-- dump date 20140620_033318 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 347255000001 SEQ_END SEQ_END NC_012633.1 1278540 1278540 DR NC_012633.1; contig end 1278540..1278540 Rickettsia africae ESF-5 347255000002 SEQ_END SEQ_END NC_012634.1 12377 12377 DR NC_012634.1; contig end 12377..12377 Rickettsia africae ESF-5 YP_002844732.1 CDS RAF_ORF0001 NC_012633.1 1 822 D hypothetical protein 1..822 Rickettsia africae ESF-5 7815849 YP_002844733.1 CDS trxA NC_012633.1 1040 1357 D Thioredoxin 1040..1357 Rickettsia africae ESF-5 7815851 YP_002844734.1 CDS rfbE NC_012633.1 1368 2117 D O-antigen export system ATP-binding protein RfbE 1368..2117 Rickettsia africae ESF-5 7815852 YP_002844735.1 CDS rfbA NC_012633.1 2118 2894 D O-antigen export system permease protein RfbA 2118..2894 Rickettsia africae ESF-5 7815853 YP_002844736.1 CDS gltD NC_012633.1 2891 5992 D undetermined function; putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase 2891..5992 Rickettsia africae ESF-5 7815854 YP_002844737.1 CDS RAF_ORF0006 NC_012633.1 6036 6278 R hypothetical protein complement(6036..6278) Rickettsia africae ESF-5 7815855 YP_002844738.1 CDS RAF_ORF0007 NC_012633.1 6300 6581 R hypothetical protein complement(6300..6581) Rickettsia africae ESF-5 7815856 YP_002844739.1 CDS lpxA NC_012633.1 6612 7406 R catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase complement(6612..7406) Rickettsia africae ESF-5 7815857 YP_002844740.1 CDS fabZ NC_012633.1 7414 7851 R in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase complement(7414..7851) Rickettsia africae ESF-5 7815858 YP_002844741.1 CDS lpxD NC_012633.1 8047 9087 R adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase complement(8047..9087) Rickettsia africae ESF-5 7815859 YP_002844742.1 CDS dus NC_012633.1 9920 10939 D Putative dihydrouridine synthase Dus 9920..10939 Rickettsia africae ESF-5 7815861 YP_002844743.1 CDS RAF_ORF0012 NC_012633.1 11287 11886 D hypothetical protein 11287..11886 Rickettsia africae ESF-5 7815862 YP_002844744.1 CDS RAF_ORF0013 NC_012633.1 12135 12662 R Putative P-loop hydrolase complement(12135..12662) Rickettsia africae ESF-5 7815863 YP_002844745.1 CDS znuA NC_012633.1 12650 13603 R Zinc/manganese ABC transporter substrate binding protein complement(12650..13603) Rickettsia africae ESF-5 7815864 YP_002844746.1 CDS pcnB NC_012633.1 13600 14910 R Poly(A) polymerase complement(13600..14910) Rickettsia africae ESF-5 7815865 YP_002844747.1 CDS RAF_ORF0018 NC_012633.1 16456 16704 R ComEC/Rec2 family protein complement(16456..16704) Rickettsia africae ESF-5 7815867 YP_002844748.1 CDS sca1 NC_012633.1 17347 22914 D Cell surface antigen Sca1 17347..22914 Rickettsia africae ESF-5 7815868 YP_002844749.1 CDS RAF_ORF0020 NC_012633.1 23387 23635 D hypothetical protein 23387..23635 Rickettsia africae ESF-5 7815870 YP_002844750.1 CDS RAF_ORF0021 NC_012633.1 24260 24886 D hypothetical protein 24260..24886 Rickettsia africae ESF-5 7815871 YP_002844751.1 CDS atpF NC_012633.1 26098 26592 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(26098..26592) Rickettsia africae ESF-5 7815872 YP_002844752.1 CDS atpX NC_012633.1 26592 27065 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel.; F0F1 ATP synthase subunit B' complement(26592..27065) Rickettsia africae ESF-5 7815873 YP_002844753.1 CDS atpE NC_012633.1 27084 27308 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(27084..27308) Rickettsia africae ESF-5 7815874 YP_002844754.1 CDS atpB NC_012633.1 27504 28232 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(27504..28232) Rickettsia africae ESF-5 7815875 YP_002844755.1 CDS RAF_ORF0026 NC_012633.1 28237 28500 R hypothetical protein complement(28237..28500) Rickettsia africae ESF-5 7815876 YP_002844756.1 CDS dsbG NC_012633.1 28611 29444 R Protein-disulfide isomerase complement(28611..29444) Rickettsia africae ESF-5 7815877 YP_002844757.1 CDS RAF_ORF0028 NC_012633.1 29608 30129 D Transcriptional regulator 29608..30129 Rickettsia africae ESF-5 7815878 YP_002844758.1 CDS RAF_ORF0029 NC_012633.1 30376 31980 R Putative methyltransferase complement(30376..31980) Rickettsia africae ESF-5 7815879 YP_002844759.1 CDS recF NC_012633.1 32406 33488 R Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F complement(32406..33488) Rickettsia africae ESF-5 7815880 YP_002844760.1 CDS folA NC_012633.1 34147 34641 R Dihydrofolate reductase complement(34147..34641) Rickettsia africae ESF-5 7815881 YP_002844761.1 CDS RAF_ORF0035 NC_012633.1 36402 37070 R hypothetical protein complement(36402..37070) Rickettsia africae ESF-5 7815883 YP_002844762.1 CDS RAF_ORF0036 NC_012633.1 37128 37451 R hypothetical protein complement(37128..37451) Rickettsia africae ESF-5 7815884 YP_002844763.1 CDS RAF_ORF0040 NC_012633.1 39932 40363 D Sco2 protein precursor 39932..40363 Rickettsia africae ESF-5 7815886 YP_002844764.1 CDS RAF_ORF0041 NC_012633.1 40539 41108 R hypothetical protein complement(40539..41108) Rickettsia africae ESF-5 7815887 YP_002844765.1 CDS cvpA NC_012633.1 41174 41842 D Putative colicin V production membrane protein 41174..41842 Rickettsia africae ESF-5 7815888 YP_002844766.1 CDS RAF_ORF0045 NC_012633.1 43816 45138 R hypothetical protein complement(43816..45138) Rickettsia africae ESF-5 7815890 YP_002844767.1 CDS RAF_ORF0046 NC_012633.1 45148 45672 R hypothetical protein complement(45148..45672) Rickettsia africae ESF-5 7815891 YP_002844768.1 CDS RAF_ORF0047 NC_012633.1 45749 46327 R hypothetical protein complement(45749..46327) Rickettsia africae ESF-5 7815892 YP_002844769.1 CDS phbB NC_012633.1 47110 47835 R catalyzes the conversion of 3-hydroxyacyl-CoA to 3-oxyacyl-CoA; acetoacetyl-CoA reductase complement(47110..47835) Rickettsia africae ESF-5 7815893 YP_002844770.1 CDS clpB NC_012633.1 49865 52438 D chaperone ClpB 49865..52438 Rickettsia africae ESF-5 7815895 YP_002844771.1 CDS RAF_ORF0053 NC_012633.1 52622 53113 R hypothetical protein complement(52622..53113) Rickettsia africae ESF-5 7815896 YP_002844772.1 CDS gcp NC_012633.1 53240 54274 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease complement(53240..54274) Rickettsia africae ESF-5 7815897 YP_002844773.1 CDS aco1 NC_012633.1 54457 55650 R Acyl-CoA desaturase 1 complement(54457..55650) Rickettsia africae ESF-5 7815898 YP_002844774.1 CDS RAF_ORF0056 NC_012633.1 55798 56109 R Response regulator complement(55798..56109) Rickettsia africae ESF-5 7815899 YP_002844775.1 CDS rpsF NC_012633.1 56531 56968 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 56531..56968 Rickettsia africae ESF-5 7815900 YP_002844776.1 CDS rpsR NC_012633.1 56993 57280 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 56993..57280 Rickettsia africae ESF-5 7815901 YP_002844777.1 CDS rplI NC_012633.1 57292 57807 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 57292..57807 Rickettsia africae ESF-5 7815902 YP_002844778.1 CDS tilS NC_012633.1 58106 59542 D mesJ; tRNA(Ile)-lysidine synthetase 58106..59542 Rickettsia africae ESF-5 7815903 YP_002844779.1 CDS ftsH NC_012633.1 59643 61556 D ATP-dependent metalloprotease FtsH 59643..61556 Rickettsia africae ESF-5 7815904 YP_002844780.1 CDS RAF_ORF0062 NC_012633.1 61645 61842 D Site-specific DNA methylase 61645..61842 Rickettsia africae ESF-5 7815905 YP_002844781.1 CDS sdhB NC_012633.1 62463 63248 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 62463..63248 Rickettsia africae ESF-5 7815906 YP_002844782.1 CDS RAF_ORF0064 NC_012633.1 63323 63691 D hypothetical protein 63323..63691 Rickettsia africae ESF-5 7815907 YP_002844783.1 CDS RAF_ORF0065 NC_012633.1 63834 65054 R hypothetical protein complement(63834..65054) Rickettsia africae ESF-5 7815908 YP_002844784.1 CDS lgt NC_012633.1 65033 65812 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(65033..65812) Rickettsia africae ESF-5 7815909 YP_002844785.1 CDS RAF_ORF0067 NC_012633.1 66057 67220 D hypothetical protein 66057..67220 Rickettsia africae ESF-5 7815910 YP_002844786.1 CDS yidC NC_012633.1 67404 69086 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 67404..69086 Rickettsia africae ESF-5 7815911 YP_002844787.1 CDS pgsA NC_012633.1 69086 69631 D CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 69086..69631 Rickettsia africae ESF-5 7815912 YP_002844788.1 CDS RAF_ORF0070 NC_012633.1 69709 69921 R hypothetical protein complement(69709..69921) Rickettsia africae ESF-5 7815913 YP_002844789.1 CDS RAF_ORF0071 NC_012633.1 69965 70204 D hypothetical protein 69965..70204 Rickettsia africae ESF-5 7815914 YP_002844790.1 CDS RAF_ORF0072 NC_012633.1 70374 70793 R hypothetical protein complement(70374..70793) Rickettsia africae ESF-5 7815915 YP_002844791.1 CDS RAF_ORF0073 NC_012633.1 70977 71249 D Tellurite resistance protein-related protein 70977..71249 Rickettsia africae ESF-5 7815916 YP_002844792.1 CDS RAF_ORF0074 NC_012633.1 71813 72661 D hypothetical protein 71813..72661 Rickettsia africae ESF-5 7815917 YP_002844793.1 CDS def3 NC_012633.1 72879 73553 R Polypeptide deformylase complement(72879..73553) Rickettsia africae ESF-5 7815918 YP_002844794.1 CDS tlc1 NC_012633.1 73752 75257 D ATP/ADP translocase 73752..75257 Rickettsia africae ESF-5 7815919 YP_002844795.1 CDS uhpC NC_012633.1 75316 76611 D Sugar phosphate permease 75316..76611 Rickettsia africae ESF-5 7815920 YP_002844796.1 CDS ndk NC_012633.1 76636 77058 D catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 76636..77058 Rickettsia africae ESF-5 7815921 YP_002844797.1 CDS gidA NC_012633.1 77062 78930 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 77062..78930 Rickettsia africae ESF-5 7815922 YP_002844798.1 CDS gidB NC_012633.1 78911 79489 D glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 78911..79489 Rickettsia africae ESF-5 7815923 YP_002844799.1 CDS soj NC_012633.1 79486 80253 D chromosome partitioning ATPase 79486..80253 Rickettsia africae ESF-5 7815924 YP_002844800.1 CDS RAF_ORF0082 NC_012633.1 80240 81100 D ParB-like partition protein 80240..81100 Rickettsia africae ESF-5 7815925 YP_002844801.1 CDS abcT1 NC_012633.1 81358 83025 D ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 81358..83025 Rickettsia africae ESF-5 7815926 YP_002844802.1 CDS RAF_ORF0084 NC_012633.1 83028 83345 D hypothetical protein 83028..83345 Rickettsia africae ESF-5 7815927 YP_002844803.1 CDS kdsA NC_012633.1 83381 84205 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 83381..84205 Rickettsia africae ESF-5 7815928 YP_002844804.1 CDS RAF_ORF0086 NC_012633.1 84933 85400 D hypothetical protein 84933..85400 Rickettsia africae ESF-5 7815929 YP_002844805.1 CDS iscA1 NC_012633.1 85967 86299 R Iron-sulfur cluster assembly accessory protein complement(85967..86299) Rickettsia africae ESF-5 7815338 YP_002844806.1 CDS dgt NC_012633.1 86529 87683 D dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 86529..87683 Rickettsia africae ESF-5 7815339 YP_002844807.1 CDS argS NC_012633.1 87835 89565 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 87835..89565 Rickettsia africae ESF-5 7815340 YP_002844808.1 CDS RAF_ORF0090 NC_012633.1 89738 90412 D hypothetical protein 89738..90412 Rickettsia africae ESF-5 7815341 YP_002844809.1 CDS RAF_ORF0091 NC_012633.1 90431 90562 R hypothetical protein complement(90431..90562) Rickettsia africae ESF-5 7815342 YP_002844810.1 CDS parC NC_012633.1 90590 92806 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 90590..92806 Rickettsia africae ESF-5 7815343 YP_002844811.1 CDS RAF_ORF0093 NC_012633.1 92798 93046 R hypothetical protein complement(92798..93046) Rickettsia africae ESF-5 7815344 YP_002844812.1 CDS RAF_ORF0094 NC_012633.1 93399 94715 R hypothetical protein complement(93399..94715) Rickettsia africae ESF-5 7815345 YP_002844813.1 CDS dcd NC_012633.1 94987 95553 D Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 94987..95553 Rickettsia africae ESF-5 7815346 YP_002844814.1 CDS secB NC_012633.1 95599 96057 D molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 95599..96057 Rickettsia africae ESF-5 7815347 YP_002844815.1 CDS czcR NC_012633.1 96276 96989 D Transcriptional activator protein CzcR 96276..96989 Rickettsia africae ESF-5 7815348 YP_002844816.1 CDS queF NC_012633.1 96993 97814 D catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 96993..97814 Rickettsia africae ESF-5 7815349 YP_002844817.1 CDS RAF_ORF0099 NC_012633.1 98059 98619 R hypothetical protein complement(98059..98619) Rickettsia africae ESF-5 7815350 YP_002844818.1 CDS pntB NC_012633.1 98674 100071 R NAD(p) transhydrogenase subunit beta complement(98674..100071) Rickettsia africae ESF-5 7815351 YP_002844819.1 CDS ompW NC_012633.1 100212 100946 R OmpW family outer-membrane protein complement(100212..100946) Rickettsia africae ESF-5 7815352 YP_002844820.1 CDS sam NC_012633.1 101101 101985 D S-adenosylmethionine transporter 101101..101985 Rickettsia africae ESF-5 7815353 YP_002844821.1 CDS proP1 NC_012633.1 101972 103228 D Proline/betaine transporter 101972..103228 Rickettsia africae ESF-5 7815354 YP_002844822.1 CDS secG NC_012633.1 104062 104364 D preprotein translocase subunit SecG 104062..104364 Rickettsia africae ESF-5 7815356 YP_002844823.1 CDS sca2 NC_012633.1 105266 111067 R Cell surface antigen Sca2 complement(105266..111067) Rickettsia africae ESF-5 7815357 YP_002844824.1 CDS cysS NC_012633.1 111304 112683 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 111304..112683 Rickettsia africae ESF-5 7815358 YP_002844825.1 CDS rpsB NC_012633.1 112930 113817 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 112930..113817 Rickettsia africae ESF-5 7815359 YP_002844826.1 CDS tsf NC_012633.1 114014 114943 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 114014..114943 Rickettsia africae ESF-5 7815360 YP_002844827.1 CDS RAF_ORF0109 NC_012633.1 115416 115748 D hypothetical protein 115416..115748 Rickettsia africae ESF-5 7815361 YP_002844828.1 CDS kdtA NC_012633.1 116460 117854 R catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase complement(116460..117854) Rickettsia africae ESF-5 7815362 YP_002844829.1 CDS RAF_ORF0111 NC_012633.1 117851 118507 R hypothetical protein complement(117851..118507) Rickettsia africae ESF-5 7815363 YP_002844830.1 CDS aatA NC_012633.1 118658 119863 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(118658..119863) Rickettsia africae ESF-5 7815364 YP_002844831.1 CDS RAF_ORF0113 NC_012633.1 120524 121528 D hypothetical protein 120524..121528 Rickettsia africae ESF-5 7815365 YP_002844832.1 CDS vacJ NC_012633.1 121533 122288 D VacJ lipoprotein precursor 121533..122288 Rickettsia africae ESF-5 7815366 YP_002844833.1 CDS RAF_ORF0115 NC_012633.1 122308 122907 D ABC-type transporter related to toluene tolerance 122308..122907 Rickettsia africae ESF-5 7815367 YP_002844834.1 CDS alr NC_012633.1 124151 125218 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 124151..125218 Rickettsia africae ESF-5 7815369 YP_002844835.1 CDS RAF_ORF0119 NC_012633.1 125364 126143 D ABC transporter permease 125364..126143 Rickettsia africae ESF-5 7815370 YP_002844836.1 CDS mkl NC_012633.1 126297 127052 D Ribonucleotide ABC transporter ATP-binding protein 126297..127052 Rickettsia africae ESF-5 7815371 YP_002844837.1 CDS RAF_ORF0121 NC_012633.1 127054 127302 D hypothetical protein 127054..127302 Rickettsia africae ESF-5 7815372 YP_002844838.1 CDS RAF_ORF0122 NC_012633.1 127867 128163 R hypothetical protein complement(127867..128163) Rickettsia africae ESF-5 7815373 YP_002844839.1 CDS RAF_ORF0123 NC_012633.1 128471 128842 R hypothetical protein complement(128471..128842) Rickettsia africae ESF-5 7815374 YP_002844840.1 CDS rpmB NC_012633.1 129752 130045 D required for 70S ribosome assembly; 50S ribosomal protein L28 129752..130045 Rickettsia africae ESF-5 7815375 YP_002844841.1 CDS rpmE NC_012633.1 130042 130278 D RpmE; RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 130042..130278 Rickettsia africae ESF-5 7815376 YP_002844842.1 CDS engB NC_012633.1 130886 131524 D binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 130886..131524 Rickettsia africae ESF-5 7815378 YP_002844843.1 CDS argB NC_012633.1 131472 132395 D Acetylglutamate kinase 131472..132395 Rickettsia africae ESF-5 7815379 YP_002844844.1 CDS virB3 NC_012633.1 132408 132695 D type IV secretion system protein VirB3 132408..132695 Rickettsia africae ESF-5 7815380 YP_002844845.1 CDS virB4-1 NC_012633.1 132785 135202 D type IV secretion system ATPase VirB4 132785..135202 Rickettsia africae ESF-5 7815381 YP_002844846.1 CDS virB6-1 NC_012633.1 135320 138439 D VirB6 135320..138439 Rickettsia africae ESF-5 7815382 YP_002844847.1 CDS virB6-3 NC_012633.1 140419 143319 D VirB6 140419..143319 Rickettsia africae ESF-5 7815384 YP_002844848.1 CDS virB6-4 NC_012633.1 143493 146168 D VirB6 143493..146168 Rickettsia africae ESF-5 7815385 YP_002844849.1 CDS virB6-5 NC_012633.1 146321 149782 D VirB6 146321..149782 Rickettsia africae ESF-5 7815386 YP_002844850.1 CDS trmD NC_012633.1 153126 153830 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 153126..153830 Rickettsia africae ESF-5 7815389 YP_002844851.1 CDS rplS NC_012633.1 153848 154264 D this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 153848..154264 Rickettsia africae ESF-5 7815390 YP_002844852.1 CDS RAF_ORF0142 NC_012633.1 154434 154670 R hypothetical protein complement(154434..154670) Rickettsia africae ESF-5 7815391 YP_002844853.1 CDS secF NC_012633.1 154743 155669 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 154743..155669 Rickettsia africae ESF-5 7815392 YP_002844854.1 CDS nuoF NC_012633.1 155834 157099 D part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 155834..157099 Rickettsia africae ESF-5 7815393 YP_002844855.1 CDS lepB NC_012633.1 157283 158083 D Signal peptidase I 157283..158083 Rickettsia africae ESF-5 7815394 YP_002844856.1 CDS rnc NC_012633.1 158083 158766 D cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 158083..158766 Rickettsia africae ESF-5 7815395 YP_002844857.1 CDS era NC_012633.1 158759 159778 D GTP-binding protein Era 158759..159778 Rickettsia africae ESF-5 7815396 YP_002844858.1 CDS ruvC NC_012633.1 159895 160368 D endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 159895..160368 Rickettsia africae ESF-5 7815397 YP_002844859.1 CDS RAF_ORF0149 NC_012633.1 160370 161062 D tRNA/rRNA methyltransferase 160370..161062 Rickettsia africae ESF-5 7815398 YP_002844860.1 CDS RAF_ORF0150 NC_012633.1 161043 161648 R nucleotidyltransferase substrate binding protein complement(161043..161648) Rickettsia africae ESF-5 7815399 YP_002844861.1 CDS RAF_ORF0151 NC_012633.1 161708 162754 R Putative nucleoside-diphosphate-sugar epimerase complement(161708..162754) Rickettsia africae ESF-5 7815400 YP_002844862.1 CDS mrp NC_012633.1 162751 163710 R hypothetical protein complement(162751..163710) Rickettsia africae ESF-5 7815401 YP_002844863.1 CDS hflK NC_012633.1 163815 164855 D Protease activity modulator HflK 163815..164855 Rickettsia africae ESF-5 7815402 YP_002844864.1 CDS hflC2 NC_012633.1 164948 165808 D Membrane protease subunit, stomatin/prohibitin-like protein 164948..165808 Rickettsia africae ESF-5 7815403 YP_002844865.1 CDS htrA NC_012633.1 165846 167324 D Periplasmic serine protease 165846..167324 Rickettsia africae ESF-5 7815404 YP_002844866.1 CDS RAF_ORF0156 NC_012633.1 167501 168244 D hypothetical protein 167501..168244 Rickettsia africae ESF-5 7815405 YP_002844867.1 CDS sdhC NC_012633.1 168411 168785 D Succinate dehydrogenase cytochrome b-556 subunit 168411..168785 Rickettsia africae ESF-5 7815406 YP_002844868.1 CDS sdhD NC_012633.1 168930 169310 D Succinate dehydrogenase hydrophobic membrane anchor protein 168930..169310 Rickettsia africae ESF-5 7815407 YP_002844869.1 CDS sdhA NC_012633.1 169444 171234 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 169444..171234 Rickettsia africae ESF-5 7815408 YP_002844870.1 CDS yqiY NC_012633.1 171382 172038 D amino acid ABC transporter permease 171382..172038 Rickettsia africae ESF-5 7815409 YP_002844871.1 CDS rpsL NC_012633.1 172199 172588 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 172199..172588 Rickettsia africae ESF-5 7815410 YP_002844872.1 CDS rpsG NC_012633.1 172615 173097 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 172615..173097 Rickettsia africae ESF-5 7815411 YP_002844873.1 CDS fusA NC_012633.1 173109 175208 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 173109..175208 Rickettsia africae ESF-5 7815412 YP_002844874.1 CDS secE NC_012633.1 175628 175828 D forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 175628..175828 Rickettsia africae ESF-5 7815414 YP_002844875.1 CDS nusG NC_012633.1 175844 176422 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 175844..176422 Rickettsia africae ESF-5 7815415 YP_002844876.1 CDS rplK NC_012633.1 176694 177131 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 176694..177131 Rickettsia africae ESF-5 7815416 YP_002844877.1 CDS rplA NC_012633.1 177137 177856 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 177137..177856 Rickettsia africae ESF-5 7815417 YP_002844878.1 CDS rplJ NC_012633.1 177967 178476 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 177967..178476 Rickettsia africae ESF-5 7815176 YP_002844879.1 CDS rplL NC_012633.1 178676 179053 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 178676..179053 Rickettsia africae ESF-5 7815177 YP_002844880.1 CDS rpoB NC_012633.1 179998 184119 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 179998..184119 Rickettsia africae ESF-5 7815178 YP_002844881.1 CDS rpoC NC_012633.1 184377 188495 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 184377..188495 Rickettsia africae ESF-5 7815179 YP_002844882.1 CDS RAF_ORF0172 NC_012633.1 188902 190071 R hypothetical protein complement(188902..190071) Rickettsia africae ESF-5 7815180 YP_002844883.1 CDS pepA NC_012633.1 190240 191742 D catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 190240..191742 Rickettsia africae ESF-5 7815181 YP_002844884.1 CDS RAF_ORF0174 NC_012633.1 191961 192761 D Chromosome partitioning protein-like protein 191961..192761 Rickettsia africae ESF-5 7815182 YP_002844885.1 CDS RAF_ORF0175 NC_012633.1 192844 193278 D hypothetical protein 192844..193278 Rickettsia africae ESF-5 7815183 YP_002844886.1 CDS aspS NC_012633.1 193369 195177 D catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 193369..195177 Rickettsia africae ESF-5 7815184 YP_002844887.1 CDS RAF_ORF0177 NC_012633.1 195455 197569 R hypothetical protein complement(195455..197569) Rickettsia africae ESF-5 7815185 YP_002844888.1 CDS RAF_ORF0178 NC_012633.1 197953 198663 R Integral membrane protein, interacts with FtsH complement(197953..198663) Rickettsia africae ESF-5 7815186 YP_002844889.1 CDS dapB NC_012633.1 198737 199456 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(198737..199456) Rickettsia africae ESF-5 7815187 YP_002844890.1 CDS RAF_ORF0180 NC_012633.1 199478 199957 R Flavoprotein oxygenase DIM6/NTAB family protein complement(199478..199957) Rickettsia africae ESF-5 7815188 YP_002844891.1 CDS yqiX NC_012633.1 199942 200667 R amino acid ABC transporter substrate-binding protein complement(199942..200667) Rickettsia africae ESF-5 7815189 YP_002844892.1 CDS gatB NC_012633.1 200878 202329 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(200878..202329) Rickettsia africae ESF-5 7815190 YP_002844893.1 CDS gatA NC_012633.1 202332 203813 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(202332..203813) Rickettsia africae ESF-5 7815191 YP_002844894.1 CDS gatC NC_012633.1 203816 204118 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(203816..204118) Rickettsia africae ESF-5 7815192 YP_002844895.1 CDS RAF_ORF0185 NC_012633.1 204420 204593 R hypothetical protein complement(204420..204593) Rickettsia africae ESF-5 7815193 YP_002844896.1 CDS frr NC_012633.1 204908 205468 R Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor complement(204908..205468) Rickettsia africae ESF-5 7815194 YP_002844897.1 CDS pyrH NC_012633.1 205757 206485 R Catalyzes the phosphorylation of UMP to UDP; uridylate kinase complement(205757..206485) Rickettsia africae ESF-5 7815195 YP_002844898.1 CDS mnhE NC_012633.1 206494 206817 R subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit E complement(206494..206817) Rickettsia africae ESF-5 7815196 YP_002844899.1 CDS emrB NC_012633.1 206801 208360 R MFS-type multidrug resistance protein B complement(206801..208360) Rickettsia africae ESF-5 7815197 YP_002844900.1 CDS RAF_ORF0190 NC_012633.1 208592 208795 D hypothetical protein 208592..208795 Rickettsia africae ESF-5 7815198 YP_002844901.1 CDS RAF_ORF0191 NC_012633.1 209171 209419 R hypothetical protein complement(209171..209419) Rickettsia africae ESF-5 7815199 YP_002844902.1 CDS RAF_ORF0192 NC_012633.1 209421 210008 R hypothetical protein complement(209421..210008) Rickettsia africae ESF-5 7815200 YP_002844903.1 CDS omp1 NC_012633.1 210706 213012 R Outer membrane protein omp1 complement(210706..213012) Rickettsia africae ESF-5 7815202 YP_002844904.1 CDS RAF_ORF0194 NC_012633.1 213251 214324 R Putative membrane-associated zinc metalloprotease complement(213251..214324) Rickettsia africae ESF-5 7815203 YP_002844905.1 CDS nusB NC_012633.1 214606 215076 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 214606..215076 Rickettsia africae ESF-5 7815204 YP_002844906.1 CDS rrmJ NC_012633.1 215211 215894 D Ribosomal RNA large subunit methyltransferase J 215211..215894 Rickettsia africae ESF-5 7815205 YP_002844907.1 CDS RAF_ORF0197 NC_012633.1 215945 217006 R hypothetical protein complement(215945..217006) Rickettsia africae ESF-5 7815206 YP_002844908.1 CDS RAF_ORF0198 NC_012633.1 217171 218124 D hypothetical protein 217171..218124 Rickettsia africae ESF-5 7815207 YP_002844909.1 CDS RAF_ORF0199 NC_012633.1 218183 218623 R Oligoketide cyclase/lipid transport protein complement(218183..218623) Rickettsia africae ESF-5 7815208 YP_002844910.1 CDS RAF_ORF0200 NC_012633.1 218623 218904 R hypothetical protein complement(218623..218904) Rickettsia africae ESF-5 7815209 YP_002844911.1 CDS RAF_ORF0201 NC_012633.1 218917 219657 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 218917..219657 Rickettsia africae ESF-5 7815210 YP_002844912.1 CDS RAF_ORF0202 NC_012633.1 219739 219975 R hypothetical protein complement(219739..219975) Rickettsia africae ESF-5 7815211 YP_002844913.1 CDS acrF NC_012633.1 220230 223256 R Hydrophobe/amphiphile efflux-1 (HAE1) family protein complement(220230..223256) Rickettsia africae ESF-5 7815212 YP_002844914.1 CDS hupA NC_012633.1 223648 224064 D DNA-binding protein HU 223648..224064 Rickettsia africae ESF-5 7815213 YP_002844915.1 CDS holB NC_012633.1 224219 225013 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 224219..225013 Rickettsia africae ESF-5 7815214 YP_002844916.1 CDS ffh NC_012633.1 225220 226569 D Signal recognition particle protein 225220..226569 Rickettsia africae ESF-5 7815215 YP_002844917.1 CDS hemN NC_012633.1 229311 230513 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 229311..230513 Rickettsia africae ESF-5 7815217 YP_002844918.1 CDS RAF_ORF0213 NC_012633.1 230735 231121 D Ankyrin repeat protein 230735..231121 Rickettsia africae ESF-5 7815218 YP_002844919.1 CDS cmcI NC_012633.1 231661 231993 R cephalosporin hydroxylase complement(231661..231993) Rickettsia africae ESF-5 7815219 YP_002844920.1 CDS gltP NC_012633.1 232426 233625 R Na+/H+-dicarboxylate symporter complement(232426..233625) Rickettsia africae ESF-5 7815220 YP_002844921.1 CDS cutA NC_012633.1 233666 233980 R Periplasmic divalent cation tolerance protein complement(233666..233980) Rickettsia africae ESF-5 7815221 YP_002844922.1 CDS RAF_ORF0217 NC_012633.1 233983 234501 R 6-pyruvoyl-tetrahydropterin synthase complement(233983..234501) Rickettsia africae ESF-5 7815222 YP_002844923.1 CDS sucB NC_012633.1 234569 235756 R component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase complement(234569..235756) Rickettsia africae ESF-5 7815223 YP_002844924.1 CDS sucA NC_012633.1 235921 238707 R SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component complement(235921..238707) Rickettsia africae ESF-5 7815224 YP_002844925.1 CDS RAF_ORF0220 NC_012633.1 238841 240331 R Thermostable carboxypeptidase complement(238841..240331) Rickettsia africae ESF-5 7815225 YP_002844926.1 CDS recN NC_012633.1 240508 242145 R DNA repair protein RecN complement(240508..242145) Rickettsia africae ESF-5 7815226 YP_002844927.1 CDS comL NC_012633.1 242153 242908 R DNA uptake lipoprotein complement(242153..242908) Rickettsia africae ESF-5 7815227 YP_002844928.1 CDS chaB NC_012633.1 243149 243310 R Cation transport regulator ChaB complement(243149..243310) Rickettsia africae ESF-5 7815228 YP_002844929.1 CDS dnaJ NC_012633.1 243447 244568 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ complement(243447..244568) Rickettsia africae ESF-5 7815229 YP_002844930.1 CDS dnaK NC_012633.1 244697 246580 R heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK complement(244697..246580) Rickettsia africae ESF-5 7815230 YP_002844931.1 CDS RAF_ORF0226 NC_012633.1 246644 248137 D Heat shock protease 246644..248137 Rickettsia africae ESF-5 7815231 YP_002844932.1 CDS RAF_ORF0227 NC_012633.1 249297 249644 R hypothetical protein complement(249297..249644) Rickettsia africae ESF-5 7815232 YP_002844933.1 CDS RAF_ORF0228 NC_012633.1 249813 250286 D hypothetical protein 249813..250286 Rickettsia africae ESF-5 7815233 YP_002844934.1 CDS holA NC_012633.1 250294 251268 D required for the assembly and function of the DNAX complex which are required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 250294..251268 Rickettsia africae ESF-5 7815234 YP_002844935.1 CDS coq7 NC_012633.1 251416 251955 D Ubiquinone biosynthesis protein coq7 251416..251955 Rickettsia africae ESF-5 7815235 YP_002844936.1 CDS coxC NC_012633.1 252431 253357 D Cytochrome c oxidase subunit III 252431..253357 Rickettsia africae ESF-5 7815236 YP_002844937.1 CDS virB2 NC_012633.1 253513 253869 D VirB2-like protein 253513..253869 Rickettsia africae ESF-5 7815237 YP_002844938.1 CDS RAF_ORF0233 NC_012633.1 254213 254851 R hypothetical protein complement(254213..254851) Rickettsia africae ESF-5 7815238 YP_002844939.1 CDS dapD NC_012633.1 254927 255751 D catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 254927..255751 Rickettsia africae ESF-5 7815239 YP_002844940.1 CDS pbpC NC_012633.1 257804 260062 R Bifunctional penicillin-binding protein 1C complement(257804..260062) Rickettsia africae ESF-5 7815241 YP_002844941.1 CDS uspA NC_012633.1 265202 265648 R Universal stress protein UspA-like nucleotide-binding protein complement(265202..265648) Rickettsia africae ESF-5 7815243 YP_002844942.1 CDS imp NC_012633.1 265658 266599 R TRAP-type transport system, periplasmic protein complement(265658..266599) Rickettsia africae ESF-5 7815244 YP_002844943.1 CDS RAF_ORF0243 NC_012633.1 266604 267674 R hypothetical protein complement(266604..267674) Rickettsia africae ESF-5 7815245 YP_002844944.1 CDS fdxB NC_012633.1 267687 268025 R Ferredoxin complement(267687..268025) Rickettsia africae ESF-5 7815246 YP_002844945.1 CDS hscA NC_012633.1 268089 269876 R involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(268089..269876) Rickettsia africae ESF-5 7815247 YP_002844946.1 CDS hscB NC_012633.1 269867 270367 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(269867..270367) Rickettsia africae ESF-5 7815248 YP_002844947.1 CDS rnhB NC_012633.1 270429 271010 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 270429..271010 Rickettsia africae ESF-5 7815249 YP_002844948.1 CDS uvrB NC_012633.1 271164 273149 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(271164..273149) Rickettsia africae ESF-5 7815250 YP_002844949.1 CDS grxC1 NC_012633.1 273220 273528 D Glutaredoxin, GrxC family 273220..273528 Rickettsia africae ESF-5 7815251 YP_002844950.1 CDS gyrA NC_012633.1 276521 279238 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 276521..279238 Rickettsia africae ESF-5 7815253 YP_002844951.1 CDS RAF_ORF0256 NC_012633.1 281251 281436 D hypothetical protein 281251..281436 Rickettsia africae ESF-5 7815255 YP_002844952.1 CDS def NC_012633.1 281890 282417 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 281890..282417 Rickettsia africae ESF-5 7815850 YP_002844953.1 CDS fmt NC_012633.1 282414 283325 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 282414..283325 Rickettsia africae ESF-5 7815258 YP_002844954.1 CDS RAF_ORF0259 NC_012633.1 283495 283911 D hypothetical protein 283495..283911 Rickettsia africae ESF-5 7815259 YP_002844955.1 CDS n2B NC_012633.1 288457 289509 R Putative ATPase n2B complement(288457..289509) Rickettsia africae ESF-5 7815263 YP_002844956.1 CDS queA NC_012633.1 289724 290821 R S-adenosylmethionine--tRNA ribosyltransferase-isomerase complement(289724..290821) Rickettsia africae ESF-5 7815264 YP_002844957.1 CDS RAF_ORF0264 NC_012633.1 291057 291338 D Ankyrin repeat protein 291057..291338 Rickettsia africae ESF-5 7815265 YP_002844958.1 CDS RAF_ORF0265 NC_012633.1 291728 292120 D hypothetical protein 291728..292120 Rickettsia africae ESF-5 7815266 YP_002844959.1 CDS abcT3 NC_012633.1 292188 293957 R Multidrug resistance ABC transporter ATP-binding protein complement(292188..293957) Rickettsia africae ESF-5 7815267 YP_002844960.1 CDS RAF_ORF0267 NC_012633.1 294138 294410 D hypothetical protein 294138..294410 Rickettsia africae ESF-5 7815268 YP_002844961.1 CDS cydA NC_012633.1 294562 295932 D Cytochrome d ubiquinol oxidase subunit I 294562..295932 Rickettsia africae ESF-5 7815269 YP_002844962.1 CDS cydB NC_012633.1 295940 296959 D Cytochrome d ubiquinol oxidase subunit II 295940..296959 Rickettsia africae ESF-5 7815270 YP_002844963.1 CDS RAF_ORF0270 NC_012633.1 297161 297403 D Antitoxin of toxin-antitoxin (TA) system StbD 297161..297403 Rickettsia africae ESF-5 7815271 YP_002844964.1 CDS RAF_ORF0271 NC_012633.1 297414 297674 D Putative toxin of toxin-antitoxin (TA) system 297414..297674 Rickettsia africae ESF-5 7815272 YP_002844965.1 CDS lgtF NC_012633.1 297667 298515 D Beta 1,4 glucosyltransferase 297667..298515 Rickettsia africae ESF-5 7815273 YP_002844966.1 CDS mpp NC_012633.1 298592 299827 D similar to mitochondrial proteases; protease 298592..299827 Rickettsia africae ESF-5 7815274 YP_002844967.1 CDS purC NC_012633.1 299981 300691 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 299981..300691 Rickettsia africae ESF-5 7815275 YP_002844968.1 CDS RAF_ORF0275 NC_012633.1 301101 302498 D hypothetical protein 301101..302498 Rickettsia africae ESF-5 7815276 YP_002844969.1 CDS thrS NC_012633.1 302594 304501 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 302594..304501 Rickettsia africae ESF-5 7815277 YP_002844970.1 CDS RAF_ORF0281 NC_012633.1 307792 308208 R hypothetical protein complement(307792..308208) Rickettsia africae ESF-5 7815280 YP_002844971.1 CDS RAF_ORF0282 NC_012633.1 308239 308385 D hypothetical protein 308239..308385 Rickettsia africae ESF-5 7815281 YP_002844972.1 CDS RAF_ORF0283 NC_012633.1 308405 308887 R hypothetical protein complement(308405..308887) Rickettsia africae ESF-5 7815282 YP_002844973.1 CDS tolC NC_012633.1 309597 310958 D Type I secretion outer membrane protein TolC 309597..310958 Rickettsia africae ESF-5 7815283 YP_002844974.1 CDS RAF_ORF0285 NC_012633.1 310960 311358 D hypothetical protein 310960..311358 Rickettsia africae ESF-5 7815284 YP_002844975.1 CDS RAF_ORF0286 NC_012633.1 311575 313296 D Ankyrin repeat protein 311575..313296 Rickettsia africae ESF-5 7815285 YP_002844976.1 CDS parE NC_012633.1 313506 315494 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 313506..315494 Rickettsia africae ESF-5 7815286 YP_002844977.1 CDS ctp NC_012633.1 315610 316980 D Carboxyl-terminal protease 315610..316980 Rickettsia africae ESF-5 7815287 YP_002844978.1 CDS barA NC_012633.1 317195 318688 D Histidine kinase sensor protein 317195..318688 Rickettsia africae ESF-5 7815288 YP_002844979.1 CDS RAF_ORF0290 NC_012633.1 318754 319491 D hypothetical protein 318754..319491 Rickettsia africae ESF-5 7815289 YP_002844980.1 CDS RAF_ORF0291 NC_012633.1 319504 320166 D hypothetical protein 319504..320166 Rickettsia africae ESF-5 7815290 YP_002844981.1 CDS RAF_ORF0292 NC_012633.1 320189 321433 D WD40-like repeat protein 320189..321433 Rickettsia africae ESF-5 7815291 YP_002844982.1 CDS rplM NC_012633.1 321526 321993 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 321526..321993 Rickettsia africae ESF-5 7815292 YP_002844983.1 CDS rpsI NC_012633.1 322000 322479 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 322000..322479 Rickettsia africae ESF-5 7815293 YP_002844984.1 CDS RAF_ORF0295 NC_012633.1 323218 323418 D D-alanyl-D-alanine dipeptidase 323218..323418 Rickettsia africae ESF-5 7815295 YP_002844985.1 CDS RAF_ORF0296 NC_012633.1 324026 324319 D hypothetical protein 324026..324319 Rickettsia africae ESF-5 7815296 YP_002844986.1 CDS nudH NC_012633.1 324713 325198 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(324713..325198) Rickettsia africae ESF-5 7815297 YP_002844987.1 CDS pleD NC_012633.1 325223 326575 R involved in swarmer-to-stalked cell differentiation in Caulobacter crescentus; catalyzes the condensation of two GTP molecules to form the secondary messenger cyclic di-GMP (c-di-GMP); upon phosphorylation of domain D1 the protein dimerizes; presumably this allows the two GTP-bound GGDEF (diguanylate cyclase) domains to catalyze the condensation reaction; allosterically inhibited by c-di-GMP; response regulator PleD complement(325223..326575) Rickettsia africae ESF-5 7815298 YP_002844988.1 CDS efp NC_012633.1 326651 327217 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 326651..327217 Rickettsia africae ESF-5 7815299 YP_002844989.1 CDS suhB NC_012633.1 327439 328185 D Extragenic suppressor protein suhB 327439..328185 Rickettsia africae ESF-5 7815300 YP_002844990.1 CDS RAF_ORF0301 NC_012633.1 328257 328580 D hypothetical protein 328257..328580 Rickettsia africae ESF-5 7815301 YP_002844991.1 CDS psd NC_012633.1 328614 329309 D catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 328614..329309 Rickettsia africae ESF-5 7815302 YP_002844992.1 CDS pssA NC_012633.1 329572 330336 D CDP-diacylglycerol--serine O-phosphatidyltransferase 329572..330336 Rickettsia africae ESF-5 7815303 YP_002844993.1 CDS emrA NC_012633.1 330345 331397 D Multidrug resistance protein A 330345..331397 Rickettsia africae ESF-5 7815304 YP_002844994.1 CDS RAF_ORF0305 NC_012633.1 332215 332418 R hypothetical protein complement(332215..332418) Rickettsia africae ESF-5 7815305 YP_002844995.1 CDS bolA1 NC_012633.1 332415 332657 R BolA-like protein complement(332415..332657) Rickettsia africae ESF-5 7815306 YP_002844996.1 CDS RAF_ORF0307 NC_012633.1 332712 333938 D EAL domain containing protein 332712..333938 Rickettsia africae ESF-5 7815307 YP_002844997.1 CDS murC NC_012633.1 334159 335616 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 334159..335616 Rickettsia africae ESF-5 7815308 YP_002844998.1 CDS murB NC_012633.1 335712 336635 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 335712..336635 Rickettsia africae ESF-5 7815309 YP_002844999.1 CDS ddl NC_012633.1 336879 337844 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 336879..337844 Rickettsia africae ESF-5 7815310 YP_002845000.1 CDS ftsQ NC_012633.1 337841 338644 D Cell division protein ftsQ 337841..338644 Rickettsia africae ESF-5 7815311 YP_002845001.1 CDS ftsA NC_012633.1 338772 340007 D Cell division protein ftsA 338772..340007 Rickettsia africae ESF-5 7815312 YP_002845002.1 CDS RAF_ORF0313 NC_012633.1 340150 340626 R Membrane protein implicated in regulation of membrane protease activity complement(340150..340626) Rickettsia africae ESF-5 7815313 YP_002845003.1 CDS cycM NC_012633.1 340610 341137 R cytochrome C complement(340610..341137) Rickettsia africae ESF-5 7815314 YP_002845004.1 CDS RAF_ORF0315 NC_012633.1 341251 342321 D hypothetical protein 341251..342321 Rickettsia africae ESF-5 7815315 YP_002845005.1 CDS lpxC NC_012633.1 342330 343196 R zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase complement(342330..343196) Rickettsia africae ESF-5 7815316 YP_002845006.1 CDS RAF_ORF0317 NC_012633.1 343560 344708 R hypothetical protein complement(343560..344708) Rickettsia africae ESF-5 7815317 YP_002845007.1 CDS rne NC_012633.1 345136 347208 D Ribonuclease E 345136..347208 Rickettsia africae ESF-5 7815318 YP_002845008.1 CDS coxW NC_012633.1 347454 348467 D Cytochrome c oxidase assembly protein 347454..348467 Rickettsia africae ESF-5 7815319 YP_002845009.1 CDS rluA1 NC_012633.1 348480 349391 D Ribosomal large subunit pseudouridine synthase 348480..349391 Rickettsia africae ESF-5 7815320 YP_002845010.1 CDS pbpE NC_012633.1 349546 350727 D Penicillin-binding protein 4 349546..350727 Rickettsia africae ESF-5 7815321 YP_002845011.1 CDS xth1 NC_012633.1 350874 351689 D Exodeoxyribonuclease III 350874..351689 Rickettsia africae ESF-5 7815322 YP_002845012.1 CDS pdhA NC_012633.1 351712 352692 D Pyruvate dehydrogenase e1 component, alpha subunit precursor 351712..352692 Rickettsia africae ESF-5 7815323 YP_002845013.1 CDS pdhB NC_012633.1 352856 353836 D catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acyltransferase within the complex. The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2); it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase; pyruvate dehydrogenase subunit beta 352856..353836 Rickettsia africae ESF-5 7815324 YP_002845014.1 CDS typA NC_012633.1 353974 355803 R GTP-binding protein TypA complement(353974..355803) Rickettsia africae ESF-5 7815325 YP_002845015.1 CDS hlpA NC_012633.1 356897 357451 D Outer membrane protein 356897..357451 Rickettsia africae ESF-5 7815326 YP_002845016.1 CDS icd NC_012633.1 357633 359084 D catalyzes the formation of 2-oxoglutarate from isocitrate; isocitrate dehydrogenase 357633..359084 Rickettsia africae ESF-5 7815327 YP_002845017.1 CDS RAF_ORF0328 NC_012633.1 359199 359519 D subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport; putative monovalent cation/H+ antiporter subunit G 359199..359519 Rickettsia africae ESF-5 7815328 YP_002845018.1 CDS mnhB NC_012633.1 359583 360656 D subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit B 359583..360656 Rickettsia africae ESF-5 7815329 YP_002845019.1 CDS ccmB NC_012633.1 360649 361296 D Heme exporter protein B 360649..361296 Rickettsia africae ESF-5 7815330 YP_002845020.1 CDS RAF_ORF0331 NC_012633.1 361371 361829 D hypothetical protein 361371..361829 Rickettsia africae ESF-5 7815331 YP_002845021.1 CDS petA NC_012633.1 361851 362384 D Ubiquinol-cytochrome c reductase, iron-sulfur subunit 361851..362384 Rickettsia africae ESF-5 7815332 YP_002845022.1 CDS petB NC_012633.1 362391 363587 D Cytochrome b 362391..363587 Rickettsia africae ESF-5 7815333 YP_002845023.1 CDS fbcH NC_012633.1 364078 364833 D Cytochrome c1, heme protein precursor 364078..364833 Rickettsia africae ESF-5 7815334 YP_002845024.1 CDS hspC1 NC_012633.1 365624 366127 D Small heat shock protein 365624..366127 Rickettsia africae ESF-5 7815336 YP_002845025.1 CDS prfB NC_012633.1 368022 369128 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(368022..369128) Rickettsia africae ESF-5 7815257 YP_002845026.1 CDS lepA NC_012633.1 369247 371049 D binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 369247..371049 Rickettsia africae ESF-5 7815019 YP_002845027.1 CDS RAF_ORF0345 NC_012633.1 372002 372142 R Plasmid maintenance system antidote protein complement(372002..372142) Rickettsia africae ESF-5 7815021 YP_002845028.1 CDS RAF_ORF0348 NC_012633.1 374644 375240 D hypothetical protein 374644..375240 Rickettsia africae ESF-5 7815023 YP_002845029.1 CDS spoT1 NC_012633.1 375575 375886 D Guanosine polyphosphate pyrophosphohydrolase/synthetase 375575..375886 Rickettsia africae ESF-5 7815024 YP_002845030.1 CDS RAF_ORF0350 NC_012633.1 376200 376532 D hypothetical protein 376200..376532 Rickettsia africae ESF-5 7815025 YP_002845031.1 CDS rodA NC_012633.1 376937 378037 R Rod shape-determining protein rodA complement(376937..378037) Rickettsia africae ESF-5 7815026 YP_002845032.1 CDS ptrB NC_012633.1 378193 380382 R Protease II complement(378193..380382) Rickettsia africae ESF-5 7815027 YP_002845033.1 CDS nuoL3 NC_012633.1 380561 382078 R subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; putative monovalent cation/H+ antiporter subunit D complement(380561..382078) Rickettsia africae ESF-5 7815028 YP_002845034.1 CDS vapB1 NC_012633.1 382476 382763 R Antitoxin of toxin-antitoxin (TA) system VapB complement(382476..382763) Rickettsia africae ESF-5 7815029 YP_002845035.1 CDS nuoL2 NC_012633.1 382950 384413 R subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; putative monovalent cation/H+ antiporter subunit D complement(382950..384413) Rickettsia africae ESF-5 7815030 YP_002845036.1 CDS nuoN2 NC_012633.1 384560 385861 R subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; putative monovalent cation/H+ antiporter subunit D complement(384560..385861) Rickettsia africae ESF-5 7815031 YP_002845037.1 CDS mnhC NC_012633.1 385858 386193 R subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit C complement(385858..386193) Rickettsia africae ESF-5 7815032 YP_002845038.1 CDS virB9-1 NC_012633.1 386272 387024 R VirB9 complement(386272..387024) Rickettsia africae ESF-5 7815033 YP_002845039.1 CDS virB8-1 NC_012633.1 387026 387724 R virulence protein complement(387026..387724) Rickettsia africae ESF-5 7815034 YP_002845040.1 CDS RAF_ORF0360 NC_012633.1 388185 388364 D hypothetical protein 388185..388364 Rickettsia africae ESF-5 7815035 YP_002845041.1 CDS virB8-2 NC_012633.1 388414 389145 D virulence protein 388414..389145 Rickettsia africae ESF-5 7815036 YP_002845042.1 CDS virB9-2 NC_012633.1 389132 389605 D VirB9 389132..389605 Rickettsia africae ESF-5 7815037 YP_002845043.1 CDS virB10 NC_012633.1 389789 391237 D VirB10 389789..391237 Rickettsia africae ESF-5 7815038 YP_002845044.1 CDS virB11 NC_012633.1 391234 392238 D type IV secretion system ATPase VirB11 391234..392238 Rickettsia africae ESF-5 7815039 YP_002845045.1 CDS virD4 NC_012633.1 392393 394168 D type IV secretion system protein VirB8 392393..394168 Rickettsia africae ESF-5 7815040 YP_002845046.1 CDS gppA NC_012633.1 394170 395582 D Guanosine pentaphosphate phosphohydrolase 394170..395582 Rickettsia africae ESF-5 7815041 YP_002845047.1 CDS RAF_ORF0367 NC_012633.1 395796 396197 R hypothetical protein complement(395796..396197) Rickettsia africae ESF-5 7815042 YP_002845048.1 CDS RAF_ORF0368 NC_012633.1 396235 396525 R hypothetical protein complement(396235..396525) Rickettsia africae ESF-5 7815043 YP_002845049.1 CDS RAF_ORF0369 NC_012633.1 396984 397364 R hypothetical protein complement(396984..397364) Rickettsia africae ESF-5 7815044 YP_002845050.1 CDS RAF_ORF0370 NC_012633.1 397587 397871 D Phage portal protein 397587..397871 Rickettsia africae ESF-5 7815045 YP_002845051.1 CDS RAF_ORF0371 NC_012633.1 398147 398272 R hypothetical protein complement(398147..398272) Rickettsia africae ESF-5 7815046 YP_002845052.1 CDS RAF_ORF0372 NC_012633.1 398505 399392 D hypothetical protein 398505..399392 Rickettsia africae ESF-5 7815047 YP_002845053.1 CDS RAF_ORF0373 NC_012633.1 399355 400200 D hypothetical protein 399355..400200 Rickettsia africae ESF-5 7815048 YP_002845054.1 CDS cysQ NC_012633.1 400203 400979 D 3'(2'),5'-bisphosphate nucleotidase 400203..400979 Rickettsia africae ESF-5 7815049 YP_002845055.1 CDS mutS NC_012633.1 401119 403791 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(401119..403791) Rickettsia africae ESF-5 7815050 YP_002845056.1 CDS lacA NC_012633.1 403964 404398 R catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B complement(403964..404398) Rickettsia africae ESF-5 7815051 YP_002845057.1 CDS nlpD1 NC_012633.1 404450 405124 D Membrane-bound metallopeptidase 404450..405124 Rickettsia africae ESF-5 7815052 YP_002845058.1 CDS RAF_ORF0378 NC_012633.1 405125 405817 D Putative metal-dependent hydrolase 405125..405817 Rickettsia africae ESF-5 7815053 YP_002845059.1 CDS thyX NC_012633.1 405908 406792 D flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 405908..406792 Rickettsia africae ESF-5 7815054 YP_002845060.1 CDS tolB NC_012633.1 406867 408201 D forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 406867..408201 Rickettsia africae ESF-5 7815055 YP_002845061.1 CDS rpoH NC_012633.1 408340 409221 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(408340..409221) Rickettsia africae ESF-5 7815056 YP_002845062.1 CDS cox11 NC_012633.1 409310 409876 D involved in the insertion of copper into subunit I of cytochrome C oxidase; cytochrome C oxidase assembly protein 409310..409876 Rickettsia africae ESF-5 7815057 YP_002845063.1 CDS RAF_ORF0383 NC_012633.1 409974 410954 R hypothetical protein complement(409974..410954) Rickettsia africae ESF-5 7815058 YP_002845064.1 CDS mnmA NC_012633.1 411222 412319 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 411222..412319 Rickettsia africae ESF-5 7815059 YP_002845065.1 CDS atrC1 NC_012633.1 412450 413847 D Cationic amino acid transporter-1 412450..413847 Rickettsia africae ESF-5 7815060 YP_002845066.1 CDS hisS NC_012633.1 413997 415241 D catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 413997..415241 Rickettsia africae ESF-5 7815061 YP_002845067.1 CDS RAF_ORF0387 NC_012633.1 415674 415871 D ABC transporter ATP-binding protein 415674..415871 Rickettsia africae ESF-5 7815062 YP_002845068.1 CDS RAF_ORF0388 NC_012633.1 415943 416152 D ABC transporter ATP-binding protein 415943..416152 Rickettsia africae ESF-5 7815063 YP_002845069.1 CDS RAF_ORF0389 NC_012633.1 416552 416956 R hypothetical protein complement(416552..416956) Rickettsia africae ESF-5 7815064 YP_002845070.1 CDS RAF_ORF0390 NC_012633.1 417030 418034 R hypothetical protein complement(417030..418034) Rickettsia africae ESF-5 7815065 YP_002845071.1 CDS RAF_ORF0391 NC_012633.1 418495 418923 R hypothetical protein complement(418495..418923) Rickettsia africae ESF-5 7815066 YP_002845072.1 CDS tolQ NC_012633.1 419425 420150 D TolQ 419425..420150 Rickettsia africae ESF-5 7815067 YP_002845073.1 CDS tolR NC_012633.1 420150 420581 D TolR 420150..420581 Rickettsia africae ESF-5 7815068 YP_002845074.1 CDS RAF_ORF0394 NC_012633.1 420571 421542 D Periplasmic protein TonB, links inner and outer membranes 420571..421542 Rickettsia africae ESF-5 7815069 YP_002845075.1 CDS spoT2 NC_012633.1 422516 423223 D Guanosine polyphosphate pyrophosphohydrolase/synthetase 422516..423223 Rickettsia africae ESF-5 7815070 YP_002845076.1 CDS proP2 NC_012633.1 423174 424490 R Proline/betaine transporter complement(423174..424490) Rickettsia africae ESF-5 7815071 YP_002845077.1 CDS RAF_ORF0397 NC_012633.1 424629 426164 R HlyD family secretion protein complement(424629..426164) Rickettsia africae ESF-5 7815072 YP_002845078.1 CDS aprD NC_012633.1 426349 428103 R Alkaline protease secretion ATP-binding protein AprD complement(426349..428103) Rickettsia africae ESF-5 7815073 YP_002845079.1 CDS asd NC_012633.1 428114 429130 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(428114..429130) Rickettsia africae ESF-5 7815074 YP_002845080.1 CDS pkcI NC_012633.1 429123 429485 R Protein kinase C inhibitor 1 complement(429123..429485) Rickettsia africae ESF-5 7815075 YP_002845081.1 CDS RAF_ORF0401 NC_012633.1 429673 430026 R hypothetical protein complement(429673..430026) Rickettsia africae ESF-5 7815076 YP_002845082.1 CDS hslV NC_012633.1 430290 430838 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 430290..430838 Rickettsia africae ESF-5 7815077 YP_002845083.1 CDS hslU NC_012633.1 430835 432187 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 430835..432187 Rickettsia africae ESF-5 7815078 YP_002845084.1 CDS RAF_ORF0407 NC_012633.1 434337 434915 D hypothetical protein 434337..434915 Rickettsia africae ESF-5 7815080 YP_002845085.1 CDS lpxB NC_012633.1 434925 436265 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 434925..436265 Rickettsia africae ESF-5 7815081 YP_002845086.1 CDS RAF_ORF0409 NC_012633.1 436262 436534 R hypothetical protein complement(436262..436534) Rickettsia africae ESF-5 7815082 YP_002845087.1 CDS RAF_ORF0410 NC_012633.1 436881 437900 D Aminodeoxychorismate lyase 436881..437900 Rickettsia africae ESF-5 7815083 YP_002845088.1 CDS cyaY NC_012633.1 438040 438351 D defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 438040..438351 Rickettsia africae ESF-5 7815084 YP_002845089.1 CDS RAF_ORF0412 NC_012633.1 438489 439058 D hypothetical protein 438489..439058 Rickettsia africae ESF-5 7815085 YP_002845090.1 CDS RAF_ORF0413 NC_012633.1 439826 439960 D hypothetical protein 439826..439960 Rickettsia africae ESF-5 7815086 YP_002845091.1 CDS RAF_ORF0414 NC_012633.1 440123 440674 D hypothetical protein 440123..440674 Rickettsia africae ESF-5 7815087 YP_002845092.1 CDS RAF_ORF0415 NC_012633.1 441169 441453 D hypothetical protein 441169..441453 Rickettsia africae ESF-5 7815088 YP_002845093.1 CDS gltX NC_012633.1 441811 443154 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(441811..443154) Rickettsia africae ESF-5 7815089 YP_002845094.1 CDS topA NC_012633.1 443263 445593 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(443263..445593) Rickettsia africae ESF-5 7815090 YP_002845095.1 CDS tdpX1 NC_012633.1 446994 447602 R Thioredoxin peroxidase 1 complement(446994..447602) Rickettsia africae ESF-5 7815092 YP_002845096.1 CDS hflC1 NC_012633.1 447678 448616 R Membrane protease subunit, stomatin/prohibitin-like protein complement(447678..448616) Rickettsia africae ESF-5 7815093 YP_002845097.1 CDS RAF_ORF0422 NC_012633.1 448981 450549 R Putative membrane-associated metal-dependent hydrolase complement(448981..450549) Rickettsia africae ESF-5 7815094 YP_002845098.1 CDS RAF_ORF0423 NC_012633.1 450585 451049 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 450585..451049 Rickettsia africae ESF-5 7815095 YP_002845099.1 CDS RAF_ORF0424 NC_012633.1 451307 451477 D Plasmid maintenance system antidote protein 451307..451477 Rickettsia africae ESF-5 7815096 YP_002845100.1 CDS RAF_ORF0425 NC_012633.1 451648 452502 D dTDP-4-dehydrorhamnose reductase 451648..452502 Rickettsia africae ESF-5 7815097 YP_002845101.1 CDS capD NC_012633.1 452685 453710 D Putative nucleoside-diphosphate sugar epimerase CapD 452685..453710 Rickettsia africae ESF-5 7815098 YP_002845102.1 CDS rffE NC_012633.1 453703 454836 D UDP-N-acetylglucosamine 2-epimerase 453703..454836 Rickettsia africae ESF-5 7815018 YP_002845103.1 CDS RAF_ORF0428 NC_012633.1 454796 456142 D hypothetical protein 454796..456142 Rickettsia africae ESF-5 7815498 YP_002845104.1 CDS RAF_ORF0429 NC_012633.1 456158 456406 D hypothetical protein 456158..456406 Rickettsia africae ESF-5 7815499 YP_002845105.1 CDS RAF_ORF0430 NC_012633.1 457080 458894 D Glycosyltransferase, two domains 457080..458894 Rickettsia africae ESF-5 7815500 YP_002845106.1 CDS RAF_ORF0431 NC_012633.1 458899 459897 R Efflux transporter, RND family, MFP subunit complement(458899..459897) Rickettsia africae ESF-5 7815501 YP_002845107.1 CDS RAF_ORF0432 NC_012633.1 459984 460778 R hypothetical protein complement(459984..460778) Rickettsia africae ESF-5 7815502 YP_002845108.1 CDS RAF_ORF0433 NC_012633.1 460788 461555 R Putative hydrolase/acyltransferase complement(460788..461555) Rickettsia africae ESF-5 7815503 YP_002845109.1 CDS RAF_ORF0434 NC_012633.1 461588 462760 D Glycosyltransferase 461588..462760 Rickettsia africae ESF-5 7815504 YP_002845110.1 CDS rpsD NC_012633.1 465262 465879 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(465262..465879) Rickettsia africae ESF-5 7815505 YP_002845111.1 CDS cyoB NC_012633.1 466004 466921 D converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 466004..466921 Rickettsia africae ESF-5 7815506 YP_002845112.1 CDS RAF_ORF0437 NC_012633.1 467327 467956 R Putative lyase complement(467327..467956) Rickettsia africae ESF-5 7815507 YP_002845113.1 CDS RAF_ORF0438 NC_012633.1 468436 468795 D hypothetical protein 468436..468795 Rickettsia africae ESF-5 7815508 YP_002845114.1 CDS asmA NC_012633.1 468936 471455 R Outer membrane assembly protein complement(468936..471455) Rickettsia africae ESF-5 7815509 YP_002845115.1 CDS rimM NC_012633.1 471738 472235 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(471738..472235) Rickettsia africae ESF-5 7815510 YP_002845116.1 CDS RAF_ORF0441 NC_012633.1 472298 474928 D hypothetical protein 472298..474928 Rickettsia africae ESF-5 7815511 YP_002845117.1 CDS xseB NC_012633.1 474942 475184 D catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 474942..475184 Rickettsia africae ESF-5 7815512 YP_002845118.1 CDS RAF_ORF0445 NC_012633.1 475880 476605 D hypothetical protein 475880..476605 Rickettsia africae ESF-5 7815514 YP_002845119.1 CDS mpg NC_012633.1 476571 477122 R responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase complement(476571..477122) Rickettsia africae ESF-5 7815515 YP_002845120.1 CDS RAF_ORF0447 NC_012633.1 477416 477664 R hypothetical protein complement(477416..477664) Rickettsia africae ESF-5 7815516 YP_002845121.1 CDS nuoE NC_012633.1 477657 478160 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(477657..478160) Rickettsia africae ESF-5 7815517 YP_002845122.1 CDS nuoD NC_012633.1 478586 479854 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D complement(478586..479854) Rickettsia africae ESF-5 7815518 YP_002845123.1 CDS nuoC NC_012633.1 479860 480588 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C complement(479860..480588) Rickettsia africae ESF-5 7815519 YP_002845124.1 CDS nuoB NC_012633.1 480566 481090 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(480566..481090) Rickettsia africae ESF-5 7815520 YP_002845125.1 CDS nuoA NC_012633.1 481095 481493 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A complement(481095..481493) Rickettsia africae ESF-5 7815521 YP_002845126.1 CDS rfaL NC_012633.1 481624 482859 R Putative lipid A core - O-antigen ligase complement(481624..482859) Rickettsia africae ESF-5 7815522 YP_002845127.1 CDS RAF_ORF0454 NC_012633.1 482860 483333 R hypothetical protein complement(482860..483333) Rickettsia africae ESF-5 7815523 YP_002845128.1 CDS xerD NC_012633.1 485147 486067 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 485147..486067 Rickettsia africae ESF-5 7815526 YP_002845129.1 CDS RAF_ORF0460 NC_012633.1 486151 487170 D hypothetical protein 486151..487170 Rickettsia africae ESF-5 7815527 YP_002845130.1 CDS RAF_ORF0461 NC_012633.1 487264 488445 D hypothetical protein 487264..488445 Rickettsia africae ESF-5 7815528 YP_002845131.1 CDS fabI NC_012633.1 488632 489372 R Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase complement(488632..489372) Rickettsia africae ESF-5 7815529 YP_002845132.1 CDS lnt NC_012633.1 489494 491008 D Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 489494..491008 Rickettsia africae ESF-5 7815530 YP_002845133.1 CDS ampD1 NC_012633.1 491698 492501 D Negative regulator of beta-lactamase expression 491698..492501 Rickettsia africae ESF-5 7815531 YP_002845134.1 CDS RAF_ORF0465 NC_012633.1 492953 493870 D ABC transporter substrate-binding protein 492953..493870 Rickettsia africae ESF-5 7815532 YP_002845135.1 CDS RAF_ORF0466 NC_012633.1 493797 494714 D ABC transporter permease 493797..494714 Rickettsia africae ESF-5 7815533 YP_002845136.1 CDS RAF_ORF0467 NC_012633.1 494711 495433 D ABC transporter ATP-binding protein 494711..495433 Rickettsia africae ESF-5 7815534 YP_002845137.1 CDS RAF_ORF0468 NC_012633.1 495513 495896 R hypothetical protein complement(495513..495896) Rickettsia africae ESF-5 7815535 YP_002845138.1 CDS dsbB NC_012633.1 497244 497762 R Disulfide bond formation protein DsbB complement(497244..497762) Rickettsia africae ESF-5 7815537 YP_002845139.1 CDS lysK NC_012633.1 497941 499509 D class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine; lysyl-tRNA synthetase 497941..499509 Rickettsia africae ESF-5 7815538 YP_002845140.1 CDS RAF_ORF0473 NC_012633.1 499643 500575 D Putative permease 499643..500575 Rickettsia africae ESF-5 7815539 YP_002845141.1 CDS tme NC_012633.1 500715 503018 D NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 500715..503018 Rickettsia africae ESF-5 7815540 YP_002845142.1 CDS RAF_ORF0475 NC_012633.1 504128 504541 R hypothetical protein complement(504128..504541) Rickettsia africae ESF-5 7815541 YP_002845143.1 CDS RAF_ORF0476 NC_012633.1 504507 504755 R Transcriptional regulator, AbrB family complement(504507..504755) Rickettsia africae ESF-5 7815542 YP_002845144.1 CDS proP3 NC_012633.1 504992 506209 D Proline/betaine transporter 504992..506209 Rickettsia africae ESF-5 7815543 YP_002845145.1 CDS mdh NC_012633.1 509630 510574 R Catalyzes the reversible oxidation of malate to oxaloacetate; malate dehydrogenase complement(509630..510574) Rickettsia africae ESF-5 7815545 YP_002845146.1 CDS RAF_ORF0482 NC_012633.1 510690 510941 D Ankyrin repeat protein 510690..510941 Rickettsia africae ESF-5 7815546 YP_002845147.1 CDS tlc2 NC_012633.1 512072 513595 R ATP/ADP translocase complement(512072..513595) Rickettsia africae ESF-5 7815547 YP_002845148.1 CDS pyrG NC_012633.1 513804 515417 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(513804..515417) Rickettsia africae ESF-5 7815548 YP_002845149.1 CDS kdsB NC_012633.1 515420 516160 R CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase complement(515420..516160) Rickettsia africae ESF-5 7815549 YP_002845150.1 CDS RAF_ORF0486 NC_012633.1 516711 516839 D hypothetical protein 516711..516839 Rickettsia africae ESF-5 7815552 YP_002845151.1 CDS mutT NC_012633.1 516932 517222 R ADP-ribose pyrophosphatase MutT complement(516932..517222) Rickettsia africae ESF-5 7815553 YP_002845152.1 CDS RAF_ORF0488 NC_012633.1 517389 518912 D hypothetical protein 517389..518912 Rickettsia africae ESF-5 7815554 YP_002845153.1 CDS folE NC_012633.1 518905 519474 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 518905..519474 Rickettsia africae ESF-5 7815555 YP_002845154.1 CDS proS NC_012633.1 519639 520919 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 519639..520919 Rickettsia africae ESF-5 7815556 YP_002845155.1 CDS RAF_ORF0491 NC_012633.1 521132 522100 D Cell filamentation protein Fic 521132..522100 Rickettsia africae ESF-5 7815557 YP_002845156.1 CDS RAF_ORF0492 NC_012633.1 522291 522497 D hypothetical protein 522291..522497 Rickettsia africae ESF-5 7815558 YP_002845157.1 CDS ruvA NC_012633.1 522502 523113 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 522502..523113 Rickettsia africae ESF-5 7815559 YP_002845158.1 CDS RAF_ORF0494 NC_012633.1 523748 524035 D hypothetical protein 523748..524035 Rickettsia africae ESF-5 7815560 YP_002845159.1 CDS ruvB NC_012633.1 524111 525139 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 524111..525139 Rickettsia africae ESF-5 7815561 YP_002845160.1 CDS msbA1 NC_012633.1 525132 526895 D Multidrug resistance protein 525132..526895 Rickettsia africae ESF-5 7815562 YP_002845161.1 CDS ampG4 NC_012633.1 527089 528333 D AmpG protein 527089..528333 Rickettsia africae ESF-5 7815563 YP_002845162.1 CDS dacF NC_012633.1 528510 529430 D Penicillin-binding protein dacF precursor 528510..529430 Rickettsia africae ESF-5 7815564 YP_002845163.1 CDS rlpA NC_012633.1 529600 530562 R Rare lipoprotein A precursor complement(529600..530562) Rickettsia africae ESF-5 7815565 YP_002845164.1 CDS osmY NC_012633.1 530540 531157 R Putative periplasmic or secreted lipoprotein complement(530540..531157) Rickettsia africae ESF-5 7815566 YP_002845165.1 CDS ispZ NC_012633.1 531390 531932 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(531390..531932) Rickettsia africae ESF-5 7815567 YP_002845166.1 CDS RAF_ORF0502 NC_012633.1 531962 532810 R FTR1 family protein complement(531962..532810) Rickettsia africae ESF-5 7815568 YP_002845167.1 CDS RAF_ORF0503 NC_012633.1 532820 533200 R hypothetical protein complement(532820..533200) Rickettsia africae ESF-5 7815569 YP_002845168.1 CDS RAF_ORF0504 NC_012633.1 533391 534386 R hypothetical protein complement(533391..534386) Rickettsia africae ESF-5 7815570 YP_002845169.1 CDS RAF_ORF0505 NC_012633.1 534531 535157 D Protocatechuate-3,4-dioxygenase, beta subunit 534531..535157 Rickettsia africae ESF-5 7815571 YP_002845170.1 CDS tlpA NC_012633.1 535365 536009 D Thiol:disulfide interchange protein tlpA 535365..536009 Rickettsia africae ESF-5 7815572 YP_002845171.1 CDS sppA1 NC_012633.1 536174 537088 D signal peptide peptidase SppA 536174..537088 Rickettsia africae ESF-5 7815573 YP_002845172.1 CDS dut NC_012633.1 537090 537536 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 537090..537536 Rickettsia africae ESF-5 7815574 YP_002845173.1 CDS mltE1 NC_012633.1 537754 539715 D lytic murein transglycosylase 537754..539715 Rickettsia africae ESF-5 7815575 YP_002845174.1 CDS RAF_ORF0510 NC_012633.1 539802 540761 D hypothetical protein 539802..540761 Rickettsia africae ESF-5 7815576 YP_002845175.1 CDS mccF NC_012633.1 540955 541902 D Microcin C7 self-immunity protein 540955..541902 Rickettsia africae ESF-5 7815577 YP_002845176.1 CDS RAF_ORF0512 NC_012633.1 542081 544597 R recombinase B complement(542081..544597) Rickettsia africae ESF-5 7816011 YP_002845177.1 CDS RAF_ORF0513 NC_012633.1 544748 545149 D hypothetical protein 544748..545149 Rickettsia africae ESF-5 7814937 YP_002845178.1 CDS RAF_ORF0514 NC_012633.1 545153 545881 R Putative glutamine amidotransferase complement(545153..545881) Rickettsia africae ESF-5 7814938 YP_002845179.1 CDS coxA NC_012633.1 546079 547677 R cytochrome c oxidase polypeptide I complement(546079..547677) Rickettsia africae ESF-5 7814939 YP_002845180.1 CDS RAF_ORF0516 NC_012633.1 547683 548066 R Acetyltransferase complement(547683..548066) Rickettsia africae ESF-5 7814940 YP_002845181.1 CDS coxB NC_012633.1 548259 549206 R cytochrome c oxidase polypeptide II complement(548259..549206) Rickettsia africae ESF-5 7814941 YP_002845182.1 CDS tagD NC_012633.1 549390 549809 R Glycerol-3-phosphate cytidyltransferase TagD complement(549390..549809) Rickettsia africae ESF-5 7814942 YP_002845183.1 CDS nlpD2 NC_012633.1 550048 551412 D Membrane-bound metallopeptidase 550048..551412 Rickettsia africae ESF-5 7814943 YP_002845184.1 CDS lspA NC_012633.1 551606 552211 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 551606..552211 Rickettsia africae ESF-5 7814944 YP_002845185.1 CDS RAF_ORF0521 NC_012633.1 552364 552612 D hypothetical protein 552364..552612 Rickettsia africae ESF-5 7814945 YP_002845186.1 CDS murD NC_012633.1 552783 554285 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 552783..554285 Rickettsia africae ESF-5 7814946 YP_002845187.1 CDS ftsW NC_012633.1 554417 555550 D Cell division protein ftsW 554417..555550 Rickettsia africae ESF-5 7814947 YP_002845188.1 CDS murG NC_012633.1 555547 556677 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase 555547..556677 Rickettsia africae ESF-5 7814948 YP_002845189.1 CDS RAF_ORF0525 NC_012633.1 557073 557723 D hypothetical protein 557073..557723 Rickettsia africae ESF-5 7814949 YP_002845190.1 CDS RAF_ORF0536 NC_012633.1 564356 565372 R Glycosyltransferase complement(564356..565372) Rickettsia africae ESF-5 7814953 YP_002845191.1 CDS RAF_ORF0537 NC_012633.1 565372 565656 R hypothetical protein complement(565372..565656) Rickettsia africae ESF-5 7814954 YP_002845192.1 CDS RAF_ORF0538 NC_012633.1 565696 565929 R hypothetical protein complement(565696..565929) Rickettsia africae ESF-5 7814955 YP_002845193.1 CDS RAF_ORF0539 NC_012633.1 566062 566256 R hypothetical protein complement(566062..566256) Rickettsia africae ESF-5 7814956 YP_002845194.1 CDS dapF NC_012633.1 566345 567157 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 566345..567157 Rickettsia africae ESF-5 7814957 YP_002845195.1 CDS RAF_ORF0541 NC_012633.1 567132 568397 D MiaB-like tRNA modifying enzyme 567132..568397 Rickettsia africae ESF-5 7814958 YP_002845196.1 CDS pheS NC_012633.1 568638 569687 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 568638..569687 Rickettsia africae ESF-5 7814959 YP_002845197.1 CDS pheT NC_012633.1 569684 572140 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 569684..572140 Rickettsia africae ESF-5 7814960 YP_002845198.1 CDS dnaN NC_012633.1 572145 573284 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 572145..573284 Rickettsia africae ESF-5 7814961 YP_002845199.1 CDS RAF_ORF0545 NC_012633.1 573645 574148 D hypothetical protein 573645..574148 Rickettsia africae ESF-5 7814962 YP_002845200.1 CDS leuS NC_012633.1 574277 576784 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 574277..576784 Rickettsia africae ESF-5 7814963 YP_002845201.1 CDS rnd2 NC_012633.1 577835 578446 R Ribonuclease D complement(577835..578446) Rickettsia africae ESF-5 7814964 YP_002845202.1 CDS RAF_ORF0548 NC_012633.1 578597 578902 R septum formation initiator complement(578597..578902) Rickettsia africae ESF-5 7814965 YP_002845203.1 CDS cdsA NC_012633.1 578899 579591 R phosphatidate cytidylyltransferase complement(578899..579591) Rickettsia africae ESF-5 7814966 YP_002845204.1 CDS uppS NC_012633.1 579551 580258 R UDP pyrophosphate synthetase complement(579551..580258) Rickettsia africae ESF-5 7814967 YP_002845205.1 CDS envZ NC_012633.1 580404 581843 R Osmolarity sensor protein EnvZ complement(580404..581843) Rickettsia africae ESF-5 7814968 YP_002845206.1 CDS ompR NC_012633.1 581818 582498 R PetR complement(581818..582498) Rickettsia africae ESF-5 7814969 YP_002845207.1 CDS ilvE NC_012633.1 582714 583586 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 582714..583586 Rickettsia africae ESF-5 7814970 YP_002845208.1 CDS dapA NC_012633.1 583772 584656 D catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 583772..584656 Rickettsia africae ESF-5 7814971 YP_002845209.1 CDS smpB NC_012633.1 584653 585111 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 584653..585111 Rickettsia africae ESF-5 7814972 YP_002845210.1 CDS dsbA NC_012633.1 585244 586035 D Thiol:disulfide interchange protein dsbA 585244..586035 Rickettsia africae ESF-5 7814973 YP_002845211.1 CDS sucD NC_012633.1 586269 587144 R Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha complement(586269..587144) Rickettsia africae ESF-5 7814974 YP_002845212.1 CDS sucC NC_012633.1 587320 588480 R catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta complement(587320..588480) Rickettsia africae ESF-5 7814975 YP_002845213.1 CDS RAF_ORF0559 NC_012633.1 588513 588932 R Putative nucleic-acid-binding protein, containing PIN domain complement(588513..588932) Rickettsia africae ESF-5 7814976 YP_002845214.1 CDS RAF_ORF0560 NC_012633.1 588889 589140 R Transcriptional regulator, AbrB family complement(588889..589140) Rickettsia africae ESF-5 7814977 YP_002845215.1 CDS RAF_ORF0563 NC_012633.1 589922 591952 R Acylamino-acid-releasing enzyme complement(589922..591952) Rickettsia africae ESF-5 7814979 YP_002845216.1 CDS RAF_ORF0564 NC_012633.1 592040 592675 R hypothetical protein complement(592040..592675) Rickettsia africae ESF-5 7814980 YP_002845217.1 CDS RAF_ORF0565 NC_012633.1 593134 593682 R hypothetical protein complement(593134..593682) Rickettsia africae ESF-5 7814981 YP_002845218.1 CDS RAF_ORF0566 NC_012633.1 593701 593928 R hypothetical protein complement(593701..593928) Rickettsia africae ESF-5 7814982 YP_002845219.1 CDS rbfA NC_012633.1 594105 594467 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(594105..594467) Rickettsia africae ESF-5 7814983 YP_002845220.1 CDS RAF_ORF0568 NC_012633.1 594464 594898 R hypothetical protein complement(594464..594898) Rickettsia africae ESF-5 7814984 YP_002845221.1 CDS RAF_ORF0569 NC_012633.1 595041 595562 D RDD family protein 595041..595562 Rickettsia africae ESF-5 7814985 YP_002845222.1 CDS recR NC_012633.1 595710 596315 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 595710..596315 Rickettsia africae ESF-5 7814986 YP_002845223.1 CDS ppnK NC_012633.1 596913 597680 R catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase complement(596913..597680) Rickettsia africae ESF-5 7814987 YP_002845224.1 CDS RAF_ORF0572 NC_012633.1 597764 599446 D Putative hydrolase of the metallo-beta-lactamase superfamily 597764..599446 Rickettsia africae ESF-5 7814988 YP_002845225.1 CDS gpsA NC_012633.1 599586 600563 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 599586..600563 Rickettsia africae ESF-5 7814989 YP_002845226.1 CDS RAF_ORF0574 NC_012633.1 600788 601717 D Putative permease 600788..601717 Rickettsia africae ESF-5 7814990 YP_002845227.1 CDS RAF_ORF0575 NC_012633.1 601786 602658 D Putative hydrolase/acyltransferase 601786..602658 Rickettsia africae ESF-5 7814991 YP_002845228.1 CDS trxB1 NC_012633.1 602860 603792 D Thioredoxin reductase 602860..603792 Rickettsia africae ESF-5 7814992 YP_002845229.1 CDS RAF_ORF0577 NC_012633.1 604012 604308 D hypothetical protein 604012..604308 Rickettsia africae ESF-5 7814993 YP_002845230.1 CDS gabD NC_012633.1 604963 606390 D succinate semialdehyde dehydrogenase 604963..606390 Rickettsia africae ESF-5 7814994 YP_002845231.1 CDS lgtD NC_012633.1 606886 607731 D Glycosyl transferase 606886..607731 Rickettsia africae ESF-5 7814995 YP_002845232.1 CDS uvrD NC_012633.1 607809 609770 D DNA helicase II 607809..609770 Rickettsia africae ESF-5 7814996 YP_002845233.1 CDS RAF_ORF0581 NC_012633.1 609836 610345 D hypothetical protein 609836..610345 Rickettsia africae ESF-5 7814997 YP_002845234.1 CDS RAF_ORF0582 NC_012633.1 610795 612147 D hypothetical protein 610795..612147 Rickettsia africae ESF-5 7814998 YP_002845235.1 CDS tdcB NC_012633.1 612324 613355 R catalyzes the formation of 2-oxobutanoate from L-threonine; threonine dehydratase complement(612324..613355) Rickettsia africae ESF-5 7814999 YP_002845236.1 CDS lon1 NC_012633.1 613441 615777 D ATP-dependent protease La 613441..615777 Rickettsia africae ESF-5 7815000 YP_002845237.1 CDS sca3 NC_012633.1 617283 617813 D Cell surface antigen Sca3 617283..617813 Rickettsia africae ESF-5 7815001 YP_002845238.1 CDS RAF_ORF0586 NC_012633.1 618310 618660 R hypothetical protein complement(618310..618660) Rickettsia africae ESF-5 7815002 YP_002845239.1 CDS RAF_ORF0587 NC_012633.1 619326 619634 D hypothetical protein 619326..619634 Rickettsia africae ESF-5 7815004 YP_002845240.1 CDS yhbH NC_012633.1 619751 620329 D Putative sigma(54) modulation protein 619751..620329 Rickettsia africae ESF-5 7815005 YP_002845241.1 CDS paaY NC_012633.1 620329 620844 D Carbonic anhydrases/acetyltransferase, isoleucine patch superfamily protein 620329..620844 Rickettsia africae ESF-5 7815006 YP_002845242.1 CDS folD NC_012633.1 620875 621741 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(620875..621741) Rickettsia africae ESF-5 7815007 YP_002845243.1 CDS trxB2 NC_012633.1 621878 622900 R Thioredoxin reductase complement(621878..622900) Rickettsia africae ESF-5 7815008 YP_002845244.1 CDS RAF_ORF0595 NC_012633.1 625277 625603 D hypothetical protein 625277..625603 Rickettsia africae ESF-5 7815010 YP_002845245.1 CDS nrdA NC_012633.1 626965 628788 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 626965..628788 Rickettsia africae ESF-5 7815011 YP_002845246.1 CDS RAF_ORF0597 NC_012633.1 628862 629257 D hypothetical protein 628862..629257 Rickettsia africae ESF-5 7815012 YP_002845247.1 CDS nrdF NC_012633.1 629649 630635 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 629649..630635 Rickettsia africae ESF-5 7815013 YP_002845248.1 CDS RAF_ORF0599 NC_012633.1 630778 633660 D hypothetical protein 630778..633660 Rickettsia africae ESF-5 7815014 YP_002845249.1 CDS miaA NC_012633.1 635743 636777 R IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase complement(635743..636777) Rickettsia africae ESF-5 7815016 YP_002845250.1 CDS exoC NC_012633.1 637304 638692 R phosphomannomutase complement(637304..638692) Rickettsia africae ESF-5 7815017 YP_002845251.1 CDS abcT2 NC_012633.1 638863 639585 R ABC transporter ATP-binding protein complement(638863..639585) Rickettsia africae ESF-5 7815099 YP_002845252.1 CDS RAF_ORF0605 NC_012633.1 639773 640357 R hypothetical protein complement(639773..640357) Rickettsia africae ESF-5 7815100 YP_002845253.1 CDS RAF_ORF0606 NC_012633.1 640326 640922 R hypothetical protein complement(640326..640922) Rickettsia africae ESF-5 7815101 YP_002845254.1 CDS kpsF NC_012633.1 640928 641887 R KpsF complement(640928..641887) Rickettsia africae ESF-5 7815102 YP_002845255.1 CDS pnp NC_012633.1 642087 644333 R polynucleotide phosphorylase/polyadenylase complement(642087..644333) Rickettsia africae ESF-5 7815103 YP_002845256.1 CDS rpsO NC_012633.1 644481 644756 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(644481..644756) Rickettsia africae ESF-5 7815104 YP_002845257.1 CDS truB NC_012633.1 644792 645829 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; proteins in this cluster have Rickettsial repeat elements (RPE) inserts; tRNA pseudouridine synthase B complement(644792..645829) Rickettsia africae ESF-5 7815105 YP_002845258.1 CDS tlc4 NC_012633.1 645916 647451 D ATP/ADP translocase 645916..647451 Rickettsia africae ESF-5 7815106 YP_002845259.1 CDS sca4 NC_012633.1 647729 650815 D Cell surface antigen Sca4 647729..650815 Rickettsia africae ESF-5 7815107 YP_002845260.1 CDS hipB NC_012633.1 650934 651311 R Putative transcriptional regulator complement(650934..651311) Rickettsia africae ESF-5 7815108 YP_002845261.1 CDS rbn NC_012633.1 651835 652662 D Putative ribonuclease BN 651835..652662 Rickettsia africae ESF-5 7815109 YP_002845262.1 CDS glnA NC_012633.1 652811 653644 R glutamine synthetase complement(652811..653644) Rickettsia africae ESF-5 7815110 YP_002845263.1 CDS RAF_ORF0616 NC_012633.1 653643 654365 D hypothetical protein 653643..654365 Rickettsia africae ESF-5 7815111 YP_002845264.1 CDS def2 NC_012633.1 654658 655209 D Polypeptide deformylase 654658..655209 Rickettsia africae ESF-5 7815112 YP_002845265.1 CDS RAF_ORF0618 NC_012633.1 655420 655617 D Antitoxin of toxin-antitoxin (TA) system Phd 655420..655617 Rickettsia africae ESF-5 7815113 YP_002845266.1 CDS RAF_ORF0619 NC_012633.1 655679 656083 D Toxin of toxin-antitoxin (TA) system, containing PIN domain for nucleic acid binding 655679..656083 Rickettsia africae ESF-5 7815114 YP_002845267.1 CDS addA NC_012633.1 656084 656779 R hypothetical protein complement(656084..656779) Rickettsia africae ESF-5 7815115 YP_002845268.1 CDS RAF_ORF0621 NC_012633.1 657015 658823 R hypothetical protein complement(657015..658823) Rickettsia africae ESF-5 7815116 YP_002845269.1 CDS ppdK NC_012633.1 659077 661713 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase complement(659077..661713) Rickettsia africae ESF-5 7815117 YP_002845270.1 CDS RAF_ORF0623 NC_012633.1 662644 663312 D glutathione S-transferase 662644..663312 Rickettsia africae ESF-5 7815119 YP_002845271.1 CDS bpl1 NC_012633.1 663424 664176 R biotin--protein ligase complement(663424..664176) Rickettsia africae ESF-5 7815120 YP_002845272.1 CDS bioY2 NC_012633.1 664252 664794 D BioY family protein 664252..664794 Rickettsia africae ESF-5 7815121 YP_002845273.1 CDS folC NC_012633.1 664996 666276 D Folylpolyglutamate synthase 664996..666276 Rickettsia africae ESF-5 7815122 YP_002845274.1 CDS sodB NC_012633.1 666447 667076 D Superoxide dismutase 666447..667076 Rickettsia africae ESF-5 7815123 YP_002845275.1 CDS birA NC_012633.1 668993 669805 D Biotin-(acetyl-CoA carboxylase) ligase 668993..669805 Rickettsia africae ESF-5 7815125 YP_002845276.1 CDS RAF_ORF0633 NC_012633.1 670242 670754 D hypothetical protein 670242..670754 Rickettsia africae ESF-5 7815126 YP_002845277.1 CDS RAF_ORF0634 NC_012633.1 670751 671035 D hypothetical protein 670751..671035 Rickettsia africae ESF-5 7815127 YP_002845278.1 CDS RAF_ORF0635 NC_012633.1 671050 671220 D hypothetical protein 671050..671220 Rickettsia africae ESF-5 7815128 YP_002845279.1 CDS RAF_ORF0636 NC_012633.1 671224 671397 D hypothetical protein 671224..671397 Rickettsia africae ESF-5 7815129 YP_002845280.1 CDS RAF_ORF0637 NC_012633.1 671384 671713 D hypothetical protein 671384..671713 Rickettsia africae ESF-5 7815130 YP_002845281.1 CDS infC NC_012633.1 671864 672337 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 671864..672337 Rickettsia africae ESF-5 7815131 YP_002845282.1 CDS pdhC NC_012633.1 672472 673710 D branched-chain alpha-keto acid dehydrogenase subunit E2 672472..673710 Rickettsia africae ESF-5 7815132 YP_002845283.1 CDS prfA NC_012633.1 673843 674910 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 673843..674910 Rickettsia africae ESF-5 7815133 YP_002845284.1 CDS RAF_ORF0641 NC_012633.1 675047 675250 R hypothetical protein complement(675047..675250) Rickettsia africae ESF-5 7815134 YP_002845285.1 CDS RAF_ORF0642 NC_012633.1 675240 675464 R hypothetical protein complement(675240..675464) Rickettsia africae ESF-5 7815135 YP_002845286.1 CDS recJ NC_012633.1 676966 678729 D ssDNA-specific exonuclease RecJ 676966..678729 Rickettsia africae ESF-5 7815136 YP_002845287.1 CDS RAF_ORF0644 NC_012633.1 678773 680095 D Putative methyltransferase 678773..680095 Rickettsia africae ESF-5 7815137 YP_002845288.1 CDS rho NC_012633.1 680480 681856 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 680480..681856 Rickettsia africae ESF-5 7815138 YP_002845289.1 CDS sppA2 NC_012633.1 681981 682895 D signal peptide peptidase SppA 681981..682895 Rickettsia africae ESF-5 7815139 YP_002845290.1 CDS himD NC_012633.1 682898 683140 D Integration host factor beta-subunit 682898..683140 Rickettsia africae ESF-5 7815140 YP_002845291.1 CDS RAF_ORF0648 NC_012633.1 683905 684651 D hypothetical protein 683905..684651 Rickettsia africae ESF-5 7815141 YP_002845292.1 CDS RAF_ORF0649 NC_012633.1 684989 685444 D hypothetical protein 684989..685444 Rickettsia africae ESF-5 7815142 YP_002845293.1 CDS traD_F NC_012633.1 685753 686274 D Putative conjugative transfer protein TraD 685753..686274 Rickettsia africae ESF-5 7815143 YP_002845294.1 CDS RAF_ORF0651 NC_012633.1 686516 686860 R Transposase and inactivated derivative complement(686516..686860) Rickettsia africae ESF-5 7815144 YP_002845295.1 CDS spoT15 NC_012633.1 686799 687311 R Guanosine polyphosphate pyrophosphohydrolase/synthetase complement(686799..687311) Rickettsia africae ESF-5 7815145 YP_002845296.1 CDS dam2 NC_012633.1 692424 693236 D Site-specific DNA adenine methylase 692424..693236 Rickettsia africae ESF-5 7815149 YP_002845297.1 CDS RAF_ORF0660 NC_012633.1 693238 694944 R hypothetical protein complement(693238..694944) Rickettsia africae ESF-5 7815150 YP_002845298.1 CDS RAF_ORF0661 NC_012633.1 695380 695556 D hypothetical protein 695380..695556 Rickettsia africae ESF-5 7815152 YP_002845299.1 CDS cmk NC_012633.1 695780 696439 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 695780..696439 Rickettsia africae ESF-5 7815153 YP_002845300.1 CDS rpsA NC_012633.1 696695 698401 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 696695..698401 Rickettsia africae ESF-5 7815154 YP_002845301.1 CDS clpP NC_012633.1 698516 699166 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 698516..699166 Rickettsia africae ESF-5 7815155 YP_002845302.1 CDS fni NC_012633.1 700101 701129 D catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 700101..701129 Rickettsia africae ESF-5 7815157 YP_002845303.1 CDS RAF_ORF0666 NC_012633.1 701219 701440 R Putative acetyltransferase complement(701219..701440) Rickettsia africae ESF-5 7815158 YP_002845304.1 CDS RAF_ORF0667 NC_012633.1 701474 701689 R hypothetical protein complement(701474..701689) Rickettsia africae ESF-5 7815159 YP_002845305.1 CDS RAF_ORF0668 NC_012633.1 701686 702135 R Acetyltransferase GNAT family protein complement(701686..702135) Rickettsia africae ESF-5 7815160 YP_002845306.1 CDS RAF_ORF0669 NC_012633.1 702330 702665 R hypothetical protein complement(702330..702665) Rickettsia africae ESF-5 7815161 YP_002845307.1 CDS RAF_ORF0670 NC_012633.1 703348 703515 D hypothetical protein 703348..703515 Rickettsia africae ESF-5 7815162 YP_002845308.1 CDS RAF_ORF0671 NC_012633.1 703808 704680 D hypothetical protein 703808..704680 Rickettsia africae ESF-5 7815163 YP_002845309.1 CDS iscR NC_012633.1 705927 706346 D Iron-sulfur cluster assembly transcription factor IscR 705927..706346 Rickettsia africae ESF-5 7815165 YP_002845310.1 CDS spl1 NC_012633.1 706343 707461 D NifS-like protein 706343..707461 Rickettsia africae ESF-5 7815166 YP_002845311.1 CDS iscS NC_012633.1 707564 708796 D catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 707564..708796 Rickettsia africae ESF-5 7815167 YP_002845312.1 CDS iscU NC_012633.1 708948 709343 D scaffold protein 708948..709343 Rickettsia africae ESF-5 7815168 YP_002845313.1 CDS iscA2 NC_012633.1 709347 709679 D Iron-sulfur cluster assembly accessory protein 709347..709679 Rickettsia africae ESF-5 7815169 YP_002845314.1 CDS RAF_ORF0679 NC_012633.1 710201 710380 R lysozyme complement(710201..710380) Rickettsia africae ESF-5 7815170 YP_002845315.1 CDS potE NC_012633.1 710528 711811 D Putrescine-ornithine antiporter 710528..711811 Rickettsia africae ESF-5 7815171 YP_002845316.1 CDS pepP NC_012633.1 711953 713791 D Aminopeptidase P 711953..713791 Rickettsia africae ESF-5 7815172 YP_002845317.1 CDS ispB NC_012633.1 714090 715205 R Octaprenyl-diphosphate synthase complement(714090..715205) Rickettsia africae ESF-5 7815175 YP_002845318.1 CDS RAF_ORF0683 NC_012633.1 715192 716850 R hypothetical protein complement(715192..716850) Rickettsia africae ESF-5 7815659 YP_002845319.1 CDS tlc3 NC_012633.1 717044 718549 R ATP/ADP translocase complement(717044..718549) Rickettsia africae ESF-5 7815660 YP_002845320.1 CDS RAF_ORF0687 NC_012633.1 719104 719241 D hypothetical protein 719104..719241 Rickettsia africae ESF-5 7815662 YP_002845321.1 CDS ampG1 NC_012633.1 719584 720837 D AmpG protein 719584..720837 Rickettsia africae ESF-5 7815663 YP_002845322.1 CDS lysE NC_012633.1 721432 722073 D Lysine efflux permease 721432..722073 Rickettsia africae ESF-5 7815664 YP_002845323.1 CDS RAF_ORF0690 NC_012633.1 722021 722725 D hypothetical protein 722021..722725 Rickettsia africae ESF-5 7815665 YP_002845324.1 CDS RAF_ORF0691 NC_012633.1 722709 723464 D hypothetical protein 722709..723464 Rickettsia africae ESF-5 7815666 YP_002845325.1 CDS RAF_ORF0692 NC_012633.1 723457 724461 D HemY-like protein 723457..724461 Rickettsia africae ESF-5 7815667 YP_002845326.1 CDS RAF_ORF0693 NC_012633.1 724680 725399 R Putative hydrolase of the alpha/beta superfamily complement(724680..725399) Rickettsia africae ESF-5 7815668 YP_002845327.1 CDS relB2 NC_012633.1 725630 725767 D DNA-damage-inducible protein J 725630..725767 Rickettsia africae ESF-5 7815669 YP_002845328.1 CDS RAF_ORF0695 NC_012633.1 726118 726570 R AtsE-like protein complement(726118..726570) Rickettsia africae ESF-5 7815670 YP_002845329.1 CDS plsC NC_012633.1 726623 727348 R 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(726623..727348) Rickettsia africae ESF-5 7815671 YP_002845330.1 CDS trpS NC_012633.1 727426 728418 D catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 727426..728418 Rickettsia africae ESF-5 7815672 YP_002845331.1 CDS RAF_ORF0698 NC_012633.1 729338 729538 R AAA ATPase complement(729338..729538) Rickettsia africae ESF-5 7815674 YP_002845332.1 CDS hemC NC_012633.1 730349 731404 R transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase complement(730349..731404) Rickettsia africae ESF-5 7815675 YP_002845333.1 CDS mccF2 NC_012633.1 731401 732390 R Microcin C7 resistance protein complement(731401..732390) Rickettsia africae ESF-5 7815676 YP_002845334.1 CDS putP NC_012633.1 733050 734885 R Na+/proline symporter and signal transduction histidine kinase complement(733050..734885) Rickettsia africae ESF-5 7815677 YP_002845335.1 CDS RAF_ORF0702 NC_012633.1 735584 736099 R Ankyrin repeat protein complement(735584..736099) Rickettsia africae ESF-5 7815678 YP_002845336.1 CDS RAF_ORF0703 NC_012633.1 736117 736455 R hypothetical protein complement(736117..736455) Rickettsia africae ESF-5 7815679 YP_002845337.1 CDS RAF_ORF0704 NC_012633.1 736776 737783 R GcvT-like putative aminomethyltransferase complement(736776..737783) Rickettsia africae ESF-5 7815680 YP_002845338.1 CDS RAF_ORF0705 NC_012633.1 737857 738687 D hypothetical protein 737857..738687 Rickettsia africae ESF-5 7815681 YP_002845339.1 CDS rnd NC_012633.1 738697 739542 D Ribonuclease D 738697..739542 Rickettsia africae ESF-5 7815682 YP_002845340.1 CDS RAF_ORF0707 NC_012633.1 739918 740460 R 5-formyltetrahydrofolate cyclo-ligase complement(739918..740460) Rickettsia africae ESF-5 7815683 YP_002845341.1 CDS lpdA2 NC_012633.1 740729 742108 R Catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase complement(740729..742108) Rickettsia africae ESF-5 7815684 YP_002845342.1 CDS RAF_ORF0709 NC_012633.1 742261 742941 R hypothetical protein complement(742261..742941) Rickettsia africae ESF-5 7815685 YP_002845343.1 CDS RAF_ORF0710 NC_012633.1 743156 743467 R hypothetical protein complement(743156..743467) Rickettsia africae ESF-5 7815686 YP_002845344.1 CDS dam1 NC_012633.1 743559 744107 R Site-specific DNA methylase complement(743559..744107) Rickettsia africae ESF-5 7815687 YP_002845345.1 CDS RAF_ORF0712 NC_012633.1 744570 745271 R Transposase and inactivated derivative complement(744570..745271) Rickettsia africae ESF-5 7815688 YP_002845346.1 CDS RAF_ORF0713 NC_012633.1 745578 746063 R hypothetical protein complement(745578..746063) Rickettsia africae ESF-5 7815689 YP_002845347.1 CDS mltE2 NC_012633.1 746068 746910 R lytic murein transglycosylase complement(746068..746910) Rickettsia africae ESF-5 7815690 YP_002845348.1 CDS RAF_ORF0715 NC_012633.1 747205 747465 R hypothetical protein complement(747205..747465) Rickettsia africae ESF-5 7815691 YP_002845349.1 CDS rpmJ NC_012633.1 748337 748462 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 748337..748462 Rickettsia africae ESF-5 7815692 YP_002845350.1 CDS RAF_ORF0717 NC_012633.1 748671 749432 D hypothetical protein 748671..749432 Rickettsia africae ESF-5 7815693 YP_002845351.1 CDS glmU NC_012633.1 749429 750175 D UDP-N-acetylglucosamine pyrophosphorylase 749429..750175 Rickettsia africae ESF-5 7815694 YP_002845352.1 CDS RAF_ORF0719 NC_012633.1 750657 750881 R hypothetical protein complement(750657..750881) Rickettsia africae ESF-5 7815696 YP_002845353.1 CDS RAF_ORF0720 NC_012633.1 752722 753039 R hypothetical protein complement(752722..753039) Rickettsia africae ESF-5 7815697 YP_002845354.1 CDS mazG NC_012633.1 753026 753388 R MazG-like protein complement(753026..753388) Rickettsia africae ESF-5 7815698 YP_002845355.1 CDS RAF_ORF0722 NC_012633.1 753469 753786 R hypothetical protein complement(753469..753786) Rickettsia africae ESF-5 7815699 YP_002845356.1 CDS RAF_ORF0723 NC_012633.1 754324 754485 D hypothetical protein 754324..754485 Rickettsia africae ESF-5 7815700 YP_002845357.1 CDS RAF_ORF0724 NC_012633.1 755189 755761 R hypothetical protein complement(755189..755761) Rickettsia africae ESF-5 7815701 YP_002845358.1 CDS RAF_ORF0725 NC_012633.1 756107 756319 R NACHT family NTPase complement(756107..756319) Rickettsia africae ESF-5 7815702 YP_002845359.1 CDS nuoN1 NC_012633.1 757598 758974 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 757598..758974 Rickettsia africae ESF-5 7815703 YP_002845360.1 CDS RAF_ORF0727 NC_012633.1 758961 760502 R hypothetical protein complement(758961..760502) Rickettsia africae ESF-5 7815704 YP_002845361.1 CDS hemB NC_012633.1 760591 761592 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(760591..761592) Rickettsia africae ESF-5 7815705 YP_002845362.1 CDS priA NC_012633.1 762781 764727 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(762781..764727) Rickettsia africae ESF-5 7815707 YP_002845363.1 CDS ubiX NC_012633.1 764791 765366 D aromatic acid decarboxylase 764791..765366 Rickettsia africae ESF-5 7815708 YP_002845364.1 CDS dnaB NC_012633.1 765733 767217 D unwinds double stranded DNA; replicative DNA helicase 765733..767217 Rickettsia africae ESF-5 7815709 YP_002845365.1 CDS RAF_ORF0735 NC_012633.1 768058 768213 R amino acid permease complement(768058..768213) Rickettsia africae ESF-5 7815710 YP_002845366.1 CDS rluA2 NC_012633.1 769085 769777 D Ribosomal large subunit pseudouridine synthase 769085..769777 Rickettsia africae ESF-5 7815711 YP_002845367.1 CDS RAF_ORF0737 NC_012633.1 769824 772697 D hypothetical protein 769824..772697 Rickettsia africae ESF-5 7815712 YP_002845368.1 CDS RAF_ORF0738 NC_012633.1 772702 773439 D N6-adenine-specific methylase 772702..773439 Rickettsia africae ESF-5 7815713 YP_002845369.1 CDS radA NC_012633.1 773585 774919 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 773585..774919 Rickettsia africae ESF-5 7815714 YP_002845370.1 CDS RAF_ORF0740 NC_012633.1 774916 775230 D hypothetical protein 774916..775230 Rickettsia africae ESF-5 7815715 YP_002845371.1 CDS recO NC_012633.1 775351 776064 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 775351..776064 Rickettsia africae ESF-5 7815716 YP_002845372.1 CDS RAF_ORF0742 NC_012633.1 776513 777211 D Putative glycoprotein endopeptidase 776513..777211 Rickettsia africae ESF-5 7815717 YP_002845373.1 CDS RAF_ORF0743 NC_012633.1 777262 778035 R hypothetical protein complement(777262..778035) Rickettsia africae ESF-5 7815718 YP_002845374.1 CDS infB NC_012633.1 778883 781378 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(778883..781378) Rickettsia africae ESF-5 7815719 YP_002845375.1 CDS nusA NC_012633.1 781618 783129 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(781618..783129) Rickettsia africae ESF-5 7815720 YP_002845376.1 CDS RAF_ORF0746 NC_012633.1 783140 783625 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(783140..783625) Rickettsia africae ESF-5 7815721 YP_002845377.1 CDS RAF_ORF0747 NC_012633.1 784747 785040 R hypothetical protein complement(784747..785040) Rickettsia africae ESF-5 7815722 YP_002845378.1 CDS RAF_ORF0748 NC_012633.1 785162 785590 D Putative transcriptional regulator 785162..785590 Rickettsia africae ESF-5 7815723 YP_002845379.1 CDS tlyA NC_012633.1 785585 786340 R Hemolysin A complement(785585..786340) Rickettsia africae ESF-5 7815724 YP_002845380.1 CDS tyrS NC_012633.1 786499 787734 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(786499..787734) Rickettsia africae ESF-5 7815725 YP_002845381.1 CDS RAF_ORF0751 NC_012633.1 787821 788018 R hypothetical protein complement(787821..788018) Rickettsia africae ESF-5 7815726 YP_002845382.1 CDS RAF_ORF0752 NC_012633.1 788024 788188 R hypothetical protein complement(788024..788188) Rickettsia africae ESF-5 7815727 YP_002845383.1 CDS RAF_ORF0753 NC_012633.1 788343 788636 D hypothetical protein 788343..788636 Rickettsia africae ESF-5 7815728 YP_002845384.1 CDS RAF_ORF0754 NC_012633.1 790437 790916 R hypothetical protein complement(790437..790916) Rickettsia africae ESF-5 7815730 YP_002845385.1 CDS RAF_ORF0755 NC_012633.1 791376 791732 R hypothetical protein complement(791376..791732) Rickettsia africae ESF-5 7815731 YP_002845386.1 CDS RAF_ORF0756 NC_012633.1 792498 793076 R hypothetical protein complement(792498..793076) Rickettsia africae ESF-5 7815732 YP_002845387.1 CDS proP8 NC_012633.1 793169 793396 R Proline/betaine transporter complement(793169..793396) Rickettsia africae ESF-5 7815733 YP_002845388.1 CDS RAF_ORF0758 NC_012633.1 793518 793919 R hypothetical protein complement(793518..793919) Rickettsia africae ESF-5 7815734 YP_002845389.1 CDS RAF_ORF0759 NC_012633.1 794375 800053 D Large extracellular alpha-helical protein 794375..800053 Rickettsia africae ESF-5 7815735 YP_002845390.1 CDS comF2 NC_012633.1 802506 802871 R Competence protein F complement(802506..802871) Rickettsia africae ESF-5 7815737 YP_002845391.1 CDS comF1 NC_012633.1 802864 803211 R Competence protein F complement(802864..803211) Rickettsia africae ESF-5 7815738 YP_002845392.1 CDS RAF_ORF0770 NC_012633.1 804550 804816 R hypothetical protein complement(804550..804816) Rickettsia africae ESF-5 7814856 YP_002845393.1 CDS ubiH NC_012633.1 804994 806289 R Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase complement(804994..806289) Rickettsia africae ESF-5 7815579 YP_002845394.1 CDS RAF_ORF0772 NC_012633.1 806261 806527 R subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit F complement(806261..806527) Rickettsia africae ESF-5 7815580 YP_002845395.1 CDS ntrX NC_012633.1 807044 808468 D Nitrogen assimilation regulatory protein NtrX 807044..808468 Rickettsia africae ESF-5 7815581 YP_002845396.1 CDS RAF_ORF0774 NC_012633.1 808437 810206 D hypothetical protein 808437..810206 Rickettsia africae ESF-5 7815582 YP_002845397.1 CDS RAF_ORF0775 NC_012633.1 810428 811387 R hypothetical protein complement(810428..811387) Rickettsia africae ESF-5 7815583 YP_002845398.1 CDS pbpA1 NC_012633.1 812063 813844 R Penicillin-binding protein complement(812063..813844) Rickettsia africae ESF-5 7815584 YP_002845399.1 CDS RAF_ORF0777 NC_012633.1 813834 814355 R hypothetical protein complement(813834..814355) Rickettsia africae ESF-5 7815585 YP_002845400.1 CDS pbpA2 NC_012633.1 814974 816656 R Penicillin-binding protein complement(814974..816656) Rickettsia africae ESF-5 7815586 YP_002845401.1 CDS ftsL NC_012633.1 817000 817398 R Cell division protein FtsL complement(817000..817398) Rickettsia africae ESF-5 7815587 YP_002845402.1 CDS mraW NC_012633.1 817405 818328 R S-adenosyl-methyltransferase MraW complement(817405..818328) Rickettsia africae ESF-5 7815588 YP_002845403.1 CDS mraZ NC_012633.1 818328 818777 R MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ complement(818328..818777) Rickettsia africae ESF-5 7815589 YP_002845404.1 CDS RAF_ORF0782 NC_012633.1 819191 819709 D Ankyrin repeat protein 819191..819709 Rickettsia africae ESF-5 7815590 YP_002845405.1 CDS panF NC_012633.1 820358 821755 D Sodium/pantothenate symporter 820358..821755 Rickettsia africae ESF-5 7815591 YP_002845406.1 CDS uvrC NC_012633.1 822382 824301 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C complement(822382..824301) Rickettsia africae ESF-5 7815592 YP_002845407.1 CDS RAF_ORF0785 NC_012633.1 824476 825009 R hypothetical protein complement(824476..825009) Rickettsia africae ESF-5 7815593 YP_002845408.1 CDS RAF_ORF0786 NC_012633.1 825199 825591 R Putative DNA alkylation repair enzyme complement(825199..825591) Rickettsia africae ESF-5 7815594 YP_002845409.1 CDS dat NC_012633.1 826884 827390 R Methylated-DNA--protein-cysteine methyltransferase complement(826884..827390) Rickettsia africae ESF-5 7815596 YP_002845410.1 CDS RAF_ORF0793 NC_012633.1 829744 830217 R hypothetical protein complement(829744..830217) Rickettsia africae ESF-5 7815598 YP_002845411.1 CDS RAF_ORF0794 NC_012633.1 830788 830997 R hypothetical protein complement(830788..830997) Rickettsia africae ESF-5 7815600 YP_002845412.1 CDS RAF_ORF0795 NC_012633.1 831323 831565 R Ankyrin repeat protein complement(831323..831565) Rickettsia africae ESF-5 7815601 YP_002845413.1 CDS secA NC_012633.1 832626 835346 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(832626..835346) Rickettsia africae ESF-5 7815602 YP_002845414.1 CDS prsA NC_012633.1 835562 836410 D Protein export protein prsA precursor 835562..836410 Rickettsia africae ESF-5 7815603 YP_002845415.1 CDS acpS NC_012633.1 836620 837015 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(836620..837015) Rickettsia africae ESF-5 7815604 YP_002845416.1 CDS rpoZ NC_012633.1 837016 837399 R Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(837016..837399) Rickettsia africae ESF-5 7815605 YP_002845417.1 CDS murA NC_012633.1 837588 838847 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(837588..838847) Rickettsia africae ESF-5 7815606 YP_002845418.1 CDS gyrB NC_012633.1 838939 841362 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(838939..841362) Rickettsia africae ESF-5 7815607 YP_002845419.1 CDS RAF_ORF0802 NC_012633.1 841642 842502 D HAD-superfamily hydrolase 841642..842502 Rickettsia africae ESF-5 7815608 YP_002845420.1 CDS mgtE NC_012633.1 843008 844378 D Magnesium transporter 843008..844378 Rickettsia africae ESF-5 7815610 YP_002845421.1 CDS RAF_ORF0804 NC_012633.1 844382 844669 R hypothetical protein complement(844382..844669) Rickettsia africae ESF-5 7815611 YP_002845422.1 CDS spoT3 NC_012633.1 845228 845497 D Guanosine polyphosphate pyrophosphohydrolase/synthetase 845228..845497 Rickettsia africae ESF-5 7815612 YP_002845423.1 CDS proP9 NC_012633.1 845714 846112 R Proline/betaine transporter complement(845714..846112) Rickettsia africae ESF-5 7815613 YP_002845424.1 CDS yajC NC_012633.1 848009 848623 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 848009..848623 Rickettsia africae ESF-5 7815616 YP_002845425.1 CDS secD NC_012633.1 848607 850163 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 848607..850163 Rickettsia africae ESF-5 7815617 YP_002845426.1 CDS RAF_ORF0811 NC_012633.1 850408 851028 D Sco2 protein precursor 850408..851028 Rickettsia africae ESF-5 7815618 YP_002845427.1 CDS RAF_ORF0812 NC_012633.1 851021 851152 D hypothetical protein 851021..851152 Rickettsia africae ESF-5 7815619 YP_002845428.1 CDS ccmE NC_012633.1 851130 851516 D CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 851130..851516 Rickettsia africae ESF-5 7815620 YP_002845429.1 CDS ppa NC_012633.1 851642 852163 D catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 851642..852163 Rickettsia africae ESF-5 7815621 YP_002845430.1 CDS mviN NC_012633.1 852374 854041 D Integral membrane protein MviN 852374..854041 Rickettsia africae ESF-5 7815622 YP_002845431.1 CDS traX NC_012633.1 854022 854774 D F pilin acetylation protein TraX 854022..854774 Rickettsia africae ESF-5 7815623 YP_002845432.1 CDS RAF_ORF0817 NC_012633.1 854848 855450 D hypothetical protein 854848..855450 Rickettsia africae ESF-5 7815624 YP_002845433.1 CDS recG NC_012633.1 855658 857799 R ATP-dependent DNA helicase RecG complement(855658..857799) Rickettsia africae ESF-5 7815625 YP_002845434.1 CDS RAF_ORF0819 NC_012633.1 858072 858644 R hypothetical protein complement(858072..858644) Rickettsia africae ESF-5 7815626 YP_002845435.1 CDS scoA NC_012633.1 859213 859854 D Succinyl-CoA:3-ketoacid-coenzyme A transferase 859213..859854 Rickettsia africae ESF-5 7815627 YP_002845436.1 CDS scoB NC_012633.1 859858 860493 D Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B 859858..860493 Rickettsia africae ESF-5 7815628 YP_002845437.1 CDS rickA NC_012633.1 861131 862633 R Actin polymerization protein RickA complement(861131..862633) Rickettsia africae ESF-5 7815630 YP_002845438.1 CDS mraY NC_012633.1 862743 863828 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(862743..863828) Rickettsia africae ESF-5 7815631 YP_002845439.1 CDS murF NC_012633.1 864023 865372 R UDP-N-acetylmuramoylalanyl-D-glutamyl- 2,6-diaminopimelate--D-alanyl-D-alanyl ligase complement(864023..865372) Rickettsia africae ESF-5 7815632 YP_002845440.1 CDS murE NC_012633.1 865581 867020 R involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase complement(865581..867020) Rickettsia africae ESF-5 7815633 YP_002845441.1 CDS mfd NC_012633.1 867167 870535 R transcription-repair coupling factor complement(867167..870535) Rickettsia africae ESF-5 7815634 YP_002845442.1 CDS RAF_ORF0829 NC_012633.1 870547 870810 R hypothetical protein complement(870547..870810) Rickettsia africae ESF-5 7815635 YP_002845443.1 CDS pspE NC_012633.1 870972 871343 D Rhodanese-related sulfurtransferase 870972..871343 Rickettsia africae ESF-5 7815636 YP_002845444.1 CDS dnaA NC_012633.1 871344 872735 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 871344..872735 Rickettsia africae ESF-5 7815637 YP_002845445.1 CDS RAF_ORF0834 NC_012633.1 875425 875670 R hypothetical protein complement(875425..875670) Rickettsia africae ESF-5 7815639 YP_002845446.1 CDS pat1 NC_012633.1 875866 877338 D Patatin-like phospholipase 875866..877338 Rickettsia africae ESF-5 7815640 YP_002845447.1 CDS ychF NC_012633.1 879671 880768 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(879671..880768) Rickettsia africae ESF-5 7815643 YP_002845448.1 CDS RAF_ORF0842 NC_012633.1 880765 880935 R Acetyltransferase complement(880765..880935) Rickettsia africae ESF-5 7815644 YP_002845449.1 CDS pth NC_012633.1 881397 881954 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(881397..881954) Rickettsia africae ESF-5 7815645 YP_002845450.1 CDS rplY NC_012633.1 882277 882888 R the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25/general stress protein Ctc complement(882277..882888) Rickettsia africae ESF-5 7815646 YP_002845451.1 CDS nrdG NC_012633.1 883634 884311 R Organic radical activating enzyme complement(883634..884311) Rickettsia africae ESF-5 7815647 YP_002845452.1 CDS rpmI NC_012633.1 884415 884684 D 50S ribosomal protein L35 884415..884684 Rickettsia africae ESF-5 7815648 YP_002845453.1 CDS rplT NC_012633.1 884704 885057 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 884704..885057 Rickettsia africae ESF-5 7815649 YP_002845454.1 CDS rpmH NC_012633.1 885140 885274 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 885140..885274 Rickettsia africae ESF-5 7815650 YP_002845455.1 CDS rnpA NC_012633.1 885294 885650 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 885294..885650 Rickettsia africae ESF-5 7815651 YP_002845456.1 CDS RAF_ORF0850 NC_012633.1 886159 888099 R hypothetical protein complement(886159..888099) Rickettsia africae ESF-5 7815652 YP_002845457.1 CDS RAF_ORF0851 NC_012633.1 889694 890011 R hypothetical protein complement(889694..890011) Rickettsia africae ESF-5 7815653 YP_002845458.1 CDS corA NC_012633.1 890229 891188 R Magnesium and cobalt transport protein CorA complement(890229..891188) Rickettsia africae ESF-5 7815654 YP_002845459.1 CDS RAF_ORF0853 NC_012633.1 891877 892260 R hypothetical protein complement(891877..892260) Rickettsia africae ESF-5 7815655 YP_002845460.1 CDS ntrY NC_012633.1 895942 897741 R Nitrogen regulation protein NtrY complement(895942..897741) Rickettsia africae ESF-5 7815658 YP_002845461.1 CDS rpsU NC_012633.1 898108 898308 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(898108..898308) Rickettsia africae ESF-5 7815256 YP_002845462.1 CDS RAF_ORF0858 NC_012633.1 898333 898998 D hypothetical protein 898333..898998 Rickettsia africae ESF-5 7814857 YP_002845463.1 CDS ileS NC_012633.1 899989 903267 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 899989..903267 Rickettsia africae ESF-5 7814858 YP_002845464.1 CDS RAF_ORF0860 NC_012633.1 903731 904012 D Ankyrin repeat protein 903731..904012 Rickettsia africae ESF-5 7814859 YP_002845465.1 CDS RAF_ORF0861 NC_012633.1 905074 905301 D hypothetical protein 905074..905301 Rickettsia africae ESF-5 7814860 YP_002845466.1 CDS accC NC_012633.1 905612 907609 R Acetyl-CoA carboxylase, biotin carboxylase complement(905612..907609) Rickettsia africae ESF-5 7814861 YP_002845467.1 CDS pccB NC_012633.1 907707 909251 R Propionyl-CoA carboxylase beta chain precursor complement(907707..909251) Rickettsia africae ESF-5 7814862 YP_002845468.1 CDS RAF_ORF0864 NC_012633.1 909327 909575 D hypothetical protein 909327..909575 Rickettsia africae ESF-5 7814863 YP_002845469.1 CDS aas NC_012633.1 909810 913232 D Synthesizes thioester adducts of fatty acids enzymatically to the phosphopantetheine group of acyl carrier protein; acylglycerophosphoethanolamine acyltransferase 909810..913232 Rickettsia africae ESF-5 7814864 YP_002845470.1 CDS tfoX NC_012633.1 913499 913705 R Regulator of competence-specific genes TfoX complement(913499..913705) Rickettsia africae ESF-5 7814865 YP_002845471.1 CDS znuB NC_012633.1 913702 914463 R Zinc/manganese ABC transporter permease protein complement(913702..914463) Rickettsia africae ESF-5 7814866 YP_002845472.1 CDS ubiG NC_012633.1 914601 915470 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 914601..915470 Rickettsia africae ESF-5 7814867 YP_002845473.1 CDS gltX NC_012633.1 915769 917310 D Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 915769..917310 Rickettsia africae ESF-5 7814868 YP_002845474.1 CDS RAF_ORF0870 NC_012633.1 917307 917843 D hypothetical protein 917307..917843 Rickettsia africae ESF-5 7814869 YP_002845475.1 CDS groEL NC_012633.1 918802 920445 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL complement(918802..920445) Rickettsia africae ESF-5 7814870 YP_002845476.1 CDS groES NC_012633.1 920473 920772 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(920473..920772) Rickettsia africae ESF-5 7814871 YP_002845477.1 CDS RAF_ORF0876 NC_012633.1 922814 923296 R hypothetical protein complement(922814..923296) Rickettsia africae ESF-5 7814873 YP_002845478.1 CDS rph NC_012633.1 923998 924717 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(923998..924717) Rickettsia africae ESF-5 7814874 YP_002845479.1 CDS grpE NC_012633.1 924941 925477 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 924941..925477 Rickettsia africae ESF-5 7814875 YP_002845480.1 CDS perM NC_012633.1 925606 926676 D Permease PerM-like protein 925606..926676 Rickettsia africae ESF-5 7814876 YP_002845481.1 CDS RAF_ORF0880 NC_012633.1 926692 927360 D hypothetical protein 926692..927360 Rickettsia africae ESF-5 7814877 YP_002845482.1 CDS RAF_ORF0881 NC_012633.1 927668 927910 D MFS-type sugar transporter 927668..927910 Rickettsia africae ESF-5 7814878 YP_002845483.1 CDS RAF_ORF0882 NC_012633.1 928659 928892 R hypothetical protein complement(928659..928892) Rickettsia africae ESF-5 7814879 YP_002845484.1 CDS rpsT NC_012633.1 930496 930774 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(930496..930774) Rickettsia africae ESF-5 7814882 YP_002845485.1 CDS rplQ NC_012633.1 930793 931203 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(930793..931203) Rickettsia africae ESF-5 7814883 YP_002845486.1 CDS rpoA NC_012633.1 931214 932236 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(931214..932236) Rickettsia africae ESF-5 7814884 YP_002845487.1 CDS rpsK NC_012633.1 932255 932638 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(932255..932638) Rickettsia africae ESF-5 7814885 YP_002845488.1 CDS rpsM NC_012633.1 932663 933040 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(932663..933040) Rickettsia africae ESF-5 7814886 YP_002845489.1 CDS adk NC_012633.1 933099 933737 R essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase complement(933099..933737) Rickettsia africae ESF-5 7814887 YP_002845490.1 CDS secY NC_012633.1 933753 935054 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(933753..935054) Rickettsia africae ESF-5 7814888 YP_002845491.1 CDS rplO NC_012633.1 935058 935519 R late assembly protein; 50S ribosomal protein L15 complement(935058..935519) Rickettsia africae ESF-5 7814889 YP_002845492.1 CDS rpmD NC_012633.1 935533 935724 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(935533..935724) Rickettsia africae ESF-5 7814890 YP_002845493.1 CDS rpsE NC_012633.1 935748 936278 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(935748..936278) Rickettsia africae ESF-5 7814891 YP_002845494.1 CDS rplR NC_012633.1 936296 936652 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(936296..936652) Rickettsia africae ESF-5 7814892 YP_002845495.1 CDS rplF NC_012633.1 936668 937201 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(936668..937201) Rickettsia africae ESF-5 7814893 YP_002845496.1 CDS rpsH NC_012633.1 937210 937608 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(937210..937608) Rickettsia africae ESF-5 7814894 YP_002845497.1 CDS rpsN NC_012633.1 937628 937933 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(937628..937933) Rickettsia africae ESF-5 7814895 YP_002845498.1 CDS rplE NC_012633.1 937951 938490 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(937951..938490) Rickettsia africae ESF-5 7814896 YP_002845499.1 CDS rplX NC_012633.1 938490 938819 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(938490..938819) Rickettsia africae ESF-5 7814897 YP_002845500.1 CDS rplN NC_012633.1 938820 939188 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(938820..939188) Rickettsia africae ESF-5 7814898 YP_002845501.1 CDS rpsQ NC_012633.1 939263 939511 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(939263..939511) Rickettsia africae ESF-5 7814899 YP_002845502.1 CDS rpmC NC_012633.1 939498 939713 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(939498..939713) Rickettsia africae ESF-5 7814900 YP_002845503.1 CDS rplP NC_012633.1 939706 940116 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(939706..940116) Rickettsia africae ESF-5 7814901 YP_002845504.1 CDS rpsC NC_012633.1 940131 940784 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(940131..940784) Rickettsia africae ESF-5 7814902 YP_002845505.1 CDS rplV NC_012633.1 940786 941145 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(940786..941145) Rickettsia africae ESF-5 7814903 YP_002845506.1 CDS rpsS NC_012633.1 941154 941432 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(941154..941432) Rickettsia africae ESF-5 7814904 YP_002845507.1 CDS rplB NC_012633.1 941457 942278 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(941457..942278) Rickettsia africae ESF-5 7814905 YP_002845508.1 CDS rplW NC_012633.1 942279 942575 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(942279..942575) Rickettsia africae ESF-5 7814906 YP_002845509.1 CDS rplD NC_012633.1 942572 943195 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(942572..943195) Rickettsia africae ESF-5 7814907 YP_002845510.1 CDS rplC NC_012633.1 943306 943953 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(943306..943953) Rickettsia africae ESF-5 7814908 YP_002845511.1 CDS rpsJ NC_012633.1 943954 944271 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(943954..944271) Rickettsia africae ESF-5 7814909 YP_002845512.1 CDS tuf NC_012633.1 944513 945697 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(944513..945697) Rickettsia africae ESF-5 7814910 YP_002845513.1 CDS RAF_ORF0915 NC_012633.1 946274 946996 D tRNA/rRNA methyltransferase 946274..946996 Rickettsia africae ESF-5 7814913 YP_002845514.1 CDS RAF_ORF0916 NC_012633.1 947096 947548 D hypothetical protein 947096..947548 Rickettsia africae ESF-5 7814914 YP_002845515.1 CDS fumC NC_012633.1 947545 948936 D class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 947545..948936 Rickettsia africae ESF-5 7814915 YP_002845516.1 CDS RAF_ORF0918 NC_012633.1 949033 949281 D Antitoxin of toxin-antitoxin (TA) system Phd 949033..949281 Rickettsia africae ESF-5 7814916 YP_002845517.1 CDS RAF_ORF0919 NC_012633.1 949275 949598 D Toxin of toxin-antitoxin (TA) system, containing PIN domain for nucleic acid binding 949275..949598 Rickettsia africae ESF-5 7814917 YP_002845518.1 CDS ftsZ NC_012633.1 949779 951137 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 949779..951137 Rickettsia africae ESF-5 7814918 YP_002845519.1 CDS RAF_ORF0921 NC_012633.1 951411 952061 D hypothetical protein 951411..952061 Rickettsia africae ESF-5 7814919 YP_002845520.1 CDS ecoT NC_012633.1 952155 952451 D Ecotin precursor 952155..952451 Rickettsia africae ESF-5 7814920 YP_002845521.1 CDS RAF_ORF0923 NC_012633.1 952669 953241 R NifU-like protein complement(952669..953241) Rickettsia africae ESF-5 7814921 YP_002845522.1 CDS ampG2 NC_012633.1 953589 954653 R AmpG protein complement(953589..954653) Rickettsia africae ESF-5 7814922 YP_002845523.1 CDS rhlE NC_012633.1 955009 956241 R ATP-dependent RNA helicase RhlE complement(955009..956241) Rickettsia africae ESF-5 7814923 YP_002845524.1 CDS cspA NC_012633.1 956755 956967 R Cold shock-like protein complement(956755..956967) Rickettsia africae ESF-5 7814924 YP_002845525.1 CDS RAF_ORF0927 NC_012633.1 957083 957211 D hypothetical protein 957083..957211 Rickettsia africae ESF-5 7814925 YP_002845526.1 CDS ksgA NC_012633.1 958368 959273 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(958368..959273) Rickettsia africae ESF-5 7814927 YP_002845527.1 CDS RAF_ORF0929 NC_012633.1 959427 960314 R hypothetical protein complement(959427..960314) Rickettsia africae ESF-5 7814928 YP_002845528.1 CDS ostA NC_012633.1 960470 962272 R Organic solvent tolerance protein-like protein complement(960470..962272) Rickettsia africae ESF-5 7814929 YP_002845529.1 CDS RAF_ORF0931 NC_012633.1 962274 962405 D hypothetical protein 962274..962405 Rickettsia africae ESF-5 7814930 YP_002845530.1 CDS xseA NC_012633.1 962877 964211 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 962877..964211 Rickettsia africae ESF-5 7814931 YP_002845531.1 CDS RAF_ORF0933 NC_012633.1 964217 964534 D hypothetical protein 964217..964534 Rickettsia africae ESF-5 7814932 YP_002845532.1 CDS xth2 NC_012633.1 964888 965670 D Exodeoxyribonuclease III 964888..965670 Rickettsia africae ESF-5 7814933 YP_002845533.1 CDS RAF_ORF0935 NC_012633.1 965866 966132 D hypothetical protein 965866..966132 Rickettsia africae ESF-5 7814934 YP_002845534.1 CDS engA NC_012633.1 966136 967479 D EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 966136..967479 Rickettsia africae ESF-5 7814935 YP_002845535.1 CDS RAF_ORF0937 NC_012633.1 967630 968772 R Putative AAA+ superfamily ATPase complement(967630..968772) Rickettsia africae ESF-5 7814936 YP_002845536.1 CDS ubiB NC_012633.1 971421 972857 R 2-polyprenylphenol 6-hydroxylase complement(971421..972857) Rickettsia africae ESF-5 7815930 YP_002845537.1 CDS ubiE NC_012633.1 973005 973751 R Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase complement(973005..973751) Rickettsia africae ESF-5 7815931 YP_002845538.1 CDS mutM NC_012633.1 973780 974601 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 973780..974601 Rickettsia africae ESF-5 7815932 YP_002845539.1 CDS RAF_ORF0946 NC_012633.1 975906 976160 D hypothetical protein 975906..976160 Rickettsia africae ESF-5 7815934 YP_002845540.1 CDS RAF_ORF0947 NC_012633.1 976542 976802 D hypothetical protein 976542..976802 Rickettsia africae ESF-5 7815935 YP_002845541.1 CDS tatD NC_012633.1 979418 980338 R deoxyribonuclease TatD complement(979418..980338) Rickettsia africae ESF-5 7815937 YP_002845542.1 CDS metG NC_012633.1 980391 981917 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(980391..981917) Rickettsia africae ESF-5 7815938 YP_002845543.1 CDS tmk NC_012633.1 981914 982525 R catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase complement(981914..982525) Rickettsia africae ESF-5 7815939 YP_002845544.1 CDS proP4 NC_012633.1 982784 984172 D Proline/betaine transporter 982784..984172 Rickettsia africae ESF-5 7815940 YP_002845545.1 CDS ubiA NC_012633.1 984197 985045 R UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; 4-hydroxybenzoate polyprenyltransferase complement(984197..985045) Rickettsia africae ESF-5 7815941 YP_002845546.1 CDS valS NC_012633.1 986173 988611 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 986173..988611 Rickettsia africae ESF-5 7815943 YP_002845547.1 CDS RAF_ORF0958 NC_012633.1 988765 989334 D LPS biosynthesis protein 988765..989334 Rickettsia africae ESF-5 7815944 YP_002845548.1 CDS RAF_ORF0959 NC_012633.1 989424 990224 D LPS biosynthesis protein 989424..990224 Rickettsia africae ESF-5 7815945 YP_002845549.1 CDS RAF_ORF0962 NC_012633.1 991973 993259 D RmuC family protein 991973..993259 Rickettsia africae ESF-5 7815947 YP_002845550.1 CDS RAF_ORF0965 NC_012633.1 994541 994858 D LPS biosynthesis glycosyltransferase 994541..994858 Rickettsia africae ESF-5 7815949 YP_002845551.1 CDS RAF_ORF0973 NC_012633.1 998603 998911 D Putative integral membrane protein 998603..998911 Rickettsia africae ESF-5 7815952 YP_002845552.1 CDS clpX NC_012633.1 999150 1000427 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(999150..1000427) Rickettsia africae ESF-5 7815953 YP_002845553.1 CDS rimJ NC_012633.1 1000465 1001016 R Ribosomal-protein-alanine acetyltransferase complement(1000465..1001016) Rickettsia africae ESF-5 7815954 YP_002845554.1 CDS exsB NC_012633.1 1001176 1001862 R Trans-regulatory protein ExsB complement(1001176..1001862) Rickettsia africae ESF-5 7815955 YP_002845555.1 CDS RAF_ORF0977 NC_012633.1 1001859 1002209 R HicB-like protein complement(1001859..1002209) Rickettsia africae ESF-5 7815956 YP_002845556.1 CDS msbA2 NC_012633.1 1002825 1004555 D Multidrug resistance protein 1002825..1004555 Rickettsia africae ESF-5 7815958 YP_002845557.1 CDS RAF_ORF0979 NC_012633.1 1004858 1005106 D hypothetical protein 1004858..1005106 Rickettsia africae ESF-5 7815959 YP_002845558.1 CDS bcr2 NC_012633.1 1005773 1006945 D MFS-type bicyclomycin resistance protein 1005773..1006945 Rickettsia africae ESF-5 7815960 YP_002845559.1 CDS RAF_ORF0981 NC_012633.1 1007127 1008377 D Lipoprotein releasing system, transmembrane protein, LolC/E family protein 1007127..1008377 Rickettsia africae ESF-5 7815961 YP_002845560.1 CDS lolD NC_012633.1 1008370 1009035 D Lipoprotein releasing system ATP-binding protein LolD 1008370..1009035 Rickettsia africae ESF-5 7815962 YP_002845561.1 CDS RAF_ORF0983 NC_012633.1 1009254 1011155 D hypothetical protein 1009254..1011155 Rickettsia africae ESF-5 7815963 YP_002845562.1 CDS RAF_ORF0984 NC_012633.1 1011230 1012504 D Hemolysin-like protein 1011230..1012504 Rickettsia africae ESF-5 7815964 YP_002845563.1 CDS ccmF NC_012633.1 1012497 1014485 D Cytochrome c-type biogenesis protein ccmF 1012497..1014485 Rickettsia africae ESF-5 7815965 YP_002845564.1 CDS ompB NC_012633.1 1017088 1022052 R outer membrane protein OmpB complement(1017088..1022052) Rickettsia africae ESF-5 7815967 YP_002845565.1 CDS spoT11 NC_012633.1 1022444 1023049 R Guanosine polyphosphate pyrophosphohydrolase/synthetase complement(1022444..1023049) Rickettsia africae ESF-5 7815968 YP_002845566.1 CDS RAF_ORF0992 NC_012633.1 1023414 1024397 R Beta-glucosidase complement(1023414..1024397) Rickettsia africae ESF-5 7815969 YP_002845567.1 CDS RAF_ORF0993 NC_012633.1 1024401 1024724 R hypothetical protein complement(1024401..1024724) Rickettsia africae ESF-5 7815970 YP_002845568.1 CDS himA NC_012633.1 1024913 1025200 R Integration host factor alpha-subunit complement(1024913..1025200) Rickettsia africae ESF-5 7815971 YP_002845569.1 CDS RAF_ORF0995 NC_012633.1 1025348 1025815 R hypothetical protein complement(1025348..1025815) Rickettsia africae ESF-5 7815972 YP_002845570.1 CDS bcp NC_012633.1 1026325 1026795 D Bacterioferritin comigratory protein 1026325..1026795 Rickettsia africae ESF-5 7815973 YP_002845571.1 CDS htrB NC_012633.1 1026915 1027787 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(1026915..1027787) Rickettsia africae ESF-5 7815974 YP_002845572.1 CDS lpxK NC_012633.1 1027762 1028727 R transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase complement(1027762..1028727) Rickettsia africae ESF-5 7815975 YP_002845573.1 CDS RAF_ORF0999 NC_012633.1 1028731 1029585 R Periplasmic protein complement(1028731..1029585) Rickettsia africae ESF-5 7815976 YP_002845574.1 CDS RAF_ORF1002 NC_012633.1 1030670 1030978 R Putative virulence protein complement(1030670..1030978) Rickettsia africae ESF-5 7815978 YP_002845575.1 CDS ligA NC_012633.1 1031092 1033161 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(1031092..1033161) Rickettsia africae ESF-5 7815979 YP_002845576.1 CDS RAF_ORF1004 NC_012633.1 1033263 1033400 R hypothetical protein complement(1033263..1033400) Rickettsia africae ESF-5 7815980 YP_002845577.1 CDS tgt NC_012633.1 1033448 1034533 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(1033448..1034533) Rickettsia africae ESF-5 7815981 YP_002845578.1 CDS RAF_ORF1011 NC_012633.1 1037491 1038045 D hypothetical protein 1037491..1038045 Rickettsia africae ESF-5 7815984 YP_002845579.1 CDS RAF_ORF1012 NC_012633.1 1038400 1038528 R hypothetical protein complement(1038400..1038528) Rickettsia africae ESF-5 7815985 YP_002845580.1 CDS RAF_ORF1013 NC_012633.1 1038699 1038839 R hypothetical protein complement(1038699..1038839) Rickettsia africae ESF-5 7815986 YP_002845581.1 CDS RAF_ORF1014 NC_012633.1 1039147 1039596 R ABC transporter substrate-binding protein complement(1039147..1039596) Rickettsia africae ESF-5 7815987 YP_002845582.1 CDS RAF_ORF1015 NC_012633.1 1039621 1039920 R hypothetical protein complement(1039621..1039920) Rickettsia africae ESF-5 7815988 YP_002845583.1 CDS rnhA NC_012633.1 1039908 1040375 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H complement(1039908..1040375) Rickettsia africae ESF-5 7815989 YP_002845584.1 CDS RAF_ORF1017 NC_012633.1 1040375 1040851 R hypothetical protein complement(1040375..1040851) Rickettsia africae ESF-5 7815990 YP_002845585.1 CDS RAF_ORF1018 NC_012633.1 1041631 1042443 D hypothetical protein 1041631..1042443 Rickettsia africae ESF-5 7815992 YP_002845586.1 CDS coaE NC_012633.1 1042437 1043012 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 1042437..1043012 Rickettsia africae ESF-5 7815993 YP_002845587.1 CDS dnaQ NC_012633.1 1043000 1043689 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 1043000..1043689 Rickettsia africae ESF-5 7815994 YP_002845588.1 CDS surf1 NC_012633.1 1043816 1044538 D Surfeit locus protein 1 1043816..1044538 Rickettsia africae ESF-5 7815995 YP_002845589.1 CDS RAF_ORF1022 NC_012633.1 1044594 1047062 D ATP-dependent helicase 1044594..1047062 Rickettsia africae ESF-5 7815996 YP_002845590.1 CDS RAF_ORF1023 NC_012633.1 1047543 1048112 R hypothetical protein complement(1047543..1048112) Rickettsia africae ESF-5 7815997 YP_002845591.1 CDS fabD NC_012633.1 1048321 1049265 D Malonyl CoA-acyl carrier protein transacylase 1048321..1049265 Rickettsia africae ESF-5 7815998 YP_002845592.1 CDS RAF_ORF1025 NC_012633.1 1050151 1050465 D hypothetical protein 1050151..1050465 Rickettsia africae ESF-5 7815999 YP_002845593.1 CDS RAF_ORF1026 NC_012633.1 1050998 1051363 R hypothetical protein complement(1050998..1051363) Rickettsia africae ESF-5 7816001 YP_002845594.1 CDS paaJ NC_012633.1 1058209 1059360 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(1058209..1059360) Rickettsia africae ESF-5 7816003 YP_002845595.1 CDS tlc5 NC_012633.1 1060635 1062134 D ATP/ADP translocase 1060635..1062134 Rickettsia africae ESF-5 7816005 YP_002845596.1 CDS RAF_ORF1038 NC_012633.1 1062657 1063031 R (Di)nucleoside polyphosphate hydrolase-like protein complement(1062657..1063031) Rickettsia africae ESF-5 7816006 YP_002845597.1 CDS tlyC NC_012633.1 1063703 1064602 R Hemolysin C complement(1063703..1064602) Rickettsia africae ESF-5 7816007 YP_002845598.1 CDS RAF_ORF1040 NC_012633.1 1064619 1065122 R putative metalloprotease complement(1064619..1065122) Rickettsia africae ESF-5 7816008 YP_002845599.1 CDS RAF_ORF1041 NC_012633.1 1065149 1065352 R PemK-like growth inhibitor complement(1065149..1065352) Rickettsia africae ESF-5 7816009 YP_002845600.1 CDS RAF_ORF1042 NC_012633.1 1065441 1065671 R hypothetical protein complement(1065441..1065671) Rickettsia africae ESF-5 7815740 YP_002845601.1 CDS lipA NC_012633.1 1065804 1066694 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(1065804..1066694) Rickettsia africae ESF-5 7815741 YP_002845602.1 CDS glyA NC_012633.1 1066687 1067949 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(1066687..1067949) Rickettsia africae ESF-5 7815742 YP_002845603.1 CDS RAF_ORF1045 NC_012633.1 1068064 1068714 R Serine esterase complement(1068064..1068714) Rickettsia africae ESF-5 7815743 YP_002845604.1 CDS grxC2 NC_012633.1 1068870 1069298 R Glutaredoxin-like protein grla complement(1068870..1069298) Rickettsia africae ESF-5 7815744 YP_002845605.1 CDS nth NC_012633.1 1069243 1069875 D Endonuclease III 1069243..1069875 Rickettsia africae ESF-5 7815745 YP_002845606.1 CDS RAF_ORF1050 NC_012633.1 1071463 1071657 D hypothetical protein 1071463..1071657 Rickettsia africae ESF-5 7815747 YP_002845607.1 CDS RAF_ORF1053 NC_012633.1 1072684 1073529 R Putative methyltransferase complement(1072684..1073529) Rickettsia africae ESF-5 7815749 YP_002845608.1 CDS RAF_ORF1054 NC_012633.1 1073554 1074672 D ABC transporter substrate-binding protein 1073554..1074672 Rickettsia africae ESF-5 7815750 YP_002845609.1 CDS tatA NC_012633.1 1074908 1075069 R TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A complement(1074908..1075069) Rickettsia africae ESF-5 7815751 YP_002845610.1 CDS pgpA NC_012633.1 1075150 1075749 D phosphatidylglycerophosphatase A 1075150..1075749 Rickettsia africae ESF-5 7815752 YP_002845611.1 CDS rplU NC_012633.1 1075838 1076155 D 50S ribosomal protein L21 1075838..1076155 Rickettsia africae ESF-5 7815753 YP_002845612.1 CDS rpmA NC_012633.1 1076180 1076440 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1076180..1076440 Rickettsia africae ESF-5 7815754 YP_002845613.1 CDS lysC NC_012633.1 1076721 1077926 D catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 1076721..1077926 Rickettsia africae ESF-5 7815755 YP_002845614.1 CDS RAF_ORF1060 NC_012633.1 1078213 1078707 D hypothetical protein 1078213..1078707 Rickettsia africae ESF-5 7815756 YP_002845615.1 CDS proP5 NC_012633.1 1080417 1081658 R Proline/betaine transporter complement(1080417..1081658) Rickettsia africae ESF-5 7815759 YP_002845616.1 CDS RAF_ORF1066 NC_012633.1 1081886 1082008 R hypothetical protein complement(1081886..1082008) Rickettsia africae ESF-5 7815760 YP_002845617.1 CDS RAF_ORF1067 NC_012633.1 1081986 1082303 R hypothetical protein complement(1081986..1082303) Rickettsia africae ESF-5 7815761 YP_002845618.1 CDS RAF_ORF1068 NC_012633.1 1082306 1082653 R hypothetical protein complement(1082306..1082653) Rickettsia africae ESF-5 7815762 YP_002845619.1 CDS RAF_ORF1069 NC_012633.1 1082660 1083013 R hypothetical protein complement(1082660..1083013) Rickettsia africae ESF-5 7815763 YP_002845620.1 CDS RAF_ORF1070 NC_012633.1 1083017 1087768 R NAD-specific glutamate dehydrogenase complement(1083017..1087768) Rickettsia africae ESF-5 7815764 YP_002845621.1 CDS trmE NC_012633.1 1087853 1089190 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1087853..1089190 Rickettsia africae ESF-5 7815765 YP_002845622.1 CDS RAF_ORF1072 NC_012633.1 1089576 1090877 D hypothetical protein 1089576..1090877 Rickettsia africae ESF-5 7815766 YP_002845623.1 CDS recA NC_012633.1 1093360 1094391 D catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1093360..1094391 Rickettsia africae ESF-5 7815769 YP_002845624.1 CDS fabG NC_012633.1 1094384 1095109 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1094384..1095109 Rickettsia africae ESF-5 7815770 YP_002845625.1 CDS acpP NC_012633.1 1095273 1095533 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1095273..1095533 Rickettsia africae ESF-5 7815771 YP_002845626.1 CDS fabF NC_012633.1 1095566 1096852 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 1095566..1096852 Rickettsia africae ESF-5 7815772 YP_002845627.1 CDS uup NC_012633.1 1097134 1098915 D ABC transporter ATP-binding protein 1097134..1098915 Rickettsia africae ESF-5 7815773 YP_002845628.1 CDS RAF_ORF1082 NC_012633.1 1098983 1100062 D hypothetical protein 1098983..1100062 Rickettsia africae ESF-5 7815774 YP_002845629.1 CDS gmk NC_012633.1 1101496 1102185 R guanylate kinase complement(1101496..1102185) Rickettsia africae ESF-5 7815776 YP_002845630.1 CDS RAF_ORF1087 NC_012633.1 1102326 1102655 R hypothetical protein complement(1102326..1102655) Rickettsia africae ESF-5 7815777 YP_002845631.1 CDS mreC NC_012633.1 1102910 1103749 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(1102910..1103749) Rickettsia africae ESF-5 7815778 YP_002845632.1 CDS mreB NC_012633.1 1103752 1104792 R functions in MreBCD complex in some organisms; rod shape-determining protein MreB complement(1103752..1104792) Rickettsia africae ESF-5 7815779 YP_002845633.1 CDS RAF_ORF1090 NC_012633.1 1105003 1106091 R Putative permease complement(1105003..1106091) Rickettsia africae ESF-5 7815780 YP_002845634.1 CDS pal NC_012633.1 1106519 1106986 R Peptidoglycan-associated lipoprotein precursor complement(1106519..1106986) Rickettsia africae ESF-5 7815782 YP_002845635.1 CDS RAF_ORF1092 NC_012633.1 1107202 1107444 D hypothetical protein 1107202..1107444 Rickettsia africae ESF-5 7815783 YP_002845636.1 CDS fabH NC_012633.1 1107459 1108415 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase complement(1107459..1108415) Rickettsia africae ESF-5 7815784 YP_002845637.1 CDS rpmF NC_012633.1 1108423 1108623 R some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 complement(1108423..1108623) Rickettsia africae ESF-5 7815785 YP_002845638.1 CDS smpA NC_012633.1 1108719 1109192 D tmRNA-binding protein 1108719..1109192 Rickettsia africae ESF-5 7815786 YP_002845639.1 CDS ftsY NC_012633.1 1109396 1110307 D Signal recognition particle-docking protein FtsY 1109396..1110307 Rickettsia africae ESF-5 7815787 YP_002845640.1 CDS polA NC_012633.1 1110473 1113100 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1110473..1113100 Rickettsia africae ESF-5 7815788 YP_002845641.1 CDS dnaE NC_012633.1 1115704 1119249 R catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha complement(1115704..1119249) Rickettsia africae ESF-5 7815791 YP_002845642.1 CDS udg NC_012633.1 1119366 1120664 R UDP-glucose 6-dehydrogenase complement(1119366..1120664) Rickettsia africae ESF-5 7815792 YP_002845643.1 CDS RAF_ORF1105 NC_012633.1 1120913 1123423 D hypothetical protein 1120913..1123423 Rickettsia africae ESF-5 7815793 YP_002845644.1 CDS ampG3 NC_012633.1 1123450 1125096 D AmpG protein 1123450..1125096 Rickettsia africae ESF-5 7815794 YP_002845645.1 CDS tatC NC_012633.1 1125163 1125918 D Sec-independent protein translocase protein TatC 1125163..1125918 Rickettsia africae ESF-5 7815795 YP_002845646.1 CDS serS NC_012633.1 1125896 1127173 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1125896..1127173 Rickettsia africae ESF-5 7815796 YP_002845647.1 CDS virB4-2 NC_012633.1 1127518 1129950 D VirB4 1127518..1129950 Rickettsia africae ESF-5 7815797 YP_002845648.1 CDS RAF_ORF1110 NC_012633.1 1130086 1133574 D hypothetical protein 1130086..1133574 Rickettsia africae ESF-5 7815798 YP_002845649.1 CDS terC NC_012633.1 1133579 1134484 D Tellurium resistance protein TerC 1133579..1134484 Rickettsia africae ESF-5 7815799 YP_002845650.1 CDS RAF_ORF1112 NC_012633.1 1134528 1135241 D hypothetical protein 1134528..1135241 Rickettsia africae ESF-5 7815800 YP_002845651.1 CDS RAF_ORF1113 NC_012633.1 1135327 1136991 D Putative methyltransferase 1135327..1136991 Rickettsia africae ESF-5 7815801 YP_002845652.1 CDS RAF_ORF1114 NC_012633.1 1136997 1137755 D Putative transcriptional regulator 1136997..1137755 Rickettsia africae ESF-5 7815802 YP_002845653.1 CDS nuoJ NC_012633.1 1137788 1138405 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 1137788..1138405 Rickettsia africae ESF-5 7815803 YP_002845654.1 CDS nuoK NC_012633.1 1138380 1138712 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 1138380..1138712 Rickettsia africae ESF-5 7815804 YP_002845655.1 CDS nuoL1 NC_012633.1 1138703 1140685 D Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 1138703..1140685 Rickettsia africae ESF-5 7815805 YP_002845656.1 CDS nuoM NC_012633.1 1140839 1142320 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 1140839..1142320 Rickettsia africae ESF-5 7815806 YP_002845657.1 CDS ccmA NC_012633.1 1142650 1143309 D ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 1142650..1143309 Rickettsia africae ESF-5 7815807 YP_002845658.1 CDS nuoI NC_012633.1 1143788 1144267 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(1143788..1144267) Rickettsia africae ESF-5 7815808 YP_002845659.1 CDS nuoH NC_012633.1 1144454 1145473 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(1144454..1145473) Rickettsia africae ESF-5 7815809 YP_002845660.1 CDS nuoG NC_012633.1 1145595 1147610 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(1145595..1147610) Rickettsia africae ESF-5 7815810 YP_002845661.1 CDS RAF_ORF1123 NC_012633.1 1147613 1147969 R hypothetical protein complement(1147613..1147969) Rickettsia africae ESF-5 7815811 YP_002845662.1 CDS acnA NC_012633.1 1148138 1150774 R Catalyzes the conversion of citrate to isocitrate; aconitate hydratase complement(1148138..1150774) Rickettsia africae ESF-5 7815812 YP_002845663.1 CDS atpC NC_012633.1 1150956 1151294 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(1150956..1151294) Rickettsia africae ESF-5 7815813 YP_002845664.1 CDS atpD NC_012633.1 1151352 1152773 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(1151352..1152773) Rickettsia africae ESF-5 7815814 YP_002845665.1 CDS atpG NC_012633.1 1152946 1153917 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(1152946..1153917) Rickettsia africae ESF-5 7815815 YP_002845666.1 CDS atpA NC_012633.1 1154050 1155651 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(1154050..1155651) Rickettsia africae ESF-5 7815816 YP_002845667.1 CDS atpH NC_012633.1 1155748 1156302 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(1155748..1156302) Rickettsia africae ESF-5 7815817 YP_002845668.1 CDS lpdA1 NC_012633.1 1156464 1157843 R Catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase complement(1156464..1157843) Rickettsia africae ESF-5 7815818 YP_002845669.1 CDS RAF_ORF1131 NC_012633.1 1157994 1158422 R Strees induced DNA-binding Dps family protein complement(1157994..1158422) Rickettsia africae ESF-5 7815819 YP_002845670.1 CDS mrcA NC_012633.1 1160714 1163086 R Penicillin-binding protein 1A complement(1160714..1163086) Rickettsia africae ESF-5 7815419 YP_002845671.1 CDS miaB NC_012633.1 1163090 1164427 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(1163090..1164427) Rickettsia africae ESF-5 7815420 YP_002845672.1 CDS RAF_ORF1140 NC_012633.1 1166090 1166443 R hypothetical protein complement(1166090..1166443) Rickettsia africae ESF-5 7815422 YP_002845673.1 CDS RAF_ORF1141 NC_012633.1 1166751 1167254 R hypothetical protein complement(1166751..1167254) Rickettsia africae ESF-5 7815423 YP_002845674.1 CDS kefB NC_012633.1 1167223 1168950 R Glutathione-regulated potassium-efflux system protein KefB complement(1167223..1168950) Rickettsia africae ESF-5 7815424 YP_002845675.1 CDS RAF_ORF1143 NC_012633.1 1168947 1169273 R Iojap-related protein complement(1168947..1169273) Rickettsia africae ESF-5 7815425 YP_002845676.1 CDS bolA2 NC_012633.1 1169429 1169668 D BolA-like protein 1169429..1169668 Rickettsia africae ESF-5 7815426 YP_002845677.1 CDS sca9 NC_012633.1 1175659 1176579 R Cell surface antigen Sca9 complement(1175659..1176579) Rickettsia africae ESF-5 7815428 YP_002845678.1 CDS infA NC_012633.1 1177352 1177567 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1177352..1177567 Rickettsia africae ESF-5 7815430 YP_002845679.1 CDS maf NC_012633.1 1177579 1178226 D Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1177579..1178226 Rickettsia africae ESF-5 7815431 YP_002845680.1 CDS dksA NC_012633.1 1178360 1178791 R DnaK suppressor-like protein complement(1178360..1178791) Rickettsia africae ESF-5 7815432 YP_002845681.1 CDS xerC NC_012633.1 1178959 1179876 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC complement(1178959..1179876) Rickettsia africae ESF-5 7815433 YP_002845682.1 CDS RAF_ORF1160 NC_012633.1 1180046 1180327 D Phasin family protein 1180046..1180327 Rickettsia africae ESF-5 7815434 YP_002845683.1 CDS pldA NC_012633.1 1180375 1180977 R phospholipase D complement(1180375..1180977) Rickettsia africae ESF-5 7815435 YP_002845684.1 CDS ubiD NC_012633.1 1181755 1183233 R UbiD family decarboxylase complement(1181755..1183233) Rickettsia africae ESF-5 7815437 YP_002845685.1 CDS surA NC_012633.1 1183387 1184961 R Parvulin-like peptidyl-prolyl isomerase complement(1183387..1184961) Rickettsia africae ESF-5 7815438 YP_002845686.1 CDS ompA NC_012633.1 1185155 1191436 R outer memberane protein OmpA complement(1185155..1191436) Rickettsia africae ESF-5 7815439 YP_002845687.1 CDS ftsK NC_012633.1 1192074 1194308 R cell division protein FtsK complement(1192074..1194308) Rickettsia africae ESF-5 7815440 YP_002845688.1 CDS RAF_ORF1168 NC_012633.1 1194477 1195346 R Putative acyltransferase complement(1194477..1195346) Rickettsia africae ESF-5 7815441 YP_002845689.1 CDS map NC_012633.1 1195502 1196281 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 1195502..1196281 Rickettsia africae ESF-5 7815442 YP_002845690.1 CDS mraY2 NC_012633.1 1197202 1198185 D UDP-phosphate alpha-N-acetylglucosaminyltransferase 1197202..1198185 Rickettsia africae ESF-5 7815444 YP_002845691.1 CDS RAF_ORF1173 NC_012633.1 1198182 1198505 D hypothetical protein 1198182..1198505 Rickettsia africae ESF-5 7815445 YP_002845692.1 CDS RAF_ORF1174 NC_012633.1 1198893 1199630 R hypothetical protein complement(1198893..1199630) Rickettsia africae ESF-5 7815446 YP_002845693.1 CDS RAF_ORF1175 NC_012633.1 1199877 1200560 R Putative outer surface protein complement(1199877..1200560) Rickettsia africae ESF-5 7815447 YP_002845694.1 CDS fdxA NC_012633.1 1200844 1201194 R Ferredoxin complement(1200844..1201194) Rickettsia africae ESF-5 7815448 YP_002845695.1 CDS ccmC NC_012633.1 1201199 1201891 R Heme exporter protein C complement(1201199..1201891) Rickettsia africae ESF-5 7815449 YP_002845696.1 CDS RAF_ORF1178 NC_012633.1 1201906 1202412 R cytosine deaminase complement(1201906..1202412) Rickettsia africae ESF-5 7815450 YP_002845697.1 CDS RAF_ORF1179 NC_012633.1 1202393 1203313 R Cation diffusion facilitator family transporter complement(1202393..1203313) Rickettsia africae ESF-5 7815451 YP_002845698.1 CDS omp NC_012633.1 1203480 1203959 D 17 kD surface antigen 1203480..1203959 Rickettsia africae ESF-5 7815452 YP_002845699.1 CDS RAF_ORF1181 NC_012633.1 1204090 1204554 D Phosphatidylethanolamine-binding protein PEBP 1204090..1204554 Rickettsia africae ESF-5 7815453 YP_002845700.1 CDS znuC NC_012633.1 1204694 1205395 D Zinc ABC transporter ATP-binding protein 1204694..1205395 Rickettsia africae ESF-5 7815454 YP_002845701.1 CDS RAF_ORF1185 NC_012633.1 1206660 1206956 R hypothetical protein complement(1206660..1206956) Rickettsia africae ESF-5 7815456 YP_002845702.1 CDS uvrA NC_012633.1 1207601 1210468 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(1207601..1210468) Rickettsia africae ESF-5 7815457 YP_002845703.1 CDS ssb NC_012633.1 1210571 1211029 D binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1210571..1211029 Rickettsia africae ESF-5 7815458 YP_002845704.1 CDS RAF_ORF1188 NC_012633.1 1211041 1211871 D DAP2 dipeptidyl aminopeptidase/acylaminoacyl-peptidase-like protein 1211041..1211871 Rickettsia africae ESF-5 7815459 YP_002845705.1 CDS RAF_ORF1189 NC_012633.1 1211912 1212205 D MFS-type sugar transporter 1211912..1212205 Rickettsia africae ESF-5 7815460 YP_002845706.1 CDS RAF_ORF1190 NC_012633.1 1212296 1212502 R lysozyme complement(1212296..1212502) Rickettsia africae ESF-5 7815461 YP_002845707.1 CDS RAF_ORF1191 NC_012633.1 1213541 1213858 D hypothetical protein 1213541..1213858 Rickettsia africae ESF-5 7815463 YP_002845708.1 CDS htpG NC_012633.1 1214002 1215867 D molecular chaperone; heat shock protein 90 1214002..1215867 Rickettsia africae ESF-5 7815464 YP_002845709.1 CDS hemA NC_012633.1 1216046 1217290 D catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine; 5-aminolevulinate synthase 1216046..1217290 Rickettsia africae ESF-5 7815465 YP_002845710.1 CDS tig NC_012633.1 1218945 1220282 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1218945..1220282 Rickettsia africae ESF-5 7815466 YP_002845711.1 CDS obgE NC_012633.1 1220386 1221432 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(1220386..1221432) Rickettsia africae ESF-5 7815467 YP_002845712.1 CDS gltA NC_012633.1 1221487 1222794 R type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase complement(1221487..1222794) Rickettsia africae ESF-5 7815468 YP_002845713.1 CDS RAF_ORF1197 NC_012633.1 1223495 1224334 R uracil-DNA glycosylase complement(1223495..1224334) Rickettsia africae ESF-5 7815469 YP_002845714.1 CDS RAF_ORF1198 NC_012633.1 1224297 1225238 D Ribosomal large subunit pseudouridine synthases RluD subfamily protein 1224297..1225238 Rickettsia africae ESF-5 7815470 YP_002845715.1 CDS hemK NC_012633.1 1226885 1228459 D fusion of hemK/trmB; N-terminal HemK domain transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; C-terminal; bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase 1226885..1228459 Rickettsia africae ESF-5 7815472 YP_002845716.1 CDS RAF_ORF1202 NC_012633.1 1228425 1229363 R Sua5/YciO/YrdC/YwlC family putative translation factor protein complement(1228425..1229363) Rickettsia africae ESF-5 7815473 YP_002845717.1 CDS glyS NC_012633.1 1229360 1231354 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(1229360..1231354) Rickettsia africae ESF-5 7815474 YP_002845718.1 CDS glyQ NC_012633.1 1231351 1232217 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(1231351..1232217) Rickettsia africae ESF-5 7815475 YP_002845719.1 CDS vapC3 NC_012633.1 1232249 1232656 R Toxin of toxin-antitoxin (TA) system VapC, containing PIN domain for nucleic acid binding complement(1232249..1232656) Rickettsia africae ESF-5 7815476 YP_002845720.1 CDS RAF_ORF1206 NC_012633.1 1232653 1232838 R Putative antitoxin of toxin-antitoxin (TA) system complement(1232653..1232838) Rickettsia africae ESF-5 7815477 YP_002845721.1 CDS RAF_ORF1207 NC_012633.1 1232986 1233615 R hypothetical protein complement(1232986..1233615) Rickettsia africae ESF-5 7815478 YP_002845722.1 CDS RAF_ORF1211 NC_012633.1 1235086 1236036 R hypothetical protein complement(1235086..1236036) Rickettsia africae ESF-5 7815480 YP_002845723.1 CDS RAF_ORF1212 NC_012633.1 1236046 1236681 R hypothetical protein complement(1236046..1236681) Rickettsia africae ESF-5 7815481 YP_002845724.1 CDS RAF_ORF1213 NC_012633.1 1236756 1238327 R hypothetical protein complement(1236756..1238327) Rickettsia africae ESF-5 7815482 YP_002845725.1 CDS alaS NC_012633.1 1238526 1241162 D Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1238526..1241162 Rickettsia africae ESF-5 7815483 YP_002845726.1 CDS truA NC_012633.1 1241371 1242108 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(1241371..1242108) Rickettsia africae ESF-5 7815484 YP_002845727.1 CDS rpoD NC_012633.1 1242204 1244108 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD complement(1242204..1244108) Rickettsia africae ESF-5 7815485 YP_002845728.1 CDS dnaG NC_012633.1 1244153 1245940 R synthesizes RNA primers at the replication forks; DNA primase complement(1244153..1245940) Rickettsia africae ESF-5 7815486 YP_002845729.1 CDS sec59 NC_012633.1 1245945 1246559 R dolichol kinase complement(1245945..1246559) Rickettsia africae ESF-5 7815487 YP_002845730.1 CDS greA NC_012633.1 1246758 1247315 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1246758..1247315 Rickettsia africae ESF-5 7815488 YP_002845731.1 CDS pntA2 NC_012633.1 1247474 1247872 R NAD(P) transhydrogenase subunit alpha complement(1247474..1247872) Rickettsia africae ESF-5 7815489 YP_002845732.1 CDS pntA1 NC_012633.1 1247869 1248993 R NAD(P) transhydrogenase subunit alpha complement(1247869..1248993) Rickettsia africae ESF-5 7815490 YP_002845733.1 CDS lolA NC_012633.1 1249069 1249707 D Outer membrane lipoprotein-sorting protein LolA 1249069..1249707 Rickettsia africae ESF-5 7815491 YP_002845734.1 CDS dnaX NC_012633.1 1249861 1251462 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; rhe tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 1249861..1251462 Rickettsia africae ESF-5 7815493 YP_002845735.1 CDS RAF_ORF1224 NC_012633.1 1251482 1251805 D hypothetical protein 1251482..1251805 Rickettsia africae ESF-5 7815494 YP_002845736.1 CDS RAF_ORF1225 NC_012633.1 1252670 1253365 R Putative aspartyl protease complement(1252670..1253365) Rickettsia africae ESF-5 7815495 YP_002845737.1 CDS RAF_ORF1226 NC_012633.1 1254553 1254792 R Antitoxin of toxin-antitoxin (TA) system StbD complement(1254553..1254792) Rickettsia africae ESF-5 7815496 YP_002845738.1 CDS glnQ NC_012633.1 1254998 1255720 R Glutamine ABC transporter ATP-binding protein complement(1254998..1255720) Rickettsia africae ESF-5 7815497 YP_002845739.1 CDS phnP NC_012633.1 1255724 1256488 R beta-lactamase complement(1255724..1256488) Rickettsia africae ESF-5 7815820 YP_002845740.1 CDS RAF_ORF1229 NC_012633.1 1256503 1257150 D hypothetical protein 1256503..1257150 Rickettsia africae ESF-5 7815821 YP_002845741.1 CDS dinJ NC_012633.1 1257244 1257507 D DNA-damage-inducible protein J 1257244..1257507 Rickettsia africae ESF-5 7815822 YP_002845742.1 CDS RAF_ORF1231 NC_012633.1 1257602 1257745 D hypothetical protein 1257602..1257745 Rickettsia africae ESF-5 7815823 YP_002845743.1 CDS RAF_ORF1232 NC_012633.1 1257854 1258963 D Putative permease 1257854..1258963 Rickettsia africae ESF-5 7815824 YP_002845744.1 CDS holC NC_012633.1 1258969 1259433 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(1258969..1259433) Rickettsia africae ESF-5 7815825 YP_002845745.1 CDS dapE NC_012633.1 1259633 1260778 R dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase complement(1259633..1260778) Rickettsia africae ESF-5 7815827 YP_002845746.1 CDS RAF_ORF1235 NC_012633.1 1260832 1261434 R Type I restriction/modification enzyme endonuclease S subunit complement(1260832..1261434) Rickettsia africae ESF-5 7815828 YP_002845747.1 CDS RAF_ORF1236 NC_012633.1 1261547 1261744 R hypothetical protein complement(1261547..1261744) Rickettsia africae ESF-5 7815829 YP_002845748.1 CDS RAF_ORF1240 NC_012633.1 1263221 1263451 R hypothetical protein complement(1263221..1263451) Rickettsia africae ESF-5 7815831 YP_002845749.1 CDS nhaA NC_012633.1 1263620 1264444 D Na+/H+ antiporter NhaA 1263620..1264444 Rickettsia africae ESF-5 7815832 YP_002845750.1 CDS RAF_ORF1242 NC_012633.1 1264533 1265048 R hypothetical protein complement(1264533..1265048) Rickettsia africae ESF-5 7815833 YP_002845751.1 CDS lipB NC_012633.1 1265045 1265674 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(1265045..1265674) Rickettsia africae ESF-5 7815834 YP_002845752.1 CDS ampD2 NC_012633.1 1265671 1266414 R Negative regulator of beta-lactamase expression complement(1265671..1266414) Rickettsia africae ESF-5 7815835 YP_002845753.1 CDS rpsP NC_012633.1 1266911 1267246 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(1266911..1267246) Rickettsia africae ESF-5 7815837 YP_002845754.1 CDS rpmG NC_012633.1 1267263 1267433 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(1267263..1267433) Rickettsia africae ESF-5 7815838 YP_002845755.1 CDS mutL NC_012633.1 1267655 1269487 R This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein complement(1267655..1269487) Rickettsia africae ESF-5 7815839 YP_002845756.1 CDS RAF_ORF1248 NC_012633.1 1269484 1269648 R hypothetical protein complement(1269484..1269648) Rickettsia africae ESF-5 7815840 YP_002845757.1 CDS proP7 NC_012633.1 1272546 1273820 D Proline/betaine transporter 1272546..1273820 Rickettsia africae ESF-5 7815843 YP_002845758.1 CDS hemF NC_012633.1 1273804 1274643 D catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 1273804..1274643 Rickettsia africae ESF-5 7815844 YP_002845759.1 CDS RAF_ORF1257 NC_012633.1 1275659 1276096 R hypothetical protein complement(1275659..1276096) Rickettsia africae ESF-5 7815846 YP_002845760.1 CDS hemH NC_012633.1 1276108 1277148 R protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase complement(1276108..1277148) Rickettsia africae ESF-5 7815847 YP_002845761.1 CDS hemE NC_012633.1 1277105 1278145 R catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase complement(1277105..1278145) Rickettsia africae ESF-5 7815848 YP_002845762.1 CDS RAF_pORF1260 NC_012634.1 1 2223 D Unknown (DnaA-like) 1..2223 Rickettsia africae ESF-5 7803247 YP_002845763.1 CDS RAF_pORF1261 NC_012634.1 2263 2964 D hypothetical protein 2263..2964 Rickettsia africae ESF-5 7803237 YP_002845764.1 CDS RAF_pORF1262 NC_012634.1 3122 3706 D Site-specific recombinase, DNA invertase Pin-like protein 3122..3706 Rickettsia africae ESF-5 7803238 YP_002845765.1 CDS RAF_pORF1263 NC_012634.1 3862 4503 R Transposase and inactivated derivative complement(3862..4503) Rickettsia africae ESF-5 7803239 YP_002845766.1 CDS RAF_pORF1264 NC_012634.1 4676 5761 R Transposase and inactivated derivative complement(4676..5761) Rickettsia africae ESF-5 7803240 YP_002845767.1 CDS RAF_pORF1265 NC_012634.1 5805 6203 R hypothetical protein complement(5805..6203) Rickettsia africae ESF-5 7803241 YP_002845768.1 CDS RAF_pORF1266 NC_012634.1 6236 6535 R hypothetical protein complement(6236..6535) Rickettsia africae ESF-5 7803242 YP_002845769.1 CDS RAF_pORF1267 NC_012634.1 7255 7626 R hypothetical protein complement(7255..7626) Rickettsia africae ESF-5 7803243 YP_002845770.1 CDS sca12 NC_012634.1 7776 10421 R Cell surface antigen Sca12 complement(7776..10421) Rickettsia africae ESF-5 7803244 YP_002845771.1 CDS RAF_pORF1269 NC_012634.1 10574 11047 D hypothetical protein 10574..11047 Rickettsia africae ESF-5 7803245 YP_002845772.1 CDS parA2 NC_012634.1 11231 11902 R Plasmid stability protein ParA complement(11231..11902) Rickettsia africae ESF-5 7803246 RAF_RNA01 tRNA RAF_RNA01 NC_012633.1 9595 9670 R tRNA-Phe complement(9595..9670) Rickettsia africae ESF-5 7815860 RAF_RNA02 tRNA RAF_RNA02 NC_012633.1 23024 23098 D tRNA-Glu 23024..23098 Rickettsia africae ESF-5 7815869 RAF_RNA03 tRNA RAF_RNA03 NC_012633.1 103809 103883 D tRNA-Thr 103809..103883 Rickettsia africae ESF-5 7815355 RAF_RNA04 tRNA RAF_RNA04 NC_012633.1 130479 130555 D tRNA-Met 130479..130555 Rickettsia africae ESF-5 7815377 RAF_RNA05 tRNA RAF_RNA05 NC_012633.1 175356 175431 D tRNA-Trp 175356..175431 Rickettsia africae ESF-5 7815413 RAF_RNA06 tRNA RAF_RNA06 NC_012633.1 210458 210533 R tRNA-Thr complement(210458..210533) Rickettsia africae ESF-5 7815201 RAF_RNA09 tRNA RAF_RNA09 NC_012633.1 322713 322789 D tRNA-Met 322713..322789 Rickettsia africae ESF-5 7815294 RAF_RNA10 tRNA RAF_RNA10 NC_012633.1 371141 371215 D tRNA-Asn 371141..371215 Rickettsia africae ESF-5 7815020 RAF_RNA11 tRNA RAF_RNA11 NC_012633.1 485051 485125 D tRNA-Cys 485051..485125 Rickettsia africae ESF-5 7815525 RAF_RNA12 tRNA RAF_RNA12 NC_012633.1 516259 516334 D tRNA-Lys 516259..516334 Rickettsia africae ESF-5 7815550 RAF_RNA13 tRNA RAF_RNA13 NC_012633.1 516349 516425 D tRNA-Ile 516349..516425 Rickettsia africae ESF-5 7815551 RAF_RNA14 tRNA RAF_RNA14 NC_012633.1 618854 618930 R tRNA-Asp complement(618854..618930) Rickettsia africae ESF-5 7815003 RAF_RNA16 tRNA RAF_RNA16 NC_012633.1 695083 695159 R tRNA-Val complement(695083..695159) Rickettsia africae ESF-5 7815151 RAF_RNA17 tRNA RAF_RNA17 NC_012633.1 699325 699400 D tRNA-Ala 699325..699400 Rickettsia africae ESF-5 7815156 RAF_RNA18 tRNA RAF_RNA18 NC_012633.1 713851 713925 D tRNA-Gln 713851..713925 Rickettsia africae ESF-5 7815173 RAF_RNA19 tRNA RAF_RNA19 NC_012633.1 714007 714083 R tRNA-Arg complement(714007..714083) Rickettsia africae ESF-5 7815174 RAF_RNA20 tRNA RAF_RNA20 NC_012633.1 728478 728567 D tRNA-Ser 728478..728567 Rickettsia africae ESF-5 7815673 RAF_RNA21 tRNA RAF_RNA21 NC_012633.1 750429 750516 D tRNA-Ser 750429..750516 Rickettsia africae ESF-5 7815695 RAF_RNA22 tRNA RAF_RNA22 NC_012633.1 789917 789993 D tRNA-Arg 789917..789993 Rickettsia africae ESF-5 7815729 RAF_RNA23 tRNA RAF_RNA23 NC_012633.1 830677 830751 R tRNA-Ala complement(830677..830751) Rickettsia africae ESF-5 7815599 RAF_RNA24 tRNA RAF_RNA24 NC_012633.1 842657 842743 D tRNA-Leu 842657..842743 Rickettsia africae ESF-5 7815609 RAF_RNA25 tRNA RAF_RNA25 NC_012633.1 847448 847522 D tRNA-Gly 847448..847522 Rickettsia africae ESF-5 7815615 RAF_RNA27 tRNA RAF_RNA27 NC_012633.1 930324 930399 R tRNA-Val complement(930324..930399) Rickettsia africae ESF-5 7814881 RAF_RNA28 tRNA RAF_RNA28 NC_012633.1 945789 945862 R tRNA-Gly complement(945789..945862) Rickettsia africae ESF-5 7814911 RAF_RNA29 tRNA RAF_RNA29 NC_012633.1 945998 946083 R tRNA-Tyr complement(945998..946083) Rickettsia africae ESF-5 7814912 RAF_RNA30 tRNA RAF_RNA30 NC_012633.1 957358 957443 D tRNA-Leu 957358..957443 Rickettsia africae ESF-5 7814926 RAF_RNA31 tRNA RAF_RNA31 NC_012633.1 1002547 1002623 D tRNA-His 1002547..1002623 Rickettsia africae ESF-5 7815957 RAF_RNA33 tRNA RAF_RNA33 NC_012633.1 1050532 1050623 D tRNA-Ser 1050532..1050623 Rickettsia africae ESF-5 7816000 RAF_RNA34 tRNA RAF_RNA34 NC_012633.1 1106133 1106209 R tRNA-Met complement(1106133..1106209) Rickettsia africae ESF-5 7815781 RAF_RNA35 tRNA RAF_RNA35 NC_012633.1 1177258 1177334 D tRNA-Pro 1177258..1177334 Rickettsia africae ESF-5 7815429 RAF_RNA36 tRNA RAF_RNA36 NC_012633.1 1213368 1213444 R tRNA-Arg complement(1213368..1213444) Rickettsia africae ESF-5 7815462 RAF_RNA38 tRNA RAF_RNA38 NC_012633.1 1259470 1259554 R tRNA-Leu complement(1259470..1259554) Rickettsia africae ESF-5 7815826 RAF_RNA39 tRNA RAF_RNA39 NC_012633.1 1266652 1266726 R tRNA-Thr complement(1266652..1266726) Rickettsia africae ESF-5 7815836 RAF_RNA07 rRNA rrl NC_012633.1 284170 286930 D 23S ribosomal RNA 284170..286930 Rickettsia africae ESF-5 7815260 RAF_RNA08 rRNA rrf NC_012633.1 287208 287326 D 5S ribosomal RNA 287208..287326 Rickettsia africae ESF-5 7815261 RAF_RNA26 rRNA rrs NC_012633.1 893136 894646 R 16S ribosomal RNA complement(893136..894646) Rickettsia africae ESF-5 7815656