-- dump date 20140620_033339 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_001492846.1 157825126 5645715 1..822 1 NC_009881.1 COG1806 Uncharacterized protein conserved in bacteria; hypothetical protein 822 5645715 A1C_00005 Rickettsia akari str. Hartford hypothetical protein YP_001492846.1 1 D 293614 CDS YP_001492847.1 157825127 5645496 964..1383 1 NC_009881.1 COG0526 Thiol-disulfide isomerase and thioredoxins; thioredoxin 1383 5645496 A1C_00010 Rickettsia akari str. Hartford thioredoxin YP_001492847.1 964 D 293614 CDS YP_001492848.1 157825128 5645245 1389..2138 1 NC_009881.1 COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component; O-antigen export system ATP-binding protein RfbE 2138 5645245 A1C_00015 Rickettsia akari str. Hartford O-antigen export system ATP-binding protein RfbE YP_001492848.1 1389 D 293614 CDS YP_001492849.1 157825129 5645246 2139..2915 1 NC_009881.1 COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component; O-antigen export system permease protein RfbA 2915 5645246 A1C_00020 Rickettsia akari str. Hartford O-antigen export system permease protein RfbA YP_001492849.1 2139 D 293614 CDS YP_001492850.1 157825130 5645247 2912..5983 1 NC_009881.1 undetermined function; putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase 5983 5645247 A1C_00025 Rickettsia akari str. Hartford putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase YP_001492850.1 2912 D 293614 CDS YP_001492851.1 157825131 5645248 complement(6021..6737) 1 NC_009881.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 6737 5645248 A1C_00030 Rickettsia akari str. Hartford UDP-N-acetylglucosamine acyltransferase YP_001492851.1 6021 R 293614 CDS YP_001492852.1 157825132 5644862 complement(6725..6814) 1 NC_009881.1 (3R)-hydroxymyristoyl-ACP dehydratase 6814 fabZ 5644862 fabZ Rickettsia akari str. Hartford (3R)-hydroxymyristoyl-ACP dehydratase YP_001492852.1 6725 R 293614 CDS YP_001492853.1 157825133 5644863 6801..6926 1 NC_009881.1 hypothetical protein 6926 5644863 A1C_00040 Rickettsia akari str. Hartford hypothetical protein YP_001492853.1 6801 D 293614 CDS YP_001492854.1 157825134 5644864 complement(6824..7261) 1 NC_009881.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 7261 fabZ 5644864 fabZ Rickettsia akari str. Hartford (3R)-hydroxymyristoyl-ACP dehydratase YP_001492854.1 6824 R 293614 CDS YP_001492855.1 157825135 5644865 complement(7480..8520) 1 NC_009881.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 8520 lpxD 5644865 lpxD Rickettsia akari str. Hartford UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_001492855.1 7480 R 293614 CDS YP_001492856.1 157825136 5644866 8972..9427 1 NC_009881.1 alpha/beta hydrolase superfamily esterase 9427 5644866 A1C_00055 Rickettsia akari str. Hartford alpha/beta hydrolase superfamily esterase YP_001492856.1 8972 D 293614 CDS YP_001492857.1 157825137 5644867 complement(9637..9768) 1 NC_009881.1 hypothetical protein 9768 5644867 A1C_00060 Rickettsia akari str. Hartford hypothetical protein YP_001492857.1 9637 R 293614 CDS YP_001492858.1 157825138 5644868 complement(10272..12848) 1 NC_009881.1 COG0542 ATPases with chaperone activity, ATP-binding subunit; clpB protein 12848 5644868 A1C_00065 Rickettsia akari str. Hartford clpB protein YP_001492858.1 10272 R 293614 CDS YP_001492859.1 157825139 5644728 14156..14263 1 NC_009881.1 hypothetical protein 14263 5644728 A1C_00080 Rickettsia akari str. Hartford hypothetical protein YP_001492859.1 14156 D 293614 CDS YP_001492860.1 157825140 5644729 14247..14372 1 NC_009881.1 hypothetical protein 14372 5644729 A1C_00085 Rickettsia akari str. Hartford hypothetical protein YP_001492860.1 14247 D 293614 CDS YP_001492861.1 157825141 5644730 14481..14696 1 NC_009881.1 hypothetical protein 14696 5644730 A1C_00090 Rickettsia akari str. Hartford hypothetical protein YP_001492861.1 14481 D 293614 CDS YP_001492862.1 157825142 5644731 14696..15421 1 NC_009881.1 catalyzes the conversion of 3-hydroxyacyl-CoA to 3-oxyacyl-CoA; acetoacetyl-CoA reductase 15421 5644731 A1C_00095 Rickettsia akari str. Hartford acetoacetyl-CoA reductase YP_001492862.1 14696 D 293614 CDS YP_001492863.1 157825143 5644732 15625..16116 1 NC_009881.1 hypothetical protein 16116 5644732 A1C_00100 Rickettsia akari str. Hartford hypothetical protein YP_001492863.1 15625 D 293614 CDS YP_001492864.1 157825144 5644733 16130..17452 1 NC_009881.1 hypothetical protein 17452 5644733 A1C_00105 Rickettsia akari str. Hartford hypothetical protein YP_001492864.1 16130 D 293614 CDS YP_001492865.1 157825145 5644734 17683..17907 1 NC_009881.1 hypothetical protein 17907 5644734 A1C_00110 Rickettsia akari str. Hartford hypothetical protein YP_001492865.1 17683 D 293614 CDS YP_001492866.1 157825146 5644934 17931..18044 1 NC_009881.1 COG2337 Growth inhibitor; hypothetical protein 18044 5644934 A1C_00115 Rickettsia akari str. Hartford hypothetical protein YP_001492866.1 17931 D 293614 CDS YP_001492867.1 157825147 5644935 complement(18710..18874) 1 NC_009881.1 cell surface antigen-like protein Sca10 18874 5644935 A1C_00120 Rickettsia akari str. Hartford cell surface antigen-like protein Sca10 YP_001492867.1 18710 R 293614 CDS YP_001492868.1 157825148 5644936 complement(18801..19340) 1 NC_009881.1 COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit; cell surface antigen-like protein Sca10 19340 5644936 A1C_00125 Rickettsia akari str. Hartford cell surface antigen-like protein Sca10 YP_001492868.1 18801 R 293614 CDS YP_001492869.1 157825149 5644937 complement(19433..19570) 1 NC_009881.1 cell surface antigen-like protein Sca10 19570 5644937 A1C_00130 Rickettsia akari str. Hartford cell surface antigen-like protein Sca10 YP_001492869.1 19433 R 293614 CDS YP_001492870.1 157825150 5644938 complement(19767..20153) 1 NC_009881.1 cell surface antigen-like protein Sca10 20153 5644938 A1C_00135 Rickettsia akari str. Hartford cell surface antigen-like protein Sca10 YP_001492870.1 19767 R 293614 CDS YP_001492871.1 157825151 5644939 20251..20529 1 NC_009881.1 hypothetical protein 20529 5644939 A1C_00140 Rickettsia akari str. Hartford hypothetical protein YP_001492871.1 20251 D 293614 CDS YP_001492872.1 157825152 5644940 complement(20543..20659) 1 NC_009881.1 hypothetical protein 20659 5644940 A1C_00145 Rickettsia akari str. Hartford hypothetical protein YP_001492872.1 20543 R 293614 CDS YP_001492873.1 157825153 5645566 complement(21109..21303) 1 NC_009881.1 cell surface antigen-like protein Sca10 21303 5645566 A1C_00150 Rickettsia akari str. Hartford cell surface antigen-like protein Sca10 YP_001492873.1 21109 R 293614 CDS YP_001492874.1 157825154 5645567 complement(21471..21629) 1 NC_009881.1 cell surface antigen-like protein Sca10 21629 5645567 A1C_00155 Rickettsia akari str. Hartford cell surface antigen-like protein Sca10 YP_001492874.1 21471 R 293614 CDS YP_001492875.1 157825155 5645568 complement(22115..22783) 1 NC_009881.1 COG1286 Uncharacterized membrane protein, required for colicin V production; hypothetical protein 22783 5645568 A1C_00160 Rickettsia akari str. Hartford hypothetical protein YP_001492875.1 22115 R 293614 CDS YP_001492876.1 157825156 5645569 23018..23587 1 NC_009881.1 COG1678 Putative transcriptional regulator; hypothetical protein 23587 5645569 A1C_00165 Rickettsia akari str. Hartford hypothetical protein YP_001492876.1 23018 D 293614 CDS YP_001492877.1 157825157 5645570 complement(23598..24173) 1 NC_009881.1 COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems; Sco2 protein precursor 24173 5645570 A1C_00170 Rickettsia akari str. Hartford Sco2 protein precursor YP_001492877.1 23598 R 293614 CDS YP_001492878.1 157825158 5645571 24487..24720 1 NC_009881.1 hypothetical protein 24720 5645571 A1C_00175 Rickettsia akari str. Hartford hypothetical protein YP_001492878.1 24487 D 293614 CDS YP_001492879.1 157825159 5645572 24707..24823 1 NC_009881.1 hypothetical protein 24823 5645572 A1C_00180 Rickettsia akari str. Hartford hypothetical protein YP_001492879.1 24707 D 293614 CDS YP_001492880.1 157825160 5644671 25742..26197 1 NC_009881.1 COG0457 FOG: TPR repeat; hypothetical protein 26197 5644671 A1C_00185 Rickettsia akari str. Hartford hypothetical protein YP_001492880.1 25742 D 293614 CDS YP_001492881.1 157825161 5644672 26340..26573 1 NC_009881.1 hypothetical protein 26573 5644672 A1C_00190 Rickettsia akari str. Hartford hypothetical protein YP_001492881.1 26340 D 293614 CDS YP_001492882.1 157825162 5644673 26701..27369 1 NC_009881.1 hypothetical protein 27369 5644673 A1C_00195 Rickettsia akari str. Hartford hypothetical protein YP_001492882.1 26701 D 293614 CDS YP_001492883.1 157825163 5644674 27564..27875 1 NC_009881.1 COG1539 Dihydroneopterin aldolase; folate synthesis bifunctional protein 27875 5644674 A1C_00200 Rickettsia akari str. Hartford folate synthesis bifunctional protein YP_001492883.1 27564 D 293614 CDS YP_001492884.1 157825164 5644675 28224..28364 1 NC_009881.1 COG0262 Dihydrofolate reductase; dihydrofolate reductase 28364 5644675 A1C_00205 Rickettsia akari str. Hartford dihydrofolate reductase YP_001492884.1 28224 D 293614 CDS YP_001492885.1 157825165 5644676 29260..30342 1 NC_009881.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 30342 recF 5644676 recF Rickettsia akari str. Hartford recombination protein F YP_001492885.1 29260 D 293614 CDS YP_001492886.1 157825166 5644677 30588..32192 1 NC_009881.1 COG0500 SAM-dependent methyltransferases; hypothetical protein 32192 5644677 A1C_00225 Rickettsia akari str. Hartford hypothetical protein YP_001492886.1 30588 D 293614 CDS YP_001492887.1 157825167 5645537 32199..32345 1 NC_009881.1 hypothetical protein 32345 5645537 A1C_00230 Rickettsia akari str. Hartford hypothetical protein YP_001492887.1 32199 D 293614 CDS YP_001492888.1 157825168 5645538 complement(32402..32935) 1 NC_009881.1 COG1329 Transcriptional regulators, similar to M. xanthus CarD; transcriptional regulator 32935 5645538 A1C_00235 Rickettsia akari str. Hartford transcriptional regulator YP_001492888.1 32402 R 293614 CDS YP_001492889.1 157825169 5645539 33114..34052 1 NC_009881.1 COG1651 Protein-disulfide isomerase; protein-disulfide isomerase 34052 5645539 A1C_00240 Rickettsia akari str. Hartford protein-disulfide isomerase YP_001492889.1 33114 D 293614 CDS YP_001492890.1 157825170 5645540 34211..34468 1 NC_009881.1 COG5336 Uncharacterized protein conserved in bacteria; hypothetical protein 34468 5645540 A1C_00245 Rickettsia akari str. Hartford hypothetical protein YP_001492890.1 34211 D 293614 CDS YP_001492891.1 157825171 5645541 34465..35193 1 NC_009881.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 35193 5645541 A1C_00250 Rickettsia akari str. Hartford F0F1 ATP synthase subunit A YP_001492891.1 34465 D 293614 CDS YP_001492892.1 157825172 5645542 35388..35612 1 NC_009881.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 35612 5645542 A1C_00255 Rickettsia akari str. Hartford F0F1 ATP synthase subunit C YP_001492892.1 35388 D 293614 CDS YP_001492893.1 157825173 5645543 35630..36103 1 NC_009881.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel.; F0F1 ATP synthase subunit B' 36103 5645543 A1C_00260 Rickettsia akari str. Hartford F0F1 ATP synthase subunit B' YP_001492893.1 35630 D 293614 CDS YP_001492894.1 157825174 5644780 36103..36597 1 NC_009881.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 36597 5644780 A1C_00265 Rickettsia akari str. Hartford F0F1 ATP synthase subunit B YP_001492894.1 36103 D 293614 CDS YP_001492895.1 157825175 5644781 complement(36698..36808) 1 NC_009881.1 hypothetical protein 36808 5644781 A1C_00270 Rickettsia akari str. Hartford hypothetical protein YP_001492895.1 36698 R 293614 CDS YP_001492896.1 157825176 5644782 complement(37122..37631) 1 NC_009881.1 COG0459 Chaperonin GroEL (HSP60 family); hypothetical protein 37631 5644782 A1C_00275 Rickettsia akari str. Hartford hypothetical protein YP_001492896.1 37122 R 293614 CDS YP_001492897.1 157825177 5644784 complement(38026..42537) 1 NC_009881.1 cell surface antigen 42537 5644784 A1C_00280 Rickettsia akari str. Hartford cell surface antigen YP_001492897.1 38026 R 293614 CDS YP_001492898.1 157825178 5644785 43287..43862 1 NC_009881.1 COG0658 Predicted membrane metal-binding protein; ComEC/Rec2 family protein 43862 5644785 A1C_00285 Rickettsia akari str. Hartford ComEC/Rec2 family protein YP_001492898.1 43287 D 293614 CDS YP_001492899.1 157825179 5645723 44125..44382 1 NC_009881.1 ComEC/Rec2-like protein 44382 5645723 A1C_00290 Rickettsia akari str. Hartford ComEC/Rec2-like protein YP_001492899.1 44125 D 293614 CDS YP_001492900.1 157825180 5645724 44786..45943 1 NC_009881.1 COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; Poly(A) polymerase 45943 5645724 A1C_00295 Rickettsia akari str. Hartford Poly(A) polymerase YP_001492900.1 44786 D 293614 CDS YP_001492901.1 157825181 5645725 46006..46845 1 NC_009881.1 COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin; zinc/manganese ABC transporter substrate binding protein 46845 5645725 A1C_00300 Rickettsia akari str. Hartford zinc/manganese ABC transporter substrate binding protein YP_001492901.1 46006 D 293614 CDS YP_001492902.1 157825182 5645726 46833..47348 1 NC_009881.1 COG0802 Predicted ATPase or kinase; hypothetical protein 47348 5645726 A1C_00305 Rickettsia akari str. Hartford hypothetical protein YP_001492902.1 46833 D 293614 CDS YP_001492903.1 157825183 5645727 complement(47353..47550) 1 NC_009881.1 antitoxin of toxin-antitoxin system StbD 47550 5645727 A1C_00310 Rickettsia akari str. Hartford antitoxin of toxin-antitoxin system StbD YP_001492903.1 47353 R 293614 CDS YP_001492904.1 157825184 5645728 complement(47579..48535) 1 NC_009881.1 hypothetical protein 48535 5645728 A1C_00315 Rickettsia akari str. Hartford hypothetical protein YP_001492904.1 47579 R 293614 CDS YP_001492905.1 157825185 5645729 complement(48532..49515) 1 NC_009881.1 COG0042 tRNA-dihydrouridine synthase; nifR3 family TIM-barrel protein 49515 5645729 A1C_00320 Rickettsia akari str. Hartford nifR3 family TIM-barrel protein YP_001492905.1 48532 R 293614 CDS YP_001492906.1 157825186 5645314 complement(50123..50449) 1 NC_009881.1 COG1943 Transposase and inactivated derivatives; transposase IS200-family protein 50449 5645314 A1C_00325 Rickettsia akari str. Hartford transposase IS200-family protein YP_001492906.1 50123 R 293614 CDS YP_001492907.1 157825187 5645315 51227..51445 1 NC_009881.1 COG1943 Transposase and inactivated derivatives; transposase IS200-family protein 51445 5645315 A1C_00330 Rickettsia akari str. Hartford transposase IS200-family protein YP_001492907.1 51227 D 293614 CDS YP_001492908.1 157825188 5645316 complement(51835..51969) 1 NC_009881.1 30S ribosomal protein S6 51969 rpsF 5645316 rpsF Rickettsia akari str. Hartford 30S ribosomal protein S6 YP_001492908.1 51835 R 293614 CDS YP_001492909.1 157825189 5645317 52263..52691 1 NC_009881.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 52691 rpsF 5645317 rpsF Rickettsia akari str. Hartford 30S ribosomal protein S6 YP_001492909.1 52263 D 293614 CDS YP_001492910.1 157825190 5645318 52716..53003 1 NC_009881.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 53003 rpsR 5645318 rpsR Rickettsia akari str. Hartford 30S ribosomal protein S18 YP_001492910.1 52716 D 293614 CDS YP_001492911.1 157825191 5644920 53015..53530 1 NC_009881.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 53530 rplI 5644920 rplI Rickettsia akari str. Hartford 50S ribosomal protein L9 YP_001492911.1 53015 D 293614 CDS YP_001492912.1 157825192 5644921 53771..55063 1 NC_009881.1 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; tRNA(Ile)-lysidine synthetase TilS 55063 5644921 A1C_00355 Rickettsia akari str. Hartford tRNA(Ile)-lysidine synthetase TilS YP_001492912.1 53771 D 293614 CDS YP_001492913.1 157825193 5644922 55116..57029 1 NC_009881.1 COG0465 ATP-dependent Zn proteases; cell division protein ftsH 57029 5644922 A1C_00360 Rickettsia akari str. Hartford cell division protein ftsH YP_001492913.1 55116 D 293614 CDS YP_001492914.1 157825194 5644923 57126..57407 1 NC_009881.1 COG0270 Site-specific DNA methylase; site-specific DNA methylase 57407 5644923 A1C_00365 Rickettsia akari str. Hartford site-specific DNA methylase YP_001492914.1 57126 D 293614 CDS YP_001492915.1 157825195 5644924 57985..58125 1 NC_009881.1 succinate dehydrogenase iron-sulfur subunit 58125 sdhB 5644924 sdhB Rickettsia akari str. Hartford succinate dehydrogenase iron-sulfur subunit YP_001492915.1 57985 D 293614 CDS YP_001492916.1 157825196 5644925 58505..58708 1 NC_009881.1 hypothetical protein 58708 5644925 A1C_00375 Rickettsia akari str. Hartford hypothetical protein YP_001492916.1 58505 D 293614 CDS YP_001492917.1 157825197 5644926 58740..59525 1 NC_009881.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 59525 sdhB 5644926 sdhB Rickettsia akari str. Hartford succinate dehydrogenase iron-sulfur subunit YP_001492917.1 58740 D 293614 CDS YP_001492918.1 157825198 5645096 59601..59813 1 NC_009881.1 COG3755 Uncharacterized protein conserved in bacteria; hypothetical protein 59813 5645096 A1C_00385 Rickettsia akari str. Hartford hypothetical protein YP_001492918.1 59601 D 293614 CDS YP_001492919.1 157825199 5645097 complement(59948..61072) 1 NC_009881.1 COG1565 Uncharacterized conserved protein; hypothetical protein 61072 5645097 A1C_00390 Rickettsia akari str. Hartford hypothetical protein YP_001492919.1 59948 R 293614 CDS YP_001492920.1 157825200 5645098 complement(61051..61830) 1 NC_009881.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 61830 5645098 A1C_00395 Rickettsia akari str. Hartford prolipoprotein diacylglyceryl transferase YP_001492920.1 61051 R 293614 CDS YP_001492921.1 157825201 5645099 62087..63241 1 NC_009881.1 COG0668 Small-conductance mechanosensitive channel; hypothetical protein 63241 5645099 A1C_00400 Rickettsia akari str. Hartford hypothetical protein YP_001492921.1 62087 D 293614 CDS YP_001492922.1 157825202 5645100 63370..65052 1 NC_009881.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 65052 5645100 A1C_00405 Rickettsia akari str. Hartford putative inner membrane protein translocase component YidC YP_001492922.1 63370 D 293614 CDS YP_001492923.1 157825203 5645101 65052..65597 1 NC_009881.1 COG0558 Phosphatidylglycerophosphate synthase; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 65597 5645101 A1C_00410 Rickettsia akari str. Hartford CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_001492923.1 65052 D 293614 CDS YP_001492924.1 157825204 5645102 65612..66172 1 NC_009881.1 hypothetical protein 66172 5645102 A1C_00415 Rickettsia akari str. Hartford hypothetical protein YP_001492924.1 65612 D 293614 CDS YP_001492925.1 157825205 5644992 complement(66476..66859) 1 NC_009881.1 hypothetical protein 66859 5644992 A1C_00420 Rickettsia akari str. Hartford hypothetical protein YP_001492925.1 66476 R 293614 CDS YP_001492926.1 157825206 5644993 67369..67653 1 NC_009881.1 COG0500 SAM-dependent methyltransferases; tellurite resistance protein-like protein 67653 5644993 A1C_00425 Rickettsia akari str. Hartford tellurite resistance protein-like protein YP_001492926.1 67369 D 293614 CDS YP_001492927.1 157825207 5644994 67847..67933 1 NC_009881.1 hypothetical protein 67933 5644994 A1C_00430 Rickettsia akari str. Hartford hypothetical protein YP_001492927.1 67847 D 293614 CDS YP_001492928.1 157825208 5644995 complement(68372..68674) 1 NC_009881.1 COG0242 N-formylmethionyl-tRNA deformylase; polypeptide deformylase 68674 5644995 A1C_00435 Rickettsia akari str. Hartford polypeptide deformylase YP_001492928.1 68372 R 293614 CDS YP_001492929.1 157825209 5644996 69227..70723 1 NC_009881.1 COG3202 ATP/ADP translocase; ADP,ATP carrier protein 70723 5644996 A1C_00440 Rickettsia akari str. Hartford ADP,ATP carrier protein YP_001492929.1 69227 D 293614 CDS YP_001492930.1 157825210 5644997 70807..72096 1 NC_009881.1 COG2271 Sugar phosphate permease; sugar phosphate permease 72096 5644997 A1C_00445 Rickettsia akari str. Hartford sugar phosphate permease YP_001492930.1 70807 D 293614 CDS YP_001492931.1 157825211 5644998 72124..72546 1 NC_009881.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 72546 ndk 5644998 ndk Rickettsia akari str. Hartford nucleoside diphosphate kinase YP_001492931.1 72124 D 293614 CDS YP_001492932.1 157825212 5645365 72550..74418 1 NC_009881.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 74418 5645365 A1C_00455 Rickettsia akari str. Hartford tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_001492932.1 72550 D 293614 CDS YP_001492933.1 157825213 5645366 74402..74977 1 NC_009881.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 74977 gidB 5645366 gidB Rickettsia akari str. Hartford 16S rRNA methyltransferase GidB YP_001492933.1 74402 D 293614 CDS YP_001492934.1 157825214 5645367 74974..75741 1 NC_009881.1 COG1192 ATPases involved in chromosome partitioning; soj protein 75741 5645367 A1C_00465 Rickettsia akari str. Hartford soj protein YP_001492934.1 74974 D 293614 CDS YP_001492935.1 157825215 5645368 75728..76588 1 NC_009881.1 COG1475 Predicted transcriptional regulators; stage 0 sporulation protein J 76588 5645368 A1C_00470 Rickettsia akari str. Hartford stage 0 sporulation protein J YP_001492935.1 75728 D 293614 CDS YP_001492936.1 157825216 5645369 76776..78443 1 NC_009881.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 78443 5645369 A1C_00475 Rickettsia akari str. Hartford putative ABC transporter ATP-binding protein YP_001492936.1 76776 D 293614 CDS YP_001492937.1 157825217 5645370 78446..78763 1 NC_009881.1 hypothetical protein 78763 5645370 A1C_00480 Rickettsia akari str. Hartford hypothetical protein YP_001492937.1 78446 D 293614 CDS YP_001492938.1 157825218 5645371 78798..79622 1 NC_009881.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 79622 5645371 A1C_00485 Rickettsia akari str. Hartford 2-dehydro-3-deoxyphosphooctonate aldolase YP_001492938.1 78798 D 293614 CDS YP_001492939.1 157825219 5644706 80008..80202 1 NC_009881.1 hypothetical protein 80202 5644706 A1C_00490 Rickettsia akari str. Hartford hypothetical protein YP_001492939.1 80008 D 293614 CDS YP_001492940.1 157825220 5644707 complement(80966..81298) 1 NC_009881.1 COG0316 Uncharacterized conserved protein; Iron-sulfur cluster assembly accessory protein 81298 5644707 A1C_00495 Rickettsia akari str. Hartford Iron-sulfur cluster assembly accessory protein YP_001492940.1 80966 R 293614 CDS YP_001492941.1 157825221 5644708 81556..82731 1 NC_009881.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 82731 5644708 A1C_00500 Rickettsia akari str. Hartford deoxyguanosinetriphosphate triphosphohydrolase-like protein YP_001492941.1 81556 D 293614 CDS YP_001492942.1 157825222 5644709 82718..84448 1 NC_009881.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 84448 argS 5644709 argS Rickettsia akari str. Hartford arginyl-tRNA synthetase YP_001492942.1 82718 D 293614 CDS YP_001492943.1 157825223 5644710 84595..85269 1 NC_009881.1 hypothetical protein 85269 5644710 A1C_00510 Rickettsia akari str. Hartford hypothetical protein YP_001492943.1 84595 D 293614 CDS YP_001492944.1 157825224 5644711 85287..85445 1 NC_009881.1 hypothetical protein 85445 5644711 A1C_00515 Rickettsia akari str. Hartford hypothetical protein YP_001492944.1 85287 D 293614 CDS YP_001492945.1 157825225 5644712 85586..87799 1 NC_009881.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 87799 5644712 A1C_00520 Rickettsia akari str. Hartford DNA topoisomerase IV subunit A YP_001492945.1 85586 D 293614 CDS YP_001492946.1 157825226 5645665 complement(87929..88105) 1 NC_009881.1 hypothetical protein 88105 5645665 A1C_00525 Rickettsia akari str. Hartford hypothetical protein YP_001492946.1 87929 R 293614 CDS YP_001492947.1 157825227 5645666 complement(88459..88617) 1 NC_009881.1 hypothetical protein 88617 5645666 A1C_00530 Rickettsia akari str. Hartford hypothetical protein YP_001492947.1 88459 R 293614 CDS YP_001492948.1 157825228 5645667 complement(89150..90469) 1 NC_009881.1 COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases; putative surface antigen 90469 5645667 A1C_00535 Rickettsia akari str. Hartford putative surface antigen YP_001492948.1 89150 R 293614 CDS YP_001492949.1 157825229 5645668 90754..91320 1 NC_009881.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 91320 dcd 5645668 dcd Rickettsia akari str. Hartford deoxycytidine triphosphate deaminase YP_001492949.1 90754 D 293614 CDS YP_001492950.1 157825230 5645669 91529..91987 1 NC_009881.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 91987 5645669 A1C_00545 Rickettsia akari str. Hartford preprotein translocase subunit SecB YP_001492950.1 91529 D 293614 CDS YP_001492951.1 157825231 5645670 92212..92925 1 NC_009881.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; transcriptional activator protein CzcR 92925 5645670 A1C_00550 Rickettsia akari str. Hartford transcriptional activator protein CzcR YP_001492951.1 92212 D 293614 CDS YP_001492952.1 157825232 5645671 92929..93750 1 NC_009881.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 93750 queF 5645671 queF Rickettsia akari str. Hartford 7-cyano-7-deazaguanine reductase YP_001492952.1 92929 D 293614 CDS YP_001492953.1 157825233 5645845 complement(94039..94644) 1 NC_009881.1 COG3820 Uncharacterized protein conserved in bacteria; hypothetical protein 94644 5645845 A1C_00560 Rickettsia akari str. Hartford hypothetical protein YP_001492953.1 94039 R 293614 CDS YP_001492954.1 157825234 5645846 complement(94698..96095) 1 NC_009881.1 COG1282 NAD/NADP transhydrogenase beta subunit; NAD(p) transhydrogenase subunit beta 96095 5645846 A1C_00565 Rickettsia akari str. Hartford NAD(p) transhydrogenase subunit beta YP_001492954.1 94698 R 293614 CDS YP_001492955.1 157825235 5645847 complement(96288..97022) 1 NC_009881.1 COG3047 Outer membrane protein W; OmpW family outer-membrane protein 97022 5645847 A1C_00570 Rickettsia akari str. Hartford OmpW family outer-membrane protein YP_001492955.1 96288 R 293614 CDS YP_001492956.1 157825236 5645848 97178..98062 1 NC_009881.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; S-adenosylmethionine transporter 98062 5645848 A1C_00575 Rickettsia akari str. Hartford S-adenosylmethionine transporter YP_001492956.1 97178 D 293614 CDS YP_001492957.1 157825237 5645849 98049..99305 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; proline/betaine transporter 99305 5645849 A1C_00580 Rickettsia akari str. Hartford proline/betaine transporter YP_001492957.1 98049 D 293614 CDS YP_001492958.1 157825238 5645850 complement(98213..98392) 1 NC_009881.1 preprotein translocase subunit SecG 98392 secG 5645850 secG Rickettsia akari str. Hartford preprotein translocase subunit SecG YP_001492958.1 98213 R 293614 CDS YP_001492959.1 157825239 5645851 99721..99795 1 NC_009881.1 hypothetical protein 99795 5645851 A1C_00590 Rickettsia akari str. Hartford hypothetical protein YP_001492959.1 99721 D 293614 CDS YP_001492960.1 157825240 5645320 99977..100279 1 NC_009881.1 preprotein translocase subunit SecG 100279 secG 5645320 secG Rickettsia akari str. Hartford preprotein translocase subunit SecG YP_001492960.1 99977 D 293614 CDS YP_001492961.1 157825241 5645321 100596..101300 1 NC_009881.1 COG1738 Uncharacterized conserved protein; hypothetical protein 101300 5645321 A1C_00600 Rickettsia akari str. Hartford hypothetical protein YP_001492961.1 100596 D 293614 CDS YP_001492962.1 157825242 5645322 complement(101331..106664) 1 NC_009881.1 COG1196 Chromosome segregation ATPases; hypothetical protein 106664 5645322 A1C_00605 Rickettsia akari str. Hartford hypothetical protein YP_001492962.1 101331 R 293614 CDS YP_001492963.1 157825243 5645323 complement(107146..112578) 1 NC_009881.1 hypothetical protein 112578 5645323 A1C_00610 Rickettsia akari str. Hartford hypothetical protein YP_001492963.1 107146 R 293614 CDS YP_001492964.1 157825244 5645324 112799..114178 1 NC_009881.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 114178 cysS 5645324 cysS Rickettsia akari str. Hartford cysteinyl-tRNA synthetase YP_001492964.1 112799 D 293614 CDS YP_001492965.1 157825245 5645687 114515..115402 1 NC_009881.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 115402 rpsB 5645687 rpsB Rickettsia akari str. Hartford 30S ribosomal protein S2 YP_001492965.1 114515 D 293614 CDS YP_001492966.1 157825246 5645688 115646..116575 1 NC_009881.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 116575 tsf 5645688 tsf Rickettsia akari str. Hartford elongation factor Ts YP_001492966.1 115646 D 293614 CDS YP_001492967.1 157825247 5645689 complement(117140..117250) 1 NC_009881.1 hypothetical protein 117250 5645689 A1C_00630 Rickettsia akari str. Hartford hypothetical protein YP_001492967.1 117140 R 293614 CDS YP_001492968.1 157825248 5645690 complement(117658..117897) 1 NC_009881.1 hypothetical protein 117897 5645690 A1C_00635 Rickettsia akari str. Hartford hypothetical protein YP_001492968.1 117658 R 293614 CDS YP_001492969.1 157825249 5645691 complement(117994..119250) 1 NC_009881.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 119250 5645691 A1C_00640 Rickettsia akari str. Hartford 3-deoxy-D-manno-octulosonic-acid transferase YP_001492969.1 117994 R 293614 CDS YP_001492970.1 157825250 5645692 complement(119247..119903) 1 NC_009881.1 COG2121 Uncharacterized protein conserved in bacteria; hypothetical protein 119903 5645692 A1C_00645 Rickettsia akari str. Hartford hypothetical protein YP_001492970.1 119247 R 293614 CDS YP_001492971.1 157825251 5645693 complement(120021..121220) 1 NC_009881.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 121220 5645693 A1C_00650 Rickettsia akari str. Hartford aspartate aminotransferase YP_001492971.1 120021 R 293614 CDS YP_001492972.1 157825252 5645284 121439..122443 1 NC_009881.1 COG0457 FOG: TPR repeat; hypothetical protein 122443 5645284 A1C_00655 Rickettsia akari str. Hartford hypothetical protein YP_001492972.1 121439 D 293614 CDS YP_001492973.1 157825253 5645285 122448..123203 1 NC_009881.1 COG2853 Surface lipoprotein; VacJ lipoprotein precursor 123203 5645285 A1C_00660 Rickettsia akari str. Hartford VacJ lipoprotein precursor YP_001492973.1 122448 D 293614 CDS YP_001492974.1 157825254 5645286 123223..123822 1 NC_009881.1 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component; hypothetical protein 123822 5645286 A1C_00665 Rickettsia akari str. Hartford hypothetical protein YP_001492974.1 123223 D 293614 CDS YP_001492975.1 157825255 5645287 complement(124078..124305) 1 NC_009881.1 COG1943 Transposase and inactivated derivatives; transposase IS200-family protein 124305 5645287 A1C_00670 Rickettsia akari str. Hartford transposase IS200-family protein YP_001492975.1 124078 R 293614 CDS YP_001492976.1 157825256 5645288 124829..124984 1 NC_009881.1 hypothetical protein 124984 5645288 A1C_00675 Rickettsia akari str. Hartford hypothetical protein YP_001492976.1 124829 D 293614 CDS YP_001492977.1 157825257 5645289 124962..125144 1 NC_009881.1 hypothetical protein 125144 5645289 A1C_00680 Rickettsia akari str. Hartford hypothetical protein YP_001492977.1 124962 D 293614 CDS YP_001492978.1 157825258 5645290 complement(125514..125651) 1 NC_009881.1 hypothetical protein 125651 5645290 A1C_00685 Rickettsia akari str. Hartford hypothetical protein YP_001492978.1 125514 R 293614 CDS YP_001492979.1 157825259 5645473 complement(125999..126250) 1 NC_009881.1 alpha/beta hydrolase superfamily esterase 126250 5645473 A1C_00690 Rickettsia akari str. Hartford alpha/beta hydrolase superfamily esterase YP_001492979.1 125999 R 293614 CDS YP_001492980.1 157825260 5645474 complement(126229..126399) 1 NC_009881.1 alpha/beta hydrolase superfamily esterase 126399 5645474 A1C_00695 Rickettsia akari str. Hartford alpha/beta hydrolase superfamily esterase YP_001492980.1 126229 R 293614 CDS YP_001492981.1 157825261 5645475 complement(126589..127080) 1 NC_009881.1 hypothetical protein 127080 5645475 A1C_00700 Rickettsia akari str. Hartford hypothetical protein YP_001492981.1 126589 R 293614 CDS YP_001492982.1 157825262 5645476 complement(127170..128330) 1 NC_009881.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 128330 5645476 A1C_00705 Rickettsia akari str. Hartford putative DNA-binding/iron metalloprotein/AP endonuclease YP_001492982.1 127170 R 293614 CDS YP_001492983.1 157825263 5645477 complement(128643..129836) 1 NC_009881.1 COG1398 Fatty-acid desaturase; Acyl-CoA desaturase 1 129836 5645477 A1C_00710 Rickettsia akari str. Hartford Acyl-CoA desaturase 1 YP_001492983.1 128643 R 293614 CDS YP_001492984.1 157825264 5645478 130177..130353 1 NC_009881.1 COG0462 Phosphoribosylpyrophosphate synthetase; ribose-phosphate pyrophosphokinase 130353 5645478 A1C_00715 Rickettsia akari str. Hartford ribose-phosphate pyrophosphokinase YP_001492984.1 130177 D 293614 CDS YP_001492985.1 157825265 5645479 130548..130682 1 NC_009881.1 COG0462 Phosphoribosylpyrophosphate synthetase; alanine racemase 130682 alr 5645479 alr Rickettsia akari str. Hartford alanine racemase YP_001492985.1 130548 D 293614 CDS YP_001492986.1 157825266 5644890 130691..130849 1 NC_009881.1 hypothetical protein 130849 5644890 A1C_00725 Rickettsia akari str. Hartford hypothetical protein YP_001492986.1 130691 D 293614 CDS YP_001492987.1 157825267 5644891 130846..131913 1 NC_009881.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 131913 alr 5644891 alr Rickettsia akari str. Hartford alanine racemase YP_001492987.1 130846 D 293614 CDS YP_001492988.1 157825268 5644892 132123..132902 1 NC_009881.1 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component; ABC transporter permease 132902 5644892 A1C_00735 Rickettsia akari str. Hartford ABC transporter permease YP_001492988.1 132123 D 293614 CDS YP_001492989.1 157825269 5644893 133135..133890 1 NC_009881.1 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component; ribonucleotide ABC transporter ATP-binding protein 133890 5644893 A1C_00740 Rickettsia akari str. Hartford ribonucleotide ABC transporter ATP-binding protein YP_001492989.1 133135 D 293614 CDS YP_001492990.1 157825270 5644894 133892..134140 1 NC_009881.1 hypothetical protein 134140 5644894 A1C_00745 Rickettsia akari str. Hartford hypothetical protein YP_001492990.1 133892 D 293614 CDS YP_001492991.1 157825271 5644895 134219..134512 1 NC_009881.1 required for 70S ribosome assembly; 50S ribosomal protein L28 134512 rpmB 5644895 rpmB Rickettsia akari str. Hartford 50S ribosomal protein L28 YP_001492991.1 134219 D 293614 CDS YP_001492992.1 157825272 5644896 134509..134745 1 NC_009881.1 RpmE; RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 134745 5644896 A1C_00755 Rickettsia akari str. Hartford 50S ribosomal protein L31 YP_001492992.1 134509 D 293614 CDS YP_001492993.1 157825273 5645784 135384..136022 1 NC_009881.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 136022 engB 5645784 engB Rickettsia akari str. Hartford ribosome biogenesis GTP-binding protein YsxC YP_001492993.1 135384 D 293614 CDS YP_001492994.1 157825274 5645785 136910..137197 1 NC_009881.1 COG3702 Type IV secretory pathway, VirB3 components; type IV secretion system protein VirB3 137197 5645785 A1C_00780 Rickettsia akari str. Hartford type IV secretion system protein VirB3 YP_001492994.1 136910 D 293614 CDS YP_001492995.1 157825275 5645786 137496..139913 1 NC_009881.1 COG3451 Type IV secretory pathway, VirB4 components; type IV secretion system ATPase VirB4 139913 5645786 A1C_00785 Rickettsia akari str. Hartford type IV secretion system ATPase VirB4 YP_001492995.1 137496 D 293614 CDS YP_001492996.1 157825276 5645787 140088..143114 1 NC_009881.1 COG3704 Type IV secretory pathway, VirB6 components; TrbL/VirB6 plasmid conjugative transfer protein 143114 5645787 A1C_00790 Rickettsia akari str. Hartford TrbL/VirB6 plasmid conjugative transfer protein YP_001492996.1 140088 D 293614 CDS YP_001492997.1 157825277 5645788 143101..145119 1 NC_009881.1 COG3704 Type IV secretory pathway, VirB6 components; TrbL/VirB6 plasmid conjugative transfer protein 145119 5645788 A1C_00795 Rickettsia akari str. Hartford TrbL/VirB6 plasmid conjugative transfer protein YP_001492997.1 143101 D 293614 CDS YP_001492998.1 157825278 5645497 145126..148056 1 NC_009881.1 COG3704 Type IV secretory pathway, VirB6 components; hypothetical protein 148056 5645497 A1C_00800 Rickettsia akari str. Hartford hypothetical protein YP_001492998.1 145126 D 293614 CDS YP_001492999.1 157825279 5645498 148265..150895 1 NC_009881.1 COG3704 Type IV secretory pathway, VirB6 components; TrbL/VirB6 plasmid conjugative transfer protein 150895 5645498 A1C_00805 Rickettsia akari str. Hartford TrbL/VirB6 plasmid conjugative transfer protein YP_001492999.1 148265 D 293614 CDS YP_001493000.1 157825280 5645499 151083..154547 1 NC_009881.1 COG3704 Type IV secretory pathway, VirB6 components; TrbL/VirB6 plasmid conjugative transfer protein 154547 5645499 A1C_00810 Rickettsia akari str. Hartford TrbL/VirB6 plasmid conjugative transfer protein YP_001493000.1 151083 D 293614 CDS YP_001493001.1 157825281 5645500 154665..154781 1 NC_009881.1 antitoxin of toxin-antitoxin system VapB 154781 5645500 A1C_00815 Rickettsia akari str. Hartford antitoxin of toxin-antitoxin system VapB YP_001493001.1 154665 D 293614 CDS YP_001493002.1 157825282 5645501 154859..155110 1 NC_009881.1 COG1487 Predicted nucleic acid-binding protein, contains PIN domain; toxin of toxin-antitoxin system 155110 5645501 A1C_00820 Rickettsia akari str. Hartford toxin of toxin-antitoxin system YP_001493002.1 154859 D 293614 CDS YP_001493003.1 157825283 5645502 155369..156418 1 NC_009881.1 catalyzes the formation of acetyl phosphate from acetyl-CoA and phosphate; can also act with other short-chain acyl-CoAs; phosphate acetyltransferase 156418 5645502 A1C_00825 Rickettsia akari str. Hartford phosphate acetyltransferase YP_001493003.1 155369 D 293614 CDS YP_001493004.1 157825284 5645503 156420..157577 1 NC_009881.1 COG0282 Acetate kinase; acetate kinase 157577 5645503 A1C_00830 Rickettsia akari str. Hartford acetate kinase YP_001493004.1 156420 D 293614 CDS YP_001493005.1 157825285 5645089 157903..158067 1 NC_009881.1 tRNA (guanine-N(1)-)-methyltransferase 158067 trmD 5645089 trmD Rickettsia akari str. Hartford tRNA (guanine-N(1)-)-methyltransferase YP_001493005.1 157903 D 293614 CDS YP_001493006.1 157825286 5645090 158144..158848 1 NC_009881.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 158848 trmD 5645090 trmD Rickettsia akari str. Hartford tRNA (guanine-N(1)-)-methyltransferase YP_001493006.1 158144 D 293614 CDS YP_001493007.1 157825287 5645091 158864..159280 1 NC_009881.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 159280 rplS 5645091 rplS Rickettsia akari str. Hartford 50S ribosomal protein L19 YP_001493007.1 158864 D 293614 CDS YP_001493008.1 157825288 5645092 complement(159658..159894) 1 NC_009881.1 COG3750 Uncharacterized protein conserved in bacteria; hypothetical protein 159894 5645092 A1C_00850 Rickettsia akari str. Hartford hypothetical protein YP_001493008.1 159658 R 293614 CDS YP_001493009.1 157825289 5645093 160092..161018 1 NC_009881.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 161018 secF 5645093 secF Rickettsia akari str. Hartford preprotein translocase subunit SecF YP_001493009.1 160092 D 293614 CDS YP_001493010.1 157825290 5645094 161250..162521 1 NC_009881.1 part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 162521 5645094 A1C_00860 Rickettsia akari str. Hartford NADH dehydrogenase I subunit F YP_001493010.1 161250 D 293614 CDS YP_001493011.1 157825291 5645095 162646..163446 1 NC_009881.1 COG0681 Signal peptidase I; Signal peptidase I 163446 5645095 A1C_00865 Rickettsia akari str. Hartford Signal peptidase I YP_001493011.1 162646 D 293614 CDS YP_001493012.1 157825292 5645325 163446..164129 1 NC_009881.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 164129 rnc 5645325 rnc Rickettsia akari str. Hartford ribonuclease III YP_001493012.1 163446 D 293614 CDS YP_001493013.1 157825293 5645326 164122..165003 1 NC_009881.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 165003 era 5645326 era Rickettsia akari str. Hartford GTP-binding protein Era YP_001493013.1 164122 D 293614 CDS YP_001493014.1 157825294 5645327 165101..165574 1 NC_009881.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 165574 ruvC 5645327 ruvC Rickettsia akari str. Hartford Holliday junction resolvase YP_001493014.1 165101 D 293614 CDS YP_001493015.1 157825295 5645328 165571..166266 1 NC_009881.1 COG0565 rRNA methylase; tRNA/rRNA methyltransferase 166266 5645328 A1C_00885 Rickettsia akari str. Hartford tRNA/rRNA methyltransferase YP_001493015.1 165571 D 293614 CDS YP_001493016.1 157825296 5645329 complement(166641..166775) 1 NC_009881.1 nucleotidyltransferase 166775 5645329 A1C_00890 Rickettsia akari str. Hartford nucleotidyltransferase YP_001493016.1 166641 R 293614 CDS YP_001493017.1 157825297 5645330 complement(166951..168132) 1 NC_009881.1 COG3660 Predicted nucleoside-diphosphate-sugar epimerase; hypothetical protein 168132 5645330 A1C_00895 Rickettsia akari str. Hartford hypothetical protein YP_001493017.1 166951 R 293614 CDS YP_001493018.1 157825298 5645331 complement(168129..169091) 1 NC_009881.1 COG0489 ATPases involved in chromosome partitioning; Mrp protein 169091 5645331 A1C_00900 Rickettsia akari str. Hartford Mrp protein YP_001493018.1 168129 R 293614 CDS YP_001493019.1 157825299 5645172 169191..170228 1 NC_009881.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs; protease activity modulator HflK 170228 5645172 A1C_00905 Rickettsia akari str. Hartford protease activity modulator HflK YP_001493019.1 169191 D 293614 CDS YP_001493020.1 157825300 5645173 170246..170395 1 NC_009881.1 hypothetical protein 170395 5645173 A1C_00910 Rickettsia akari str. Hartford hypothetical protein YP_001493020.1 170246 D 293614 CDS YP_001493021.1 157825301 5645174 170371..171231 1 NC_009881.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs; membrane protease subunit stomatin/prohibitin-like protein 171231 5645174 A1C_00915 Rickettsia akari str. Hartford membrane protease subunit stomatin/prohibitin-like protein YP_001493021.1 170371 D 293614 CDS YP_001493022.1 157825302 5645175 171236..172774 1 NC_009881.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; serine protease 172774 5645175 A1C_00920 Rickettsia akari str. Hartford serine protease YP_001493022.1 171236 D 293614 CDS YP_001493023.1 157825303 5645176 172853..173596 1 NC_009881.1 COG1054 Predicted sulfurtransferase; hypothetical protein 173596 5645176 A1C_00925 Rickettsia akari str. Hartford hypothetical protein YP_001493023.1 172853 D 293614 CDS YP_001493024.1 157825304 5645177 173782..174156 1 NC_009881.1 COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit; succinate dehydrogenase cytochrome b-556 subunit 174156 5645177 A1C_00930 Rickettsia akari str. Hartford succinate dehydrogenase cytochrome b-556 subunit YP_001493024.1 173782 D 293614 CDS YP_001493025.1 157825305 5645178 174317..174409 1 NC_009881.1 hypothetical protein 174409 5645178 A1C_00935 Rickettsia akari str. Hartford hypothetical protein YP_001493025.1 174317 D 293614 CDS YP_001493026.1 157825306 5645760 174409..174786 1 NC_009881.1 COG2142 Succinate dehydrogenase, hydrophobic anchor subunit; succinate dehydrogenase hydrophobic membrane anchor protein 174786 5645760 A1C_00940 Rickettsia akari str. Hartford succinate dehydrogenase hydrophobic membrane anchor protein YP_001493026.1 174409 D 293614 CDS YP_001493027.1 157825307 5645761 174783..174938 1 NC_009881.1 hypothetical protein 174938 5645761 A1C_00945 Rickettsia akari str. Hartford hypothetical protein YP_001493027.1 174783 D 293614 CDS YP_001493028.1 157825308 5645762 175024..175290 1 NC_009881.1 toxin of toxin-antitoxin (TA) system ParE 175290 5645762 A1C_00950 Rickettsia akari str. Hartford toxin of toxin-antitoxin (TA) system ParE YP_001493028.1 175024 D 293614 CDS YP_001493029.1 157825309 5645763 175325..177115 1 NC_009881.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 177115 sdhA 5645763 sdhA Rickettsia akari str. Hartford succinate dehydrogenase flavoprotein subunit YP_001493029.1 175325 D 293614 CDS YP_001493030.1 157825310 5645764 177373..178029 1 NC_009881.1 COG0765 ABC-type amino acid transport system, permease component; amino acid ABC transporter permease 178029 5645764 A1C_00960 Rickettsia akari str. Hartford amino acid ABC transporter permease YP_001493030.1 177373 D 293614 CDS YP_001493031.1 157825311 5645765 178187..178576 1 NC_009881.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 178576 rpsL 5645765 rpsL Rickettsia akari str. Hartford 30S ribosomal protein S12 YP_001493031.1 178187 D 293614 CDS YP_001493032.1 157825312 5645766 178603..179085 1 NC_009881.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 179085 5645766 A1C_00970 Rickettsia akari str. Hartford 30S ribosomal protein S7 YP_001493032.1 178603 D 293614 CDS YP_001493033.1 157825313 5645702 179099..181198 1 NC_009881.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 181198 5645702 A1C_00975 Rickettsia akari str. Hartford elongation factor G YP_001493033.1 179099 D 293614 CDS YP_001493034.1 157825314 5645704 181572..181778 1 NC_009881.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 181778 secE 5645704 secE Rickettsia akari str. Hartford preprotein translocase subunit SecE YP_001493034.1 181572 D 293614 CDS YP_001493035.1 157825315 5645705 181789..182367 1 NC_009881.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 182367 nusG 5645705 nusG Rickettsia akari str. Hartford transcription antitermination protein NusG YP_001493035.1 181789 D 293614 CDS YP_001493036.1 157825316 5645706 182582..183019 1 NC_009881.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 183019 rplK 5645706 rplK Rickettsia akari str. Hartford 50S ribosomal protein L11 YP_001493036.1 182582 D 293614 CDS YP_001493037.1 157825317 5645707 183025..183744 1 NC_009881.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 183744 rplA 5645707 rplA Rickettsia akari str. Hartford 50S ribosomal protein L1 YP_001493037.1 183025 D 293614 CDS YP_001493038.1 157825318 5644713 183846..184355 1 NC_009881.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 184355 rplJ 5644713 rplJ Rickettsia akari str. Hartford 50S ribosomal protein L10 YP_001493038.1 183846 D 293614 CDS YP_001493039.1 157825319 5644714 184545..184919 1 NC_009881.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 184919 rplL 5644714 rplL Rickettsia akari str. Hartford 50S ribosomal protein L7/L12 YP_001493039.1 184545 D 293614 CDS YP_001493040.1 157825320 5644715 185804..189925 1 NC_009881.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 189925 rpoB 5644715 rpoB Rickettsia akari str. Hartford DNA-directed RNA polymerase subunit beta YP_001493040.1 185804 D 293614 CDS YP_001493041.1 157825321 5644716 190244..194362 1 NC_009881.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 194362 5644716 A1C_01015 Rickettsia akari str. Hartford DNA-directed RNA polymerase subunit beta' YP_001493041.1 190244 D 293614 CDS YP_001493042.1 157825322 5644717 complement(194789..195817) 1 NC_009881.1 hypothetical protein 195817 5644717 A1C_01020 Rickettsia akari str. Hartford hypothetical protein YP_001493042.1 194789 R 293614 CDS YP_001493043.1 157825323 5644718 196090..197574 1 NC_009881.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 197574 5644718 A1C_01025 Rickettsia akari str. Hartford leucyl aminopeptidase YP_001493043.1 196090 D 293614 CDS YP_001493044.1 157825324 5644719 197755..198555 1 NC_009881.1 COG1192 ATPases involved in chromosome partitioning; chromosome partitioning protein 198555 5644719 A1C_01030 Rickettsia akari str. Hartford chromosome partitioning protein YP_001493044.1 197755 D 293614 CDS YP_001493045.1 157825325 5645716 198641..199075 1 NC_009881.1 hypothetical protein 199075 5645716 A1C_01035 Rickettsia akari str. Hartford hypothetical protein YP_001493045.1 198641 D 293614 CDS YP_001493046.1 157825326 5645717 199154..200962 1 NC_009881.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 200962 aspS 5645717 aspS Rickettsia akari str. Hartford aspartyl-tRNA synthetase YP_001493046.1 199154 D 293614 CDS YP_001493047.1 157825327 5645718 complement(201228..203342) 1 NC_009881.1 hypothetical protein 203342 5645718 A1C_01045 Rickettsia akari str. Hartford hypothetical protein YP_001493047.1 201228 R 293614 CDS YP_001493048.1 157825328 5645719 complement(203364..204074) 1 NC_009881.1 COG0670 Integral membrane protein, interacts with FtsH; integral membrane protein 204074 5645719 A1C_01050 Rickettsia akari str. Hartford integral membrane protein YP_001493048.1 203364 R 293614 CDS YP_001493049.1 157825329 5645720 complement(204120..204857) 1 NC_009881.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 204857 5645720 A1C_01055 Rickettsia akari str. Hartford dihydrodipicolinate reductase YP_001493049.1 204120 R 293614 CDS YP_001493050.1 157825330 5645721 complement(204876..205361) 1 NC_009881.1 COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family; hypothetical protein 205361 5645721 A1C_01060 Rickettsia akari str. Hartford hypothetical protein YP_001493050.1 204876 R 293614 CDS YP_001493051.1 157825331 5645722 complement(205346..206071) 1 NC_009881.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; amino acid ABC transporter substrate-binding protein 206071 5645722 A1C_01065 Rickettsia akari str. Hartford amino acid ABC transporter substrate-binding protein YP_001493051.1 205346 R 293614 CDS YP_001493052.1 157825332 5645053 complement(206276..207727) 1 NC_009881.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 207727 gatB 5645053 gatB Rickettsia akari str. Hartford aspartyl/glutamyl-tRNA amidotransferase subunit B YP_001493052.1 206276 R 293614 CDS YP_001493053.1 157825333 5645054 complement(207904..209382) 1 NC_009881.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 209382 gatA 5645054 gatA Rickettsia akari str. Hartford aspartyl/glutamyl-tRNA amidotransferase subunit A YP_001493053.1 207904 R 293614 CDS YP_001493054.1 157825334 5645055 complement(209385..209687) 1 NC_009881.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 209687 gatC 5645055 gatC Rickettsia akari str. Hartford aspartyl/glutamyl-tRNA amidotransferase subunit C YP_001493054.1 209385 R 293614 CDS YP_001493055.1 157825335 5645056 complement(209843..209989) 1 NC_009881.1 ribosome recycling factor 209989 frr 5645056 frr Rickettsia akari str. Hartford ribosome recycling factor YP_001493055.1 209843 R 293614 CDS YP_001493056.1 157825336 5645057 complement(210244..210804) 1 NC_009881.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 210804 frr 5645057 frr Rickettsia akari str. Hartford ribosome recycling factor YP_001493056.1 210244 R 293614 CDS YP_001493057.1 157825337 5645058 complement(211018..211755) 1 NC_009881.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 211755 pyrH 5645058 pyrH Rickettsia akari str. Hartford uridylate kinase YP_001493057.1 211018 R 293614 CDS YP_001493058.1 157825338 5645059 complement(211759..212076) 1 NC_009881.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit E 212076 5645059 A1C_01100 Rickettsia akari str. Hartford putative monovalent cation/H+ antiporter subunit E YP_001493058.1 211759 R 293614 CDS YP_001493059.1 157825339 5645138 complement(212060..213619) 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; multidrug resistance protein B 213619 5645138 A1C_01105 Rickettsia akari str. Hartford multidrug resistance protein B YP_001493059.1 212060 R 293614 CDS YP_001493060.1 157825340 5645139 213859..214062 1 NC_009881.1 COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes; hypothetical protein 214062 5645139 A1C_01110 Rickettsia akari str. Hartford hypothetical protein YP_001493060.1 213859 D 293614 CDS YP_001493061.1 157825341 5645140 215437..215658 1 NC_009881.1 COG1943 Transposase and inactivated derivatives; transposase IS200-family protein 215658 5645140 A1C_01115 Rickettsia akari str. Hartford transposase IS200-family protein YP_001493061.1 215437 D 293614 CDS YP_001493062.1 157825342 5645141 complement(215661..215813) 1 NC_009881.1 hypothetical protein 215813 5645141 A1C_01120 Rickettsia akari str. Hartford hypothetical protein YP_001493062.1 215661 R 293614 CDS YP_001493063.1 157825343 5645143 complement(216379..218673) 1 NC_009881.1 COG4775 Outer membrane protein/protective antigen OMA87; Outer membrane protein omp1 218673 5645143 A1C_01125 Rickettsia akari str. Hartford Outer membrane protein omp1 YP_001493063.1 216379 R 293614 CDS YP_001493064.1 157825344 5645194 complement(218955..220028) 1 NC_009881.1 COG0750 Predicted membrane-associated Zn-dependent proteases 1; membrane-associated zinc metalloprotease 220028 5645194 A1C_01130 Rickettsia akari str. Hartford membrane-associated zinc metalloprotease YP_001493064.1 218955 R 293614 CDS YP_001493065.1 157825345 5645195 220211..220681 1 NC_009881.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 220681 nusB 5645195 nusB Rickettsia akari str. Hartford transcription antitermination protein NusB YP_001493065.1 220211 D 293614 CDS YP_001493066.1 157825346 5645196 220678..221361 1 NC_009881.1 COG0293 23S rRNA methylase; ribosomal RNA large subunit methyltransferase J 221361 5645196 A1C_01140 Rickettsia akari str. Hartford ribosomal RNA large subunit methyltransferase J YP_001493066.1 220678 D 293614 CDS YP_001493067.1 157825347 5645197 complement(221399..222481) 1 NC_009881.1 hypothetical protein 222481 5645197 A1C_01145 Rickettsia akari str. Hartford hypothetical protein YP_001493067.1 221399 R 293614 CDS YP_001493068.1 157825348 5645198 222602..222763 1 NC_009881.1 hypothetical protein 222763 5645198 A1C_01150 Rickettsia akari str. Hartford hypothetical protein YP_001493068.1 222602 D 293614 CDS YP_001493069.1 157825349 5645199 222823..223554 1 NC_009881.1 hypothetical protein 223554 5645199 A1C_01155 Rickettsia akari str. Hartford hypothetical protein YP_001493069.1 222823 D 293614 CDS YP_001493070.1 157825350 5645200 complement(223613..224053) 1 NC_009881.1 COG2867 Oligoketide cyclase/lipid transport protein; hypothetical protein 224053 5645200 A1C_01160 Rickettsia akari str. Hartford hypothetical protein YP_001493070.1 223613 R 293614 CDS YP_001493071.1 157825351 5645615 complement(224058..224318) 1 NC_009881.1 multidrug ABC transporter ATPase and permease 224318 5645615 A1C_01165 Rickettsia akari str. Hartford multidrug ABC transporter ATPase and permease YP_001493071.1 224058 R 293614 CDS YP_001493072.1 157825352 5645616 224328..225092 1 NC_009881.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 225092 5645616 A1C_01170 Rickettsia akari str. Hartford 16S ribosomal RNA methyltransferase RsmE YP_001493072.1 224328 D 293614 CDS YP_001493073.1 157825353 5645617 complement(225716..225811) 1 NC_009881.1 hypothetical protein 225811 5645617 A1C_01180 Rickettsia akari str. Hartford hypothetical protein YP_001493073.1 225716 R 293614 CDS YP_001493074.1 157825354 5645618 227750..227869 1 NC_009881.1 hypothetical protein 227869 5645618 A1C_01205 Rickettsia akari str. Hartford hypothetical protein YP_001493074.1 227750 D 293614 CDS YP_001493075.1 157825355 5645619 complement(228276..228395) 1 NC_009881.1 hydrophobe/amphiphile efflux-1 HAE1 family protein 228395 5645619 A1C_01215 Rickettsia akari str. Hartford hydrophobe/amphiphile efflux-1 HAE1 family protein YP_001493075.1 228276 R 293614 CDS YP_001493076.1 157825356 5645620 228997..229329 1 NC_009881.1 COG0776 Bacterial nucleoid DNA-binding protein; DNA-binding protein HU 229329 5645620 A1C_01220 Rickettsia akari str. Hartford DNA-binding protein HU YP_001493076.1 228997 D 293614 CDS YP_001493077.1 157825357 5645621 229385..230263 1 NC_009881.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 230263 5645621 A1C_01225 Rickettsia akari str. Hartford DNA polymerase III subunit delta' YP_001493077.1 229385 D 293614 CDS YP_001493078.1 157825358 5644999 230546..231895 1 NC_009881.1 COG0541 Signal recognition particle GTPase; Signal recognition particle protein 231895 5644999 A1C_01230 Rickettsia akari str. Hartford Signal recognition particle protein YP_001493078.1 230546 D 293614 CDS YP_001493079.1 157825359 5645000 235282..236463 1 NC_009881.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 236463 5645000 A1C_01265 Rickettsia akari str. Hartford coproporphyrinogen III oxidase YP_001493079.1 235282 D 293614 CDS YP_001493080.1 157825360 5645001 complement(236630..236983) 1 NC_009881.1 hypothetical protein 236983 5645001 A1C_01270 Rickettsia akari str. Hartford hypothetical protein YP_001493080.1 236630 R 293614 CDS YP_001493081.1 157825361 5645002 complement(237617..237829) 1 NC_009881.1 hypothetical protein 237829 5645002 A1C_01275 Rickettsia akari str. Hartford hypothetical protein YP_001493081.1 237617 R 293614 CDS YP_001493082.1 157825362 5645003 complement(238225..239424) 1 NC_009881.1 COG1301 Na+/H+-dicarboxylate symporters; proton/sodium-glutamate symport protein 239424 5645003 A1C_01280 Rickettsia akari str. Hartford proton/sodium-glutamate symport protein YP_001493082.1 238225 R 293614 CDS YP_001493083.1 157825363 5645004 complement(239448..239762) 1 NC_009881.1 COG1324 Uncharacterized protein involved in tolerance to divalent cations; divalent cation tolerance protein 239762 5645004 A1C_01285 Rickettsia akari str. Hartford divalent cation tolerance protein YP_001493083.1 239448 R 293614 CDS YP_001493084.1 157825364 5645005 complement(239765..240208) 1 NC_009881.1 COG0720 6-pyruvoyl-tetrahydropterin synthase; hypothetical protein 240208 5645005 A1C_01290 Rickettsia akari str. Hartford hypothetical protein YP_001493084.1 239765 R 293614 CDS YP_001493085.1 157825365 5645020 complement(240318..241520) 1 NC_009881.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 241520 5645020 A1C_01295 Rickettsia akari str. Hartford dihydrolipoamide succinyltransferase YP_001493085.1 240318 R 293614 CDS YP_001493086.1 157825366 5645021 complement(241658..244444) 1 NC_009881.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 244444 sucA 5645021 sucA Rickettsia akari str. Hartford 2-oxoglutarate dehydrogenase E1 component YP_001493086.1 241658 R 293614 CDS YP_001493087.1 157825367 5645022 complement(244580..246067) 1 NC_009881.1 COG2317 Zn-dependent carboxypeptidase; thermostable carboxypeptidase 246067 5645022 A1C_01305 Rickettsia akari str. Hartford thermostable carboxypeptidase YP_001493087.1 244580 R 293614 CDS YP_001493088.1 157825368 5645023 complement(246246..247886) 1 NC_009881.1 COG0497 ATPase involved in DNA repair; DNA repair protein RecN 247886 5645023 A1C_01310 Rickettsia akari str. Hartford DNA repair protein RecN YP_001493088.1 246246 R 293614 CDS YP_001493089.1 157825369 5645024 complement(248071..248814) 1 NC_009881.1 COG4105 DNA uptake lipoprotein; hypothetical protein 248814 5645024 A1C_01315 Rickettsia akari str. Hartford hypothetical protein YP_001493089.1 248071 R 293614 CDS YP_001493090.1 157825370 5645025 complement(249082..249276) 1 NC_009881.1 COG4572 Putative cation transport regulator; cation transport regulator ChaB 249276 5645025 A1C_01320 Rickettsia akari str. Hartford cation transport regulator ChaB YP_001493090.1 249082 R 293614 CDS YP_001493091.1 157825371 5645026 complement(249502..250617) 1 NC_009881.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 250617 5645026 A1C_01325 Rickettsia akari str. Hartford chaperone protein DnaJ YP_001493091.1 249502 R 293614 CDS YP_001493092.1 157825372 5644876 complement(250806..252689) 1 NC_009881.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 252689 dnaK 5644876 dnaK Rickettsia akari str. Hartford molecular chaperone DnaK YP_001493092.1 250806 R 293614 CDS YP_001493093.1 157825373 5644877 252930..254423 1 NC_009881.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; heat shock protease 254423 5644877 A1C_01335 Rickettsia akari str. Hartford heat shock protease YP_001493093.1 252930 D 293614 CDS YP_001493094.1 157825374 5644878 254761..255252 1 NC_009881.1 ankyrin repeat-containing protein 255252 5644878 A1C_01340 Rickettsia akari str. Hartford ankyrin repeat-containing protein YP_001493094.1 254761 D 293614 CDS YP_001493095.1 157825375 5644879 complement(255508..255852) 1 NC_009881.1 hypothetical protein 255852 5644879 A1C_01345 Rickettsia akari str. Hartford hypothetical protein YP_001493095.1 255508 R 293614 CDS YP_001493096.1 157825376 5644880 256028..256501 1 NC_009881.1 hypothetical protein 256501 5644880 A1C_01350 Rickettsia akari str. Hartford hypothetical protein YP_001493096.1 256028 D 293614 CDS YP_001493097.1 157825377 5644881 256509..257489 1 NC_009881.1 required for the assembly and function of the DNAX complex which are required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 257489 holA 5644881 holA Rickettsia akari str. Hartford DNA polymerase III subunit delta YP_001493097.1 256509 D 293614 CDS YP_001493098.1 157825378 5644882 257689..258228 1 NC_009881.1 COG2941 Ubiquinone biosynthesis protein COQ7; ubiquinone biosynthesis protein Coq7 258228 5644882 A1C_01360 Rickettsia akari str. Hartford ubiquinone biosynthesis protein Coq7 YP_001493098.1 257689 D 293614 CDS YP_001493099.1 157825379 5644766 complement(258256..258414) 1 NC_009881.1 hypothetical protein 258414 5644766 A1C_01365 Rickettsia akari str. Hartford hypothetical protein YP_001493099.1 258256 R 293614 CDS YP_001493100.1 157825380 5644767 258912..259748 1 NC_009881.1 COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3; cytochrome c oxidase subunit III 259748 5644767 A1C_01370 Rickettsia akari str. Hartford cytochrome c oxidase subunit III YP_001493100.1 258912 D 293614 CDS YP_001493101.1 157825381 5644768 259904..260263 1 NC_009881.1 hypothetical protein 260263 5644768 A1C_01375 Rickettsia akari str. Hartford hypothetical protein YP_001493101.1 259904 D 293614 CDS YP_001493102.1 157825382 5644769 complement(260562..261182) 1 NC_009881.1 hypothetical protein 261182 5644769 A1C_01380 Rickettsia akari str. Hartford hypothetical protein YP_001493102.1 260562 R 293614 CDS YP_001493103.1 157825383 5644770 261266..262090 1 NC_009881.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 262090 dapD 5644770 dapD Rickettsia akari str. Hartford 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_001493103.1 261266 D 293614 CDS YP_001493104.1 157825384 5644771 complement(262627..262734) 1 NC_009881.1 hypothetical protein 262734 5644771 A1C_01390 Rickettsia akari str. Hartford hypothetical protein YP_001493104.1 262627 R 293614 CDS YP_001493105.1 157825385 5644772 complement(262758..263039) 1 NC_009881.1 COG0457 FOG: TPR repeat; hypothetical protein 263039 5644772 A1C_01395 Rickettsia akari str. Hartford hypothetical protein YP_001493105.1 262758 R 293614 CDS YP_001493106.1 157825386 5645622 complement(263531..263791) 1 NC_009881.1 hypothetical protein 263791 5645622 A1C_01400 Rickettsia akari str. Hartford hypothetical protein YP_001493106.1 263531 R 293614 CDS YP_001493107.1 157825387 5645623 complement(263824..263982) 1 NC_009881.1 hypothetical protein 263982 5645623 A1C_01405 Rickettsia akari str. Hartford hypothetical protein YP_001493107.1 263824 R 293614 CDS YP_001493108.1 157825388 5645624 complement(264225..266579) 1 NC_009881.1 COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC; bifunctional penicillin-binding protein 1C 266579 5645624 A1C_01410 Rickettsia akari str. Hartford bifunctional penicillin-binding protein 1C YP_001493108.1 264225 R 293614 CDS YP_001493109.1 157825389 5645625 267090..267401 1 NC_009881.1 cell surface antigen-like protein Sca8 267401 5645625 A1C_01415 Rickettsia akari str. Hartford cell surface antigen-like protein Sca8 YP_001493109.1 267090 D 293614 CDS YP_001493110.1 157825390 5645626 267472..267561 1 NC_009881.1 hypothetical protein 267561 5645626 A1C_01420 Rickettsia akari str. Hartford hypothetical protein YP_001493110.1 267472 D 293614 CDS YP_001493111.1 157825391 5645627 267826..268143 1 NC_009881.1 hypothetical protein 268143 5645627 A1C_01425 Rickettsia akari str. Hartford hypothetical protein YP_001493111.1 267826 D 293614 CDS YP_001493112.1 157825392 5645628 268272..268595 1 NC_009881.1 hypothetical protein 268595 5645628 A1C_01430 Rickettsia akari str. Hartford hypothetical protein YP_001493112.1 268272 D 293614 CDS YP_001493113.1 157825393 5645737 268704..268790 1 NC_009881.1 hypothetical protein 268790 5645737 A1C_01435 Rickettsia akari str. Hartford hypothetical protein YP_001493113.1 268704 D 293614 CDS YP_001493114.1 157825394 5645738 268854..268961 1 NC_009881.1 hypothetical protein 268961 5645738 A1C_01440 Rickettsia akari str. Hartford hypothetical protein YP_001493114.1 268854 D 293614 CDS YP_001493115.1 157825395 5645739 269047..269262 1 NC_009881.1 cell surface antigen-like protein Sca8 269262 5645739 A1C_01445 Rickettsia akari str. Hartford cell surface antigen-like protein Sca8 YP_001493115.1 269047 D 293614 CDS YP_001493116.1 157825396 5645740 269373..269534 1 NC_009881.1 cell surface antigen-like protein Sca8 269534 5645740 A1C_01450 Rickettsia akari str. Hartford cell surface antigen-like protein Sca8 YP_001493116.1 269373 D 293614 CDS YP_001493117.1 157825397 5645741 complement(269709..270155) 1 NC_009881.1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins; universal stress protein UspA 270155 5645741 A1C_01455 Rickettsia akari str. Hartford universal stress protein UspA YP_001493117.1 269709 R 293614 CDS YP_001493118.1 157825398 5645742 complement(270165..271106) 1 NC_009881.1 COG2358 TRAP-type uncharacterized transport system, periplasmic component; hypothetical protein 271106 5645742 A1C_01460 Rickettsia akari str. Hartford hypothetical protein YP_001493118.1 270165 R 293614 CDS YP_001493119.1 157825399 5645743 complement(271111..272181) 1 NC_009881.1 hypothetical protein 272181 5645743 A1C_01465 Rickettsia akari str. Hartford hypothetical protein YP_001493119.1 271111 R 293614 CDS YP_001493120.1 157825400 5644927 complement(272194..272532) 1 NC_009881.1 COG0633 Ferredoxin; ferredoxin 272532 5644927 A1C_01470 Rickettsia akari str. Hartford ferredoxin YP_001493120.1 272194 R 293614 CDS YP_001493121.1 157825401 5644928 complement(272594..274381) 1 NC_009881.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 274381 hscA 5644928 hscA Rickettsia akari str. Hartford chaperone protein HscA YP_001493121.1 272594 R 293614 CDS YP_001493122.1 157825402 5644929 complement(274372..274872) 1 NC_009881.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 274872 hscB 5644929 hscB Rickettsia akari str. Hartford co-chaperone HscB YP_001493122.1 274372 R 293614 CDS YP_001493123.1 157825403 5644930 275014..275595 1 NC_009881.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 275595 rnhB 5644930 rnhB Rickettsia akari str. Hartford ribonuclease HII YP_001493123.1 275014 D 293614 CDS YP_001493124.1 157825404 5644931 complement(275759..277744) 1 NC_009881.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 277744 5644931 A1C_01490 Rickettsia akari str. Hartford excinuclease ABC subunit B YP_001493124.1 275759 R 293614 CDS YP_001493125.1 157825405 5644932 277815..278108 1 NC_009881.1 COG0695 Glutaredoxin and related proteins; glutaredoxin 278108 5644932 A1C_01495 Rickettsia akari str. Hartford glutaredoxin YP_001493125.1 277815 D 293614 CDS YP_001493126.1 157825406 5644933 280551..283247 1 NC_009881.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 283247 5644933 A1C_01525 Rickettsia akari str. Hartford DNA gyrase subunit A YP_001493126.1 280551 D 293614 CDS YP_001493127.1 157825407 5645573 complement(283783..284058) 1 NC_009881.1 hypothetical protein 284058 5645573 A1C_01530 Rickettsia akari str. Hartford hypothetical protein YP_001493127.1 283783 R 293614 CDS YP_001493128.1 157825408 5645574 284970..285086 1 NC_009881.1 peptide deformylase 285086 def 5645574 def Rickettsia akari str. Hartford peptide deformylase YP_001493128.1 284970 D 293614 CDS YP_001493129.1 157825409 5645575 285238..285420 1 NC_009881.1 hypothetical protein 285420 5645575 A1C_01550 Rickettsia akari str. Hartford hypothetical protein YP_001493129.1 285238 D 293614 CDS YP_001493130.1 157825410 5645576 complement(285477..285662) 1 NC_009881.1 hypothetical protein 285662 5645576 A1C_01555 Rickettsia akari str. Hartford hypothetical protein YP_001493130.1 285477 R 293614 CDS YP_001493131.1 157825411 5645577 285876..286403 1 NC_009881.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 286403 def 5645577 def Rickettsia akari str. Hartford peptide deformylase YP_001493131.1 285876 D 293614 CDS YP_001493132.1 157825412 5645578 286415..287311 1 NC_009881.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 287311 fmt 5645578 fmt Rickettsia akari str. Hartford methionyl-tRNA formyltransferase YP_001493132.1 286415 D 293614 CDS YP_001493133.1 157825413 5645579 287428..287529 1 NC_009881.1 hypothetical protein 287529 5645579 A1C_01570 Rickettsia akari str. Hartford hypothetical protein YP_001493133.1 287428 D 293614 CDS YP_001493134.1 157825414 5645256 287754..287915 1 NC_009881.1 hypothetical protein 287915 5645256 A1C_01575 Rickettsia akari str. Hartford hypothetical protein YP_001493134.1 287754 D 293614 CDS YP_001493135.1 157825415 5645258 complement(292449..293501) 1 NC_009881.1 COG1485 Predicted ATPase; putative ATPase n2B 293501 5645258 A1C_01580 Rickettsia akari str. Hartford putative ATPase n2B YP_001493135.1 292449 R 293614 CDS YP_001493136.1 157825416 5645259 complement(293718..294833) 1 NC_009881.1 COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase); S-adenosylmethionine--tRNA ribosyltransferase-isomerase 294833 5645259 A1C_01585 Rickettsia akari str. Hartford S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_001493136.1 293718 R 293614 CDS YP_001493137.1 157825417 5645260 295270..295749 1 NC_009881.1 COG0666 FOG: Ankyrin repeat; hypothetical protein 295749 5645260 A1C_01590 Rickettsia akari str. Hartford hypothetical protein YP_001493137.1 295270 D 293614 CDS YP_001493138.1 157825418 5645261 295792..296037 1 NC_009881.1 hypothetical protein 296037 5645261 A1C_01595 Rickettsia akari str. Hartford hypothetical protein YP_001493138.1 295792 D 293614 CDS YP_001493139.1 157825419 5645432 complement(296235..298004) 1 NC_009881.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; multidrug ABC transporter ATP-binding protein 298004 5645432 A1C_01600 Rickettsia akari str. Hartford multidrug ABC transporter ATP-binding protein YP_001493139.1 296235 R 293614 CDS YP_001493140.1 157825420 5645433 298188..298469 1 NC_009881.1 hypothetical protein 298469 5645433 A1C_01605 Rickettsia akari str. Hartford hypothetical protein YP_001493140.1 298188 D 293614 CDS YP_001493141.1 157825421 5645434 298679..300034 1 NC_009881.1 COG1271 Cytochrome bd-type quinol oxidase, subunit 1; cytochrome d ubiquinol oxidase subunit I 300034 5645434 A1C_01610 Rickettsia akari str. Hartford cytochrome d ubiquinol oxidase subunit I YP_001493141.1 298679 D 293614 CDS YP_001493142.1 157825422 5645435 300129..301148 1 NC_009881.1 COG1294 Cytochrome bd-type quinol oxidase, subunit 2; cytochrome d ubiquinol oxidase subunit II 301148 5645435 A1C_01615 Rickettsia akari str. Hartford cytochrome d ubiquinol oxidase subunit II YP_001493142.1 300129 D 293614 CDS YP_001493143.1 157825423 5645436 301395..302270 1 NC_009881.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; beta 1,4 glucosyltransferase 302270 5645436 A1C_01620 Rickettsia akari str. Hartford beta 1,4 glucosyltransferase YP_001493143.1 301395 D 293614 CDS YP_001493144.1 157825424 5645437 302409..303647 1 NC_009881.1 COG0612 Predicted Zn-dependent peptidases; hypothetical protein 303647 5645437 A1C_01625 Rickettsia akari str. Hartford hypothetical protein YP_001493144.1 302409 D 293614 CDS YP_001493145.1 157825425 5645438 303728..304438 1 NC_009881.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 304438 5645438 A1C_01630 Rickettsia akari str. Hartford phosphoribosylaminoimidazole-succinocarboxamide synthase YP_001493145.1 303728 D 293614 CDS YP_001493146.1 157825426 5645658 304742..306343 1 NC_009881.1 hypothetical protein 306343 5645658 A1C_01635 Rickettsia akari str. Hartford hypothetical protein YP_001493146.1 304742 D 293614 CDS YP_001493147.1 157825427 5645659 306467..308374 1 NC_009881.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 308374 thrS 5645659 thrS Rickettsia akari str. Hartford threonyl-tRNA synthetase YP_001493147.1 306467 D 293614 CDS YP_001493148.1 157825428 5645660 308762..308878 1 NC_009881.1 multidrug ABC transporter ATPase and permease 308878 5645660 A1C_01645 Rickettsia akari str. Hartford multidrug ABC transporter ATPase and permease YP_001493148.1 308762 D 293614 CDS YP_001493149.1 157825429 5645661 complement(308967..309164) 1 NC_009881.1 hypothetical protein 309164 5645661 A1C_01650 Rickettsia akari str. Hartford hypothetical protein YP_001493149.1 308967 R 293614 CDS YP_001493150.1 157825430 5645662 complement(309568..309975) 1 NC_009881.1 hypothetical protein 309975 5645662 A1C_01655 Rickettsia akari str. Hartford hypothetical protein YP_001493150.1 309568 R 293614 CDS YP_001493151.1 157825431 5645663 complement(310589..310714) 1 NC_009881.1 hypothetical protein 310714 5645663 A1C_01660 Rickettsia akari str. Hartford hypothetical protein YP_001493151.1 310589 R 293614 CDS YP_001493152.1 157825432 5645664 complement(310788..311063) 1 NC_009881.1 hypothetical protein 311063 5645664 A1C_01665 Rickettsia akari str. Hartford hypothetical protein YP_001493152.1 310788 R 293614 CDS YP_001493153.1 157825433 5644970 311388..312752 1 NC_009881.1 COG1538 Outer membrane protein; TolC family type I secretion outer membrane protein 312752 5644970 A1C_01670 Rickettsia akari str. Hartford TolC family type I secretion outer membrane protein YP_001493153.1 311388 D 293614 CDS YP_001493154.1 157825434 5644971 312754..313152 1 NC_009881.1 COG3827 Uncharacterized protein conserved in bacteria; hypothetical protein 313152 5644971 A1C_01675 Rickettsia akari str. Hartford hypothetical protein YP_001493154.1 312754 D 293614 CDS YP_001493155.1 157825435 5644972 313215..315029 1 NC_009881.1 COG0666 FOG: Ankyrin repeat; ankyrin repeat-containing protein 315029 5644972 A1C_01680 Rickettsia akari str. Hartford ankyrin repeat-containing protein YP_001493155.1 313215 D 293614 CDS YP_001493156.1 157825436 5644973 315190..317178 1 NC_009881.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 317178 5644973 A1C_01685 Rickettsia akari str. Hartford DNA topoisomerase IV subunit B YP_001493156.1 315190 D 293614 CDS YP_001493157.1 157825437 5644974 317290..318639 1 NC_009881.1 COG0793 Periplasmic protease; tail-specific protease 318639 5644974 A1C_01690 Rickettsia akari str. Hartford tail-specific protease YP_001493157.1 317290 D 293614 CDS YP_001493158.1 157825438 5644975 318835..320328 1 NC_009881.1 COG0642 Signal transduction histidine kinase; histidine kinase sensor protein 320328 5644975 A1C_01695 Rickettsia akari str. Hartford histidine kinase sensor protein YP_001493158.1 318835 D 293614 CDS YP_001493159.1 157825439 5644976 320547..321284 1 NC_009881.1 COG1729 Uncharacterized protein conserved in bacteria; hypothetical protein 321284 5644976 A1C_01700 Rickettsia akari str. Hartford hypothetical protein YP_001493159.1 320547 D 293614 CDS YP_001493160.1 157825440 5645359 321297..321959 1 NC_009881.1 COG1038 Pyruvate carboxylase; hypothetical protein 321959 5645359 A1C_01705 Rickettsia akari str. Hartford hypothetical protein YP_001493160.1 321297 D 293614 CDS YP_001493161.1 157825441 5645360 321982..323226 1 NC_009881.1 COG1520 FOG: WD40-like repeat; WD-40 repeat-containing protein 323226 5645360 A1C_01710 Rickettsia akari str. Hartford WD-40 repeat-containing protein YP_001493161.1 321982 D 293614 CDS YP_001493162.1 157825442 5645361 323320..323787 1 NC_009881.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 323787 rplM 5645361 rplM Rickettsia akari str. Hartford 50S ribosomal protein L13 YP_001493162.1 323320 D 293614 CDS YP_001493163.1 157825443 5645362 323794..324279 1 NC_009881.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 324279 rpsI 5645362 rpsI Rickettsia akari str. Hartford 30S ribosomal protein S9 YP_001493163.1 323794 D 293614 CDS YP_001493164.1 157825444 5645364 324904..325011 1 NC_009881.1 hypothetical protein 325011 5645364 A1C_01725 Rickettsia akari str. Hartford hypothetical protein YP_001493164.1 324904 D 293614 CDS YP_001493165.1 157825445 5644963 325345..325476 1 NC_009881.1 COG2154 Pterin-4a-carbinolamine dehydratase; putative pterin-4-alpha-carbinolamine dehydratase (PHS) 325476 5644963 A1C_01730 Rickettsia akari str. Hartford putative pterin-4-alpha-carbinolamine dehydratase (PHS) YP_001493165.1 325345 D 293614 CDS YP_001493166.1 157825446 5644964 325911..326312 1 NC_009881.1 hypothetical protein 326312 5644964 A1C_01735 Rickettsia akari str. Hartford hypothetical protein YP_001493166.1 325911 D 293614 CDS YP_001493167.1 157825447 5644965 complement(326651..327136) 1 NC_009881.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 327136 5644965 A1C_01740 Rickettsia akari str. Hartford dinucleoside polyphosphate hydrolase YP_001493167.1 326651 R 293614 CDS YP_001493168.1 157825448 5644966 complement(327160..328512) 1 NC_009881.1 involved in swarmer-to-stalked cell differentiation in Caulobacter crescentus; catalyzes the condensation of two GTP molecules to form the secondary messenger cyclic di-GMP (c-di-GMP); upon phosphorylation of domain D1 the protein dimerizes; presumably this allows the two GTP-bound GGDEF (diguanylate cyclase) domains to catalyze the condensation reaction; allosterically inhibited by c-di-GMP; response regulator PleD 328512 pleD 5644966 pleD Rickettsia akari str. Hartford response regulator PleD YP_001493168.1 327160 R 293614 CDS YP_001493169.1 157825449 5644967 328588..329154 1 NC_009881.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 329154 5644967 A1C_01750 Rickettsia akari str. Hartford elongation factor P YP_001493169.1 328588 D 293614 CDS YP_001493170.1 157825450 5644968 329164..329910 1 NC_009881.1 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family; extragenic suppressor protein SuhB 329910 5644968 A1C_01755 Rickettsia akari str. Hartford extragenic suppressor protein SuhB YP_001493170.1 329164 D 293614 CDS YP_001493171.1 157825451 5644969 330151..330474 1 NC_009881.1 hypothetical protein 330474 5644969 A1C_01760 Rickettsia akari str. Hartford hypothetical protein YP_001493171.1 330151 D 293614 CDS YP_001493172.1 157825452 5645608 330554..331249 1 NC_009881.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 331249 5645608 A1C_01765 Rickettsia akari str. Hartford phosphatidylserine decarboxylase YP_001493172.1 330554 D 293614 CDS YP_001493173.1 157825453 5645609 331415..332182 1 NC_009881.1 COG1183 Phosphatidylserine synthase; CDP-diacylglycerol--serine O-phosphatidyltransferase 332182 5645609 A1C_01770 Rickettsia akari str. Hartford CDP-diacylglycerol--serine O-phosphatidyltransferase YP_001493173.1 331415 D 293614 CDS YP_001493174.1 157825454 5645610 332191..333243 1 NC_009881.1 COG1566 Multidrug resistance efflux pump; multidrug resistance protein A 333243 5645610 A1C_01775 Rickettsia akari str. Hartford multidrug resistance protein A YP_001493174.1 332191 D 293614 CDS YP_001493175.1 157825455 5645611 333441..333518 1 NC_009881.1 hypothetical protein 333518 5645611 A1C_01780 Rickettsia akari str. Hartford hypothetical protein YP_001493175.1 333441 D 293614 CDS YP_001493176.1 157825456 5645612 complement(333681..333884) 1 NC_009881.1 hypothetical protein 333884 5645612 A1C_01785 Rickettsia akari str. Hartford hypothetical protein YP_001493176.1 333681 R 293614 CDS YP_001493177.1 157825457 5645613 complement(333881..334123) 1 NC_009881.1 COG0271 Stress-induced morphogen (activity unknown); hypothetical protein 334123 5645613 A1C_01790 Rickettsia akari str. Hartford hypothetical protein YP_001493177.1 333881 R 293614 CDS YP_001493178.1 157825458 5645614 334178..335395 1 NC_009881.1 COG1022 Long-chain acyl-CoA synthetases (AMP-forming); hypothetical protein 335395 5645614 A1C_01795 Rickettsia akari str. Hartford hypothetical protein YP_001493178.1 334178 D 293614 CDS YP_001493179.1 157825459 5645117 335513..336949 1 NC_009881.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 336949 murC 5645117 murC Rickettsia akari str. Hartford UDP-N-acetylmuramate--L-alanine ligase YP_001493179.1 335513 D 293614 CDS YP_001493180.1 157825460 5645118 336996..337883 1 NC_009881.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 337883 murB 5645118 murB Rickettsia akari str. Hartford UDP-N-acetylenolpyruvoylglucosamine reductase YP_001493180.1 336996 D 293614 CDS YP_001493181.1 157825461 5645119 338040..339002 1 NC_009881.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 339002 ddl 5645119 ddl Rickettsia akari str. Hartford D-alanine--D-alanine ligase YP_001493181.1 338040 D 293614 CDS YP_001493182.1 157825462 5645120 339592..339801 1 NC_009881.1 COG1589 Cell division septal protein; cell division protein FtsQ 339801 5645120 A1C_01815 Rickettsia akari str. Hartford cell division protein FtsQ YP_001493182.1 339592 D 293614 CDS YP_001493183.1 157825463 5645121 339950..341185 1 NC_009881.1 COG0849 Actin-like ATPase involved in cell division; cell division protein FtsA 341185 5645121 A1C_01820 Rickettsia akari str. Hartford cell division protein FtsA YP_001493183.1 339950 D 293614 CDS YP_001493184.1 157825464 5645122 complement(341116..341310) 1 NC_009881.1 hypothetical protein 341310 5645122 A1C_01825 Rickettsia akari str. Hartford hypothetical protein YP_001493184.1 341116 R 293614 CDS YP_001493185.1 157825465 5645123 complement(341543..341710) 1 NC_009881.1 hypothetical protein 341710 5645123 A1C_01830 Rickettsia akari str. Hartford hypothetical protein YP_001493185.1 341543 R 293614 CDS YP_001493186.1 157825466 5645201 complement(342230..342556) 1 NC_009881.1 COG1585 Membrane protein implicated in regulation of membrane protease activity; hypothetical protein 342556 5645201 A1C_01835 Rickettsia akari str. Hartford hypothetical protein YP_001493186.1 342230 R 293614 CDS YP_001493187.1 157825467 5645202 complement(342546..343073) 1 NC_009881.1 COG3474 Cytochrome c2; cytochrome c 343073 5645202 A1C_01840 Rickettsia akari str. Hartford cytochrome c YP_001493187.1 342546 R 293614 CDS YP_001493188.1 157825468 5645203 343187..344257 1 NC_009881.1 hypothetical protein 344257 5645203 A1C_01845 Rickettsia akari str. Hartford hypothetical protein YP_001493188.1 343187 D 293614 CDS YP_001493189.1 157825469 5645204 complement(344266..345132) 1 NC_009881.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 345132 lpxC 5645204 lpxC Rickettsia akari str. Hartford UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_001493189.1 344266 R 293614 CDS YP_001493190.1 157825470 5645205 complement(345385..346533) 1 NC_009881.1 hypothetical protein 346533 5645205 A1C_01855 Rickettsia akari str. Hartford hypothetical protein YP_001493190.1 345385 R 293614 CDS YP_001493191.1 157825471 5645206 346962..349034 1 NC_009881.1 COG1530 Ribonucleases G and E; ribonuclease E 349034 5645206 A1C_01860 Rickettsia akari str. Hartford ribonuclease E YP_001493191.1 346962 D 293614 CDS YP_001493192.1 157825472 5645207 349210..350166 1 NC_009881.1 COG1612 Uncharacterized protein required for cytochrome oxidase assembly; cytochrome c oxidase assembly protein 350166 5645207 A1C_01865 Rickettsia akari str. Hartford cytochrome c oxidase assembly protein YP_001493192.1 349210 D 293614 CDS YP_001493193.1 157825473 5645033 350364..351275 1 NC_009881.1 COG0564 Pseudouridylate synthases, 23S RNA-specific; ribosomal large subunit pseudouridine synthase C 351275 5645033 A1C_01870 Rickettsia akari str. Hartford ribosomal large subunit pseudouridine synthase C YP_001493193.1 350364 D 293614 CDS YP_001493194.1 157825474 5645034 351424..352617 1 NC_009881.1 COG1680 Beta-lactamase class C and other penicillin binding proteins; penicillin-binding protein 4* 352617 5645034 A1C_01875 Rickettsia akari str. Hartford penicillin-binding protein 4* YP_001493194.1 351424 D 293614 CDS YP_001493195.1 157825475 5645035 352631..353464 1 NC_009881.1 COG0708 Exonuclease III; exodeoxyribonuclease III 353464 5645035 A1C_01880 Rickettsia akari str. Hartford exodeoxyribonuclease III YP_001493195.1 352631 D 293614 CDS YP_001493196.1 157825476 5645036 353506..354486 1 NC_009881.1 COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit; pyruvate dehydrogenase e1 component subunit alpha 354486 5645036 A1C_01885 Rickettsia akari str. Hartford pyruvate dehydrogenase e1 component subunit alpha YP_001493196.1 353506 D 293614 CDS YP_001493197.1 157825477 5645037 354594..355574 1 NC_009881.1 catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acyltransferase within the complex. The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2); it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase; pyruvate dehydrogenase subunit beta 355574 5645037 A1C_01890 Rickettsia akari str. Hartford pyruvate dehydrogenase subunit beta YP_001493197.1 354594 D 293614 CDS YP_001493198.1 157825478 5645038 complement(355762..357591) 1 NC_009881.1 COG1217 Predicted membrane GTPase involved in stress response; GTP-binding protein TypA 357591 5645038 A1C_01895 Rickettsia akari str. Hartford GTP-binding protein TypA YP_001493198.1 355762 R 293614 CDS YP_001493199.1 157825479 5645039 357791..357955 1 NC_009881.1 hypothetical protein 357955 5645039 A1C_01900 Rickettsia akari str. Hartford hypothetical protein YP_001493199.1 357791 D 293614 CDS YP_001493200.1 157825480 5645151 357948..358127 1 NC_009881.1 hypothetical protein 358127 5645151 A1C_01905 Rickettsia akari str. Hartford hypothetical protein YP_001493200.1 357948 D 293614 CDS YP_001493201.1 157825481 5645152 358096..358377 1 NC_009881.1 hypothetical protein 358377 5645152 A1C_01910 Rickettsia akari str. Hartford hypothetical protein YP_001493201.1 358096 D 293614 CDS YP_001493202.1 157825482 5645153 358789..359295 1 NC_009881.1 COG2825 Outer membrane protein; hypothetical protein 359295 5645153 A1C_01915 Rickettsia akari str. Hartford hypothetical protein YP_001493202.1 358789 D 293614 CDS YP_001493203.1 157825483 5645154 359376..360827 1 NC_009881.1 catalyzes the formation of 2-oxoglutarate from isocitrate; isocitrate dehydrogenase 360827 5645154 A1C_01920 Rickettsia akari str. Hartford isocitrate dehydrogenase YP_001493203.1 359376 D 293614 CDS YP_001493204.1 157825484 5645155 360985..361329 1 NC_009881.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport; putative monovalent cation/H+ antiporter subunit G 361329 5645155 A1C_01925 Rickettsia akari str. Hartford putative monovalent cation/H+ antiporter subunit G YP_001493204.1 360985 D 293614 CDS YP_001493205.1 157825485 5645156 361364..362410 1 NC_009881.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit B 362410 5645156 A1C_01930 Rickettsia akari str. Hartford putative monovalent cation/H+ antiporter subunit B YP_001493205.1 361364 D 293614 CDS YP_001493206.1 157825486 5645157 362533..363171 1 NC_009881.1 Heme exporter protein B 363171 5645157 A1C_01935 Rickettsia akari str. Hartford Heme exporter protein B YP_001493206.1 362533 D 293614 CDS YP_001493207.1 157825487 5645110 363248..363706 1 NC_009881.1 hypothetical protein 363706 5645110 A1C_01940 Rickettsia akari str. Hartford hypothetical protein YP_001493207.1 363248 D 293614 CDS YP_001493208.1 157825488 5645111 363728..364261 1 NC_009881.1 COG0723 Rieske Fe-S protein; ubiquinol-cytochrome c reductase, iron-sulfur subunit 364261 5645111 A1C_01945 Rickettsia akari str. Hartford ubiquinol-cytochrome c reductase, iron-sulfur subunit YP_001493208.1 363728 D 293614 CDS YP_001493209.1 157825489 5645112 364268..365611 1 NC_009881.1 COG1290 Cytochrome b subunit of the bc complex; cytochrome b 365611 5645112 A1C_01950 Rickettsia akari str. Hartford cytochrome b YP_001493209.1 364268 D 293614 CDS YP_001493210.1 157825490 5645113 365813..366568 1 NC_009881.1 COG2857 Cytochrome c1; cytochrome c1, heme protein 366568 5645113 A1C_01955 Rickettsia akari str. Hartford cytochrome c1, heme protein YP_001493210.1 365813 D 293614 CDS YP_001493211.1 157825491 5645114 366881..367054 1 NC_009881.1 hypothetical protein 367054 5645114 A1C_01960 Rickettsia akari str. Hartford hypothetical protein YP_001493211.1 366881 D 293614 CDS YP_001493212.1 157825492 5645115 367381..367872 1 NC_009881.1 COG0071 Molecular chaperone (small heat shock protein); heat shock protein 367872 5645115 A1C_01965 Rickettsia akari str. Hartford heat shock protein YP_001493212.1 367381 D 293614 CDS YP_001493213.1 157825493 5645116 complement(368895..369752) 1 NC_009881.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 369752 prfB 5645116 prfB Rickettsia akari str. Hartford peptide chain release factor 2 YP_001493213.1 368895 R 293614 CDS YP_001493214.1 157825494 5645531 370172..371974 1 NC_009881.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 371974 5645531 A1C_01975 Rickettsia akari str. Hartford GTP-binding protein LepA YP_001493214.1 370172 D 293614 CDS YP_001493215.1 157825495 5645533 372474..372656 1 NC_009881.1 putative phage-like protein 372656 5645533 A1C_01980 Rickettsia akari str. Hartford putative phage-like protein YP_001493215.1 372474 D 293614 CDS YP_001493216.1 157825496 5645534 complement(372781..372936) 1 NC_009881.1 COG3093 Plasmid maintenance system antidote protein; hypothetical protein 372936 5645534 A1C_01985 Rickettsia akari str. Hartford hypothetical protein YP_001493216.1 372781 R 293614 CDS YP_001493217.1 157825497 5645535 373019..373216 1 NC_009881.1 COG1943 Transposase and inactivated derivatives; transposase IS200-family protein 373216 5645535 A1C_01990 Rickettsia akari str. Hartford transposase IS200-family protein YP_001493217.1 373019 D 293614 CDS YP_001493218.1 157825498 5645536 complement(373251..374351) 1 NC_009881.1 COG0772 Bacterial cell division membrane protein; rod shape-determining protein RodA 374351 5645536 A1C_01995 Rickettsia akari str. Hartford rod shape-determining protein RodA YP_001493218.1 373251 R 293614 CDS YP_001493219.1 157825499 5645651 complement(374457..376511) 1 NC_009881.1 COG1770 Protease II; protease II 376511 5645651 A1C_02000 Rickettsia akari str. Hartford protease II YP_001493219.1 374457 R 293614 CDS YP_001493220.1 157825500 5645652 complement(376543..378075) 1 NC_009881.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; putative monovalent cation/H+ antiporter subunit D 378075 5645652 A1C_02005 Rickettsia akari str. Hartford putative monovalent cation/H+ antiporter subunit D YP_001493220.1 376543 R 293614 CDS YP_001493221.1 157825501 5645653 complement(378077..378271) 1 NC_009881.1 toxin of toxin-antitoxin system VapC 378271 5645653 A1C_02010 Rickettsia akari str. Hartford toxin of toxin-antitoxin system VapC YP_001493221.1 378077 R 293614 CDS YP_001493222.1 157825502 5645654 complement(378813..380276) 1 NC_009881.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; putative monovalent cation/H+ antiporter subunit D 380276 5645654 A1C_02015 Rickettsia akari str. Hartford putative monovalent cation/H+ antiporter subunit D YP_001493222.1 378813 R 293614 CDS YP_001493223.1 157825503 5645655 380191..380295 1 NC_009881.1 putative monovalent cation/H+ antiporter subunit D 380295 5645655 A1C_02020 Rickettsia akari str. Hartford putative monovalent cation/H+ antiporter subunit D YP_001493223.1 380191 D 293614 CDS YP_001493224.1 157825504 5645656 complement(380497..381597) 1 NC_009881.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; putative monovalent cation/H+ antiporter subunit D 381597 5645656 A1C_02025 Rickettsia akari str. Hartford putative monovalent cation/H+ antiporter subunit D YP_001493224.1 380497 R 293614 CDS YP_001493225.1 157825505 5645657 381653..381796 1 NC_009881.1 putative monovalent cation/H+ antiporter subunit C 381796 5645657 A1C_02030 Rickettsia akari str. Hartford putative monovalent cation/H+ antiporter subunit C YP_001493225.1 381653 D 293614 CDS YP_001493226.1 157825506 5645403 complement(381780..382115) 1 NC_009881.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit C 382115 5645403 A1C_02035 Rickettsia akari str. Hartford putative monovalent cation/H+ antiporter subunit C YP_001493226.1 381780 R 293614 CDS YP_001493227.1 157825507 5645404 complement(382294..383046) 1 NC_009881.1 COG3504 Type IV secretory pathway, VirB9 components; VirB9 protein 383046 5645404 A1C_02040 Rickettsia akari str. Hartford VirB9 protein YP_001493227.1 382294 R 293614 CDS YP_001493228.1 157825508 5645405 complement(383048..383746) 1 NC_009881.1 COG3736 Type IV secretory pathway, component VirB8; VirB8 protein 383746 5645405 A1C_02045 Rickettsia akari str. Hartford VirB8 protein YP_001493228.1 383048 R 293614 CDS YP_001493229.1 157825509 5645406 384210..384389 1 NC_009881.1 hypothetical protein 384389 5645406 A1C_02050 Rickettsia akari str. Hartford hypothetical protein YP_001493229.1 384210 D 293614 CDS YP_001493230.1 157825510 5645407 384440..385171 1 NC_009881.1 COG3736 Type IV secretory pathway, component VirB8; VirB8 protein 385171 5645407 A1C_02055 Rickettsia akari str. Hartford VirB8 protein YP_001493230.1 384440 D 293614 CDS YP_001493231.1 157825511 5645408 385158..385634 1 NC_009881.1 COG3504 Type IV secretory pathway, VirB9 components; VirB9 protein precursor 385634 5645408 A1C_02060 Rickettsia akari str. Hartford VirB9 protein precursor YP_001493231.1 385158 D 293614 CDS YP_001493232.1 157825512 5645409 385779..387233 1 NC_009881.1 COG2948 Type IV secretory pathway, VirB10 components; virB10 protein 387233 5645409 A1C_02065 Rickettsia akari str. Hartford virB10 protein YP_001493232.1 385779 D 293614 CDS YP_001493233.1 157825513 5645559 387230..388234 1 NC_009881.1 COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis; type IV secretion system ATPase VirB11 388234 5645559 A1C_02070 Rickettsia akari str. Hartford type IV secretion system ATPase VirB11 YP_001493233.1 387230 D 293614 CDS YP_001493234.1 157825514 5645560 388397..390172 1 NC_009881.1 COG3505 Type IV secretory pathway, VirD4 components; type IV secretion system protein VirB8 390172 5645560 A1C_02075 Rickettsia akari str. Hartford type IV secretion system protein VirB8 YP_001493234.1 388397 D 293614 CDS YP_001493235.1 157825515 5645561 390182..391594 1 NC_009881.1 COG0248 Exopolyphosphatase; guanosine pentaphosphate phosphohydrolase 391594 5645561 A1C_02080 Rickettsia akari str. Hartford guanosine pentaphosphate phosphohydrolase YP_001493235.1 390182 D 293614 CDS YP_001493236.1 157825516 5645562 393376..393597 1 NC_009881.1 cell surface antigen-like protein Sca7 393597 5645562 A1C_02105 Rickettsia akari str. Hartford cell surface antigen-like protein Sca7 YP_001493236.1 393376 D 293614 CDS YP_001493237.1 157825517 5645563 393606..393824 1 NC_009881.1 cell surface antigen-like protein Sca7 393824 5645563 A1C_02110 Rickettsia akari str. Hartford cell surface antigen-like protein Sca7 YP_001493237.1 393606 D 293614 CDS YP_001493238.1 157825518 5645564 393836..394366 1 NC_009881.1 cell surface antigen-like protein Sca7 394366 5645564 A1C_02115 Rickettsia akari str. Hartford cell surface antigen-like protein Sca7 YP_001493238.1 393836 D 293614 CDS YP_001493239.1 157825519 5645565 394596..394814 1 NC_009881.1 cell surface antigen-like protein Sca7 394814 5645565 A1C_02120 Rickettsia akari str. Hartford cell surface antigen-like protein Sca7 YP_001493239.1 394596 D 293614 CDS YP_001493241.1 157825521 5645695 395226..395540 1 NC_009881.1 protein transport protein sec7 (sec7) 395540 5645695 A1C_02130 Rickettsia akari str. Hartford protein transport protein sec7 (sec7) YP_001493241.1 395226 D 293614 CDS YP_001493242.1 157825522 5645696 395825..396022 1 NC_009881.1 COG1943 Transposase and inactivated derivatives; transposase IS200-family protein 396022 5645696 A1C_02135 Rickettsia akari str. Hartford transposase IS200-family protein YP_001493242.1 395825 D 293614 CDS YP_001493243.1 157825523 5645697 396033..396242 1 NC_009881.1 cell surface antigen-like protein Sca7 396242 5645697 A1C_02140 Rickettsia akari str. Hartford cell surface antigen-like protein Sca7 YP_001493243.1 396033 D 293614 CDS YP_001493244.1 157825524 5645698 396274..396501 1 NC_009881.1 cell surface antigen-like protein Sca7 396501 5645698 A1C_02145 Rickettsia akari str. Hartford cell surface antigen-like protein Sca7 YP_001493244.1 396274 D 293614 CDS YP_001493245.1 157825525 5645699 396501..397385 1 NC_009881.1 cell surface antigen Sca3 397385 5645699 A1C_02150 Rickettsia akari str. Hartford cell surface antigen Sca3 YP_001493245.1 396501 D 293614 CDS YP_001493246.1 157825526 5645700 complement(397382..397600) 1 NC_009881.1 hypothetical protein 397600 5645700 A1C_02155 Rickettsia akari str. Hartford hypothetical protein YP_001493246.1 397382 R 293614 CDS YP_001493247.1 157825527 5645701 398228..398338 1 NC_009881.1 transposase 398338 5645701 A1C_02160 Rickettsia akari str. Hartford transposase YP_001493247.1 398228 D 293614 CDS YP_001493248.1 157825528 5645238 398406..398684 1 NC_009881.1 transposase 398684 5645238 A1C_02165 Rickettsia akari str. Hartford transposase YP_001493248.1 398406 D 293614 CDS YP_001493249.1 157825529 5645239 complement(400901..401062) 1 NC_009881.1 hypothetical protein 401062 5645239 A1C_02180 Rickettsia akari str. Hartford hypothetical protein YP_001493249.1 400901 R 293614 CDS YP_001493250.1 157825530 5645240 complement(401064..401297) 1 NC_009881.1 hypothetical protein 401297 5645240 A1C_02185 Rickettsia akari str. Hartford hypothetical protein YP_001493250.1 401064 R 293614 CDS YP_001493251.1 157825531 5645241 complement(401496..401744) 1 NC_009881.1 hypothetical protein 401744 5645241 A1C_02190 Rickettsia akari str. Hartford hypothetical protein YP_001493251.1 401496 R 293614 CDS YP_001493252.1 157825532 5645242 401964..402851 1 NC_009881.1 hypothetical protein 402851 5645242 A1C_02195 Rickettsia akari str. Hartford hypothetical protein YP_001493252.1 401964 D 293614 CDS YP_001493253.1 157825533 5645243 402835..403680 1 NC_009881.1 hypothetical protein 403680 5645243 A1C_02200 Rickettsia akari str. Hartford hypothetical protein YP_001493253.1 402835 D 293614 CDS YP_001493254.1 157825534 5645244 403977..404756 1 NC_009881.1 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase; cysQ protein 404756 5645244 A1C_02205 Rickettsia akari str. Hartford cysQ protein YP_001493254.1 403977 D 293614 CDS YP_001493255.1 157825535 5644692 complement(404869..407529) 1 NC_009881.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 407529 5644692 A1C_02210 Rickettsia akari str. Hartford DNA mismatch repair protein MutS YP_001493255.1 404869 R 293614 CDS YP_001493256.1 157825536 5644693 408062..408226 1 NC_009881.1 hypothetical protein 408226 5644693 A1C_02215 Rickettsia akari str. Hartford hypothetical protein YP_001493256.1 408062 D 293614 CDS YP_001493257.1 157825537 5644694 complement(409553..409987) 1 NC_009881.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 409987 5644694 A1C_02230 Rickettsia akari str. Hartford ribose-5-phosphate isomerase B YP_001493257.1 409553 R 293614 CDS YP_001493258.1 157825538 5644695 410030..410707 1 NC_009881.1 COG0739 Membrane proteins related to metalloendopeptidases; metalloendopeptidase-like membrane protein 410707 5644695 A1C_02235 Rickettsia akari str. Hartford metalloendopeptidase-like membrane protein YP_001493258.1 410030 D 293614 CDS YP_001493259.1 157825539 5644696 411429..411554 1 NC_009881.1 COG2161 Antitoxin of toxin-antitoxin stability system; antitoxin of toxin-antitoxin stability system 411554 5644696 A1C_02250 Rickettsia akari str. Hartford antitoxin of toxin-antitoxin stability system YP_001493259.1 411429 D 293614 CDS YP_001493260.1 157825540 5644697 411695..411853 1 NC_009881.1 COG4115 Uncharacterized protein conserved in bacteria; toxin of toxin-antitoxin system 411853 5644697 A1C_02255 Rickettsia akari str. Hartford toxin of toxin-antitoxin system YP_001493260.1 411695 D 293614 CDS YP_001493261.1 157825541 5644698 411948..412832 1 NC_009881.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 412832 thyX 5644698 thyX Rickettsia akari str. Hartford FAD-dependent thymidylate synthase YP_001493261.1 411948 D 293614 CDS YP_001493262.1 157825542 5645460 412988..414322 1 NC_009881.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 414322 tolB 5645460 tolB Rickettsia akari str. Hartford translocation protein TolB YP_001493262.1 412988 D 293614 CDS YP_001493263.1 157825543 5645461 complement(414458..415339) 1 NC_009881.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 415339 5645461 A1C_02270 Rickettsia akari str. Hartford RNA polymerase factor sigma-32 YP_001493263.1 414458 R 293614 CDS YP_001493264.1 157825544 5645462 415425..415970 1 NC_009881.1 involved in the insertion of copper into subunit I of cytochrome C oxidase; cytochrome C oxidase assembly protein 415970 5645462 A1C_02275 Rickettsia akari str. Hartford cytochrome C oxidase assembly protein YP_001493264.1 415425 D 293614 CDS YP_001493265.1 157825545 5645463 complement(416183..417160) 1 NC_009881.1 hypothetical protein 417160 5645463 A1C_02280 Rickettsia akari str. Hartford hypothetical protein YP_001493265.1 416183 R 293614 CDS YP_001493266.1 157825546 5645464 417410..418507 1 NC_009881.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 418507 mnmA 5645464 mnmA Rickettsia akari str. Hartford tRNA-specific 2-thiouridylase MnmA YP_001493266.1 417410 D 293614 CDS YP_001493267.1 157825547 5645465 418585..419976 1 NC_009881.1 COG0531 Amino acid transporters; cationic amino acid transporter-1 419976 5645465 A1C_02290 Rickettsia akari str. Hartford cationic amino acid transporter-1 YP_001493267.1 418585 D 293614 CDS YP_001493268.1 157825548 5645466 420129..421376 1 NC_009881.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 421376 hisS 5645466 hisS Rickettsia akari str. Hartford histidyl-tRNA synthetase YP_001493268.1 420129 D 293614 CDS YP_001493269.1 157825549 5645601 421440..421802 1 NC_009881.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATP-binding protein 421802 5645601 A1C_02300 Rickettsia akari str. Hartford ABC transporter ATP-binding protein YP_001493269.1 421440 D 293614 CDS YP_001493270.1 157825550 5645602 421888..422103 1 NC_009881.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATP-binding protein 422103 5645602 A1C_02305 Rickettsia akari str. Hartford ABC transporter ATP-binding protein YP_001493270.1 421888 D 293614 CDS YP_001493271.1 157825551 5645603 423131..423856 1 NC_009881.1 COG0811 Biopolymer transport proteins; TolQ protein 423856 5645603 A1C_02310 Rickettsia akari str. Hartford TolQ protein YP_001493271.1 423131 D 293614 CDS YP_001493272.1 157825552 5645604 423856..424287 1 NC_009881.1 COG0848 Biopolymer transport protein; TolR protein 424287 5645604 A1C_02315 Rickettsia akari str. Hartford TolR protein YP_001493272.1 423856 D 293614 CDS YP_001493273.1 157825553 5645605 424277..425257 1 NC_009881.1 periplasmic protein TonB 425257 5645605 A1C_02320 Rickettsia akari str. Hartford periplasmic protein TonB YP_001493273.1 424277 D 293614 CDS YP_001493274.1 157825554 5645606 complement(425757..426134) 1 NC_009881.1 COG1266 Predicted metal-dependent membrane protease; hypothetical protein 426134 5645606 A1C_02325 Rickettsia akari str. Hartford hypothetical protein YP_001493274.1 425757 R 293614 CDS YP_001493275.1 157825555 5645607 426823..427317 1 NC_009881.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; hypothetical protein 427317 5645607 A1C_02330 Rickettsia akari str. Hartford hypothetical protein YP_001493275.1 426823 D 293614 CDS YP_001493276.1 157825556 5645216 complement(427268..428641) 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; proline/betaine transporter 428641 5645216 A1C_02335 Rickettsia akari str. Hartford proline/betaine transporter YP_001493276.1 427268 R 293614 CDS YP_001493277.1 157825557 5645217 complement(428725..430260) 1 NC_009881.1 COG0845 Membrane-fusion protein; alkaline protease secretion protein AprE 430260 5645217 A1C_02340 Rickettsia akari str. Hartford alkaline protease secretion protein AprE YP_001493277.1 428725 R 293614 CDS YP_001493278.1 157825558 5645218 complement(430457..432235) 1 NC_009881.1 COG4618 ABC-type protease/lipase transport system, ATPase and permease components; alkaline protease secretion ATP-binding protein AprD 432235 5645218 A1C_02345 Rickettsia akari str. Hartford alkaline protease secretion ATP-binding protein AprD YP_001493278.1 430457 R 293614 CDS YP_001493279.1 157825559 5645219 complement(432222..433238) 1 NC_009881.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 433238 5645219 A1C_02350 Rickettsia akari str. Hartford aspartate-semialdehyde dehydrogenase YP_001493279.1 432222 R 293614 CDS YP_001493280.1 157825560 5645220 complement(433231..433593) 1 NC_009881.1 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; protein kinase C inhibitor 1 433593 5645220 A1C_02355 Rickettsia akari str. Hartford protein kinase C inhibitor 1 YP_001493280.1 433231 R 293614 CDS YP_001493281.1 157825561 5645221 complement(433818..434051) 1 NC_009881.1 hypothetical protein 434051 5645221 A1C_02360 Rickettsia akari str. Hartford hypothetical protein YP_001493281.1 433818 R 293614 CDS YP_001493282.1 157825562 5645222 434562..435110 1 NC_009881.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 435110 5645222 A1C_02365 Rickettsia akari str. Hartford ATP-dependent protease peptidase subunit YP_001493282.1 434562 D 293614 CDS YP_001493283.1 157825563 5645789 435107..436459 1 NC_009881.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 436459 hslU 5645789 hslU Rickettsia akari str. Hartford ATP-dependent protease ATP-binding subunit HslU YP_001493283.1 435107 D 293614 CDS YP_001493284.1 157825564 5645790 436652..436720 1 NC_009881.1 lipid-A-disaccharide synthase 436720 lpxB 5645790 lpxB Rickettsia akari str. Hartford lipid-A-disaccharide synthase YP_001493284.1 436652 D 293614 CDS YP_001493285.1 157825565 5645791 436733..437908 1 NC_009881.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 437908 lpxB 5645791 lpxB Rickettsia akari str. Hartford lipid-A-disaccharide synthase YP_001493285.1 436733 D 293614 CDS YP_001493286.1 157825566 5645792 complement(437888..438169) 1 NC_009881.1 hypothetical protein 438169 5645792 A1C_02385 Rickettsia akari str. Hartford hypothetical protein YP_001493286.1 437888 R 293614 CDS YP_001493287.1 157825567 5645793 438485..439534 1 NC_009881.1 COG1559 Predicted periplasmic solute-binding protein; hypothetical protein 439534 5645793 A1C_02390 Rickettsia akari str. Hartford hypothetical protein YP_001493287.1 438485 D 293614 CDS YP_001493288.1 157825568 5645794 439581..439886 1 NC_009881.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 439886 cyaY 5645794 cyaY Rickettsia akari str. Hartford frataxin-like protein YP_001493288.1 439581 D 293614 CDS YP_001493289.1 157825569 5645795 440370..440480 1 NC_009881.1 hypothetical protein 440480 5645795 A1C_02410 Rickettsia akari str. Hartford hypothetical protein YP_001493289.1 440370 D 293614 CDS YP_001493290.1 157825570 5645144 440495..440623 1 NC_009881.1 hypothetical protein 440623 5645144 A1C_02415 Rickettsia akari str. Hartford hypothetical protein YP_001493290.1 440495 D 293614 CDS YP_001493291.1 157825571 5645145 440670..440873 1 NC_009881.1 hypothetical protein 440873 5645145 A1C_02420 Rickettsia akari str. Hartford hypothetical protein YP_001493291.1 440670 D 293614 CDS YP_001493292.1 157825572 5645146 441000..441077 1 NC_009881.1 hypothetical protein 441077 5645146 A1C_02425 Rickettsia akari str. Hartford hypothetical protein YP_001493292.1 441000 D 293614 CDS YP_001493293.1 157825573 5645147 441362..441742 1 NC_009881.1 hypothetical protein 441742 5645147 A1C_02430 Rickettsia akari str. Hartford hypothetical protein YP_001493293.1 441362 D 293614 CDS YP_001493294.1 157825574 5645148 complement(441926..443269) 1 NC_009881.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 443269 gltX 5645148 gltX Rickettsia akari str. Hartford glutamyl-tRNA synthetase YP_001493294.1 441926 R 293614 CDS YP_001493295.1 157825575 5645149 complement(443524..445854) 1 NC_009881.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 445854 5645149 A1C_02440 Rickettsia akari str. Hartford DNA topoisomerase I YP_001493295.1 443524 R 293614 CDS YP_001493296.1 157825576 5645150 complement(445978..446172) 1 NC_009881.1 hypothetical protein 446172 5645150 A1C_02445 Rickettsia akari str. Hartford hypothetical protein YP_001493296.1 445978 R 293614 CDS YP_001493297.1 157825577 5645410 complement(446634..446957) 1 NC_009881.1 putative DNA processing protein DprA 446957 5645410 A1C_02450 Rickettsia akari str. Hartford putative DNA processing protein DprA YP_001493297.1 446634 R 293614 CDS YP_001493298.1 157825578 5645411 complement(447151..447753) 1 NC_009881.1 COG0450 Peroxiredoxin; thioredoxin peroxidase 1 447753 5645411 A1C_02455 Rickettsia akari str. Hartford thioredoxin peroxidase 1 YP_001493298.1 447151 R 293614 CDS YP_001493299.1 157825579 5645412 complement(447835..448770) 1 NC_009881.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs; membrane protease subunit stomatin/prohibitin-like protein 448770 5645412 A1C_02460 Rickettsia akari str. Hartford membrane protease subunit stomatin/prohibitin-like protein YP_001493299.1 447835 R 293614 CDS YP_001493300.1 157825580 5645413 complement(449549..451117) 1 NC_009881.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase; hypothetical protein 451117 5645413 A1C_02465 Rickettsia akari str. Hartford hypothetical protein YP_001493300.1 449549 R 293614 CDS YP_001493301.1 157825581 5645414 451193..451657 1 NC_009881.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 451657 5645414 A1C_02470 Rickettsia akari str. Hartford Holliday junction resolvase-like protein YP_001493301.1 451193 D 293614 CDS YP_001493302.1 157825582 5645415 451872..452057 1 NC_009881.1 COG3093 Plasmid maintenance system antidote protein; plasmid maintenance system antidote protein 452057 5645415 A1C_02475 Rickettsia akari str. Hartford plasmid maintenance system antidote protein YP_001493302.1 451872 D 293614 CDS YP_001493303.1 157825583 5645416 452296..453150 1 NC_009881.1 COG1091 dTDP-4-dehydrorhamnose reductase; dTDP-4-dehydrorhamnose reductase 453150 5645416 A1C_02480 Rickettsia akari str. Hartford dTDP-4-dehydrorhamnose reductase YP_001493303.1 452296 D 293614 CDS YP_001493304.1 157825584 5645868 453327..454352 1 NC_009881.1 COG1086 Predicted nucleoside-diphosphate sugar epimerases; CapD protein 454352 5645868 A1C_02485 Rickettsia akari str. Hartford CapD protein YP_001493304.1 453327 D 293614 CDS YP_001493305.1 157825585 5645869 454345..455604 1 NC_009881.1 COG0381 UDP-N-acetylglucosamine 2-epimerase; UDP-N-acetylglucosamine 2-epimerase 455604 5645869 A1C_02490 Rickettsia akari str. Hartford UDP-N-acetylglucosamine 2-epimerase YP_001493305.1 454345 D 293614 CDS YP_001493306.1 157825586 5645870 455633..456907 1 NC_009881.1 hypothetical protein 456907 5645870 A1C_02495 Rickettsia akari str. Hartford hypothetical protein YP_001493306.1 455633 D 293614 CDS YP_001493307.1 157825587 5645871 456926..457111 1 NC_009881.1 hypothetical protein 457111 5645871 A1C_02500 Rickettsia akari str. Hartford hypothetical protein YP_001493307.1 456926 D 293614 CDS YP_001493308.1 157825588 5645872 457124..457387 1 NC_009881.1 hypothetical protein 457387 5645872 A1C_02505 Rickettsia akari str. Hartford hypothetical protein YP_001493308.1 457124 D 293614 CDS YP_001493309.1 157825589 5645873 458015..459829 1 NC_009881.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; glycosyltransferase 459829 5645873 A1C_02510 Rickettsia akari str. Hartford glycosyltransferase YP_001493309.1 458015 D 293614 CDS YP_001493310.1 157825590 5645874 complement(460889..461656) 1 NC_009881.1 hypothetical protein 461656 5645874 A1C_02525 Rickettsia akari str. Hartford hypothetical protein YP_001493310.1 460889 R 293614 CDS YP_001493311.1 157825591 5644649 complement(461926..462687) 1 NC_009881.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); hypothetical protein 462687 5644649 A1C_02530 Rickettsia akari str. Hartford hypothetical protein YP_001493311.1 461926 R 293614 CDS YP_001493312.1 157825592 5644650 462720..463892 1 NC_009881.1 COG0438 Glycosyltransferase; glycosyltransferase 463892 5644650 A1C_02535 Rickettsia akari str. Hartford glycosyltransferase YP_001493312.1 462720 D 293614 CDS YP_001493313.1 157825593 5644651 complement(463954..464151) 1 NC_009881.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; ABC transporter ATP-binding protein 464151 5644651 A1C_02540 Rickettsia akari str. Hartford ABC transporter ATP-binding protein YP_001493313.1 463954 R 293614 CDS YP_001493314.1 157825594 5644652 complement(464313..464627) 1 NC_009881.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains; hypothetical protein 464627 5644652 A1C_02545 Rickettsia akari str. Hartford hypothetical protein YP_001493314.1 464313 R 293614 CDS YP_001493315.1 157825595 5644653 complement(464790..465086) 1 NC_009881.1 hypothetical protein 465086 5644653 A1C_02550 Rickettsia akari str. Hartford hypothetical protein YP_001493315.1 464790 R 293614 CDS YP_001493316.1 157825596 5644654 complement(465117..465290) 1 NC_009881.1 ABC transporter ATP-binding protein 465290 5644654 A1C_02555 Rickettsia akari str. Hartford ABC transporter ATP-binding protein YP_001493316.1 465117 R 293614 CDS YP_001493317.1 157825597 5644655 complement(465760..466026) 1 NC_009881.1 30S ribosomal protein S4 466026 rpsD 5644655 rpsD Rickettsia akari str. Hartford 30S ribosomal protein S4 YP_001493317.1 465760 R 293614 CDS YP_001493318.1 157825598 5645165 complement(466268..466885) 1 NC_009881.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 466885 rpsD 5645165 rpsD Rickettsia akari str. Hartford 30S ribosomal protein S4 YP_001493318.1 466268 R 293614 CDS YP_001493319.1 157825599 5645166 467004..467921 1 NC_009881.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 467921 5645166 A1C_02570 Rickettsia akari str. Hartford protoheme IX farnesyltransferase YP_001493319.1 467004 D 293614 CDS YP_001493320.1 157825600 5645167 complement(468248..468667) 1 NC_009881.1 COG1533 DNA repair photolyase; putative lyase 468667 5645167 A1C_02575 Rickettsia akari str. Hartford putative lyase YP_001493320.1 468248 R 293614 CDS YP_001493321.1 157825601 5645168 complement(468719..468847) 1 NC_009881.1 putative lyase 468847 5645168 A1C_02580 Rickettsia akari str. Hartford putative lyase YP_001493321.1 468719 R 293614 CDS YP_001493322.1 157825602 5645169 469091..469471 1 NC_009881.1 hypothetical protein 469471 5645169 A1C_02585 Rickettsia akari str. Hartford hypothetical protein YP_001493322.1 469091 D 293614 CDS YP_001493323.1 157825603 5645170 469453..469566 1 NC_009881.1 hypothetical protein 469566 5645170 A1C_02590 Rickettsia akari str. Hartford hypothetical protein YP_001493323.1 469453 D 293614 CDS YP_001493324.1 157825604 5645171 470014..470157 1 NC_009881.1 hypothetical protein 470157 5645171 A1C_02595 Rickettsia akari str. Hartford hypothetical protein YP_001493324.1 470014 D 293614 CDS YP_001493325.1 157825605 5645644 complement(470445..472937) 1 NC_009881.1 COG2982 Uncharacterized protein involved in outer membrane biogenesis; outer membrane assembly protein 472937 5645644 A1C_02600 Rickettsia akari str. Hartford outer membrane assembly protein YP_001493325.1 470445 R 293614 CDS YP_001493326.1 157825606 5645645 473317..473514 1 NC_009881.1 transposase 473514 5645645 A1C_02605 Rickettsia akari str. Hartford transposase YP_001493326.1 473317 D 293614 CDS YP_001493327.1 157825607 5645646 complement(473536..474033) 1 NC_009881.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 474033 rimM 5645646 rimM Rickettsia akari str. Hartford 16S rRNA-processing protein RimM YP_001493327.1 473536 R 293614 CDS YP_001493328.1 157825608 5645647 476738..476980 1 NC_009881.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 476980 5645647 A1C_02625 Rickettsia akari str. Hartford exodeoxyribonuclease VII small subunit YP_001493328.1 476738 D 293614 CDS YP_001493329.1 157825609 5645648 477518..477718 1 NC_009881.1 hypothetical protein 477718 5645648 A1C_02630 Rickettsia akari str. Hartford hypothetical protein YP_001493329.1 477518 D 293614 CDS YP_001493330.1 157825610 5645649 complement(478114..478488) 1 NC_009881.1 COG2094 3-methyladenine DNA glycosylase; 3-methyladenine DNA glycosylase 478488 5645649 A1C_02635 Rickettsia akari str. Hartford 3-methyladenine DNA glycosylase YP_001493330.1 478114 R 293614 CDS YP_001493331.1 157825611 5645650 complement(479020..479268) 1 NC_009881.1 COG0759 Uncharacterized conserved protein; hypothetical protein 479268 5645650 A1C_02640 Rickettsia akari str. Hartford hypothetical protein YP_001493331.1 479020 R 293614 CDS YP_001493332.1 157825612 5644977 complement(479261..479764) 1 NC_009881.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 479764 5644977 A1C_02645 Rickettsia akari str. Hartford NADH dehydrogenase subunit E YP_001493332.1 479261 R 293614 CDS YP_001493333.1 157825613 5644978 complement(479801..480985) 1 NC_009881.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 480985 5644978 A1C_02650 Rickettsia akari str. Hartford NADH dehydrogenase subunit D YP_001493333.1 479801 R 293614 CDS YP_001493334.1 157825614 5644979 complement(481064..481210) 1 NC_009881.1 COG2827 Predicted endonuclease containing a URI domain; endo/excinuclease amino terminal domain-containing protein 481210 5644979 A1C_02655 Rickettsia akari str. Hartford endo/excinuclease amino terminal domain-containing protein YP_001493334.1 481064 R 293614 CDS YP_001493335.1 157825615 5644980 complement(481210..481332) 1 NC_009881.1 COG2827 Predicted endonuclease containing a URI domain; NADH dehydrogenase subunit C 481332 5644980 A1C_02660 Rickettsia akari str. Hartford NADH dehydrogenase subunit C YP_001493335.1 481210 R 293614 CDS YP_001493336.1 157825616 5644981 complement(481414..482037) 1 NC_009881.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C 482037 5644981 A1C_02665 Rickettsia akari str. Hartford NADH dehydrogenase subunit C YP_001493336.1 481414 R 293614 CDS YP_001493337.1 157825617 5644982 complement(482015..482539) 1 NC_009881.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 482539 5644982 A1C_02670 Rickettsia akari str. Hartford NADH dehydrogenase subunit B YP_001493337.1 482015 R 293614 CDS YP_001493338.1 157825618 5644983 complement(482542..482913) 1 NC_009881.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 482913 5644983 A1C_02675 Rickettsia akari str. Hartford NADH dehydrogenase subunit A YP_001493338.1 482542 R 293614 CDS YP_001493339.1 157825619 5645249 complement(483013..484239) 1 NC_009881.1 COG3307 Lipid A core - O-antigen ligase and related enzymes; hypothetical protein 484239 5645249 A1C_02680 Rickettsia akari str. Hartford hypothetical protein YP_001493339.1 483013 R 293614 CDS YP_001493340.1 157825620 5645250 complement(484236..484718) 1 NC_009881.1 COG4765 Uncharacterized protein conserved in bacteria; hypothetical protein 484718 5645250 A1C_02685 Rickettsia akari str. Hartford hypothetical protein YP_001493340.1 484236 R 293614 CDS YP_001493341.1 157825621 5645251 484894..485184 1 NC_009881.1 COG5410 Uncharacterized protein conserved in bacteria; hypothetical protein 485184 5645251 A1C_02690 Rickettsia akari str. Hartford hypothetical protein YP_001493341.1 484894 D 293614 CDS YP_001493342.1 157825622 5645252 485337..485435 1 NC_009881.1 hypothetical protein 485435 5645252 A1C_02695 Rickettsia akari str. Hartford hypothetical protein YP_001493342.1 485337 D 293614 CDS YP_001493343.1 157825623 5645253 485768..485920 1 NC_009881.1 hypothetical protein 485920 5645253 A1C_02700 Rickettsia akari str. Hartford hypothetical protein YP_001493343.1 485768 D 293614 CDS YP_001493344.1 157825624 5645255 486550..487470 1 NC_009881.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 487470 xerD 5645255 xerD Rickettsia akari str. Hartford site-specific tyrosine recombinase XerD YP_001493344.1 486550 D 293614 CDS YP_001493345.1 157825625 5645518 487553..488614 1 NC_009881.1 hypothetical protein 488614 5645518 A1C_02710 Rickettsia akari str. Hartford hypothetical protein YP_001493345.1 487553 D 293614 CDS YP_001493346.1 157825626 5645519 488726..489889 1 NC_009881.1 hypothetical protein 489889 5645519 A1C_02715 Rickettsia akari str. Hartford hypothetical protein YP_001493346.1 488726 D 293614 CDS YP_001493347.1 157825627 5645520 complement(490076..490858) 1 NC_009881.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 490858 5645520 A1C_02720 Rickettsia akari str. Hartford enoyl-(acyl carrier protein) reductase YP_001493347.1 490076 R 293614 CDS YP_001493348.1 157825628 5645521 490941..492431 1 NC_009881.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 492431 lnt 5645521 lnt Rickettsia akari str. Hartford apolipoprotein N-acyltransferase YP_001493348.1 490941 D 293614 CDS YP_001493349.1 157825629 5645522 494104..495021 1 NC_009881.1 COG2984 ABC-type uncharacterized transport system, periplasmic component; hypothetical protein 495021 5645522 A1C_02730 Rickettsia akari str. Hartford hypothetical protein YP_001493349.1 494104 D 293614 CDS YP_001493350.1 157825630 5645523 495026..495859 1 NC_009881.1 COG4120 ABC-type uncharacterized transport system, permease component; ABC transporter permease 495859 5645523 A1C_02735 Rickettsia akari str. Hartford ABC transporter permease YP_001493350.1 495026 D 293614 CDS YP_001493351.1 157825631 5645730 495976..496719 1 NC_009881.1 COG1101 ABC-type uncharacterized transport system, ATPase component; putative ABC transporter ATP-binding protein 496719 5645730 A1C_02740 Rickettsia akari str. Hartford putative ABC transporter ATP-binding protein YP_001493351.1 495976 D 293614 CDS YP_001493352.1 157825632 5645731 complement(496721..497020) 1 NC_009881.1 transposase IS982 497020 5645731 A1C_02745 Rickettsia akari str. Hartford transposase IS982 YP_001493352.1 496721 R 293614 CDS YP_001493353.1 157825633 5645732 complement(497779..498294) 1 NC_009881.1 COG1495 Disulfide bond formation protein DsbB; hypothetical protein 498294 5645732 A1C_02750 Rickettsia akari str. Hartford hypothetical protein YP_001493353.1 497779 R 293614 CDS YP_001493354.1 157825634 5645733 498497..500086 1 NC_009881.1 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine; lysyl-tRNA synthetase 500086 lysK 5645733 lysK Rickettsia akari str. Hartford lysyl-tRNA synthetase YP_001493354.1 498497 D 293614 CDS YP_001493355.1 157825635 5645734 500147..501079 1 NC_009881.1 COG0679 Predicted permeases; permease 501079 5645734 A1C_02760 Rickettsia akari str. Hartford permease YP_001493355.1 500147 D 293614 CDS YP_001493356.1 157825636 5645735 501203..503506 1 NC_009881.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 503506 5645735 A1C_02765 Rickettsia akari str. Hartford malic enzyme YP_001493356.1 501203 D 293614 CDS YP_001493357.1 157825637 5645736 503767..505716 1 NC_009881.1 COG5307 SEC7 domain proteins; hypothetical protein 505716 5645736 A1C_02770 Rickettsia akari str. Hartford hypothetical protein YP_001493357.1 503767 D 293614 CDS YP_001493358.1 157825638 5644883 506001..506198 1 NC_009881.1 COG1943 Transposase and inactivated derivatives; transposase IS200-family protein 506198 5644883 A1C_02775 Rickettsia akari str. Hartford transposase IS200-family protein YP_001493358.1 506001 D 293614 CDS YP_001493359.1 157825639 5644884 complement(506229..506444) 1 NC_009881.1 COG4374 Uncharacterized protein conserved in bacteria; hypothetical protein 506444 5644884 A1C_02780 Rickettsia akari str. Hartford hypothetical protein YP_001493359.1 506229 R 293614 CDS YP_001493360.1 157825640 5644885 complement(506437..506568) 1 NC_009881.1 hypothetical protein 506568 5644885 A1C_02785 Rickettsia akari str. Hartford hypothetical protein YP_001493360.1 506437 R 293614 CDS YP_001493361.1 157825641 5644886 complement(506561..506857) 1 NC_009881.1 hypothetical protein 506857 5644886 A1C_02790 Rickettsia akari str. Hartford hypothetical protein YP_001493361.1 506561 R 293614 CDS YP_001493362.1 157825642 5644887 506954..508285 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; proline/betaine transporter 508285 5644887 A1C_02795 Rickettsia akari str. Hartford proline/betaine transporter YP_001493362.1 506954 D 293614 CDS YP_001493363.1 157825643 5644888 complement(508784..509023) 1 NC_009881.1 hypothetical protein 509023 5644888 A1C_02800 Rickettsia akari str. Hartford hypothetical protein YP_001493363.1 508784 R 293614 CDS YP_001493364.1 157825644 5644889 complement(509120..509302) 1 NC_009881.1 hypothetical protein 509302 5644889 A1C_02805 Rickettsia akari str. Hartford hypothetical protein YP_001493364.1 509120 R 293614 CDS YP_001493365.1 157825645 5644635 complement(511645..512589) 1 NC_009881.1 Catalyzes the reversible oxidation of malate to oxaloacetate; malate dehydrogenase 512589 5644635 A1C_02825 Rickettsia akari str. Hartford malate dehydrogenase YP_001493365.1 511645 R 293614 CDS YP_001493366.1 157825646 5644636 complement(513830..515353) 1 NC_009881.1 COG3202 ATP/ADP translocase; ADP,ATP carrier protein 515353 5644636 A1C_02830 Rickettsia akari str. Hartford ADP,ATP carrier protein YP_001493366.1 513830 R 293614 CDS YP_001493367.1 157825647 5644637 complement(515287..515460) 1 NC_009881.1 CTP synthetase 515460 5644637 A1C_02835 Rickettsia akari str. Hartford CTP synthetase YP_001493367.1 515287 R 293614 CDS YP_001493368.1 157825648 5644638 516093..516260 1 NC_009881.1 CTP synthetase 516260 5644638 A1C_02845 Rickettsia akari str. Hartford CTP synthetase YP_001493368.1 516093 D 293614 CDS YP_001493369.1 157825649 5644639 complement(517215..517955) 1 NC_009881.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 517955 5644639 A1C_02855 Rickettsia akari str. Hartford 3-deoxy-manno-octulosonate cytidylyltransferase YP_001493369.1 517215 R 293614 CDS YP_001493370.1 157825650 5645825 complement(518463..518666) 1 NC_009881.1 COG1051 ADP-ribose pyrophosphatase; ADP-ribose pyrophosphatase MutT 518666 5645825 A1C_02860 Rickettsia akari str. Hartford ADP-ribose pyrophosphatase MutT YP_001493370.1 518463 R 293614 CDS YP_001493371.1 157825651 5645826 518880..520430 1 NC_009881.1 hypothetical protein 520430 5645826 A1C_02865 Rickettsia akari str. Hartford hypothetical protein YP_001493371.1 518880 D 293614 CDS YP_001493372.1 157825652 5645827 520423..520995 1 NC_009881.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 520995 folE 5645827 folE Rickettsia akari str. Hartford GTP cyclohydrolase I YP_001493372.1 520423 D 293614 CDS YP_001493373.1 157825653 5645828 521006..522289 1 NC_009881.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 522289 5645828 A1C_02875 Rickettsia akari str. Hartford prolyl-tRNA synthetase YP_001493373.1 521006 D 293614 CDS YP_001493374.1 157825654 5645829 522339..522566 1 NC_009881.1 antitoxin of toxin-antitoxin system StbD 522566 5645829 A1C_02880 Rickettsia akari str. Hartford antitoxin of toxin-antitoxin system StbD YP_001493374.1 522339 D 293614 CDS YP_001493375.1 157825655 5645775 522566..522670 1 NC_009881.1 hypothetical protein 522670 5645775 A1C_02885 Rickettsia akari str. Hartford hypothetical protein YP_001493375.1 522566 D 293614 CDS YP_001493376.1 157825656 5645776 522907..523122 1 NC_009881.1 hypothetical protein 523122 5645776 A1C_02890 Rickettsia akari str. Hartford hypothetical protein YP_001493376.1 522907 D 293614 CDS YP_001493377.1 157825657 5645777 523128..523739 1 NC_009881.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 523739 ruvA 5645777 ruvA Rickettsia akari str. Hartford Holliday junction DNA helicase RuvA YP_001493377.1 523128 D 293614 CDS YP_001493378.1 157825658 5645778 523726..523860 1 NC_009881.1 hypothetical protein 523860 5645778 A1C_02900 Rickettsia akari str. Hartford hypothetical protein YP_001493378.1 523726 D 293614 CDS YP_001493379.1 157825659 5645779 524058..524276 1 NC_009881.1 hypothetical protein 524276 5645779 A1C_02905 Rickettsia akari str. Hartford hypothetical protein YP_001493379.1 524058 D 293614 CDS YP_001493380.1 157825660 5645780 524339..525367 1 NC_009881.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 525367 ruvB 5645780 ruvB Rickettsia akari str. Hartford Holliday junction DNA helicase RuvB YP_001493380.1 524339 D 293614 CDS YP_001493381.1 157825661 5645781 525360..527123 1 NC_009881.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; multidrug resistance protein 527123 5645781 A1C_02915 Rickettsia akari str. Hartford multidrug resistance protein YP_001493381.1 525360 D 293614 CDS YP_001493382.1 157825662 5645782 527474..528718 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; AmpG protein 528718 5645782 A1C_02920 Rickettsia akari str. Hartford AmpG protein YP_001493382.1 527474 D 293614 CDS YP_001493383.1 157825663 5645082 528910..529830 1 NC_009881.1 COG1686 D-alanyl-D-alanine carboxypeptidase; penicillin-binding protein dacF 529830 5645082 A1C_02925 Rickettsia akari str. Hartford penicillin-binding protein dacF YP_001493383.1 528910 D 293614 CDS YP_001493384.1 157825664 5645083 complement(530156..530854) 1 NC_009881.1 COG0797 Lipoproteins; rare lipoprotein A 530854 5645083 A1C_02930 Rickettsia akari str. Hartford rare lipoprotein A YP_001493384.1 530156 R 293614 CDS YP_001493385.1 157825665 5645084 complement(530832..531446) 1 NC_009881.1 COG2823 Predicted periplasmic or secreted lipoprotein; hypothetical protein 531446 5645084 A1C_02935 Rickettsia akari str. Hartford hypothetical protein YP_001493385.1 530832 R 293614 CDS YP_001493386.1 157825666 5645085 complement(531856..532398) 1 NC_009881.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 532398 5645085 A1C_02940 Rickettsia akari str. Hartford intracellular septation protein A YP_001493386.1 531856 R 293614 CDS YP_001493387.1 157825667 5645086 complement(532428..533276) 1 NC_009881.1 COG0672 High-affinity Fe2+/Pb2+ permease; FTR1 family protein 533276 5645086 A1C_02945 Rickettsia akari str. Hartford FTR1 family protein YP_001493387.1 532428 R 293614 CDS YP_001493388.1 157825668 5645087 complement(533286..533666) 1 NC_009881.1 hypothetical protein 533666 5645087 A1C_02950 Rickettsia akari str. Hartford hypothetical protein YP_001493388.1 533286 R 293614 CDS YP_001493389.1 157825669 5645088 complement(533775..533888) 1 NC_009881.1 hypothetical protein 533888 5645088 A1C_02955 Rickettsia akari str. Hartford hypothetical protein YP_001493389.1 533775 R 293614 CDS YP_001493390.1 157825670 5645380 complement(533895..534890) 1 NC_009881.1 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2; hypothetical protein 534890 5645380 A1C_02960 Rickettsia akari str. Hartford hypothetical protein YP_001493390.1 533895 R 293614 CDS YP_001493391.1 157825671 5645381 535202..535828 1 NC_009881.1 COG3485 Protocatechuate 3,4-dioxygenase beta subunit; protocatechuate-3,4-dioxygenase subunit beta 535828 5645381 A1C_02965 Rickettsia akari str. Hartford protocatechuate-3,4-dioxygenase subunit beta YP_001493391.1 535202 D 293614 CDS YP_001493392.1 157825672 5645382 536003..536668 1 NC_009881.1 COG0526 Thiol-disulfide isomerase and thioredoxins; thiol:disulfide interchange protein tlpA 536668 5645382 A1C_02970 Rickettsia akari str. Hartford thiol:disulfide interchange protein tlpA YP_001493392.1 536003 D 293614 CDS YP_001493393.1 157825673 5645383 536661..537575 1 NC_009881.1 COG0616 Periplasmic serine proteases (ClpP class); signal peptide peptidase SppA 537575 5645383 A1C_02975 Rickettsia akari str. Hartford signal peptide peptidase SppA YP_001493393.1 536661 D 293614 CDS YP_001493394.1 157825674 5645384 537731..538177 1 NC_009881.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 538177 dut 5645384 dut Rickettsia akari str. Hartford deoxyuridine 5'-triphosphate nucleotidohydrolase YP_001493394.1 537731 D 293614 CDS YP_001493395.1 157825675 5645385 538373..540370 1 NC_009881.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); soluble lytic murein transglycosylase precursor 540370 5645385 A1C_02985 Rickettsia akari str. Hartford soluble lytic murein transglycosylase precursor YP_001493395.1 538373 D 293614 CDS YP_001493396.1 157825676 5645386 540450..541631 1 NC_009881.1 hypothetical protein 541631 5645386 A1C_02990 Rickettsia akari str. Hartford hypothetical protein YP_001493396.1 540450 D 293614 CDS YP_001493397.1 157825677 5645103 541716..542669 1 NC_009881.1 COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF; microcin C7 self-immunity protein 542669 5645103 A1C_02995 Rickettsia akari str. Hartford microcin C7 self-immunity protein YP_001493397.1 541716 D 293614 CDS YP_001493398.1 157825678 5645104 complement(542770..545436) 1 NC_009881.1 COG2887 RecB family exonuclease; hypothetical protein 545436 5645104 A1C_03000 Rickettsia akari str. Hartford hypothetical protein YP_001493398.1 542770 R 293614 CDS YP_001493399.1 157825679 5645105 545541..545924 1 NC_009881.1 hypothetical protein 545924 5645105 A1C_03005 Rickettsia akari str. Hartford hypothetical protein YP_001493399.1 545541 D 293614 CDS YP_001493400.1 157825680 5645106 complement(545982..546710) 1 NC_009881.1 COG2071 Predicted glutamine amidotransferases; hypothetical protein 546710 5645106 A1C_03010 Rickettsia akari str. Hartford hypothetical protein YP_001493400.1 545982 R 293614 CDS YP_001493401.1 157825681 5645107 complement(546881..548503) 1 NC_009881.1 COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1; cytochrome c oxidase polypeptide I 548503 5645107 A1C_03015 Rickettsia akari str. Hartford cytochrome c oxidase polypeptide I YP_001493401.1 546881 R 293614 CDS YP_001493402.1 157825682 5645108 complement(549021..549203) 1 NC_009881.1 hypothetical protein 549203 5645108 A1C_03020 Rickettsia akari str. Hartford hypothetical protein YP_001493402.1 549021 R 293614 CDS YP_001493403.1 157825683 5645109 complement(549200..549334) 1 NC_009881.1 hypothetical protein 549334 5645109 A1C_03025 Rickettsia akari str. Hartford hypothetical protein YP_001493403.1 549200 R 293614 CDS YP_001493404.1 157825684 5645277 complement(549578..550519) 1 NC_009881.1 COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2; cytochrome c oxidase polypeptide II 550519 5645277 A1C_03030 Rickettsia akari str. Hartford cytochrome c oxidase polypeptide II YP_001493404.1 549578 R 293614 CDS YP_001493405.1 157825685 5645278 551338..552672 1 NC_009881.1 COG0739 Membrane proteins related to metalloendopeptidases; hypothetical protein 552672 5645278 A1C_03035 Rickettsia akari str. Hartford hypothetical protein YP_001493405.1 551338 D 293614 CDS YP_001493406.1 157825686 5645279 552987..553577 1 NC_009881.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 553577 lspA 5645279 lspA Rickettsia akari str. Hartford lipoprotein signal peptidase YP_001493406.1 552987 D 293614 CDS YP_001493407.1 157825687 5645280 553598..553846 1 NC_009881.1 hypothetical protein 553846 5645280 A1C_03045 Rickettsia akari str. Hartford hypothetical protein YP_001493407.1 553598 D 293614 CDS YP_001493408.1 157825688 5645281 553916..555394 1 NC_009881.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 555394 murD 5645281 murD Rickettsia akari str. Hartford UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_001493408.1 553916 D 293614 CDS YP_001493409.1 157825689 5645282 555649..556782 1 NC_009881.1 COG0772 Bacterial cell division membrane protein; cell division protein FtsW 556782 5645282 A1C_03055 Rickettsia akari str. Hartford cell division protein FtsW YP_001493409.1 555649 D 293614 CDS YP_001493410.1 157825690 5645283 556779..557927 1 NC_009881.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 557927 murG 5645283 murG Rickettsia akari str. Hartford undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_001493410.1 556779 D 293614 CDS YP_001493411.1 157825691 5645060 558128..558784 1 NC_009881.1 hypothetical protein 558784 5645060 A1C_03065 Rickettsia akari str. Hartford hypothetical protein YP_001493411.1 558128 D 293614 CDS YP_001493412.1 157825692 5645061 559101..559313 1 NC_009881.1 hypothetical protein 559313 5645061 A1C_03070 Rickettsia akari str. Hartford hypothetical protein YP_001493412.1 559101 D 293614 CDS YP_001493413.1 157825693 5645062 complement(561574..561978) 1 NC_009881.1 COG0841 Cation/multidrug efflux pump; RND family efflux transporter 561978 5645062 A1C_03095 Rickettsia akari str. Hartford RND family efflux transporter YP_001493413.1 561574 R 293614 CDS YP_001493414.1 157825694 5645063 complement(562465..562566) 1 NC_009881.1 RND family transporter membrane-fusion protein 562566 5645063 A1C_03100 Rickettsia akari str. Hartford RND family transporter membrane-fusion protein YP_001493414.1 562465 R 293614 CDS YP_001493415.1 157825695 5645064 complement(562920..563213) 1 NC_009881.1 COG0845 Membrane-fusion protein; RND family transporter membrane-fusion protein 563213 5645064 A1C_03105 Rickettsia akari str. Hartford RND family transporter membrane-fusion protein YP_001493415.1 562920 R 293614 CDS YP_001493416.1 157825696 5645065 complement(563292..563489) 1 NC_009881.1 COG0845 Membrane-fusion protein; RND family transporter membrane-fusion protein 563489 5645065 A1C_03110 Rickettsia akari str. Hartford RND family transporter membrane-fusion protein YP_001493416.1 563292 R 293614 CDS YP_001493417.1 157825697 5645066 complement(563672..564052) 1 NC_009881.1 COG1538 Outer membrane protein; hypothetical protein 564052 5645066 A1C_03115 Rickettsia akari str. Hartford hypothetical protein YP_001493417.1 563672 R 293614 CDS YP_001493418.1 157825698 5644905 complement(564528..565550) 1 NC_009881.1 COG0438 Glycosyltransferase; glycosyltransferase 565550 5644905 A1C_03120 Rickettsia akari str. Hartford glycosyltransferase YP_001493418.1 564528 R 293614 CDS YP_001493419.1 157825699 5644906 complement(565695..566087) 1 NC_009881.1 hypothetical protein 566087 5644906 A1C_03125 Rickettsia akari str. Hartford hypothetical protein YP_001493419.1 565695 R 293614 CDS YP_001493420.1 157825700 5644907 566521..567333 1 NC_009881.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 567333 dapF 5644907 dapF Rickettsia akari str. Hartford diaminopimelate epimerase YP_001493420.1 566521 D 293614 CDS YP_001493421.1 157825701 5644908 567323..568573 1 NC_009881.1 COG0621 2-methylthioadenine synthetase; MiaB-like tRNA modifying enzyme 568573 5644908 A1C_03135 Rickettsia akari str. Hartford MiaB-like tRNA modifying enzyme YP_001493421.1 567323 D 293614 CDS YP_001493422.1 157825702 5644909 568674..569723 1 NC_009881.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 569723 pheS 5644909 pheS Rickettsia akari str. Hartford phenylalanyl-tRNA synthetase subunit alpha YP_001493422.1 568674 D 293614 CDS YP_001493423.1 157825703 5644910 569720..572116 1 NC_009881.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 572116 pheT 5644910 pheT Rickettsia akari str. Hartford phenylalanyl-tRNA synthetase subunit beta YP_001493423.1 569720 D 293614 CDS YP_001493424.1 157825704 5644911 572240..573379 1 NC_009881.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 573379 5644911 A1C_03150 Rickettsia akari str. Hartford DNA polymerase III subunit beta YP_001493424.1 572240 D 293614 CDS YP_001493425.1 157825705 5644802 573670..574173 1 NC_009881.1 hypothetical protein 574173 5644802 A1C_03155 Rickettsia akari str. Hartford hypothetical protein YP_001493425.1 573670 D 293614 CDS YP_001493426.1 157825706 5644803 574288..576900 1 NC_009881.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 576900 leuS 5644803 leuS Rickettsia akari str. Hartford leucyl-tRNA synthetase YP_001493426.1 574288 D 293614 CDS YP_001493427.1 157825707 5644804 complement(577294..577905) 1 NC_009881.1 COG0349 Ribonuclease D; ribonuclease D 577905 5644804 A1C_03165 Rickettsia akari str. Hartford ribonuclease D YP_001493427.1 577294 R 293614 CDS YP_001493428.1 157825708 5644805 complement(578038..578361) 1 NC_009881.1 COG2919 Septum formation initiator; hypothetical protein 578361 5644805 A1C_03170 Rickettsia akari str. Hartford hypothetical protein YP_001493428.1 578038 R 293614 CDS YP_001493429.1 157825709 5644806 complement(578358..579038) 1 NC_009881.1 COG0575 CDP-diglyceride synthetase; phosphatidate cytidylyltransferase 579038 5644806 A1C_03175 Rickettsia akari str. Hartford phosphatidate cytidylyltransferase YP_001493429.1 578358 R 293614 CDS YP_001493430.1 157825710 5644807 complement(578998..579678) 1 NC_009881.1 COG0020 Undecaprenyl pyrophosphate synthase; undecaprenyl pyrophosphate synthetase 579678 5644807 A1C_03180 Rickettsia akari str. Hartford undecaprenyl pyrophosphate synthetase YP_001493430.1 578998 R 293614 CDS YP_001493431.1 157825711 5644808 complement(579911..581173) 1 NC_009881.1 COG0642 Signal transduction histidine kinase; osmolarity sensor protein EnvZ 581173 5644808 A1C_03185 Rickettsia akari str. Hartford osmolarity sensor protein EnvZ YP_001493431.1 579911 R 293614 CDS YP_001493432.1 157825712 5645629 complement(581314..581994) 1 NC_009881.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; PetR protein 581994 5645629 A1C_03190 Rickettsia akari str. Hartford PetR protein YP_001493432.1 581314 R 293614 CDS YP_001493433.1 157825713 5645630 582134..583006 1 NC_009881.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 583006 5645630 A1C_03195 Rickettsia akari str. Hartford branched-chain amino acid aminotransferase YP_001493433.1 582134 D 293614 CDS YP_001493434.1 157825714 5645631 583124..584008 1 NC_009881.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 584008 5645631 A1C_03200 Rickettsia akari str. Hartford dihydrodipicolinate synthase YP_001493434.1 583124 D 293614 CDS YP_001493435.1 157825715 5645632 584005..584463 1 NC_009881.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 584463 smpB 5645632 smpB Rickettsia akari str. Hartford SsrA-binding protein YP_001493435.1 584005 D 293614 CDS YP_001493436.1 157825716 5645633 584629..585423 1 NC_009881.1 COG1651 Protein-disulfide isomerase; Thiol:disulfide interchange protein DsbA 585423 5645633 A1C_03210 Rickettsia akari str. Hartford Thiol:disulfide interchange protein DsbA YP_001493436.1 584629 D 293614 CDS YP_001493437.1 157825717 5645634 complement(585801..586679) 1 NC_009881.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 586679 5645634 A1C_03215 Rickettsia akari str. Hartford succinyl-CoA synthetase subunit alpha YP_001493437.1 585801 R 293614 CDS YP_001493438.1 157825718 5645635 complement(586842..588002) 1 NC_009881.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 588002 sucC 5645635 sucC Rickettsia akari str. Hartford succinyl-CoA synthetase subunit beta YP_001493438.1 586842 R 293614 CDS YP_001493439.1 157825719 5645223 complement(588222..588461) 1 NC_009881.1 hypothetical protein 588461 5645223 A1C_03225 Rickettsia akari str. Hartford hypothetical protein YP_001493439.1 588222 R 293614 CDS YP_001493440.1 157825720 5645224 complement(588753..590789) 1 NC_009881.1 COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases; acylamino-acid-releasing protein 590789 5645224 A1C_03230 Rickettsia akari str. Hartford acylamino-acid-releasing protein YP_001493440.1 588753 R 293614 CDS YP_001493441.1 157825721 5645225 complement(590878..591513) 1 NC_009881.1 COG4395 Uncharacterized protein conserved in bacteria; hypothetical protein 591513 5645225 A1C_03235 Rickettsia akari str. Hartford hypothetical protein YP_001493441.1 590878 R 293614 CDS YP_001493442.1 157825722 5645226 complement(591815..592204) 1 NC_009881.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 592204 rbfA 5645226 rbfA Rickettsia akari str. Hartford ribosome-binding factor A YP_001493442.1 591815 R 293614 CDS YP_001493443.1 157825723 5645227 complement(592208..592633) 1 NC_009881.1 COG1238 Predicted membrane protein; hypothetical protein 592633 5645227 A1C_03245 Rickettsia akari str. Hartford hypothetical protein YP_001493443.1 592208 R 293614 CDS YP_001493444.1 157825724 5645228 592768..593289 1 NC_009881.1 COG1714 Predicted membrane protein/domain; hypothetical protein 593289 5645228 A1C_03250 Rickettsia akari str. Hartford hypothetical protein YP_001493444.1 592768 D 293614 CDS YP_001493445.1 157825725 5645229 593442..594065 1 NC_009881.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 594065 recR 5645229 recR Rickettsia akari str. Hartford recombination protein RecR YP_001493445.1 593442 D 293614 CDS YP_001493446.1 157825726 5644773 594276..594626 1 NC_009881.1 COG3023 Negative regulator of beta-lactamase expression; hypothetical protein 594626 5644773 A1C_03260 Rickettsia akari str. Hartford hypothetical protein YP_001493446.1 594276 D 293614 CDS YP_001493447.1 157825727 5644774 594825..594908 1 NC_009881.1 hypothetical protein 594908 5644774 A1C_03265 Rickettsia akari str. Hartford hypothetical protein YP_001493447.1 594825 D 293614 CDS YP_001493448.1 157825728 5644775 complement(595074..595514) 1 NC_009881.1 hypothetical protein 595514 5644775 A1C_03270 Rickettsia akari str. Hartford hypothetical protein YP_001493448.1 595074 R 293614 CDS YP_001493449.1 157825729 5644776 complement(595676..595840) 1 NC_009881.1 hypothetical protein 595840 5644776 A1C_03275 Rickettsia akari str. Hartford hypothetical protein YP_001493449.1 595676 R 293614 CDS YP_001493450.1 157825730 5644777 complement(595833..596078) 1 NC_009881.1 hypothetical protein 596078 5644777 A1C_03280 Rickettsia akari str. Hartford hypothetical protein YP_001493450.1 595833 R 293614 CDS YP_001493451.1 157825731 5644778 complement(596305..596457) 1 NC_009881.1 hypothetical protein 596457 5644778 A1C_03285 Rickettsia akari str. Hartford hypothetical protein YP_001493451.1 596305 R 293614 CDS YP_001493452.1 157825732 5644779 complement(596717..596920) 1 NC_009881.1 hypothetical protein 596920 5644779 A1C_03290 Rickettsia akari str. Hartford hypothetical protein YP_001493452.1 596717 R 293614 CDS YP_001493453.1 157825733 5644699 complement(597001..597768) 1 NC_009881.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 597768 ppnK 5644699 ppnK Rickettsia akari str. Hartford inorganic polyphosphate/ATP-NAD kinase YP_001493453.1 597001 R 293614 CDS YP_001493454.1 157825734 5644700 597855..599537 1 NC_009881.1 COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily; hypothetical protein 599537 5644700 A1C_03300 Rickettsia akari str. Hartford hypothetical protein YP_001493454.1 597855 D 293614 CDS YP_001493455.1 157825735 5644701 599616..599834 1 NC_009881.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 599834 gpsA 5644701 gpsA Rickettsia akari str. Hartford NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_001493455.1 599616 D 293614 CDS YP_001493456.1 157825736 5644702 599827..600780 1 NC_009881.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 600780 gpsA 5644702 gpsA Rickettsia akari str. Hartford NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_001493456.1 599827 D 293614 CDS YP_001493457.1 157825737 5644703 601037..601210 1 NC_009881.1 hypothetical protein 601210 5644703 A1C_03315 Rickettsia akari str. Hartford hypothetical protein YP_001493457.1 601037 D 293614 CDS YP_001493458.1 157825738 5644704 complement(601203..601373) 1 NC_009881.1 hypothetical protein 601373 5644704 A1C_03320 Rickettsia akari str. Hartford hypothetical protein YP_001493458.1 601203 R 293614 CDS YP_001493459.1 157825739 5644705 601682..602611 1 NC_009881.1 COG0679 Predicted permeases; permease 602611 5644705 A1C_03325 Rickettsia akari str. Hartford permease YP_001493459.1 601682 D 293614 CDS YP_001493460.1 157825740 5645708 602670..603542 1 NC_009881.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); hypothetical protein 603542 5645708 A1C_03330 Rickettsia akari str. Hartford hypothetical protein YP_001493460.1 602670 D 293614 CDS YP_001493461.1 157825741 5645709 603763..604695 1 NC_009881.1 COG0492 Thioredoxin reductase; thioredoxin reductase 604695 5645709 A1C_03335 Rickettsia akari str. Hartford thioredoxin reductase YP_001493461.1 603763 D 293614 CDS YP_001493462.1 157825742 5645710 604809..605024 1 NC_009881.1 hypothetical protein 605024 5645710 A1C_03340 Rickettsia akari str. Hartford hypothetical protein YP_001493462.1 604809 D 293614 CDS YP_001493463.1 157825743 5645711 605041..605337 1 NC_009881.1 hypothetical protein 605337 5645711 A1C_03345 Rickettsia akari str. Hartford hypothetical protein YP_001493463.1 605041 D 293614 CDS YP_001493464.1 157825744 5645712 605364..605576 1 NC_009881.1 hypothetical protein 605576 5645712 A1C_03350 Rickettsia akari str. Hartford hypothetical protein YP_001493464.1 605364 D 293614 CDS YP_001493465.1 157825745 5645713 605665..606000 1 NC_009881.1 COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain; hypothetical protein 606000 5645713 A1C_03355 Rickettsia akari str. Hartford hypothetical protein YP_001493465.1 605665 D 293614 CDS YP_001493466.1 157825746 5645714 606034..606150 1 NC_009881.1 hypothetical protein 606150 5645714 A1C_03360 Rickettsia akari str. Hartford hypothetical protein YP_001493466.1 606034 D 293614 CDS YP_001493467.1 157825747 5645006 606637..606834 1 NC_009881.1 COG1943 Transposase and inactivated derivatives; transposase IS200-family protein 606834 5645006 A1C_03365 Rickettsia akari str. Hartford transposase IS200-family protein YP_001493467.1 606637 D 293614 CDS YP_001493468.1 157825748 5645007 607132..608568 1 NC_009881.1 COG1012 NAD-dependent aldehyde dehydrogenases; succinate semialdehyde dehydrogenase 608568 5645007 A1C_03370 Rickettsia akari str. Hartford succinate semialdehyde dehydrogenase YP_001493468.1 607132 D 293614 CDS YP_001493469.1 157825749 5645008 608684..609097 1 NC_009881.1 hypothetical protein 609097 5645008 A1C_03375 Rickettsia akari str. Hartford hypothetical protein YP_001493469.1 608684 D 293614 CDS YP_001493470.1 157825750 5645009 609097..609942 1 NC_009881.1 COG0463 Glycosyltransferases involved in cell wall biogenesis; glycosyltransferase 609942 5645009 A1C_03380 Rickettsia akari str. Hartford glycosyltransferase YP_001493470.1 609097 D 293614 CDS YP_001493471.1 157825751 5645010 610162..612123 1 NC_009881.1 COG0210 Superfamily I DNA and RNA helicases; DNA helicase II 612123 5645010 A1C_03385 Rickettsia akari str. Hartford DNA helicase II YP_001493471.1 610162 D 293614 CDS YP_001493472.1 157825752 5645011 612214..612720 1 NC_009881.1 hypothetical protein 612720 5645011 A1C_03390 Rickettsia akari str. Hartford hypothetical protein YP_001493472.1 612214 D 293614 CDS YP_001493473.1 157825753 5645012 612795..613064 1 NC_009881.1 hypothetical protein 613064 5645012 A1C_03395 Rickettsia akari str. Hartford hypothetical protein YP_001493473.1 612795 D 293614 CDS YP_001493474.1 157825754 5644597 613253..613501 1 NC_009881.1 hypothetical protein 613501 5644597 A1C_03400 Rickettsia akari str. Hartford hypothetical protein YP_001493474.1 613253 D 293614 CDS YP_001493475.1 157825755 5644598 613556..614923 1 NC_009881.1 hypothetical protein 614923 5644598 A1C_03405 Rickettsia akari str. Hartford hypothetical protein YP_001493475.1 613556 D 293614 CDS YP_001493476.1 157825756 5644599 complement(615269..616270) 1 NC_009881.1 catalyzes the formation of 2-oxobutanoate from L-threonine; threonine dehydratase 616270 5644599 A1C_03410 Rickettsia akari str. Hartford threonine dehydratase YP_001493476.1 615269 R 293614 CDS YP_001493477.1 157825757 5644600 616356..618692 1 NC_009881.1 COG0466 ATP-dependent Lon protease, bacterial type; ATP-dependent protease La 618692 5644600 A1C_03415 Rickettsia akari str. Hartford ATP-dependent protease La YP_001493477.1 616356 D 293614 CDS YP_001493478.1 157825758 5644601 complement(618712..618897) 1 NC_009881.1 hypothetical protein 618897 5644601 A1C_03420 Rickettsia akari str. Hartford hypothetical protein YP_001493478.1 618712 R 293614 CDS YP_001493479.1 157825759 5644602 complement(620393..620494) 1 NC_009881.1 hypothetical protein 620494 5644602 A1C_03435 Rickettsia akari str. Hartford hypothetical protein YP_001493479.1 620393 R 293614 CDS YP_001493480.1 157825760 5645467 621392..621610 1 NC_009881.1 hypothetical protein 621610 5645467 A1C_03440 Rickettsia akari str. Hartford hypothetical protein YP_001493480.1 621392 D 293614 CDS YP_001493481.1 157825761 5645468 621809..622387 1 NC_009881.1 COG1544 Ribosome-associated protein Y (PSrp-1); sigma(54) modulation protein 622387 5645468 A1C_03445 Rickettsia akari str. Hartford sigma(54) modulation protein YP_001493481.1 621809 D 293614 CDS YP_001493482.1 157825762 5645469 622387..622545 1 NC_009881.1 COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily; carbonic anhydrase/acetyltransferase, isoleucine patch superfamily protein 622545 5645469 A1C_03450 Rickettsia akari str. Hartford carbonic anhydrase/acetyltransferase, isoleucine patch superfamily protein YP_001493482.1 622387 D 293614 CDS YP_001493483.1 157825763 5645470 complement(623031..623918) 1 NC_009881.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 623918 5645470 A1C_03455 Rickettsia akari str. Hartford bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_001493483.1 623031 R 293614 CDS YP_001493484.1 157825764 5645471 complement(623926..624225) 1 NC_009881.1 NADH dehydrogenase subunit N 624225 5645471 A1C_03460 Rickettsia akari str. Hartford NADH dehydrogenase subunit N YP_001493484.1 623926 R 293614 CDS YP_001493485.1 157825765 5645472 complement(624260..625264) 1 NC_009881.1 COG0492 Thioredoxin reductase; thioredoxin reductase 625264 5645472 A1C_03465 Rickettsia akari str. Hartford thioredoxin reductase YP_001493485.1 624260 R 293614 CDS YP_001493486.1 157825766 5645187 complement(625941..626015) 1 NC_009881.1 ribonucleotide-diphosphate reductase subunit alpha 626015 5645187 A1C_03470 Rickettsia akari str. Hartford ribonucleotide-diphosphate reductase subunit alpha YP_001493486.1 625941 R 293614 CDS YP_001493487.1 157825767 5645188 complement(626002..626253) 1 NC_009881.1 hypothetical protein 626253 5645188 A1C_03475 Rickettsia akari str. Hartford hypothetical protein YP_001493487.1 626002 R 293614 CDS YP_001493488.1 157825768 5645189 626481..628304 1 NC_009881.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 628304 5645189 A1C_03480 Rickettsia akari str. Hartford ribonucleotide-diphosphate reductase subunit alpha YP_001493488.1 626481 D 293614 CDS YP_001493489.1 157825769 5645190 628552..629535 1 NC_009881.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 629535 nrdF 5645190 nrdF Rickettsia akari str. Hartford ribonucleotide-diphosphate reductase subunit beta YP_001493489.1 628552 D 293614 CDS YP_001493490.1 157825770 5645191 629688..632546 1 NC_009881.1 COG1357 Uncharacterized low-complexity proteins; hypothetical protein 632546 5645191 A1C_03490 Rickettsia akari str. Hartford hypothetical protein YP_001493490.1 629688 D 293614 CDS YP_001493492.1 157825772 5645193 634142..634339 1 NC_009881.1 COG1943 Transposase and inactivated derivatives; transposase IS200-family protein 634339 5645193 A1C_03515 Rickettsia akari str. Hartford transposase IS200-family protein YP_001493492.1 634142 D 293614 CDS YP_001493493.1 157825773 5644612 634372..634629 1 NC_009881.1 hypothetical protein 634629 5644612 A1C_03520 Rickettsia akari str. Hartford hypothetical protein YP_001493493.1 634372 D 293614 CDS YP_001493494.1 157825774 5644613 634663..634848 1 NC_009881.1 hypothetical protein 634848 5644613 A1C_03525 Rickettsia akari str. Hartford hypothetical protein YP_001493494.1 634663 D 293614 CDS YP_001493495.1 157825775 5644614 complement(635172..636110) 1 NC_009881.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 636110 miaA 5644614 miaA Rickettsia akari str. Hartford tRNA delta(2)-isopentenylpyrophosphate transferase YP_001493495.1 635172 R 293614 CDS YP_001493496.1 157825776 5644615 complement(636513..637955) 1 NC_009881.1 COG1109 Phosphomannomutase; phosphomannomutase 637955 5644615 A1C_03535 Rickettsia akari str. Hartford phosphomannomutase YP_001493496.1 636513 R 293614 CDS YP_001493497.1 157825777 5644616 complement(638133..638855) 1 NC_009881.1 COG1137 ABC-type (unclassified) transport system, ATPase component; ABC transporter ATP-binding protein 638855 5644616 A1C_03540 Rickettsia akari str. Hartford ABC transporter ATP-binding protein YP_001493497.1 638133 R 293614 CDS YP_001493498.1 157825778 5644617 complement(638992..639369) 1 NC_009881.1 COG1934 Uncharacterized protein conserved in bacteria; hypothetical protein 639369 5644617 A1C_03545 Rickettsia akari str. Hartford hypothetical protein YP_001493498.1 638992 R 293614 CDS YP_001493499.1 157825779 5644618 complement(639395..639994) 1 NC_009881.1 COG5375 Uncharacterized protein conserved in bacteria; hypothetical protein 639994 5644618 A1C_03550 Rickettsia akari str. Hartford hypothetical protein YP_001493499.1 639395 R 293614 CDS YP_001493500.1 157825780 5645131 complement(640000..640959) 1 NC_009881.1 COG0794 Predicted sugar phosphate isomerase involved in capsule formation; KpsF protein 640959 5645131 A1C_03555 Rickettsia akari str. Hartford KpsF protein YP_001493500.1 640000 R 293614 CDS YP_001493501.1 157825781 5645132 complement(641211..643454) 1 NC_009881.1 COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase); polynucleotide phosphorylase/polyadenylase 643454 5645132 A1C_03560 Rickettsia akari str. Hartford polynucleotide phosphorylase/polyadenylase YP_001493501.1 641211 R 293614 CDS YP_001493502.1 157825782 5645133 complement(643615..643890) 1 NC_009881.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 643890 rpsO 5645133 rpsO Rickettsia akari str. Hartford 30S ribosomal protein S15 YP_001493502.1 643615 R 293614 CDS YP_001493503.1 157825783 5645134 complement(643912..644793) 1 NC_009881.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 644793 truB 5645134 truB Rickettsia akari str. Hartford tRNA pseudouridine synthase B YP_001493503.1 643912 R 293614 CDS YP_001493504.1 157825784 5645135 644917..646452 1 NC_009881.1 COG3202 ATP/ADP translocase; ADP,ATP carrier protein 646452 5645135 A1C_03575 Rickettsia akari str. Hartford ADP,ATP carrier protein YP_001493504.1 644917 D 293614 CDS YP_001493505.1 157825785 5645136 646721..649771 1 NC_009881.1 cell surface antigen 649771 5645136 A1C_03580 Rickettsia akari str. Hartford cell surface antigen YP_001493505.1 646721 D 293614 CDS YP_001493506.1 157825786 5645137 complement(649808..650002) 1 NC_009881.1 hypothetical protein 650002 5645137 A1C_03585 Rickettsia akari str. Hartford hypothetical protein YP_001493506.1 649808 R 293614 CDS YP_001493507.1 157825787 5645013 complement(650058..650255) 1 NC_009881.1 COG1943 Transposase and inactivated derivatives; transposase IS200-family protein 650255 5645013 A1C_03590 Rickettsia akari str. Hartford transposase IS200-family protein YP_001493507.1 650058 R 293614 CDS YP_001493508.1 157825788 5645014 complement(650622..651014) 1 NC_009881.1 COG1396 Predicted transcriptional regulators; hypothetical protein 651014 5645014 A1C_03595 Rickettsia akari str. Hartford hypothetical protein YP_001493508.1 650622 R 293614 CDS YP_001493509.1 157825789 5645015 651542..652369 1 NC_009881.1 COG1295 Predicted membrane protein; ribonuclease BN 652369 5645015 A1C_03600 Rickettsia akari str. Hartford ribonuclease BN YP_001493509.1 651542 D 293614 CDS YP_001493510.1 157825790 5645016 complement(652487..653320) 1 NC_009881.1 COG0174 Glutamine synthetase; glutamine synthetase 653320 5645016 A1C_03605 Rickettsia akari str. Hartford glutamine synthetase YP_001493510.1 652487 R 293614 CDS YP_001493511.1 157825791 5645017 653319..654041 1 NC_009881.1 COG1496 Uncharacterized conserved protein; hypothetical protein 654041 5645017 A1C_03610 Rickettsia akari str. Hartford hypothetical protein YP_001493511.1 653319 D 293614 CDS YP_001493512.1 157825792 5645018 654461..654850 1 NC_009881.1 COG0242 N-formylmethionyl-tRNA deformylase; polypeptide deformylase 654850 5645018 A1C_03615 Rickettsia akari str. Hartford polypeptide deformylase YP_001493512.1 654461 D 293614 CDS YP_001493513.1 157825793 5645019 655256..655621 1 NC_009881.1 hypothetical protein 655621 5645019 A1C_03620 Rickettsia akari str. Hartford hypothetical protein YP_001493513.1 655256 D 293614 CDS YP_001493514.1 157825794 5645158 complement(656163..656348) 1 NC_009881.1 hypothetical protein 656348 5645158 A1C_03625 Rickettsia akari str. Hartford hypothetical protein YP_001493514.1 656163 R 293614 CDS YP_001493515.1 157825795 5645159 complement(656807..658150) 1 NC_009881.1 hypothetical protein 658150 5645159 A1C_03630 Rickettsia akari str. Hartford hypothetical protein YP_001493515.1 656807 R 293614 CDS YP_001493516.1 157825796 5645160 658350..658466 1 NC_009881.1 pyruvate phosphate dikinase 658466 5645160 A1C_03635 Rickettsia akari str. Hartford pyruvate phosphate dikinase YP_001493516.1 658350 D 293614 CDS YP_001493517.1 157825797 5645161 complement(658545..661181) 1 NC_009881.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 661181 5645161 A1C_03640 Rickettsia akari str. Hartford pyruvate phosphate dikinase YP_001493517.1 658545 R 293614 CDS YP_001493518.1 157825798 5645162 662028..662696 1 NC_009881.1 COG0625 Glutathione S-transferase; glutathione S-transferase 662696 5645162 A1C_03645 Rickettsia akari str. Hartford glutathione S-transferase YP_001493518.1 662028 D 293614 CDS YP_001493519.1 157825799 5645163 complement(662659..663408) 1 NC_009881.1 COG4285 Uncharacterized conserved protein; hypothetical protein 663408 5645163 A1C_03650 Rickettsia akari str. Hartford hypothetical protein YP_001493519.1 662659 R 293614 CDS YP_001493520.1 157825800 5645164 complement(663441..663602) 1 NC_009881.1 hypothetical protein 663602 5645164 A1C_03655 Rickettsia akari str. Hartford hypothetical protein YP_001493520.1 663441 R 293614 CDS YP_001493521.1 157825801 5644869 663484..664026 1 NC_009881.1 COG1268 Uncharacterized conserved protein; BioY family protein 664026 5644869 A1C_03660 Rickettsia akari str. Hartford BioY family protein YP_001493521.1 663484 D 293614 CDS YP_001493522.1 157825802 5644870 664260..665549 1 NC_009881.1 COG0285 Folylpolyglutamate synthase; folylpolyglutamate synthase 665549 5644870 A1C_03665 Rickettsia akari str. Hartford folylpolyglutamate synthase YP_001493522.1 664260 D 293614 CDS YP_001493523.1 157825803 5644871 665708..666337 1 NC_009881.1 COG0605 Superoxide dismutase; superoxide dismutase 666337 5644871 A1C_03670 Rickettsia akari str. Hartford superoxide dismutase YP_001493523.1 665708 D 293614 CDS YP_001493524.1 157825804 5644872 667622..667732 1 NC_009881.1 hypothetical protein 667732 5644872 A1C_03690 Rickettsia akari str. Hartford hypothetical protein YP_001493524.1 667622 D 293614 CDS YP_001493525.1 157825805 5644873 668122..668925 1 NC_009881.1 COG0340 Biotin-(acetyl-CoA carboxylase) ligase; biotin--protein ligase 668925 5644873 A1C_03700 Rickettsia akari str. Hartford biotin--protein ligase YP_001493525.1 668122 D 293614 CDS YP_001493526.1 157825806 5644874 complement(669089..669253) 1 NC_009881.1 hypothetical protein 669253 5644874 A1C_03705 Rickettsia akari str. Hartford hypothetical protein YP_001493526.1 669089 R 293614 CDS YP_001493527.1 157825807 5644875 669443..669718 1 NC_009881.1 hypothetical protein 669718 5644875 A1C_03710 Rickettsia akari str. Hartford hypothetical protein YP_001493527.1 669443 D 293614 CDS YP_001493528.1 157825808 5645580 670773..671345 1 NC_009881.1 hypothetical protein 671345 5645580 A1C_03715 Rickettsia akari str. Hartford hypothetical protein YP_001493528.1 670773 D 293614 CDS YP_001493529.1 157825809 5645581 671432..671515 1 NC_009881.1 hypothetical protein 671515 5645581 A1C_03720 Rickettsia akari str. Hartford hypothetical protein YP_001493529.1 671432 D 293614 CDS YP_001493530.1 157825810 5645582 671524..671874 1 NC_009881.1 COG5448 Uncharacterized conserved protein; hypothetical protein 671874 5645582 A1C_03725 Rickettsia akari str. Hartford hypothetical protein YP_001493530.1 671524 D 293614 CDS YP_001493531.1 157825811 5645583 672089..672433 1 NC_009881.1 hypothetical protein 672433 5645583 A1C_03730 Rickettsia akari str. Hartford hypothetical protein YP_001493531.1 672089 D 293614 CDS YP_001493532.1 157825812 5645584 672448..672618 1 NC_009881.1 COG5449 Uncharacterized conserved protein; hypothetical protein 672618 5645584 A1C_03735 Rickettsia akari str. Hartford hypothetical protein YP_001493532.1 672448 D 293614 CDS YP_001493533.1 157825813 5645585 672622..672795 1 NC_009881.1 hypothetical protein 672795 5645585 A1C_03740 Rickettsia akari str. Hartford hypothetical protein YP_001493533.1 672622 D 293614 CDS YP_001493534.1 157825814 5645586 672782..673114 1 NC_009881.1 COG5346 Predicted membrane protein; hypothetical protein 673114 5645586 A1C_03745 Rickettsia akari str. Hartford hypothetical protein YP_001493534.1 672782 D 293614 CDS YP_001493535.1 157825815 5644656 673288..673731 1 NC_009881.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 673731 infC 5644656 infC Rickettsia akari str. Hartford translation initiation factor IF-3 YP_001493535.1 673288 D 293614 CDS YP_001493536.1 157825816 5644657 674008..675246 1 NC_009881.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; branched-chain alpha-keto acid dehydrogenase subunit E2 675246 5644657 A1C_03755 Rickettsia akari str. Hartford branched-chain alpha-keto acid dehydrogenase subunit E2 YP_001493536.1 674008 D 293614 CDS YP_001493537.1 157825817 5644658 675411..676478 1 NC_009881.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 676478 prfA 5644658 prfA Rickettsia akari str. Hartford peptide chain release factor 1 YP_001493537.1 675411 D 293614 CDS YP_001493538.1 157825818 5644659 676653..678416 1 NC_009881.1 COG0608 Single-stranded DNA-specific exonuclease; single-stranded-DNA-specific exonuclease RecJ 678416 5644659 A1C_03765 Rickettsia akari str. Hartford single-stranded-DNA-specific exonuclease RecJ YP_001493538.1 676653 D 293614 CDS YP_001493539.1 157825819 5644660 678641..679957 1 NC_009881.1 COG0500 SAM-dependent methyltransferases; putative methyltransferase 679957 5644660 A1C_03770 Rickettsia akari str. Hartford putative methyltransferase YP_001493539.1 678641 D 293614 CDS YP_001493540.1 157825820 5644661 680355..681731 1 NC_009881.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 681731 rho 5644661 rho Rickettsia akari str. Hartford transcription termination factor Rho YP_001493540.1 680355 D 293614 CDS YP_001493541.1 157825821 5644662 682576..682824 1 NC_009881.1 COG0776 Bacterial nucleoid DNA-binding protein; integration host factor beta-subunit 682824 5644662 A1C_03790 Rickettsia akari str. Hartford integration host factor beta-subunit YP_001493541.1 682576 D 293614 CDS YP_001493542.1 157825822 5644941 682899..683048 1 NC_009881.1 hypothetical protein 683048 5644941 A1C_03795 Rickettsia akari str. Hartford hypothetical protein YP_001493542.1 682899 D 293614 CDS YP_001493543.1 157825823 5644942 683301..683504 1 NC_009881.1 hypothetical protein 683504 5644942 A1C_03800 Rickettsia akari str. Hartford hypothetical protein YP_001493543.1 683301 D 293614 CDS YP_001493544.1 157825824 5644943 683507..683695 1 NC_009881.1 COG3022 Uncharacterized protein conserved in bacteria; hypothetical protein 683695 5644943 A1C_03805 Rickettsia akari str. Hartford hypothetical protein YP_001493544.1 683507 D 293614 CDS YP_001493545.1 157825825 5644944 683891..684046 1 NC_009881.1 COG0642 Signal transduction histidine kinase; Na+/proline symporter and signal transduction histidine kinase 684046 5644944 A1C_03810 Rickettsia akari str. Hartford Na+/proline symporter and signal transduction histidine kinase YP_001493545.1 683891 D 293614 CDS YP_001493546.1 157825826 5644945 684497..684577 1 NC_009881.1 hypothetical protein 684577 5644945 A1C_03815 Rickettsia akari str. Hartford hypothetical protein YP_001493546.1 684497 D 293614 CDS YP_001493547.1 157825827 5644946 684574..684702 1 NC_009881.1 microcin C7 resistance protein 684702 5644946 A1C_03820 Rickettsia akari str. Hartford microcin C7 resistance protein YP_001493547.1 684574 D 293614 CDS YP_001493548.1 157825828 5644947 684699..685604 1 NC_009881.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 685604 hemC 5644947 hemC Rickettsia akari str. Hartford porphobilinogen deaminase YP_001493548.1 684699 D 293614 CDS YP_001493549.1 157825829 5645440 complement(685755..686738) 1 NC_009881.1 COG0142 Geranylgeranyl pyrophosphate synthase; octaprenyl-diphosphate synthase 686738 5645440 A1C_03830 Rickettsia akari str. Hartford octaprenyl-diphosphate synthase YP_001493549.1 685755 R 293614 CDS YP_001493550.1 157825830 5645441 complement(686828..688483) 1 NC_009881.1 hypothetical protein 688483 5645441 A1C_03835 Rickettsia akari str. Hartford hypothetical protein YP_001493550.1 686828 R 293614 CDS YP_001493551.1 157825831 5645442 complement(688480..690015) 1 NC_009881.1 COG3202 ATP/ADP translocase; ADP,ATP carrier protein 690015 5645442 A1C_03840 Rickettsia akari str. Hartford ADP,ATP carrier protein YP_001493551.1 688480 R 293614 CDS YP_001493552.1 157825832 5645443 complement(690094..691554) 1 NC_009881.1 COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; lipopolysaccharide 1,2-glucosyltransferase RfaJ 691554 5645443 A1C_03845 Rickettsia akari str. Hartford lipopolysaccharide 1,2-glucosyltransferase RfaJ YP_001493552.1 690094 R 293614 CDS YP_001493553.1 157825833 5645444 692154..693473 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; AmpG-related permease 693473 5645444 A1C_03850 Rickettsia akari str. Hartford AmpG-related permease YP_001493553.1 692154 D 293614 CDS YP_001493554.1 157825834 5645838 694070..694744 1 NC_009881.1 hypothetical protein 694744 5645838 A1C_03865 Rickettsia akari str. Hartford hypothetical protein YP_001493554.1 694070 D 293614 CDS YP_001493555.1 157825835 5645839 694728..695420 1 NC_009881.1 hypothetical protein 695420 5645839 A1C_03870 Rickettsia akari str. Hartford hypothetical protein YP_001493555.1 694728 D 293614 CDS YP_001493556.1 157825836 5645840 695413..696417 1 NC_009881.1 COG0457 FOG: TPR repeat; hypothetical protein 696417 5645840 A1C_03875 Rickettsia akari str. Hartford hypothetical protein YP_001493556.1 695413 D 293614 CDS YP_001493557.1 157825837 5645841 complement(696697..697416) 1 NC_009881.1 COG2945 Predicted hydrolase of the alpha/beta superfamily; hypothetical protein 697416 5645841 A1C_03880 Rickettsia akari str. Hartford hypothetical protein YP_001493557.1 696697 R 293614 CDS YP_001493558.1 157825838 5645842 697584..697850 1 NC_009881.1 COG3077 DNA-damage-inducible protein J; DNA-damage-inducible protein J 697850 5645842 A1C_03885 Rickettsia akari str. Hartford DNA-damage-inducible protein J YP_001493558.1 697584 D 293614 CDS YP_001493559.1 157825839 5645843 697847..698041 1 NC_009881.1 COG3041 Uncharacterized protein conserved in bacteria; hypothetical protein 698041 5645843 A1C_03890 Rickettsia akari str. Hartford hypothetical protein YP_001493559.1 697847 D 293614 CDS YP_001493560.1 157825840 5645844 complement(698175..698615) 1 NC_009881.1 COG5622 Protein required for attachment to host cells; hypothetical protein 698615 5645844 A1C_03895 Rickettsia akari str. Hartford hypothetical protein YP_001493560.1 698175 R 293614 CDS YP_001493561.1 157825841 5645811 complement(698679..699254) 1 NC_009881.1 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; 1-acyl-sn-glycerol-3-phosphate acyltransferase 699254 5645811 A1C_03900 Rickettsia akari str. Hartford 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_001493561.1 698679 R 293614 CDS YP_001493562.1 157825842 5645812 699481..700473 1 NC_009881.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 700473 5645812 A1C_03905 Rickettsia akari str. Hartford tryptophanyl-tRNA synthetase YP_001493562.1 699481 D 293614 CDS YP_001493563.1 157825843 5645814 700997..701539 1 NC_009881.1 hydrolase or acyltransferase 701539 5645814 A1C_03910 Rickettsia akari str. Hartford hydrolase or acyltransferase YP_001493563.1 700997 D 293614 CDS YP_001493564.1 157825844 5645816 complement(701788..703605) 1 NC_009881.1 COG0006 Xaa-Pro aminopeptidase; aminopeptidase P 703605 5645816 A1C_03915 Rickettsia akari str. Hartford aminopeptidase P YP_001493564.1 701788 R 293614 CDS YP_001493565.1 157825845 5644856 complement(703652..704998) 1 NC_009881.1 COG0531 Amino acid transporters; putrescine-ornithine antiporter 704998 5644856 A1C_03920 Rickettsia akari str. Hartford putrescine-ornithine antiporter YP_001493565.1 703652 R 293614 CDS YP_001493566.1 157825846 5644857 complement(705357..705620) 1 NC_009881.1 hypothetical protein 705620 5644857 A1C_03925 Rickettsia akari str. Hartford hypothetical protein YP_001493566.1 705357 R 293614 CDS YP_001493567.1 157825847 5644858 complement(705617..705790) 1 NC_009881.1 hypothetical protein 705790 5644858 A1C_03930 Rickettsia akari str. Hartford hypothetical protein YP_001493567.1 705617 R 293614 CDS YP_001493568.1 157825848 5644859 complement(705816..706040) 1 NC_009881.1 hypothetical protein 706040 5644859 A1C_03935 Rickettsia akari str. Hartford hypothetical protein YP_001493568.1 705816 R 293614 CDS YP_001493569.1 157825849 5644860 complement(706206..706391) 1 NC_009881.1 hypothetical protein 706391 5644860 A1C_03940 Rickettsia akari str. Hartford hypothetical protein YP_001493569.1 706206 R 293614 CDS YP_001493570.1 157825850 5644861 complement(706397..706504) 1 NC_009881.1 hypothetical protein 706504 5644861 A1C_03945 Rickettsia akari str. Hartford hypothetical protein YP_001493570.1 706397 R 293614 CDS YP_001493571.1 157825851 5645672 complement(706666..706998) 1 NC_009881.1 COG0316 Uncharacterized conserved protein; Iron-sulfur cluster assembly accessory protein 706998 5645672 A1C_03950 Rickettsia akari str. Hartford Iron-sulfur cluster assembly accessory protein YP_001493571.1 706666 R 293614 CDS YP_001493572.1 157825852 5645673 complement(707002..707397) 1 NC_009881.1 COG0822 NifU homolog involved in Fe-S cluster formation; scaffold protein 707397 5645673 A1C_03955 Rickettsia akari str. Hartford scaffold protein YP_001493572.1 707002 R 293614 CDS YP_001493573.1 157825853 5645674 complement(707491..708723) 1 NC_009881.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 708723 5645674 A1C_03960 Rickettsia akari str. Hartford cysteine desulfurase YP_001493573.1 707491 R 293614 CDS YP_001493574.1 157825854 5645675 complement(708766..709881) 1 NC_009881.1 COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes; hypothetical protein 709881 5645675 A1C_03965 Rickettsia akari str. Hartford hypothetical protein YP_001493574.1 708766 R 293614 CDS YP_001493575.1 157825855 5645676 complement(709878..710264) 1 NC_009881.1 COG1959 Predicted transcriptional regulator; Iron-sulfur cluster assembly transcription factor IscR 710264 5645676 A1C_03970 Rickettsia akari str. Hartford Iron-sulfur cluster assembly transcription factor IscR YP_001493575.1 709878 R 293614 CDS YP_001493576.1 157825856 5645677 complement(710823..711695) 1 NC_009881.1 hypothetical protein 711695 5645677 A1C_03975 Rickettsia akari str. Hartford hypothetical protein YP_001493576.1 710823 R 293614 CDS YP_001493577.1 157825857 5645678 complement(712536..712649) 1 NC_009881.1 NTPase 712649 5645678 A1C_03980 Rickettsia akari str. Hartford NTPase YP_001493577.1 712536 R 293614 CDS YP_001493578.1 157825858 5645075 712868..714244 1 NC_009881.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 714244 5645075 A1C_03985 Rickettsia akari str. Hartford NADH dehydrogenase subunit N YP_001493578.1 712868 D 293614 CDS YP_001493579.1 157825859 5645076 complement(714231..715772) 1 NC_009881.1 hypothetical protein 715772 5645076 A1C_03990 Rickettsia akari str. Hartford hypothetical protein YP_001493579.1 714231 R 293614 CDS YP_001493580.1 157825860 5645077 complement(715867..716859) 1 NC_009881.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 716859 5645077 A1C_03995 Rickettsia akari str. Hartford delta-aminolevulinic acid dehydratase YP_001493580.1 715867 R 293614 CDS YP_001493581.1 157825861 5645078 complement(717412..719358) 1 NC_009881.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 719358 5645078 A1C_04000 Rickettsia akari str. Hartford primosome assembly protein PriA YP_001493581.1 717412 R 293614 CDS YP_001493582.1 157825862 5645079 719426..719992 1 NC_009881.1 COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase; aromatic acid decarboxylase 719992 5645079 A1C_04005 Rickettsia akari str. Hartford aromatic acid decarboxylase YP_001493582.1 719426 D 293614 CDS YP_001493583.1 157825863 5645080 720179..721663 1 NC_009881.1 unwinds double stranded DNA; replicative DNA helicase 721663 5645080 A1C_04010 Rickettsia akari str. Hartford replicative DNA helicase YP_001493583.1 720179 D 293614 CDS YP_001493584.1 157825864 5645081 complement(722162..722368) 1 NC_009881.1 putative to amino acid permeases 722368 5645081 A1C_04015 Rickettsia akari str. Hartford putative to amino acid permeases YP_001493584.1 722162 R 293614 CDS YP_001493585.1 157825865 5645270 complement(722481..722720) 1 NC_009881.1 COG0814 Amino acid permeases; putative to amino acid permeases 722720 5645270 A1C_04020 Rickettsia akari str. Hartford putative to amino acid permeases YP_001493585.1 722481 R 293614 CDS YP_001493586.1 157825866 5645271 723529..724218 1 NC_009881.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; ribosomal large subunit pseudouridine synthase 724218 5645271 A1C_04025 Rickettsia akari str. Hartford ribosomal large subunit pseudouridine synthase YP_001493586.1 723529 D 293614 CDS YP_001493587.1 157825867 5645272 724269..727133 1 NC_009881.1 COG1357 Uncharacterized low-complexity proteins; hypothetical protein 727133 5645272 A1C_04030 Rickettsia akari str. Hartford hypothetical protein YP_001493587.1 724269 D 293614 CDS YP_001493588.1 157825868 5645273 727138..727716 1 NC_009881.1 COG0742 N6-adenine-specific methylase; N6-adenine-specific methylase 727716 5645273 A1C_04035 Rickettsia akari str. Hartford N6-adenine-specific methylase YP_001493588.1 727138 D 293614 CDS YP_001493589.1 157825869 5645274 727815..729155 1 NC_009881.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 729155 5645274 A1C_04040 Rickettsia akari str. Hartford DNA repair protein RadA YP_001493589.1 727815 D 293614 CDS YP_001493590.1 157825870 5645275 729152..729469 1 NC_009881.1 COG0191 Fructose/tagatose bisphosphate aldolase; hypothetical protein 729469 5645275 A1C_04045 Rickettsia akari str. Hartford hypothetical protein YP_001493590.1 729152 D 293614 CDS YP_001493591.1 157825871 5645276 729544..730257 1 NC_009881.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 730257 recO 5645276 recO Rickettsia akari str. Hartford DNA repair protein RecO YP_001493591.1 729544 D 293614 CDS YP_001493592.1 157825872 5644825 730469..731155 1 NC_009881.1 COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone; putative glycoprotein endopeptidase 731155 5644825 A1C_04055 Rickettsia akari str. Hartford putative glycoprotein endopeptidase YP_001493592.1 730469 D 293614 CDS YP_001493593.1 157825873 5644826 complement(731189..732217) 1 NC_009881.1 COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain); hypothetical protein 732217 5644826 A1C_04060 Rickettsia akari str. Hartford hypothetical protein YP_001493593.1 731189 R 293614 CDS YP_001493594.1 157825874 5644827 complement(732469..734958) 1 NC_009881.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 734958 infB 5644827 infB Rickettsia akari str. Hartford translation initiation factor IF-2 YP_001493594.1 732469 R 293614 CDS YP_001493595.1 157825875 5644828 complement(735212..736723) 1 NC_009881.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 736723 nusA 5644828 nusA Rickettsia akari str. Hartford transcription elongation factor NusA YP_001493595.1 735212 R 293614 CDS YP_001493596.1 157825876 5644829 complement(736813..737313) 1 NC_009881.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 737313 5644829 A1C_04075 Rickettsia akari str. Hartford hypothetical protein YP_001493596.1 736813 R 293614 CDS YP_001493597.1 157825877 5644830 complement(737653..738042) 1 NC_009881.1 COG3177 Uncharacterized conserved protein; hypothetical protein 738042 5644830 A1C_04080 Rickettsia akari str. Hartford hypothetical protein YP_001493597.1 737653 R 293614 CDS YP_001493598.1 157825878 5644831 complement(738112..738204) 1 NC_009881.1 hypothetical protein 738204 5644831 A1C_04085 Rickettsia akari str. Hartford hypothetical protein YP_001493598.1 738112 R 293614 CDS YP_001493599.1 157825879 5645417 complement(738643..739386) 1 NC_009881.1 COG1189 Predicted rRNA methylase; hemolysin A 739386 5645417 A1C_04090 Rickettsia akari str. Hartford hemolysin A YP_001493599.1 738643 R 293614 CDS YP_001493600.1 157825880 5645418 complement(739550..740785) 1 NC_009881.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 740785 5645418 A1C_04095 Rickettsia akari str. Hartford tyrosyl-tRNA synthetase YP_001493600.1 739550 R 293614 CDS YP_001493601.1 157825881 5645419 complement(740902..741069) 1 NC_009881.1 hypothetical protein 741069 5645419 A1C_04100 Rickettsia akari str. Hartford hypothetical protein YP_001493601.1 740902 R 293614 CDS YP_001493602.1 157825882 5645420 complement(741824..742192) 1 NC_009881.1 hypothetical protein 742192 5645420 A1C_04105 Rickettsia akari str. Hartford hypothetical protein YP_001493602.1 741824 R 293614 CDS YP_001493603.1 157825883 5645421 complement(742194..742532) 1 NC_009881.1 hypothetical protein 742532 5645421 A1C_04110 Rickettsia akari str. Hartford hypothetical protein YP_001493603.1 742194 R 293614 CDS YP_001493604.1 157825884 5645422 complement(742836..743762) 1 NC_009881.1 COG0354 Predicted aminomethyltransferase related to GcvT; hypothetical protein 743762 5645422 A1C_04115 Rickettsia akari str. Hartford hypothetical protein YP_001493604.1 742836 R 293614 CDS YP_001493605.1 157825885 5645423 743875..744666 1 NC_009881.1 COG1723 Uncharacterized conserved protein; hypothetical protein 744666 5645423 A1C_04120 Rickettsia akari str. Hartford hypothetical protein YP_001493605.1 743875 D 293614 CDS YP_001493606.1 157825886 5645445 744676..745521 1 NC_009881.1 COG0349 Ribonuclease D; ribonuclease D 745521 5645445 A1C_04125 Rickettsia akari str. Hartford ribonuclease D YP_001493606.1 744676 D 293614 CDS YP_001493607.1 157825887 5645446 complement(745747..746091) 1 NC_009881.1 COG0212 5-formyltetrahydrofolate cyclo-ligase; 5-formyltetrahydrofolate cyclo-ligase 746091 5645446 A1C_04130 Rickettsia akari str. Hartford 5-formyltetrahydrofolate cyclo-ligase YP_001493607.1 745747 R 293614 CDS YP_001493608.1 157825888 5645447 complement(746259..747638) 1 NC_009881.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 747638 5645447 A1C_04135 Rickettsia akari str. Hartford dihydrolipoamide dehydrogenase YP_001493608.1 746259 R 293614 CDS YP_001493609.1 157825889 5645448 complement(747786..748466) 1 NC_009881.1 COG0500 SAM-dependent methyltransferases; biotin synthesis protein BioC 748466 5645448 A1C_04140 Rickettsia akari str. Hartford biotin synthesis protein BioC YP_001493609.1 747786 R 293614 CDS YP_001493610.1 157825890 5645449 complement(748646..748867) 1 NC_009881.1 hypothetical protein 748867 5645449 A1C_04145 Rickettsia akari str. Hartford hypothetical protein YP_001493610.1 748646 R 293614 CDS YP_001493611.1 157825891 5645450 complement(749086..749601) 1 NC_009881.1 hypothetical protein 749601 5645450 A1C_04150 Rickettsia akari str. Hartford hypothetical protein YP_001493611.1 749086 R 293614 CDS YP_001493612.1 157825892 5645451 complement(749699..750520) 1 NC_009881.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); hypothetical protein 750520 5645451 A1C_04155 Rickettsia akari str. Hartford hypothetical protein YP_001493612.1 749699 R 293614 CDS YP_001493613.1 157825893 5645332 complement(751326..751499) 1 NC_009881.1 hypothetical protein 751499 5645332 A1C_04160 Rickettsia akari str. Hartford hypothetical protein YP_001493613.1 751326 R 293614 CDS YP_001493614.1 157825894 5645333 complement(751554..751949) 1 NC_009881.1 hypothetical protein 751949 5645333 A1C_04165 Rickettsia akari str. Hartford hypothetical protein YP_001493614.1 751554 R 293614 CDS YP_001493615.1 157825895 5645334 752054..752179 1 NC_009881.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 752179 rpmJ 5645334 rpmJ Rickettsia akari str. Hartford 50S ribosomal protein L36 YP_001493615.1 752054 D 293614 CDS YP_001493616.1 157825896 5645335 752197..752955 1 NC_009881.1 COG0217 Uncharacterized conserved protein; hypothetical protein 752955 5645335 A1C_04175 Rickettsia akari str. Hartford hypothetical protein YP_001493616.1 752197 D 293614 CDS YP_001493617.1 157825897 5645336 752952..753698 1 NC_009881.1 COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains); UDP-N-acetylglucosamine pyrophosphorylase 753698 5645336 A1C_04180 Rickettsia akari str. Hartford UDP-N-acetylglucosamine pyrophosphorylase YP_001493617.1 752952 D 293614 CDS YP_001493618.1 157825898 5645338 754483..754638 1 NC_009881.1 isopentenyl pyrophosphate isomerase 754638 5645338 A1C_04190 Rickettsia akari str. Hartford isopentenyl pyrophosphate isomerase YP_001493618.1 754483 D 293614 CDS YP_001493619.1 157825899 5645230 complement(754941..755969) 1 NC_009881.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 755969 5645230 A1C_04195 Rickettsia akari str. Hartford isopentenyl pyrophosphate isomerase YP_001493619.1 754941 R 293614 CDS YP_001493620.1 157825900 5645231 756146..756304 1 NC_009881.1 acetyltransferase 756304 5645231 A1C_04200 Rickettsia akari str. Hartford acetyltransferase YP_001493620.1 756146 D 293614 CDS YP_001493621.1 157825901 5645232 756408..756839 1 NC_009881.1 ankyrin repeat-containing protein 756839 5645232 A1C_04205 Rickettsia akari str. Hartford ankyrin repeat-containing protein YP_001493621.1 756408 D 293614 CDS YP_001493622.1 157825902 5645233 756887..756958 1 NC_009881.1 hypothetical protein 756958 5645233 A1C_04210 Rickettsia akari str. Hartford hypothetical protein YP_001493622.1 756887 D 293614 CDS YP_001493623.1 157825903 5645234 complement(756985..757128) 1 NC_009881.1 hypothetical protein 757128 5645234 A1C_04215 Rickettsia akari str. Hartford hypothetical protein YP_001493623.1 756985 R 293614 CDS YP_001493624.1 157825904 5645235 757465..757683 1 NC_009881.1 hypothetical protein 757683 5645235 A1C_04220 Rickettsia akari str. Hartford hypothetical protein YP_001493624.1 757465 D 293614 CDS YP_001493625.1 157825905 5645236 complement(757686..757889) 1 NC_009881.1 acetyltransferase 757889 5645236 A1C_04225 Rickettsia akari str. Hartford acetyltransferase YP_001493625.1 757686 R 293614 CDS YP_001493626.1 157825906 5645237 complement(757986..758300) 1 NC_009881.1 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; acetyltransferase 758300 5645237 A1C_04230 Rickettsia akari str. Hartford acetyltransferase YP_001493626.1 757986 R 293614 CDS YP_001493627.1 157825907 5645588 complement(759326..759931) 1 NC_009881.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 759931 clpP 5645588 clpP Rickettsia akari str. Hartford ATP-dependent Clp protease proteolytic subunit YP_001493627.1 759326 R 293614 CDS YP_001493628.1 157825908 5645589 complement(760175..761881) 1 NC_009881.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 761881 rpsA 5645589 rpsA Rickettsia akari str. Hartford 30S ribosomal protein S1 YP_001493628.1 760175 R 293614 CDS YP_001493629.1 157825909 5645590 complement(762143..762802) 1 NC_009881.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 762802 cmk 5645590 cmk Rickettsia akari str. Hartford cytidylate kinase YP_001493629.1 762143 R 293614 CDS YP_001493630.1 157825910 5645592 complement(763363..763656) 1 NC_009881.1 transposase Tn5 763656 5645592 A1C_04250 Rickettsia akari str. Hartford transposase Tn5 YP_001493630.1 763363 R 293614 CDS YP_001493631.1 157825911 5645027 complement(763779..763928) 1 NC_009881.1 transposase Tn5 763928 5645027 A1C_04255 Rickettsia akari str. Hartford transposase Tn5 YP_001493631.1 763779 R 293614 CDS YP_001493632.1 157825912 5645028 complement(764964..765272) 1 NC_009881.1 COG1301 Na+/H+-dicarboxylate symporters; hypothetical protein 765272 5645028 A1C_04260 Rickettsia akari str. Hartford hypothetical protein YP_001493632.1 764964 R 293614 CDS YP_001493633.1 157825913 5645029 complement(765370..765666) 1 NC_009881.1 hypothetical protein 765666 5645029 A1C_04265 Rickettsia akari str. Hartford hypothetical protein YP_001493633.1 765370 R 293614 CDS YP_001493634.1 157825914 5645030 765704..766015 1 NC_009881.1 hypothetical protein 766015 5645030 A1C_04270 Rickettsia akari str. Hartford hypothetical protein YP_001493634.1 765704 D 293614 CDS YP_001493635.1 157825915 5645031 complement(766674..766805) 1 NC_009881.1 hypothetical protein 766805 5645031 A1C_04275 Rickettsia akari str. Hartford hypothetical protein YP_001493635.1 766674 R 293614 CDS YP_001493636.1 157825916 5645032 767339..767434 1 NC_009881.1 hypothetical protein 767434 5645032 A1C_04280 Rickettsia akari str. Hartford hypothetical protein YP_001493636.1 767339 D 293614 CDS YP_001493637.1 157825917 5644809 767434..767568 1 NC_009881.1 hypothetical protein 767568 5644809 A1C_04285 Rickettsia akari str. Hartford hypothetical protein YP_001493637.1 767434 D 293614 CDS YP_001493638.1 157825918 5644810 767600..767683 1 NC_009881.1 hypothetical protein 767683 5644810 A1C_04290 Rickettsia akari str. Hartford hypothetical protein YP_001493638.1 767600 D 293614 CDS YP_001493639.1 157825919 5644811 767744..767881 1 NC_009881.1 hypothetical protein 767881 5644811 A1C_04295 Rickettsia akari str. Hartford hypothetical protein YP_001493639.1 767744 D 293614 CDS YP_001493640.1 157825920 5644812 767973..768101 1 NC_009881.1 hypothetical protein 768101 5644812 A1C_04300 Rickettsia akari str. Hartford hypothetical protein YP_001493640.1 767973 D 293614 CDS YP_001493641.1 157825921 5644813 768141..768359 1 NC_009881.1 COG3328 Transposase and inactivated derivatives; transposase, mutator type 768359 5644813 A1C_04305 Rickettsia akari str. Hartford transposase, mutator type YP_001493641.1 768141 D 293614 CDS YP_001493642.1 157825922 5644814 768858..769121 1 NC_009881.1 COG3328 Transposase and inactivated derivatives; transposase 769121 5644814 A1C_04310 Rickettsia akari str. Hartford transposase YP_001493642.1 768858 D 293614 CDS YP_001493643.1 157825923 5644815 complement(769137..769331) 1 NC_009881.1 COG1943 Transposase and inactivated derivatives; transposase IS200-family protein 769331 5644815 A1C_04315 Rickettsia akari str. Hartford transposase IS200-family protein YP_001493643.1 769137 R 293614 CDS YP_001493644.1 157825924 5645345 771031..776712 1 NC_009881.1 COG2373 Large extracellular alpha-helical protein; large extracellular alpha-helical protein 776712 5645345 A1C_04320 Rickettsia akari str. Hartford large extracellular alpha-helical protein YP_001493644.1 771031 D 293614 CDS YP_001493645.1 157825925 5645346 complement(776810..778975) 1 NC_009881.1 COG1250 3-hydroxyacyl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase 778975 5645346 A1C_04325 Rickettsia akari str. Hartford 3-hydroxyacyl-CoA dehydrogenase YP_001493645.1 776810 R 293614 CDS YP_001493646.1 157825926 5645347 complement(779229..779423) 1 NC_009881.1 hypothetical protein 779423 5645347 A1C_04330 Rickettsia akari str. Hartford hypothetical protein YP_001493646.1 779229 R 293614 CDS YP_001493647.1 157825927 5645348 complement(779804..780403) 1 NC_009881.1 COG0474 Cation transport ATPase; hypothetical protein 780403 5645348 A1C_04335 Rickettsia akari str. Hartford hypothetical protein YP_001493647.1 779804 R 293614 CDS YP_001493648.1 157825928 5645349 complement(780372..780728) 1 NC_009881.1 hypothetical protein 780728 5645349 A1C_04340 Rickettsia akari str. Hartford hypothetical protein YP_001493648.1 780372 R 293614 CDS YP_001493649.1 157825929 5645350 complement(780834..781004) 1 NC_009881.1 2-octaprenyl-6-methoxyphenyl hydroxylase 781004 5645350 A1C_04345 Rickettsia akari str. Hartford 2-octaprenyl-6-methoxyphenyl hydroxylase YP_001493649.1 780834 R 293614 CDS YP_001493650.1 157825930 5644832 complement(781354..782490) 1 NC_009881.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 782490 5644832 A1C_04350 Rickettsia akari str. Hartford 2-octaprenyl-6-methoxyphenyl hydroxylase YP_001493650.1 781354 R 293614 CDS YP_001493651.1 157825931 5644833 complement(782471..782737) 1 NC_009881.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit F 782737 5644833 A1C_04355 Rickettsia akari str. Hartford putative monovalent cation/H+ antiporter subunit F YP_001493651.1 782471 R 293614 CDS YP_001493652.1 157825932 5644834 783159..784586 1 NC_009881.1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; nitrogen assimilation regulatory protein NtrX 784586 5644834 A1C_04360 Rickettsia akari str. Hartford nitrogen assimilation regulatory protein NtrX YP_001493652.1 783159 D 293614 CDS YP_001493653.1 157825933 5644835 784579..786324 1 NC_009881.1 COG1357 Uncharacterized low-complexity proteins; hypothetical protein 786324 5644835 A1C_04365 Rickettsia akari str. Hartford hypothetical protein YP_001493653.1 784579 D 293614 CDS YP_001493654.1 157825934 5644836 complement(786580..787578) 1 NC_009881.1 hypothetical protein 787578 5644836 A1C_04370 Rickettsia akari str. Hartford hypothetical protein YP_001493654.1 786580 R 293614 CDS YP_001493655.1 157825935 5644837 complement(787837..787989) 1 NC_009881.1 hypothetical protein 787989 5644837 A1C_04375 Rickettsia akari str. Hartford hypothetical protein YP_001493655.1 787837 R 293614 CDS YP_001493656.1 157825936 5644838 complement(788080..788694) 1 NC_009881.1 COG0666 FOG: Ankyrin repeat; ankyrin repeat-containing protein 788694 5644838 A1C_04380 Rickettsia akari str. Hartford ankyrin repeat-containing protein YP_001493656.1 788080 R 293614 CDS YP_001493657.1 157825937 5644839 complement(789117..790901) 1 NC_009881.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2; penicillin-binding protein 790901 5644839 A1C_04385 Rickettsia akari str. Hartford penicillin-binding protein YP_001493657.1 789117 R 293614 CDS YP_001493658.1 157825938 5644848 complement(790891..791412) 1 NC_009881.1 hypothetical protein 791412 5644848 A1C_04390 Rickettsia akari str. Hartford hypothetical protein YP_001493658.1 790891 R 293614 CDS YP_001493659.1 157825939 5644849 complement(791777..793462) 1 NC_009881.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2; penicillin-binding protein 793462 5644849 A1C_04395 Rickettsia akari str. Hartford penicillin-binding protein YP_001493659.1 791777 R 293614 CDS YP_001493660.1 157825940 5644850 complement(793613..794011) 1 NC_009881.1 cell division protein FtsL 794011 5644850 A1C_04400 Rickettsia akari str. Hartford cell division protein FtsL YP_001493660.1 793613 R 293614 CDS YP_001493661.1 157825941 5644851 complement(794295..795215) 1 NC_009881.1 COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; S-adenosyl-methyltransferase MraW 795215 mraW 5644851 mraW Rickettsia akari str. Hartford S-adenosyl-methyltransferase MraW YP_001493661.1 794295 R 293614 CDS YP_001493662.1 157825942 5644852 complement(795215..795664) 1 NC_009881.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 795664 5644852 A1C_04410 Rickettsia akari str. Hartford cell division protein MraZ YP_001493662.1 795215 R 293614 CDS YP_001493663.1 157825943 5644853 796216..797625 1 NC_009881.1 COG0591 Na+/proline symporter; Sodium/pantothenate symporter 797625 5644853 A1C_04415 Rickettsia akari str. Hartford Sodium/pantothenate symporter YP_001493663.1 796216 D 293614 CDS YP_001493664.1 157825944 5644854 797847..798023 1 NC_009881.1 COG2161 Antitoxin of toxin-antitoxin stability system; antitoxin of toxin-antitoxin system StbD 798023 5644854 A1C_04420 Rickettsia akari str. Hartford antitoxin of toxin-antitoxin system StbD YP_001493664.1 797847 D 293614 CDS YP_001493665.1 157825945 5644855 798086..798316 1 NC_009881.1 toxin of toxin-antitoxin system 798316 5644855 A1C_04425 Rickettsia akari str. Hartford toxin of toxin-antitoxin system YP_001493665.1 798086 D 293614 CDS YP_001493666.1 157825946 5645752 complement(798356..800311) 1 NC_009881.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 800311 uvrC 5645752 uvrC Rickettsia akari str. Hartford excinuclease ABC subunit C YP_001493666.1 798356 R 293614 CDS YP_001493667.1 157825947 5645753 complement(800407..800937) 1 NC_009881.1 COG2847 Uncharacterized protein conserved in bacteria; hypothetical protein 800937 5645753 A1C_04435 Rickettsia akari str. Hartford hypothetical protein YP_001493667.1 800407 R 293614 CDS YP_001493668.1 157825948 5645754 complement(801086..801280) 1 NC_009881.1 COG4912 Predicted DNA alkylation repair enzyme; hypothetical protein 801280 5645754 A1C_04440 Rickettsia akari str. Hartford hypothetical protein YP_001493668.1 801086 R 293614 CDS YP_001493669.1 157825949 5645755 802302..802598 1 NC_009881.1 hypothetical protein 802598 5645755 A1C_04455 Rickettsia akari str. Hartford hypothetical protein YP_001493669.1 802302 D 293614 CDS YP_001493670.1 157825950 5645756 802591..802701 1 NC_009881.1 hypothetical protein 802701 5645756 A1C_04460 Rickettsia akari str. Hartford hypothetical protein YP_001493670.1 802591 D 293614 CDS YP_001493671.1 157825951 5645757 complement(803291..803554) 1 NC_009881.1 hypothetical protein 803554 5645757 A1C_04465 Rickettsia akari str. Hartford hypothetical protein YP_001493671.1 803291 R 293614 CDS YP_001493672.1 157825952 5645759 complement(803956..804171) 1 NC_009881.1 hypothetical protein 804171 5645759 A1C_04470 Rickettsia akari str. Hartford hypothetical protein YP_001493672.1 803956 R 293614 CDS YP_001493673.1 157825953 5645339 complement(804359..804907) 1 NC_009881.1 COG0666 FOG: Ankyrin repeat; ankyrin repeat-containing protein 804907 5645339 A1C_04475 Rickettsia akari str. Hartford ankyrin repeat-containing protein YP_001493673.1 804359 R 293614 CDS YP_001493674.1 157825954 5645340 complement(804983..805078) 1 NC_009881.1 hypothetical protein 805078 5645340 A1C_04480 Rickettsia akari str. Hartford hypothetical protein YP_001493674.1 804983 R 293614 CDS YP_001493675.1 157825955 5645341 complement(805549..808269) 1 NC_009881.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 808269 5645341 A1C_04485 Rickettsia akari str. Hartford preprotein translocase subunit SecA YP_001493675.1 805549 R 293614 CDS YP_001493676.1 157825956 5645342 808520..809368 1 NC_009881.1 COG0760 Parvulin-like peptidyl-prolyl isomerase; protein export protein prsA 809368 5645342 A1C_04490 Rickettsia akari str. Hartford protein export protein prsA YP_001493676.1 808520 D 293614 CDS YP_001493677.1 157825957 5645343 complement(809625..810005) 1 NC_009881.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 810005 acpS 5645343 acpS Rickettsia akari str. Hartford 4'-phosphopantetheinyl transferase YP_001493677.1 809625 R 293614 CDS YP_001493678.1 157825958 5645344 complement(810006..810389) 1 NC_009881.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 810389 rpoZ 5645344 rpoZ Rickettsia akari str. Hartford DNA-directed RNA polymerase subunit omega YP_001493678.1 810006 R 293614 CDS YP_001493679.1 157825959 5645512 complement(810559..811818) 1 NC_009881.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 811818 5645512 A1C_04505 Rickettsia akari str. Hartford UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_001493679.1 810559 R 293614 CDS YP_001493680.1 157825960 5645513 complement(812158..814581) 1 NC_009881.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 814581 gyrB 5645513 gyrB Rickettsia akari str. Hartford DNA gyrase subunit B YP_001493680.1 812158 R 293614 CDS YP_001493681.1 157825961 5645514 814806..815666 1 NC_009881.1 COG0647 Predicted sugar phosphatases of the HAD superfamily; HAD family hydrolase 815666 5645514 A1C_04515 Rickettsia akari str. Hartford HAD family hydrolase YP_001493681.1 814806 D 293614 CDS YP_001493682.1 157825962 5645516 816336..817706 1 NC_009881.1 COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain); magnesium transporter 817706 5645516 A1C_04520 Rickettsia akari str. Hartford magnesium transporter YP_001493682.1 816336 D 293614 CDS YP_001493683.1 157825963 5645517 complement(818072..818317) 1 NC_009881.1 hypothetical protein 818317 5645517 A1C_04525 Rickettsia akari str. Hartford hypothetical protein YP_001493683.1 818072 R 293614 CDS YP_001493684.1 157825964 5645524 complement(819015..819320) 1 NC_009881.1 proline/betaine transporter 819320 5645524 A1C_04540 Rickettsia akari str. Hartford proline/betaine transporter YP_001493684.1 819015 R 293614 CDS YP_001493685.1 157825965 5645526 complement(821488..821574) 1 NC_009881.1 preprotein translocase subunit YajC 821574 yajC 5645526 yajC Rickettsia akari str. Hartford preprotein translocase subunit YajC YP_001493685.1 821488 R 293614 CDS YP_001493686.1 157825966 5645527 821649..822077 1 NC_009881.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 822077 yajC 5645527 yajC Rickettsia akari str. Hartford preprotein translocase subunit YajC YP_001493686.1 821649 D 293614 CDS YP_001493687.1 157825967 5645528 822061..823617 1 NC_009881.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 823617 secD 5645528 secD Rickettsia akari str. Hartford preprotein translocase subunit SecD YP_001493687.1 822061 D 293614 CDS YP_001493688.1 157825968 5645529 823860..824477 1 NC_009881.1 COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems; sco2 protein 824477 5645529 A1C_04570 Rickettsia akari str. Hartford sco2 protein YP_001493688.1 823860 D 293614 CDS YP_001493689.1 157825969 5645530 824579..824965 1 NC_009881.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 824965 5645530 A1C_04575 Rickettsia akari str. Hartford cytochrome c-type biogenesis protein CcmE YP_001493689.1 824579 D 293614 CDS YP_001493690.1 157825970 5644663 825093..825614 1 NC_009881.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 825614 5644663 A1C_04580 Rickettsia akari str. Hartford inorganic pyrophosphatase YP_001493690.1 825093 D 293614 CDS YP_001493691.1 157825971 5644664 825847..827370 1 NC_009881.1 COG0728 Uncharacterized membrane protein, putative virulence factor; virulence factor mviN 827370 5644664 A1C_04585 Rickettsia akari str. Hartford virulence factor mviN YP_001493691.1 825847 D 293614 CDS YP_001493692.1 157825972 5644665 827351..828097 1 NC_009881.1 F pilin acetylation protein TraX 828097 5644665 A1C_04590 Rickettsia akari str. Hartford F pilin acetylation protein TraX YP_001493692.1 827351 D 293614 CDS YP_001493693.1 157825973 5644666 828171..828773 1 NC_009881.1 hypothetical protein 828773 5644666 A1C_04595 Rickettsia akari str. Hartford hypothetical protein YP_001493693.1 828171 D 293614 CDS YP_001493694.1 157825974 5644667 complement(829627..831858) 1 NC_009881.1 COG1200 RecG-like helicase; ATP-dependent DNA helicase RecG 831858 5644667 A1C_04600 Rickettsia akari str. Hartford ATP-dependent DNA helicase RecG YP_001493694.1 829627 R 293614 CDS YP_001493695.1 157825975 5644668 832429..832563 1 NC_009881.1 hypothetical protein 832563 5644668 A1C_04605 Rickettsia akari str. Hartford hypothetical protein YP_001493695.1 832429 D 293614 CDS YP_001493696.1 157825976 5644669 complement(832750..833955) 1 NC_009881.1 hypothetical protein 833955 5644669 A1C_04610 Rickettsia akari str. Hartford hypothetical protein YP_001493696.1 832750 R 293614 CDS YP_001493697.1 157825977 5644670 834114..834335 1 NC_009881.1 COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit; succinyl-CoA:3-ketoacid-coenzyme A transferase 834335 5644670 A1C_04615 Rickettsia akari str. Hartford succinyl-CoA:3-ketoacid-coenzyme A transferase YP_001493697.1 834114 D 293614 CDS YP_001493698.1 157825978 5644604 834332..834415 1 NC_009881.1 succinyl-CoA:3-ketoacid-coenzyme A transferase 834415 5644604 A1C_04620 Rickettsia akari str. Hartford succinyl-CoA:3-ketoacid-coenzyme A transferase YP_001493698.1 834332 D 293614 CDS YP_001493699.1 157825979 5644605 834567..834812 1 NC_009881.1 COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit; hypothetical protein 834812 5644605 A1C_04625 Rickettsia akari str. Hartford hypothetical protein YP_001493699.1 834567 D 293614 CDS YP_001493700.1 157825980 5644606 complement(836378..837949) 1 NC_009881.1 Actin polymerization protein RickA 837949 5644606 A1C_04650 Rickettsia akari str. Hartford Actin polymerization protein RickA YP_001493700.1 836378 R 293614 CDS YP_001493701.1 157825981 5644607 836934..837068 1 NC_009881.1 phospho-N-acetylmuramoyl-pentapeptide- transferase 837068 mraY 5644607 mraY Rickettsia akari str. Hartford phospho-N-acetylmuramoyl-pentapeptide- transferase YP_001493701.1 836934 D 293614 CDS YP_001493702.1 157825982 5644608 complement(838033..839178) 1 NC_009881.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 839178 mraY 5644608 mraY Rickettsia akari str. Hartford phospho-N-acetylmuramoyl-pentapeptide- transferase YP_001493702.1 838033 R 293614 CDS YP_001493703.1 157825983 5644609 complement(839258..840607) 1 NC_009881.1 COG0770 UDP-N-acetylmuramyl pentapeptide synthase; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate--D-alanyl-D-alanine ligase 840607 5644609 A1C_04665 Rickettsia akari str. Hartford UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate--D-alanyl-D-alanine ligase YP_001493703.1 839258 R 293614 CDS YP_001493704.1 157825984 5644610 complement(840749..842191) 1 NC_009881.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 842191 murE 5644610 murE Rickettsia akari str. Hartford UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_001493704.1 840749 R 293614 CDS YP_001493705.1 157825985 5644611 complement(842384..845749) 1 NC_009881.1 COG1197 Transcription-repair coupling factor (superfamily II helicase); transcription-repair coupling factor 845749 5644611 A1C_04675 Rickettsia akari str. Hartford transcription-repair coupling factor YP_001493705.1 842384 R 293614 CDS YP_001493706.1 157825986 5644817 complement(845761..846024) 1 NC_009881.1 COG2938 Uncharacterized conserved protein; hypothetical protein 846024 5644817 A1C_04680 Rickettsia akari str. Hartford hypothetical protein YP_001493706.1 845761 R 293614 CDS YP_001493707.1 157825987 5644818 846344..846715 1 NC_009881.1 COG0607 Rhodanese-related sulfurtransferase; hypothetical protein 846715 5644818 A1C_04685 Rickettsia akari str. Hartford hypothetical protein YP_001493707.1 846344 D 293614 CDS YP_001493708.1 157825988 5644819 846716..848107 1 NC_009881.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 848107 dnaA 5644819 dnaA Rickettsia akari str. Hartford chromosomal replication initiation protein YP_001493708.1 846716 D 293614 CDS YP_001493709.1 157825989 5644820 complement(848254..848589) 1 NC_009881.1 hypothetical protein 848589 5644820 A1C_04695 Rickettsia akari str. Hartford hypothetical protein YP_001493709.1 848254 R 293614 CDS YP_001493710.1 157825990 5644821 complement(848626..848841) 1 NC_009881.1 hypothetical protein 848841 5644821 A1C_04700 Rickettsia akari str. Hartford hypothetical protein YP_001493710.1 848626 R 293614 CDS YP_001493711.1 157825991 5644822 complement(848849..849082) 1 NC_009881.1 hypothetical protein 849082 5644822 A1C_04705 Rickettsia akari str. Hartford hypothetical protein YP_001493711.1 848849 R 293614 CDS YP_001493712.1 157825992 5644823 850045..851553 1 NC_009881.1 COG3621 Patatin; patatin-like phospholipase 851553 5644823 A1C_04710 Rickettsia akari str. Hartford patatin-like phospholipase YP_001493712.1 850045 D 293614 CDS YP_001493713.1 157825993 5644824 complement(851757..852980) 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; bicyclomycin resistance protein 852980 5644824 A1C_04715 Rickettsia akari str. Hartford bicyclomycin resistance protein YP_001493713.1 851757 R 293614 CDS YP_001493714.1 157825994 5645480 complement(854013..855110) 1 NC_009881.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 855110 5645480 A1C_04730 Rickettsia akari str. Hartford GTP-dependent nucleic acid-binding protein EngD YP_001493714.1 854013 R 293614 CDS YP_001493715.1 157825995 5645481 complement(855067..855216) 1 NC_009881.1 acetyltransferase 855216 5645481 A1C_04735 Rickettsia akari str. Hartford acetyltransferase YP_001493715.1 855067 R 293614 CDS YP_001493716.1 157825996 5645482 complement(855358..855534) 1 NC_009881.1 acetyltransferase 855534 5645482 A1C_04740 Rickettsia akari str. Hartford acetyltransferase YP_001493716.1 855358 R 293614 CDS YP_001493717.1 157825997 5645483 complement(855694..856251) 1 NC_009881.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 856251 5645483 A1C_04745 Rickettsia akari str. Hartford peptidyl-tRNA hydrolase YP_001493717.1 855694 R 293614 CDS YP_001493718.1 157825998 5645484 complement(856484..857083) 1 NC_009881.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 857083 5645484 A1C_04750 Rickettsia akari str. Hartford 50S ribosomal protein L25 YP_001493718.1 856484 R 293614 CDS YP_001493719.1 157825999 5645485 complement(857455..858132) 1 NC_009881.1 COG0602 Organic radical activating enzymes; organic radical activating protein 858132 5645485 A1C_04755 Rickettsia akari str. Hartford organic radical activating protein YP_001493719.1 857455 R 293614 CDS YP_001493720.1 157826000 5645486 complement(858253..858387) 1 NC_009881.1 50S ribosomal protein L35 858387 rpmI 5645486 rpmI Rickettsia akari str. Hartford 50S ribosomal protein L35 YP_001493720.1 858253 R 293614 CDS YP_001493721.1 157826001 5645487 858749..858955 1 NC_009881.1 COG0291 Ribosomal protein L35; 50S ribosomal protein L35 858955 rpmI 5645487 rpmI Rickettsia akari str. Hartford 50S ribosomal protein L35 YP_001493721.1 858749 D 293614 CDS YP_001493722.1 157826002 5644735 858976..859329 1 NC_009881.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 859329 rplT 5644735 rplT Rickettsia akari str. Hartford 50S ribosomal protein L20 YP_001493722.1 858976 D 293614 CDS YP_001493723.1 157826003 5644736 859456..859590 1 NC_009881.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 859590 rpmH 5644736 rpmH Rickettsia akari str. Hartford 50S ribosomal protein L34 YP_001493723.1 859456 D 293614 CDS YP_001493724.1 157826004 5644737 859610..859966 1 NC_009881.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 859966 rnpA 5644737 rnpA Rickettsia akari str. Hartford ribonuclease P YP_001493724.1 859610 D 293614 CDS YP_001493725.1 157826005 5644738 complement(860414..860740) 1 NC_009881.1 hypothetical protein 860740 5644738 A1C_04785 Rickettsia akari str. Hartford hypothetical protein YP_001493725.1 860414 R 293614 CDS YP_001493726.1 157826006 5644739 complement(861045..861266) 1 NC_009881.1 hypothetical protein 861266 5644739 A1C_04790 Rickettsia akari str. Hartford hypothetical protein YP_001493726.1 861045 R 293614 CDS YP_001493727.1 157826007 5644740 complement(861315..861599) 1 NC_009881.1 hypothetical protein 861599 5644740 A1C_04795 Rickettsia akari str. Hartford hypothetical protein YP_001493727.1 861315 R 293614 CDS YP_001493728.1 157826008 5644741 complement(861612..861776) 1 NC_009881.1 hypothetical protein 861776 5644741 A1C_04800 Rickettsia akari str. Hartford hypothetical protein YP_001493728.1 861612 R 293614 CDS YP_001493729.1 157826009 5645796 complement(866172..866693) 1 NC_009881.1 COG3173 Predicted aminoglycoside phosphotransferase; acetyltransferase 866693 5645796 A1C_04815 Rickettsia akari str. Hartford acetyltransferase YP_001493729.1 866172 R 293614 CDS YP_001493730.1 157826010 5645797 complement(867123..868922) 1 NC_009881.1 COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation; nitrogen regulation protein NtrY 868922 5645797 A1C_04820 Rickettsia akari str. Hartford nitrogen regulation protein NtrY YP_001493730.1 867123 R 293614 CDS YP_001493731.1 157826011 5645798 complement(869215..869415) 1 NC_009881.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 869415 rpsU 5645798 rpsU Rickettsia akari str. Hartford 30S ribosomal protein S21 YP_001493731.1 869215 R 293614 CDS YP_001493732.1 157826012 5645799 869496..870104 1 NC_009881.1 COG5590 Uncharacterized conserved protein; hypothetical protein 870104 5645799 A1C_04830 Rickettsia akari str. Hartford hypothetical protein YP_001493732.1 869496 D 293614 CDS YP_001493733.1 157826013 5645800 complement(870118..870495) 1 NC_009881.1 COG1848 Predicted nucleic acid-binding protein, contains PIN domain; hypothetical protein 870495 5645800 A1C_04835 Rickettsia akari str. Hartford hypothetical protein YP_001493733.1 870118 R 293614 CDS YP_001493734.1 157826014 5645801 870809..874120 1 NC_009881.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 874120 ileS 5645801 ileS Rickettsia akari str. Hartford isoleucyl-tRNA synthetase YP_001493734.1 870809 D 293614 CDS YP_001493735.1 157826015 5645802 874204..874593 1 NC_009881.1 hypothetical protein 874593 5645802 A1C_04845 Rickettsia akari str. Hartford hypothetical protein YP_001493735.1 874204 D 293614 CDS YP_001493736.1 157826016 5644758 874942..875145 1 NC_009881.1 hypothetical protein 875145 5644758 A1C_04850 Rickettsia akari str. Hartford hypothetical protein YP_001493736.1 874942 D 293614 CDS YP_001493737.1 157826017 5644759 complement(875131..877128) 1 NC_009881.1 COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit; propionyl-CoA carboxylase subunit alpha 877128 5644759 A1C_04855 Rickettsia akari str. Hartford propionyl-CoA carboxylase subunit alpha YP_001493737.1 875131 R 293614 CDS YP_001493738.1 157826018 5644760 complement(877333..878877) 1 NC_009881.1 COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta); propionyl-CoA carboxylase subunit beta 878877 5644760 A1C_04860 Rickettsia akari str. Hartford propionyl-CoA carboxylase subunit beta YP_001493738.1 877333 R 293614 CDS YP_001493739.1 157826019 5644761 878951..879094 1 NC_009881.1 acylglycerophosphoethanolamine acyltransferase 879094 5644761 A1C_04865 Rickettsia akari str. Hartford acylglycerophosphoethanolamine acyltransferase YP_001493739.1 878951 D 293614 CDS YP_001493740.1 157826020 5644762 879156..879290 1 NC_009881.1 hypothetical protein 879290 5644762 A1C_04870 Rickettsia akari str. Hartford hypothetical protein YP_001493740.1 879156 D 293614 CDS YP_001493741.1 157826021 5644763 879448..882918 1 NC_009881.1 Synthesizes thioester adducts of fatty acids enzymatically to the phosphopantetheine group of acyl carrier protein; acylglycerophosphoethanolamine acyltransferase 882918 5644763 A1C_04875 Rickettsia akari str. Hartford acylglycerophosphoethanolamine acyltransferase YP_001493741.1 879448 D 293614 CDS YP_001493742.1 157826022 5644764 complement(883189..883458) 1 NC_009881.1 COG3070 Regulator of competence-specific genes; hypothetical protein 883458 5644764 A1C_04880 Rickettsia akari str. Hartford hypothetical protein YP_001493742.1 883189 R 293614 CDS YP_001493743.1 157826023 5644765 complement(883534..884295) 1 NC_009881.1 COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; Zinc/manganese ABC transporter permease protein 884295 5644765 A1C_04885 Rickettsia akari str. Hartford Zinc/manganese ABC transporter permease protein YP_001493743.1 883534 R 293614 CDS YP_001493744.1 157826024 5645636 884381..885136 1 NC_009881.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 885136 5645636 A1C_04890 Rickettsia akari str. Hartford 3-demethylubiquinone-9 3-methyltransferase YP_001493744.1 884381 D 293614 CDS YP_001493745.1 157826025 5645637 885207..886598 1 NC_009881.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 886598 gltX 5645637 gltX Rickettsia akari str. Hartford glutamyl-tRNA synthetase YP_001493745.1 885207 D 293614 CDS YP_001493746.1 157826026 5645638 886595..887161 1 NC_009881.1 COG5342 Invasion protein B, involved in pathogenesis; hypothetical protein 887161 5645638 A1C_04900 Rickettsia akari str. Hartford hypothetical protein YP_001493746.1 886595 D 293614 CDS YP_001493747.1 157826027 5645639 complement(887840..887983) 1 NC_009881.1 hypothetical protein 887983 5645639 A1C_04905 Rickettsia akari str. Hartford hypothetical protein YP_001493747.1 887840 R 293614 CDS YP_001493748.1 157826028 5645640 complement(889255..889596) 1 NC_009881.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; hypothetical protein 889596 5645640 A1C_04920 Rickettsia akari str. Hartford hypothetical protein YP_001493748.1 889255 R 293614 CDS YP_001493749.1 157826029 5645641 complement(890315..891961) 1 NC_009881.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 891961 groEL 5645641 groEL Rickettsia akari str. Hartford chaperonin GroEL YP_001493749.1 890315 R 293614 CDS YP_001493750.1 157826030 5645642 complement(891988..892275) 1 NC_009881.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 892275 groES 5645642 groES Rickettsia akari str. Hartford co-chaperonin GroES YP_001493750.1 891988 R 293614 CDS YP_001493751.1 157826031 5645643 complement(893672..893818) 1 NC_009881.1 hypothetical protein 893818 5645643 A1C_04945 Rickettsia akari str. Hartford hypothetical protein YP_001493751.1 893672 R 293614 CDS YP_001493752.1 157826032 5645875 complement(894478..895197) 1 NC_009881.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 895197 rph 5645875 rph Rickettsia akari str. Hartford ribonuclease PH YP_001493752.1 894478 R 293614 CDS YP_001493753.1 157826033 5645876 895325..895861 1 NC_009881.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 895861 5645876 A1C_04955 Rickettsia akari str. Hartford heat shock protein GrpE YP_001493753.1 895325 D 293614 CDS YP_001493754.1 157826034 5645877 896007..897062 1 NC_009881.1 COG0628 Predicted permease; hypothetical protein 897062 5645877 A1C_04960 Rickettsia akari str. Hartford hypothetical protein YP_001493754.1 896007 D 293614 CDS YP_001493755.1 157826035 5645878 897185..897853 1 NC_009881.1 COG0593 ATPase involved in DNA replication initiation; hypothetical protein 897853 5645878 A1C_04965 Rickettsia akari str. Hartford hypothetical protein YP_001493755.1 897185 D 293614 CDS YP_001493756.1 157826036 5645879 898319..898639 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; MFS type sugar transporter 898639 5645879 A1C_04970 Rickettsia akari str. Hartford MFS type sugar transporter YP_001493756.1 898319 D 293614 CDS YP_001493757.1 157826037 5645881 complement(899986..900258) 1 NC_009881.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 900258 rpsT 5645881 rpsT Rickettsia akari str. Hartford 30S ribosomal protein S20 YP_001493757.1 899986 R 293614 CDS YP_001493758.1 157826038 5645452 complement(900270..900686) 1 NC_009881.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 900686 rplQ 5645452 rplQ Rickettsia akari str. Hartford 50S ribosomal protein L17 YP_001493758.1 900270 R 293614 CDS YP_001493759.1 157826039 5645453 complement(900693..901715) 1 NC_009881.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 901715 5645453 A1C_04985 Rickettsia akari str. Hartford DNA-directed RNA polymerase subunit alpha YP_001493759.1 900693 R 293614 CDS YP_001493760.1 157826040 5645454 complement(901734..902117) 1 NC_009881.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 902117 5645454 A1C_04990 Rickettsia akari str. Hartford 30S ribosomal protein S11 YP_001493760.1 901734 R 293614 CDS YP_001493761.1 157826041 5645455 complement(902142..902519) 1 NC_009881.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 902519 rpsM 5645455 rpsM Rickettsia akari str. Hartford 30S ribosomal protein S13 YP_001493761.1 902142 R 293614 CDS YP_001493762.1 157826042 5645456 complement(902578..903216) 1 NC_009881.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 903216 adk 5645456 adk Rickettsia akari str. Hartford adenylate kinase YP_001493762.1 902578 R 293614 CDS YP_001493763.1 157826043 5645457 complement(903232..904533) 1 NC_009881.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 904533 secY 5645457 secY Rickettsia akari str. Hartford preprotein translocase subunit SecY YP_001493763.1 903232 R 293614 CDS YP_001493764.1 157826044 5645458 complement(904537..904998) 1 NC_009881.1 late assembly protein; 50S ribosomal protein L15 904998 rplO 5645458 rplO Rickettsia akari str. Hartford 50S ribosomal protein L15 YP_001493764.1 904537 R 293614 CDS YP_001493765.1 157826045 5645459 complement(905012..905203) 1 NC_009881.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 905203 rpmD 5645459 rpmD Rickettsia akari str. Hartford 50S ribosomal protein L30 YP_001493765.1 905012 R 293614 CDS YP_001493766.1 157826046 5644627 complement(905227..905757) 1 NC_009881.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 905757 rpsE 5644627 rpsE Rickettsia akari str. Hartford 30S ribosomal protein S5 YP_001493766.1 905227 R 293614 CDS YP_001493767.1 157826047 5644628 complement(905775..906131) 1 NC_009881.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 906131 rplR 5644628 rplR Rickettsia akari str. Hartford 50S ribosomal protein L18 YP_001493767.1 905775 R 293614 CDS YP_001493768.1 157826048 5644629 complement(906147..906680) 1 NC_009881.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 906680 rplF 5644629 rplF Rickettsia akari str. Hartford 50S ribosomal protein L6 YP_001493768.1 906147 R 293614 CDS YP_001493769.1 157826049 5644630 complement(906690..907088) 1 NC_009881.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 907088 rpsH 5644630 rpsH Rickettsia akari str. Hartford 30S ribosomal protein S8 YP_001493769.1 906690 R 293614 CDS YP_001493770.1 157826050 5644631 complement(907108..907413) 1 NC_009881.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 907413 rpsN 5644631 rpsN Rickettsia akari str. Hartford 30S ribosomal protein S14 YP_001493770.1 907108 R 293614 CDS YP_001493771.1 157826051 5644632 complement(907431..907970) 1 NC_009881.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 907970 rplE 5644632 rplE Rickettsia akari str. Hartford 50S ribosomal protein L5 YP_001493771.1 907431 R 293614 CDS YP_001493772.1 157826052 5644633 complement(907970..908299) 1 NC_009881.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 908299 rplX 5644633 rplX Rickettsia akari str. Hartford 50S ribosomal protein L24 YP_001493772.1 907970 R 293614 CDS YP_001493773.1 157826053 5644634 complement(908300..908668) 1 NC_009881.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 908668 rplN 5644634 rplN Rickettsia akari str. Hartford 50S ribosomal protein L14 YP_001493773.1 908300 R 293614 CDS YP_001493774.1 157826054 5645852 complement(908743..908976) 1 NC_009881.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 908976 rpsQ 5645852 rpsQ Rickettsia akari str. Hartford 30S ribosomal protein S17 YP_001493774.1 908743 R 293614 CDS YP_001493775.1 157826055 5645853 complement(908978..909193) 1 NC_009881.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 909193 rpmC 5645853 rpmC Rickettsia akari str. Hartford 50S ribosomal protein L29 YP_001493775.1 908978 R 293614 CDS YP_001493776.1 157826056 5645854 complement(909186..909596) 1 NC_009881.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 909596 rplP 5645854 rplP Rickettsia akari str. Hartford 50S ribosomal protein L16 YP_001493776.1 909186 R 293614 CDS YP_001493777.1 157826057 5645855 complement(909611..910264) 1 NC_009881.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 910264 rpsC 5645855 rpsC Rickettsia akari str. Hartford 30S ribosomal protein S3 YP_001493777.1 909611 R 293614 CDS YP_001493778.1 157826058 5645856 complement(910266..910625) 1 NC_009881.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 910625 rplV 5645856 rplV Rickettsia akari str. Hartford 50S ribosomal protein L22 YP_001493778.1 910266 R 293614 CDS YP_001493779.1 157826059 5645857 complement(910634..910912) 1 NC_009881.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 910912 rpsS 5645857 rpsS Rickettsia akari str. Hartford 30S ribosomal protein S19 YP_001493779.1 910634 R 293614 CDS YP_001493780.1 157826060 5645858 complement(910937..911758) 1 NC_009881.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 911758 rplB 5645858 rplB Rickettsia akari str. Hartford 50S ribosomal protein L2 YP_001493780.1 910937 R 293614 CDS YP_001493781.1 157826061 5645859 complement(911759..912055) 1 NC_009881.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 912055 rplW 5645859 rplW Rickettsia akari str. Hartford 50S ribosomal protein L23 YP_001493781.1 911759 R 293614 CDS YP_001493782.1 157826062 5645306 complement(912052..912675) 1 NC_009881.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 912675 rplD 5645306 rplD Rickettsia akari str. Hartford 50S ribosomal protein L4 YP_001493782.1 912052 R 293614 CDS YP_001493783.1 157826063 5645307 complement(912952..913599) 1 NC_009881.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 913599 rplC 5645307 rplC Rickettsia akari str. Hartford 50S ribosomal protein L3 YP_001493783.1 912952 R 293614 CDS YP_001493784.1 157826064 5645308 complement(913600..913917) 1 NC_009881.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 913917 rpsJ 5645308 rpsJ Rickettsia akari str. Hartford 30S ribosomal protein S10 YP_001493784.1 913600 R 293614 CDS YP_001493785.1 157826065 5645309 complement(914013..915200) 1 NC_009881.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 915200 5645309 A1C_05115 Rickettsia akari str. Hartford elongation factor Tu YP_001493785.1 914013 R 293614 CDS YP_001493786.1 157826066 5645312 915772..916506 1 NC_009881.1 COG0566 rRNA methylases; tRNA/rRNA methyltransferase 916506 5645312 A1C_05120 Rickettsia akari str. Hartford tRNA/rRNA methyltransferase YP_001493786.1 915772 D 293614 CDS YP_001493787.1 157826067 5644642 916727..917056 1 NC_009881.1 hypothetical protein 917056 5644642 A1C_05125 Rickettsia akari str. Hartford hypothetical protein YP_001493787.1 916727 D 293614 CDS YP_001493788.1 157826068 5644643 917053..918444 1 NC_009881.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 918444 fumC 5644643 fumC Rickettsia akari str. Hartford fumarate hydratase YP_001493788.1 917053 D 293614 CDS YP_001493789.1 157826069 5644644 918542..918790 1 NC_009881.1 COG4118 Antitoxin of toxin-antitoxin stability system; antitoxin of toxin-antitoxin system Phd 918790 5644644 A1C_05135 Rickettsia akari str. Hartford antitoxin of toxin-antitoxin system Phd YP_001493789.1 918542 D 293614 CDS YP_001493790.1 157826070 5644645 919059..919262 1 NC_009881.1 toxin of toxin-antitoxin system 919262 5644645 A1C_05140 Rickettsia akari str. Hartford toxin of toxin-antitoxin system YP_001493790.1 919059 D 293614 CDS YP_001493791.1 157826071 5644646 919450..920820 1 NC_009881.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 920820 5644646 A1C_05145 Rickettsia akari str. Hartford cell division protein FtsZ YP_001493791.1 919450 D 293614 CDS YP_001493792.1 157826072 5644647 920817..920936 1 NC_009881.1 hypothetical protein 920936 5644647 A1C_05150 Rickettsia akari str. Hartford hypothetical protein YP_001493792.1 920817 D 293614 CDS YP_001493793.1 157826073 5644648 921913..922047 1 NC_009881.1 COG4574 Serine protease inhibitor ecotin; ecotin 922047 5644648 A1C_05165 Rickettsia akari str. Hartford ecotin YP_001493793.1 921913 D 293614 CDS YP_001493794.1 157826074 5645387 complement(922305..922877) 1 NC_009881.1 COG0694 Thioredoxin-like proteins and domains; hypothetical protein 922877 5645387 A1C_05170 Rickettsia akari str. Hartford hypothetical protein YP_001493794.1 922305 R 293614 CDS YP_001493795.1 157826075 5645388 complement(922940..923773) 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; AmpG protein 923773 5645388 A1C_05175 Rickettsia akari str. Hartford AmpG protein YP_001493795.1 922940 R 293614 CDS YP_001493796.1 157826076 5645389 923835..923981 1 NC_009881.1 hypothetical protein 923981 5645389 A1C_05180 Rickettsia akari str. Hartford hypothetical protein YP_001493796.1 923835 D 293614 CDS YP_001493797.1 157826077 5645390 complement(924356..925588) 1 NC_009881.1 COG0513 Superfamily II DNA and RNA helicases; ATP-dependent RNA helicase RhlE 925588 5645390 A1C_05185 Rickettsia akari str. Hartford ATP-dependent RNA helicase RhlE YP_001493797.1 924356 R 293614 CDS YP_001493798.1 157826078 5645391 complement(926264..926476) 1 NC_009881.1 COG1278 Cold shock proteins; cold shock-like protein 926476 5645391 A1C_05190 Rickettsia akari str. Hartford cold shock-like protein YP_001493798.1 926264 R 293614 CDS YP_001493799.1 157826079 5645392 926593..926721 1 NC_009881.1 dimethyladenosine transferase 926721 ksgA 5645392 ksgA Rickettsia akari str. Hartford dimethyladenosine transferase YP_001493799.1 926593 D 293614 CDS YP_001493800.1 157826080 5645394 complement(927592..928413) 1 NC_009881.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 928413 ksgA 5645394 ksgA Rickettsia akari str. Hartford dimethyladenosine transferase YP_001493800.1 927592 R 293614 CDS YP_001493801.1 157826081 5644956 complement(928548..929438) 1 NC_009881.1 COG0760 Parvulin-like peptidyl-prolyl isomerase; hypothetical protein 929438 5644956 A1C_05205 Rickettsia akari str. Hartford hypothetical protein YP_001493801.1 928548 R 293614 CDS YP_001493802.1 157826082 5644957 complement(929606..931702) 1 NC_009881.1 COG1452 Organic solvent tolerance protein OstA; hypothetical protein 931702 5644957 A1C_05210 Rickettsia akari str. Hartford hypothetical protein YP_001493802.1 929606 R 293614 CDS YP_001493803.1 157826083 5644958 931713..931907 1 NC_009881.1 hypothetical protein 931907 5644958 A1C_05215 Rickettsia akari str. Hartford hypothetical protein YP_001493803.1 931713 D 293614 CDS YP_001493804.1 157826084 5644959 932036..933370 1 NC_009881.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 933370 xseA 5644959 xseA Rickettsia akari str. Hartford exodeoxyribonuclease VII large subunit YP_001493804.1 932036 D 293614 CDS YP_001493805.1 157826085 5644960 933449..935017 1 NC_009881.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; hypothetical protein 935017 5644960 A1C_05225 Rickettsia akari str. Hartford hypothetical protein YP_001493805.1 933449 D 293614 CDS YP_001493806.1 157826086 5644961 935014..935796 1 NC_009881.1 COG0708 Exonuclease III; exodeoxyribonuclease III 935796 5644961 A1C_05230 Rickettsia akari str. Hartford exodeoxyribonuclease III YP_001493806.1 935014 D 293614 CDS YP_001493807.1 157826087 5644962 935994..936260 1 NC_009881.1 COG4095 Uncharacterized conserved protein; hypothetical protein 936260 5644962 A1C_05235 Rickettsia akari str. Hartford hypothetical protein YP_001493807.1 935994 D 293614 CDS YP_001493808.1 157826088 5645372 936263..937606 1 NC_009881.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 937606 engA 5645372 engA Rickettsia akari str. Hartford GTP-binding protein EngA YP_001493808.1 936263 D 293614 CDS YP_001493809.1 157826089 5645373 complement(937614..937832) 1 NC_009881.1 COG1373 Predicted ATPase (AAA+ superfamily); ATPase 937832 5645373 A1C_05245 Rickettsia akari str. Hartford ATPase YP_001493809.1 937614 R 293614 CDS YP_001493810.1 157826090 5645374 complement(938210..938515) 1 NC_009881.1 hypothetical protein 938515 5645374 A1C_05250 Rickettsia akari str. Hartford hypothetical protein YP_001493810.1 938210 R 293614 CDS YP_001493811.1 157826091 5645375 938514..938696 1 NC_009881.1 hypothetical protein 938696 5645375 A1C_05255 Rickettsia akari str. Hartford hypothetical protein YP_001493811.1 938514 D 293614 CDS YP_001493812.1 157826092 5645376 complement(938746..940182) 1 NC_009881.1 COG0661 Predicted unusual protein kinase; 2-polyprenylphenol 6-hydroxylase 940182 5645376 A1C_05260 Rickettsia akari str. Hartford 2-polyprenylphenol 6-hydroxylase YP_001493812.1 938746 R 293614 CDS YP_001493813.1 157826093 5645377 complement(940179..940925) 1 NC_009881.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 940925 ubiE 5645377 ubiE Rickettsia akari str. Hartford ubiquinone/menaquinone biosynthesis methyltransferase YP_001493813.1 940179 R 293614 CDS YP_001493814.1 157826094 5645378 complement(941119..941274) 1 NC_009881.1 hypothetical protein 941274 5645378 A1C_05270 Rickettsia akari str. Hartford hypothetical protein YP_001493814.1 941119 R 293614 CDS YP_001493815.1 157826095 5645379 complement(941271..941336) 1 NC_009881.1 hypothetical protein 941336 5645379 A1C_05275 Rickettsia akari str. Hartford hypothetical protein YP_001493815.1 941271 R 293614 CDS YP_001493816.1 157826096 5645744 942402..942605 1 NC_009881.1 COG0836 Mannose-1-phosphate guanylyltransferase; hypothetical protein 942605 5645744 A1C_05290 Rickettsia akari str. Hartford hypothetical protein YP_001493816.1 942402 D 293614 CDS YP_001493817.1 157826097 5645745 943192..943683 1 NC_009881.1 COG0836 Mannose-1-phosphate guanylyltransferase; mannose-1-phosphate guanylyltransferase 943683 5645745 A1C_05295 Rickettsia akari str. Hartford mannose-1-phosphate guanylyltransferase YP_001493817.1 943192 D 293614 CDS YP_001493818.1 157826098 5645746 944152..944400 1 NC_009881.1 hypothetical protein 944400 5645746 A1C_05300 Rickettsia akari str. Hartford hypothetical protein YP_001493818.1 944152 D 293614 CDS YP_001493819.1 157826099 5645747 complement(944984..946237) 1 NC_009881.1 COG4553 Poly-beta-hydroxyalkanoate depolymerase; Poly-beta-hydroxyalkanoate depolymerase 946237 5645747 A1C_05305 Rickettsia akari str. Hartford Poly-beta-hydroxyalkanoate depolymerase YP_001493819.1 944984 R 293614 CDS YP_001493820.1 157826100 5645748 complement(947144..947380) 1 NC_009881.1 hypothetical protein 947380 5645748 A1C_05320 Rickettsia akari str. Hartford hypothetical protein YP_001493820.1 947144 R 293614 CDS YP_001493821.1 157826101 5645749 complement(947655..948404) 1 NC_009881.1 COG0084 Mg-dependent DNase; deoxyribonuclease 948404 5645749 A1C_05325 Rickettsia akari str. Hartford deoxyribonuclease YP_001493821.1 947655 R 293614 CDS YP_001493822.1 157826102 5645750 complement(948688..950226) 1 NC_009881.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 950226 5645750 A1C_05330 Rickettsia akari str. Hartford methionyl-tRNA synthetase YP_001493822.1 948688 R 293614 CDS YP_001493823.1 157826103 5645751 complement(950223..950834) 1 NC_009881.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 950834 tmk 5645751 tmk Rickettsia akari str. Hartford thymidylate kinase YP_001493823.1 950223 R 293614 CDS YP_001493824.1 157826104 5645424 951095..952375 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; proline/betaine transporter 952375 5645424 A1C_05340 Rickettsia akari str. Hartford proline/betaine transporter YP_001493824.1 951095 D 293614 CDS YP_001493825.1 157826105 5645425 complement(952630..953472) 1 NC_009881.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; 4-hydroxybenzoate polyprenyltransferase 953472 ubiA 5645425 ubiA Rickettsia akari str. Hartford 4-hydroxybenzoate polyprenyltransferase YP_001493825.1 952630 R 293614 CDS YP_001493826.1 157826106 5645426 954786..957224 1 NC_009881.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 957224 valS 5645426 valS Rickettsia akari str. Hartford valyl-tRNA synthetase YP_001493826.1 954786 D 293614 CDS YP_001493827.1 157826107 5645427 959496..960782 1 NC_009881.1 COG1322 Uncharacterized protein conserved in bacteria; hypothetical protein 960782 5645427 A1C_05400 Rickettsia akari str. Hartford hypothetical protein YP_001493827.1 959496 D 293614 CDS YP_001493828.1 157826108 5645428 complement(960943..961119) 1 NC_009881.1 hypothetical protein 961119 5645428 A1C_05405 Rickettsia akari str. Hartford hypothetical protein YP_001493828.1 960943 R 293614 CDS YP_001493829.1 157826109 5645429 complement(961311..961763) 1 NC_009881.1 hypothetical protein 961763 5645429 A1C_05410 Rickettsia akari str. Hartford hypothetical protein YP_001493829.1 961311 R 293614 CDS YP_001493830.1 157826110 5645430 complement(961735..962040) 1 NC_009881.1 hypothetical protein 962040 5645430 A1C_05415 Rickettsia akari str. Hartford hypothetical protein YP_001493830.1 961735 R 293614 CDS YP_001493831.1 157826111 5645431 complement(962388..962729) 1 NC_009881.1 hypothetical protein 962729 5645431 A1C_05420 Rickettsia akari str. Hartford hypothetical protein YP_001493831.1 962388 R 293614 CDS YP_001493832.1 157826112 5645830 963899..963985 1 NC_009881.1 hypothetical protein 963985 5645830 A1C_05435 Rickettsia akari str. Hartford hypothetical protein YP_001493832.1 963899 D 293614 CDS YP_001493833.1 157826113 5645831 963986..964234 1 NC_009881.1 hypothetical protein 964234 5645831 A1C_05440 Rickettsia akari str. Hartford hypothetical protein YP_001493833.1 963986 D 293614 CDS YP_001493834.1 157826114 5645832 complement(964545..965822) 1 NC_009881.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 965822 clpX 5645832 clpX Rickettsia akari str. Hartford ATP-dependent protease ATP-binding subunit ClpX YP_001493834.1 964545 R 293614 CDS YP_001493835.1 157826115 5645833 complement(965889..966440) 1 NC_009881.1 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; ribosomal-protein-alanine acetyltransferase 966440 5645833 A1C_05450 Rickettsia akari str. Hartford ribosomal-protein-alanine acetyltransferase YP_001493835.1 965889 R 293614 CDS YP_001493836.1 157826116 5645834 complement(966574..967257) 1 NC_009881.1 COG0603 Predicted PP-loop superfamily ATPase; trans-regulatory protein ExsB 967257 5645834 A1C_05455 Rickettsia akari str. Hartford trans-regulatory protein ExsB YP_001493836.1 966574 R 293614 CDS YP_001493837.1 157826117 5645835 complement(967232..967345) 1 NC_009881.1 hypothetical protein 967345 5645835 A1C_05460 Rickettsia akari str. Hartford hypothetical protein YP_001493837.1 967232 R 293614 CDS YP_001493838.1 157826118 5645836 complement(967463..967597) 1 NC_009881.1 COG1598 Uncharacterized conserved protein; hypothetical protein 967597 5645836 A1C_05465 Rickettsia akari str. Hartford hypothetical protein YP_001493838.1 967463 R 293614 CDS YP_001493839.1 157826119 5645837 complement(967620..967751) 1 NC_009881.1 hypothetical protein 967751 5645837 A1C_05470 Rickettsia akari str. Hartford hypothetical protein YP_001493839.1 967620 R 293614 CDS YP_001493840.1 157826120 5645125 968152..969858 1 NC_009881.1 COG1132 ABC-type multidrug transport system, ATPase and permease components; multidrug resistance protein 969858 5645125 A1C_05475 Rickettsia akari str. Hartford multidrug resistance protein YP_001493840.1 968152 D 293614 CDS YP_001493841.1 157826121 5645126 970187..970435 1 NC_009881.1 hypothetical protein 970435 5645126 A1C_05480 Rickettsia akari str. Hartford hypothetical protein YP_001493841.1 970187 D 293614 CDS YP_001493842.1 157826122 5645127 970979..972154 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; bicyclomycin resistance protein 972154 5645127 A1C_05485 Rickettsia akari str. Hartford bicyclomycin resistance protein YP_001493842.1 970979 D 293614 CDS YP_001493843.1 157826123 5645128 972263..973510 1 NC_009881.1 COG4591 ABC-type transport system, involved in lipoprotein release, permease component; lipoprotein releasing system, transmembrane protein 973510 5645128 A1C_05490 Rickettsia akari str. Hartford lipoprotein releasing system, transmembrane protein YP_001493843.1 972263 D 293614 CDS YP_001493844.1 157826124 5645129 973503..974168 1 NC_009881.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component; lipoprotein releasing system ATP-binding protein LolD 974168 5645129 A1C_05495 Rickettsia akari str. Hartford lipoprotein releasing system ATP-binding protein LolD YP_001493844.1 973503 D 293614 CDS YP_001493845.1 157826125 5645130 974225..975223 1 NC_009881.1 hypothetical protein 975223 5645130 A1C_05500 Rickettsia akari str. Hartford hypothetical protein YP_001493845.1 974225 D 293614 CDS YP_001493846.1 157826126 5644984 975990..976112 1 NC_009881.1 hypothetical protein 976112 5644984 A1C_05505 Rickettsia akari str. Hartford hypothetical protein YP_001493846.1 975990 D 293614 CDS YP_001493847.1 157826127 5644985 976332..977597 1 NC_009881.1 COG4536 Putative Mg2+ and Co2+ transporter CorB; hypothetical protein 977597 5644985 A1C_05510 Rickettsia akari str. Hartford hypothetical protein YP_001493847.1 976332 D 293614 CDS YP_001493848.1 157826128 5644986 977911..979569 1 NC_009881.1 COG1138 Cytochrome c biogenesis factor; cytochrome c-type biogenesis protein CcmF 979569 5644986 A1C_05515 Rickettsia akari str. Hartford cytochrome c-type biogenesis protein CcmF YP_001493848.1 977911 D 293614 CDS YP_001493849.1 157826129 5644987 complement(980178..980294) 1 NC_009881.1 hypothetical protein 980294 5644987 A1C_05530 Rickettsia akari str. Hartford hypothetical protein YP_001493849.1 980178 R 293614 CDS YP_001493850.1 157826130 5644988 complement(981137..986113) 1 NC_009881.1 COG4625 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain; Outer membrane protein B 986113 5644988 A1C_05535 Rickettsia akari str. Hartford Outer membrane protein B YP_001493850.1 981137 R 293614 CDS YP_001493851.1 157826131 5644989 complement(986442..987047) 1 NC_009881.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; guanosine polyphosphate pyrophosphohydrolase/synthetase-like protein 987047 5644989 A1C_05540 Rickettsia akari str. Hartford guanosine polyphosphate pyrophosphohydrolase/synthetase-like protein YP_001493851.1 986442 R 293614 CDS YP_001493852.1 157826132 5644990 complement(987469..988458) 1 NC_009881.1 COG1472 Beta-glucosidase-related glycosidases; Beta-glucosidase 988458 5644990 A1C_05545 Rickettsia akari str. Hartford Beta-glucosidase YP_001493852.1 987469 R 293614 CDS YP_001493853.1 157826133 5644991 complement(988511..988807) 1 NC_009881.1 COG0789 Predicted transcriptional regulators; hypothetical protein 988807 5644991 A1C_05550 Rickettsia akari str. Hartford hypothetical protein YP_001493853.1 988511 R 293614 CDS YP_001493854.1 157826134 5645067 complement(988794..989084) 1 NC_009881.1 COG0776 Bacterial nucleoid DNA-binding protein; integration host factor alpha-subunit 989084 5645067 A1C_05555 Rickettsia akari str. Hartford integration host factor alpha-subunit YP_001493854.1 988794 R 293614 CDS YP_001493855.1 157826135 5645068 complement(989167..989628) 1 NC_009881.1 hypothetical protein 989628 5645068 A1C_05560 Rickettsia akari str. Hartford hypothetical protein YP_001493855.1 989167 R 293614 CDS YP_001493856.1 157826136 5645069 990085..990555 1 NC_009881.1 COG1225 Peroxiredoxin; bacterioferritin comigratory protein 990555 5645069 A1C_05565 Rickettsia akari str. Hartford bacterioferritin comigratory protein YP_001493856.1 990085 D 293614 CDS YP_001493857.1 157826137 5645070 complement(990657..991529) 1 NC_009881.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 991529 5645070 A1C_05570 Rickettsia akari str. Hartford lipid A biosynthesis lauroyl acyltransferase YP_001493857.1 990657 R 293614 CDS YP_001493858.1 157826138 5645071 complement(991492..992469) 1 NC_009881.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 992469 lpxK 5645071 lpxK Rickettsia akari str. Hartford tetraacyldisaccharide 4'-kinase YP_001493858.1 991492 R 293614 CDS YP_001493859.1 157826139 5645072 complement(992692..993597) 1 NC_009881.1 COG0739 Membrane proteins related to metalloendopeptidases; hypothetical protein 993597 5645072 A1C_05580 Rickettsia akari str. Hartford hypothetical protein YP_001493859.1 992692 R 293614 CDS YP_001493860.1 157826140 5645073 complement(993546..994334) 1 NC_009881.1 COG2961 Protein involved in catabolism of external DNA; hypothetical protein 994334 5645073 A1C_05585 Rickettsia akari str. Hartford hypothetical protein YP_001493860.1 993546 R 293614 CDS YP_001493861.1 157826141 5645074 complement(994573..994665) 1 NC_009881.1 NAD-dependent DNA ligase LigA 994665 ligA 5645074 ligA Rickettsia akari str. Hartford NAD-dependent DNA ligase LigA YP_001493861.1 994573 R 293614 CDS YP_001493862.1 157826142 5644750 complement(994917..996986) 1 NC_009881.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 996986 ligA 5644750 ligA Rickettsia akari str. Hartford NAD-dependent DNA ligase LigA YP_001493862.1 994917 R 293614 CDS YP_001493863.1 157826143 5644751 complement(996973..997167) 1 NC_009881.1 hypothetical protein 997167 5644751 A1C_05600 Rickettsia akari str. Hartford hypothetical protein YP_001493863.1 996973 R 293614 CDS YP_001493864.1 157826144 5644752 complement(997168..997395) 1 NC_009881.1 COG2161 Antitoxin of toxin-antitoxin stability system; prevent-host-death family protein 997395 5644752 A1C_05605 Rickettsia akari str. Hartford prevent-host-death family protein YP_001493864.1 997168 R 293614 CDS YP_001493865.1 157826145 5644753 complement(997444..998529) 1 NC_009881.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 998529 tgt 5644753 tgt Rickettsia akari str. Hartford queuine tRNA-ribosyltransferase YP_001493865.1 997444 R 293614 CDS YP_001493866.1 157826146 5644754 complement(998763..999047) 1 NC_009881.1 hypothetical protein 999047 5644754 A1C_05615 Rickettsia akari str. Hartford hypothetical protein YP_001493866.1 998763 R 293614 CDS YP_001493867.1 157826147 5644755 999325..999447 1 NC_009881.1 hypothetical protein 999447 5644755 A1C_05620 Rickettsia akari str. Hartford hypothetical protein YP_001493867.1 999325 D 293614 CDS YP_001493868.1 157826148 5644756 complement(999949..1001256) 1 NC_009881.1 hypothetical protein 1001256 5644756 A1C_05625 Rickettsia akari str. Hartford hypothetical protein YP_001493868.1 999949 R 293614 CDS YP_001493869.1 157826149 5644757 complement(1001597..1002934) 1 NC_009881.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1002934 trmE 5644757 trmE Rickettsia akari str. Hartford tRNA modification GTPase TrmE YP_001493869.1 1001597 R 293614 CDS YP_001493870.1 157826150 5645488 1003006..1007754 1 NC_009881.1 COG2902 NAD-specific glutamate dehydrogenase; NAD-specific glutamate dehydrogenase 1007754 5645488 A1C_05635 Rickettsia akari str. Hartford NAD-specific glutamate dehydrogenase YP_001493870.1 1003006 D 293614 CDS YP_001493871.1 157826151 5645489 1008135..1008338 1 NC_009881.1 hypothetical protein 1008338 5645489 A1C_05640 Rickettsia akari str. Hartford hypothetical protein YP_001493871.1 1008135 D 293614 CDS YP_001493872.1 157826152 5645490 1008341..1008658 1 NC_009881.1 COG3027 Uncharacterized protein conserved in bacteria; hypothetical protein 1008658 5645490 A1C_05645 Rickettsia akari str. Hartford hypothetical protein YP_001493872.1 1008341 D 293614 CDS YP_001493873.1 157826153 5645491 1008636..1008758 1 NC_009881.1 hypothetical protein 1008758 5645491 A1C_05650 Rickettsia akari str. Hartford hypothetical protein YP_001493873.1 1008636 D 293614 CDS YP_001493874.1 157826154 5645492 1009019..1010290 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; proline/betaine transporter 1010290 5645492 A1C_05655 Rickettsia akari str. Hartford proline/betaine transporter YP_001493874.1 1009019 D 293614 CDS YP_001493875.1 157826155 5645493 1010392..1010643 1 NC_009881.1 transcriptional regulator 1010643 5645493 A1C_05660 Rickettsia akari str. Hartford transcriptional regulator YP_001493875.1 1010392 D 293614 CDS YP_001493876.1 157826156 5645494 1010624..1010776 1 NC_009881.1 PilT domain-containing protein 1010776 5645494 A1C_05665 Rickettsia akari str. Hartford PilT domain-containing protein YP_001493876.1 1010624 D 293614 CDS YP_001493877.1 157826157 5645495 complement(1011233..1011487) 1 NC_009881.1 COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; hypothetical protein 1011487 5645495 A1C_05670 Rickettsia akari str. Hartford hypothetical protein YP_001493877.1 1011233 R 293614 CDS YP_001493878.1 157826158 5644794 complement(1011534..1011869) 1 NC_009881.1 COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; hypothetical protein 1011869 5644794 A1C_05675 Rickettsia akari str. Hartford hypothetical protein YP_001493878.1 1011534 R 293614 CDS YP_001493879.1 157826159 5644795 complement(1011960..1012454) 1 NC_009881.1 COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains; hypothetical protein 1012454 5644795 A1C_05680 Rickettsia akari str. Hartford hypothetical protein YP_001493879.1 1011960 R 293614 CDS YP_001493880.1 157826160 5644796 complement(1012866..1014071) 1 NC_009881.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 1014071 5644796 A1C_05685 Rickettsia akari str. Hartford aspartate kinase YP_001493880.1 1012866 R 293614 CDS YP_001493881.1 157826161 5644797 complement(1014313..1014573) 1 NC_009881.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1014573 rpmA 5644797 rpmA Rickettsia akari str. Hartford 50S ribosomal protein L27 YP_001493881.1 1014313 R 293614 CDS YP_001493882.1 157826162 5644798 complement(1014598..1014915) 1 NC_009881.1 COG0261 Ribosomal protein L21; 50S ribosomal protein L21 1014915 rplU 5644798 rplU Rickettsia akari str. Hartford 50S ribosomal protein L21 YP_001493882.1 1014598 R 293614 CDS YP_001493883.1 157826163 5644799 complement(1015132..1015734) 1 NC_009881.1 COG1267 Phosphatidylglycerophosphatase A and related proteins; phosphatidylglycerophosphatase A 1015734 5644799 A1C_05700 Rickettsia akari str. Hartford phosphatidylglycerophosphatase A YP_001493883.1 1015132 R 293614 CDS YP_001493884.1 157826164 5644800 1015813..1015974 1 NC_009881.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 1015974 tatA 5644800 tatA Rickettsia akari str. Hartford twin arginine translocase protein A YP_001493884.1 1015813 D 293614 CDS YP_001493885.1 157826165 5644801 complement(1016097..1017119) 1 NC_009881.1 ABC transporter substrate-binding protein 1017119 5644801 A1C_05710 Rickettsia akari str. Hartford ABC transporter substrate-binding protein YP_001493885.1 1016097 R 293614 CDS YP_001493886.1 157826166 5645351 1017240..1018076 1 NC_009881.1 COG0313 Predicted methyltransferases; hypothetical protein 1018076 5645351 A1C_05715 Rickettsia akari str. Hartford hypothetical protein YP_001493886.1 1017240 D 293614 CDS YP_001493887.1 157826167 5645352 1018414..1018503 1 NC_009881.1 hypothetical protein 1018503 5645352 A1C_05720 Rickettsia akari str. Hartford hypothetical protein YP_001493887.1 1018414 D 293614 CDS YP_001493888.1 157826168 5645353 1018958..1019065 1 NC_009881.1 hypothetical protein 1019065 5645353 A1C_05725 Rickettsia akari str. Hartford hypothetical protein YP_001493888.1 1018958 D 293614 CDS YP_001493889.1 157826169 5645354 complement(1019148..1019399) 1 NC_009881.1 COG5510 Predicted small secreted protein; hypothetical protein 1019399 5645354 A1C_05730 Rickettsia akari str. Hartford hypothetical protein YP_001493889.1 1019148 R 293614 CDS YP_001493890.1 157826170 5645355 complement(1019479..1020165) 1 NC_009881.1 COG0177 Predicted EndoIII-related endonuclease; endonuclease III 1020165 5645355 A1C_05735 Rickettsia akari str. Hartford endonuclease III YP_001493890.1 1019479 R 293614 CDS YP_001493891.1 157826171 5645356 1020215..1020529 1 NC_009881.1 COG0278 Glutaredoxin-related protein; glutaredoxin-like protein grla 1020529 5645356 A1C_05740 Rickettsia akari str. Hartford glutaredoxin-like protein grla YP_001493891.1 1020215 D 293614 CDS YP_001493892.1 157826172 5645357 1020641..1021285 1 NC_009881.1 COG0400 Predicted esterase; Serine esterase 1021285 5645357 A1C_05745 Rickettsia akari str. Hartford Serine esterase YP_001493892.1 1020641 D 293614 CDS YP_001493893.1 157826173 5645358 1021347..1021541 1 NC_009881.1 hypothetical protein 1021541 5645358 A1C_05750 Rickettsia akari str. Hartford hypothetical protein YP_001493893.1 1021347 D 293614 CDS YP_001493894.1 157826174 5645817 1021547..1021672 1 NC_009881.1 DNA modification methylase 1021672 5645817 A1C_05755 Rickettsia akari str. Hartford DNA modification methylase YP_001493894.1 1021547 D 293614 CDS YP_001493895.1 157826175 5645818 1021800..1021934 1 NC_009881.1 COG0863 DNA modification methylase; DNA modification methylase-like protein 1021934 5645818 A1C_05760 Rickettsia akari str. Hartford DNA modification methylase-like protein YP_001493895.1 1021800 D 293614 CDS YP_001493896.1 157826176 5645819 1022193..1022354 1 NC_009881.1 hypothetical protein 1022354 5645819 A1C_05765 Rickettsia akari str. Hartford hypothetical protein YP_001493896.1 1022193 D 293614 CDS YP_001493897.1 157826177 5645820 1022369..1023631 1 NC_009881.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 1023631 glyA 5645820 glyA Rickettsia akari str. Hartford serine hydroxymethyltransferase YP_001493897.1 1022369 D 293614 CDS YP_001493898.1 157826178 5645821 1023624..1024517 1 NC_009881.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 1024517 5645821 A1C_05775 Rickettsia akari str. Hartford lipoyl synthase YP_001493898.1 1023624 D 293614 CDS YP_001493899.1 157826179 5645822 1024757..1024987 1 NC_009881.1 hypothetical protein 1024987 5645822 A1C_05780 Rickettsia akari str. Hartford hypothetical protein YP_001493899.1 1024757 D 293614 CDS YP_001493900.1 157826180 5645823 1024974..1025294 1 NC_009881.1 COG2337 Growth inhibitor; PemK-like growth inhibitor 1025294 5645823 A1C_05785 Rickettsia akari str. Hartford PemK-like growth inhibitor YP_001493900.1 1024974 D 293614 CDS YP_001493901.1 157826181 5645824 1025321..1025824 1 NC_009881.1 COG0319 Predicted metal-dependent hydrolase; putative metalloprotease 1025824 5645824 A1C_05790 Rickettsia akari str. Hartford putative metalloprotease YP_001493901.1 1025321 D 293614 CDS YP_001493902.1 157826182 5644786 1025841..1026746 1 NC_009881.1 COG1253 Hemolysins and related proteins containing CBS domains; hemolysin C 1026746 5644786 A1C_05795 Rickettsia akari str. Hartford hemolysin C YP_001493902.1 1025841 D 293614 CDS YP_001493903.1 157826183 5644787 complement(1026808..1026924) 1 NC_009881.1 hypothetical protein 1026924 5644787 A1C_05800 Rickettsia akari str. Hartford hypothetical protein YP_001493903.1 1026808 R 293614 CDS YP_001493904.1 157826184 5644788 complement(1027209..1027406) 1 NC_009881.1 COG1943 Transposase and inactivated derivatives; transposase IS200-family protein 1027406 5644788 A1C_05805 Rickettsia akari str. Hartford transposase IS200-family protein YP_001493904.1 1027209 R 293614 CDS YP_001493905.1 157826185 5644789 complement(1028688..1030130) 1 NC_009881.1 COG3202 ATP/ADP translocase; ADP,ATP carrier protein 1030130 5644789 A1C_05810 Rickettsia akari str. Hartford ADP,ATP carrier protein YP_001493905.1 1028688 R 293614 CDS YP_001493906.1 157826186 5644790 1030648..1031613 1 NC_009881.1 COG3243 Poly(3-hydroxyalkanoate) synthetase; Poly-beta-hydroxybutyrate polymerase 1031613 5644790 A1C_05815 Rickettsia akari str. Hartford Poly-beta-hydroxybutyrate polymerase YP_001493906.1 1030648 D 293614 CDS YP_001493907.1 157826187 5644791 1031762..1032940 1 NC_009881.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 1032940 5644791 A1C_05820 Rickettsia akari str. Hartford acetyl-CoA acetyltransferase YP_001493907.1 1031762 D 293614 CDS YP_001493908.1 157826188 5644792 complement(1033207..1033617) 1 NC_009881.1 hypothetical protein 1033617 5644792 A1C_05825 Rickettsia akari str. Hartford hypothetical protein YP_001493908.1 1033207 R 293614 CDS YP_001493909.1 157826189 5644793 1034054..1034269 1 NC_009881.1 hypothetical protein 1034269 5644793 A1C_05830 Rickettsia akari str. Hartford hypothetical protein YP_001493909.1 1034054 D 293614 CDS YP_001493910.1 157826190 5644743 1034961..1035242 1 NC_009881.1 hypothetical protein 1035242 5644743 A1C_05835 Rickettsia akari str. Hartford hypothetical protein YP_001493910.1 1034961 D 293614 CDS YP_001493911.1 157826191 5644745 complement(1035829..1036053) 1 NC_009881.1 hypothetical protein 1036053 5644745 A1C_05840 Rickettsia akari str. Hartford hypothetical protein YP_001493911.1 1035829 R 293614 CDS YP_001493912.1 157826192 5644746 complement(1036650..1037594) 1 NC_009881.1 COG0331 (acyl-carrier-protein) S-malonyltransferase; acyl-carrier-protein S-malonyltransferase 1037594 5644746 A1C_05845 Rickettsia akari str. Hartford acyl-carrier-protein S-malonyltransferase YP_001493912.1 1036650 R 293614 CDS YP_001493913.1 157826193 5644747 complement(1039676..1042132) 1 NC_009881.1 COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); ATP-dependent helicase 1042132 5644747 A1C_05850 Rickettsia akari str. Hartford ATP-dependent helicase YP_001493913.1 1039676 R 293614 CDS YP_001493914.1 157826194 5644748 complement(1042184..1042804) 1 NC_009881.1 COG3346 Uncharacterized conserved protein; surfeit locus protein 1 1042804 5644748 A1C_05855 Rickettsia akari str. Hartford surfeit locus protein 1 YP_001493914.1 1042184 R 293614 CDS YP_001493915.1 157826195 5644749 complement(1043059..1043748) 1 NC_009881.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 1043748 5644749 A1C_05860 Rickettsia akari str. Hartford DNA polymerase III subunit epsilon YP_001493915.1 1043059 R 293614 CDS YP_001493916.1 157826196 5645045 complement(1043994..1044569) 1 NC_009881.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 1044569 coaE 5645045 coaE Rickettsia akari str. Hartford dephospho-CoA kinase YP_001493916.1 1043994 R 293614 CDS YP_001493917.1 157826197 5645046 complement(1044563..1045375) 1 NC_009881.1 COG3494 Uncharacterized protein conserved in bacteria; hypothetical protein 1045375 5645046 A1C_05870 Rickettsia akari str. Hartford hypothetical protein YP_001493917.1 1044563 R 293614 CDS YP_001493918.1 157826198 5645047 1046159..1046632 1 NC_009881.1 COG3814 Uncharacterized protein conserved in bacteria; hypothetical protein 1046632 5645047 A1C_05875 Rickettsia akari str. Hartford hypothetical protein YP_001493918.1 1046159 D 293614 CDS YP_001493919.1 157826199 5645048 1046642..1047100 1 NC_009881.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 1047100 rnhA 5645048 rnhA Rickettsia akari str. Hartford ribonuclease H YP_001493919.1 1046642 D 293614 CDS YP_001493920.1 157826200 5645049 1047088..1047387 1 NC_009881.1 COG3761 NADH:ubiquinone oxidoreductase 17.2 kD subunit; hypothetical protein 1047387 5645049 A1C_05885 Rickettsia akari str. Hartford hypothetical protein YP_001493920.1 1047088 D 293614 CDS YP_001493921.1 157826201 5645050 1047456..1047905 1 NC_009881.1 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component; ABC transporter substrate binding protein 1047905 5645050 A1C_05890 Rickettsia akari str. Hartford ABC transporter substrate binding protein YP_001493921.1 1047456 D 293614 CDS YP_001493922.1 157826202 5645051 1048256..1048351 1 NC_009881.1 hypothetical protein 1048351 5645051 A1C_05895 Rickettsia akari str. Hartford hypothetical protein YP_001493922.1 1048256 D 293614 CDS YP_001493923.1 157826203 5645052 1048480..1048665 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; MFS type sugar transporter 1048665 5645052 A1C_05900 Rickettsia akari str. Hartford MFS type sugar transporter YP_001493923.1 1048480 D 293614 CDS YP_001493924.1 157826204 5645504 complement(1049147..1049482) 1 NC_009881.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; hypothetical protein 1049482 5645504 A1C_05905 Rickettsia akari str. Hartford hypothetical protein YP_001493924.1 1049147 R 293614 CDS YP_001493925.1 157826205 5645505 complement(1049492..1049626) 1 NC_009881.1 hypothetical protein 1049626 5645505 A1C_05910 Rickettsia akari str. Hartford hypothetical protein YP_001493925.1 1049492 R 293614 CDS YP_001493926.1 157826206 5645506 complement(1051217..1051399) 1 NC_009881.1 hypothetical protein 1051399 5645506 A1C_05915 Rickettsia akari str. Hartford hypothetical protein YP_001493926.1 1051217 R 293614 CDS YP_001493927.1 157826207 5645507 complement(1051517..1051963) 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; hypothetical protein 1051963 5645507 A1C_05920 Rickettsia akari str. Hartford hypothetical protein YP_001493927.1 1051517 R 293614 CDS YP_001493928.1 157826208 5645508 complement(1052410..1052547) 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; hypothetical protein 1052547 5645508 A1C_05925 Rickettsia akari str. Hartford hypothetical protein YP_001493928.1 1052410 R 293614 CDS YP_001493929.1 157826209 5645509 1052846..1053934 1 NC_009881.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1053934 recA 5645509 recA Rickettsia akari str. Hartford recombinase A YP_001493929.1 1052846 D 293614 CDS YP_001493930.1 157826210 5645510 1053927..1054652 1 NC_009881.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1054652 fabG 5645510 fabG Rickettsia akari str. Hartford 3-ketoacyl-ACP reductase YP_001493930.1 1053927 D 293614 CDS YP_001493931.1 157826211 5645511 1054818..1055063 1 NC_009881.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1055063 acpP 5645511 acpP Rickettsia akari str. Hartford acyl carrier protein YP_001493931.1 1054818 D 293614 CDS YP_001493932.1 157826212 5645262 1055099..1056379 1 NC_009881.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1056379 5645262 A1C_05945 Rickettsia akari str. Hartford 3-oxoacyl-ACP synthase YP_001493932.1 1055099 D 293614 CDS YP_001493933.1 157826213 5645263 1057827..1058924 1 NC_009881.1 hypothetical protein 1058924 5645263 A1C_05960 Rickettsia akari str. Hartford hypothetical protein YP_001493933.1 1057827 D 293614 CDS YP_001493934.1 157826214 5645264 1058954..1059190 1 NC_009881.1 hypothetical protein 1059190 5645264 A1C_05965 Rickettsia akari str. Hartford hypothetical protein YP_001493934.1 1058954 D 293614 CDS YP_001493935.1 157826215 5645265 complement(1059564..1059752) 1 NC_009881.1 COG1373 Predicted ATPase (AAA+ superfamily); ATPase 1059752 5645265 A1C_05970 Rickettsia akari str. Hartford ATPase YP_001493935.1 1059564 R 293614 CDS YP_001493936.1 157826216 5645266 complement(1059745..1059927) 1 NC_009881.1 COG1373 Predicted ATPase (AAA+ superfamily); hypothetical protein 1059927 5645266 A1C_05975 Rickettsia akari str. Hartford hypothetical protein YP_001493936.1 1059745 R 293614 CDS YP_001493937.1 157826217 5645267 complement(1060116..1060235) 1 NC_009881.1 COG1373 Predicted ATPase (AAA+ superfamily); ATPase 1060235 5645267 A1C_05980 Rickettsia akari str. Hartford ATPase YP_001493937.1 1060116 R 293614 CDS YP_001493938.1 157826218 5645268 complement(1060517..1061095) 1 NC_009881.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1061095 gmk 5645268 gmk Rickettsia akari str. Hartford guanylate kinase YP_001493938.1 1060517 R 293614 CDS YP_001493939.1 157826219 5645269 complement(1061224..1061460) 1 NC_009881.1 COG1396 Predicted transcriptional regulators; hypothetical protein 1061460 5645269 A1C_05990 Rickettsia akari str. Hartford hypothetical protein YP_001493939.1 1061224 R 293614 CDS YP_001493940.1 157826220 5644678 complement(1062033..1062872) 1 NC_009881.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 1062872 5644678 A1C_05995 Rickettsia akari str. Hartford rod shape-determining protein MreC YP_001493940.1 1062033 R 293614 CDS YP_001493941.1 157826221 5644679 complement(1062875..1063915) 1 NC_009881.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 1063915 5644679 A1C_06000 Rickettsia akari str. Hartford rod shape-determining protein MreB YP_001493941.1 1062875 R 293614 CDS YP_001493942.1 157826222 5644680 complement(1064125..1065213) 1 NC_009881.1 COG0795 Predicted permeases; hypothetical protein 1065213 5644680 A1C_06005 Rickettsia akari str. Hartford hypothetical protein YP_001493942.1 1064125 R 293614 CDS YP_001493943.1 157826223 5644682 complement(1065617..1066084) 1 NC_009881.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; peptidoglycan-associated lipoprotein 1066084 5644682 A1C_06010 Rickettsia akari str. Hartford peptidoglycan-associated lipoprotein YP_001493943.1 1065617 R 293614 CDS YP_001493944.1 157826224 5644683 complement(1066419..1067372) 1 NC_009881.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1067372 5644683 A1C_06015 Rickettsia akari str. Hartford 3-oxoacyl-ACP synthase YP_001493944.1 1066419 R 293614 CDS YP_001493945.1 157826225 5644684 complement(1067380..1067580) 1 NC_009881.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1067580 rpmF 5644684 rpmF Rickettsia akari str. Hartford 50S ribosomal protein L32 YP_001493945.1 1067380 R 293614 CDS YP_001493946.1 157826226 5645803 1067676..1068149 1 NC_009881.1 COG2913 Small protein A (tmRNA-binding); hypothetical protein 1068149 5645803 A1C_06025 Rickettsia akari str. Hartford hypothetical protein YP_001493946.1 1067676 D 293614 CDS YP_001493947.1 157826227 5645804 1068315..1069226 1 NC_009881.1 COG0552 Signal recognition particle GTPase; Signal recognition particle-docking protein FtsY 1069226 5645804 A1C_06030 Rickettsia akari str. Hartford Signal recognition particle-docking protein FtsY YP_001493947.1 1068315 D 293614 CDS YP_001493948.1 157826228 5645805 1069423..1072041 1 NC_009881.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1072041 5645805 A1C_06035 Rickettsia akari str. Hartford DNA polymerase I YP_001493948.1 1069423 D 293614 CDS YP_001493949.1 157826229 5645806 1072655..1073797 1 NC_009881.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1073797 5645806 A1C_06040 Rickettsia akari str. Hartford S-adenosylmethionine synthetase YP_001493949.1 1072655 D 293614 CDS YP_001493950.1 157826230 5645807 1074278..1074622 1 NC_009881.1 hypothetical protein 1074622 5645807 A1C_06045 Rickettsia akari str. Hartford hypothetical protein YP_001493950.1 1074278 D 293614 CDS YP_001493951.1 157826231 5645808 complement(1075171..1078728) 1 NC_009881.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1078728 dnaE 5645808 dnaE Rickettsia akari str. Hartford DNA polymerase III subunit alpha YP_001493951.1 1075171 R 293614 CDS YP_001493952.1 157826232 5645809 complement(1078877..1080181) 1 NC_009881.1 COG1004 Predicted UDP-glucose 6-dehydrogenase; UDP-glucose 6-dehydrogenase 1080181 5645809 A1C_06055 Rickettsia akari str. Hartford UDP-glucose 6-dehydrogenase YP_001493952.1 1078877 R 293614 CDS YP_001493953.1 157826233 5645810 1080430..1082943 1 NC_009881.1 hypothetical protein 1082943 5645810 A1C_06060 Rickettsia akari str. Hartford hypothetical protein YP_001493953.1 1080430 D 293614 CDS YP_001493954.1 157826234 5644840 1082953..1084218 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; AmpG protein 1084218 5644840 A1C_06065 Rickettsia akari str. Hartford AmpG protein YP_001493954.1 1082953 D 293614 CDS YP_001493955.1 157826235 5644841 1084285..1085040 1 NC_009881.1 COG0805 Sec-independent protein secretion pathway component TatC; Sec-independent protein translocase protein TatC 1085040 5644841 A1C_06070 Rickettsia akari str. Hartford Sec-independent protein translocase protein TatC YP_001493955.1 1084285 D 293614 CDS YP_001493956.1 157826236 5644842 1085018..1086295 1 NC_009881.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1086295 5644842 A1C_06075 Rickettsia akari str. Hartford seryl-tRNA synthetase YP_001493956.1 1085018 D 293614 CDS YP_001493957.1 157826237 5644843 1086555..1088987 1 NC_009881.1 COG3451 Type IV secretory pathway, VirB4 components; Type IV secretion/conjugal transfer ATPase, VirB4 family protein 1088987 5644843 A1C_06080 Rickettsia akari str. Hartford Type IV secretion/conjugal transfer ATPase, VirB4 family protein YP_001493957.1 1086555 D 293614 CDS YP_001493958.1 157826238 5644844 1089243..1092779 1 NC_009881.1 hypothetical protein 1092779 5644844 A1C_06085 Rickettsia akari str. Hartford hypothetical protein YP_001493958.1 1089243 D 293614 CDS YP_001493959.1 157826239 5644845 1092784..1093689 1 NC_009881.1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance; tellurium resistance protein TerC 1093689 5644845 A1C_06090 Rickettsia akari str. Hartford tellurium resistance protein TerC YP_001493959.1 1092784 D 293614 CDS YP_001493960.1 157826240 5644846 1093732..1094445 1 NC_009881.1 COG3637 Opacity protein and related surface antigens; hypothetical protein 1094445 5644846 A1C_06095 Rickettsia akari str. Hartford hypothetical protein YP_001493960.1 1093732 D 293614 CDS YP_001493961.1 157826241 5644847 1094611..1096266 1 NC_009881.1 COG0500 SAM-dependent methyltransferases; hypothetical protein 1096266 5644847 A1C_06100 Rickettsia akari str. Hartford hypothetical protein YP_001493961.1 1094611 D 293614 CDS YP_001493962.1 157826242 5644619 1096432..1097049 1 NC_009881.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 1097049 5644619 A1C_06105 Rickettsia akari str. Hartford NADH dehydrogenase subunit J YP_001493962.1 1096432 D 293614 CDS YP_001493963.1 157826243 5644620 1097042..1097356 1 NC_009881.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 1097356 5644620 A1C_06110 Rickettsia akari str. Hartford NADH dehydrogenase subunit K YP_001493963.1 1097042 D 293614 CDS YP_001493964.1 157826244 5644621 1097358..1099328 1 NC_009881.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 1099328 5644621 A1C_06115 Rickettsia akari str. Hartford NADH dehydrogenase subunit L YP_001493964.1 1097358 D 293614 CDS YP_001493965.1 157826245 5644622 1099479..1100960 1 NC_009881.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 1100960 5644622 A1C_06120 Rickettsia akari str. Hartford NADH dehydrogenase subunit M YP_001493965.1 1099479 D 293614 CDS YP_001493966.1 157826246 5644623 1100961..1101065 1 NC_009881.1 hypothetical protein 1101065 5644623 A1C_06125 Rickettsia akari str. Hartford hypothetical protein YP_001493966.1 1100961 D 293614 CDS YP_001493967.1 157826247 5644624 1101314..1101934 1 NC_009881.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 1101934 5644624 A1C_06130 Rickettsia akari str. Hartford cytochrome c biogenesis protein CcmA YP_001493967.1 1101314 D 293614 CDS YP_001493968.1 157826248 5644625 complement(1102527..1103006) 1 NC_009881.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 1103006 5644625 A1C_06135 Rickettsia akari str. Hartford NADH dehydrogenase subunit I YP_001493968.1 1102527 R 293614 CDS YP_001493969.1 157826249 5644626 1103224..1103394 1 NC_009881.1 COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I); NADH dehydrogenase subunit H 1103394 5644626 A1C_06140 Rickettsia akari str. Hartford NADH dehydrogenase subunit H YP_001493969.1 1103224 D 293614 CDS YP_001493970.1 157826250 5644720 complement(1103533..1104552) 1 NC_009881.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 1104552 5644720 A1C_06145 Rickettsia akari str. Hartford NADH dehydrogenase subunit H YP_001493970.1 1103533 R 293614 CDS YP_001493971.1 157826251 5644721 complement(1104700..1106715) 1 NC_009881.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 1106715 5644721 A1C_06150 Rickettsia akari str. Hartford NADH dehydrogenase subunit G YP_001493971.1 1104700 R 293614 CDS YP_001493972.1 157826252 5644722 complement(1106717..1107073) 1 NC_009881.1 COG3671 Predicted membrane protein; hypothetical protein 1107073 5644722 A1C_06155 Rickettsia akari str. Hartford hypothetical protein YP_001493972.1 1106717 R 293614 CDS YP_001493973.1 157826253 5644723 complement(1107088..1107324) 1 NC_009881.1 hypothetical protein 1107324 5644723 A1C_06160 Rickettsia akari str. Hartford hypothetical protein YP_001493973.1 1107088 R 293614 CDS YP_001493974.1 157826254 5644724 complement(1107396..1107557) 1 NC_009881.1 hypothetical protein 1107557 5644724 A1C_06165 Rickettsia akari str. Hartford hypothetical protein YP_001493974.1 1107396 R 293614 CDS YP_001493975.1 157826255 5644725 complement(1107958..1110594) 1 NC_009881.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1110594 5644725 A1C_06180 Rickettsia akari str. Hartford aconitate hydratase YP_001493975.1 1107958 R 293614 CDS YP_001493976.1 157826256 5644726 complement(1110790..1111128) 1 NC_009881.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 1111128 atpC 5644726 atpC Rickettsia akari str. Hartford F0F1 ATP synthase subunit epsilon YP_001493976.1 1110790 R 293614 CDS YP_001493977.1 157826257 5644727 complement(1111317..1112738) 1 NC_009881.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1112738 5644727 A1C_06190 Rickettsia akari str. Hartford F0F1 ATP synthase subunit beta YP_001493977.1 1111317 R 293614 CDS YP_001493978.1 157826258 5645767 complement(1112821..1113687) 1 NC_009881.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1113687 5645767 A1C_06195 Rickettsia akari str. Hartford F0F1 ATP synthase subunit gamma YP_001493978.1 1112821 R 293614 CDS YP_001493979.1 157826259 5645768 complement(1113777..1115315) 1 NC_009881.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1115315 5645768 A1C_06200 Rickettsia akari str. Hartford F0F1 ATP synthase subunit alpha YP_001493979.1 1113777 R 293614 CDS YP_001493980.1 157826260 5645769 complement(1115446..1116000) 1 NC_009881.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1116000 5645769 A1C_06205 Rickettsia akari str. Hartford F0F1 ATP synthase subunit delta YP_001493980.1 1115446 R 293614 CDS YP_001493981.1 157826261 5645770 complement(1115997..1117376) 1 NC_009881.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 1117376 5645770 A1C_06210 Rickettsia akari str. Hartford dihydrolipoamide dehydrogenase YP_001493981.1 1115997 R 293614 CDS YP_001493982.1 157826262 5645771 complement(1117480..1117908) 1 NC_009881.1 COG0783 DNA-binding ferritin-like protein (oxidative damage protectant); Strees induced DNA-binding protein 1117908 5645771 A1C_06215 Rickettsia akari str. Hartford Strees induced DNA-binding protein YP_001493982.1 1117480 R 293614 CDS YP_001493983.1 157826263 5645772 complement(1118207..1118395) 1 NC_009881.1 hypothetical protein 1118395 5645772 A1C_06220 Rickettsia akari str. Hartford hypothetical protein YP_001493983.1 1118207 R 293614 CDS YP_001493984.1 157826264 5645773 1118604..1119695 1 NC_009881.1 hypothetical protein 1119695 5645773 A1C_06225 Rickettsia akari str. Hartford hypothetical protein YP_001493984.1 1118604 D 293614 CDS YP_001493985.1 157826265 5645774 complement(1120674..1123049) 1 NC_009881.1 COG5009 Membrane carboxypeptidase/penicillin-binding protein; 1A family penicillin-binding protein 1123049 5645774 A1C_06240 Rickettsia akari str. Hartford 1A family penicillin-binding protein YP_001493985.1 1120674 R 293614 CDS YP_001493986.1 157826266 5645544 complement(1123053..1124390) 1 NC_009881.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 1124390 5645544 A1C_06245 Rickettsia akari str. Hartford (dimethylallyl)adenosine tRNA methylthiotransferase YP_001493986.1 1123053 R 293614 CDS YP_001493987.1 157826267 5645545 complement(1124495..1124644) 1 NC_009881.1 hypothetical protein 1124644 5645545 A1C_06250 Rickettsia akari str. Hartford hypothetical protein YP_001493987.1 1124495 R 293614 CDS YP_001493988.1 157826268 5645546 complement(1124933..1125109) 1 NC_009881.1 hypothetical protein 1125109 5645546 A1C_06255 Rickettsia akari str. Hartford hypothetical protein YP_001493988.1 1124933 R 293614 CDS YP_001493989.1 157826269 5645547 complement(1126182..1126661) 1 NC_009881.1 COG3807 Uncharacterized protein conserved in bacteria; hypothetical protein 1126661 5645547 A1C_06270 Rickettsia akari str. Hartford hypothetical protein YP_001493989.1 1126182 R 293614 CDS YP_001493990.1 157826270 5645548 complement(1126654..1128381) 1 NC_009881.1 COG0475 Kef-type K+ transport systems, membrane components; glutathione-regulated potassium-efflux system protein kefB 1128381 5645548 A1C_06275 Rickettsia akari str. Hartford glutathione-regulated potassium-efflux system protein kefB YP_001493990.1 1126654 R 293614 CDS YP_001493991.1 157826271 5645549 complement(1128378..1128704) 1 NC_009881.1 COG0799 Uncharacterized homolog of plant Iojap protein; Iojap-related protein 1128704 5645549 A1C_06280 Rickettsia akari str. Hartford Iojap-related protein YP_001493991.1 1128378 R 293614 CDS YP_001493992.1 157826272 5645550 1128870..1129109 1 NC_009881.1 COG0271 Stress-induced morphogen (activity unknown); hypothetical protein 1129109 5645550 A1C_06285 Rickettsia akari str. Hartford hypothetical protein YP_001493992.1 1128870 D 293614 CDS YP_001493993.1 157826273 5645551 1129295..1129435 1 NC_009881.1 hypothetical protein 1129435 5645551 A1C_06290 Rickettsia akari str. Hartford hypothetical protein YP_001493993.1 1129295 D 293614 CDS YP_001493994.1 157826274 5644685 1129551..1129874 1 NC_009881.1 COG1396 Predicted transcriptional regulators; Phage-related transcriptional regulator 1129874 5644685 A1C_06295 Rickettsia akari str. Hartford Phage-related transcriptional regulator YP_001493994.1 1129551 D 293614 CDS YP_001493995.1 157826275 5644687 1130725..1130940 1 NC_009881.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1130940 infA 5644687 infA Rickettsia akari str. Hartford translation initiation factor IF-1 YP_001493995.1 1130725 D 293614 CDS YP_001493996.1 157826276 5644688 1130952..1131557 1 NC_009881.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1131557 5644688 A1C_06305 Rickettsia akari str. Hartford Maf-like protein YP_001493996.1 1130952 D 293614 CDS YP_001493997.1 157826277 5644689 complement(1131856..1132287) 1 NC_009881.1 COG1734 DnaK suppressor protein; DnaK suppressor protein 1132287 5644689 A1C_06310 Rickettsia akari str. Hartford DnaK suppressor protein YP_001493997.1 1131856 R 293614 CDS YP_001493998.1 157826278 5644690 complement(1132386..1133303) 1 NC_009881.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 1133303 xerC 5644690 xerC Rickettsia akari str. Hartford site-specific tyrosine recombinase XerC YP_001493998.1 1132386 R 293614 CDS YP_001493999.1 157826279 5644691 1133472..1133951 1 NC_009881.1 phasin family protein 1133951 5644691 A1C_06320 Rickettsia akari str. Hartford phasin family protein YP_001493999.1 1133472 D 293614 CDS YP_001494000.1 157826280 5644948 complement(1134110..1134712) 1 NC_009881.1 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; phospholipase D 1134712 5644948 A1C_06325 Rickettsia akari str. Hartford phospholipase D YP_001494000.1 1134110 R 293614 CDS YP_001494001.1 157826281 5644949 complement(1134805..1136556) 1 NC_009881.1 COG3243 Poly(3-hydroxyalkanoate) synthetase; Poly(3-hydroxyalkanoate) synthetase 1136556 5644949 A1C_06330 Rickettsia akari str. Hartford Poly(3-hydroxyalkanoate) synthetase YP_001494001.1 1134805 R 293614 CDS YP_001494002.1 157826282 5644950 complement(1136638..1138116) 1 NC_009881.1 COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases; UbiD family decarboxylase 1138116 5644950 A1C_06335 Rickettsia akari str. Hartford UbiD family decarboxylase YP_001494002.1 1136638 R 293614 CDS YP_001494003.1 157826283 5644951 complement(1138322..1139896) 1 NC_009881.1 COG0760 Parvulin-like peptidyl-prolyl isomerase; parvulin-like peptidyl-prolyl isomerase 1139896 5644951 A1C_06340 Rickettsia akari str. Hartford parvulin-like peptidyl-prolyl isomerase YP_001494003.1 1138322 R 293614 CDS YP_001494004.1 157826284 5644952 complement(1141002..1141208) 1 NC_009881.1 hypothetical protein 1141208 5644952 A1C_06355 Rickettsia akari str. Hartford hypothetical protein YP_001494004.1 1141002 R 293614 CDS YP_001494005.1 157826285 5644953 complement(1141269..1141397) 1 NC_009881.1 hypothetical protein 1141397 5644953 A1C_06360 Rickettsia akari str. Hartford hypothetical protein YP_001494005.1 1141269 R 293614 CDS YP_001494006.1 157826286 5644954 complement(1141500..1142210) 1 NC_009881.1 hypothetical protein 1142210 5644954 A1C_06365 Rickettsia akari str. Hartford hypothetical protein YP_001494006.1 1141500 R 293614 CDS YP_001494007.1 157826287 5644955 complement(1142468..1143022) 1 NC_009881.1 outer membrane protein OmpA 1143022 5644955 A1C_06370 Rickettsia akari str. Hartford outer membrane protein OmpA YP_001494007.1 1142468 R 293614 CDS YP_001494008.1 157826288 5645395 complement(1142989..1143387) 1 NC_009881.1 outer membrane protein OmpA 1143387 5645395 A1C_06375 Rickettsia akari str. Hartford outer membrane protein OmpA YP_001494008.1 1142989 R 293614 CDS YP_001494009.1 157826289 5645396 complement(1143539..1143637) 1 NC_009881.1 hypothetical protein 1143637 5645396 A1C_06380 Rickettsia akari str. Hartford hypothetical protein YP_001494009.1 1143539 R 293614 CDS YP_001494010.1 157826290 5645397 complement(1143803..1144294) 1 NC_009881.1 hypothetical protein 1144294 5645397 A1C_06385 Rickettsia akari str. Hartford hypothetical protein YP_001494010.1 1143803 R 293614 CDS YP_001494011.1 157826291 5645398 complement(1144603..1146840) 1 NC_009881.1 COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins; cell division protein FtsK 1146840 5645398 A1C_06390 Rickettsia akari str. Hartford cell division protein FtsK YP_001494011.1 1144603 R 293614 CDS YP_001494012.1 157826292 5645399 1146993..1147784 1 NC_009881.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 1147784 5645399 A1C_06395 Rickettsia akari str. Hartford methionine aminopeptidase YP_001494012.1 1146993 D 293614 CDS YP_001494013.1 157826293 5645400 1148887..1149870 1 NC_009881.1 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase 1149870 5645400 A1C_06410 Rickettsia akari str. Hartford undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase YP_001494013.1 1148887 D 293614 CDS YP_001494014.1 157826294 5645401 1149867..1150193 1 NC_009881.1 hypothetical protein 1150193 5645401 A1C_06415 Rickettsia akari str. Hartford hypothetical protein YP_001494014.1 1149867 D 293614 CDS YP_001494015.1 157826295 5645402 complement(1150629..1151462) 1 NC_009881.1 COG3637 Opacity protein and related surface antigens; hypothetical protein 1151462 5645402 A1C_06420 Rickettsia akari str. Hartford hypothetical protein YP_001494015.1 1150629 R 293614 CDS YP_001494016.1 157826296 5645179 complement(1151697..1152371) 1 NC_009881.1 COG3637 Opacity protein and related surface antigens; putative outer surface protein 1152371 5645179 A1C_06425 Rickettsia akari str. Hartford putative outer surface protein YP_001494016.1 1151697 R 293614 CDS YP_001494017.1 157826297 5645180 complement(1152520..1152849) 1 NC_009881.1 COG1146 Ferredoxin; ferredoxin 1152849 5645180 A1C_06430 Rickettsia akari str. Hartford ferredoxin YP_001494017.1 1152520 R 293614 CDS YP_001494018.1 157826298 5645181 complement(1152854..1153546) 1 NC_009881.1 COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component; Heme exporter protein C 1153546 5645181 A1C_06435 Rickettsia akari str. Hartford Heme exporter protein C YP_001494018.1 1152854 R 293614 CDS YP_001494019.1 157826299 5645182 complement(1153755..1154234) 1 NC_009881.1 COG0590 Cytosine/adenosine deaminases; cytosine deaminase 1154234 5645182 A1C_06440 Rickettsia akari str. Hartford cytosine deaminase YP_001494019.1 1153755 R 293614 CDS YP_001494020.1 157826300 5645183 complement(1154215..1155120) 1 NC_009881.1 COG0053 Predicted Co/Zn/Cd cation transporters; cation diffusion facilitator family transporter 1155120 5645183 A1C_06445 Rickettsia akari str. Hartford cation diffusion facilitator family transporter YP_001494020.1 1154215 R 293614 CDS YP_001494021.1 157826301 5645184 1155248..1155727 1 NC_009881.1 COG4520 Surface antigen; 17 kD surface antigen 1155727 5645184 A1C_06450 Rickettsia akari str. Hartford 17 kD surface antigen YP_001494021.1 1155248 D 293614 CDS YP_001494022.1 157826302 5645185 1155882..1156094 1 NC_009881.1 COG1881 Phospholipid-binding protein; hypothetical protein 1156094 5645185 A1C_06455 Rickettsia akari str. Hartford hypothetical protein YP_001494022.1 1155882 D 293614 CDS YP_001494023.1 157826303 5645186 1156530..1157231 1 NC_009881.1 COG1121 ABC-type Mn/Zn transport systems, ATPase component; Zinc ABC transporter ATP-binding protein 1157231 5645186 A1C_06460 Rickettsia akari str. Hartford Zinc ABC transporter ATP-binding protein YP_001494023.1 1156530 D 293614 CDS YP_001494024.1 157826304 5644897 complement(1157234..1160095) 1 NC_009881.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1160095 uvrA 5644897 uvrA Rickettsia akari str. Hartford excinuclease ABC subunit A YP_001494024.1 1157234 R 293614 CDS YP_001494025.1 157826305 5644898 1160204..1160662 1 NC_009881.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1160662 5644898 A1C_06470 Rickettsia akari str. Hartford single-stranded DNA-binding protein YP_001494025.1 1160204 D 293614 CDS YP_001494026.1 157826306 5644899 1160868..1161695 1 NC_009881.1 DAP2-like protein 1161695 5644899 A1C_06475 Rickettsia akari str. Hartford DAP2-like protein YP_001494026.1 1160868 D 293614 CDS YP_001494027.1 157826307 5644900 1161937..1162494 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; MFS type sugar transporter 1162494 5644900 A1C_06480 Rickettsia akari str. Hartford MFS type sugar transporter YP_001494027.1 1161937 D 293614 CDS YP_001494028.1 157826308 5644901 1162724..1162894 1 NC_009881.1 MFS type sugar transporter 1162894 5644901 A1C_06485 Rickettsia akari str. Hartford MFS type sugar transporter YP_001494028.1 1162724 D 293614 CDS YP_001494029.1 157826309 5644902 complement(1163039..1163143) 1 NC_009881.1 hypothetical protein 1163143 5644902 A1C_06490 Rickettsia akari str. Hartford hypothetical protein YP_001494029.1 1163039 R 293614 CDS YP_001494030.1 157826310 5644903 complement(1163344..1163460) 1 NC_009881.1 hypothetical protein 1163460 5644903 A1C_06495 Rickettsia akari str. Hartford hypothetical protein YP_001494030.1 1163344 R 293614 CDS YP_001494031.1 157826311 5644904 complement(1163990..1164184) 1 NC_009881.1 hypothetical protein 1164184 5644904 A1C_06500 Rickettsia akari str. Hartford hypothetical protein YP_001494031.1 1163990 R 293614 CDS YP_001494032.1 157826312 5645299 complement(1164228..1164338) 1 NC_009881.1 hypothetical protein 1164338 5645299 A1C_06505 Rickettsia akari str. Hartford hypothetical protein YP_001494032.1 1164228 R 293614 CDS YP_001494033.1 157826313 5645301 1165200..1165517 1 NC_009881.1 COG1872 Uncharacterized conserved protein; hypothetical protein 1165517 5645301 A1C_06510 Rickettsia akari str. Hartford hypothetical protein YP_001494033.1 1165200 D 293614 CDS YP_001494034.1 157826314 5645302 1165686..1167551 1 NC_009881.1 molecular chaperone; heat shock protein 90 1167551 5645302 A1C_06515 Rickettsia akari str. Hartford heat shock protein 90 YP_001494034.1 1165686 D 293614 CDS YP_001494035.1 157826315 5645303 1167736..1168980 1 NC_009881.1 catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine; 5-aminolevulinate synthase 1168980 5645303 A1C_06520 Rickettsia akari str. Hartford 5-aminolevulinate synthase YP_001494035.1 1167736 D 293614 CDS YP_001494036.1 157826316 5645304 1169241..1169696 1 NC_009881.1 hypothetical protein 1169696 5645304 A1C_06525 Rickettsia akari str. Hartford hypothetical protein YP_001494036.1 1169241 D 293614 CDS YP_001494037.1 157826317 5645305 1170181..1171518 1 NC_009881.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1171518 tig 5645305 tig Rickettsia akari str. Hartford trigger factor YP_001494037.1 1170181 D 293614 CDS YP_001494038.1 157826318 5645860 complement(1171732..1172724) 1 NC_009881.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1172724 obgE 5645860 obgE Rickettsia akari str. Hartford GTPase ObgE YP_001494038.1 1171732 R 293614 CDS YP_001494039.1 157826319 5645861 complement(1172942..1174249) 1 NC_009881.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 1174249 gltA 5645861 gltA Rickettsia akari str. Hartford type II citrate synthase YP_001494039.1 1172942 R 293614 CDS YP_001494040.1 157826320 5645862 complement(1174616..1174792) 1 NC_009881.1 transcriptional regulator 1174792 5645862 A1C_06545 Rickettsia akari str. Hartford transcriptional regulator YP_001494040.1 1174616 R 293614 CDS YP_001494041.1 157826321 5645863 complement(1174989..1175978) 1 NC_009881.1 COG1573 Uracil-DNA glycosylase; hypothetical protein 1175978 5645863 A1C_06550 Rickettsia akari str. Hartford hypothetical protein YP_001494041.1 1174989 R 293614 CDS YP_001494042.1 157826322 5645864 1175941..1176930 1 NC_009881.1 COG0564 Pseudouridylate synthases, 23S RNA-specific; ribosomal large subunit pseudouridine synthase, RluD subfamily protein 1176930 5645864 A1C_06555 Rickettsia akari str. Hartford ribosomal large subunit pseudouridine synthase, RluD subfamily protein YP_001494042.1 1175941 D 293614 CDS YP_001494043.1 157826323 5645865 1177943..1178068 1 NC_009881.1 hypothetical protein 1178068 5645865 A1C_06560 Rickettsia akari str. Hartford hypothetical protein YP_001494043.1 1177943 D 293614 CDS YP_001494044.1 157826324 5645866 1178163..1178429 1 NC_009881.1 COG2337 Growth inhibitor; growth inhibitor 1178429 5645866 A1C_06565 Rickettsia akari str. Hartford growth inhibitor YP_001494044.1 1178163 D 293614 CDS YP_001494045.1 157826325 5645867 1178414..1179982 1 NC_009881.1 fusion of hemK/trmB; N-terminal HemK domain transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; C-terminal; bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase 1179982 5645867 A1C_06570 Rickettsia akari str. Hartford bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase YP_001494045.1 1178414 D 293614 CDS YP_001494046.1 157826326 5645291 complement(1179948..1180886) 1 NC_009881.1 COG0009 Putative translation factor (SUA5); hypothetical protein 1180886 5645291 A1C_06575 Rickettsia akari str. Hartford hypothetical protein YP_001494046.1 1179948 R 293614 CDS YP_001494047.1 157826327 5645292 complement(1180965..1182953) 1 NC_009881.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1182953 glyS 5645292 glyS Rickettsia akari str. Hartford glycyl-tRNA synthetase subunit beta YP_001494047.1 1180965 R 293614 CDS YP_001494048.1 157826328 5645293 complement(1182946..1183815) 1 NC_009881.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1183815 glyQ 5645293 glyQ Rickettsia akari str. Hartford glycyl-tRNA synthetase subunit alpha YP_001494048.1 1182946 R 293614 CDS YP_001494049.1 157826329 5645294 complement(1183847..1183981) 1 NC_009881.1 COG1487 Predicted nucleic acid-binding protein, contains PIN domain; hypothetical protein 1183981 5645294 A1C_06590 Rickettsia akari str. Hartford hypothetical protein YP_001494049.1 1183847 R 293614 CDS YP_001494050.1 157826330 5645295 complement(1184267..1184896) 1 NC_009881.1 COG1636 Uncharacterized protein conserved in bacteria; hypothetical protein 1184896 5645295 A1C_06595 Rickettsia akari str. Hartford hypothetical protein YP_001494050.1 1184267 R 293614 CDS YP_001494051.1 157826331 5645296 complement(1184905..1185396) 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; proline/betaine transporter 1185396 5645296 A1C_06600 Rickettsia akari str. Hartford proline/betaine transporter YP_001494051.1 1184905 R 293614 CDS YP_001494052.1 157826332 5645297 complement(1185345..1186151) 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; proline/betaine transporter 1186151 5645297 A1C_06605 Rickettsia akari str. Hartford proline/betaine transporter YP_001494052.1 1185345 R 293614 CDS YP_001494053.1 157826333 5645298 complement(1186519..1187472) 1 NC_009881.1 hypothetical protein 1187472 5645298 A1C_06610 Rickettsia akari str. Hartford hypothetical protein YP_001494053.1 1186519 R 293614 CDS YP_001494054.1 157826334 5645593 complement(1187482..1188120) 1 NC_009881.1 COG1474 Cdc6-related protein, AAA superfamily ATPase; hypothetical protein 1188120 5645593 A1C_06615 Rickettsia akari str. Hartford hypothetical protein YP_001494054.1 1187482 R 293614 CDS YP_001494055.1 157826335 5645594 complement(1188374..1189945) 1 NC_009881.1 hypothetical protein 1189945 5645594 A1C_06620 Rickettsia akari str. Hartford hypothetical protein YP_001494055.1 1188374 R 293614 CDS YP_001494056.1 157826336 5645595 1190166..1192802 1 NC_009881.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1192802 alaS 5645595 alaS Rickettsia akari str. Hartford alanyl-tRNA synthetase YP_001494056.1 1190166 D 293614 CDS YP_001494057.1 157826337 5645596 complement(1193016..1193342) 1 NC_009881.1 hypothetical protein 1193342 5645596 A1C_06630 Rickettsia akari str. Hartford hypothetical protein YP_001494057.1 1193016 R 293614 CDS YP_001494058.1 157826338 5645597 complement(1193544..1193768) 1 NC_009881.1 hypothetical protein 1193768 5645597 A1C_06635 Rickettsia akari str. Hartford hypothetical protein YP_001494058.1 1193544 R 293614 CDS YP_001494059.1 157826339 5645598 complement(1194006..1194278) 1 NC_009881.1 tRNA pseudouridine synthase A 1194278 truA 5645598 truA Rickettsia akari str. Hartford tRNA pseudouridine synthase A YP_001494059.1 1194006 R 293614 CDS YP_001494060.1 157826340 5645599 complement(1194244..1194474) 1 NC_009881.1 hypothetical protein 1194474 5645599 A1C_06645 Rickettsia akari str. Hartford hypothetical protein YP_001494060.1 1194244 R 293614 CDS YP_001494061.1 157826341 5645600 complement(1194517..1194672) 1 NC_009881.1 hypothetical protein 1194672 5645600 A1C_06650 Rickettsia akari str. Hartford hypothetical protein YP_001494061.1 1194517 R 293614 CDS YP_001494062.1 157826342 5645679 complement(1194849..1195133) 1 NC_009881.1 hypothetical protein 1195133 5645679 A1C_06655 Rickettsia akari str. Hartford hypothetical protein YP_001494062.1 1194849 R 293614 CDS YP_001494063.1 157826343 5645680 complement(1195282..1196019) 1 NC_009881.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1196019 truA 5645680 truA Rickettsia akari str. Hartford tRNA pseudouridine synthase A YP_001494063.1 1195282 R 293614 CDS YP_001494064.1 157826344 5645681 complement(1196228..1198135) 1 NC_009881.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 1198135 5645681 A1C_06665 Rickettsia akari str. Hartford RNA polymerase sigma factor RpoD YP_001494064.1 1196228 R 293614 CDS YP_001494065.1 157826345 5645682 complement(1198179..1199966) 1 NC_009881.1 synthesizes RNA primers at the replication forks; DNA primase 1199966 dnaG 5645682 dnaG Rickettsia akari str. Hartford DNA primase YP_001494065.1 1198179 R 293614 CDS YP_001494066.1 157826346 5645683 complement(1199971..1200585) 1 NC_009881.1 COG0170 Dolichol kinase; dolichol kinase 1200585 5645683 A1C_06675 Rickettsia akari str. Hartford dolichol kinase YP_001494066.1 1199971 R 293614 CDS YP_001494067.1 157826347 5645684 1200875..1201453 1 NC_009881.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1201453 greA 5645684 greA Rickettsia akari str. Hartford transcription elongation factor GreA YP_001494067.1 1200875 D 293614 CDS YP_001494068.1 157826348 5645685 complement(1201620..1202018) 1 NC_009881.1 COG3288 NAD/NADP transhydrogenase alpha subunit; NAD(P) transhydrogenase subunit alpha 1202018 5645685 A1C_06685 Rickettsia akari str. Hartford NAD(P) transhydrogenase subunit alpha YP_001494068.1 1201620 R 293614 CDS YP_001494069.1 157826349 5645686 complement(1202095..1203216) 1 NC_009881.1 COG3288 NAD/NADP transhydrogenase alpha subunit; NAD(P) transhydrogenase subunit alpha 1203216 5645686 A1C_06690 Rickettsia akari str. Hartford NAD(P) transhydrogenase subunit alpha YP_001494069.1 1202095 R 293614 CDS YP_001494070.1 157826350 5644912 1203285..1203923 1 NC_009881.1 COG2834 Outer membrane lipoprotein-sorting protein; hypothetical protein 1203923 5644912 A1C_06695 Rickettsia akari str. Hartford hypothetical protein YP_001494070.1 1203285 D 293614 CDS YP_001494071.1 157826351 5644913 1204294..1205823 1 NC_009881.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; rhe tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 1205823 5644913 A1C_06700 Rickettsia akari str. Hartford DNA polymerase III subunits gamma and tau YP_001494071.1 1204294 D 293614 CDS YP_001494072.1 157826352 5644914 1205835..1206158 1 NC_009881.1 COG0718 Uncharacterized protein conserved in bacteria; hypothetical protein 1206158 5644914 A1C_06705 Rickettsia akari str. Hartford hypothetical protein YP_001494072.1 1205835 D 293614 CDS YP_001494073.1 157826353 5644915 complement(1206413..1207108) 1 NC_009881.1 COG3577 Predicted aspartyl protease; hypothetical protein 1207108 5644915 A1C_06710 Rickettsia akari str. Hartford hypothetical protein YP_001494073.1 1206413 R 293614 CDS YP_001494074.1 157826354 5644916 complement(1207342..1207644) 1 NC_009881.1 COG1680 Beta-lactamase class C and other penicillin binding proteins; beta-lactamase AmpC 1207644 5644916 A1C_06715 Rickettsia akari str. Hartford beta-lactamase AmpC YP_001494074.1 1207342 R 293614 CDS YP_001494075.1 157826355 5644917 complement(1208235..1208957) 1 NC_009881.1 COG1126 ABC-type polar amino acid transport system, ATPase component; glutamine ABC transporter ATP-binding protein 1208957 5644917 A1C_06720 Rickettsia akari str. Hartford glutamine ABC transporter ATP-binding protein YP_001494075.1 1208235 R 293614 CDS YP_001494076.1 157826356 5644918 complement(1208961..1209725) 1 NC_009881.1 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I; beta-lactamase superfamily hydrolase 1209725 5644918 A1C_06725 Rickettsia akari str. Hartford beta-lactamase superfamily hydrolase YP_001494076.1 1208961 R 293614 CDS YP_001494077.1 157826357 5644919 1209737..1210411 1 NC_009881.1 COG0671 Membrane-associated phospholipid phosphatase; hypothetical protein 1210411 5644919 A1C_06730 Rickettsia akari str. Hartford hypothetical protein YP_001494077.1 1209737 D 293614 CDS YP_001494078.1 157826358 5644589 1210485..1211567 1 NC_009881.1 COG0795 Predicted permeases; hypothetical protein 1211567 5644589 A1C_06735 Rickettsia akari str. Hartford hypothetical protein YP_001494078.1 1210485 D 293614 CDS YP_001494079.1 157826359 5644590 complement(1211570..1212034) 1 NC_009881.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 1212034 5644590 A1C_06740 Rickettsia akari str. Hartford DNA polymerase III subunit chi YP_001494079.1 1211570 R 293614 CDS YP_001494080.1 157826360 5644591 1212370..1212645 1 NC_009881.1 succinyl-diaminopimelate desuccinylase 1212645 5644591 A1C_06745 Rickettsia akari str. Hartford succinyl-diaminopimelate desuccinylase YP_001494080.1 1212370 D 293614 CDS YP_001494081.1 157826361 5644592 complement(1212663..1213784) 1 NC_009881.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 1213784 5644592 A1C_06750 Rickettsia akari str. Hartford succinyl-diaminopimelate desuccinylase YP_001494081.1 1212663 R 293614 CDS YP_001494082.1 157826362 5644593 complement(1213812..1214204) 1 NC_009881.1 COG0286 Type I restriction-modification system methyltransferase subunit; Type I restriction-modification system methyltransferase subunit 1214204 5644593 A1C_06755 Rickettsia akari str. Hartford Type I restriction-modification system methyltransferase subunit YP_001494082.1 1213812 R 293614 CDS YP_001494083.1 157826363 5644594 complement(1214328..1214627) 1 NC_009881.1 Type I restriction-modification system methyltransferase subunit 1214627 5644594 A1C_06760 Rickettsia akari str. Hartford Type I restriction-modification system methyltransferase subunit YP_001494083.1 1214328 R 293614 CDS YP_001494084.1 157826364 5644595 complement(1214745..1214966) 1 NC_009881.1 Type I restriction-modification system methyltransferase subunit 1214966 5644595 A1C_06765 Rickettsia akari str. Hartford Type I restriction-modification system methyltransferase subunit YP_001494084.1 1214745 R 293614 CDS YP_001494085.1 157826365 5644596 1215462..1215668 1 NC_009881.1 COG3004 Na+/H+ antiporter; Na+/H+ antiporter NhaA 1215668 5644596 A1C_06770 Rickettsia akari str. Hartford Na+/H+ antiporter NhaA YP_001494085.1 1215462 D 293614 CDS YP_001494086.1 157826366 5645552 1216078..1216323 1 NC_009881.1 COG3004 Na+/H+ antiporter; Na+/H+ antiporter NhaA 1216323 5645552 A1C_06775 Rickettsia akari str. Hartford Na+/H+ antiporter NhaA YP_001494086.1 1216078 D 293614 CDS YP_001494087.1 157826367 5645553 complement(1216580..1217104) 1 NC_009881.1 COG1434 Uncharacterized conserved protein; hypothetical protein 1217104 5645553 A1C_06780 Rickettsia akari str. Hartford hypothetical protein YP_001494087.1 1216580 R 293614 CDS YP_001494088.1 157826368 5645554 complement(1217101..1217730) 1 NC_009881.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1217730 lipB 5645554 lipB Rickettsia akari str. Hartford lipoate-protein ligase B YP_001494088.1 1217101 R 293614 CDS YP_001494089.1 157826369 5645555 complement(1217748..1218494) 1 NC_009881.1 COG3023 Negative regulator of beta-lactamase expression; hypothetical protein 1218494 5645555 A1C_06790 Rickettsia akari str. Hartford hypothetical protein YP_001494089.1 1217748 R 293614 CDS YP_001494090.1 157826370 5645557 complement(1218983..1219318) 1 NC_009881.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 1219318 rpsP 5645557 rpsP Rickettsia akari str. Hartford 30S ribosomal protein S16 YP_001494090.1 1218983 R 293614 CDS YP_001494091.1 157826371 5645558 complement(1219332..1219502) 1 NC_009881.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1219502 rpmG 5645558 rpmG Rickettsia akari str. Hartford 50S ribosomal protein L33 YP_001494091.1 1219332 R 293614 CDS YP_001494092.1 157826372 5645208 complement(1219680..1221509) 1 NC_009881.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 1221509 mutL 5645208 mutL Rickettsia akari str. Hartford DNA mismatch repair protein YP_001494092.1 1219680 R 293614 CDS YP_001494093.1 157826373 5645209 complement(1221506..1221658) 1 NC_009881.1 COG4391 Uncharacterized protein conserved in bacteria; hypothetical protein 1221658 5645209 A1C_06810 Rickettsia akari str. Hartford hypothetical protein YP_001494093.1 1221506 R 293614 CDS YP_001494094.1 157826374 5645210 complement(1221735..1221863) 1 NC_009881.1 hypothetical protein 1221863 5645210 A1C_06815 Rickettsia akari str. Hartford hypothetical protein YP_001494094.1 1221735 R 293614 CDS YP_001494095.1 157826375 5645211 1222470..1222736 1 NC_009881.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); oxidoreductase 1222736 5645211 A1C_06835 Rickettsia akari str. Hartford oxidoreductase YP_001494095.1 1222470 D 293614 CDS YP_001494096.1 157826376 5645212 1222856..1222975 1 NC_009881.1 hypothetical protein 1222975 5645212 A1C_06840 Rickettsia akari str. Hartford hypothetical protein YP_001494096.1 1222856 D 293614 CDS YP_001494097.1 157826377 5645213 1223031..1223237 1 NC_009881.1 hypothetical protein 1223237 5645213 A1C_06845 Rickettsia akari str. Hartford hypothetical protein YP_001494097.1 1223031 D 293614 CDS YP_001494098.1 157826378 5645214 1223234..1223332 1 NC_009881.1 hypothetical protein 1223332 5645214 A1C_06850 Rickettsia akari str. Hartford hypothetical protein YP_001494098.1 1223234 D 293614 CDS YP_001494099.1 157826379 5645215 1224633..1225904 1 NC_009881.1 COG0477 Permeases of the major facilitator superfamily; proline/betaine transporter 1225904 5645215 A1C_06855 Rickettsia akari str. Hartford proline/betaine transporter YP_001494099.1 1224633 D 293614 CDS YP_001494100.1 157826380 5645040 1225888..1226727 1 NC_009881.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 1226727 5645040 A1C_06860 Rickettsia akari str. Hartford coproporphyrinogen III oxidase YP_001494100.1 1225888 D 293614 CDS YP_001494101.1 157826381 5645041 complement(1227044..1227163) 1 NC_009881.1 hypothetical protein 1227163 5645041 A1C_06865 Rickettsia akari str. Hartford hypothetical protein YP_001494101.1 1227044 R 293614 CDS YP_001494102.1 157826382 5645042 complement(1228182..1228619) 1 NC_009881.1 COG1981 Predicted membrane protein; hypothetical protein 1228619 5645042 A1C_06870 Rickettsia akari str. Hartford hypothetical protein YP_001494102.1 1228182 R 293614 CDS YP_001494103.1 157826383 5645043 complement(1228631..1229665) 1 NC_009881.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 1229665 hemH 5645043 hemH Rickettsia akari str. Hartford ferrochelatase YP_001494103.1 1228631 R 293614 CDS YP_001494104.1 157826384 5645044 complement(1229658..1230674) 1 NC_009881.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 1230674 hemE 5645044 hemE Rickettsia akari str. Hartford uroporphyrinogen decarboxylase YP_001494104.1 1229658 R 293614 CDS