarboxylate transporter, DctQ subunit, ev=6e-70, 62% identity YP_611458.1 PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (1.7e-58); KEGG: sil:SPO1816 TRAP dicarboxylate transporter, DctM subunit, , ev=0.0, 84% identity YP_611459.1 KEGG: cvi:CV0102 probable ABC transporter, periplasmic substrate-binding, ev=6e-37, 36% identity YP_611461.1 PFAM: von Willebrand factor, type A: (2e-06); KEGG: sil:SPO2221 von Willebrand factor type A domain protein, ev=3e-84, 41% identity YP_611463.1 PFAM: alpha/beta hydrolase fold: (0.00011) regulatory protein, LuxR: (4.5e-05); KEGG: sil:SPO1388 transcriptional regulator, LuxR family/hydrolase, alpha/beta fold family, ev=3e-31, 26% identity YP_611464.1 PFAM: helix-turn-helix, AraC type: (3.3e-06) AraC-type transcriptional regulator-like: (3.9e-33); KEGG: gsu:GSU3127 transcriptional regulator, AraC family, ev=4e-50, 43% identity YP_611465.1 PFAM: ferredoxin: (6.4e-12) [2Fe-2S]-binding: (5.1e-28); KEGG: sme:SMb20343 isoquinoline 1-oxidoreductase, alpha ubunit, ev=3e-51, 62% identity YP_611466.1 TIGRFAM: Twin-arginine translocation pathway signal: (6.2e-05); PFAM: aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding: (6e-08); KEGG: hch:HCH_01590 aerobic-type carbon monoxide dehydrogenase large subunit CoxL/CutL-like protein, ev=1e-167, 45% identity YP_611467.1 PFAM: response regulator receiver: (0.00049) ATP-binding region, ATPase-like: (7.1e-24) histidine kinase, HAMP region: (2.7e-14) histidine kinase A-like: (1.7e-06); KEGG: ypk:y3864 hypothetical protein, ev=1e-66, 26% identity YP_611468.1 PFAM: response regulator receiver: (4.5e-22) transcriptional regulatory protein-like: (1e-23); KEGG: pae:PA4983 probable two-component response regulator, ev=6e-45, 42% identity YP_611469.1 TIGRFAM: Phosphonate-binding periplasmic protein: (1.3e-71); KEGG: dde:Dde_3730 phosphonate-binding periplasmic protein, ev=5e-99, 59% identity YP_611470.1 KEGG: cyb:CYB_1467 phosphonate ABC transporter, ATP-binding protein, ev=4e-77, 56% identity; TIGRFAM: Phosphonate ABC transporter PhnC, ATP-binding: (3.6e-134); PFAM: ABC transporter related: (1.3e-62); SMART: ATPase: (1.5e-13) YP_611471.1 TIGRFAM: Phosphonate uptake transporter: (2.2e-36); PFAM: binding-protein-dependent transport systems inner membrane component: (1.1e-16); KEGG: cyb:CYB_1468 phosphonate ABC transporter, permease protein, ev=6e-67, 50% identity YP_611472.1 TIGRFAM: Phosphonate uptake transporter: (2.3e-40); PFAM: binding-protein-dependent transport systems inner membrane component: (2.6e-16); KEGG: rpb:RPB_1925 phosphonate uptake transporter, ev=4e-71, 50% identity YP_611473.1 PFAM: DSBA oxidoreductase: (1.5e-07); KEGG: efa:EF1088 hypothetical protein, ev=5e-24, 31% identity YP_611474.1 KEGG: xft:PD0713 hypothetical protein, ev=9e-58, 45% identity YP_611475.1 KEGG: sme:SMc02708 glutathione S-transferase, ev=5e-95, 57% identity YP_611476.1 PFAM: regulatory protein, LysR: (7.9e-20) LysR, substrate-binding: (1.6e-60); KEGG: vpa:VPA0216 transcription regulator protein, ev=2e-82, 48% identity YP_611478.1 PFAM: chemotaxis sensory transducer: (4.7e-59) PAS fold-3: (9.1e-12) PAS fold-4: (0.00012) PAS fold: (0.0014); SMART: PAS: (3.6e-05) PAC motif: (0.01); KEGG: bba:Bd2831 methyl-accepting chemotaxis protein, ev=1e-148, 45% identity YP_611479.1 PFAM: MCP methyltransferase, CheR-type: (9.6e-50); KEGG: bba:Bd2830 chemotaxis protein methyltransferase, ev=9e-56, 40% identity YP_611480.1 KEGG: bba:Bd2829 chemotaxis protein, ev=6e-14, 30% identity YP_611481.1 PFAM: CheW-like protein: (5.2e-16); KEGG: bba:Bd2828 purine-binding chemotaxis protein CheW, ev=6e-67, 29% identity YP_611482.1 PFAM: transposase IS3/IS911: (3.7e-16); KEGG: ret:RHE_PA00090 probable insertion sequence transposase protein, IS3/IS911 family, ev=3e-33, 76% identity YP_611483.1 PFAM: Integrase, catalytic region: (4.6e-37); KEGG: mlo:mll6088 transposase, ev=1e-117, 75% identity YP_611484.1 KEGG: mag:amb0914 transposase and inactivated derivative, ev=1e-09, 53% identity YP_611485.1 KEGG: deh:cbdb_A1487 transposase orfB, ev=1e-20, 59% identity YP_611486.1 PFAM: CBS: (3.4e-30); KEGG: sil:SPOA0034 CBS domain protein, ev=7e-46, 53% identity YP_611487.1 KEGG: sil:SPOA0035 hypothetical protein, ev=6e-08, 50% identity YP_611488.1 PFAM: inner-membrane translocator: (2.2e-60); KEGG: ppr:PBPRB0472 sugar ABC transporter (permease), ev=6e-58, 37% identity YP_611489.1 PFAM: ABC transporter related: (8.1e-30); SMART: ATPase: (2.3e-09); KEGG: sma:SAV5319 D-ribose ABC transporter ATP-binding protein, ev=1e-108, 44% identity YP_611490.1 periplasmic sensory protein associated with the TorRS two-component regulatory system YP_611491.1 PFAM: Allophanate hydrolase subunit 2: (1.2e-69); KEGG: bps:BPSS0194 hypothetical protein, ev=1e-105, 57% identity YP_611492.1 PFAM: Allophanate hydrolase subunit 1: (5.3e-09); KEGG: allophanate hydrolase, subunit 1, ev=1e-113, 64% identity YP_611493.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_611494.1 PFAM: biotin/lipoyl attachment: (3e-14); KEGG: pae:PA0493 acetyl-CoA carboxylase, ev=4e-13, 48% identity YP_611495.1 PFAM: LamB/YcsF: (4.5e-111); KEGG: LamB/YcsF family protein, ev=1e-89, 63% identity YP_611496.1 PFAM: regulatory protein, LysR: (4.3e-20) LysR, substrate-binding: (2.6e-48); KEGG: transcriptional regulator, LysR family, ev=4e-94, 59% identity YP_611497.1 PFAM: helix-turn-helix motif: (3.1e-15) Cupin 2, conserved barrel: (1.5e-20); KEGG: sil:SPOA0273 DNA-binding protein, , ev=9e-86, 81% identity YP_611498.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_611499.1 KEGG: sil:SPOA0275 succinate-semialdehyde dehydrogenase, ev=0.0, 80% identity; TIGRFAM: succinic semialdehyde dehydrogenase: (0); PFAM: aldehyde dehydrogenase: (8.3e-233) YP_611500.1 PFAM: ROK: (3.6e-30); KEGG: jan:Jann_0880 ROK, ev=1e-107, 51% identity YP_611501.1 PFAM: peptidase M20: (2.6e-23) peptidase dimerisation: (1.4e-05); KEGG: jan:Jann_0881 peptidase M20, ev=1e-138, 57% identity YP_611502.1 KEGG: jan:Jann_0882 periplasmic binding protein/LacI transcriptional regulator, ev=1e-145, 74% identity YP_611503.1 PFAM: inner-membrane translocator: (1e-57); KEGG: jan:Jann_0883 inner-membrane translocator, ev=1e-130, 77% identity YP_611504.1 KEGG: jan:Jann_0884 hypothetical protein, ev=1e-163, 71% identity YP_611505.1 PFAM: ABC transporter related: (2.9e-49); SMART: ATPase: (8.5e-19); KEGG: jan:Jann_0885 ABC transporter related, ev=1e-102, 78% identity YP_611506.1 PFAM: short-chain dehydrogenase/reductase SDR: (1.4e-30); KEGG: sil:SPO1015 3-hydroxybutyrate dehydrogenase, , ev=1e-104, 69% identity YP_611507.1 PFAM: AMP-dependent synthetase and ligase: (1e-106); KEGG: rpa:RPA3465 long-chain-fatty-acid CoA ligase, ev=1e-169, 60% identity YP_611508.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_611509.1 PFAM: regulatory protein, LuxR: (2.1e-21); SMART: PAS: (4.3e-06); KEGG: sil:SPO1012 transcriptional regulator, LuxR family, ev=1e-50, 54% identity YP_611511.1 KEGG: eli:ELI_14900 transposase orfB, ev=3e-15, 62% identity YP_611512.1 KEGG: deh:cbdb_A1487 transposase orfB, ev=2e-11, 48% identity YP_611513.1 PFAM: response regulator receiver: (3.4e-31) ATP-binding region, ATPase-like: (2.4e-41) histidine kinase A-like: (6.6e-26); KEGG: ccr:CC3102 sensor histidine kinase/response regulator, ev=8e-78, 44% identity YP_611515.1 KEGG: sil:SPO2951 hypothetical protein, ev=1e-17, 45% identity YP_611516.1 PFAM: protein of unknown function DUF6, transmembrane: (8.3e-09); KEGG: vpa:VPA1215 hypothetical protein, ev=1e-35, 31% identity YP_611517.1 TIGRFAM: 4-oxalocrotonate tautomerase family enzyme: (1.3e-16); PFAM: 4-oxalocrotonate tautomerase: (4.1e-18); KEGG: plu:plu0307 hypothetical protein, ev=5e-16, 54% identity YP_611518.1 KEGG: ccr:CC2974 hypothetical protein, ev=3e-19, 37% identity YP_611519.1 PFAM: regulatory protein, LysR: (1.2e-18) LysR, substrate-binding: (3.4e-27); KEGG: hch:HCH_06627 transcriptional regulator, ev=1e-38, 32% identity YP_611520.1 PFAM: NADPH-dependent FMN reductase: (0.0023); KEGG: reu:Reut_B4867 flavodoxin/nitric oxide synthase, ev=6e-58, 60% identity YP_611521.1 TIGRFAM: Outer membrane autotransporter barrel: (1.5e-11); PFAM: Autotransporter beta-domain: (1.7e-19); KEGG: spn:SP1772 cell wall surface anchor family protein, ev=2e-87, 21% identity YP_611522.1 PFAM: phage Tail Collar: (3.5e-20); KEGG: mlo:mll4443 microcystin dependent protein MdpB, ev=4e-50, 55% identity YP_611523.1 PFAM: phage Tail Collar: (4.3e-26); KEGG: hch:HCH_06045 microcystin-dependent protein, ev=2e-47, 51% identity YP_611524.1 PFAM: phage Tail Collar: (4.4e-20); KEGG: mlo:mll4441 microcystin dependent protein MdpB, ev=2e-48, 53% identity YP_611525.1 KEGG: cac:CAC3395 predicted membrane protein, ev=3e-09, 22% identity YP_611526.1 PFAM: GCN5-related N-acetyltransferase: (1.7e-08); KEGG: mlo:mll4440 contains weak similarity to acetyltransferase, ev=8e-45, 62% identity YP_611527.1 KEGG: mlo:mlr4438 hypothetical protein, ev=1e-08, 39% identity YP_611529.1 PFAM: helix-turn-helix, AraC type: (9.1e-05) ThiJ/PfpI: (6.7e-06); KEGG: atc:AGR_pAT_bx241 transcriptional regulator homolog (GlxA), ev=1e-58, 43% identity YP_611530.1 AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase YP_611531.1 PFAM: protein of unknown function DUF849: (8e-195); KEGG: jan:Jann_3825 protein of unknown function DUF849, ev=1e-148, 82% identity YP_611532.1 PFAM: BCCT transporter: (2.3e-102); KEGG: cps:CPS_4027 transporter, BCCT family, ev=1e-122, 48% identity YP_611533.1 TIGRFAM: PAS: (1e-08); PFAM: ATP-binding region, ATPase-like: (1.9e-28) histidine kinase, HAMP region: (0.00021) histidine kinase A-like: (5.9e-09) PAS fold-4: (0.0032); KEGG: son:SO0544 sensory box histidine kinase, ev=7e-56, 33% identity YP_611534.1 PFAM: response regulator receiver: (8.5e-14) ATP-binding region, ATPase-like: (3.8e-33) histidine kinase A-like: (0.00021); KEGG: ret:RHE_CH00624 probable two-component sensor histidine kinase/response regulator hybrid protein, ev=5e-45, 30% identity YP_611535.1 PFAM: Endoribonuclease L-PSP: (0.0046); KEGG: jan:Jann_2297 endoribonuclease L-PSP, ev=4e-24, 81% identity YP_611536.1 KEGG: neu:NE2446 transposase IS4 family, ev=2e-11, 51% identity YP_611537.1 PFAM: ABC transporter related: (1.9e-54) TOBE: (0.00078) Transport-associated OB: (8e-05); SMART: ATPase: (1.7e-16); KEGG: rsp:RSP_2870 ABC alpha-glucoside transporter, ATPase subunit AglK, ev=1e-141, 73% identity YP_611538.1 PFAM: alpha amylase, catalytic region: (4.1e-97); SMART: Alpha amylase, catalytic subdomain: (6.3e-132); KEGG: jan:Jann_1949 alpha amylase protein, ev=0.0, 72% identity YP_611539.1 PFAM: binding-protein-dependent transport systems inner membrane component: (2.3e-11); KEGG: rsp:RSP_2871 ABC alpha-glucoside transporter, inner membrane subunit AglG, ev=1e-139, 67% identity YP_611540.1 PFAM: binding-protein-dependent transport systems inner membrane component: (0.0022); KEGG: rsp:RSP_2872 ABC alpha-glucoside transporter, inner membrane subunit AglF, ev=1e-123, 67% identity YP_611541.1 PFAM: extracellular solute-binding protein, family 1: (0.013); KEGG: rsp:RSP_2873 ABC alpha-glucoside transporter, perplasmic substrate-binding protein, ev=0.0, 67% identity YP_611542.1 PFAM: periplasmic binding protein/LacI transcriptional regulator: (3.2e-09); SMART: regulatory protein, LacI: (1.3e-18); KEGG: jan:Jann_1945 transcriptional regulator, LacI family, ev=1e-107, 58% identity YP_611543.1 PFAM: glycoside hydrolase, family 1: (5.3e-161); KEGG: jan:Jann_1944 beta-glucosidase, ev=0.0, 69% identity YP_611544.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_611545.1 PFAM: regulatory protein, LacI: (6.5e-08) periplasmic binding protein/LacI transcriptional regulator: (2.2e-13); KEGG: bbr:BB4926 probable LacI-family transcriptional regulator, ev=4e-46, 32% identity YP_611546.1 KEGG: bbr:BB4927 probable periplasmic solute-binding protein, ev=1e-126, 62% identity YP_611547.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.5e-13); KEGG: rpa:RPA1477 permease protein, ev=3e-87, 61% identity YP_611548.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.3e-15); KEGG: rpa:RPA1478 permease protein, ev=5e-95, 68% identity YP_611549.1 PFAM: ABC transporter related: (3.8e-67) Transport-associated OB: (2.6e-10); SMART: ATPase: (3.3e-22); KEGG: rpa:RPA1479 transport system ATP-binding protein, ev=4e-86, 51% identity YP_611550.1 PFAM: metallophosphoesterase: (9.7e-16); KEGG: rpb:RPB_4042 metallophosphoesterase, ev=8e-46, 41% identity YP_611551.1 TIGRFAM: TRAP dicarboxylate transporter- DctM subunit: (1.1e-147); PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (3.2e-144); KEGG: vpa:VPA1704 integral membrane protein, possible transporter, ev=1e-92, 41% identity YP_611552.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component: (2.3e-27); KEGG: bbr:BB1743 hypothetical protein, ev=1e-16, 36% identity YP_611553.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit: (2.5e-87); PFAM: TRAP dicarboxylate transporter- DctP subunit: (8e-107); KEGG: bpe:BP2352 periplasmic substrate-binding transport protein, ev=5e-99, 55% identity YP_611554.1 PFAM: 6-phosphogluconate dehydrogenase, NAD-binding: (6.5e-47) NAD-dependent glycerol-3-phosphate dehydrogenase-like: (0.0005); KEGG: bja:bll6323 3-hydroxyisobutyrate dehydrogenase, ev=1e-107, 66% identity YP_611555.1 PFAM: aldehyde dehydrogenase: (3.9e-234); KEGG: mlo:mll2319 aldehyde dehydrogenase, ev=0.0, 75% identity YP_611557.1 PFAM: Malate/L-lactate dehydrogenase: (1e-35); KEGG: bma:BMAA1423 malate/L-lactate dehydrogenase family protein, ev=1e-100, 54% identity YP_611558.1 PFAM: regulatory protein GntR, HTH: (7.4e-21) GntR-like: (1.1e-10); KEGG: sil:SPOA0261 transcriptional regulator, GntR family, ev=2e-82, 68% identity YP_611559.1 PFAM: aldehyde dehydrogenase: (1.8e-16); KEGG: sil:SPOA0260 aldehyde dehydrogenase family protein, ev=0.0, 76% identity YP_611560.1 PFAM: Paraquat-inducible protein A: (1.7e-14); KEGG: jan:Jann_1569 paraquat-inducible protein A, ev=1e-42, 44% identity YP_611561.1 PFAM: Paraquat-inducible protein A: (4.3e-65); KEGG: jan:Jann_1570 paraquat-inducible protein A, ev=1e-59, 59% identity YP_611562.1 PFAM: Mammalian cell entry related: (5e-08); KEGG: sil:SPO1249 paraquat-inducible protein, , ev=1e-120, 36% identity YP_611563.1 PFAM: protein of unknown function DUF330: (2.3e-07); KEGG: jan:Jann_1572 protein of unknown function DUF330, ev=1e-21, 39% identity YP_611564.1 PFAM: ABC transporter related: (2.1e-69); SMART: ATPase: (4.6e-21); KEGG: sdy:SDY_2618 ATP-binding component of sulfate permease A protein, ev=3e-69, 57% identity YP_611565.1 TIGRFAM: Sulphate transport system permease protein 2: (2.3e-104) Sulfate ABC transporter, permease protein CysW: (6.8e-129); PFAM: binding-protein-dependent transport systems inner membrane component: (3.7e-11); KEGG: rsp:RSP_3699 ABC sulfate/thiosulfate transporter, inner membrane subunit CysW, ev=1e-81, 57% identity YP_611566.1 TIGRFAM: Sulphate transport system permease protein 2: (5.5e-119) Sulfate ABC transporter, permease protein CysT: (1.2e-138); PFAM: binding-protein-dependent transport systems inner membrane component: (1.4e-28); KEGG: sgl:SG1708 sulfate ABC transporter permease component CysT, ev=4e-88, 60% identity YP_611567.1 TIGRFAM: Thiosulphate-binding protein: (6.3e-160); PFAM: extracellular solute-binding protein, family 1: (0.016); KEGG: bmb:BruAb1_1330 hypothetical sulfate ABC transporter, sulfate-binding protein, ev=1e-114, 63% identity YP_611568.1 KEGG: bja:blr7618 hypothetical protein, ev=1e-62, 36% identity YP_611569.1 PFAM: response regulator receiver: (3.4e-42) transcriptional regulatory protein-like: (1.6e-18); KEGG: bja:blr7619 two-component response regulator, ev=6e-70, 56% identity YP_611570.1 PFAM: ATP-binding region, ATPase-like: (1.9e-24) histidine kinase, HAMP region: (6.2e-08) histidine kinase A-like: (2.8e-15); KEGG: bja:blr7620 two-component hybrid sensor and regulator, ev=1e-95, 40% identity YP_611571.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase: (2.6e-90); KEGG: cvi:CV2245 flavoprotein NADH-dependent oxidoreductase, ev=1e-133, 65% identity YP_611572.1 PFAM: regulatory protein, LysR: (1.2e-16) LysR, substrate-binding: (1.4e-47); KEGG: bur:Bcep18194_B2913 transcriptional regulator, LysR family, ev=2e-97, 62% identity YP_611573.1 PFAM: regulatory protein, LysR: (1.8e-20) LysR, substrate-binding: (5.2e-43); KEGG: pfl:PFL_2646 transcriptional regulator, LysR family, ev=2e-87, 56% identity YP_611574.1 KEGG: bur:Bcep18194_C7720 hypothetical protein, ev=2e-86, 56% identity YP_611575.1 PFAM: ABC transporter related: (5.8e-43); SMART: ATPase: (5.3e-13); KEGG: jan:Jann_1427 ABC transporter related, ev=1e-110, 77% identity YP_611576.1 PFAM: inner-membrane translocator: (1.9e-72); KEGG: jan:Jann_1426 inner-membrane translocator, ev=1e-157, 74% identity YP_611577.1 PFAM: periplasmic binding protein/LacI transcriptional regulator: (0.0044); KEGG: jan:Jann_1425 periplasmic binding protein/LacI transcriptional regulator, ev=1e-139, 76% identity YP_611578.1 PFAM: regulatory protein, LacI: (2.7e-05) periplasmic binding protein/LacI transcriptional regulator: (3.5e-06); KEGG: jan:Jann_1424 transcriptional regulator, LacI family, ev=1e-138, 71% identity YP_611579.1 PFAM: oxidoreductase-like: (6.4e-40) Oxidoreductase-like: (3.2e-10); KEGG: jan:Jann_1423 oxidoreductase-like, ev=1e-179, 80% identity YP_611580.1 PFAM: Xylose isomerase-like TIM barrel: (5.8e-32); KEGG: jan:Jann_1422 xylose isomerase-like, ev=1e-138, 78% identity YP_611581.1 PFAM: oxidoreductase-like: (1.3e-26) Oxidoreductase-like: (0.0011); KEGG: jan:Jann_1421 oxidoreductase-like, ev=1e-154, 71% identity YP_611582.1 PFAM: thiamine pyrophosphate enzyme-like TPP-binding: (4.4e-21) thiamine pyrophosphate enzyme, central region: (1.9e-29) thiamine pyrophosphate enzyme-like TPP binding region: (4.2e-06); KEGG: jan:Jann_1420 thiamine pyrophosphate enzyme protein, ev=0.0, 75% identity YP_611583.1 PFAM: PfkB: (1e-55); KEGG: jan:Jann_1419 PfkB, ev=1e-112, 62% identity YP_611584.1 KEGG: jan:Jann_1418 myo-inositol catabolism IolB protein, ev=1e-128, 76% identity YP_611585.1 PFAM: ketose-bisphosphate aldolase, class-II: (6.2e-38); KEGG: jan:Jann_1417 fructose-bisphosphate aldolase, ev=1e-115, 73% identity YP_611586.1 PFAM: oxidoreductase-like: (4e-28) Oxidoreductase-like: (1.8e-09); KEGG: jan:Jann_1416 myo-inositol 2-dehydrogenase, ev=1e-120, 66% identity YP_611587.1 PFAM: conserved hypothetical protein 698: (8.6e-58); KEGG: rsp:RSP_4010 conserved hypothetical protein 698, ev=5e-94, 55% identity YP_611588.1 PFAM: Di-haem cytochrome c peroxidase: (1.8e-12); KEGG: jan:Jann_3672 di-haem cytochrome c peroxidase, ev=1e-94, 44% identity YP_611589.1 PFAM: Sel1-like repeat: (0.0001); KEGG: mca:MCA0405 hypothetical protein, ev=7e-15, 35% identity YP_611590.1 PFAM: Stress responsive alpha-beta barrel: (2.3e-12); KEGG: jan:Jann_3925 stress responsive alpha-beta, ev=1e-14, 45% identity YP_611591.1 PFAM: TRAP dicarboxylate transporter- DctP subunit: (2.7e-40); KEGG: chy:CHY_1301 TRAP dicarboxylate transporter, DctP subunit, ev=1e-41, 34% identity YP_611592.1 TIGRFAM: TRAP dicarboxylate transporter- DctM subunit: (2.6e-125); PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (2e-132); KEGG: sme:SMb20444 hypothetical protein, ev=5e-86, 38% identity YP_611593.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component: (8.7e-09); KEGG: bha:BH2672 C4-dicarboxylate transport system (permease small protein), ev=2e-08, 26% identity YP_611594.1 PFAM: flavin reductase-like, FMN-binding: (2.9e-38); KEGG: rsp:RSP_2607 nitrilotriacetate monooxygenase component B, ev=7e-43, 56% identity YP_611595.1 PFAM: aldo/keto reductase: (1.3e-38); KEGG: jan:Jann_1942 aldo/keto reductase, ev=1e-107, 65% identity YP_611596.1 PFAM: luciferase-like: (1.2e-05); KEGG: jan:Jann_1941 alkanesulfonate monooxygenase, ev=0.0, 83% identity YP_611597.1 PFAM: regulatory protein GntR, HTH: (6.1e-19) UbiC transcription regulator-associated: (3.3e-15); KEGG: atc:AGR_L_3074 transcription regulator, GntR family, ev=2e-64, 55% identity YP_611598.1 PFAM: oxidoreductase-like: (1.4e-19) Oxidoreductase-like: (1.1e-06); KEGG: jan:Jann_1939 oxidoreductase-like, ev=1e-126, 62% identity YP_611599.1 PFAM: protein of unknown function DUF125, transmembrane: (1.7e-76); KEGG: mlo:mlr6622 similar to nodulin 21, ev=1e-64, 58% identity YP_611600.1 PFAM: LytTr DNA-binding region: (4.1e-15); KEGG: rsp:RSP_0660 hypothetical protein, ev=4e-11, 32% identity YP_611601.1 PFAM: MltA-interacting MipA: (9.4e-33); KEGG: atc:AGR_C_1796 outer membrane protein, ev=9e-17, 27% identity YP_611602.1 KEGG: bmb:BruAb2_1095 fumarylacetoacetate hydrolase family protein, ev=3e-07, 28% identity YP_611603.1 PFAM: ABC-1: (1.9e-36); KEGG: rsp:RSP_3305 ubiquinol-cytochrome-c reductase assembly protein, ev=1e-128, 55% identity YP_611604.1 KEGG: jan:Jann_2809 DNA photolyase-like protein, ev=1e-89, 47% identity YP_611605.1 PFAM: ATP-binding region, ATPase-like: (4.2e-33) histidine kinase A-like: (2.9e-15); KEGG: eba:ebA6722 histidine kinase, ev=3e-60, 46% identity YP_611606.1 PFAM: response regulator receiver: (0.00047); KEGG: eba:ebA6722 histidine kinase, ev=1e-11, 37% identity YP_611607.1 PFAM: response regulator receiver: (4.3e-40) transcriptional regulatory protein-like: (1.6e-16); KEGG: bja:bll1029 two-component response regulator, ev=2e-53, 47% identity YP_611608.1 PFAM: Hemolysin-type calcium-binding region: (0.014); KEGG: bja:bll7673 hypothetical protein, ev=5e-68, 40% identity YP_611609.1 TIGRFAM: sarcosine oxidase, beta subunit family: (1.9e-287); PFAM: FAD dependent oxidoreductase: (1.6e-85); KEGG: sil:SPO1588 sarcosine oxidase, beta subunit family, ev=0.0, 82% identity YP_611610.1 PFAM: Sarcosine oxidase, delta subunit, heterotetrameric: (4.2e-22); KEGG: sil:SPO1587 sarcosine oxidase, delta subunit family, ev=9e-34, 73% identity YP_611611.1 TIGRFAM: sarcosine oxidase, alpha subunit family: (0); PFAM: glycine cleavage T protein (aminomethyl transferase): (1.8e-53); KEGG: sil:SPO1586 sarcosine oxidase, alpha subunit family, ev=0.0, 73% identity YP_611612.1 KEGG: sil:SPO1585 sarcosine oxidase, gamma subunit family, ev=2e-35, 42% identity YP_611613.1 PFAM: helix-turn-helix, AraC type: (4.5e-06) ThiJ/PfpI: (0.00013); KEGG: sil:SPO1584 transcriptional regulator, AraC family, ev=2e-89, 51% identity YP_611614.1 PFAM: regulatory protein, LysR: (2.6e-17) LysR, substrate-binding: (6e-45); KEGG: sil:SPO3192 transcriptional regulator, LysR family, ev=2e-47, 41% identity YP_611615.1 PFAM: aldehyde dehydrogenase: (2.1e-186); KEGG: sil:SPO3191 aldehyde dehydrogenase family protein, ev=0.0, 89% identity YP_611616.1 PFAM: peptidase M19, renal dipeptidase: (7.8e-102); KEGG: sil:SPO3190 renal dipeptidase family protein, ev=1e-168, 85% identity YP_611617.1 PFAM: BCCT transporter: (1.4e-60); KEGG: pha:PSHAa1072 glycine betaine transporter, ev=0.0, 61% identity YP_611618.1 KEGG: sil:SPO3189 hypothetical protein, ev=0.0, 66% identity YP_611619.1 KEGG: sil:SPO3188 hypothetical protein, ev=2e-39, 46% identity YP_611620.1 PFAM: Malate/L-lactate dehydrogenase: (2.7e-29); KEGG: sil:SPO3187 malate/L-lactate dehydrogenase family protein, ev=1e-140, 73% identity YP_611621.1 PFAM: aminoglycoside phosphotransferase: (2.5e-18) peptidase M23B: (1.9e-11) aminotransferase class-III: (1.8e-49); KEGG: sil:SPO0791 M23/M37 peptidase/aminotransferase, class III, ev=0.0, 74% identity YP_611622.1 PFAM: regulatory protein, LysR: (8e-21) LysR, substrate-binding: (7.8e-29); KEGG: bpm:BURPS1710b_0203 transcriptional regulator, LysR family, ev=6e-70, 48% identity YP_611623.1 PFAM: glucose-methanol-choline oxidoreductase: (2.2e-80) GMC oxidoreductase: (4e-48); KEGG: reu:Reut_A3372 glucose-methanol-choline oxidoreductase:FAD dependent oxidoreductase:GMC oxidoreductase, ev=0.0, 62% identity YP_611624.1 PFAM: aldo/keto reductase: (9.9e-11); KEGG: atc:AGR_L_2607 D-threo-aldose 1-dehydrogenase, ev=3e-84, 53% identity YP_611625.1 PFAM: Mandelate racemase/muconate lactonizing enzyme-like: (7e-08); KEGG: bur:Bcep18194_B0622 mandelate racemase/muconate lactonizing enzyme, ev=0.0, 74% identity YP_611626.1 PFAM: fumarylacetoacetate (FAA) hydrolase: (6.1e-83); KEGG: jan:Jann_2105 5-carboxymethyl-2-hydroxymuconate delta-isomerase, ev=1e-122, 73% identity YP_611627.1 PFAM: short-chain dehydrogenase/reductase SDR: (1.1e-25); KEGG: atc:AGR_L_807 oxidoreductase UcpA, ev=1e-89, 70% identity YP_611628.1 PFAM: protein of unknown function DUF718: (1e-64); KEGG: atc:AGR_C_5099 hypothetical protein Cj0488, ev=6e-48, 77% identity YP_611629.1 PFAM: Mandelate racemase/muconate lactonizing enzyme-like: (6.2e-15); KEGG: mlo:mll7149 mandelate racemase, ev=1e-144, 68% identity YP_611630.1 PFAM: ABC transporter related: (1.2e-64) TOBE: (3.8e-05) Transport-associated OB: (0.0017); SMART: ATPase: (2.4e-18); KEGG: bmb:BruAb1_0233 sugar ABC transporter, ATP-binding protein, ev=1e-132, 65% identity YP_611631.1 PFAM: binding-protein-dependent transport systems inner membrane component: (4.3e-23); KEGG: sme:SMb21105 sugar uptake ABC transporter permease protein, ev=1e-128, 76% identity YP_611632.1 PFAM: binding-protein-dependent transport systems inner membrane component: (0.00039); KEGG: bms:BR0236 sugar ABC transporter, permease protein, ev=1e-127, 73% identity YP_611633.1 PFAM: extracellular solute-binding protein, family 1: (4.1e-18); KEGG: bmb:BruAb1_0230 sugar ABC transporter, periplasmic sugar-binding protein, ev=1e-161, 64% identity YP_611634.1 PFAM: regulatory proteins, IclR: (9.9e-05); KEGG: bur:Bcep18194_B0136 transcriptional regulator, IclR family, ev=4e-58, 45% identity YP_611635.1 PFAM: amidohydrolase 2: (5.2e-29); KEGG: amidohydrolase family superfamily, ev=4e-63, 50% identity YP_611636.1 PFAM: chromosome segregation and condensation protein ScpB: (1.6e-46); KEGG: mlo:mlr9362 hypothetical protein, ev=1e-52, 55% identity YP_611637.1 PFAM: protein of unknown function DUF1403: (9.8e-77); KEGG: mlo:mlr6196 hypothetical protein, ev=7e-27, 34% identity YP_611638.1 KEGG: mlo:mll9356 integrase, ev=3e-53, 40% identity YP_611639.1 PFAM: ParB-like nuclease: (2.9e-15); KEGG: rsp:RSP_1422 ParB-like nuclease, ev=1e-74, 46% identity YP_611640.1 PFAM: Cobyrinic acid a,c-diamide synthase: (8e-21); KEGG: rsp:RSP_1423 ParA family ATPase, ev=0.0, 81% identity YP_611641.1 PFAM: initiator RepB protein: (0.0063); KEGG: rsp:RSP_1425 plasmid replication initiation protein, ev=1e-153, 64% identity YP_611642.1 catalyzes the formation of malonyl-CoA from malonate and CoA YP_611643.1 PFAM: helix-turn-helix, AraC type: (5.8e-08); KEGG: sil:SPO1057 transcriptional regulator, AraC family, ev=4e-65, 40% identity YP_611644.1 PFAM: NmrA-like: (0.00044); KEGG: sil:SPO1056 hypothetical protein, ev=2e-95, 60% identity YP_611645.1 KEGG: sil:SPO1055 membrane protein, , ev=8e-35, 56% identity YP_611646.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_611647.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. YP_611648.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm YP_611649.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_611650.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_611651.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_611652.1 PFAM: ApbE-like lipoprotein: (4.8e-87); KEGG: sil:SPOA0036 thiamin biosynthesis lipoprotein ApbE, ev=5e-79, 48% identity YP_611653.1 KEGG: sil:SPOA0037 hypothetical protein, ev=1e-24, 68% identity YP_611654.1 TIGRFAM: Hydrophobe/amphiphile efflux-1 HAE1: (0); PFAM: acriflavin resistance protein: (0); KEGG: bms:BRA0334 hydrophobe/amphiphile efflux-1 family protein, ev=0.0, 51% identity YP_611655.1 PFAM: secretion protein HlyD: (2.1e-22); KEGG: bms:BRA0335 HlyD family secretion protein, ev=3e-62, 39% identity YP_611656.1 PFAM: WxcM-like: (3.7e-74); KEGG: tel:tlr1343 hypothetical protein, ev=1e-52, 73% identity YP_611657.1 PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes: (0.0026) DegT/DnrJ/EryC1/StrS aminotransferase: (9.3e-158) aromatic amino acid beta-eliminating lyase/threonine aldolase: (0.0029); KEGG: tel:tlr1344 probable aminotransferase, ev=1e-123, 59% identity YP_611658.1 PFAM: glycosyl transferase, family 2: (1.3e-21); KEGG: mca:MCA1508 glycosyl transferase, group 2 family, ev=5e-21, 27% identity YP_611659.1 KEGG: xac:XAC1690 hypothetical protein, ev=7e-69, 44% identity YP_611660.1 KEGG: xac:XAC1689 hypothetical protein, ev=1e-58, 41% identity YP_611661.1 KEGG: xac:XAC1688 hypothetical protein, ev=4e-48, 46% identity YP_611662.1 PFAM: Tetratricopeptide TPR_2: (0.00021); KEGG: ccr:CC3718 TPR domain protein, ev=2e-85, 38% identity YP_611663.1 PFAM: Rhodanese-like: (2.5e-13); KEGG: sil:SPO0091 rhodanese-like domain protein, ev=1e-153, 86% identity YP_611664.1 PFAM: isochorismatase hydrolase: (2.3e-14); KEGG: sil:SPO0093 pyrazinamidase/nicotinamidase, ev=2e-82, 74% identity YP_611665.1 PFAM: response regulator receiver: (1.9e-30) ATP-binding region, ATPase-like: (1.9e-42) histidine kinase A-like: (1.1e-23) PAS fold-3: (4.6e-10) PAS fold-4: (8.8e-10) PAS fold: (3.1e-13); SMART: PAS: (3.6e-10) PAC motif: (1.9e-08); KEGG: sil:SPO0094 sensory box sensor histidine kinase/response regulator, ev=1e-156, 44% identity YP_611666.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_611668.1 PFAM: ABC transporter related: (4.5e-61) Oligopeptide/dipeptide ABC transporter-like: (9.6e-05); SMART: ATPase: (8.4e-19); KEGG: sil:SPO0098 peptide/opine/nickel uptake family ABC transporter, ATP-binding protein, ev=0.0, 69% identity YP_611669.1 PFAM: binding-protein-dependent transport systems inner membrane component: (2.7e-42); KEGG: sil:SPO0099 peptide/opine/nickel uptake family ABC transporter, permease protein, ev=1e-121, 80% identity YP_611670.1 PFAM: binding-protein-dependent transport systems inner membrane component: (2.7e-45); KEGG: sil:SPO0100 peptide/opine/nickel uptake family ABC transporter, permease protein, ev=1e-147, 84% identity YP_611671.1 PFAM: extracellular solute-binding protein, family 5: (2.4e-87); KEGG: sil:SPO0101 peptide/opine/nickel uptake family ABC transporter, periplasmic substrate-binding protein, ev=0.0, 77% identity YP_611672.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_611673.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_611674.1 TIGRFAM: glycerol kinase: (6.1e-293); PFAM: carbohydrate kinase, FGGY: (2e-102); KEGG: sil:SPO0104 glycerol kinase, ev=0.0, 75% identity YP_611675.1 PFAM: monooxygenase, FAD-binding: (4e-06); KEGG: sil:SPO0105 monooxygenase family protein, ev=0.0, 73% identity YP_611676.1 KEGG: sil:SPO0131 isopentyl-diphosphate delta-isomerase, ev=1e-75, 71% identity; TIGRFAM: Isopentenyl-diphosphate delta-isomerase, type 1: (4.2e-35); PFAM: NUDIX hydrolase: (8.5e-26) YP_611677.1 PFAM: cytochrome c, class I: (7.9e-27); KEGG: sil:SPO0130 cytochrome c family protein, ev=1e-41, 62% identity YP_611680.1 PFAM: protein of unknown function DUF188: (2e-34); KEGG: sil:SPO3827 YaiI/YqxD family protein, ev=3e-65, 83% identity YP_611681.1 catalyzes the conversion of NADPH to NADH YP_611682.1 PFAM: esterase: (1.2e-74); KEGG: sil:SPO3829 S-formylglutathione hydrolase, , ev=1e-133, 80% identity YP_611683.1 PFAM: protein of unknown function DUF861, cupin_3: (2.1e-32); KEGG: sil:SPO3326 hypothetical protein, ev=7e-45, 75% identity YP_611684.1 PFAM: Auxin Efflux Carrier: (2.3e-15); KEGG: sil:SPO3843 malonate transporter, , ev=1e-126, 73% identity YP_611685.1 PFAM: regulatory protein, TetR: (7.5e-18); KEGG: rsp:RSP_6137 transcriptional regulator, TetR family, ev=2e-58, 58% identity YP_611686.1 PFAM: regulatory protein, ArsR: (0.0022); KEGG: sil:SPO3809 transcriptional regulator, ArsR family, ev=3e-67, 58% identity YP_611687.1 KEGG: jan:Jann_0104 hypothetical protein, ev=6e-41, 79% identity YP_611688.1 PFAM: NLP/P60: (2.4e-06); KEGG: sil:SPO3718 NLP/P60 family protein, ev=3e-82, 59% identity YP_611689.1 PFAM: peptidase M17, leucyl aminopeptidase-like: (4e-101); KEGG: sil:SPO3717 cytosol aminopeptidase family protein, ev=1e-167, 67% identity YP_611690.1 KEGG: sil:SPO3716 hypothetical protein, ev=4e-39, 65% identity YP_611691.1 PFAM: carbonic anhydrase: (3.6e-32); KEGG: sil:SPO3715 carbonic anhydrase, , ev=1e-102, 80% identity YP_611692.1 KEGG: sil:SPO3710 hypothetical protein, ev=1e-112, 52% identity YP_611693.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_611694.1 TIGRFAM: conserved hypothetical protein: (5.3e-26); KEGG: sil:SPO3713 hypothetical protein, ev=2e-98, 39% identity YP_611696.1 PFAM: amidohydrolase: (0.0044) Amidohydrolase 3: (1e-100); KEGG: pfl:PFL_2413 conserved hypothetical protein, ev=1e-160, 51% identity YP_611697.1 PFAM: HpcH/HpaI aldolase: (1.3e-83); KEGG: sil:SPO3686 HpcH/HpaI aldolase family protein, ev=1e-106, 73% identity YP_611698.1 KEGG: sil:SPOA0024 2-oxo-hepta-3-ene-1,7-dioic acid hydratase, , ev=1e-105, 71% identity; TIGRFAM: 2-oxo-hepta-3-ene-1,7-dioic acid hydratase: (5.1e-149); PFAM: Hydratase/decarboxylase: (3e-90) YP_611699.1 PFAM: fumarylacetoacetate (FAA) hydrolase: (1.5e-37); KEGG: sil:SPOA0025 fumarylacetoacetate hydrolase family protein, ev=1e-116, 71% identity YP_611700.1 PFAM: Pyridoxal-dependent decarboxylase: (7.4e-117); KEGG: sil:SPO3687 decarboxylase, pyridoxal-dependent, ev=0.0, 82% identity YP_611701.1 KEGG: sil:SPO3688 extradiol ring-cleavage dioxygenase family protein, ev=1e-168, 84% identity; TIGRFAM: 3,4-dihydroxyphenylacetate 2,3-dioxygenase HpaD: (4.2e-168); PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (5.9e-22) YP_611702.1 KEGG: sil:SPOA0027 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase, ev=0.0, 78% identity; TIGRFAM: 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase: (0); PFAM: aldehyde dehydrogenase: (1.2e-243) YP_611703.1 PFAM: 5-carboxymethyl-2-hydroxymuconate isomerase: (1.4e-11); KEGG: sil:SPOA0320 5-carboxymethyl-2-hydroxymuconate delta isomerase, ev=1e-34, 56% identity YP_611704.1 TIGRFAM: Homoprotocatechuate degradation transcriptional regulator HpaR: (2.2e-37); PFAM: regulatory protein, MarR: (1.7e-20); KEGG: sil:SPO3689 transcriptional regulator, MarR family, ev=3e-38, 60% identity YP_611705.1 PFAM: MOFRL: (1.3e-46); KEGG: sil:SPO1564 MOFRL domain protein, ev=3e-96, 49% identity YP_611706.1 PFAM: protein of unknown function DUF861, cupin_3: (7.2e-18) Cupin 2, conserved barrel: (2.9e-06); KEGG: bur:Bcep18194_B0211 protein of unknown function DUF861, ev=1e-126, 76% identity YP_611707.1 TIGRFAM: uracil-xanthine permease: (6.1e-108); PFAM: Xanthine/uracil/vitamin C permease: (6.3e-97); KEGG: sil:SPO0874 xanthine/uracil permease family protein, ev=0.0, 85% identity YP_611708.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_611709.1 PFAM: polysaccharide deacetylase: (2.9e-06); KEGG: rsp:RSP_1554 possible polysaccharide deacetylase, ev=0.0, 74% identity YP_611710.1 PFAM: Transthyretin: (3.6e-59); KEGG: jan:Jann_2609 transthyretin, ev=6e-46, 69% identity YP_611711.1 PFAM: regulatory protein, LysR: (4.6e-19) LysR, substrate-binding: (2.4e-43); KEGG: sil:SPO0870 transcriptional regulator, LysR family, ev=1e-114, 67% identity YP_611712.1 PFAM: protein of unknown function DUF989: (2e-260); KEGG: sil:SPO0869 membrane protein, , ev=1e-179, 74% identity YP_611713.1 Catalyzes the deamination of guanine YP_611714.1 PFAM: response regulator receiver: (0.00015); KEGG: lic:LIC12088 response regulator, ev=1e-10, 44% identity YP_611715.1 PFAM: ABC transporter related: (3.1e-55) Transport-associated OB: (4e-10); SMART: ATPase: (5.9e-14); KEGG: jan:Jann_3840 ABC transporter related, ev=1e-137, 69% identity YP_611716.1 PFAM: regulatory proteins, IclR: (1.8e-32); KEGG: jan:Jann_3839 transcriptional regulator, IclR family, ev=8e-86, 64% identity YP_611717.1 PFAM: extracellular solute-binding protein, family 1: (1.4e-30); KEGG: jan:Jann_3838 extracellular solute-binding protein, family 1, ev=1e-164, 67% identity YP_611718.1 PFAM: binding-protein-dependent transport systems inner membrane component: (5.4e-05); KEGG: jan:Jann_3837 binding-protein-dependent transport systems inner membrane component, ev=1e-106, 59% identity YP_611719.1 PFAM: binding-protein-dependent transport systems inner membrane component: (6e-18); KEGG: jan:Jann_3836 binding-protein-dependent transport systems inner membrane component, ev=1e-126, 78% identity YP_611720.1 PFAM: glycoside hydrolase, clan GH-D: (1.6e-139); KEGG: jan:Jann_3835 glycoside hydrolase, clan GH-D, ev=0.0, 60% identity YP_611721.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate YP_611722.1 PFAM: short-chain dehydrogenase/reductase SDR: (8.3e-27); KEGG: jan:Jann_3834 short-chain dehydrogenase/reductase SDR, ev=1e-106, 74% identity YP_611723.1 PFAM: 2-keto-3-deoxy-galactonokinase: (5.5e-49); KEGG: rsp:RSP_1371 2-dehydro-3-deoxygalactonokinase, ev=1e-77, 49% identity YP_611724.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism YP_611725.1 PFAM: Senescence marker protein-30 (SMP-30)-like: (3.9e-22) SMP-30/Gluconolaconase/LRE-like region: (7.8e-35); KEGG: jan:Jann_3831 senescence marker protein-30 (SMP-30), ev=2e-84, 55% identity YP_611726.1 PFAM: Glycoside hydrolase, family 42-like: (3.3e-221) Beta-galactosidase trimerisation: (4.6e-51) Beta-galactosidase-like: (4.8e-05); KEGG: jan:Jann_3830 beta-galactosidase, ev=0.0, 62% identity YP_611727.1 PFAM: metallophosphoesterase: (1.1e-15); KEGG: sme:SMc01909 hypothetical protein, ev=5e-91, 43% identity YP_611728.1 KEGG: rsp:RSP_3215 hypothetical protein, ev=1e-127, 32% identity YP_611729.1 TIGRFAM: diaminopimelate decarboxylase: (1.1e-183); PFAM: Orn/DAP/Arg decarboxylase 2: (3.4e-38); KEGG: sil:SPO0334 diaminopimelate decarboxylase, ev=0.0, 88% identity YP_611730.1 TIGRFAM: conserved hypothetical protein: (1.7e-77); KEGG: sil:SPO0335 hypothetical protein, ev=0.0, 58% identity YP_611731.1 TIGRFAM: Zinc finger/thioredoxin : (8.4e-12); KEGG: sil:SPO0336 MJ0042 family finger-like domain protein, ev=2e-57, 43% identity YP_611732.1 PFAM: ABC transporter related: (8.5e-41); SMART: ATPase: (3e-15); KEGG: sil:SPO0337 cell division ATP-binding protein FtsE, ev=3e-99, 79% identity YP_611733.1 PFAM: protein of unknown function DUF214: (0.0015); KEGG: sil:SPO0338 cell division permease protein FtsX, , ev=1e-122, 78% identity YP_611734.1 PFAM: phospholipid/glycerol acyltransferase: (2.6e-15); KEGG: sil:SPO0339 acyltransferase family protein, ev=1e-97, 70% identity YP_611735.1 PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding: (4.1e-14); KEGG: jan:Jann_3730 pyridoxamine 5'-phosphate oxidase-related, FMN-binding, ev=5e-61, 59% identity YP_611737.1 PFAM: Ethyl tert-butyl ether degradation EthD: (2.9e-06); KEGG: sil:SPO0315 hypothetical protein, ev=7e-26, 51% identity YP_611738.1 TIGRFAM: Dihydrolipoamide dehydrogenase: (4.2e-233); PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (2.4e-32) glucose-inhibited division protein A: (0.003) fumarate reductase/succinate dehydrogenase flavoprotein-like: (0.0029) pyridine nucleotide-disulphide oxidoreductase dimerisation region: (2.1e-55); KEGG: sil:SPO0340 2-oxoglutarate dehydrogenase, E3 component, dihydrolipoamide dehydrogenase, ev=0.0, 78% identity YP_611739.1 KEGG: mlo:mlr7497 hypothetical protein, ev=3e-45, 60% identity YP_611740.1 KEGG: jan:Jann_0835 inner membrane protein, ev=3e-49, 69% identity YP_611741.1 KEGG: jan:Jann_0835 inner membrane protein, ev=1e-26, 44% identity YP_611744.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_611745.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_611746.1 TIGRFAM: succinyl-CoA synthetase, alpha subunit: (1.7e-145); PFAM: CoA-binding: (3e-51) ATP-citrate lyase/succinyl-CoA ligase: (5.9e-51); KEGG: jan:Jann_0827 succinyl-CoA synthetase, alpha subunit, ev=1e-151, 89% identity YP_611747.1 PFAM: glycosyl transferase, family 25: (2.9e-15); KEGG: jan:Jann_0824 glycosyl transferase, family 25, ev=2e-43, 38% identity YP_611748.1 catalyzes the interconversion of succinyl-CoA and succinate YP_611751.1 Catalyzes the reversible oxidation of malate to oxaloacetate YP_611753.1 KEGG: sil:SPO0351 hypothetical protein, ev=5e-29, 61% identity YP_611754.1 PFAM: HpcH/HpaI aldolase: (1.9e-43); KEGG: sil:SPO0352 citrate lyase, beta subunit, ev=1e-127, 80% identity YP_611755.1 PFAM: NnrU: (1.5e-16); KEGG: sil:SPO0353 NnrU family protein, ev=2e-69, 67% identity YP_611756.1 KEGG: rsp:RSP_0972 hypothetical protein, ev=1e-24, 71% identity YP_611757.1 KEGG: sil:SPO0355 hypothetical protein, ev=1e-165, 82% identity YP_611758.1 PFAM: Phosphoglycerate mutase: (2.1e-05); KEGG: jan:Jann_3544 phosphoglycerate mutase, ev=5e-45, 54% identity YP_611759.1 PFAM: succinate dehydrogenase, cytochrome b subunit: (5.3e-41); KEGG: jan:Jann_0811 succinate dehydrogenase, cytochrome b subunit, ev=5e-39, 60% identity YP_611760.1 KEGG: sil:SPO0359 succinate dehydrogenase, hydrophobic membrane anchor protein, ev=8e-32, 53% identity YP_611761.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_611764.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_611765.1 PFAM: Phytanoyl-CoA dioxygenase: (2.4e-27); KEGG: ret:RHE_CH03702 hypothetical protein, ev=1e-118, 58% identity YP_611766.1 PFAM: regulatory protein, LacI: (0.00039); KEGG: sco:SCO6986 DNA-binding protein, ev=9e-71, 44% identity YP_611767.1 PFAM: phage integrase: (0.001) YP_611768.1 PFAM: transposase IS3/IS911: (2.9e-19); KEGG: ret:RHE_PA00090 probable insertion sequence transposase protein, IS3/IS911 family, ev=2e-34, 77% identity YP_611769.1 PFAM: Integrase, catalytic region: (4.6e-37); KEGG: mlo:mll6088 transposase, ev=1e-117, 75% identity YP_611770.1 PFAM: helicase-like: (0.0023) type III restriction enzyme, res subunit: (3.3e-47) protein of unknown function DUF450: (4.7e-19) DEAD/DEAH box helicase-like: (2.4e-05); KEGG: mac:MA2418 type I site-specific deoxyribonuclease protein R, ev=0.0, 53% identity YP_611771.1 PFAM: protein of unknown function DUF262: (5.4e-07) protein of unknown function DUF1524 RloF: (3.3e-42); KEGG: mac:MA2417 hypothetical protein, ev=0.0, 61% identity YP_611772.1 KEGG: mac:MA2416 hypothetical protein, ev=5e-53, 36% identity YP_611773.1 PFAM: restriction modification system DNA specificity domain: (1.2e-30); KEGG: rba:RB11412 probable type I restriction enzyme EcoBI specificity protein, ev=1e-60, 50% identity YP_611774.1 PFAM: N-6 DNA methylase: (5e-32); KEGG: rba:RB11642 type I restriction enzym, M protein, ev=0.0, 64% identity YP_611775.1 PFAM: phage integrase: (0.001); KEGG: aci:ACIAD2657 site-specific tyrosine recombinase, ev=2e-06, 23% identity YP_611777.1 PFAM: BRO-like: (0.002); KEGG: bme:BMEI0899 phage-related DNA binding protein, ev=6e-10, 32% identity YP_611779.1 PFAM: protein of unknown function DUF45: (4.2e-63); KEGG: dvu:DVU1702 hypothetical protein, ev=4e-63, 49% identity YP_611780.1 KEGG: dvu:DVU1703 type I restriction-modification enzyme, R subunit, ev=0.0, 59% identity; TIGRFAM: type I site-specific deoxyribonuclease, HsdR family: (3.6e-110); PFAM: type III restriction enzyme, res subunit: (2.7e-13) protein of unknown function DUF450: (1.8e-39); SMART: DEAD/DEAH box helicase-like: (2.5e-08) YP_611781.1 PFAM: restriction modification system DNA specificity domain: (5.3e-17); KEGG: dvu:DVU1705 type I restriction-modification enzyme, S subunit, ev=1e-34, 36% identity YP_611782.1 TIGRFAM: type I restriction-modification system, M subunit: (6.6e-75); PFAM: N-6 DNA methylase: (1.5e-137); KEGG: dvu:DVU1709 type I restriction-modification system, M subunit, ev=0.0, 72% identity YP_611783.1 PFAM: BRO-like: (0.002); KEGG: bme:BMEI0899 phage-related DNA binding protein, ev=6e-10, 32% identity YP_611784.1 PFAM: phage integrase: (0.00022); KEGG: dar:Daro_0788 phage integrase, ev=2e-42, 31% identity YP_611785.1 PFAM: protein of unknown function DUF329: (8.3e-13); KEGG: jan:Jann_2867 protein of unknown function DUF329, ev=5e-15, 66% identity YP_611786.1 KEGG: sil:SPOA0079 ribonuclease, Rne/Rng family, ev=1e-137, 73% identity YP_611787.1 TIGRFAM: maf protein: (1.4e-48); PFAM: Maf-like protein: (3.4e-62); KEGG: rsp:RSP_0625 Maf-like protein, ev=1e-79, 76% identity YP_611788.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_611789.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase: (1.6e-07); KEGG: sil:SPOA0076 hydrolase, carbon-nitrogen family, ev=1e-120, 71% identity YP_611790.1 KEGG: sil:SPOA0075 hypothetical protein, ev=8e-80, 72% identity YP_611791.1 TIGRFAM: conserved hypothetical protein: (8.1e-41); KEGG: sil:SPOA0074 hypothetical protein, ev=4e-52, 73% identity YP_611792.1 PFAM: low molecular weight phosphotyrosine protein phosphatase: (3.3e-12); KEGG: sil:SPOA0073 arsenate reductase, ev=2e-71, 84% identity YP_611793.1 PFAM: Uncharacterised conserved protein UCP032146: (8.4e-77); KEGG: sil:SPOA0072 hypothetical protein, ev=2e-76, 86% identity YP_611794.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_611795.1 KEGG: sil:SPOA0136 hypothetical protein, ev=5e-08, 71% identity YP_611796.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_611797.1 KEGG: sil:SPOA0138 hypothetical protein, ev=6e-62, 74% identity YP_611798.1 TIGRFAM: 3-oxoadipate enol-lactonase: (9.2e-103); PFAM: alpha/beta hydrolase fold: (5.3e-13); KEGG: sil:SPOA0434 3-oxoadipate enol-lactone hydrolase, ev=8e-85, 58% identity YP_611799.1 PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit: (1e-64); KEGG: rsp:RSP_2252 threonine dehydratase, ev=1e-135, 76% identity YP_611800.1 PFAM: alpha/beta hydrolase fold: (3.6e-13); KEGG: sil:SPOA0436 hydrolase, alpha/beta fold family, ev=4e-70, 50% identity YP_611801.1 TIGRFAM: haloacid dehalogenase, type II: (1.8e-73) HAD-superfamily hydrolase, subfamily IA, variant 2: (2e-24); PFAM: Haloacid dehalogenase-like hydrolase: (3.8e-26); KEGG: sil:SPOA0437 haloacid dehalogenase, type II, ev=5e-93, 73% identity YP_611802.1 PFAM: peptidylprolyl isomerase, FKBP-type: (1.6e-27); KEGG: sil:SPOA0438 peptidyl-prolyl cis-trans isomerase, FKBP-type, ev=8e-56, 70% identity YP_611803.1 KEGG: pca:Pcar_0492 spermidine/putrescine-binding periplasmic protein-like, ev=3e-16, 23% identity YP_611804.1 TIGRFAM: Lytic murein transglycosylase: (7.8e-111); PFAM: Peptidoglycan-binding domain 1: (1.6e-10); KEGG: sil:SPO3617 peptidoglycan-binding protein, , ev=1e-128, 60% identity YP_611805.1 KEGG: jan:Jann_1588 hypothetical protein, ev=3e-16, 45% identity YP_611806.1 KEGG: sil:SPOA0095 hypothetical protein, ev=1e-140, 68% identity YP_611807.1 KEGG: sil:SPOA0094 hypothetical protein, ev=6e-62, 85% identity YP_611808.1 PFAM: FAD linked oxidase-like: (1e-10); KEGG: sil:SPOA0093 FAD binding domain protein, ev=0.0, 80% identity YP_611809.1 TIGRFAM: Reductive dehalogenase: (3.9e-44); PFAM: ferredoxin: (2e-09) oxidoreductase FAD/NAD(P)-binding: (0.00012) 4Fe-4S ferredoxin, iron-sulfur binding: (0.00044) Oxidoreductase FAD-binding region: (0.00041); KEGG: sil:SPO0589 oxidoreductase, NAD-binding/iron-sulfur cluster-binding protein, ev=0.0, 74% identity YP_611811.1 KEGG: sil:SPO1693 hypothetical protein, ev=1e-107, 42% identity YP_611814.1 KEGG: rso:RSc2607 hypothetical protein, ev=7e-09, 53% identity YP_611816.1 PFAM: phage integrase: (7e-22); KEGG: rso:RSc2622 probable integrase protein, ev=5e-76, 41% identity YP_611817.1 PFAM: phage integrase: (3.5e-13); KEGG: gox:GOX2485 phage related integrase, ev=2e-21, 41% identity YP_611818.1 PFAM: Sporulation related: (3e-15); KEGG: sil:SPO2738 lipoprotein, , ev=8e-99, 66% identity YP_611819.1 PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1: (3.5e-66) Penicillin-binding protein 5-like: (5e-16); KEGG: sil:SPO2739 D-alanyl-D-alanine carboxypeptidase, ev=1e-151, 70% identity YP_611820.1 PFAM: thymidylate kinase: (2.9e-57); KEGG: sil:SPO2740 thymidylate kinase, ev=1e-91, 81% identity YP_611821.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_611822.1 PFAM: TatD-related deoxyribonuclease: (4.1e-93); KEGG: sil:SPO2742 hydrolase, TatD family, ev=1e-127, 82% identity YP_611823.1 PFAM: beta-lactamase-like: (3.1e-05); KEGG: jan:Jann_1274 beta-lactamase-like, ev=1e-110, 70% identity YP_611824.1 PFAM: Auxin Efflux Carrier: (4.7e-24); KEGG: sil:SPO2744 malonate transporter, , ev=1e-118, 68% identity YP_611825.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen: (0.00043) Redoxin: (1.9e-35); KEGG: rsp:RSP_2781 peroxiredoxin/glutaredoxin family protein, ev=2e-80, 76% identity YP_611826.1 PFAM: peptidase M20: (5e-17); KEGG: bur:Bcep18194_A4728 peptidase M20, ev=1e-135, 54% identity YP_611827.1 PFAM: gamma-glutamyltranspeptidase: (1e-69); KEGG: rpa:RPA0776 possible gamma-glutamyltranspeptidase precursor, ev=1e-142, 51% identity YP_611828.1 KEGG: psb:Psyr_2263 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal, ev=1e-109, 61% identity; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein-like: (2.2e-24); PFAM: ABC transporter related: (9.5e-69) Oligopeptide/dipeptide ABC transporter-like: (5.9e-25); SMART: ATPase: (3.7e-23) YP_611829.1 KEGG: psb:Psyr_2264 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal, ev=1e-112, 64% identity; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein-like: (4.7e-23); PFAM: ABC transporter related: (1.7e-54) Oligopeptide/dipeptide ABC transporter-like: (2.9e-25); SMART: ATPase: (1.1e-15) YP_611830.1 PFAM: binding-protein-dependent transport systems inner membrane component: (8e-38); KEGG: pst:PSPTO2574 peptide ABC transporter, permease protein, ev=4e-96, 59% identity YP_611831.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.3e-54); KEGG: pst:PSPTO2575 peptide ABC transporter, permease protein, ev=1e-103, 62% identity YP_611832.1 PFAM: extracellular solute-binding protein, family 5: (2.8e-75); KEGG: pst:PSPTO2576 peptide ABC transporter, periplasmic peptide-binding protein, ev=1e-143, 49% identity YP_611833.1 PFAM: regulatory proteins, IclR: (9.3e-16); KEGG: rru:Rru_A1344 transcriptional regulator, IclR family, ev=3e-56, 45% identity YP_611834.1 PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes: (2e-05) aromatic amino acid beta-eliminating lyase/threonine aldolase: (0.00022) aminotransferase, class I and II: (1.3e-65); KEGG: sil:SPOA0066 aspartate aminotransferase, , ev=1e-137, 64% identity YP_611835.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase: (8.3e-37); KEGG: bbr:BB2925 capsular polysaccharide biosynthesis protein, ev=1e-161, 65% identity YP_611836.1 PFAM: Asparaginase/glutaminase: (6.5e-73); KEGG: eca:ECA2340 cytoplasmic asparaginase I, ev=3e-50, 38% identity YP_611837.1 TIGRFAM: amino acid carrier protein: (3e-156); PFAM: sodium:alanine symporter: (8.8e-150); KEGG: ppr:PBPRA1278 hypothetical amino acid carrier protein(sodium/alanine symporter), ev=0.0, 71% identity YP_611838.1 PFAM: sugar isomerase (SIS): (0.0046); KEGG: sil:SPO1591 SIS domain protein, ev=3e-33, 30% identity YP_611839.1 PFAM: 60 kDa inner membrane insertion protein: (8e-07) pyruvate phosphate dikinase, PEP/pyruvate-binding: (7.4e-10) PEP-utilising enzyme, mobile region: (9.4e-15); SMART: Rhodanese-like: (4e-05); KEGG: gvi:glr2690 similar to phosphoenolpyruvate synthase, ev=9e-28, 25% identity YP_611840.1 TIGRFAM: Phosphonate-binding periplasmic protein: (5.5e-11); KEGG: ppr:PBPRB1010 hypothetical protein, ev=1e-66, 54% identity YP_611841.1 PFAM: response regulator receiver: (1.8e-28) ATP-binding region, ATPase-like: (3.5e-38) histidine kinase A-like: (2.4e-27); KEGG: mlo:mll3725 hybrid sensory histidine kinase, ev=1e-118, 44% identity YP_611842.1 PFAM: ABC-3: (1.5e-75); KEGG: jan:Jann_0315 ABC-3, ev=2e-95, 70% identity YP_611843.1 PFAM: ABC transporter related: (2.4e-47); SMART: ATPase: (6e-18); KEGG: sil:SPO0985 zinc ABC transporter, ATP-binding protein, ev=2e-88, 65% identity YP_611844.1 KEGG: jan:Jann_0313 ferric uptake regulator, FUR family, ev=5e-57, 67% identity YP_611845.1 PFAM: periplasmic solute binding protein: (2.6e-29); KEGG: jan:Jann_0312 periplasmic solute binding protein, ev=1e-90, 46% identity YP_611846.1 PFAM: homocysteine S-methyltransferase: (1.5e-124); KEGG: rsp:RSP_3347 methionine synthase, 5-methyltetrahydrofolate--homocysteine methyltransferase, ev=1e-152, 77% identity YP_611847.1 KEGG: rsp:RSP_3346 5-methyltetrahydrofolate--homocysteine methyltransferase, ev=0.0, 80% identity; TIGRFAM: 5-methyltetrahydrofolate--homocysteine methyltransferase: (0); PFAM: dihydropteroate synthase, DHPS: (2.2e-71) Methionine synthase, B12-binding module, cap: (1.1e-47) Vitamin B12 dependent methionine synthase, activation region: (2.2e-57) cobalamin B12-binding: (3.1e-26) YP_611848.1 PFAM: thiol-disulphide oxidoreductase DCC: (9.6e-22); KEGG: ret:RHE_CH01012 hypothetical protein, ev=6e-23, 40% identity YP_611849.1 PFAM: Saccharopine dehydrogenase: (5.7e-09); KEGG: ret:RHE_CH01011 hypothetical protein, ev=7e-60, 34% identity YP_611850.1 PFAM: aldehyde dehydrogenase: (4.8e-221); KEGG: bha:BH0681 aldehyde dehydrogenase, ev=0.0, 76% identity YP_611851.1 PFAM: helix-turn-helix, Fis-type: (1.3e-14) GAF: (6e-13); KEGG: bmb:BruAb1_0196 transcriptional regulator, Fis family, ev=2e-72, 49% identity YP_611852.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_611853.1 KEGG: jan:Jann_0455 hypothetical protein, ev=1e-66, 81% identity YP_611854.1 KEGG: mlo:mll3172 hypothetical protein, ev=2e-46, 50% identity YP_611856.1 PFAM: MscS Mechanosensitive ion channel: (1.6e-60); KEGG: sil:SPO3496 mechanosensitive ion channel family protein, ev=1e-114, 75% identity YP_611857.1 TIGRFAM: alanine dehydrogenase: (2.7e-173); PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding: (0.00062) alanine dehydrogenase/PNT-like: (3.2e-83); KEGG: sil:SPO0222 alanine dehydrogenase, ev=1e-180, 84% identity YP_611858.1 PFAM: regulatory proteins, AsnC/Lrp: (3.5e-31); KEGG: sil:SPO0223 transcriptional regulator, AsnC family, ev=1e-68, 85% identity YP_611859.1 PFAM: protein of unknown function DUF344: (4.5e-164); KEGG: sil:SPO0224 polyphosphate kinase, , ev=1e-156, 85% identity YP_611860.1 TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase: (1.2e-40); PFAM: CDP-alcohol phosphatidyltransferase: (6.2e-33); KEGG: sil:SPO3635 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, ev=1e-104, 81% identity YP_611861.1 TIGRFAM: molybdopterin converting factor, subunit 1: (5.7e-33); PFAM: thiamineS: (2.2e-19); KEGG: rsp:RSP_1072 molybdopterin MPT converting factor, subunit 1 protein, ev=2e-33, 86% identity YP_611862.1 PFAM: molybdopterin biosynthesis MoaE: (5.7e-46); KEGG: sil:SPO3633 molybdopterin converting factor, subunit 2, ev=1e-53, 72% identity YP_611863.1 PFAM: regulatory protein, LysR: (1.2e-18) LysR, substrate-binding: (6.8e-33); KEGG: sil:SPO0241 transcriptional regulator, LysR family, ev=1e-76, 47% identity YP_611864.1 PFAM: extracellular solute-binding protein, family 1: (0.00012); KEGG: hch:HCH_01471 spermidine/putrescine-binding periplasmic protein, ev=1e-136, 66% identity YP_611865.1 PFAM: ABC transporter related: (1e-61) Transport-associated OB: (9.4e-08); SMART: ATPase: (6.5e-18); KEGG: hch:HCH_01472 ABC-type spermidine/putrescine transport system, ATPase components, ev=1e-115, 59% identity YP_611866.1 PFAM: binding-protein-dependent transport systems inner membrane component: (3.4e-14); KEGG: hch:HCH_01473 ABC-type spermidine/putrescine transport system, permease component I, ev=1e-114, 72% identity YP_611867.1 PFAM: binding-protein-dependent transport systems inner membrane component: (0.001); KEGG: hch:HCH_01474 ABC-type spermidine/putrescine transport system, permease component II, ev=6e-93, 60% identity YP_611868.1 PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (1.4e-52); KEGG: hch:HCH_00746 TRAP-type mannitol/chloroaromatic compound transport system, large permease component, ev=1e-115, 46% identity YP_611869.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component: (4.7e-17); KEGG: tcx:Tcr_2006 tripartite ATP-independent periplasmic transporter, DctQ component, ev=2e-27, 43% identity YP_611870.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.0068); PFAM: TRAP dicarboxylate transporter- DctP subunit: (3.1e-38); KEGG: tcx:Tcr_2011 TRAP dicarboxylate transporter-DctP subunit, ev=1e-74, 41% identity YP_611871.1 PFAM: regulatory protein GntR, HTH: (4e-12) UbiC transcription regulator-associated: (2.2e-18); KEGG: rsp:RSP_2932 histidine utilization repressor, GntR family, ev=2e-42, 42% identity YP_611872.1 PFAM: cyclic nucleotide-binding: (1.6e-13) regulatory protein, Crp: (1.9e-07); KEGG: sil:SPO1615 cyclic nucleotide-binding protein, ev=3e-56, 48% identity YP_611874.1 PFAM: protein of unknown function DUF395, YeeE/YedE: (1.5e-21); KEGG: jan:Jann_2818 protein of unknown function DUF395, YeeE/YedE, ev=9e-39, 54% identity YP_611875.1 PFAM: protein of unknown function DUF395, YeeE/YedE: (6.4e-07); KEGG: jan:Jann_2817 protein of unknown function DUF395, YeeE/YedE, ev=2e-37, 57% identity YP_611876.1 PFAM: beta-lactamase-like: (3.2e-19); KEGG: jan:Jann_2816 beta-lactamase-like, ev=1e-122, 71% identity YP_611877.1 TIGRFAM: sulfate permease: (3.5e-132); PFAM: Sulfate transporter/antisigma-factor antagonist STAS: (9.4e-17) sulphate transporter: (3e-85); KEGG: sil:SPO1956 sulfate permease, ev=0.0, 66% identity YP_611878.1 KEGG: sil:SPO0045 phosphomethylpyrimidine kinase, ev=1e-101, 73% identity; TIGRFAM: Phosphomethylpyrimidine kinase type-2: (1.9e-128); PFAM: Phosphomethylpyrimidine kinase type-1: (5.2e-134) YP_611879.1 TIGRFAM: Glycine oxidase ThiO: (1.6e-82); PFAM: FAD dependent oxidoreductase: (2.4e-45); KEGG: sil:SPO0046 thiamine biosynthesis oxidoreductase ThiO, , ev=1e-145, 79% identity YP_611880.1 TIGRFAM: thiamine biosynthesis protein ThiS: (1.2e-23); PFAM: thiamineS: (3.9e-15); KEGG: sil:SPO0046.1 thiamine biosynthesis protein ThiS, ev=3e-16, 67% identity YP_611881.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_611882.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_611883.1 PFAM: UBA/THIF-type NAD/FAD binding fold: (4.3e-59) MoeZ/MoeB: (4.1e-13); KEGG: sil:SPO0049 thiamine biosynthesis protein ThiF, ev=1e-116, 66% identity YP_611884.1 PFAM: NLPA lipoprotein: (0.0025); KEGG: sil:SPO0050 ABC transporter, periplasmic substrate-binding protein, ev=1e-148, 82% identity YP_611885.1 PFAM: TENA/THI-4 protein: (5.6e-42); KEGG: sil:SPO0051 TENA/THI-4 family protein, ev=6e-96, 78% identity YP_611886.1 PFAM: ABC transporter related: (1.2e-49); SMART: ATPase: (1.3e-11); KEGG: sil:SPO0052 ABC transporter, ATP-binding protein, ev=3e-87, 69% identity YP_611887.1 PFAM: binding-protein-dependent transport systems inner membrane component: (3.6e-34); KEGG: sil:SPO0053 ABC transporter, permease protein, ev=1e-104, 80% identity YP_611888.1 PFAM: BioY protein: (2.7e-35); KEGG: plu:plu3847 unnamed protein product; similar to biotin synthase, ev=5e-53, 55% identity YP_611889.1 PFAM: cobalt transport protein: (2.2e-15); KEGG: plu:plu3848 unnamed protein product; similar to hypothetical proteins. transmembrane protein, ev=1e-50, 52% identity YP_611890.1 PFAM: SMC protein-like: (0.00011) ABC transporter related: (9.1e-51); SMART: ATPase: (8e-16); KEGG: dra:DR2469 cobalt transport system ATP-binding protein, ev=8e-78, 66% identity YP_611891.1 KEGG: sil:SPO0697 molybdate ABC transporter, ATP-binding protein, ev=1e-117, 59% identity; TIGRFAM: Molybdate ABC transporter, ATP-binding protein: (2.2e-144); PFAM: ABC transporter related: (2e-55) TOBE: (3.5e-11); SMART: ATPase: (1.5e-16) YP_611892.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_611893.1 TIGRFAM: molybdenum ABC transporter, periplasmic molybdate-binding protein: (2.4e-56); PFAM: extracellular solute-binding protein, family 1: (0.014); KEGG: sil:SPO0699 molybdate ABC transporter, periplasmic molybdate-binding protein, ev=8e-60, 53% identity YP_611894.1 KEGG: sil:SPO1811 hypothetical protein, ev=4e-35, 83% identity YP_611895.1 PFAM: Na+/solute symporter: (3.8e-16); KEGG: sil:SPO1810 sodium/solute symporter family protein, ev=0.0, 85% identity YP_611896.1 PFAM: cyclic nucleotide-binding: (4.6e-18) CBS: (7.9e-33) protein of unknown function DUF294, nucleotidyltransferase : (5.8e-172); KEGG: sil:SPO1809 nucleotidyltransferase/CBS/cyclic nucleotide-binding domain protein, ev=0.0, 64% identity YP_611897.1 KEGG: sil:SPO1808 hypothetical protein, ev=1e-52, 56% identity YP_611898.1 KEGG: sil:SPO1807 exonuclease, DNA polymerase III, epsilon subunit family, ev=1e-118, 49% identity; TIGRFAM: DNA polymerase III, epsilon subunit: (1.2e-22); PFAM: Exonuclease, RNase T and DNA polymerase III: (4.6e-44); SMART: Exonuclease: (7.8e-45) YP_611899.1 PFAM: alpha/beta hydrolase fold: (1.7e-17); KEGG: rba:RB4968 probable EphA protein-Mycobacterium tuberculosis (strain H37RV), ev=1e-122, 63% identity YP_611900.1 PFAM: protein of unknown function UPF0074: (0.0005) regulatory protein, DeoR: (0.00099) Helix-turn-helix, type 11: (2.2e-10); KEGG: rba:RB4967 probable DeoR-family transcriptional regulator, ev=2e-81, 65% identity YP_611901.1 PFAM: Alcohol dehydrogenase, zinc-binding: (4e-32) Alcohol dehydrogenase GroES-like: (2.4e-26); KEGG: sil:SPOA0430 oxidoreductase, zinc-binding dehydrogenase family, ev=1e-150, 74% identity YP_611902.1 PFAM: Mandelate racemase/muconate lactonizing enzyme-like: (3e-09); KEGG: sil:SPOA0428 mandelate racemase/muconate lactonizing enzyme family protein, ev=0.0, 82% identity YP_611903.1 PFAM: regulatory protein, ArsR: (4.1e-10); KEGG: sil:SPOA0427 transcriptional regulator, ArsR family, ev=5e-23, 61% identity YP_611904.1 PFAM: fumarylacetoacetate (FAA) hydrolase: (1.9e-87); KEGG: sme:SMb21112 bifunctional enzyme 2-hydroxyhepta-2,4-diene-1,7-dioatesomerase 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioatedecarboxylase protein, ev=3e-99, 63% identity YP_611905.1 PFAM: cyclic nucleotide-binding: (2e-15) ABC transporter, transmembrane region: (1.4e-05); KEGG: sil:SPO0574 ABC transporter, transmembrane ATP-binding protein, , ev=0.0, 67% identity YP_611906.1 KEGG: sil:SPO0573 hypothetical protein, ev=2e-38, 56% identity YP_611907.1 PFAM: ThiJ/PfpI: (5.3e-07); KEGG: cvi:CV2336 probable ThiJ/PfpI family protein, ev=9e-39, 46% identity YP_611908.1 PFAM: regulatory proteins, AsnC/Lrp: (4.8e-29) regulatory protein, ArsR: (0.0025) Helix-turn-helix, type 11: (0.00089); KEGG: sil:SPO0569 transcriptional regulator, AsnC family, ev=3e-58, 74% identity YP_611909.1 catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates YP_611910.1 PFAM: regulatory protein, TetR: (1.1e-09); KEGG: sil:SPO0566 transcriptional regulator, TetR family, ev=1e-64, 58% identity YP_611911.1 KEGG: ret:RHE_PE00042 probable oligopeptide ABC transporter, ATP-binding protein, ev=1e-143, 47% identity; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein-like: (7.5e-08); PFAM: ABC transporter related: (8.4e-51) Oligopeptide/dipeptide ABC transporter-like: (7.6e-08); SMART: ATPase: (2.3e-17) YP_611912.1 PFAM: extracellular solute-binding protein, family 5: (1e-35); KEGG: sil:SPO0560 oligopeptide ABC transporter, periplasmic oligopeptide-binding protein, ev=0.0, 72% identity YP_611913.1 PFAM: binding-protein-dependent transport systems inner membrane component: (2.5e-24); KEGG: sil:SPO0559 oligopeptide ABC transporter, permease protein, ev=1e-167, 84% identity YP_611914.1 PFAM: binding-protein-dependent transport systems inner membrane component: (4.7e-38); KEGG: sil:SPO0558 oligopeptide ABC transporter, permease protein, ev=0.0, 86% identity YP_611915.1 PFAM: L-carnitine dehydratase/bile acid-inducible protein F: (8e-09); KEGG: sil:SPO0264 CaiB/BaiF family protein, ev=1e-147, 62% identity YP_611916.1 PFAM: MscS Mechanosensitive ion channel: (5.7e-48); KEGG: sil:SPO0557 mechanosensitive ion channel family protein, ev=0.0, 62% identity YP_611917.1 KEGG: sil:SPO0555 hypothetical protein, ev=1e-176, 77% identity YP_611918.1 PFAM: glycosyl transferase, group 1: (1.9e-34); KEGG: sil:SPO0554 glycosyl transferase, group 1 family protein, ev=1e-169, 74% identity YP_611919.1 PFAM: glycosyl transferase, group 1: (4.1e-17); KEGG: sil:SPO0553 glycosyltransferase, group 1, ev=1e-112, 61% identity YP_611920.1 PFAM: Phosphoglycerate mutase: (3e-31); KEGG: sil:SPO0552 phosphoglycerate mutase family protein, ev=1e-74, 71% identity YP_611921.1 KEGG: sil:SPO0551 hypothetical protein, ev=1e-130, 64% identity YP_611922.1 KEGG: sil:SPO0550 hypothetical protein, ev=6e-79, 57% identity YP_611923.1 KEGG: sil:SPO0549 hypothetical protein, ev=2e-62, 72% identity YP_611924.1 TIGRFAM: Phosphonate metabolism PhnM: (8.1e-151); PFAM: amidohydrolase: (0.041) Amidohydrolase 3: (0.0013); KEGG: sil:SPO0476 alkylphosphonate utilization protein PhnM, ev=1e-156, 72% identity YP_611925.1 PFAM: protein of unknown function DUF1045: (3e-47); KEGG: sil:SPO0475 hypothetical protein, ev=2e-81, 65% identity YP_611926.1 TIGRFAM: Phosphonate metabolism, 1,5-bisphosphokinase (PRPP-forming) PhnN: (2.8e-49); SMART: Guanylate kinase/L-type calcium channel region: (3e-08); KEGG: sil:SPO0474 alkylphosphonate utilization protein PhnN, ev=3e-51, 61% identity YP_611927.1 KEGG: sil:SPO0473 alkylphosphonate utilization protein PhnL, ev=1e-94, 77% identity; TIGRFAM: Phosphonate C-P lyase system, PhnL: (3.9e-139); PFAM: ABC transporter related: (5.7e-53); SMART: ATPase: (3e-11) YP_611928.1 KEGG: sil:SPO0472 alkylphosphonate utilization protein PhnK, ev=1e-126, 88% identity; TIGRFAM: Phosphonate C-P lyase system, PhnK: (1.1e-156); PFAM: ABC transporter related: (1.6e-57); SMART: ATPase: (9.1e-20) YP_611929.1 PFAM: phosphonate metabolism PhnJ: (1e-209); KEGG: sil:SPO0471 alkylphosphonate utilization protein PhnJ, ev=1e-146, 91% identity YP_611930.1 PFAM: phosphonate metabolism: (8.1e-225); KEGG: sil:SPO0470 alkylphosphonate utilization protein PhnI, ev=1e-176, 85% identity YP_611931.1 KEGG: sil:SPO0469 alkylphosphonate utilization protein PhnH, ev=5e-59, 60% identity YP_611932.1 PFAM: phosphonate metabolism PhnG: (2.3e-68); KEGG: sil:SPO0468 alkylphosphonate utilization protein PhnG, ev=1e-42, 59% identity YP_611933.1 TIGRFAM: Phosphonate C-P lyase system, transcriptional regulator PhnF: (2.2e-76); PFAM: regulatory protein GntR, HTH: (1.1e-18) protein of unknown function UPF0074: (0.0007) UbiC transcription regulator-associated: (9.1e-36) Helix-turn-helix, type 11: (0.0041); KEGG: sil:SPO0467 transcriptional regulator, GntR family, ev=2e-80, 61% identity YP_611934.1 PFAM: transferase hexapeptide repeat: (0.031); KEGG: sil:SPO0784 chloramphenicol acetyltransferase, , ev=7e-95, 79% identity YP_611935.1 TIGRFAM: Phosphonate uptake transporter: (7.5e-36); PFAM: binding-protein-dependent transport systems inner membrane component: (3.2e-11); KEGG: sil:SPO0783 phosphonate ABC transporter, permease protein, ev=0.0, 77% identity YP_611936.1 TIGRFAM: Phosphonate uptake transporter: (2.3e-73); PFAM: binding-protein-dependent transport systems inner membrane component: (2.3e-13); KEGG: sil:SPO0782 phosphonate ABC transporter, permease protein, ev=1e-129, 79% identity YP_611937.1 TIGRFAM: Phosphonate-binding periplasmic protein: (8.4e-86); KEGG: sil:SPO0781 phosphonate ABC transporter, periplasmic phosphonate-binding protein, ev=1e-145, 83% identity YP_611938.1 KEGG: sil:SPO0780 phosphonate ABC transporter, ATP-binding protein, ev=1e-124, 86% identity; TIGRFAM: Phosphonate ABC transporter PhnC, ATP-binding: (2.3e-131); PFAM: ABC transporter related: (3.2e-56); SMART: ATPase: (2.2e-11) YP_611939.1 PFAM: ribulose-phosphate 3-epimerase: (3.2e-106); KEGG: sil:SPO0779 ribulose-phosphate 3-epimerase, ev=1e-114, 90% identity YP_611940.1 KEGG: sil:SPO0776 conserved hypothetical protein TIGR00369, ev=5e-16, 49% identity YP_611941.1 PFAM: protein of unknown function UPF0261: (3e-144); KEGG: sil:SPOA0356 hypothetical protein, ev=1e-175, 74% identity YP_611942.1 PFAM: aldehyde dehydrogenase: (3e-218); KEGG: jan:Jann_3507 aldehyde dehydrogenase, ev=0.0, 68% identity YP_611943.1 PFAM: protein of unknown function DUF112, transmembrane: (3.1e-111); KEGG: sil:SPO0771 membrane protein, ev=0.0, 83% identity YP_611944.1 KEGG: sil:SPO0770 hypothetical protein, ev=3e-62, 59% identity YP_611945.1 PFAM: Uncharacterized protein UPF0065: (6.2e-09); KEGG: sil:SPO0769 hypothetical protein, ev=1e-155, 85% identity YP_611946.1 PFAM: regulatory proteins, IclR: (1.2e-15); KEGG: sil:SPO0768 transcriptional regulator, IclR family, ev=4e-89, 63% identity YP_611947.1 PFAM: aminotransferase class-III: (1.2e-110); KEGG: jan:Jann_3512 aminotransferase class-III, ev=0.0, 78% identity YP_611948.1 TIGRFAM: Methyltransferase FkbM: (1.7e-15); KEGG: sil:SPO0767 methyltransferase, FkbM family, ev=2e-82, 68% identity YP_611949.1 PFAM: glutamine synthetase, catalytic region: (3.5e-56); KEGG: sil:SPO0765 glutamine synthetase family protein, ev=0.0, 84% identity YP_611950.1 PFAM: cytochrome P450: (2.1e-06); KEGG: sil:SPO0764 cytochrome P450 family protein, ev=0.0, 84% identity YP_611951.1 PFAM: glutamine amidotransferase class-I: (0.00033); KEGG: sil:SPO0763 glutamine amidotransferase, class I, ev=5e-75, 58% identity YP_611952.1 PFAM: regulatory protein GntR, HTH: (3.2e-16) GntR-like: (3.1e-23); KEGG: sil:SPO0762 transcriptional regulator, GntR family, ev=2e-81, 71% identity YP_611953.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA YP_611954.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation YP_611955.1 TIGRFAM: Phenylacetate-CoA oxygenase, PaaI subunit: (5.4e-114); PFAM: phenylacetic acid catabolic: (1.1e-56); KEGG: sil:SPO0755 phenylacetic acid degradation protein PaaI, ev=1e-116, 79% identity YP_611956.1 TIGRFAM: Phenylacetate-CoA oxygenase, PaaJ subunit: (2.8e-76); PFAM: protein of unknown function DUF59: (6.3e-24); KEGG: sil:SPO0754 phenylacetic acid degradation protein PaaJ, ev=4e-67, 71% identity YP_611957.1 PFAM: ferredoxin: (7.2e-25) oxidoreductase FAD/NAD(P)-binding: (3.7e-17) Oxidoreductase FAD-binding region: (4.3e-09); KEGG: sil:SPO0753 phenylacetic acid degradation oxidoreductase PaaK, ev=1e-158, 76% identity YP_611958.1 PFAM: aminotransferase, class IV: (4.4e-26); KEGG: sil:SPO0388 aminotransferase, class IV, ev=1e-125, 74% identity YP_611959.1 PFAM: UspA: (2.3e-16); KEGG: sil:SPO0386 universal stress family protein, ev=7e-72, 83% identity YP_611960.1 KEGG: sil:SPO0333 lipoprotein, , ev=8e-11, 49% identity YP_611961.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_611962.1 PFAM: Redoxin: (3.4e-15); KEGG: sil:SPO0331 thiol:disulfide interchange protein, , ev=5e-63, 64% identity YP_611963.1 PFAM: EAL: (6.5e-41); KEGG: sil:SPO0327 EAL domain protein, ev=4e-97, 63% identity YP_611964.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_611965.1 TIGRFAM: Acetoacetyl-CoA reductase: (5e-153); PFAM: short-chain dehydrogenase/reductase SDR: (2.8e-28); KEGG: jan:Jann_0492 acetoacetyl-CoA reductase, ev=1e-115, 84% identity YP_611966.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_611967.1 PFAM: protein of unknown function DUF6, transmembrane: (4.2e-07); KEGG: sil:SPO0323 membrane protein, , ev=1e-124, 76% identity YP_611968.1 PFAM: protein of unknown function DUF465: (5.8e-05); KEGG: sil:SPO0322 hypothetical protein, ev=1e-12, 64% identity YP_611969.1 PFAM: methyltransferase small: (3.3e-05); KEGG: sil:SPO0321 hypothetical protein, ev=1e-89, 64% identity YP_611970.1 KEGG: sil:SPO0320 hypothetical protein, ev=4e-22, 71% identity YP_611971.1 PFAM: Polyprenyl synthetase: (1.2e-82); KEGG: sil:SPO0319 decaprenyl diphosphate synthase, ev=1e-151, 84% identity YP_611972.1 KEGG: rsp:RSP_1779 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, ev=7e-69, 54% identity; TIGRFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase: (3.7e-18); PFAM: GHMP kinase: (1.1e-06) YP_611973.1 PFAM: TPR repeat: (0.32) Tetratricopeptide TPR_2: (0.0014); SMART: Tetratricopeptide region: (0.021); KEGG: sil:SPO0317 TPR domain protein, ev=0.0, 63% identity YP_611974.1 PFAM: FAD dependent oxidoreductase: (2.5e-05) electron transfer flavoprotein-ubiquinone oxidoreductase: (2.7e-99); KEGG: sil:SPO0316 electrotransfer ubiquinone oxidoreductase family protein, ev=0.0, 90% identity YP_611975.1 TIGRFAM: redox-sensitive transcriptional activator SoxR: (2.8e-64); PFAM: regulatory protein, MerR: (1.2e-08); KEGG: sil:SPO0314 redox-sensitive transcriptional activator SoxR, ev=4e-55, 68% identity YP_611976.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (3.8e-13); KEGG: sil:SPO0313 glyoxalase family protein, ev=4e-42, 60% identity YP_611977.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_611978.1 KEGG: sil:SPO0311 hypothetical protein, ev=1e-101, 62% identity YP_611979.1 PFAM: GCN5-related N-acetyltransferase: (6.4e-16); KEGG: rsp:RSP_0613 hypothetical protein, ev=1e-51, 57% identity YP_611980.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum YP_611981.1 KEGG: sil:SPO0309 hypothetical protein, ev=1e-100, 66% identity YP_611982.1 TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B: (3.9e-66); PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region: (3.9e-32); KEGG: sil:SPO0308 molybdopterin-guanine dinucleotide biosynthesis protein B, ev=2e-65, 76% identity YP_611983.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_611985.1 TIGRFAM: formate dehydrogenase family accessory protein FdhD: (3e-36); PFAM: formate dehydrogenase, subunit FdhD: (1.1e-22); KEGG: sil:SPO0306 formate dehydrogenase accessory protein FdhD, ev=1e-129, 81% identity YP_611986.1 PFAM: AzlC-like: (5.6e-48); KEGG: sil:SPO0305 AzlC family protein, ev=1e-82, 64% identity YP_611987.1 PFAM: branched-chain amino acid transport: (2.7e-10); KEGG: jan:Jann_0460 branched-chain amino acid transport, ev=5e-22, 44% identity YP_611988.1 KEGG: sil:SPO0304 lipoprotein, , ev=4e-61, 56% identity YP_611990.1 PFAM: protein of unknown function DUF6, transmembrane: (4e-07); KEGG: jan:Jann_0131 protein of unknown function DUF6, transmembrane, ev=3e-89, 52% identity YP_611991.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_611992.1 PFAM: Endonuclease/exonuclease/phosphatase: (9.5e-05); KEGG: sil:SPO0213 hypothetical protein, ev=2e-79, 47% identity YP_611993.1 KEGG: sil:SPO0214 membrane protein, , ev=3e-76, 52% identity YP_611994.1 PFAM: binding-protein-dependent transport systems inner membrane component: (0.0008); KEGG: sil:SPO1789 sulfate/tungstate uptake family ABC transporter, permease protein, ev=1e-79, 68% identity YP_611995.1 PFAM: ABC transporter related: (1.4e-53); SMART: ATPase: (2.4e-19); KEGG: mag:amb3045 ABC-type polar amino acid transport system, ATPase component, ev=3e-55, 51% identity YP_611996.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_611997.1 binds the polymerase to DNA and acts as a sliding clamp YP_611998.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_611999.1 PFAM: Lysine exporter protein (LYSE/YGGA): (3e-09); KEGG: sil:SPO0152 transporter, LysE family, ev=2e-76, 67% identity YP_612000.1 PFAM: regulatory protein, TetR: (5.9e-13); KEGG: sil:SPO0153 transcriptional regulator, TetR family, ev=2e-57, 58% identity YP_612001.1 PFAM: NAD(P)H dehydrogenase (quinone): (1.6e-09) NADPH-dependent FMN reductase: (0.00055); KEGG: sil:SPO0154 NAD(P)H dehydrogenase, quinone family, ev=1e-75, 65% identity YP_612002.1 negatively supercoils closed circular double-stranded DNA YP_612003.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_612004.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_612005.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_612006.1 PFAM: 2OG-Fe(II) oxygenase: (2.2e-08); KEGG: sil:SPO0042 alkylated DNA repair protein, , ev=8e-75, 68% identity YP_612007.1 KEGG: sil:SPO0040 ABC transporter, permease protein, ev=1e-103, 63% identity YP_612008.1 TIGRFAM: 3'(2'),5'-bisphosphate nucleotidase: (4.7e-88); PFAM: inositol monophosphatase: (1.1e-56); KEGG: sil:SPO0039 3'(2'),5'-bisphosphate nucleotidase, ev=1e-118, 79% identity YP_612009.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_612010.1 TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase: (3.1e-138); PFAM: Nucleotidyl transferase: (1.7e-12); KEGG: jan:Jann_0218 UTP-glucose-1-phosphate uridylyltransferase, ev=1e-126, 75% identity YP_612011.1 TIGRFAM: UDP-glucose 4-epimerase: (4.1e-160); PFAM: NAD-dependent epimerase/dehydratase: (5.1e-74) 3-beta hydroxysteroid dehydrogenase/isomerase: (7.7e-09) polysaccharide biosynthesis protein CapD: (1.7e-05) dTDP-4-dehydrorhamnose reductase: (2.2e-05); KEGG: rsp:RSP_0652 UDP-glucose 4-epimerase, ev=1e-124, 67% identity YP_612012.1 KEGG: sil:SPO0037 hypothetical protein, ev=1e-109, 57% identity YP_612013.1 KEGG: sil:SPO0036 hypothetical protein, ev=1e-147, 73% identity YP_612014.1 PFAM: glycosyl transferase, family 14: (7.8e-05); KEGG: sil:SPO0035 core-2/I-branching enzyme family protein, ev=0.0, 74% identity YP_612015.1 KEGG: sil:SPO0034 hypothetical protein, ev=0.0, 65% identity YP_612016.1 PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2: (1.6e-16); KEGG: sil:SPO0077 PTS IIA-like nitrogen-regulatory protein PtsN, ev=2e-58, 74% identity YP_612017.1 TIGRFAM: ribosomal subunit interface protein: (4e-19); PFAM: sigma 54 modulation protein/ribosomal protein S30EA: (5.5e-27); KEGG: sil:SPO0078 ribosomal subunit interface protein, , ev=2e-87, 83% identity YP_612019.1 PFAM: ABC transporter related: (3.8e-65); SMART: ATPase: (1.7e-13); KEGG: sil:SPO0079 ABC transporter, ATP-binding protein, ev=1e-122, 87% identity YP_612020.1 PFAM: OstA-like protein: (2.9e-26); KEGG: sil:SPO0080 hypothetical protein, ev=5e-37, 56% identity YP_612021.1 KEGG: sil:SPO0081 hypothetical protein, ev=2e-50, 51% identity YP_612022.1 PFAM: 3'-5' exonuclease: (4.8e-36); KEGG: sil:SPO0083 exonuclease, , ev=1e-98, 83% identity YP_612023.1 TIGRFAM: xylulokinase: (4.1e-214); PFAM: carbohydrate kinase, FGGY: (2.2e-90); KEGG: sil:SPO0855 xylulokinase, ev=1e-173, 62% identity YP_612024.1 catalyzes the interconversion of D-xylose to D-xylulose YP_612025.1 PFAM: Aldose 1-epimerase: (1.6e-57); KEGG: sil:SPO0857 aldose 1-epimerase, ev=3e-63, 42% identity YP_612026.1 KEGG: sil:SPO0858 methylamine utilization protein MauG, , ev=1e-152, 65% identity YP_612027.1 PFAM: phospholipase D/Transphosphatidylase: (1.5e-05); KEGG: bbr:BB0822 phospholipase D protein, ev=1e-112, 46% identity YP_612028.1 PFAM: sodium/hydrogen exchanger: (1.4e-14); KEGG: hch:HCH_01176 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain, ev=4e-75, 42% identity YP_612029.1 PFAM: ABC transporter related: (1e-61); SMART: ATPase: (2.3e-18); KEGG: sil:SPO1547 peptide/opine/nickel uptake family ABC transporter, ATP-binding protein, ev=4e-89, 69% identity YP_612030.1 PFAM: ABC transporter related: (1.2e-51); SMART: ATPase: (1.6e-17); KEGG: sil:SPO1546 peptide/opine/nickel uptake family ABC transporter, ATP-binding protein, ev=1e-127, 79% identity YP_612031.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.5e-41); KEGG: sil:SPO1545 peptide/opine/nickel uptake family ABC transporter, permease protein, ev=1e-147, 84% identity YP_612032.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.7e-47); KEGG: sil:SPO1544 peptide/opine/nickel uptake family ABC transporter, permease protein, ev=1e-156, 78% identity YP_612033.1 PFAM: extracellular solute-binding protein, family 5: (6.6e-78); KEGG: sil:SPO1543 peptide/opine/nickel uptake family ABC transporter, periplasmic substrate-binding protein, ev=0.0, 69% identity YP_612034.1 PFAM: peptidase M19, renal dipeptidase: (2.4e-119); KEGG: sil:SPO1542 renal dipeptidase family protein, ev=1e-118, 61% identity YP_612035.1 PFAM: Alcohol dehydrogenase, zinc-binding: (2.8e-36) Alcohol dehydrogenase GroES-like: (1.9e-38); KEGG: ret:RHE_CH01189 probable alcohol dehydrogenase protein, ev=1e-139, 67% identity YP_612036.1 PFAM: glucose-inhibited division protein A: (0.0015) fumarate reductase/succinate dehydrogenase flavoprotein-like: (0.0027) HI0933-like protein: (5e-102); KEGG: sil:SPO3436 hypothetical protein, ev=1e-149, 68% identity YP_612037.1 PFAM: glutathione S-transferase-like: (1.3e-08); KEGG: jan:Jann_0408 glutathione S-transferase-like, ev=3e-60, 59% identity YP_612038.1 PFAM: DNA polymerase III, delta: (6.8e-05); KEGG: sil:SPO3434 DNA polymerase III delta subunit, ev=1e-147, 75% identity YP_612039.1 KEGG: sil:SPO3433 lipoprotein, , ev=8e-35, 50% identity YP_612040.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_612041.1 KEGG: sil:SPO3431 hypothetical protein, ev=3e-48, 61% identity YP_612042.1 KEGG: sil:SPO3430 outer membrane porin, ev=6e-30, 34% identity YP_612043.1 TIGRFAM: Protein of unknown function UPF0001: (9.3e-45); PFAM: alanine racemase-like: (7e-09); KEGG: sil:SPO3429 alanine racemase domain protein, ev=3e-99, 82% identity YP_612044.1 KEGG: sil:SPO3428 hypothetical protein, ev=6e-62, 72% identity YP_612045.1 PFAM: GTP cyclohydrolase II: (4.5e-90); KEGG: sil:SPO3427 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II, ev=1e-145, 71% identity YP_612046.1 PFAM: response regulator receiver: (6.9e-38) transcriptional regulatory protein-like: (1.4e-18); KEGG: sil:SPO3426 DNA-binding response regulator, ev=1e-117, 92% identity YP_612047.1 PFAM: Taurine catabolism dioxygenase TauD/TfdA: (3.9e-28); KEGG: pfo:Pfl_5234 gamma-butyrobetaine hydroxylase, ev=9e-69, 39% identity YP_612048.1 TIGRFAM: exodeoxyribonuclease III: (1.5e-45) exodeoxyribonuclease III (xth): (5.2e-45); PFAM: Endonuclease/exonuclease/phosphatase: (1.8e-39); KEGG: sil:SPO3425 exodeoxyribonuclease III, , ev=1e-130, 82% identity YP_612049.1 PFAM: Tetratricopeptide TPR_4: (0.016) Thioredoxin domain: (9e-22); KEGG: sil:SPO3423 thioredoxin, ev=1e-125, 75% identity YP_612050.1 PFAM: peptidase S16, lon-like: (2.4e-06); KEGG: rsp:RSP_1490 ATP-dependent protease La, LON, ev=2e-86, 73% identity YP_612051.1 PFAM: protein of unknown function DUF343: (2e-16); KEGG: sil:SPO3421 hypothetical protein, ev=5e-20, 78% identity YP_612052.1 TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family: (2.4e-168); PFAM: monooxygenase, FAD-binding: (4.1e-10); KEGG: sil:SPO3419 ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family, ev=1e-167, 70% identity YP_612053.1 PFAM: Amidase: (1.7e-76); KEGG: sil:SPO3418 amidase family protein, ev=1e-180, 73% identity YP_612054.1 PFAM: aminotransferase, class I and II: (7e-33); KEGG: sil:SPO3417 aminotransferase, classes I and II, ev=0.0, 78% identity YP_612055.1 PFAM: cell divisionFtsK/SpoIIIE: (1.4e-78); KEGG: sil:SPO3416 FtsK/SpoIIIE family protein, ev=0.0, 68% identity YP_612056.1 PFAM: outer membrane lipoprotein carrier protein LolA: (1e-14); KEGG: sil:SPO3415 outer membrane lipoprotein carrier protein LolA, , ev=5e-58, 59% identity YP_612057.1 KEGG: sil:SPO3414 lipoprotein, , ev=9e-76, 65% identity YP_612058.1 TIGRFAM: Hemimethylated DNA-binding region: (1.9e-50); KEGG: sil:SPO3412 hypothetical protein, ev=1e-48, 79% identity YP_612059.1 PFAM: gamma-glutamyltranspeptidase: (1.2e-171); KEGG: sil:SPO3411 gamma-glutamyltranspeptidase, , ev=0.0, 74% identity YP_612060.1 PFAM: ATP-binding region, ATPase-like: (0.00013); KEGG: sil:SPO3410 anti-sigma B factor, , ev=5e-37, 54% identity YP_612061.1 TIGRFAM: anti-anti-sigma factor: (1.8e-12); PFAM: Sulfate transporter/antisigma-factor antagonist STAS: (9.8e-21); KEGG: sil:SPO3409 anti-anti-sigma factor, ev=4e-40, 78% identity YP_612062.1 PFAM: Thiolase: (1.6e-116); KEGG: sil:SPO3408 acetyl-CoA C-acetyltransferase, ev=0.0, 87% identity YP_612063.1 SMART: GAF: (3.9e-06); KEGG: jan:Jann_4049 GAF sensor protein, ev=3e-61, 73% identity YP_612064.1 PFAM: Lysine exporter protein (LYSE/YGGA): (1.2e-07); KEGG: sil:SPO3402 transporter, LysE family, ev=2e-88, 79% identity YP_612065.1 PFAM: glutathione-dependent formaldehyde-activating, GFA: (1.5e-22); KEGG: sil:SPO3401 hypothetical protein, ev=4e-47, 72% identity YP_612066.1 TIGRFAM: rarD protein: (6.3e-57); PFAM: protein of unknown function DUF6, transmembrane: (8.6e-12); KEGG: sil:SPO3395 RarD, ev=1e-115, 69% identity YP_612067.1 PFAM: pseudouridine synthase: (8.2e-50); KEGG: sil:SPO3392 ribosomal large subunit pseudouridine synthase A, ev=5e-95, 76% identity YP_612068.1 PFAM: helix-turn-helix, AraC type: (1.5e-08); KEGG: pst:PSPTO3805 transcriptional regulator, AraC family, ev=5e-11, 43% identity YP_612069.1 PFAM: aldehyde dehydrogenase: (3.7e-208); KEGG: sil:SPO3382 aldehyde dehydrogenase family protein, ev=0.0, 86% identity YP_612070.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen: (1.2e-73) Redoxin: (0.00011); KEGG: sil:SPO3383 thiol-specific antioxidant protein, ev=2e-93, 76% identity YP_612071.1 KEGG: jan:Jann_4277 lipopolysaccharide biosynthesis protein-like, ev=3e-32, 35% identity YP_612072.1 PFAM: glycosyl transferase, family 2: (3.9e-21); KEGG: atc:AGR_L_533 dTDP-Rha:a-D-GlcNAc-diphosphoryl polyprenol, A-3-L-rhamnosyl transferase, ev=6e-61, 46% identity YP_612073.1 KEGG: sil:SPO3389 polyribonucleotide nucleotidyltransferase, ev=0.0, 89% identity; PFAM: 3' exoribonuclease: (2.5e-47) RNA binding S1: (1.2e-24) KH, type 1: (1.3e-15); SMART: KH: (1.1e-13) YP_612074.1 KEGG: jan:Jann_2252 hypothetical protein, ev=6e-11, 55% identity YP_612075.1 PFAM: cobalamin synthesis protein, P47K: (3e-91) cobalamin synthesis CobW-like: (3.1e-34); KEGG: jan:Jann_2254 cobalamin synthesis protein, P47K, ev=0.0, 78% identity YP_612076.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_612077.1 KEGG: sil:SPO3839 type I secretion target repeat protein, ev=6e-63, 40% identity YP_612078.1 PFAM: protein of unknown function DUF1643: (4.2e-41); KEGG: sil:SPO3838 hypothetical protein, ev=3e-68, 71% identity YP_612079.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_612080.1 KEGG: sil:SPO3836 hypothetical protein, ev=1e-88, 68% identity YP_612081.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_612082.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_612083.1 PFAM: protein of unknown function DUF1674: (2.5e-22); KEGG: sil:SPO3377 hypothetical protein, ev=1e-19, 87% identity YP_612084.1 PFAM: Fmu (Sun): (1.3e-39) NusB/RsmB/TIM44: (2.1e-07) methyltransferase small: (0.00033) Methyltransferase type 11: (4.5e-05); KEGG: sil:SPO3376 ribosomal RNA small subunit methyltransferase B, , ev=1e-164, 70% identity YP_612085.1 PFAM: Heparinase II/III-like: (1.7e-14); KEGG: sil:SPO3375 hypothetical protein, ev=0.0, 72% identity YP_612086.1 involved in de novo purine biosynthesis YP_612087.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_612088.1 KEGG: sil:SPO3372 hypothetical protein, ev=3e-39, 46% identity YP_612089.1 PFAM: peptidase M16-like: (7.5e-35); KEGG: sil:SPO3371 peptidase, M16 family, ev=0.0, 74% identity YP_612090.1 PFAM: peptidase M16-like: (1.8e-39); KEGG: sil:SPO3370 peptidase, M16 family, ev=1e-157, 63% identity YP_612091.1 PFAM: aldehyde dehydrogenase: (1.2e-201); KEGG: sil:SPO3368 aldehyde dehydrogenase family protein, ev=0.0, 78% identity YP_612092.1 KEGG: jan:Jann_0789 deoxyribose-phosphate aldolase, ev=1e-143, 77% identity; TIGRFAM: deoxyribose-phosphate aldolase: (7.9e-38); PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase: (4.7e-39) YP_612093.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.078); PFAM: periplasmic solute binding protein: (9e-94); KEGG: sil:SPO3366 zinc/manganese/iron ABC transporter, periplasmic zinc/manganese/iron-binding protein, ev=1e-124, 73% identity YP_612094.1 PFAM: ABC transporter related: (2.6e-51); SMART: ATPase: (2.9e-16); KEGG: sil:SPO3365 zinc/manganese/iron ABC transporter, ATP-binding protein, ev=1e-116, 80% identity YP_612095.1 PFAM: ABC-3: (2.2e-59); KEGG: sil:SPO3364 zinc/manganese/iron ABC transporter, permease protein, ev=1e-178, 81% identity YP_612096.1 PFAM: ABC-3: (5.6e-26); KEGG: sil:SPO3363 zinc/manganese/iron ABC transporter, permease protein, ev=1e-143, 84% identity YP_612097.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_612098.1 PFAM: protein of unknown function DUF195: (7.5e-73); KEGG: sil:SPO3361 RmuC domain protein, ev=1e-166, 73% identity YP_612099.1 PFAM: adenylyl cyclase class-3/4/guanylyl cyclase: (2.1e-14); KEGG: sme:SMa1103 probable adenylate cyclase, ev=2e-64, 36% identity YP_612100.1 KEGG: sil:SPO3310 hypothetical protein, ev=2e-27, 58% identity YP_612101.1 PFAM: Saccharopine dehydrogenase: (4.1e-54) 6-phosphogluconate dehydrogenase, NAD-binding: (0.0007); KEGG: sil:SPO3309 saccharopine dehydrogenase, , ev=1e-172, 75% identity YP_612102.1 PFAM: alanine dehydrogenase/PNT-like: (0.00018); KEGG: sil:SPO3307 saccharopine dehydrogenase, , ev=1e-171, 84% identity YP_612103.1 PFAM: glutathione S-transferase-like: (7.7e-07); KEGG: sil:SPO3306 glutathione S-transferase, , ev=5e-73, 67% identity YP_612104.1 PFAM: Phosphoglycerate mutase: (1.4e-20); KEGG: sil:SPO3305 phosphoglycerate mutase family protein, ev=6e-82, 66% identity YP_612105.1 KEGG: rsp:RSP_1085 hypothetical protein, ev=5e-10, 54% identity YP_612106.1 PFAM: response regulator receiver: (9.6e-31) transcriptional regulatory protein-like: (1.3e-16); KEGG: sil:SPO3298 DNA-binding response regulator, ev=1e-113, 88% identity YP_612107.1 TIGRFAM: PAS: (0.0022); PFAM: response regulator receiver: (2.5e-05) ATP-binding region, ATPase-like: (7.6e-29) histidine kinase A-like: (0.0016) PAS fold-4: (7.3e-06); KEGG: sil:SPO3297 sensory box histidine kinase/response regulator, ev=0.0, 69% identity YP_612108.1 PFAM: AMP-dependent synthetase and ligase: (7.4e-70); KEGG: sil:SPO3296 AMP-binding enzyme, ev=0.0, 79% identity YP_612109.1 PFAM: ABC transporter related: (2.1e-46); SMART: ATPase: (6.8e-10); KEGG: sil:SPO3295 branched-chain amino acid ABC transporter, ATP-binding protein, ev=1e-140, 91% identity YP_612110.1 PFAM: inner-membrane translocator: (1.4e-07); KEGG: sil:SPO3294 branched-chain amino acid ABC transporter, permease protein, ev=1e-172, 92% identity YP_612112.1 KEGG: sil:SPO3293 hypothetical protein, ev=6e-19, 53% identity YP_612113.1 PFAM: inner-membrane translocator: (1.8e-21); KEGG: sil:SPO3292 branched-chain amino acid ABC transporter, permease protein, ev=0.0, 90% identity YP_612114.1 KEGG: sil:SPO3291 branched-chain amino acid ABC transporter, periplasmic branched-chain amino acid binding protein, , ev=0.0, 78% identity YP_612115.1 PFAM: ABC transporter related: (8.6e-31); SMART: ATPase: (9.6e-09); KEGG: sil:SPO3290 branched-chain amino acid ABC transporter, ATP-binding protein, ev=1e-140, 89% identity YP_612116.1 KEGG: sil:SPO3289 phenylacetate-CoA ligase, , ev=0.0, 84% identity YP_612117.1 PFAM: binding-protein-dependent transport systems inner membrane component: (9.2e-13); KEGG: sil:SPO3288 ferric iron ABC transporter, permease protein, ev=0.0, 77% identity YP_612118.1 PFAM: cobalamin synthesis protein, P47K: (2.5e-44); KEGG: jan:Jann_3251 cobalamin synthesis protein, P47K, ev=3e-64, 44% identity YP_612119.1 PFAM: extracellular solute-binding protein, family 1: (1.8e-11); KEGG: sil:SPO3287 ferric iron ABC transporter, periplasmic ferric iron-binding protein, ev=1e-149, 75% identity YP_612120.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_612121.1 PFAM: N-formylglutamate amidohydrolase: (2.6e-59); KEGG: rsp:RSP_1399 hypothetical protein, ev=2e-92, 57% identity YP_612122.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_612123.1 PFAM: NUDIX hydrolase: (1.9e-16); KEGG: sil:SPO3279 NUDIX domain protein, ev=2e-38, 58% identity YP_612124.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_612125.1 PFAM: AAA ATPase, central region: (8e-12) Clp, N terminal: (2.9e-07) ATPase associated with various cellular activities, AAA_5: (2.3e-05) ATPase AAA-2: (4.2e-108); SMART: ATPase: (1.5e-14); KEGG: sil:SPO3276 ATP-dependent Clp protease, ATP-binding subunit ClpB, ev=0.0, 85% identity YP_612126.1 PFAM: ferredoxin-dependent glutamate synthase: (1.7e-82); KEGG: sil:SPO3272 glutamate synthase family protein, ev=0.0, 68% identity YP_612128.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_612129.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_612131.1 PFAM: response regulator receiver: (5.3e-09); KEGG: lic:LIC13330 response regulator, ev=4e-13, 32% identity YP_612132.1 PFAM: ATP-binding region, ATPase-like: (4.7e-28) histidine kinase A-like: (1.1e-09); KEGG: rpa:RPA3016 bacteriophytochrome (light-regulated signal transduction histidine kinase), PhyB2, ev=1e-38, 33% identity YP_612133.1 KEGG: nfa:nfa32140 sigma activity regulating serine phosphatase, ev=9e-11, 25% identity YP_612134.1 PFAM: ATP-binding region, ATPase-like: (9e-08); KEGG: bld:BLi00556 RsbT, ev=3e-32, 55% identity YP_612135.1 PFAM: Sulfate transporter/antisigma-factor antagonist STAS: (3.6e-10); KEGG: mpa:MAP0378c hypothetical protein, ev=1e-24, 54% identity YP_612136.1 PFAM: Sulfate transporter/antisigma-factor antagonist STAS: (3.7e-11); KEGG: nfa:nfa32110 sigma activity regulator, ev=4e-31, 40% identity YP_612137.1 KEGG: rru:Rru_A0400 hypothetical protein, ev=2e-79, 38% identity YP_612138.1 PFAM: ETC complex I subunit conserved region: (1.3e-43); KEGG: sil:SPO0482 NADH-ubiquinone oxidoreductase family protein, ev=8e-46, 84% identity YP_612139.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_612140.1 KEGG: zmo:ZMO1485 dGTP triphosphohydrolase, ev=1e-125, 52% identity; TIGRFAM: Deoxyguanosinetriphosphate triphosphohydrolase: (4.8e-99); SMART: Metal-dependent phosphohydrolase, HD region: (1.5e-08) YP_612141.1 PFAM: FAD dependent oxidoreductase: (1.2e-31); KEGG: sil:SPO3552 oxidoreductase, FAD-binding, ev=1e-136, 69% identity YP_612142.1 PFAM: protein of unknown function DUF752: (2e-97); KEGG: sil:SPO3553 hypothetical protein, ev=7e-95, 73% identity YP_612143.1 PFAM: protein of unknown function DUF6, transmembrane: (6.6e-06); KEGG: sil:SPO3554 membrane protein, , ev=1e-118, 69% identity YP_612144.1 PFAM: Lytic transglycosylase, catalytic: (4.5e-15) Tetratricopeptide TPR_4: (0.051); KEGG: sil:SPO3555 transglycosylase, Slt family, ev=0.0, 61% identity YP_612145.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_612146.1 PFAM: sigma-70 region 2: (1.8e-16) sigma-70 region 4: (1.4e-06) Sigma-70, region 4 type 2: (2.5e-15); KEGG: rpa:RPA1116 RNA polymerase ECF-type sigma factor, ev=4e-88, 55% identity YP_612147.1 TIGRFAM: Alkylhydroperoxidase AhpD core: (6.2e-15); PFAM: Carboxymuconolactone decarboxylase: (4.3e-22); KEGG: rpb:RPB_1807 alkylhydroperoxidase, ev=7e-48, 66% identity YP_612148.1 PFAM: conserved hypothetical protein 698: (2.7e-71); KEGG: rsp:RSP_4010 conserved hypothetical protein 698, ev=1e-112, 65% identity YP_612149.1 KEGG: pub:SAR11_1347 hypothetical protein, ev=5e-25, 27% identity YP_612150.1 catalyzes the formation of acetyl phosphate and sulfite from 2-sulfoacetaldehyde; is active when grown on taurine as a sole carbon source YP_612151.1 PFAM: regulatory protein GntR, HTH: (4.6e-18) aminotransferase, class I and II: (2.9e-05); KEGG: sil:SPO3562 transcriptional regulator, ev=0.0, 70% identity YP_612152.1 PFAM: regulatory protein, ArsR: (9.8e-07); KEGG: sil:SPO3563 transcriptional regulator, ArsR family, ev=7e-26, 60% identity YP_612153.1 PFAM: permease: (4e-14); KEGG: sil:SPO3564 permease, , ev=1e-132, 72% identity YP_612154.1 PFAM: aminotransferase class-III: (4.8e-89); KEGG: sil:SPO0673 taurine--pyruvate aminotransferase, ev=0.0, 87% identity YP_612155.1 PFAM: protein of unknown function DUF849: (4.3e-13); KEGG: sil:SPO1400 hypothetical protein, ev=2e-58, 51% identity YP_612156.1 PFAM: aminotransferase class-III: (1.8e-106); KEGG: sil:SPO1401 aminotransferase, class III, ev=0.0, 75% identity YP_612157.1 PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase: (1.7e-121) aminotransferase, class I and II: (2.3e-05); KEGG: jan:Jann_2851 threonine aldolase, ev=1e-113, 63% identity YP_612158.1 KEGG: ret:RHE_CH00424 carboxyphosphonoenolpyruvate phosphonomutase protein, ev=5e-68, 51% identity YP_612159.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_612160.1 PFAM: conserved hypothetical protein 103: (2.4e-36); KEGG: sil:SPO3570 conserved hypothetical protein TIGR00103, ev=2e-45, 77% identity YP_612161.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_612162.1 PFAM: Dual specificity protein phosphatase: (9.1e-05); KEGG: sil:SPO3548 hypothetical protein, ev=3e-49, 59% identity YP_612163.1 KEGG: sil:SPO3547 hypothetical protein, ev=4e-21, 42% identity YP_612164.1 PFAM: metallophosphoesterase: (5.6e-14) 5'-Nucleotidase-like: (3.8e-21); KEGG: sil:SPO3542 2',3'-cyclic-nucleotide 2'-phosphodiesterase, , ev=1e-134, 44% identity YP_612165.1 PFAM: NUDIX hydrolase: (5e-25); KEGG: sil:SPO3541 hydrolase, NUDIX family, ev=1e-112, 62% identity YP_612166.1 KEGG: rsp:RSP_0707 hypothetical protein, ev=1e-16, 33% identity YP_612167.1 TIGRFAM: GGDEF domain: (3.9e-30); PFAM: GGDEF: (3.5e-34) EAL: (7.4e-110) MHYT: (6.7e-07); KEGG: jan:Jann_4149 diguanylate cyclase/phosphodiesterase, ev=0.0, 55% identity YP_612168.1 KEGG: nar:Saro_2759 transposase orfA IS5 family element, ev=5e-43, 79% identity YP_612169.1 PFAM: transposase, IS4: (2.1e-13); KEGG: sil:SPOA0134 ISSpo7, transposase, ev=6e-74, 70% identity YP_612170.1 KEGG: sil:SPO0670 DNA polymerase III, alpha subunit, , ev=0.0, 80% identity; TIGRFAM: DNA polymerase III, alpha subunit: (4.1e-128); PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type: (2e-11); SMART: Phosphoesterase PHP-like: (1e-07) YP_612171.1 KEGG: sil:SPO0671 hypothetical protein, ev=0.0, 68% identity YP_612172.1 KEGG: sil:SPO0672 hypothetical protein, ev=9e-57, 58% identity YP_612173.1 PFAM: HMG-I and HMG-Y, DNA-binding: (0.062) regulatory protein, TetR: (4.8e-11); KEGG: rpb:RPB_4262 transcriptional regulator, TetR family, ev=5e-24, 35% identity YP_612174.1 PFAM: metal-dependent phosphohydrolase, HD subdomain: (7.9e-08); KEGG: bja:blr7676 hypothetical protein, ev=2e-34, 36% identity YP_612175.1 KEGG: sil:SPOA0439 enoyl-(acyl-carrier-protein) reductase, ev=1e-129, 88% identity YP_612176.1 PFAM: beta-ketoacyl synthase: (1.6e-58); KEGG: sil:SPOA0440 3-oxoacyl-(acyl-carrier-protein) synthase, ev=0.0, 92% identity YP_612177.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_612178.1 PFAM: ferric-uptake regulator: (8.2e-15); KEGG: sil:SPOA0445 transcriptional regulator, Fur family, ev=5e-61, 81% identity YP_612179.1 KEGG: sil:SPOA0001 hypothetical protein, ev=1e-131, 73% identity YP_612180.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_612181.1 PFAM: OmpA/MotB: (1.3e-14); KEGG: sil:SPOA0004 OmpA family protein, ev=7e-59, 58% identity YP_612182.1 KEGG: sil:SPOA0005 lipoprotein, , ev=1e-22, 53% identity YP_612183.1 PFAM: PhoH-like protein: (8.6e-116); KEGG: sil:SPOA0006 PhoH family protein, ev=1e-141, 76% identity YP_612184.1 PFAM: GCN5-related N-acetyltransferase: (9.9e-16); KEGG: vvu:VV20941 histone acetyltransferase HPA2, ev=4e-25, 44% identity YP_612185.1 PFAM: protein of unknown function UPF0054: (7.6e-31); KEGG: sil:SPOA0008 conserved hypothetical protein TIGR00043, ev=2e-52, 62% identity YP_612186.1 PFAM: CBS: (1.3e-22) transporter-associated region: (1.4e-18); KEGG: sil:SPOA0009 hemolysin, , ev=1e-115, 70% identity YP_612187.1 TIGRFAM: apolipoprotein N-acyltransferase: (6e-83); PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase: (7e-09); KEGG: sil:SPOA0010 apolipoprotein N-acyltransferase, ev=1e-113, 48% identity YP_612188.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_612189.1 KEGG: sil:SPOA0013 hypothetical protein, ev=2e-50, 48% identity YP_612190.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_612191.1 PFAM: nitroreductase: (9.4e-38); KEGG: ccr:CC1449 nitroreductase family protein, ev=8e-63, 59% identity YP_612192.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_612193.1 PFAM: GCN5-related N-acetyltransferase: (1.4e-11); KEGG: bur:Bcep18194_C7224 GCN5-related N-acetyltransferase, ev=5e-19, 44% identity YP_612194.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_612195.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_612196.1 KEGG: ret:RHE_PF00158 hypothetical protein, ev=2e-72, 59% identity YP_612197.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_612198.1 KEGG: sil:SPO0805 hypothetical protein, ev=6e-37, 66% identity YP_612199.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_612200.1 PFAM: regulatory protein, LysR: (5e-17); KEGG: jan:Jann_2521 transcriptional regulator, LysR family, ev=3e-58, 45% identity YP_612201.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_612202.1 PFAM: helix-turn-helix, HxlR type: (9.1e-25); KEGG: ppr:PBPRB1657 hypothetical transcriptional regulator, ev=3e-36, 55% identity YP_612203.1 PFAM: NAD(P)H dehydrogenase (quinone): (7.1e-32); KEGG: dde:Dde_1618 flavodoxin-like fold domain protein, ev=1e-61, 57% identity YP_612204.1 PFAM: glutathione S-transferase-like: (2.6e-15); KEGG: ppr:PBPRB0681 glutathione S-transferase, ev=8e-52, 49% identity YP_612205.1 PFAM: DSBA oxidoreductase: (2.6e-37); KEGG: sil:SPO1390 thioredoxin domain protein, DsbA family, ev=3e-69, 59% identity YP_612206.1 PFAM: penicillin-binding protein, transpeptidase: (5.5e-13); KEGG: mca:MCA2220 beta-lactamase, ev=5e-24, 33% identity YP_612207.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (1.5e-13); KEGG: rba:RB3840 similar to dioxygenase superfamily, ev=9e-69, 73% identity YP_612208.1 PFAM: regulatory protein, LysR: (6.3e-19) LysR, substrate-binding: (6.5e-28); KEGG: vpa:VPA0175 transcriptional regulator, LysR family, ev=1e-52, 36% identity YP_612209.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_612211.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_612212.1 KEGG: jan:Jann_1985 hypothetical protein, ev=2e-32, 40% identity YP_612213.1 PFAM: major facilitator superfamily MFS_1: (7.2e-18); KEGG: jan:Jann_3597 major facilitator superfamily MFS_1, ev=7e-79, 44% identity YP_612214.1 PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase: (1.1e-168); KEGG: sil:SPO0813 L-lactate dehydrogenase, , ev=0.0, 87% identity YP_612216.1 PFAM: response regulator receiver: (2.7e-25) ATP-binding region, ATPase-like: (3.4e-35) histidine kinase A-like: (5.6e-25); KEGG: ccr:CC3219 sensor histidine kinase/response regulator, ev=5e-75, 39% identity YP_612217.2 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_612218.1 KEGG: sil:SPO0816 hypothetical protein, ev=6e-28, 40% identity YP_612219.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_612220.1 PFAM: Inosine/uridine-preferring nucleoside hydrolase: (1e-77); KEGG: hch:HCH_02314 inosine-uridine nucleoside N-ribohydrolase, ev=7e-60, 43% identity YP_612221.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_612222.1 KEGG: sil:SPO3516 transcription termination/antitermination factor NusG, ev=2e-85, 87% identity; TIGRFAM: transcription termination/antitermination factor NusG: (9.3e-79); PFAM: transcription antitermination protein NusG: (4.7e-41) KOW: (4.4e-09); SMART: NGN: (3.2e-36) KOW (Kyrpides, Ouzounis, Woese) motif: (2.8e-06) YP_612223.1 PFAM: glycosyl transferase, group 1: (1.6e-23); KEGG: jan:Jann_4272 glycosyl transferase, group 1, ev=4e-27, 31% identity YP_612224.1 binds directly to 23S ribosomal RNA YP_612225.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_612226.1 KEGG: sil:SPO3511 hypothetical protein, ev=3e-83, 52% identity YP_612227.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_612228.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_612229.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_612230.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_612231.1 KEGG: jan:Jann_0572 hypothetical protein, ev=3e-27, 34% identity YP_612232.1 PFAM: protein of unknown function DUF6, transmembrane: (1.8e-05); KEGG: sil:SPO3504 membrane protein, , ev=1e-78, 58% identity YP_612233.1 KEGG: sil:SPO3502 hypothetical protein, ev=3e-96, 64% identity YP_612234.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_612235.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_612236.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_612237.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_612238.1 KEGG: jan:Jann_3603 hypothetical protein, ev=1e-23, 45% identity YP_612240.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_612241.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_612242.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_612243.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_612245.1 KEGG: mlo:mll6838 hypothetical protein, ev=1e-06, 65% identity YP_612247.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_612248.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_612249.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_612250.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_612251.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_612253.1 SMART: extracellular solute-binding protein, family 3: (7.5e-06); KEGG: ret:RHE_CH03027 amino acid ABC transporter, substrate-binding protein, ev=2e-42, 41% identity YP_612254.1 TIGRFAM: conserved hypothetical protein: (2.2e-119); KEGG: sil:SPO0491 hypothetical protein, ev=4e-97, 81% identity YP_612255.1 PFAM: Succinylglutamate desuccinylase/aspartoacylase: (2.1e-71); KEGG: tcx:Tcr_2062 succinylglutamate desuccinylase/aspartoacylase, ev=2e-91, 53% identity YP_612256.1 KEGG: sil:SPO2022 hypothetical protein, ev=7e-42, 46% identity YP_612257.1 one of the stabilizing components for the large ribosomal subunit YP_612258.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_612259.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_612260.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_612261.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_612262.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_612263.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_612264.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_612265.1 binds 5S rRNA along with protein L5 and L25 YP_612266.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_612267.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_612268.1 PFAM: protein of unknown function DUF1127: (2.1e-05) YP_612269.1 late assembly protein YP_612270.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_612271.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_612272.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_612273.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_612274.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_612275.1 is a component of the macrolide binding site in the peptidyl transferase center YP_612277.1 TIGRFAM: alkylphosphonate utilization operon protein PhnA: (1.2e-46); PFAM: PhnA protein: (3.3e-33); KEGG: sil:SPO2122 alkylphosphonate utilization operon protein PhnA, ev=3e-44, 75% identity YP_612278.1 PFAM: NAD-dependent epimerase/dehydratase: (6.8e-21) 3-beta hydroxysteroid dehydrogenase/isomerase: (9.7e-07) dTDP-4-dehydrorhamnose reductase: (7e-05) Male sterility-like: (0.0029); KEGG: rba:RB3508 probable UDP-glucose 4-epimerase GalE2, ev=1e-100, 59% identity YP_612279.1 PFAM: protein of unknown function DUF161: (2.1e-17); KEGG: rsp:RSP_0447 hypothetical protein, ev=5e-38, 45% identity YP_612280.1 TIGRFAM: MATE efflux family protein: (4e-31); PFAM: multi antimicrobial extrusion protein MatE: (7.4e-20); KEGG: jan:Jann_3634 MATE efflux family protein, ev=1e-164, 66% identity YP_612281.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_612282.1 KEGG: sil:SPO0514 periplasmic serine protease, DO/DeqQ family, ev=1e-169, 65% identity; TIGRFAM: Peptidase S1C, Do: (2.5e-145); PFAM: peptidase S1 and S6, chymotrypsin/Hap: (3.1e-10); SMART: PDZ/DHR/GLGF: (0.00042) YP_612283.1 PFAM: AAA ATPase, central region: (8.4e-17) ATPase associated with various cellular activities, AAA_5: (0.00031); SMART: ATPase: (5.1e-14); KEGG: sil:SPO0515 ATPase, AAA family, ev=0.0, 82% identity YP_612284.1 PFAM: multicopper oxidase, type 1: (0.0033) multicopper oxidase, type 2: (5.9e-22) multicopper oxidase, type 3: (1.5e-47); KEGG: sil:SPOA0360 multicopper oxidase, , ev=1e-134, 52% identity YP_612285.1 PFAM: Camphor resistance CrcB protein: (2.7e-23); KEGG: rsp:RSP_1744 CrcB-like protein, ev=7e-35, 62% identity YP_612286.1 TIGRFAM: Pseudouridine synthase, RluD: (1.8e-70); PFAM: RNA-binding S4: (2.3e-06) pseudouridine synthase: (3e-41); KEGG: sil:SPO0516 ribosomal large subunit pseudouridine synthase C, ev=1e-159, 77% identity YP_612287.1 TIGRFAM: HAD-superfamily hydrolase subfamily IA, variant 3: (1.5e-05) HAD-superfamily hydrolase, subfamily IA, variant 1: (3e-06); PFAM: Haloacid dehalogenase-like hydrolase: (1.2e-27); KEGG: sil:SPO0517 HAD-superfamily hydrolase, subfamily IA, variant 1, ev=2e-71, 63% identity YP_612288.1 PFAM: ATP12 ATPase: (9.3e-53); KEGG: sil:SPO0518 hypothetical protein, ev=1e-87, 66% identity YP_612289.1 TIGRFAM: Lysine-arginine-ornithine-binding periplasmic protein: (1.7e-107); SMART: extracellular solute-binding protein, family 3: (1e-59); KEGG: sil:SPO0519 glutamate/glutamine/aspartate/asparagine ABC transporter, periplasmic substrate-binding protein, ev=1e-170, 84% identity YP_612290.1 TIGRFAM: Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine: (5.5e-07); PFAM: binding-protein-dependent transport systems inner membrane component: (1.3e-13); KEGG: sil:SPO0520 glutamate/glutamine/aspartate/asparagine ABC transporter, permease protein, ev=0.0, 77% identity YP_612291.1 TIGRFAM: Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine: (9.1e-09); PFAM: binding-protein-dependent transport systems inner membrane component: (1.7e-12); KEGG: sil:SPO0521 glutamate/glutamine/aspartate/asparagine ABC transporter, permease protein, ev=0.0, 73% identity YP_612292.1 PFAM: ABC transporter related: (2e-65); SMART: ATPase: (3.2e-16); KEGG: sil:SPO0522 glutamate/glutamine/aspartate/asparagine ABC transporter, ATP-binding protein, ev=1e-142, 96% identity YP_612293.1 PFAM: GCN5-related N-acetyltransferase: (3.5e-16) FR47-like: (0.00023); KEGG: rba:RB9493 probable acetyltransferase, ev=1e-27, 46% identity YP_612294.1 PFAM: Phosphoglycerate mutase: (1e-10); KEGG: sil:SPO0523 phosphoglycerate mutase family protein, ev=2e-38, 51% identity YP_612295.1 KEGG: sil:SPO0524 hypothetical protein, ev=3e-49, 49% identity YP_612296.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_612297.1 PFAM: NAD-dependent epimerase/dehydratase: (4.3e-05) short-chain dehydrogenase/reductase SDR: (4.7e-18); KEGG: sil:SPO0527 oxidoreductase, short chain dehydrogenase/reductase family, ev=1e-113, 84% identity YP_612298.1 PFAM: Propeptide, PepSY amd peptidase M4: (0.024) PepSY-associated TM helix: (0.003); KEGG: sil:SPO0528 membrane protein, , ev=0.0, 69% identity YP_612299.1 KEGG: sil:SPO0529 hypothetical protein, ev=5e-18, 40% identity YP_612300.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_612301.1 PFAM: MOSC: (2.2e-17); KEGG: jan:Jann_0636 MOSC, ev=4e-72, 53% identity YP_612302.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_612303.1 TIGRFAM: GGDEF domain: (4.3e-12); PFAM: GGDEF: (7.8e-09) EAL: (5e-80); KEGG: sil:SPO0533 diguanylate cyclase, , ev=1e-179, 61% identity YP_612304.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_612305.1 KEGG: jan:Jann_0639 hypothetical protein, ev=2e-56, 63% identity YP_612306.1 PFAM: protein of unknown function DUF37: (4e-26); KEGG: rsp:RSP_1061 hypothetical protein, ev=9e-31, 75% identity YP_612307.1 TIGRFAM: ribonuclease P protein component: (4.9e-12); PFAM: ribonuclease P protein: (7.3e-13); KEGG: sil:SPO0537 ribonuclease P protein component, ev=1e-36, 59% identity YP_612308.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_612309.1 KEGG: sil:SPO0539 membrane protein, , ev=2e-85, 68% identity YP_612310.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (3.2e-22) glucose-inhibited division protein A: (0.0015) pyridine nucleotide-disulphide oxidoreductase dimerisation region: (1.6e-33) HI0933-like protein: (0.0018) FAD dependent oxidoreductase: (0.00026); KEGG: sil:SPO0540 mercuric reductase, , ev=0.0, 68% identity YP_612311.1 PFAM: ATP-binding region, ATPase-like: (1e-30) histidine kinase, HAMP region: (0.00066) histidine kinase A-like: (2.3e-07); KEGG: sil:SPO0541 sensor histidine kinase, ev=1e-177, 71% identity YP_612314.1 PFAM: regulatory protein, TetR: (0.0011); KEGG: rba:RB13253 probable TetR-family transcriptional regulator, ev=3e-27, 34% identity YP_612315.1 PFAM: Carboxymuconolactone decarboxylase: (3.5e-05); KEGG: par:Psyc_1394 hypothetical protein, ev=3e-53, 53% identity YP_612316.1 PFAM: Redoxin: (4e-05); KEGG: mca:MCA2020 hypothetical protein, ev=3e-51, 56% identity YP_612317.1 PFAM: regulatory protein, LysR: (3.9e-16) LysR, substrate-binding: (7.6e-29); KEGG: sme:SMa2287 LysR-family transcriptional regulator, ev=5e-46, 41% identity YP_612318.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.12); KEGG: mlo:mll0236 probable binding protein component of ABC transporter, ev=1e-39, 30% identity YP_612319.1 PFAM: binding-protein-dependent transport systems inner membrane component: (0.0052); KEGG: sme:SMc01633 permease ABC transporter protein, ev=9e-30, 29% identity YP_612320.1 PFAM: binding-protein-dependent transport systems inner membrane component: (2.5e-06); KEGG: mlo:mll1739 permease protein of polyamine ABC transporter, ev=6e-38, 35% identity YP_612321.1 PFAM: ABC transporter related: (7.6e-62) TOBE: (9.3e-05) Transport-associated OB: (2.2e-12); SMART: ATPase: (8.6e-20); KEGG: mlo:mll8445 ABC-transporter ATP-binding protein, ev=2e-72, 41% identity YP_612322.1 PFAM: Amidase: (4e-65); KEGG: pst:PSPTO4204 amidase family protein, ev=2e-73, 41% identity YP_612323.1 PFAM: polysaccharide deacetylase: (5.1e-14); KEGG: sme:SMb21100 saccharide deacetylase, slightly similar to NodB protein, ev=4e-40, 35% identity YP_612324.1 KEGG: rsp:RSP_3746 hypothetical protein, ev=7e-37, 39% identity YP_612325.1 PFAM: NAD(P)H dehydrogenase (quinone): (7.2e-20); KEGG: ilo:IL1610 acyl carrier protein phosphodiesterase, ev=7e-46, 44% identity YP_612326.1 PFAM: regulatory protein, LysR: (1e-15) LysR, substrate-binding: (2.9e-26); KEGG: sme:SMa0179 transcriptional activator, ev=2e-40, 38% identity YP_612327.1 PFAM: regulatory protein, LysR: (1.6e-20) LysR, substrate-binding: (0.00013); KEGG: mlo:mlr1441 transcriptional activator protein AmpR, ev=8e-42, 42% identity YP_612328.1 PFAM: Taurine catabolism dioxygenase TauD/TfdA: (1.3e-32); KEGG: sil:SPO3380 gamma-butyrobetaine hydroxylase, , ev=1e-132, 63% identity YP_612329.1 KEGG: sil:SPO3381 hypothetical protein, ev=3e-81, 76% identity YP_612330.1 KEGG: ppu:PP2202 hypothetical protein, ev=1e-45, 63% identity YP_612331.1 PFAM: major facilitator superfamily MFS_1: (4.3e-24); KEGG: sme:SMa1641 probable NreB protein, ev=1e-153, 62% identity YP_612332.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_612333.1 TIGRFAM: NCS1 nucleoside transporter family: (3.3e-126); PFAM: permease for cytosine/purines, uracil, thiamine, allantoin: (2e-121); KEGG: rso:RSc1233 probable transporter transmembrane protein, ev=1e-152, 56% identity YP_612334.1 KEGG: sco:SCO5273 hypothetical protein, ev=2e-06, 26% identity YP_612335.1 PFAM: Peptidoglycan-binding LysM: (0.0037); KEGG: sil:SPO1062 LysM domain protein, ev=3e-38, 32% identity YP_612336.1 KEGG: sil:SPO1060 hypothetical protein, ev=2e-31, 33% identity YP_612337.1 PFAM: response regulator receiver: (1.3e-33) ATP-binding region, ATPase-like: (3.5e-39) histidine kinase A-like: (2e-27) CHASE: (3.1e-27) PAS fold-3: (4.2e-11) PAS fold-4: (2.1e-13) PAS fold: (2.8e-14); SMART: PAS: (6.5e-09) PAC motif: (3.9e-10); KEGG: sil:SPO0094 sensory box sensor histidine kinase/response regulator, ev=1e-146, 48% identity YP_612338.1 with HmuTU is involved in the transport of hemin YP_612339.1 PFAM: transport system permease protein: (3.1e-108); KEGG: jan:Jann_2135 transport system permease protein, ev=1e-122, 66% identity YP_612340.1 PFAM: periplasmic binding protein: (1.4e-24); KEGG: jan:Jann_2134 periplasmic binding protein, ev=3e-79, 58% identity YP_612341.1 PFAM: Haemin-degrading: (1.8e-106); KEGG: jan:Jann_2133 Haemin-degrading, ev=2e-99, 54% identity YP_612342.1 PFAM: TonB-dependent receptor: (4.9e-14) TonB-dependent receptor, plug: (1.8e-18); KEGG: jan:Jann_2132 TonB-dependent haem/haemoglobin receptor, ev=4e-66, 31% identity YP_612343.1 KEGG: jan:Jann_2131 hypothetical protein, ev=2e-23, 47% identity YP_612344.1 PFAM: MotA/TolQ/ExbB proton channel: (8.3e-16); KEGG: jan:Jann_2130 MotA/TolQ/ExbB proton channel, ev=5e-43, 45% identity YP_612345.1 KEGG: jan:Jann_2129 biopolymer transport protein ExbD/TolR, ev=2e-25, 51% identity YP_612346.1 KEGG: jan:Jann_2128 hypothetical protein, ev=1e-26, 50% identity YP_612347.1 TIGRFAM: TonB-like: (7e-10); KEGG: jan:Jann_2127 TonB-like, ev=3e-40, 37% identity YP_612348.1 KEGG: sil:SPOA0416 hypothetical protein, ev=5e-90, 66% identity YP_612349.1 PFAM: regulatory protein, LysR: (1e-18) LysR, substrate-binding: (2.1e-37); KEGG: jan:Jann_1407 transcriptional regulator, LysR family, ev=1e-113, 66% identity YP_612350.1 PFAM: FAD dependent oxidoreductase: (2.1e-63); KEGG: jan:Jann_1410 D-amino-acid dehydrogenase, ev=1e-151, 61% identity YP_612351.1 PFAM: TRAP dicarboxylate transporter- DctP subunit: (1.7e-22); KEGG: sil:SPO3665 bacterial extracellular solute-binding protein, family 7, ev=5e-97, 54% identity YP_612352.1 KEGG: sil:SPO3664 hypothetical protein, ev=8e-25, 38% identity YP_612353.1 TIGRFAM: TRAP dicarboxylate transporter- DctM subunit: (4.2e-116); PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (2.7e-66); KEGG: sil:SPO3663 TRAP dicarboxylate family transporter, DctM subunit, ev=0.0, 73% identity YP_612354.1 PFAM: histidine kinase, HAMP region: (1.5e-08) chemotaxis sensory transducer: (1.2e-84); KEGG: sme:SMc01104 probable chemoreceptor (methyl-accepting chemotaxis) transmembrane protein, ev=3e-93, 47% identity YP_612355.1 PFAM: Enoyl-CoA hydratase/isomerase: (4.3e-58) 3-hydroxyacyl-CoA dehydrogenase-like: (5.1e-06) 3-hydroxyacyl-CoA dehydrogenase, NAD-binding: (1e-76); KEGG: sil:SPO0772 enoyl-CoA hydratase/isomerase/3-hydroxyacyl-CoA dehydrogenase, ev=0.0, 63% identity YP_612356.1 PFAM: Thiolase: (2.8e-72); KEGG: sil:SPO0773 acetyl-CoA acyltransferase/thiolase family protein, ev=1e-157, 72% identity YP_612357.1 SMART: regulatory proteins, IclR: (6.6e-20); KEGG: mag:amb2598 transcriptional regulator, ev=5e-35, 36% identity YP_612358.1 PFAM: ROK: (0.00052) Glucokinase: (3.4e-65); KEGG: sme:SMc02835 probable glucokinase transmembrane protein, ev=2e-42, 37% identity YP_612359.1 KEGG: ccr:CC3356 hypothetical protein, ev=8e-62, 53% identity YP_612360.1 PFAM: regulatory protein GntR, HTH: (3.2e-07) GntR-like: (2.2e-23); KEGG: psb:Psyr_2675 regulatory protein, GntR:bacterial regulatory protein, GntR, ev=9e-26, 36% identity YP_612361.1 PFAM: protein of unknown function DUF81: (4.8e-33); KEGG: rru:Rru_A1348 protein of unknown function DUF81, ev=1e-50, 41% identity YP_612362.1 PFAM: ROK: (2.8e-06) Helix-turn-helix, type 11: (0.0016); KEGG: ret:RHE_CH00464 sugar transcriptional regulator protein, ROK family, ev=1e-105, 45% identity YP_612363.1 PFAM: periplasmic binding protein/LacI transcriptional regulator: (4.9e-08); KEGG: jan:Jann_1373 periplasmic binding protein/LacI transcriptional regulator, ev=1e-146, 76% identity YP_612364.1 PFAM: inner-membrane translocator: (1.8e-62); KEGG: jan:Jann_1374 inner-membrane translocator, ev=1e-150, 77% identity YP_612365.1 PFAM: ABC transporter related: (1.7e-44); SMART: ATPase: (2.3e-18); KEGG: jan:Jann_1375 ABC transporter related, ev=1e-116, 82% identity YP_612366.1 KEGG: sme:SMc02167 hypothetical protein, ev=5e-46, 47% identity YP_612367.1 PFAM: protein of unknown function DUF1498: (1.3e-127); KEGG: mlo:mlr8329 hypothetical protein, ev=7e-84, 67% identity YP_612368.1 PFAM: NAD-dependent epimerase/dehydratase: (1.7e-08); KEGG: sil:SPO2846 hypothetical protein, ev=2e-53, 42% identity YP_612369.1 PFAM: glutathione-dependent formaldehyde-activating, GFA: (5.6e-07); KEGG: dde:Dde_3339 hypothetical protein, ev=1e-25, 41% identity YP_612370.1 KEGG: sil:SPO3031 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase, ev=2e-84, 77% identity; TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase: (8.5e-91); PFAM: KDPG and KHG aldolase: (1.1e-81) YP_612371.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_612372.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_612373.1 PFAM: phosphoglucose isomerase (PGI): (4.9e-230); KEGG: mlo:mlr5411 glucose-6-phosphate isomerase, ev=0.0, 64% identity YP_612375.1 TIGRFAM: urease accessory protein UreG: (1.9e-114); PFAM: cobalamin synthesis protein, P47K: (5.1e-68); KEGG: sil:SPO1717 urease accessory protein UreG, ev=1e-88, 81% identity YP_612376.1 PFAM: Urease accessory protein UreF: (4.6e-07); KEGG: sil:SPO1716 urease accessory protein UreF, ev=3e-53, 50% identity YP_612377.1 involved in the assembly of the urease metallocenter; possible nickel donor YP_612380.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_612381.1 KEGG: sil:SPO1713 urease, beta subunit, ev=2e-41, 80% identity; TIGRFAM: urease, beta subunit: (1.1e-42); PFAM: Urease, beta subunit: (2e-63) YP_612382.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_612383.1 PFAM: Urease accessory protein UreD: (2.5e-39); KEGG: sil:SPO1711 urease accessory protein UreD, ev=1e-58, 51% identity YP_612384.1 PFAM: L-carnitine dehydratase/bile acid-inducible protein F: (2.4e-82); KEGG: sil:SPO0820 CAIB/BAIF family protein, ev=1e-141, 64% identity YP_612385.1 KEGG: mlo:mll6996 hypothetical protein, ev=8e-40, 37% identity YP_612386.1 PFAM: peptidase S15: (5.3e-82) X-Pro dipeptidyl-peptidase-like: (1.2e-54); KEGG: mlo:mll5128 similar to glutaryl 7-ACA acylase, ev=1e-159, 44% identity YP_612388.1 KEGG: sil:SPO1805 hypothetical protein, ev=6e-59, 70% identity YP_612389.1 KEGG: sil:SPO1804 hypothetical protein, ev=8e-78, 64% identity YP_612390.1 KEGG: sil:SPO1803 Mrp/NBP35 family protein, ev=1e-155, 78% identity YP_612391.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding: (3.8e-07); KEGG: sil:SPO1800 iron-sulfur cluster-binding protein, ev=0.0, 60% identity YP_612392.1 KEGG: mag:amb2667 molybdopterin-guanine dinucleotide biosynthesis protein A, ev=6e-18, 35% identity YP_612393.1 KEGG: sil:SPO1799 hypothetical protein, ev=4e-48, 53% identity YP_612394.1 PFAM: cytoplasmic chaperone TorD: (9.9e-24); KEGG: sil:SPO1798 chaperone, TorD family, ev=3e-81, 73% identity YP_612395.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.0019); KEGG: sil:SPO1797 twin-arginine translocation pathway signal sequence domain protein, ev=3e-13, 65% identity YP_612396.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.019); PFAM: molybdopterin oxidoreductase: (1.4e-55) molydopterin dinucleotide-binding region: (1.3e-26) molybdopterin oxidoreductase Fe4S4 region: (1.3e-15); KEGG: sil:SPO1796 formate dehydrogenase, alpha subunit, , ev=0.0, 91% identity YP_612397.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding: (6.5e-07); KEGG: sil:SPO1795 formate dehydrogenase, iron-sulfur subunit, , ev=1e-115, 95% identity YP_612398.1 TIGRFAM: Formate dehydrogenase, gamma subunit: (1.6e-36); KEGG: sil:SPO1794 formate dehydrogenase, gamma subunit, ev=1e-131, 59% identity YP_612399.1 PFAM: WD-40 repeat: (0.00053) cytochrome c, class I: (7e-05); KEGG: sil:SPO1793 WD domain/cytochrome c family protein, ev=1e-125, 56% identity YP_612400.1 PFAM: response regulator receiver: (9.2e-27) sigma-54 factor, interaction region: (5.2e-95) helix-turn-helix, Fis-type: (1.8e-07) ATPase associated with various cellular activities, AAA_5: (0.00012); SMART: ATPase: (2.2e-10); KEGG: eba:ebA2951 sigma-54 dependent response regulator, ev=1e-116, 49% identity YP_612401.1 PFAM: ATP-binding region, ATPase-like: (8.8e-32) histidine kinase, HAMP region: (1.9e-14) histidine kinase A-like: (2e-12); KEGG: dar:Daro_1828 ATP-binding region, ATPase-like:histidine kinase, HAMP region:histidine kinase A, N-terminal, ev=1e-154, 45% identity YP_612402.1 PFAM: short-chain dehydrogenase/reductase SDR: (5.4e-06); KEGG: nar:Saro_2960 short-chain dehydrogenase/reductase SDR, ev=2e-57, 51% identity YP_612403.1 PFAM: NAD-dependent epimerase/dehydratase: (0.0033) short-chain dehydrogenase/reductase SDR: (1.4e-15); KEGG: sil:SPO1480 oxidoreductase, short-chain dehydrogenase/reductase family, ev=2e-72, 57% identity YP_612404.1 KEGG: sil:SPO1486 hypothetical protein, ev=5e-59, 59% identity YP_612405.1 KEGG: sil:SPO1485 sodium:galactoside symporter family protein, ev=1e-118, 56% identity YP_612406.1 KEGG: sil:SPO1484 hypothetical protein, ev=6e-23, 35% identity YP_612407.1 PFAM: Cyclopropane-fatty-acyl-phospholipid synthase: (5e-80) Methyltransferase type 11: (2.4e-09) Methyltransferase type 12: (9.5e-12); KEGG: sil:SPO1483 cyclopropane-fatty-acyl-phospholipid synthase, , ev=1e-135, 60% identity YP_612408.1 PFAM: protein of unknown function DUF1365: (2.3e-29); KEGG: rsp:RSP_1090 cyclopropane/cyclopropene fatty acid synthesis protein, ev=3e-74, 57% identity YP_612409.1 PFAM: amine oxidase: (0.00038) FAD dependent oxidoreductase: (3e-06); KEGG: sil:SPO1482 hypothetical protein, ev=1e-151, 60% identity YP_612410.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_612411.1 TIGRFAM: Anti-sigma factor ChrR , : (6.8e-79); KEGG: sil:SPO1479 transcriptional activator, , ev=1e-71, 61% identity YP_612412.1 KEGG: sil:SPO0701 glyceraldehyde-3-phosphate dehydrogenase, type I, ev=1e-149, 79% identity; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I: (3.1e-179); PFAM: glyceraldehyde 3-phosphate dehydrogenase: (1.8e-82) YP_612413.1 PFAM: alpha amylase, catalytic region: (8.7e-07); SMART: Alpha amylase, catalytic subdomain: (3.3e-09); KEGG: hch:HCH_00269 glycosidase, ev=1e-160, 48% identity YP_612414.1 KEGG: hch:HCH_03746 hypothetical protein, ev=4e-24, 62% identity YP_612415.1 KEGG: hch:HCH_00270 glycosyltransferase involved in cell wall biogenesis, ev=1e-140, 58% identity YP_612416.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate YP_612417.1 PFAM: BCCT transporter: (1.3e-131); KEGG: jan:Jann_1593 BCCT transporter, ev=0.0, 65% identity YP_612418.1 PFAM: fumarylacetoacetate (FAA) hydrolase: (9.3e-59); KEGG: rsp:RSP_1562 fumarylacetoacetate hydrolase family protein, ev=4e-91, 71% identity YP_612419.1 KEGG: jan:Jann_2999 hypothetical protein, ev=1e-134, 53% identity YP_612421.1 PFAM: Mannitol dehydrogenase-like: (2.5e-85) Mannitol dehydrogenase rossman-like: (1.7e-77); KEGG: jan:Jann_2907 mannitol dehydrogenase-like, ev=0.0, 68% identity YP_612422.1 Converts D-sorbitol to L-sorbose YP_612423.1 PFAM: ABC transporter related: (1.2e-61) TOBE: (0.00066) Transport-associated OB: (3.2e-09); SMART: ATPase: (4.3e-17); KEGG: jan:Jann_2905 ABC transporter related, ev=1e-149, 79% identity YP_612424.1 PFAM: binding-protein-dependent transport systems inner membrane component: (4.7e-12); KEGG: jan:Jann_2904 binding-protein-dependent transport systems inner membrane component, ev=1e-131, 84% identity YP_612425.1 PFAM: binding-protein-dependent transport systems inner membrane component: (9.7e-11); KEGG: jan:Jann_2903 binding-protein-dependent transport systems inner membrane component, ev=1e-132, 79% identity YP_612426.1 PFAM: extracellular solute-binding protein, family 1: (5e-49); KEGG: rsp:RSP_0091 ABC sorbitol/mannitol transporter, periplasmic binding protein, ev=0.0, 72% identity YP_612427.1 PFAM: periplasmic binding protein/LacI transcriptional regulator: (2.6e-05); SMART: regulatory protein, LacI: (6.1e-14); KEGG: jan:Jann_2901 transcriptional regulator, LacI family, ev=1e-122, 62% identity YP_612428.1 PFAM: histidine kinase, HAMP region: (7.9e-16) chemotaxis sensory transducer: (4.5e-59); KEGG: ret:RHE_CH03477 probable methyl-accepting chemotaxis protein, ev=5e-84, 32% identity YP_612429.1 PFAM: FAD dependent oxidoreductase: (1.4e-87) glycine cleavage T protein (aminomethyl transferase): (6.4e-60); KEGG: sme:SMb21534 dehydrogenase protein, ev=0.0, 47% identity YP_612430.1 PFAM: regulatory protein, TetR: (6.3e-11); KEGG: mlo:mll3671 transcriptional regulator, ev=5e-33, 37% identity YP_612431.1 PFAM: PaaX-like: (1.1e-10); KEGG: sil:SPO0734 PaaX domain protein, ev=2e-66, 50% identity YP_612432.1 catalyzes the ring cleavage reaction in phenylacetate degradation and the formation of 3-hydroxyacyl-CoA from crotonyl-CoA YP_612433.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_612434.1 TIGRFAM: Phenylacetic acid degradation-related protein: (1e-24) Phenylacetic acid degradation protein PaaD: (1.7e-58); PFAM: thioesterase superfamily: (1.8e-18); KEGG: sil:SPO0741 phenylacetic acid degradation protein PaaD, ev=1e-59, 78% identity YP_612435.1 TIGRFAM: Phenylacetate-CoA ligase: (3.5e-299); KEGG: sil:SPO0742 phenylacetate-CoA ligase, ev=0.0, 83% identity YP_612436.1 PFAM: regulatory protein, TetR: (1.7e-18); KEGG: sil:SPO0743 transcriptional regulator, TetR family, ev=3e-69, 61% identity YP_612437.1 PFAM: 17 kDa surface antigen: (3e-05); KEGG: vpa:VPA0312 hypothetical protein, ev=8e-06, 59% identity YP_612438.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_612439.1 PFAM: Rhomboid-like protein: (2.3e-06); KEGG: sil:SPO0393 rhomboid family protein, ev=3e-79, 62% identity YP_612440.1 TIGRFAM: integral membrane protein MviN: (6.6e-117); PFAM: virulence factor MVIN-like: (3e-113); KEGG: sil:SPO0396 integral membrane protein MviN, ev=0.0, 74% identity YP_612441.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_612442.1 PFAM: Extracellular ligand-binding receptor: (4.4e-05); KEGG: sil:SPO0398 hypothetical protein, ev=1e-157, 72% identity YP_612443.1 TIGRFAM: Protein of unknown function UPF0011: (1.4e-60); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase: (6.4e-35); KEGG: sil:SPO0399 tetrapyrrole methylase family protein, ev=1e-106, 70% identity YP_612444.1 PFAM: protein of unknown function UPF0102: (3.6e-07); KEGG: sil:SPO0400 endonuclease, ev=3e-26, 52% identity YP_612445.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_612446.1 PFAM: Alpha/beta hydrolase fold-3: (3e-51); KEGG: bpm:BURPS1710b_0827 esterase, , ev=2e-46, 38% identity YP_612447.1 KEGG: sil:SPO0402 competence protein ComM, ev=0.0, 73% identity; TIGRFAM: Mg chelatase-related protein: (1.4e-184); PFAM: magnesium chelatase, ChlI subunit: (3.3e-141); SMART: ATPase: (5.9e-09) YP_612448.1 KEGG: sil:SPO0403 hypothetical protein, ev=2e-83, 66% identity YP_612449.1 PFAM: Phosphoglycerate mutase: (5.3e-24); KEGG: sil:SPO0404 phosphoglycerate mutase family protein, ev=2e-68, 63% identity YP_612450.1 PFAM: cobalbumin biosynthesis enzyme: (7e-53); KEGG: sil:SPO0405 cobinamide kinase/cobinamide phosphate guanyltransferase, ev=5e-60, 68% identity YP_612451.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma-32 is responsible for the expression of heat shock promoters; there are paralogs in Rhizobium and Sinorhizobium; the proteins in this cluster act as secondary heat shock sigma factors; the Rhizobium sigma-32 factor may also be involved in exopolysaccharide production YP_612452.1 KEGG: sil:SPO0407 hypothetical protein, ev=2e-69, 52% identity YP_612453.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_612455.1 PFAM: CheB methylesterase: (1.8e-14) MCP methyltransferase, CheR-type: (2.1e-60); KEGG: jan:Jann_2564 MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor, ev=0.0, 51% identity YP_612456.1 KEGG: reu:Reut_A2749 DeoxyUTP pyrophosphatase subfamily 1, ev=2e-52, 61% identity; TIGRFAM: deoxyuridine 5'-triphosphate nucleotidohydrolase (dut): (1.8e-42); PFAM: deoxyUTP pyrophosphatase: (4.7e-31) YP_612457.1 PFAM: UBA/THIF-type NAD/FAD binding fold: (7.8e-62) MoeZ/MoeB: (7.5e-39); KEGG: sil:SPO0410 molybdopterin biosynthesis protein MoeB, , ev=1e-133, 70% identity YP_612458.1 PFAM: extracellular solute-binding protein, family 3: (5.2e-58); SMART: Ionotropic glutamate receptor: (4.1e-06); KEGG: sme:SMc03864 amino acid-binding periplasmic (signal peptide) ABC transporter protein, ev=1e-98, 67% identity YP_612459.1 TIGRFAM: Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine: (1.4e-12); PFAM: binding-protein-dependent transport systems inner membrane component: (1.3e-29); KEGG: jan:Jann_0911 amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine, ev=9e-95, 68% identity YP_612460.1 PFAM: peptidase M3A and M3B, thimet/oligopeptidase F: (8.4e-115); KEGG: sil:SPO0414 peptidyl-dipeptidase, , ev=0.0, 79% identity YP_612461.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding: (5e-48); KEGG: sil:SPO0415 D-isomer specific 2-hydroxyacid dehydrogenase family protein, ev=1e-117, 65% identity YP_612462.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (1.6e-10); KEGG: atc:AGR_pAT_700 probable ring-cleaving dioxygenase PA0817, ev=2e-55, 70% identity YP_612463.1 PFAM: regulatory protein, LysR: (1.6e-15) LysR, substrate-binding: (1.2e-17); KEGG: bpa:BPP1605 probable LysR-family transcriptional regulator, ev=4e-36, 38% identity YP_612464.1 TIGRFAM: Rod shape-determining protein RodA: (6.5e-183); PFAM: cell cycle protein: (4.8e-107); KEGG: sil:SPO0416 rod shape-determining protein MreD, ev=0.0, 82% identity YP_612465.1 PFAM: penicillin-binding protein, transpeptidase: (6.7e-70) Penicillin-binding protein, dimerisation domain: (5.1e-35); KEGG: sil:SPO0417 penicillin-binding protein 2, ev=0.0, 76% identity YP_612466.1 KEGG: sil:SPO0418 rod shape-determining protein MreD, ev=2e-56, 60% identity YP_612467.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_612468.1 functions in MreBCD complex in some organisms YP_612469.1 KEGG: jan:Jann_0595 hypothetical protein, ev=1e-44, 47% identity YP_612470.1 PFAM: protein of unknown function DUF519: (3.8e-54); KEGG: sil:SPO0421 hypothetical protein, ev=1e-103, 70% identity YP_612471.1 PFAM: histidine kinase, HAMP region: (3e-12) chemotaxis sensory transducer: (6.9e-68) Cache, type 2: (6.7e-24); KEGG: sme:SMc04227 probable chemoreceptor (methyl-accepting chemotaxis) transmembrane protein, ev=1e-103, 38% identity YP_612472.1 KEGG: sil:SPOA0315 isocitrate dehydrogenase, NADP-dependent, ev=0.0, 83% identity; TIGRFAM: isocitrate dehydrogenase, NADP-dependent: (0); PFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type: (0) YP_612473.1 PFAM: glycosyl transferase, group 1: (2.7e-05); KEGG: fra:Francci3_3362 glycosyl transferase, group 1, ev=7e-12, 29% identity YP_612474.1 PFAM: protein of unknown function DUF1058: (2.6e-16); KEGG: sil:SPO0631 hypothetical protein, ev=1e-58, 65% identity YP_612475.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region: (8.5e-38) D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding: (2.4e-81); KEGG: sil:SPO0632 D-isomer specific 2-hydroxyacid dehydrogenase family protein, ev=1e-162, 85% identity YP_612476.1 KEGG: lma:LmjF35.0550 proteophosphoglycan ppg1, ev=4e-07, 26% identity YP_612477.1 PFAM: gamma-glutamyltranspeptidase: (7.5e-127); KEGG: sil:SPO0633 gamma-glutamyltranspeptidase, ev=0.0, 76% identity YP_612478.1 PFAM: FAD linked oxidase-like: (9.6e-76); KEGG: sil:SPO0634 oxidoreductase, FAD-binding, ev=0.0, 72% identity YP_612480.1 PFAM: glutathione-dependent formaldehyde-activating, GFA: (2.7e-11); KEGG: atc:AGR_C_2344 hypothetical protein SPAC29B12.13, ev=3e-19, 37% identity YP_612481.1 PFAM: FAD dependent oxidoreductase: (4e-80) glycine cleavage T protein (aminomethyl transferase): (1e-45); KEGG: sil:SPO0635 aminomethyl transferase family protein, ev=0.0, 92% identity YP_612482.1 KEGG: vvy:VV2684 GGDEF family protein, ev=5e-08, 20% identity YP_612483.1 PFAM: Calcium-binding EF-hand: (0.0024); KEGG: rpb:RPB_3148 hypothetical protein, ev=4e-13, 30% identity YP_612484.1 PFAM: protein of unknown function DUF938: (6.9e-36) Methyltransferase type 11: (3.7e-07) Methyltransferase type 12: (9.1e-06); KEGG: sil:SPO0641 hypothetical protein, ev=2e-53, 52% identity YP_612485.1 PFAM: FAD dependent oxidoreductase: (5.5e-58); KEGG: sil:SPO0642 oxidoreductase, FAD-binding, ev=1e-119, 60% identity YP_612486.1 PFAM: aldo/keto reductase: (1.7e-59); KEGG: sil:SPO0643 oxidoreductase, aldo/keto reductase family, ev=1e-115, 66% identity YP_612487.1 PFAM: CDP-alcohol phosphatidyltransferase: (3.6e-10); KEGG: rsp:RSP_0198 phosphatidylglycerophosphate synthase, ev=2e-64, 64% identity YP_612488.1 PFAM: basic membrane lipoprotein: (1.2e-47); KEGG: sil:SPO0648 bmp family protein, ev=0.0, 88% identity YP_612489.1 PFAM: inner-membrane translocator: (5.7e-44); KEGG: sil:SPO0649 sugar ABC transporter, permease protein, ev=1e-150, 88% identity YP_612490.1 PFAM: inner-membrane translocator: (3e-51); KEGG: sil:SPO0650 sugar ABC transporter, permease protein, ev=0.0, 87% identity YP_612491.1 PFAM: ABC transporter related: (2.2e-09); SMART: ATPase: (5e-11); KEGG: sil:SPO0651 sugar ABC transporter, ATP-binding protein, ev=0.0, 86% identity YP_612492.1 PFAM: protein of unknown function DUF182: (8.2e-12); KEGG: sil:SPO0652 xanthine dehydrogenase accessory factor, ev=1e-107, 61% identity YP_612493.1 PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead: (8.9e-38) aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding: (3.2e-203); KEGG: sil:SPO0653 xanthine dehydrogenase, B subunit, ev=0.0, 77% identity YP_612494.1 PFAM: ferredoxin: (1.3e-09) molybdopterin dehydrogenase, FAD-binding: (2.5e-50) [2Fe-2S]-binding: (7e-37) CO dehydrogenase flavoprotein-like: (2.1e-26); KEGG: sil:SPO0654 xanthine dehydrogenase, A subunit, ev=0.0, 71% identity YP_612495.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_612496.1 KEGG: sme:SMb20463 hypothetical protein, ev=4e-08, 27% identity YP_612497.1 KEGG: sil:SPO0665 SlyX protein, , ev=9e-18, 65% identity YP_612498.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_612499.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_612500.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_612501.1 PFAM: Uncharacterised conserved protein UCP032025: (1.4e-56); KEGG: sil:SPO3193 hypothetical protein, ev=8e-58, 69% identity YP_612502.1 TIGRFAM: conserved hypothetical protein: (7.9e-10); KEGG: sil:SPO3623 hypothetical protein, ev=1e-41, 71% identity YP_612503.1 PFAM: protein of unknown function DUF45: (4.9e-65); KEGG: sil:SPO3622 hypothetical protein, ev=7e-69, 59% identity YP_612504.1 PFAM: regulatory protein GntR, HTH: (6.2e-11) GntR-like: (6.2e-05); KEGG: sil:SPO3621 transcriptional regulator, GntR family, ev=4e-99, 90% identity YP_612505.1 KEGG: vch:VC2649 serine acetyltransferase, ev=5e-34, 38% identity YP_612506.1 KEGG: psp:PSPPH_1713 hypothetical protein, ev=1e-36, 34% identity YP_612507.1 KEGG: cvi:CV1884 hippurate hydrolase, ev=1e-103, 51% identity; TIGRFAM: Peptidase M20D, amidohydrolase: (1.2e-119); PFAM: peptidase M20: (3.5e-59) peptidase dimerisation: (2.2e-05) YP_612508.1 PFAM: regulatory protein, LysR: (6.6e-19) LysR, substrate-binding: (2.6e-37); KEGG: bbr:BB0654 LysR-family transcriptional regulator, ev=1e-37, 34% identity YP_612509.1 PFAM: 6-phosphogluconate dehydrogenase, NAD-binding: (9.9e-48) 3-hydroxyacyl-CoA dehydrogenase, NAD-binding: (0.00031); KEGG: psb:Psyr_3525 3-hydroxyisobutyrate dehydrogenase, ev=2e-61, 44% identity YP_612510.1 PFAM: aldehyde dehydrogenase: (2.5e-214); KEGG: psb:Psyr_3524 aldehyde dehydrogenase (NAD+), ev=1e-156, 55% identity YP_612511.1 KEGG: cvi:CV1885 hypothetical protein, ev=2e-73, 52% identity YP_612512.1 KEGG: dde:Dde_3032 hypothetical protein, ev=3e-24, 43% identity YP_612513.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_612514.1 Catalyzes the rate-limiting step in dNTP synthesis YP_612515.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_612516.1 TIGRFAM: Glutaredoxin-like protein NrdH: (9.8e-37); PFAM: glutaredoxin: (8.8e-16); KEGG: bmb:BruAb2_0867 NrdH, glutaredoxin-like protein NrdH, ev=3e-25, 68% identity YP_612517.1 PFAM: glutathione-dependent formaldehyde-activating, GFA: (1.7e-13); KEGG: pfo:Pfl_2171 glutathione-dependent formaldehyde-activating, GFA, ev=2e-40, 58% identity YP_612518.1 PFAM: Bile acid:sodium symporter: (3.9e-39); KEGG: rsp:RSP_3126 arsenite efflux pump, ACR3 family, ev=1e-137, 74% identity YP_612519.1 PFAM: major facilitator superfamily MFS_1: (0.00025); KEGG: sil:SPO3879 membrane protein, , ev=0.0, 83% identity YP_612520.1 KEGG: sil:SPO3878 glyceraldehyde-3-phosphate dehydrogenase, type I, ev=1e-166, 87% identity; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I: (5.9e-160); PFAM: glyceraldehyde 3-phosphate dehydrogenase: (2e-61) YP_612521.1 PFAM: low molecular weight phosphotyrosine protein phosphatase: (2.4e-35) regulatory protein, ArsR: (0.00029); KEGG: sil:SPO3877 transcriptional regulator/arsenate reductase, ev=1e-124, 77% identity YP_612522.1 PFAM: peptidase S1 and S6, chymotrypsin/Hap: (8.2e-07); KEGG: sil:SPO3482 trypsin domain protein, ev=5e-43, 44% identity YP_612523.1 TIGRFAM: Type I secretion membrane fusion protein, HlyD: (3.3e-94); PFAM: secretion protein HlyD: (9.8e-15); KEGG: bja:blr5469 probable HlyD family secretion protein, ev=1e-67, 37% identity YP_612524.1 PFAM: ABC transporter, transmembrane region: (5.1e-08) ABC transporter related: (4.1e-55); SMART: ATPase: (5.2e-20); KEGG: pae:PA1876 probable ATP-binding/permease fusion ABC transporter, ev=1e-132, 39% identity YP_612525.1 PFAM: outer membrane efflux protein: (4.7e-06); KEGG: pae:PA1875 hypothetical protein, ev=3e-13, 21% identity YP_612526.1 KEGG: ecs:ECs0541 hypothetical protein, ev=1e-61, 27% identity YP_612527.1 PFAM: PrkA serine kinase: (8.1e-165) PrkA AAA: (7.4e-250); KEGG: mag:amb2153 Ser protein kinase, ev=0.0, 75% identity YP_612528.1 KEGG: cvi:CV1790 hypothetical protein, ev=2e-26, 52% identity YP_612529.1 PFAM: protein of unknown function DUF444: (1e-58); KEGG: mlo:mll9637 hypothetical protein, ev=3e-85, 54% identity YP_612530.1 PFAM: SpoVR: (5.1e-261); KEGG: sme:SMc01265 hypothetical protein, ev=0.0, 63% identity YP_612531.1 PFAM: Alcohol dehydrogenase, zinc-binding: (3.4e-30) Alcohol dehydrogenase GroES-like: (5.4e-35); KEGG: jan:Jann_0044 alcohol dehydrogenase GroES-like, ev=0.0, 87% identity YP_612532.1 TIGRFAM: Cu(I)-responsive transcriptional regulator: (2.3e-57); PFAM: regulatory protein, MerR: (9.4e-12); KEGG: sil:SPO0793 Cu(I)-responsive transcriptional regulator, ev=2e-50, 74% identity YP_612533.1 KEGG: rpb:RPB_0861 TPR repeat protein, ev=6e-19, 31% identity YP_612534.1 KEGG: rsp:RSP_1299 binding domain, ev=3e-16, 27% identity YP_612535.1 PFAM: Phosphoglycerate mutase: (1.3e-29); KEGG: rru:Rru_A2210 phosphoglycerate/bisphosphoglycerate mutase, ev=2e-17, 35% identity YP_612536.1 PFAM: beta-lactamase-like: (3.3e-07); KEGG: bca:BCE1814 metallo-beta-lactamase family protein, ev=1e-15, 24% identity YP_612537.1 PFAM: ABC transporter related: (9.1e-60) Transport-associated OB: (2.3e-11); SMART: ATPase: (7.2e-18); KEGG: atc:AGR_C_3650 AgtA, ev=9e-81, 48% identity YP_612538.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.4e-19); KEGG: sme:SMc04316 probable ferric iron transport system permease protein, ev=1e-155, 51% identity YP_612539.1 PFAM: extracellular solute-binding protein, family 1: (7.4e-08); KEGG: sme:SMc04317 iron-binding periplasmic protein, ev=1e-109, 61% identity YP_612540.1 PFAM: regulatory protein, DeoR: (5.8e-26) Helix-turn-helix, type 11: (6.4e-07); KEGG: vch:VCA0940 transcriptional regulator, DeoR family, ev=1e-34, 36% identity YP_612541.1 KEGG: ddi:DDB0168118 hypothetical protein, ev=4e-06, 28% identity YP_612542.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.13); KEGG: ava:Ava_1569 hypothetical protein, ev=7e-20, 25% identity YP_612543.1 PFAM: glycosyl transferase, family 2: (1.3e-33) polysaccharide deacetylase: (2.3e-31); KEGG: btk:BT9727_3202 glycosyl transferase and polysaccharide deacetylase fusion, ev=1e-153, 31% identity YP_612544.1 KEGG: rsp:RSP_3343 glycosyl transferase, ev=1e-06, 27% identity YP_612545.1 PFAM: regulatory protein, MarR: (1.3e-15); KEGG: pha:PSHAa2967 transcriptional regulator, ev=6e-29, 39% identity YP_612546.1 TIGRFAM: L-2,4-diaminobutyric acid acetyltransferase: (3.8e-63); PFAM: GCN5-related N-acetyltransferase: (3.3e-12); KEGG: vfi:VFA1122 L-2,4-diaminobutyric acid acetyltransferase, ev=7e-34, 43% identity YP_612547.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde YP_612548.1 N-acetyldiaminobutyrate dehydratase; catalyzes the formation of the osmoprotectant ecotoine from gamma-N-acetyl-alpha,gamma-diaminobutyric acid YP_612549.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP YP_612550.1 Catalyzes the cycloisomerization of cis,cis-muconate YP_612551.1 PFAM: protein of unknown function DUF849: (1e-49); KEGG: sil:SPOA0042 hypothetical protein, ev=1e-130, 79% identity YP_612552.1 KEGG: bmb:BruAb2_0580 protocatechuate 3,4-dioxygenase, alpha subunit, ev=4e-77, 68% identity; TIGRFAM: Protocatechuate 3,4-dioxygenase, alpha subunit: (1.8e-107); PFAM: intradiol ring-cleavage dioxygenase: (1.6e-09) YP_612553.1 TIGRFAM: Protocatechuate 3,4-dioxygenase, beta subunit: (5.9e-168); PFAM: intradiol ring-cleavage dioxygenase: (8.2e-70); KEGG: ret:RHE_PE00057 protocatechuate 3,4-dioxygenase beta chain protein, ev=3e-98, 68% identity YP_612554.1 TIGRFAM: 4-carboxymuconolactone decarboxylase: (8.3e-84); PFAM: Carboxymuconolactone decarboxylase: (4.7e-24); KEGG: sil:SPOA0045 4-carboxymuconolactone decarboxylase, ev=3e-53, 81% identity YP_612555.1 TIGRFAM: 3-oxoadipate enol-lactonase: (1.7e-123); PFAM: alpha/beta hydrolase fold: (1.4e-21); KEGG: sil:SPOA0434 3-oxoadipate enol-lactone hydrolase, ev=7e-76, 54% identity YP_612556.1 catalyzes the formation of protocatechuate from 4-hydroxybenzoate YP_612557.1 TIGRFAM: Pca transcription factor PcaQ: (6e-133); PFAM: regulatory protein, LysR: (5.9e-20) LysR, substrate-binding: (1.1e-35); KEGG: sil:SPOA0047 pca operon transcriptional activator PcaQ, ev=4e-98, 60% identity YP_612558.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_612559.1 PFAM: peptidase M19, renal dipeptidase: (1.6e-57); KEGG: sil:SPO1410 renal dipeptidase family protein, ev=1e-141, 64% identity YP_612560.1 PFAM: oxidoreductase-like: (3.4e-35) Oxidoreductase-like: (0.00051); KEGG: jan:Jann_3398 oxidoreductase-like, ev=6e-79, 51% identity YP_612561.1 PFAM: zinc finger, DksA/TraR C4-type: (4.2e-13); KEGG: sil:SPO1411 C4-type zinc finger protein, DksA/TraR family, ev=1e-37, 82% identity YP_612562.1 PFAM: GCN5-related N-acetyltransferase: (0.00014); KEGG: hch:HCH_03525 histone acetyltransferase HPA2/related acetyltransferase, ev=7e-21, 39% identity YP_612563.1 PFAM: Hemolysin-type calcium-binding region: (0.036); KEGG: ppu:PP2561 secreted hemolysin-type calcium-binding bacteriocin, , ev=4e-24, 36% identity YP_612564.1 TIGRFAM: Peptidase M3B, oligoendopeptidase-related clade 3: (1.2e-230); PFAM: peptidase M3A and M3B, thimet/oligopeptidase F: (5.1e-32) Oligopeptidase F: (3.2e-20); KEGG: sil:SPO1413 oligoendopeptidase F, ev=0.0, 86% identity YP_612565.1 PFAM: alpha/beta hydrolase fold: (6.4e-06); KEGG: sil:SPO1414 hydrolase, alpha/beta fold family, ev=5e-98, 58% identity YP_612566.1 PFAM: Sterol-binding: (3e-09); KEGG: sil:SPO1415 sterol carrier family protein, ev=1e-33, 73% identity YP_612567.1 PFAM: TPR repeat: (0.014) Tetratricopeptide TPR_2: (5.1e-05); SMART: Tetratricopeptide region: (0.00062); KEGG: sil:SPO1416 TPR domain protein, ev=4e-53, 60% identity YP_612568.1 PFAM: helicase-like: (9e-12); KEGG: sil:SPO1417 helicase, , ev=0.0, 76% identity YP_612569.1 PFAM: RNA-binding S4: (1.2e-14); KEGG: jan:Jann_3310 RNA-binding S4, ev=8e-30, 62% identity YP_612570.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding: (4.5e-07); KEGG: sil:SPO1419 iron-sulfur cluster-binding protein, ev=3e-60, 89% identity YP_612571.1 PFAM: transcription factor CarD: (6.8e-33); KEGG: sil:SPO1420 transcriptional regulator, CarD family, ev=9e-83, 92% identity YP_612572.1 TIGRFAM: cobalamin 5'-phosphate synthase: (3.7e-15); PFAM: cobalamin-5-phosphate synthase CobS: (4.8e-21); KEGG: sil:SPO1422 cobalamin 5'-phosphate synthase, ev=2e-68, 57% identity YP_612573.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_612574.1 TIGRFAM: Potassium efflux system protein: (9.4e-95); PFAM: TrkA-N: (4.1e-30) sodium/hydrogen exchanger: (1.7e-60); KEGG: sil:SPO1424 glutathione-regulated potassium-efflux system protein, ev=0.0, 75% identity YP_612575.1 KEGG: bba:Bd1322 sensory protein, ev=2e-41, 29% identity YP_612576.1 PFAM: regulatory proteins, AsnC/Lrp: (1e-25); KEGG: sil:SPO1425 transcriptional regulator, AsnC family, ev=5e-56, 70% identity YP_612577.1 KEGG: sil:SPO1426 4-hydroxyphenylpyruvate dioxygenase, ev=0.0, 85% identity; TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase: (1.6e-164); PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (9.9e-13) YP_612578.1 KEGG: sil:SPO1427 hypothetical protein, ev=1e-132, 39% identity YP_612579.1 PFAM: protein of unknown function DUF541: (7.6e-53); KEGG: sil:SPO1429 outer membrane protein, 28Kda, ev=5e-35, 40% identity YP_612580.1 KEGG: sil:SPO1431 O-acetylhomoserine aminocarboxypropyltransferase, ev=0.0, 92% identity; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase: (8e-236); PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes: (1.2e-171) YP_612581.1 KEGG: sil:SPO1769 hypothetical protein, ev=1e-138, 70% identity YP_612582.1 KEGG: sil:SPO1034 hypothetical protein, ev=9e-73, 45% identity YP_612583.1 PFAM: MaoC-like dehydratase: (2.4e-37); KEGG: sil:SPO3152 MaoC domain protein, ev=2e-69, 85% identity YP_612584.1 TIGRFAM: HAD-superfamily subfamily IIA hydrolase, hypothetical 3: (9.6e-27) HAD-superfamily hydrolase, subfamily IIA: (6.4e-25); PFAM: Haloacid dehalogenase-like hydrolase: (0.00081); KEGG: sil:SPO3151 HAD-superfamily subfamily IIA hydrolase, TIGR01459, ev=1e-137, 78% identity YP_612585.1 PFAM: helicase-like: (6.3e-30) DbpA, RNA-binding: (1e-10) DEAD/DEAH box helicase-like: (5.7e-61); KEGG: jan:Jann_1574 DEAD/DEAH box helicase-like, ev=0.0, 56% identity YP_612586.1 PFAM: peptidase M48, Ste24p: (2.3e-07); KEGG: sil:SPO0939 peptidase, M48 family, ev=8e-32, 36% identity YP_612587.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_612588.1 PFAM: GumN: (1.1e-10); KEGG: sil:SPO3145 GumN family protein, ev=3e-80, 49% identity YP_612589.1 PFAM: GumN: (2.4e-29); KEGG: sil:SPO3146 GumN family protein, ev=7e-55, 39% identity YP_612590.1 KEGG: sil:SPO3144 hypothetical protein, ev=4e-84, 68% identity YP_612591.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_612592.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth YP_612595.1 PFAM: protein of unknown function DUF6, transmembrane: (7.8e-13); KEGG: sil:SPO0889 membrane protein, , ev=2e-70, 54% identity YP_612596.1 KEGG: sil:SPO0890 lipase, , ev=4e-78, 63% identity YP_612597.1 PFAM: amidohydrolase: (0.0053) Amidohydrolase 3: (0.00054); KEGG: sil:SPO0891 alkylphosphonate utilization protein PhnM, , ev=1e-144, 68% identity YP_612598.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_612599.1 KEGG: sil:SPO0893 phosphoribosylaminoimidazole carboxylase, catalytic subunit, ev=4e-76, 88% identity; TIGRFAM: phosphoribosylaminoimidazole carboxylase, catalytic subunit: (1.1e-91); PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase: (4.1e-86) YP_612600.1 PFAM: Phenazine biosynthesis PhzC/PhzF protein: (1.8e-21); KEGG: sil:SPO0897 phenazine biosynthesis protein, PhzF family, ev=1e-109, 67% identity YP_612601.1 PFAM: glutathione-dependent formaldehyde-activating, GFA: (4.9e-13); KEGG: ccr:CC1514 hypothetical protein, ev=9e-20, 44% identity YP_612602.1 KEGG: mth:MTH293 hypothetical protein, ev=8e-40, 49% identity YP_612603.1 PFAM: phosphate transporter: (2.3e-127); KEGG: sil:SPO0967 phosphate transporter family protein, ev=0.0, 72% identity YP_612604.1 KEGG: sil:SPO0896 hypothetical protein, ev=7e-20, 66% identity YP_612605.1 PFAM: heat shock protein Hsp20: (2.5e-17); KEGG: sil:SPO0895 heat shock protein, Hsp20 family, ev=1e-64, 89% identity YP_612606.1 PFAM: protein of unknown function DUF465: (5.9e-08); KEGG: sil:SPO0894 hypothetical protein, ev=3e-24, 75% identity YP_612607.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from Escherichia coli involved in cysteine biosynthesis YP_612608.1 PFAM: ferredoxin: (2.5e-09) adenylyl cyclase class-3/4/guanylyl cyclase: (2.1e-09); KEGG: sil:SPO0901 adenylate/guanylate cyclase, ev=0.0, 58% identity YP_612609.1 TIGRFAM: thioredoxin reductase: (4.8e-176); PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (4.6e-28); KEGG: sil:SPO0903 thioredoxin-disulfide reductase, ev=1e-162, 90% identity YP_612610.1 PFAM: regulatory proteins, AsnC/Lrp: (5.6e-22); KEGG: sil:SPO0904 leucine-responsive regulatory protein, , ev=7e-80, 89% identity YP_612611.1 KEGG: sil:SPO0905 hypothetical protein, ev=7e-86, 60% identity YP_612613.1 PFAM: protein of unknown function DUF152: (2e-55); KEGG: sil:SPO0906 conserved hypothetical protein TIGR00726, ev=8e-98, 70% identity YP_612614.1 PFAM: protein of unknown function DUF185: (5.6e-45); KEGG: sil:SPO0907 hypothetical protein, ev=1e-136, 68% identity YP_612615.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_612616.1 PFAM: protein of unknown function DUF526: (8.4e-17); KEGG: sil:SPO0909 hypothetical protein, ev=2e-33, 89% identity YP_612617.1 KEGG: sil:SPO0910 hypothetical protein, ev=8e-73, 75% identity YP_612618.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_612619.1 TIGRFAM: Secretion chaperone CsaA: (4.8e-61); PFAM: t-RNA-binding region: (4.2e-16); KEGG: sil:SPO0912 chaperonin CsaA, ev=3e-49, 81% identity YP_612620.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region: (1.3e-29) D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding: (4.7e-73); KEGG: sil:SPO0913 D-isomer specific 2-hydroxyacid dehydrogenase family protein, ev=1e-133, 75% identity YP_612621.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_612622.1 KEGG: sil:SPO0915 hypothetical protein, ev=4e-65, 82% identity YP_612623.1 catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_612624.1 PFAM: regulatory protein, MarR: (6.5e-10); KEGG: sil:SPO0919 transcriptional regulator, MarR family, ev=2e-27, 46% identity YP_612625.1 TIGRFAM: Secretion protein HlyD: (1.3e-48); KEGG: sil:SPO0920 efflux transporter, RND family, MFP subunit, ev=1e-98, 57% identity YP_612626.1 PFAM: acriflavin resistance protein: (9.5e-69); KEGG: sil:SPO0921 transporter, AcrB/AcrD/AcrF family, ev=0.0, 72% identity YP_612627.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_612628.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine YP_612629.1 KEGG: sil:SPO0925 4-amino-4-deoxychorismate lyase, ev=7e-56, 53% identity YP_612630.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_612631.1 PFAM: response regulator receiver: (7e-21); KEGG: sil:SPO0931 response regulator, ev=6e-82, 66% identity YP_612632.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (3.4e-20); KEGG: rsp:RSP_0812 glyoxalase I (lactoylglutathione lyase), ev=4e-67, 91% identity YP_612633.1 KEGG: sil:SPO0933 hypothetical protein, ev=2e-29, 67% identity YP_612634.1 PFAM: regulatory protein, LysR: (1.4e-14) LysR, substrate-binding: (2.1e-05); KEGG: sil:SPO0588 transcriptional regulator, LysR family, ev=7e-32, 31% identity YP_612635.1 PFAM: protein of unknown function DUF427: (5.6e-28); KEGG: sil:SPO2858 hypothetical protein, ev=3e-41, 72% identity YP_612636.1 PFAM: peptidase M24: (3.3e-09); KEGG: sil:SPO2857 metallopeptidase, family M24, ev=0.0, 70% identity YP_612637.1 PFAM: Cobalt chelatase, CobT subunit: (3.5e-268); SMART: von Willebrand factor, type A: (2.1e-10); KEGG: sil:SPO2855 cobalt chelatase, pCobT subunit, ev=0.0, 84% identity YP_612638.1 TIGRFAM: cobalt chelatase, pCobS small subunit: (4.1e-215); PFAM: ATPase associated with various cellular activities, AAA_5: (1.5e-08); KEGG: sil:SPO2853 cobalt chelatase, CobS subunit, ev=1e-176, 92% identity YP_612639.1 KEGG: sil:SPO2852 CzcN domain protein, ev=2e-77, 68% identity YP_612640.1 PFAM: heat shock protein DnaJ-like: (8.6e-06); KEGG: sil:SPO2850 DnaJ domain protein, ev=1e-106, 86% identity YP_612641.1 PFAM: BolA-like protein: (5.9e-13); KEGG: sil:SPO2849 BolA protein, truncation, ev=1e-24, 65% identity YP_612642.1 KEGG: sil:SPO2848 hypothetical protein, ev=4e-30, 53% identity YP_612643.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_612644.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_612645.1 KEGG: mba:Mbar_A0126 hypothetical protein, ev=6e-07, 30% identity YP_612646.1 PFAM: AsmA: (2.4e-07); KEGG: sil:SPO0945 AsmA family protein, ev=1e-138, 41% identity YP_612647.1 PFAM: phosphoglucomutase/phosphomannomutase C terminal: (0.00053) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I: (2e-28) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II: (1e-25) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III: (0.0012); KEGG: sil:SPO0946 phosphomannomutase/phosphoglucomutase, ev=0.0, 90% identity YP_612648.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_612649.1 KEGG: sil:SPO0948 capsular polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family, ev=1e-136, 65% identity YP_612650.1 PFAM: ABC transporter related: (3.7e-10); SMART: ATPase: (9.6e-07); KEGG: sil:SPO0949 capsular polysaccharide export ATP-binding protein, ev=1e-107, 84% identity YP_612651.1 PFAM: Uracil-DNA glycosylase superfamily: (5.3e-05); KEGG: sil:SPO0950 uracil-DNA glycosylase, , ev=1e-80, 72% identity YP_612652.1 KEGG: sil:SPO0951 hypothetical protein, ev=2e-89, 66% identity YP_612653.1 YghU; B2989; one of eight glutathione transferase proteins from E. coli YP_612654.1 PFAM: protein of unknown function DUF88: (0.0004); KEGG: jan:Jann_0048 protein of unknown function DUF88, ev=3e-85, 64% identity YP_612655.1 KEGG: bja:blr5357 hypothetical protein, ev=3e-22, 50% identity YP_612656.1 KEGG: sil:SPO0954 hypothetical protein, ev=6e-69, 72% identity YP_612657.1 PFAM: GcrA cell cycle regulator: (2.2e-57); KEGG: sil:SPO0956 hypothetical protein, ev=3e-86, 81% identity YP_612658.1 PFAM: ABC-2 type transporter: (4.4e-32); KEGG: sil:SPO0957 ABC transporter, permease protein, ev=1e-111, 74% identity YP_612659.1 PFAM: protein of unknown function DUF6, transmembrane: (2.7e-15); KEGG: sil:SPO0959 membrane protein, , ev=1e-108, 69% identity YP_612660.1 DapATase; functions in arginine biosynthetic pathway; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_612661.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_612662.1 PFAM: phosphate transporter: (1e-105); KEGG: sil:SPO0967 phosphate transporter family protein, ev=1e-143, 53% identity YP_612663.1 PFAM: NUDIX hydrolase: (3.6e-17); KEGG: sil:SPO0968 hydrolase, NUDIX family, ev=2e-45, 58% identity YP_612664.1 TIGRFAM: ATP-dependent helicase HrpB: (0); PFAM: helicase-like: (9.2e-10) helicase-associated region: (2.8e-09) DEAD/DEAH box helicase-like: (6.1e-05) Helicase ATP-dependent-like: (3.7e-75); KEGG: sil:SPO0972 ATP-dependent helicase HrpB, ev=0.0, 71% identity YP_612665.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins YP_612666.1 required for 70S ribosome assembly YP_612667.1 KEGG: sil:SPO0975 hypothetical protein, ev=9e-12, 39% identity YP_612668.1 PFAM: protein of unknown function DUF461: (4e-38); KEGG: sil:SPO0976 hypothetical protein, ev=4e-38, 57% identity YP_612669.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_612670.1 PFAM: low molecular weight phosphotyrosine protein phosphatase: (1.2e-45); KEGG: sil:SPO0979 low molecular weight phosphotyrosine protein phosphatase, ev=1e-43, 58% identity YP_612671.1 PFAM: regulatory protein, LysR: (1.6e-17) LysR, substrate-binding: (1.4e-05); KEGG: sil:SPO0980 transcriptional regulator, LysR family, ev=1e-130, 72% identity YP_612672.1 KEGG: rsp:RSP_2018 hypothetical protein, ev=7e-18, 50% identity YP_612673.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_612674.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_612675.1 PFAM: fumarate reductase/succinate dehydrogenase flavoprotein-like: (5.1e-05) HI0933-like protein: (4.4e-194) FAD dependent oxidoreductase: (0.00012) FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (0.00042); KEGG: sil:SPO1188 conserved hypothetical protein TIGR00275, ev=1e-170, 74% identity YP_612676.1 TIGRFAM: Cell division protein FtsW: (5.8e-141); PFAM: cell cycle protein: (7.6e-63); KEGG: sil:SPO1194 cell division protein FtsW, ev=0.0, 85% identity YP_612677.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_612678.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_612679.1 KEGG: sil:SPO1198 hypothetical protein, ev=2e-30, 73% identity YP_612680.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_612681.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_612682.1 PFAM: cell division protein FtsQ: (3.2e-10); KEGG: sil:SPO1202 cell division protein FtsQ, ev=1e-102, 64% identity YP_612683.1 PFAM: cell division protein FtsA: (2e-53); KEGG: sil:SPO1203 cell division protein FtsA, ev=0.0, 84% identity YP_612684.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_612685.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_612686.1 KEGG: sil:SPO1206 competence lipoprotein ComL, , ev=1e-123, 76% identity YP_612687.1 TIGRFAM: DNA repair protein RecN: (1.6e-139); PFAM: SMC protein-like: (3.6e-08); KEGG: sil:SPO1207 DNA repair protein RecN, ev=0.0, 74% identity YP_612688.1 PFAM: Cl- channel, voltage gated: (3.8e-25); KEGG: sil:SPO1208 voltage-gated chloride channel family protein, ev=0.0, 71% identity YP_612689.1 KEGG: sil:SPO0934 membrane protein, , ev=2e-85, 72% identity YP_612690.1 PFAM: nitroreductase: (2.2e-06); KEGG: sil:SPO0935 nitroreductase family protein, ev=9e-78, 73% identity YP_612691.1 PFAM: protein of unknown function DUF167: (2.6e-18); KEGG: sil:SPO0937 hypothetical protein, ev=2e-20, 56% identity YP_612692.1 KEGG: sil:SPO0938 hypothetical protein, ev=9e-29, 81% identity YP_612693.1 PFAM: peptidase M48, Ste24p: (2.8e-08); KEGG: sil:SPO0939 peptidase, M48 family, ev=7e-57, 49% identity YP_612694.1 PFAM: protein of unknown function UPF0029: (4.7e-17); KEGG: sil:SPO0940 hypothetical protein, ev=1e-49, 84% identity YP_612695.1 KEGG: sil:SPO0941 hypothetical protein, ev=1e-12, 46% identity YP_612696.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_612697.1 SMART: extracellular solute-binding protein, family 3: (7e-06); KEGG: hch:HCH_01375 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain, ev=3e-21, 27% identity YP_612698.1 PFAM: RNA binding S1: (4.1e-24); SMART: Resolvase, RNase H-like fold: (8.8e-34); KEGG: sil:SPOA0306 S1 RNA binding domain protein, ev=0.0, 78% identity YP_612699.1 KEGG: sil:SPO2845 hypothetical protein, ev=2e-89, 45% identity YP_612700.1 KEGG: sil:SPO2843 hypothetical protein, ev=3e-18, 40% identity YP_612701.1 TIGRFAM: Peptidase M1, alanyl aminopeptidase: (0); PFAM: peptidase M1, membrane alanine aminopeptidase: (5.2e-51); KEGG: sil:SPO2841 aminopeptidase N, ev=0.0, 71% identity YP_612702.1 PFAM: NAD(P) transhydrogenase, beta subunit: (1.3e-251); KEGG: sil:SPO2819 NAD(P)+ transhydrogenase, beta subunit, ev=0.0, 86% identity YP_612703.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_612705.1 PFAM: peptidase C26: (1.1e-79); KEGG: sil:SPO2837 hypothetical protein, ev=1e-117, 81% identity YP_612706.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_612707.1 KEGG: sil:SPO2818 hypothetical protein, ev=1e-158, 66% identity YP_612708.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.2e-39); KEGG: sil:SPO2816 peptide/nickel/opine uptake family ABC transporter, permease protein, ev=1e-110, 65% identity YP_612709.1 PFAM: binding-protein-dependent transport systems inner membrane component: (3.7e-49); KEGG: sil:SPO2815 peptide/nickel/opine uptake family ABC transporter, permease protein, ev=1e-177, 92% identity YP_612710.1 PFAM: extracellular solute-binding protein, family 5: (4.8e-54); KEGG: sil:SPO2814 peptide/opine/nickel uptake family ABC transporter, periplasmic substrate-binding protein, ev=0.0, 79% identity YP_612711.1 PFAM: ABC transporter related: (3.6e-53) Oligopeptide/dipeptide ABC transporter-like: (1.4e-09); SMART: ATPase: (9.6e-17); KEGG: sil:SPO2813 peptide/nickel/opine uptake family ABC transporter, ATP-binding protein, , ev=0.0, 82% identity YP_612712.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine YP_612713.1 KEGG: sil:SPO2811 amidohydrolase family protein, ev=1e-168, 74% identity; TIGRFAM: Peptidase M20D, amidohydrolase: (6.8e-130); PFAM: peptidase M20: (2.1e-65) peptidase dimerisation: (1.8e-10) YP_612714.1 KEGG: sil:SPO2808 amidohydrolase family protein, ev=0.0, 87% identity; TIGRFAM: Peptidase M20D, amidohydrolase: (2.2e-133); PFAM: peptidase M20: (3.8e-64) peptidase dimerisation: (0.00021) YP_612717.1 PFAM: glycosyl transferase, group 1: (2.1e-40); KEGG: jan:Jann_3847 glycosyl transferase, group 1, ev=1e-105, 57% identity YP_612718.1 PFAM: glycosyl transferase, group 1: (0.0014) Three-deoxy-D-manno-octulosonic-acid transferase-like: (5.2e-59); KEGG: sil:SPO2800 3-deoxy-D-manno-octulosonic acid transferase, ev=1e-147, 62% identity YP_612719.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_612720.1 KEGG: jan:Jann_3286 hypothetical protein, ev=3e-17, 45% identity YP_612721.1 KEGG: sil:SPO2798 hypothetical protein, ev=4e-90, 71% identity YP_612722.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_612723.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_612724.1 KEGG: sil:SPO2796 phosphoglycolate phosphatase, ev=3e-88, 74% identity; TIGRFAM: HAD-superfamily hydrolase subfamily IA, variant 3: (2.7e-05) HAD-superfamily hydrolase, subfamily IA, variant 1: (4e-05); PFAM: Haloacid dehalogenase-like hydrolase: (5.6e-28) YP_612725.1 KEGG: sil:SPO1770 hypothetical protein, ev=1e-41, 60% identity YP_612726.1 PFAM: DegT/DnrJ/EryC1/StrS aminotransferase: (4.2e-48); KEGG: sil:SPO2795 aminotransferase, DegT/DnrJ/EryC1/StrS family, ev=0.0, 79% identity YP_612727.1 PFAM: acyl-CoA dehydrogenase-like: (3.6e-55) Acyl-CoA dehydrogenase, type 2-like: (3.8e-13); KEGG: sil:SPO2793 isovaleryl-CoA dehydrogenase, ev=0.0, 89% identity YP_612729.1 PFAM: OmpW: (6.3e-45); KEGG: sil:SPO2792 outer membrane protein OmpW, ev=2e-67, 61% identity YP_612730.1 PFAM: AMP-dependent synthetase and ligase: (3.3e-94); KEGG: sil:SPO2791 acetyl-coenzyme A synthetase, ev=0.0, 78% identity YP_612732.1 PFAM: carboxyl transferase: (1.3e-204); KEGG: sil:SPO2790 methylcrotonyl-CoA carboxylase, beta subunit, ev=0.0, 91% identity YP_612733.1 PFAM: biotin/lipoyl attachment: (2.9e-21) ATP-dependent carboxylate-amine ligase-like, ATP-grasp: (0.0042) Carbamoyl-phosphate synthase L chain, ATP-binding: (1.7e-93) Carbamoyl-phosphate synthetase large chain-like: (2.4e-43) biotin carboxylase-like: (2.9e-41); KEGG: sil:SPO2789 methylcrotonyl-CoA carboxylase, alpha subunit, ev=0.0, 77% identity YP_612734.1 catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA YP_612735.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_612736.1 Catalyzes the transfer of electrons from NADH to quinone YP_612737.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_612738.1 Catalyzes the transfer of electrons from NADH to quinone YP_612739.1 Catalyzes the transfer of electrons from NADH to quinone YP_612741.1 catalyzes the transfer of electrons from NADH to ubiquinone YP_612742.1 KEGG: sil:SPO2778 hypothetical protein, ev=7e-23, 68% identity YP_612743.1 part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_612744.1 KEGG: sil:SPO2776 hypothetical protein, ev=3e-14, 38% identity YP_612745.1 KEGG: sil:SPO2775 hypothetical protein, ev=4e-27, 44% identity YP_612746.1 Catalyzes the transfer of electrons from NADH to quinone YP_612747.1 KEGG: sil:SPO2773 lipoprotein, , ev=6e-41, 64% identity YP_612748.1 Catalyzes the transfer of electrons from NADH to quinone YP_612749.1 Catalyzes the transfer of electrons from NADH to quinone YP_612750.1 PFAM: Carboxymuconolactone decarboxylase: (1.9e-13); KEGG: sil:SPO2768 4-carboxymuconolactone decarboxylase, , ev=5e-53, 84% identity YP_612751.1 Catalyzes the transfer of electrons from NADH to quinone YP_612752.1 Catalyzes the transfer of electrons from NADH to quinone YP_612753.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_612754.1 Catalyzes the transfer of electrons from NADH to quinone YP_612755.1 Catalyzes the transfer of electrons from NADH to quinone YP_612756.1 KEGG: sil:SPO2762 biotin--acetyl-CoA-carboxylase ligase, ev=5e-97, 72% identity; TIGRFAM: Biotin--acetyl-CoA-carboxylase ligase: (6.6e-33); PFAM: biotin protein ligase-like: (6.5e-07) biotin/lipoate A/B protein ligase: (6.1e-16) YP_612757.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_612758.1 PFAM: beta-lactamase-like: (1.8e-24) RNA-metabolising metallo-beta-lactamase: (2.8e-07); KEGG: sil:SPO2760 metallo-beta-lactamase family protein, ev=0.0, 74% identity YP_612759.1 PFAM: triosephosphate isomerase: (9.1e-116); KEGG: jan:Jann_1733 triosephosphate isomerase, ev=2e-88, 66% identity YP_612760.1 PFAM: HesB/YadR/YfhF: (1.1e-33); KEGG: sil:SPO2620 iron-sulfur cluster assembly accessory protein, ev=6e-51, 83% identity YP_612761.1 PFAM: protein of unknown function DUF59: (5.3e-26); KEGG: sil:SPO2619 hypothetical protein, ev=3e-55, 80% identity YP_612762.1 KEGG: sil:SPO2618 hypothetical protein, ev=5e-26, 67% identity YP_612763.1 PFAM: band 7 protein: (6.5e-61); KEGG: sil:SPO2617 SPFH domain/band 7 family protein, ev=1e-135, 85% identity YP_612764.1 TIGRFAM: S6 modification enzyme RimK: (6.5e-102); PFAM: protein of unknown function DUF201: (7.9e-06) protein of unknown function DUF785: (2.5e-29) RimK-like ATP-grasp: (8.3e-79); KEGG: syw:SYNW1384 possible ribosomal protein S6 modification protein, ev=1e-116, 50% identity YP_612765.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_612768.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase: (5.2e-17); KEGG: sil:SPO2615 NADH-dependent flavin oxidoreductase, Oye family, ev=2e-70, 56% identity YP_612769.1 KEGG: sil:SPO2615 NADH-dependent flavin oxidoreductase, Oye family, ev=3e-20, 60% identity YP_612770.1 KEGG: sil:SPO2613 ATP-dependent protease La, ev=0.0, 86% identity; TIGRFAM: ATP-dependent protease La: (0); PFAM: peptidase S16, lon-like: (1.1e-34) AAA ATPase, central region: (4.1e-48) ATPase associated with various cellular activities, AAA_5: (0.00026); SMART: ATPase: (6e-14) YP_612771.1 PFAM: phage integrase: (3.2e-24); KEGG: rsp:RSP_3805 possible integrase, ev=9e-93, 54% identity YP_612774.1 KEGG: rsp:RSP_3792 hypothetical protein, ev=2e-76, 59% identity YP_612775.1 KEGG: bpm:BURPS1710b_1662 gp47, ev=2e-17, 26% identity YP_612776.1 PFAM: protein of unknown function DUF1364: (2.1e-18); KEGG: ecj:JW0537 hypothetical protein, ev=2e-13, 54% identity YP_612778.1 KEGG: bhe:BH06850 exonuclease, ev=2e-41, 43% identity YP_612779.1 PFAM: ERF: (2.6e-12); KEGG: bhe:BH06860 phage related protein, ev=4e-16, 28% identity YP_612784.1 PFAM: peptidase S24, S26A and S26B: (0.022); SMART: Helix-turn-helix type 3: (2.6e-07); KEGG: rsp:RSP_3771 hypothetical protein, ev=8e-38, 41% identity YP_612787.1 KEGG: ava:Ava_B0325 hypothetical protein, ev=9e-07, 33% identity YP_612788.1 PFAM: endodeoxyribonuclease RusA: (0.008); KEGG: nfa:nfa39720 hypothetical protein, ev=3e-06, 39% identity YP_612789.1 KEGG: bbr:BB1683 phage-related hypothetical protein, ev=1e-15, 38% identity YP_612791.1 TIGRFAM: single-strand binding protein: (4.7e-55); PFAM: single-strand binding protein/Primosomal replication protein n: (9.2e-33); KEGG: sil:SPO1637 single-strand binding protein, ev=7e-66, 72% identity YP_612795.1 PFAM: Terminase small subunit: (4.2e-30); KEGG: gox:GOX2458 phage terminase small subunit, ev=3e-25, 45% identity YP_612796.1 PFAM: protein of unknown function DUF264: (1.3e-31); KEGG: pfl:PFL_3766 hypothetical protein, ev=1e-117, 52% identity YP_612797.1 KEGG: rru:Rru_A2589 hypothetical protein, ev=1e-42, 33% identity YP_612798.1 PFAM: phage head morphogenesis protein, SPP1 gp7: (3.9e-07); KEGG: ypk:y2207 hypothetical protein, ev=4e-57, 36% identity YP_612799.1 KEGG: ypk:y2206 hypothetical protein, ev=7e-07, 25% identity YP_612800.1 KEGG: bbr:BB3501 hypothetical protein, ev=1e-120, 67% identity YP_612802.1 KEGG: bpe:BP3375 hypothetical protein, ev=1e-17, 37% identity YP_612805.1 KEGG: bbr:BB3496 hypothetical protein, ev=9e-21, 43% identity YP_612806.1 KEGG: mlo:mlr8015 hypothetical protein, ev=5e-07, 28% identity YP_612810.1 KEGG: rpa:RPA3130 transcriptional regulator, XRE family, ev=3e-30, 53% identity YP_612811.1 KEGG: rpa:RPA3131 hypothetical protein, ev=1e-30, 60% identity YP_612813.1 KEGG: sil:SPO3110 TonB domain protein, , ev=9e-10, 40% identity YP_612814.1 TIGRFAM: Tape measure domain: (6.6e-14); KEGG: rsp:RSP_2059 potential phage tail tape measure protein, ev=1e-117, 28% identity YP_612815.1 KEGG: nar:Saro_0661 hypothetical protein, ev=2e-26, 25% identity YP_612816.1 KEGG: pub:SAR11_0932 hypothetical protein, ev=2e-31, 28% identity YP_612821.1 PFAM: protein of unknown function DUF847: (8.8e-67); KEGG: bmb:BruAb1_0990 secretion activator protein, hypothetical, ev=2e-43, 39% identity YP_612823.1 PFAM: regulatory protein, LuxR: (3.4e-17) response regulator receiver: (1e-22); KEGG: sil:SPO0161 DNA-binding response regulator, LuxR family, ev=1e-50, 51% identity YP_612824.1 PFAM: response regulator receiver: (2.6e-05); KEGG: lic:LIC13330 response regulator, ev=8e-14, 35% identity YP_612825.1 KEGG: rru:Rru_A1875 multi-sensor signal transduction histidine kinase, ev=1e-46, 32% identity; TIGRFAM: PAS: (8.4e-07); PFAM: ATP-binding region, ATPase-like: (2.3e-31) histidine kinase A-like: (2.2e-11) PAS fold-3: (3.7e-21); SMART: PAC motif: (1.7e-08) YP_612826.1 PFAM: regulatory protein, LysR: (2.7e-20) LysR, substrate-binding: (2.2e-21); KEGG: xcv:XCV2178 transcriptional regulator, LysR family, ev=1e-102, 66% identity YP_612827.1 PFAM: NADH/Ubiquinone/plastoquinone (complex I): (3e-26); KEGG: jan:Jann_1259 NADH dehydrogenase (quinone), ev=0.0, 65% identity YP_612828.1 KEGG: jan:Jann_1258 hypothetical protein, ev=0.0, 58% identity YP_612829.1 PFAM: Amidohydrolase 3: (9.2e-81); KEGG: sil:SPO1605 hypothetical protein, ev=0.0, 62% identity YP_612830.1 PFAM: extracellular solute-binding protein, family 1: (0.00028); KEGG: sil:SPO1606 spermidine/putrescine ABC transporter, periplasmic substrate-binding protein, ev=1e-152, 76% identity YP_612831.1 PFAM: binding-protein-dependent transport systems inner membrane component: (0.00096); KEGG: sil:SPO1607 spermidine/putrescine ABC transporter, permease protein, ev=1e-119, 80% identity YP_612832.1 PFAM: binding-protein-dependent transport systems inner membrane component: (2e-09); KEGG: sil:SPO1608 spermidine/putrescine ABC transporter, permease protein, ev=1e-127, 74% identity YP_612833.1 KEGG: sil:SPO1609 spermidine/putrescine ABC transporter, ATP-binding component, ev=1e-122, 63% identity; TIGRFAM: spermidine/putrescine ABC transporter ATP-binding subunit: (1.6e-148); PFAM: ABC transporter related: (1.7e-61) TOBE: (0.0011) Transport-associated OB: (1.8e-18); SMART: ATPase: (4.1e-23) YP_612834.1 PFAM: histidine kinase, HAMP region: (1.8e-09) chemotaxis sensory transducer: (1.2e-84); KEGG: sme:SMc01104 probable chemoreceptor (methyl-accepting chemotaxis) transmembrane protein, ev=4e-93, 47% identity YP_612837.1 PFAM: peptidase C1A, papain: (2.9e-08); KEGG: lic:LIC20197 cysteine protease, ev=3e-24, 30% identity YP_612838.1 PFAM: OmpA/MotB: (1.1e-28) peptidase C14, caspase catalytic subunit p20: (4.8e-11); KEGG: pca:Pcar_2377 OmpA domain protein, ev=1e-16, 46% identity YP_612839.1 PFAM: regulatory protein, LysR: (9.2e-18) LysR, substrate-binding: (3.4e-25); KEGG: sil:SPO1640 transcriptional regulator, LysR family, ev=1e-50, 39% identity YP_612840.1 PFAM: glucose-methanol-choline oxidoreductase: (8.2e-97) FAD dependent oxidoreductase: (0.00062) GMC oxidoreductase: (7.6e-30) FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (0.0024); KEGG: sil:SPOA0386 oxidoreductase, GMC family, ev=1e-159, 51% identity YP_612841.1 PFAM: Mandelate racemase/muconate lactonizing enzyme-like: (8.4e-08); KEGG: sil:SPOA0378 mandelate racemase/muconate lactonizing enzyme family protein, ev=1e-142, 63% identity YP_612842.1 PFAM: aldehyde dehydrogenase: (6.4e-209); KEGG: bbr:BB4965 probable aldehyde dehydrogenase, ev=1e-103, 43% identity YP_612843.1 PFAM: regulatory protein, LysR: (1.7e-17) LysR, substrate-binding: (7.2e-38); KEGG: sil:SPO0241 transcriptional regulator, LysR family, ev=1e-110, 64% identity YP_612844.1 PFAM: extracellular solute-binding protein, family 1: (7.9e-17); KEGG: sil:SPO0240 SN-glycerol-3-phophate ABC transporter, periplasmic SN-glycerol-3-phosphate-binding protein, ev=0.0, 87% identity YP_612845.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.8e-09); KEGG: sil:SPO0239 SN-glycerol-3-phosphate ABC transporter, permease protein, ev=1e-149, 88% identity YP_612846.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.9e-23); KEGG: sil:SPO0238 SN-glycerol-3-phosphate ABC transporter, permease protein, ev=1e-152, 93% identity YP_612847.1 part of the UgpABCE glycerol-3-phosphate uptake system YP_612848.1 PFAM: glycerophosphoryl diester phosphodiesterase: (1.4e-38); KEGG: sil:SPO0236 glycerophosphoryl diester phosphodiesterase, , ev=5e-90, 56% identity YP_612849.1 PFAM: Haloacid dehalogenase-like hydrolase: (1.2e-07); KEGG: rru:Rru_A1795 HAD-superfamily hydrolase, subfamily IIA, ev=7e-39, 39% identity YP_612850.1 PFAM: Na+/Pi-cotransporter: (3.3e-33); KEGG: sme:SMb21536 hypothetical protein, ev=1e-106, 41% identity YP_612851.1 PFAM: Phosphoglycerate mutase: (5.1e-35); KEGG: jan:Jann_2515 phosphoglycerate mutase, ev=3e-31, 42% identity YP_612853.1 PFAM: thioesterase superfamily: (2.8e-19); KEGG: ccr:CC0190 acyl-CoA thioester hydrolase, ev=9e-34, 53% identity YP_612854.1 PFAM: peptidase M20: (1.7e-34) peptidase dimerisation: (2.4e-22); KEGG: sil:SPO2597 peptidase, M20/M25/M40 family, ev=0.0, 75% identity YP_612855.2 catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine YP_612856.1 KEGG: rsp:RSP_2983 hypothetical protein, ev=2e-95, 50% identity YP_612857.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_612858.1 PFAM: DSBA oxidoreductase: (1.4e-24); KEGG: sil:SPO2591 27 kDa outer membrane protein, , ev=5e-85, 63% identity YP_612859.1 PFAM: peptidase M48, Ste24p: (2.5e-18) Tetratricopeptide TPR_2: (0.0011); KEGG: sil:SPO2590 peptidase, M48 family, ev=1e-132, 54% identity YP_612860.1 PFAM: aminotransferase, class I and II: (3.3e-50); KEGG: sil:SPO2589 aminotransferase, classes I and II, ev=1e-179, 82% identity YP_612861.1 PFAM: cell wall hydrolase/autolysin: (1.2e-58); KEGG: sil:SPO2588 N-acetylmuramoyl-L-alanine amidase, family 3, ev=1e-136, 61% identity YP_612862.1 KEGG: sil:SPO2587 penicillin-binding protein 1A, ev=0.0, 77% identity; TIGRFAM: Penicillin-binding protein 1A: (2.1e-205); PFAM: glycosyl transferase, family 51: (1.2e-73) penicillin-binding protein, transpeptidase: (1.3e-32) YP_612863.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_612864.1 PFAM: major facilitator superfamily MFS_1: (6.7e-21); KEGG: sco:SCO1457 transport protein, ev=8e-16, 27% identity YP_612865.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_612866.1 KEGG: sil:SPO2582 membrane protein, , ev=8e-97, 66% identity YP_612867.1 SMART: Helix-turn-helix type 3: (1.5e-07); KEGG: sil:SPO2581 DNA-binding protein, , ev=2e-86, 59% identity YP_612868.1 KEGG: sil:SPO2580 hypothetical protein, ev=4e-07, 38% identity YP_612869.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_612870.1 TIGRFAM: acetolactate synthase, large subunit, biosynthetic type: (1.1e-304); PFAM: thiamine pyrophosphate enzyme-like TPP-binding: (6.9e-67) thiamine pyrophosphate enzyme, central region: (3.1e-53) thiamine pyrophosphate enzyme-like TPP binding region: (2.1e-100); KEGG: sil:SPO2578 acetolactate synthase, large subunit, biosynthetic type, ev=0.0, 92% identity YP_612871.1 PFAM: regulatory protein, LuxR: (4.1e-23) response regulator receiver: (1.5e-38) Sigma-70, region 4 type 2: (0.00038); KEGG: sil:SPO2575 DNA-binding response regulator, LuxR family, ev=7e-92, 81% identity YP_612872.1 PFAM: ATP-binding region, ATPase-like: (5.1e-17) histidine kinase, dimerisation and phosphoacceptor region: (4.4e-16) Cache, type 2: (4e-21); KEGG: sil:SPO2574 sensor histidine kinase, ev=0.0, 77% identity YP_612873.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.00058); PFAM: TRAP dicarboxylate transporter- DctP subunit: (4.5e-49); KEGG: sil:SPO2573 bacterial extracellular solute-binding protein, family 7, ev=0.0, 88% identity YP_612874.1 KEGG: sil:SPO2572 hypothetical protein, ev=1e-114, 83% identity YP_612875.1 PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (1.1e-27); KEGG: sil:SPO2571 TRAP transporter, DctM subunit, , ev=0.0, 83% identity YP_612876.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (1.8e-20); KEGG: sil:SPO2570 glyoxalase family protein, ev=6e-45, 75% identity YP_612877.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate YP_612878.1 PFAM: RDD: (1.4e-10); KEGG: sil:SPO2568 RDD family protein, ev=4e-46, 63% identity YP_612879.1 KEGG: sil:SPO2567 hypothetical protein, ev=1e-49, 66% identity YP_612880.1 PFAM: glutamate-ammonia ligase adenylyltransferase: (3.4e-65); KEGG: sil:SPO2523 glutamate-ammonia ligase adenylyltransferase, ev=0.0, 68% identity YP_612881.1 KEGG: sil:SPO2522 hypothetical protein, ev=9e-23, 58% identity YP_612882.1 KEGG: sil:SPO2520 hypothetical protein, ev=1e-175, 77% identity YP_612883.1 KEGG: sil:SPO2519 hypothetical protein, ev=1e-65, 70% identity YP_612884.1 PFAM: luciferase-like: (4.3e-16); KEGG: sil:SPO2518 bacterial luciferase family protein, ev=1e-136, 75% identity YP_612885.1 PFAM: peptidase M48, Ste24p: (3.3e-22); KEGG: sil:SPO2517 peptidase, M48 family, ev=3e-97, 77% identity YP_612886.1 KEGG: sil:SPO2515 hypothetical protein, ev=0.0, 87% identity YP_612887.1 KEGG: sil:SPO2514 hypothetical protein, ev=1e-08, 50% identity YP_612888.1 KEGG: sil:SPO2513 hypothetical protein, ev=1e-119, 50% identity YP_612889.1 PFAM: AAA ATPase, central region: (7.3e-06) ATPase associated with various cellular activities, AAA_5: (7.7e-09); SMART: ATPase: (4.2e-11); KEGG: sil:SPO2512 ATPase, AAA family, ev=1e-141, 89% identity YP_612890.1 TIGRFAM: RNA polymerase-binding, DksA: (1.1e-65); PFAM: zinc finger, DksA/TraR C4-type: (1e-08); KEGG: sil:SPO2511 DnaK suppressor protein, , ev=5e-72, 86% identity YP_612891.1 PFAM: monooxygenase, FAD-binding: (1.7e-11) FAD dependent oxidoreductase: (1.7e-06); KEGG: sil:SPO2510 salicylate hydroxylase, ev=1e-135, 65% identity YP_612892.1 TIGRFAM: exodeoxyribonuclease III: (1.6e-75) exodeoxyribonuclease III (xth): (5.2e-73); PFAM: Endonuclease/exonuclease/phosphatase: (1.3e-33); KEGG: sil:SPO2509 exodeoxyribonuclease III, ev=1e-135, 85% identity YP_612895.1 PFAM: protein of unknown function DUF6, transmembrane: (7.4e-07); KEGG: sil:SPO2507 membrane protein, , ev=2e-78, 54% identity YP_612896.1 PFAM: HesB/YadR/YfhF: (1.2e-25); KEGG: sil:SPO2506 iron-sulfur cluster assembly family protein, ev=1e-49, 87% identity YP_612897.1 KEGG: sil:SPO2505 deoxyguanosinetriphosphate triphosphohydrolase, , ev=1e-162, 76% identity; TIGRFAM: Deoxyguanosinetriphosphate triphosphohydrolase: (3.7e-107); PFAM: metal-dependent phosphohydrolase, HD subdomain: (1.6e-17); SMART: Metal-dependent phosphohydrolase, HD region: (3.1e-12) YP_612898.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_612899.1 PFAM: Sporulation related: (1.6e-05); KEGG: sil:SPO2503 hypothetical protein, ev=4e-79, 48% identity YP_612900.1 PFAM: glycoside hydrolase, family 3-like: (7.8e-11); KEGG: sil:SPO2502 beta-N-acetylhexosaminidase, , ev=1e-123, 64% identity YP_612901.1 PFAM: chromosome segregation and condensation protein ScpA: (7.1e-07); KEGG: sil:SPO2501 segregation and condensation protein A, ev=1e-116, 80% identity YP_612902.1 PFAM: chromosome segregation and condensation protein ScpB: (6.8e-69); KEGG: sil:SPO2500 segregation and condensation protein B, ev=1e-95, 84% identity YP_612904.1 PFAM: major facilitator superfamily MFS_1: (1.1e-39); KEGG: mlo:mll7282 similar to multidrug-efflux transporter, ev=1e-76, 42% identity YP_612905.1 PFAM: regulatory proteins, AsnC/Lrp: (6.5e-18); KEGG: mlo:mlr7283 transcriptional regulator, ev=6e-46, 55% identity YP_612906.1 Catalyzes the deamination of dCTP to form dUTP YP_612907.1 PFAM: regulatory protein, MerR: (1.2e-08); KEGG: lma:LmjF35.0550 proteophosphoglycan ppg1, ev=2e-48, 23% identity YP_612908.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_612909.1 KEGG: sil:SPO2494 3-oxoacyl-(acyl-carrier-protein) synthase III, ev=1e-155, 86% identity; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) synthase III: (2.3e-156); PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal: (1.1e-53) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III: (1.5e-46) YP_612910.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_612911.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_612912.1 KEGG: sil:SPO2491 hypothetical protein, ev=1e-49, 59% identity YP_612913.1 KEGG: sil:SPO2490 lipoprotein, SmpA/OmlA family, ev=4e-42, 56% identity YP_612914.1 KEGG: sil:SPO2489 hypothetical protein, ev=1e-109, 81% identity YP_612915.1 PFAM: ABC transporter related: (6.5e-50); SMART: ATPase: (7.3e-17); KEGG: sil:SPO2488 ABC transporter, ATP-binding protein, ev=0.0, 82% identity YP_612916.1 PFAM: short-chain dehydrogenase/reductase SDR: (2.9e-13); KEGG: sil:SPO2487 3-hydroxyacyl-CoA dehydrogenase, type II, ev=1e-108, 78% identity YP_612917.1 KEGG: sil:SPO2486 hypothetical protein, ev=1e-79, 55% identity YP_612918.1 KEGG: sil:SPO2484 tyrosyl-tRNA synthetase, ev=0.0, 83% identity; TIGRFAM: tyrosyl-tRNA synthetase: (1.5e-109); PFAM: aminoacyl-tRNA synthetase, class Ib: (1.2e-96) YP_612919.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_612920.1 PFAM: protein of unknown function DUF985: (1.7e-63); KEGG: sil:SPO2479 hypothetical protein, ev=6e-56, 66% identity YP_612921.1 PFAM: protein of unknown function UPF0061: (3.7e-80); KEGG: sil:SPO2480 hypothetical protein, ev=0.0, 71% identity YP_612922.1 PFAM: helicase-like: (4.8e-35) DEAD/DEAH box helicase-like: (4.9e-67); KEGG: sme:SMb20880 ATP-dependent RNA helicase protein, ev=1e-139, 60% identity YP_612923.1 PFAM: ferric-uptake regulator: (4.4e-58); KEGG: sil:SPO2477 transcriptional regulator, Fur family, ev=5e-62, 82% identity YP_612924.1 PFAM: protein of unknown function DUF6, transmembrane: (0.00011); KEGG: sil:SPO2475 membrane protein, , ev=2e-88, 56% identity YP_612925.1 PFAM: major facilitator superfamily MFS_1: (3.6e-37); KEGG: jan:Jann_0119 major facilitator superfamily MFS_1, ev=4e-87, 41% identity YP_612926.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_612927.1 PFAM: GCN5-related N-acetyltransferase: (3.3e-05); KEGG: bja:blr1411 hypothetical protein, ev=7e-50, 51% identity YP_612928.1 PFAM: GCN5-related N-acetyltransferase: (1.6e-10); KEGG: sil:SPO2471 acetyltransferase, GNAT family, ev=4e-54, 69% identity YP_612929.1 PFAM: Inosine/uridine-preferring nucleoside hydrolase: (2.4e-121); KEGG: sil:SPO2470 inosine-uridine preferring nucleoside hydrolase, ev=1e-133, 76% identity YP_612930.1 KEGG: sil:SPO1104 hypothetical protein, ev=2e-09, 27% identity YP_612931.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_612932.1 KEGG: sil:SPO2468 amidohydrolase family protein, ev=1e-169, 75% identity; TIGRFAM: Peptidase M20D, amidohydrolase: (2.4e-142); PFAM: peptidase M20: (1.2e-59) peptidase dimerisation: (9.4e-07) YP_612933.1 catalyzes the formation of putrescine from agmatine YP_612934.1 TIGRFAM: agmatinase, : (1.3e-70); PFAM: Arginase/agmatinase/formiminoglutamase: (1.6e-59); KEGG: sil:SPO2464 agmatinase, ev=1e-148, 80% identity YP_612935.1 KEGG: sil:SPO2462 hypothetical protein, ev=1e-27, 66% identity YP_612936.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_612937.1 TIGRFAM: modification methylase, HemK family: (7.6e-52); PFAM: methyltransferase small: (9.1e-08); KEGG: sil:SPO2460 modification methylase, HemK family, ev=1e-113, 78% identity YP_612938.1 KEGG: sil:SPO2459 hypothetical protein, ev=2e-67, 59% identity YP_612939.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_612940.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_612941.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase: (0.00034); KEGG: sil:SPO2456 PPIC-type PPIASE domain, ev=1e-110, 52% identity YP_612942.1 PFAM: OstA-like protein: (0.0024) Organic solvent tolerance protein: (3.5e-17); KEGG: sil:SPO2455 organic solvent tolerance protein, , ev=0.0, 56% identity YP_612943.1 PFAM: permease YjgP/YjgQ: (4.3e-38); KEGG: sil:SPO2454 permease, YjgP/YjgQ family, ev=1e-138, 68% identity YP_612944.1 PFAM: permease YjgP/YjgQ: (7e-30); KEGG: sil:SPO3780 membrane protein, , ev=1e-90, 46% identity YP_612945.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_612946.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_612947.1 TIGRFAM: conserved hypothetical protein: (7.7e-53); KEGG: sil:SPO2449 hypothetical protein, ev=2e-53, 54% identity YP_612948.1 PFAM: multiple antibiotic resistance (MarC)-related proteins: (1e-65); KEGG: sil:SPO2448 membrane protein, MarC family, ev=5e-77, 71% identity YP_612949.1 PFAM: ABC transporter related: (2.2e-34); SMART: ATPase: (7.7e-08); KEGG: sil:SPO2446 ABC transporter, ATP-binding protein, ev=0.0, 78% identity YP_612950.1 KEGG: ret:RHE_CH01984 hypothetical protein, ev=4e-65, 38% identity YP_612951.1 TIGRFAM: Drug resistance transporter Bcr/CflA subfamily: (1.3e-31); PFAM: major facilitator superfamily MFS_1: (5.4e-48); KEGG: sil:SPO2445 drug resistance transporter, Bcr/CflA subfamily, ev=1e-153, 68% identity YP_612952.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_612953.1 KEGG: sil:SPO1621 TfoX domain protein, ev=4e-36, 67% identity YP_612954.1 PFAM: mannose-6-phosphate isomerase, type II: (6.8e-07) Nucleotidyl transferase: (0.00095) Cupin 2, conserved barrel: (0.0021); KEGG: rsp:RSP_0834 mannose-6-phosphate isomerase / mannose-1-phosphate guanylyltransferase, ev=5e-45, 30% identity YP_612955.1 PFAM: regulatory protein, LuxR: (6e-19) response regulator receiver: (1.4e-23); KEGG: sil:SPO0161 DNA-binding response regulator, LuxR family, ev=4e-67, 63% identity YP_612956.1 PFAM: oxidoreductase, molybdopterin binding: (0.00091); KEGG: sil:SPO0162 hypothetical protein, ev=8e-34, 51% identity YP_612957.1 PFAM: response regulator receiver: (7e-31) ATP-binding region, ATPase-like: (2.3e-39) histidine kinase A-like: (1e-21) Hpt: (6.2e-05) PAS fold-3: (0.00049) PAS fold-4: (0.00011) PAS fold: (4.3e-07); SMART: PAS: (2.2e-10); KEGG: sil:SPO0163 sensory box histidine kinase/response regulator, ev=1e-145, 41% identity YP_612958.1 PFAM: Sulfate transporter/antisigma-factor antagonist STAS: (1e-16); KEGG: vvy:VVA0580 anti-anti-sigma regulatory factor, ev=4e-33, 26% identity YP_612959.1 TIGRFAM: TIM-barrel protein, yjbN family: (6e-160); PFAM: dihydrouridine synthase, DuS: (2.1e-102); KEGG: sil:SPO2374 tRNA-dihydrouridine synthase A, ev=1e-143, 78% identity YP_612960.1 KEGG: sil:SPO2353 hypothetical protein, ev=4e-88, 59% identity YP_612961.1 PFAM: protein of unknown function DUF1289: (8.4e-21); KEGG: jan:Jann_2180 protein of unknown function DUF1289, ev=3e-23, 63% identity YP_612962.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_612963.1 KEGG: sil:SPO2349 cytochrome c-type biogenesis protein CycH, ev=1e-105, 52% identity YP_612964.1 TIGRFAM: sarcosine oxidase, beta subunit family: (1.4e-259); PFAM: FAD dependent oxidoreductase: (7.8e-79); KEGG: sil:SPO2348 sarcosine oxidase, beta subunit family, ev=0.0, 86% identity YP_612965.1 PFAM: Sarcosine oxidase, delta subunit, heterotetrameric: (1.5e-22); KEGG: sil:SPO2346 sarcosine oxidase, delta subunit family, ev=2e-51, 81% identity YP_612966.1 KEGG: sil:SPO2345 sarcosine oxidase, alpha subunit family, ev=0.0, 80% identity; TIGRFAM: sarcosine oxidase, alpha subunit family: (0); PFAM: glycine cleavage T protein (aminomethyl transferase): (5.5e-69) YP_612967.1 PFAM: Sarcosine oxidase, gamma subunit: (1.6e-18); KEGG: sil:SPO2344 sarcosine oxidase, gamma subunit family, ev=1e-47, 54% identity YP_612971.1 PFAM: manganese and iron superoxide dismutase: (8.6e-34); KEGG: sil:SPO2340 superoxide dismutase, Fe, ev=1e-107, 90% identity YP_612972.1 PFAM: GCN5-related N-acetyltransferase: (7.5e-09); KEGG: dde:Dde_3171 acetyltransferase, ev=1e-34, 44% identity YP_612973.1 PFAM: conserved hypothetical protein 730: (7e-51); KEGG: sil:SPO2337 decarboxylase family protein, ev=2e-73, 73% identity YP_612974.1 PFAM: Peptidoglycan-binding LysM: (2.1e-06); KEGG: sil:SPO2336 LysM domain protein, ev=3e-79, 35% identity YP_612975.1 PFAM: ABC transporter, transmembrane region: (6e-27) ABC transporter related: (5.6e-66); SMART: ATPase: (4e-20); KEGG: sil:SPO2335 ABC transporter, ATP-binding/permease protein, ev=0.0, 77% identity YP_612976.1 PFAM: Calcium-binding EF-hand: (0.0064); KEGG: jan:Jann_1891 hypothetical protein, ev=3e-07, 41% identity YP_612977.1 PFAM: regulatory protein, TetR: (7.3e-17); KEGG: sma:SAV4715 TetR-family transcriptional regulator, ev=9e-17, 35% identity YP_612978.1 PFAM: NAD-dependent epimerase/dehydratase: (0.0014) short-chain dehydrogenase/reductase SDR: (5.7e-16); KEGG: rso:RS03890 short chain dehydrogenase, ev=3e-65, 47% identity YP_612979.1 PFAM: histidine kinase, HAMP region: (4.5e-11) chemotaxis sensory transducer: (3.1e-88); KEGG: ccr:CC0430 methyl-accepting chemotaxis protein McpA, ev=1e-100, 48% identity YP_612982.1 PFAM: acriflavin resistance protein: (2.8e-24); KEGG: sil:SPO2332 transporter, AcrB/AcrD/AcrF family, ev=0.0, 73% identity YP_612983.1 PFAM: secretion protein HlyD: (0.00012); KEGG: sil:SPO2331 efflux transporter, RND family, MFP subunit, ev=1e-141, 64% identity YP_612984.1 KEGG: sil:SPO2330 hypothetical protein, ev=5e-57, 56% identity YP_612985.1 SMART: Pyrrolo-quinoline quinone: (0.057); KEGG: sil:SPO2329 PQQ enzyme repeat family protein, ev=1e-149, 61% identity YP_612986.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_612987.1 PFAM: fatty acid desaturase: (1.4e-18); KEGG: sil:SPO2327 fatty acid desaturase, ev=1e-146, 75% identity YP_612988.1 SMART: Helix-hairpin-helix DNA-binding, class 1: (0.017); KEGG: sil:SPO2326 hypothetical protein, ev=8e-26, 42% identity YP_612989.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_612990.1 TIGRFAM: preprotein translocase, YajC subunit: (5.6e-30); PFAM: YajC: (4.8e-31); KEGG: sil:SPO2322 preprotein translocase, YajC subunit, ev=5e-40, 86% identity YP_612991.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_612992.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_612993.1 PFAM: protein of unknown function DUF498: (4.1e-35); KEGG: sil:SPO2318 hypothetical protein, ev=1e-45, 75% identity YP_612994.1 ATP-binding protein; required for proper cytochrome c maturation YP_612995.1 TIGRFAM: heme exporter protein CcmB: (2.8e-116); PFAM: cytochrome c-type biogenesis protein CcmB: (2.5e-107); KEGG: sil:SPO2316 heme exporter protein CcmB, ev=3e-99, 84% identity YP_612996.1 TIGRFAM: heme exporter protein CcmC: (2.6e-113); PFAM: cytochrome c assembly protein: (9.3e-48); KEGG: rsp:RSP_1803 ABC heme exporter, inner membrane subunit CcmC, ev=1e-111, 78% identity YP_612997.1 PFAM: Heme exporter protein D (CcmD): (3.6e-10); KEGG: rsp:RSP_1804 heme exporter protein D, ev=9e-07, 51% identity YP_612998.1 TIGRFAM: periplasmic protein thiol: (1.2e-69); PFAM: Redoxin: (1.3e-15); KEGG: sil:SPO2314 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily, ev=4e-73, 71% identity YP_612999.1 PFAM: NAD-dependent epimerase/dehydratase: (8e-05) short-chain dehydrogenase/reductase SDR: (2e-19); KEGG: bur:Bcep18194_C7123 short-chain dehydrogenase/reductase SDR, ev=2e-33, 35% identity YP_613001.1 Catalyzes the conversion of citrate to isocitrate YP_613002.1 PFAM: protein of unknown function DUF1223: (1.9e-58); KEGG: sil:SPO2311 hypothetical protein, ev=3e-59, 48% identity YP_613003.1 PFAM: lipid A biosynthesis acyltransferase: (2.1e-25); KEGG: sil:SPO2310 lipid A biosynthesis lauroyl acyltransferase, , ev=1e-94, 56% identity YP_613004.1 PFAM: flagellar motor switch protein FliG: (2.8e-06); KEGG: sil:SPO2308 flagellar motor switch protein FliG, ev=1e-106, 60% identity YP_613005.1 PFAM: TPR repeat: (7.2e-05) Tetratricopeptide TPR_2: (6.9e-05); KEGG: sil:SPO2307 hypothetical protein, ev=4e-55, 59% identity YP_613006.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_613008.1 PFAM: OsmC-like protein: (1.4e-33); KEGG: sil:SPO2301 osmC-like family protein, ev=1e-179, 77% identity YP_613009.1 PFAM: NUDIX hydrolase: (0.00022); KEGG: xac:XAC1843 hypothetical protein, ev=4e-27, 44% identity YP_613010.1 PFAM: Endonuclease/exonuclease/phosphatase: (3.9e-06); KEGG: jan:Jann_1778 endonuclease/exonuclease/phosphatase, ev=6e-41, 35% identity YP_613011.1 PFAM: peptidase M24: (2.7e-06); KEGG: sil:SPO2299 metallopeptidase, family M24, ev=0.0, 88% identity YP_613012.1 KEGG: sil:SPO2298 hypothetical protein, ev=9e-79, 62% identity YP_613013.1 KEGG: sil:SPO2297 hypothetical protein, ev=2e-12, 24% identity YP_613014.1 KEGG: sil:SPO2296 hypothetical protein, ev=1e-108, 73% identity YP_613015.1 KEGG: rsp:RSP_3200 molecular chaperone, DnaK, ev=1e-111, 54% identity YP_613017.1 KEGG: sil:SPO2295 glutamine synthetase, type I, ev=0.0, 93% identity; TIGRFAM: glutamine synthetase, type I: (1.1e-280); PFAM: glutamine synthetase, catalytic region: (2.5e-166) glutamine synthetase, beta-Grasp: (6.6e-40) YP_613018.1 PFAM: nitrogen regulatory protein P-II: (3.9e-69); KEGG: sil:SPO2294 nitrogen regulatory protein P-II, ev=1e-53, 94% identity YP_613019.1 PFAM: protein of unknown function UPF0031: (2.4e-39) YjeF-related protein-like: (4.1e-45); KEGG: sil:SPO2293 YjeF family protein, ev=1e-172, 60% identity YP_613020.1 KEGG: sil:SPO2292 hypothetical protein, ev=6e-25, 42% identity YP_613021.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_613022.1 PFAM: histidine kinase, HAMP region: (6e-08) chemotaxis sensory transducer: (1.7e-79); KEGG: ret:RHE_CH03477 probable methyl-accepting chemotaxis protein, ev=3e-88, 32% identity YP_613023.1 PFAM: CheB methylesterase: (1.2e-20) MCP methyltransferase, CheR-type: (8.2e-58) ATP-binding region, ATPase-like: (1e-30) histidine kinase A-like: (1.1e-11) PAS fold-3: (5.2e-26); SMART: PAS: (0.0017) PAC motif: (3.1e-09); KEGG: ava:Ava_0314 signal transduction histidine kinase (STHK) with CheB and CheR activity, ev=1e-134, 29% identity YP_613024.1 PFAM: response regulator receiver: (0.00011); KEGG: lic:LIC12088 response regulator, ev=2e-08, 31% identity YP_613025.1 PFAM: ATP-binding region, ATPase-like: (5.8e-21) histidine kinase A-like: (0.00038); SMART: extracellular solute-binding protein, family 3: (2.3e-16); KEGG: ana:all2899 phytochrome-like protein, two-component sensor, ev=9e-33, 38% identity YP_613026.1 PFAM: response regulator receiver: (4.1e-23); KEGG: ret:RHE_CH00624 probable two-component sensor histidine kinase/response regulator hybrid protein, ev=5e-18, 41% identity YP_613027.1 KEGG: sil:SPO2289 hypothetical protein, ev=4e-79, 46% identity YP_613028.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_613030.1 TIGRFAM: GGDEF domain: (3.3e-26); PFAM: GGDEF: (1.5e-35); KEGG: rru:Rru_A3391 diguanylate cyclase (GGDEF domain), ev=8e-25, 34% identity YP_613031.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_613032.1 PFAM: Lytic transglycosylase, catalytic: (9.6e-05); KEGG: sil:SPO2284 transglycosylase SLT domain protein, ev=1e-59, 72% identity YP_613033.1 PFAM: flagellin-like: (1.4e-06); KEGG: bmb:BruAb2_1084 flagellin family protein, ev=2e-48, 40% identity YP_613034.1 PFAM: flagellin-like: (5.7e-06); KEGG: jan:Jann_4203 flagellin-like, ev=5e-48, 45% identity YP_613035.1 PFAM: flagellin-like: (1.2e-06); KEGG: ret:RHE_PE00392 flagellin C protein, ev=4e-46, 39% identity YP_613036.1 KEGG: ppr:PBPRB1724 hypothetical protein, ev=4e-09, 36% identity YP_613038.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_613039.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_613040.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_613041.1 KEGG: sil:SPO2280 hypothetical protein, ev=4e-24, 36% identity YP_613042.1 PFAM: YceI: (4e-49); KEGG: sil:SPO2279 hypothetical protein, ev=6e-77, 74% identity YP_613043.1 KEGG: mag:amb0186 ABC-type amino acid transport/signal transduction systems, ev=4e-20, 32% identity YP_613044.1 PFAM: YceI: (2.8e-11) cytochrome B561: (8.9e-33); KEGG: sil:SPO2277 cytochrome, , ev=1e-118, 54% identity YP_613045.1 TIGRFAM: malonyl CoA-acyl carrier protein transacylase: (5.7e-130); PFAM: acyl transferase region: (8.5e-16); KEGG: sil:SPO2276 malonyl CoA-acyl carrier protein transacylase, ev=1e-138, 84% identity YP_613046.1 TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase: (1.1e-146); PFAM: NAD-dependent epimerase/dehydratase: (0.0009) short-chain dehydrogenase/reductase SDR: (6.3e-46) Male sterility-like: (0.0027); KEGG: sil:SPO2275 3-oxoacyl-(acyl-carrier-protein) reductase, ev=1e-115, 84% identity YP_613047.1 carries the fatty acid chain in fatty acid biosynthesis YP_613048.1 PFAM: histidine biosynthesis: (1.5e-53); KEGG: sil:SPO2272 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, , ev=4e-92, 65% identity YP_613049.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_613050.1 PFAM: aminodeoxychorismate lyase: (1e-112); KEGG: sil:SPO2270 conserved hypothetical protein TIGR00247, ev=1e-161, 74% identity YP_613051.1 KEGG: sil:SPO2267 hypothetical protein, ev=2e-08, 39% identity YP_613052.1 PFAM: protein of unknown function DUF264: (9.5e-52); KEGG: sil:SPO2266 terminase, large subunit, , ev=1e-174, 73% identity YP_613053.1 TIGRFAM: Phage portal protein, HK97: (1.2e-64); PFAM: phage portal protein: (2e-89); KEGG: sil:SPO2264 portal protein, HK97 family, ev=1e-157, 70% identity YP_613054.1 KEGG: sil:SPO2263 hypothetical protein, ev=4e-17, 60% identity YP_613055.1 PFAM: peptidase U35, phage prohead HK97: (2e-52); KEGG: sil:SPO2262 phage prohead protease, HK97 family, ev=5e-54, 62% identity YP_613056.1 PFAM: phage major capsid protein, HK97: (1.4e-92); KEGG: sil:SPO2261 major capsid protein, HK97 family, ev=1e-170, 80% identity YP_613057.1 TIGRFAM: Phage conserved hypothetical protein, phiE125 gp8: (9.4e-50); KEGG: sil:SPO2260 hypothetical protein, ev=9e-50, 53% identity YP_613058.1 TIGRFAM: conserved hypothetical protein: (0.0012); KEGG: sil:SPO2259 head-tail adaptor, , ev=5e-29, 55% identity YP_613059.1 KEGG: sil:SPO2258 hypothetical protein, ev=3e-41, 64% identity YP_613060.1 TIGRFAM: Phage major tail protein, TP901-1: (9.2e-36); KEGG: sil:SPO2257 major tail protein, TP901-1 family, ev=3e-61, 83% identity YP_613061.1 KEGG: sil:SPO2256 hypothetical protein, ev=3e-30, 63% identity YP_613062.1 TIGRFAM: conserved hypothetical protein: (7e-19); KEGG: sil:SPO2255 hypothetical protein, ev=6e-14, 67% identity YP_613063.1 KEGG: jan:Jann_1642 phage-related minor tail protein-like, ev=1e-60, 56% identity YP_613064.1 TIGRFAM: conserved hypothetical protein: (9.6e-99); KEGG: sil:SPO2253 hypothetical protein, ev=2e-84, 70% identity YP_613065.1 TIGRFAM: Phage conserved hypothetical protein BR0599: (5.4e-129); KEGG: sil:SPO2252 hypothetical protein, ev=1e-113, 66% identity YP_613066.1 TIGRFAM: phage cell wall peptidase, NlpC/P60: (5.4e-71); PFAM: NLP/P60: (3.3e-06); KEGG: sil:SPO2251 hypothetical protein, ev=3e-46, 65% identity YP_613067.1 KEGG: sil:SPO2250 hypothetical protein, ev=0.0, 63% identity YP_613068.1 KEGG: sil:SPO2249 hypothetical protein, ev=1e-12, 43% identity YP_613069.1 PFAM: Cold-shock protein, DNA-binding: (2.5e-28); SMART: Cold shock protein: (2.4e-25); KEGG: rsp:RSP_0591 cold-shock protein, ev=9e-23, 72% identity YP_613070.1 KEGG: sil:SPO2247 serine O-acetyltransferase, ev=1e-129, 83% identity; TIGRFAM: serine O-acetyltransferase: (1.3e-96); PFAM: transferase hexapeptide repeat: (0.081) serine acetyltransferase-like: (2.5e-43) YP_613071.1 PFAM: protein of unknown function DUF1330: (8.2e-30); KEGG: mlo:mll3541 hypothetical protein, ev=2e-11, 41% identity YP_613072.1 KEGG: sil:SPO2242 pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase, ev=0.0, 83% identity; TIGRFAM: Dihydrolipoamide acetyltransferase, long form: (2.2e-209); PFAM: biotin/lipoyl attachment: (1.8e-23) catalytic domain of components of various dehydrogenase complexes: (5.8e-114) E3 binding: (6e-18) YP_613073.1 catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acetyltransferase within the complex. The E1 component of the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase(E2) and lipoamide dehydrogenase YP_613074.1 PFAM: dehydrogenase, E1 component: (1.4e-135); KEGG: jan:Jann_1691 pyruvate dehydrogenase (lipoamide), ev=1e-169, 84% identity YP_613076.1 PFAM: Septum formation initiator: (3.1e-10); KEGG: sil:SPO2239 hypothetical protein, ev=4e-33, 69% identity YP_613077.1 KEGG: rso:RSc0006 hypothetical protein, ev=5e-19, 50% identity YP_613078.1 PFAM: histidine kinase, HAMP region: (1.5e-10) chemotaxis sensory transducer: (3.2e-66); KEGG: sme:SMc01104 probable chemoreceptor (methyl-accepting chemotaxis) transmembrane protein, ev=9e-72, 40% identity YP_613079.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_613080.1 PFAM: peptidyl-prolyl cis-trans isomerase, cyclophilin type: (2e-21); KEGG: sil:SPO2234 peptidyl-prolyl cis-trans isomerase, cyclophilin-type, ev=3e-79, 86% identity YP_613081.1 PFAM: peptidyl-prolyl cis-trans isomerase, cyclophilin type: (4.8e-21); KEGG: sil:SPO2233 peptidyl-prolyl cis-trans isomerase, cyclophilin-type, ev=2e-68, 72% identity YP_613082.1 PFAM: Hemolysin-type calcium-binding region: (0.13); KEGG: sme:SMb21314 secreted calcium-binding protein, ev=6e-32, 39% identity YP_613083.1 PFAM: protein of unknown function DUF583: (2.4e-30); KEGG: sil:SPO2231 hypothetical protein, ev=3e-67, 79% identity YP_613084.1 PFAM: peptidase M23B: (6e-51); KEGG: sil:SPO2230 peptidase, M23/M37 family, ev=1e-179, 70% identity YP_613085.1 PFAM: protein of unknown function DUF455: (8e-83); KEGG: sil:SPO2229 hypothetical protein, ev=1e-124, 78% identity YP_613086.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen: (5.3e-12) Redoxin: (9.3e-22); KEGG: sil:SPO2228 AhpC/TSA family protein, ev=2e-67, 79% identity YP_613087.1 KEGG: sil:SPO2227 hypothetical protein, ev=0.0, 45% identity YP_613088.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_613089.1 PFAM: major facilitator superfamily MFS_1: (1e-28); KEGG: sil:SPO2225 membrane protein, , ev=1e-166, 70% identity YP_613090.1 PFAM: protein of unknown function DUF924: (1.9e-68); KEGG: sil:SPO2224 hypothetical protein, ev=1e-78, 71% identity YP_613091.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_613092.1 PFAM: major facilitator superfamily MFS_1: (3.5e-19); KEGG: sil:SPO3505 membrane protein, , ev=3e-85, 45% identity YP_613093.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_613095.1 PFAM: helix-turn-helix motif: (2.4e-07); KEGG: sil:SPO2216 DNA-binding protein, , ev=8e-71, 58% identity YP_613096.1 KEGG: sil:SPO2213 3-hydroxyisobutyrate dehydrogenase, ev=1e-138, 86% identity; TIGRFAM: 3-hydroxyisobutyrate dehydrogenase: (1.3e-142); PFAM: NADP oxidoreductase, coenzyme F420-dependent: (0.0011) 6-phosphogluconate dehydrogenase, NAD-binding: (2e-61) YP_613097.1 PFAM: Enoyl-CoA hydratase/isomerase: (2.8e-12); KEGG: sil:SPO2212 enoyl-CoA hydratase/isomerase family protein, ev=1e-144, 71% identity YP_613098.1 PFAM: acyl-CoA dehydrogenase-like: (2.7e-67) Acyl-CoA dehydrogenase, type 2-like: (2e-22); KEGG: sil:SPO2211 acyl-CoA dehydrogenase, ev=0.0, 90% identity YP_613099.1 PFAM: TPR repeat: (2.5e-05) Tetratricopeptide TPR_2: (0.0023); SMART: Tetratricopeptide region: (8.8e-07); KEGG: pmn:PMN2A_1232 TPR repeat, ev=1e-101, 38% identity YP_613100.1 PFAM: ErfK/YbiS/YcfS/YnhG: (1.7e-37); KEGG: sil:SPO2205 ErfK/YbiS/YcfS/YnhG family protein, ev=3e-88, 77% identity YP_613101.1 TIGRFAM: methylmalonate-semialdehyde dehydrogenase: (2e-255); PFAM: aldehyde dehydrogenase: (1.2e-176); KEGG: rsp:RSP_2962 methylmalonic acid semialdehyde dehydrogenase, ev=0.0, 76% identity YP_613102.1 PFAM: regulatory protein, LysR: (1.3e-14) LysR, substrate-binding: (2.4e-28); KEGG: sil:SPO2202 transcriptional regulator, LysR family, ev=1e-122, 74% identity YP_613103.1 PFAM: CBS: (1.5e-31); KEGG: sil:SPO2201 CBS domain protein, ev=5e-43, 62% identity YP_613104.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_613105.1 KEGG: sil:SPO2199 hypothetical protein, ev=5e-11, 63% identity YP_613106.1 KEGG: sil:SPO2198 glyceraldehyde-3-phosphate dehydrogenase, type I, ev=1e-167, 87% identity; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I: (4.1e-169); PFAM: glyceraldehyde 3-phosphate dehydrogenase: (5.5e-59) YP_613107.1 PFAM: protein of unknown function DUF808: (1.9e-153); KEGG: sil:SPO2197 hypothetical protein, ev=1e-107, 65% identity YP_613108.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_613109.1 KEGG: sil:SPO1866 hypothetical protein, ev=3e-37, 39% identity YP_613110.1 KEGG: sil:SPO1867 hypothetical protein, ev=6e-49, 76% identity YP_613111.1 TIGRFAM: Glutaredoxin-related protein: (1.1e-54); PFAM: glutaredoxin: (1.4e-29); KEGG: sil:SPO1868 glutaredoxin-related protein, ev=2e-58, 88% identity YP_613112.1 PFAM: BolA-like protein: (5.2e-09); KEGG: jan:Jann_2172 BolA-like protein, ev=4e-33, 87% identity YP_613113.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_613114.1 PFAM: regulatory protein, LysR: (1e-22) LysR, substrate-binding: (4.1e-33); KEGG: sil:SPO1872 transcriptional regulator, LysR family, ev=1e-136, 80% identity YP_613115.1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates YP_613116.1 PFAM: phospholipid/glycerol acyltransferase: (0.00044); KEGG: sil:SPO1874 acyltransferase domain protein, ev=1e-136, 78% identity YP_613117.1 KEGG: sil:SPO1875 glutamate racemase, ev=1e-125, 83% identity; TIGRFAM: Glutamate racemase: (1.2e-32); PFAM: Asp/Glu racemase: (5.4e-54) YP_613118.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_613119.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_613120.1 PFAM: protein of unknown function DUF847: (6.3e-72); KEGG: sil:SPO1878 hypothetical protein, ev=3e-74, 68% identity YP_613121.1 KEGG: rsp:RSP_6081 hypothetical protein, ev=3e-26, 47% identity YP_613122.1 TIGRFAM: cytochrome c-type biogenesis protein CcmF: (1.3e-213); PFAM: cytochrome c assembly protein: (3.6e-85); KEGG: sil:SPO1880 cytochrome c-type biogenesis protein CcmF, ev=0.0, 82% identity YP_613123.1 PFAM: cytochrome C biogenesis protein: (2.2e-55); KEGG: sil:SPO1881 cytochrome c biogenesis family protein, ev=5e-51, 71% identity YP_613124.1 KEGG: rpa:RPA2489 hypothetical protein, ev=3e-30, 42% identity YP_613125.1 PFAM: Enoyl-CoA hydratase/isomerase: (1.2e-60); KEGG: sil:SPO1882 enoyl-CoA hydratase/isomerase family protein, ev=1e-108, 76% identity YP_613126.1 PFAM: Hemolysin-type calcium-binding region: (0.66); KEGG: bja:bll7673 hypothetical protein, ev=5e-47, 44% identity YP_613127.1 KEGG: sil:SPO2157 citrate synthase I, ev=0.0, 86% identity; TIGRFAM: Citrate synthase I: (2.2e-277); PFAM: Citrate synthase: (2.1e-219) YP_613128.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_613129.1 PFAM: ComEC/Rec2-related protein: (5.2e-62); KEGG: sil:SPO2155 competence protein, ev=0.0, 53% identity YP_613130.1 Represses a number of genes involved in the response to DNA damage YP_613131.1 PFAM: molybdopterin binding domain: (8e-37) MoeA-like, domain I and II: (2.7e-56) MoeA-like, domain IV: (1.3e-15); KEGG: sil:SPO2153 molybdenum cofactor biosynthesis protein A, ev=1e-150, 70% identity YP_613132.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_613133.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_613134.1 TIGRFAM: uracil-DNA glycosylase: (1.3e-77); PFAM: Uracil-DNA glycosylase superfamily: (4.2e-56); KEGG: tcx:Tcr_0362 uracil-DNA glycosylase, ev=5e-49, 53% identity YP_613135.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_613136.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_613137.1 KEGG: sil:SPO2148 hypothetical protein, ev=1e-106, 47% identity YP_613138.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_613139.1 KEGG: sil:SPO2145 peptidyl-prolyl cis-trans isomerse D, ev=1e-178, 52% identity YP_613140.1 PFAM: aminotransferase, class I and II: (1.4e-35); KEGG: sil:SPO2144 aminotransferase, classes I and II, ev=1e-150, 67% identity YP_613141.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_613142.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_613143.1 KEGG: sil:SPO2141 pyridoxamine 5''-phosphate oxidase, , ev=5e-90, 77% identity; TIGRFAM: pyridoxamine 5'-phosphate oxidase: (4.9e-63); PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding: (1.8e-22) YP_613144.1 PFAM: Cold-shock protein, DNA-binding: (9.3e-09); SMART: Cold shock protein: (1.2e-08); KEGG: sil:SPO2140 cold shock DNA-binding domain protein, ev=2e-73, 77% identity YP_613145.1 PFAM: protein of unknown function DUF192: (1.7e-38); KEGG: sil:SPO2139 hypothetical protein, ev=1e-44, 52% identity YP_613146.1 Catalyzes the rate-limiting step in dNTP synthesis YP_613148.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_613149.1 TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase: (1.5e-214); PFAM: pyruvate carboxyltransferase: (8.3e-27) LeuA allosteric (dimerisation) domain: (1.1e-26); KEGG: sil:SPO2130 2-isopropylmalate synthase/homocitrate synthase family protein, ev=0.0, 83% identity YP_613150.1 KEGG: sil:SPO2129 hypothetical protein, ev=5e-82, 59% identity YP_613151.1 PFAM: major facilitator superfamily MFS_1: (3.9e-19); KEGG: sil:SPO2128 transporter, , ev=0.0, 80% identity YP_613152.1 PFAM: HhH-GPD: (2.8e-14); KEGG: sil:SPO2127 DNA-3-methyladenine glycosylase II, , ev=1e-93, 81% identity YP_613153.1 PFAM: phospholipase/Carboxylesterase: (4.4e-35); KEGG: sil:SPO2126 phospholipase/carboxylesterase family protein, ev=1e-105, 85% identity YP_613154.1 PFAM: regulatory proteins, AsnC/Lrp: (1.7e-06); KEGG: sme:SMc02504 transcription regulator protein, ev=6e-13, 34% identity YP_613155.1 PFAM: Cupin 2, conserved barrel: (0.0012); KEGG: nma:NMA0001 hypothetical protein, ev=1e-30, 62% identity YP_613156.1 TIGRFAM: Pseudouridine synthase, Rsu: (4.4e-86); PFAM: pseudouridine synthase: (1e-23); KEGG: sil:SPO2124 RNA pseudouridylate synthase, ev=1e-75, 71% identity YP_613157.1 PFAM: HNH endonuclease: (8.6e-09); SMART: HNH nuclease: (1.6e-14); KEGG: sil:SPO2123 HNH endonuclease family protein, ev=3e-98, 84% identity YP_613158.1 catalyzes the formation of L-proline from L-ornithine YP_613159.1 KEGG: sil:SPO2120 amidinotransferase family protein, ev=1e-124, 75% identity YP_613160.1 TIGRFAM: arginase: (7.6e-114); PFAM: Arginase/agmatinase/formiminoglutamase: (8.7e-97); KEGG: sil:SPO2119 arginase, ev=1e-126, 70% identity YP_613161.1 PFAM: regulatory proteins, AsnC/Lrp: (1.7e-10) Helix-turn-helix, type 11: (0.0027); KEGG: sil:SPO2118 transcriptional regulator, AsnC family, ev=4e-60, 85% identity YP_613162.1 PFAM: Disulphide bond formation protein DsbB: (1.7e-05); KEGG: sil:SPO2117 disulfide bond formation protein, DsbB family, ev=2e-56, 68% identity YP_613163.1 KEGG: sil:SPO2116 DedA family protein, ev=3e-85, 81% identity YP_613164.1 KEGG: atc:AGR_L_3494 phototransducer; methyl-accepting chemotaxis protein; Ptr, ev=1e-152, 49% identity; TIGRFAM: GGDEF domain: (9.5e-38); PFAM: GGDEF: (1.1e-49) histidine kinase, HAMP region: (2.7e-12); SMART: GAF: (8.2e-06) YP_613165.1 activates fatty acids by binding to coenzyme A YP_613166.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_613167.1 PFAM: OsmC-like protein: (1.7e-22); KEGG: son:SO3409 OsmC/Ohr family protein, ev=1e-26, 41% identity YP_613168.1 PFAM: glycine cleavage T protein (aminomethyl transferase): (2.4e-45); KEGG: sil:SPO1648 aminomethyl transferase family protein, ev=2e-89, 44% identity YP_613169.1 PFAM: regulatory proteins, AsnC/Lrp: (4.9e-17); KEGG: sme:SMb20425 transcriptional regulator protein, ev=7e-36, 47% identity YP_613170.1 TIGRFAM: TRAP transporter solute receptor, TAXI family: (3.7e-67); KEGG: jan:Jann_2331 TRAP transporter solute receptor, TAXI family, ev=1e-83, 46% identity YP_613171.1 KEGG: sil:SPO2183 hypothetical protein, ev=1e-124, 62% identity YP_613172.1 PFAM: protein of unknown function DUF214: (7.3e-09); KEGG: sil:SPO2182 permease, , ev=0.0, 49% identity YP_613173.1 PFAM: ABC transporter related: (4.7e-58); SMART: ATPase: (4.5e-17); KEGG: sil:SPO2181 ABC transporter, ATP-binding protein, ev=2e-64, 61% identity YP_613174.1 PFAM: Ion transport 2: (2e-08); KEGG: sil:SPO2179 hypothetical protein, ev=2e-35, 51% identity YP_613175.1 TIGRFAM: ribonuclease BN, : (1.1e-22); PFAM: ribonuclease BN: (1.6e-41); KEGG: sil:SPO1856 ribonuclease BN, , ev=1e-71, 54% identity YP_613177.1 PFAM: ribosomal RNA methyltransferase RrmJ/FtsJ: (1.4e-61); KEGG: sil:SPO1858 ribosomal RNA large subunit methyltransferase J, ev=1e-115, 87% identity YP_613178.1 PFAM: Ppx/GppA phosphatase: (1.7e-28); KEGG: sil:SPO1859 phosphatase, Ppx/GppA family, ev=0.0, 89% identity YP_613179.1 KEGG: sil:SPO1861 hypothetical protein, ev=3e-43, 84% identity YP_613180.1 KEGG: sil:SPO1862 metFprotein, homolog, ev=1e-144, 83% identity YP_613181.1 catalyzes the transfer of the N5-methyl group from (6S)-methyl tetrahydrofolate to the cobalt center of a corrinoid iron-sulfur protein YP_613182.1 KEGG: atc:AGR_L_1930 sugar ABC transporter (sugar-binding protein), ev=1e-135, 70% identity YP_613183.1 PFAM: ABC transporter related: (2e-21); SMART: ATPase: (2.1e-09); KEGG: atc:AGR_L_1931 simple sugar transport system ATP-binding protein, ev=1e-179, 64% identity YP_613184.1 PFAM: inner-membrane translocator: (3.7e-55); KEGG: atc:AGR_L_1933 ribose ABC transporter (permease), ev=1e-132, 74% identity YP_613185.1 PFAM: sugar-binding region: (8.9e-68); KEGG: atc:AGR_L_1935 transcriptional regulator, ev=1e-101, 58% identity YP_613186.1 PFAM: aldo/keto reductase: (2.9e-52); KEGG: ret:RHE_PB00074 probable aldoketo reductase protein, ev=1e-133, 69% identity YP_613187.1 PFAM: FAD dependent oxidoreductase: (1.8e-47); KEGG: atc:AGR_L_1938 glycerol-3-phosphate dehydrogenase, ev=1e-166, 54% identity YP_613188.1 PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase: (8.4e-69); KEGG: atc:AGR_L_1940 aldolase MTH579, ev=1e-131, 81% identity YP_613189.1 PFAM: carbohydrate kinase, FGGY: (9.5e-59); KEGG: atc:AGR_L_1942 L-xylulokinase, ev=1e-171, 58% identity YP_613190.1 PFAM: Antibiotic biosynthesis monooxygenase: (1.9e-17); KEGG: bld:BLi00471 YcnE, ev=1e-09, 41% identity YP_613191.1 PFAM: helix-turn-helix, AraC type: (1.3e-11); KEGG: sil:SPO1057 transcriptional regulator, AraC family, ev=1e-42, 32% identity YP_613193.1 KEGG: reu:Reut_A3273 (acyl-carrier protein) phosphodiesterase, ev=5e-08, 32% identity YP_613194.1 KEGG: sil:SPO1992 hypothetical protein, ev=1e-76, 57% identity YP_613195.1 fusion of ribosomal protein L21 and COG3743 YP_613196.1 involved in the peptidyltransferase reaction during translation YP_613197.1 PFAM: GCN5-related N-acetyltransferase: (5.1e-06); KEGG: sil:SPO1987 acetyltransferase, GNAT family, ev=2e-73, 73% identity YP_613198.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_613199.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_613200.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_613201.1 KEGG: sil:SPO1983 hypothetical protein, ev=4e-54, 51% identity YP_613202.1 KEGG: sil:SPO1982 hypothetical protein, ev=8e-24, 83% identity YP_613203.1 KEGG: sil:SPO1980 hypothetical protein, ev=1e-100, 70% identity YP_613204.1 PFAM: phospholipid/glycerol acyltransferase: (3.2e-21); KEGG: sil:SPO1979 acyltransferase, , ev=1e-104, 68% identity YP_613205.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_613206.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_613207.1 PFAM: regulatory protein, LuxR: (8.9e-09) Autoinducer-binding: (5.8e-07) Bacterio-opsin activator, HTH: (0.0031) Sigma-70, region 4 type 2: (6.3e-07); KEGG: sil:SPO1974 autoinducer-binding transcriptional regulator, LuxR family, ev=1e-91, 65% identity YP_613209.1 PFAM: Enoyl-CoA hydratase/isomerase: (6.4e-08); KEGG: nfa:nfa21600 enoyl-CoA hydratase/isomerase family protein, ev=2e-11, 30% identity YP_613210.1 PFAM: response regulator receiver: (1.3e-13); KEGG: cps:CPS_3951 response regulator, ev=1e-25, 42% identity YP_613211.1 PFAM: ATP-binding region, ATPase-like: (5.3e-26) histidine kinase, HAMP region: (8.7e-06) histidine kinase A-like: (4.9e-11) PAS fold-4: (4.5e-06) PAS fold: (3.9e-05); SMART: PAS: (2.4e-06); KEGG: rba:RB9418 signal-transducing histidine kinase, ev=1e-44, 37% identity YP_613212.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.068); PFAM: protein of unknown function DUF882: (5.4e-48) Peptidase M15A: (8.3e-05); KEGG: sil:SPO1928 Tat (twin-arginine translocation) pathway signal sequence domain protein, ev=4e-86, 82% identity YP_613213.1 PFAM: Peptidoglycan-binding domain 1: (1.7e-17); KEGG: sil:SPO1929 peptidoglycan binding protein, , ev=1e-180, 59% identity YP_613214.1 TIGRFAM: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase: (3.9e-85); KEGG: sil:SPO1930 UDP-3-O-3-hydroxymyristoyl glucosamine N-acyltransferase, ev=1e-153, 74% identity YP_613215.1 PFAM: phosphopantetheine-binding: (4.8e-09); KEGG: sil:SPO1931 acyl carrier protein, , ev=1e-33, 86% identity YP_613216.1 PFAM: beta-ketoacyl synthase: (1.2e-52); KEGG: sil:SPO1932 beta-ketoacyl synthase family protein, ev=0.0, 90% identity YP_613217.1 PFAM: Invasion associated locus B: (1.3e-19); KEGG: sil:SPO1933 invasion associated family protein, ev=1e-67, 62% identity YP_613218.1 PFAM: protein of unknown function DUF853, NPT hydrolase : (1.2e-295); KEGG: sil:SPO1934 hypothetical protein, ev=0.0, 76% identity YP_613219.1 KEGG: sil:SPO2039 inosine-5'-monophosphate dehydrogenase, ev=0.0, 86% identity; TIGRFAM: inosine-5'-monophosphate dehydrogenase: (3e-254); PFAM: CBS: (1.7e-22) IMP dehydrogenase/GMP reductase: (1.1e-228) YP_613220.1 PFAM: L-carnitine dehydratase/bile acid-inducible protein F: (6.6e-78); KEGG: sil:SPO2040 CaiB/BaiF family protein, ev=1e-176, 79% identity YP_613221.1 PFAM: ferredoxin: (0.0056); KEGG: sil:SPO2041 iron-sulfur cluster-binding protein, ev=0.0, 84% identity YP_613222.1 PFAM: Fmu (Sun): (8.2e-13); KEGG: sil:SPO2037 NOL1/NOP2/sun family protein, ev=1e-121, 58% identity YP_613223.1 TIGRFAM: PAS: (7.2e-06); PFAM: response regulator receiver: (5.7e-17) ATP-binding region, ATPase-like: (6e-36) histidine kinase A-like: (2.7e-11); KEGG: sil:SPO2036 sensory box sensor histidine kianse/response regulator, ev=0.0, 64% identity YP_613224.1 KEGG: sil:SPO2035 hypothetical protein, ev=1e-62, 58% identity YP_613225.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_613226.1 KEGG: rsp:RSP_3140 hypothetical protein, ev=5e-56, 59% identity YP_613227.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_613228.1 PFAM: protein of unknown function DUF1330: (8.8e-41); KEGG: sil:SPO2032 hypothetical protein, ev=2e-43, 91% identity YP_613229.1 PFAM: glutamine amidotransferase, class-II: (0.00099); KEGG: rsp:RSP_0449 glutamine amidotransferase, ev=2e-94, 66% identity YP_613230.1 TIGRFAM: Small GTP-binding protein domain: (1.5e-22) GTP-binding protein TypA: (0); PFAM: elongation factor G-like: (1.3e-23) protein synthesis factor, GTP-binding: (1.7e-72) elongation factor Tu, domain 2: (3e-08); KEGG: sil:SPO2031 GTP-binding protein TypA, ev=0.0, 90% identity YP_613231.1 PFAM: small multidrug resistance protein: (2.7e-36); KEGG: sil:SPO2030 multidrug resistance efflux protein, SMR family, ev=1e-40, 74% identity YP_613232.1 KEGG: sil:SPO2028 HD domain protein, ev=1e-123, 58% identity YP_613233.1 KEGG: sil:SPO2027 hypothetical protein, ev=9e-18, 62% identity YP_613234.1 KEGG: sil:SPO2026 hypothetical protein, ev=1e-120, 94% identity YP_613235.1 PFAM: protein of unknown function UPF0074: (1.8e-40); KEGG: sil:SPO2025 iron-sulfur cluster assembly transcription factor IscR, , ev=2e-71, 88% identity YP_613236.1 PFAM: aminotransferase, class V: (8.6e-29); KEGG: rsp:RSP_0442 aminotransferase, ev=1e-131, 67% identity YP_613237.1 with SufCD activates cysteine desulfurase SufS YP_613238.1 PFAM: protein of unknown function DUF74: (5.9e-61); KEGG: sil:SPO2021 hypothetical protein, ev=5e-43, 90% identity YP_613239.1 TIGRFAM: Methyltransferase FkbM: (1.9e-26); KEGG: jan:Jann_2362 methyltransferase FkbM, ev=6e-56, 49% identity YP_613240.1 KEGG: sil:SPO2018 FeS assembly ATPase SufC, ev=1e-127, 92% identity; TIGRFAM: FeS assembly ATPase SufC: (1.5e-163); PFAM: ABC transporter related: (9.6e-32); SMART: ATPase: (1.4e-06) YP_613241.1 PFAM: SufBD: (6.7e-27); KEGG: sil:SPO2017 FeS assembly protein SufD, ev=0.0, 79% identity YP_613242.1 KEGG: sil:SPO2016 hypothetical protein, ev=4e-56, 66% identity YP_613243.1 KEGG: sil:SPO2015 hypothetical protein, ev=6e-19, 31% identity YP_613244.1 TIGRFAM: cysteine desulfurases, SufS subfamily: (6.6e-224); PFAM: aminotransferase, class V: (4.6e-167); KEGG: sil:SPO2014 cysteine desulfurase SufS, ev=0.0, 84% identity YP_613245.1 PFAM: UspA: (5.5e-19); KEGG: sil:SPO2185 universal stress protein family protein, ev=1e-26, 45% identity YP_613246.1 TIGRFAM: TRAP transporter, 4TM/12TM fusion protein: (5.1e-224); PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (1.7e-65); KEGG: dps:DP0744 hypothetical protein, ev=0.0, 53% identity YP_613247.1 TIGRFAM: TRAP transporter solute receptor, TAXI family: (7.5e-97); KEGG: sil:SPO2187 TRAP transporter solute receptor, TAXI family, ev=1e-110, 62% identity YP_613248.1 PFAM: sugar isomerase (SIS): (5.7e-06); KEGG: sil:SPO1591 SIS domain protein, ev=1e-36, 29% identity YP_613249.1 PFAM: FAD dependent oxidoreductase: (1.5e-93) glycine cleavage T protein (aminomethyl transferase): (7.6e-63); KEGG: sil:SPOA0311 FAD dependent oxidoreductase/aminomethyl transferase, ev=0.0, 48% identity YP_613250.1 PFAM: acyl-CoA dehydrogenase-like: (6e-24) Acyl-CoA dehydrogenase, type 2-like: (0.0012); KEGG: sil:SPO1955 glutaryl-CoA dehydrogenase, ev=0.0, 89% identity YP_613251.1 PFAM: regulatory protein, LysR: (5.5e-17) LysR, substrate-binding: (1.7e-38); KEGG: sil:SPO1954 transcriptional regulator, LysR family, ev=1e-111, 65% identity YP_613252.1 TIGRFAM: Phosphate regulon transcriptional regulatory protein phoB: (1.6e-151); PFAM: response regulator receiver: (8.3e-39) transcriptional regulatory protein-like: (3.6e-26); KEGG: sil:SPO1953 phosphate regulon transcriptional regulatory protein PhoB, ev=1e-118, 90% identity YP_613253.1 PFAM: PhoU: (1.2e-29); KEGG: sil:SPO1952 phosphate transport system regulatory protein PhoU, ev=1e-93, 74% identity YP_613254.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_613255.1 TIGRFAM: Phosphate transport system permease protein 2: (9.5e-66); PFAM: binding-protein-dependent transport systems inner membrane component: (7.9e-16); KEGG: sil:SPO1950 phosphate ABC transporter, permease protein, ev=0.0, 80% identity YP_613256.1 TIGRFAM: Phosphate ABC transporter, permease protein PstC: (1.1e-103); PFAM: binding-protein-dependent transport systems inner membrane component: (1.2e-17); KEGG: sil:SPO1949 phosphate ABC transporter, permease protein, ev=0.0, 79% identity YP_613257.1 KEGG: sil:SPO1948 phosphate ABC transporter, periplasmic phosphate-binding protein, ev=1e-179, 90% identity YP_613258.1 PFAM: ATP-binding region, ATPase-like: (9.3e-41) histidine kinase A-like: (2e-22); KEGG: sil:SPO1947 phosphate regulon sensor histidine kinase, , ev=1e-129, 68% identity YP_613259.1 PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes: (4e-99) aromatic amino acid beta-eliminating lyase/threonine aldolase: (0.0045); KEGG: rsp:RSP_2917 cystathionine gamma-synthase beta-lyase, ev=1e-154, 69% identity YP_613260.1 PFAM: transferase hexapeptide repeat: (0.044); KEGG: sil:SPO1946 bacterial transferase family protein, ev=5e-82, 84% identity YP_613261.1 Essential for recycling GMP and indirectly, cGMP YP_613262.1 TIGRFAM: conserved hypothetical protein: (9.1e-72); PFAM: YicC-like-like: (1.5e-31) Domain of unknown function DUF1732: (3.4e-55); KEGG: sil:SPO1944 YicC family protein, ev=9e-94, 61% identity YP_613263.1 KEGG: sil:SPO1943 hypothetical protein, ev=1e-55, 48% identity YP_613264.1 KEGG: sil:SPO1942 3-deoxy-7-phosphoheptulonate synthase, ev=0.0, 84% identity; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase: (8e-294); PFAM: DAHP synthetase, class II: (8.2e-257) YP_613265.1 PFAM: helix-turn-helix, AraC type: (1.1e-06) ThiJ/PfpI: (1.4e-09); KEGG: sil:SPO1941 transcriptional regulator, AraC family, ev=1e-149, 81% identity YP_613266.1 PFAM: glucose sorbosone dehydrogenase: (4e-53); KEGG: sil:SPO1940 hypothetical protein, ev=1e-128, 61% identity YP_613267.1 PFAM: Extracellular ligand-binding receptor: (1.5e-22); KEGG: jan:Jann_2165 extracellular ligand-binding receptor, ev=1e-142, 63% identity YP_613268.1 PFAM: ABC transporter related: (3.9e-47); SMART: ATPase: (6.3e-10); KEGG: sil:SPO1938 branched-chain amino acid ABC transporter, ATP-binding protein, ev=1e-131, 88% identity YP_613269.1 PFAM: ABC transporter related: (8.2e-47); SMART: ATPase: (8.1e-12); KEGG: sil:SPO1937 branched-chain amino acid ABC transporter, ATP-binding protein, ev=1e-117, 90% identity YP_613270.1 PFAM: inner-membrane translocator: (2.9e-34); KEGG: sil:SPO1936 branched-chain amino acid ABC transporter, permease protein, ev=1e-155, 80% identity YP_613271.1 PFAM: inner-membrane translocator: (3.6e-08); KEGG: sil:SPO1935 branched-chain amino acid ABC transporter, permease protein, ev=0.0, 72% identity YP_613272.1 KEGG: rpb:RPB_3781 hypothetical protein, ev=5e-10, 33% identity YP_613273.1 PFAM: phage late control D: (6.8e-98); KEGG: xfa:XF2479 hypothetical protein, ev=5e-64, 38% identity YP_613274.1 PFAM: phage tail X: (3.5e-15); KEGG: sbo:SBO_0763 probable phage tail protein, ev=1e-08, 45% identity YP_613275.1 PFAM: phage P2 GpU: (6.3e-49); KEGG: syf:Synpcc7942_0751 hypothetical protein, ev=2e-28, 51% identity YP_613276.1 KEGG: nar:Saro_2736 hypothetical protein, ev=9e-28, 38% identity YP_613277.1 KEGG: xft:PD1092 hypothetical protein, ev=1e-07, 37% identity YP_613278.1 PFAM: phage major tail tube protein: (6.2e-47); KEGG: xfa:XF2484 hypothetical protein, ev=3e-36, 45% identity YP_613279.1 PFAM: phage tail sheath protein: (2.7e-129); KEGG: xft:PD1094 phage-related contractile tail sheath protein, ev=1e-132, 59% identity YP_613282.1 KEGG: rba:RB7745 serine protease homologue- secreted serine protease, ev=1e-29, 36% identity YP_613284.1 KEGG: ecc:c0968 probable variable tail fibre protein, ev=8e-31, 37% identity YP_613285.1 TIGRFAM: Phage tail protein I: (4.5e-37); KEGG: pfl:PFL_2006 tail protein I, ev=3e-31, 43% identity YP_613286.1 PFAM: Baseplate J-like protein: (2.3e-74); KEGG: pae:PA0618 probable bacteriophage protein, ev=9e-73, 48% identity YP_613287.1 PFAM: GPW/gp25: (1.3e-45); KEGG: syf:Synpcc7942_0739 hypothetical protein, ev=2e-25, 51% identity YP_613288.1 PFAM: PAAR: (0.003); KEGG: eca:ECA3426 phospholipase, ev=2e-19, 47% identity YP_613289.1 PFAM: phage baseplate assembly protein V: (1.9e-13); KEGG: eca:ECA2612 baseplate assembly protein V, ev=5e-13, 41% identity YP_613290.1 KEGG: xfa:XF2493 hypothetical protein, ev=1e-28, 39% identity YP_613291.1 KEGG: wol:WD0644 prophage LambdaW5, minor tail protein Z, , ev=3e-12, 32% identity YP_613292.1 KEGG: xft:PD1104 hypothetical protein, ev=3e-17, 44% identity YP_613294.1 PFAM: peptidase U35, phage prohead HK97: (6.5e-14) phage major capsid protein, HK97: (0.0041); KEGG: xfa:XF2497 hypothetical protein, ev=1e-128, 42% identity YP_613295.1 PFAM: phage portal protein, lambda: (1.8e-62); KEGG: xft:PD1107 phage-related portal protein, ev=7e-99, 38% identity YP_613296.1 KEGG: xfa:XF2499 hypothetical protein, ev=3e-27, 40% identity YP_613297.1 PFAM: phage terminase GpA: (2.5e-216); KEGG: xft:PD1109 phage-related terminase large subunit, ev=0.0, 56% identity YP_613298.1 PFAM: phage DNA packaging Nu1: (2.7e-27); KEGG: xfa:XF2501 hypothetical protein, ev=6e-42, 49% identity YP_613300.1 PFAM: glycoside hydrolase, family 24: (3.9e-18); KEGG: xfa:XF0513 phage-related endolysin, ev=2e-27, 46% identity YP_613303.1 KEGG: psb:Psyr_0103 hypothetical protein, ev=5e-10, 34% identity YP_613305.1 KEGG: xft:PD1114 hypothetical protein, ev=5e-07, 39% identity YP_613306.1 KEGG: bte:BTH_II1034 GP72, ev=5e-08, 42% identity YP_613308.1 KEGG: jan:Jann_2635 hypothetical protein, ev=1e-28, 72% identity YP_613315.1 PFAM: peptidase S24, S26A and S26B: (0.018); KEGG: rsp:RSP_3771 hypothetical protein, ev=1e-35, 40% identity YP_613316.1 KEGG: lma:LmjF34.0690 hypothetical protein, conserved, ev=4e-08, 33% identity YP_613317.1 PFAM: Ankyrin: (9.4e-05); KEGG: bta:528403 similar to ankyrin repeat and FYVE domain containing 1 isoform 1, ev=4e-13, 27% identity YP_613319.1 KEGG: psp:PSPPH_A0091 hypothetical protein, ev=1e-102, 45% identity YP_613322.1 KEGG: rsp:RSP_3624 hypothetical protein, ev=5e-64, 51% identity YP_613323.1 PFAM: phage integrase: (3e-06); KEGG: mag:amb2709 integrase, ev=5e-35, 33% identity YP_613324.1 PFAM: thioesterase superfamily: (0.00047); KEGG: jan:Jann_1972 thioesterase superfamily, ev=2e-24, 38% identity YP_613325.1 TIGRFAM: 6-phosphogluconolactonase: (7.2e-34); KEGG: sil:SPO2047 6-phosphogluconolactonase, ev=7e-68, 59% identity YP_613326.1 PFAM: Usg-like: (5.9e-50); KEGG: sil:SPO2050 Usg, , ev=2e-37, 78% identity YP_613327.1 negatively supercoils closed circular double-stranded DNA YP_613328.1 KEGG: sil:SPO2052 hypothetical protein, ev=2e-49, 77% identity YP_613329.1 PFAM: peptidase M32, carboxypeptidase Taq metallopeptidase: (2.1e-114); KEGG: sil:SPO2053 thermostable carboxypeptidase, ev=0.0, 71% identity YP_613330.1 PFAM: cytochrome oxidase assembly: (4.2e-46); KEGG: sil:SPO2054 cytochrome c oxidase assembly protein, ev=1e-167, 78% identity YP_613331.1 TIGRFAM: RNA methyltransferase TrmH, group 1: (1.4e-42); PFAM: tRNA/rRNA methyltransferase (SpoU): (8.9e-28); KEGG: sil:SPO2055 RNA methyltransferase, TrmH family, group 1, ev=1e-107, 77% identity YP_613332.1 PFAM: thiamine monophosphate synthase: (1e-13); KEGG: sil:SPO2056 thiamine-phosphate pyrophosphorylase, , ev=3e-82, 70% identity YP_613333.1 PFAM: PfkB: (3.5e-09); KEGG: sil:SPO2060 kinase, PfkB family, ev=1e-125, 77% identity YP_613334.1 PFAM: Indigoidine synthase A like protein: (6.7e-172); KEGG: sil:SPO2061 indigoidine synthase A family protein, ev=1e-127, 79% identity YP_613335.1 PFAM: protein of unknown function DUF502: (1.1e-55); KEGG: sil:SPO2062 hypothetical protein, ev=1e-100, 80% identity YP_613336.1 PFAM: Patatin: (3.1e-08); KEGG: sil:SPO2064 phospholipase, patatin-like family, ev=1e-136, 68% identity YP_613337.1 TIGRFAM: 3-hydroxybutyrate dehydrogenase: (2.1e-160); PFAM: short-chain dehydrogenase/reductase SDR: (3.3e-33); KEGG: sil:SPO2065 D-beta-hydroxybutyrate dehydrogenase, ev=1e-125, 84% identity YP_613338.1 PFAM: extracellular solute-binding protein, family 5: (7.3e-55); KEGG: sil:SPO2066 ABC transporter, periplasmic substrate-binding protein, ev=0.0, 66% identity YP_613340.1 PFAM: helix-turn-helix motif: (6e-14) Cupin 2, conserved barrel: (2.1e-07); KEGG: sil:SPO2068 DNA-binding protein, , ev=4e-96, 83% identity YP_613341.1 PFAM: AMP-dependent synthetase and ligase: (2.9e-89); KEGG: sil:SPO2069 benzoate-coenzyme A ligase, , ev=1e-172, 58% identity YP_613342.1 PFAM: DSBA oxidoreductase: (7.5e-43); KEGG: sil:SPO2070 DSBA-like thioredoxin family protein, ev=1e-88, 70% identity YP_613343.1 PFAM: major facilitator superfamily MFS_1: (8e-40); KEGG: sil:SPO2071 drug resistance transporter, Bcr/CflA subfamily, ev=1e-150, 67% identity YP_613344.1 TIGRFAM: transcription-repair coupling factor: (0); PFAM: helicase-like: (1.8e-17) transcription factor CarD: (1.9e-42) TRCF: (1e-44) type III restriction enzyme, res subunit: (8.4e-07) DEAD/DEAH box helicase-like: (4.2e-34); KEGG: sil:SPO2074 transcription-repair coupling factor, ev=0.0, 86% identity YP_613345.1 KEGG: sil:SPO2075 hypothetical protein, ev=6e-54, 58% identity YP_613346.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_613347.1 KEGG: sil:SPO2077 twin-arginine translocation pathway signal sequence domain protein, , ev=9e-73, 70% identity YP_613348.1 PFAM: 6-phosphogluconate dehydrogenase, NAD-binding: (3.4e-77); KEGG: sil:SPO0792 6-phosphogluconate dehydrogenase domain protein, ev=1e-137, 82% identity YP_613349.1 PFAM: peptidase S45, penicillin amidase: (1e-122); KEGG: sil:SPO2078 penicillin amidase family protein, ev=0.0, 75% identity YP_613350.1 PFAM: GTP-binding protein, HSR1-related: (5e-38); KEGG: sil:SPO2080 GTP-binding protein HflX, ev=0.0, 80% identity YP_613351.1 Stimulates the elongation of poly(A) tails YP_613352.1 PFAM: cation transporter: (2.5e-09); KEGG: sil:SPO2082 trk system potassium uptake protein TrkH, ev=0.0, 61% identity YP_613353.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_613354.1 PFAM: response regulator receiver: (1.9e-35) sigma-54 factor, interaction region: (3.8e-92) helix-turn-helix, Fis-type: (1.3e-09); SMART: ATPase: (2.4e-12); KEGG: sil:SPO2085 nitrogen assimilation regulatory protein NtrX, ev=0.0, 81% identity YP_613355.1 PFAM: ATP-binding region, ATPase-like: (1e-28) histidine kinase, HAMP region: (9.4e-19) histidine kinase A-like: (1.6e-12) PAS fold: (2.3e-06); KEGG: sil:SPO2086 nitrogen regulation protein NtrY, ev=0.0, 74% identity YP_613356.1 PFAM: response regulator receiver: (4.7e-39) sigma-54 factor, interaction region: (1.1e-40) helix-turn-helix, Fis-type: (1.6e-14); SMART: ATPase: (6.6e-08); KEGG: sil:SPO2087 nitrogen regulation protein NtrC, ev=0.0, 74% identity YP_613357.1 PFAM: ATP-binding region, ATPase-like: (4.5e-32) histidine kinase A-like: (5.2e-12); KEGG: sil:SPO2088 nitrogen regulation protein NtrB, ev=1e-155, 77% identity YP_613358.1 TIGRFAM: Dihydrouridine synthase TIM-barrel protein nifR3: (1.4e-125); PFAM: dihydrouridine synthase, DuS: (7.1e-130); KEGG: sil:SPO2089 tRNA-dihydrouridine synthase, , ev=1e-141, 76% identity YP_613359.1 TIGRFAM: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: (4.5e-74); PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase: (4.5e-76) MECDP-synthase: (4.1e-74); KEGG: sil:SPO2090 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/ 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ev=1e-151, 69% identity YP_613360.1 PFAM: phosphatidylglycerophosphatase A: (5.1e-30); KEGG: sil:SPO2091 phosphatidylglycerophosphatase, , ev=3e-65, 68% identity YP_613361.1 PFAM: CinA-like: (1.2e-63); KEGG: sil:SPO2092 competence/damage-inducible protein CinA domain protein, ev=5e-51, 65% identity YP_613362.1 PFAM: cyclase/dehydrase: (5e-38); KEGG: sil:SPO2096 aromatic-rich family protein, ev=2e-66, 80% identity YP_613363.1 KEGG: sil:SPO2097 hypoxanthine phosphoribosyltransferase, ev=6e-83, 88% identity; TIGRFAM: hypoxanthine phosphoribosyltransferase: (1.3e-90); PFAM: phosphoribosyltransferase: (1.1e-33) YP_613365.1 TIGRFAM: Peptidase M20D, amidohydrolase: (2.2e-40); PFAM: peptidase M20: (5.7e-38) peptidase dimerisation: (0.0023); KEGG: sil:SPO2101 amidohydrolase family protein, ev=1e-137, 62% identity YP_613366.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_613367.1 KEGG: sil:SPO2106 hypothetical protein, ev=3e-69, 43% identity YP_613368.1 KEGG: sil:SPO2107 hypothetical protein, ev=7e-12, 41% identity YP_613369.1 PFAM: trimethylamine methyltransferase: (2e-275); KEGG: sil:SPO2108 trimethylamine methyltransferase family protein, ev=0.0, 84% identity YP_613370.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_613371.1 PFAM: protein of unknown function DUF6, transmembrane: (1.2e-08); KEGG: sil:SPO2110 membrane protein, , ev=2e-97, 62% identity YP_613372.1 PFAM: membrane protein involved in aromatic hydrocarbon degradation: (4.1e-07); KEGG: rsp:RSP_0007 outer membrane protein, ev=1e-66, 39% identity YP_613373.1 KEGG: sil:SPO2113 hypothetical protein, ev=1e-114, 71% identity YP_613374.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_613375.1 PFAM: alpha/beta hydrolase fold: (1.9e-12); KEGG: sil:SPO1728 esterase, , ev=9e-87, 52% identity YP_613376.1 PFAM: protein of unknown function DUF344: (2.7e-137); KEGG: sil:SPO1727 polyphosphate kinase 2, , ev=1e-115, 69% identity YP_613377.1 PFAM: regulatory protein, TetR: (5e-13); KEGG: sil:SPO3896 transcriptional regulator, TetR family, ev=3e-89, 79% identity YP_613378.1 PFAM: histidine kinase, HAMP region: (2.6e-06) chemotaxis sensory transducer: (4.9e-87) Nitrate and nitrite sensing: (7.3e-30); KEGG: ccr:CC0430 methyl-accepting chemotaxis protein McpA, ev=6e-92, 42% identity YP_613379.1 forms a direct contact with the tRNA during translation YP_613380.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_613381.1 PFAM: regulatory protein GntR, HTH: (4.7e-18) aminotransferase, class I and II: (5.3e-07); KEGG: sil:SPO1690 transcriptional regulator, GntR family, ev=0.0, 67% identity YP_613383.1 PFAM: S-adenosylmethionine decarboxylase related: (1.2e-42); KEGG: tcx:Tcr_0272 S-adenosylmethionine decarboxylase related, ev=3e-35, 61% identity YP_613384.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_613385.1 TIGRFAM: Phenylacetic acid degradation-related protein: (1.1e-07); PFAM: thioesterase superfamily: (5.3e-11); KEGG: sil:SPO1688 thioesterase family protein, ev=2e-49, 69% identity YP_613386.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_613387.1 PFAM: Methyltransferase type 11: (1.3e-07) Methyltransferase type 12: (2.3e-06); KEGG: jan:Jann_2499 methyltransferase type 12, ev=3e-36, 47% identity YP_613388.1 PFAM: glutamyl-tRNA synthetase, class Ic: (1.9e-24); KEGG: rsp:RSP_2628 glutamyl-/glutaminyl-tRNA synthetase, ev=9e-96, 64% identity YP_613389.1 PFAM: phosphoribosyl-AMP cyclohydrolase: (9.7e-52); KEGG: sil:SPO1684 phosphoribosyl-AMP cyclohydrolase, ev=3e-51, 77% identity YP_613390.1 KEGG: sil:SPO1683 hypothetical protein, ev=4e-62, 78% identity YP_613392.1 catalyzes branch migration in Holliday junction intermediates YP_613393.1 KEGG: sil:SPO1680 DNA ligase, NAD-dependent, ev=0.0, 75% identity; TIGRFAM: DNA ligase, NAD-dependent: (4.1e-283); PFAM: BRCT: (1.9e-17) NAD-dependent DNA ligase: (2.1e-140) zinc-finger, NAD-dependent DNA ligase C4-type: (2.5e-10) NAD-dependent DNA ligase, OB-fold: (1.9e-38) YP_613394.1 PFAM: response regulator receiver: (3e-37) transcriptional regulatory protein-like: (4e-21); KEGG: sil:SPO1679 DNA-binding response regulator CtrA, ev=1e-120, 90% identity YP_613395.1 KEGG: sil:SPO1678 hypothetical protein, ev=6e-32, 70% identity YP_613396.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_613397.1 KEGG: sil:SPO1675 lipid-A-disaccharide synthase, ev=1e-157, 74% identity; TIGRFAM: lipid-A-disaccharide synthase: (1.6e-61); PFAM: glycosyl transferase, family 19: (2e-88) YP_613398.1 PFAM: protein of unknown function DUF1009: (1.9e-50); KEGG: sil:SPO1674 hypothetical protein, ev=3e-89, 61% identity YP_613399.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_613400.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_613401.1 PFAM: outer membrane chaperone Skp (OmpH): (4.6e-14); KEGG: sil:SPO1671 hypothetical protein, ev=3e-34, 46% identity YP_613402.1 PFAM: surface antigen (D15): (4.4e-40) surface antigen variable number: (2.1e-14); KEGG: sil:SPO1670 outer membrane protein, OMP85 family, ev=0.0, 63% identity YP_613403.1 KEGG: sil:SPO1669 hypothetical protein, ev=9e-07, 60% identity YP_613404.1 TIGRFAM: Peptidase M50, membrane-associated zinc metallopeptidase: (4.7e-61); PFAM: PDZ/DHR/GLGF: (0.014) peptidase M50: (1e-65); KEGG: sil:SPO1668 membrane-associated zinc metalloprotease, , ev=1e-156, 59% identity YP_613405.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_613406.1 PFAM: phosphatidate cytidylyltransferase: (2.5e-51); KEGG: sil:SPO1666 phosphatidate cytidylyltransferase, ev=2e-64, 50% identity YP_613407.1 KEGG: sil:SPO1665 UDP diphosphate synthase, ev=1e-115, 84% identity; TIGRFAM: UDP diphosphate synthase: (1.8e-103); PFAM: Di-trans-poly-cis-decaprenylcistransferase: (9.2e-107) YP_613408.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_613409.1 Catalyzes the phosphorylation of UMP to UDP YP_613410.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_613411.1 PFAM: helix-turn-helix, AraC type: (5.4e-08); KEGG: sil:SPO1660 transcriptional regulator, AraC family, ev=1e-50, 44% identity YP_613412.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.0056); PFAM: extracellular solute-binding protein, family 5: (1.4e-47); KEGG: sil:SPO1659 oligopeptide/dipeptide ABC transporter, periplasmic substrate-binding protein, ev=0.0, 77% identity YP_613413.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.1e-26); KEGG: sil:SPO1658 oligopeptide/dipeptide ABC transporter, permease protein, ev=1e-161, 81% identity YP_613414.1 PFAM: binding-protein-dependent transport systems inner membrane component: (2.3e-32); KEGG: sil:SPO1657 oligopeptide/dipeptide ABC transporter, permease protein, ev=1e-176, 79% identity YP_613415.1 KEGG: sil:SPO1656 oligopeptide/dipeptide ABC transporter, ATP-binding protein, ev=0.0, 89% identity; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein-like: (3.3e-26); PFAM: ABC transporter related: (2.8e-59) Oligopeptide/dipeptide ABC transporter-like: (3.5e-26); SMART: ATPase: (5.7e-18) YP_613416.1 PFAM: Tetratricopeptide TPR_2: (0.00025); KEGG: ccr:CC3128 TPR domain protein, ev=1e-19, 23% identity YP_613417.1 PFAM: Di-haem cytochrome c peroxidase: (1e-49); KEGG: atc:AGR_C_5068 methylamine utilization protein MauG precursor, ev=1e-112, 57% identity YP_613419.1 PFAM: Lytic transglycosylase, catalytic: (1.7e-29); KEGG: sil:SPO1638 transglycosylase SLT domain protein, ev=1e-60, 60% identity YP_613420.1 TIGRFAM: single-strand binding protein: (4.6e-61); PFAM: single-strand binding protein/Primosomal replication protein n: (8e-33); KEGG: sil:SPO1637 single-strand binding protein, ev=1e-79, 82% identity YP_613421.1 PFAM: FAD dependent oxidoreductase: (9.9e-90) glycine cleavage T protein (aminomethyl transferase): (2.9e-46); KEGG: sil:SPO1628 aminomethyl transferase family protein, ev=0.0, 82% identity YP_613422.1 PFAM: CBS: (1.4e-28) protein of unknown function DUF21: (4e-56) transporter-associated region: (9.6e-28); KEGG: sil:SPO1631 CBS domain protein, ev=0.0, 79% identity YP_613423.1 PFAM: phage integrase: (5.1e-41) phage integrase-like SAM-like: (4.3e-13); KEGG: sil:SPO1632 tyrosine recombinase XerD, ev=1e-132, 75% identity YP_613424.1 KEGG: rsp:RSP_2816 hypothetical protein, ev=1e-111, 46% identity YP_613426.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_613427.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_613428.1 KEGG: rsp:RSP_2928 hypothetical protein, ev=1e-35, 47% identity YP_613429.1 KEGG: sil:SPO1626 type I secretion target repeat protein, ev=8e-80, 69% identity YP_613431.1 PFAM: Enoyl-CoA hydratase/isomerase: (7.7e-38); KEGG: sil:SPO1687 enoyl-CoA hydratase/isomerase family protein, ev=2e-83, 61% identity YP_613432.1 PFAM: inositol monophosphatase: (7.9e-31); KEGG: sme:SMc00535 hypothetical protein, ev=8e-54, 41% identity YP_613433.1 PFAM: MscS Mechanosensitive ion channel: (3.6e-74); KEGG: sil:SPO1922 mechanosensitive ion channel family protein, ev=0.0, 55% identity YP_613434.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_613435.1 KEGG: sil:SPO1919 tellurite resistance protein, ev=6e-44, 56% identity YP_613436.1 PFAM: DNA photolyase, FAD-binding: (6.9e-79) DNA photolyase-like: (2.1e-40); KEGG: sil:SPO1917 deoxyribodipyrimidine photolyase, ev=1e-167, 58% identity YP_613437.1 PFAM: aminotransferase, class V: (3.3e-28); KEGG: sil:SPO1916 aminotransferase, class V, ev=0.0, 77% identity YP_613438.1 PFAM: Alcohol dehydrogenase, zinc-binding: (2.3e-16) Alcohol dehydrogenase GroES-like: (4.1e-09); KEGG: sil:SPO1914 oxidoreductase, zinc-binding dehydrogenase family, ev=1e-157, 84% identity YP_613439.1 DmdA; DMSP demethylase; in Silicibacter knockout of this gene results in an inability to convert DMSP to methanethiol which is restored with a cloned copy of the gene YP_613440.1 PFAM: protein of unknown function DUF1326: (2.5e-77); KEGG: jan:Jann_2383 protein of unknown function DUF1326, ev=1e-103, 86% identity YP_613441.1 KEGG: jan:Jann_2384 hypothetical protein, ev=9e-89, 62% identity YP_613442.1 PFAM: regulatory protein GntR, HTH: (5.9e-17) GntR-like: (1.2e-14); KEGG: jan:Jann_2385 regulatory protein GntR, HTH, ev=3e-94, 75% identity YP_613443.1 PFAM: protein of unknown function DUF1486: (2.1e-05); KEGG: sil:SPO1909 hypothetical protein, ev=6e-22, 33% identity YP_613444.1 PFAM: Chromate transporter: (1.2e-38); KEGG: sil:SPO1908 chromate transporter, ev=1e-132, 60% identity YP_613445.1 PFAM: protein of unknown function DUF1321: (5.5e-58); KEGG: sil:SPO1907 hypothetical protein, ev=3e-61, 70% identity YP_613446.1 KEGG: sil:SPO1906 hypothetical protein, ev=1e-52, 59% identity YP_613447.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_613448.1 KEGG: sil:SPO1626 type I secretion target repeat protein, ev=5e-39, 41% identity YP_613449.1 KEGG: jan:Jann_2395 uncharacterized arylsulfate sulfotransferase-like protein, ev=4e-17, 61% identity YP_613450.1 PFAM: cytochrome P450: (2.8e-56); KEGG: sil:SPO1898 cytochrome P450 family protein, ev=0.0, 75% identity YP_613451.1 KEGG: sil:SPO1897 hypothetical protein, ev=1e-142, 63% identity YP_613452.1 PFAM: cytochrome c biogenesis protein, transmembrane region: (3e-59); KEGG: sil:SPO1896 cytochrome c-type biogenesis protein CcdA, ev=1e-118, 86% identity YP_613453.1 PFAM: SirA-like: (8.6e-22); KEGG: sil:SPO1895 SirA family protein, ev=2e-25, 70% identity YP_613454.1 TIGRFAM: ribonuclease, Rne/Rng family: (5.3e-203); KEGG: sil:SPO1893 ribonuclease, Rne/Rng family, ev=0.0, 69% identity YP_613455.1 TIGRFAM: HAD-superfamily hydrolase subfamily IA, variant 3: (7.8e-10); PFAM: Haloacid dehalogenase-like hydrolase: (2.5e-31); KEGG: bpm:BURPS1710b_1218 hydrolase, ev=1e-26, 35% identity YP_613456.1 PFAM: response regulator receiver: (5.5e-44) sigma-54 factor, interaction region: (1.6e-28) helix-turn-helix, Fis-type: (9.6e-07) ATPase associated with various cellular activities, AAA_5: (0.00016); SMART: ATPase: (9.8e-10); KEGG: sil:SPO1892 C4-dicarboxylate transport transcriptional regulatory protein DctD, ev=0.0, 92% identity YP_613457.1 PFAM: ATP-binding region, ATPase-like: (3.7e-29) histidine kinase A-like: (9.4e-10); KEGG: sil:SPO1891 C4-dicarboxylate transport sensor protein DctB, , ev=0.0, 80% identity YP_613458.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_613459.1 PFAM: phosphoribosylformylglycinamidine synthetase PurS: (5.4e-32); KEGG: sil:SPO1888 phosphoribosylformylglycinamidine synthase, PurS protein, ev=2e-31, 88% identity YP_613460.2 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_613461.1 PFAM: protein of unknown function DUF1476: (7.2e-47); KEGG: rsp:RSP_2125 hypothetical protein, ev=9e-26, 57% identity YP_613462.1 KEGG: sil:SPO1885 membrane protein, , ev=1e-131, 45% identity YP_613463.1 catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine YP_613464.1 PFAM: Radical SAM: (2.1e-23); SMART: Elongator protein 3/MiaB/NifB: (1.7e-12); KEGG: sil:SPO2159 radical SAM domain protein, ev=1e-153, 78% identity YP_613465.1 PFAM: Methionine synthase, B12-binding module, cap: (3.2e-14) cobalamin B12-binding: (3.7e-36); KEGG: sil:SPO2160 corrinoid methyltransferase protein, , ev=1e-118, 92% identity YP_613466.1 KEGG: sil:SPO2162 hypothetical protein, ev=3e-72, 63% identity YP_613467.1 PFAM: Fe-S metabolism associated SufE: (1.6e-41); KEGG: sil:SPO2165 Fe-S metabolism associated family protein, ev=3e-57, 80% identity YP_613468.1 KEGG: sil:SPO2166 lipoprotein, , ev=4e-36, 51% identity YP_613469.1 TIGRFAM: ribonuclease D: (2.6e-133); PFAM: 3'-5' exonuclease: (4.6e-48); KEGG: sil:SPO2167 ribonuclease D, ev=1e-178, 81% identity YP_613470.1 TIGRFAM: phosphoribosylglycinamide formyltransferase: (1.3e-58); PFAM: formyl transferase-like: (4.9e-47); KEGG: sil:SPO2168 phosphoribosylglycinamide formyltransferase, ev=5e-75, 78% identity YP_613471.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_613472.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.013); PFAM: beta-lactamase-like: (7.8e-21); KEGG: sil:SPO2170 metallo-beta-lactamase family protein, ev=1e-108, 62% identity YP_613473.1 PFAM: regulatory protein, LysR: (2.6e-16) LysR, substrate-binding: (4.7e-32); KEGG: sil:SPO2171 transcriptional regulator, LysR family, ev=1e-115, 67% identity YP_613474.1 PFAM: ATP-binding region, ATPase-like: (3.2e-23) histidine kinase, HAMP region: (7.9e-12) histidine kinase A-like: (7.7e-12); KEGG: sil:SPO2173 sensor histidine kinase, ev=1e-126, 56% identity YP_613475.1 PFAM: beta-lactamase-like: (3.6e-24); KEGG: sil:SPO2174 metallo-beta-lactamase family protein, ev=1e-104, 62% identity YP_613476.1 PFAM: NAD-dependent epimerase/dehydratase: (3.1e-87) dTDP-4-dehydrorhamnose reductase: (1e-05); KEGG: rru:Rru_A0254 NAD-dependent epimerase/dehydratase, ev=1e-115, 65% identity YP_613477.1 TIGRFAM: GDP-mannose 4,6-dehydratase: (4.2e-257); PFAM: NAD-dependent epimerase/dehydratase: (1.7e-107); KEGG: vvy:VV0349 GDP-mannose-4,6-dehydratase, ev=0.0, 82% identity YP_613478.1 PFAM: DegT/DnrJ/EryC1/StrS aminotransferase: (1.3e-76) aromatic amino acid beta-eliminating lyase/threonine aldolase: (0.0031); KEGG: cac:CAC2178 predicted CDP-4-keto-6-deoxy-D-glucose-3-dehydrase, ev=1e-61, 32% identity YP_613479.1 PFAM: glycosyl transferase, family 2: (4.4e-26); KEGG: bfs:BF2599 LPS biosynthesis related glycosyltransferase, ev=7e-23, 32% identity YP_613480.1 PFAM: NAD-dependent epimerase/dehydratase: (3e-28) 3-beta hydroxysteroid dehydrogenase/isomerase: (0.0046) dTDP-4-dehydrorhamnose reductase: (2.1e-10) Male sterility-like: (0.00022); KEGG: rru:Rru_A1486 UDP-glucose 4-epimerase, ev=3e-16, 29% identity YP_613482.1 KEGG: jan:Jann_1379 methyl-accepting chemotaxis sensory transducer with PAS/Pac sensor, ev=1e-117, 52% identity; TIGRFAM: PAS: (6.3e-18); PFAM: chemotaxis sensory transducer: (3.8e-78) PAS fold-3: (5.1e-19) PAS fold-4: (4e-08) PAS fold: (0.00084); SMART: PAC motif: (6.7e-09) YP_613483.1 PFAM: Hemolysin-type calcium-binding region: (0.08); KEGG: jan:Jann_1066 hemolysin-type calcium-binding protein, ev=2e-80, 38% identity YP_613484.1 TIGRFAM: Acetate--CoA ligase: (0); PFAM: AMP-dependent synthetase and ligase: (1.2e-135); KEGG: sil:SPO1813 acetyl-coenzyme A synthetase, ev=0.0, 89% identity YP_613485.1 TIGRFAM: adenylate kinases: (9.7e-102); PFAM: adenylate kinase: (3.6e-86) adenylate kinase, lid region: (1.1e-09); KEGG: sil:SPO1812 adenylate kinase, ev=5e-88, 75% identity YP_613486.1 PFAM: flavin reductase-like, FMN-binding: (3.4e-36); KEGG: sil:SPO1806 flavin reductase domain protein, ev=2e-37, 48% identity YP_613487.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding: (6.7e-06); KEGG: vvy:VV1703 ferredoxin, ev=2e-10, 41% identity YP_613488.1 KEGG: sil:SPO1788 ABC transporter, periplasmic substrate-binding protein, ev=1e-150, 80% identity YP_613489.1 PFAM: binding-protein-dependent transport systems inner membrane component: (4e-31); KEGG: sil:SPO1787 ABC transporter, permease protein, ev=1e-132, 83% identity YP_613490.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.1e-33); KEGG: sil:SPO1786 ABC transporter, permease protein, ev=1e-136, 81% identity YP_613491.1 PFAM: ABC transporter related: (4.7e-47); SMART: ATPase: (1.6e-15); KEGG: sil:SPO1785 ABC transporter, ATP-binding protein, ev=1e-125, 85% identity YP_613492.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position YP_613493.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_613494.1 PFAM: regulatory protein, TetR: (1.6e-17) Tetracycline transcriptional regulator YcdC-like-like: (9.4e-60); KEGG: sil:SPO1780 transcriptional regulator, TetR family, ev=2e-74, 67% identity YP_613495.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines YP_613496.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_613497.1 KEGG: jan:Jann_2635 hypothetical protein, ev=2e-29, 79% identity YP_613498.1 KEGG: sil:SPO1032 hypothetical protein, ev=3e-18, 60% identity YP_613499.1 KEGG: sil:SPO1031 hypothetical protein, ev=4e-08, 40% identity YP_613500.1 PFAM: protein of unknown function DUF442: (3.1e-44); KEGG: sil:SPO1027 conserved hypothetical protein TIGR01244, ev=6e-48, 67% identity YP_613501.1 PFAM: surface presentation of antigens (SPOA) protein: (0.0028); KEGG: sil:SPO1026 hypothetical protein, ev=2e-49, 33% identity YP_613502.1 PFAM: ATP-binding region, ATPase-like: (6.9e-31) histidine kinase A-like: (9.4e-22); KEGG: sil:SPO1025 sensor histidine kinase, ev=0.0, 74% identity YP_613503.1 KEGG: sil:SPO1024 hypothetical protein, ev=8e-13, 52% identity YP_613504.1 PFAM: response regulator receiver: (5.6e-31); KEGG: sil:SPO1023 response regulator, ev=2e-47, 77% identity YP_613505.1 PFAM: helix-turn-helix motif: (5e-13); KEGG: sil:SPO1022 transcriptional regulator, , ev=1e-145, 62% identity YP_613506.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.015); KEGG: sil:SPO1021 branched-chain amino acid ABC transporter, periplasmic substrate-binding protein, ev=0.0, 77% identity YP_613507.1 PFAM: inner-membrane translocator: (8.4e-24); KEGG: sil:SPO1020 branched-chain amino acid ABC transporter, permease protein, ev=1e-163, 84% identity YP_613508.1 PFAM: inner-membrane translocator: (3.8e-17); KEGG: sil:SPO1019 branched-chain amino acid ABC transporter, permease protein, ev=1e-179, 77% identity YP_613509.1 PFAM: ABC transporter related: (3.8e-45); SMART: ATPase: (8.6e-09); KEGG: sil:SPO1018 branched-chain amino acid ABC transporter, ATP-binding protein, ev=1e-123, 88% identity YP_613510.1 PFAM: ABC transporter related: (5.4e-43); SMART: ATPase: (1.4e-10); KEGG: sil:SPO1017 branched-chain amino acid ABC transporter, ATP-binding protein, ev=1e-126, 90% identity YP_613511.1 PFAM: regulatory protein, LuxR: (1.7e-17); KEGG: sil:SPO1012 transcriptional regulator, LuxR family, ev=2e-59, 63% identity YP_613512.1 TIGRFAM: acetyl-CoA carboxylase, biotin carboxyl carrier protein: (6.2e-38); PFAM: biotin/lipoyl attachment: (6e-29); KEGG: sil:SPO1011 acetyl-CoA carboxylase, biotin carboxyl carrier protein, ev=3e-60, 74% identity YP_613513.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_613514.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_613515.1 KEGG: sil:SPO1008 hypothetical protein, ev=3e-32, 69% identity YP_613516.1 PFAM: Mammalian cell entry related: (8.4e-22); KEGG: sil:SPO1007 ABC transport system substrate-binding protein, ev=4e-51, 71% identity YP_613517.1 Provides the input to the respiratory chain from the NAD-linked dehydrogenases of the citric acid cycle. The complex couples the oxidation of NADH and the reduction of ubiquinone, to the generation of a proton gradient which is then used for ATP synthesis YP_613518.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (2e-08); KEGG: ppu:PP3509 glyoxalase family protein, ev=5e-37, 59% identity YP_613519.1 PFAM: Endoribonuclease L-PSP: (2.8e-20); KEGG: sil:SPO1005 endoribonuclease L-PSP family protein, ev=7e-52, 84% identity YP_613520.1 PFAM: dienelactone hydrolase: (3.5e-35); KEGG: mca:MCA1803 dienelactone hydrolase family protein, ev=2e-55, 48% identity YP_613521.1 binds and unfolds substrates as part of the ClpXP protease YP_613522.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_613523.1 PFAM: helix-turn-helix, AraC type: (1.9e-09) ThiJ/PfpI: (0.0001); KEGG: sil:SPO1002 transcriptional regulator, AraC family, ev=1e-118, 60% identity YP_613524.1 KEGG: sil:SPO2884 hypothetical protein, ev=1e-45, 63% identity YP_613525.1 PFAM: thiamine pyrophosphate enzyme-like TPP-binding: (8.2e-35) thiamine pyrophosphate enzyme, central region: (2.8e-11) thiamine pyrophosphate enzyme-like TPP binding region: (4e-34); KEGG: sil:SPO2885 acetolactate synthase, catabolic, , ev=0.0, 70% identity YP_613526.1 PFAM: L-carnitine dehydratase/bile acid-inducible protein F: (2.5e-66); KEGG: sil:SPO2886 CAIB/BAIF family protein, ev=1e-155, 69% identity YP_613527.1 KEGG: sil:SPO2887 hypothetical protein, ev=1e-167, 63% identity YP_613528.1 KEGG: sil:SPO2888 membrane protein, , ev=1e-151, 61% identity YP_613529.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_613530.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_613531.1 KEGG: sil:SPO2891 polyhydroxybutyrate depolymerase, ev=2e-74, 51% identity YP_613532.1 SMART: Rhodanese-like: (6.8e-12); KEGG: sil:SPO2892 hypothetical protein, ev=4e-32, 54% identity YP_613533.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved with K+ YP_613534.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_613535.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_613536.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_613537.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_613538.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_613539.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (0.00032) AIR synthase related protein-like: (1.6e-16); KEGG: sil:SPO2899 selenide,water dikinase, , ev=0.0, 63% identity YP_613540.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_613541.1 PFAM: regulatory protein, MarR: (1.6e-14); KEGG: bja:bll4221 transcriptional regulatory protein, ev=5e-27, 48% identity YP_613542.1 KEGG: bte:BTH_I2061 hypothetical protein, ev=8e-11, 45% identity YP_613543.1 PFAM: metallophosphoesterase: (3.6e-21) 5'-Nucleotidase-like: (3e-67); KEGG: sil:SPO2904 Ser/Thr protein phosphatase/nucleotidase, , ev=0.0, 62% identity YP_613544.1 PFAM: protein of unknown function DUF952: (7.4e-46); KEGG: sil:SPO2905 hypothetical protein, ev=9e-45, 77% identity YP_613545.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_613546.1 TIGRFAM: MATE efflux family protein: (4e-69); PFAM: multi antimicrobial extrusion protein MatE: (3.6e-17); KEGG: rsp:RSP_2204 multidrug efflux pump, MATE family, ev=1e-154, 63% identity YP_613547.1 KEGG: rsp:RSP_2203 hypothetical protein, ev=1e-63, 72% identity YP_613548.1 TIGRFAM: Phenylacetic acid degradation-related protein: (4.8e-17); PFAM: thioesterase superfamily: (2.1e-16); KEGG: sil:SPO2911 thioesterase family protein, ev=1e-58, 78% identity YP_613549.1 PFAM: regulatory protein, MerR: (3e-05); KEGG: sil:SPO2912 transcriptional regulator, MerR family, ev=3e-46, 75% identity YP_613551.1 PFAM: regulatory protein, MerR: (2.3e-10); KEGG: sil:SPO2914 transcriptional regulator, MerR family, ev=1e-57, 81% identity YP_613552.1 PFAM: acyl-CoA dehydrogenase-like: (3.9e-22); KEGG: sil:SPO2915 acyl-CoA dehydrogenase family protein, ev=0.0, 87% identity YP_613553.1 KEGG: sil:SPO2916 hypothetical protein, ev=8e-29, 87% identity YP_613554.1 PFAM: acyl-CoA dehydrogenase-like: (3.6e-53) Acyl-CoA dehydrogenase, type 2-like: (1.5e-06); KEGG: bur:Bcep18194_C7184 acyl-CoA dehydrogenase, ev=1e-133, 58% identity YP_613555.1 PFAM: glutathione S-transferase-like: (1.3e-10); KEGG: sil:SPO2917 glutathione S-transferase family protein, ev=1e-94, 76% identity YP_613556.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_613557.1 PFAM: Enoyl-CoA hydratase/isomerase: (3.8e-25) 3-hydroxyacyl-CoA dehydrogenase-like: (6.6e-24) 3-hydroxyacyl-CoA dehydrogenase, NAD-binding: (9.5e-85) NAD-dependent glycerol-3-phosphate dehydrogenase-like: (0.00045); KEGG: sil:SPO2920 fatty oxidation complex, alpha subunit, ev=0.0, 86% identity YP_613558.1 KEGG: sil:SPO2921 hypothetical protein, ev=2e-35, 41% identity YP_613559.1 KEGG: sil:SPO2922 hypothetical protein, ev=1e-70, 59% identity YP_613560.1 PFAM: AMP-dependent synthetase and ligase: (5.5e-105); KEGG: jan:Jann_2979 AMP-dependent synthetase and ligase, ev=0.0, 72% identity YP_613561.1 KEGG: vvy:VV1861 hypothetical protein, ev=5e-27, 41% identity YP_613562.1 KEGG: sil:SPO2924 hypothetical protein, ev=1e-107, 56% identity YP_613563.1 PFAM: Sporulation related: (3e-05); KEGG: jan:Jann_2982 hypothetical protein, ev=3e-32, 30% identity YP_613564.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_613565.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_613566.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_613567.1 TIGRFAM: Cytidine deaminase, homotetrameric: (9.3e-42); PFAM: CMP/dCMP deaminase, zinc-binding: (3.8e-13); KEGG: sil:SPO2930 cytidine deaminase, ev=3e-50, 74% identity YP_613568.1 NAD-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; does not decarboxylate oxaloacetate YP_613569.1 PFAM: AMP-dependent synthetase and ligase: (2.7e-112); KEGG: sil:SPO2934 propionate--CoA ligase, ev=0.0, 85% identity YP_613570.1 PFAM: CsbD-like: (3.4e-09); KEGG: noc:Noc_0274 CsbD-like protein, ev=6e-19, 60% identity YP_613572.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_613573.1 catalyzes the phosphorylation of NAD to NADP YP_613574.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_613575.1 PFAM: protein of unknown function DUF159: (2e-25); KEGG: rsp:RSP_2605 hypothetical protein, ev=4e-30, 35% identity YP_613576.1 KEGG: jan:Jann_2992 hypothetical protein, ev=6e-30, 69% identity YP_613577.1 KEGG: jan:Jann_2993 phage shock protein A, PspA, ev=3e-54, 53% identity YP_613578.1 PFAM: regulatory protein, TetR: (0.0022); KEGG: jan:Jann_2994 transcriptional regulator, TetR family, ev=4e-54, 55% identity YP_613579.1 PFAM: protein of unknown function DUF817: (1.2e-94); KEGG: sil:SPO2941 membrane protein, , ev=1e-115, 78% identity YP_613580.1 KEGG: sil:SPO2942 hypothetical protein, ev=1e-12, 34% identity YP_613581.1 PFAM: alpha/beta hydrolase fold: (7.3e-21) PGAP1-like: (6.8e-05); KEGG: sil:SPO2943 hydrolase, alpha/beta fold family, ev=1e-104, 74% identity YP_613582.1 TIGRFAM: DNA adenine methylase: (2.5e-13); PFAM: D12 class N6 adenine-specific DNA methyltransferase: (8.1e-18); KEGG: vpa:VP2742 DNA adenine methylase, ev=3e-20, 30% identity YP_613583.1 TIGRFAM: Outer membrane autotransporter barrel: (4.1e-09); PFAM: Hyalin: (0.00045) Autotransporter beta-domain: (1.1e-08); KEGG: hch:HCH_03195 RTX toxins and related Ca2+-binding protein, ev=3e-47, 26% identity YP_613584.1 TIGRFAM: TRAP dicarboxylate transporter- DctM subunit: (3.7e-110); PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (4.1e-105); KEGG: jan:Jann_1450 TRAP dicarboxylate transporter-DctM subunit, ev=1e-180, 74% identity YP_613585.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component: (2.5e-07); KEGG: jan:Jann_1449 tripartite ATP-independent periplasmic transporter, DctQ component, ev=6e-57, 63% identity YP_613586.1 PFAM: TRAP dicarboxylate transporter- DctP subunit: (8.8e-43); KEGG: sil:SPO1773 TRAP dicarboxylate transporter, DctP subunit, , ev=1e-124, 70% identity YP_613587.1 catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde in the final enzymatic step of quinolinate biosynthesis YP_613588.1 PFAM: protein of unknown function DUF6, transmembrane: (0.00071); KEGG: eba:p2A115 hypothetical protein, potential permease subunit, ev=8e-21, 27% identity YP_613589.1 PFAM: dihydrodipicolinate synthetase: (1e-11); KEGG: sil:SPO2882 dihydrodipicolinate synthase family protein, ev=1e-132, 72% identity YP_613590.1 catalyzes the formation of L-aspartate to iminoaspartate in NAD(+) biosynthesis YP_613591.1 PFAM: regulatory protein, LysR: (5.4e-21) LysR, substrate-binding: (1.4e-36); KEGG: sil:SPO2879 transcriptional regulator, LysR family, ev=5e-97, 60% identity YP_613592.1 PFAM: aldehyde dehydrogenase: (7.2e-185); KEGG: atc:AGR_L_2660 aldehyde dehydrogenase, ev=1e-135, 49% identity YP_613593.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.068); PFAM: major facilitator superfamily MFS_1: (3.1e-26); KEGG: sil:SPO2225 membrane protein, , ev=1e-110, 49% identity YP_613594.1 PFAM: Hemolysin-type calcium-binding region: (0.00015); KEGG: rpb:RPB_0803 5'-nucleotidase, ev=4e-36, 40% identity YP_613599.1 PFAM: protein of unknown function DUF847: (8.8e-67); KEGG: bmb:BruAb1_0990 secretion activator protein, hypothetical, ev=2e-43, 39% identity YP_613604.1 KEGG: nar:Saro_2740 PE-PGRS family protein, ev=2e-34, 37% identity YP_613605.1 KEGG: rsp:RSP_1635 hypothetical protein, ev=2e-27, 27% identity YP_613606.1 KEGG: rsp:RSP_3791 hypothetical protein, ev=2e-86, 23% identity YP_613608.1 KEGG: rsp:RSP_3788 hypothetical protein, ev=2e-29, 46% identity YP_613609.1 KEGG: nar:Saro_0657 hypothetical protein, ev=2e-32, 50% identity YP_613611.1 KEGG: rsp:RSP_6012 hypothetical protein, ev=1e-08, 36% identity YP_613612.1 KEGG: rsp:RSP_1640 hypothetical protein, ev=5e-14, 35% identity YP_613614.1 TIGRFAM: Phage conserved hypothetical protein, phiE125 gp8: (7.5e-10); KEGG: nar:Saro_0652 phage conserved hypothetical protein, phiE125 gp8, ev=3e-15, 35% identity YP_613617.1 KEGG: ppu:PP3877 hypothetical protein, ev=3e-77, 41% identity YP_613618.1 PFAM: peptidase S49: (1.8e-23); KEGG: nmu:Nmul_A0057 peptidase S49, ev=1e-42, 41% identity YP_613619.1 TIGRFAM: Phage portal protein, HK97: (7.5e-44); PFAM: phage portal protein: (6.5e-40); KEGG: det:DET1087 portal protein, HK97 family, , ev=1e-51, 33% identity YP_613620.1 PFAM: phage Terminase: (6.4e-10); KEGG: rsp:RSP_2070 phage-related terminase, ev=1e-156, 52% identity YP_613624.1 KEGG: pca:Pcar_1822 conserved hypothetical protein, ev=2e-23, 25% identity YP_613627.1 KEGG: rsp:RSP_0134 hypothetical protein, ev=6e-11, 47% identity YP_613628.1 KEGG: mag:amb1747 hypothetical protein, ev=1e-12, 31% identity YP_613631.1 SMART: Helix-turn-helix type 3: (1.5e-09) YP_613637.1 KEGG: rsp:RSP_3609 ParB-like nuclease, ev=1e-100, 38% identity YP_613639.1 KEGG: nwi:Nwi_1140 phage integrase, ev=1e-24, 29% identity YP_613640.1 PFAM: Resolvase-like: (8.9e-52); KEGG: ece:Z0318 DNA invertase from prophage CP-933H, ev=1e-33, 49% identity YP_613645.1 PFAM: protein of unknown function DUF847: (8.8e-67); KEGG: bmb:BruAb1_0990 secretion activator protein, hypothetical, ev=1e-43, 39% identity YP_613650.1 KEGG: pub:SAR11_0932 hypothetical protein, ev=2e-20, 32% identity YP_613651.1 KEGG: nar:Saro_0661 hypothetical protein, ev=7e-28, 26% identity YP_613652.1 KEGG: rsp:RSP_3791 hypothetical protein, ev=5e-91, 24% identity YP_613656.1 KEGG: rsp:RSP_3788 hypothetical protein, ev=2e-29, 46% identity YP_613657.1 KEGG: nar:Saro_0657 hypothetical protein, ev=2e-32, 50% identity YP_613659.1 KEGG: rsp:RSP_6012 hypothetical protein, ev=3e-07, 35% identity YP_613660.1 KEGG: rsp:RSP_1640 hypothetical protein, ev=2e-14, 35% identity YP_613661.1 TIGRFAM: conserved hypothetical protein: (0.13) YP_613662.1 TIGRFAM: Phage conserved hypothetical protein, phiE125 gp8: (3.6e-09); KEGG: nar:Saro_0652 phage conserved hypothetical protein, phiE125 gp8, ev=3e-12, 30% identity YP_613663.1 KEGG: nar:Saro_0649 phage major capsid protein, HK97, ev=1e-103, 52% identity YP_613664.1 PFAM: peptidase U35, phage prohead HK97: (2.4e-50); KEGG: hch:HCH_04554 phage prohead protease, HK97 family, ev=9e-29, 46% identity YP_613665.1 TIGRFAM: Phage portal protein, HK97: (1.7e-95); PFAM: phage portal protein: (3.6e-100); KEGG: nar:Saro_0647 phage portal protein, HK97, ev=1e-102, 52% identity YP_613666.1 PFAM: phage Terminase: (9.1e-37); KEGG: sgl:SG0724 phage terminase large subunit, ev=1e-100, 37% identity YP_613671.1 TIGRFAM: single-strand binding protein: (7.4e-57); PFAM: single-strand binding protein/Primosomal replication protein n: (4e-32); KEGG: sil:SPO1637 single-strand binding protein, ev=5e-63, 68% identity YP_613673.1 PFAM: endodeoxyribonuclease RusA: (0.0097) YP_613674.1 PFAM: MT-A70: (1.7e-36); KEGG: ana:all7280 adenine-specific DNA methyltransferase, ev=1e-25, 35% identity YP_613677.1 KEGG: rsp:RSP_3771 hypothetical protein, ev=4e-17, 47% identity YP_613678.1 KEGG: noc:Noc_2744 hypothetical protein, ev=2e-08, 38% identity YP_613679.1 PFAM: protein of unknown function UPF0150: (1.1e-18); KEGG: noc:Noc_2743 hypothetical protein, ev=4e-18, 58% identity YP_613682.1 KEGG: sgl:SG1827 hypothetical protein, ev=4e-58, 41% identity YP_613683.1 KEGG: lpf:lpl1360 hypothetical protein, ev=1e-10, 30% identity YP_613685.1 SMART: HNH nuclease: (2.4e-06); KEGG: mlo:mll7975 hypothetical protein, ev=1e-10, 40% identity YP_613686.1 PFAM: C-5 cytosine-specific DNA methylase: (4e-07); KEGG: yps:YPTB1799 modification methylase, ev=1e-106, 37% identity YP_613687.1 PFAM: phage integrase: (0.0014); KEGG: mag:amb2709 integrase, ev=4e-15, 25% identity YP_613688.1 PFAM: TPR repeat: (0.078) Tetratricopeptide TPR_2: (2.3e-06); SMART: Tetratricopeptide region: (0.059); KEGG: sil:SPO3008 TPR domain protein, ev=8e-62, 63% identity YP_613689.1 PFAM: regulatory proteins, AsnC/Lrp: (1.2e-20); KEGG: sil:SPO3009 proline dehydrogenase transcriptional activator, ev=2e-56, 67% identity YP_613690.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain YP_613691.1 PFAM: Rhomboid-like protein: (1.1e-40); KEGG: sil:SPO3011 rhomboid family protein, ev=6e-91, 65% identity YP_613692.1 PFAM: glutathione-dependent formaldehyde-activating, GFA: (2.5e-19); KEGG: rsp:RSP_2168 hypothetical protein, ev=4e-39, 61% identity YP_613693.1 PFAM: inositol monophosphatase: (6.5e-71); KEGG: sil:SPO3012 inositol-1-monophosphatase, , ev=1e-130, 86% identity YP_613694.1 PFAM: regulatory protein, LysR: (1.1e-18) LysR, substrate-binding: (5.8e-36); KEGG: sil:SPO3015 transcriptional regulator MetR, ev=1e-143, 84% identity YP_613695.1 KEGG: sil:SPO3016 5,10-methylenetetrahydrofolate reductase, ev=1e-129, 78% identity; TIGRFAM: 5,10-methylenetetrahydrofolate reductase: (3.8e-128); PFAM: methylenetetrahydrofolate reductase: (9e-90) YP_613696.1 TIGRFAM: Phenylacetic acid degradation-related protein: (2.1e-16); PFAM: thioesterase superfamily: (1.1e-13); KEGG: sil:SPO3017 thioesterase family protein, ev=9e-57, 64% identity YP_613697.1 KEGG: eca:ECA3200 hypothetical protein, ev=7e-59, 39% identity YP_613698.1 PFAM: GCN5-related N-acetyltransferase: (8.5e-15); KEGG: jan:Jann_3325 GCN5-related N-acetyltransferase, ev=3e-47, 52% identity YP_613699.1 KEGG: sil:SPO3018 hypothetical protein, ev=1e-137, 68% identity YP_613700.1 PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead: (4.1e-25) aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding: (1.8e-119); KEGG: sil:SPO3019 xanthine dehydrogenase family protein, large subunit, ev=0.0, 71% identity YP_613701.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_613702.1 PFAM: protein of unknown function DUF1330: (7.9e-40); KEGG: rpa:RPA0338 hypothetical protein, ev=2e-24, 55% identity YP_613703.1 KEGG: sil:SPO1310 hypothetical protein, ev=6e-57, 77% identity YP_613704.1 PFAM: protein of unknown function DUF1332: (3.5e-18); KEGG: sil:SPO1309 hypothetical protein, ev=2e-44, 66% identity YP_613705.1 KEGG: sil:SPO1308 hypothetical protein, ev=2e-72, 54% identity YP_613706.1 PFAM: ABC transporter related: (7.4e-62); SMART: ATPase: (3.5e-15); KEGG: sil:SPO1307 His/Glu/Gln/Arg/opine family ABC transporter, ATP-binding protein, ev=1e-115, 77% identity YP_613707.1 PFAM: extracellular solute-binding protein, family 3: (7e-59); KEGG: sil:SPO1306 His/Glu/Gln/Arg/opine family ABC transporter, periplasmic His/Glu/Gln/Arg/opine family-binding protein, ev=4e-90, 70% identity YP_613708.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.2e-11); KEGG: sil:SPO1305 ABC transporter, permease protein, HisMQ family, ev=1e-128, 72% identity YP_613709.1 TIGRFAM: Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine: (4.2e-08); PFAM: binding-protein-dependent transport systems inner membrane component: (1.7e-16); KEGG: sil:SPO1304 His/Glu/Gln/Arg/opine family ABC transporter, permease protein, ev=1e-120, 75% identity YP_613710.1 TIGRFAM: Poly(R)-hydroxyalkanoic acid synthase, class I: (5.1e-292); PFAM: Poly-beta-hydroxybutyrate polymerase-like: (2.4e-108); KEGG: sil:SPO1292 poly(3-hydroxyalkanoate) polymerase, ev=0.0, 69% identity YP_613711.1 TIGRFAM: polyhydroxyalkanoate depolymerase, intracellular: (1.5e-245); PFAM: PHB de-polymerase-like: (7.5e-129); KEGG: sil:SPO1291 polyhydroxyalkanoate depolymerase, intracellular, ev=0.0, 81% identity YP_613712.1 KEGG: sil:SPO1290 hypothetical protein, ev=1e-52, 50% identity YP_613713.1 KEGG: sil:SPO1289 hydrolase, alpha/beta fold family, ev=3e-44, 44% identity YP_613714.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (3.8e-17); KEGG: sil:SPO1287 glyoxalase family protein, ev=7e-52, 66% identity YP_613715.1 KEGG: sil:SPO1285 hypothetical protein, ev=3e-98, 72% identity YP_613716.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_613717.1 KEGG: sil:SPO1281 hypothetical protein, ev=6e-41, 82% identity YP_613718.1 PFAM: protein of unknown function DUF692: (4.8e-111); KEGG: sil:SPO1280 hypothetical protein, ev=1e-131, 81% identity YP_613719.1 KEGG: sil:SPO1279 hypothetical protein, ev=2e-88, 66% identity YP_613720.1 PFAM: DoxX: (0.00021); KEGG: sil:SPO1278 hypothetical protein, ev=1e-81, 81% identity YP_613721.1 PFAM: arsenate reductase and related: (6.6e-12); KEGG: sil:SPO1276 ArsC family protein, ev=2e-31, 62% identity YP_613722.1 PFAM: Cold-shock protein, DNA-binding: (2.4e-28); SMART: Cold shock protein: (1.4e-22); KEGG: sil:SPO1275 cold shock family protein, ev=9e-29, 83% identity YP_613723.1 PFAM: dihydrofolate reductase region: (5.1e-44); KEGG: rsp:RSP_0389 dihydrofolate reductase, ev=3e-49, 59% identity YP_613724.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_613725.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (1.3e-20); KEGG: jan:Jann_1089 glyoxalase/bleomycin resistance protein/dioxygenase, ev=2e-64, 78% identity YP_613726.1 PFAM: regulatory protein, MarR: (1.1e-09); KEGG: jan:Jann_2651 transcriptional regulator, MarR family, ev=6e-70, 76% identity YP_613727.1 PFAM: protein of unknown function DUF339: (5.5e-20); KEGG: sil:SPO1266 TPR repeat family protein, ev=9e-26, 65% identity YP_613728.1 PFAM: helix-turn-helix motif: (1.7e-13); KEGG: sil:SPO1265 DNA-binding protein, , ev=2e-39, 64% identity YP_613729.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_613730.1 KEGG: jan:Jann_2660 hypothetical protein, ev=6e-49, 69% identity YP_613731.1 TIGRFAM: MATE efflux family protein: (4.8e-85); PFAM: multi antimicrobial extrusion protein MatE: (7.5e-40); KEGG: sil:SPO1260 MATE efflux family protein, ev=1e-163, 64% identity YP_613732.1 PFAM: high-affinity nickel-transporter: (9.5e-22); KEGG: jan:Jann_1929 high-affinity nickel-transporter, ev=8e-75, 46% identity YP_613733.1 KEGG: jan:Jann_1928 hypothetical protein, ev=6e-37, 42% identity YP_613734.1 TIGRFAM: Alkylhydroperoxidase AhpD core: (1e-06) Uncharacterised peroxidase-related: (1.2e-20); PFAM: Carboxymuconolactone decarboxylase: (0.0035); KEGG: sil:SPO1255 alkylhydroperoxidase AhpD family core domain protein, ev=5e-87, 75% identity YP_613735.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_613736.1 PFAM: cytochrome c, class I: (0.0041); KEGG: sil:SPOA0361 cytochrome c family protein, ev=2e-35, 60% identity YP_613737.1 PFAM: copper resistance D: (8.5e-07); KEGG: pha:PSHAb0008 copper export protein, ev=1e-22, 29% identity YP_613738.1 PFAM: copper resistance protein CopC: (5e-14); KEGG: bur:Bcep18194_A5818 copper resistance protein CopC, ev=2e-09, 27% identity YP_613739.1 PFAM: cytochrome c, class I: (0.0091); KEGG: sil:SPOA0359 cytochrome c family protein, ev=2e-28, 51% identity YP_613741.1 KEGG: ddi:DDB0168118 hypothetical protein, ev=5e-09, 30% identity YP_613742.1 PFAM: EAL: (2.8e-43); KEGG: ccr:CC3148 hypothetical protein, ev=2e-75, 56% identity YP_613743.1 PFAM: regulatory protein, LysR: (1.3e-20) LysR, substrate-binding: (1.5e-35); KEGG: sil:SPO3490 transcriptional regulator, LysR family, ev=1e-103, 63% identity YP_613744.1 PFAM: Methyltransferase type 11: (5.4e-22) Methyltransferase type 12: (4.2e-25); KEGG: sil:SPO3491 methyltransferase, UbiE/COQ5 family, ev=2e-44, 48% identity YP_613745.1 PFAM: ThiJ/PfpI: (1.5e-21); KEGG: sme:SMb20212 hypothetical protein, ev=3e-57, 52% identity YP_613746.1 PFAM: regulatory protein, LysR: (1.4e-21) LysR, substrate-binding: (1.3e-14); KEGG: bur:Bcep18194_B2495 transcriptional regulator, LysR family, ev=9e-39, 34% identity YP_613747.1 PFAM: Cold-shock protein, DNA-binding: (2.7e-29); SMART: Cold shock protein: (5.7e-25); KEGG: sil:SPO3625 cold shock protein CspA, ev=2e-24, 75% identity YP_613749.1 KEGG: rsp:RSP_3622 hypothetical protein, ev=6e-14, 45% identity YP_613750.1 PFAM: regulatory proteins, AsnC/Lrp: (1.5e-21); KEGG: sil:SPO2631 transcriptional regulator, AsnC family, ev=9e-71, 88% identity YP_613751.1 TIGRFAM: uroporphyrin-III C-methyltransferase: (1.4e-87); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase: (2e-56); KEGG: sil:SPO2632 uroporphyrin-III C-methyltransferase, ev=8e-92, 70% identity YP_613752.1 KEGG: sil:SPO2633 hypothetical protein, ev=2e-37, 78% identity YP_613753.1 PFAM: nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like: (1e-11) nitrite and sulphite reductase 4Fe-4S region: (3.1e-05); KEGG: sil:SPO2634 sulfite reductase, , ev=0.0, 78% identity YP_613754.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_613755.1 KEGG: sil:SPO2636 hypothetical protein, ev=2e-44, 67% identity YP_613756.1 PFAM: Oxidoreductase FAD-binding region: (0.00066); KEGG: jan:Jann_1770 ferredoxin--NADP(+) reductase, ev=1e-143, 85% identity YP_613757.1 KEGG: jan:Jann_1769 mucin-associated surface protein, ev=6e-27, 37% identity YP_613758.1 TIGRFAM: translation initiation factor IF-3: (1.6e-46); PFAM: initiation factor 3: (3.1e-54); KEGG: sil:SPO2638 translation initiation factor IF-3, ev=3e-70, 93% identity YP_613759.1 PFAM: molybdopterin dehydrogenase, FAD-binding: (1e-60); KEGG: sil:SPO1520 carbon monoxide dehydrogenase, medium subunit, , ev=1e-107, 76% identity YP_613760.1 PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead: (1.6e-34) aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding: (2.1e-157); KEGG: sil:SPO1519 carbon monoxide dehydrogenase, large subunit, ev=0.0, 88% identity YP_613761.1 PFAM: ferredoxin: (1.7e-05) [2Fe-2S]-binding: (9.8e-46); KEGG: jan:Jann_1763 (2Fe-2S)-binding, ev=6e-72, 80% identity YP_613762.1 PFAM: molybdopterin binding domain: (0.00035); KEGG: sil:SPO2639 molybdopterin biosynthesis protein, ev=1e-104, 57% identity YP_613763.1 PFAM: protein of unknown function DUF182: (7.8e-27); KEGG: sil:SPO2640 XdhC/CoxI family protein, ev=1e-131, 73% identity YP_613764.1 PFAM: VWA containing CoxE-like: (2.1e-89); KEGG: sil:SPO2644 VWA domain containing CoxE-like family protein, ev=1e-173, 71% identity YP_613765.1 PFAM: ATPase associated with various cellular activities, AAA_5: (6.6e-12); SMART: ATPase: (2e-06); KEGG: sil:SPO2646 hypothetical protein, ev=1e-137, 82% identity YP_613766.1 KEGG: sil:SPO2647 hypothetical protein, ev=1e-144, 72% identity YP_613767.1 KEGG: sil:SPO2648 hypothetical protein, ev=2e-44, 44% identity YP_613768.1 KEGG: sil:SPO2649 hypothetical protein, ev=0.0, 60% identity YP_613769.1 KEGG: sil:SPO2651 glycosyl transferase, group 2 family protein, ev=1e-131, 64% identity YP_613770.1 KEGG: sil:SPO2652 hypothetical protein, ev=1e-120, 65% identity YP_613771.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_613772.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_613773.1 unwinds double stranded DNA YP_613774.1 KEGG: sil:SPO2670 alanine racemase, ev=1e-130, 67% identity; TIGRFAM: alanine racemase: (8.8e-50); PFAM: alanine racemase-like: (3.9e-55) YP_613775.1 PFAM: protein of unknown function DUF140: (1.4e-87); KEGG: sil:SPO2671 membrane protein, ev=1e-117, 83% identity YP_613776.1 PFAM: ABC transporter related: (9.4e-51); SMART: ATPase: (2.8e-14); KEGG: sil:SPO2672 ABC transporter, ATP-binding protein, ev=1e-116, 85% identity YP_613778.1 PFAM: Paraquat-inducible protein A: (5.2e-07); KEGG: sil:SPO2673 paraquat-inducible protein A, , ev=2e-60, 78% identity YP_613779.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_613780.1 PFAM: Colicin V production protein: (2e-21); KEGG: sil:SPO2675 CvpA family protein, ev=2e-73, 73% identity YP_613781.1 KEGG: sil:SPO2676 hypothetical protein, ev=7e-18, 35% identity YP_613782.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_613783.1 KEGG: bca:BCE1117 hypothetical protein, ev=2e-07, 27% identity YP_613784.1 KEGG: sil:SPO2678 hypothetical protein, ev=2e-07, 35% identity YP_613785.1 PFAM: short-chain dehydrogenase/reductase SDR: (3.8e-09); KEGG: sil:SPO2679 oxidoreductase, short-chain dehydrogenase/reductase family, ev=2e-86, 76% identity YP_613786.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_613787.1 KEGG: sil:SPO2687 protein-L-isoaspartate O-methyltransferase, ev=8e-98, 83% identity; TIGRFAM: protein-L-isoaspartate O-methyltransferase: (6.2e-60); PFAM: protein-L-isoaspartate(D-aspartate) O-methyltransferase: (1.2e-59) Methyltransferase type 11: (0.0017) YP_613788.1 PFAM: Peptidoglycan-binding LysM: (4.3e-14) peptidase M23B: (6e-21); KEGG: sil:SPO2686 LysM domain/M23/M37 peptidase, ev=1e-131, 64% identity YP_613789.1 PFAM: protein of unknown function DUF815: (1.1e-60); KEGG: sil:SPO2680 hypothetical protein, ev=1e-139, 85% identity YP_613790.1 TIGRFAM: Sec-independent protein translocase TatC: (7.5e-64); PFAM: Sec-independent periplasmic protein translocase: (2.9e-60); KEGG: sil:SPO2681 twin-arginine translocation protein TatC, ev=1e-144, 89% identity YP_613791.1 TIGRFAM: twin-arginine translocation protein TatB: (1.6e-23); PFAM: sec-independent translocation protein mttA/Hcf106: (8.7e-05); KEGG: sil:SPO2682 twin-arginine translocation protein TatB, ev=5e-54, 71% identity YP_613792.1 PFAM: sec-independent translocation protein mttA/Hcf106: (2.5e-06); KEGG: sil:SPO2683 twin-arginine translocation protein, TatA/E family, ev=1e-27, 84% identity YP_613793.1 KEGG: sil:SPO2684 hypothetical protein, ev=1e-23, 53% identity YP_613794.1 PFAM: Helix-turn-helix, type 11: (3.8e-17); KEGG: sil:SPO2685 hypothetical protein, ev=1e-100, 83% identity YP_613795.1 PFAM: GCN5-related N-acetyltransferase: (6.7e-12); KEGG: syn:sll1469 hypothetical protein, ev=5e-70, 47% identity YP_613796.1 PFAM: ABC transporter related: (4.8e-60) Transport-associated OB: (8.4e-08); SMART: ATPase: (2.2e-22); KEGG: sil:SPO2689 iron ABC transporter, ATP-binding protein, , ev=1e-168, 81% identity YP_613797.1 KEGG: sil:SPO2691 hypothetical protein, ev=1e-125, 61% identity YP_613798.1 PFAM: short-chain dehydrogenase/reductase SDR: (2.9e-13); KEGG: sil:SPO2692 oxidoreductase, short chain dehydrogenase/reductase family, ev=1e-112, 77% identity YP_613799.1 KEGG: sil:SPO2693 hypothetical protein, ev=2e-97, 53% identity YP_613801.1 PFAM: protein of unknown function DUF883, ElaB: (1.3e-05); KEGG: bmb:BruAb1_1648 hypothetical protein, ev=9e-07, 32% identity YP_613802.1 TIGRFAM: peptide chain release factor 3: (2.8e-226) Small GTP-binding protein domain: (3.3e-17); PFAM: protein synthesis factor, GTP-binding: (3.7e-54) elongation factor Tu, domain 2: (2.2e-07); KEGG: sil:SPO2695 peptide chain release factor 3, ev=0.0, 91% identity YP_613803.1 KEGG: sil:SPO1444 hypothetical protein, ev=1e-92, 54% identity YP_613804.1 PFAM: helicase-like: (2.3e-36) DEAD/DEAH box helicase-like: (6.8e-68); KEGG: sil:SPO1443 ATP-dependent RNA helicase RhlE, ev=0.0, 75% identity YP_613806.1 TIGRFAM: TRAP dicarboxylate transporter- DctM subunit: (8.4e-163); PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (2.1e-137); KEGG: sil:SPO2626 TRAP transporter, DctM subunit, ev=0.0, 81% identity YP_613807.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component: (1.4e-43); KEGG: sil:SPO2627 TRAP transporter, DctQ subunit, ev=1e-69, 58% identity YP_613808.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit: (4.9e-85); PFAM: TRAP dicarboxylate transporter- DctP subunit: (3.4e-124); KEGG: sil:SPO2628 TRAP transporter solute receptor, DctP family, ev=1e-160, 84% identity YP_613809.1 PFAM: response regulator receiver: (1.8e-31) sigma-54 factor, interaction region: (6.1e-23) helix-turn-helix, Fis-type: (1.1e-08); KEGG: sil:SPO2629 C4-dicarboxylate transport transcriptional regulatory protein, ev=1e-161, 71% identity YP_613810.1 PFAM: ATP-binding region, ATPase-like: (7.1e-25) histidine kinase A-like: (2.4e-14); KEGG: sil:SPO2630 C4-dicarboxylate transport sensor protein, ev=0.0, 65% identity YP_613811.1 PFAM: cytochrome P450: (3.7e-09); KEGG: jan:Jann_1726 cytochrome P450, ev=1e-130, 61% identity YP_613812.1 KEGG: sil:SPO2988 hypothetical protein, ev=1e-176, 77% identity YP_613813.1 KEGG: sil:SPO2990 hypothetical protein, ev=1e-145, 67% identity YP_613814.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_613815.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.0088); PFAM: extracellular solute-binding protein, family 5: (7.9e-79); KEGG: mlo:mll5127 ABC transporter, binding protein, ev=0.0, 62% identity YP_613816.1 PFAM: binding-protein-dependent transport systems inner membrane component: (4.5e-45); KEGG: sil:SPO2996 peptide/nickel/opine uptake family ABC transporter, permease protein, ev=1e-138, 77% identity YP_613817.1 PFAM: binding-protein-dependent transport systems inner membrane component: (3.4e-35); KEGG: sil:SPO2997 peptide/nickel/opine uptake family ABC transporter, permease protein, ev=1e-127, 84% identity YP_613818.1 PFAM: ABC transporter related: (1e-55); SMART: ATPase: (1.5e-21); KEGG: sil:SPO2998 peptide/nickel/opine uptake family ABC transporter, ATP-binding protein, ev=0.0, 88% identity YP_613819.1 KEGG: sil:SPO3000 hypothetical protein, ev=1e-146, 87% identity YP_613820.1 KEGG: sil:SPO3001 hypothetical protein, ev=2e-51, 52% identity YP_613821.1 PFAM: Alpha/beta hydrolase fold-3: (2.2e-72); KEGG: sil:SPO3002 lipase, , ev=6e-99, 58% identity YP_613822.1 activates fatty acids by binding to coenzyme A YP_613823.1 KEGG: sil:SPO3005 ABC transporter, ATP binding/permease protein, ev=0.0, 77% identity; TIGRFAM: ABC transporter, ATP-binding/permease protein: (0); PFAM: ABC transporter, transmembrane region: (2.2e-35) ABC transporter related: (1.4e-70); SMART: ATPase: (2.1e-23) YP_613824.1 KEGG: hch:HCH_01550 hypothetical protein, ev=2e-50, 37% identity YP_613826.1 PFAM: protein of unknown function DUF900, hydrolase-like: (8.7e-23); KEGG: rso:RSc0827 hypothetical protein, ev=6e-27, 32% identity YP_613827.1 KEGG: bja:bll3105 hypothetical protein, ev=1e-128, 45% identity YP_613829.1 KEGG: bja:bll7673 hypothetical protein, ev=1e-33, 34% identity YP_613830.1 PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein: (3.4e-07); KEGG: sil:SPO2745 hypothetical protein, ev=6e-52, 47% identity YP_613831.1 PFAM: glutamine synthetase, catalytic region: (2.3e-96); KEGG: rsp:RSP_0375 probable glutamine synthetase, ev=1e-153, 61% identity YP_613832.1 KEGG: sil:SPO1301 glutamine amidotransferase, class I, ev=1e-82, 63% identity YP_613833.1 PFAM: glutamine synthetase, catalytic region: (5.5e-94); KEGG: sil:SPO1300 glutamine synthetase family protein, ev=0.0, 88% identity YP_613834.1 PFAM: FAD dependent oxidoreductase: (3.7e-96); KEGG: rsp:RSP_0378 hypothetical protein, ev=1e-150, 62% identity YP_613835.1 PFAM: DegT/DnrJ/EryC1/StrS aminotransferase: (1.1e-50) aminotransferase, class I and II: (5.8e-05); KEGG: sil:SPO1295 aminotransferase, DegT/DnrJ/EryC1/StrS family, ev=0.0, 80% identity YP_613836.1 TIGRFAM: Polyhydroxyalkanoate synthesis repressor PhaR: (7e-66); PFAM: PHB accumulation regulatory: (5.5e-09) PHA accumulation regulator DNA-binding-like: (1.1e-39); KEGG: sil:SPO1294 polyhydroxyalkanoate synthesis repressor PhaR, ev=1e-84, 84% identity YP_613837.1 KEGG: sil:SPO1293 phasin, PhaP, ev=2e-60, 81% identity YP_613839.1 KEGG: sil:SPO1128 hypothetical protein, ev=3e-84, 67% identity YP_613840.1 PFAM: ABC transporter related: (8.3e-58); SMART: ATPase: (5.4e-16); KEGG: sil:SPO1124 lipoprotein releasing system ATP-binding protein, ev=1e-93, 78% identity YP_613841.1 TIGRFAM: Lipoprotein releasing system, transmembrane protein, LolC/E family: (9.8e-135); PFAM: protein of unknown function DUF214: (5.5e-40); KEGG: sil:SPO1123 lipoprotein releasing system transmembrane protein LolE, ev=0.0, 76% identity YP_613842.1 KEGG: ret:RHE_CH03836 hypothetical protein, ev=4e-18, 39% identity YP_613843.1 PFAM: thioesterase superfamily: (9.8e-06); KEGG: bja:blr1345 hypothetical protein, ev=2e-11, 31% identity YP_613845.1 PFAM: bifunctional deaminase-reductase-like: (1.6e-07); KEGG: jan:Jann_2049 bifunctional deaminase-reductase-like, ev=4e-62, 62% identity YP_613847.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_613849.1 PFAM: response regulator receiver: (5.7e-18) GAF: (1.2e-16) ATP-binding region, ATPase-like: (2.8e-39) histidine kinase A-like: (2.1e-21); KEGG: ccr:CC2988 sensor histidine kinase/response regulator, ev=2e-61, 38% identity YP_613850.1 PFAM: protein of unknown function UPF0118: (2.7e-50); KEGG: sil:SPO1119 membrane protein, ev=1e-136, 65% identity YP_613851.1 PFAM: Chromosomal replication initiator, DnaA: (0.0011); KEGG: sil:SPO1118 hypothetical protein, ev=1e-77, 66% identity YP_613852.1 PFAM: Ppx/GppA phosphatase: (9.9e-28); KEGG: sil:SPO1117 phosphatase, Ppx/GppA family, ev=0.0, 73% identity YP_613853.1 KEGG: rsp:RSP_6229 hypothetical protein, ev=1e-15, 39% identity YP_613854.1 PFAM: Endonuclease/exonuclease/phosphatase: (8e-05); KEGG: sil:SPO1109 endonuclease/exonuclease/phosphatase family protein, ev=1e-106, 59% identity YP_613855.1 PFAM: heat shock protein DnaJ-like: (9.2e-06); KEGG: sil:SPO1108 DnaJ-like protein DjlA, , ev=1e-94, 73% identity YP_613856.1 PFAM: GCN5-related N-acetyltransferase: (2e-17); KEGG: sil:SPO1107 phosphinothricin N-acetyltransferase, , ev=5e-37, 54% identity YP_613857.1 KEGG: sil:SPO1106 hypothetical protein, ev=3e-68, 66% identity YP_613858.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (3.2e-11); KEGG: sil:SPOA0321 glyoxalase family protein, ev=9e-45, 59% identity YP_613859.1 KEGG: atc:AGR_L_680 hypothetical protein, ev=1e-08, 65% identity YP_613860.1 MDM; functions in conversion of succinate to propionate YP_613861.1 KEGG: sil:SPO1104 hypothetical protein, ev=3e-87, 53% identity YP_613862.1 KEGG: sil:SPO1103 hypothetical protein, ev=1e-34, 61% identity YP_613863.1 KEGG: sil:SPO1102 lipoprotein, , ev=2e-30, 40% identity YP_613864.1 PFAM: biotin/lipoyl attachment: (2.7e-18) ATP-dependent carboxylate-amine ligase-like, ATP-grasp: (0.00035) Carbamoyl-phosphate synthase L chain, ATP-binding: (5.6e-115) Carbamoyl-phosphate synthetase large chain-like: (1.6e-48) biotin carboxylase-like: (6e-56) RimK-like ATP-grasp: (0.00016); KEGG: sil:SPO1101 propionyl-CoA carboxylase, alpha subunit, ev=0.0, 86% identity YP_613865.1 KEGG: sil:SPO1100 lipoprotein, , ev=1e-11, 55% identity YP_613867.1 KEGG: sil:SPO1097 hypothetical protein, ev=3e-52, 82% identity YP_613868.1 KEGG: sil:SPO1096 lipoprotein, , ev=8e-08, 59% identity YP_613869.1 KEGG: rsp:RSP_6040 hypothetical protein, ev=2e-15, 41% identity YP_613870.1 KEGG: sil:SPO1095 hypothetical protein, ev=2e-23, 65% identity YP_613872.1 PFAM: carboxyl transferase: (2.3e-287); KEGG: sil:SPO1094 propionyl-CoA carboxylase, beta subunit, ev=0.0, 91% identity YP_613873.1 TIGRFAM: Drug resistance transporter Bcr/CflA subfamily: (9.4e-44); PFAM: major facilitator superfamily MFS_1: (1.5e-44); KEGG: sil:SPO1093 drug resistance transporter, Bcr/CflA family, ev=1e-143, 63% identity YP_613874.1 PFAM: helix-turn-helix motif: (1e-14) protein of unknown function DUF955: (3e-15); KEGG: sil:SPO1090 DNA-binding protein, , ev=0.0, 82% identity YP_613875.1 PFAM: protein of unknown function DUF465: (2.7e-05); KEGG: sil:SPO1089 hypothetical protein, ev=1e-32, 84% identity YP_613877.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_613878.1 catalyzes the formation of betaine from betaine aldehyde YP_613879.1 KEGG: sil:SPO1087 membrane protein, , ev=1e-165, 70% identity YP_613880.1 PFAM: regulatory protein, TetR: (1e-13); KEGG: sil:SPO1086 transcriptional regulator, TetR family, ev=4e-54, 54% identity YP_613881.1 KEGG: sil:SPO1081 hypothetical protein, ev=2e-17, 37% identity YP_613882.1 PFAM: protein of unknown function DUF6, transmembrane: (0.00035); KEGG: sil:SPO1080 membrane protein, , ev=1e-106, 64% identity YP_613883.1 PFAM: ABC transporter related: (1.1e-30); SMART: ATPase: (3.2e-17); KEGG: rru:Rru_A0047 ABC transporter component, ev=1e-162, 59% identity YP_613884.1 PFAM: Pirin-like: (3e-57); KEGG: sil:SPO2601 pirin domain protein, ev=1e-126, 69% identity YP_613885.1 PFAM: Lysine exporter protein (LYSE/YGGA): (3.4e-54); KEGG: sil:SPO1079 L-lysine exporter, , ev=6e-68, 66% identity YP_613886.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_613887.1 KEGG: rso:RS03125 probable transmembrane protein, ev=6e-13, 25% identity YP_613888.2 PFAM: protein of unknown function DUF28: (4.3e-147); KEGG: sil:SPO1072 conserved hypothetical protein TIGR01033, ev=1e-123, 89% identity YP_613890.1 PFAM: Citrate transporter: (3.1e-06) TrkA-C: (1.9e-06); KEGG: sil:SPO1076 trkA-C domain protein, ev=0.0, 79% identity YP_613891.1 proposed role in polysaccahride synthesis YP_613892.1 TIGRFAM: conserved hypothetical protein: (1.7e-48); KEGG: jan:Jann_2797 hypothetical protein, ev=3e-59, 73% identity YP_613893.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.15); PFAM: protein of unknown function DUF306, Meta and HslJ: (9.4e-21); KEGG: sil:SPO2951 hypothetical protein, ev=9e-14, 41% identity YP_613894.1 PFAM: Citrate transporter: (7.1e-07) TrkA-C: (1.9e-11); KEGG: sil:SPO2952 TrkA domain protein, ev=0.0, 84% identity YP_613895.1 PFAM: beta-lactamase: (1.6e-37); KEGG: jan:Jann_2001 beta-lactamase, ev=2e-84, 56% identity YP_613896.1 TIGRFAM: conserved hypothetical protein: (1.2e-74); PFAM: metallophosphoesterase: (4.8e-06); KEGG: sil:SPO2953 Ser/Thr protein phosphatase family protein, ev=1e-125, 80% identity YP_613897.1 KEGG: ana:alr5242 hypothetical protein, ev=1e-16, 30% identity YP_613898.1 PFAM: 5-formyltetrahydrofolate cyclo-ligase: (5.9e-26); KEGG: sil:SPO2954 5-formyltetrahydrofolate cyclo-ligase family protein, ev=2e-82, 83% identity YP_613899.1 TIGRFAM: magnesium transporter: (7.8e-92); PFAM: CBS: (2.2e-18) MgtE integral membrane region: (8e-23) MgtE intracellular region: (3.4e-35); KEGG: sil:SPO2955 magnesium transporter, ev=0.0, 77% identity YP_613900.1 Catalyzes the deamination of guanine YP_613901.1 catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway. YP_613902.1 TIGRFAM: Histidinol-phosphate phosphatase, , inositol monophosphatase: (2e-108); PFAM: inositol monophosphatase: (3.9e-58); KEGG: sil:SPO2958 inositol monophosphatase family protein, ev=1e-99, 69% identity YP_613904.1 PFAM: helix-turn-helix motif: (4e-13); KEGG: sil:SPO2959 DNA-binding protein, , ev=4e-56, 86% identity YP_613905.1 PFAM: Alcohol dehydrogenase, zinc-binding: (1e-38) Alcohol dehydrogenase GroES-like: (4.6e-19); KEGG: sil:SPO2960 oxidoreductase, zinc-binding dehydrogenase family, ev=1e-117, 65% identity YP_613906.1 PFAM: regulatory protein, LysR: (6.6e-20) LysR, substrate-binding: (8e-10); KEGG: sil:SPO2961 transcriptional regulator, LysR family, ev=4e-96, 60% identity YP_613907.1 PFAM: protein of unknown function DUF1127: (2.6e-07); KEGG: sil:SPO2962 hypothetical protein, ev=6e-09, 51% identity YP_613908.1 PFAM: protein of unknown function UPF0005: (9.6e-13); KEGG: sil:SPO2963 membrane protein, , ev=1e-116, 82% identity YP_613909.1 PFAM: GCN5-related N-acetyltransferase: (6.5e-09) YP_613910.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_613911.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2: (9.5e-43); KEGG: sil:SPO2967 N-acetylmuramoyl-L-alanine amidase, , ev=2e-86, 72% identity YP_613912.1 KEGG: sil:SPO2968 hypothetical protein, ev=6e-74, 56% identity YP_613913.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_613914.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_613915.1 PFAM: beta-lactamase-like: (3.5e-11); KEGG: sil:SPO2976 metallo-beta-lactamase family protein, ev=1e-104, 76% identity YP_613916.1 PFAM: peptidase M24: (3.8e-06); KEGG: ret:RHE_PF00180 probable peptidase protein, ev=1e-116, 52% identity YP_613917.1 PFAM: methyladenine glycosylase: (1.9e-78); KEGG: sil:SPO1900 DNA-3-methyladenine glycosylase I, ev=3e-74, 69% identity YP_613918.1 PFAM: YCII-related: (6.8e-09); KEGG: hch:HCH_03235 hypothetical protein, ev=4e-16, 43% identity YP_613919.1 PFAM: regulatory protein, TetR: (1.3e-17); KEGG: sil:SPO1902 transcription regulator, TetR family, ev=6e-52, 58% identity YP_613921.1 PFAM: CMP/dCMP deaminase, zinc-binding: (2.6e-33); KEGG: sil:SPO2983 cytidine and deoxycytidylate deaminase family protein, ev=1e-58, 76% identity YP_613922.1 TIGRFAM: Pseudouridine synthase, Rsu: (6e-43); PFAM: RNA-binding S4: (8.5e-13) pseudouridine synthase: (1.3e-09); KEGG: sil:SPO2984 RNA pseudouridylate synthase family protein, ev=1e-113, 63% identity YP_613923.1 KEGG: sil:SPO2985 hypothetical protein, ev=5e-93, 59% identity YP_613924.1 PFAM: toxic anion resistance: (4.7e-146); KEGG: sil:SPO2986 tellurite resistance protein, ev=1e-177, 82% identity YP_613925.1 KEGG: sil:SPO2987 lipoprotein, , ev=2e-78, 53% identity YP_613926.1 PFAM: glutathione S-transferase-like: (9.1e-06); KEGG: eba:ebA3377 glutathione-S-transferase-related protein, ev=2e-62, 58% identity YP_613927.1 PFAM: thiamine pyrophosphate enzyme-like TPP-binding: (4.4e-55) thiamine pyrophosphate enzyme, central region: (6.3e-07) thiamine pyrophosphate enzyme-like TPP binding region: (6.9e-54); KEGG: bms:BRA0945 acetolactate synthase large subunit, ev=1e-177, 55% identity YP_613928.1 TIGRFAM: Phosphoenolpyruvate-protein phosphotransferase: (1.1e-75); PFAM: PEP-utilizing enzyme: (1.2e-82) GAF: (6.5e-18) PEP-utilising enzyme, mobile region: (1.9e-10) PEP-utilising enzyme-like: (3e-19); KEGG: sil:SPO3034 phosphoenolpyruvate-protein phosphotransferase, ev=0.0, 84% identity YP_613929.1 KEGG: sil:SPO3035 aspartate kinase, monofunctional class, ev=0.0, 87% identity; TIGRFAM: aspartate kinase: (3.9e-173) aspartate kinase, monofunctional class: (1.3e-133); PFAM: aspartate/glutamate/uridylate kinase: (2.4e-62) amino acid-binding ACT: (2.2e-10) YP_613930.1 PFAM: cation transporter: (3.3e-39); KEGG: sil:SPO1353 trk system potassium uptake protein TrkH, ev=0.0, 76% identity YP_613931.1 KEGG: lma:LmjF35.0290 hypothetical protein, conserved, ev=2e-18, 37% identity YP_613932.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis YP_613933.1 KEGG: sil:SPO1351 O-succinylhomoserine sulfhydrylase, ev=0.0, 83% identity; TIGRFAM: O-succinylhomoserine sulfhydrylase: (6.7e-214); PFAM: aminotransferase, class V: (0.00042) Cys/Met metabolism pyridoxal-phosphate-dependent enzymes: (3.2e-172) aromatic amino acid beta-eliminating lyase/threonine aldolase: (0.00048) YP_613935.1 PFAM: Intracellular septation protein A: (1.4e-47); KEGG: rsp:RSP_1841 probable intracellular septation protein, ev=1e-76, 65% identity YP_613936.1 PFAM: protein of unknown function DUF6, transmembrane: (1.5e-09); KEGG: sil:SPO1337 membrane protein, , ev=1e-140, 83% identity YP_613937.1 KEGG: rsp:RSP_1843 signal recognition particle-docking protein FtsY, ev=1e-155, 74% identity; TIGRFAM: signal recognition particle-docking protein FtsY: (2.7e-132); PFAM: GTP-binding signal recognition particle SRP54, G-domain: (3e-105); SMART: ATPase: (7.7e-13) YP_613938.1 PFAM: YhhN-like: (7.7e-29); KEGG: sil:SPO1340 membrane protein, , ev=1e-42, 51% identity YP_613939.1 KEGG: sil:SPO1342 hypothetical protein, ev=9e-31, 50% identity YP_613940.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_613941.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_613942.1 KEGG: jan:Jann_3167 integrins alpha chain, ev=6e-54, 50% identity YP_613943.1 PFAM: ferredoxin: (6e-14); KEGG: sil:SPO1348 iron-sulfur cluster-binding protein, ev=1e-54, 92% identity YP_613944.1 PFAM: Peptidoglycan-binding domain 1: (0.00064); KEGG: sil:SPO1349 lipoprotein, , ev=5e-37, 51% identity YP_613945.1 PFAM: cyclic nucleotide-binding: (1.9e-24) regulatory protein, Crp: (4e-07); KEGG: sil:SPO1335 transcriptional regulator, Crp/Fnr family, ev=2e-70, 61% identity YP_613946.1 PFAM: Tetratricopeptide TPR_2: (0.0012); KEGG: sme:SMc03099 adenylate cyclase protein, ev=4e-45, 30% identity YP_613947.1 TIGRFAM: Peptidase S1C, Do: (4.1e-174); PFAM: peptidase S1 and S6, chymotrypsin/Hap: (3.8e-24) PDZ/DHR/GLGF: (1.9e-05); KEGG: sil:SPO1333 periplasmic serine protease, DO/DeqQ family, ev=0.0, 76% identity YP_613949.1 TIGRFAM: HflC protein: (1.9e-47); PFAM: band 7 protein: (7.4e-34); KEGG: sil:SPO1330 HflC protein, ev=1e-125, 78% identity YP_613950.1 TIGRFAM: HflK protein: (2.4e-84); PFAM: band 7 protein: (3.4e-25); KEGG: sil:SPO1329 HflK protein, ev=1e-163, 75% identity YP_613951.1 TIGRFAM: Glutathione reductase, plant: (2.8e-243); PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (1.1e-21) pyridine nucleotide-disulphide oxidoreductase dimerisation region: (1.4e-44); KEGG: sil:SPO1328 glutathione-disulfide reductase, ev=0.0, 82% identity YP_613953.1 PFAM: transmembrane pair: (1.2e-30); KEGG: atc:AGR_C_3030 hypothetical protein PA2880, ev=6e-52, 66% identity YP_613954.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_613955.1 PFAM: glutathione S-transferase-like: (1.5e-12); KEGG: sil:SPO1324 glutathione S-transferase family protein, ev=1e-67, 55% identity YP_613956.1 KEGG: sil:SPO1323 L-serine ammonia-lyase, ev=0.0, 88% identity; TIGRFAM: L-serine dehydratase 1: (1.8e-213); PFAM: serine dehydratase alpha chain: (3.3e-146) serine dehydratase beta chain: (7.8e-49) YP_613957.1 PFAM: regulatory protein, TetR: (2.4e-13); KEGG: sil:SPO3545 transcriptional regulator, TetR family, ev=2e-29, 40% identity YP_613958.1 KEGG: sil:SPO3544 hypothetical protein, ev=6e-61, 42% identity YP_613959.1 PFAM: protein of unknown function DUF6, transmembrane: (6.5e-10); KEGG: sil:SPO1322 membrane protein, , ev=3e-95, 62% identity YP_613960.1 TIGRFAM: thiamine pyrophosphokinase: (3e-22); PFAM: Thiamin pyrophosphokinase, catalytic region: (1.4e-20); KEGG: sil:SPO1321 thiamine pyrophosphokinase, ev=2e-55, 53% identity YP_613961.1 KEGG: sil:SPO1320 lipoprotein, , ev=1e-125, 42% identity YP_613962.1 KEGG: rsp:RSP_6113 hypothetical protein, ev=3e-19, 60% identity YP_613963.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_613964.1 KEGG: sil:SPO1316 hypothetical protein, ev=6e-35, 65% identity YP_613965.1 KEGG: sil:SPO1315 nitrile hydratase beta subunit, ev=1e-77, 64% identity YP_613966.1 KEGG: sil:SPO1314 nitrile hydratase subunit alpha, ev=1e-96, 84% identity; TIGRFAM: nitrile hydratase, alpha subunit: (3.2e-107); PFAM: Nitrile hydratase alpha chain: (3.5e-111) YP_613967.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_613969.1 KEGG: sil:SPO3023 hypothetical protein, ev=1e-37, 70% identity YP_613970.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis YP_613971.1 PFAM: chemotaxis sensory transducer: (6.5e-74); KEGG: nar:Saro_1430 methyl-accepting chemotaxis sensory transducer, ev=2e-86, 38% identity YP_613973.1 PFAM: fatty acid hydroxylase: (3.1e-07); KEGG: bce:BC1607 fatty acid hydroxylase FAH1P, ev=8e-20, 30% identity YP_613974.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_613975.1 catalyzes the formation of histidinol phosphate and 2-oxoglutarate from glutamate and imidazole acetol-phosphate YP_613977.1 PFAM: aminotransferase, class V: (9.1e-10); KEGG: sil:SPO3029 serine--glyoxylate transaminase, , ev=1e-169, 71% identity YP_613978.1 PFAM: ABC transporter, transmembrane region: (1e-19) ABC transporter related: (1.4e-65); SMART: ATPase: (2.8e-20); KEGG: sil:SPO3030 efflux ABC transporter, transmembrane ATP-binding protein, ev=0.0, 67% identity YP_613979.1 PFAM: glycine cleavage T protein (aminomethyl transferase): (3.5e-12); KEGG: sil:SPO1246 aminomethyl transferase family protein, ev=1e-89, 69% identity YP_613981.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_613982.1 KEGG: sil:SPO1243 hypothetical protein, ev=1e-51, 96% identity YP_613983.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_613984.1 KEGG: sil:SPO1241 hypothetical protein, ev=2e-28, 32% identity YP_613985.1 TIGRFAM: Type I secretion outer membrane protein, TolC: (3.5e-56); PFAM: outer membrane efflux protein: (4e-24); KEGG: sil:SPO1240 type I secretion outer membrane protein, TolC family, ev=1e-129, 55% identity YP_613986.1 PFAM: protein-L-isoaspartate(D-aspartate) O-methyltransferase: (5.5e-11) methyltransferase small: (0.00034) Methyltransferase type 11: (0.0012); KEGG: sil:SPO1239 protein-L-isoaspartate O-methyltransferase, ev=1e-75, 64% identity YP_613987.1 KEGG: rsp:RSP_0166 DnaK suppressor protein, ev=8e-06, 45% identity YP_613988.1 PFAM: Entericidin EcnAB: (1e-08) YP_613989.1 PFAM: GAF: (9.7e-13) PAS fold-3: (4.1e-05) PAS fold-4: (5.2e-08) PAS fold: (5.1e-12); SMART: PAS: (1.3e-08) PAC motif: (5.5e-07); KEGG: ilo:IL2487 intracellular signaling protein (PAS,GAF,GGDEF domains), ev=3e-35, 33% identity YP_613991.1 PFAM: ATP-binding region, ATPase-like: (2.3e-31) histidine kinase A-like: (1.8e-07) CHASE: (7.2e-18); KEGG: cps:CPS_3952 sensor histidine kinase, ev=1e-108, 37% identity YP_613992.1 PFAM: response regulator receiver: (4.5e-19); KEGG: cps:CPS_3951 response regulator, ev=1e-26, 45% identity YP_613994.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.016); PFAM: Amidohydrolase 3: (2.2e-17); KEGG: sil:SPO0955 amidohydrolase domain protein, ev=0.0, 65% identity YP_613995.1 KEGG: jan:Jann_2370 hypothetical protein, ev=3e-11, 41% identity YP_613996.1 PFAM: chemotaxis sensory transducer: (3e-80); SMART: Histidine kinase, HAMP region: (5.1e-08); KEGG: ccr:CC2847 methyl-accepting chemotaxis protein McpI, ev=1e-97, 42% identity YP_613997.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase: (0.001) 6-phosphogluconate dehydrogenase, NAD-binding: (7.5e-42); KEGG: sil:SPO2859 3-hydroxyisobutyrate dehydrogenase family protein, ev=1e-143, 80% identity YP_613998.1 PFAM: regulatory protein, LysR: (3.5e-19) LysR, substrate-binding: (1.3e-20); KEGG: sil:SPOA0284 transcriptional regulator, LysR family, ev=6e-64, 48% identity YP_613999.1 PFAM: regulatory protein, LysR: (4.3e-21) LysR, substrate-binding: (5.4e-21); KEGG: bur:Bcep18194_C7696 transcriptional regulator, LysR family, ev=1e-39, 34% identity YP_614000.1 PFAM: Taurine catabolism dioxygenase TauD/TfdA: (8.8e-25); KEGG: pfo:Pfl_5234 gamma-butyrobetaine hydroxylase, ev=8e-54, 34% identity YP_614001.1 PFAM: class II aldolase/adducin-like: (4.5e-34); KEGG: aci:ACIAD3485 hypothetical protein, ev=2e-56, 46% identity YP_614002.1 PFAM: helix-turn-helix, HxlR type: (1.2e-13); KEGG: eli:ELI_10910 hypothetical protein, ev=1e-19, 37% identity YP_614003.1 KEGG: ccr:CC0038 dienelactone hydrolase family protein, ev=8e-49, 42% identity YP_614004.1 PFAM: ATP-binding region, ATPase-like: (6.9e-16) histidine kinase A-like: (4.1e-08) PAS fold-4: (7.4e-07); KEGG: jan:Jann_3638 histidine kinase, ev=3e-24, 28% identity YP_614005.1 KEGG: mag:amb1751 site-specific DNA methylase, ev=5e-07, 46% identity YP_614008.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_614009.1 PFAM: methyltransferase: (5.6e-97); KEGG: sil:SPO1179 S-adenosyl-methyltransferase MraW, ev=1e-137, 76% identity YP_614010.1 KEGG: sil:SPO1180 hypothetical protein, ev=5e-34, 63% identity YP_614011.1 PFAM: penicillin-binding protein, transpeptidase: (5.9e-58) Penicillin-binding protein, dimerisation domain: (1.8e-18); KEGG: sil:SPO1181 penicillin-binding protein, ev=0.0, 73% identity YP_614012.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_614013.1 TIGRFAM: UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase: (1.6e-125); PFAM: cytoplasmic peptidoglycan synthetase-like: (1.1e-18) cytoplasmic peptidoglycan synthetases-like: (0.0018) Mur ligase, middle region: (2e-49); KEGG: sil:SPO1183 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase, ev=1e-178, 70% identity YP_614014.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_614016.1 KEGG: rsp:RSP_2093 Mrp (multidrug resistance-associated proteins) family protein, ev=1e-138, 69% identity YP_614017.1 PFAM: protein of unknown function DUF1127: (1.1e-06); KEGG: sil:SPO1177 hypothetical protein, ev=3e-12, 69% identity YP_614018.1 PFAM: UvrD/REP helicase: (7.9e-183); KEGG: sil:SPO1174 DNA helicase II, , ev=0.0, 78% identity YP_614019.1 PFAM: BLUF: (7.6e-22); KEGG: cef:CE2367 hypothetical protein, ev=1e-13, 38% identity YP_614020.1 PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase: (7.6e-99); KEGG: sil:SPO1172 FMN-dependent alpha-hydroxy acid dehydrogenase family protein, ev=1e-145, 69% identity YP_614021.1 PFAM: BLUF: (2.8e-13); KEGG: jan:Jann_2780 BLUF, ev=2e-17, 35% identity YP_614022.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_614024.1 KEGG: sil:SPO3765 hypothetical protein, ev=1e-50, 62% identity YP_614025.1 PFAM: aminotransferase class-III: (6.9e-87); KEGG: sil:SPO1166 aminotransferase, class III family, ev=0.0, 82% identity YP_614026.1 PFAM: regulatory proteins, AsnC/Lrp: (8.2e-12); KEGG: sil:SPO1164 hypothetical protein, ev=7e-36, 91% identity YP_614027.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_614028.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_614029.1 PFAM: helix-turn-helix, AraC type: (0.00031); KEGG: sil:SPO1161 transcriptional regulator, AraC family, ev=4e-70, 61% identity YP_614030.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen: (0.00026) Redoxin: (1.9e-10); KEGG: sil:SPO1160 hypothetical protein, ev=4e-80, 79% identity YP_614032.1 KEGG: jan:Jann_2791 hypothetical protein, ev=8e-40, 56% identity YP_614033.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_614034.1 KEGG: sil:SPO1157 hypothetical protein, ev=5e-55, 70% identity YP_614035.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_614036.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_614037.1 PFAM: protein of unknown function DUF1006: (4.5e-85); KEGG: sil:SPO3685 hypothetical protein, ev=4e-83, 44% identity YP_614038.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis YP_614039.1 PFAM: Radical SAM: (0.0075); KEGG: sil:SPO3752 radical SAM domain protein, ev=8e-91, 68% identity YP_614040.1 PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein: (2.7e-09); KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein, ev=1e-48, 74% identity YP_614041.1 PFAM: ExsB: (5.9e-74); KEGG: sil:SPO3751 ExsB, ev=1e-104, 78% identity YP_614043.1 TIGRFAM: RNA methyltransferase TrmH, group 3: (6.2e-46); PFAM: tRNA/rRNA methyltransferase (SpoU): (7.5e-42) RNA 2-O ribose methyltransferase, substrate binding: (1.6e-07); KEGG: sil:SPO1150 RNA methyltransferase, TrmH family, group 3, ev=1e-116, 84% identity YP_614045.1 KEGG: sil:SPO1152 twin-arginine translocation pathway signal sequence domain protein, , ev=2e-29, 44% identity YP_614046.1 PFAM: CoA-binding: (8.3e-13); KEGG: sil:SPO1153 CoA-binding domain protein, ev=2e-66, 81% identity YP_614047.1 KEGG: sil:SPO1135 hypothetical protein, ev=2e-54, 60% identity YP_614048.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_614049.1 PFAM: LamB/YcsF: (1.9e-100); KEGG: sil:SPO3659 LamB/YcsF family protein, ev=5e-89, 64% identity YP_614050.1 PFAM: Allophanate hydrolase subunit 2: (1.1e-27); KEGG: sil:SPO3660 urea amidolyase, homolog, ev=1e-100, 58% identity YP_614051.1 PFAM: Allophanate hydrolase subunit 1: (9.4e-09); KEGG: sil:SPO3661 allophanate hydrolase family protein, ev=6e-78, 60% identity YP_614052.1 PFAM: regulatory protein, LysR: (1.3e-16) LysR, substrate-binding: (4.8e-32); KEGG: sme:SMa0750 probable LysR-family transcriptional activator, ev=2e-57, 40% identity YP_614053.1 PFAM: Rieske [2Fe-2S] region: (1.2e-23); KEGG: jan:Jann_1889 Rieske (2Fe-2S) protein, ev=1e-145, 61% identity YP_614055.1 PFAM: regulatory protein, LysR: (1.7e-19) LysR, substrate-binding: (1.6e-46); KEGG: sil:SPO2238 transcriptional regulator, LysR family, ev=3e-85, 56% identity YP_614056.1 PFAM: protein of unknown function DUF465: (1.7e-05); KEGG: sil:SPO2237 hypothetical protein, ev=8e-11, 43% identity YP_614057.1 PFAM: FAD dependent oxidoreductase: (2.9e-95) glycine cleavage T protein (aminomethyl transferase): (3.7e-40); KEGG: sme:SMa1483 dimethylglycine dehydrogenase, ev=0.0, 74% identity YP_614058.1 PFAM: FAD dependent oxidoreductase: (7.7e-55); KEGG: reu:Reut_A1655 D-amino-acid dehydrogenase, ev=5e-94, 44% identity YP_614059.1 PFAM: Endoribonuclease L-PSP: (1.8e-34); KEGG: sil:SPO2000 endoribonuclease L-PSP family protein, ev=2e-46, 75% identity YP_614060.1 PFAM: histone deacetylase superfamily: (5.8e-61); KEGG: sil:SPO2002 acetylpolyamine aminohydrolase, ev=1e-145, 72% identity YP_614061.1 TIGRFAM: TRAP dicarboxylate transporter- DctM subunit: (8.1e-81); PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (2.3e-73); KEGG: dps:DP0487 DctM (C4-dicarboxylate permease, large subunit), ev=4e-99, 42% identity YP_614062.1 KEGG: dps:DP3053 DctMQ fusion protein (C4-dicarboxylate transporter), ev=1e-06, 30% identity YP_614063.1 PFAM: TRAP dicarboxylate transporter- DctP subunit: (1.1e-09); KEGG: bbr:BB3954 periplasmic solute-binding transport protein, ev=3e-25, 28% identity YP_614064.1 PFAM: regulatory protein, MarR: (0.0018) regulatory protein, LysR: (2.5e-21) LysR, substrate-binding: (7.1e-34); KEGG: sil:SPO2010 transcriptional regulator, LysR family, ev=1e-114, 61% identity YP_614065.1 TIGRFAM: riboflavin biosynthesis protein RibF: (1.7e-78); PFAM: Riboflavin kinase / FAD synthetase: (2.6e-52); KEGG: sil:SPO3154 riboflavin biosynthesis protein RibF, ev=1e-143, 79% identity YP_614066.1 PFAM: Uncharacterised conserved protein UCP006173: (2.9e-82); KEGG: sil:SPO3155 hypothetical protein, ev=8e-74, 75% identity YP_614067.1 PFAM: alpha/beta hydrolase fold: (3.2e-05); KEGG: sil:SPO3157 hydrolase, alpha/beta fold family, ev=6e-70, 50% identity YP_614068.1 PFAM: DSBA oxidoreductase: (1.6e-27); KEGG: sil:SPO3158 2-hydroxychromene-2-carboxylate isomerase, ev=2e-83, 75% identity YP_614069.1 KEGG: sil:SPO3159 ribose-phosphate pyrophosphokinase, ev=1e-171, 90% identity; TIGRFAM: ribose-phosphate pyrophosphokinase: (3.4e-112); PFAM: phosphoribosyltransferase: (7.4e-30) YP_614070.1 PFAM: NAD-dependent epimerase/dehydratase: (5.7e-05) dTDP-4-dehydrorhamnose reductase: (1.4e-05) Male sterility-like: (0.0011); KEGG: ccr:CC2899 hypothetical protein, ev=1e-79, 41% identity YP_614071.1 KEGG: ret:RHE_CH02786 hypothetical conserved membrane protein, ev=5e-47, 61% identity YP_614072.1 PFAM: protein of unknown function DUF6, transmembrane: (4.4e-08); KEGG: jan:Jann_3630 protein of unknown function DUF6, transmembrane, ev=2e-67, 50% identity YP_614074.1 TIGRFAM: ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter: (1.5e-39) ATPase, P type cation/copper-transporter: (3.5e-231) Heavy metal translocating P-type ATPase: (8.1e-243); PFAM: Haloacid dehalogenase-like hydrolase: (1.5e-34) Heavy metal transport/detoxification protein: (1.4e-13) E1-E2 ATPase-associated region: (6.5e-98); KEGG: sil:SPO0794 copper-translocating P-type ATPase, ev=0.0, 61% identity YP_614075.1 PFAM: regulatory protein, MerR: (5.7e-11); KEGG: pfo:Pfl_0677 possible transcriptional regulator, MerR family, ev=8e-19, 43% identity YP_614076.1 KEGG: pfo:Pfl_0678 hypothetical protein, ev=8e-11, 32% identity YP_614078.1 KEGG: sil:SPO3160 hypothetical protein, ev=2e-30, 54% identity YP_614079.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex YP_614080.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_614081.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_614082.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_614083.1 TIGRFAM: ATP synthase F1, delta subunit: (2e-35); PFAM: H+-transporting two-sector ATPase, delta (OSCP) subunit: (1e-64); KEGG: sil:SPO3165 ATP synthase delta chain, ev=3e-68, 76% identity YP_614084.1 KEGG: sil:SPO3167 hypothetical protein, ev=1e-111, 75% identity YP_614085.1 PFAM: beta-lactamase-like: (1.6e-33); KEGG: sil:SPO3168 hydroxyacylglutathione hydrolase, , ev=1e-76, 55% identity YP_614086.1 KEGG: sil:SPO3169 ATP-dependent Clp protease, ATP-binding subunit ClpA, ev=0.0, 90% identity; TIGRFAM: ATP-dependent Clp protease ATP-binding subunit clpA: (0); PFAM: AAA ATPase, central region: (7.6e-09) Clp, N terminal: (7.3e-14) ATPase associated with various cellular activities, AAA_5: (1.4e-07) ATPase AAA-2: (1.5e-91); SMART: ATPase: (4.6e-12) YP_614087.1 KEGG: sil:SPO0694 hypothetical protein, ev=6e-16, 30% identity YP_614088.1 KEGG: rsp:RSP_0427 hypothetical protein, ev=7e-12, 41% identity YP_614089.1 PFAM: OmpA/MotB: (2.9e-19); KEGG: sil:SPO3171 OmpA domain protein, ev=0.0, 67% identity YP_614090.1 KEGG: sil:SPO3172 hypothetical protein, ev=1e-154, 72% identity YP_614091.1 PFAM: ChaC-like protein: (1.1e-58); KEGG: sil:SPO3173 cation transport protein ChaC, , ev=3e-69, 72% identity YP_614092.1 KEGG: sil:SPO3174 hypothetical protein, ev=2e-99, 52% identity YP_614093.1 PFAM: Extensin-like-like: (9.2e-43); KEGG: sil:SPO3175 hypothetical protein, ev=6e-74, 52% identity YP_614094.1 dual function enzyme catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate YP_614095.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_614097.1 PFAM: aminotransferase, class V: (2.3e-18); KEGG: sil:SPO3178 hypothetical protein, ev=0.0, 70% identity YP_614098.1 PFAM: regulatory proteins, AsnC/Lrp: (1.3e-24); KEGG: sil:SPO3179 transcriptional regulator, AsnC family, ev=3e-64, 80% identity YP_614099.1 PFAM: GCN5-related N-acetyltransferase: (5.2e-07); KEGG: sil:SPO2447 acetyltransferase, GNAT family, ev=4e-31, 48% identity YP_614100.1 KEGG: sil:SPO3611 hypothetical protein, ev=2e-50, 52% identity YP_614101.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_614102.1 KEGG: sil:SPO3182 hypothetical protein, ev=1e-144, 69% identity YP_614103.1 KEGG: jan:Jann_0952 hypothetical protein, ev=4e-50, 43% identity YP_614104.1 SMART: Rhodanese-like: (3.1e-14); KEGG: jan:Jann_2299 rhodanese-like, ev=1e-41, 64% identity YP_614105.1 PFAM: FAD dependent oxidoreductase: (3.4e-86); KEGG: ppu:PP5257 oxidoreductase, FAD-binding, ev=1e-98, 45% identity YP_614106.1 SMART: regulatory proteins, IclR: (7.6e-09); KEGG: pfo:Pfl_1294 transcriptional regulator, IclR family, ev=1e-19, 27% identity YP_614107.1 PFAM: sulfatase: (3.1e-28); KEGG: sil:SPO3593 sulfatase family protein, ev=0.0, 65% identity YP_614108.1 PFAM: protein of unknown function DUF404: (4.5e-180) protein of unknown function DUF407: (1.3e-84); KEGG: jan:Jann_2676 protein of unknown function DUF404, ev=0.0, 76% identity YP_614109.1 PFAM: protein of unknown function DUF403: (5.9e-110); KEGG: jan:Jann_2677 protein of unknown function DUF403, ev=2e-91, 58% identity YP_614110.1 PFAM: transglutaminase-like: (1.1e-15) transglutaminase-like-like: (8.1e-26); KEGG: jan:Jann_2678 transglutaminase-like, ev=7e-77, 55% identity YP_614111.1 PFAM: 20S proteasome, A and B subunits: (0.0046); KEGG: mlo:mll0713 proteasome-type protease, ev=4e-85, 64% identity YP_614112.1 KEGG: sil:SPO1408 ribosomal large subunit pseudouridine synthase D, ev=1e-146, 74% identity; TIGRFAM: Pseudouridine synthase, RluD: (6.2e-111); PFAM: RNA-binding S4: (8e-05) pseudouridine synthase: (5.9e-68) YP_614113.1 KEGG: sil:SPO1407 hypothetical protein, ev=1e-23, 56% identity YP_614114.1 KEGG: jan:Jann_3405 hypothetical protein, ev=3e-17, 68% identity YP_614115.1 KEGG: lma:LmjF35.0290 hypothetical protein, conserved, ev=2e-09, 29% identity YP_614116.1 PFAM: protein of unknown function DUF1052: (9.5e-44); KEGG: sil:SPO1766 hypothetical protein, ev=9e-61, 78% identity YP_614117.1 KEGG: sil:SPO1765 hypothetical protein, ev=4e-20, 48% identity YP_614118.1 PFAM: adenylyl cyclase class-3/4/guanylyl cyclase: (8.9e-27); KEGG: bja:bll7624 probable adenylate cyclase, ev=1e-145, 57% identity YP_614119.1 TIGRFAM: choline/carnitine/betaine transport: (1.3e-180); PFAM: BCCT transporter: (8.8e-196); KEGG: vpa:VP1723 transporter, BCCT family, ev=0.0, 66% identity YP_614120.1 KEGG: rpb:RPB_3824 UspA, ev=2e-10, 30% identity YP_614121.1 TIGRFAM: transcription antitermination factor NusB: (4.4e-28); PFAM: NusB/RsmB/TIM44: (2.2e-22); KEGG: sil:SPO1763 transcription antitermination factor NusB, ev=2e-64, 76% identity YP_614122.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_614123.1 PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase: (1.8e-106) GTP cyclohydrolase II: (9.5e-08); KEGG: sil:SPO1761 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II, , ev=0.0, 87% identity YP_614124.1 KEGG: sil:SPO1760 hypothetical protein, ev=2e-56, 57% identity YP_614125.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_614126.1 PFAM: Capsule polysaccharide biosynthesis: (3.1e-30); KEGG: sil:SPO1757 capsular polysaccharide export protein KpsS, ev=0.0, 75% identity YP_614127.1 PFAM: polysaccharide export protein: (3.9e-14); KEGG: sil:SPO1756 polysaccharide biosynthesis/export protein, ev=1e-165, 76% identity YP_614128.1 PFAM: Capsule polysaccharide biosynthesis: (2.5e-72); KEGG: sil:SPO1755 capsular polysaccharide export protein KpsC, ev=0.0, 66% identity YP_614129.1 KEGG: sil:SPO1754 riboflavin biosynthesis protein RibD, ev=1e-155, 75% identity; TIGRFAM: riboflavin biosynthesis protein RibD: (1e-118) Riboflavin-specific deaminase-like: (6.1e-54); PFAM: CMP/dCMP deaminase, zinc-binding: (4.5e-27) bifunctional deaminase-reductase-like: (8.7e-51) YP_614130.1 TIGRFAM: Ribonucleotide reductase regulator NrdR-like: (5.4e-49); PFAM: ATP-cone: (2.1e-29); KEGG: sil:SPO1753 riboflavin biosynthesis protein RibX, ev=2e-83, 97% identity YP_614131.1 PFAM: protein of unknown function UPF0047: (3.9e-36); KEGG: atc:AGR_C_3925 It is a member of an uncharacterized protein family PF|01894. ESTs gb|T43915, gb|AA395185 and gb|AI997079 come from this gene., ev=2e-49, 60% identity YP_614132.1 KEGG: sil:SPO1751 hypothetical protein, ev=1e-18, 44% identity YP_614135.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_614136.1 synthesizes RNA primers at the replication forks YP_614137.1 KEGG: sil:SPO1748 hypothetical protein, ev=4e-15, 40% identity YP_614138.1 PFAM: Sarcosine oxidase, gamma subunit: (2.2e-12); KEGG: sil:SPO1747 sarcosine oxidase, gamma subunit family, ev=9e-46, 54% identity YP_614139.1 TIGRFAM: sarcosine oxidase, alpha subunit family: (0); PFAM: glycine cleavage T protein (aminomethyl transferase): (1.3e-41); KEGG: sil:SPO1746 sarcosine oxidase, alpha subunit family, ev=0.0, 70% identity YP_614140.1 PFAM: Sarcosine oxidase, delta subunit, heterotetrameric: (1.3e-33); KEGG: sil:SPO1745 sarcosine oxidase, delta subunit family, ev=2e-24, 62% identity YP_614141.1 TIGRFAM: sarcosine oxidase, beta subunit family: (1.9e-270); PFAM: FAD dependent oxidoreductase: (5.7e-89); KEGG: sil:SPO1744 sarcosine oxidase, beta subunit family, ev=0.0, 76% identity YP_614142.1 PFAM: regulatory protein, TetR: (4.9e-12); KEGG: bat:BAS2304 transcriptional regulator, TetR family, ev=1e-10, 29% identity YP_614143.1 PFAM: Abortive infection protein: (1.4e-08); KEGG: hma:rrnB0071 hypothetical protein, ev=2e-15, 29% identity YP_614144.1 PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal: (1e-73) Glu/Leu/Phe/Val dehydrogenase, dimerisation region: (6.2e-52); KEGG: sil:SPO1743 glutamate dehydrogenase, ev=0.0, 84% identity YP_614145.1 KEGG: sil:SPO1742 hypothetical protein, ev=1e-125, 44% identity YP_614146.1 PFAM: TadE-like: (1.9e-07); KEGG: sil:SPO1741 hypothetical protein, ev=9e-40, 48% identity YP_614147.1 KEGG: sil:SPO1740 hypothetical protein, ev=7e-34, 41% identity YP_614148.1 KEGG: ret:RHE_CH01338 hypothetical protein, ev=3e-24, 43% identity YP_614149.1 PFAM: multi antimicrobial extrusion protein MatE: (1.4e-18); KEGG: rru:Rru_A0678 multi antimicrobial extrusion protein MatE, ev=2e-89, 41% identity YP_614150.1 TIGRFAM: GGDEF domain: (1e-30); PFAM: GGDEF: (3.7e-39) EAL: (1.2e-69) Rh-like protein/ammonium transporter: (4.9e-99); KEGG: tcx:Tcr_2151 ammonium transporter, ev=1e-103, 35% identity YP_614151.1 KEGG: sil:SPO1739 hypothetical protein, ev=2e-48, 60% identity YP_614152.1 PFAM: helix-turn-helix motif: (4.1e-14) Cupin 2, conserved barrel: (4.7e-12); KEGG: ppr:PBPRB1321 transcriptional regulator, HTH_3family, ev=7e-34, 40% identity YP_614153.1 PFAM: Na+/H+ antiporter NhaC: (2.3e-75); KEGG: rsp:RSP_0133 Na+/H+ antiporter, NhaC family, ev=0.0, 70% identity YP_614154.1 PFAM: Pirin-like: (6.2e-45); KEGG: sil:SPO1737 pirin domain protein, ev=1e-154, 84% identity YP_614155.1 PFAM: GCN5-related N-acetyltransferase: (8e-07); KEGG: vfi:VF1328 ferrichrome-binding protein, ev=2e-09, 33% identity YP_614156.1 PFAM: regulatory protein, TetR: (7.5e-12); KEGG: sil:SPO1736 transcriptional regulator, TetR family, ev=1e-70, 72% identity YP_614157.1 KEGG: sil:SPO1735 hypothetical protein, ev=1e-09, 45% identity YP_614158.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_614159.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_614160.1 TIGRFAM: single-stranded-DNA-specific exonuclease RecJ: (1.3e-187); PFAM: phosphoesterase, RecJ-like: (1.6e-37) phosphoesterase, DHHA1: (6.2e-09); KEGG: sil:SPO1732 single-stranded-DNA-specific exonuclease RecJ, ev=0.0, 78% identity YP_614161.1 PFAM: regulatory protein GntR, HTH: (9.8e-13) aminotransferase, class I and II: (5e-08); KEGG: sil:SPO3185 transcriptional regulator, GntR family, ev=1e-139, 55% identity YP_614162.1 PFAM: molybdopterin oxidoreductase: (5e-27) molydopterin dinucleotide-binding region: (6.5e-29) molybdopterin oxidoreductase Fe4S4 region: (8.3e-10); KEGG: sil:SPO3183 oxidoreductase, molybdopterin-binding, ev=0.0, 67% identity YP_614163.1 TIGRFAM: GGDEF domain: (5.1e-30); PFAM: GGDEF: (1.7e-46); KEGG: sil:SPO2747 diguanylate cyclase, , ev=1e-112, 65% identity YP_614164.1 KEGG: sil:SPO2748 hypothetical protein, ev=3e-67, 65% identity YP_614165.1 PFAM: trimethylamine methyltransferase: (1.9e-247); KEGG: sil:SPO2750 trimethylamine methyltransferase family protein, ev=0.0, 82% identity YP_614166.1 TIGRFAM: HAD-superfamily hydrolase subfamily IA, variant 3: (5.6e-06) HAD-superfamily hydrolase, subfamily IA, variant 1: (1.4e-05); PFAM: Haloacid dehalogenase-like hydrolase: (8.3e-28); KEGG: rsp:RSP_0412 phosphatase, ev=5e-59, 52% identity YP_614167.1 KEGG: sil:SPO2752 hypothetical protein, ev=6e-27, 59% identity YP_614168.1 TIGRFAM: GGDEF domain: (1.1e-44); PFAM: GGDEF: (3.4e-58) response regulator receiver: (6.8e-11); KEGG: sil:SPO2753 diguanylate cyclase, /response regulator, ev=1e-115, 50% identity YP_614169.1 KEGG: rsp:RSP_0414 hypothetical protein, ev=5e-10, 30% identity YP_614170.1 KEGG: sil:SPO2755 hypothetical protein, ev=3e-11, 33% identity YP_614171.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_614172.1 KEGG: jan:Jann_3135 calcium-binding EF-hand, ev=6e-20, 44% identity YP_614173.1 PFAM: protein of unknown function DUF983: (5.5e-31); KEGG: sil:SPO2758 hypothetical protein, ev=5e-50, 68% identity YP_614174.1 PFAM: NUDIX hydrolase: (1.3e-11); KEGG: sil:SPO2759 hydrolase, NUDIX family, ev=1e-82, 66% identity YP_614175.1 PFAM: protein of unknown function DUF6, transmembrane: (0.0017); KEGG: sil:SPO1442 membrane protein, , ev=1e-100, 67% identity YP_614176.1 PFAM: fatty acid desaturase: (5.2e-08); KEGG: sil:SPO1441 fatty acid desaturase family protein, ev=2e-99, 58% identity YP_614177.1 KEGG: sil:SPO1440 hypothetical protein, ev=2e-21, 68% identity YP_614178.1 PFAM: helix-turn-helix motif: (9.7e-12); KEGG: sil:SPO1439 DNA binding protein, , ev=1e-121, 75% identity YP_614179.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_614180.1 Converts (S)-3-hydroxyacyl-CoA to 3-oxyacyl-CoA; may also act as a thioesterase YP_614181.1 PFAM: Lipocalin-like: (4.6e-66); KEGG: rsp:RSP_0595 outer membrane lipoprotein Blc, ev=1e-26, 45% identity YP_614182.1 PFAM: protein of unknown function DUF849: (7.1e-195); KEGG: sil:SPO1435 hypothetical protein, ev=1e-151, 86% identity YP_614183.1 PFAM: helix-turn-helix, AraC type: (5.6e-07) ThiJ/PfpI: (2.2e-05); KEGG: sil:SPO1434 transcriptional regulator, AraC family, ev=1e-138, 76% identity YP_614184.1 PFAM: aldo/keto reductase: (1.1e-18); KEGG: sil:SPO1433 oxidoreductase, aldo/keto reductase family, ev=1e-139, 70% identity YP_614185.1 PFAM: major facilitator superfamily MFS_1: (3.8e-24); KEGG: sil:SPO1404 membrane protein, , ev=1e-180, 75% identity YP_614186.1 PFAM: regulatory protein, LysR: (3e-16) LysR, substrate-binding: (1e-25); KEGG: mlo:mlr1832 probable transcriptional regulator, ev=7e-75, 51% identity YP_614187.1 PFAM: short-chain dehydrogenase/reductase SDR: (1.8e-07); KEGG: sme:SMc00136 oxidoreductase protein, ev=1e-95, 69% identity YP_614189.1 PFAM: band 7 protein: (1.4e-14); KEGG: jan:Jann_1794 band 7 protein, ev=0.0, 76% identity YP_614190.1 PFAM: protein of unknown function DUF1449: (6.7e-09); KEGG: jan:Jann_1795 hypothetical protein, ev=4e-56, 49% identity YP_614191.2 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_614192.1 KEGG: rsp:RSP_6006 hypothetical protein, ev=4e-08, 76% identity YP_614193.1 KEGG: sil:SPO0086 lipoprotein, , ev=1e-172, 71% identity YP_614194.1 KEGG: rsp:RSP_1547 probable bacterioferritin-associated ferredoxin, ev=6e-25, 65% identity YP_614195.1 PFAM: Ferritin and Dps: (2.4e-18); KEGG: bmb:BruAb2_0659 Bfr, bacterioferritin, ev=2e-42, 70% identity YP_614196.1 PFAM: protein of unknown function DUF1111: (2.8e-258); KEGG: jan:Jann_1369 protein of unknown function DUF1111, ev=0.0, 64% identity YP_614197.1 KEGG: jan:Jann_1370 hypothetical protein, ev=6e-88, 50% identity YP_614198.1 PFAM: Uncharacterised conserved protein UCP028101: (9e-104); KEGG: sil:SPO0090 hypothetical protein, ev=1e-110, 53% identity YP_614199.1 PFAM: regulatory protein, DeoR: (1.3e-52) Helix-turn-helix, type 11: (5.4e-08); KEGG: sil:SPO0731 glycerol-3-phosphate regulon repressor, ev=7e-92, 69% identity YP_614200.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_614201.1 KEGG: bja:bll3260 cob(I)yrinic acid a,c-diamide adenosyltransferase, ev=1e-89, 79% identity; TIGRFAM: cob(I)alamin adenosyltransferase: (4.2e-82); PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP: (3.2e-81) YP_614202.1 PFAM: protein of unknown function DUF1636: (4.7e-41); KEGG: rsp:RSP_2829 hypothetical protein, ev=1e-27, 59% identity YP_614203.1 TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobW: (1.8e-229); PFAM: cobalamin synthesis protein, P47K: (1.5e-86) cobalamin synthesis CobW-like: (7.2e-19); KEGG: jan:Jann_2933 cobalamin (vitamin B12) biosynthesis CobW, ev=1e-146, 75% identity YP_614204.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism YP_614205.1 TIGRFAM: Precorrin-3B synthase: (8.7e-77); PFAM: nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like: (2.4e-10); KEGG: bja:blr3264 hypothetical protein, ev=1e-87, 48% identity YP_614206.1 catalyzes the interconversion of precorrin-8X and hydrogenobyrinate YP_614207.1 TIGRFAM: precorrin-2 C20-methyltransferase: (2.8e-92); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase: (2.8e-25); KEGG: rsp:RSP_2826 precorrin-2 C20-methyltransferase, ev=9e-94, 68% identity YP_614208.1 TIGRFAM: precorrin-3B C17-methyltransferase: (2.8e-115); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase: (4.2e-24); KEGG: rsp:RSP_2824 precorrin-3B C17-methyltransferase, ev=2e-94, 73% identity YP_614209.1 KEGG: sil:SPO2868 precorrin-6x reductase, ev=1e-76, 56% identity; TIGRFAM: precorrin-6x reductase: (1.3e-35); PFAM: Precorrin-6x reductase CbiJ/CobK: (2.1e-35) YP_614210.1 KEGG: bja:blr3269 precorrin-6Y C5,15-methyltransferase / precorrin-8W decarboxylase, ev=1e-125, 59% identity; TIGRFAM: Precorrin-6y C5,15-methyltransferase, subunit CbiE: (1.6e-27); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase: (4.2e-10) YP_614211.1 KEGG: rsp:RSP_2822 precorrin methylase, ev=1e-16, 45% identity YP_614212.1 TIGRFAM: precorrin-4 C11-methyltransferase: (1.3e-136); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase: (7.9e-58); KEGG: sil:SPO2871 precorrin-4 C11-methyltransferase, ev=1e-114, 75% identity YP_614213.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_614214.1 catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1 YP_614215.1 PFAM: protein of unknown function DUF1636: (3.8e-11); KEGG: mlo:mlr8225 hypothetical protein, ev=7e-12, 37% identity YP_614216.1 TIGRFAM: Cobalt transporter subunit CbtA, : (5.3e-104); KEGG: sil:SPO2876 membrane protein, , ev=2e-97, 74% identity YP_614217.1 KEGG: sil:SPO2877 hypothetical protein, ev=2e-56, 64% identity YP_614218.1 catalyzes the formation of precorrin 6x from precorrin 5 YP_614219.1 TIGRFAM: kynureninase: (3.7e-85); PFAM: aminotransferase, class V: (6.1e-08); KEGG: jan:Jann_2085 kynureninase, ev=1e-154, 66% identity YP_614220.1 PFAM: tryptophan 2,3-dioxygenase: (7e-101); KEGG: jan:Jann_2084 tryptophan 2,3-dioxygenase, ev=1e-104, 68% identity YP_614221.1 PFAM: CheB methylesterase: (2.7e-16) MCP methyltransferase, CheR-type: (6.4e-66); SMART: PAS: (9.7e-06); KEGG: jan:Jann_2564 MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor, ev=0.0, 53% identity YP_614222.1 KEGG: jan:Jann_2565 hypothetical protein, ev=8e-06, 22% identity YP_614223.1 TIGRFAM: GGDEF domain: (1.4e-36); PFAM: GGDEF: (4.5e-47) EAL: (5.6e-58); KEGG: jan:Jann_2600 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s), ev=7e-96, 36% identity YP_614224.1 PFAM: Alcohol dehydrogenase, zinc-binding: (1.6e-30) Alcohol dehydrogenase GroES-like: (2.4e-12); KEGG: sil:SPO0616 oxidoreductase, zinc-binding dehydrogenase family, ev=1e-70, 44% identity YP_614225.1 PFAM: Endoribonuclease L-PSP: (7.7e-24); KEGG: sil:SPOA0400 endoribonuclease L-PSP family protein, ev=1e-48, 66% identity YP_614226.1 PFAM: thioesterase superfamily: (3.1e-10); KEGG: sil:SPO0786 thioesterase family protein, ev=2e-38, 60% identity YP_614227.1 PFAM: ABC transporter related: (2.2e-47); SMART: ATPase: (2.3e-12); KEGG: bja:blr1067 ABC transporter ATP-binding protein, ev=1e-62, 52% identity YP_614228.1 PFAM: ABC transporter related: (1.4e-39); SMART: ATPase: (2e-10); KEGG: bja:blr1066 ABC transporter ATP-binding protein, ev=1e-59, 49% identity YP_614229.1 PFAM: inner-membrane translocator: (2e-33); KEGG: bja:blr1065 ABC transporter permease protein, ev=1e-75, 49% identity YP_614230.1 PFAM: inner-membrane translocator: (3.3e-32); KEGG: bja:blr1064 ABC transporter permease protein, ev=1e-89, 57% identity YP_614231.1 KEGG: dar:Daro_4043 extracellular ligand-binding receptor, ev=1e-104, 50% identity YP_614232.1 PFAM: AMP-dependent synthetase and ligase: (2.2e-101); KEGG: sil:SPOA0401 benzoate-coenzyme A ligase, ev=0.0, 81% identity YP_614233.1 PFAM: acyl-CoA dehydrogenase-like: (2.8e-50) Acyl-CoA dehydrogenase, type 2-like: (1.6e-22); KEGG: sil:SPOA0403 acyl-CoA dehydrogenase family protein, ev=1e-166, 79% identity YP_614234.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_614235.1 PFAM: regulatory protein, MarR: (1.2e-10); KEGG: jan:Jann_1325 transcriptional regulator, MarR family, ev=1e-40, 60% identity YP_614236.1 PFAM: short-chain dehydrogenase/reductase SDR: (4.8e-30); KEGG: jan:Jann_1324 short-chain dehydrogenase/reductase SDR, ev=2e-82, 65% identity YP_614237.1 catalyzes the conversion of salicylyl-CoA to gentisyl-CoA YP_614238.1 PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding: (1.1e-09); KEGG: hch:HCH_03324 predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase, ev=1e-72, 46% identity YP_614239.1 PFAM: glutathione S-transferase-like: (6.6e-18); KEGG: hch:HCH_03323 glutathione S-transferase, ev=3e-64, 53% identity YP_614240.1 PFAM: protein of unknown function DUF1348: (4e-93); KEGG: nar:Saro_2764 protein of unknown function DUF1348, ev=6e-71, 80% identity YP_614241.1 PFAM: regulatory protein, LysR: (5.7e-19) LysR, substrate-binding: (2.9e-40); KEGG: cvi:CV1773 GstR-like transcriptional regulator protein, ev=1e-81, 51% identity YP_614242.1 KEGG: sil:SPO3245 nicotinate-nucleotide pyrophosphorylase, ev=1e-110, 75% identity; TIGRFAM: nicotinate-nucleotide pyrophosphorylase: (3.2e-126); PFAM: Quinolinate phosphoribosyl transferase: (4.9e-84) YP_614243.1 catalyzes the formation of oxaloacetate from L-aspartate YP_614244.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_614245.1 KEGG: rsp:RSP_0200 ABC transporter, periplasmic binding protein, ev=1e-121, 56% identity YP_614246.1 KEGG: rsp:RSP_0201 ABC transporter, fused inner membrane subunits, ev=1e-169, 57% identity YP_614247.1 PFAM: ABC transporter related: (2.4e-48); SMART: ATPase: (1.1e-13); KEGG: rsp:RSP_6101 ABC transporter, ATPase subunit, ev=2e-64, 60% identity YP_614249.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_614252.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_614253.1 TIGRFAM: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase: (1.8e-25) Twin-arginine translocation pathway signal: (0.016); PFAM: peptidase S13, D-Ala-D-Ala carboxypeptidase C: (2.4e-24); KEGG: sil:SPO0451 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase, ev=1e-150, 54% identity YP_614254.1 KEGG: sil:SPO0452 hypothetical protein, ev=3e-57, 79% identity YP_614255.1 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine YP_614256.1 KEGG: sil:SPO0457 hypothetical protein, ev=1e-34, 57% identity YP_614257.1 KEGG: sil:SPO0459 hypothetical protein, ev=0.0, 64% identity YP_614258.1 PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding: (1.2e-12); KEGG: jan:Jann_3613 pyridoxamine 5'-phosphate oxidase-related, FMN-binding, ev=7e-38, 53% identity YP_614259.1 KEGG: sil:SPO0460 hypothetical protein, ev=4e-17, 29% identity YP_614260.1 PFAM: Antibiotic biosynthesis monooxygenase: (8.5e-05); KEGG: sil:SPO0462 antibiotic biosynthesis monooxygenase domain protein, ev=7e-41, 74% identity YP_614261.1 KEGG: rsp:RSP_0683 hypothetical protein, ev=3e-14, 39% identity YP_614262.1 PFAM: metal-dependent protein hydrolase: (1.5e-26); KEGG: atc:AGR_L_2056 MYG1 protein, ev=1e-110, 65% identity YP_614263.1 PFAM: lipolytic enzyme, G-D-S-L: (2.4e-20); KEGG: sil:SPO0435 acyl-CoA thioesterase, , ev=3e-57, 61% identity YP_614264.1 PFAM: ABC transporter related: (4.5e-64); SMART: ATPase: (3.4e-16); KEGG: rsp:RSP_3602 ABC efflux transporter, ATPase subunit, ev=9e-90, 75% identity YP_614265.1 PFAM: protein of unknown function DUF214: (9.5e-14); KEGG: sil:SPO0433 ABC transporter, permease protein, ev=0.0, 69% identity YP_614266.1 PFAM: protein of unknown function UPF0074: (5.9e-45); KEGG: sil:SPO0432 rrf2 family protein, ev=2e-55, 72% identity YP_614267.1 KEGG: sil:SPO0431 hypothetical protein, ev=5e-45, 48% identity YP_614268.1 KEGG: jan:Jann_2342 hypothetical protein, ev=9e-64, 38% identity YP_614269.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_614270.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.027); PFAM: beta-lactamase-like: (5.1e-14); KEGG: sil:SPO0429 metallo-beta-lactamase family protein, ev=1e-113, 66% identity YP_614271.1 PFAM: FAD dependent oxidoreductase: (3.1e-94) FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (0.0014); KEGG: sil:SPO0428 amino acid deaminase, , ev=1e-144, 56% identity YP_614272.1 NH(3)-dependent; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_614273.1 PFAM: MORN motif: (0.00013); KEGG: sil:SPO0425 MORN repeat protein, ev=0.0, 71% identity YP_614275.1 PFAM: deoxyribodipyrimidine photolyase-related protein: (3.6e-63); KEGG: rsp:RSP_3077 hypothetical protein, ev=0.0, 68% identity YP_614276.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_614277.1 KEGG: atc:AGR_C_231 transport protein, ev=2e-95, 46% identity YP_614278.1 TIGRFAM: ubiquinol oxidase, subunit II: (5.3e-133); PFAM: COX aromatic rich: (6.2e-13); KEGG: rpb:RPB_0242 ubiquinol oxidase, subunit II, ev=1e-104, 57% identity YP_614279.1 PFAM: cytochrome c oxidase, subunit I: (3e-242); KEGG: atc:AGR_C_227 ba-type ubiquinol oxidase chain I, ev=0.0, 69% identity YP_614280.1 PFAM: cytochrome c oxidase, subunit III: (0.0015); KEGG: atc:AGR_C_225 bo-type ubiquinol oxidase chain III, ev=4e-70, 60% identity YP_614281.1 PFAM: cytochrome C oxidase subunit IV: (4.3e-35); KEGG: rpb:RPB_0239 cytochrome c oxidase subunit IV, ev=1e-30, 56% identity YP_614282.1 PFAM: Surfeit locus 1: (1e-06); KEGG: bja:blr0153 probable surfeit locus protein 1, ev=1e-41, 39% identity YP_614283.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (5.8e-15); KEGG: rsp:RSP_3237 lactoylglutathione lyase, ev=3e-42, 62% identity YP_614284.1 PFAM: histidine triad (HIT) protein: (3.8e-42); KEGG: sil:SPO1386 HIT family protein, ev=2e-58, 83% identity YP_614285.1 PFAM: cytochrome c oxidase, subunit I: (8e-288); KEGG: sil:SPO1383 cytochrome c oxidase, aa3-type, subunit I, ev=0.0, 90% identity YP_614286.1 KEGG: sil:SPO1381 hypothetical protein, ev=2e-45, 55% identity YP_614287.1 PFAM: GatB/Yqey: (6.9e-37); KEGG: sil:SPO1378 GatB/YqeY domain protein, ev=3e-63, 77% identity YP_614288.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_614289.1 PFAM: glycosyl transferase, family 2: (1.6e-06); KEGG: sil:SPO1376 glycosyl transferase, group 2 family protein, ev=1e-142, 52% identity YP_614290.1 PFAM: regulatory protein GntR, HTH: (4e-17) GntR-like: (5.5e-30); KEGG: sil:SPO1375 transcriptional regulator, GntR family, ev=7e-88, 81% identity YP_614291.1 TIGRFAM: HAD-superfamily hydrolase subfamily IA, variant 3: (2.4e-07) Pyrimidine 5-nucleotidase: (3.4e-74); PFAM: Haloacid dehalogenase-like hydrolase: (3.3e-12); KEGG: sil:SPO1374 pyrimidine 5'-nucleotidase, ev=3e-91, 72% identity YP_614292.1 KEGG: sil:SPO1372 hypothetical protein, ev=3e-26, 68% identity YP_614293.1 TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family: (4.9e-85); PFAM: monooxygenase, FAD-binding: (5.8e-10) FAD dependent oxidoreductase: (0.0017); KEGG: sil:SPO1371 2-octaprenyl-6-methoxyphenol hydroxylase, , ev=1e-166, 74% identity YP_614294.1 PFAM: aminotransferase, class V: (0.00029); KEGG: sil:SPO1370 aminotransferase family protein, ev=1e-169, 79% identity YP_614295.1 PFAM: regulatory proteins, AsnC/Lrp: (9.1e-24) regulatory protein, ArsR: (0.0044); KEGG: sil:SPO1368 transcriptional regulator, AsnC family, ev=1e-62, 79% identity YP_614296.1 PFAM: regulatory proteins, AsnC/Lrp: (7.6e-14); KEGG: sil:SPO1367 transcriptional regulator, AsnC family, ev=6e-52, 67% identity YP_614297.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_614298.1 PFAM: protein of unknown function DUF6, transmembrane: (2e-14) Protein of unknown function DUF250: (0.0036); KEGG: sil:SPO1365 membrane protein, , ev=6e-98, 61% identity YP_614299.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_614300.1 KEGG: sil:SPO1363 dihydropteroate synthase, ev=1e-104, 73% identity; TIGRFAM: dihydropteroate synthase: (1.3e-138); PFAM: dihydropteroate synthase, DHPS: (2.7e-100) YP_614301.1 TIGRFAM: Dihydroneopterin aldolase: (5.4e-07); KEGG: sil:SPO1362 dihydroneopterin aldolase, , ev=1e-130, 78% identity YP_614302.1 PFAM: cell wall hydrolase, SleB: (7.4e-36); KEGG: sil:SPO1360 hypothetical protein, ev=1e-62, 59% identity YP_614303.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_614304.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_614305.1 KEGG: rsp:RSP_1857 hypothetical protein, ev=2e-36, 48% identity YP_614306.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_614307.1 PFAM: Peptidoglycan-binding domain 1: (3.8e-11) Sporulation related: (4.6e-05); KEGG: sil:SPO1354 peptidoglycan binding domain protein, ev=0.0, 61% identity YP_614308.1 TIGRFAM: sugar-phosphate isomerases, RpiB/LacA/LacB family: (5.1e-65) ribose 5-phosphate isomerase B: (1.7e-56); PFAM: Ribose/galactose isomerase: (6e-46); KEGG: sil:SPO3180 ribose 5-phosphate isomerase B, ev=1e-61, 78% identity YP_614309.1 PFAM: short-chain dehydrogenase/reductase SDR: (7.2e-07); KEGG: sil:SPO3051 oxidoreductase, short-chain dehydrogenase/reductase family, ev=5e-81, 70% identity YP_614310.1 PFAM: protein of unknown function DUF1178: (1.7e-53); KEGG: rsp:RSP_2387 hypothetical protein, ev=8e-45, 53% identity YP_614311.1 KEGG: sil:SPO3054 hypothetical protein, ev=4e-74, 60% identity YP_614312.1 PFAM: GCN5-related N-acetyltransferase: (7.4e-08); KEGG: sil:SPO3055 acetyltransferase, GNAT family, ev=9e-67, 75% identity YP_614313.1 KEGG: sil:SPO3056 hypothetical protein, ev=2e-89, 74% identity YP_614314.1 PFAM: transferase hexapeptide repeat: (0.031); KEGG: sil:SPO3057 streptogramin acetyltransferase, , ev=4e-87, 68% identity YP_614315.1 PFAM: Sulfate transporter/antisigma-factor antagonist STAS: (0.00075) Xanthine/uracil/vitamin C permease: (8.4e-05) sulphate transporter: (1.3e-68); KEGG: sil:SPO3058 sulfate transporter family protein, ev=0.0, 80% identity YP_614317.1 KEGG: sma:SAV6152 hypothetical protein, ev=4e-13, 25% identity YP_614318.1 Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate YP_614319.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_614320.1 PFAM: beta-Ig-H3/fasciclin: (1.1e-55); KEGG: rsp:RSP_1409 beta-Ig-H3/fasciclin, ev=3e-45, 60% identity YP_614321.1 PFAM: FAD linked oxidase-like: (1.1e-52); KEGG: sil:SPO3067 oxidoreductase, FAD-binding, ev=0.0, 70% identity YP_614322.1 PFAM: GCN5-related N-acetyltransferase: (8.2e-11); KEGG: sil:SPO3069 ribosomal-protein-alanine acetyltransferase, , ev=2e-87, 78% identity YP_614323.1 PFAM: peptidase M16-like: (1.3e-48); KEGG: sil:SPO3070 peptidase, M16 family, ev=0.0, 78% identity YP_614324.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_614325.1 KEGG: sil:SPO3072 SURF1 family protein, ev=3e-65, 57% identity YP_614326.1 PFAM: cytochrome c oxidase, subunit III: (5e-88); KEGG: sil:SPO3073 cytochrome c oxidase, subunit III, ev=1e-129, 77% identity YP_614327.1 involved in the insertion of copper into subunit I of cytochrome C oxidase YP_614328.1 KEGG: rsp:RSP_6021 hypothetical protein, ev=3e-07, 55% identity YP_614329.1 converts protoheme IX and farnesyl diphosphate to heme O YP_614330.1 PFAM: cytochrome c oxidase, subunit II: (2.5e-50) cytochrome C oxidase subunit II, transmembrane region: (8.7e-26); KEGG: sil:SPO3076 cytochrome c oxidase, subunit II, ev=1e-108, 64% identity YP_614331.1 PFAM: peptidase U62, modulator of DNA gyrase: (3.4e-74); KEGG: sil:SPO3077 TldD/PmbA family protein, ev=0.0, 82% identity YP_614332.1 TIGRFAM: DNA processing protein DprA, : (1.9e-73); PFAM: SMF protein: (1.2e-75); KEGG: sil:SPO3078 DNA processing protein DprA, , ev=1e-127, 63% identity YP_614333.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_614334.1 KEGG: sil:SPO3082 3-oxoadipate CoA-succinyl transferase, alpha subunit, ev=1e-113, 85% identity; TIGRFAM: 3-oxoacid CoA-transferase, subunit A: (1.3e-82); PFAM: coenzyme A transferase: (1.5e-95) YP_614335.1 KEGG: sil:SPO3083 3-oxoadipate CoA-succinyl transferase, beta subunit, ev=1e-106, 91% identity; TIGRFAM: 3-oxoacid CoA-transferase, subunit B: (1.1e-146); PFAM: coenzyme A transferase: (9.2e-54) YP_614336.1 PFAM: Lytic transglycosylase, catalytic: (1.4e-24); KEGG: sil:SPO3084 transglycosylase, Slt family, ev=4e-75, 55% identity YP_614337.1 KEGG: sil:SPO3085 hypothetical protein, ev=4e-11, 64% identity YP_614338.1 KEGG: rsp:RSP_6025 hypothetical protein, ev=2e-07, 49% identity YP_614339.1 PFAM: Flp pilus assembly CpaB: (6.2e-29); KEGG: sil:SPO3086 CpaB family protein, ev=1e-103, 66% identity YP_614340.1 PFAM: type II and III secretion system protein: (6.1e-57) transport-associated: (1e-08); KEGG: sil:SPO3087 bacterial type II/III secretion system protein, ev=1e-179, 69% identity YP_614341.1 PFAM: OmpA/MotB: (4.5e-19); KEGG: sil:SPO3088 OmpA family protein, ev=3e-63, 61% identity YP_614342.1 KEGG: sil:SPO3089 ATPase, , ev=1e-174, 72% identity YP_614343.1 PFAM: type II secretion system protein E: (1.7e-119); KEGG: sil:SPO3090 type II/IV secretion system protein, TadA subfamily, ev=0.0, 85% identity YP_614344.1 PFAM: type II secretion system protein: (4.1e-09); KEGG: sil:SPO3091 type II/IV secretion system protein, TadC subfamily, ev=1e-140, 79% identity YP_614345.1 PFAM: type II secretion system protein: (9e-17); KEGG: sil:SPO3092 type II/IV secretion system protein, TadC subfamily, ev=1e-131, 73% identity YP_614346.1 PFAM: TPR repeat: (0.00041) Tetratricopeptide TPR_4: (0.0013) Tetratricopeptide TPR_2: (1.9e-05); SMART: Tetratricopeptide region: (2.7e-06); KEGG: sil:SPO3093 TPR domain protein, ev=2e-47, 51% identity YP_614347.1 SMART: Tetratricopeptide region: (0.15); KEGG: sil:SPO3094 lipoprotein, , ev=1e-111, 70% identity YP_614348.1 KEGG: sil:SPO3095 membrane protein, , ev=3e-39, 47% identity YP_614349.1 KEGG: sil:SPO3096 hypothetical protein, ev=0.0, 86% identity YP_614350.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_614351.1 PFAM: Chorismate mutase: (2e-18); KEGG: sil:SPO3102 chorismate mutase family protein, ev=3e-29, 64% identity YP_614352.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_614353.1 PFAM: MOSC: (2.6e-07); KEGG: sil:SPO3104 MOSC domain protein, ev=4e-66, 62% identity YP_614354.1 KEGG: rsp:RSP_0664 hypothetical protein, ev=1e-17, 35% identity YP_614355.1 KEGG: sil:SPO3105 ATP-dependent metalloprotease FtsH, ev=0.0, 89% identity; TIGRFAM: ATP-dependent metalloprotease FtsH: (0); PFAM: peptidase M41: (3.6e-96) AAA ATPase, central region: (6.3e-98) peptidase M41, FtsH extracellular: (4.1e-41) ATPase associated with various cellular activities, AAA_5: (0.0005); SMART: ATPase: (2.2e-26) YP_614356.1 TIGRFAM: tRNA(Ile)-lysidine synthetase-like: (5.9e-62); PFAM: PP-loop: (2.2e-55); KEGG: sil:SPO3106 PP-loop family protein, ev=1e-87, 45% identity YP_614357.1 PFAM: Tetratricopeptide TPR_2: (0.0047); KEGG: sil:SPO3107 hypothetical protein, ev=2e-74, 56% identity YP_614358.1 PFAM: OmpA/MotB: (1.3e-31); KEGG: jan:Jann_0976 OmpA/MotB, ev=1e-48, 59% identity YP_614359.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_614360.1 KEGG: sil:SPO3110 TonB domain protein, , ev=2e-95, 50% identity YP_614361.1 PFAM: Biopolymer transport protein ExbD/TolR: (4.7e-21); KEGG: sil:SPO3111 biopolymer transport protein, ExbD/TolR family, ev=8e-65, 81% identity YP_614362.1 PFAM: MotA/TolQ/ExbB proton channel: (1.8e-46); KEGG: sil:SPO3112 proton transporter TolQ, ev=1e-107, 83% identity YP_614363.1 TIGRFAM: 4-hydroxybenzoyl-CoA thioesterase: (1.5e-37); PFAM: thioesterase superfamily: (6.7e-17); KEGG: sil:SPO3113 conserved hypothetical protein TIGR00051, ev=2e-44, 69% identity YP_614364.1 KEGG: sil:SPO3114 hypothetical protein, ev=4e-78, 70% identity YP_614365.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_614366.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_614367.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_614368.1 PFAM: protein of unknown function DUF1127: (3.1e-06); KEGG: sil:SPO3118 hypothetical protein, ev=1e-14, 59% identity YP_614369.1 KEGG: sil:SPO3119 hypothetical protein, ev=5e-13, 46% identity YP_614370.1 PFAM: methyltransferase small: (2e-05) ribosomal L11 methyltransferase: (2.3e-47) Methyltransferase type 12: (0.00024); KEGG: sil:SPO3120 ribosomal protein L11 methyltransferase, , ev=1e-130, 81% identity YP_614371.1 PFAM: major facilitator superfamily MFS_1: (3.5e-09); KEGG: sil:SPO3122 membrane protein, , ev=0.0, 79% identity YP_614372.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_614373.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_614374.1 KEGG: sil:SPO3129 hypothetical protein, ev=7e-80, 65% identity YP_614375.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_614376.1 PFAM: CDP-alcohol phosphatidyltransferase: (0.0088); KEGG: sil:SPO3131 phosphatidylcholine synthase, ev=1e-102, 76% identity YP_614378.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_614379.1 PFAM: protein of unknown function DUF463, YcjX-like protein: (3.7e-130); KEGG: sil:SPO3142 hypothetical protein, ev=0.0, 72% identity YP_614380.1 PFAM: GCN5-related N-acetyltransferase: (6.6e-13); KEGG: sil:SPO3141 acetyltransferase, GNAT family, ev=3e-38, 53% identity YP_614381.1 KEGG: sil:SPO3140 conserved hypothetical protein TIGR01620, ev=5e-94, 55% identity YP_614382.1 KEGG: sil:SPO3139 hypothetical protein, ev=2e-41, 60% identity YP_614383.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_614385.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_614386.1 TIGRFAM: glycine cleavage system H protein: (3.1e-42); PFAM: glycine cleavage H-protein: (4.6e-51); KEGG: sil:SPO0878 glycine cleavage system H protein, ev=3e-51, 81% identity YP_614387.1 TIGRFAM: glycine cleavage system T protein: (4.4e-95); PFAM: glycine cleavage T protein (aminomethyl transferase): (1.7e-88); KEGG: rsp:RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent, ev=1e-132, 64% identity YP_614388.1 PFAM: glyceraldehyde 3-phosphate dehydrogenase: (2.6e-68); KEGG: sil:SPO0875 glyceraldehyde-3-phosphate dehydrogenase, type I, ev=1e-123, 67% identity YP_614389.1 PFAM: surface antigen (D15): (4.1e-35); KEGG: sil:SPO0868 outer membrane protein, OMP85 family, ev=1e-170, 51% identity YP_614390.1 PFAM: protein of unknown function DUF490: (3e-39); KEGG: sil:SPO0867 hypothetical protein, ev=0.0, 43% identity YP_614391.1 PFAM: glycosyl transferase, family 2: (1.6e-14); KEGG: jan:Jann_4255 glycosyl transferase, family 2, ev=1e-103, 59% identity YP_614392.1 TIGRFAM: glycosyl transferase, WecB/TagA/CpsF family: (8.8e-28); PFAM: glycosyl transferase WecB/TagA/CpsF: (2.4e-28); KEGG: sil:SPO0851 glycosyl transferase, WecB/TagA/CpsF family, ev=5e-72, 60% identity YP_614393.1 KEGG: sil:SPO0850 membrane protein, , ev=1e-137, 50% identity YP_614394.1 PFAM: beta-ketoacyl synthase: (4.6e-76) Thioesterase: (4.9e-08) acyl transferase region: (4.2e-49) short-chain dehydrogenase/reductase SDR: (3e-38) phosphopantetheine-binding: (6e-21); KEGG: sil:SPO0849 non-ribosomal peptide synthase, ev=0.0, 63% identity YP_614395.1 PFAM: glycosyl transferase, family 2: (5.5e-08); KEGG: sil:SPO0848 glycosyl transferase, group 2 family protein, ev=1e-108, 57% identity YP_614396.1 TIGRFAM: Amino acid adenylation: (2.6e-117); PFAM: AMP-dependent synthetase and ligase: (8.5e-132) formyl transferase-like: (4.7e-09) phosphopantetheine-binding: (9.3e-14) luciferase-like: (2.1e-13); KEGG: sil:SPO0847 non-ribosomal peptide synthetase, ev=0.0, 62% identity YP_614397.1 PFAM: 4'-phosphopantetheinyl transferase: (2.9e-07); KEGG: sil:SPO0846 phosphopantetheinyl transferase PptA, , ev=1e-44, 46% identity YP_614398.1 KEGG: sil:SPO0845 hypothetical protein, ev=6e-76, 50% identity YP_614399.1 KEGG: sil:SPO0844 hypothetical protein, ev=0.0, 53% identity YP_614400.1 PFAM: glycosyl transferase, family 2: (1.4e-19); KEGG: sil:SPO0843 glycosyl transferase, group 2 family protein, ev=5e-75, 53% identity YP_614401.1 PFAM: glycosyl transferase, group 1: (1.1e-37); KEGG: sil:SPO0842 glycosyl transferase, group 1 family protein, ev=1e-134, 64% identity YP_614402.1 PFAM: polysaccharide biosynthesis protein: (4e-16); KEGG: sil:SPO0841 polysaccharide biosynthesis protein, ev=1e-121, 48% identity YP_614403.1 PFAM: lipopolysaccharide biosynthesis: (0.013); KEGG: sil:SPO0840 chain length determinant protein, , ev=1e-104, 49% identity YP_614404.1 KEGG: sil:SPO0839 exopolysaccharide biosynthesis domain protein, ev=2e-63, 44% identity YP_614405.1 PFAM: sugar transferase: (3.1e-66); KEGG: sil:SPO0838 bacterial sugar transferase, ev=2e-63, 58% identity YP_614406.1 PFAM: helix-turn-helix, AraC type: (2.2e-09); KEGG: bur:Bcep18194_B2989 transcriptional regulator, AraC family, ev=1e-26, 28% identity YP_614407.1 KEGG: sil:SPO0785 2-dehydro-3-deoxygalactonokinase, , ev=8e-27, 31% identity YP_614408.1 KEGG: sil:SPO0581 hypothetical protein, ev=6e-64, 50% identity YP_614409.1 PFAM: RNA methylase: (6.3e-33); KEGG: sil:SPOA0322 hypothetical protein, ev=1e-127, 62% identity YP_614410.1 PFAM: extracellular solute-binding protein, family 1: (4.2e-07); KEGG: sil:SPO0608 sugar ABC transporter, periplasmic sugar-binding protein, ev=0.0, 92% identity YP_614411.1 PFAM: ABC transporter related: (4.7e-46) Transport-associated OB: (4.9e-06); SMART: ATPase: (7.4e-11); KEGG: sil:SPO0609 sugar ABC transporter, ATP-binding protein, ev=1e-166, 83% identity YP_614412.1 PFAM: ABC transporter related: (7.4e-41) TOBE: (0.00016) Transport-associated OB: (1.6e-06); SMART: ATPase: (3e-13); KEGG: sil:SPO0610 sugar ABC transporter, ATP-binding protein, ev=1e-166, 82% identity YP_614413.1 PFAM: binding-protein-dependent transport systems inner membrane component: (0.0001); KEGG: sil:SPO0611 sugar ABC transporter, permease protein, ev=1e-161, 96% identity YP_614414.1 PFAM: binding-protein-dependent transport systems inner membrane component: (5.8e-09); KEGG: sil:SPO0612 sugar ABC transporter, permease protein, ev=1e-142, 93% identity YP_614415.1 KEGG: sil:SPO0613 hypothetical protein, ev=2e-45, 89% identity YP_614416.1 PFAM: Penicillinase repressor: (1.4e-28); KEGG: sil:SPO0614 transcriptional regulator, , ev=6e-52, 80% identity YP_614417.1 PFAM: peptidase M56, BlaR1: (5.2e-08); KEGG: sil:SPO0615 hypothetical protein, ev=1e-104, 52% identity YP_614418.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA YP_614419.1 KEGG: sil:SPO0718 hypothetical protein, ev=1e-64, 49% identity YP_614420.1 PFAM: electron transfer flavoprotein beta-subunit: (3e-40) electron transfer flavoprotein, alpha subunit: (4.9e-58); KEGG: sil:SPO0719 electron transfer flavoprotein, alpha subunit, ev=1e-148, 88% identity YP_614421.1 PFAM: electron transfer flavoprotein beta-subunit: (2.5e-77); KEGG: sil:SPO0720 electron transfer flavoprotein, beta subunit, ev=1e-124, 90% identity YP_614422.1 TIGRFAM: ATP: (7.6e-78); PFAM: cobalamin adenosyltransferase: (2.5e-92); KEGG: sil:SPO0722 ATP:cob(I)alamin adenosyltransferase, , ev=1e-79, 77% identity YP_614423.1 KEGG: sil:SPO0723 hypothetical protein, ev=2e-13, 57% identity YP_614424.1 PFAM: short-chain dehydrogenase/reductase SDR: (5.4e-18); KEGG: sil:SPO0724 oxidoreductase, short-chain dehydrogenase/reductase family, ev=1e-124, 78% identity YP_614425.1 PFAM: SH3: (0.13) SH3, type 3: (2.2e-06); SMART: SH3-like region: (2e-10); KEGG: rsp:RSP_1695 hypothetical protein, ev=6e-08, 30% identity YP_614426.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_614427.1 KEGG: sil:SPO0727 hypothetical protein, ev=6e-59, 61% identity YP_614428.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_614429.1 KEGG: sil:SPO0716 hypothetical protein, ev=1e-131, 76% identity YP_614430.1 TIGRFAM: Phosphotransferase system, HPr: (1.3e-28); PFAM: phosphocarrier HPr protein: (2.9e-23); KEGG: sil:SPO0715 phosphocarrier protein HPr, ev=3e-36, 85% identity YP_614431.1 PFAM: PTS system fructose subfamily IIA component: (1e-21); KEGG: sil:SPO0714 PTS system IIA component, Man family, ev=1e-53, 84% identity YP_614432.1 PFAM: Uncharacterised P-loop ATPase protein UPF0042: (6e-80); KEGG: sil:SPO0713 ATPase, , ev=1e-94, 63% identity YP_614433.1 KEGG: rsp:RSP_1683 kinase/phosphatase, ev=3e-33, 56% identity YP_614434.1 PFAM: ATP-binding region, ATPase-like: (5.3e-35) histidine kinase, HAMP region: (7.5e-10) histidine kinase A-like: (2.9e-16); KEGG: sil:SPO0711 sensor histidine kinase ChvG, ev=0.0, 70% identity YP_614435.1 PFAM: response regulator receiver: (8.4e-34) transcriptional regulatory protein-like: (2.5e-18); KEGG: sil:SPO0710 DNA-binding response regulator ChvI, ev=1e-121, 96% identity YP_614436.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_614437.1 PFAM: lipolytic enzyme, G-D-S-L: (1.2e-05); KEGG: sil:SPO3303 GDSL-like lipase/acylhydrolase, , ev=9e-60, 51% identity YP_614438.1 PFAM: acyl-CoA dehydrogenase-like: (1.1e-51) Acyl-CoA dehydrogenase, type 2-like: (1.5e-06); KEGG: sil:SPO0693 isobutyryl-CoA dehydrogenase, ev=0.0, 86% identity YP_614439.1 PFAM: protein of unknown function DUF81: (1.3e-08); KEGG: jan:Jann_0531 protein of unknown function DUF81, ev=1e-50, 39% identity YP_614440.1 TIGRFAM: cation diffusion facilitator family transporter: (8.2e-67); PFAM: cation efflux protein: (5.9e-83); KEGG: ret:RHE_CH03072 probable cation efflux protein, ev=4e-84, 54% identity YP_614441.1 PFAM: NADPH-dependent FMN reductase: (9.3e-25); KEGG: sil:SPO3573 NADPH-dependent FMN reductase domain protein, ev=1e-63, 70% identity YP_614442.1 PFAM: OmpA/MotB: (2e-26); KEGG: sil:SPO3576 OmpA domain protein, ev=2e-67, 60% identity YP_614443.1 PFAM: Helix-turn-helix, type 11: (2.8e-16); KEGG: sil:SPO3577 hypothetical protein, ev=6e-78, 63% identity YP_614444.1 TIGRFAM: methylated-DNA--protein-cysteine methyltransferase: (2.3e-36); PFAM: helix-turn-helix, AraC type: (9.3e-08) methylated-DNA-[protein]-cysteine S-methyltransferase: (2.5e-35); KEGG: sil:SPO3578 ADA regulatory protein, ev=1e-115, 70% identity YP_614445.1 KEGG: sil:SPO3581 endonuclease III, ev=1e-106, 85% identity; TIGRFAM: endonuclease III: (1.3e-104); PFAM: helix-hairpin-helix motif: (8e-07) HhH-GPD: (3.4e-13); SMART: Iron-sulfur cluster loop: (3.9e-06) YP_614446.1 PFAM: PfkB: (7.2e-41); KEGG: sil:SPO3582 kinase, PfkB family, ev=1e-142, 79% identity YP_614447.1 PFAM: histidine kinase, HAMP region: (1.9e-13) chemotaxis sensory transducer: (6.8e-88); KEGG: atc:AGR_L_2218 hypothetical chemoreceptor gene similar to orf2 gene in pTi15955, ev=2e-93, 32% identity YP_614448.1 PFAM: regulatory protein, MarR: (5.6e-17); KEGG: sil:SPO3583 transcriptional regulator PecS, ev=1e-49, 62% identity YP_614449.1 PFAM: protein of unknown function DUF6, transmembrane: (8.4e-22); KEGG: sil:SPO3584 membrane protein, drug/metabolite transporter (DMT) family, ev=1e-105, 65% identity YP_614451.1 PFAM: NUDIX hydrolase: (1.6e-27); KEGG: sil:SPO3585 hydrolase, NUDIX family, NudH subfamily, ev=9e-62, 67% identity YP_614452.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase: (1.6e-113) FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (0.0034); KEGG: sil:SPO3586 2,4-dienoyl-CoA reductase, ev=0.0, 84% identity YP_614453.1 PFAM: 2-nitropropane dioxygenase, NPD: (1.8e-68); KEGG: nar:Saro_1176 2-nitropropane dioxygenase, NPD, ev=2e-96, 56% identity YP_614454.1 PFAM: regulatory protein, LysR: (2.6e-18) LysR, substrate-binding: (2.9e-51); KEGG: sil:SPO3592 transcriptional regulator, LysR family, ev=1e-154, 90% identity YP_614455.1 PFAM: NIPSNAP: (2.3e-29); KEGG: sil:SPO3589 hypothetical protein, ev=7e-44, 78% identity YP_614456.1 PFAM: Antibiotic biosynthesis monooxygenase: (5.8e-14); KEGG: sil:SPO3588 hypothetical protein, ev=1e-39, 71% identity YP_614457.1 PFAM: Lysine exporter protein (LYSE/YGGA): (9.3e-06); KEGG: jan:Jann_0017 lysine exporter protein (LysE/YggA), ev=1e-49, 52% identity YP_614458.1 PFAM: OmpA/MotB: (1.8e-24); KEGG: sil:SPO3756 OmpA domain protein, ev=5e-53, 39% identity YP_614459.1 TIGRFAM: Alkylhydroperoxidase AhpD core: (6.5e-11) Uncharacterised peroxidase-related: (2.6e-83); PFAM: Carboxymuconolactone decarboxylase: (0.0017); KEGG: sil:SPO3757 alkylhydroperoxidase AhpD family core domain protein, ev=3e-86, 83% identity YP_614460.1 PFAM: GCN5-related N-acetyltransferase: (1.3e-12); KEGG: sil:SPO3758 acetyltransferase, GNAT family, ev=1e-73, 57% identity YP_614461.1 PFAM: molybdopterin binding domain: (3.9e-42); KEGG: sil:SPO3759 molybdenum cofactor biosynthesis domain protein, ev=1e-112, 84% identity YP_614462.1 Regulatory factor involved in maltose metabolism YP_614463.1 KEGG: sil:SPO3761 methionine aminopeptidase, type I, ev=1e-135, 85% identity; TIGRFAM: methionine aminopeptidase, type I: (4.2e-113); PFAM: peptidase M24: (1.1e-71) YP_614464.1 PFAM: conserved hypothetical protein 95: (9.1e-67); KEGG: sil:SPO3738 methyltransferase, , ev=7e-67, 69% identity YP_614465.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (9.2e-27); KEGG: sil:SPO3737 pyridine nucleotide-disulphide oxidoreductase family protein, ev=0.0, 80% identity YP_614466.1 PFAM: Redoxin: (1.7e-46); KEGG: rsp:RSP_0899 AhpC/TSA family protein, ev=1e-65, 73% identity YP_614467.1 KEGG: mag:amb1972 hypothetical protein, ev=8e-13, 23% identity YP_614468.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction YP_614469.1 PFAM: protein of unknown function DUF482: (6.7e-195); KEGG: sil:SPO3732 hypothetical protein, ev=0.0, 77% identity YP_614470.1 PFAM: glycerophosphoryl diester phosphodiesterase: (1.4e-17); KEGG: sil:SPO3731 glycerophosphoryl diester phosphodiesterase, , ev=5e-80, 60% identity YP_614471.1 PFAM: Endoribonuclease L-PSP: (4.2e-17); KEGG: sil:SPO3730 endoribonuclease L-PSP family protein, ev=4e-59, 75% identity YP_614472.1 TIGRFAM: Type I secretion membrane fusion protein, HlyD: (6.2e-108); PFAM: secretion protein HlyD: (5.2e-33); KEGG: sil:SPO3729 type I secretion membrane fusion protein, HlyD family, ev=1e-160, 68% identity YP_614473.1 KEGG: sil:SPO3728 type I secretion system ATPase, ev=0.0, 69% identity; TIGRFAM: Type I secretion system ATPase, PrtD: (1.9e-250); PFAM: ABC transporter related: (6e-59); SMART: ATPase: (2.2e-15) YP_614474.1 PFAM: VacJ-like lipoprotein: (3.9e-54); KEGG: sil:SPO3727 VacJ lipoprotein, , ev=1e-76, 57% identity YP_614475.1 PFAM: toluene tolerance: (6.8e-14); KEGG: sil:SPO3726 toluene tolerance family protein, ev=9e-57, 58% identity YP_614476.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_614477.1 PFAM: protein of unknown function DUF6, transmembrane: (1.5e-05); KEGG: sil:SPO0261 membrane protein, , ev=4e-86, 58% identity YP_614478.1 PFAM: helix-turn-helix motif: (7.3e-16) Cupin 2, conserved barrel: (6e-13); KEGG: sil:SPO3313 DNA-binding protein, , ev=1e-67, 68% identity YP_614479.1 TIGRFAM: benzoate transporter: (2.4e-116); PFAM: Benzoate membrane transport protein: (9e-168) Xanthine/uracil/vitamin C permease: (0.0057); KEGG: plu:plu0511 unnamed protein product; highly similar to benzoate membrane transport protein, ev=1e-103, 51% identity YP_614480.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_614481.1 KEGG: sil:SPO3318 hypothetical protein, ev=1e-138, 83% identity YP_614482.1 PFAM: glycosyl transferase, family 14: (1.1e-05); KEGG: sil:SPO3319 EpsK domain protein, ev=0.0, 75% identity YP_614483.1 KEGG: mag:amb2748 hypothetical protein, ev=2e-45, 41% identity YP_614484.1 PFAM: protein of unknown function DUF1523: (1.1e-18); KEGG: sil:SPO3320 hypothetical protein, ev=1e-84, 68% identity YP_614485.1 PFAM: creatinase: (1.9e-60) peptidase M24: (1.3e-53); KEGG: sil:SPO3327 creatinase, ev=0.0, 83% identity YP_614486.1 KEGG: rsp:RSP_1010 possible esterase/lipase/thioesterase, ev=4e-74, 56% identity YP_614487.1 KEGG: sil:SPO3328 succinate-semialdehyde dehydrogenase, ev=0.0, 79% identity; TIGRFAM: succinic semialdehyde dehydrogenase: (2.6e-302); PFAM: aldehyde dehydrogenase: (1.4e-222) YP_614488.1 PFAM: globin: (0.00031); KEGG: sil:SPO3329 globin domain protein, ev=3e-18, 40% identity YP_614489.1 KEGG: rsp:RSP_1753 hypothetical protein, ev=0.0, 59% identity YP_614490.1 PFAM: protein of unknown function DUF6, transmembrane: (1.2e-07); KEGG: vch:VCA1010 hypothetical protein, ev=8e-66, 46% identity YP_614491.1 PFAM: regulatory protein, TetR: (1.5e-15); KEGG: mtc:MT1047 transcriptional regulator, TetR family, ev=7e-10, 43% identity YP_614492.1 PFAM: heat shock protein Hsp20: (7.2e-18); KEGG: sil:SPO3484 heat shock protein, Hsp20 family, ev=5e-63, 76% identity YP_614493.1 PFAM: peptidase S1 and S6, chymotrypsin/Hap: (3.1e-06); KEGG: sil:SPO3482 trypsin domain protein, ev=6e-82, 62% identity YP_614494.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding: (0.0022) protein of unknown function DUF224, cysteine-rich region: (3.7e-17); KEGG: sil:SPO3480 glycolate oxidase, iron-sulfur subunit, ev=0.0, 85% identity YP_614495.1 PFAM: FAD linked oxidase-like: (2.1e-09); KEGG: sil:SPO3479 glycolate oxidase, GlcE subunit, ev=1e-125, 66% identity YP_614496.1 PFAM: FAD linked oxidase-like: (2.7e-68); KEGG: sil:SPO3478 glycolate oxidase, GlcD subunit, ev=0.0, 86% identity YP_614497.1 PFAM: protein of unknown function DUF599: (7.3e-28); KEGG: sil:SPO3477 hypothetical protein, ev=4e-84, 64% identity YP_614498.1 KEGG: sil:SPO3476 hypothetical protein, ev=3e-39, 67% identity YP_614499.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_614500.1 PFAM: Iojap-related protein: (5.9e-34); KEGG: sil:SPO0219 iojap-related protein, ev=1e-45, 73% identity YP_614501.1 PFAM: MscS Mechanosensitive ion channel: (5.2e-49); KEGG: sil:SPO0218 mechanosensitive ion channel family protein, ev=1e-172, 66% identity YP_614502.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_614503.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_614505.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_614506.1 KEGG: ret:RHE_CH02814 adenylate cyclase protein, ev=2e-53, 38% identity YP_614507.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_614508.1 PFAM: ribosomal protein L35: (2e-14); KEGG: sil:SPO3599 ribosomal protein L35, ev=4e-29, 95% identity YP_614510.1 PFAM: pyruvate kinase: (1.1e-141); KEGG: sil:SPO3600 pyruvate kinase, ev=0.0, 86% identity YP_614511.1 PFAM: Alcohol dehydrogenase, zinc-binding: (6.2e-33) Alcohol dehydrogenase GroES-like: (2.2e-16); KEGG: sil:SPO0231 alcohol dehydrogenase, zinc-containing, ev=1e-142, 76% identity YP_614512.1 TIGRFAM: RpsU-divergently transcribed: (2.1e-62); PFAM: COQ9: (2e-39); KEGG: sil:SPO0230 hypothetical protein, ev=2e-85, 69% identity YP_614513.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_614514.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_614515.1 PFAM: short-chain dehydrogenase/reductase SDR: (1.4e-05); KEGG: sil:SPO3638 oxidoreductase, short chain dehydrogenase/reductase family, ev=8e-90, 66% identity YP_614516.1 TIGRFAM: K+-dependent Na+/Ca+ exchanger related-protein: (2.9e-56); PFAM: sodium/calcium exchanger membrane region: (1.8e-43); KEGG: sil:SPO3639 K+-dependent Na+/Ca+ exchanger related-protein, ev=1e-134, 78% identity YP_614517.1 PFAM: peptidase S49: (2.1e-33); KEGG: sil:SPO3640 peptidase, family S49, ev=1e-115, 77% identity YP_614518.1 PFAM: ABC-2 type transporter: (4.8e-39); KEGG: sil:SPO3641 ABC transporter, permease protein, ev=1e-122, 83% identity YP_614519.1 PFAM: ABC transporter related: (2.3e-60); SMART: ATPase: (4.9e-19); KEGG: sil:SPO3642 ABC transporter, ATP-binding protein, ev=1e-129, 76% identity YP_614520.1 PFAM: carbon monoxide dehydrogenase subunit G: (2.3e-47); KEGG: sil:SPO1517 carbon monoxide dehydrogenase operon G protein, ev=2e-58, 68% identity YP_614521.1 PFAM: L-carnitine dehydratase/bile acid-inducible protein F: (3.8e-51); KEGG: sil:SPO3647 CAIB/BAIF family protein, ev=1e-136, 67% identity YP_614522.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_614523.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_614524.1 PFAM: glycoside hydrolase, family 25: (1.1e-81); KEGG: sil:SPO3258 glycosyl hydrolase, family 25, ev=2e-90, 57% identity YP_614525.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_614526.1 PFAM: short-chain dehydrogenase/reductase SDR: (4.6e-08); KEGG: sil:SPO3654 7-alpha-hydroxysteroid dehydrogenase, , ev=1e-103, 72% identity YP_614527.1 PFAM: methyltransferase small: (1.5e-65) Methyltransferase type 11: (0.0022); KEGG: sil:SPO3655 methyltransferase, , ev=4e-95, 57% identity YP_614528.1 PFAM: ATP-dependent Clp protease adaptor protein ClpS: (4.2e-49); KEGG: sil:SPO3656 ATP-dependent Clp protease, adaptor protein ClpS, ev=2e-46, 78% identity YP_614529.1 PFAM: Haloacid dehalogenase-like hydrolase: (2.6e-09); KEGG: sil:SPO3657 hydrolase, haloacid delahogenase-like family, ev=2e-86, 67% identity YP_614530.1 PFAM: beta-lactamase: (0.0012) peptidase S11, D-alanyl-D-alanine carboxypeptidase 1: (1.8e-70); KEGG: sil:SPO3658 D-alanyl-D-alanine carboxypeptidase family protein, ev=1e-158, 60% identity YP_614531.1 TIGRFAM: cytochrome oxidase maturation protein, cbb3-type: (2.7e-21); PFAM: cytochrome oxidase maturation protein cbb3-type: (1.8e-22); KEGG: sil:SPO3519 cytochrome oxidase maturation protein, cbb3-type, ev=3e-17, 76% identity YP_614532.1 TIGRFAM: ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter: (7.2e-21) ATPase, P type cation/copper-transporter: (5.4e-172) Heavy metal translocating P-type ATPase: (6.7e-182); PFAM: Haloacid dehalogenase-like hydrolase: (1.3e-22) Heavy metal transport/detoxification protein: (1.3e-11) E1-E2 ATPase-associated region: (2.7e-68); KEGG: sil:SPO3520 copper-translocating P-type ATPase, ev=0.0, 76% identity YP_614533.1 PFAM: FixH: (1.5e-52); KEGG: sil:SPO3521 FixH protein, , ev=3e-55, 71% identity YP_614534.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding: (0.0038); KEGG: sil:SPO3522 iron-sulfur-binding protein, RdxA/RdxB/FixG family, ev=0.0, 80% identity YP_614535.1 PFAM: regulatory protein, LysR: (2.6e-17) LysR, substrate-binding: (5.5e-31); KEGG: jan:Jann_4071 transcriptional regulator, LysR family, ev=3e-52, 43% identity YP_614536.1 TIGRFAM: cytochrome c oxidase, cbb3-type, subunit III: (1.3e-149); PFAM: cytochrome c, class I: (8.3e-09); KEGG: sil:SPO3523 cytochrome c oxidase, cbb3-type, subunit III, ev=1e-125, 71% identity YP_614537.1 PFAM: Cbb3-type cytochrome oxidase component: (1.8e-23); KEGG: sil:SPO3524 cytochrome c oxidase, cbb3-type, subunit IV, ev=6e-20, 81% identity YP_614538.1 CcoO; FixO YP_614539.1 CcoN; FixN YP_614540.1 PFAM: UspA: (2.9e-19); KEGG: sil:SPO3527 universal stress protein family protein, ev=4e-83, 54% identity YP_614541.1 PFAM: cyclic nucleotide-binding: (5.5e-15) regulatory protein, Crp: (3.1e-11); KEGG: sil:SPO3531 transcriptional activator protein FnrL, ev=1e-113, 84% identity YP_614542.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_614543.1 PFAM: ABC transporter related: (1.1e-61) Oligopeptide/dipeptide ABC transporter-like: (2e-06); SMART: ATPase: (6.9e-20); KEGG: sil:SPO3534 oligopeptide/dipeptide uptake family ABC transporter, ATP-binding protein, ev=0.0, 78% identity YP_614544.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.2e-48); KEGG: sil:SPO3535 oligopeptide/dipeptide uptake family ABC transporter, permease protein, ev=1e-174, 80% identity YP_614545.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.4e-47); KEGG: rsp:RSP_0703 ABC peptide transporter, inner membrane subunit, ev=1e-165, 79% identity YP_614546.1 PFAM: extracellular solute-binding protein, family 5: (1.9e-48); KEGG: sil:SPO3537 oligopeptide/dipeptide uptake family ABC transporter, periplasmic substrate-binding protein, ev=1e-179, 51% identity YP_614547.1 PFAM: cytochrome c, class I: (2.6e-18); KEGG: sil:SPO3538 cytochrome c552, ev=2e-54, 65% identity YP_614548.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_614549.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.096); PFAM: protein of unknown function DUF839: (5.7e-240); KEGG: jan:Jann_1898 protein of unknown function DUF839, ev=0.0, 63% identity YP_614550.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_614551.1 PFAM: protein of unknown function DUF1491: (3.4e-17); KEGG: rsp:RSP_1677 hypothetical protein, ev=1e-39, 75% identity YP_614552.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_614553.1 KEGG: sil:SPO3198 ribonuclease III, ev=3e-89, 76% identity; TIGRFAM: Ribonuclease III: (1.5e-100); PFAM: ribonuclease III: (2e-34) double-stranded RNA binding: (3.1e-16) YP_614554.1 KEGG: sil:SPO3199 signal peptidase I, ev=1e-127, 77% identity; TIGRFAM: Peptidase S26A, signal peptidase I: (9e-54); PFAM: peptidase S24, S26A and S26B: (2e-22) YP_614555.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_614556.1 KEGG: jan:Jann_0517 hypothetical protein, ev=6e-06, 28% identity YP_614557.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_614558.1 KEGG: sil:SPO3202 hypothetical protein, ev=5e-75, 62% identity YP_614559.1 KEGG: sil:SPO3203 guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, , ev=0.0, 87% identity; TIGRFAM: RelA/SpoT family protein: (6.2e-237); PFAM: TGS: (1.5e-26) metal-dependent phosphohydrolase, HD subdomain: (7.3e-12) RelA/SpoT: (3.7e-48); SMART: Metal-dependent phosphohydrolase, HD region: (7.5e-14) YP_614560.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_614561.1 TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase: (9.6e-30); PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK: (6.2e-24); KEGG: sil:SPO3205 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase, ev=2e-46, 50% identity YP_614562.1 PFAM: protein of unknown function DUF88: (6e-81); KEGG: sil:SPO3206 hypothetical protein, ev=9e-99, 94% identity YP_614563.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_614564.1 PFAM: Lysine exporter protein (LYSE/YGGA): (2.5e-27); KEGG: jan:Jann_0505 lysine exporter protein (LysE/YggA), ev=9e-80, 73% identity YP_614565.1 KEGG: sil:SPO3210 membrane protein, , ev=7e-56, 67% identity YP_614566.1 PFAM: Methyltransferase type 11: (7e-20) Methyltransferase type 12: (2e-18); KEGG: sil:SPO3211 hypothetical protein, ev=3e-49, 52% identity YP_614567.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_614568.1 PFAM: protein of unknown function UPF0126: (3.3e-12); KEGG: sil:SPO3213 membrane protein, , ev=2e-80, 73% identity YP_614569.1 KEGG: sil:SPO3214 hypothetical protein, ev=1e-21, 62% identity YP_614570.1 KEGG: sil:SPO3215 hypothetical protein, ev=9e-29, 73% identity YP_614571.1 TIGRFAM: methionyl-tRNA formyltransferase: (2.5e-102); PFAM: formyl transferase-like: (4.3e-52); KEGG: sil:SPO3216 methionyl-tRNA formyltransferase, ev=1e-133, 78% identity YP_614572.1 PFAM: formylmethionine deformylase: (2.1e-35); KEGG: sil:SPO3217 peptide deformylase, ev=6e-81, 90% identity YP_614573.1 PFAM: formylmethionine deformylase: (2e-45); KEGG: sil:SPO3218 peptide deformylase, ev=3e-40, 51% identity YP_614574.1 PFAM: formylmethionine deformylase: (2.5e-71); KEGG: sil:SPO3219 peptide deformylase, ev=6e-85, 88% identity YP_614575.1 PFAM: aminotransferase, class I and II: (1.2e-40); KEGG: sil:SPO3220 aminotransferase, classes I and II, ev=1e-167, 71% identity YP_614576.1 KEGG: sil:SPO3221 hypothetical protein, ev=6e-32, 63% identity YP_614577.1 KEGG: sil:SPO3222 glutathione S-transferase, ev=1e-150, 73% identity YP_614578.1 PFAM: aminotransferase, class I and II: (1.1e-08); KEGG: sil:SPO3224 cobalamin biosynthetic protein CobC, ev=1e-117, 66% identity YP_614579.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_614580.1 TIGRFAM: Lytic murein transglycosylase: (6.1e-120); PFAM: Peptidoglycan-binding domain 1: (2.5e-08); KEGG: sil:SPO3226 hypothetical protein, ev=1e-163, 71% identity YP_614581.1 TIGRFAM: Chromosome segregation protein SMC: (4.6e-247); PFAM: SMC protein-like: (6.6e-85) SMCs flexible hinge: (2e-10); KEGG: sil:SPO3228 SMC protein, ev=0.0, 75% identity YP_614582.1 PFAM: aminotransferase, class I and II: (3.2e-14); KEGG: sil:SPO3230 aminotransferase, classes I and II, ev=1e-162, 72% identity YP_614583.1 PFAM: regulatory protein GntR, HTH: (3.8e-24) GntR-like: (1.1e-37); KEGG: sil:SPO3231 pyruvate dehydrogenase complex repressor, ev=2e-98, 70% identity YP_614584.1 PFAM: ABC transporter related: (7e-31); SMART: ATPase: (2.2e-09); KEGG: chy:CHY_2116 phosphate ABC transporter, ATP-binding protein PstB, ev=5e-38, 34% identity YP_614585.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B is part of the membrane proton channel. YP_614586.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B' is part of the membrane proton channel. YP_614587.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_614588.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_614589.1 KEGG: sil:SPO3237 ATP synthase F0, subunit I, ev=2e-30, 63% identity YP_614590.1 PFAM: protein of unknown function DUF6, transmembrane: (1.3e-17); KEGG: mlo:mlr1585 hypothetical protein, ev=1e-42, 33% identity YP_614591.1 PFAM: regulatory protein, ArsR: (1.8e-11); KEGG: sil:SPO3238 transcriptional regulator, ArsR family, ev=5e-46, 87% identity YP_614592.1 PFAM: protein of unknown function DUF6, transmembrane: (5.2e-11); KEGG: sil:SPO3239 integral membrane protein, ev=1e-113, 70% identity YP_614593.1 PFAM: regulatory protein, LysR: (5.8e-14) LysR, substrate-binding: (6.3e-32); KEGG: sil:SPO3240 transcriptional regulator, LysR family, ev=1e-123, 73% identity YP_614594.1 PFAM: NAD(P)H dehydrogenase (quinone): (5.5e-35) NADPH-dependent FMN reductase: (0.0045); KEGG: jan:Jann_0760 (acyl-carrier protein) phosphodiesterase, ev=2e-62, 61% identity YP_614595.1 PFAM: YbaK/prolyl-tRNA synthetase associated region: (6.4e-05); KEGG: sil:SPO3242 YbaK/prolyl-tRNA synthetase domain protein, ev=1e-60, 65% identity YP_614597.1 KEGG: sil:SPO3246 signal recognition particle protein, ev=0.0, 87% identity; TIGRFAM: signal recognition particle protein: (9.9e-247); PFAM: GTP-binding signal recognition particle SRP54, G-domain: (1.4e-98) Signal peptide binding (SRP54) M-domain: (6.5e-40); SMART: ATPase: (1.1e-09) YP_614598.1 PFAM: GCN5-related N-acetyltransferase: (1.3e-07); KEGG: jan:Jann_3667 GCN5-related N-acetyltransferase, ev=9e-34, 46% identity YP_614599.1 KEGG: sil:SPO3251 hypothetical protein, ev=1e-100, 83% identity YP_614600.1 catalyzes the interconversion of chorismate to prephenate YP_614601.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_614602.1 TIGRFAM: Cob(II)yrinic acid a,c-diamide reductase: (2.1e-116); PFAM: nitroreductase: (1.7e-20); KEGG: sil:SPO3254 cobalamin biosynthesis protein BluB, ev=5e-82, 70% identity YP_614603.1 Essential for efficient processing of 16S rRNA YP_614605.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_614607.1 PFAM: protein of unknown function DUF1508: (4.9e-23); KEGG: nmu:Nmul_A2168 protein of unknown function DUF1508, ev=1e-36, 67% identity YP_614608.1 PFAM: regulatory protein, MerR: (1.8e-10); KEGG: sil:SPO3734 transcriptional regulator, MerR family, ev=3e-39, 56% identity YP_614609.1 PFAM: major facilitator superfamily MFS_1: (2.9e-36); KEGG: sil:SPO3735 major facilitator family protein, ev=2e-98, 52% identity YP_614610.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_614611.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_614612.1 KEGG: sil:SPO0689 chromosome partitioning protein, ev=1e-124, 84% identity YP_614613.1 PFAM: adenylyl cyclase class-3/4/guanylyl cyclase: (1.8e-09); KEGG: sil:SPO0688 adenylate/guanylate cyclase, ev=1e-108, 51% identity YP_614614.1 PFAM: regulatory protein, MarR: (1.5e-10); KEGG: sil:SPO0687 transcriptional regulator, MarR family, ev=1e-45, 64% identity YP_614615.1 An oxygenase that acts to open the ring of homogentisate formingmaleylacetoacetate as part of the catabolism of L-tyrosine and L-phenylalanine YP_614616.1 KEGG: sil:SPO0685 fumarylacetoacetase, ev=1e-169, 70% identity; TIGRFAM: fumarylacetoacetase: (3.8e-197); PFAM: fumarylacetoacetate (FAA) hydrolase: (1.7e-69) YP_614617.1 PFAM: beta-lactamase-like: (3.9e-08); KEGG: sil:SPO0683 metallo-beta-lactamase family protein, ev=1e-173, 93% identity YP_614618.1 PFAM: monooxygenase, FAD-binding: (5.2e-47) FAD dependent oxidoreductase: (0.00024); KEGG: sil:SPO0682 monooxygenase family protein, ev=0.0, 75% identity YP_614619.1 KEGG: sil:SPO0681 hypothetical protein, ev=2e-15, 70% identity YP_614620.1 TIGRFAM: maleylacetoacetate isomerase: (6.9e-93); PFAM: glutathione S-transferase-like: (3e-16); KEGG: sil:SPO0679 maleylacetoacetate isomerase, ev=5e-76, 65% identity YP_614621.1 PFAM: protein of unknown function UPF0052 and CofD: (3.6e-22); KEGG: dde:Dde_3600 hypothetical protein, ev=2e-84, 45% identity YP_614622.1 KEGG: sil:SPO3725 penicillin-binding protein, 1A family, ev=0.0, 64% identity; TIGRFAM: Penicillin-binding protein 1A: (1.9e-182); PFAM: glycosyl transferase, family 51: (2.8e-67) penicillin-binding protein, transpeptidase: (1.1e-29) YP_614623.1 PFAM: nitrogen regulatory protein P-II: (2.7e-63); KEGG: jan:Jann_4056 nitrogen regulatory protein P-II (GlnB, GlnK), ev=4e-45, 82% identity YP_614624.1 TIGRFAM: ammonium transporter: (6.3e-135); PFAM: Rh-like protein/ammonium transporter: (2.2e-128); KEGG: jan:Jann_4057 ammonium transporter, ev=0.0, 78% identity YP_614625.1 PFAM: ribonuclease T2: (3.3e-08); KEGG: sil:SPO3567 ribonuclease T2 family protein, ev=2e-90, 72% identity YP_614626.1 PFAM: protein of unknown function DUF1013: (4.5e-87); KEGG: sil:SPO3566 hypothetical protein, ev=1e-119, 83% identity YP_614628.1 PFAM: Rhodanese-like: (7.5e-26); KEGG: sil:SPO3719 thiosulfate sulfurtransferase, , ev=1e-138, 81% identity YP_614629.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_614630.1 PFAM: Enoyl-CoA hydratase/isomerase: (2.2e-22); KEGG: sil:SPO3439 enoyl-CoA hydratase/isomerase family protein, ev=3e-73, 73% identity YP_614631.1 PFAM: short-chain dehydrogenase/reductase SDR: (1.4e-33); KEGG: sil:SPO3440 20-beta-hydroxysteroid dehydrogenase, , ev=9e-89, 67% identity YP_614632.1 KEGG: sil:SPO3441 hypothetical protein, ev=1e-119, 41% identity YP_614633.1 PFAM: peptidase U62, modulator of DNA gyrase: (3.6e-40); KEGG: sil:SPO3442 PmbA, ev=0.0, 73% identity YP_614634.1 PFAM: inositol monophosphatase: (9.2e-54); KEGG: sil:SPO3443 inositol monophosphatase family protein, ev=3e-86, 59% identity YP_614635.1 KEGG: sil:SPO3444 3-deoxy-D-manno-octulosonic-acid transferase, , ev=5e-81, 42% identity YP_614636.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_614637.1 KEGG: sil:SPO3446 thiol:disulfide interchange protein, DsbA family, ev=3e-80, 64% identity YP_614638.1 PFAM: protein of unknown function DUF1159: (7.1e-21); KEGG: sil:SPO3447 hypothetical protein, ev=2e-59, 68% identity YP_614639.1 TIGRFAM: A/G-specific adenine glycosylase: (6.4e-105); PFAM: helix-hairpin-helix motif: (1.5e-06) HhH-GPD: (2.4e-11); KEGG: sil:SPO3448 A/G-specific adenine glycosylase, ev=1e-154, 76% identity YP_614640.1 PFAM: fatty acid desaturase: (2e-06); KEGG: sil:SPO3449 fatty acid desaturase family protein, ev=1e-172, 73% identity YP_614641.1 PFAM: chemotaxis sensory transducer: (9e-46); KEGG: atc:AGR_C_1888 methyl-accepting chemotaxis protein McpV, ev=6e-71, 34% identity YP_614642.1 PFAM: adenylyl cyclase class-3/4/guanylyl cyclase: (9.6e-33); KEGG: sil:SPO3450 adenylate/guanylate cyclase, ev=1e-134, 57% identity YP_614643.1 PFAM: DNA methylase N-4/N-6: (4.2e-91); KEGG: sil:SPO3451 modification methylase, ev=0.0, 88% identity YP_614644.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_614646.1 KEGG: sil:SPO3453 hypothetical protein, ev=2e-26, 64% identity YP_614647.1 KEGG: sil:SPO3454 hypothetical protein, ev=2e-98, 80% identity YP_614648.1 PFAM: adenylyl cyclase class-3/4/guanylyl cyclase: (4.1e-08) protein of unknown function DUF427: (1.3e-17); KEGG: sil:SPO3455 adenylate/guanylate cyclase, ev=0.0, 62% identity YP_614649.1 PFAM: aldehyde dehydrogenase: (5e-136); KEGG: sil:SPO0235 aldehyde dehydrogenase family protein, ev=0.0, 84% identity YP_614650.1 PFAM: TrkA-N: (0.00012) Saccharopine dehydrogenase: (3.4e-81); KEGG: sil:SPO0234 hypothetical protein, ev=1e-170, 81% identity YP_614651.1 PFAM: regulatory proteins, AsnC/Lrp: (6.9e-19); KEGG: sil:SPO0233 transcriptional regulator, AsnC family, ev=2e-60, 81% identity YP_614652.1 PFAM: protein of unknown function DUF328: (2.1e-61); KEGG: sil:SPO0106 hypothetical protein, ev=5e-54, 44% identity YP_614653.1 TIGRFAM: ATP-dependent DNA helicase, RecQ family: (5.5e-169) ATP-dependent DNA helicase RecQ: (2.7e-264); PFAM: helicase-like: (7.3e-27) HRDC: (8.7e-22) DEAD/DEAH box helicase-like: (6e-34); KEGG: sil:SPO0107 ATP-dependent DNA helicase RecQ, ev=0.0, 81% identity YP_614654.1 KEGG: sil:SPO0122 YGGT family protein, ev=1e-24, 57% identity YP_614655.1 KEGG: rsp:RSP_1361 hypothetical protein, ev=3e-50, 54% identity YP_614656.1 PFAM: major facilitator superfamily MFS_1: (3.4e-13); KEGG: sil:SPO0123 membrane protein, , ev=0.0, 73% identity YP_614657.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_614658.1 KEGG: sil:SPO0125 hypothetical protein, ev=6e-56, 42% identity YP_614659.1 PFAM: protein of unknown function DUF165: (4e-28); KEGG: rsp:RSP_1365 hypothetical protein, ev=9e-83, 73% identity YP_614660.1 PFAM: Class I peptide chain release factor: (4.9e-17); KEGG: sil:SPO0127 peptidyl-tRNA hydrolase domain protein, ev=2e-56, 77% identity YP_614661.1 PFAM: peptidase S58, DmpA: (6e-38); KEGG: sil:SPO0129 peptidase, T4 family, ev=1e-135, 71% identity YP_614662.1 PFAM: protein of unknown function DUF6, transmembrane: (1.2e-15); KEGG: sil:SPO3643 integral membrane protein, ev=9e-63, 44% identity YP_614663.1 TIGRFAM: HAD-superfamily hydrolase subfamily IA, variant 3: (2.6e-06); PFAM: Haloacid dehalogenase-like hydrolase: (4.7e-06); KEGG: sil:SPO3822 HAD-superfamily hydrolase, subfamily IA, variant 1 family protein, ev=3e-71, 62% identity YP_614664.1 PFAM: ornithine cyclodeaminase/mu-crystallin: (5.8e-26) Shikimate/quinate 5-dehydrogenase: (2.3e-05); KEGG: sil:SPO3821 ornithine cyclodeaminase/mu-crystallin family protein, ev=1e-111, 66% identity YP_614665.1 PFAM: alpha/beta hydrolase fold: (4.8e-18); KEGG: sma:SAV297 alpha/beta hydrolase, ev=4e-20, 29% identity YP_614666.1 PFAM: major facilitator superfamily MFS_1: (4.2e-34); KEGG: sil:SPO3820 transmembrane transporter, major facilitator family, ev=0.0, 80% identity YP_614667.1 PFAM: AFG1-like ATPase: (2.8e-136); KEGG: sil:SPO3819 ATPase, AFG1 family, ev=1e-148, 76% identity YP_614668.1 PFAM: regulatory protein, DeoR: (2.7e-32) Helix-turn-helix, type 11: (1.5e-08); KEGG: pae:PA3583 glycerol-3-phosphate regulon repressor, ev=2e-39, 39% identity YP_614669.1 TIGRFAM: FolC bifunctional protein: (8.5e-134); PFAM: Mur ligase, middle region: (6.8e-06); KEGG: sil:SPO3818 FolC bifunctional protein, ev=0.0, 78% identity YP_614670.1 TIGRFAM: acetyl-CoA carboxylase, carboxyl transferase, beta subunit: (5.9e-129); KEGG: sil:SPO3817 acetyl-CoA carboxylase, carboxyl transferase, beta subunit, ev=1e-149, 83% identity YP_614671.1 PFAM: Abortive infection protein: (2.8e-14); KEGG: sil:SPO3816 CAAX amino terminal protease family protein, ev=3e-74, 50% identity YP_614672.1 PFAM: cyclic nucleotide-binding: (1.2e-15); KEGG: sil:SPO3815 ABC transporter, permease protein, ev=0.0, 61% identity YP_614674.1 KEGG: sil:SPO3814 hypothetical protein, ev=1e-103, 72% identity YP_614675.1 KEGG: sil:SPO3813 hypothetical protein, ev=7e-39, 64% identity YP_614676.1 KEGG: sil:SPO3311 ADA regulatory protein, , ev=1e-126, 65% identity; TIGRFAM: methylated-DNA--protein-cysteine methyltransferase: (4.4e-40); PFAM: methylated-DNA-[protein]-cysteine S-methyltransferase: (5e-36) Ada, metal-binding: (2.3e-37); SMART: Helix-turn-helix, AraC type: (1.2e-12) YP_614677.1 KEGG: sil:SPO2551 peptide/opine/nickel uptake family ABC transporter, ATP-binding protein, ev=1e-129, 73% identity; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein-like: (9.2e-24); PFAM: ABC transporter related: (6.2e-68) Oligopeptide/dipeptide ABC transporter-like: (1.5e-22); SMART: ATPase: (3.5e-21) YP_614678.1 KEGG: sil:SPO2552 peptide/opine/nickel uptake family ABC transporter, permease/ATP-binding protein, ev=0.0, 79% identity; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein-like: (6.6e-24); PFAM: binding-protein-dependent transport systems inner membrane component: (7.1e-44) ABC transporter related: (1.1e-60) Oligopeptide/dipeptide ABC transporter-like: (7.1e-25); SMART: ATPase: (2.7e-19) YP_614679.1 PFAM: binding-protein-dependent transport systems inner membrane component: (7.7e-47); KEGG: sil:SPO2553 peptide/opine/nickel uptake family ABC transporter, permease protein, ev=1e-149, 84% identity YP_614680.1 PFAM: extracellular solute-binding protein, family 5: (1.4e-89); KEGG: sil:SPO2554 peptide/opine/nickel uptake family ABC transporter, periplasmic substrate-binding protein, ev=0.0, 82% identity YP_614681.1 KEGG: sil:SPO2555 hypothetical protein, ev=4e-53, 51% identity YP_614682.1 PFAM: regulatory protein GntR, HTH: (3.8e-15) GntR-like: (8.8e-20); KEGG: sil:SPO2550 transcriptional regulator, GntR family, ev=4e-80, 61% identity YP_614683.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_614684.1 PFAM: Hemolysin-type calcium-binding region: (0.0016); KEGG: sil:SPO1626 type I secretion target repeat protein, ev=1e-67, 29% identity YP_614685.1 PFAM: aminotransferase class-III: (7.1e-80); KEGG: sil:SPO1136 aminotransferase, class III, ev=0.0, 91% identity YP_614686.1 PFAM: aldehyde dehydrogenase: (1e-212); KEGG: sil:SPO1137 succinate-semialdehyde dehydrogenase, ev=0.0, 82% identity YP_614687.1 PFAM: regulatory proteins, AsnC/Lrp: (8.7e-19); KEGG: sil:SPO1138 transcriptional regulator, AsnC family, ev=1e-73, 85% identity YP_614688.1 PFAM: Succinylglutamate desuccinylase/aspartoacylase: (3.8e-92); KEGG: sil:SPO1139 succinylglutamate desuccinylase/aspartoacylase family protein, ev=1e-161, 84% identity YP_614689.1 PFAM: helix-turn-helix, AraC type: (2.4e-08); KEGG: sil:SPO3397 transcriptional regulator, AraC family, ev=4e-29, 28% identity YP_614690.1 PFAM: CHAP: (4.9e-07); KEGG: eli:ELI_01090 hypothetical protein, ev=3e-29, 44% identity YP_614691.1 PFAM: PRC-barrel: (0.0002); KEGG: jan:Jann_2065 PRC protein, ev=1e-41, 34% identity YP_614692.1 PFAM: regulatory proteins, IclR: (6.2e-41); KEGG: jan:Jann_3261 transcriptional regulator, IclR family, ev=1e-102, 68% identity YP_614693.1 PFAM: aminotransferase, class V: (3.4e-14); KEGG: sil:SPOA0144 serine--glyoxylate transaminase, , ev=0.0, 87% identity YP_614694.1 PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit: (2.6e-56); KEGG: sil:SPOA0145 pyridoxal-phosphate dependent enzyme, ev=1e-162, 88% identity YP_614695.1 PFAM: alanine racemase-like: (1.7e-08); KEGG: sil:SPOA0146 threonine aldolase, low-specificity, ev=0.0, 83% identity YP_614696.1 PFAM: ornithine cyclodeaminase/mu-crystallin: (1.3e-43); KEGG: jan:Jann_2605 ornithine cyclodeaminase, ev=1e-153, 85% identity YP_614697.1 PFAM: regulatory protein, LysR: (1.2e-20) LysR, substrate-binding: (9e-45); KEGG: sme:SMb21291 transcriptional regulator, LysR family protein, ev=1e-104, 59% identity YP_614698.1 PFAM: ferredoxin: (2e-05) molybdopterin dehydrogenase, FAD-binding: (3.5e-70) [2Fe-2S]-binding: (1.4e-44) CO dehydrogenase flavoprotein-like: (4.6e-28); KEGG: sme:SMb21286 probable xanthine dehydrogenase protein, ev=1e-164, 59% identity YP_614699.1 PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead: (3.4e-39) aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding: (4.9e-203); KEGG: sme:SMb21287 xanthine dehydrogenase protein, ev=0.0, 73% identity YP_614700.1 PFAM: protein of unknown function DUF182: (5.2e-12); KEGG: mlo:mlr5136 xanthine dehydrogenase accessory factor, ev=4e-64, 46% identity YP_614701.1 PFAM: Xanthine/uracil/vitamin C permease: (0.00031); KEGG: bha:BH1513 hypothetical protein, ev=1e-100, 41% identity YP_614702.1 PFAM: regulatory proteins, AsnC/Lrp: (4.2e-24); KEGG: atc:AGR_L_238 hypothetical transcriptional regulator Y4TD, ev=6e-39, 49% identity YP_614703.1 PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit: (3.4e-26); KEGG: jan:Jann_1828 pyridoxal-5'-phosphate-dependent enzyme, beta subunit, ev=1e-97, 57% identity YP_614704.1 PFAM: peptidase M24: (3.3e-12); KEGG: jan:Jann_1829 peptidase M24, ev=1e-107, 53% identity YP_614705.1 PFAM: Asp/Glu racemase: (1.6e-07); KEGG: sil:SPO2450 Asp/Glu/Hydantoin racemase family protein, ev=2e-67, 54% identity YP_614706.1 PFAM: peptidase M24: (1.1e-46); KEGG: jan:Jann_2048 peptidase M24, ev=1e-122, 61% identity YP_614707.1 PFAM: extracellular solute-binding protein, family 5: (9.9e-62); KEGG: jan:Jann_2047 extracellular solute-binding protein, family 5, ev=0.0, 75% identity YP_614708.1 PFAM: helix-turn-helix motif: (8.6e-16) Cupin 2, conserved barrel: (1.6e-17); KEGG: jan:Jann_2046 transcriptional regulator, XRE family with cupin sensor domain, ev=1e-74, 66% identity YP_614709.1 PFAM: binding-protein-dependent transport systems inner membrane component: (4.4e-47); KEGG: jan:Jann_2045 binding-protein-dependent transport systems inner membrane component, ev=1e-151, 80% identity YP_614710.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1e-46); KEGG: jan:Jann_2044 binding-protein-dependent transport systems inner membrane component, ev=1e-132, 78% identity YP_614711.1 PFAM: ABC transporter related: (2e-52); SMART: ATPase: (9.8e-16); KEGG: jan:Jann_2043 ABC transporter related, ev=1e-107, 72% identity YP_614712.1 PFAM: ABC transporter related: (8.3e-61); SMART: ATPase: (1.5e-16); KEGG: jan:Jann_2042 ABC transporter related, ev=1e-103, 77% identity YP_614713.1 KEGG: jan:Jann_2041 hypothetical protein, ev=3e-35, 46% identity YP_614714.1 PFAM: protein of unknown function DUF1328: (7.8e-20); KEGG: jan:Jann_3570 protein of unknown function DUF1328, ev=3e-14, 66% identity YP_614715.1 PFAM: Ferritin and Dps: (1.2e-17); KEGG: rru:Rru_A0333 ferritin and Dps, ev=8e-31, 44% identity YP_614716.1 in Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media YP_614717.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_614718.1 PFAM: histidine kinase, dimerisation/phosphoacceptor: (1.1e-21); KEGG: jan:Jann_3564 signal transduction histidine kinase, ev=4e-82, 33% identity YP_614719.1 PFAM: Exopolysaccharide synthesis, ExoD: (6.6e-19); KEGG: jan:Jann_0449 exopolysaccharide synthesis, ExoD, ev=1e-29, 40% identity YP_614720.1 KEGG: rsp:RSP_1276 hypothetical protein, ev=2e-18, 37% identity YP_614721.1 PFAM: ammonia monooxygenase: (6.8e-17); KEGG: atc:AGR_C_342 hypothetical protein YhjN, ev=6e-49, 34% identity YP_614722.1 PFAM: Citrate synthase: (1.8e-07); KEGG: reu:Reut_B4959 citrate synthase, ev=3e-90, 65% identity YP_614723.1 PFAM: L-carnitine dehydratase/bile acid-inducible protein F: (2.3e-57); KEGG: jan:Jann_3486 L-carnitine dehydratase/bile acid-inducible protein F, ev=1e-134, 62% identity YP_614724.1 PFAM: protein of unknown function DUF112, transmembrane: (1.9e-152); KEGG: sil:SPO0184 membrane protein, , ev=0.0, 85% identity YP_614725.1 KEGG: jan:Jann_3488 hypothetical protein, ev=2e-58, 70% identity YP_614726.1 PFAM: Uncharacterized protein UPF0065: (1.4e-09); KEGG: sil:SPO0186 bordetella uptake gene family protein, ev=1e-145, 78% identity YP_614727.1 PFAM: response regulator receiver: (1e-22) transcriptional regulatory protein-like: (7.6e-17); KEGG: sil:SPO0187 DNA-binding response regulator, ev=2e-81, 69% identity YP_614728.1 PFAM: ATP-binding region, ATPase-like: (7.6e-33) histidine kinase, HAMP region: (4.3e-07) histidine kinase A-like: (5.8e-06) Two-component sensor kinase-like: (1.6e-31); KEGG: sil:SPO0188 sensor histidine kinase, ev=1e-132, 55% identity YP_614729.1 KEGG: sil:SPO0189 iron(III) transport system substrate-binding protein, ev=3e-84, 49% identity YP_614730.1 KEGG: sil:SPOA0319 transketolase, , ev=0.0, 80% identity YP_614731.1 catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine YP_614732.1 PFAM: regulatory proteins, AsnC/Lrp: (1.9e-30); KEGG: sil:SPOA0317 transcriptional regulator, AsnC family, ev=3e-66, 81% identity YP_614733.1 PFAM: glycoside hydrolase, family 20: (6.8e-138); KEGG: atc:AGR_C_4704 beta-N-acetylhexosaminidase, ev=1e-159, 47% identity YP_614734.1 PFAM: GCN5-related N-acetyltransferase: (5.2e-06); KEGG: bcl:ABC0535 hypothetical protein, ev=8e-41, 52% identity YP_614735.1 PFAM: ABC transporter related: (1.9e-48) Oligopeptide/dipeptide ABC transporter-like: (0.00011); SMART: ATPase: (1e-15); KEGG: vvy:VVA0003 ABC-type oligopeptide transport system, ATPase component, ev=2e-80, 52% identity YP_614736.1 PFAM: ABC transporter related: (5.5e-52); SMART: ATPase: (1.7e-18); KEGG: vfi:VFA0200 oligosaccharide transport ATP-binding protein, ev=1e-84, 59% identity YP_614737.1 PFAM: binding-protein-dependent transport systems inner membrane component: (8.9e-28); KEGG: ret:RHE_PE00330 peptide ABC transporter, permease protein, ev=1e-106, 63% identity YP_614738.1 PFAM: binding-protein-dependent transport systems inner membrane component: (2.9e-46); KEGG: ret:RHE_PE00331 peptide ABC transporter, permease protein, ev=1e-107, 58% identity YP_614739.1 PFAM: extracellular solute-binding protein, family 5: (5.9e-63); KEGG: ret:RHE_PE00332 peptide ABC transporter, substrate-binding protein, ev=1e-166, 51% identity YP_614740.1 PFAM: response regulator receiver: (1.7e-37) ATP-binding region, ATPase-like: (4.4e-36) histidine kinase, HAMP region: (1.8e-16) histidine kinase A-like: (6.4e-20); KEGG: vpa:VP2478 sensory box sensor histidine kinase/response regulator, ev=1e-157, 32% identity YP_614741.1 PFAM: helix-turn-helix protein RpiR: (1e-13) sugar isomerase (SIS): (1.2e-12); KEGG: bja:bll0307 transcriptional regulatory protein, ev=3e-48, 41% identity YP_614742.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component: (5.3e-12); KEGG: sme:SMb20296 permease protein, ev=4e-12, 27% identity YP_614743.1 TIGRFAM: TRAP dicarboxylate transporter- DctM subunit: (1.1e-133); PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (3.6e-131); KEGG: bcl:ABC4044 TRAP-type transport system permease large protein, ev=3e-91, 42% identity YP_614744.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit: (9e-51); PFAM: TRAP dicarboxylate transporter- DctP subunit: (3.4e-69); KEGG: mag:amb1225 TRAP-type C4-dicarboxylate transport system, ev=4e-52, 36% identity YP_614745.1 PFAM: Uncharacterised conserved protein UCP012702: (9.8e-157) MlrC-like: (1.5e-89); KEGG: bms:BRA0752 hypothetical protein, ev=1e-159, 56% identity YP_614746.1 PFAM: alanine racemase-like: (5.8e-19); KEGG: sme:SMb21134 amino acid processing enzyme, similar to low specificity D-threonine aldolase protein, ev=1e-128, 66% identity YP_614747.1 PFAM: PfkB: (3e-47); KEGG: bur:Bcep18194_A5081 sugar kinase, ribokinase family, ev=3e-75, 50% identity YP_614748.1 PFAM: Endoribonuclease L-PSP: (4.9e-36); KEGG: sme:SMb21139 protein, similar to translation initiation inhibitors, ev=4e-35, 56% identity YP_614749.1 KEGG: sil:SPO3812 carboxyl-terminal protease family protein, ev=0.0, 83% identity; TIGRFAM: carboxyl-terminal protease: (5.8e-93); PFAM: PDZ/DHR/GLGF: (1.7e-10) peptidase S41: (1e-73) YP_614750.1 PFAM: peptidase M23B: (0.00023); KEGG: sil:SPO3811 hypothetical protein, ev=1e-132, 70% identity YP_614751.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_614752.1 PFAM: protein of unknown function DUF1203: (1.3e-72); KEGG: sil:SPO3849 hypothetical protein, ev=3e-55, 66% identity YP_614753.1 PFAM: GCN5-related N-acetyltransferase: (8.4e-09); KEGG: gvi:glr3142 acetyltransferase, ev=6e-24, 39% identity YP_614754.1 PFAM: ABC transporter related: (1.8e-54); SMART: ATPase: (7e-14); KEGG: sil:SPO3847 ABC transporter, ATP-binding protein, ev=1e-146, 84% identity YP_614755.1 KEGG: sil:SPO3846 hypothetical protein, ev=2e-21, 86% identity YP_614756.1 KEGG: sil:SPO0221 hypothetical protein, ev=5e-67, 78% identity YP_614757.1 KEGG: jan:Jann_1682 hypothetical protein, ev=1e-08, 26% identity YP_614758.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_614759.1 PFAM: Xylose isomerase-like TIM barrel: (6.4e-35); KEGG: reu:Reut_A1423 hydroxypyruvate isomerase, ev=2e-52, 44% identity YP_614760.1 PFAM: protein of unknown function DUF1285: (3.1e-89); KEGG: sil:SPO0140 hypothetical protein, ev=1e-70, 67% identity YP_614761.1 PFAM: ATPase associated with various cellular activities, AAA_3: (1.6e-74) ATPase associated with various cellular activities, AAA_5: (1.1e-08); KEGG: sil:SPO0139 ATPase, MoxR family, ev=1e-152, 81% identity YP_614762.1 KEGG: sil:SPO0138 hypothetical protein, ev=1e-114, 72% identity YP_614763.1 TIGRFAM: Double-transmembrane region-like: (7.7e-15); KEGG: sil:SPO0137 hypothetical protein, ev=0.0, 62% identity YP_614764.1 KEGG: sil:SPO0136 hypothetical protein, ev=0.0, 69% identity YP_614765.1 KEGG: dar:Daro_4183 hydratase/decarboxylase, ev=6e-48, 41% identity YP_614766.1 KEGG: sil:SPO0135 penicillin-binding protein 1C, ev=0.0, 61% identity; TIGRFAM: Penicillin-binding protein 1C: (4.6e-220); PFAM: glycosyl transferase, family 51: (1.1e-62) penicillin-binding protein, transpeptidase: (4.7e-14) Penicillin-binding-like: (5.8e-10) YP_614767.1 PFAM: alpha-2-macroglobulin-like: (1.4e-45) N/apple PAN: (0.0056) alpha-2-macroglobulin-like 2: (6.9e-19); KEGG: sil:SPO0133 PAN domain protein, ev=0.0, 61% identity YP_614768.1 PFAM: response regulator receiver: (2.7e-27) ATP-binding region, ATPase-like: (4.6e-40) histidine kinase A-like: (1.3e-25); KEGG: sil:SPO0132 sensor histidine kinase/response regulator, ev=0.0, 65% identity YP_614769.1 TIGRFAM: Dihydrolipoamide dehydrogenase: (6.2e-170); PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (1.5e-29) pyridine nucleotide-disulphide oxidoreductase dimerisation region: (1.7e-30); KEGG: sme:SMc03204 dihydrolipoamide dehydrogenase, ev=1e-166, 66% identity YP_614770.1 PFAM: biotin/lipoyl attachment: (3.1e-22) catalytic domain of components of various dehydrogenase complexes: (8.5e-110) E3 binding: (1.7e-13); KEGG: mlo:mll4471 dihydrolipoamide S-(2-methylpropanoyl)transferase, ev=1e-147, 60% identity YP_614771.1 PFAM: Transketolase, central region: (7.2e-78) Transketolase-like: (4.4e-57); KEGG: mlo:mll4472 2-oxoisovalerate dehydrogenase (beta subunit), ev=1e-162, 80% identity YP_614772.1 PFAM: dehydrogenase, E1 component: (6.3e-114); KEGG: bme:BMEII0748 2-oxoisovalerate dehydrogenase alpha subunit, ev=0.0, 78% identity YP_614773.1 PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal: (1.2e-22) Glu/Leu/Phe/Val dehydrogenase, dimerisation region: (2.8e-42); KEGG: bca:BCE4237 leucine dehydrogenase, ev=8e-85, 45% identity YP_614774.1 PFAM: regulatory proteins, AsnC/Lrp: (1.8e-20); KEGG: sil:SPO0389 transcriptional regulator, AsnC family, ev=2e-33, 46% identity YP_614775.1 PFAM: iron-containing alcohol dehydrogenase: (3.2e-79); KEGG: sil:SPO2609 alcohol dehydrogenase, iron-containing, ev=1e-168, 74% identity YP_614776.1 PFAM: aldehyde dehydrogenase: (5.7e-120); KEGG: sil:SPO2608 aldehyde dehydrogenase, , ev=0.0, 71% identity YP_614777.1 PFAM: glutamine synthetase, catalytic region: (3.4e-92); KEGG: sil:SPO2607 gamma-glutamylisopropylamide synthetase, , ev=0.0, 71% identity YP_614778.1 TIGRFAM: Twin-arginine translocation pathway signal: (1.3e-05); PFAM: TRAP dicarboxylate transporter- DctP subunit: (4.3e-08); KEGG: sil:SPO2606 bacterial extracellular solute-binding protein, family 7, ev=0.0, 93% identity YP_614779.1 PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit: (3.2e-49); KEGG: sil:SPO2605 TRAP dicarboxylate transporter, DctM subunit, ev=0.0, 82% identity YP_614780.1 KEGG: sil:SPO2604 hypothetical protein, ev=1e-54, 57% identity YP_614781.1 PFAM: N-formylglutamate amidohydrolase: (1.8e-60); KEGG: atc:AGR_C_3887 similar to orf3 gene in Methylobacterium extorquens, ev=1e-57, 54% identity YP_614782.1 PFAM: helix-turn-helix protein RpiR: (3.6e-06) sugar isomerase (SIS): (1.5e-13); KEGG: sme:SMc01602 hypothetical protein, ev=4e-76, 51% identity YP_614783.1 PFAM: AMP-dependent synthetase and ligase: (1.1e-17); KEGG: rru:Rru_A2517 AMP-dependent synthetase and ligase, ev=3e-39, 36% identity YP_614784.1 PFAM: Thiolase: (1e-21); KEGG: ret:RHE_PF00014 acetyl-CoA acetyltransferase (beta-ketothiolase) protein, ev=1e-60, 41% identity YP_614785.1 KEGG: dar:Daro_3836 fungal/archaeal/bacterial haem catalase/peroxidase, ev=0.0, 72% identity; TIGRFAM: catalase/peroxidase HPI: (0); PFAM: Haem peroxidase: (1.5e-110) YP_614786.1 PFAM: regulatory protein, LysR: (2.6e-20) LysR, substrate-binding: (4.9e-45); KEGG: bja:bll0777 transcriptional regulatory protein, ev=1e-111, 70% identity YP_614787.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA YP_614788.1 PFAM: CoA-binding: (1e-08); KEGG: sil:SPOA0287 acyl-CoA synthetase, , ev=0.0, 60% identity YP_614789.1 TIGRFAM: SelT/selW/selH selenoprotein: (2e-23); PFAM: Selenoprotein W-related: (2.7e-46); KEGG: sme:SMc00345 selenoprotein W-related protein, ev=2e-29, 65% identity YP_614790.1 PFAM: acyl-CoA dehydrogenase-like: (2.7e-63) Acyl-CoA dehydrogenase, type 2-like: (5.3e-26); KEGG: mlo:mlr5042 acyl-CoA dehydrogenase, ev=0.0, 84% identity YP_614791.1 PFAM: helix-turn-helix, AraC type: (8.6e-09) ThiJ/PfpI: (2.7e-05); KEGG: sil:SPOA0289 transcriptional regulator, AraC family, ev=5e-91, 60% identity YP_614792.1 PFAM: arsenate reductase and related: (8.2e-28); KEGG: jan:Jann_2102 arsenate reductase, ev=7e-33, 56% identity YP_614793.1 KEGG: sil:SPO3746 adenine deaminase, ev=0.0, 84% identity; TIGRFAM: adenine deaminase: (4.6e-140); PFAM: amidohydrolase: (4.9e-23) YP_614794.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_614795.1 PFAM: histone-like DNA-binding protein: (2.6e-25); KEGG: sil:SPO3744 DNA-binding protein HU, ev=1e-39, 91% identity YP_614796.1 PFAM: protein of unknown function DUF6, transmembrane: (2.8e-11); KEGG: sil:SPO3743 membrane protein, , ev=1e-120, 77% identity YP_614797.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_614798.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_614799.1 PFAM: Hydantoinase/oxoprolinase: (4.2e-58) Hydantoinaseoxoprolinase-like: (1.4e-46); KEGG: sil:SPO3739 hydantoinase/oxoprolinase family protein, ev=0.0, 69% identity YP_614800.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding: (0.0006) Domain of unknown function DUF1730: (3.2e-37); KEGG: sil:SPO3763 iron-sulfur cluster-binding protein, ev=1e-160, 80% identity YP_614801.1 PFAM: beta-lactamase: (8.8e-24); KEGG: atc:AGR_C_1692 6-aminohexanoate-dimer hydrolase, ev=1e-147, 55% identity YP_614802.1 KEGG: atc:AGR_C_1694 hypothetical protein, ev=1e-152, 56% identity YP_614803.1 PFAM: diaminopimelate epimerase: (4.4e-36); KEGG: sil:SPO0278 diaminopimelate epimerase, ev=1e-121, 76% identity YP_614804.1 KEGG: sil:SPO0277 MiaB-like tRNA modifying enzyme, ev=0.0, 84% identity; TIGRFAM: MiaB-like tRNA modifying enzyme: (7.2e-170); PFAM: protein of unknown function UPF0004: (8.9e-21) Radical SAM: (1.1e-29); SMART: Elongator protein 3/MiaB/NifB: (1.7e-54) YP_614805.1 KEGG: ppr:PBPRA2780 hypothetical protein, ev=1e-25, 38% identity YP_614806.1 PFAM: cytochrome c1: (9.4e-109); KEGG: sil:SPO0273 ubiquinol--cytochrome c reductase, cytochrome c1, ev=1e-104, 66% identity YP_614807.1 PFAM: cytochrome b/b6-like: (7.8e-94); KEGG: sil:SPO0272 ubiquinol--cytochrome c reductase, cytochrome B, ev=0.0, 92% identity YP_614808.1 TIGRFAM: Twin-arginine translocation pathway signal: (3.3e-05) Ubiquinol-cytochrome c reductase, iron-sulfur subunit: (1.4e-97); PFAM: Rieske [2Fe-2S] region: (4e-18); KEGG: sil:SPO0271 ubiquinol-cytochrome c reductase, iron-sulfur subunit, ev=4e-92, 86% identity YP_614809.1 PFAM: glutathione S-transferase-like: (0.0074); KEGG: sil:SPO0270 glutathione S-transferase family protein, ev=1e-60, 55% identity YP_614810.1 PFAM: ABC transporter related: (1.9e-59); SMART: ATPase: (7.2e-18); KEGG: rsp:RSP_1393 ABC thiamine transporter, ATPase subunit, ev=3e-71, 60% identity YP_614811.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_614812.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_614813.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_614814.1 PFAM: NAD-dependent epimerase/dehydratase: (2.1e-11) 3-beta hydroxysteroid dehydrogenase/isomerase: (7e-12) dTDP-4-dehydrorhamnose reductase: (5.1e-07) NmrA-like: (0.00092) Male sterility-like: (3e-07); KEGG: sil:SPO3772 NADH ubiquinone oxidoreductase, , ev=1e-137, 74% identity YP_614815.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell YP_614816.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_614817.1 PFAM: glutamine amidotransferase, class-II: (4.8e-211) glutamate synthase, alpha subunit-like: (6.6e-94) ferredoxin-dependent glutamate synthase: (1.2e-219) glutamate synthase: (4.5e-158); KEGG: sil:SPO3768 glutamate synthase, large subunit, ev=0.0, 88% identity YP_614818.1 TIGRFAM: Monofunctional biosynthetic peptidoglycan transglycosylase: (2.2e-78); PFAM: glycosyl transferase, family 51: (2.8e-66); KEGG: sil:SPO3766 monofunctional biosynthetic peptidoglycan transglycosylase, ev=3e-84, 70% identity YP_614819.1 PFAM: glutathione S-transferase-like: (4.1e-10); KEGG: sil:SPO3764 glutathione S-transferase family protein, ev=1e-110, 85% identity YP_614820.1 PFAM: HemY-like: (2.7e-22); KEGG: sil:SPO3851 HemY domain protein, ev=0.0, 69% identity YP_614821.1 KEGG: sil:SPO3852 hypothetical protein, ev=1e-87, 44% identity YP_614822.1 PFAM: Uroporphyrinogen III synthase HEM4: (1.6e-07); KEGG: sil:SPO3853 uroporphyrinogen-III synthase, , ev=2e-39, 41% identity YP_614823.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_614824.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_614825.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_614826.1 PFAM: protein of unknown function DUF589: (3.7e-77); KEGG: sil:SPO3857 hypothetical protein, ev=2e-63, 77% identity YP_614827.1 KEGG: sil:SPO3858 hypothetical protein, ev=2e-43, 60% identity YP_614828.1 KEGG: sil:SPO3859 hypothetical protein, ev=2e-51, 88% identity YP_614829.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_614830.1 PFAM: metal-dependent phosphohydrolase, HD subdomain: (4.7e-07); KEGG: jan:Jann_4073 metal dependent phosphohydrolase, ev=7e-87, 75% identity YP_614831.1 KEGG: sil:SPO3864 hypothetical protein, ev=1e-142, 63% identity YP_614832.1 PFAM: response regulator receiver: (4e-23); KEGG: sil:SPO3865 photosynthetic apparatus regulatory protein RegA, ev=8e-89, 89% identity YP_614833.1 PFAM: electron transport protein SCO1/SenC: (5.6e-30); KEGG: sil:SPO3866 regulatory protein SenC, ev=5e-85, 74% identity YP_614834.1 PFAM: ATP-binding region, ATPase-like: (2.8e-21) histidine kinase A-like: (9.9e-10); KEGG: sil:SPO3867 sensor histidine kinase RegB, ev=0.0, 67% identity YP_614835.1 KEGG: sil:SPO3868 hypothetical protein, ev=1e-149, 53% identity YP_614836.1 PFAM: protein of unknown function UPF0079: (6.3e-37); KEGG: sil:SPO3869 conserved hypothetical protein TIGR00150, ev=4e-41, 52% identity YP_614837.1 PFAM: aminoglycoside phosphotransferase: (5.2e-27); KEGG: sil:SPO3870 hypothetical protein, ev=4e-89, 53% identity YP_614838.1 PFAM: Nucleotidyl transferase: (9.7e-07); KEGG: sil:SPO3871 nucleotidyltransferase family protein, ev=7e-66, 53% identity YP_614839.1 KEGG: sil:SPO3872 hypothetical protein, ev=0.0, 65% identity YP_614840.1 PFAM: UvrD/REP helicase: (7.6e-49); KEGG: sil:SPO3873 ATP-dependent DNA helicase, UvrD/Rep family, ev=0.0, 68% identity YP_614841.1 TIGRFAM: thioredoxin: (9.2e-52); PFAM: glutaredoxin: (0.0003) Thioredoxin domain: (2.8e-47); KEGG: sil:SPO3874 thioredoxin, ev=7e-52, 92% identity YP_614842.1 PFAM: protein of unknown function DUF1127: (3.6e-11); KEGG: jan:Jann_0963 protein of unknown function DUF1127, ev=3e-06, 64% identity YP_614843.1 heat shock protein involved in degradation of misfolded proteins YP_614844.1 KEGG: jan:Jann_0186 hypothetical protein, ev=2e-82, 50% identity YP_614845.1 heat shock protein involved in degradation of misfolded proteins YP_614846.1 PFAM: protein of unknown function DUF900, hydrolase-like: (3.4e-45); KEGG: sil:SPO3883 lipoprotein, , ev=3e-95, 53% identity YP_614847.1 PFAM: Smr protein/MutS2: (4.1e-17); KEGG: sil:SPO3884 smr domain protein, ev=4e-73, 69% identity YP_614848.1 PFAM: MltA: (2e-74) 3D: (3.7e-32); KEGG: sil:SPO3885 MltA/3D domain protein, ev=1e-138, 69% identity YP_614849.1 PFAM: import inner membrane translocase, subunit Tim44: (1.9e-44); KEGG: sil:SPO3886 transporter, Tim44 family, ev=2e-81, 68% identity YP_614850.1 PFAM: FxsA cytoplasmic membrane protein: (7e-33); KEGG: sil:SPO3887 FxsA, ev=8e-60, 72% identity YP_614851.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_614852.1 KEGG: sil:SPO3889 DNA polymerase III, epsilon subunit, ev=1e-103, 75% identity; TIGRFAM: DNA polymerase III, epsilon subunit: (5.6e-44); PFAM: Exonuclease, RNase T and DNA polymerase III: (6.1e-36); SMART: Exonuclease: (4e-41) YP_614853.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_614854.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_614855.1 PFAM: Maf-like protein: (1.3e-25); KEGG: sil:SPO3892 Maf, ev=6e-70, 66% identity YP_614856.1 PFAM: conserved hypothetical protein 701: (6.3e-64); KEGG: sil:SPO3893 membrane protein, , ev=2e-62, 74% identity YP_614857.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_614858.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_614859.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_614860.1 TIGRFAM: methyltransferase GidB: (2.2e-38); PFAM: glucose inhibited division protein: (3e-38); KEGG: sil:SPO0002 glucose-inhibited division protein B, ev=1e-67, 62% identity YP_614861.1 PFAM: Cobyrinic acid a,c-diamide synthase: (2.3e-57); KEGG: sil:SPO0003 chromosome partitioning protein ParA, ev=1e-118, 81% identity YP_614862.1 TIGRFAM: parB-like partition proteins: (9.4e-55); PFAM: ParB-like nuclease: (8.4e-37); KEGG: sil:SPO0004 chromosome partitioning protein ParB, ev=1e-110, 70% identity YP_614863.1 PFAM: protein of unknown function DUF454: (6.8e-12); KEGG: sil:SPO0005 hypothetical protein, ev=6e-43, 70% identity YP_614864.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_614865.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_614866.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_614867.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_614868.1 PFAM: GrpE protein: (2e-50); KEGG: sil:SPO0010 co-chaperone GrpE, ev=6e-84, 82% identity YP_614869.1 This protein performs the mismatch recognition step during the DNA repair process YP_614870.1 PFAM: flagellin-like: (7.4e-07); KEGG: ccr:CC0793 flagellin FljN, ev=5e-33, 32% identity YP_614871.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_614872.1 PFAM: PfkB: (2.6e-32); KEGG: sil:SPO0013 ribokinase, ev=1e-105, 65% identity YP_614873.1 KEGG: sil:SPO0014 methionine-S-sulfoxide reductase, ev=7e-78, 66% identity; TIGRFAM: peptide methionine sulfoxide reductase: (4.7e-55); PFAM: Methionine sulfoxide reductase A: (1.5e-60) YP_614874.1 PFAM: Sterol-binding: (1.4e-08); KEGG: sil:SPO0016 sterol carrier family protein, ev=9e-29, 66% identity YP_614875.1 PFAM: protein of unknown function DUF1036: (2.3e-41); KEGG: bja:blr7137 hypothetical protein, ev=2e-26, 44% identity YP_614876.1 KEGG: sil:SPO0017 hypothetical protein, ev=3e-47, 63% identity YP_614877.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_614878.1 KEGG: jan:Jann_0068 hypothetical protein, ev=2e-27, 30% identity YP_614879.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_614880.1 PFAM: Hpt: (6.2e-11); KEGG: sil:SPO0021 Hpt domain protein, ev=8e-29, 63% identity YP_614881.1 PFAM: response regulator receiver: (3.3e-38) Stage II sporulation E: (1.8e-34); SMART: Protein phosphatase 2C-like: (1.8e-14); KEGG: sil:SPO0022 response regulator, ev=1e-177, 71% identity YP_614882.1 PFAM: NUDIX hydrolase: (1e-18); KEGG: sil:SPO0023 hydrolase, NUDIX family, ev=3e-54, 70% identity YP_614883.1 PFAM: Hsp33 protein: (7.3e-53); KEGG: sil:SPO0024 chaperonin, 33 kDa, ev=1e-158, 84% identity YP_614884.1 PFAM: NUDIX hydrolase: (2.6e-12); KEGG: sil:SPO0025 hydrolase, NUDIX family, ev=4e-66, 66% identity YP_614885.1 PFAM: Polynucleotide adenylyltransferase region: (3.3e-38); KEGG: sil:SPO0026 polyA polymerase family protein, ev=1e-127, 62% identity YP_614886.1 PFAM: ABC transporter, transmembrane region: (4.1e-07) ABC transporter related: (6.1e-60); SMART: ATPase: (8.2e-22); KEGG: sil:SPO0027 ABC transporter, transmembrane ATP-binding protein, ev=0.0, 82% identity YP_614887.1 PFAM: ABC transporter, transmembrane region: (6.9e-06) ABC transporter related: (7e-54); SMART: ATPase: (2.3e-20); KEGG: sil:SPO0028 ABC transporter, transmembrane ATP-binding protein, ev=0.0, 70% identity YP_614888.1 PFAM: (Uracil-5)-methyltransferase: (0.0026); KEGG: sil:SPO0029 23S rRNA (uracil-5-)-methyltransferase RumA, ev=1e-160, 68% identity YP_614889.1 PFAM: Ion transport protein: (2.1e-34); KEGG: sil:SPO0030 voltage-gated sodium channel, ev=1e-106, 74% identity YP_614890.1 PFAM: ErfK/YbiS/YcfS/YnhG: (4e-05); KEGG: sil:SPO0031 ErfK/YbiS/YcfS/YnhG family protein, ev=1e-60, 70% identity YP_614891.1 PFAM: Allergen V5/Tpx-1 related: (1.4e-10); KEGG: sil:SPO0076 lipoprotein, , ev=9e-52, 63% identity YP_614892.1 TIGRFAM: Twin-arginine translocation pathway signal: (0.15); PFAM: ErfK/YbiS/YcfS/YnhG: (3e-47); KEGG: sil:SPO0075 ErfK/YbiS/YcfS/YnhG family protein/Tat domain protein, ev=6e-86, 72% identity YP_614893.1 KEGG: sil:SPO0074 hypothetical protein, ev=1e-16, 73% identity YP_614894.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_614895.1 KEGG: sil:SPO0072 hypothetical protein, ev=1e-90, 62% identity YP_614896.1 KEGG: sil:SPO0071 competence protein F, , ev=1e-80, 61% identity YP_614897.1 TIGRFAM: Glutaredoxin, GrxC: (2.4e-49); PFAM: glutaredoxin: (3e-25); KEGG: sil:SPO0070 glutaredoxin, ev=4e-32, 74% identity YP_614898.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase: (4.1e-40); KEGG: sil:SPO0069 hydrolase, carbon-nitrogen family, ev=1e-101, 67% identity YP_614899.1 PFAM: regulatory protein, MarR: (3.4e-08); KEGG: sil:SPO0068 transcriptional regulator, , ev=2e-54, 72% identity YP_614900.1 Involved in ubiquinone biosynthesis YP_614901.1 KEGG: sil:SPO0066 proline iminopeptidase, ev=1e-153, 78% identity; TIGRFAM: proline iminopeptidase: (9.6e-155); PFAM: alpha/beta hydrolase fold: (4.6e-23) YP_614902.1 KEGG: sil:SPO0065 peptide/opine/nickel uptake family ABC transporter, periplasmic substrate-binding protein, ev=8e-76, 53% identity YP_614903.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_614904.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_614905.1 PFAM: protein of unknown function DUF448: (1.6e-28); KEGG: sil:SPO0062 hypothetical protein, ev=3e-84, 74% identity YP_614906.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_614908.1 TIGRFAM: mutator mutT protein: (1.9e-31); PFAM: NUDIX hydrolase: (1.4e-23); KEGG: sil:SPO0060 mutator MutT protein, ev=2e-64, 87% identity YP_614909.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_614910.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase: (6.9e-33); KEGG: sil:SPO0058 PPIC-type PPIASE domain protein, ev=1e-85, 56% identity YP_614911.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_614912.1 KEGG: jan:Jann_0288 hypothetical protein, ev=3e-32, 35% identity YP_614913.1 PFAM: OmpA/MotB: (0.00021); KEGG: sil:SPO0055 OmpA domain protein, ev=0.0, 67% identity YP_614914.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_614915.1 PFAM: Polyprenyl synthetase: (3.4e-68); KEGG: rsp:RSP_1135 geranylgeranyl pyrophosphate synthetase, ev=2e-93, 65% identity YP_614916.1 TIGRFAM: exodeoxyribonuclease VII, small subunit: (3.1e-25); PFAM: Exonuclease VII, small subunit: (1.3e-27); KEGG: sil:SPO0249 exodeoxyribonuclease VII, small subunit, ev=6e-27, 85% identity YP_614917.1 PFAM: histone deacetylase superfamily: (1.9e-82); KEGG: sil:SPO0250 histone deacetylase family protein, ev=1e-139, 77% identity YP_614918.1 PFAM: response regulator receiver: (6.4e-37) transcriptional regulatory protein-like: (4e-21); KEGG: sil:SPO0251 DNA-binding response regulator PetR, ev=1e-108, 84% identity YP_614919.1 PFAM: regulatory protein, MarR: (1.2e-07); KEGG: sil:SPO0252 transcriptional regulator PetP, ev=5e-71, 79% identity YP_614920.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_614921.1 PFAM: OsmC-like protein: (1.1e-32); KEGG: sil:SPO0254 organic hydroperoxide resistance protein, ev=1e-50, 67% identity YP_614922.1 PFAM: regulatory protein, MarR: (8.1e-20); KEGG: sil:SPO0255 transcriptional regulator, MarR family, ev=3e-44, 61% identity YP_614923.1 PFAM: protein of unknown function DUF6, transmembrane: (4e-07) UAA transporter: (0.0036); KEGG: sil:SPO0263 membrane protein, ev=1e-113, 65% identity YP_614924.1 PFAM: cation efflux protein: (0.00014); KEGG: bja:bll4927 hypothetical protein, ev=7e-72, 66% identity YP_614925.1 PFAM: regulatory protein, MerR: (3e-11); KEGG: sil:SPOA0389 transcriptional regulator, MerR family, ev=5e-39, 56% identity YP_614926.1 PFAM: NAD-dependent epimerase/dehydratase: (0.0014) dTDP-4-dehydrorhamnose reductase: (0.0033); KEGG: sil:SPO3755 hypothetical protein, ev=1e-102, 64% identity YP_614927.1 KEGG: jan:Jann_2250 hypothetical protein, ev=2e-64, 50% identity YP_614928.1 PFAM: periplasmic binding protein: (3.5e-10); KEGG: jan:Jann_2249 periplasmic binding protein, ev=1e-106, 63% identity YP_614929.1 PFAM: transport system permease protein: (6e-92); KEGG: jan:Jann_2248 transport system permease protein, ev=1e-114, 62% identity YP_614930.1 PFAM: ABC transporter related: (3.4e-51); SMART: ATPase: (4.8e-09); KEGG: jan:Jann_2247 ABC transporter related, ev=1e-69, 55% identity YP_614931.1 PFAM: histidine kinase, HAMP region: (1.5e-06) chemotaxis sensory transducer: (1.2e-62); KEGG: atc:AGR_C_678 methyl-accepting chemotaxis protein McpT, ev=4e-75, 34% identity YP_614932.1 PFAM: OmpA/MotB: (2.3e-05); KEGG: sil:SPO0191 chemotaxis protein MotB, ev=3e-91, 60% identity YP_614933.1 PFAM: flagellar basal body rod protein: (6.7e-09) protein of unknown function DUF1078-like: (9.9e-17); KEGG: sil:SPO0192 flagellar hook protein FlgE, , ev=1e-133, 56% identity YP_614934.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_614935.1 KEGG: sil:SPO0194 flagellar hook-associated protein FlgL family protein, ev=4e-58, 37% identity YP_614936.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_614938.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_614939.1 PFAM: surface presentation of antigens (SPOA) protein: (3.4e-10); KEGG: sil:SPO0197 flagellar motor switch protein FliN, ev=5e-34, 79% identity YP_614940.1 KEGG: sil:SPO0198 ABC transporter, ATP-binding protein, flagellar, , ev=2e-45, 46% identity YP_614941.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_614942.1 PFAM: flagellar basal body-associated protein FliL: (1.2e-13); KEGG: sil:SPO0200 flagellar basal body-associated protein FliL, ev=1e-40, 50% identity YP_614943.1 KEGG: sil:SPO0201 hypothetical protein, ev=9e-40, 59% identity YP_614944.1 KEGG: sil:SPO0202 hypothetical protein, ev=2e-51, 57% identity YP_614945.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_614946.1 KEGG: sil:SPO0204 hypothetical protein, ev=1e-77, 28% identity YP_614947.1 membrane protein involved in the flagellar export apparatus YP_614948.1 KEGG: sil:SPO0171 flagellar biosynthetic protein FliR, ev=1e-70, 51% identity YP_614949.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_614950.1 KEGG: sil:SPO0173 hypothetical protein, ev=2e-19, 38% identity YP_614951.1 KEGG: sil:SPO0174 hypothetical protein, ev=2e-38, 45% identity YP_614952.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_614953.1 required for the assembly of the flagellar basal body P-ring YP_614954.1 makes up the distal portion of the flagellar basal body rod; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thick flagella YP_614955.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; Rhodobacter sphaeroides has 2 copies of this and other flagella genes YP_614956.1 PFAM: export protein FliQ, family 3: (3.9e-14); KEGG: sil:SPO0179 flagellar biosynthetic protein FliQ, ev=5e-27, 65% identity YP_614957.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_614958.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_614959.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod YP_614960.1 KEGG: sil:SPO0183 H+-transporting two-sector ATPase, flagellum-specific, ev=1e-169, 68% identity; TIGRFAM: ATP synthase FliI/YscN: (6.8e-133); PFAM: H+-transporting two-sector ATPase, alpha/beta subunit, central region: (9.4e-97); SMART: ATPase: (2.1e-08) YP_614961.1 PFAM: transposase IS3/IS911: (1.6e-20); KEGG: atc:AGR_L_545 insertion element ISR1 hypothetical 10 KD protein A3, ev=3e-25, 67% identity YP_614962.1 PFAM: Integrase, catalytic region: (3.3e-31); KEGG: jan:Jann_3728 integrase protein, ev=1e-100, 76% identity YP_614963.1 PFAM: transposase IS3/IS911: (2.9e-19); KEGG: ret:RHE_PA00090 probable insertion sequence transposase protein, IS3/IS911 family, ev=2e-34, 77% identity YP_614964.1 PFAM: Integrase, catalytic region: (4.6e-37); KEGG: mlo:mll6088 transposase, ev=1e-117, 75% identity YP_614965.1 KEGG: sil:SPO3456 flagellar protein, , ev=4e-43, 33% identity YP_614966.1 post-transcriptional repressor of flagellum biosynthesis; promotes degradation of fljK mRNA: Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_614967.1 acts as an activator of flagellin translation and may be required for filament secretion or assembly; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thick flagellum YP_614968.1 PFAM: flagellin-like: (1.6e-06); KEGG: sil:SPO3459 flagellin protein, ev=5e-47, 55% identity YP_614969.1 KEGG: sil:SPO3460 hypothetical protein, ev=3e-24, 51% identity YP_614970.1 KEGG: sil:SPO3461 flagellar protein FlgJ, , ev=8e-22, 55% identity YP_614971.1 KEGG: sil:SPO3462 flagellar hook-length control protein, ev=7e-20, 24% identity YP_614972.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Rhodobacter sphaeroides has 2 copies of many flagellar genes; the Rhodobacter protein in this cluster is associated with a set of flagellar genes acquired by lateral gene transfer; these genes are not normally expressed YP_614973.1 PFAM: aminoglycoside phosphotransferase: (1.4e-19); KEGG: sil:SPO3464 hypothetical protein, ev=1e-61, 50% identity YP_614974.1 PFAM: FAD dependent oxidoreductase: (5.5e-71); KEGG: sil:SPO3465 hypothetical protein, ev=1e-150, 60% identity YP_614975.1 PFAM: binding-protein-dependent transport systems inner membrane component: (1.3e-11); KEGG: sil:SPO3466 putrescine ABC transporter, permease protein, ev=1e-129, 87% identity YP_614976.1 PFAM: binding-protein-dependent transport systems inner membrane component: (8.5e-21); KEGG: sil:SPO3467 putrescine ABC transporter, permease protein, ev=1e-145, 85% identity YP_614977.1 KEGG: sil:SPO3468 putrescine ABC transporter, ATP-binding protein, ev=1e-170, 80% identity; TIGRFAM: spermidine/putrescine ABC transporter ATP-binding subunit: (3e-149); PFAM: ABC transporter related: (1.6e-58) Transport-associated OB: (4.4e-21); SMART: ATPase: (7.7e-19) YP_614978.1 PFAM: extracellular solute-binding protein, family 1: (2.3e-06); KEGG: sil:SPO3469 putrescine ABC transporter, periplasmic putrescine-binding protein, ev=1e-153, 72% identity YP_614979.1 PFAM: regulatory protein GntR, HTH: (3.1e-13) GntR-like: (1.2e-09); KEGG: sil:SPO3470 transcriptional regulator, GntR family, ev=9e-71, 65% identity YP_614980.1 PFAM: aminotransferase class-III: (4.2e-109); KEGG: sil:SPO3471 aminotransferase, class III, ev=0.0, 82% identity YP_614981.1 KEGG: sil:SPO3472 polyamine ABC transporter, ATP-binding protein, ev=0.0, 87% identity; TIGRFAM: spermidine/putrescine ABC transporter ATP-binding subunit: (1.2e-140); PFAM: ABC transporter related: (7.6e-59) Transport-associated OB: (6.3e-19); SMART: ATPase: (3.7e-16) YP_614982.1 KEGG: jan:Jann_1267 polyamine ABC trasnporter, periplasmic polyamine-binding protein, ev=1e-153, 68% identity YP_614983.1 PFAM: binding-protein-dependent transport systems inner membrane component: (3.2e-18); KEGG: jan:Jann_1269 binding-protein-dependent transport systems inner membrane component, ev=0.0, 63% identity YP_614984.1 PFAM: binding-protein-dependent transport systems inner membrane component: (2e-11); KEGG: jan:Jann_1271 binding-protein-dependent transport systems inner membrane component, ev=1e-120, 70% identity YP_614985.1 TIGRFAM: Lytic murein transglycosylase: (2.9e-148); PFAM: Peptidoglycan-binding domain 1: (1e-07); KEGG: sil:SPO3488 peptidoglycan binding domain protein, ev=1e-146, 62% identity YP_614986.1 PFAM: Helix-turn-helix, type 11: (6.8e-17); KEGG: sil:SPO3487 hypothetical protein, ev=1e-74, 65% identity YP_614987.1 KEGG: sil:SPO3486 hypothetical protein, ev=4e-40, 42% identity YP_614988.1 KEGG: sil:SPO3330 ribonuclease R, ev=0.0, 79% identity; TIGRFAM: VacB and RNase II family 3'-5' exoribonucleases: (1.2e-145) Ribonuclease R: (6.3e-259); PFAM: ribonuclease II: (3.2e-79) RNA binding S1: (1.7e-10) YP_614989.1 PFAM: GCN5-related N-acetyltransferase: (2.8e-17); KEGG: rsp:RSP_1127 acetyltransferase, GNAT family, ev=2e-33, 54% identity YP_614990.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_614991.1 KEGG: sil:SPO3334 hypothetical protein, ev=7e-92, 48% identity YP_614992.1 PFAM: extracellular solute-binding protein, family 3: (1.1e-20); SMART: Ionotropic glutamate receptor: (7.4e-09); KEGG: sil:SPO3335 glutamine ABC transporter, periplasmic glutamine-binding protein, ev=1e-114, 62% identity YP_614993.1 KEGG: sil:SPO3336 hypothetical protein, ev=2e-45, 83% identity YP_614994.1 KEGG: sil:SPO3333 hypothetical protein, ev=1e-127, 47% identity YP_614995.1 PFAM: regulatory protein GntR, HTH: (1.4e-07) UbiC transcription regulator-associated: (2.2e-27); KEGG: sil:SPO1369 transcriptional regulator, GntR family, ev=6e-74, 59% identity YP_614996.1 PFAM: protein of unknown function DUF886: (4.4e-11); KEGG: sil:SPO2147 hypothetical protein, ev=7e-20, 43% identity YP_614997.1 catalyzes the deimination of N-formimino-L-glutamate to ammonia and N-formyl-L-glutamate YP_614998.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_614999.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_615000.1 PFAM: N-formylglutamate amidohydrolase: (1.7e-88); KEGG: atc:AGR_L_1827 N-formylglutamate amidohydrolase, ev=2e-94, 64% identity YP_615001.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_615002.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (2.9e-05); KEGG: mca:MCA2808 hypothetical protein, ev=8e-16, 34% identity YP_615003.2 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_615004.1 PFAM: regulatory protein GntR, HTH: (1.2e-14) GntR-like: (1.5e-05); KEGG: sil:SPO3340 transcriptional regulator, GntR family, ev=6e-65, 61% identity YP_615005.1 catalyzes the formation of 2-oxobutanoate from L-threonine YP_615006.1 PFAM: conserved hypothetical protein 730: (3e-58); KEGG: sil:SPO3342 decarboxylase family protein, ev=1e-119, 74% identity YP_615007.1 KEGG: sil:SPO3343 hypothetical protein, ev=1e-12, 55% identity YP_615008.1 TIGRFAM: conserved hypothetical protein: (1.2e-137); PFAM: Radical SAM: (3.2e-20); KEGG: sil:SPO3346 radical SAM enzyme, Cfr family, ev=0.0, 89% identity YP_615009.1 KEGG: sil:SPO3348 hypothetical protein, ev=3e-65, 69% identity YP_615010.1 PFAM: L-asparaginase II: (2.3e-103); KEGG: sil:SPO3349 L-asparaginase, thermolabile family, ev=1e-122, 65% identity YP_615011.1 PFAM: DGPFAETKE: (4.8e-06); KEGG: sil:SPO3350 hypothetical protein, ev=8e-37, 70% identity YP_615012.1 PFAM: protein of unknown function DUF81: (1.4e-31); KEGG: mlo:mlr1193 hypothetical protein, ev=1e-78, 58% identity YP_615013.1 KEGG: sil:SPO3353 phosphoserine phosphatase, ev=1e-131, 80% identity; TIGRFAM: phosphoserine phosphatase SerB: (4.2e-73) HAD-superfamily hydrolase subfamily IB, PSPase-like: (2.2e-39); PFAM: Haloacid dehalogenase-like hydrolase: (2.4e-15) YP_615014.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate YP_615015.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_615016.1 PFAM: metallophosphoesterase: (4.5e-13); KEGG: sil:SPO3358 serine/threonine protein phosphatase family protein, ev=8e-81, 58% identity YP_615017.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_615018.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_615019.1 PFAM: helix-turn-helix motif: (2.6e-17) Cupin 2, conserved barrel: (0.0048); KEGG: sil:SPO0141 DNA binding protein, , ev=2e-73, 79% identity YP_615020.1 catalyzes the formation of beta-ketovaleryl-CoA from acetyl-CoA and propionyl-CoA YP_615021.1 TIGRFAM: 2-polyprenylphenol 6-hydroxylase: (2.9e-202); PFAM: ABC-1: (5.1e-44); KEGG: sil:SPO0144 2-polyprenylphenol 6-hydroxylase, ev=0.0, 82% identity YP_615022.1 TIGRFAM: ubiquinone/menaquinone biosynthesis methyltransferases: (3.1e-122); PFAM: UbiE/COQ5 methyltransferase: (6e-119) Methyltransferase type 11: (4.7e-25) Methyltransferase type 12: (4.4e-13); KEGG: sil:SPO0145 ubiquinone/menaquinone biosynthesis methyltransferase UbiE, ev=1e-130, 89% identity YP_615023.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_615024.1 PFAM: Enoyl-CoA hydratase/isomerase: (4.1e-74); KEGG: sil:SPO0147 enoyl-CoA hydratase, ev=1e-116, 80% identity YP_615025.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase